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Search of human proteins with 51317384
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|51317384 GLE1 RNA export mediator homolog isoform 1 [Homo
sapiens]
(698 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|51317384 GLE1 RNA export mediator homolog isoform 1 [Homo sap... 1394 0.0
gi|4557627 GLE1 RNA export mediator homolog isoform 2 [Homo sapi... 1310 0.0
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 60 5e-09
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 59 2e-08
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 58 3e-08
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 58 3e-08
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 58 3e-08
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 58 3e-08
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa... 58 3e-08
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 58 3e-08
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 58 3e-08
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 57 4e-08
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 57 6e-08
gi|148746195 trichohyalin [Homo sapiens] 56 1e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 56 1e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 56 1e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 56 1e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 56 1e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 56 1e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 56 1e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 56 1e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 56 1e-07
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 55 2e-07
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 55 3e-07
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 54 4e-07
gi|221139761 zinc finger protein 853 [Homo sapiens] 54 5e-07
gi|154354985 hook homolog 2 isoform 1 [Homo sapiens] 53 8e-07
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 53 8e-07
gi|154354987 hook homolog 2 isoform 2 [Homo sapiens] 53 1e-06
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi... 53 1e-06
>gi|51317384 GLE1 RNA export mediator homolog isoform 1 [Homo
sapiens]
Length = 698
Score = 1394 bits (3609), Expect = 0.0
Identities = 698/698 (100%), Positives = 698/698 (100%)
Query: 1 MPSEGRCWETLKALRSSDKGRLCYYRDWLLRREDVLEECMSLPKLSSYSGWVVEHVLPHM 60
MPSEGRCWETLKALRSSDKGRLCYYRDWLLRREDVLEECMSLPKLSSYSGWVVEHVLPHM
Sbjct: 1 MPSEGRCWETLKALRSSDKGRLCYYRDWLLRREDVLEECMSLPKLSSYSGWVVEHVLPHM 60
Query: 61 QENQPLSETSPSSTSASALDQPSFVPKSPDASSAFSPASPATPNGTKGKDESQHTESMVL 120
QENQPLSETSPSSTSASALDQPSFVPKSPDASSAFSPASPATPNGTKGKDESQHTESMVL
Sbjct: 61 QENQPLSETSPSSTSASALDQPSFVPKSPDASSAFSPASPATPNGTKGKDESQHTESMVL 120
Query: 121 QSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQ 180
QSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQ
Sbjct: 121 QSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQ 180
Query: 181 HKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEE 240
HKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEE
Sbjct: 181 HKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEE 240
Query: 241 GQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSES 300
GQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSES
Sbjct: 241 GQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSES 300
Query: 301 SYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAH 360
SYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAH
Sbjct: 301 SYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAH 360
Query: 361 KEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKIKM 420
KEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKIKM
Sbjct: 361 KEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKIKM 420
Query: 421 DLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKL 480
DLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKL
Sbjct: 421 DLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKL 480
Query: 481 AEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGDLILAHLHKKCPYSVPFYPTFKE 540
AEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGDLILAHLHKKCPYSVPFYPTFKE
Sbjct: 481 AEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGDLILAHLHKKCPYSVPFYPTFKE 540
Query: 541 GMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQEIHPHGLNH 600
GMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQEIHPHGLNH
Sbjct: 541 GMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQEIHPHGLNH 600
Query: 601 GWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMLILIKEDYFPRIEAIT 660
GWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMLILIKEDYFPRIEAIT
Sbjct: 601 GWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMLILIKEDYFPRIEAIT 660
Query: 661 SSGQMGSFIRLKQFLEKCLQHKDIPVPKGFLTSSFWRS 698
SSGQMGSFIRLKQFLEKCLQHKDIPVPKGFLTSSFWRS
Sbjct: 661 SSGQMGSFIRLKQFLEKCLQHKDIPVPKGFLTSSFWRS 698
>gi|4557627 GLE1 RNA export mediator homolog isoform 2 [Homo
sapiens]
Length = 659
Score = 1310 bits (3390), Expect = 0.0
Identities = 656/658 (99%), Positives = 657/658 (99%)
Query: 1 MPSEGRCWETLKALRSSDKGRLCYYRDWLLRREDVLEECMSLPKLSSYSGWVVEHVLPHM 60
MPSEGRCWETLKALRSSDKGRLCYYRDWLLRREDVLEECMSLPKLSSYSGWVVEHVLPHM
Sbjct: 1 MPSEGRCWETLKALRSSDKGRLCYYRDWLLRREDVLEECMSLPKLSSYSGWVVEHVLPHM 60
Query: 61 QENQPLSETSPSSTSASALDQPSFVPKSPDASSAFSPASPATPNGTKGKDESQHTESMVL 120
QENQPLSETSPSSTSASALDQPSFVPKSPDASSAFSPASPATPNGTKGKDESQHTESMVL
Sbjct: 61 QENQPLSETSPSSTSASALDQPSFVPKSPDASSAFSPASPATPNGTKGKDESQHTESMVL 120
Query: 121 QSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQ 180
QSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQ
Sbjct: 121 QSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQ 180
Query: 181 HKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEE 240
HKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEE
Sbjct: 181 HKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEE 240
Query: 241 GQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSES 300
GQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSES
Sbjct: 241 GQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSES 300
Query: 301 SYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAH 360
SYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAH
Sbjct: 301 SYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAH 360
Query: 361 KEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKIKM 420
KEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKIKM
Sbjct: 361 KEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKIKM 420
Query: 421 DLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKL 480
DLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKL
Sbjct: 421 DLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKL 480
Query: 481 AEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGDLILAHLHKKCPYSVPFYPTFKE 540
AEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGDLILAHLHKKCPYSVPFYPTFKE
Sbjct: 481 AEKFVKQGEEEVASHHEAAFPIAVVASGIWELHPRVGDLILAHLHKKCPYSVPFYPTFKE 540
Query: 541 GMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQEIHPHGLNH 600
GMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQEIHPHGLNH
Sbjct: 541 GMALEDYQRMLGYQVKDSKVEQQDNFLKRMSGMIRLYAAIIQLRWPYGNRQEIHPHGLNH 600
Query: 601 GWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMLILIKEDYFPRIEA 658
GWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMLILIKEDYFPR +A
Sbjct: 601 GWRWLAQILNMEPLSDVTATLLFDFLEVCGNALMKQYQVQFWKMLILIKEDYFPRYQA 658
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 60.5 bits (145), Expect = 5e-09
Identities = 55/257 (21%), Positives = 121/257 (47%), Gaps = 39/257 (15%)
Query: 127 KVEGCVRMYELVHRMKGTEGLRLWQEEQ-----ERKVQALSEMASEQLKRFDEWKELKQH 181
K++ V EL +R+ + ++W++E+ E K+Q E EQ ++ +E+
Sbjct: 268 KLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWE 327
Query: 182 KEFQDLRE---VMEKSSR-----EALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQA-- 231
KE + R+ + EK + E + QEK++ + R + K+RE E+++ ++A
Sbjct: 328 KEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE--EEKIREQEKRQEQEAKM 385
Query: 232 --EQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSL 289
++E++R++E +IR QEEM+Q ++ ++ K + + Q
Sbjct: 386 WRQEEKIREQEEKIR------EQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEK------ 433
Query: 290 ISGIIRASSESSYPTAESQAEAERALREMRDLLM----NLGQEITRACEDKRRQDEEEAQ 345
+R E + E E +RE +++ +G++ + CE + + E+E +
Sbjct: 434 ----MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEK 489
Query: 346 VKLQEAQMQQGPEAHKE 362
++ QE ++++ + +E
Sbjct: 490 MRRQEEKIREQEKKIRE 506
Score = 55.1 bits (131), Expect = 2e-07
Identities = 48/229 (20%), Positives = 110/229 (48%), Gaps = 24/229 (10%)
Query: 133 RMYELVHRMKGTEGLRLWQE--EQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREV 190
++ EL +M E +R +E ++E K++ + ++ K + + +++++ +E +E
Sbjct: 345 KIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEE 404
Query: 191 MEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYA 250
M + E +G QE+ E + K+R E++ +Q ++++R++E +IR
Sbjct: 405 MMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQ--EKKIREQEEKIRE----- 457
Query: 251 LQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAE 310
QEEM+Q Q+ EQ + + + A Q + ++ R E + E
Sbjct: 458 -QEEMMQ-EQEEKMGEQEGKMCEQE-AKMQEQEEKM--------RRQEEKIREQEKKIRE 506
Query: 311 AERALREMRDLLMN----LGQEITRACEDKRRQDEEEAQVKLQEAQMQQ 355
E +RE +++ + ++ + CE + + E+E +++ QE +M++
Sbjct: 507 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMRE 555
Score = 46.6 bits (109), Expect = 8e-05
Identities = 55/265 (20%), Positives = 107/265 (40%), Gaps = 64/265 (24%)
Query: 110 DESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEE-----QERKVQALSEM 164
+E H + + + + E +R E + + ++W++E QE K++ EM
Sbjct: 350 EEKMHEQEKIREQEEKRQEEEKIREQE----KRQEQEAKMWRQEEKIREQEEKIREQEEM 405
Query: 165 ASEQLKRFDEWKEL--KQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLRE 222
EQ ++ E +E +Q +E Q+ E M + E + QEK E + + ++E
Sbjct: 406 MQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQE-EKIREQEKKIREQEEKIREQEEMMQE 464
Query: 223 ------------AEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKA 270
EQ+ Q ++E++R++E +IR ++E Q+ EQ +
Sbjct: 465 QEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIR-------EQEKKIREQEEKIREQEE- 516
Query: 271 LLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEIT 330
+++ E + E E E ++E +E
Sbjct: 517 ----------------------MMQEQEEKMWEQEEKMCEQEEKMQEQ--------EEKM 546
Query: 331 RACEDKRRQDEEEAQVKLQEAQMQQ 355
R E+K R E+E +++ QE +MQ+
Sbjct: 547 RRQEEKMR--EQEVRLRQQEEKMQE 569
Score = 45.8 bits (107), Expect = 1e-04
Identities = 65/326 (19%), Positives = 127/326 (38%), Gaps = 53/326 (16%)
Query: 87 KSPDASSAFSPASPATPNGTKGKDESQHTESMVLQSSRG---IKVEGCVRMYELVHRMKG 143
K DA S + T K K+ + +++S + + V+ R E +
Sbjct: 188 KERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP 247
Query: 144 TEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKE-------------------- 183
+ L+ + +++Q++S Q++ + W L Q +E
Sbjct: 248 QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQ 307
Query: 184 FQDLREVMEKSSR---------EALGHQEKLKAEHRHRAKILNLKLREAE---QQRVKQA 231
+ +RE EK R E + QE++ E + + L K+ E E +Q K+
Sbjct: 308 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 367
Query: 232 EQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLIS 291
E+E++R++E + A QEE ++ Q+ EQ + + + + + G Q
Sbjct: 368 EEEKIREQEKRQEQEAKMWRQEEKIR-EQEEKIREQEEMMQEQE----EKMGEQ------ 416
Query: 292 GIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEA 351
E + E E E +R + + ++I R E+K R+ EE Q + ++
Sbjct: 417 ------EEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI-REQEEKIREQEEMMQEQEEKM 469
Query: 352 QMQQGPEAHKEPPAPSQGPGGKQNED 377
Q+G +E Q ++ E+
Sbjct: 470 GEQEGKMCEQEAKMQEQEEKMRRQEE 495
Score = 40.8 bits (94), Expect = 0.004
Identities = 28/129 (21%), Positives = 60/129 (46%), Gaps = 21/129 (16%)
Query: 153 EQERKVQALSEMASEQLKRF--DEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
EQE K++ EM EQ ++ E K +Q + Q+ E M + + ++K++ +
Sbjct: 450 EQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEE 509
Query: 211 -----------HRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLS 259
K+ + + EQ+ Q ++E++R++E ++R E+ ++L
Sbjct: 510 KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMR--------EQEVRLR 561
Query: 260 QQLDASEQH 268
QQ + ++H
Sbjct: 562 QQEEKMQEH 570
Score = 29.6 bits (65), Expect = 9.9
Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 12/113 (10%)
Query: 109 KDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQE----EQERKVQALSEM 164
++E + + G E +M E +M+ E QE EQE K++ EM
Sbjct: 458 QEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 517
Query: 165 ASEQLKRFDEWKE--LKQHKEFQDLREVM---EKSSREA---LGHQEKLKAEH 209
EQ ++ E +E +Q ++ Q+ E M E+ RE L QE+ EH
Sbjct: 518 MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 58.9 bits (141), Expect = 2e-08
Identities = 73/328 (22%), Positives = 145/328 (44%), Gaps = 44/328 (13%)
Query: 58 PHMQENQPLSETSPSSTSASALDQPSFVPKSPDASSAFSPASPATPNGTKGKDESQHTES 117
P +E + L E S +S S Q P P A G++E++ E
Sbjct: 502 PEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEE 561
Query: 118 MVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKE 177
V S + ++ TE + ++ E ++A+ E ++ L++ + +
Sbjct: 562 KVAVSPTP----------PVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQ--DQRH 609
Query: 178 LKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLR 237
L + K+ + ++++ EK +E +E++ H+ + + L+ LRE Q+ +++ E+ R+R
Sbjct: 610 LLESKQ-EKMQQLREKLCQE---EEEEILRLHQQKEQSLS-SLRERLQKAIEE-EEARMR 663
Query: 238 KEEGQ----IRLRALYALQEEMLQLSQQLDAS-----EQHKALLKVDLAAFQTRGNQLCS 288
+EE Q +R + + Q + Q+ + +AS E+ ++ K + A+ + + Q+
Sbjct: 664 EEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLE 723
Query: 289 LISGIIRASSESSYPTAESQAEAERALREMRDLL------------MNLGQEITRAC--- 333
+ I AS +S A A E+AL+++R+ L E+ R C
Sbjct: 724 QLKEEIEASEKSE--QAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSL 781
Query: 334 EDKRRQDEEEAQVKLQEAQMQQGPEAHK 361
E K R+ Q K+QEAQ ++ + K
Sbjct: 782 EAKHREVVSSLQKKIQEAQQKEEAQLQK 809
Score = 44.3 bits (103), Expect = 4e-04
Identities = 55/229 (24%), Positives = 98/229 (42%), Gaps = 21/229 (9%)
Query: 145 EGLRLWQEEQER------KVQALSEMASEQLKRFDEWKELKQHKEFQDLREV----MEKS 194
E R+ +EE +R +VQ+ ++ +Q++ E K +E + ++ +E+
Sbjct: 658 EEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQK 717
Query: 195 SREALGH-QEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQE 253
+R+ L +E+++A + LN +A QQ +Q E ER +E L ++ +
Sbjct: 718 NRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGER---KEAVATLEKEHSAEL 774
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
E L S + E +L K A Q QL + + + SY A + E
Sbjct: 775 ERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSS 834
Query: 314 ALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKE 362
LRE R QE+ E + + +EE Q + +A+ Q E K+
Sbjct: 835 LLREKR-------QEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQ 876
Score = 40.8 bits (94), Expect = 0.004
Identities = 73/255 (28%), Positives = 113/255 (44%), Gaps = 38/255 (14%)
Query: 111 ESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLK 170
E+Q E LQ G +VE R+++ + + G E E + E+ E +
Sbjct: 798 EAQQKEEAQLQKCLG-QVEH--RVHQKSYHVAGYE-----HELSSLLREKRQEVEGEHER 849
Query: 171 RFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR-HRAKILNLKLREAEQ-QRV 228
R D+ KE Q +VM K+ +E+ +AE R RA++L E E+ QR
Sbjct: 850 RLDKMKEEHQ--------QVMAKA-------REQYEAEERKQRAELLGHLTGELERLQRA 894
Query: 229 KQAEQERLRKEEGQIR--LRALYALQEEMLQLSQQLDASEQHK------ALLKVDLAAFQ 280
+ E E +R+E+ + LR + QE LQ +LD + K ALL+V +
Sbjct: 895 HERELETVRQEQHKRLEDLRRRHREQERKLQ-DLELDLETRAKDVKARLALLEVQEETAR 953
Query: 281 TRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQD 340
QL + + S E+ TA Q + E A +E LL + Q E + R+
Sbjct: 954 REKQQLLDVQRQVALKSEEA---TATHQ-QLEEAQKEHTHLLQSNQQLREILDELQARKL 1009
Query: 341 EEEAQVKLQEAQMQQ 355
+ E+QV L +AQ QQ
Sbjct: 1010 KLESQVDLLQAQSQQ 1024
Score = 37.0 bits (84), Expect = 0.062
Identities = 49/203 (24%), Positives = 80/203 (39%), Gaps = 23/203 (11%)
Query: 142 KGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGH 201
K E LR EQERK+Q L D K K L EV E+++R
Sbjct: 908 KRLEDLRRRHREQERKLQDL---------ELDLETRAKDVKARLALLEVQEETAR----- 953
Query: 202 QEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLR-ALYALQEEMLQLSQ 260
+EK + R L + A Q++++A++E + +LR L LQ L+L
Sbjct: 954 REKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLES 1013
Query: 261 QLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRD 320
Q+D + L+ ++ + + L+ + + +S P E E D
Sbjct: 1014 QVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNAS-PHFEPDLHIE-------D 1065
Query: 321 LLMNLGQEITRACEDKRRQDEEE 343
L +LG T+ Q +E+
Sbjct: 1066 LRKSLGTNQTKEVSSSLSQSKED 1088
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 58.2 bits (139), Expect = 3e-08
Identities = 52/210 (24%), Positives = 102/210 (48%), Gaps = 18/210 (8%)
Query: 136 ELVHRMKGTE-GLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKS 194
E + R + E LR +EE+ER+ Q E L+R +E + ++ + Q+ E++ K
Sbjct: 786 EALRRQREQEIALRRQREEEERQQQ------EEALRRLEERRREEEERRKQE--ELLRKQ 837
Query: 195 SREALGH-QEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQE 253
EA +E+ +A+ R L + E E R++ E+ER RKE R + L ++
Sbjct: 838 EEEAAKWAREEEEAQRRLEENRLRM---EEEAARLRHEEEERKRKELEVQRQKELMRQRQ 894
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
+ + ++L +Q + L ++ L + T G Q S S+++ AE Q E
Sbjct: 895 QQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQ-----SNTTACQSQATLSLAEIQKLEEE 949
Query: 314 ALREMRDLLMNLGQEITRACEDKRRQDEEE 343
R++R+ +E+ +A + +++Q +++
Sbjct: 950 RERQLREEQRRQQRELMKALQQQQQQQQQK 979
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/239 (23%), Positives = 107/239 (44%), Gaps = 17/239 (7%)
Query: 165 ASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAE 224
A EQL++ ++ K K +E ++ E+ K E QE+L+ R + +IL R+ E
Sbjct: 716 ALEQLQQLEKAKAAKLEQERRE-AEMRAKREEEERKRQEELR---RQQEEILR---RQQE 768
Query: 225 QQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGN 284
++R ++ E+E R+++ + AL +E+ + L +Q + E+ + + + R
Sbjct: 769 EERKRREEEELARRKQEE----ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE 824
Query: 285 QLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEA 344
+ ++R E + A + EA+R L E R + + E+++R++ E
Sbjct: 825 EERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQ 884
Query: 345 QVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLT 403
+ K Q QQ EA + Q Q + Q+K+ + W QQ + Q T
Sbjct: 885 RQKELMRQRQQQQEALRRLQQQQQ-----QQQLAQMKLPS-SSTWGQQSNTTACQSQAT 937
Score = 48.5 bits (114), Expect = 2e-05
Identities = 54/234 (23%), Positives = 110/234 (47%), Gaps = 27/234 (11%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
E + +++ + +L QE +E +++A E E+ KR +E + ++ + E ++
Sbjct: 718 EQLQQLEKAKAAKLEQERREAEMRAKRE--EEERKRQEELRRQQEEILRRQQEEERKRRE 775
Query: 196 REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEM 255
E L +++ +A R R + + L+ + E++R Q ++E LR+ E + R QEE+
Sbjct: 776 EEELARRKQEEALRRQREQEIALRRQREEEER--QQQEEALRRLEERRREEEERRKQEEL 833
Query: 256 LQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERAL 315
L+ ++ E K + + A + N+L R E+ ++ E
Sbjct: 834 LRKQEE----EAAKWAREEEEAQRRLEENRL--------RMEEEA------ARLRHEEEE 875
Query: 316 REMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQG 369
R+ ++L + +E+ R +RQ ++EA +LQ+ Q QQ K P + + G
Sbjct: 876 RKRKELEVQRQKELMR-----QRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 924
Score = 40.4 bits (93), Expect = 0.006
Identities = 33/123 (26%), Positives = 60/123 (48%), Gaps = 12/123 (9%)
Query: 145 EGLRLWQEEQERK-----VQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREAL 199
E RL EE+ERK VQ E+ ++ ++ + + L+Q ++ Q L + M+ S
Sbjct: 865 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ-MKLPSSSTW 923
Query: 200 GHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLS 259
G Q A L AE Q++++ + +LR+E+ + + + ALQ++ Q
Sbjct: 924 GQQSNTTACQSQATLSL------AEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQ 977
Query: 260 QQL 262
Q+L
Sbjct: 978 QKL 980
Score = 30.0 bits (66), Expect = 7.6
Identities = 35/156 (22%), Positives = 66/156 (42%), Gaps = 5/156 (3%)
Query: 266 EQHKALLKV--DLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLM 323
E+ + LLK+ + Q Q C + + ++ PT S + + E+ D +
Sbjct: 1110 EEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIR 1169
Query: 324 NLGQEITRACEDKRRQDEEEAQVKL-QEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKV 382
+ + A E ++ E A+ K Q+ Q QQ P+ ++ P P Q P Q +D +
Sbjct: 1170 AYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQP-PQQPPQQPQQQDSVWGM 1228
Query: 383 QDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKI 418
T+ Q ++ Q FE + + K + +K+
Sbjct: 1229 NHSTLHSVFQTNQSNNQ-QSNFEAVQSGKKKKKQKM 1263
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 58.2 bits (139), Expect = 3e-08
Identities = 52/210 (24%), Positives = 102/210 (48%), Gaps = 18/210 (8%)
Query: 136 ELVHRMKGTE-GLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKS 194
E + R + E LR +EE+ER+ Q E L+R +E + ++ + Q+ E++ K
Sbjct: 813 EALRRQREQEIALRRQREEEERQQQ------EEALRRLEERRREEEERRKQE--ELLRKQ 864
Query: 195 SREALGH-QEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQE 253
EA +E+ +A+ R L + E E R++ E+ER RKE R + L ++
Sbjct: 865 EEEAAKWAREEEEAQRRLEENRLRM---EEEAARLRHEEEERKRKELEVQRQKELMRQRQ 921
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
+ + ++L +Q + L ++ L + T G Q S S+++ AE Q E
Sbjct: 922 QQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQ-----SNTTACQSQATLSLAEIQKLEEE 976
Query: 314 ALREMRDLLMNLGQEITRACEDKRRQDEEE 343
R++R+ +E+ +A + +++Q +++
Sbjct: 977 RERQLREEQRRQQRELMKALQQQQQQQQQK 1006
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/239 (23%), Positives = 107/239 (44%), Gaps = 17/239 (7%)
Query: 165 ASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAE 224
A EQL++ ++ K K +E ++ E+ K E QE+L+ R + +IL R+ E
Sbjct: 743 ALEQLQQLEKAKAAKLEQERRE-AEMRAKREEEERKRQEELR---RQQEEILR---RQQE 795
Query: 225 QQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGN 284
++R ++ E+E R+++ + AL +E+ + L +Q + E+ + + + R
Sbjct: 796 EERKRREEEELARRKQEE----ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE 851
Query: 285 QLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEA 344
+ ++R E + A + EA+R L E R + + E+++R++ E
Sbjct: 852 EERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQ 911
Query: 345 QVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLT 403
+ K Q QQ EA + Q Q + Q+K+ + W QQ + Q T
Sbjct: 912 RQKELMRQRQQQQEALRRLQQQQQ-----QQQLAQMKLPS-SSTWGQQSNTTACQSQAT 964
Score = 48.5 bits (114), Expect = 2e-05
Identities = 54/234 (23%), Positives = 110/234 (47%), Gaps = 27/234 (11%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
E + +++ + +L QE +E +++A E E+ KR +E + ++ + E ++
Sbjct: 745 EQLQQLEKAKAAKLEQERREAEMRAKRE--EEERKRQEELRRQQEEILRRQQEEERKRRE 802
Query: 196 REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEM 255
E L +++ +A R R + + L+ + E++R Q ++E LR+ E + R QEE+
Sbjct: 803 EEELARRKQEEALRRQREQEIALRRQREEEER--QQQEEALRRLEERRREEEERRKQEEL 860
Query: 256 LQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERAL 315
L+ ++ E K + + A + N+L R E+ ++ E
Sbjct: 861 LRKQEE----EAAKWAREEEEAQRRLEENRL--------RMEEEA------ARLRHEEEE 902
Query: 316 REMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQG 369
R+ ++L + +E+ R +RQ ++EA +LQ+ Q QQ K P + + G
Sbjct: 903 RKRKELEVQRQKELMR-----QRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 951
Score = 40.4 bits (93), Expect = 0.006
Identities = 33/123 (26%), Positives = 60/123 (48%), Gaps = 12/123 (9%)
Query: 145 EGLRLWQEEQERK-----VQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREAL 199
E RL EE+ERK VQ E+ ++ ++ + + L+Q ++ Q L + M+ S
Sbjct: 892 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ-MKLPSSSTW 950
Query: 200 GHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLS 259
G Q A L AE Q++++ + +LR+E+ + + + ALQ++ Q
Sbjct: 951 GQQSNTTACQSQATLSL------AEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQ 1004
Query: 260 QQL 262
Q+L
Sbjct: 1005 QKL 1007
Score = 30.0 bits (66), Expect = 7.6
Identities = 35/156 (22%), Positives = 66/156 (42%), Gaps = 5/156 (3%)
Query: 266 EQHKALLKV--DLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLM 323
E+ + LLK+ + Q Q C + + ++ PT S + + E+ D +
Sbjct: 1137 EEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIR 1196
Query: 324 NLGQEITRACEDKRRQDEEEAQVKL-QEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKV 382
+ + A E ++ E A+ K Q+ Q QQ P+ ++ P P Q P Q +D +
Sbjct: 1197 AYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQP-PQQPPQQPQQQDSVWGM 1255
Query: 383 QDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKI 418
T+ Q ++ Q FE + + K + +K+
Sbjct: 1256 NHSTLHSVFQTNQSNNQ-QSNFEAVQSGKKKKKQKM 1290
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 58.2 bits (139), Expect = 3e-08
Identities = 52/210 (24%), Positives = 102/210 (48%), Gaps = 18/210 (8%)
Query: 136 ELVHRMKGTE-GLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKS 194
E + R + E LR +EE+ER+ Q E L+R +E + ++ + Q+ E++ K
Sbjct: 792 EALRRQREQEIALRRQREEEERQQQ------EEALRRLEERRREEEERRKQE--ELLRKQ 843
Query: 195 SREALGH-QEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQE 253
EA +E+ +A+ R L + E E R++ E+ER RKE R + L ++
Sbjct: 844 EEEAAKWAREEEEAQRRLEENRLRM---EEEAARLRHEEEERKRKELEVQRQKELMRQRQ 900
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
+ + ++L +Q + L ++ L + T G Q S S+++ AE Q E
Sbjct: 901 QQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQ-----SNTTACQSQATLSLAEIQKLEEE 955
Query: 314 ALREMRDLLMNLGQEITRACEDKRRQDEEE 343
R++R+ +E+ +A + +++Q +++
Sbjct: 956 RERQLREEQRRQQRELMKALQQQQQQQQQK 985
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/239 (23%), Positives = 107/239 (44%), Gaps = 17/239 (7%)
Query: 165 ASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAE 224
A EQL++ ++ K K +E ++ E+ K E QE+L+ R + +IL R+ E
Sbjct: 722 ALEQLQQLEKAKAAKLEQERRE-AEMRAKREEEERKRQEELR---RQQEEILR---RQQE 774
Query: 225 QQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGN 284
++R ++ E+E R+++ + AL +E+ + L +Q + E+ + + + R
Sbjct: 775 EERKRREEEELARRKQEE----ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE 830
Query: 285 QLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEA 344
+ ++R E + A + EA+R L E R + + E+++R++ E
Sbjct: 831 EERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQ 890
Query: 345 QVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLT 403
+ K Q QQ EA + Q Q + Q+K+ + W QQ + Q T
Sbjct: 891 RQKELMRQRQQQQEALRRLQQQQQ-----QQQLAQMKLPS-SSTWGQQSNTTACQSQAT 943
Score = 48.5 bits (114), Expect = 2e-05
Identities = 54/234 (23%), Positives = 110/234 (47%), Gaps = 27/234 (11%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
E + +++ + +L QE +E +++A E E+ KR +E + ++ + E ++
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKRE--EEERKRQEELRRQQEEILRRQQEEERKRRE 781
Query: 196 REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEM 255
E L +++ +A R R + + L+ + E++R Q ++E LR+ E + R QEE+
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEER--QQQEEALRRLEERRREEEERRKQEEL 839
Query: 256 LQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERAL 315
L+ ++ E K + + A + N+L R E+ ++ E
Sbjct: 840 LRKQEE----EAAKWAREEEEAQRRLEENRL--------RMEEEA------ARLRHEEEE 881
Query: 316 REMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQG 369
R+ ++L + +E+ R +RQ ++EA +LQ+ Q QQ K P + + G
Sbjct: 882 RKRKELEVQRQKELMR-----QRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930
Score = 40.4 bits (93), Expect = 0.006
Identities = 33/123 (26%), Positives = 60/123 (48%), Gaps = 12/123 (9%)
Query: 145 EGLRLWQEEQERK-----VQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREAL 199
E RL EE+ERK VQ E+ ++ ++ + + L+Q ++ Q L + M+ S
Sbjct: 871 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ-MKLPSSSTW 929
Query: 200 GHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLS 259
G Q A L AE Q++++ + +LR+E+ + + + ALQ++ Q
Sbjct: 930 GQQSNTTACQSQATLSL------AEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQ 983
Query: 260 QQL 262
Q+L
Sbjct: 984 QKL 986
Score = 30.0 bits (66), Expect = 7.6
Identities = 35/156 (22%), Positives = 66/156 (42%), Gaps = 5/156 (3%)
Query: 266 EQHKALLKV--DLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLM 323
E+ + LLK+ + Q Q C + + ++ PT S + + E+ D +
Sbjct: 1116 EEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIR 1175
Query: 324 NLGQEITRACEDKRRQDEEEAQVKL-QEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKV 382
+ + A E ++ E A+ K Q+ Q QQ P+ ++ P P Q P Q +D +
Sbjct: 1176 AYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQP-PQQPPQQPQQQDSVWGM 1234
Query: 383 QDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKI 418
T+ Q ++ Q FE + + K + +K+
Sbjct: 1235 NHSTLHSVFQTNQSNNQ-QSNFEAVQSGKKKKKQKM 1269
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 58.2 bits (139), Expect = 3e-08
Identities = 52/210 (24%), Positives = 102/210 (48%), Gaps = 18/210 (8%)
Query: 136 ELVHRMKGTE-GLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKS 194
E + R + E LR +EE+ER+ Q E L+R +E + ++ + Q+ E++ K
Sbjct: 792 EALRRQREQEIALRRQREEEERQQQ------EEALRRLEERRREEEERRKQE--ELLRKQ 843
Query: 195 SREALGH-QEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQE 253
EA +E+ +A+ R L + E E R++ E+ER RKE R + L ++
Sbjct: 844 EEEAAKWAREEEEAQRRLEENRLRM---EEEAARLRHEEEERKRKELEVQRQKELMRQRQ 900
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
+ + ++L +Q + L ++ L + T G Q S S+++ AE Q E
Sbjct: 901 QQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQ-----SNTTACQSQATLSLAEIQKLEEE 955
Query: 314 ALREMRDLLMNLGQEITRACEDKRRQDEEE 343
R++R+ +E+ +A + +++Q +++
Sbjct: 956 RERQLREEQRRQQRELMKALQQQQQQQQQK 985
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/239 (23%), Positives = 107/239 (44%), Gaps = 17/239 (7%)
Query: 165 ASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAE 224
A EQL++ ++ K K +E ++ E+ K E QE+L+ R + +IL R+ E
Sbjct: 722 ALEQLQQLEKAKAAKLEQERRE-AEMRAKREEEERKRQEELR---RQQEEILR---RQQE 774
Query: 225 QQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGN 284
++R ++ E+E R+++ + AL +E+ + L +Q + E+ + + + R
Sbjct: 775 EERKRREEEELARRKQEE----ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE 830
Query: 285 QLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEA 344
+ ++R E + A + EA+R L E R + + E+++R++ E
Sbjct: 831 EERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQ 890
Query: 345 QVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLT 403
+ K Q QQ EA + Q Q + Q+K+ + W QQ + Q T
Sbjct: 891 RQKELMRQRQQQQEALRRLQQQQQ-----QQQLAQMKLPS-SSTWGQQSNTTACQSQAT 943
Score = 48.5 bits (114), Expect = 2e-05
Identities = 54/234 (23%), Positives = 110/234 (47%), Gaps = 27/234 (11%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
E + +++ + +L QE +E +++A E E+ KR +E + ++ + E ++
Sbjct: 724 EQLQQLEKAKAAKLEQERREAEMRAKRE--EEERKRQEELRRQQEEILRRQQEEERKRRE 781
Query: 196 REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEM 255
E L +++ +A R R + + L+ + E++R Q ++E LR+ E + R QEE+
Sbjct: 782 EEELARRKQEEALRRQREQEIALRRQREEEER--QQQEEALRRLEERRREEEERRKQEEL 839
Query: 256 LQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERAL 315
L+ ++ E K + + A + N+L R E+ ++ E
Sbjct: 840 LRKQEE----EAAKWAREEEEAQRRLEENRL--------RMEEEA------ARLRHEEEE 881
Query: 316 REMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQG 369
R+ ++L + +E+ R +RQ ++EA +LQ+ Q QQ K P + + G
Sbjct: 882 RKRKELEVQRQKELMR-----QRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930
Score = 40.4 bits (93), Expect = 0.006
Identities = 33/123 (26%), Positives = 60/123 (48%), Gaps = 12/123 (9%)
Query: 145 EGLRLWQEEQERK-----VQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREAL 199
E RL EE+ERK VQ E+ ++ ++ + + L+Q ++ Q L + M+ S
Sbjct: 871 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQ-MKLPSSSTW 929
Query: 200 GHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLS 259
G Q A L AE Q++++ + +LR+E+ + + + ALQ++ Q
Sbjct: 930 GQQSNTTACQSQATLSL------AEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQ 983
Query: 260 QQL 262
Q+L
Sbjct: 984 QKL 986
Score = 30.0 bits (66), Expect = 7.6
Identities = 35/156 (22%), Positives = 66/156 (42%), Gaps = 5/156 (3%)
Query: 266 EQHKALLKV--DLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLM 323
E+ + LLK+ + Q Q C + + ++ PT S + + E+ D +
Sbjct: 1116 EEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIR 1175
Query: 324 NLGQEITRACEDKRRQDEEEAQVKL-QEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKV 382
+ + A E ++ E A+ K Q+ Q QQ P+ ++ P P Q P Q +D +
Sbjct: 1176 AYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQP-PQQPPQQPQQQDSVWGM 1234
Query: 383 QDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKI 418
T+ Q ++ Q FE + + K + +K+
Sbjct: 1235 NHSTLHSVFQTNQSNNQ-QSNFEAVQSGKKKKKQKM 1269
>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
sapiens]
Length = 631
Score = 58.2 bits (139), Expect = 3e-08
Identities = 73/302 (24%), Positives = 125/302 (41%), Gaps = 32/302 (10%)
Query: 67 SETSPSSTSASALDQPSFVPKSPDASSAFSPASPATPNGT---KGKDESQHTE-SMVLQS 122
SE LD V PD T N T D Q E + +Q
Sbjct: 250 SEECKEKRGIIPLDAHCCVEVLPDRDGKRCMFCVKTANRTYEMSASDTRQRQEWTAAIQM 309
Query: 123 SRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHK 182
+ ++ EG ++ K + R Q EQ + +A E E+L R + +E K+ K
Sbjct: 310 AIRLQAEGKTSLH------KDLKQKRREQREQRERRRAAKE---EELLRLQQLQEEKERK 360
Query: 183 --EFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEE 240
E + L+E ++ R +E+ +++HR + L +LREAEQ R + L++EE
Sbjct: 361 LQELELLQEAQRQAERLLQEEEERRRSQHRELQQALEGQLREAEQARASMQAEMELKEEE 420
Query: 241 G---QIRLRALYALQ---EEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGII 294
+ R++ L +Q +E LQL + E+ + + L + + ++
Sbjct: 421 AARQRQRIKELEEMQQRLQEALQLEVKARRDEESVRIAQTRLLEEEE------EKLKQLM 474
Query: 295 RASSESSYPTAESQAEAERALREMRD---LLMNLGQEITRACEDKRRQDE--EEAQVKLQ 349
+ E +Q E E +EM L Q++ ++++R DE E AQ KL+
Sbjct: 475 QLKEEQERYIERAQQEKEELQQEMAQQSRSLQQAQQQLEEVRQNRQRADEDVEAAQRKLR 534
Query: 350 EA 351
+A
Sbjct: 535 QA 536
Score = 34.7 bits (78), Expect = 0.31
Identities = 39/163 (23%), Positives = 77/163 (47%), Gaps = 36/163 (22%)
Query: 222 EAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQT 281
+AE + + ++ R+E+ + R R A +EE+L+L Q + E+ + L +++L
Sbjct: 314 QAEGKTSLHKDLKQKRREQREQRERRRAAKEEELLRLQQLQE--EKERKLQELELLQ--- 368
Query: 282 RGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDE 341
E+Q +AER L+E + + +E+ +A E + R +
Sbjct: 369 ------------------------EAQRQAERLLQEEEERRRSQHRELQQALEGQLR-EA 403
Query: 342 EEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQD 384
E+A+ +Q A+M+ KE A Q K+ E++Q ++Q+
Sbjct: 404 EQARASMQ-AEMEL-----KEEEAARQRQRIKELEEMQQRLQE 440
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 58.2 bits (139), Expect = 3e-08
Identities = 57/228 (25%), Positives = 108/228 (47%), Gaps = 25/228 (10%)
Query: 145 EGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQE- 203
E ++L +EE+ RKV A E++++ E K+ + ++F + E EK+ E L ++
Sbjct: 568 EEVKLKREERLRKVL----QARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKA 623
Query: 204 KLKAEHRHRAKILNLKLREAEQQRVKQAEQE----------RLRKEEGQIRLRALYALQE 253
K KA + ++ + +E E +R++ +QE + +KEE Q RLR +
Sbjct: 624 KKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKR 683
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
Q Q+ E+ + + Q R Q R +E + + +AER
Sbjct: 684 LAEQREQERREQERREQERREQERREQERREQE--------RQLAEQERRREQERLQAER 735
Query: 314 ALREMRDLLMNLGQEITRACEDKRRQDEEE--AQVKLQEAQMQQGPEA 359
L+E L +++ R E+K++++E++ A+ +LQE Q ++ EA
Sbjct: 736 ELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 783
Score = 43.9 bits (102), Expect = 5e-04
Identities = 44/174 (25%), Positives = 79/174 (45%), Gaps = 14/174 (8%)
Query: 110 DESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLR----LWQEEQER-KVQALSEM 164
++++ + L + K +M E+ R K E R L QEE+ER + L +
Sbjct: 608 EKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKK 667
Query: 165 ASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAE 224
E+ +R + E K+ E ++ ++ + QE+ + E R + + L + R E
Sbjct: 668 KEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE 727
Query: 225 QQRVKQAEQE--------RLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKA 270
Q+R+ QAE+E RL+KE+ Q L +E+ +QL ++ KA
Sbjct: 728 QERL-QAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 58.2 bits (139), Expect = 3e-08
Identities = 57/228 (25%), Positives = 108/228 (47%), Gaps = 25/228 (10%)
Query: 145 EGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQE- 203
E ++L +EE+ RKV A E++++ E K+ + ++F + E EK+ E L ++
Sbjct: 564 EEVKLKREERLRKVL----QARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKA 619
Query: 204 KLKAEHRHRAKILNLKLREAEQQRVKQAEQE----------RLRKEEGQIRLRALYALQE 253
K KA + ++ + +E E +R++ +QE + +KEE Q RLR +
Sbjct: 620 KKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKR 679
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
Q Q+ E+ + + Q R Q R +E + + +AER
Sbjct: 680 LAEQREQERREQERREQERREQERREQERREQE--------RQLAEQERRREQERLQAER 731
Query: 314 ALREMRDLLMNLGQEITRACEDKRRQDEEE--AQVKLQEAQMQQGPEA 359
L+E L +++ R E+K++++E++ A+ +LQE Q ++ EA
Sbjct: 732 ELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEA 779
Score = 43.9 bits (102), Expect = 5e-04
Identities = 44/174 (25%), Positives = 79/174 (45%), Gaps = 14/174 (8%)
Query: 110 DESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLR----LWQEEQER-KVQALSEM 164
++++ + L + K +M E+ R K E R L QEE+ER + L +
Sbjct: 604 EKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKK 663
Query: 165 ASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAE 224
E+ +R + E K+ E ++ ++ + QE+ + E R + + L + R E
Sbjct: 664 KEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRRE 723
Query: 225 QQRVKQAEQE--------RLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKA 270
Q+R+ QAE+E RL+KE+ Q L +E+ +QL ++ KA
Sbjct: 724 QERL-QAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 776
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 57.4 bits (137), Expect = 4e-08
Identities = 75/307 (24%), Positives = 134/307 (43%), Gaps = 42/307 (13%)
Query: 147 LRLWQEEQERKVQALSEMASEQL------------KRFDEWKELKQHKEFQDLREVMEKS 194
L+ WQE+ +K QALS + E K + + +Q + RE +E+S
Sbjct: 1329 LKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQS 1388
Query: 195 SREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEE 254
+ A G + +L R +++ L+ + AEQ+R Q +LR E +A YA Q
Sbjct: 1389 KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQ----QLRAE------KASYAEQLS 1438
Query: 255 MLQLSQQLDASEQH---------KALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTA 305
ML+ + L A E + L+V+L Q R + L + +RA +E+ A
Sbjct: 1439 MLKKAHGLLAEENRGLGERANLGRQFLEVELD--QAREKYVQELAA--VRADAETRL--A 1492
Query: 306 ESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQM---QQGPEAHKE 362
E Q EA+ RE+ + + E+++R EE ++ Q Q+ Q+ E
Sbjct: 1493 EVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVE 1552
Query: 363 PPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDAS-MQCVLT-FEGLTNSKDSQAKKIKM 420
+ + ++ Q K++ + Q + Q+A +Q L + + K+ A+ K+
Sbjct: 1553 ELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKL 1612
Query: 421 DLQKAAT 427
++KA T
Sbjct: 1613 QMEKAKT 1619
Score = 52.4 bits (124), Expect = 1e-06
Identities = 87/396 (21%), Positives = 156/396 (39%), Gaps = 39/396 (9%)
Query: 121 QSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQ 180
Q G+K + + +L ++ E Q ++ + + +QLK E +E +
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR 578
Query: 181 HKEFQDLR---EVMEKSSRE---ALGHQEKLKAEHRHRAKILNLKL------REAEQQRV 228
Q L E E S RE AL E L+ E + +IL +L R++ Q V
Sbjct: 579 QDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSV 638
Query: 229 KQAEQERLRKEEGQIRLRAL--------YALQEEMLQLSQQLDASEQHKALLKVDLAAFQ 280
QA++E+ L+A + Q ++ +L QL SEQ KA K +A +
Sbjct: 639 TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL-RSEQQKATEKERVAQEK 697
Query: 281 TRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQ- 339
+QL + + + + E + A AL E + + L E E +R+
Sbjct: 698 ---DQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRER 754
Query: 340 ---DEEEAQVKLQEAQMQQGPEAH-------KEPPAPSQGPGGKQNEDLQVKVQDIT--M 387
+EE A K EA++QQ EAH + A + + + V+++
Sbjct: 755 KELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWR 814
Query: 388 QWYQQLQDASMQCVLTFEGLTNSKDSQAKKIKMDLQKA--ATIPVSQISTIAGSKLKEIF 445
+ Y+ Q Q F+ + + +K + +LQ+A + S + S+ +
Sbjct: 815 ERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNEL 874
Query: 446 DKIHSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKLA 481
++H+ L+ Q + V L +Q K+A
Sbjct: 875 AELHANLARALQQVQEKEVRAQKLADDLSTLQEKMA 910
Score = 51.2 bits (121), Expect = 3e-06
Identities = 52/209 (24%), Positives = 101/209 (48%), Gaps = 23/209 (11%)
Query: 179 KQHKEFQDLRE-VMEKSSR--EALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQER 235
+Q +E L++ EK ++ + L QE+ RH+ + L+ L++ EQQ + AE++
Sbjct: 516 QQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE 575
Query: 236 LRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIR 295
+++ +L A +E L ++ A +Q +AL K A + QL ++ R
Sbjct: 576 ATRQDHAQQLAT--AAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL--QVANEAR 631
Query: 296 ASSESSYPTAESQ-AEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQ 354
S+++S A+ + AE R + E++ AC + RQ++ EAQ ++ E ++Q
Sbjct: 632 DSAQTSVTQAQREKAELSRKVEELQ------------ACVETARQEQHEAQAQVAELELQ 679
Query: 355 QGPEAHKEPPAPSQGPGGKQNEDLQVKVQ 383
E K A + ++ + LQ ++Q
Sbjct: 680 LRSEQQK---ATEKERVAQEKDQLQEQLQ 705
Score = 48.9 bits (115), Expect = 2e-05
Identities = 70/285 (24%), Positives = 129/285 (45%), Gaps = 41/285 (14%)
Query: 153 EQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSRE-ALGHQEKLKAEHRH 211
E+E K Q L+++ + + E +EL+Q + L+E + K +E A G + +A R
Sbjct: 1058 EKEGKDQELAKLRGLEAAQIKELEELRQ--TVKQLKEQLAKKEKEHASGSGAQSEAAGRT 1115
Query: 212 -----RAKILNLKLREAEQQRVKQAEQ----ERLRKEEGQIRLR---ALYALQEEMLQLS 259
+ + L ++ + EQQ KQ EQ ER + E R AL LQ ++ + +
Sbjct: 1116 EPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKA 1175
Query: 260 QQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMR 319
Q+L S+ A + +LAAF+T+ + +A E A + EAER
Sbjct: 1176 QELGHSQSALASAQRELAAFRTK-------VQDHSKAEDEWKAQVARGRQEAER----KN 1224
Query: 320 DLLMNLGQEIT---RACEDKRRQDEEEAQVKLQEAQMQQGPEAH----KEPPAPSQGPGG 372
L+ +L +E++ R +K + +E ++ + E++ Q E + A +
Sbjct: 1225 SLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAA 1284
Query: 373 KQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKK 417
+++ L+ +VQ + ++A Q V + E L SQA++
Sbjct: 1285 ERSSALREEVQSLR-------EEAEKQRVAS-ENLRQELTSQAER 1321
Score = 44.7 bits (104), Expect = 3e-04
Identities = 77/364 (21%), Positives = 144/364 (39%), Gaps = 36/364 (9%)
Query: 94 AFSPASPATPNGTKGKDESQHTE-SMVLQSSRGIKVEGCVRMYELVHRMKGTEG-----L 147
A SP P + K+ES L+ + +K E +M ++++ G L
Sbjct: 269 AASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKS-QMDRKINQLSEENGDLSFKL 327
Query: 148 RLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGH--QEKL 205
R + ++ AL+E+ E K EW E + E + + +K E Q KL
Sbjct: 328 REFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKL 387
Query: 206 KAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDAS 265
H +++ + +E + + E L++E A A LQ ++ +
Sbjct: 388 SQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEA------ATLAANNTQLQARVEMLET 441
Query: 266 E--QHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLM 323
E Q +A L + F+ QL SLI+ + + S S E + ++ + +
Sbjct: 442 ERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVA 501
Query: 324 NLGQEITRACEDKRRQDEEEAQVK--------------LQEAQMQQGPEAHKEPPAPSQG 369
+L E+T ++QD+E A +K Q+ Q QG E + S
Sbjct: 502 SLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLK 561
Query: 370 PGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKIK-MDLQKAATI 428
+Q +++ K + QQL A+ + E +D+ K+++ ++ +KAA +
Sbjct: 562 QKEQQLKEVAEKQEATRQDHAQQLATAAEE----REASLRERDAALKQLEALEKEKAAKL 617
Query: 429 PVSQ 432
+ Q
Sbjct: 618 EILQ 621
Score = 40.8 bits (94), Expect = 0.004
Identities = 81/346 (23%), Positives = 142/346 (41%), Gaps = 67/346 (19%)
Query: 145 EGLRLWQEEQERKVQALSEMASEQLKRFDEWKEL---KQHKEFQDL--------REVMEK 193
E L +EE E+ Q L E A E++ + EL +Q E +L ++V EK
Sbjct: 833 EQLMTLKEECEKARQELQE-AKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEK 891
Query: 194 SSR------EALGHQEKLKAEHRHRAKILNLKLREAEQQ------------RVKQAEQER 235
R + QEK+ A + A++ L + EQQ R + E
Sbjct: 892 EVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEW 951
Query: 236 LRKEEGQ---IRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQ---LCSL 289
L +++G+ AL A++ E Q+ +L+ AL++ + RG Q + L
Sbjct: 952 LEEQQGRQFCSTQAALQAMEREAEQMGNELE--RLRAALMESQGQQQEERGQQEREVARL 1009
Query: 290 ISGIIRASSE---SSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQV 346
RA ++ AE + + AL E R L + + A +K +D+E A++
Sbjct: 1010 TQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKL 1069
Query: 347 K-LQEAQMQQGPE------------AHKEPPAPSQG-----------PGGKQNEDLQVKV 382
+ L+ AQ+++ E A KE S P G + E L+ +V
Sbjct: 1070 RGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEV 1129
Query: 383 QDITMQWYQQLQDA-SMQCVLTFEGLTNS-KDSQAKKIKMDLQKAA 426
+ Q +Q + A S++ L E + + +DS + ++ L++ A
Sbjct: 1130 SKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKA 1175
Score = 38.9 bits (89), Expect = 0.016
Identities = 62/299 (20%), Positives = 126/299 (42%), Gaps = 37/299 (12%)
Query: 151 QEEQERKVQALSEMASEQ--LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLK-- 206
++E ERK +S + E L R + L++ E ++L+ ++ S ++ +E+L+
Sbjct: 1217 RQEAERKNSLISSLEEEVSILNR----QVLEKEGESKELKRLVMAESEKSQKLEERLRLL 1272
Query: 207 ----AEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQL 262
A + RA + LRE Q ++AE++R+ E + + L + E +L Q+L
Sbjct: 1273 QAETASNSARAAERSSALREEVQSLREEAEKQRVASENLR---QELTSQAERAEELGQEL 1329
Query: 263 DASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALRE----- 317
A ++ + L+ Q +L+S ++ A AE QA AE+ RE
Sbjct: 1330 KAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAE-QAAAEKRHREELEQS 1388
Query: 318 ------MRDLLMNLGQEI-------TRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPP 364
+R L+ +E+ + E +R + A+ Q+ +AH
Sbjct: 1389 KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLA 1448
Query: 365 APSQGPGGKQN---EDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKIKM 420
++G G + N + L+V++ ++ Q+L + S A+++++
Sbjct: 1449 EENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEV 1507
Score = 32.7 bits (73), Expect = 1.2
Identities = 44/203 (21%), Positives = 88/203 (43%), Gaps = 37/203 (18%)
Query: 204 KLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQ---IRLRALYALQEEML---- 256
+++ E + A+ L + + E +VK E+ + +EE Q ++ L Q E
Sbjct: 1493 EVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVE 1552
Query: 257 QLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALR 316
+LS++L S+Q + + L A Q +G ESQ EA+R
Sbjct: 1553 ELSKKLADSDQASKVQQQKLKAVQAQGG---------------------ESQQEAQRLQA 1591
Query: 317 EMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNE 376
++ +L L Q+ A K + ++ + +A+ QQ E ++ + Q K+N+
Sbjct: 1592 QLNELQAQLSQKEQAAEHYKLQMEKAKTH---YDAKKQQNQELQEQLRSLEQLQ--KENK 1646
Query: 377 DLQVKVQDITMQWYQQLQDASMQ 399
+L+ + + + +LQ A ++
Sbjct: 1647 ELRAEAERLG----HELQQAGLK 1665
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 57.0 bits (136), Expect = 6e-08
Identities = 61/261 (23%), Positives = 111/261 (42%), Gaps = 30/261 (11%)
Query: 105 GTKGKDESQ---HTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQ----ERK 157
G G+ E Q E M Q + K E +M E +M+ E QEEQ E +
Sbjct: 192 GQMGEQEGQMGEQEEQMGEQEEQMQKQEE--QMGEQEEQMRKQEEQMGEQEEQVQKQEEQ 249
Query: 158 VQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILN 217
VQ E +Q ++ E +E + +E Q L++ + E G QE+ E + +
Sbjct: 250 VQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQE 309
Query: 218 LKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLA 277
++RE E+Q +Q EQ ++E+ + ++ +E+M + +Q+ E+
Sbjct: 310 EQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQ--------- 360
Query: 278 AFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKR 337
Q + Q +R E E + E +R+ + +G++ + E K
Sbjct: 361 -MQKQEEQ--------VRKQEEQMRKQEEQMRKQEEQMRKQEE---QMGEQKEQMGEQKE 408
Query: 338 RQDEEEAQVKLQEAQMQQGPE 358
+ E+E Q+ Q+ QM++ E
Sbjct: 409 QMREQEEQMGEQKEQMRKQEE 429
Score = 47.0 bits (110), Expect = 6e-05
Identities = 61/269 (22%), Positives = 116/269 (43%), Gaps = 24/269 (8%)
Query: 129 EGCVRMYELVHRMKGTEGLRLWQE----EQERKVQALSEMASEQLKRFDEWKELKQHKEF 184
EG VR E +++ EG QE EQE ++ EQ ++ E +E Q +E
Sbjct: 163 EGQVREQE--GQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEE 220
Query: 185 Q--DLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQ 242
Q + E M K E +G QE+ + + + ++R+ E+Q +Q EQ +R++E Q
Sbjct: 221 QMGEQEEQMRKQE-EQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQ--MREQEEQ 277
Query: 243 IRLRALYALQEEML-----QLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRAS 297
+ + QEE Q+ +Q + + + ++ + + Q+ +
Sbjct: 278 MLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE-Q 336
Query: 298 SESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDE----EEAQVKLQEAQM 353
E + E + E + E + + +++ + E R+Q+E +E Q++ QE QM
Sbjct: 337 KEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQM 396
Query: 354 QQGPE---AHKEPPAPSQGPGGKQNEDLQ 379
+ E KE + G+Q E ++
Sbjct: 397 GEQKEQMGEQKEQMREQEEQMGEQKEQMR 425
Score = 45.8 bits (107), Expect = 1e-04
Identities = 63/273 (23%), Positives = 109/273 (39%), Gaps = 42/273 (15%)
Query: 129 EGCVRMYELVHRMKGTEGLRLWQE----EQERKVQALSEMASEQLKRFDEWKELKQHKEF 184
EG VR E +++ EG QE EQE +V+ EQ + E + + +E
Sbjct: 128 EGQVREQE--GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 185
Query: 185 QDLREVMEKSSREA-LGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQ-----ERLRK 238
Q + + +E +G QE+ E + + ++ E E+Q KQ EQ E+++K
Sbjct: 186 QVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQK 245
Query: 239 EEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASS 298
+E Q++ + ++E Q+ EQ + +LK Q
Sbjct: 246 QEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQ-----------------E 288
Query: 299 ESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPE 358
E + E E E +RE + + E + + E+E Q+ QE QM + E
Sbjct: 289 EQTGEQEEQMREQEEQMREQEEQMR----------EQEEQMREQEEQMGKQEEQMWEQKE 338
Query: 359 ---AHKEPPAPSQGPGGKQNEDLQVKVQDITMQ 388
KE + G+Q E +Q + + + Q
Sbjct: 339 QMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQ 371
Score = 44.7 bits (104), Expect = 3e-04
Identities = 53/264 (20%), Positives = 113/264 (42%), Gaps = 31/264 (11%)
Query: 129 EGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLR 188
EG VR E +M EG QEEQ + + + EQ+ +E KQ ++ +
Sbjct: 184 EGQVREQE--GQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMR-KQEEQMGEQE 240
Query: 189 EVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRAL 248
E ++K + +E+++ + + ++RE E+Q +KQ EQ ++ G+
Sbjct: 241 EQVQKQEEQVQKQEEQMRKQEEQMRE-QEEQMREQEEQMLKQKEQTEQEEQTGE------ 293
Query: 249 YALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQ 308
QEE Q+ +Q + + + ++ + + Q+ E + E
Sbjct: 294 ---QEE--QMREQEEQMREQEEQMREQEEQMREQEEQMGK--------QEEQMWEQKEQM 340
Query: 309 AEAERALREMRDLLMNLGQEITRACEDKRRQDE----EEAQVKLQEAQMQQGPEAHKEPP 364
E + + + + + +++ + E R+Q+E +E Q++ QE QM++ +E
Sbjct: 341 WEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRK----QEEQM 396
Query: 365 APSQGPGGKQNEDLQVKVQDITMQ 388
+ G+Q E ++ + + + Q
Sbjct: 397 GEQKEQMGEQKEQMREQEEQMGEQ 420
Score = 41.2 bits (95), Expect = 0.003
Identities = 40/164 (24%), Positives = 76/164 (46%), Gaps = 15/164 (9%)
Query: 107 KGKDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMAS 166
K K++++ E Q + + E +R E +M+ E QEEQ K + E
Sbjct: 280 KQKEQTEQEEQTGEQEEQMREQEEQMREQE--EQMREQEEQMREQEEQMGKQE---EQMW 334
Query: 167 EQLKRFDEWKEL--KQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAE 224
EQ ++ E KE KQ ++ + E M+K + +E+++ + ++R+ E
Sbjct: 335 EQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEE--------QMRKQE 386
Query: 225 QQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQH 268
+Q KQ EQ +KE+ + + +E+M + +Q+ E+H
Sbjct: 387 EQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEH 430
Score = 37.4 bits (85), Expect = 0.047
Identities = 64/305 (20%), Positives = 122/305 (40%), Gaps = 22/305 (7%)
Query: 100 PATPNGTKGKDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQE----EQE 155
P G + E Q E Q + + EG VR E +++ EG QE EQE
Sbjct: 47 PLPQEGQVREQEGQVRE----QEGQVREQEGQVREQE--GQVREQEGQVREQEGQVREQE 100
Query: 156 RKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKI 215
+V+ EQ + E + + +E Q +RE E RE G + + + R +
Sbjct: 101 GQVREQEGQVREQEGQVREQEGQVREQEGQ-VRE-QEGQVREQEGQVREQEGQVREQEGQ 158
Query: 216 LNLKLREAEQQRVKQAEQE-RLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKV 274
+ + + +Q + EQE ++R++EGQ+R + ++E Q+ EQ + + K
Sbjct: 159 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQ 218
Query: 275 DLAAFQT-----RGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEI 329
+ + + + ++ E E + E +RE + + +++
Sbjct: 219 EEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQM 278
Query: 330 TRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQW 389
+ ++ Q E+E Q QE QM++ E +E + + E + + W
Sbjct: 279 LK----QKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMW 334
Query: 390 YQQLQ 394
Q+ Q
Sbjct: 335 EQKEQ 339
Score = 35.0 bits (79), Expect = 0.24
Identities = 22/92 (23%), Positives = 44/92 (47%), Gaps = 1/92 (1%)
Query: 148 RLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKA 207
++W++E++ Q E+ R E + KQ ++ + E M K E +G Q++
Sbjct: 346 QMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQE-EQMGEQKEQMG 404
Query: 208 EHRHRAKILNLKLREAEQQRVKQAEQERLRKE 239
E + + + ++ E ++Q KQ E +KE
Sbjct: 405 EQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 34.3 bits (77), Expect = 0.40
Identities = 51/262 (19%), Positives = 109/262 (41%), Gaps = 29/262 (11%)
Query: 176 KELKQ-HKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQE 234
+ELK+ + E Q+ +++E E H ++LK R+ E ++ ++
Sbjct: 7 EELKEKNAELQEELQLVETEKSEIQLHIKELK--------------RKLETDKIPLPQEG 52
Query: 235 RLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGII 294
++R++EGQ+R + ++E Q+ EQ + + + + G G +
Sbjct: 53 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ--VREQEGQV 110
Query: 295 RASS----ESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQE 350
R E E + + ++R+ + ++ + E + + E+E QV+ QE
Sbjct: 111 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 170
Query: 351 AQM--QQGPEAHKEPPAPSQ-GPGGKQ-----NEDLQVKVQDITMQWYQQLQDASMQCVL 402
Q+ Q+G +E Q G G+Q ++ Q+ Q+ MQ ++ + +
Sbjct: 171 GQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMR 230
Query: 403 TFEGLTNSKDSQAKKIKMDLQK 424
E ++ Q +K + +QK
Sbjct: 231 KQEEQMGEQEEQVQKQEEQVQK 252
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 56.2 bits (134), Expect = 1e-07
Identities = 60/244 (24%), Positives = 105/244 (43%), Gaps = 18/244 (7%)
Query: 152 EEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREAL--GHQEKLKAEH 209
+EQ RK Q L + E+L+R + K +Q +E Q E + E L +EK + +
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955
Query: 210 RHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHK 269
R R + KL++ E+Q + + ++R R+E Y +EE+ Q +QL E+ K
Sbjct: 956 RERQYRKDKKLQQKEEQLLGEEPEKRRRQER-----EKKYREEEELQQEEEQLLREEREK 1010
Query: 270 ALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEI 329
+ + + ++L ++R E E ER RE +L Q +
Sbjct: 1011 R-RRQEWERQYRKKDELQQEEEQLLREEREK-----RRLQERERQYREEEELQQEEEQLL 1064
Query: 330 TRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQW 389
E +RRQ+ E K +E Q ++ +EP +Q + Q + ++ Q
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRR-----RQERERQCREEEELQQE 1119
Query: 390 YQQL 393
+QL
Sbjct: 1120 EEQL 1123
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/239 (22%), Positives = 113/239 (47%), Gaps = 11/239 (4%)
Query: 126 IKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMA-SEQLKRFDEWKELKQHKEF 184
++ E R ++ R + EG R QE++E++ + SE+ E+ + + +E +Q ++F
Sbjct: 708 LESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDF 767
Query: 185 QDLREVMEKSSREALGHQEKLKAE---HRHRAKILNLKLREAEQQRV--KQAEQERLRKE 239
+ EKS R +++L A R + L + R+ +QR ++ E+E+ R++
Sbjct: 768 TWQWQAEEKSERG----RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQ 823
Query: 240 EGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSE 299
+ + +EE LQ ++ ++ + L+ D +++ + + +
Sbjct: 824 RREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERK 883
Query: 300 SSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPE 358
T ++ + LR+ + LL +E+ R +KRR+ E+E Q + +E Q+QQ E
Sbjct: 884 RRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR-EEEQLQQEEE 941
Score = 55.8 bits (133), Expect = 1e-07
Identities = 60/264 (22%), Positives = 120/264 (45%), Gaps = 23/264 (8%)
Query: 133 RMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVME 192
R+ E R + E + E+Q R+ + ++ E+ ++F E ++L Q +E Q L +
Sbjct: 1582 RLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR--Q 1639
Query: 193 KSSREALGHQEKLKAEHRHRA---------KILNLKLREAEQQRVKQAEQER-LRKEEGQ 242
+ R+ L + +L+ + R + + L+E E+Q++++ E++R R+EE Q
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ 1699
Query: 243 IRL--RALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSES 300
+R R LQEE Q+L+ + + L+ + Q R + I E
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI-----LEEEQ 1754
Query: 301 SYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAH 360
P E Q + R+ RD +++ + E+++ + +E + +E Q++Q E
Sbjct: 1755 LRPEREEQ----QLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQ 1810
Query: 361 KEPPAPSQGPGGKQNEDLQVKVQD 384
+ P G + E LQ++ Q+
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQE 1834
Score = 55.1 bits (131), Expect = 2e-07
Identities = 70/268 (26%), Positives = 113/268 (42%), Gaps = 47/268 (17%)
Query: 151 QEEQERKVQAL---------SEMASEQLKRFDEWKELKQHKEFQDLREVMEKS-----SR 196
QEE+ER Q L E EQL + +E K L+Q + Q L+ E+ R
Sbjct: 522 QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKR 581
Query: 197 EALGHQEKLKAEHRHRAK-------ILNLKLREAEQQRVKQAEQE-----RLRKEEGQIR 244
E Q++LK E R + + L+ E +QR+K+ E E +L K E Q
Sbjct: 582 EEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641
Query: 245 LRALYALQEEMLQLSQQLDASEQHKAL---LKVDLAAFQTRGNQLCSLISGIIRASSESS 301
R +E+ + Q+L E+ + L LK + + R +L R +S
Sbjct: 642 RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE-ERREQELAEEEQEQARERIKSR 700
Query: 302 YPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHK 361
P + Q E+E R+ + QE R +R++ EE+ + + E Q Q+ AH+
Sbjct: 701 IPKWQWQLESEADARQSKVYSRPRKQEGQR----RRQEQEEKRRRRESELQWQEEERAHR 756
Query: 362 EPPAPSQGPGGKQNEDLQVKVQDITMQW 389
+ +Q E+ + +D T QW
Sbjct: 757 Q----------QQEEEQR---RDFTWQW 771
Score = 54.3 bits (129), Expect = 4e-07
Identities = 58/231 (25%), Positives = 101/231 (43%), Gaps = 30/231 (12%)
Query: 133 RMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVME 192
R Y +++ E L +E ++R+ Q E+ K++ E +EL+Q +E Q LRE E
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQ-------EREKKYREEEELQQEEE-QLLREERE 1009
Query: 193 KSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQ 252
K R+ Q + K E + +E EQ ++ E+ RL++ E Q R +
Sbjct: 1010 KRRRQEWERQYRKKDELQ----------QEEEQLLREEREKRRLQERERQYR-------E 1052
Query: 253 EEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAE 312
EE LQ ++ E+ + + +L + +L ++R P + E E
Sbjct: 1053 EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE-----PEKRRRQERE 1107
Query: 313 RALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEP 363
R RE +L Q + E +RRQ+ E + +E Q ++ +EP
Sbjct: 1108 RQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP 1158
Score = 53.5 bits (127), Expect = 6e-07
Identities = 64/262 (24%), Positives = 113/262 (43%), Gaps = 24/262 (9%)
Query: 111 ESQHTESMVLQSSRGIKVEGCVRMYELVHR---MKGTEGLRLWQE--------EQERKVQ 159
E Q L+ + ++ E +R + + R ++ + LR QE EQER+ Q
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Query: 160 ALSEMASEQ---LKRFDEWKELKQHKEFQDLREVMEKSSRE---ALGHQEKLKAEHRHRA 213
L E+ LKR +E + +Q + Q L+ E+ RE L +E+ + + R
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ 505
Query: 214 KILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLK 273
++ + EQ+ +Q E+ERL Q RLR+ L+ E + +QL E+ K L +
Sbjct: 506 QLRREQEERREQRLKRQEEEERL-----QQRLRSEQQLRREQEERREQLLKREEEKRLEQ 560
Query: 274 VDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRAC 333
R + +++ E + + E R R+ + L QE R
Sbjct: 561 ERREQRLKREQE--ERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQ 618
Query: 334 EDKRRQDEEEAQVKLQEAQMQQ 355
KR + EEE + +L +++ Q+
Sbjct: 619 RLKREEPEEERRQQLLKSEEQE 640
Score = 52.8 bits (125), Expect = 1e-06
Identities = 65/274 (23%), Positives = 117/274 (42%), Gaps = 51/274 (18%)
Query: 151 QEEQERKVQAL----SEMASEQLKRFDEWKELKQH--------KEFQDLREVMEKSSREA 198
+E+QER+ Q L E ++LKR +E + L+Q +E ++ RE + K E
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556
Query: 199 LGHQEK----LKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEE 254
QE+ LK E R L + E QQR+K+ ++ERL + + + L +
Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR 616
Query: 255 MLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERA 314
+L ++ E+ + LLK + + R QL R E + + E ER
Sbjct: 617 EQRLKREEPEEERRQQLLKSE-EQEERRQQQL-------RREQQERREQRLKREEEEER- 667
Query: 315 LREMRDLLMNLGQEITRACEDKRRQDE--EEAQVKLQEA----------QMQQGPEAHKE 362
L Q + R E++RR+ E EE Q + +E Q++ +A +
Sbjct: 668 ----------LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQS 717
Query: 363 P----PAPSQGPGGKQNEDLQVKVQDITMQWYQQ 392
P +G +Q ++ + + ++ +QW ++
Sbjct: 718 KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751
Score = 51.2 bits (121), Expect = 3e-06
Identities = 66/295 (22%), Positives = 129/295 (43%), Gaps = 38/295 (12%)
Query: 107 KGKDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMAS 166
K +D E +L+ R K R E + + E L QER+ Q L
Sbjct: 1308 KRRDRKSQEEKQLLREEREEKR----RRQETDRKFREEEQLL-----QEREEQPLRRQER 1358
Query: 167 EQLKRFDEWKELKQHKEFQDLREVMEKSSREA--LGHQEKLKAEHRHRA--KILNLKLRE 222
++ R +E + +Q ++F + + + + RE L +++L+ + R + + + K RE
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFRE 1418
Query: 223 AEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTR 282
EQQ +Q + R+EE Q+R + + + L+ QQL E+H+ + + +
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQ---ERERKFLEEEQQL-RQERHRKFREEEQLLQERE 1474
Query: 283 GNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEE 342
QL R + + E Q + R+ R+ QE+ R+ E +R+ EE
Sbjct: 1475 EQQL-------HRQERDRKFLEEEQQLRRQERDRKFRE------QEL-RSQEPERKFLEE 1520
Query: 343 EAQVKLQEAQ---MQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQ 394
E Q+ Q+ Q +Q+ + ++ +G +Q+ D + + ++ Q ++ Q
Sbjct: 1521 EQQLHRQQRQRKFLQEEQQLRRQ----ERGQQRRQDRDRKFREEEQLRQEREEQQ 1571
Score = 50.4 bits (119), Expect = 5e-06
Identities = 52/218 (23%), Positives = 96/218 (44%), Gaps = 30/218 (13%)
Query: 151 QEEQERKVQAL-----SEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKL 205
++E+ER+ Q L E +QL+R + + +Q + Q LR + + L +++L
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 413
Query: 206 KAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDAS 265
+ E +LR +Q R +Q E+ +K E + R + L QEE ++ + +
Sbjct: 414 RREQ---------QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET 464
Query: 266 EQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNL 325
E+H+ + R QL E + + E R +E R+ +
Sbjct: 465 ERHEQ---------ERRKQQLKR------DQEEERRERWLKLEEEERREQQERREQQLRR 509
Query: 326 GQEITRACEDKRRQDEEEAQVKLQ-EAQMQQGPEAHKE 362
QE R KR+++EE Q +L+ E Q+++ E +E
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/227 (24%), Positives = 95/227 (41%), Gaps = 50/227 (22%)
Query: 145 EGLRLWQEEQERKV----QALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALG 200
E +L ++E ERK Q E EQL+R + ++++ + ++ + RE + +E
Sbjct: 1712 EEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQE--- 1768
Query: 201 HQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLR-----ALYALQEEM 255
K + E + R + +LR E R K E+E+LR+E + +LR Y +EE
Sbjct: 1769 RDRKFREEEQLRQEREEQQLRSQESDR-KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQ 1827
Query: 256 LQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERAL 315
LQL +Q EQ +R + Y E A E++
Sbjct: 1828 LQLEEQ----EQR-------------------------LRQERDRQYRAEEQFATQEKSR 1858
Query: 316 REMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKE 362
RE QE+ + E KRRQ+ E + + Q+ + H++
Sbjct: 1859 REE--------QELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQ 1897
Score = 48.9 bits (115), Expect = 2e-05
Identities = 51/206 (24%), Positives = 94/206 (45%), Gaps = 33/206 (16%)
Query: 154 QERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRA 213
Q+R+ + L E +QL+R + ++ +Q ++ + E + RE Q+ + E +
Sbjct: 1527 QQRQRKFLQE--EQQLRRQERGQQRRQDRDRKFREEEQLRQERE---EQQLSRQERDRKF 1581
Query: 214 KILNLKLREAEQQRVKQAEQERLRKEEGQIRLR----ALYALQEEMLQ--LSQQLDASEQ 267
++ K+R EQ+R ++++LR++EGQ +LR + E++LQ QQL E+
Sbjct: 1582 RLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641
Query: 268 HKALLKVD-LAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLG 326
+ L+ + Q R QL + + +R RE LL
Sbjct: 1642 DRKFLEEEPQLRRQEREQQL---------------------RHDRDRKFREEEQLLQEGE 1680
Query: 327 QEITRACEDKRRQDEEEAQVKLQEAQ 352
++ R E R+ EEE Q++ QE +
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERE 1706
Score = 48.1 bits (113), Expect = 3e-05
Identities = 58/237 (24%), Positives = 109/237 (45%), Gaps = 18/237 (7%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREV-MEKS 194
E + R + + R QE Q R+ + L + EQL R + K +Q +E Q ++ +++
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQ-EEEQLLREEREKRRRQERERQYRKDKKLQQK 969
Query: 195 SREALGHQ-EKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQE 253
+ LG + EK + + R + +L++ E+Q +++ E+E+ R++E + + Y ++
Sbjct: 970 EEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE-EREKRRRQEWERQ----YRKKD 1024
Query: 254 EMLQLSQQLDASEQHKALLKV------DLAAFQTRGNQLCSLISGIIRASS-ESSYPTAE 306
E+ Q +QL E+ K L+ + Q QL R E Y E
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084
Query: 307 S-QAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKE 362
Q E E+ LRE + QE R C ++ +EE Q+ +E + ++ E ++
Sbjct: 1085 ELQQEEEQLLREEPE--KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQ 1139
Score = 47.4 bits (111), Expect = 5e-05
Identities = 54/270 (20%), Positives = 117/270 (43%), Gaps = 19/270 (7%)
Query: 111 ESQHTESMVLQSSRGIKVEGC-----VRMYELVH-RMKGTEGL---------RLWQEEQE 155
E + E LQS +G + E +R EL+ R KG E R++QEE+E
Sbjct: 184 EERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEE 243
Query: 156 ---RKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHR 212
RK + + E+L+ + ++ + +E + LR++ + R +E+ + R
Sbjct: 244 KEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRRE 303
Query: 213 AKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALL 272
++ + E +Q+ ++ EQ+ R+++ + R + L QEE + + + E+ +
Sbjct: 304 QQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE-Q 362
Query: 273 KVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRA 332
++ + R Q + R + + R + R+ + Q++ R
Sbjct: 363 QLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 422
Query: 333 CEDKRRQDEEEAQVKLQEAQMQQGPEAHKE 362
+ +R Q+EE + K ++ + +Q + +E
Sbjct: 423 QQLRREQEEERHEQKHEQERREQRLKREQE 452
Score = 46.2 bits (108), Expect = 1e-04
Identities = 67/262 (25%), Positives = 101/262 (38%), Gaps = 37/262 (14%)
Query: 137 LVHRMKGTEGLRLWQE---EQERKVQALSEMASEQLKRFDEWKELKQ---HKEFQDLREV 190
L R+K E RL QE EQ K + E +QL + +E +E +Q +E Q+ RE
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Query: 191 MEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVK----------QAEQE------ 234
K E +++LK EH + L E EQ R + Q E E
Sbjct: 658 RLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQS 717
Query: 235 ----RLRKEEGQIRLR----------ALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQ 280
R RK+EGQ R + + QEE QQ + ++ +
Sbjct: 718 KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKS 777
Query: 281 TRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQD 340
RG Q S +R E E Q +R L E + Q R E + ++
Sbjct: 778 ERGRQRLS-ARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEE 836
Query: 341 EEEAQVKLQEAQMQQGPEAHKE 362
EE+ Q + + Q+Q+ + +E
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQE 858
Score = 44.7 bits (104), Expect = 3e-04
Identities = 58/242 (23%), Positives = 108/242 (44%), Gaps = 23/242 (9%)
Query: 113 QHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRF 172
Q E L+ + ++ E + E ++ E +L ++E++RK L E +QL+R
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKF--LEE--EQQLRRQ 1497
Query: 173 DEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAE 232
+ ++ ++ Q+LR ++ R+ L +++L + R R K L + + Q+R +Q
Sbjct: 1498 ERDRKFRE----QELRS--QEPERKFLEEEQQLHRQQRQR-KFLQEEQQLRRQERGQQRR 1550
Query: 233 QERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISG 292
Q+R RK + +LR + E QLS+Q K L+ Q + +
Sbjct: 1551 QDRDRKFREEEQLRQ----EREEQQLSRQ---ERDRKFRLEEQKVRRQEQERKFMEDEQQ 1603
Query: 293 IIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQ 352
+ R + + + E +R RE LL ++ E R+ EEE Q++ QE +
Sbjct: 1604 LRRQEGQQ-----QLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658
Query: 353 MQ 354
Q
Sbjct: 1659 QQ 1660
Score = 42.7 bits (99), Expect = 0.001
Identities = 52/226 (23%), Positives = 100/226 (44%), Gaps = 30/226 (13%)
Query: 150 WQEEQERKVQA----LSEMASEQLKRFDEWKELKQHKEFQDLREVM-EKSSREA------ 198
W+ E+E V+ +EQ ++ ++ +L+ + QDL+ ++ E+ R+
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLED-SQLRDRQSQQDLQHLLGEQQERDREQERRR 1285
Query: 199 -------LGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYAL 251
+E+L+ E + AK + K +E +Q ++ E++R R+E + +
Sbjct: 1286 WQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDR-----KFRE 1340
Query: 252 QEEMLQ--LSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQ- 308
+E++LQ Q L E+ + + +L Q +G + + R E + E Q
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEEL-RHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399
Query: 309 --AEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQ 352
E E+ LR+ RD ++ E R+ EEE QV+ QE +
Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE 1445
Score = 42.4 bits (98), Expect = 0.001
Identities = 56/225 (24%), Positives = 97/225 (43%), Gaps = 20/225 (8%)
Query: 152 EEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGH--QEKLKAEH 209
EEQ K + L E Q + + W++ ++ +E ++ R E+ + GH +E E
Sbjct: 152 EEQSEKQERL-EQRDRQRRDEELWRQRQEWQEREE-RRAEEEQLQSCKGHETEEFPDEEQ 209
Query: 210 RHRAKILNL--KLREAEQQ-------RVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQ 260
R ++L L K RE +QQ RV Q E+E+ ++ + + LQEE Q +
Sbjct: 210 LRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQR 269
Query: 261 QL-DASEQHKALLKVDLAAFQTRGNQLCSLI---SGIIRASSESSYPTAE---SQAEAER 313
+L + EQ + L + +L + Q + + R E E Q E
Sbjct: 270 ELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329
Query: 314 ALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPE 358
E R+ + QE R + +R Q+EE + +L+ Q ++ E
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Score = 42.4 bits (98), Expect = 0.001
Identities = 40/172 (23%), Positives = 82/172 (47%), Gaps = 18/172 (10%)
Query: 113 QHTESMVLQSSRGIKVEGCVRMYELVHRMKG-TEGLRLWQEEQERKV----QALSEMASE 167
Q E LQ + ++ + R + +++ TE +L ++E+ RK+ Q E +
Sbjct: 1703 QERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ 1762
Query: 168 QLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQR 227
QL+R + ++ ++ ++ + RE + S+E+ K + E + R + +LR ++
Sbjct: 1763 QLRRQERDRKFREEEQLRQEREEQQLRSQES---DRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 228 VKQAEQERLRKEEGQIRLR----------ALYALQEEMLQLSQQLDASEQHK 269
+ E+E+L+ EE + RLR +A QE+ + Q+L E+ K
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871
Score = 41.2 bits (95), Expect = 0.003
Identities = 49/212 (23%), Positives = 88/212 (41%), Gaps = 32/212 (15%)
Query: 151 QEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
QEE +R+ + E+ + K +Q +E + E EK QE+L+ R
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEK--------QERLEQRDR 166
Query: 211 HRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQE----------EMLQLSQ 260
R E +QR + E+E R EE Q++ + +E E+L+L +
Sbjct: 167 QRRD------EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRR 220
Query: 261 QLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRD 320
+ +Q + + D FQ + ++R E E + + +R L+E +
Sbjct: 221 KGREEKQQQRRERQD-RVFQEEEEKEWRKRETVLRKEEEK---LQEEEPQRQRELQEEEE 276
Query: 321 LLMNLGQEITRACEDKRRQDEEEAQVKLQEAQ 352
L L ++ R + RQ+EE+ Q +L+ Q
Sbjct: 277 QLRKLERQELR----RERQEEEQQQQRLRREQ 304
Score = 38.5 bits (88), Expect = 0.021
Identities = 34/134 (25%), Positives = 64/134 (47%), Gaps = 11/134 (8%)
Query: 132 VRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVM 191
+R E + + E LR +EEQ+ + Q E ++F E ++L+Q +E Q LR
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQ-------ESDRKFREEEQLRQEREEQQLRPQQ 1816
Query: 192 EKSS----REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRA 247
E L +E+ + + R + + + A Q++ ++ EQE ++EE + R
Sbjct: 1817 RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQER 1876
Query: 248 LYALQEEMLQLSQQ 261
L+EE ++ Q+
Sbjct: 1877 ERKLREEHIRRQQK 1890
Score = 38.1 bits (87), Expect = 0.028
Identities = 49/216 (22%), Positives = 97/216 (44%), Gaps = 27/216 (12%)
Query: 149 LWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAE 208
L QEE++ + + ++L+R +E Q +E Q LRE EK R+ L Q + + E
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175
Query: 209 HRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLS--QQLDASE 266
L++ E+Q +++ +++R ++ E Q R +EE LQ +Q E
Sbjct: 1176 -----------LQQEEEQLLREEQEKRRQERERQYR-------EEEELQRQKRKQRYRDE 1217
Query: 267 QHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLG 326
++ LK +Q + ++ + + + + R + +DL LG
Sbjct: 1218 DQRSDLK-----WQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLG 1272
Query: 327 QEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKE 362
++ R E +RR+ ++ + +E Q+++ E KE
Sbjct: 1273 EQQERDREQERRRWQQRDRHFPEEEQLER--EEQKE 1306
Score = 35.0 bits (79), Expect = 0.24
Identities = 36/120 (30%), Positives = 59/120 (49%), Gaps = 12/120 (10%)
Query: 132 VRMYELVHRMKGTEGLRLWQEEQERKVQALS---EMASEQLKRFDEWKELKQHKEFQDLR 188
+R E + + E LR +EEQ+ + Q EQL+ ++ + L+Q ++ Q
Sbjct: 1788 LRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRA 1847
Query: 189 E----VMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIR 244
E EKS RE QE + E + R + KLRE E R +Q E++R ++ G+I+
Sbjct: 1848 EEQFATQEKSRRE---EQELWQEEEQKRRQERERKLRE-EHIRRQQKEEQR-HRQVGEIK 1902
Score = 33.9 bits (76), Expect = 0.52
Identities = 51/228 (22%), Positives = 90/228 (39%), Gaps = 36/228 (15%)
Query: 148 RLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGH-----Q 202
+L +E+QER+ Q L E+ +E ++ + Q+L E ++ +RE + Q
Sbjct: 646 QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQ 705
Query: 203 EKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRK------------------EEGQIR 244
+L++E R + + R+ E QR +Q ++E+ R+ EE Q R
Sbjct: 706 WQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRR 765
Query: 245 LRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPT 304
+ Q + SE+ + L + R QL R E +
Sbjct: 766 ---------DFTWQWQAEEKSERGRQRLSARPPLREQRERQL----RAEERQQREQRFLP 812
Query: 305 AESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQ 352
E + E R R R+ + +E + +R Q +E + LQE Q
Sbjct: 813 EEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQ 860
Score = 32.0 bits (71), Expect = 2.0
Identities = 21/62 (33%), Positives = 32/62 (51%), Gaps = 7/62 (11%)
Query: 145 EGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEK 204
E LWQEE++++ Q E+ ++ E +Q KE Q R+V E S+E GH
Sbjct: 1860 EEQELWQEEEQKRRQ-------ERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRL 1912
Query: 205 LK 206
L+
Sbjct: 1913 LE 1914
Score = 31.6 bits (70), Expect = 2.6
Identities = 46/242 (19%), Positives = 98/242 (40%), Gaps = 41/242 (16%)
Query: 179 KQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQA---EQER 235
++ +E Q E ++ E G + + K + + R +L E E+Q KQ +++R
Sbjct: 113 RRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQER------ELAEGEEQSEKQERLEQRDR 166
Query: 236 LRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIR 295
R++E R R + +EE +QL + + H+
Sbjct: 167 QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET------------------------- 201
Query: 296 ASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQ 355
+P E E L E+R Q+ R +D+ Q+EEE + + +E +++
Sbjct: 202 ----EEFPDEEQLRRRE--LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRK 255
Query: 356 GPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQA 415
E +E Q ++ E L+ K++ ++ +Q ++ Q + + L ++ +
Sbjct: 256 EEEKLQEEEPQRQRELQEEEEQLR-KLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314
Query: 416 KK 417
++
Sbjct: 315 RE 316
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 55.8 bits (133), Expect = 1e-07
Identities = 63/230 (27%), Positives = 107/230 (46%), Gaps = 28/230 (12%)
Query: 151 QEEQERKVQ--ALSEMASEQLKRFDEWKELKQHKEFQ---DLREVMEKSS---REALGHQ 202
+EE ER+ Q A +E A E+ +R E +LK ++ + EV ++ S EA +
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 203 EKLKAEHRHRAKILNLKLRE---AEQQRVKQAE------QERLRKEEGQIRLRA------ 247
E+ + E R R K +R+ AEQ+ KQ + Q+RL E+ IRLRA
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 248 --LYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTA 305
L+EE+ +L ++ A+ Q + L+ +LA + ++ L++ RA ES +
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1783
Query: 306 ESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQ 355
+S+ E R+L + A E KR++ E Q A+ ++
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1833
Score = 50.1 bits (118), Expect = 7e-06
Identities = 62/272 (22%), Positives = 114/272 (41%), Gaps = 17/272 (6%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
+E R E EL+ ++ Q L E+ REA +K A A+ L E E+
Sbjct: 1955 AEDTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 226 QRVKQAEQERLRKEEGQIRLRALYALQE---EMLQLSQQLD--ASEQHKALLKVDLAAFQ 280
+ K E RLR+ Q R L QE + LQ ++ A +Q + L+ L Q
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Query: 281 TRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDK---R 337
+ +QL RA+ E+ +++ EA ++ R++ + + + ++ E++ R
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-----AERLKQSAEEQAQAR 2128
Query: 338 RQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDAS 397
Q + A+ +EA+ + A E A Q + K + T++ Q++
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188
Query: 398 MQCVLTFEGLTNSK---DSQAKKIKMDLQKAA 426
L E + K D + +++K + +AA
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220
Score = 48.1 bits (113), Expect = 3e-05
Identities = 52/221 (23%), Positives = 97/221 (43%), Gaps = 19/221 (8%)
Query: 151 QEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
Q+E +RK QA E+AS E + +E Q + +E+ +A + +L+
Sbjct: 1504 QDESQRKRQAEVELASRVKA------EAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557
Query: 211 HRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLR--------ALYALQEEMLQLSQQL 262
RA+ + + L A++ + + +R E +L A+ L+EE + +QQ
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 263 DASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLL 322
+E+ + + +L +Q + N+ L + + S AE++ + E A RE R
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR--- 1674
Query: 323 MNLGQEITRACEDKRRQDEE-EAQVKLQEAQMQQGPEAHKE 362
G+ +A + ++E E Q +L E QQ A +E
Sbjct: 1675 -RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Score = 46.6 bits (109), Expect = 8e-05
Identities = 50/241 (20%), Positives = 107/241 (44%), Gaps = 41/241 (17%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
E + RM+ E L Q +ER+ A E A E+ ++ E + + ++ +E+ ++
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 196 REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRL--RALYALQE 253
E + +E + + I + E Q+++Q+ + ++ + Q R+ ++E
Sbjct: 1399 EEVVRREEAAVDAQQQKRSI------QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1452
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
E+ + QL+A+E+ + + +L A + R + E+ ++Q EAER
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALRAR--------------AEEAEAQKRQAQEEAER 1498
Query: 314 ALREMRD-----------LLMNLGQEITRACEDKR--------RQDEEEAQVKLQEAQMQ 354
R+++D L + E A E +R R EEA+ +L++A+++
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1558
Query: 355 Q 355
+
Sbjct: 1559 R 1559
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/282 (22%), Positives = 126/282 (44%), Gaps = 15/282 (5%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
SE L+R +E + L + + ++ + E + AL Q +L H + +E +Q
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEA--ALEKQRQLAEAHAQAKAQAEREAKELQQ 1395
Query: 226 QRVKQAEQERLRKEEGQIRLRALY-ALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGN 284
+ ++E +R+EE + + ++QEE+ QL Q +A Q KA + R
Sbjct: 1396 RM----QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 285 QLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEA 344
+ ++ + A +E AE + +A RA E + QE E RRQ ++E+
Sbjct: 1452 EEIRVVRLQLEA-TERQRGGAEGELQALRARAEEAEAQKRQAQE---EAERLRRQVQDES 1507
Query: 345 QVKLQEAQMQQGPEAHKEPPAPSQGPGGKQN-EDLQVKVQDITMQWYQQLQDASMQCVLT 403
Q K ++A+++ E A + Q E+L+++ ++ + Q + + Q +
Sbjct: 1508 QRK-RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 404 FEGLTNSKDSQAKKIKMDL-QKAATIPVS-QISTIAGSKLKE 443
E S +++ + + +K A + S Q +A ++L+E
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608
Score = 44.7 bits (104), Expect = 3e-04
Identities = 60/255 (23%), Positives = 103/255 (40%), Gaps = 18/255 (7%)
Query: 109 KDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQ 168
+DESQ ++ + +K E E ++ E LRL EE ER+++ + Q
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRV 228
++ E + E Q R + + + + L+ EH A++ R A+QQ
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERRAQQQ-- 1617
Query: 229 KQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCS 288
AE ER R EE + L E L+L Q + Q K+L + + A Q + +
Sbjct: 1618 --AEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE-AEKQKEEAEREA 1673
Query: 289 LISGIIRASSESSYPTAESQAEAERALRE--------MRDLLMNLGQEITRACEDKRRQD 340
G + AE + E +R L E L+ L E + + ++ +
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733
Query: 341 EEEAQVKLQEAQMQQ 355
EE A+++ + A Q
Sbjct: 1734 EELARLQREAAAATQ 1748
Score = 42.4 bits (98), Expect = 0.001
Identities = 66/226 (29%), Positives = 98/226 (43%), Gaps = 40/226 (17%)
Query: 141 MKGTEGLRLWQEEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQD-------LREVME 192
M+ + +L QE Q + LSE S Q +RF E ++ K + FQD LRE +
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535
Query: 193 KSSREALGHQEKLKAE------HRHRAKI-LNLKLREAEQQRVKQAEQERLRKEEGQIRL 245
+ ++ +++L A +H A+ + K E +Q ++ +QE L EE Q RL
Sbjct: 2536 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RL 2594
Query: 246 RALYALQEEMLQLSQQLDASEQHKALL-------KVDLAAFQTRGNQLCSLISGIIRASS 298
R E LQL + EQH+A L +AA +T N +L A
Sbjct: 2595 R-------EQLQLLE-----EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2642
Query: 299 ESSYPTAESQAEAERALREMRDL----LMNLGQEITRACEDKRRQD 340
E S+ + A+R L+E L L L Q T E RR+D
Sbjct: 2643 EHSFDGLRRKVSAQR-LQEAGILSAEELQRLAQGHTTVDELARRED 2687
Score = 40.8 bits (94), Expect = 0.004
Identities = 50/234 (21%), Positives = 104/234 (44%), Gaps = 20/234 (8%)
Query: 153 EQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHR 212
E ER ++EM+ Q + ++ + ++ E E+ EK R L QEK+
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHRTELATQEKVTL----- 2430
Query: 213 AKILNLKLREAEQ--QRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKA 270
+ L ++ ++++ +R+++A E R++E + L L+ E +Q QQ ++ +A
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 271 LLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEIT 330
L + +F + + L I + ++ + A+A++ E + + QE
Sbjct: 2491 LQQ----SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2546
Query: 331 RAC----EDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQV 380
R E +RRQ E E V+ ++ ++QQ + ++ + E LQ+
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2600
Score = 40.4 bits (93), Expect = 0.006
Identities = 65/286 (22%), Positives = 116/286 (40%), Gaps = 29/286 (10%)
Query: 152 EEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
EE+ R S+ E + RF E E E LR + E++ R+ +E +
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRA 1829
Query: 211 HRAKILNLKLRE-AEQQRVKQAEQERLRKEEGQI-RLRALYALQEEMLQLSQQLDASEQH 268
++L KL E R+K + L+++E + RLR L ++E Q + + + QH
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL--AEDEAFQRRRLEEQAAQH 1887
Query: 269 KALLKVDLAAFQTRGNQLCSLISGIIR--------------ASSESSYPTAESQAEAERA 314
KA ++ LA + + G++ A S A +AE E
Sbjct: 1888 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1947
Query: 315 LREMR----DLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGP 370
L +R D L + Q A ++ EEE + + E ++Q+ A +E A +
Sbjct: 1948 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE-AARQRKA 2006
Query: 371 GGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAK 416
++ E L+ KV++ + Q+++ Q L E ++ K
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Score = 39.3 bits (90), Expect = 0.012
Identities = 62/307 (20%), Positives = 141/307 (45%), Gaps = 28/307 (9%)
Query: 110 DESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQER-KVQALSEMASEQ 168
+E+ H ++++ + + +K E + + +R+ EE + K + +E +
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLK---------AEHRHRA-KILNL 218
L+ D + Q +E + +++V E+++R ++ QE + A+ R A K+L
Sbjct: 2256 LRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Query: 219 KLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAA 278
K++ ++ +AE E L++++ ++ LQE+ Q++QQL Q + L A
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQK-ELAQEQARRLQEDKEQMAQQLAEETQG---FQRTLEA 2370
Query: 279 FQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQ---------EI 329
+ R ++ + + +E S A ++ +A+R ++ ++ L + +
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 330 TRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQW 389
+ E +R+Q + +A+ +L+EA + E KE ++E++Q Q+ +Q
Sbjct: 2431 VQTLEIQRQQSDHDAE-RLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 390 YQQLQDA 396
Q LQ +
Sbjct: 2488 TQALQQS 2494
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 10/188 (5%)
Query: 145 EGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEK 204
E LR E ER+ + L + A + +E + ++Q + Q+ + + + E ++
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 205 LKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEE---------- 254
+ + +AK+ L E + + + EQ+R +++ Q R R + +++E
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Query: 255 MLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERA 314
+ + ++L EQ + + LA R + L+ RA+ S SQ A +
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 315 LREMRDLL 322
L RD L
Sbjct: 2626 LPNGRDAL 2633
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 55.8 bits (133), Expect = 1e-07
Identities = 63/230 (27%), Positives = 107/230 (46%), Gaps = 28/230 (12%)
Query: 151 QEEQERKVQ--ALSEMASEQLKRFDEWKELKQHKEFQ---DLREVMEKSS---REALGHQ 202
+EE ER+ Q A +E A E+ +R E +LK ++ + EV ++ S EA +
Sbjct: 1611 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1670
Query: 203 EKLKAEHRHRAKILNLKLRE---AEQQRVKQAE------QERLRKEEGQIRLRA------ 247
E+ + E R R K +R+ AEQ+ KQ + Q+RL E+ IRLRA
Sbjct: 1671 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730
Query: 248 --LYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTA 305
L+EE+ +L ++ A+ Q + L+ +LA + ++ L++ RA ES +
Sbjct: 1731 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1787
Query: 306 ESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQ 355
+S+ E R+L + A E KR++ E Q A+ ++
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1837
Score = 50.1 bits (118), Expect = 7e-06
Identities = 62/272 (22%), Positives = 114/272 (41%), Gaps = 17/272 (6%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
+E R E EL+ ++ Q L E+ REA +K A A+ L E E+
Sbjct: 1959 AEDTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2017
Query: 226 QRVKQAEQERLRKEEGQIRLRALYALQE---EMLQLSQQLD--ASEQHKALLKVDLAAFQ 280
+ K E RLR+ Q R L QE + LQ ++ A +Q + L+ L Q
Sbjct: 2018 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2077
Query: 281 TRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDK---R 337
+ +QL RA+ E+ +++ EA ++ R++ + + + ++ E++ R
Sbjct: 2078 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-----AERLKQSAEEQAQAR 2132
Query: 338 RQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDAS 397
Q + A+ +EA+ + A E A Q + K + T++ Q++
Sbjct: 2133 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2192
Query: 398 MQCVLTFEGLTNSK---DSQAKKIKMDLQKAA 426
L E + K D + +++K + +AA
Sbjct: 2193 TTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2224
Score = 48.1 bits (113), Expect = 3e-05
Identities = 52/221 (23%), Positives = 97/221 (43%), Gaps = 19/221 (8%)
Query: 151 QEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
Q+E +RK QA E+AS E + +E Q + +E+ +A + +L+
Sbjct: 1508 QDESQRKRQAEVELASRVKA------EAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1561
Query: 211 HRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLR--------ALYALQEEMLQLSQQL 262
RA+ + + L A++ + + +R E +L A+ L+EE + +QQ
Sbjct: 1562 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1621
Query: 263 DASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLL 322
+E+ + + +L +Q + N+ L + + S AE++ + E A RE R
Sbjct: 1622 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR--- 1678
Query: 323 MNLGQEITRACEDKRRQDEE-EAQVKLQEAQMQQGPEAHKE 362
G+ +A + ++E E Q +L E QQ A +E
Sbjct: 1679 -RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718
Score = 46.6 bits (109), Expect = 8e-05
Identities = 50/241 (20%), Positives = 107/241 (44%), Gaps = 41/241 (17%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
E + RM+ E L Q +ER+ A E A E+ ++ E + + ++ +E+ ++
Sbjct: 1343 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1402
Query: 196 REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRL--RALYALQE 253
E + +E + + I + E Q+++Q+ + ++ + Q R+ ++E
Sbjct: 1403 EEVVRREEAAVDAQQQKRSI------QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1456
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
E+ + QL+A+E+ + + +L A + R + E+ ++Q EAER
Sbjct: 1457 EIRVVRLQLEATERQRGGAEGELQALRAR--------------AEEAEAQKRQAQEEAER 1502
Query: 314 ALREMRD-----------LLMNLGQEITRACEDKR--------RQDEEEAQVKLQEAQMQ 354
R+++D L + E A E +R R EEA+ +L++A+++
Sbjct: 1503 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1562
Query: 355 Q 355
+
Sbjct: 1563 R 1563
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/282 (22%), Positives = 126/282 (44%), Gaps = 15/282 (5%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
SE L+R +E + L + + ++ + E + AL Q +L H + +E +Q
Sbjct: 1342 SETLRRMEEEERLAEQQRAEERERLAEVEA--ALEKQRQLAEAHAQAKAQAEREAKELQQ 1399
Query: 226 QRVKQAEQERLRKEEGQIRLRALY-ALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGN 284
+ ++E +R+EE + + ++QEE+ QL Q +A Q KA + R
Sbjct: 1400 RM----QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1455
Query: 285 QLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEA 344
+ ++ + A +E AE + +A RA E + QE E RRQ ++E+
Sbjct: 1456 EEIRVVRLQLEA-TERQRGGAEGELQALRARAEEAEAQKRQAQE---EAERLRRQVQDES 1511
Query: 345 QVKLQEAQMQQGPEAHKEPPAPSQGPGGKQN-EDLQVKVQDITMQWYQQLQDASMQCVLT 403
Q K ++A+++ E A + Q E+L+++ ++ + Q + + Q +
Sbjct: 1512 QRK-RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1570
Query: 404 FEGLTNSKDSQAKKIKMDL-QKAATIPVS-QISTIAGSKLKE 443
E S +++ + + +K A + S Q +A ++L+E
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1612
Score = 44.7 bits (104), Expect = 3e-04
Identities = 60/255 (23%), Positives = 103/255 (40%), Gaps = 18/255 (7%)
Query: 109 KDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQ 168
+DESQ ++ + +K E E ++ E LRL EE ER+++ + Q
Sbjct: 1508 QDESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQ 1566
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRV 228
++ E + E Q R + + + + L+ EH A++ R A+QQ
Sbjct: 1567 VQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERRAQQQ-- 1621
Query: 229 KQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCS 288
AE ER R EE + L E L+L Q + Q K+L + + A Q + +
Sbjct: 1622 --AEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE-AEKQKEEAEREA 1677
Query: 289 LISGIIRASSESSYPTAESQAEAERALRE--------MRDLLMNLGQEITRACEDKRRQD 340
G + AE + E +R L E L+ L E + + ++ +
Sbjct: 1678 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1737
Query: 341 EEEAQVKLQEAQMQQ 355
EE A+++ + A Q
Sbjct: 1738 EELARLQREAAAATQ 1752
Score = 42.4 bits (98), Expect = 0.001
Identities = 66/226 (29%), Positives = 98/226 (43%), Gaps = 40/226 (17%)
Query: 141 MKGTEGLRLWQEEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQD-------LREVME 192
M+ + +L QE Q + LSE S Q +RF E ++ K + FQD LRE +
Sbjct: 2480 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2539
Query: 193 KSSREALGHQEKLKAE------HRHRAKI-LNLKLREAEQQRVKQAEQERLRKEEGQIRL 245
+ ++ +++L A +H A+ + K E +Q ++ +QE L EE Q RL
Sbjct: 2540 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RL 2598
Query: 246 RALYALQEEMLQLSQQLDASEQHKALL-------KVDLAAFQTRGNQLCSLISGIIRASS 298
R E LQL + EQH+A L +AA +T N +L A
Sbjct: 2599 R-------EQLQLLE-----EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2646
Query: 299 ESSYPTAESQAEAERALREMRDL----LMNLGQEITRACEDKRRQD 340
E S+ + A+R L+E L L L Q T E RR+D
Sbjct: 2647 EHSFDGLRRKVSAQR-LQEAGILSAEELQRLAQGHTTVDELARRED 2691
Score = 40.8 bits (94), Expect = 0.004
Identities = 50/234 (21%), Positives = 104/234 (44%), Gaps = 20/234 (8%)
Query: 153 EQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHR 212
E ER ++EM+ Q + ++ + ++ E E+ EK R L QEK+
Sbjct: 2385 EAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHRTELATQEKVTL----- 2434
Query: 213 AKILNLKLREAEQ--QRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKA 270
+ L ++ ++++ +R+++A E R++E + L L+ E +Q QQ ++ +A
Sbjct: 2435 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2494
Query: 271 LLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEIT 330
L + +F + + L I + ++ + A+A++ E + + QE
Sbjct: 2495 LQQ----SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2550
Query: 331 RAC----EDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQV 380
R E +RRQ E E V+ ++ ++QQ + ++ + E LQ+
Sbjct: 2551 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2604
Score = 40.4 bits (93), Expect = 0.006
Identities = 65/286 (22%), Positives = 116/286 (40%), Gaps = 29/286 (10%)
Query: 152 EEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
EE+ R S+ E + RF E E E LR + E++ R+ +E +
Sbjct: 1779 EEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRA 1833
Query: 211 HRAKILNLKLRE-AEQQRVKQAEQERLRKEEGQI-RLRALYALQEEMLQLSQQLDASEQH 268
++L KL E R+K + L+++E + RLR L ++E Q + + + QH
Sbjct: 1834 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL--AEDEAFQRRRLEEQAAQH 1891
Query: 269 KALLKVDLAAFQTRGNQLCSLISGIIR--------------ASSESSYPTAESQAEAERA 314
KA ++ LA + + G++ A S A +AE E
Sbjct: 1892 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1951
Query: 315 LREMR----DLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGP 370
L +R D L + Q A ++ EEE + + E ++Q+ A +E A +
Sbjct: 1952 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE-AARQRKA 2010
Query: 371 GGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAK 416
++ E L+ KV++ + Q+++ Q L E ++ K
Sbjct: 2011 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2056
Score = 39.3 bits (90), Expect = 0.012
Identities = 62/307 (20%), Positives = 141/307 (45%), Gaps = 28/307 (9%)
Query: 110 DESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQER-KVQALSEMASEQ 168
+E+ H ++++ + + +K E + + +R+ EE + K + +E +
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2259
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLK---------AEHRHRA-KILNL 218
L+ D + Q +E + +++V E+++R ++ QE + A+ R A K+L
Sbjct: 2260 LRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2318
Query: 219 KLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAA 278
K++ ++ +AE E L++++ ++ LQE+ Q++QQL Q + L A
Sbjct: 2319 KMQAVQEATRLKAEAELLQQQK-ELAQEQARRLQEDKEQMAQQLAEETQG---FQRTLEA 2374
Query: 279 FQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQ---------EI 329
+ R ++ + + +E S A ++ +A+R ++ ++ L + +
Sbjct: 2375 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2434
Query: 330 TRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQW 389
+ E +R+Q + +A+ +L+EA + E KE ++E++Q Q+ +Q
Sbjct: 2435 VQTLEIQRQQSDHDAE-RLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2491
Query: 390 YQQLQDA 396
Q LQ +
Sbjct: 2492 TQALQQS 2498
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 10/188 (5%)
Query: 145 EGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEK 204
E LR E ER+ + L + A + +E + ++Q + Q+ + + + E ++
Sbjct: 2450 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2509
Query: 205 LKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEE---------- 254
+ + +AK+ L E + + + EQ+R +++ Q R R + +++E
Sbjct: 2510 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2569
Query: 255 MLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERA 314
+ + ++L EQ + + LA R + L+ RA+ S SQ A +
Sbjct: 2570 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2629
Query: 315 LREMRDLL 322
L RD L
Sbjct: 2630 LPNGRDAL 2637
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 55.8 bits (133), Expect = 1e-07
Identities = 63/230 (27%), Positives = 107/230 (46%), Gaps = 28/230 (12%)
Query: 151 QEEQERKVQ--ALSEMASEQLKRFDEWKELKQHKEFQ---DLREVMEKSS---REALGHQ 202
+EE ER+ Q A +E A E+ +R E +LK ++ + EV ++ S EA +
Sbjct: 1607 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 203 EKLKAEHRHRAKILNLKLRE---AEQQRVKQAE------QERLRKEEGQIRLRA------ 247
E+ + E R R K +R+ AEQ+ KQ + Q+RL E+ IRLRA
Sbjct: 1667 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 248 --LYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTA 305
L+EE+ +L ++ A+ Q + L+ +LA + ++ L++ RA ES +
Sbjct: 1727 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1783
Query: 306 ESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQ 355
+S+ E R+L + A E KR++ E Q A+ ++
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1833
Score = 50.1 bits (118), Expect = 7e-06
Identities = 62/272 (22%), Positives = 114/272 (41%), Gaps = 17/272 (6%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
+E R E EL+ ++ Q L E+ REA +K A A+ L E E+
Sbjct: 1955 AEDTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2013
Query: 226 QRVKQAEQERLRKEEGQIRLRALYALQE---EMLQLSQQLD--ASEQHKALLKVDLAAFQ 280
+ K E RLR+ Q R L QE + LQ ++ A +Q + L+ L Q
Sbjct: 2014 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2073
Query: 281 TRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDK---R 337
+ +QL RA+ E+ +++ EA ++ R++ + + + ++ E++ R
Sbjct: 2074 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-----AERLKQSAEEQAQAR 2128
Query: 338 RQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDAS 397
Q + A+ +EA+ + A E A Q + K + T++ Q++
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188
Query: 398 MQCVLTFEGLTNSK---DSQAKKIKMDLQKAA 426
L E + K D + +++K + +AA
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2220
Score = 48.1 bits (113), Expect = 3e-05
Identities = 52/221 (23%), Positives = 97/221 (43%), Gaps = 19/221 (8%)
Query: 151 QEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
Q+E +RK QA E+AS E + +E Q + +E+ +A + +L+
Sbjct: 1504 QDESQRKRQAEVELASRVKA------EAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1557
Query: 211 HRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLR--------ALYALQEEMLQLSQQL 262
RA+ + + L A++ + + +R E +L A+ L+EE + +QQ
Sbjct: 1558 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1617
Query: 263 DASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLL 322
+E+ + + +L +Q + N+ L + + S AE++ + E A RE R
Sbjct: 1618 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR--- 1674
Query: 323 MNLGQEITRACEDKRRQDEE-EAQVKLQEAQMQQGPEAHKE 362
G+ +A + ++E E Q +L E QQ A +E
Sbjct: 1675 -RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Score = 46.6 bits (109), Expect = 8e-05
Identities = 50/241 (20%), Positives = 107/241 (44%), Gaps = 41/241 (17%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
E + RM+ E L Q +ER+ A E A E+ ++ E + + ++ +E+ ++
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1398
Query: 196 REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRL--RALYALQE 253
E + +E + + I + E Q+++Q+ + ++ + Q R+ ++E
Sbjct: 1399 EEVVRREEAAVDAQQQKRSI------QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1452
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
E+ + QL+A+E+ + + +L A + R + E+ ++Q EAER
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALRAR--------------AEEAEAQKRQAQEEAER 1498
Query: 314 ALREMRD-----------LLMNLGQEITRACEDKR--------RQDEEEAQVKLQEAQMQ 354
R+++D L + E A E +R R EEA+ +L++A+++
Sbjct: 1499 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1558
Query: 355 Q 355
+
Sbjct: 1559 R 1559
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/282 (22%), Positives = 126/282 (44%), Gaps = 15/282 (5%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
SE L+R +E + L + + ++ + E + AL Q +L H + +E +Q
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERERLAEVEA--ALEKQRQLAEAHAQAKAQAEREAKELQQ 1395
Query: 226 QRVKQAEQERLRKEEGQIRLRALY-ALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGN 284
+ ++E +R+EE + + ++QEE+ QL Q +A Q KA + R
Sbjct: 1396 RM----QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1451
Query: 285 QLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEA 344
+ ++ + A +E AE + +A RA E + QE E RRQ ++E+
Sbjct: 1452 EEIRVVRLQLEA-TERQRGGAEGELQALRARAEEAEAQKRQAQE---EAERLRRQVQDES 1507
Query: 345 QVKLQEAQMQQGPEAHKEPPAPSQGPGGKQN-EDLQVKVQDITMQWYQQLQDASMQCVLT 403
Q K ++A+++ E A + Q E+L+++ ++ + Q + + Q +
Sbjct: 1508 QRK-RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 404 FEGLTNSKDSQAKKIKMDL-QKAATIPVS-QISTIAGSKLKE 443
E S +++ + + +K A + S Q +A ++L+E
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1608
Score = 44.7 bits (104), Expect = 3e-04
Identities = 60/255 (23%), Positives = 103/255 (40%), Gaps = 18/255 (7%)
Query: 109 KDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQ 168
+DESQ ++ + +K E E ++ E LRL EE ER+++ + Q
Sbjct: 1504 QDESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQ 1562
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRV 228
++ E + E Q R + + + + L+ EH A++ R A+QQ
Sbjct: 1563 VQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERRAQQQ-- 1617
Query: 229 KQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCS 288
AE ER R EE + L E L+L Q + Q K+L + + A Q + +
Sbjct: 1618 --AEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE-AEKQKEEAEREA 1673
Query: 289 LISGIIRASSESSYPTAESQAEAERALRE--------MRDLLMNLGQEITRACEDKRRQD 340
G + AE + E +R L E L+ L E + + ++ +
Sbjct: 1674 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733
Query: 341 EEEAQVKLQEAQMQQ 355
EE A+++ + A Q
Sbjct: 1734 EELARLQREAAAATQ 1748
Score = 42.4 bits (98), Expect = 0.001
Identities = 66/226 (29%), Positives = 98/226 (43%), Gaps = 40/226 (17%)
Query: 141 MKGTEGLRLWQEEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQD-------LREVME 192
M+ + +L QE Q + LSE S Q +RF E ++ K + FQD LRE +
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535
Query: 193 KSSREALGHQEKLKAE------HRHRAKI-LNLKLREAEQQRVKQAEQERLRKEEGQIRL 245
+ ++ +++L A +H A+ + K E +Q ++ +QE L EE Q RL
Sbjct: 2536 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RL 2594
Query: 246 RALYALQEEMLQLSQQLDASEQHKALL-------KVDLAAFQTRGNQLCSLISGIIRASS 298
R E LQL + EQH+A L +AA +T N +L A
Sbjct: 2595 R-------EQLQLLE-----EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2642
Query: 299 ESSYPTAESQAEAERALREMRDL----LMNLGQEITRACEDKRRQD 340
E S+ + A+R L+E L L L Q T E RR+D
Sbjct: 2643 EHSFDGLRRKVSAQR-LQEAGILSAEELQRLAQGHTTVDELARRED 2687
Score = 40.8 bits (94), Expect = 0.004
Identities = 50/234 (21%), Positives = 104/234 (44%), Gaps = 20/234 (8%)
Query: 153 EQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHR 212
E ER ++EM+ Q + ++ + ++ E E+ EK R L QEK+
Sbjct: 2381 EAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHRTELATQEKVTL----- 2430
Query: 213 AKILNLKLREAEQ--QRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKA 270
+ L ++ ++++ +R+++A E R++E + L L+ E +Q QQ ++ +A
Sbjct: 2431 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2490
Query: 271 LLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEIT 330
L + +F + + L I + ++ + A+A++ E + + QE
Sbjct: 2491 LQQ----SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2546
Query: 331 RAC----EDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQV 380
R E +RRQ E E V+ ++ ++QQ + ++ + E LQ+
Sbjct: 2547 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2600
Score = 40.4 bits (93), Expect = 0.006
Identities = 65/286 (22%), Positives = 116/286 (40%), Gaps = 29/286 (10%)
Query: 152 EEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
EE+ R S+ E + RF E E E LR + E++ R+ +E +
Sbjct: 1775 EEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRA 1829
Query: 211 HRAKILNLKLRE-AEQQRVKQAEQERLRKEEGQI-RLRALYALQEEMLQLSQQLDASEQH 268
++L KL E R+K + L+++E + RLR L ++E Q + + + QH
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL--AEDEAFQRRRLEEQAAQH 1887
Query: 269 KALLKVDLAAFQTRGNQLCSLISGIIR--------------ASSESSYPTAESQAEAERA 314
KA ++ LA + + G++ A S A +AE E
Sbjct: 1888 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1947
Query: 315 LREMR----DLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGP 370
L +R D L + Q A ++ EEE + + E ++Q+ A +E A +
Sbjct: 1948 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE-AARQRKA 2006
Query: 371 GGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAK 416
++ E L+ KV++ + Q+++ Q L E ++ K
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2052
Score = 39.3 bits (90), Expect = 0.012
Identities = 62/307 (20%), Positives = 141/307 (45%), Gaps = 28/307 (9%)
Query: 110 DESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQER-KVQALSEMASEQ 168
+E+ H ++++ + + +K E + + +R+ EE + K + +E +
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLK---------AEHRHRA-KILNL 218
L+ D + Q +E + +++V E+++R ++ QE + A+ R A K+L
Sbjct: 2256 LRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Query: 219 KLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAA 278
K++ ++ +AE E L++++ ++ LQE+ Q++QQL Q + L A
Sbjct: 2315 KMQAVQEATRLKAEAELLQQQK-ELAQEQARRLQEDKEQMAQQLAEETQG---FQRTLEA 2370
Query: 279 FQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQ---------EI 329
+ R ++ + + +E S A ++ +A+R ++ ++ L + +
Sbjct: 2371 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2430
Query: 330 TRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQW 389
+ E +R+Q + +A+ +L+EA + E KE ++E++Q Q+ +Q
Sbjct: 2431 VQTLEIQRQQSDHDAE-RLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2487
Query: 390 YQQLQDA 396
Q LQ +
Sbjct: 2488 TQALQQS 2494
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 10/188 (5%)
Query: 145 EGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEK 204
E LR E ER+ + L + A + +E + ++Q + Q+ + + + E ++
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 205 LKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEE---------- 254
+ + +AK+ L E + + + EQ+R +++ Q R R + +++E
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565
Query: 255 MLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERA 314
+ + ++L EQ + + LA R + L+ RA+ S SQ A +
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2625
Query: 315 LREMRDLL 322
L RD L
Sbjct: 2626 LPNGRDAL 2633
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 55.8 bits (133), Expect = 1e-07
Identities = 63/230 (27%), Positives = 107/230 (46%), Gaps = 28/230 (12%)
Query: 151 QEEQERKVQ--ALSEMASEQLKRFDEWKELKQHKEFQ---DLREVMEKSS---REALGHQ 202
+EE ER+ Q A +E A E+ +R E +LK ++ + EV ++ S EA +
Sbjct: 1575 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1634
Query: 203 EKLKAEHRHRAKILNLKLRE---AEQQRVKQAE------QERLRKEEGQIRLRA------ 247
E+ + E R R K +R+ AEQ+ KQ + Q+RL E+ IRLRA
Sbjct: 1635 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694
Query: 248 --LYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTA 305
L+EE+ +L ++ A+ Q + L+ +LA + ++ L++ RA ES +
Sbjct: 1695 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1751
Query: 306 ESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQ 355
+S+ E R+L + A E KR++ E Q A+ ++
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1801
Score = 50.1 bits (118), Expect = 7e-06
Identities = 62/272 (22%), Positives = 114/272 (41%), Gaps = 17/272 (6%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
+E R E EL+ ++ Q L E+ REA +K A A+ L E E+
Sbjct: 1923 AEDTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1981
Query: 226 QRVKQAEQERLRKEEGQIRLRALYALQE---EMLQLSQQLD--ASEQHKALLKVDLAAFQ 280
+ K E RLR+ Q R L QE + LQ ++ A +Q + L+ L Q
Sbjct: 1982 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2041
Query: 281 TRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDK---R 337
+ +QL RA+ E+ +++ EA ++ R++ + + + ++ E++ R
Sbjct: 2042 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-----AERLKQSAEEQAQAR 2096
Query: 338 RQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDAS 397
Q + A+ +EA+ + A E A Q + K + T++ Q++
Sbjct: 2097 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2156
Query: 398 MQCVLTFEGLTNSK---DSQAKKIKMDLQKAA 426
L E + K D + +++K + +AA
Sbjct: 2157 TTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2188
Score = 48.1 bits (113), Expect = 3e-05
Identities = 52/221 (23%), Positives = 97/221 (43%), Gaps = 19/221 (8%)
Query: 151 QEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
Q+E +RK QA E+AS E + +E Q + +E+ +A + +L+
Sbjct: 1472 QDESQRKRQAEVELASRVKA------EAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1525
Query: 211 HRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLR--------ALYALQEEMLQLSQQL 262
RA+ + + L A++ + + +R E +L A+ L+EE + +QQ
Sbjct: 1526 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1585
Query: 263 DASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLL 322
+E+ + + +L +Q + N+ L + + S AE++ + E A RE R
Sbjct: 1586 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR--- 1642
Query: 323 MNLGQEITRACEDKRRQDEE-EAQVKLQEAQMQQGPEAHKE 362
G+ +A + ++E E Q +L E QQ A +E
Sbjct: 1643 -RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682
Score = 46.6 bits (109), Expect = 8e-05
Identities = 50/241 (20%), Positives = 107/241 (44%), Gaps = 41/241 (17%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
E + RM+ E L Q +ER+ A E A E+ ++ E + + ++ +E+ ++
Sbjct: 1307 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1366
Query: 196 REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRL--RALYALQE 253
E + +E + + I + E Q+++Q+ + ++ + Q R+ ++E
Sbjct: 1367 EEVVRREEAAVDAQQQKRSI------QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1420
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
E+ + QL+A+E+ + + +L A + R + E+ ++Q EAER
Sbjct: 1421 EIRVVRLQLEATERQRGGAEGELQALRAR--------------AEEAEAQKRQAQEEAER 1466
Query: 314 ALREMRD-----------LLMNLGQEITRACEDKR--------RQDEEEAQVKLQEAQMQ 354
R+++D L + E A E +R R EEA+ +L++A+++
Sbjct: 1467 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1526
Query: 355 Q 355
+
Sbjct: 1527 R 1527
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/282 (22%), Positives = 126/282 (44%), Gaps = 15/282 (5%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
SE L+R +E + L + + ++ + E + AL Q +L H + +E +Q
Sbjct: 1306 SETLRRMEEEERLAEQQRAEERERLAEVEA--ALEKQRQLAEAHAQAKAQAEREAKELQQ 1363
Query: 226 QRVKQAEQERLRKEEGQIRLRALY-ALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGN 284
+ ++E +R+EE + + ++QEE+ QL Q +A Q KA + R
Sbjct: 1364 RM----QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1419
Query: 285 QLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEA 344
+ ++ + A +E AE + +A RA E + QE E RRQ ++E+
Sbjct: 1420 EEIRVVRLQLEA-TERQRGGAEGELQALRARAEEAEAQKRQAQE---EAERLRRQVQDES 1475
Query: 345 QVKLQEAQMQQGPEAHKEPPAPSQGPGGKQN-EDLQVKVQDITMQWYQQLQDASMQCVLT 403
Q K ++A+++ E A + Q E+L+++ ++ + Q + + Q +
Sbjct: 1476 QRK-RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1534
Query: 404 FEGLTNSKDSQAKKIKMDL-QKAATIPVS-QISTIAGSKLKE 443
E S +++ + + +K A + S Q +A ++L+E
Sbjct: 1535 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1576
Score = 44.7 bits (104), Expect = 3e-04
Identities = 60/255 (23%), Positives = 103/255 (40%), Gaps = 18/255 (7%)
Query: 109 KDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQ 168
+DESQ ++ + +K E E ++ E LRL EE ER+++ + Q
Sbjct: 1472 QDESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQ 1530
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRV 228
++ E + E Q R + + + + L+ EH A++ R A+QQ
Sbjct: 1531 VQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERRAQQQ-- 1585
Query: 229 KQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCS 288
AE ER R EE + L E L+L Q + Q K+L + + A Q + +
Sbjct: 1586 --AEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE-AEKQKEEAEREA 1641
Query: 289 LISGIIRASSESSYPTAESQAEAERALRE--------MRDLLMNLGQEITRACEDKRRQD 340
G + AE + E +R L E L+ L E + + ++ +
Sbjct: 1642 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1701
Query: 341 EEEAQVKLQEAQMQQ 355
EE A+++ + A Q
Sbjct: 1702 EELARLQREAAAATQ 1716
Score = 42.4 bits (98), Expect = 0.001
Identities = 66/226 (29%), Positives = 98/226 (43%), Gaps = 40/226 (17%)
Query: 141 MKGTEGLRLWQEEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQD-------LREVME 192
M+ + +L QE Q + LSE S Q +RF E ++ K + FQD LRE +
Sbjct: 2444 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2503
Query: 193 KSSREALGHQEKLKAE------HRHRAKI-LNLKLREAEQQRVKQAEQERLRKEEGQIRL 245
+ ++ +++L A +H A+ + K E +Q ++ +QE L EE Q RL
Sbjct: 2504 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RL 2562
Query: 246 RALYALQEEMLQLSQQLDASEQHKALL-------KVDLAAFQTRGNQLCSLISGIIRASS 298
R E LQL + EQH+A L +AA +T N +L A
Sbjct: 2563 R-------EQLQLLE-----EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2610
Query: 299 ESSYPTAESQAEAERALREMRDL----LMNLGQEITRACEDKRRQD 340
E S+ + A+R L+E L L L Q T E RR+D
Sbjct: 2611 EHSFDGLRRKVSAQR-LQEAGILSAEELQRLAQGHTTVDELARRED 2655
Score = 40.8 bits (94), Expect = 0.004
Identities = 50/234 (21%), Positives = 104/234 (44%), Gaps = 20/234 (8%)
Query: 153 EQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHR 212
E ER ++EM+ Q + ++ + ++ E E+ EK R L QEK+
Sbjct: 2349 EAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHRTELATQEKVTL----- 2398
Query: 213 AKILNLKLREAEQ--QRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKA 270
+ L ++ ++++ +R+++A E R++E + L L+ E +Q QQ ++ +A
Sbjct: 2399 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2458
Query: 271 LLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEIT 330
L + +F + + L I + ++ + A+A++ E + + QE
Sbjct: 2459 LQQ----SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2514
Query: 331 RAC----EDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQV 380
R E +RRQ E E V+ ++ ++QQ + ++ + E LQ+
Sbjct: 2515 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2568
Score = 40.4 bits (93), Expect = 0.006
Identities = 65/286 (22%), Positives = 116/286 (40%), Gaps = 29/286 (10%)
Query: 152 EEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
EE+ R S+ E + RF E E E LR + E++ R+ +E +
Sbjct: 1743 EEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRA 1797
Query: 211 HRAKILNLKLRE-AEQQRVKQAEQERLRKEEGQI-RLRALYALQEEMLQLSQQLDASEQH 268
++L KL E R+K + L+++E + RLR L ++E Q + + + QH
Sbjct: 1798 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL--AEDEAFQRRRLEEQAAQH 1855
Query: 269 KALLKVDLAAFQTRGNQLCSLISGIIR--------------ASSESSYPTAESQAEAERA 314
KA ++ LA + + G++ A S A +AE E
Sbjct: 1856 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1915
Query: 315 LREMR----DLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGP 370
L +R D L + Q A ++ EEE + + E ++Q+ A +E A +
Sbjct: 1916 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE-AARQRKA 1974
Query: 371 GGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAK 416
++ E L+ KV++ + Q+++ Q L E ++ K
Sbjct: 1975 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2020
Score = 39.3 bits (90), Expect = 0.012
Identities = 62/307 (20%), Positives = 141/307 (45%), Gaps = 28/307 (9%)
Query: 110 DESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQER-KVQALSEMASEQ 168
+E+ H ++++ + + +K E + + +R+ EE + K + +E +
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2223
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLK---------AEHRHRA-KILNL 218
L+ D + Q +E + +++V E+++R ++ QE + A+ R A K+L
Sbjct: 2224 LRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2282
Query: 219 KLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAA 278
K++ ++ +AE E L++++ ++ LQE+ Q++QQL Q + L A
Sbjct: 2283 KMQAVQEATRLKAEAELLQQQK-ELAQEQARRLQEDKEQMAQQLAEETQG---FQRTLEA 2338
Query: 279 FQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQ---------EI 329
+ R ++ + + +E S A ++ +A+R ++ ++ L + +
Sbjct: 2339 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2398
Query: 330 TRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQW 389
+ E +R+Q + +A+ +L+EA + E KE ++E++Q Q+ +Q
Sbjct: 2399 VQTLEIQRQQSDHDAE-RLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2455
Query: 390 YQQLQDA 396
Q LQ +
Sbjct: 2456 TQALQQS 2462
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 10/188 (5%)
Query: 145 EGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEK 204
E LR E ER+ + L + A + +E + ++Q + Q+ + + + E ++
Sbjct: 2414 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2473
Query: 205 LKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEE---------- 254
+ + +AK+ L E + + + EQ+R +++ Q R R + +++E
Sbjct: 2474 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2533
Query: 255 MLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERA 314
+ + ++L EQ + + LA R + L+ RA+ S SQ A +
Sbjct: 2534 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2593
Query: 315 LREMRDLL 322
L RD L
Sbjct: 2594 LPNGRDAL 2601
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 55.8 bits (133), Expect = 1e-07
Identities = 63/230 (27%), Positives = 107/230 (46%), Gaps = 28/230 (12%)
Query: 151 QEEQERKVQ--ALSEMASEQLKRFDEWKELKQHKEFQ---DLREVMEKSS---REALGHQ 202
+EE ER+ Q A +E A E+ +R E +LK ++ + EV ++ S EA +
Sbjct: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803
Query: 203 EKLKAEHRHRAKILNLKLRE---AEQQRVKQAE------QERLRKEEGQIRLRA------ 247
E+ + E R R K +R+ AEQ+ KQ + Q+RL E+ IRLRA
Sbjct: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863
Query: 248 --LYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTA 305
L+EE+ +L ++ A+ Q + L+ +LA + ++ L++ RA ES +
Sbjct: 1864 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1920
Query: 306 ESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQ 355
+S+ E R+L + A E KR++ E Q A+ ++
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1970
Score = 50.1 bits (118), Expect = 7e-06
Identities = 62/272 (22%), Positives = 114/272 (41%), Gaps = 17/272 (6%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
+E R E EL+ ++ Q L E+ REA +K A A+ L E E+
Sbjct: 2092 AEDTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150
Query: 226 QRVKQAEQERLRKEEGQIRLRALYALQE---EMLQLSQQLD--ASEQHKALLKVDLAAFQ 280
+ K E RLR+ Q R L QE + LQ ++ A +Q + L+ L Q
Sbjct: 2151 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2210
Query: 281 TRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDK---R 337
+ +QL RA+ E+ +++ EA ++ R++ + + + ++ E++ R
Sbjct: 2211 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-----AERLKQSAEEQAQAR 2265
Query: 338 RQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDAS 397
Q + A+ +EA+ + A E A Q + K + T++ Q++
Sbjct: 2266 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2325
Query: 398 MQCVLTFEGLTNSK---DSQAKKIKMDLQKAA 426
L E + K D + +++K + +AA
Sbjct: 2326 TTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2357
Score = 48.1 bits (113), Expect = 3e-05
Identities = 52/221 (23%), Positives = 97/221 (43%), Gaps = 19/221 (8%)
Query: 151 QEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
Q+E +RK QA E+AS E + +E Q + +E+ +A + +L+
Sbjct: 1641 QDESQRKRQAEVELASRVKA------EAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1694
Query: 211 HRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLR--------ALYALQEEMLQLSQQL 262
RA+ + + L A++ + + +R E +L A+ L+EE + +QQ
Sbjct: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1754
Query: 263 DASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLL 322
+E+ + + +L +Q + N+ L + + S AE++ + E A RE R
Sbjct: 1755 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR--- 1811
Query: 323 MNLGQEITRACEDKRRQDEE-EAQVKLQEAQMQQGPEAHKE 362
G+ +A + ++E E Q +L E QQ A +E
Sbjct: 1812 -RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851
Score = 46.6 bits (109), Expect = 8e-05
Identities = 50/241 (20%), Positives = 107/241 (44%), Gaps = 41/241 (17%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
E + RM+ E L Q +ER+ A E A E+ ++ E + + ++ +E+ ++
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1535
Query: 196 REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRL--RALYALQE 253
E + +E + + I + E Q+++Q+ + ++ + Q R+ ++E
Sbjct: 1536 EEVVRREEAAVDAQQQKRSI------QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1589
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
E+ + QL+A+E+ + + +L A + R + E+ ++Q EAER
Sbjct: 1590 EIRVVRLQLEATERQRGGAEGELQALRAR--------------AEEAEAQKRQAQEEAER 1635
Query: 314 ALREMRD-----------LLMNLGQEITRACEDKR--------RQDEEEAQVKLQEAQMQ 354
R+++D L + E A E +R R EEA+ +L++A+++
Sbjct: 1636 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1695
Query: 355 Q 355
+
Sbjct: 1696 R 1696
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/282 (22%), Positives = 126/282 (44%), Gaps = 15/282 (5%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
SE L+R +E + L + + ++ + E + AL Q +L H + +E +Q
Sbjct: 1475 SETLRRMEEEERLAEQQRAEERERLAEVEA--ALEKQRQLAEAHAQAKAQAEREAKELQQ 1532
Query: 226 QRVKQAEQERLRKEEGQIRLRALY-ALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGN 284
+ ++E +R+EE + + ++QEE+ QL Q +A Q KA + R
Sbjct: 1533 RM----QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1588
Query: 285 QLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEA 344
+ ++ + A +E AE + +A RA E + QE E RRQ ++E+
Sbjct: 1589 EEIRVVRLQLEA-TERQRGGAEGELQALRARAEEAEAQKRQAQE---EAERLRRQVQDES 1644
Query: 345 QVKLQEAQMQQGPEAHKEPPAPSQGPGGKQN-EDLQVKVQDITMQWYQQLQDASMQCVLT 403
Q K ++A+++ E A + Q E+L+++ ++ + Q + + Q +
Sbjct: 1645 QRK-RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1703
Query: 404 FEGLTNSKDSQAKKIKMDL-QKAATIPVS-QISTIAGSKLKE 443
E S +++ + + +K A + S Q +A ++L+E
Sbjct: 1704 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1745
Score = 44.7 bits (104), Expect = 3e-04
Identities = 60/255 (23%), Positives = 103/255 (40%), Gaps = 18/255 (7%)
Query: 109 KDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQ 168
+DESQ ++ + +K E E ++ E LRL EE ER+++ + Q
Sbjct: 1641 QDESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQ 1699
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRV 228
++ E + E Q R + + + + L+ EH A++ R A+QQ
Sbjct: 1700 VQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERRAQQQ-- 1754
Query: 229 KQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCS 288
AE ER R EE + L E L+L Q + Q K+L + + A Q + +
Sbjct: 1755 --AEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE-AEKQKEEAEREA 1810
Query: 289 LISGIIRASSESSYPTAESQAEAERALRE--------MRDLLMNLGQEITRACEDKRRQD 340
G + AE + E +R L E L+ L E + + ++ +
Sbjct: 1811 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1870
Query: 341 EEEAQVKLQEAQMQQ 355
EE A+++ + A Q
Sbjct: 1871 EELARLQREAAAATQ 1885
Score = 42.4 bits (98), Expect = 0.001
Identities = 66/226 (29%), Positives = 98/226 (43%), Gaps = 40/226 (17%)
Query: 141 MKGTEGLRLWQEEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQD-------LREVME 192
M+ + +L QE Q + LSE S Q +RF E ++ K + FQD LRE +
Sbjct: 2613 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2672
Query: 193 KSSREALGHQEKLKAE------HRHRAKI-LNLKLREAEQQRVKQAEQERLRKEEGQIRL 245
+ ++ +++L A +H A+ + K E +Q ++ +QE L EE Q RL
Sbjct: 2673 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RL 2731
Query: 246 RALYALQEEMLQLSQQLDASEQHKALL-------KVDLAAFQTRGNQLCSLISGIIRASS 298
R E LQL + EQH+A L +AA +T N +L A
Sbjct: 2732 R-------EQLQLLE-----EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2779
Query: 299 ESSYPTAESQAEAERALREMRDL----LMNLGQEITRACEDKRRQD 340
E S+ + A+R L+E L L L Q T E RR+D
Sbjct: 2780 EHSFDGLRRKVSAQR-LQEAGILSAEELQRLAQGHTTVDELARRED 2824
Score = 40.8 bits (94), Expect = 0.004
Identities = 50/234 (21%), Positives = 104/234 (44%), Gaps = 20/234 (8%)
Query: 153 EQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHR 212
E ER ++EM+ Q + ++ + ++ E E+ EK R L QEK+
Sbjct: 2518 EAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHRTELATQEKVTL----- 2567
Query: 213 AKILNLKLREAEQ--QRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKA 270
+ L ++ ++++ +R+++A E R++E + L L+ E +Q QQ ++ +A
Sbjct: 2568 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2627
Query: 271 LLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEIT 330
L + +F + + L I + ++ + A+A++ E + + QE
Sbjct: 2628 LQQ----SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2683
Query: 331 RAC----EDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQV 380
R E +RRQ E E V+ ++ ++QQ + ++ + E LQ+
Sbjct: 2684 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2737
Score = 40.4 bits (93), Expect = 0.006
Identities = 65/286 (22%), Positives = 116/286 (40%), Gaps = 29/286 (10%)
Query: 152 EEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
EE+ R S+ E + RF E E E LR + E++ R+ +E +
Sbjct: 1912 EEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRA 1966
Query: 211 HRAKILNLKLRE-AEQQRVKQAEQERLRKEEGQI-RLRALYALQEEMLQLSQQLDASEQH 268
++L KL E R+K + L+++E + RLR L ++E Q + + + QH
Sbjct: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL--AEDEAFQRRRLEEQAAQH 2024
Query: 269 KALLKVDLAAFQTRGNQLCSLISGIIR--------------ASSESSYPTAESQAEAERA 314
KA ++ LA + + G++ A S A +AE E
Sbjct: 2025 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 2084
Query: 315 LREMR----DLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGP 370
L +R D L + Q A ++ EEE + + E ++Q+ A +E A +
Sbjct: 2085 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE-AARQRKA 2143
Query: 371 GGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAK 416
++ E L+ KV++ + Q+++ Q L E ++ K
Sbjct: 2144 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2189
Score = 39.3 bits (90), Expect = 0.012
Identities = 62/307 (20%), Positives = 141/307 (45%), Gaps = 28/307 (9%)
Query: 110 DESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQER-KVQALSEMASEQ 168
+E+ H ++++ + + +K E + + +R+ EE + K + +E +
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2392
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLK---------AEHRHRA-KILNL 218
L+ D + Q +E + +++V E+++R ++ QE + A+ R A K+L
Sbjct: 2393 LRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2451
Query: 219 KLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAA 278
K++ ++ +AE E L++++ ++ LQE+ Q++QQL Q + L A
Sbjct: 2452 KMQAVQEATRLKAEAELLQQQK-ELAQEQARRLQEDKEQMAQQLAEETQG---FQRTLEA 2507
Query: 279 FQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQ---------EI 329
+ R ++ + + +E S A ++ +A+R ++ ++ L + +
Sbjct: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2567
Query: 330 TRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQW 389
+ E +R+Q + +A+ +L+EA + E KE ++E++Q Q+ +Q
Sbjct: 2568 VQTLEIQRQQSDHDAE-RLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2624
Query: 390 YQQLQDA 396
Q LQ +
Sbjct: 2625 TQALQQS 2631
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 10/188 (5%)
Query: 145 EGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEK 204
E LR E ER+ + L + A + +E + ++Q + Q+ + + + E ++
Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2642
Query: 205 LKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEE---------- 254
+ + +AK+ L E + + + EQ+R +++ Q R R + +++E
Sbjct: 2643 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2702
Query: 255 MLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERA 314
+ + ++L EQ + + LA R + L+ RA+ S SQ A +
Sbjct: 2703 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2762
Query: 315 LREMRDLL 322
L RD L
Sbjct: 2763 LPNGRDAL 2770
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 55.8 bits (133), Expect = 1e-07
Identities = 63/230 (27%), Positives = 107/230 (46%), Gaps = 28/230 (12%)
Query: 151 QEEQERKVQ--ALSEMASEQLKRFDEWKELKQHKEFQ---DLREVMEKSS---REALGHQ 202
+EE ER+ Q A +E A E+ +R E +LK ++ + EV ++ S EA +
Sbjct: 1585 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1644
Query: 203 EKLKAEHRHRAKILNLKLRE---AEQQRVKQAE------QERLRKEEGQIRLRA------ 247
E+ + E R R K +R+ AEQ+ KQ + Q+RL E+ IRLRA
Sbjct: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
Query: 248 --LYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTA 305
L+EE+ +L ++ A+ Q + L+ +LA + ++ L++ RA ES +
Sbjct: 1705 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1761
Query: 306 ESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQ 355
+S+ E R+L + A E KR++ E Q A+ ++
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1811
Score = 50.1 bits (118), Expect = 7e-06
Identities = 62/272 (22%), Positives = 114/272 (41%), Gaps = 17/272 (6%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
+E R E EL+ ++ Q L E+ REA +K A A+ L E E+
Sbjct: 1933 AEDTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
Query: 226 QRVKQAEQERLRKEEGQIRLRALYALQE---EMLQLSQQLD--ASEQHKALLKVDLAAFQ 280
+ K E RLR+ Q R L QE + LQ ++ A +Q + L+ L Q
Sbjct: 1992 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2051
Query: 281 TRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDK---R 337
+ +QL RA+ E+ +++ EA ++ R++ + + + ++ E++ R
Sbjct: 2052 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-----AERLKQSAEEQAQAR 2106
Query: 338 RQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDAS 397
Q + A+ +EA+ + A E A Q + K + T++ Q++
Sbjct: 2107 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2166
Query: 398 MQCVLTFEGLTNSK---DSQAKKIKMDLQKAA 426
L E + K D + +++K + +AA
Sbjct: 2167 TTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2198
Score = 48.1 bits (113), Expect = 3e-05
Identities = 52/221 (23%), Positives = 97/221 (43%), Gaps = 19/221 (8%)
Query: 151 QEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
Q+E +RK QA E+AS E + +E Q + +E+ +A + +L+
Sbjct: 1482 QDESQRKRQAEVELASRVKA------EAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1535
Query: 211 HRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLR--------ALYALQEEMLQLSQQL 262
RA+ + + L A++ + + +R E +L A+ L+EE + +QQ
Sbjct: 1536 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1595
Query: 263 DASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLL 322
+E+ + + +L +Q + N+ L + + S AE++ + E A RE R
Sbjct: 1596 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR--- 1652
Query: 323 MNLGQEITRACEDKRRQDEE-EAQVKLQEAQMQQGPEAHKE 362
G+ +A + ++E E Q +L E QQ A +E
Sbjct: 1653 -RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692
Score = 46.6 bits (109), Expect = 8e-05
Identities = 50/241 (20%), Positives = 107/241 (44%), Gaps = 41/241 (17%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
E + RM+ E L Q +ER+ A E A E+ ++ E + + ++ +E+ ++
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376
Query: 196 REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRL--RALYALQE 253
E + +E + + I + E Q+++Q+ + ++ + Q R+ ++E
Sbjct: 1377 EEVVRREEAAVDAQQQKRSI------QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1430
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
E+ + QL+A+E+ + + +L A + R + E+ ++Q EAER
Sbjct: 1431 EIRVVRLQLEATERQRGGAEGELQALRAR--------------AEEAEAQKRQAQEEAER 1476
Query: 314 ALREMRD-----------LLMNLGQEITRACEDKR--------RQDEEEAQVKLQEAQMQ 354
R+++D L + E A E +R R EEA+ +L++A+++
Sbjct: 1477 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1536
Query: 355 Q 355
+
Sbjct: 1537 R 1537
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/282 (22%), Positives = 126/282 (44%), Gaps = 15/282 (5%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
SE L+R +E + L + + ++ + E + AL Q +L H + +E +Q
Sbjct: 1316 SETLRRMEEEERLAEQQRAEERERLAEVEA--ALEKQRQLAEAHAQAKAQAEREAKELQQ 1373
Query: 226 QRVKQAEQERLRKEEGQIRLRALY-ALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGN 284
+ ++E +R+EE + + ++QEE+ QL Q +A Q KA + R
Sbjct: 1374 RM----QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1429
Query: 285 QLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEA 344
+ ++ + A +E AE + +A RA E + QE E RRQ ++E+
Sbjct: 1430 EEIRVVRLQLEA-TERQRGGAEGELQALRARAEEAEAQKRQAQE---EAERLRRQVQDES 1485
Query: 345 QVKLQEAQMQQGPEAHKEPPAPSQGPGGKQN-EDLQVKVQDITMQWYQQLQDASMQCVLT 403
Q K ++A+++ E A + Q E+L+++ ++ + Q + + Q +
Sbjct: 1486 QRK-RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1544
Query: 404 FEGLTNSKDSQAKKIKMDL-QKAATIPVS-QISTIAGSKLKE 443
E S +++ + + +K A + S Q +A ++L+E
Sbjct: 1545 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1586
Score = 44.7 bits (104), Expect = 3e-04
Identities = 60/255 (23%), Positives = 103/255 (40%), Gaps = 18/255 (7%)
Query: 109 KDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQ 168
+DESQ ++ + +K E E ++ E LRL EE ER+++ + Q
Sbjct: 1482 QDESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQ 1540
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRV 228
++ E + E Q R + + + + L+ EH A++ R A+QQ
Sbjct: 1541 VQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERRAQQQ-- 1595
Query: 229 KQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCS 288
AE ER R EE + L E L+L Q + Q K+L + + A Q + +
Sbjct: 1596 --AEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE-AEKQKEEAEREA 1651
Query: 289 LISGIIRASSESSYPTAESQAEAERALRE--------MRDLLMNLGQEITRACEDKRRQD 340
G + AE + E +R L E L+ L E + + ++ +
Sbjct: 1652 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1711
Query: 341 EEEAQVKLQEAQMQQ 355
EE A+++ + A Q
Sbjct: 1712 EELARLQREAAAATQ 1726
Score = 42.4 bits (98), Expect = 0.001
Identities = 66/226 (29%), Positives = 98/226 (43%), Gaps = 40/226 (17%)
Query: 141 MKGTEGLRLWQEEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQD-------LREVME 192
M+ + +L QE Q + LSE S Q +RF E ++ K + FQD LRE +
Sbjct: 2454 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2513
Query: 193 KSSREALGHQEKLKAE------HRHRAKI-LNLKLREAEQQRVKQAEQERLRKEEGQIRL 245
+ ++ +++L A +H A+ + K E +Q ++ +QE L EE Q RL
Sbjct: 2514 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RL 2572
Query: 246 RALYALQEEMLQLSQQLDASEQHKALL-------KVDLAAFQTRGNQLCSLISGIIRASS 298
R E LQL + EQH+A L +AA +T N +L A
Sbjct: 2573 R-------EQLQLLE-----EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2620
Query: 299 ESSYPTAESQAEAERALREMRDL----LMNLGQEITRACEDKRRQD 340
E S+ + A+R L+E L L L Q T E RR+D
Sbjct: 2621 EHSFDGLRRKVSAQR-LQEAGILSAEELQRLAQGHTTVDELARRED 2665
Score = 40.8 bits (94), Expect = 0.004
Identities = 50/234 (21%), Positives = 104/234 (44%), Gaps = 20/234 (8%)
Query: 153 EQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHR 212
E ER ++EM+ Q + ++ + ++ E E+ EK R L QEK+
Sbjct: 2359 EAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHRTELATQEKVTL----- 2408
Query: 213 AKILNLKLREAEQ--QRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKA 270
+ L ++ ++++ +R+++A E R++E + L L+ E +Q QQ ++ +A
Sbjct: 2409 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2468
Query: 271 LLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEIT 330
L + +F + + L I + ++ + A+A++ E + + QE
Sbjct: 2469 LQQ----SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2524
Query: 331 RAC----EDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQV 380
R E +RRQ E E V+ ++ ++QQ + ++ + E LQ+
Sbjct: 2525 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2578
Score = 40.4 bits (93), Expect = 0.006
Identities = 65/286 (22%), Positives = 116/286 (40%), Gaps = 29/286 (10%)
Query: 152 EEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
EE+ R S+ E + RF E E E LR + E++ R+ +E +
Sbjct: 1753 EEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRA 1807
Query: 211 HRAKILNLKLRE-AEQQRVKQAEQERLRKEEGQI-RLRALYALQEEMLQLSQQLDASEQH 268
++L KL E R+K + L+++E + RLR L ++E Q + + + QH
Sbjct: 1808 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL--AEDEAFQRRRLEEQAAQH 1865
Query: 269 KALLKVDLAAFQTRGNQLCSLISGIIR--------------ASSESSYPTAESQAEAERA 314
KA ++ LA + + G++ A S A +AE E
Sbjct: 1866 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1925
Query: 315 LREMR----DLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGP 370
L +R D L + Q A ++ EEE + + E ++Q+ A +E A +
Sbjct: 1926 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE-AARQRKA 1984
Query: 371 GGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAK 416
++ E L+ KV++ + Q+++ Q L E ++ K
Sbjct: 1985 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2030
Score = 39.3 bits (90), Expect = 0.012
Identities = 62/307 (20%), Positives = 141/307 (45%), Gaps = 28/307 (9%)
Query: 110 DESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQER-KVQALSEMASEQ 168
+E+ H ++++ + + +K E + + +R+ EE + K + +E +
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2233
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLK---------AEHRHRA-KILNL 218
L+ D + Q +E + +++V E+++R ++ QE + A+ R A K+L
Sbjct: 2234 LRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2292
Query: 219 KLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAA 278
K++ ++ +AE E L++++ ++ LQE+ Q++QQL Q + L A
Sbjct: 2293 KMQAVQEATRLKAEAELLQQQK-ELAQEQARRLQEDKEQMAQQLAEETQG---FQRTLEA 2348
Query: 279 FQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQ---------EI 329
+ R ++ + + +E S A ++ +A+R ++ ++ L + +
Sbjct: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2408
Query: 330 TRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQW 389
+ E +R+Q + +A+ +L+EA + E KE ++E++Q Q+ +Q
Sbjct: 2409 VQTLEIQRQQSDHDAE-RLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2465
Query: 390 YQQLQDA 396
Q LQ +
Sbjct: 2466 TQALQQS 2472
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 10/188 (5%)
Query: 145 EGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEK 204
E LR E ER+ + L + A + +E + ++Q + Q+ + + + E ++
Sbjct: 2424 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2483
Query: 205 LKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEE---------- 254
+ + +AK+ L E + + + EQ+R +++ Q R R + +++E
Sbjct: 2484 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2543
Query: 255 MLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERA 314
+ + ++L EQ + + LA R + L+ RA+ S SQ A +
Sbjct: 2544 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2603
Query: 315 LREMRDLL 322
L RD L
Sbjct: 2604 LPNGRDAL 2611
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 55.8 bits (133), Expect = 1e-07
Identities = 63/230 (27%), Positives = 107/230 (46%), Gaps = 28/230 (12%)
Query: 151 QEEQERKVQ--ALSEMASEQLKRFDEWKELKQHKEFQ---DLREVMEKSS---REALGHQ 202
+EE ER+ Q A +E A E+ +R E +LK ++ + EV ++ S EA +
Sbjct: 1593 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1652
Query: 203 EKLKAEHRHRAKILNLKLRE---AEQQRVKQAE------QERLRKEEGQIRLRA------ 247
E+ + E R R K +R+ AEQ+ KQ + Q+RL E+ IRLRA
Sbjct: 1653 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1712
Query: 248 --LYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTA 305
L+EE+ +L ++ A+ Q + L+ +LA + ++ L++ RA ES +
Sbjct: 1713 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1769
Query: 306 ESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQ 355
+S+ E R+L + A E KR++ E Q A+ ++
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1819
Score = 50.1 bits (118), Expect = 7e-06
Identities = 62/272 (22%), Positives = 114/272 (41%), Gaps = 17/272 (6%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
+E R E EL+ ++ Q L E+ REA +K A A+ L E E+
Sbjct: 1941 AEDTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1999
Query: 226 QRVKQAEQERLRKEEGQIRLRALYALQE---EMLQLSQQLD--ASEQHKALLKVDLAAFQ 280
+ K E RLR+ Q R L QE + LQ ++ A +Q + L+ L Q
Sbjct: 2000 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2059
Query: 281 TRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDK---R 337
+ +QL RA+ E+ +++ EA ++ R++ + + + ++ E++ R
Sbjct: 2060 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-----AERLKQSAEEQAQAR 2114
Query: 338 RQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDAS 397
Q + A+ +EA+ + A E A Q + K + T++ Q++
Sbjct: 2115 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2174
Query: 398 MQCVLTFEGLTNSK---DSQAKKIKMDLQKAA 426
L E + K D + +++K + +AA
Sbjct: 2175 TTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2206
Score = 48.1 bits (113), Expect = 3e-05
Identities = 52/221 (23%), Positives = 97/221 (43%), Gaps = 19/221 (8%)
Query: 151 QEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
Q+E +RK QA E+AS E + +E Q + +E+ +A + +L+
Sbjct: 1490 QDESQRKRQAEVELASRVKA------EAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1543
Query: 211 HRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLR--------ALYALQEEMLQLSQQL 262
RA+ + + L A++ + + +R E +L A+ L+EE + +QQ
Sbjct: 1544 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1603
Query: 263 DASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLL 322
+E+ + + +L +Q + N+ L + + S AE++ + E A RE R
Sbjct: 1604 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR--- 1660
Query: 323 MNLGQEITRACEDKRRQDEE-EAQVKLQEAQMQQGPEAHKE 362
G+ +A + ++E E Q +L E QQ A +E
Sbjct: 1661 -RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1700
Score = 46.6 bits (109), Expect = 8e-05
Identities = 50/241 (20%), Positives = 107/241 (44%), Gaps = 41/241 (17%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
E + RM+ E L Q +ER+ A E A E+ ++ E + + ++ +E+ ++
Sbjct: 1325 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1384
Query: 196 REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRL--RALYALQE 253
E + +E + + I + E Q+++Q+ + ++ + Q R+ ++E
Sbjct: 1385 EEVVRREEAAVDAQQQKRSI------QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1438
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
E+ + QL+A+E+ + + +L A + R + E+ ++Q EAER
Sbjct: 1439 EIRVVRLQLEATERQRGGAEGELQALRAR--------------AEEAEAQKRQAQEEAER 1484
Query: 314 ALREMRD-----------LLMNLGQEITRACEDKR--------RQDEEEAQVKLQEAQMQ 354
R+++D L + E A E +R R EEA+ +L++A+++
Sbjct: 1485 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1544
Query: 355 Q 355
+
Sbjct: 1545 R 1545
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/282 (22%), Positives = 126/282 (44%), Gaps = 15/282 (5%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
SE L+R +E + L + + ++ + E + AL Q +L H + +E +Q
Sbjct: 1324 SETLRRMEEEERLAEQQRAEERERLAEVEA--ALEKQRQLAEAHAQAKAQAEREAKELQQ 1381
Query: 226 QRVKQAEQERLRKEEGQIRLRALY-ALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGN 284
+ ++E +R+EE + + ++QEE+ QL Q +A Q KA + R
Sbjct: 1382 RM----QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1437
Query: 285 QLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEA 344
+ ++ + A +E AE + +A RA E + QE E RRQ ++E+
Sbjct: 1438 EEIRVVRLQLEA-TERQRGGAEGELQALRARAEEAEAQKRQAQE---EAERLRRQVQDES 1493
Query: 345 QVKLQEAQMQQGPEAHKEPPAPSQGPGGKQN-EDLQVKVQDITMQWYQQLQDASMQCVLT 403
Q K ++A+++ E A + Q E+L+++ ++ + Q + + Q +
Sbjct: 1494 QRK-RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1552
Query: 404 FEGLTNSKDSQAKKIKMDL-QKAATIPVS-QISTIAGSKLKE 443
E S +++ + + +K A + S Q +A ++L+E
Sbjct: 1553 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1594
Score = 44.7 bits (104), Expect = 3e-04
Identities = 60/255 (23%), Positives = 103/255 (40%), Gaps = 18/255 (7%)
Query: 109 KDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQ 168
+DESQ ++ + +K E E ++ E LRL EE ER+++ + Q
Sbjct: 1490 QDESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQ 1548
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRV 228
++ E + E Q R + + + + L+ EH A++ R A+QQ
Sbjct: 1549 VQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERRAQQQ-- 1603
Query: 229 KQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCS 288
AE ER R EE + L E L+L Q + Q K+L + + A Q + +
Sbjct: 1604 --AEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE-AEKQKEEAEREA 1659
Query: 289 LISGIIRASSESSYPTAESQAEAERALRE--------MRDLLMNLGQEITRACEDKRRQD 340
G + AE + E +R L E L+ L E + + ++ +
Sbjct: 1660 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1719
Query: 341 EEEAQVKLQEAQMQQ 355
EE A+++ + A Q
Sbjct: 1720 EELARLQREAAAATQ 1734
Score = 42.4 bits (98), Expect = 0.001
Identities = 66/226 (29%), Positives = 98/226 (43%), Gaps = 40/226 (17%)
Query: 141 MKGTEGLRLWQEEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQD-------LREVME 192
M+ + +L QE Q + LSE S Q +RF E ++ K + FQD LRE +
Sbjct: 2462 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2521
Query: 193 KSSREALGHQEKLKAE------HRHRAKI-LNLKLREAEQQRVKQAEQERLRKEEGQIRL 245
+ ++ +++L A +H A+ + K E +Q ++ +QE L EE Q RL
Sbjct: 2522 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RL 2580
Query: 246 RALYALQEEMLQLSQQLDASEQHKALL-------KVDLAAFQTRGNQLCSLISGIIRASS 298
R E LQL + EQH+A L +AA +T N +L A
Sbjct: 2581 R-------EQLQLLE-----EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2628
Query: 299 ESSYPTAESQAEAERALREMRDL----LMNLGQEITRACEDKRRQD 340
E S+ + A+R L+E L L L Q T E RR+D
Sbjct: 2629 EHSFDGLRRKVSAQR-LQEAGILSAEELQRLAQGHTTVDELARRED 2673
Score = 40.8 bits (94), Expect = 0.004
Identities = 50/234 (21%), Positives = 104/234 (44%), Gaps = 20/234 (8%)
Query: 153 EQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHR 212
E ER ++EM+ Q + ++ + ++ E E+ EK R L QEK+
Sbjct: 2367 EAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHRTELATQEKVTL----- 2416
Query: 213 AKILNLKLREAEQ--QRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKA 270
+ L ++ ++++ +R+++A E R++E + L L+ E +Q QQ ++ +A
Sbjct: 2417 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2476
Query: 271 LLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEIT 330
L + +F + + L I + ++ + A+A++ E + + QE
Sbjct: 2477 LQQ----SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2532
Query: 331 RAC----EDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQV 380
R E +RRQ E E V+ ++ ++QQ + ++ + E LQ+
Sbjct: 2533 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2586
Score = 40.4 bits (93), Expect = 0.006
Identities = 65/286 (22%), Positives = 116/286 (40%), Gaps = 29/286 (10%)
Query: 152 EEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
EE+ R S+ E + RF E E E LR + E++ R+ +E +
Sbjct: 1761 EEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRA 1815
Query: 211 HRAKILNLKLRE-AEQQRVKQAEQERLRKEEGQI-RLRALYALQEEMLQLSQQLDASEQH 268
++L KL E R+K + L+++E + RLR L ++E Q + + + QH
Sbjct: 1816 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL--AEDEAFQRRRLEEQAAQH 1873
Query: 269 KALLKVDLAAFQTRGNQLCSLISGIIR--------------ASSESSYPTAESQAEAERA 314
KA ++ LA + + G++ A S A +AE E
Sbjct: 1874 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1933
Query: 315 LREMR----DLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGP 370
L +R D L + Q A ++ EEE + + E ++Q+ A +E A +
Sbjct: 1934 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE-AARQRKA 1992
Query: 371 GGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAK 416
++ E L+ KV++ + Q+++ Q L E ++ K
Sbjct: 1993 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2038
Score = 39.3 bits (90), Expect = 0.012
Identities = 62/307 (20%), Positives = 141/307 (45%), Gaps = 28/307 (9%)
Query: 110 DESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQER-KVQALSEMASEQ 168
+E+ H ++++ + + +K E + + +R+ EE + K + +E +
Sbjct: 2182 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2241
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLK---------AEHRHRA-KILNL 218
L+ D + Q +E + +++V E+++R ++ QE + A+ R A K+L
Sbjct: 2242 LRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2300
Query: 219 KLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAA 278
K++ ++ +AE E L++++ ++ LQE+ Q++QQL Q + L A
Sbjct: 2301 KMQAVQEATRLKAEAELLQQQK-ELAQEQARRLQEDKEQMAQQLAEETQG---FQRTLEA 2356
Query: 279 FQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQ---------EI 329
+ R ++ + + +E S A ++ +A+R ++ ++ L + +
Sbjct: 2357 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2416
Query: 330 TRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQW 389
+ E +R+Q + +A+ +L+EA + E KE ++E++Q Q+ +Q
Sbjct: 2417 VQTLEIQRQQSDHDAE-RLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2473
Query: 390 YQQLQDA 396
Q LQ +
Sbjct: 2474 TQALQQS 2480
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 10/188 (5%)
Query: 145 EGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEK 204
E LR E ER+ + L + A + +E + ++Q + Q+ + + + E ++
Sbjct: 2432 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2491
Query: 205 LKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEE---------- 254
+ + +AK+ L E + + + EQ+R +++ Q R R + +++E
Sbjct: 2492 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2551
Query: 255 MLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERA 314
+ + ++L EQ + + LA R + L+ RA+ S SQ A +
Sbjct: 2552 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2611
Query: 315 LREMRDLL 322
L RD L
Sbjct: 2612 LPNGRDAL 2619
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 55.8 bits (133), Expect = 1e-07
Identities = 63/230 (27%), Positives = 107/230 (46%), Gaps = 28/230 (12%)
Query: 151 QEEQERKVQ--ALSEMASEQLKRFDEWKELKQHKEFQ---DLREVMEKSS---REALGHQ 202
+EE ER+ Q A +E A E+ +R E +LK ++ + EV ++ S EA +
Sbjct: 1634 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1693
Query: 203 EKLKAEHRHRAKILNLKLRE---AEQQRVKQAE------QERLRKEEGQIRLRA------ 247
E+ + E R R K +R+ AEQ+ KQ + Q+RL E+ IRLRA
Sbjct: 1694 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
Query: 248 --LYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTA 305
L+EE+ +L ++ A+ Q + L+ +LA + ++ L++ RA ES +
Sbjct: 1754 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRA---EMEVLLASKARAEEESRSTSE 1810
Query: 306 ESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQ 355
+S+ E R+L + A E KR++ E Q A+ ++
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1860
Score = 50.1 bits (118), Expect = 7e-06
Identities = 62/272 (22%), Positives = 114/272 (41%), Gaps = 17/272 (6%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
+E R E EL+ ++ Q L E+ REA +K A A+ L E E+
Sbjct: 1982 AEDTLRSKEQAELEAARQRQ-LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2040
Query: 226 QRVKQAEQERLRKEEGQIRLRALYALQE---EMLQLSQQLD--ASEQHKALLKVDLAAFQ 280
+ K E RLR+ Q R L QE + LQ ++ A +Q + L+ L Q
Sbjct: 2041 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2100
Query: 281 TRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDK---R 337
+ +QL RA+ E+ +++ EA ++ R++ + + + ++ E++ R
Sbjct: 2101 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE-----AERLKQSAEEQAQAR 2155
Query: 338 RQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDAS 397
Q + A+ +EA+ + A E A Q + K + T++ Q++
Sbjct: 2156 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2215
Query: 398 MQCVLTFEGLTNSK---DSQAKKIKMDLQKAA 426
L E + K D + +++K + +AA
Sbjct: 2216 TTLRLQLEETDHQKNLLDEELQRLKAEATEAA 2247
Score = 48.1 bits (113), Expect = 3e-05
Identities = 52/221 (23%), Positives = 97/221 (43%), Gaps = 19/221 (8%)
Query: 151 QEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
Q+E +RK QA E+AS E + +E Q + +E+ +A + +L+
Sbjct: 1531 QDESQRKRQAEVELASRVKA------EAEAAREKQRALQALEELRLQAEEAERRLRQAEV 1584
Query: 211 HRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLR--------ALYALQEEMLQLSQQL 262
RA+ + + L A++ + + +R E +L A+ L+EE + +QQ
Sbjct: 1585 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1644
Query: 263 DASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLL 322
+E+ + + +L +Q + N+ L + + S AE++ + E A RE R
Sbjct: 1645 AEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREAR--- 1701
Query: 323 MNLGQEITRACEDKRRQDEE-EAQVKLQEAQMQQGPEAHKE 362
G+ +A + ++E E Q +L E QQ A +E
Sbjct: 1702 -RRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1741
Score = 46.6 bits (109), Expect = 8e-05
Identities = 50/241 (20%), Positives = 107/241 (44%), Gaps = 41/241 (17%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
E + RM+ E L Q +ER+ A E A E+ ++ E + + ++ +E+ ++
Sbjct: 1366 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1425
Query: 196 REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRL--RALYALQE 253
E + +E + + I + E Q+++Q+ + ++ + Q R+ ++E
Sbjct: 1426 EEVVRREEAAVDAQQQKRSI------QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1479
Query: 254 EMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAER 313
E+ + QL+A+E+ + + +L A + R + E+ ++Q EAER
Sbjct: 1480 EIRVVRLQLEATERQRGGAEGELQALRAR--------------AEEAEAQKRQAQEEAER 1525
Query: 314 ALREMRD-----------LLMNLGQEITRACEDKR--------RQDEEEAQVKLQEAQMQ 354
R+++D L + E A E +R R EEA+ +L++A+++
Sbjct: 1526 LRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE 1585
Query: 355 Q 355
+
Sbjct: 1586 R 1586
Score = 46.2 bits (108), Expect = 1e-04
Identities = 63/282 (22%), Positives = 126/282 (44%), Gaps = 15/282 (5%)
Query: 166 SEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQ 225
SE L+R +E + L + + ++ + E + AL Q +L H + +E +Q
Sbjct: 1365 SETLRRMEEEERLAEQQRAEERERLAEVEA--ALEKQRQLAEAHAQAKAQAEREAKELQQ 1422
Query: 226 QRVKQAEQERLRKEEGQIRLRALY-ALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGN 284
+ ++E +R+EE + + ++QEE+ QL Q +A Q KA + R
Sbjct: 1423 RM----QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1478
Query: 285 QLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEA 344
+ ++ + A +E AE + +A RA E + QE E RRQ ++E+
Sbjct: 1479 EEIRVVRLQLEA-TERQRGGAEGELQALRARAEEAEAQKRQAQE---EAERLRRQVQDES 1534
Query: 345 QVKLQEAQMQQGPEAHKEPPAPSQGPGGKQN-EDLQVKVQDITMQWYQQLQDASMQCVLT 403
Q K ++A+++ E A + Q E+L+++ ++ + Q + + Q +
Sbjct: 1535 QRK-RQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1593
Query: 404 FEGLTNSKDSQAKKIKMDL-QKAATIPVS-QISTIAGSKLKE 443
E S +++ + + +K A + S Q +A ++L+E
Sbjct: 1594 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLRE 1635
Score = 44.7 bits (104), Expect = 3e-04
Identities = 60/255 (23%), Positives = 103/255 (40%), Gaps = 18/255 (7%)
Query: 109 KDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQ 168
+DESQ ++ + +K E E ++ E LRL EE ER+++ + Q
Sbjct: 1531 QDESQRKRQAEVELASRVKAEAEAAR-EKQRALQALEELRLQAEEAERRLRQAEVERARQ 1589
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRV 228
++ E + E Q R + + + + L+ EH A++ R A+QQ
Sbjct: 1590 VQVALETAQRSAEAELQSKRASFAEKTAQL---ERSLQEEHVAVAQLREEAERRAQQQ-- 1644
Query: 229 KQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCS 288
AE ER R EE + L E L+L Q + Q K+L + + A Q + +
Sbjct: 1645 --AEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAE-AEKQKEEAEREA 1700
Query: 289 LISGIIRASSESSYPTAESQAEAERALRE--------MRDLLMNLGQEITRACEDKRRQD 340
G + AE + E +R L E L+ L E + + ++ +
Sbjct: 1701 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1760
Query: 341 EEEAQVKLQEAQMQQ 355
EE A+++ + A Q
Sbjct: 1761 EELARLQREAAAATQ 1775
Score = 42.4 bits (98), Expect = 0.001
Identities = 66/226 (29%), Positives = 98/226 (43%), Gaps = 40/226 (17%)
Query: 141 MKGTEGLRLWQEEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQD-------LREVME 192
M+ + +L QE Q + LSE S Q +RF E ++ K + FQD LRE +
Sbjct: 2503 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2562
Query: 193 KSSREALGHQEKLKAE------HRHRAKI-LNLKLREAEQQRVKQAEQERLRKEEGQIRL 245
+ ++ +++L A +H A+ + K E +Q ++ +QE L EE Q RL
Sbjct: 2563 RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ-RL 2621
Query: 246 RALYALQEEMLQLSQQLDASEQHKALL-------KVDLAAFQTRGNQLCSLISGIIRASS 298
R E LQL + EQH+A L +AA +T N +L A
Sbjct: 2622 R-------EQLQLLE-----EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2669
Query: 299 ESSYPTAESQAEAERALREMRDL----LMNLGQEITRACEDKRRQD 340
E S+ + A+R L+E L L L Q T E RR+D
Sbjct: 2670 EHSFDGLRRKVSAQR-LQEAGILSAEELQRLAQGHTTVDELARRED 2714
Score = 40.8 bits (94), Expect = 0.004
Identities = 50/234 (21%), Positives = 104/234 (44%), Gaps = 20/234 (8%)
Query: 153 EQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHR 212
E ER ++EM+ Q + ++ + ++ E E+ EK R L QEK+
Sbjct: 2408 EAERLKLRVAEMSRAQARAEEDAQRFRKQAE-----EIGEKLHRTELATQEKVTL----- 2457
Query: 213 AKILNLKLREAEQ--QRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKA 270
+ L ++ ++++ +R+++A E R++E + L L+ E +Q QQ ++ +A
Sbjct: 2458 VQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA 2517
Query: 271 LLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEIT 330
L + +F + + L I + ++ + A+A++ E + + QE
Sbjct: 2518 LQQ----SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2573
Query: 331 RAC----EDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQV 380
R E +RRQ E E V+ ++ ++QQ + ++ + E LQ+
Sbjct: 2574 RLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2627
Score = 40.4 bits (93), Expect = 0.006
Identities = 65/286 (22%), Positives = 116/286 (40%), Gaps = 29/286 (10%)
Query: 152 EEQERKVQALSEMASE-QLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
EE+ R S+ E + RF E E E LR + E++ R+ +E +
Sbjct: 1802 EEESRSTSEKSKQRLEAEAGRFRELAE-----EAARLRALAEEAKRQRQLAEEDAARQRA 1856
Query: 211 HRAKILNLKLRE-AEQQRVKQAEQERLRKEEGQI-RLRALYALQEEMLQLSQQLDASEQH 268
++L KL E R+K + L+++E + RLR L ++E Q + + + QH
Sbjct: 1857 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL--AEDEAFQRRRLEEQAAQH 1914
Query: 269 KALLKVDLAAFQTRGNQLCSLISGIIR--------------ASSESSYPTAESQAEAERA 314
KA ++ LA + + G++ A S A +AE E
Sbjct: 1915 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1974
Query: 315 LREMR----DLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGP 370
L +R D L + Q A ++ EEE + + E ++Q+ A +E A +
Sbjct: 1975 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE-AARQRKA 2033
Query: 371 GGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLTNSKDSQAK 416
++ E L+ KV++ + Q+++ Q L E ++ K
Sbjct: 2034 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2079
Score = 39.3 bits (90), Expect = 0.012
Identities = 62/307 (20%), Positives = 141/307 (45%), Gaps = 28/307 (9%)
Query: 110 DESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQER-KVQALSEMASEQ 168
+E+ H ++++ + + +K E + + +R+ EE + K + +E +
Sbjct: 2223 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2282
Query: 169 LKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLK---------AEHRHRA-KILNL 218
L+ D + Q +E + +++V E+++R ++ QE + A+ R A K+L
Sbjct: 2283 LRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2341
Query: 219 KLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAA 278
K++ ++ +AE E L++++ ++ LQE+ Q++QQL Q + L A
Sbjct: 2342 KMQAVQEATRLKAEAELLQQQK-ELAQEQARRLQEDKEQMAQQLAEETQG---FQRTLEA 2397
Query: 279 FQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQ---------EI 329
+ R ++ + + +E S A ++ +A+R ++ ++ L + +
Sbjct: 2398 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL 2457
Query: 330 TRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQW 389
+ E +R+Q + +A+ +L+EA + E KE ++E++Q Q+ +Q
Sbjct: 2458 VQTLEIQRQQSDHDAE-RLREAIAEL--EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQE 2514
Query: 390 YQQLQDA 396
Q LQ +
Sbjct: 2515 TQALQQS 2521
Score = 35.4 bits (80), Expect = 0.18
Identities = 40/188 (21%), Positives = 80/188 (42%), Gaps = 10/188 (5%)
Query: 145 EGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEK 204
E LR E ER+ + L + A + +E + ++Q + Q+ + + + E ++
Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2532
Query: 205 LKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEE---------- 254
+ + +AK+ L E + + + EQ+R +++ Q R R + +++E
Sbjct: 2533 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2592
Query: 255 MLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERA 314
+ + ++L EQ + + LA R + L+ RA+ S SQ A +
Sbjct: 2593 VRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKT 2652
Query: 315 LREMRDLL 322
L RD L
Sbjct: 2653 LPNGRDAL 2660
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 55.1 bits (131), Expect = 2e-07
Identities = 60/254 (23%), Positives = 118/254 (46%), Gaps = 23/254 (9%)
Query: 134 MYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEK 193
M+E +M+ E + +W E+E K++ L EM E+ ++ E +E K H++ + +RE EK
Sbjct: 344 MWEKEEKMRRQEEM-MW--EKEEKMRRLEEMMWEKEEKIRELEE-KMHEQ-EKIREQEEK 398
Query: 194 SSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEG---QIRLRALYA 250
E +++ + E + K+RE E+ ++++ E++ R+EE Q ++R
Sbjct: 399 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEE-KIREQEKKMWRQEEKIHEQEKIREEEK 457
Query: 251 LQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAE 310
QE+ Q+ EQ + + + Q + IR E + E +
Sbjct: 458 RQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK-----------IRKQEEKVWRQEEKMHD 506
Query: 311 AERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGP 370
E +RE + + ++I R E+K R+ EE +++ QE MQ+ E E Q
Sbjct: 507 QEEKIREQEEKMWRQEEKI-REQEEKIREQEE--KIREQEEMMQEQEEKMGEQEEKMQEQ 563
Query: 371 GGKQNEDLQVKVQD 384
+ ++ +++ Q+
Sbjct: 564 EKMRRQEEKIREQE 577
Score = 49.7 bits (117), Expect = 9e-06
Identities = 50/232 (21%), Positives = 103/232 (44%), Gaps = 29/232 (12%)
Query: 153 EQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS----REALGHQEKLKAE 208
EQE+K+ E EQ K +E K +Q + ++ ++ E+ +E + QEK++ +
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQ 493
Query: 209 H----RHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDA 264
R K+ + + + EQ+ ++E++R++E +IR + ++E + Q+
Sbjct: 494 EEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKM 553
Query: 265 SEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMN 324
EQ + + + + R + IR E E E E +RE +++
Sbjct: 554 GEQEEKMQEQEK---MRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQE 610
Query: 325 ----LGQEITRACEDK----------RRQD----EEEAQVKLQEAQMQQGPE 358
+ ++ + CE + RRQ+ E+E +++ QE +MQ+ E
Sbjct: 611 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
Score = 44.7 bits (104), Expect = 3e-04
Identities = 45/234 (19%), Positives = 100/234 (42%), Gaps = 33/234 (14%)
Query: 133 RMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVME 192
++ EL +M E +R EQE K Q ++ ++ ++ E K +Q ++ ++ E +
Sbjct: 378 KIRELEEKMHEQEKIR----EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 433
Query: 193 KSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQ 252
+ ++ +EK+ + + R + + E +Q K EQE + +++ ++ + Q
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQ 493
Query: 253 EEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAE 312
EE + ++ ++ K IR E + E E E
Sbjct: 494 EEKVWRQEEKMHDQEEK------------------------IREQEEKMWRQEEKIREQE 529
Query: 313 RALREMRDLLMNLGQEITRACEDKRRQDEEEAQ----VKLQEAQMQQGPEAHKE 362
+RE + + +E+ + E+K + EE+ Q ++ QE ++++ E +E
Sbjct: 530 EKIREQEEKIRE-QEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIRE 582
Score = 44.3 bits (103), Expect = 4e-04
Identities = 33/132 (25%), Positives = 59/132 (44%), Gaps = 11/132 (8%)
Query: 153 EQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHR 212
EQE K++ EM EQ ++ E +E Q +E +E + E + Q++ E +
Sbjct: 534 EQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEK 593
Query: 213 AKILNLKLREAE-----------QQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQ 261
K+RE E +Q K EQE +E+ + R + E+ ++L QQ
Sbjct: 594 IWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 653
Query: 262 LDASEQHKALLK 273
+ ++H+ L+
Sbjct: 654 EEKMQEHQEHLE 665
Score = 43.9 bits (102), Expect = 5e-04
Identities = 27/120 (22%), Positives = 62/120 (51%), Gaps = 2/120 (1%)
Query: 148 RLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKA 207
++W+ QE K++ E EQ ++ E +E+ Q +E + + + +E + QE+
Sbjct: 517 KMWR--QEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIR 574
Query: 208 EHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQ 267
E + + K+RE E++ +Q E+ R ++E Q + ++ +E+M + +++ E+
Sbjct: 575 EQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 634
Score = 38.5 bits (88), Expect = 0.021
Identities = 56/296 (18%), Positives = 123/296 (41%), Gaps = 26/296 (8%)
Query: 87 KSPDASSAFSPASPATPNGTKGKDESQHTESMVLQSSRG---IKVEGCVRMYELVHRMKG 143
K DA S + T K K+ + +++S + + V+ R E +
Sbjct: 200 KERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP 259
Query: 144 TEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQE 203
+ L+ + +++Q++S Q++ + W L Q +E E M + + +E
Sbjct: 260 QQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQE-----EKMWRQEEKIQEWEE 314
Query: 204 KLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLD 263
K++ E + + K+RE E++ +Q E ++E+ + + ++ +E+M +L + +
Sbjct: 315 KIQ-EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMW 373
Query: 264 ASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLM 323
E+ L+ + + IR E E + E+ R+ ++ M
Sbjct: 374 EKEEKIRELEEKMHEQEK------------IREQEEK---RQEEEKIREQEKRQEQEAKM 418
Query: 324 NLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQ 379
+E R E+K R E+E ++ QE ++ + + +E Q +Q E ++
Sbjct: 419 WRQEEKIREQEEKIR--EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR 472
>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
sapiens]
Length = 956
Score = 54.7 bits (130), Expect = 3e-07
Identities = 54/185 (29%), Positives = 89/185 (48%), Gaps = 23/185 (12%)
Query: 61 QENQPLSETSPSSTSASALDQPSFVPKSPDASSAFSPASPATPNGTKGKDESQHTESMVL 120
+E+ LS +S SS S+++ P P P S+ SP +TP +
Sbjct: 277 EEDSVLSHSSLSSPSSTS--SPEGPPAPPKQHSSTSPFPTSTP-----------LRRITK 323
Query: 121 QSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQ 180
+ +G + +R+ R+ LR +EE+E+ + E K+ +E KELK+
Sbjct: 324 KFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKE 383
Query: 181 HKEFQDLREVMEKSSREALGHQEKLKAEHR-HRAKILNLKLREAEQQRVKQAEQERLRKE 239
KE ++ RE EK E +++LK E R R + L KL E + K+ E++RLR+E
Sbjct: 384 -KERREKREKDEKEKAE----KQRLKEERRKERQEALEAKLEE----KRKKEEEKRLREE 434
Query: 240 EGQIR 244
E +I+
Sbjct: 435 EKRIK 439
Score = 32.7 bits (73), Expect = 1.2
Identities = 33/137 (24%), Positives = 64/137 (46%), Gaps = 16/137 (11%)
Query: 230 QAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSL 289
Q +QERL K Q++LRA +E++ + +++ + K + +L + R +
Sbjct: 338 QRDQERLGK---QLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKR---- 390
Query: 290 ISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQ 349
+ AE Q E +E ++ L +E R E+++R EEE ++K +
Sbjct: 391 --------EKDEKEKAEKQRLKEERRKERQEALEAKLEE-KRKKEEEKRLREEEKRIKAE 441
Query: 350 EAQMQQGPEAHKEPPAP 366
+A++ + + K P AP
Sbjct: 442 KAEITRFFQKPKTPQAP 458
Score = 31.2 bits (69), Expect = 3.4
Identities = 25/98 (25%), Positives = 45/98 (45%), Gaps = 22/98 (22%)
Query: 196 REALGHQEKLKAEHRHRAKILN--------LKLREAEQQRVKQ--------------AEQ 233
+E LG Q KL+AE + K+ K ++ E++ +K+ AE+
Sbjct: 341 QERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEK 400
Query: 234 ERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKAL 271
+RL++E + R AL A EE + ++ E+ K +
Sbjct: 401 QRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRI 438
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin
(with transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 54.3 bits (129), Expect = 4e-07
Identities = 74/377 (19%), Positives = 165/377 (43%), Gaps = 25/377 (6%)
Query: 106 TKGKDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQERKVQALSEMA 165
T+ + E Q ++ + +++E + + T +L Q + E+ Q+ +EM
Sbjct: 124 TEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEME 183
Query: 166 SEQLKRFDEWKELKQHKEF-QDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAE 224
+ + ++L++ +EF L+ + ++ E Q + + R ++ +L E E
Sbjct: 184 EFVMMK----QQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQV---RLHEDE 236
Query: 225 Q-QRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRG 283
Q V QA+ E +++ ++ R L +E ++ +Q +D LL+ +L A + R
Sbjct: 237 LLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVD-------LLQQELTAAEQR- 288
Query: 284 NQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLM--------NLGQEITRACED 335
NQ+ S + A + T E++ E + L E +L + NL +E+ E
Sbjct: 289 NQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ 348
Query: 336 KRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQD 395
+ + +A+++ + + ++Q +A E K ++LQ + Q + LQD
Sbjct: 349 FEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQD 408
Query: 396 ASMQCVLTFEGLTNSKDSQAKKIKMDLQKAATIPVSQISTIAGSKLKEIFDKIHSLLSGK 455
+ Q V + + + +D +K K Q +P+ Q T + + +++++ ++ +
Sbjct: 409 KNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEE 468
Query: 456 PVQSGGRSVSVTLNPQG 472
+ S + V N +G
Sbjct: 469 NIASLQKRVVELENEKG 485
Score = 41.6 bits (96), Expect = 0.003
Identities = 62/319 (19%), Positives = 132/319 (41%), Gaps = 34/319 (10%)
Query: 137 LVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSR 196
L+ ++ +G +E+ K+ L++ E+L R + KE + +E DL E +
Sbjct: 1873 LLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAE-EEKDDLEERLMNQLA 1931
Query: 197 EALGH-----QEKLKAEHRHR---AKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRAL 248
E G Q+ A+ ++ +++ NLK +E + KQ + K E +IR L
Sbjct: 1932 ELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYL 1991
Query: 249 YALQ---------EEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGI------ 293
+Q +L + L +Q L+ D +Q + + L + +
Sbjct: 1992 EKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTE 2051
Query: 294 ----IRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEE-EAQVKL 348
+ + E+ E + +A+ L + LL + E R D + +E ++ +
Sbjct: 2052 SQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKES 2111
Query: 349 QEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQCVLTFEGLT 408
++QM+Q E + ++ K+ +++Q K+ D + L++ + +T
Sbjct: 2112 VKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL-DALRREKVHLEETIGEIQVTL---- 2166
Query: 409 NSKDSQAKKIKMDLQKAAT 427
N KD + ++++ +L T
Sbjct: 2167 NKKDKEVQQLQENLDSTVT 2185
Score = 38.1 bits (87), Expect = 0.028
Identities = 28/120 (23%), Positives = 57/120 (47%), Gaps = 10/120 (8%)
Query: 152 EEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRH 211
E++E+ V+ + + S ++ EW+E +HKE Q E++ +S E++ +H
Sbjct: 1581 EDKEKLVKEIESLKSSKIAESTEWQE--KHKELQKEYEILLQSYENVSNEAERI--QHVV 1636
Query: 212 RAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKAL 271
A +R+ +Q+ + K+E + +L+ EEM + ++ S+Q K L
Sbjct: 1637 EA------VRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKIL 1690
Score = 35.8 bits (81), Expect = 0.14
Identities = 61/265 (23%), Positives = 111/265 (41%), Gaps = 63/265 (23%)
Query: 142 KGTEGLRLWQ-EEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALG 200
+GT GL Q + +E +V LS + S KR E +E +L V ++++++
Sbjct: 2624 EGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEE--------ELVCVQKEAAKKVGE 2675
Query: 201 HQEKLKAEHRHRAKILNLKLREAE--QQRVKQAEQERLRKEEGQIRL------------- 245
++KLK E +H + E E ++RV + ++ + E+ + +
Sbjct: 2676 IEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQS 2735
Query: 246 --RALYALQ-------EEMLQLSQQLDASEQHKALLKVD--------------------- 275
R++ +LQ EE+ +L ++ DAS + A LK
Sbjct: 2736 FGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNST 2795
Query: 276 ----LAAFQTRGNQLCSLISGIIRASS--ESSYPTAESQAEAERALREMRDLLMNLGQEI 329
L+ + QL S ++ SS E SY +S ++A +L+ RD L N ++
Sbjct: 2796 EENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKF 2855
Query: 330 TRACEDKRRQDEEEAQVKLQEAQMQ 354
++ E K+R AQ A++Q
Sbjct: 2856 RKSEEGKQR---SAAQPSTSPAEVQ 2877
Score = 33.5 bits (75), Expect = 0.69
Identities = 55/278 (19%), Positives = 125/278 (44%), Gaps = 28/278 (10%)
Query: 148 RLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKA 207
++W+ + + +VQ L + + L+ E KEL + ++ R + S E + +LK+
Sbjct: 2262 QIWESKAQTEVQ-LQQKVCDTLQ--GENKELLS--QLEETRHLYHSSQNELAKLESELKS 2316
Query: 208 EHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIR-LRALYALQEEMLQLSQQLDASE 266
+ N L + ++Q K + +R++E I+ + Y E LQ S++L S
Sbjct: 2317 LKDQLTDLSN-SLEKCKEQ--KGNLEGIIRQQEADIQNSKFSYEQLETDLQASREL-TSR 2372
Query: 267 QHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLG 326
H+ + + ++ SL+SG A + AE + + ++ ++E+ +LL
Sbjct: 2373 LHEEI--------NMKEQKIISLLSGKEEAIQVA---IAELRQQHDKEIKELENLLSQEE 2421
Query: 327 QE-ITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDI 385
+E I E+K+ D+ ++ + ++ + + + + QN+ +D
Sbjct: 2422 EENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQND------RDR 2475
Query: 386 TMQWYQQLQDASMQCVLTFEGLTNSKDSQAKKIKMDLQ 423
+ YQQL++ + +L + L ++ K+K +++
Sbjct: 2476 IVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIR 2513
Score = 33.5 bits (75), Expect = 0.69
Identities = 46/217 (21%), Positives = 90/217 (41%), Gaps = 26/217 (11%)
Query: 157 KVQALSEMASEQLKRFDEWKELKQHKEF----------------QDLREVM---EKSSRE 197
K Q + E A+E K +E + L+ H + +DL +V+ + ++
Sbjct: 2494 KDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQ 2553
Query: 198 ALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQ 257
L Q + E ++ L KL+E+E+ +EE Q + + +L+ + Q
Sbjct: 2554 LLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQ 2613
Query: 258 LSQQLDASEQH--KALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERAL 315
L++Q+ A ++ L L + ++L +L S + +E Q EA + +
Sbjct: 2614 LTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKV 2673
Query: 316 REMRDLLMNLGQEITRACEDK--RRQDEEEAQVKLQE 350
E+ D L +E+ D R + E A+ ++ E
Sbjct: 2674 GEIED---KLKKELKHLHHDAGIMRNETETAEERVAE 2707
Score = 30.8 bits (68), Expect = 4.4
Identities = 56/253 (22%), Positives = 105/253 (41%), Gaps = 45/253 (17%)
Query: 152 EEQERKVQALSE-MASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEHR 210
E+ +VQ+ S+ MAS Q +R W EL++ ++ ++ G Q
Sbjct: 2825 EDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEE-------------GKQRSAAQPST 2871
Query: 211 HRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKA 270
A++ +LK + Q +++RL KE L LQ++ LQ++Q++ +E H
Sbjct: 2872 SPAEVQSLKKAMSSLQN----DRDRLLKE--------LKNLQQQYLQINQEI--TELHP- 2916
Query: 271 LLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEIT 330
LK L +Q + + ++ +R S+ Q E++ E+ + M ++
Sbjct: 2917 -LKAQLQEYQDK-TKAFQIMQEELR-QENLSWQHELHQLRMEKSSWEIHERRMK--EQYL 2971
Query: 331 RACEDKRRQDE------EEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQN-----EDLQ 379
A DK +Q E + + Q + + P S P G QN E L+
Sbjct: 2972 MAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLR 3031
Query: 380 VKVQDITMQWYQQ 392
++ D + +Q+
Sbjct: 3032 TQLNDSLKEIHQK 3044
Score = 30.4 bits (67), Expect = 5.8
Identities = 52/306 (16%), Positives = 125/306 (40%), Gaps = 59/306 (19%)
Query: 152 EEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDL-REVMEKSSREALGHQEKLKAEHR 210
EE K Q ++ + + R + KE K +E L R +E+ ++ + ++ A+++
Sbjct: 1473 EESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNK 1532
Query: 211 HRAKILN--LKLREAEQQRVKQAEQERLRK-------EEGQIRLRALYALQEEMLQLSQQ 261
+ +L L+E + + + ++ L E ++ L L +E++++ +
Sbjct: 1533 EKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIES 1592
Query: 262 LDAS---------EQHKALLK---VDLAAFQTRGNQLCSL-------------ISGIIRA 296
L +S E+HK L K + L +++ N+ + + G +R+
Sbjct: 1593 LKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRS 1652
Query: 297 SSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQG 356
+ + T + EAE+ + EM++ + K + +++ ++L+E +
Sbjct: 1653 TEANKKETEKQLQEAEQEMEEMKEKMR------------KFAKSKQQKILELEEENDRLR 1700
Query: 357 PEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQ---CVLTFEGLTNSKDS 413
E H P G ++ + ++L+ M+ F+ L + KDS
Sbjct: 1701 AEVH---------PAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDS 1751
Query: 414 QAKKIK 419
+++++
Sbjct: 1752 LSEEVQ 1757
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 53.9 bits (128), Expect = 5e-07
Identities = 83/392 (21%), Positives = 166/392 (42%), Gaps = 41/392 (10%)
Query: 100 PATPNGTKGKDESQHTESMVLQSSRGIK--VEGCVRMYELVHRMK-GTEGLRLWQEEQER 156
P T +G G ESQ E ++S + V V E+ + G L+L Q EQ+
Sbjct: 39 PDTLSGGSGGSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQP 98
Query: 157 KVQALSEMASEQLKRFDEWKELKQHKEFQDLREV--MEKSSREALGHQEKLKAEHRHRAK 214
+ Q + EQL++ EL+Q + +++ +++ +++ HQE LK E
Sbjct: 99 EPQ--QQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQE-LKPE------ 149
Query: 215 ILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKV 274
L+L +QQ Q QE+ R ++ Q +L+ A ++++LQ +QL Q + LL+
Sbjct: 150 ---LQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQ 206
Query: 275 DLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACE 334
Q + QL + + Q + E+ ++ + LL+ ++ +
Sbjct: 207 QQEQLQQQ--QL---------LQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLL 255
Query: 335 DKRRQDEEEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQ 394
+++ ++ ++ Q+AQ+QQ ++ Q Q + L + Q+ Q QQLQ
Sbjct: 256 QQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQ-----QQQQLLQQQQEQLQQ--QQLQ 308
Query: 395 ------DASMQCVLTFEGLTNSKDSQAKKIKMDLQKAATIPVSQISTIAGSKLKEIFDKI 448
+ + L + + + ++ + +L++ + Q KL+E ++
Sbjct: 309 PPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQQL 368
Query: 449 HSLLSGKPVQSGGRSVSVTLNPQGLDFVQYKL 480
L + Q + V + L P L Q ++
Sbjct: 369 EQQLEQQQQQLEQQEVQLELTPVELGAQQQEV 400
>gi|154354985 hook homolog 2 isoform 1 [Homo sapiens]
Length = 719
Score = 53.1 bits (126), Expect = 8e-07
Identities = 72/299 (24%), Positives = 126/299 (42%), Gaps = 42/299 (14%)
Query: 143 GTEGLRLWQEEQERKV-------QALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
G E RL E ER+V QAL+ +A E DE EL+Q E E S
Sbjct: 258 GREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSC 317
Query: 196 REALGHQEKLK----------AEHRHRAKILNLKLREAEQQRVK-QAEQERLRKEEGQIR 244
R LG +L+ A H R + L +LR A R + +A++ ++++ +GQ +
Sbjct: 318 RRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQ 377
Query: 245 LRALYALQ--EEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQL-CSLIS--GIIRAS-S 298
A+ A + E L ++ ++ + K L + + + +L C+ + G+ +A S
Sbjct: 378 EEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPS 437
Query: 299 ESSYPTAESQAEAERALREMRDLLMNLGQEITRACE----DKRRQDE------------- 341
T AE E+R+ L+ L E R C D+ RQ+E
Sbjct: 438 LDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARH 497
Query: 342 -EEAQVKLQEAQMQQGPEAHKEPPAPSQGPGGKQNEDLQVKVQDITMQWYQQLQDASMQ 399
E Q +L + Q+ + ++ Q GGK + + + ++ + Q+L +A ++
Sbjct: 498 GLETQHRLNQQQLSELRAQVEDLQKALQEQGGKTEDAISILLKRKLEEHLQKLHEADLE 556
Score = 39.3 bits (90), Expect = 0.012
Identities = 56/246 (22%), Positives = 104/246 (42%), Gaps = 53/246 (21%)
Query: 163 EMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQ----------------EKLK 206
E + ++R +E QH + ++E+M K + ++L + E+ +
Sbjct: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
Query: 207 AEHRHRAKILNLK----LREAEQQRVKQAE---QERLRKEEGQ----IRLRALYALQEEM 255
+ + L+L+ L E+Q + Q +ER+ + EG+ + + L LQ ++
Sbjct: 186 EGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQL 245
Query: 256 LQLSQQ---LDASEQHKAL----LKVDLAAFQTRGNQLCSLISGI---------IRASSE 299
QL ++ L++ + + L L+ ++A Q R L SL +R SSE
Sbjct: 246 EQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSE 305
Query: 300 SSYPTAESQAEAERALREMRDLLMNLGQ---------EITRACEDK-RRQDEEEAQVKLQ 349
+ + R L E+R+L + Q E TR ED+ RR AQ++ Q
Sbjct: 306 RAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQ 365
Query: 350 EAQMQQ 355
Q+Q+
Sbjct: 366 RRQVQE 371
Score = 30.0 bits (66), Expect = 7.6
Identities = 45/192 (23%), Positives = 78/192 (40%), Gaps = 22/192 (11%)
Query: 177 ELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERL 236
+L+Q +E E + R E+ AE +HR + L +EA+ + + E +
Sbjct: 244 QLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQS 303
Query: 237 RKEEGQI---------RLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLC 287
+ GQ+ RL L L+ ++ QL ++ + L+ +L R L
Sbjct: 304 SERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL----RRAGSLR 359
Query: 288 SLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEE----- 342
+ + R E E +AE+ L E R NL ++ ++K R E
Sbjct: 360 AQLEAQRRQVQELQGQRQEEAMKAEKWLFECR----NLEEKYESVTKEKERLLAERDSLR 415
Query: 343 EAQVKLQEAQMQ 354
EA +L+ AQ+Q
Sbjct: 416 EANEELRCAQLQ 427
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 53.1 bits (126), Expect = 8e-07
Identities = 91/377 (24%), Positives = 164/377 (43%), Gaps = 50/377 (13%)
Query: 107 KGKDESQHTESMVLQSSRGIKVEGCVRMYELVHRMKGTEGLRLWQEEQE----RKVQALS 162
+GK E + +++ +Q + IK E R+ EL ++ R E+Q R+++ +S
Sbjct: 1095 QGKIEDE--QALAIQLQKKIK-ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1151
Query: 163 EMASEQLKRFDEWKEL--KQHKEFQDLREVMEKSSREALGHQEKLKA-EHRHRAKILNLK 219
E E E+ K+ EFQ +R +E+S+ L H+ A +H + L
Sbjct: 1152 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEST---LQHEATAAALRKKHADSVAELG 1208
Query: 220 LREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAF 279
+ QRVKQ +L KE+ ++++ + L M +S+ E+ L+ L+
Sbjct: 1209 EQIDSLQRVKQ----KLEKEKSELKME-INDLASNMETVSKAKANFEKMCRTLEDQLSEI 1263
Query: 280 QTRGNQLCSLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLG---QEITRACEDK 336
+T+ + LI+ + S++ + ES E R L E ++ L Q T+ E+
Sbjct: 1264 KTKEEEQQRLINEL---SAQKARLHTES-GEFSRQLDEKDAMVSQLSRGKQAFTQQIEEL 1319
Query: 337 RRQDEEEAQVK------LQEAQ-----MQQGPEAHKEPPAPSQGPGGKQNEDL---QVKV 382
+RQ EEE + K LQ A+ +++ E +E A Q K N ++ + K
Sbjct: 1320 KRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKY 1379
Query: 383 QDITMQWYQQLQDASMQCVLTFEG------LTNSKDSQAKKIKMDLQKAA-----TIPVS 431
+ +Q ++L++A + + NSK + +K K LQ + S
Sbjct: 1380 ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERS 1439
Query: 432 QISTIAGSKLKEIFDKI 448
+ IA K + FDK+
Sbjct: 1440 NAACIALDKKQRNFDKV 1456
Score = 34.3 bits (77), Expect = 0.40
Identities = 42/189 (22%), Positives = 81/189 (42%), Gaps = 35/189 (18%)
Query: 177 ELKQHKEFQDLREVME--KSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQE 234
E K K D + E K ++ H E++K K L L+L EAEQ +K +++
Sbjct: 1756 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQ 1815
Query: 235 RLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGII 294
++K E ++R +L ++++ ++H L + R +L
Sbjct: 1816 -IQKLEARVR------------ELESEVESEQKHNVEAVKGLRKHERRVKEL-------- 1854
Query: 295 RASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQE-AQM 353
+Y T E + + + ++DL+ L Q +A + + + EE++ V L + ++
Sbjct: 1855 ------TYQTEEDR----KNILRLQDLVDKL-QTKVKAYKRQAEEAEEQSNVNLAKFRKL 1903
Query: 354 QQGPEAHKE 362
Q E KE
Sbjct: 1904 QHELEEAKE 1912
Score = 33.9 bits (76), Expect = 0.52
Identities = 47/193 (24%), Positives = 84/193 (43%), Gaps = 18/193 (9%)
Query: 91 ASSAFSPASPATPNGTKGKDESQHTESMVLQSSRGIKVEGCVRMYELVH-RMKGTEGLRL 149
A A + A+ K +D S H E M + +K + +R+ E +KG G +
Sbjct: 1759 AKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK-DLQLRLDEAEQLALKG--GKKQ 1815
Query: 150 WQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAEH 209
Q+ + R + SE+ SEQ + K L++H+ R V E L +Q + ++
Sbjct: 1816 IQKLEARVRELESEVESEQKHNVEAVKGLRKHE-----RRVKE------LTYQTEEDRKN 1864
Query: 210 RHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRLRALYALQEEMLQLSQQLDASEQHK 269
R + L KL+ + +QAE+ +E+ + L LQ E+ + ++ D +E
Sbjct: 1865 ILRLQDLVDKLQTKVKAYKRQAEE---AEEQSNVNLAKFRKLQHELEEAKERADIAESQV 1921
Query: 270 ALLKVDLAAFQTR 282
L+V T+
Sbjct: 1922 NKLRVKSREVHTK 1934
Score = 32.3 bits (72), Expect = 1.5
Identities = 45/230 (19%), Positives = 95/230 (41%), Gaps = 36/230 (15%)
Query: 151 QEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQEKLKAE-- 208
+ E +RK+ E +QLKR L+ + Q + +S +AL ++K++ +
Sbjct: 1573 KSEIDRKIAEKDEEL-DQLKR----NHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLN 1627
Query: 209 -------HRHRAKILNLKLREAEQQRVKQAE---------QERLRKEEGQIRLRALYALQ 252
H +R L+ Q +K + Q+ L+++ + RA +Q
Sbjct: 1628 EMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRA-NLMQ 1686
Query: 253 EEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLCSLISGIIRASSESSYPTAESQAEAE 312
E+ +L L+ +E+ + + + +L R L + + +I + ++ Q E E
Sbjct: 1687 AEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746
Query: 313 RALREMRDLLMNLGQEITRACEDKRRQDEEEAQVKLQEAQMQQGPEAHKE 362
++E R+ E+K ++ +A + +E + +Q AH E
Sbjct: 1747 DIVQEARN------------AEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784
>gi|154354987 hook homolog 2 isoform 2 [Homo sapiens]
Length = 717
Score = 52.8 bits (125), Expect = 1e-06
Identities = 72/269 (26%), Positives = 116/269 (43%), Gaps = 27/269 (10%)
Query: 143 GTEGLRLWQEEQERKV-------QALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
G E RL E ER+V QAL+ +A E DE EL+Q E E S
Sbjct: 258 GREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSERAGQLEATLTSC 317
Query: 196 REALGHQEKLK----------AEHRHRAKILNLKLREAEQQRVK-QAEQERLRKEEGQIR 244
R LG +L+ A H R + L +LR A R + +A++ ++++ +GQ +
Sbjct: 318 RRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQRRQVQELQGQRQ 377
Query: 245 LRALYALQ--EEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQL-CSLIS--GIIRAS-S 298
A+ A + E L ++ ++ + K L + + + +L C+ + G+ +A S
Sbjct: 378 EEAMKAEKWLFECRNLEEKYESVTKEKERLLAERDSLREANEELRCAQLQPRGLTQADPS 437
Query: 299 ESSYPTAESQAEAERALREMRDLLMNLGQEITRAC--EDKRRQDEEEAQVKLQEA-QMQQ 355
T AE E+R+ L+ L E R C E R+ +EE Q L++A + +
Sbjct: 438 LDPTSTPVDNLAAEILPAELRETLLRLQLENKRLCRQEAADRERQEELQRHLEDANRARH 497
Query: 356 GPEAHKEPPAPSQGPGGKQNEDLQVKVQD 384
G E Q EDLQ +Q+
Sbjct: 498 GLETQHRLNQQQLSELRAQVEDLQKALQE 526
Score = 39.3 bits (90), Expect = 0.012
Identities = 56/246 (22%), Positives = 104/246 (42%), Gaps = 53/246 (21%)
Query: 163 EMASEQLKRFDEWKELKQHKEFQDLREVMEKSSREALGHQ----------------EKLK 206
E + ++R +E QH + ++E+M K + ++L + E+ +
Sbjct: 126 EKKQDHIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPETYGNFDSQSRRYYFLSEEAE 185
Query: 207 AEHRHRAKILNLK----LREAEQQRVKQAE---QERLRKEEGQ----IRLRALYALQEEM 255
+ + L+L+ L E+Q + Q +ER+ + EG+ + + L LQ ++
Sbjct: 186 EGDELQQRCLDLERQLMLLSEEKQSLAQENAGLRERMGRPEGEGTPGLTAKKLLLLQSQL 245
Query: 256 LQLSQQ---LDASEQHKAL----LKVDLAAFQTRGNQLCSLISGI---------IRASSE 299
QL ++ L++ + + L L+ ++A Q R L SL +R SSE
Sbjct: 246 EQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQSSE 305
Query: 300 SSYPTAESQAEAERALREMRDLLMNLGQ---------EITRACEDK-RRQDEEEAQVKLQ 349
+ + R L E+R+L + Q E TR ED+ RR AQ++ Q
Sbjct: 306 RAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDELRRAGSLRAQLEAQ 365
Query: 350 EAQMQQ 355
Q+Q+
Sbjct: 366 RRQVQE 371
Score = 30.0 bits (66), Expect = 7.6
Identities = 45/192 (23%), Positives = 78/192 (40%), Gaps = 22/192 (11%)
Query: 177 ELKQHKEFQDLREVMEKSSREALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERL 236
+L+Q +E E + R E+ AE +HR + L +EA+ + + E +
Sbjct: 244 QLEQLQEENFRLESGREDERLRCAELEREVAELQHRNQALTSLAQEAQALKDEMDELRQS 303
Query: 237 RKEEGQI---------RLRALYALQEEMLQLSQQLDASEQHKALLKVDLAAFQTRGNQLC 287
+ GQ+ RL L L+ ++ QL ++ + L+ +L R L
Sbjct: 304 SERAGQLEATLTSCRRRLGELRELRRQVRQLEERNAGHAERTRQLEDEL----RRAGSLR 359
Query: 288 SLISGIIRASSESSYPTAESQAEAERALREMRDLLMNLGQEITRACEDKRRQDEE----- 342
+ + R E E +AE+ L E R NL ++ ++K R E
Sbjct: 360 AQLEAQRRQVQELQGQRQEEAMKAEKWLFECR----NLEEKYESVTKEKERLLAERDSLR 415
Query: 343 EAQVKLQEAQMQ 354
EA +L+ AQ+Q
Sbjct: 416 EANEELRCAQLQ 427
>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
sapiens]
Length = 693
Score = 52.8 bits (125), Expect = 1e-06
Identities = 42/138 (30%), Positives = 71/138 (51%), Gaps = 10/138 (7%)
Query: 136 ELVHRMKGTEGLRLWQEEQERKVQALSEMASEQLKRFDEWKELKQHKEFQDLREVMEKSS 195
E H + EGL + Q QALS ++ EQ +R E +E+ + +E Q +RE
Sbjct: 303 EAKHLRQEVEGLEGKLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEVQRVRE------ 356
Query: 196 REALGHQEKLKAEHRHRAKILNLKLREAEQQRVKQAEQERLRKEEGQIRL--RALYALQE 253
+E L Q + E + + +LR+ EQ+ KQ +ERLRKEE +++ + L+ +E
Sbjct: 357 QERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQ--EERLRKEEERLQKQEKRLWDQEE 414
Query: 254 EMLQLSQQLDASEQHKAL 271
+ + ++L E+ AL
Sbjct: 415 RLWKKEERLQKQEERLAL 432
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.130 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,333,509
Number of Sequences: 37866
Number of extensions: 1201479
Number of successful extensions: 11714
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 145
Number of HSP's successfully gapped in prelim test: 763
Number of HSP's that attempted gapping in prelim test: 8023
Number of HSP's gapped (non-prelim): 2691
length of query: 698
length of database: 18,247,518
effective HSP length: 109
effective length of query: 589
effective length of database: 14,120,124
effective search space: 8316753036
effective search space used: 8316753036
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.