Search of human proteins with 51093830

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|51093830 bicaudal D homolog 1 isoform 2 [Homo sapiens]
         (835 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|51093830 bicaudal D homolog 1 isoform 2 [Homo sapiens]            1608   0.0  
gi|51039802 bicaudal D homolog 1 isoform 1 [Homo sapiens]            1579   0.0  
gi|51479166 bicaudal D homolog 2 isoform 1 [Homo sapiens]             974   0.0  
gi|21735417 bicaudal D homolog 2 isoform 2 [Homo sapiens]             973   0.0  
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]   103   5e-22
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   103   7e-22
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   103   7e-22
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   103   7e-22
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   103   7e-22
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        101   3e-21
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    100   7e-21
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    96   2e-19
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    93   9e-19
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    93   9e-19
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             91   3e-18
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     91   3e-18
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]                89   1e-17
gi|31542634 filamin A interacting protein 1 [Homo sapiens]             86   1e-16
gi|4506751 restin isoform a [Homo sapiens]                             86   2e-16
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    85   3e-16
gi|71061468 centromere protein E [Homo sapiens]                        84   4e-16
gi|9910266 kinesin family member 15 [Homo sapiens]                     84   4e-16
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       83   9e-16
gi|55770834 centromere protein F [Homo sapiens]                        82   2e-15
gi|38044112 restin isoform b [Homo sapiens]                            82   2e-15
gi|21735548 centrosomal protein 2 [Homo sapiens]                       81   5e-15
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]    80   6e-15
gi|34878904 synaptonemal complex protein 1 [Homo sapiens]              78   3e-14
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                  78   4e-14
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    77   5e-14

>gi|51093830 bicaudal D homolog 1 isoform 2 [Homo sapiens]
          Length = 835

 Score = 1608 bits (4165), Expect = 0.0
 Identities = 835/835 (100%), Positives = 835/835 (100%)

Query: 1   MAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYD 60
           MAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYD
Sbjct: 1   MAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYD 60

Query: 61  SLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSR 120
           SLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSR
Sbjct: 61  SLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSR 120

Query: 121 AVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENI 180
           AVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENI
Sbjct: 121 AVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENI 180

Query: 181 TLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKN 240
           TLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKN
Sbjct: 181 TLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKN 240

Query: 241 EREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDY 300
           EREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDY
Sbjct: 241 EREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDY 300

Query: 301 RTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGA 360
           RTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGA
Sbjct: 301 RTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGA 360

Query: 361 LTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKY 420
           LTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKY
Sbjct: 361 LTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKY 420

Query: 421 RVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKM 480
           RVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKM
Sbjct: 421 RVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKM 480

Query: 481 AHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQ 540
           AHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQ
Sbjct: 481 AHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQ 540

Query: 541 SRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTI 600
           SRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTI
Sbjct: 541 SRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTI 600

Query: 601 SPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELA 660
           SPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELA
Sbjct: 601 SPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELA 660

Query: 661 PMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMV 720
           PMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMV
Sbjct: 661 PMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMV 720

Query: 721 TETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLL 780
           TETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLL
Sbjct: 721 TETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLL 780

Query: 781 RMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKIVSSLLPPYRHSAHN 835
           RMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKIVSSLLPPYRHSAHN
Sbjct: 781 RMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKIVSSLLPPYRHSAHN 835


>gi|51039802 bicaudal D homolog 1 isoform 1 [Homo sapiens]
          Length = 975

 Score = 1579 bits (4088), Expect = 0.0
 Identities = 820/821 (99%), Positives = 821/821 (100%)

Query: 1   MAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYD 60
           MAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYD
Sbjct: 1   MAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYD 60

Query: 61  SLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSR 120
           SLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSR
Sbjct: 61  SLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSR 120

Query: 121 AVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENI 180
           AVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENI
Sbjct: 121 AVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENI 180

Query: 181 TLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKN 240
           TLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKN
Sbjct: 181 TLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKN 240

Query: 241 EREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDY 300
           EREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDY
Sbjct: 241 EREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDY 300

Query: 301 RTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGA 360
           RTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGA
Sbjct: 301 RTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGA 360

Query: 361 LTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKY 420
           LTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKY
Sbjct: 361 LTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKY 420

Query: 421 RVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKM 480
           RVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKM
Sbjct: 421 RVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKM 480

Query: 481 AHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQ 540
           AHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQ
Sbjct: 481 AHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQ 540

Query: 541 SRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTI 600
           SRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTI
Sbjct: 541 SRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTI 600

Query: 601 SPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELA 660
           SPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELA
Sbjct: 601 SPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELA 660

Query: 661 PMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMV 720
           PMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMV
Sbjct: 661 PMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMV 720

Query: 721 TETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLL 780
           TETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLL
Sbjct: 721 TETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLL 780

Query: 781 RMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKI 821
           RMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPK+
Sbjct: 781 RMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKV 821


>gi|51479166 bicaudal D homolog 2 isoform 1 [Homo sapiens]
          Length = 855

 Score =  974 bits (2517), Expect = 0.0
 Identities = 528/824 (64%), Positives = 638/824 (77%), Gaps = 38/824 (4%)

Query: 14  KTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAF 73
           + E++RL+ EL ETT EKIQAAEYGL VLEEK  LK Q++ELE +Y++++ E+EQLKEAF
Sbjct: 23  RAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAF 82

Query: 74  GQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERL 133
           GQ+ + H+KVA DGE+REE+L+QESASKE YY+ K+LE+Q ELKQ R V+TN Q+ENERL
Sbjct: 83  GQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERL 142

Query: 134 TAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQ 193
            +V Q+LKE N+ VE+QR R++D+I+EYKFREARLLQDY+ELEEENI+LQK VS L+QNQ
Sbjct: 143 ASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQ 202

Query: 194 VEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELS 253
           VE+EGLKHEIKR EEET  LNSQLEDAIRLKEI+E QLEEALETLK EREQKN+LRKELS
Sbjct: 203 VEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELS 262

Query: 254 QYISLND----NHISISVDGLKFAEDGSEPNNDDK--MNGHIHGPLVKLNGDYRTPTLRK 307
            Y+S+ND    +H+ +S+DGLKF++D +EPNND +  +NG  HG L KL  D +T T +K
Sbjct: 263 HYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKK 322

Query: 308 GESLNP-----VSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALT 362
            E L P     VSDL SELNISEIQKLKQQLMQ+EREKA LLA LQ++Q QLEHT+G+L+
Sbjct: 323 -EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLS 381

Query: 363 EQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRV 422
           EQ E+V RLTE+++A+R LQ+SKE +  LD EK RDS E+   YEVDING EIL CKY V
Sbjct: 382 EQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHV 441

Query: 423 AVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAH 482
           AV E  +L+ ++KAL+  +      + +EK +YE++ Q   E+V+ LEK +++  E +A 
Sbjct: 442 AVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLAR 501

Query: 483 MEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSR 542
           +EKEL+K++ +A E   +L+ AQDELVTFSEELA LYHHVC+CNNETPNRVMLDYYR+ +
Sbjct: 502 LEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQ 561

Query: 543 ----VTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTP 598
                T  G    P + RG  SP L  +G+ +P   R          +  S  PSP    
Sbjct: 562 GGAGRTSPGGRTSP-EARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP---- 616

Query: 599 TISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARE 658
                            SD R+EPMNIYNL AIIRDQIKHLQ AVDR+ +LSRQR A++E
Sbjct: 617 ----------------LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660

Query: 659 LAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKA 718
           L P +DKDKEALMEEILKLKSLLSTKREQI TLR VLKANKQTAEVALANLK+KYENEKA
Sbjct: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720

Query: 719 MVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNT 778
           MVTETM KLRNELKALKEDAATFSSLRAMFATRCDEY+TQLDEMQRQLAAAEDEKKTLN+
Sbjct: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780

Query: 779 LLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLG-KSKIGSPKI 821
           LLRMAIQQKLALTQRLE LE DHEQ+RR + K   K+K  +P +
Sbjct: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSV 824


>gi|21735417 bicaudal D homolog 2 isoform 2 [Homo sapiens]
          Length = 824

 Score =  973 bits (2516), Expect = 0.0
 Identities = 528/824 (64%), Positives = 638/824 (77%), Gaps = 38/824 (4%)

Query: 14  KTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAF 73
           + E++RL+ EL ETT EKIQAAEYGL VLEEK  LK Q++ELE +Y++++ E+EQLKEAF
Sbjct: 23  RAEVKRLSHELAETTREKIQAAEYGLAVLEEKHQLKLQFEELEVDYEAIRSEMEQLKEAF 82

Query: 74  GQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERL 133
           GQ+ + H+KVA DGE+REE+L+QESASKE YY+ K+LE+Q ELKQ R V+TN Q+ENERL
Sbjct: 83  GQAHTNHKKVAADGESREESLIQESASKEQYYVRKVLELQTELKQLRNVLTNTQSENERL 142

Query: 134 TAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQ 193
            +V Q+LKE N+ VE+QR R++D+I+EYKFREARLLQDY+ELEEENI+LQK VS L+QNQ
Sbjct: 143 ASVAQELKEINQNVEIQRGRLRDDIKEYKFREARLLQDYSELEEENISLQKQVSVLRQNQ 202

Query: 194 VEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELS 253
           VE+EGLKHEIKR EEET  LNSQLEDAIRLKEI+E QLEEALETLK EREQKN+LRKELS
Sbjct: 203 VEFEGLKHEIKRLEEETEYLNSQLEDAIRLKEISERQLEEALETLKTEREQKNSLRKELS 262

Query: 254 QYISLND----NHISISVDGLKFAEDGSEPNNDDK--MNGHIHGPLVKLNGDYRTPTLRK 307
            Y+S+ND    +H+ +S+DGLKF++D +EPNND +  +NG  HG L KL  D +T T +K
Sbjct: 263 HYMSINDSFYTSHLHVSLDGLKFSDDAAEPNNDAEALVNGFEHGGLAKLPLDNKTSTPKK 322

Query: 308 GESLNP-----VSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALT 362
            E L P     VSDL SELNISEIQKLKQQLMQ+EREKA LLA LQ++Q QLEHT+G+L+
Sbjct: 323 -EGLAPPSPSLVSDLLSELNISEIQKLKQQLMQMEREKAGLLATLQDTQKQLEHTRGSLS 381

Query: 363 EQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRV 422
           EQ E+V RLTE+++A+R LQ+SKE +  LD EK RDS E+   YEVDING EIL CKY V
Sbjct: 382 EQQEKVTRLTENLSALRRLQASKERQTALDNEKDRDSHEDGDYYEVDINGPEILACKYHV 441

Query: 423 AVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAH 482
           AV E  +L+ ++KAL+  +      + +EK +YE++ Q   E+V+ LEK +++  E +A 
Sbjct: 442 AVAEAGELREQLKALRSTHEAREAQHAEEKGRYEAEGQALTEKVSLLEKASRQDRELLAR 501

Query: 483 MEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSR 542
           +EKEL+K++ +A E   +L+ AQDELVTFSEELA LYHHVC+CNNETPNRVMLDYYR+ +
Sbjct: 502 LEKELKKVSDVAGETQGSLSVAQDELVTFSEELANLYHHVCMCNNETPNRVMLDYYREGQ 561

Query: 543 ----VTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTP 598
                T  G    P + RG  SP L  +G+ +P   R          +  S  PSP    
Sbjct: 562 GGAGRTSPGGRTSP-EARGRRSPILLPKGLLAPEAGRADGGTGDSSPSPGSSLPSP---- 616

Query: 599 TISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARE 658
                            SD R+EPMNIYNL AIIRDQIKHLQ AVDR+ +LSRQR A++E
Sbjct: 617 ----------------LSDPRREPMNIYNLIAIIRDQIKHLQAAVDRTTELSRQRIASQE 660

Query: 659 LAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKA 718
           L P +DKDKEALMEEILKLKSLLSTKREQI TLR VLKANKQTAEVALANLK+KYENEKA
Sbjct: 661 LGPAVDKDKEALMEEILKLKSLLSTKREQITTLRTVLKANKQTAEVALANLKSKYENEKA 720

Query: 719 MVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNT 778
           MVTETM KLRNELKALKEDAATFSSLRAMFATRCDEY+TQLDEMQRQLAAAEDEKKTLN+
Sbjct: 721 MVTETMMKLRNELKALKEDAATFSSLRAMFATRCDEYITQLDEMQRQLAAAEDEKKTLNS 780

Query: 779 LLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLG-KSKIGSPKI 821
           LLRMAIQQKLALTQRLE LE DHEQ+RR + K   K+K  +P +
Sbjct: 781 LLRMAIQQKLALTQRLELLELDHEQTRRGRAKAAPKTKPATPSL 824


>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
          Length = 1684

 Score =  103 bits (258), Expect = 5e-22
 Identities = 187/880 (21%), Positives = 348/880 (39%), Gaps = 87/880 (9%)

Query: 5    EVLQT-----VDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEY 59
            E+LQT           E E + ++     HE  Q          EK  L +  + L+ E 
Sbjct: 488  EILQTELGESAGKISQEFESMKQQQASDVHELQQKLR---TAFTEKDALLETVNRLQGEN 544

Query: 60   DSLKQELEQLKEAFGQSFSIHRK--VAEDGETREETLLQESASKEAYYLGKILEMQNELK 117
            + L  + E + E      ++  K  V     ++ +T+L+E   K      +  +  N+LK
Sbjct: 545  EKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLK 604

Query: 118  QSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEE 177
             S   + N   + ER   ++ +L +  E        ++ ++ E       L +   E ++
Sbjct: 605  NSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELT---GGLEETLKEKDQ 661

Query: 178  ENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQ-------LEDAIRLKE---IA 227
             +  L+KL+  +K    + E L  E+K   EE   L+S+       LE  +  KE   + 
Sbjct: 662  NDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILK 721

Query: 228  EH--QLEEALETLKNEREQKNNL--RKELSQYISLNDNHISISVDGLKFAEDGSEPNNDD 283
            EH  QLE+ L+ +  E++  N L   +++ +       +  +   G + +ED  E +  +
Sbjct: 722  EHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVN 781

Query: 284  KMNGHIHGPLVKLNGDYRTPTLRKGES---LNPVSDLFSELNISEIQKLKQQLMQVEREK 340
             +   +   L K+N +      ++ E    L        E ++ + ++LK  L   E+EK
Sbjct: 782  VLQA-VGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840

Query: 341  AILLANLQESQTQLEHTKGALTEQHERVHRLT-EHVNAMRGLQSSKEL--KAELDGEKGR 397
             +L   L+E Q++ E  +  L E      +   E+ N +  ++   +   K+E+  EK +
Sbjct: 841  VLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEK 900

Query: 398  DSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYES 457
               +E  + +       +LE K      E+ D +AE+  LK+   KS     D      S
Sbjct: 901  CFIKEHENLK------PLLEQK------ELRDRRAELILLKDSLAKSPSVKNDPL----S 944

Query: 458  KIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQ 517
             ++  +E++ +LEK  KE  EK+  ++    K     + +     T ++EL +   E  Q
Sbjct: 945  SVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQ 1004

Query: 518  LYHHV--CLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETR 575
            L   +   +   E+   ++L+Y +QS        +  +    +       R  +   ET 
Sbjct: 1005 LSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064

Query: 576  TSSEPVAKESTEASKEPSPTKTPTISPVITAPPS-SPVLDTSDIRKEPM---------NI 625
             S         E  +  +      I  V  A       L+   ++KE            +
Sbjct: 1065 NSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNEL 1124

Query: 626  YNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKR 685
              L   ++ + K LQK + + L+L ++ A    L  M   D E LM+E   L   L+ K 
Sbjct: 1125 EELQVQLQKEKKQLQKTM-QELELVKKDAQQTTLMNMEIADYERLMKE---LNQKLTNKN 1180

Query: 686  EQIATLRAVLKANKQTAE------VALANLKNKYENEKAMVTETMTKLRNELKALKEDAA 739
             +I  L   +K  KQ  E       +L +   +YE +   + + + K + EL   K+   
Sbjct: 1181 NKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAET 1240

Query: 740  TFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQK----LALTQRLE 795
                L+A      +    Q++  + QLA    EK  ++  L+ + +Q      A  QR+ 
Sbjct: 1241 DHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVT 1300

Query: 796  DLEFDHEQSRRSKGKLGKSKIGSPKIVSSLLPPYRHSAHN 835
             L+   E+ R +K +           V+S    Y+   HN
Sbjct: 1301 ALQ---EECRAAKAE--------QATVTSEFESYKVRVHN 1329



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 166/855 (19%), Positives = 334/855 (39%), Gaps = 139/855 (16%)

Query: 17  IERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQ-----------YDELE-------AE 58
           I+ LT+ L     EK +  +  L + +E + +KQ+           + ELE        E
Sbjct: 71  IKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKE 130

Query: 59  YDSLKQEL---------------EQLKEAFGQSFSIHR--KVAEDGETREETLLQESASK 101
            ++LK EL               +QL+EA      +    K   + E   + L +E    
Sbjct: 131 IENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKI 190

Query: 102 EAYYLGKILEMQNEL----KQSRAVVTNVQ----AENERLTAVVQDLKENNEMVELQRIR 153
              +  +IL +Q +L     + +  VT +Q    A ++     +  L+E  E+++L+ I 
Sbjct: 191 RPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQE--ELLQLKAIH 248

Query: 154 MKDEIREYKFR-EARLLQDYTELEEENITLQKLV--------STLKQNQVEYEGLKHEIK 204
            ++E++E   + EA   +   E+ + N   + LV        +  K+ + E E L+    
Sbjct: 249 -QEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATS 307

Query: 205 RFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHIS 264
              ++  + +  L++   ++++   +++   +TLK    Q + L+ E++    +N+  + 
Sbjct: 308 NANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTY---MNNLKLK 364

Query: 265 ISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGE--SLNPVSDLFSELN 322
           + +D     ++      D  +   I+  L+            K E   LN       E +
Sbjct: 365 LEMDAQHIKDEFFHERED--LEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQH 422

Query: 323 ISEIQKLKQQ-LMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGL 381
             E+Q LK+Q   ++       L++ ++ +  L      L EQ E + +  E   A+   
Sbjct: 423 NREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQ--EKQEAILNY 480

Query: 382 QSSKELKAELDGEKGRDSGEEAHDYE----VDINGLEILECKYRVAVTEVIDLKAEIKAL 437
           +S +E+   L  E G  +G+ + ++E       + +  L+ K R A TE           
Sbjct: 481 ESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTE----------- 529

Query: 438 KEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANEN 497
           K+   ++V     E  K  S+     E V  LE T K   EK       L +  ++  E 
Sbjct: 530 KDALLETVNRLQGENEKLLSQ----QELVPELENTIKNLQEKNGVYLLSLSQRDTMLKEL 585

Query: 498 HSTLNTAQDELVTF------SEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKG 551
              +N+  +E   F      S E    +H  C    E   R++L+  ++   T       
Sbjct: 586 EGKINSLTEEKDDFINKLKNSHEEMDNFHKKC----EREERLILELGKKVEQTIQ----- 636

Query: 552 PDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSP 611
                            +S +E + +      E T   K+ +  K   +   +       
Sbjct: 637 ----------------YNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSE-- 678

Query: 612 VLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALM 671
             D   +  E  ++Y  N  +  + K L + ++  L   ++    +E    ++K  + ++
Sbjct: 679 --DKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLS-QKEDVILKEHITQLEKKLQLMV 735

Query: 672 EEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNEL 731
           EE   L  LL  ++ Q    +  +K         + +  ++   EK +V        N L
Sbjct: 736 EEQDNLNKLLENEQVQ----KLFVKTQLYGFLKEMGSEVSEDSEEKDVV--------NVL 783

Query: 732 KALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEK----KTLNTLLRMAIQQK 787
           +A+ E  A  +  +   A + DE V    E+++++   ++E     + L +LLR   Q+K
Sbjct: 784 QAVGESLAKINEEKCNLAFQRDEKVL---ELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840

Query: 788 LALTQRLEDLEFDHE 802
           + L + LE+++ + E
Sbjct: 841 VLLRKELEEIQSEKE 855



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 169/857 (19%), Positives = 345/857 (40%), Gaps = 96/857 (11%)

Query: 4    EEVLQTVDHYKTEIERLTKELT----ETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEY 59
            ++V QT+  Y +E+E+   ELT    ET  EK Q  +    ++ +   L +  + L AE 
Sbjct: 629  KKVEQTIQ-YNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEV 687

Query: 60   DSLKQELEQL---KEAFGQSFSIHRKVAEDGETREE-TLLQESAS---KEAYYLGKILEM 112
             SL +E  +L   K+   +   +     ED   +E  T L++      +E   L K+LE 
Sbjct: 688  KSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE- 746

Query: 113  QNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVE-LQRI-RMKDEIREYKFREARLLQ 170
             NE  Q   V T +    + + + V +  E  ++V  LQ +     +I E K   A    
Sbjct: 747  -NEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLA---- 801

Query: 171  DYTELEEENITLQKLVSTLKQNQV-EYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEH 229
               + +E+ + L+K +  L++  V + E LK  ++ +E+E VLL  +LE+    KE  + 
Sbjct: 802  --FQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQS 859

Query: 230  QLEEALETLKNEREQKNNLR---KELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMN 286
             L E     +  R +  NL    +E+SQ  S ++ H       +K   +  +P  + K  
Sbjct: 860  DLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIK-EHENLKPLLEQKEL 918

Query: 287  GHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISE---------IQKLKQQLMQVE 337
                  L+ L          K + L+ V +L  ++   E         I K+K   ++ +
Sbjct: 919  RDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAK 978

Query: 338  REKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAE------- 390
            +E   L ++ +E+QT  E  +   +E+ +    + +    ++G +S K L  E       
Sbjct: 979  KE---LDSSRKETQTVKEELESLRSEKDQLSASMRD---LIQGAESYKNLLLEYEKQSEQ 1032

Query: 391  LDGEKGRDSGEEAH--------------------DYEVDINGLEILECKYRVAVTEVIDL 430
            LD EK R +  E                      D E  +  +E L+   ++   +++  
Sbjct: 1033 LDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQIL-- 1090

Query: 431  KAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKM 490
              E++  K   +K +E    EK + E KI+ +   V  LE+   +  ++   ++K +Q++
Sbjct: 1091 --EVQRAKAMVDKELE---AEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQEL 1145

Query: 491  TSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLK 550
              +  +   T      E+  +   + +L   +   NN+     + D  ++ ++ +     
Sbjct: 1146 ELVKKDAQQT-TLMNMEIADYERLMKELNQKLTNKNNK-----IEDLEQEIKIQKQKQET 1199

Query: 551  GPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSS 610
              ++   L          SS  +    +  + +   +  KE + +K      +I      
Sbjct: 1200 LQEEITSL---------QSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLK 1250

Query: 611  PVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEAL 670
              L+ S  + E   I  L  I  ++ K  +     + Q  R  +A ++    + ++  A 
Sbjct: 1251 GELEASQQQVEVYKI-QLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAA 1309

Query: 671  MEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNE 730
              E   + S   + + ++  +    K NK  ++      K + E+ + ++ +   KL++ 
Sbjct: 1310 KAEQATVTSEFESYKVRVHNVLKQQK-NKSMSQAETEGAKQEREHLEMLIDQLKIKLQDS 1368

Query: 731  LKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLAL 790
               L+ + +   +L++   T  + +   L   Q  ++   + ++ L ++    +  K   
Sbjct: 1369 QNNLQINVSELQTLQSEHDTLLERHNKML---QETVSKEAELREKLCSIQSENMMMKSEH 1425

Query: 791  TQRLEDLEFDHEQSRRS 807
            TQ +  L   +E  R S
Sbjct: 1426 TQTVSQLTSQNEVLRNS 1442



 Score = 70.1 bits (170), Expect = 8e-12
 Identities = 152/773 (19%), Positives = 309/773 (39%), Gaps = 108/773 (13%)

Query: 17   IERLTKELTETTHEK-----IQAAEYGLVVL-EEKLTLKQQYDELEAEYDSLKQELEQLK 70
            ++ +  E++E + EK     +QA    L  + EEK  L  Q DE   E   L++E++ L+
Sbjct: 763  LKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLE---LEKEIKCLQ 819

Query: 71   EAFGQSFSIHRKVAEDGETREETL---LQESASKEAYYLGKILEMQNELKQSRAVVTNVQ 127
            E         + +  D E  +  L   L+E  S++      +LEM+N  +++R    N+ 
Sbjct: 820  EESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLL 879

Query: 128  AENERLTAVVQDLKENNE-----MVELQRIRMKDEIREYKFREARLLQDYTELEEENITL 182
             + E ++      + +NE     + E + ++   E +E + R A L+     L +     
Sbjct: 880  IQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVK 939

Query: 183  QKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQ------LEEALE 236
               +S++K+ + + E L+ E K  EE+   +N     A++ K+  +        ++E LE
Sbjct: 940  NDPLSSVKELEEKIENLEKECKEKEEK---INKIKLVAVKAKKELDSSRKETQTVKEELE 996

Query: 237  TLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKL 296
            +L++E++Q +   ++L Q      N +      L++ +   + + + +   +    +  L
Sbjct: 997  SLRSEKDQLSASMRDLIQGAESYKNLL------LEYEKQSEQLDVEKERANNFEHRIEDL 1050

Query: 297  NGDYRTPTLRKGESLNPVSDLFSELNI--SEIQKLKQQLMQVEREKAIL-----LANLQE 349
                R  TL+     +   DL + +    S  + L+ Q+++V+R KA++        LQ+
Sbjct: 1051 TRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK 1110

Query: 350  SQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVD 409
             Q   EH       +  +V    E     + +Q  + +K   D ++      E  DYE  
Sbjct: 1111 EQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKK--DAQQTTLMNMEIADYE-- 1166

Query: 410  INGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSL 469
               ++ L  K      ++ DL+ EIK  K+K     E   +E    +S +Q Y+E+ T +
Sbjct: 1167 -RLMKELNQKLTNKNNKIEDLEQEIKIQKQKQ----ETLQEEITSLQSSVQQYEEKNTKI 1221

Query: 470  E----KTTKESGEK----------MAHMEKELQ-----------KMTSIANENHS----- 499
            +    KT KE  +            A ++ EL+           ++  I +E H      
Sbjct: 1222 KQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHL 1281

Query: 500  ---------TLNTAQDELVTFSEELAQLYHHVCLCNNETPN-RVMLDYYRQSRVTRSGS- 548
                     TL+  Q  +    EE            +E  + +V +    + +  +S S 
Sbjct: 1282 KTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQ 1341

Query: 549  --LKGPDDPRGLLSPRLARRGVS------------SPVETRTSSEPVAKESTEASKEPSP 594
               +G    R  L   + +  +             S ++T  S      E      + + 
Sbjct: 1342 AETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETV 1401

Query: 595  TKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIR----DQIKHLQKAVDRSLQLS 650
            +K   +   + +  S  ++  S+  +    + + N ++R    DQ++HLQ+   ++++  
Sbjct: 1402 SKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETL 1461

Query: 651  RQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAE 703
            +Q+ +  E A +     E      +  +  L   RE+  T   +L  +  T E
Sbjct: 1462 QQQLSKME-AQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE 1513



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 99/506 (19%), Positives = 202/506 (39%), Gaps = 76/506 (15%)

Query: 22   KELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHR 81
            KEL     +K Q  +     + E   L+ Q  + + +     QELE +K+   Q+  ++ 
Sbjct: 1101 KELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNM 1160

Query: 82   KVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLK 141
            ++A+      E L++E   K      KI +++ E+K  +     +Q E   L + VQ  +
Sbjct: 1161 EIAD-----YERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYE 1215

Query: 142  ENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKH 201
            E N  ++   ++ K E           L D  + E +++ LQ               LK 
Sbjct: 1216 EKNTKIKQLLVKTKKE-----------LADSKQAETDHLILQ-------------ASLKG 1251

Query: 202  EIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDN 261
            E++  +++  +   QL +    K    H++ E L+T     EQ         Q ++    
Sbjct: 1252 ELEASQQQVEVYKIQLAEITSEK----HKIHEHLKT---SAEQHQRTLSAYQQRVTALQE 1304

Query: 262  HISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSEL 321
                +      AE  +  +  +     +H  L +          +K +S++      ++ 
Sbjct: 1305 ECRAAK-----AEQATVTSEFESYKVRVHNVLKQ----------QKNKSMSQAETEGAKQ 1349

Query: 322  NISEIQKLKQQL-MQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRG 380
                ++ L  QL ++++  +  L  N+ E QT L+     L E+H ++  L E V+    
Sbjct: 1350 EREHLEMLIDQLKIKLQDSQNNLQINVSELQT-LQSEHDTLLERHNKM--LQETVSKEAE 1406

Query: 381  LQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEK 440
            L   +E    +  E      E         +  E+L   +R           +++ L+E+
Sbjct: 1407 L---REKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFR----------DQVRHLQEE 1453

Query: 441  YNKSVENYTDEKAKYESKI-QMYDEQVTSLEKTTKESGEKM---AHMEKELQKMTSIANE 496
            + K+VE    + +K E+++ Q+ +E  T    ++++S + +    + +  L  M ++  E
Sbjct: 1454 HRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE 1513

Query: 497  NHSTLNTAQDELV----TFSEELAQL 518
                + T   E V    T+++ L QL
Sbjct: 1514 EGEGMETTDTESVSSASTYTQSLEQL 1539



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 83/409 (20%), Positives = 169/409 (41%), Gaps = 91/409 (22%)

Query: 158 IREYKFREARLLQDYTELEEENIT------LQKLVSTLKQNQVEYEGLKHEIKRFEEETV 211
           I++ K R   L ++  EL  + +T      ++ L   L    +E    + +    ++E +
Sbjct: 41  IQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENI 100

Query: 212 LLNSQLEDAIRLKEIAEHQLEEA-------LETLKNE--------REQKNNLRKELSQYI 256
            +  ++ED++     A  +LE++       +E LKNE         E K NL+K+L + +
Sbjct: 101 KMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAM 160

Query: 257 SLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSD 316
           +     + +S + LKF     + N++D +                    +  E +  +  
Sbjct: 161 N---TQLELS-EQLKF-----QNNSEDNVK-------------------KLQEEIEKIRP 192

Query: 317 LFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHER-VHRLTEHV 375
            F E    +I  L++QL     EK       +E+ TQL++   A ++ +++ ++ L E +
Sbjct: 193 GFEE----QILYLQKQLDATTDEK-------KETVTQLQNIIEANSQHYQKNINSLQEEL 241

Query: 376 NAMRGLQSS--KELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAE 433
             ++ +     KEL  +++          A ++E +IN L  L+         V   +A 
Sbjct: 242 LQLKAIHQEEVKELMCQIEAS--------AKEHEAEINKLNELKENL------VKQCEAS 287

Query: 434 IKALKEKYNKSVENY--TDEKAKYESKI------------QMYDEQVTSLEKTTKESGEK 479
            K +++KY   +EN       A  +++I            Q+ +E+V  LE T KE   +
Sbjct: 288 EKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQ 347

Query: 480 MAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNE 528
            + ++ E+  M ++  +        +DE     E+L    + + L   E
Sbjct: 348 HSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEE 396


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  103 bits (257), Expect = 7e-22
 Identities = 170/831 (20%), Positives = 335/831 (40%), Gaps = 146/831 (17%)

Query: 46   LTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYY 105
            L + +Q +E++A+ D L++  E+ ++A  +   + +K ++   T E+ LLQE    E   
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ--LTEEKNLLQEQLQAETEL 902

Query: 106  LGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFRE 165
              +  EM+  L   +  +  +  E E   A +++ ++  + ++ +R +M  ++ + +   
Sbjct: 903  YAEAEEMRVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKKMAQQMLDLE--- 956

Query: 166  ARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKE 225
                    +LEEE    QKL       Q+E    + +IK+ E+E ++++ Q     + ++
Sbjct: 957  -------EQLEEEEAARQKL-------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002

Query: 226  IAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKM 285
            + E ++ +    L  E E+  NL K       L + H S+       +E       ++K 
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTK-------LKNKHESM------ISELEVRLKKEEKS 1049

Query: 286  NGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLA 345
               +     KL GD         +    ++DL ++     I +LK QL + E E    LA
Sbjct: 1050 RQELEKLKRKLEGD-------ASDFHEQIADLQAQ-----IAELKMQLAKKEEELQAALA 1097

Query: 346  NLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHD 405
             L +   Q  +    + E    +  L E +++ R  ++  E       ++ RD GEE   
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE-------KQKRDLGEELEA 1150

Query: 406  YEVDINGL-------EILECKYRVAVT--------EVIDLKAEIKALKEKYNKSVENYTD 450
             + ++          + L  K    VT        E    +A+++ +++K+ ++VE  T+
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210

Query: 451  EKAKYESKIQMYDEQVTSLEKTTKE----------SGEKMAHMEKELQKMTSIANENHST 500
            +  +++      D+   +LEK   +          + +++ H +K+L+          S 
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270

Query: 501  LNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLS 560
               A+ EL     +L      V    NE   + +    + ++   S S +  D    L  
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAI----KLAKDVASLSSQLQDTQELLQE 1326

Query: 561  PRLARRGVSSPV----ETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTS 616
                +  VS+ +    E R S +    E  EA +             +    S+  +  S
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN------------LERHISTLNIQLS 1374

Query: 617  DIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILK 676
            D +K+  +  +    + +  K  QK ++   Q   ++AAA +    ++K K  L +E+  
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD---KLEKTKNRLQQELDD 1431

Query: 677  LKSLLSTKREQIATL-RAVLKANKQTAEVALANLKNKYENEK----AMVTETMTK----- 726
            L   L  +R+ ++ L +   K ++  AE    N+ +KY +E+    A   E  TK     
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEK--NISSKYADERDRAEAEAREKETKALSLA 1489

Query: 727  --LRNELKALKEDAATFSSLRA------------------------MFATRCDEYVTQLD 760
              L   L+A +E   T   L+A                           T+ +E  TQL+
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549

Query: 761  EMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKL 811
            E++ +L A ED K      LR+ +  +    Q   DL+   EQ+   + +L
Sbjct: 1550 ELEDELQATEDAK------LRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 173/827 (20%), Positives = 329/827 (39%), Gaps = 148/827 (17%)

Query: 16   EIERLTKELTETT--HE-KIQAAEYGLVVLEEKLTLK-QQYDELEAEYDSLKQELEQLKE 71
            E+  L K L E T  HE ++Q          E+LT + +Q+   +A  D  KQ LE+   
Sbjct: 1175 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234

Query: 72   AFGQSFSIHRKVAEDGETREETL---LQESASK-------EAYYLGKILEMQNELKQSRA 121
                   +  +  ++ E +++ L   +QE  SK        A    K+ ++QNE++    
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294

Query: 122  VVTNVQAENERL-------TAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTE 174
            ++   + +  +L       ++ +QD +E  +    Q++ +  ++R+ +  E   LQD  +
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE-EERNSLQDQLD 1353

Query: 175  LEEE------------NITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAI- 221
             E E            NI L      L+      E L+   KRF++E   L  Q E+   
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413

Query: 222  ------RLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAE- 274
                  + K   + +L++ +  L N+R+  +NL K+  ++  L     +IS    K+A+ 
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS---KYADE 1470

Query: 275  -DGSEPNNDDK------MNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQ 327
             D +E    +K      +   +   L       RT  + K E    + DL     +S   
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE----MEDL-----VSSKD 1521

Query: 328  KLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKEL 387
             + + + ++E+ K  L   ++E +TQLE  +  L    +   RL  ++ A++G Q  ++L
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG-QFERDL 1580

Query: 388  KA--ELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSV 445
            +A  E + EK R    + H+YE                 TE+ D + + +AL     K +
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYE-----------------TELEDERKQ-RALAAAAKKKL 1622

Query: 446  E-NYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTA 504
            E +  D + + +S I+  +E +  L K   +    M   ++EL+   +  +E  +T    
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQ----MKDFQRELEDARASRDEIFATAKEN 1678

Query: 505  QDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLA 564
            + +  +   +L QL                 D     R  +   L+  +    L S    
Sbjct: 1679 EKKAKSLEADLMQLQE---------------DLAAAERARKQADLEKEELAEELASSLSG 1723

Query: 565  RRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMN 624
            R  +    E R     +A+   E  +E                                 
Sbjct: 1724 RNALQD--EKRRLEARIAQLEEELEEEQG------------------------------- 1750

Query: 625  IYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTK 684
              N+ A+  D+++   KA  ++ QLS + A  R  A   +  ++ L  +  +L+S L   
Sbjct: 1751 --NMEAM-SDRVR---KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL--- 1801

Query: 685  REQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSL 744
             E    +++  K+     E  +A L+ + E E          L+ + K LKE        
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861

Query: 745  RAM---FATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKL 788
            R M   +  + ++   ++ +++RQL  AE+E + +N   R  +Q++L
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA-NRRKLQREL 1907



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 179/905 (19%), Positives = 368/905 (40%), Gaps = 167/905 (18%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTH---EKIQAAEYGLVVLEE-KLTLKQQYDELEAEY 59
            +E  Q  ++   E+E+   +LTE  +   E++QA        EE ++ L  +  ELE   
Sbjct: 865  KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 924

Query: 60   DSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKIL--------- 110
              ++  LE+ ++   Q  +  +K+A+     EE L +E A+++   L K+          
Sbjct: 925  HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 984

Query: 111  -------EMQNELKQSRAVV--------TNVQAENERLTAVVQDLKENNEMVELQRIRMK 155
                   +  N+L + R ++        TN+  E E+   + +   ++  M+    +R+K
Sbjct: 985  DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044

Query: 156  DEIR---EYKFREARLLQDYTELEEENITLQKLVSTLK-QNQVEYEGLKHEIKRFEEETV 211
             E +   E +  + +L  D ++  E+   LQ  ++ LK Q   + E L+  + R ++E  
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1104

Query: 212  LLNSQLEDAIRLKEIAEH--QLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDG 269
              N+ L+   +++E+  H   L+E L++ +  R +    +++L + +      +  ++D 
Sbjct: 1105 QKNNALK---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1161

Query: 270  -----------------LKFAEDGSEPNNDDKMNG--HIHGPLV-------------KLN 297
                             LK A D    +++ ++      H   V             K N
Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN 1221

Query: 298  GDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHT 357
             D    TL K  +     DL  EL +     L Q   +VE +K  L A +QE Q++    
Sbjct: 1222 LDKNKQTLEKENA-----DLAGELRV-----LGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271

Query: 358  KGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILE 417
            + A  E +++VH+L   V ++ G+ +  E KA    +       +  D +      E+L+
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ------ELLQ 1325

Query: 418  CKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESG 477
             + R    + +++  +++ L+E+ N S+++  DE+ + +  ++ +   +++L     +S 
Sbjct: 1326 EETR----QKLNVSTKLRQLEEERN-SLQDQLDEEMEAKQNLERH---ISTLNIQLSDSK 1377

Query: 478  EKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDY 537
            +K+      ++ +     E         + L    EE A  Y  +     +T NR+  + 
Sbjct: 1378 KKLQDFASTVEAL----EEGKKRFQKEIENLTQQYEEKAAAYDKL----EKTKNRLQQEL 1429

Query: 538  YRQSRVTRSGSLKGPDDPRGLLS--PRLARRGVSSPVETRTSSEPVAKESTEASKEPSPT 595
                       +   D+ R L+S   +  R+      E +  S   A E   A  E    
Sbjct: 1430 --------DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481

Query: 596  KTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAA 655
            +T  +S        +  L+ +   KE +     N +++ +++ L  + D           
Sbjct: 1482 ETKALS-------LARALEEALEAKEELE--RTNKMLKAEMEDLVSSKD----------D 1522

Query: 656  ARELAPMIDKDKEALMEEILKLKSLLSTKREQI-ATLRAVLKANKQTAEVALANLKNKYE 714
              +    ++K K AL  ++ ++K+ L    +++ AT  A L+      EV +  LK ++E
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-----LEVNMQALKGQFE 1577

Query: 715  NEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKK 774
             +     E   + R +L+                  +  EY T+L++ ++Q A A   KK
Sbjct: 1578 RDLQARDEQNEEKRRQLQ-----------------RQLHEYETELEDERKQRALAAAAKK 1620

Query: 775  TLNTLLR--------------MAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPK 820
             L   L+               AI+Q   L  +++D + + E +R S+ ++  +   + K
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680

Query: 821  IVSSL 825
               SL
Sbjct: 1681 KAKSL 1685



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 189/888 (21%), Positives = 342/888 (38%), Gaps = 143/888 (16%)

Query: 7    LQTVDHYKTEIERLTKEL---TETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLK 63
            L+  +  + E+E+L ++L       HE+I  A+    + E K+ L ++ +EL+A    L 
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQI--ADLQAQIAELKMQLAKKEEELQAALARLD 1100

Query: 64   QELEQLKEAFGQSFSIHRKVAEDGETRE-ETLLQESASKEAYYLGKILE-MQNELKQ--- 118
             E+ Q   A  +   +   +++  E  + E   +  A K+   LG+ LE ++ EL+    
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160

Query: 119  SRAVVTNVQAENERLTAVVQ---DLKENNEMVELQRIRMK---------DEIREYKFREA 166
            S A    ++A+ E+   V++   D +  +   ++Q +R K         +++ ++K  +A
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220

Query: 167  RLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLK-E 225
             L ++   LE+EN  L   +  L Q + E E   H+ K+ E +   L S+  D  R + E
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVE---HKKKKLEAQVQELQSKCSDGERARAE 1277

Query: 226  IAE--HQLEEALETLK---NEREQKN-NLRKELSQYIS-LNDN------------HISIS 266
            + +  H+L+  +E++    NE E K   L K+++   S L D             ++S  
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337

Query: 267  VDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISE- 325
            +  L+   +  +   D++M    +     L     T  ++  +S   + D  S +   E 
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQN-----LERHISTLNIQLSDSKKKLQDFASTVEALEE 1392

Query: 326  ----IQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRG- 380
                 QK  + L Q   EKA     L++++ +L+     L    +   +L  ++   +  
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1452

Query: 381  ----LQSSKELKAELDGEKGRDSGEEAHDYEVDINGL-----EILECKYRVAVTEVIDLK 431
                L   K + ++   E+ R   E A + E     L     E LE K  +  T  + LK
Sbjct: 1453 FDQLLAEEKNISSKYADERDRAEAE-AREKETKALSLARALEEALEAKEELERTNKM-LK 1510

Query: 432  AEIKAL---KEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQ 488
            AE++ L   K+   K+V      K   E++++    Q+  LE   + + +    +E  +Q
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570

Query: 489  KMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGS 548
               ++  +    L    ++      +L +  H       ET    + D  +Q  +  +  
Sbjct: 1571 ---ALKGQFERDLQARDEQNEEKRRQLQRQLHEY-----ETE---LEDERKQRALAAAAK 1619

Query: 549  LKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPP 608
             K   D + L                   ++   K   EA K+            + A  
Sbjct: 1620 KKLEGDLKDL----------------ELQADSAIKGREEAIKQLRK---------LQAQM 1654

Query: 609  SSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKE 668
                 +  D R     I+   A  ++  K  +      +QL    AAA       D +KE
Sbjct: 1655 KDFQRELEDARASRDEIF---ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711

Query: 669  ALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKA---------- 718
             L EE   L S LS         R  L+  K+  E  +A L+ + E E+           
Sbjct: 1712 ELAEE---LASSLSG--------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760

Query: 719  MVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNT 778
              T+   +L NEL   +  A    S R     +  E  ++L EM+   A     K T+  
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG--AVKSKFKSTI-- 1816

Query: 779  LLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKIVSSLL 826
                      AL  ++  LE   EQ  R K    KS     K +  +L
Sbjct: 1817 ---------AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 112/544 (20%), Positives = 214/544 (39%), Gaps = 85/544 (15%)

Query: 13   YKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ---ELEQL 69
            ++ EIE LT++  E      +AA Y  +  + K  L+Q+ D+L  + D+ +Q    LE+ 
Sbjct: 1397 FQKEIENLTQQYEE------KAAAYDKLE-KTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449

Query: 70   KEAFGQSFSIHRKVAE---DGETREETLLQESASKE---AYYLGKILEMQNELKQSRAVV 123
            +  F Q  +  + ++    D   R E   +E  +K    A  L + LE + EL+++  + 
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM- 1508

Query: 124  TNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQ 183
              ++AE E L +   D+ +N   +E  +  ++ ++ E K +   L  +    E+  + L+
Sbjct: 1509 --LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566

Query: 184  KLVSTLK------------QNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQL 231
              +  LK            QN+ +   L+ ++  +E E      Q   A   K+  E  L
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626

Query: 232  --------------EEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGS 277
                          EEA++ L+  + Q  + ++EL    +  D   + + +  K A+   
Sbjct: 1627 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS-- 1684

Query: 278  EPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVE 337
                       +   L++L  D     L   E     +DL  E    E+         ++
Sbjct: 1685 -----------LEADLMQLQED-----LAAAERARKQADLEKEELAEELASSLSGRNALQ 1728

Query: 338  REKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGR 397
             EK  L A + + + +LE  +G +    +RV + T         Q +++L  EL  E+  
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT---------QQAEQLSNELATERST 1779

Query: 398  DSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDE------ 451
                E+   +++    E+    + +        K+ I AL+ K  +  E    E      
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1839

Query: 452  -------KAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTA 504
                   K K   +I +  E    + +  KE  EK     K+L++    A E    +N  
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899

Query: 505  QDEL 508
            + +L
Sbjct: 1900 RRKL 1903



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 86/463 (18%), Positives = 195/463 (42%), Gaps = 38/463 (8%)

Query: 2    AAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDS 61
            A EE L+  +  +   + L  E+ +    K    +    + + K  L+ Q +E++ + + 
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550

Query: 62   LKQELEQLKEAFGQ----SFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELK 117
            L+ EL+  ++A  +      ++  +   D + R+E    ++  K      ++ E + EL+
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDE----QNEEKRRQLQRQLHEYETELE 1606

Query: 118  QSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDE-IREYKFREARLLQDYTELE 176
              R       A  ++L   ++DL    E+     I+ ++E I++ +  +A++     ELE
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDL----ELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662

Query: 177  EENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALE 236
            +   +  ++ +T K+N+ + + L+ ++ + +E+        + A   KE    +L  +L 
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722

Query: 237  TLKNEREQKNNLRKELSQY---ISLNDNHISISVDGLKFAEDGSEPNNDD--------KM 285
                 +++K  L   ++Q    +     ++    D ++ A   +E  +++        + 
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782

Query: 286  NGHIHGPLVKLNGDYRTPTLR-KGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILL 344
            N      L + N + R+     +G   +      + L  ++I +L++Q+ Q  REK    
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE-AKIAQLEEQVEQEAREKQAAT 1841

Query: 345  ANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAH 404
             +L++   +L+     + ++ +   +  E   A +G    K+LK +L         EEA 
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKE--QAEKGNARVKQLKRQL---------EEAE 1890

Query: 405  DYEVDIN-GLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVE 446
            +    IN     L+ +   A      +  E+ ALK K  +  E
Sbjct: 1891 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 45/171 (26%), Positives = 73/171 (42%), Gaps = 8/171 (4%)

Query: 645 RSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKR--EQIATLRAVLKANKQTA 702
           R  QL+  +   R  A  +            K+K LL   R  E++      L+  K+  
Sbjct: 809 RQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQ 868

Query: 703 EVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEM 762
           + A   LK + E + + +TE    L+ +L+A  E  A    +R   A +  E    L EM
Sbjct: 869 QKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927

Query: 763 QRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGK 813
           + +L   ED  + L    +   QQ L L ++LE+     E++ R K +L K
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-----EEAARQKLQLEK 973


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  103 bits (257), Expect = 7e-22
 Identities = 170/831 (20%), Positives = 335/831 (40%), Gaps = 146/831 (17%)

Query: 46   LTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYY 105
            L + +Q +E++A+ D L++  E+ ++A  +   + +K ++   T E+ LLQE    E   
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ--LTEEKNLLQEQLQAETEL 909

Query: 106  LGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFRE 165
              +  EM+  L   +  +  +  E E   A +++ ++  + ++ +R +M  ++ + +   
Sbjct: 910  YAEAEEMRVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKKMAQQMLDLE--- 963

Query: 166  ARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKE 225
                    +LEEE    QKL       Q+E    + +IK+ E+E ++++ Q     + ++
Sbjct: 964  -------EQLEEEEAARQKL-------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009

Query: 226  IAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKM 285
            + E ++ +    L  E E+  NL K       L + H S+       +E       ++K 
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTK-------LKNKHESM------ISELEVRLKKEEKS 1056

Query: 286  NGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLA 345
               +     KL GD         +    ++DL ++     I +LK QL + E E    LA
Sbjct: 1057 RQELEKLKRKLEGD-------ASDFHEQIADLQAQ-----IAELKMQLAKKEEELQAALA 1104

Query: 346  NLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHD 405
             L +   Q  +    + E    +  L E +++ R  ++  E       ++ RD GEE   
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE-------KQKRDLGEELEA 1157

Query: 406  YEVDINGL-------EILECKYRVAVT--------EVIDLKAEIKALKEKYNKSVENYTD 450
             + ++          + L  K    VT        E    +A+++ +++K+ ++VE  T+
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217

Query: 451  EKAKYESKIQMYDEQVTSLEKTTKE----------SGEKMAHMEKELQKMTSIANENHST 500
            +  +++      D+   +LEK   +          + +++ H +K+L+          S 
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277

Query: 501  LNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLS 560
               A+ EL     +L      V    NE   + +    + ++   S S +  D    L  
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAI----KLAKDVASLSSQLQDTQELLQE 1333

Query: 561  PRLARRGVSSPV----ETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTS 616
                +  VS+ +    E R S +    E  EA +             +    S+  +  S
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN------------LERHISTLNIQLS 1381

Query: 617  DIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILK 676
            D +K+  +  +    + +  K  QK ++   Q   ++AAA +    ++K K  L +E+  
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD---KLEKTKNRLQQELDD 1438

Query: 677  LKSLLSTKREQIATL-RAVLKANKQTAEVALANLKNKYENEK----AMVTETMTK----- 726
            L   L  +R+ ++ L +   K ++  AE    N+ +KY +E+    A   E  TK     
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEK--NISSKYADERDRAEAEAREKETKALSLA 1496

Query: 727  --LRNELKALKEDAATFSSLRA------------------------MFATRCDEYVTQLD 760
              L   L+A +E   T   L+A                           T+ +E  TQL+
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556

Query: 761  EMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKL 811
            E++ +L A ED K      LR+ +  +    Q   DL+   EQ+   + +L
Sbjct: 1557 ELEDELQATEDAK------LRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 173/827 (20%), Positives = 329/827 (39%), Gaps = 148/827 (17%)

Query: 16   EIERLTKELTETT--HE-KIQAAEYGLVVLEEKLTLK-QQYDELEAEYDSLKQELEQLKE 71
            E+  L K L E T  HE ++Q          E+LT + +Q+   +A  D  KQ LE+   
Sbjct: 1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241

Query: 72   AFGQSFSIHRKVAEDGETREETL---LQESASK-------EAYYLGKILEMQNELKQSRA 121
                   +  +  ++ E +++ L   +QE  SK        A    K+ ++QNE++    
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301

Query: 122  VVTNVQAENERL-------TAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTE 174
            ++   + +  +L       ++ +QD +E  +    Q++ +  ++R+ +  E   LQD  +
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE-EERNSLQDQLD 1360

Query: 175  LEEE------------NITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAI- 221
             E E            NI L      L+      E L+   KRF++E   L  Q E+   
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420

Query: 222  ------RLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAE- 274
                  + K   + +L++ +  L N+R+  +NL K+  ++  L     +IS    K+A+ 
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS---KYADE 1477

Query: 275  -DGSEPNNDDK------MNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQ 327
             D +E    +K      +   +   L       RT  + K E    + DL     +S   
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE----MEDL-----VSSKD 1528

Query: 328  KLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKEL 387
             + + + ++E+ K  L   ++E +TQLE  +  L    +   RL  ++ A++G Q  ++L
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG-QFERDL 1587

Query: 388  KA--ELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSV 445
            +A  E + EK R    + H+YE                 TE+ D + + +AL     K +
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYE-----------------TELEDERKQ-RALAAAAKKKL 1629

Query: 446  E-NYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTA 504
            E +  D + + +S I+  +E +  L K   +    M   ++EL+   +  +E  +T    
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQ----MKDFQRELEDARASRDEIFATAKEN 1685

Query: 505  QDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLA 564
            + +  +   +L QL                 D     R  +   L+  +    L S    
Sbjct: 1686 EKKAKSLEADLMQLQE---------------DLAAAERARKQADLEKEELAEELASSLSG 1730

Query: 565  RRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMN 624
            R  +    E R     +A+   E  +E                                 
Sbjct: 1731 RNALQD--EKRRLEARIAQLEEELEEEQG------------------------------- 1757

Query: 625  IYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTK 684
              N+ A+  D+++   KA  ++ QLS + A  R  A   +  ++ L  +  +L+S L   
Sbjct: 1758 --NMEAM-SDRVR---KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL--- 1808

Query: 685  REQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSL 744
             E    +++  K+     E  +A L+ + E E          L+ + K LKE        
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868

Query: 745  RAM---FATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKL 788
            R M   +  + ++   ++ +++RQL  AE+E + +N   R  +Q++L
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA-NRRKLQREL 1914



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 179/905 (19%), Positives = 368/905 (40%), Gaps = 167/905 (18%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTH---EKIQAAEYGLVVLEE-KLTLKQQYDELEAEY 59
            +E  Q  ++   E+E+   +LTE  +   E++QA        EE ++ L  +  ELE   
Sbjct: 872  KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 931

Query: 60   DSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKIL--------- 110
              ++  LE+ ++   Q  +  +K+A+     EE L +E A+++   L K+          
Sbjct: 932  HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 991

Query: 111  -------EMQNELKQSRAVV--------TNVQAENERLTAVVQDLKENNEMVELQRIRMK 155
                   +  N+L + R ++        TN+  E E+   + +   ++  M+    +R+K
Sbjct: 992  DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051

Query: 156  DEIR---EYKFREARLLQDYTELEEENITLQKLVSTLK-QNQVEYEGLKHEIKRFEEETV 211
             E +   E +  + +L  D ++  E+   LQ  ++ LK Q   + E L+  + R ++E  
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111

Query: 212  LLNSQLEDAIRLKEIAEH--QLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDG 269
              N+ L+   +++E+  H   L+E L++ +  R +    +++L + +      +  ++D 
Sbjct: 1112 QKNNALK---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1168

Query: 270  -----------------LKFAEDGSEPNNDDKMNG--HIHGPLV-------------KLN 297
                             LK A D    +++ ++      H   V             K N
Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN 1228

Query: 298  GDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHT 357
             D    TL K  +     DL  EL +     L Q   +VE +K  L A +QE Q++    
Sbjct: 1229 LDKNKQTLEKENA-----DLAGELRV-----LGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278

Query: 358  KGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILE 417
            + A  E +++VH+L   V ++ G+ +  E KA    +       +  D +      E+L+
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ------ELLQ 1332

Query: 418  CKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESG 477
             + R    + +++  +++ L+E+ N S+++  DE+ + +  ++ +   +++L     +S 
Sbjct: 1333 EETR----QKLNVSTKLRQLEEERN-SLQDQLDEEMEAKQNLERH---ISTLNIQLSDSK 1384

Query: 478  EKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDY 537
            +K+      ++ +     E         + L    EE A  Y  +     +T NR+  + 
Sbjct: 1385 KKLQDFASTVEAL----EEGKKRFQKEIENLTQQYEEKAAAYDKL----EKTKNRLQQEL 1436

Query: 538  YRQSRVTRSGSLKGPDDPRGLLS--PRLARRGVSSPVETRTSSEPVAKESTEASKEPSPT 595
                       +   D+ R L+S   +  R+      E +  S   A E   A  E    
Sbjct: 1437 --------DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

Query: 596  KTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAA 655
            +T  +S        +  L+ +   KE +     N +++ +++ L  + D           
Sbjct: 1489 ETKALS-------LARALEEALEAKEELE--RTNKMLKAEMEDLVSSKD----------D 1529

Query: 656  ARELAPMIDKDKEALMEEILKLKSLLSTKREQI-ATLRAVLKANKQTAEVALANLKNKYE 714
              +    ++K K AL  ++ ++K+ L    +++ AT  A L+      EV +  LK ++E
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-----LEVNMQALKGQFE 1584

Query: 715  NEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKK 774
             +     E   + R +L+                  +  EY T+L++ ++Q A A   KK
Sbjct: 1585 RDLQARDEQNEEKRRQLQ-----------------RQLHEYETELEDERKQRALAAAAKK 1627

Query: 775  TLNTLLR--------------MAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPK 820
             L   L+               AI+Q   L  +++D + + E +R S+ ++  +   + K
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687

Query: 821  IVSSL 825
               SL
Sbjct: 1688 KAKSL 1692



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 189/888 (21%), Positives = 342/888 (38%), Gaps = 143/888 (16%)

Query: 7    LQTVDHYKTEIERLTKEL---TETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLK 63
            L+  +  + E+E+L ++L       HE+I  A+    + E K+ L ++ +EL+A    L 
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQI--ADLQAQIAELKMQLAKKEEELQAALARLD 1107

Query: 64   QELEQLKEAFGQSFSIHRKVAEDGETRE-ETLLQESASKEAYYLGKILE-MQNELKQ--- 118
             E+ Q   A  +   +   +++  E  + E   +  A K+   LG+ LE ++ EL+    
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167

Query: 119  SRAVVTNVQAENERLTAVVQ---DLKENNEMVELQRIRMK---------DEIREYKFREA 166
            S A    ++A+ E+   V++   D +  +   ++Q +R K         +++ ++K  +A
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227

Query: 167  RLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLK-E 225
             L ++   LE+EN  L   +  L Q + E E   H+ K+ E +   L S+  D  R + E
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVE---HKKKKLEAQVQELQSKCSDGERARAE 1284

Query: 226  IAE--HQLEEALETLK---NEREQKN-NLRKELSQYIS-LNDN------------HISIS 266
            + +  H+L+  +E++    NE E K   L K+++   S L D             ++S  
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344

Query: 267  VDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISE- 325
            +  L+   +  +   D++M    +     L     T  ++  +S   + D  S +   E 
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQN-----LERHISTLNIQLSDSKKKLQDFASTVEALEE 1399

Query: 326  ----IQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRG- 380
                 QK  + L Q   EKA     L++++ +L+     L    +   +L  ++   +  
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1459

Query: 381  ----LQSSKELKAELDGEKGRDSGEEAHDYEVDINGL-----EILECKYRVAVTEVIDLK 431
                L   K + ++   E+ R   E A + E     L     E LE K  +  T  + LK
Sbjct: 1460 FDQLLAEEKNISSKYADERDRAEAE-AREKETKALSLARALEEALEAKEELERTNKM-LK 1517

Query: 432  AEIKAL---KEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQ 488
            AE++ L   K+   K+V      K   E++++    Q+  LE   + + +    +E  +Q
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577

Query: 489  KMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGS 548
               ++  +    L    ++      +L +  H       ET    + D  +Q  +  +  
Sbjct: 1578 ---ALKGQFERDLQARDEQNEEKRRQLQRQLHEY-----ETE---LEDERKQRALAAAAK 1626

Query: 549  LKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPP 608
             K   D + L                   ++   K   EA K+            + A  
Sbjct: 1627 KKLEGDLKDL----------------ELQADSAIKGREEAIKQLRK---------LQAQM 1661

Query: 609  SSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKE 668
                 +  D R     I+   A  ++  K  +      +QL    AAA       D +KE
Sbjct: 1662 KDFQRELEDARASRDEIF---ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718

Query: 669  ALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKA---------- 718
             L EE   L S LS         R  L+  K+  E  +A L+ + E E+           
Sbjct: 1719 ELAEE---LASSLSG--------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767

Query: 719  MVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNT 778
              T+   +L NEL   +  A    S R     +  E  ++L EM+   A     K T+  
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG--AVKSKFKSTI-- 1823

Query: 779  LLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKIVSSLL 826
                      AL  ++  LE   EQ  R K    KS     K +  +L
Sbjct: 1824 ---------AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 112/544 (20%), Positives = 214/544 (39%), Gaps = 85/544 (15%)

Query: 13   YKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ---ELEQL 69
            ++ EIE LT++  E      +AA Y  +  + K  L+Q+ D+L  + D+ +Q    LE+ 
Sbjct: 1404 FQKEIENLTQQYEE------KAAAYDKLE-KTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456

Query: 70   KEAFGQSFSIHRKVAE---DGETREETLLQESASKE---AYYLGKILEMQNELKQSRAVV 123
            +  F Q  +  + ++    D   R E   +E  +K    A  L + LE + EL+++  + 
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM- 1515

Query: 124  TNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQ 183
              ++AE E L +   D+ +N   +E  +  ++ ++ E K +   L  +    E+  + L+
Sbjct: 1516 --LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 184  KLVSTLK------------QNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQL 231
              +  LK            QN+ +   L+ ++  +E E      Q   A   K+  E  L
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633

Query: 232  --------------EEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGS 277
                          EEA++ L+  + Q  + ++EL    +  D   + + +  K A+   
Sbjct: 1634 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS-- 1691

Query: 278  EPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVE 337
                       +   L++L  D     L   E     +DL  E    E+         ++
Sbjct: 1692 -----------LEADLMQLQED-----LAAAERARKQADLEKEELAEELASSLSGRNALQ 1735

Query: 338  REKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGR 397
             EK  L A + + + +LE  +G +    +RV + T         Q +++L  EL  E+  
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT---------QQAEQLSNELATERST 1786

Query: 398  DSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDE------ 451
                E+   +++    E+    + +        K+ I AL+ K  +  E    E      
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1846

Query: 452  -------KAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTA 504
                   K K   +I +  E    + +  KE  EK     K+L++    A E    +N  
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906

Query: 505  QDEL 508
            + +L
Sbjct: 1907 RRKL 1910



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 86/463 (18%), Positives = 195/463 (42%), Gaps = 38/463 (8%)

Query: 2    AAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDS 61
            A EE L+  +  +   + L  E+ +    K    +    + + K  L+ Q +E++ + + 
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557

Query: 62   LKQELEQLKEAFGQ----SFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELK 117
            L+ EL+  ++A  +      ++  +   D + R+E    ++  K      ++ E + EL+
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDE----QNEEKRRQLQRQLHEYETELE 1613

Query: 118  QSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDE-IREYKFREARLLQDYTELE 176
              R       A  ++L   ++DL    E+     I+ ++E I++ +  +A++     ELE
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDL----ELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669

Query: 177  EENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALE 236
            +   +  ++ +T K+N+ + + L+ ++ + +E+        + A   KE    +L  +L 
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729

Query: 237  TLKNEREQKNNLRKELSQY---ISLNDNHISISVDGLKFAEDGSEPNNDD--------KM 285
                 +++K  L   ++Q    +     ++    D ++ A   +E  +++        + 
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789

Query: 286  NGHIHGPLVKLNGDYRTPTLR-KGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILL 344
            N      L + N + R+     +G   +      + L  ++I +L++Q+ Q  REK    
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE-AKIAQLEEQVEQEAREKQAAT 1848

Query: 345  ANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAH 404
             +L++   +L+     + ++ +   +  E   A +G    K+LK +L         EEA 
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKE--QAEKGNARVKQLKRQL---------EEAE 1897

Query: 405  DYEVDIN-GLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVE 446
            +    IN     L+ +   A      +  E+ ALK K  +  E
Sbjct: 1898 EESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 45/171 (26%), Positives = 73/171 (42%), Gaps = 8/171 (4%)

Query: 645 RSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKR--EQIATLRAVLKANKQTA 702
           R  QL+  +   R  A  +            K+K LL   R  E++      L+  K+  
Sbjct: 816 RQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQ 875

Query: 703 EVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEM 762
           + A   LK + E + + +TE    L+ +L+A  E  A    +R   A +  E    L EM
Sbjct: 876 QKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934

Query: 763 QRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGK 813
           + +L   ED  + L    +   QQ L L ++LE+     E++ R K +L K
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-----EEAARQKLQLEK 980


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  103 bits (257), Expect = 7e-22
 Identities = 170/831 (20%), Positives = 335/831 (40%), Gaps = 146/831 (17%)

Query: 46   LTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYY 105
            L + +Q +E++A+ D L++  E+ ++A  +   + +K ++   T E+ LLQE    E   
Sbjct: 852  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ--LTEEKNLLQEQLQAETEL 909

Query: 106  LGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFRE 165
              +  EM+  L   +  +  +  E E   A +++ ++  + ++ +R +M  ++ + +   
Sbjct: 910  YAEAEEMRVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKKMAQQMLDLE--- 963

Query: 166  ARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKE 225
                    +LEEE    QKL       Q+E    + +IK+ E+E ++++ Q     + ++
Sbjct: 964  -------EQLEEEEAARQKL-------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009

Query: 226  IAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKM 285
            + E ++ +    L  E E+  NL K       L + H S+       +E       ++K 
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTK-------LKNKHESM------ISELEVRLKKEEKS 1056

Query: 286  NGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLA 345
               +     KL GD         +    ++DL ++     I +LK QL + E E    LA
Sbjct: 1057 RQELEKLKRKLEGD-------ASDFHEQIADLQAQ-----IAELKMQLAKKEEELQAALA 1104

Query: 346  NLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHD 405
             L +   Q  +    + E    +  L E +++ R  ++  E       ++ RD GEE   
Sbjct: 1105 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE-------KQKRDLGEELEA 1157

Query: 406  YEVDINGL-------EILECKYRVAVT--------EVIDLKAEIKALKEKYNKSVENYTD 450
             + ++          + L  K    VT        E    +A+++ +++K+ ++VE  T+
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217

Query: 451  EKAKYESKIQMYDEQVTSLEKTTKE----------SGEKMAHMEKELQKMTSIANENHST 500
            +  +++      D+   +LEK   +          + +++ H +K+L+          S 
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277

Query: 501  LNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLS 560
               A+ EL     +L      V    NE   + +    + ++   S S +  D    L  
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAI----KLAKDVASLSSQLQDTQELLQE 1333

Query: 561  PRLARRGVSSPV----ETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTS 616
                +  VS+ +    E R S +    E  EA +             +    S+  +  S
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN------------LERHISTLNIQLS 1381

Query: 617  DIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILK 676
            D +K+  +  +    + +  K  QK ++   Q   ++AAA +    ++K K  L +E+  
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD---KLEKTKNRLQQELDD 1438

Query: 677  LKSLLSTKREQIATL-RAVLKANKQTAEVALANLKNKYENEK----AMVTETMTK----- 726
            L   L  +R+ ++ L +   K ++  AE    N+ +KY +E+    A   E  TK     
Sbjct: 1439 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEK--NISSKYADERDRAEAEAREKETKALSLA 1496

Query: 727  --LRNELKALKEDAATFSSLRA------------------------MFATRCDEYVTQLD 760
              L   L+A +E   T   L+A                           T+ +E  TQL+
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556

Query: 761  EMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKL 811
            E++ +L A ED K      LR+ +  +    Q   DL+   EQ+   + +L
Sbjct: 1557 ELEDELQATEDAK------LRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1601



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 179/858 (20%), Positives = 338/858 (39%), Gaps = 155/858 (18%)

Query: 16   EIERLTKELTETT--HE-KIQAAEYGLVVLEEKLTLK-QQYDELEAEYDSLKQELEQLKE 71
            E+  L K L E T  HE ++Q          E+LT + +Q+   +A  D  KQ LE+   
Sbjct: 1182 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241

Query: 72   AFGQSFSIHRKVAEDGETREETL---LQESASK-------EAYYLGKILEMQNELKQSRA 121
                   +  +  ++ E +++ L   +QE  SK        A    K+ ++QNE++    
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1301

Query: 122  VVTNVQAENERL-------TAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTE 174
            ++   + +  +L       ++ +QD +E  +    Q++ +  ++R+ +  E   LQD  +
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE-EERNSLQDQLD 1360

Query: 175  LEEE------------NITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAI- 221
             E E            NI L      L+      E L+   KRF++E   L  Q E+   
Sbjct: 1361 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1420

Query: 222  ------RLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAE- 274
                  + K   + +L++ +  L N+R+  +NL K+  ++  L     +IS    K+A+ 
Sbjct: 1421 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS---KYADE 1477

Query: 275  -DGSEPNNDDK------MNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQ 327
             D +E    +K      +   +   L       RT  + K E    + DL     +S   
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE----MEDL-----VSSKD 1528

Query: 328  KLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKEL 387
             + + + ++E+ K  L   ++E +TQLE  +  L    +   RL  ++ A++G Q  ++L
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG-QFERDL 1587

Query: 388  KA--ELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSV 445
            +A  E + EK R    + H+YE                 TE+ D + + +AL     K +
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYE-----------------TELEDERKQ-RALAAAAKKKL 1629

Query: 446  E-NYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTA 504
            E +  D + + +S I+  +E +  L K   +    M   ++EL+   +  +E  +T    
Sbjct: 1630 EGDLKDLELQADSAIKGREEAIKQLRKLQAQ----MKDFQRELEDARASRDEIFATAKEN 1685

Query: 505  QDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLA 564
            + +  +   +L QL                 D     R  +   L+  +    L S    
Sbjct: 1686 EKKAKSLEADLMQLQE---------------DLAAAERARKQADLEKEELAEELASSLSG 1730

Query: 565  RRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMN 624
            R  +    E R     +A+   E  +E                                 
Sbjct: 1731 RNALQD--EKRRLEARIAQLEEELEEEQG------------------------------- 1757

Query: 625  IYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTK 684
              N+ A+  D+++   KA  ++ QLS + A  R  A   +  ++ L  +  +L+S L   
Sbjct: 1758 --NMEAM-SDRVR---KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL--- 1808

Query: 685  REQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSL 744
             E    +++  K+     E  +A L+ + E E          L+ + K LKE        
Sbjct: 1809 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1868

Query: 745  RAM---FATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDH 801
            R M   +  + ++   ++ +++RQL  AE+E + +N         +  L + L++    +
Sbjct: 1869 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA-------NRRKLQRELDEATESN 1921

Query: 802  EQSRRSKGKLGKSKIGSP 819
            E   R    L KSK+  P
Sbjct: 1922 EAMGREVNAL-KSKLRGP 1938



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 179/905 (19%), Positives = 368/905 (40%), Gaps = 167/905 (18%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTH---EKIQAAEYGLVVLEE-KLTLKQQYDELEAEY 59
            +E  Q  ++   E+E+   +LTE  +   E++QA        EE ++ L  +  ELE   
Sbjct: 872  KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 931

Query: 60   DSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKIL--------- 110
              ++  LE+ ++   Q  +  +K+A+     EE L +E A+++   L K+          
Sbjct: 932  HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 991

Query: 111  -------EMQNELKQSRAVV--------TNVQAENERLTAVVQDLKENNEMVELQRIRMK 155
                   +  N+L + R ++        TN+  E E+   + +   ++  M+    +R+K
Sbjct: 992  DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051

Query: 156  DEIR---EYKFREARLLQDYTELEEENITLQKLVSTLK-QNQVEYEGLKHEIKRFEEETV 211
             E +   E +  + +L  D ++  E+   LQ  ++ LK Q   + E L+  + R ++E  
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111

Query: 212  LLNSQLEDAIRLKEIAEH--QLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDG 269
              N+ L+   +++E+  H   L+E L++ +  R +    +++L + +      +  ++D 
Sbjct: 1112 QKNNALK---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1168

Query: 270  -----------------LKFAEDGSEPNNDDKMNG--HIHGPLV-------------KLN 297
                             LK A D    +++ ++      H   V             K N
Sbjct: 1169 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN 1228

Query: 298  GDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHT 357
             D    TL K  +     DL  EL +     L Q   +VE +K  L A +QE Q++    
Sbjct: 1229 LDKNKQTLEKENA-----DLAGELRV-----LGQAKQEVEHKKKKLEAQVQELQSKCSDG 1278

Query: 358  KGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILE 417
            + A  E +++VH+L   V ++ G+ +  E KA    +       +  D +      E+L+
Sbjct: 1279 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ------ELLQ 1332

Query: 418  CKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESG 477
             + R    + +++  +++ L+E+ N S+++  DE+ + +  ++ +   +++L     +S 
Sbjct: 1333 EETR----QKLNVSTKLRQLEEERN-SLQDQLDEEMEAKQNLERH---ISTLNIQLSDSK 1384

Query: 478  EKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDY 537
            +K+      ++ +     E         + L    EE A  Y  +     +T NR+  + 
Sbjct: 1385 KKLQDFASTVEAL----EEGKKRFQKEIENLTQQYEEKAAAYDKL----EKTKNRLQQEL 1436

Query: 538  YRQSRVTRSGSLKGPDDPRGLLS--PRLARRGVSSPVETRTSSEPVAKESTEASKEPSPT 595
                       +   D+ R L+S   +  R+      E +  S   A E   A  E    
Sbjct: 1437 --------DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488

Query: 596  KTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAA 655
            +T  +S        +  L+ +   KE +     N +++ +++ L  + D           
Sbjct: 1489 ETKALS-------LARALEEALEAKEELE--RTNKMLKAEMEDLVSSKD----------D 1529

Query: 656  ARELAPMIDKDKEALMEEILKLKSLLSTKREQI-ATLRAVLKANKQTAEVALANLKNKYE 714
              +    ++K K AL  ++ ++K+ L    +++ AT  A L+      EV +  LK ++E
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-----LEVNMQALKGQFE 1584

Query: 715  NEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKK 774
             +     E   + R +L+                  +  EY T+L++ ++Q A A   KK
Sbjct: 1585 RDLQARDEQNEEKRRQLQ-----------------RQLHEYETELEDERKQRALAAAAKK 1627

Query: 775  TLNTLLR--------------MAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPK 820
             L   L+               AI+Q   L  +++D + + E +R S+ ++  +   + K
Sbjct: 1628 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1687

Query: 821  IVSSL 825
               SL
Sbjct: 1688 KAKSL 1692



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 189/888 (21%), Positives = 342/888 (38%), Gaps = 143/888 (16%)

Query: 7    LQTVDHYKTEIERLTKEL---TETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLK 63
            L+  +  + E+E+L ++L       HE+I  A+    + E K+ L ++ +EL+A    L 
Sbjct: 1050 LKKEEKSRQELEKLKRKLEGDASDFHEQI--ADLQAQIAELKMQLAKKEEELQAALARLD 1107

Query: 64   QELEQLKEAFGQSFSIHRKVAEDGETRE-ETLLQESASKEAYYLGKILE-MQNELKQ--- 118
             E+ Q   A  +   +   +++  E  + E   +  A K+   LG+ LE ++ EL+    
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167

Query: 119  SRAVVTNVQAENERLTAVVQ---DLKENNEMVELQRIRMK---------DEIREYKFREA 166
            S A    ++A+ E+   V++   D +  +   ++Q +R K         +++ ++K  +A
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227

Query: 167  RLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLK-E 225
             L ++   LE+EN  L   +  L Q + E E   H+ K+ E +   L S+  D  R + E
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVE---HKKKKLEAQVQELQSKCSDGERARAE 1284

Query: 226  IAE--HQLEEALETLK---NEREQKN-NLRKELSQYIS-LNDN------------HISIS 266
            + +  H+L+  +E++    NE E K   L K+++   S L D             ++S  
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344

Query: 267  VDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISE- 325
            +  L+   +  +   D++M    +     L     T  ++  +S   + D  S +   E 
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQN-----LERHISTLNIQLSDSKKKLQDFASTVEALEE 1399

Query: 326  ----IQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRG- 380
                 QK  + L Q   EKA     L++++ +L+     L    +   +L  ++   +  
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1459

Query: 381  ----LQSSKELKAELDGEKGRDSGEEAHDYEVDINGL-----EILECKYRVAVTEVIDLK 431
                L   K + ++   E+ R   E A + E     L     E LE K  +  T  + LK
Sbjct: 1460 FDQLLAEEKNISSKYADERDRAEAE-AREKETKALSLARALEEALEAKEELERTNKM-LK 1517

Query: 432  AEIKAL---KEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQ 488
            AE++ L   K+   K+V      K   E++++    Q+  LE   + + +    +E  +Q
Sbjct: 1518 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577

Query: 489  KMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGS 548
               ++  +    L    ++      +L +  H       ET    + D  +Q  +  +  
Sbjct: 1578 ---ALKGQFERDLQARDEQNEEKRRQLQRQLHEY-----ETE---LEDERKQRALAAAAK 1626

Query: 549  LKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPP 608
             K   D + L                   ++   K   EA K+            + A  
Sbjct: 1627 KKLEGDLKDL----------------ELQADSAIKGREEAIKQLRK---------LQAQM 1661

Query: 609  SSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKE 668
                 +  D R     I+   A  ++  K  +      +QL    AAA       D +KE
Sbjct: 1662 KDFQRELEDARASRDEIF---ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718

Query: 669  ALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKA---------- 718
             L EE   L S LS         R  L+  K+  E  +A L+ + E E+           
Sbjct: 1719 ELAEE---LASSLSG--------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767

Query: 719  MVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNT 778
              T+   +L NEL   +  A    S R     +  E  ++L EM+   A     K T+  
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG--AVKSKFKSTI-- 1823

Query: 779  LLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKIVSSLL 826
                      AL  ++  LE   EQ  R K    KS     K +  +L
Sbjct: 1824 ---------AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1862



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 112/544 (20%), Positives = 214/544 (39%), Gaps = 85/544 (15%)

Query: 13   YKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ---ELEQL 69
            ++ EIE LT++  E      +AA Y  +  + K  L+Q+ D+L  + D+ +Q    LE+ 
Sbjct: 1404 FQKEIENLTQQYEE------KAAAYDKLE-KTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456

Query: 70   KEAFGQSFSIHRKVAE---DGETREETLLQESASKE---AYYLGKILEMQNELKQSRAVV 123
            +  F Q  +  + ++    D   R E   +E  +K    A  L + LE + EL+++  + 
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM- 1515

Query: 124  TNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQ 183
              ++AE E L +   D+ +N   +E  +  ++ ++ E K +   L  +    E+  + L+
Sbjct: 1516 --LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 184  KLVSTLK------------QNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQL 231
              +  LK            QN+ +   L+ ++  +E E      Q   A   K+  E  L
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633

Query: 232  --------------EEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGS 277
                          EEA++ L+  + Q  + ++EL    +  D   + + +  K A+   
Sbjct: 1634 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS-- 1691

Query: 278  EPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVE 337
                       +   L++L  D     L   E     +DL  E    E+         ++
Sbjct: 1692 -----------LEADLMQLQED-----LAAAERARKQADLEKEELAEELASSLSGRNALQ 1735

Query: 338  REKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGR 397
             EK  L A + + + +LE  +G +    +RV + T         Q +++L  EL  E+  
Sbjct: 1736 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT---------QQAEQLSNELATERST 1786

Query: 398  DSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDE------ 451
                E+   +++    E+    + +        K+ I AL+ K  +  E    E      
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1846

Query: 452  -------KAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTA 504
                   K K   +I +  E    + +  KE  EK     K+L++    A E    +N  
Sbjct: 1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906

Query: 505  QDEL 508
            + +L
Sbjct: 1907 RRKL 1910



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 73/408 (17%), Positives = 177/408 (43%), Gaps = 28/408 (6%)

Query: 2    AAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDS 61
            A EE L+  +  +   + L  E+ +    K    +    + + K  L+ Q +E++ + + 
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557

Query: 62   LKQELEQLKEAFGQ----SFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELK 117
            L+ EL+  ++A  +      ++  +   D + R+E    ++  K      ++ E + EL+
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDE----QNEEKRRQLQRQLHEYETELE 1613

Query: 118  QSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDE-IREYKFREARLLQDYTELE 176
              R       A  ++L   ++DL    E+     I+ ++E I++ +  +A++     ELE
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDL----ELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669

Query: 177  EENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALE 236
            +   +  ++ +T K+N+ + + L+ ++ + +E+        + A   KE    +L  +L 
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729

Query: 237  TLKNEREQKNNLRKELSQY---ISLNDNHISISVDGLKFAEDGSEPNNDD--------KM 285
                 +++K  L   ++Q    +     ++    D ++ A   +E  +++        + 
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789

Query: 286  NGHIHGPLVKLNGDYRTPTLR-KGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILL 344
            N      L + N + R+     +G   +      + L  ++I +L++Q+ Q  REK    
Sbjct: 1790 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE-AKIAQLEEQVEQEAREKQAAT 1848

Query: 345  ANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELD 392
             +L++   +L+     + ++ +   +  E   A +G    K+LK +L+
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKE--QAEKGNARVKQLKRQLE 1894



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 45/171 (26%), Positives = 73/171 (42%), Gaps = 8/171 (4%)

Query: 645 RSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKR--EQIATLRAVLKANKQTA 702
           R  QL+  +   R  A  +            K+K LL   R  E++      L+  K+  
Sbjct: 816 RQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQ 875

Query: 703 EVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEM 762
           + A   LK + E + + +TE    L+ +L+A  E  A    +R   A +  E    L EM
Sbjct: 876 QKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934

Query: 763 QRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGK 813
           + +L   ED  + L    +   QQ L L ++LE+     E++ R K +L K
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-----EEAARQKLQLEK 980



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 64/255 (25%), Positives = 109/255 (42%), Gaps = 33/255 (12%)

Query: 48   LKQQYDELEAEYDSLKQ---ELEQLKEAFGQSFSIHRKVAEDGETR--------EETLLQ 96
            L Q  ++L A   + KQ   E E+L E    S S  R   +D + R        EE L +
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLS-GRNALQDEKRRLEARIAQLEEELEE 1754

Query: 97   ESASKEAYY--LGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRM 154
            E  + EA    + K  +   +L    A   +   +NE   +  Q L+  N+ +  +   M
Sbjct: 1755 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE---SARQQLERQNKELRSKLHEM 1811

Query: 155  KDEIREYKFR------EARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEE 208
            +  ++  KF+      EA++ Q   ++E+E    Q    +LKQ   +   LK  + + E+
Sbjct: 1812 EGAVKS-KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK---LKEILLQVED 1867

Query: 209  ETVLLNSQLEDA----IRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHIS 264
            E  +     E A     R+K++ + QLEEA E  +     +  L++EL +    N+  + 
Sbjct: 1868 ERKMAEQYKEQAEKGNARVKQL-KRQLEEAEEESQRINANRRKLQRELDEATESNE-AMG 1925

Query: 265  ISVDGLKFAEDGSEP 279
              V+ LK    G  P
Sbjct: 1926 REVNALKSKLRGPPP 1940


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  103 bits (257), Expect = 7e-22
 Identities = 170/831 (20%), Positives = 335/831 (40%), Gaps = 146/831 (17%)

Query: 46   LTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYY 105
            L + +Q +E++A+ D L++  E+ ++A  +   + +K ++   T E+ LLQE    E   
Sbjct: 845  LQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ--LTEEKNLLQEQLQAETEL 902

Query: 106  LGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFRE 165
              +  EM+  L   +  +  +  E E   A +++ ++  + ++ +R +M  ++ + +   
Sbjct: 903  YAEAEEMRVRLAAKKQELEEILHEME---ARLEEEEDRGQQLQAERKKMAQQMLDLE--- 956

Query: 166  ARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKE 225
                    +LEEE    QKL       Q+E    + +IK+ E+E ++++ Q     + ++
Sbjct: 957  -------EQLEEEEAARQKL-------QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002

Query: 226  IAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKM 285
            + E ++ +    L  E E+  NL K       L + H S+       +E       ++K 
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTK-------LKNKHESM------ISELEVRLKKEEKS 1049

Query: 286  NGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLA 345
               +     KL GD         +    ++DL ++     I +LK QL + E E    LA
Sbjct: 1050 RQELEKLKRKLEGD-------ASDFHEQIADLQAQ-----IAELKMQLAKKEEELQAALA 1097

Query: 346  NLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHD 405
             L +   Q  +    + E    +  L E +++ R  ++  E       ++ RD GEE   
Sbjct: 1098 RLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE-------KQKRDLGEELEA 1150

Query: 406  YEVDINGL-------EILECKYRVAVT--------EVIDLKAEIKALKEKYNKSVENYTD 450
             + ++          + L  K    VT        E    +A+++ +++K+ ++VE  T+
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210

Query: 451  EKAKYESKIQMYDEQVTSLEKTTKE----------SGEKMAHMEKELQKMTSIANENHST 500
            +  +++      D+   +LEK   +          + +++ H +K+L+          S 
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270

Query: 501  LNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLS 560
               A+ EL     +L      V    NE   + +    + ++   S S +  D    L  
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAI----KLAKDVASLSSQLQDTQELLQE 1326

Query: 561  PRLARRGVSSPV----ETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTS 616
                +  VS+ +    E R S +    E  EA +             +    S+  +  S
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN------------LERHISTLNIQLS 1374

Query: 617  DIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILK 676
            D +K+  +  +    + +  K  QK ++   Q   ++AAA +    ++K K  L +E+  
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD---KLEKTKNRLQQELDD 1431

Query: 677  LKSLLSTKREQIATL-RAVLKANKQTAEVALANLKNKYENEK----AMVTETMTK----- 726
            L   L  +R+ ++ L +   K ++  AE    N+ +KY +E+    A   E  TK     
Sbjct: 1432 LVVDLDNQRQLVSNLEKKQRKFDQLLAEEK--NISSKYADERDRAEAEAREKETKALSLA 1489

Query: 727  --LRNELKALKEDAATFSSLRA------------------------MFATRCDEYVTQLD 760
              L   L+A +E   T   L+A                           T+ +E  TQL+
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549

Query: 761  EMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKL 811
            E++ +L A ED K      LR+ +  +    Q   DL+   EQ+   + +L
Sbjct: 1550 ELEDELQATEDAK------LRLEVNMQALKGQFERDLQARDEQNEEKRRQL 1594



 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 179/858 (20%), Positives = 338/858 (39%), Gaps = 155/858 (18%)

Query: 16   EIERLTKELTETT--HE-KIQAAEYGLVVLEEKLTLK-QQYDELEAEYDSLKQELEQLKE 71
            E+  L K L E T  HE ++Q          E+LT + +Q+   +A  D  KQ LE+   
Sbjct: 1175 EVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234

Query: 72   AFGQSFSIHRKVAEDGETREETL---LQESASK-------EAYYLGKILEMQNELKQSRA 121
                   +  +  ++ E +++ L   +QE  SK        A    K+ ++QNE++    
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTG 1294

Query: 122  VVTNVQAENERL-------TAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTE 174
            ++   + +  +L       ++ +QD +E  +    Q++ +  ++R+ +  E   LQD  +
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLE-EERNSLQDQLD 1353

Query: 175  LEEE------------NITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAI- 221
             E E            NI L      L+      E L+   KRF++E   L  Q E+   
Sbjct: 1354 EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAA 1413

Query: 222  ------RLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAE- 274
                  + K   + +L++ +  L N+R+  +NL K+  ++  L     +IS    K+A+ 
Sbjct: 1414 AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS---KYADE 1470

Query: 275  -DGSEPNNDDK------MNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQ 327
             D +E    +K      +   +   L       RT  + K E    + DL     +S   
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE----MEDL-----VSSKD 1521

Query: 328  KLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKEL 387
             + + + ++E+ K  L   ++E +TQLE  +  L    +   RL  ++ A++G Q  ++L
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG-QFERDL 1580

Query: 388  KA--ELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSV 445
            +A  E + EK R    + H+YE                 TE+ D + + +AL     K +
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYE-----------------TELEDERKQ-RALAAAAKKKL 1622

Query: 446  E-NYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTA 504
            E +  D + + +S I+  +E +  L K   +    M   ++EL+   +  +E  +T    
Sbjct: 1623 EGDLKDLELQADSAIKGREEAIKQLRKLQAQ----MKDFQRELEDARASRDEIFATAKEN 1678

Query: 505  QDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLA 564
            + +  +   +L QL                 D     R  +   L+  +    L S    
Sbjct: 1679 EKKAKSLEADLMQLQE---------------DLAAAERARKQADLEKEELAEELASSLSG 1723

Query: 565  RRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMN 624
            R  +    E R     +A+   E  +E                                 
Sbjct: 1724 RNALQD--EKRRLEARIAQLEEELEEEQG------------------------------- 1750

Query: 625  IYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTK 684
              N+ A+  D+++   KA  ++ QLS + A  R  A   +  ++ L  +  +L+S L   
Sbjct: 1751 --NMEAM-SDRVR---KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKL--- 1801

Query: 685  REQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSL 744
             E    +++  K+     E  +A L+ + E E          L+ + K LKE        
Sbjct: 1802 HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDE 1861

Query: 745  RAM---FATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDH 801
            R M   +  + ++   ++ +++RQL  AE+E + +N         +  L + L++    +
Sbjct: 1862 RKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA-------NRRKLQRELDEATESN 1914

Query: 802  EQSRRSKGKLGKSKIGSP 819
            E   R    L KSK+  P
Sbjct: 1915 EAMGREVNAL-KSKLRGP 1931



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 179/905 (19%), Positives = 368/905 (40%), Gaps = 167/905 (18%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTH---EKIQAAEYGLVVLEE-KLTLKQQYDELEAEY 59
            +E  Q  ++   E+E+   +LTE  +   E++QA        EE ++ L  +  ELE   
Sbjct: 865  KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 924

Query: 60   DSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKIL--------- 110
              ++  LE+ ++   Q  +  +K+A+     EE L +E A+++   L K+          
Sbjct: 925  HEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLE 984

Query: 111  -------EMQNELKQSRAVV--------TNVQAENERLTAVVQDLKENNEMVELQRIRMK 155
                   +  N+L + R ++        TN+  E E+   + +   ++  M+    +R+K
Sbjct: 985  DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044

Query: 156  DEIR---EYKFREARLLQDYTELEEENITLQKLVSTLK-QNQVEYEGLKHEIKRFEEETV 211
             E +   E +  + +L  D ++  E+   LQ  ++ LK Q   + E L+  + R ++E  
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1104

Query: 212  LLNSQLEDAIRLKEIAEH--QLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDG 269
              N+ L+   +++E+  H   L+E L++ +  R +    +++L + +      +  ++D 
Sbjct: 1105 QKNNALK---KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS 1161

Query: 270  -----------------LKFAEDGSEPNNDDKMNG--HIHGPLV-------------KLN 297
                             LK A D    +++ ++      H   V             K N
Sbjct: 1162 TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN 1221

Query: 298  GDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHT 357
             D    TL K  +     DL  EL +     L Q   +VE +K  L A +QE Q++    
Sbjct: 1222 LDKNKQTLEKENA-----DLAGELRV-----LGQAKQEVEHKKKKLEAQVQELQSKCSDG 1271

Query: 358  KGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILE 417
            + A  E +++VH+L   V ++ G+ +  E KA    +       +  D +      E+L+
Sbjct: 1272 ERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ------ELLQ 1325

Query: 418  CKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESG 477
             + R    + +++  +++ L+E+ N S+++  DE+ + +  ++ +   +++L     +S 
Sbjct: 1326 EETR----QKLNVSTKLRQLEEERN-SLQDQLDEEMEAKQNLERH---ISTLNIQLSDSK 1377

Query: 478  EKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDY 537
            +K+      ++ +     E         + L    EE A  Y  +     +T NR+  + 
Sbjct: 1378 KKLQDFASTVEAL----EEGKKRFQKEIENLTQQYEEKAAAYDKL----EKTKNRLQQEL 1429

Query: 538  YRQSRVTRSGSLKGPDDPRGLLS--PRLARRGVSSPVETRTSSEPVAKESTEASKEPSPT 595
                       +   D+ R L+S   +  R+      E +  S   A E   A  E    
Sbjct: 1430 --------DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481

Query: 596  KTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAA 655
            +T  +S        +  L+ +   KE +     N +++ +++ L  + D           
Sbjct: 1482 ETKALS-------LARALEEALEAKEELE--RTNKMLKAEMEDLVSSKD----------D 1522

Query: 656  ARELAPMIDKDKEALMEEILKLKSLLSTKREQI-ATLRAVLKANKQTAEVALANLKNKYE 714
              +    ++K K AL  ++ ++K+ L    +++ AT  A L+      EV +  LK ++E
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR-----LEVNMQALKGQFE 1577

Query: 715  NEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKK 774
             +     E   + R +L+                  +  EY T+L++ ++Q A A   KK
Sbjct: 1578 RDLQARDEQNEEKRRQLQ-----------------RQLHEYETELEDERKQRALAAAAKK 1620

Query: 775  TLNTLLR--------------MAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPK 820
             L   L+               AI+Q   L  +++D + + E +R S+ ++  +   + K
Sbjct: 1621 KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK 1680

Query: 821  IVSSL 825
               SL
Sbjct: 1681 KAKSL 1685



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 189/888 (21%), Positives = 342/888 (38%), Gaps = 143/888 (16%)

Query: 7    LQTVDHYKTEIERLTKEL---TETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLK 63
            L+  +  + E+E+L ++L       HE+I  A+    + E K+ L ++ +EL+A    L 
Sbjct: 1043 LKKEEKSRQELEKLKRKLEGDASDFHEQI--ADLQAQIAELKMQLAKKEEELQAALARLD 1100

Query: 64   QELEQLKEAFGQSFSIHRKVAEDGETRE-ETLLQESASKEAYYLGKILE-MQNELKQ--- 118
             E+ Q   A  +   +   +++  E  + E   +  A K+   LG+ LE ++ EL+    
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160

Query: 119  SRAVVTNVQAENERLTAVVQ---DLKENNEMVELQRIRMK---------DEIREYKFREA 166
            S A    ++A+ E+   V++   D +  +   ++Q +R K         +++ ++K  +A
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220

Query: 167  RLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLK-E 225
             L ++   LE+EN  L   +  L Q + E E   H+ K+ E +   L S+  D  R + E
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVE---HKKKKLEAQVQELQSKCSDGERARAE 1277

Query: 226  IAE--HQLEEALETLK---NEREQKN-NLRKELSQYIS-LNDN------------HISIS 266
            + +  H+L+  +E++    NE E K   L K+++   S L D             ++S  
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337

Query: 267  VDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISE- 325
            +  L+   +  +   D++M    +     L     T  ++  +S   + D  S +   E 
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQN-----LERHISTLNIQLSDSKKKLQDFASTVEALEE 1392

Query: 326  ----IQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRG- 380
                 QK  + L Q   EKA     L++++ +L+     L    +   +L  ++   +  
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRK 1452

Query: 381  ----LQSSKELKAELDGEKGRDSGEEAHDYEVDINGL-----EILECKYRVAVTEVIDLK 431
                L   K + ++   E+ R   E A + E     L     E LE K  +  T  + LK
Sbjct: 1453 FDQLLAEEKNISSKYADERDRAEAE-AREKETKALSLARALEEALEAKEELERTNKM-LK 1510

Query: 432  AEIKAL---KEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQ 488
            AE++ L   K+   K+V      K   E++++    Q+  LE   + + +    +E  +Q
Sbjct: 1511 AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570

Query: 489  KMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGS 548
               ++  +    L    ++      +L +  H       ET    + D  +Q  +  +  
Sbjct: 1571 ---ALKGQFERDLQARDEQNEEKRRQLQRQLHEY-----ETE---LEDERKQRALAAAAK 1619

Query: 549  LKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPP 608
             K   D + L                   ++   K   EA K+            + A  
Sbjct: 1620 KKLEGDLKDL----------------ELQADSAIKGREEAIKQLRK---------LQAQM 1654

Query: 609  SSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKE 668
                 +  D R     I+   A  ++  K  +      +QL    AAA       D +KE
Sbjct: 1655 KDFQRELEDARASRDEIF---ATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711

Query: 669  ALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKA---------- 718
             L EE   L S LS         R  L+  K+  E  +A L+ + E E+           
Sbjct: 1712 ELAEE---LASSLSG--------RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760

Query: 719  MVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNT 778
              T+   +L NEL   +  A    S R     +  E  ++L EM+   A     K T+  
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG--AVKSKFKSTI-- 1816

Query: 779  LLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKIVSSLL 826
                      AL  ++  LE   EQ  R K    KS     K +  +L
Sbjct: 1817 ---------AALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEIL 1855



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 112/544 (20%), Positives = 214/544 (39%), Gaps = 85/544 (15%)

Query: 13   YKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ---ELEQL 69
            ++ EIE LT++  E      +AA Y  +  + K  L+Q+ D+L  + D+ +Q    LE+ 
Sbjct: 1397 FQKEIENLTQQYEE------KAAAYDKLE-KTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449

Query: 70   KEAFGQSFSIHRKVAE---DGETREETLLQESASKE---AYYLGKILEMQNELKQSRAVV 123
            +  F Q  +  + ++    D   R E   +E  +K    A  L + LE + EL+++  + 
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM- 1508

Query: 124  TNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQ 183
              ++AE E L +   D+ +N   +E  +  ++ ++ E K +   L  +    E+  + L+
Sbjct: 1509 --LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566

Query: 184  KLVSTLK------------QNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQL 231
              +  LK            QN+ +   L+ ++  +E E      Q   A   K+  E  L
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626

Query: 232  --------------EEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGS 277
                          EEA++ L+  + Q  + ++EL    +  D   + + +  K A+   
Sbjct: 1627 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS-- 1684

Query: 278  EPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVE 337
                       +   L++L  D     L   E     +DL  E    E+         ++
Sbjct: 1685 -----------LEADLMQLQED-----LAAAERARKQADLEKEELAEELASSLSGRNALQ 1728

Query: 338  REKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGR 397
             EK  L A + + + +LE  +G +    +RV + T         Q +++L  EL  E+  
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT---------QQAEQLSNELATERST 1779

Query: 398  DSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDE------ 451
                E+   +++    E+    + +        K+ I AL+ K  +  E    E      
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1839

Query: 452  -------KAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTA 504
                   K K   +I +  E    + +  KE  EK     K+L++    A E    +N  
Sbjct: 1840 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899

Query: 505  QDEL 508
            + +L
Sbjct: 1900 RRKL 1903



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 73/408 (17%), Positives = 177/408 (43%), Gaps = 28/408 (6%)

Query: 2    AAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDS 61
            A EE L+  +  +   + L  E+ +    K    +    + + K  L+ Q +E++ + + 
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550

Query: 62   LKQELEQLKEAFGQ----SFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELK 117
            L+ EL+  ++A  +      ++  +   D + R+E    ++  K      ++ E + EL+
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDE----QNEEKRRQLQRQLHEYETELE 1606

Query: 118  QSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDE-IREYKFREARLLQDYTELE 176
              R       A  ++L   ++DL    E+     I+ ++E I++ +  +A++     ELE
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDL----ELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662

Query: 177  EENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALE 236
            +   +  ++ +T K+N+ + + L+ ++ + +E+        + A   KE    +L  +L 
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722

Query: 237  TLKNEREQKNNLRKELSQY---ISLNDNHISISVDGLKFAEDGSEPNNDD--------KM 285
                 +++K  L   ++Q    +     ++    D ++ A   +E  +++        + 
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782

Query: 286  NGHIHGPLVKLNGDYRTPTLR-KGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILL 344
            N      L + N + R+     +G   +      + L  ++I +L++Q+ Q  REK    
Sbjct: 1783 NESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE-AKIAQLEEQVEQEAREKQAAT 1841

Query: 345  ANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELD 392
             +L++   +L+     + ++ +   +  E   A +G    K+LK +L+
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKE--QAEKGNARVKQLKRQLE 1887



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 45/171 (26%), Positives = 73/171 (42%), Gaps = 8/171 (4%)

Query: 645 RSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKR--EQIATLRAVLKANKQTA 702
           R  QL+  +   R  A  +            K+K LL   R  E++      L+  K+  
Sbjct: 809 RQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQ 868

Query: 703 EVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEM 762
           + A   LK + E + + +TE    L+ +L+A  E  A    +R   A +  E    L EM
Sbjct: 869 QKAENELK-ELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927

Query: 763 QRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGK 813
           + +L   ED  + L    +   QQ L L ++LE+     E++ R K +L K
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-----EEAARQKLQLEK 973



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 64/255 (25%), Positives = 109/255 (42%), Gaps = 33/255 (12%)

Query: 48   LKQQYDELEAEYDSLKQ---ELEQLKEAFGQSFSIHRKVAEDGETR--------EETLLQ 96
            L Q  ++L A   + KQ   E E+L E    S S  R   +D + R        EE L +
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLS-GRNALQDEKRRLEARIAQLEEELEE 1747

Query: 97   ESASKEAYY--LGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRM 154
            E  + EA    + K  +   +L    A   +   +NE   +  Q L+  N+ +  +   M
Sbjct: 1748 EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE---SARQQLERQNKELRSKLHEM 1804

Query: 155  KDEIREYKFR------EARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEE 208
            +  ++  KF+      EA++ Q   ++E+E    Q    +LKQ   +   LK  + + E+
Sbjct: 1805 EGAVKS-KFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKK---LKEILLQVED 1860

Query: 209  ETVLLNSQLEDA----IRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHIS 264
            E  +     E A     R+K++ + QLEEA E  +     +  L++EL +    N+  + 
Sbjct: 1861 ERKMAEQYKEQAEKGNARVKQL-KRQLEEAEEESQRINANRRKLQRELDEATESNE-AMG 1918

Query: 265  ISVDGLKFAEDGSEP 279
              V+ LK    G  P
Sbjct: 1919 REVNALKSKLRGPPP 1933


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  101 bits (251), Expect = 3e-21
 Identities = 170/826 (20%), Positives = 324/826 (39%), Gaps = 121/826 (14%)

Query: 13   YKTEIERLTKELTETTHEKIQAAEYGL-----------VVLEEKLTLKQQYDELEAEYDS 61
            + + +++L   L E T E  +A +  L             L++K  L+++ + L+ +   
Sbjct: 330  FASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQ 389

Query: 62   LKQELEQLK--------EAFGQSFSIHRKVAEDG---------ETREETLLQESASKEAY 104
            L++ L QL+        E  G    +     E           + R E L  E   +EA 
Sbjct: 390  LEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAK 449

Query: 105  YLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEM----VELQRIRMKDEIRE 160
             L +    + E +Q  +++T++Q+    L+   ++L++ ++     +  Q   +  E+  
Sbjct: 450  LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTT 509

Query: 161  YKFREARLLQDYTELEEENITLQ-KLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLED 219
                  +  Q+   L+++    Q +L  TL+Q +   +GL+H++++          QL++
Sbjct: 510  LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569

Query: 220  AIRLKEIAEHQLEEALETLKNERE-----------QKNNLRKELSQYISLNDNHISISVD 268
                +E       + L T   ERE           Q   L KE +  + +    + ++ +
Sbjct: 570  VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629

Query: 269  GLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQK 328
                A+        +K    +   + +L     T    + E+   V++L  EL +   Q+
Sbjct: 630  ARDSAQTSVTQAQREK--AELSRKVEELQACVETARQEQHEAQAQVAEL--ELQLRSEQQ 685

Query: 329  LKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERV-HRLTEHVNAMRGLQSS--- 384
               +  +V +EK  L   LQ  +  L+ TKG+L E+  R    L E    +  L++    
Sbjct: 686  KATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRS 745

Query: 385  ---------KELKAELDGEKGRDSG----EEAHDYEVDINGLEILECK--YRVAVTEVID 429
                     KEL+ E  G KG ++      EAH  E ++   E+ E       A +E   
Sbjct: 746  LVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQ 805

Query: 430  LKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQK 489
            L  E+ A +E+Y    E+   E+A+Y +   M+ EQ+ +L++  +++ ++   +++  +K
Sbjct: 806  LVKEVAAWRERY----EDSQQEEAQYGA---MFQEQLMTLKEECEKARQE---LQEAKEK 855

Query: 490  MTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSL 549
            +  I + +   ++  Q+EL      LA+    V                 Q +  R+  L
Sbjct: 856  VAGIESHSELQISRQQNELAELHANLARALQQV-----------------QEKEVRAQKL 898

Query: 550  KGPDDPRGLLSPRLARRGVSSPVET--RTSSEPVAKESTEASKEPSPTKTPTISPVITAP 607
               DD   L     A     + +ET  R + E     S E  KEP+            A 
Sbjct: 899  --ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPA-----------RAG 945

Query: 608  PSSPV-LDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKD 666
               P  L+    R+       L A+ R+       A     +L R RAA  E      ++
Sbjct: 946  DRQPEWLEEQQGRQFCSTQAALQAMERE-------AEQMGNELERLRAALMESQGQQQEE 998

Query: 667  KEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTK 726
            +     E+ +    L+ +R +     A+ KA +   E+ L N  N+   E A + E +  
Sbjct: 999  RGQQEREVAR----LTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAH 1054

Query: 727  LRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDE 772
               E +   ++ A    L A      +E    + +++ QLA  E E
Sbjct: 1055 ALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE 1100



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 130/656 (19%), Positives = 272/656 (41%), Gaps = 99/656 (15%)

Query: 175 LEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQ---- 230
           LE   + L K+   L  +         + ++FE +      Q E A+ LK + +H+    
Sbjct: 88  LEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKI-----QAELAVILKFVLDHEDGLN 142

Query: 231 LEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIH 290
           L E LE    +    +       + +S   +     +  L+  +  S  + ++ ++G   
Sbjct: 143 LNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPA 202

Query: 291 GPLVKLNGDY-RTPTLRKGESLNPVSDLFS-----ELNISEIQKL-----KQQLMQVERE 339
            P+    GD  +TP  +       ++D  S     EL ++E +KL      Q  M  +R 
Sbjct: 203 SPM----GDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRI 258

Query: 340 KAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVN-AMRGLQSSKELKAELDGEKGRD 398
             + L N +++ + LE  +  L E  ++   LT  ++  ++  Q  K  K+++D  K   
Sbjct: 259 DRLALLNEKQAASPLEPKE--LEELRDKNESLTMRLHETLKQCQDLKTEKSQMD-RKINQ 315

Query: 399 SGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESK 458
             EE  D          L  K R   + +  L+  +  L E+++K+ + + +++A+ E +
Sbjct: 316 LSEENGD----------LSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKE 365

Query: 459 IQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQL 518
           +    +    LE+  +    K++ +E+ L ++     +    +     +L T  +E A L
Sbjct: 366 LSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATL 425

Query: 519 YHHVCLCNNETPNRV-MLDYYRQSRVTRSGSLKGP-DDPRGLLSPRLARRGVSSPVETRT 576
             +    N +   RV ML+  R  +  +  + +G  ++ +  LS  +      + +++  
Sbjct: 426 AAN----NTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLI------TDLQSSI 475

Query: 577 SSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQI 636
           S+   AKE  E + +    +                  T+ +      +  LNA I+ Q 
Sbjct: 476 SNLSQAKEELEQASQAHGARL-----------------TAQVASLTSELTTLNATIQQQD 518

Query: 637 KHL----QKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLR 692
           + L    Q+A ++  QL+ Q    +E A       + L  ++ +L S L  K +Q   L+
Sbjct: 519 QELAGLKQQAKEKQAQLA-QTLQQQEQA------SQGLRHQVEQLSSSLKQKEQQ---LK 568

Query: 693 AVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRC 752
            V +  + T +     L    E  +A + E    L+ +L+AL+++ A             
Sbjct: 569 EVAEKQEATRQDHAQQLATAAEEREASLRERDAALK-QLEALEKEKAA------------ 615

Query: 753 DEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSK 808
                +L+ +Q+QL  A + + +  T +  A ++K  L++++E+L+   E +R+ +
Sbjct: 616 -----KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQ 666



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 142/754 (18%), Positives = 294/754 (38%), Gaps = 73/754 (9%)

Query: 79  IHRKVAEDGETREETLLQESASKEAYYL--GKILEMQNELKQSRAVVTNVQAENERLTAV 136
           + +++A++   R+E  L+ + +++       +I  MQ  + +  A++   QA +      
Sbjct: 219 LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRL-ALLNEKQAASPLEPKE 277

Query: 137 VQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEEN----ITLQKLVSTLKQN 192
           +++L++ NE + ++      + ++ K  ++++ +   +L EEN      L++  S L+Q 
Sbjct: 278 LEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQL 337

Query: 193 QVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKEL 252
           Q     L  E  +  +E +   +QL          E +L  AL+  K   E+   L+ +L
Sbjct: 338 QDALNELTEEHSKATQEWLEKQAQL----------EKELSAALQDKKCLEEKNEILQGKL 387

Query: 253 SQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVK---LNGDYRTPTLRKGE 309
           SQ     + H+S   D            N  +  G + G +++   L  +  T      +
Sbjct: 388 SQL----EEHLSQLQD------------NPPQEKGEVLGDVLQLETLKQEAATLAANNTQ 431

Query: 310 SLNPVSDLFSELNISEIQKLKQQ--LMQVEREKAILLANLQESQTQLEHTKGALTEQHER 367
               V  L +E    E + L ++    + +++ + L+ +LQ S + L   K  L EQ  +
Sbjct: 432 LQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEEL-EQASQ 490

Query: 368 VH--RLTEHVNAMRG--------LQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILE 417
            H  RLT  V ++          +Q   +  A L  +      + A   +      + L 
Sbjct: 491 AHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLR 550

Query: 418 CKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKA----KYESKIQMYDEQVTSLEKTT 473
            +     + +   + ++K + EK   + +++  + A    + E+ ++  D  +  LE   
Sbjct: 551 HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALE 610

Query: 474 KESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRV 533
           KE   K+  ++++LQ      +   +++  AQ E    S ++ +L   V     E     
Sbjct: 611 KEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQE----- 665

Query: 534 MLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARR--GVSSPVETRTSSEPVAKESTEASKE 591
              +  Q++V         +  +     R+A+    +   ++    S  V K S E  K 
Sbjct: 666 --QHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR 723

Query: 592 PSPTKTPTISPVIT---APPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQ 648
            +          I+   A   S V      RKE          +  +++ L +A     +
Sbjct: 724 RAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783

Query: 649 -LSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAV-------LKANKQ 700
            L R+ A A       + + E L++E+   +      +++ A   A+       LK   +
Sbjct: 784 VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE 843

Query: 701 TAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLD 760
            A   L   K K    ++     +++ +NEL  L  + A           R  +    L 
Sbjct: 844 KARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903

Query: 761 EMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRL 794
            +Q ++AA   E   L TL+R A +Q+   ++ L
Sbjct: 904 TLQEKMAATSKEVARLETLVRKAGEQQETASREL 937



 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 115/554 (20%), Positives = 223/554 (40%), Gaps = 62/554 (11%)

Query: 4    EEVLQTVDHYKTEIERLTKE-------------LTETTHEKIQAAEYGLVVLEEKLTLKQ 50
            EE+ QTV   K ++ +  KE              TE T  K++A    +  LE++   +Q
Sbjct: 1081 EELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQ 1140

Query: 51   -QYDELE----------AEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETRE----ETLL 95
             Q D LE          AE DS  + L+   E   Q    H + A     RE     T +
Sbjct: 1141 EQADSLERSLEAERASRAERDSALETLQGQLEEKAQELG-HSQSALASAQRELAAFRTKV 1199

Query: 96   QESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMK 155
            Q+ +  E  +  ++   + E ++  +++++++ E   L   V  L++  E  EL+R+ M 
Sbjct: 1200 QDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQV--LEKEGESKELKRLVMA 1257

Query: 156  DEIREYKFREA-RLLQDYT-----ELEEENITLQKLVSTLKQN----QVEYEGLKHEIKR 205
            +  +  K  E  RLLQ  T        E +  L++ V +L++     +V  E L+ E+  
Sbjct: 1258 ESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTS 1317

Query: 206  FEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISI 265
              E    L  +L    +  +    Q E+AL TL+ E      L  EL     L   H+  
Sbjct: 1318 QAERAEELGQEL----KAWQEKFFQKEQALSTLQLEHTSTQALVSEL-----LPAKHLC- 1367

Query: 266  SVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISE 325
                L+  +  +E  + +++            G  R   LR    L  +  L  +  ++E
Sbjct: 1368 --QQLQAEQAAAEKRHREELEQSKQAA-----GGLRAELLRAQRELGELIPLRQK--VAE 1418

Query: 326  IQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSK 385
             ++  QQL   +   A  L+ L+++   L      L E+     +  E V   +  +   
Sbjct: 1419 QERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLE-VELDQAREKYV 1477

Query: 386  ELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSV 445
            +  A +  +      E   + +     LE++  KY  A  +V++ +   +  ++K    V
Sbjct: 1478 QELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQV 1537

Query: 446  ENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQ 505
            E     + +   +++   +++   ++ +K   +K+  ++ +  +    A    + LN  Q
Sbjct: 1538 EQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQ 1597

Query: 506  DELVTFSEELAQLY 519
             +L +  E+ A+ Y
Sbjct: 1598 AQL-SQKEQAAEHY 1610



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 163/845 (19%), Positives = 315/845 (37%), Gaps = 173/845 (20%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLK 63
            +E L T+   K E E+  +EL E   EK+   E        +L + +Q +EL   + +L 
Sbjct: 832  QEQLMTL---KEECEKARQELQEAK-EKVAGIES-----HSELQISRQQNELAELHANLA 882

Query: 64   QELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQ--SRA 121
            + L+Q++E   ++    +K+A+D  T +E +   + SKE   L  ++    E ++  SR 
Sbjct: 883  RALQQVQEKEVRA----QKLADDLSTLQEKMA--ATSKEVARLETLVRKAGEQQETASRE 936

Query: 122  VVTNVQAENER---------------LTAVVQDLKENNEMV--ELQRIR--------MKD 156
            +V       +R                 A +Q ++   E +  EL+R+R         + 
Sbjct: 937  LVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQ 996

Query: 157  EIREYKFREARLLQDYTELEEENITLQK---------LVSTLKQNQVEYEGLKHEIKRFE 207
            E R  + RE   L       + ++ L+K         L + L + +VE+  L+  +    
Sbjct: 997  EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHAL 1056

Query: 208  EETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISV 267
             E    + +L     L+     +LEE  +T+K  +EQ     KE                
Sbjct: 1057 TEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE---------------- 1100

Query: 268  DGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRT-PTLRKGESLNPVSDLFSELNISEI 326
                                H  G   +     RT PT   G  L  +    S+L   + 
Sbjct: 1101 --------------------HASGSGAQSEAAGRTEPT---GPKLEALRAEVSKLE-QQC 1136

Query: 327  QKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERV-HRLTEHVNAMRGL---- 381
            QK ++Q   +ER      A+  E  + LE  +G L E+ + + H  +   +A R L    
Sbjct: 1137 QKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFR 1196

Query: 382  -------QSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEI 434
                   ++  E KA++   +GR   E  +        +  LE +  +   +V++ + E 
Sbjct: 1197 TKVQDHSKAEDEWKAQV--ARGRQEAERKNSL------ISSLEEEVSILNRQVLEKEGES 1248

Query: 435  KALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIA 494
            K LK    + V   +++  K E ++++   +  S    +  + E+ + + +E+Q +   A
Sbjct: 1249 KELK----RLVMAESEKSQKLEERLRLLQAETAS---NSARAAERSSALREEVQSLREEA 1301

Query: 495  NENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDD 554
             +        + EL + +E   +L   +         +   + + Q     S        
Sbjct: 1302 EKQRVASENLRQELTSQAERAEELGQEL---------KAWQEKFFQKEQALSTLQLEHTS 1352

Query: 555  PRGLLSPRLARRGVSSPVET-RTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVL 613
             + L+S  L  + +   ++  + ++E   +E  E SK+ +                    
Sbjct: 1353 TQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAA-------------------- 1392

Query: 614  DTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEE 673
                              +R ++   Q+ +   + L ++ A     A  +  +K +  E+
Sbjct: 1393 ----------------GGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQ 1436

Query: 674  ILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMV-TETMTKLRNELK 732
            +  LK       E+   L       +Q  EV L   + KY  E A V  +  T+L    +
Sbjct: 1437 LSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRL---AE 1493

Query: 733  ALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQ 792
              +E  +T   L  M A      V  L+E QR     ++E++ L   +      +   T+
Sbjct: 1494 VQREAQSTARELEVMTAKYEGAKVKVLEERQR----FQEERQKLTAQVEQLEVFQREQTK 1549

Query: 793  RLEDL 797
            ++E+L
Sbjct: 1550 QVEEL 1554



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 152/778 (19%), Positives = 298/778 (38%), Gaps = 135/778 (17%)

Query: 7    LQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQEL 66
            ++T    + E +    EL      + Q A     V +EK  L++Q   L+      K  L
Sbjct: 659  VETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSL 718

Query: 67   EQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNV 126
            E+ K     +    ++   + +    +L+++   +           + EL++ RA    +
Sbjct: 719  EEEKRRAADALEEQQRCISELKAETRSLVEQHKRE-----------RKELEEERAGRKGL 767

Query: 127  QAENERLTAVVQDLKE--NNEMVELQRIRMKDE------IREYKFREARLLQDYTELEEE 178
            +A  ++L    Q   E    E+ E    +   E      ++E      R      E  + 
Sbjct: 768  EARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQY 827

Query: 179  NITLQKLVSTLKQNQVEYEGLKHEIKRFEEET--VLLNSQLEDAIRLKEIAE--HQLEEA 234
                Q+ + TLK+   E E  + E++  +E+   +  +S+L+ + +  E+AE    L  A
Sbjct: 828  GAMFQEQLMTLKE---ECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARA 884

Query: 235  LETLKNEREQKNNLRKELS---QYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHG 291
            L+ ++ +  +   L  +LS   + ++     ++     ++ A +  E  + + +      
Sbjct: 885  LQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARA 944

Query: 292  PLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQ 351
                  GD +   L + +     S        + +Q ++++  Q+  E   L A L ESQ
Sbjct: 945  ------GDRQPEWLEEQQGRQFCS------TQAALQAMEREAEQMGNELERLRAALMESQ 992

Query: 352  TQLEHTKGALTEQHERVHRLT-EHVNAMRGLQSSKELKAELDGEKGRDSGE--------- 401
             Q +  +G   +Q   V RLT E   A   L   K  +AEL+        E         
Sbjct: 993  GQQQEERG---QQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQ 1049

Query: 402  ----------EAHDYEV-DINGLEILECKYRVAVTEVIDLKAEIKALKEKY-NKSVENYT 449
                      E  D E+  + GLE  + K      E+ +L+  +K LKE+   K  E+ +
Sbjct: 1050 EALAHALTEKEGKDQELAKLRGLEAAQIK------ELEELRQTVKQLKEQLAKKEKEHAS 1103

Query: 450  DEKAKYES---------KIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHST 500
               A+ E+         K++    +V+ LE+  ++  E+   +E+ L+   +   E  S 
Sbjct: 1104 GSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSA 1163

Query: 501  LNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLS 560
            L T Q +L    EE AQ   H                                    L S
Sbjct: 1164 LETLQGQL----EEKAQELGH--------------------------------SQSALAS 1187

Query: 561  PRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRK 620
             +       + V+  + +E   K      ++ +  K   IS   +      +L+   + K
Sbjct: 1188 AQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS---SLEEEVSILNRQVLEK 1244

Query: 621  EPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAA----ARELAPMIDKDKEALMEEILK 676
            E  +   L  ++  + +  QK  +R   L  + A+    A E +  + ++ ++L EE  K
Sbjct: 1245 EGES-KELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEK 1303

Query: 677  -------LKSLLSTKREQIATLRAVLKANKQ---TAEVALANLKNKYENEKAMVTETM 724
                   L+  L+++ E+   L   LKA ++     E AL+ L+ ++ + +A+V+E +
Sbjct: 1304 QRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELL 1361



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 56/274 (20%), Positives = 119/274 (43%), Gaps = 47/274 (17%)

Query: 14   KTEIERLTKELTETTHE-KIQAAEYG---LVVLEEKLTLKQQYDELEAEYDSLKQ-ELEQ 68
            +T +  + +E   T  E ++  A+Y    + VLEE+   +++  +L A+ + L+  + EQ
Sbjct: 1488 ETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQ 1547

Query: 69   LKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQA 128
             K    Q   + +K+A+  +  +   +Q+   K     G   E Q E ++ +A +  +QA
Sbjct: 1548 TK----QVEELSKKLADSDQASK---VQQQKLKAVQAQGG--ESQQEAQRLQAQLNELQA 1598

Query: 129  ENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVST 188
            +          L +  +  E  +++M+     Y  ++    Q   EL+E+  +L++L   
Sbjct: 1599 Q----------LSQKEQAAEHYKLQMEKAKTHYDAKK----QQNQELQEQLRSLEQLQKE 1644

Query: 189  LKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNL 248
             K+ + E E L HE+    ++  L   + E   R        L   + +L+ +    +  
Sbjct: 1645 NKELRAEAERLGHEL----QQAGLKTKEAEQTCR-------HLTAQVRSLEAQVAHADQQ 1693

Query: 249  RKELSQYISLNDNHISISVDGLKFAEDGSEPNND 282
             ++L ++         ++ D LK  E  ++P  D
Sbjct: 1694 LRDLGKF--------QVATDALKSREPQAKPQLD 1719


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  100 bits (248), Expect = 7e-21
 Identities = 152/782 (19%), Positives = 302/782 (38%), Gaps = 121/782 (15%)

Query: 92   ETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQR 151
            E  L E  + ++  + + L++Q +L+    +    +    RLTA  Q+L+E    +E + 
Sbjct: 865  ENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARV 924

Query: 152  IRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETV 211
               ++  +  +  + ++ Q+  ELEE+   L++  S  ++ Q+E    + ++K+ EEE +
Sbjct: 925  EEEEERCQHLQAEKKKMQQNIQELEEQ---LEEEESARQKLQLEKVTTEAKLKKLEEEQI 981

Query: 212  LLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLK 271
            +L  Q     + K++ E ++ E    L  E E+  +L K       L + H ++  D   
Sbjct: 982  ILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK-------LKNKHEAMITD--- 1031

Query: 272  FAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQ 331
              E+      ++K    +     KL GD              +SD  +EL  ++I +LK 
Sbjct: 1032 -LEE--RLRREEKQRQELEKTRRKLEGD-----------STDLSDQIAELQ-AQIAELKM 1076

Query: 332  QLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKE----- 386
            QL + E E    LA ++E   Q       + E   ++  L E + + R  ++  E     
Sbjct: 1077 QLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRD 1136

Query: 387  -------LKAELDGEKGRDSG--------------------EEAHDYEVDINGLEILECK 419
                   LK EL+      +                     EEA  +E  I  +     +
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ 1196

Query: 420  YRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKA------------------KYESKIQM 461
                + E ++    +KA  EK  +++EN   E A                  K E+++Q 
Sbjct: 1197 AVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE 1256

Query: 462  YDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHH 521
               +    E+   E  +K+  ++ EL  +T + +++ S  +    +      +L      
Sbjct: 1257 LQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD---- 1312

Query: 522  VCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRL-----ARRGVSSPVETRT 576
                      + +L    + +++ S  LK  +D +     +L     A+  +   + T  
Sbjct: 1313 ---------TQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH 1363

Query: 577  SSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQI 636
            +     K+  E S     T     +  +       +   S   +E +  Y  + + + + 
Sbjct: 1364 AQVADMKKKMEDSVGCLET-----AEEVKRKLQKDLEGLSQRHEEKVAAY--DKLEKTKT 1416

Query: 637  KHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLK 696
            +  Q+  D  + L  QR +A  L     + K+   +++L  +  +S K  +         
Sbjct: 1417 RLQQELDDLLVDLDHQRQSACNL-----EKKQKKFDQLLAEEKTISAKYAEERDRAEAEA 1471

Query: 697  ANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKAL---KEDAA----TFSSLRAMFA 749
              K+T  ++LA    +   +KA +     + R E++ L   K+D           +    
Sbjct: 1472 REKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALE 1531

Query: 750  TRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKG 809
             + +E  TQL+E++ +L A ED K      LR+ +  +    Q   DL+   EQS   K 
Sbjct: 1532 QQVEEMKTQLEELEDELQATEDAK------LRLEVNLQAMKAQFERDLQGRDEQSEEKKK 1585

Query: 810  KL 811
            +L
Sbjct: 1586 QL 1587



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 172/833 (20%), Positives = 333/833 (39%), Gaps = 123/833 (14%)

Query: 8    QTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELE 67
            + ++  KTE+E  T + T    E     E  + +L  K TL+++    EA+   ++Q+  
Sbjct: 1139 EELEALKTELED-TLDSTAAQQELRSKREQEVNIL--KKTLEEEAKTHEAQIQEMRQKHS 1195

Query: 68   QLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQ 127
            Q  E   +     ++V  + E  ++TL  E             E+ NE+K       + +
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERG-----------ELANEVKVLLQGKGDSE 1244

Query: 128  AENERLTAVVQDLKENNEMVELQRIRMKDEIREYKF--------------REARLLQDYT 173
             + +++ A +Q+L+      E  R  + D++ + +               + ++L +D++
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304

Query: 174  ELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEE 233
             LE +   LQ     L++   +   L  ++K+ E+E      QLE+    +E A+H LE+
Sbjct: 1305 ALESQ---LQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE----EEEAKHNLEK 1357

Query: 234  ALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPL 293
             + TL     Q  +++K++   +   +    +     K  E G    +++K+  +     
Sbjct: 1358 QIATL---HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE-GLSQRHEEKVAAYD---- 1409

Query: 294  VKLNGDYRTPTLRKGESLNPVSDLF----SELNISEIQKLKQQLMQVER--------EKA 341
             KL    +T T  + E  + + DL     S  N+ + QK   QL+  E+        E+ 
Sbjct: 1410 -KLE---KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERD 1465

Query: 342  ILLANLQESQTQLEHTKGALTEQHER---VHRLTEHVNA-MRGLQSSKELKAELDGEKGR 397
               A  +E +T+      AL E  E+   + RL +     M  L SSK+           
Sbjct: 1466 RAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKD----------- 1514

Query: 398  DSGEEAHDYEVDINGLE--ILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKY 455
            D G+  H+ E     LE  + E K     T++ +L+ E++A ++   +   N    KA++
Sbjct: 1515 DVGKSVHELEKSKRALEQQVEEMK-----TQLEELEDELQATEDAKLRLEVNLQAMKAQF 1569

Query: 456  ESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEEL 515
            E  +Q  DEQ          S EK   + +++++M +   +     + A         +L
Sbjct: 1570 ERDLQGRDEQ----------SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDL 1619

Query: 516  AQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETR 575
              L  H+   N      +     R+ +      ++  DD R      LA+   +      
Sbjct: 1620 KDLEAHIDSANKNRDEAIK--QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS 1677

Query: 576  TSSEPVAKE----STEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNA- 630
              +E +  +    + E +K  +  +   ++  I        L   + R+    I  L   
Sbjct: 1678 MEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEE 1737

Query: 631  ---------IIRDQIKHLQKAVDR---SLQLSRQRAAARELAPMIDKDKEALMEEILKLK 678
                     +I D++K     +D+    L L R  A   E A      ++ L  +  +LK
Sbjct: 1738 LEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENA------RQQLERQNKELK 1791

Query: 679  SLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDA 738
              L   +E   T+++  KA+    E  +A L+ + +NE         ++R   K LK+  
Sbjct: 1792 VKL---QEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVL 1848

Query: 739  ATFSSLR---AMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKL 788
                  R     +  + D+  T+L +++RQL  AE+E +  N   R  +Q++L
Sbjct: 1849 LQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANA-SRRKLQREL 1900



 Score = 87.4 bits (215), Expect = 5e-17
 Identities = 184/865 (21%), Positives = 343/865 (39%), Gaps = 136/865 (15%)

Query: 1    MAAEEVLQTV-------DHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYD 53
            MA EE L  V       ++  TE+E L  +L     EK+Q  E     L+ +  L  + +
Sbjct: 848  MAKEEELVKVREKQLAAENRLTEMETLQSQLMA---EKLQLQEQ----LQAETELCAEAE 900

Query: 54   ELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQ 113
            EL A   + KQELE++         +  +V E     EE   Q   +++      I E++
Sbjct: 901  ELRARLTAKKQELEEI------CHDLEARVEE-----EEERCQHLQAEKKKMQQNIQELE 949

Query: 114  NELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYT 173
             +L++  +    +Q E     A ++ L+E   ++E Q  ++  E +  + R A    + T
Sbjct: 950  EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT 1009

Query: 174  ELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEE 233
            E EE++ +L KL +            KHE          + + LE+ +R +E    +LE+
Sbjct: 1010 EEEEKSKSLAKLKN------------KHE---------AMITDLEERLRREEKQRQELEK 1048

Query: 234  ALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFA-----EDGSEPNNDDKMNGH 288
                L+ +    ++   EL   I+     ++   + L+ A     E+ ++ N   K    
Sbjct: 1049 TRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE 1108

Query: 289  IHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQ-------KLKQQLMQVEREKA 341
            +   + +L  D  +    + ++     DL  EL   + +          QQ ++ +RE+ 
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQE 1168

Query: 342  --ILLANLQESQTQLEHTKGALTEQH-ERVHRLTEHVNAMRGLQSSKELKAELDGEK--- 395
              IL   L+E     E     + ++H + V  L E       L+ +K +KA L+  K   
Sbjct: 1169 VNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ------LEQTKRVKANLEKAKQTL 1222

Query: 396  GRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKY 455
              + GE A++ +V + G    E K +        ++A+++ L+ K+N+  E    E A  
Sbjct: 1223 ENERGELANEVKVLLQGKGDSEHKRK-------KVEAQLQELQVKFNEG-ERVRTELADK 1274

Query: 456  ESKIQMYDEQVTSLEKTTKESGEKM----AHMEKELQKMTSIANENH-------STLNTA 504
             +K+Q+  + VT L   +     K+    + +E +LQ    +  E +       + L   
Sbjct: 1275 VTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQV 1334

Query: 505  QDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLA 564
            +DE  +F E+L +          E  + +                K  D    L +    
Sbjct: 1335 EDEKNSFREQLEE--------EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386

Query: 565  RRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMN 624
            +R +   +E  +      +E   A  +   TKT      +       ++D    R+   N
Sbjct: 1387 KRKLQKDLEGLSQRH---EEKVAAYDKLEKTKTR-----LQQELDDLLVDLDHQRQSACN 1438

Query: 625  IYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEAL-----MEEILKLKS 679
            +        DQ+   +K +       R RA A       +K+ +AL     +EE ++ K+
Sbjct: 1439 LEKKQKKF-DQLLAEEKTISAKYAEERDRAEAEAR----EKETKALSLARALEEAMEQKA 1493

Query: 680  LLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMT---KLRNELKALKE 736
             L    +Q  T    L ++K     ++  L+      +  V E  T   +L +EL+A  E
Sbjct: 1494 ELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQA-TE 1552

Query: 737  DA-----ATFSSLRAMFATRCDEYVTQLDEMQRQL--------AAAEDEKKTLNTLLRMA 783
            DA         +++A F         Q +E ++QL        A  EDE+K  +    MA
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRS----MA 1608

Query: 784  IQQKLALTQRLEDLEFDHEQSRRSK 808
            +  +  L   L+DLE   + + +++
Sbjct: 1609 VAARKKLEMDLKDLEAHIDSANKNR 1633



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 95/526 (18%), Positives = 212/526 (40%), Gaps = 101/526 (19%)

Query: 1    MAAEEVLQTVDHYKTEIERLTKEL-TETTHEKIQAAEYGLVVLE---EKLTLKQQYDELE 56
            ++    L+     K E+ERL K+  TE         + G  V E    K  L+QQ +E++
Sbjct: 1479 LSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMK 1538

Query: 57   AEYDSLKQELEQLKEA-FGQSFSIHRKVAE---DGETREETLLQESASKEAYYLGKILEM 112
             + + L+ EL+  ++A      ++    A+   D + R+E    +S  K+   + ++ EM
Sbjct: 1539 TQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDE----QSEEKKKQLVRQVREM 1594

Query: 113  QNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDY 172
            + EL+  R   +   A  ++L   ++DL+ + +     R    + I++ +  +A++    
Sbjct: 1595 EAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR---DEAIKQLRKLQAQMKDCM 1651

Query: 173  TELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLE 232
             EL++   + +++++  K+N+        ++K  E E + L  +L  A R K  A+ + +
Sbjct: 1652 RELDDTRASREEILAQAKENE-------KKLKSMEAEMIQLQEELAAAERAKRQAQQERD 1704

Query: 233  EALETLKNER-------EQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKM 285
            E  + + N         E+K  L   ++Q             + L+  +  +E  ND   
Sbjct: 1705 ELADEIANSSGKGALALEEKRRLEARIAQL-----------EEELEEEQGNTELINDRLK 1753

Query: 286  NGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNI--SEIQKLKQQLMQVEREKAIL 343
              ++                        +  + ++LN+  S  QK +    Q+ER+   L
Sbjct: 1754 KANLQ-----------------------IDQINTDLNLERSHAQKNENARQQLERQNKEL 1790

Query: 344  LANLQESQ-TQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEE 402
               LQE + T     K ++T    ++ +L E ++                         E
Sbjct: 1791 KVKLQEMEGTVKSKYKASITALEAKIAQLEEQLD------------------------NE 1826

Query: 403  AHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMY 462
              + +     +   E K +  + +V D +           ++ E Y D+  K  ++++  
Sbjct: 1827 TKERQAACKQVRRTEKKLKDVLLQVDDER-----------RNAEQYKDQADKASTRLKQL 1875

Query: 463  DEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDEL 508
              Q+   E+  + +      +++EL+  T  A+  +  +++ +++L
Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 55/207 (26%), Positives = 94/207 (45%), Gaps = 21/207 (10%)

Query: 619  RKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLK 678
            +K   NI  L   + ++    QK     LQL +    A+     +++++  L ++  KL 
Sbjct: 939  KKMQQNIQELEEQLEEEESARQK-----LQLEKVTTEAK--LKKLEEEQIILEDQNCKLA 991

Query: 679  SLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDA 738
                   ++IA     L   ++ ++ +LA LKNK+E   AM+T+   +LR E K  +E  
Sbjct: 992  KEKKLLEDRIAEFTTNLTEEEEKSK-SLAKLKNKHE---AMITDLEERLRREEKQRQELE 1047

Query: 739  ATFSSLRAMFATRCD---EYVTQLDEMQRQLAAAEDE-KKTLNTLLRMAIQQKLALTQ-- 792
             T   L        D   E   Q+ E++ QLA  E+E +  L  +   A Q+ +AL +  
Sbjct: 1048 KTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIR 1107

Query: 793  ----RLEDLEFDHEQSRRSKGKLGKSK 815
                ++ +L+ D E  R S+ K  K K
Sbjct: 1108 ELESQISELQEDLESERASRNKAEKQK 1134



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 79/403 (19%), Positives = 165/403 (40%), Gaps = 62/403 (15%)

Query: 424  VTEVIDLKAEIKALKEKYNKSVENYTDE-------KAKYESKIQMYDEQVTSLEKTTKES 476
            +TE+  L++++ A K +  + ++  T+        +A+  +K Q  +E    LE   +E 
Sbjct: 868  LTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEE 927

Query: 477  GEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLD 536
             E+  H++ E +KM              Q  +    E+L +              ++ L+
Sbjct: 928  EERCQHLQAEKKKM--------------QQNIQELEEQLEE--------EESARQKLQLE 965

Query: 537  YYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTK 596
                 +VT    LK  ++ + +L  +  +       E +   + +A+ +T  ++E   +K
Sbjct: 966  -----KVTTEAKLKKLEEEQIILEDQNCKLAK----EKKLLEDRIAEFTTNLTEEEEKSK 1016

Query: 597  TPTISPVITAPPSSPVLDTSD-IRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAA 655
            +      +     + + D  + +R+E      L    R   K    + D S Q++  +A 
Sbjct: 1017 SLA---KLKNKHEAMITDLEERLRREEKQRQELEKTRR---KLEGDSTDLSDQIAELQAQ 1070

Query: 656  ARELAPMIDKDKEALMEEILKLKSLLSTKR---EQIATLRAVLKANKQTAEVALANLKNK 712
              EL   + K +E L   + +++   + K    ++I  L + +   ++  E   A+ +NK
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERAS-RNK 1129

Query: 713  YENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDE 772
             E +K  + E +  L+ EL+   +  A    LR+           +  E+       E+E
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK----------REQEVNILKKTLEEE 1179

Query: 773  KKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSK 815
             KT    ++   Q+    +Q +E+L    EQ++R K  L K+K
Sbjct: 1180 AKTHEAQIQEMRQKH---SQAVEELAEQLEQTKRVKANLEKAK 1219



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 55/249 (22%), Positives = 103/249 (41%), Gaps = 25/249 (10%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLK----QQYDELEAEY 59
            +E L   +  K + ++   EL +   E   ++  G + LEEK  L+    Q  +ELE E 
Sbjct: 1686 QEELAAAERAKRQAQQERDELAD---EIANSSGKGALALEEKRRLEARIAQLEEELEEEQ 1742

Query: 60   DSLKQELEQLKEA------FGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQ 113
             + +   ++LK+A           ++ R  A+  E   + L +++   +     K+ EM+
Sbjct: 1743 GNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKV----KLQEME 1798

Query: 114  NELKQS-RAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDY 172
              +K   +A +T ++A+  +L   +     +NE  E Q    +    E K ++  L  D 
Sbjct: 1799 GTVKSKYKASITALEAKIAQLEEQL-----DNETKERQAACKQVRRTEKKLKDVLLQVDD 1853

Query: 173  TELEEENITLQ--KLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQ 230
                 E    Q  K  + LKQ + + E  + E +R       L  +LEDA    +    +
Sbjct: 1854 ERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNRE 1913

Query: 231  LEEALETLK 239
            +      L+
Sbjct: 1914 VSSLKNKLR 1922


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 170/821 (20%), Positives = 316/821 (38%), Gaps = 122/821 (14%)

Query: 46   LTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYY 105
            L + +Q +EL+A+ + L +  E+  +  G+   + RK  +  E  E+ +L E    E   
Sbjct: 845  LQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLE--EKNILAEQLQAETEL 902

Query: 106  LGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFRE 165
              +  EM+  L   +  +  +  +   L + V++ +E N++++ ++ +M+  I++ +   
Sbjct: 903  FAEAEEMRARLAAKKQELEEILHD---LESRVEEEEERNQILQNEKKKMQAHIQDLE--- 956

Query: 166  ARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKE 225
                    +L+EE    QKL       Q+E    + +IK+ EEE +LL  Q    I+ K+
Sbjct: 957  -------EQLDEEEGARQKL-------QLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKK 1002

Query: 226  IAEHQLEEALETLKNEREQKNNLRK-ELSQYISLNDNHISI--------SVDGLKFAEDG 276
            + E ++ E    L  E E+  NL K    Q + ++D    +         ++  K   DG
Sbjct: 1003 LMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062

Query: 277  SEPNNDD-----------------KMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFS 319
               +  D                 K    + G L +  GD    TL K  +L  V +L  
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR--GD--DETLHKNNALKVVREL-- 1116

Query: 320  ELNISEIQK----LKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHV 375
            +  I+E+Q+     K    + E++K  L   L+  +T+LE T      Q E   +  + V
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176

Query: 376  NAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIK 435
                      ELK  L+        EE  ++E  I  +          ++E ++     K
Sbjct: 1177 ---------AELKKALE--------EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK 1219

Query: 436  ALKEKYNKSVENYTDE-----------KAKYESKIQMYDEQVTSLEKTTKESGEKMAHME 484
            A  EK  + +E    E           KA+ E K +  D QV  L     E       + 
Sbjct: 1220 ANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA 1279

Query: 485  KELQKMTSIANENHSTLNTAQDELVTFSEELA----QLYHHVCLCNNETPNRVMLDYYRQ 540
            ++  K+ +  +   + L  A+ + + F+++ A    QL     L   ET  ++ L    +
Sbjct: 1280 EKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIR 1339

Query: 541  SRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKE-STEASKEPSPTKTPT 599
                   SL+   +        L ++ ++   +   + + V  +  T  S E +  K   
Sbjct: 1340 QLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLK 1399

Query: 600  ISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAAREL 659
             +  ++       L    + K    +              Q+  D ++ L  QR  A  L
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQ-------------QELDDLTVDLDHQRQVASNL 1446

Query: 660  APMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALA-------NLKNK 712
                 K  + L EE    KS+ +   E+     A  +  K+T  ++LA         K +
Sbjct: 1447 EKKQKKFDQLLAEE----KSISARYAEERDRAEAEAR-EKETKALSLARALEEALEAKEE 1501

Query: 713  YENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDE 772
            +E +   +   M  L +    + ++       +     + +E  TQL+E++ +L A ED 
Sbjct: 1502 FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDA 1561

Query: 773  KKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGK 813
            K      LR+ +  +    Q   DL+   EQ+   K  L K
Sbjct: 1562 K------LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK 1596



 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 154/826 (18%), Positives = 325/826 (39%), Gaps = 91/826 (11%)

Query: 4    EEVLQTVDHYKTEIERLTKELT-ETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSL 62
            EE L+  +  + E+E+  ++L  ETT  + Q AE    + E KL L ++ +EL+      
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARG 1099

Query: 63   KQELEQLKEAFGQSFSIHRKVAEDGETRE-ETLLQESASKEAYYLGKILE-MQNELKQSR 120
              E      A      +  ++AE  E  E E   +  A K+   L + LE ++ EL+ + 
Sbjct: 1100 DDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDT- 1158

Query: 121  AVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTE------ 174
              +    A+ E  T   Q++ E  + +E +    + +I++ + R A  L++ +E      
Sbjct: 1159 --LDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216

Query: 175  ------------LEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIR 222
                        LE +N  L   V  L+Q + E E   H+ K+ + +   L++++ +  R
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESE---HKRKKLDAQVQELHAKVSEGDR 1273

Query: 223  LKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNND 282
            L+     +L E    L+NE +  + L +E  +              G+KFA+D +     
Sbjct: 1274 LRV----ELAEKASKLQNELDNVSTLLEEAEK-------------KGIKFAKDAAS---- 1312

Query: 283  DKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAI 342
                  +   L       +  T +K    + +  L  E N  + Q+ +++  +   EK +
Sbjct: 1313 ------LESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366

Query: 343  LL--ANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAE-LDGEKGRDS 399
            L   + L +++ +++   G +    E   +L +   A+      K L  + L+  K R  
Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ 1426

Query: 400  GEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKI 459
             +E  D  VD++    +         +   L AE K++  +Y        +E+ + E++ 
Sbjct: 1427 -QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY-------AEERDRAEAEA 1478

Query: 460  QMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLY 519
            +  + +  SL +  +E+ E     E++           +  L    ++L++  +++ +  
Sbjct: 1479 REKETKALSLARALEEALEAKEEFERQ-----------NKQLRADMEDLMSSKDDVGKNV 1527

Query: 520  HHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSE 579
            H +         +V  +  R         L+  +D +  L   +         + +T  E
Sbjct: 1528 HELEKSKRALEQQV--EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDE 1585

Query: 580  PVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAII------R 633
                   E  K     +   +   +        L  +  +K  +++ +L A I      R
Sbjct: 1586 -----QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKAR 1640

Query: 634  DQ-IKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLR 692
            D+ IK L+K   +     R+   AR     I    +   +++  L++ +   +E++A+  
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700

Query: 693  AVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRC 752
               +  +Q  +     + N    + A++ E   +L   +  L+E+     S   +   R 
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKR-RLEARIAQLEEELEEEQSNMELLNDRF 1759

Query: 753  DEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLE 798
             +   Q+D +  +LAA     +  +   +   +Q   L  +L++LE
Sbjct: 1760 RKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELE 1805



 Score = 75.1 bits (183), Expect = 3e-13
 Identities = 157/850 (18%), Positives = 345/850 (40%), Gaps = 113/850 (13%)

Query: 3    AEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSL 62
            AEE+   +   K E+E +  +L     E+           E    L+ +  +++A    L
Sbjct: 906  AEEMRARLAAKKQELEEILHDLESRVEEEE----------ERNQILQNEKKKMQAHIQDL 955

Query: 63   KQELEQLKEAFGQSFSIHRKVAEDG--ETREETLLQESAS----KEAYYL-GKILEMQNE 115
            +++L++ +E   Q   + +  AE    +  EE LL E  +    KE   +  +I E  ++
Sbjct: 956  EEQLDE-EEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQ 1014

Query: 116  LKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQ-DYTE 174
            L +      N+     +   ++ DL+E        R++ +++ R+   +  R L  + T+
Sbjct: 1015 LAEEEEKAKNLAKIRNKQEVMISDLEE--------RLKKEEKTRQELEKAKRKLDGETTD 1066

Query: 175  LEEENITLQKLVSTLK-QNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLK-EIAEHQLE 232
            L+++   LQ  +  LK Q   + E L+  + R ++ET+  N+ L+    L+ +IAE  L+
Sbjct: 1067 LQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE--LQ 1124

Query: 233  EALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDD--KMNGHIH 290
            E  E+ K  R +    +++LS+ +      +  ++D     ++       +  ++   + 
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184

Query: 291  GPLVKLNGDYRTPTLRKGESLNPVSDLFSELNI--SEIQKLKQQLMQVEREKAILLANLQ 348
                      +    R   +L  +S+   +     + ++K KQ L    +E A  +  LQ
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ 1244

Query: 349  ESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEV 408
            + + + EH +  L  Q + +H      + +R   + K  K + + +      EEA     
Sbjct: 1245 QVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK--- 1301

Query: 409  DINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTS 468
               G++  +        +   L+++++  +E     ++  T +K    S+I+  +E+  S
Sbjct: 1302 --KGIKFAK--------DAASLESQLQDTQEL----LQEETRQKLNLSSRIRQLEEEKNS 1347

Query: 469  LEKTTKESGEKMAHMEKELQKMTSIANENHS----------TLNTAQDELVTFSEELAQL 518
            L++  +E  E   ++EK++  + S   +             +L  A+ +L+  +E L+Q 
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR 1407

Query: 519  YHHVCLCNNE---TPNRVM---------LDYYRQSRVTRSGSLKGPDDPRGLLSPRLARR 566
                 L  ++   T NR+          LD+ RQ         K  D    LL+      
Sbjct: 1408 LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ---LLA------ 1458

Query: 567  GVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLD-----TSDIRKE 621
                  E ++ S   A+E   A  E    +T  +S       +    +        +R +
Sbjct: 1459 ------EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRAD 1512

Query: 622  PMNIYNLNAIIRDQIKHLQKAVDRSL--QLSRQRAAARELAPMIDKDKEALMEEILKLKS 679
              ++ +    +   +  L+K+  R+L  Q+   R    EL   +   ++A +   + +++
Sbjct: 1513 MEDLMSSKDDVGKNVHELEKS-KRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQA 1571

Query: 680  LLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEK---AMVTETMTKLRNELKALKE 736
            + +     + T     +  K+     +  L+ + E+E+   A+   +  K+  +LK L+ 
Sbjct: 1572 MKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEA 1631

Query: 737  DAATFSSLRAMFATRCDEYVTQLDEMQRQL-----------AAAEDEKKTLNTLLR--MA 783
                 +  R     +  +   Q+ + QR+L           A +++ +K L +L    + 
Sbjct: 1632 QIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQ 1691

Query: 784  IQQKLALTQR 793
            +Q++LA ++R
Sbjct: 1692 LQEELASSER 1701



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 149/772 (19%), Positives = 303/772 (39%), Gaps = 99/772 (12%)

Query: 18   ERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ----ELEQLKEAF 73
            +R    L E + +  QA  +   + + K  L+    EL  E   L+Q       + K+  
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLD 1258

Query: 74   GQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERL 133
             Q   +H KV+E    R E  L E ASK    L  +  +  E ++         A    L
Sbjct: 1259 AQVQELHAKVSEGDRLRVE--LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAAS---L 1313

Query: 134  TAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQ 193
             + +QD +E  +    Q++ +   IR+ +  +  L +   E EE    L+K V  L+   
Sbjct: 1314 ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL 1373

Query: 194  VE-----------YEGLKHEIKRFEEETVLLNSQLEDAI-------RLKEIAEHQLEEAL 235
             +            E L+   K+  ++   L+ +LE+         + K   + +L++  
Sbjct: 1374 ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLT 1433

Query: 236  ETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVK 295
              L ++R+  +NL K+  ++  L     SIS    ++AE+      + +         + 
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISA---RYAEERDRAEAEAREK---ETKALS 1487

Query: 296  LNGDYRTPTLRKGESLNPVSDLFSELN--ISEIQKLKQQLMQVEREKAILLANLQESQTQ 353
            L          K E       L +++   +S    + + + ++E+ K  L   ++E +TQ
Sbjct: 1488 LARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQ 1547

Query: 354  LEHTKGALTEQHERVHRLTEHVNAMRG-LQSSKELKAELDGEKGRDSGEEAHDYEVDING 412
            LE  +  L    +   RL  ++ AM+   +   + + E + EK R   ++  + E ++  
Sbjct: 1548 LEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELED 1607

Query: 413  LEILECKYRVAVTEV-----IDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVT 467
                E K R           IDLK +++A  E  NK+ +    +  K +++++ Y  ++ 
Sbjct: 1608 ----ERKQRALAVASKKKMEIDLK-DLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELE 1662

Query: 468  SLEKT-------TKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYH 520
                +       +KES +K+  +E E+ ++      +      A+ E    ++E+     
Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIT---- 1718

Query: 521  HVCLCNNETPNRVMLDYYR--QSRVTR-SGSLKGPDDPRGLLSPRLARRGVSSPVETRTS 577
                 N+ +    +LD  R  ++R+ +    L+       LL+ R  +    + ++  T 
Sbjct: 1719 -----NSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRK----TTLQVDTL 1769

Query: 578  SEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIK 637
            +  +A E + A K  +  +                L+  + ++    +  L   ++ + K
Sbjct: 1770 NAELAAERSAAQKSDNARQQ---------------LERQN-KELKAKLQELEGAVKSKFK 1813

Query: 638  HLQKAVDRSL--------QLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIA 689
                A++  +        Q +++RAAA +L    +K  + +  ++   +      +EQ+ 
Sbjct: 1814 ATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQME 1873

Query: 690  TLRAVLKANKQTAEVA-----LANL-KNKYENEKAMVTETMTKLRNELKALK 735
               A +K  K+  E A      AN  + K + E    TE    L  E+  LK
Sbjct: 1874 KANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLK 1925



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 92/499 (18%), Positives = 208/499 (41%), Gaps = 56/499 (11%)

Query: 2    AAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDS 61
            A EE L+  + ++ + ++L  ++ +    K    +    + + K  L+QQ +E+  + + 
Sbjct: 1491 ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEE 1550

Query: 62   LKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRA 121
            L+ EL+  ++A  +     + +    E   +T  +++  K+   + ++ E++ EL+  R 
Sbjct: 1551 LEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERK 1610

Query: 122  VVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENIT 181
                  A  +++     DLK+    +E       + I++ +  +A++     ELEE   +
Sbjct: 1611 QRALAVASKKKMEI---DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARAS 1667

Query: 182  LQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNE 241
              ++ +  K+++ + + L+ EI + +EE       L  + R +  AE + +E  + + N 
Sbjct: 1668 RDEIFAQSKESEKKLKSLEAEILQLQEE-------LASSERARRHAEQERDELADEITNS 1720

Query: 242  REQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYR 301
               K+          +L D    +     +  E+  E  ++ ++          LN  +R
Sbjct: 1721 ASGKS----------ALLDEKRRLEARIAQLEEELEEEQSNMEL----------LNDRFR 1760

Query: 302  TPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQ---------- 351
              TL+  ++LN  ++L +E   S  QK      Q+ER+   L A LQE +          
Sbjct: 1761 KTTLQV-DTLN--AELAAER--SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKAT 1815

Query: 352  -TQLEHTKGALTEQHERVHRLTEHVNAM--RGLQSSKELKAELDGEKGRDSGEEAHDYEV 408
             + LE   G L EQ E+  +     N +  R  +  KE+  +++ E+       A  Y+ 
Sbjct: 1816 ISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDER-----RHADQYKE 1870

Query: 409  DINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVT- 467
             +        + +  + E  +      A + K  + +++ T+       ++     ++  
Sbjct: 1871 QMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRR 1930

Query: 468  --SLEKTTKESGEKMAHME 484
               +  ++  SG +  H+E
Sbjct: 1931 GGPISFSSSRSGRRQLHLE 1949



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 85/415 (20%), Positives = 166/415 (40%), Gaps = 71/415 (17%)

Query: 413  LEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKT 472
            LE +E K++  + E   L  +++A  E + ++ E     +A+  +K Q  +E +  LE  
Sbjct: 875  LEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM----RARLAAKKQELEEILHDLESR 930

Query: 473  TKESGEKMAHMEKELQKMTSIA-------NENHSTLNTAQDELVTFSEELAQLYHHVCLC 525
             +E  E+   ++ E +KM +         +E        Q E VT   ++ ++   + L 
Sbjct: 931  VEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLL 990

Query: 526  NNETPNRVMLDYYRQSRVTRSGSLKGPDDPRG--LLSPRLARRGVSSPVETRTSSEPVAK 583
             ++    +      + R+    S    ++ +   L   R  +  + S +E R   E   +
Sbjct: 991  EDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR 1050

Query: 584  ESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAV 643
            +  E +K     +T  +                                +DQI  LQ  +
Sbjct: 1051 QELEKAKRKLDGETTDL--------------------------------QDQIAELQAQI 1078

Query: 644  DR-SLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTA 702
            D   LQL+++     EL   + +  +  + +   LK ++   + QIA L+   ++ K + 
Sbjct: 1079 DELKLQLAKKE---EELQGALARGDDETLHKNNALK-VVRELQAQIAELQEDFESEKAS- 1133

Query: 703  EVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEM 762
                   +NK E +K  ++E +  L+ EL+   +  A    LR    T+ ++ V +L + 
Sbjct: 1134 -------RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR----TKREQEVAELKK- 1181

Query: 763  QRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIG 817
                 A E+E K     ++   Q+       LE+L    EQ++R K  L K+K G
Sbjct: 1182 -----ALEEETKNHEAQIQDMRQRHATA---LEELSEQLEQAKRFKANLEKNKQG 1228


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
            sapiens]
          Length = 1843

 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 191/961 (19%), Positives = 380/961 (39%), Gaps = 166/961 (17%)

Query: 5    EVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ 64
            EV +       ++E   + LT+T  E     +       + L ++++   L  + + L+ 
Sbjct: 453  EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512

Query: 65   ELEQLKEAFGQSFSIHRKVAEDGETREETL--LQESASKEAYYLGKILEMQNE------- 115
            E+ Q K++     ++ + + ++    E+T+  L+E++ ++     KILE +NE       
Sbjct: 513  EIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQI----KILEQENEHLNQTVS 568

Query: 116  -LKQ-----SRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREAR-- 167
             L+Q     + A V +++ EN+ L   +++       +E ++ ++K E+  YK +  R  
Sbjct: 569  SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE 628

Query: 168  -LLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEI 226
             L  +   LE+EN  LQK ++ LK    + E L+ E           NS+LE   R    
Sbjct: 629  ELENELHHLEKENELLQKKITNLKITCEKIEALEQE-----------NSELERENR---- 673

Query: 227  AEHQLEEALETLKNEREQKNNLRKELSQY----ISLNDNHISISVDGLKFAEDGSEPNND 282
               +L++ L++ KN   Q  +L KE SQ     + L  N  S+    +K A+   E    
Sbjct: 674  ---KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKEL 730

Query: 283  DKMNGHIHGPLVKLNG---------------DYRTPTLRK--GESLNPVSDLFSEL---- 321
            +     +   L  L                 D     L+K    S   +  L SEL    
Sbjct: 731  ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790

Query: 322  --------NISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTE 373
                    N+ E++   ++L Q+E+E      +L++  +QLE  K  L ++++R+ +  E
Sbjct: 791  MENQTLQKNLEELKISSKRLEQLEKEN----KSLEQETSQLEKDKKQLEKENKRLRQQAE 846

Query: 374  HVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTE-VIDLKA 432
              +    L+ +      L+ E  +   +E   Y+     L+ LE + +  V    ID+K 
Sbjct: 847  IKDTT--LEENNVKIGNLEKE-NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT 903

Query: 433  EI----KALKEKYNKSVENYTDEKAKYE-SKIQMYDEQVTSLEKTTKESGEKM--AHMEK 485
             +      + EK      N   EK  +E  KI +  E++   E++T +S  K+  + +E 
Sbjct: 904  LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLES 963

Query: 486  ELQKMTSIANENHSTLNTAQDELVTFSEELAQ-----LYHHVCLCNNETPNRVMLD---- 536
             L+K   I  E  + L    +E   ++++L Q       ++  L   +   R++      
Sbjct: 964  TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1023

Query: 537  ------YYRQSRVTRSGSLKGPD-------DPRGLLSPRLARRGVSSPVETRTSS----- 578
                  + R+S+ T    LK  D       +   L + + A +     +ET+ ++     
Sbjct: 1024 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1083

Query: 579  -----EPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAII- 632
                 + V+ +    + +    K    +  + +  +S +   + +  +  ++ N N  + 
Sbjct: 1084 LALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1143

Query: 633  --RDQIKHLQKAV---DRSLQLSRQRAAARELAPMIDK----------------DKEALM 671
              R+ +K L  ++      L+L  +R A+ E   +I K                D E   
Sbjct: 1144 KEREDLKSLYDSLIKDHEKLELLHERQAS-EYESLISKHGTLKSAHKNLEVEHRDLEDRY 1202

Query: 672  EEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNEL 731
             ++LK K  L    + +   +  +    +  E   A  K K   E   +  T ++L  E 
Sbjct: 1203 NQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYK-KLCGENDRLNHTYSQLLKET 1261

Query: 732  KALKEDAATFSSL---RAMFATRCDEYVTQLDEMQRQLAAA------------------- 769
            + L+ D     SL     +  TR +   ++L E  +QL                      
Sbjct: 1262 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE 1321

Query: 770  EDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKIVSSLLPPY 829
            E+ +  L+ +  + +Q +  L Q +E  +  H + R+   KL + +    K+   ++  Y
Sbjct: 1322 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY 1381

Query: 830  R 830
            +
Sbjct: 1382 K 1382



 Score = 86.7 bits (213), Expect = 8e-17
 Identities = 185/895 (20%), Positives = 347/895 (38%), Gaps = 177/895 (19%)

Query: 14   KTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ--------- 64
            K +I RL +EL E T              E+ L  KQ+ +++E E   L+Q         
Sbjct: 257  KAKIRRLRQELEEKT--------------EQLLDCKQELEQMEIELKRLQQENMNLLSDA 302

Query: 65   --------ELEQLKEAFGQSFSIHRKVA--------------------EDGET--REETL 94
                    EL+ L+E   +   +  +V+                    ED +     +T+
Sbjct: 303  RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM 362

Query: 95   LQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENN---EMV---- 147
            L++          K+ E++ E  Q +A + +++ E +     +++L E N   EM     
Sbjct: 363  LEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQS 422

Query: 148  ---------ELQRIRMKDEIRE----------YKFREARLLQDYTELEEENITLQKLVST 188
                     EL++I    E+ E           +   +RLL    +LE EN +L K V  
Sbjct: 423  MDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLL----KLEMENQSLTKTVEE 478

Query: 189  LKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNL 248
            L+      EG   +I + E+E   L+ ++       EI E+++ +  ++L+N +    +L
Sbjct: 479  LRTTVDSVEGNASKILKMEKENQRLSKKV-------EILENEIVQEKQSLQNCQNLSKDL 531

Query: 249  RKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRK- 307
             KE +Q     +     S   +K  E  +E  N    +        +++ + R   + K 
Sbjct: 532  MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS---QISAEARVKDIEKE 588

Query: 308  ----GESLNPVSDLFSELNISEIQ----------------KLKQQLMQVEREKAIL---L 344
                 ES+   S   S++   + Q                +L+ +L  +E+E  +L   +
Sbjct: 589  NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648

Query: 345  ANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAH 404
             NL+ +  ++E    AL +++  + R  E+    + L S K L  +L+  +  +S  +  
Sbjct: 649  TNLKITCEKIE----ALEQENSELER--ENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702

Query: 405  DYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYT---DEKAKYESKIQM 461
            + E+  N +E L+C         ++ K E+++ KE+  K +E       +  + E   Q 
Sbjct: 703  NLELRRN-VESLKCASMKMAQLQLENK-ELESEKEQLKKGLELLKASFKKTERLEVSYQG 760

Query: 462  YDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHH 521
             D +   L+KT + S +K+  +E ELQ +       + TL    +EL   S+ L QL   
Sbjct: 761  LDIENQRLQKTLENSNKKIQQLESELQDL----EMENQTLQKNLEELKISSKRLEQLEKE 816

Query: 522  VCLCNNET----PNRVMLD----YYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVE 573
                  ET     ++  L+      RQ    +  +L+  +   G L      + +S  + 
Sbjct: 817  NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE--NKTLSKEIG 874

Query: 574  TRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIR 633
                S    KE  + +KE     T  I  ++T           D+  E +    +N  + 
Sbjct: 875  IYKESCVRLKELEKENKELVKRATIDIKTLVTL--------REDLVSEKLKTQQMNNDLE 926

Query: 634  DQIKHLQKA---------VDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTK 684
                 L+K           ++S   SR +    +L   + K  E   E+I  L++ L   
Sbjct: 927  KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 986

Query: 685  REQIATLRAVLKANKQTAEV---------------ALANLKNKYENEKAMVTETMTKLRN 729
                  LR  LK  K+  E                 ++   NK+E E    T  + K+++
Sbjct: 987  TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKD 1046

Query: 730  ELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTL---NTLLR 781
             L  ++ + AT  + +    T+  +  TQ + +Q Q+ A + +  +L   NT L+
Sbjct: 1047 RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ 1101



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 135/559 (24%), Positives = 238/559 (42%), Gaps = 74/559 (13%)

Query: 3    AEEVLQTVDHYKTEIERLTKELT--ETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYD 60
            AEE+   + H + E E L K++T  + T EKI+A             L+Q+  ELE E  
Sbjct: 627  AEELENELHHLEKENELLQKKITNLKITCEKIEA-------------LEQENSELERENR 673

Query: 61   SLKQELEQLKEAFGQSFSIHRKVAEDGETREETL-LQESASKEAYYLGKILEMQNELKQS 119
             LK+ L+  K    Q  S+ +   E+ +  EE L L+ +         K+ ++Q E K+ 
Sbjct: 674  KLKKTLDSFKNLTFQLESLEK---ENSQLDEENLELRRNVESLKCASMKMAQLQLENKEL 730

Query: 120  RAVVTNVQAENERLTAV---VQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELE 176
             +    ++   E L A     + L+ + + ++++  R++  +     +  +L  +  +LE
Sbjct: 731  ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790

Query: 177  EENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLL---NSQLE-DAIRLK---EIAEH 229
             EN TLQK +  LK +    E L+ E K  E+ET  L     QLE +  RL+   EI + 
Sbjct: 791  MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850

Query: 230  QLEEALETLKNEREQKNNLRKELSQY----ISLND---------NHISISVDGLKFAEDG 276
             LEE    + N  ++   L KE+  Y    + L +            +I +  L    + 
Sbjct: 851  TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED 910

Query: 277  --SEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLN---PVSDLFSELNISEIQKLKQ 331
              SE     +MN      L KL  +     L K   L+      D   +L  S+++   +
Sbjct: 911  LVSEKLKTQQMN----NDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLK 966

Query: 332  QLMQVEREK-AILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAE 390
            + ++++ EK A L A L+ES    +  +  L    +    L +  +  R +QSS  +  E
Sbjct: 967  KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1026

Query: 391  LDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTD 450
             D +  R+S E            E+L+ K R  + EV    A ++A K+     ++    
Sbjct: 1027 -DNKWERESQETTR---------ELLKVKDR--LIEVERNNATLQAEKQALKTQLKQLET 1074

Query: 451  EKAKYESKIQMYDEQVTSLEK--TTKESGEKMAHMEKEL--QKMTSIANEN------HST 500
            +    +++I     Q  SL++  TT ++      +E      + TS+ N+N       S+
Sbjct: 1075 QNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS 1134

Query: 501  LNTAQDELVTFSEELAQLY 519
            L    + ++   E+L  LY
Sbjct: 1135 LENENESVIKEREDLKSLY 1153



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 58/268 (21%), Positives = 112/268 (41%), Gaps = 33/268 (12%)

Query: 4    EEVLQTVDHYKTEIERLTK--ELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDS 61
            E V++  +  K+  + L K  E  E  HE+ QA+EY  ++ +   TLK  +  LE E+  
Sbjct: 1140 ESVIKEREDLKSLYDSLIKDHEKLELLHER-QASEYESLISKHG-TLKSAHKNLEVEHRD 1197

Query: 62   LKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRA 121
            L+    QL +  GQ   + + +    +  +E +L E+ + E                  A
Sbjct: 1198 LEDRYNQLLKQKGQLEDLEKML----KVEQEKMLLENKNHETV---------------AA 1238

Query: 122  VVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENIT 181
                +  EN+RL      L +  E+++     +K  +   K  + RL  ++++L+E+   
Sbjct: 1239 EYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQ 1298

Query: 182  LQKLVSTLKQNQVEY---------EGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLE 232
            L  + ST   NQ E          E  +H + + +   +   + LE  +  K++   +  
Sbjct: 1299 LD-ITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQR 1357

Query: 233  EALETLKNEREQKNNLRKELSQYISLND 260
            + ++ L   R QK  L +++       D
Sbjct: 1358 QYIDKLNELRRQKEKLEEKIMDQYKFYD 1385


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
            sapiens]
          Length = 1870

 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 198/959 (20%), Positives = 378/959 (39%), Gaps = 163/959 (16%)

Query: 5    EVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ 64
            EV +       ++E   + LT+T  E     +       + L ++++   L  + + L+ 
Sbjct: 453  EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512

Query: 65   ELEQLKEAFGQSFSIHRKVAEDGETREETL--LQESASKEAYYLGKILEMQNE------- 115
            E+ Q K++     ++ + + ++    E+T+  L+E++ ++     KILE +NE       
Sbjct: 513  EIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQI----KILEQENEHLNQTVS 568

Query: 116  -LKQ-----SRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREAR-- 167
             L+Q     + A V +++ EN+ L   +++       +E ++ ++K E+  YK +  R  
Sbjct: 569  SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE 628

Query: 168  -LLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEI 226
             L  +   LE+EN  LQK ++ LK    + E L+ E           NS+LE   R    
Sbjct: 629  ELENELHHLEKENELLQKKITNLKITCEKIEALEQE-----------NSELERENR---- 673

Query: 227  AEHQLEEALETLKNEREQKNNLRKELSQY----ISLNDNHISISVDGLKFAEDGSEPNND 282
               +L++ L++ KN   Q  +L KE SQ     + L  N  S+    +K A+   E    
Sbjct: 674  ---KLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKEL 730

Query: 283  DKMNGHIHGPLVKLNG---------------DYRTPTLRK--GESLNPVSDLFSEL---- 321
            +     +   L  L                 D     L+K    S   +  L SEL    
Sbjct: 731  ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790

Query: 322  --------NISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTE 373
                    N+ E++   ++L Q+E+E      +L++  +QLE  K  L ++++R+ +  E
Sbjct: 791  MENQTLQKNLEELKISSKRLEQLEKEN----KSLEQETSQLEKDKKQLEKENKRLRQQAE 846

Query: 374  HVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTE-VIDLKA 432
              +    L+ +      L+ E  +   +E   Y+     L+ LE + +  V    ID+K 
Sbjct: 847  IKDTT--LEENNVKIGNLEKE-NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT 903

Query: 433  EI---------KALKEKYNKSVENYTD--EKAKYESKIQMYDEQVT---------SLEKT 472
             +         K   ++ N  +E  T   EK     +  ++DEQ T          LE T
Sbjct: 904  LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLEST 963

Query: 473  TKES----GEKMAHMEKELQKMTS----------IANENHSTLNTAQDE--LVTFSEELA 516
             K+S     EK+A +E  L++ T+             +N+  L   QDE  +V  S  ++
Sbjct: 964  LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPIS 1023

Query: 517  QLYHHVCLCNNETP---------------NRVMLDYYRQSRVTRSGSLKGPDDPRGLLSP 561
               +     + ET                N   L   +Q+  T+   L+  ++       
Sbjct: 1024 GEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1083

Query: 562  RLARRGVSSPVETRTSSEPVAKESTEASK-EPSPTKTPTISPVITAPPSSPVLDTSDIRK 620
             L R+ VS   +  T     AK   E S      T     +  +    SS   +   + K
Sbjct: 1084 ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK 1143

Query: 621  EPMNIYNL-NAIIRD----QIKHLQKAVDRSLQLSRQRA--AARELAPMIDKDKEALMEE 673
            E  ++ +L +++I+D    ++ H ++A +    +S+     +A +   +  +D E    +
Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203

Query: 674  ILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKA 733
            +LK K  L    + +   +  +    +  E   A  K K   E   +  T ++L  E + 
Sbjct: 1204 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYK-KLCGENDRLNHTYSQLLKETEV 1262

Query: 734  LKEDAATFSSL---RAMFATRCDEYVTQLDEMQRQLAAA-------------------ED 771
            L+ D     SL     +  TR +   ++L E  +QL                      E+
Sbjct: 1263 LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE 1322

Query: 772  EKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKIVSSLLPPYR 830
             +  L+ +  + +Q +  L Q +E  +  H + R+   KL + +    K+   ++  Y+
Sbjct: 1323 NRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYK 1381



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 185/892 (20%), Positives = 352/892 (39%), Gaps = 172/892 (19%)

Query: 14   KTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ--------- 64
            K +I RL +EL E T              E+ L  KQ+ +++E E   L+Q         
Sbjct: 257  KAKIRRLRQELEEKT--------------EQLLDCKQELEQMEIELKRLQQENMNLLSDA 302

Query: 65   --------ELEQLKEAFGQSFSIHRKVA--------------------EDGET--REETL 94
                    EL+ L+E   +   +  +V+                    ED +     +T+
Sbjct: 303  RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM 362

Query: 95   LQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENN---EMV---- 147
            L++          K+ E++ E  Q +A + +++ E +     +++L E N   EM     
Sbjct: 363  LEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQS 422

Query: 148  ---------ELQRIRMKDEIRE----------YKFREARLLQDYTELEEENITLQKLVST 188
                     EL++I    E+ E           +   +RLL    +LE EN +L K V  
Sbjct: 423  MDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLL----KLEMENQSLTKTVEE 478

Query: 189  LKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNL 248
            L+      EG   +I + E+E   L+ ++       EI E+++ +  ++L+N +    +L
Sbjct: 479  LRTTVDSVEGNASKILKMEKENQRLSKKV-------EILENEIVQEKQSLQNCQNLSKDL 531

Query: 249  RKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRK- 307
             KE +Q     +     S   +K  E  +E  N    +        +++ + R   + K 
Sbjct: 532  MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS---QISAEARVKDIEKE 588

Query: 308  ----GESLNPVSDLFSELNISEIQ----------------KLKQQLMQVEREKAIL---L 344
                 ES+   S   S++   + Q                +L+ +L  +E+E  +L   +
Sbjct: 589  NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648

Query: 345  ANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAH 404
             NL+ +  ++E    AL +++  + R  E+    + L S K L  +L+  +  +S  +  
Sbjct: 649  TNLKITCEKIE----ALEQENSELER--ENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702

Query: 405  DYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYT---DEKAKYESKIQM 461
            + E+  N +E L+C         ++ K E+++ KE+  K +E       +  + E   Q 
Sbjct: 703  NLELRRN-VESLKCASMKMAQLQLENK-ELESEKEQLKKGLELLKASFKKTERLEVSYQG 760

Query: 462  YDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHH 521
             D +   L+KT + S +K+  +E ELQ +       + TL    +EL   S+ L QL   
Sbjct: 761  LDIENQRLQKTLENSNKKIQQLESELQDL----EMENQTLQKNLEELKISSKRLEQLEKE 816

Query: 522  VCLCNNET----PNRVMLD----YYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVE 573
                  ET     ++  L+      RQ    +  +L+  +   G L      + +S  + 
Sbjct: 817  NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE--NKTLSKEIG 874

Query: 574  TRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPS--SPVLDT----SDIRKEPMNIYN 627
                S    KE  + +KE     T  I  ++T      S  L T    +D+ K    +  
Sbjct: 875  IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934

Query: 628  LNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQ 687
            +  + ++++ H +++ D      R +    +L   + K  E   E+I  L++ L      
Sbjct: 935  I-GLNKERLLHDEQSTD-----DRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 988

Query: 688  IATLRAVLKANKQTAEV---------------ALANLKNKYENEKAMVTETMTKLRNELK 732
               LR  LK  K+  E                 ++   NK+E E    T  + K+++ L 
Sbjct: 989  NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048

Query: 733  ALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTL---NTLLR 781
             ++ + AT  + +    T+  +  TQ + +Q Q+ A + +  +L   NT L+
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ 1100



 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 136/558 (24%), Positives = 232/558 (41%), Gaps = 73/558 (13%)

Query: 3    AEEVLQTVDHYKTEIERLTKELT--ETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYD 60
            AEE+   + H + E E L K++T  + T EKI+A             L+Q+  ELE E  
Sbjct: 627  AEELENELHHLEKENELLQKKITNLKITCEKIEA-------------LEQENSELERENR 673

Query: 61   SLKQELEQLKEAFGQSFSIHRKVAEDGETREETL-LQESASKEAYYLGKILEMQNELKQS 119
             LK+ L+  K    Q  S+ +   E+ +  EE L L+ +         K+ ++Q E K+ 
Sbjct: 674  KLKKTLDSFKNLTFQLESLEK---ENSQLDEENLELRRNVESLKCASMKMAQLQLENKEL 730

Query: 120  RAVVTNVQAENERLTAV---VQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELE 176
             +    ++   E L A     + L+ + + ++++  R++  +     +  +L  +  +LE
Sbjct: 731  ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790

Query: 177  EENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLL---NSQLE-DAIRLK---EIAEH 229
             EN TLQK +  LK +    E L+ E K  E+ET  L     QLE +  RL+   EI + 
Sbjct: 791  MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850

Query: 230  QLEEALETLKNEREQKNNLRKELSQY----ISLND---------NHISISVDGLKFAEDG 276
             LEE    + N  ++   L KE+  Y    + L +            +I +  L    + 
Sbjct: 851  TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED 910

Query: 277  --SEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLN---PVSDLFSELNISEIQKLKQ 331
              SE     +MN      L KL  +     L K   L+      D +  L       LK+
Sbjct: 911  LVSEKLKTQQMN----NDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKK 966

Query: 332  QLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAEL 391
             L   E + A L A L+ES    +  +  L    +    L +  +  R +QSS  +  E 
Sbjct: 967  SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE- 1025

Query: 392  DGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDE 451
            D +  R+S E            E+L+ K R  + EV    A ++A K+     ++    +
Sbjct: 1026 DNKWERESQETTR---------ELLKVKDR--LIEVERNNATLQAEKQALKTQLKQLETQ 1074

Query: 452  KAKYESKIQMYDEQVTSLEK--TTKESGEKMAHMEKEL--QKMTSIANEN------HSTL 501
                +++I     Q  SL++  TT ++      +E      + TS+ N+N       S+L
Sbjct: 1075 NNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSL 1134

Query: 502  NTAQDELVTFSEELAQLY 519
                + ++   E+L  LY
Sbjct: 1135 ENENESVIKEREDLKSLY 1152



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 58/268 (21%), Positives = 112/268 (41%), Gaps = 33/268 (12%)

Query: 4    EEVLQTVDHYKTEIERLTK--ELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDS 61
            E V++  +  K+  + L K  E  E  HE+ QA+EY  ++ +   TLK  +  LE E+  
Sbjct: 1139 ESVIKEREDLKSLYDSLIKDHEKLELLHER-QASEYESLISKHG-TLKSAHKNLEVEHRD 1196

Query: 62   LKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRA 121
            L+    QL +  GQ   + + +    +  +E +L E+ + E                  A
Sbjct: 1197 LEDRYNQLLKQKGQLEDLEKML----KVEQEKMLLENKNHETV---------------AA 1237

Query: 122  VVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENIT 181
                +  EN+RL      L +  E+++     +K  +   K  + RL  ++++L+E+   
Sbjct: 1238 EYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQ 1297

Query: 182  LQKLVSTLKQNQVEY---------EGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLE 232
            L  + ST   NQ E          E  +H + + +   +   + LE  +  K++   +  
Sbjct: 1298 LD-ITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQR 1356

Query: 233  EALETLKNEREQKNNLRKELSQYISLND 260
            + ++ L   R QK  L +++       D
Sbjct: 1357 QYIDKLNELRRQKEKLEEKIMDQYKFYD 1384


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 154/843 (18%), Positives = 339/843 (40%), Gaps = 130/843 (15%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEK-LTLKQQYDELEAEYDSL 62
            E+V Q  +  K + E   K+  E  H+++Q  +  L   +++ L+L+   +EL ++ +  
Sbjct: 575  EQVTQLTEKLKNQSES-HKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633

Query: 63   KQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYL---GKILEMQNELKQS 119
            K+++ QL                  + + E LL   A+K A        +   QN L+  
Sbjct: 634  KEKVSQLDIQI--------------KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK 679

Query: 120  RAVVTNVQAENERLTAVVQD---------------------LKENNEMVELQRIRMKDEI 158
            +  +  +  + +++TA +QD                     L++  E +E Q  +++ + 
Sbjct: 680  QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADS 739

Query: 159  REYKFREARLLQDYTELEEENITLQKLVSTL-KQNQVE-----------------YEGLK 200
             E K  + + LQD  +  + N  L+   + L KQ ++E                  E +K
Sbjct: 740  LEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIK 799

Query: 201  HEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLND 260
             ++ + EEE  +L    E   +  +I   +L   ++T   E ++    ++ L   +S   
Sbjct: 800  QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK 859

Query: 261  NHISISVDGLKFAEDGSEPNNDDKMNGHI----------HGPLVKLNGDYRTPTLRKGES 310
            + +S   D LK ++   E  N       +          H   V++    +     K +S
Sbjct: 860  DKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK-KS 918

Query: 311  LNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHR 370
            L    +   +L + E+  +++QL+Q +         L++++ + +  +G + E  +   +
Sbjct: 919  LEKEKEASHQLKL-ELNSMQEQLIQAQN-------TLKQNEKEEQQLQGNINELKQSSEQ 970

Query: 371  LTEHVNAMRG-LQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVA------ 423
              + + A++G L+ +   K EL+ +  +   + A +   +   + +L+  Y  +      
Sbjct: 971  KKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030

Query: 424  --------VTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKE 475
                     +E++  + ++K+++EK + + E+    + +  ++ ++  E  T+     ++
Sbjct: 1031 LQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQD 1090

Query: 476  SGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNE-TPNRVM 534
            S +K    E++LQ+      +     +  + ELV    +LA++    C    E T     
Sbjct: 1091 SAKK----EQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEE 1146

Query: 535  LDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRG----VSSPVETRTSSEPVAKESTEASK 590
            L  ++   +    +LK  D  + L+  +L  +G    + + VE    ++ + K+  +  +
Sbjct: 1147 LKSHKLESIKEITNLK--DAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEE 1204

Query: 591  EPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLS 650
            E                     L    I KE      L++ I+++   ++K  +   +L+
Sbjct: 1205 EE--------------------LKKEFIEKEA----KLHSEIKEKEVGMKKHEENEAKLT 1240

Query: 651  RQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALAN-L 709
             Q  A  E    + K+ ++    + +L+      R +IA L A ++ N+      L   L
Sbjct: 1241 MQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCL 1300

Query: 710  KNKYENEK--AMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLA 767
            K + E EK    V E   KL N   A++E      SL+       +    + +E+Q  +A
Sbjct: 1301 KGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMA 1360

Query: 768  AAE 770
              +
Sbjct: 1361 CGK 1363



 Score = 86.7 bits (213), Expect = 8e-17
 Identities = 176/873 (20%), Positives = 367/873 (42%), Gaps = 121/873 (13%)

Query: 14   KTEIERLTKELTETTHEKIQA----AEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQL 69
            ++EI +L  +L ET  +  +A     E   +  E+ +  +QQ  +L+ +   L+   EQL
Sbjct: 413  QSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLE---EQL 469

Query: 70   KEAFGQSFSIHRKVAEDGET-REETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQA 128
            KE    S  +  ++ +  +  +E+  LQ+S +       K+ E QN+L+Q    + +   
Sbjct: 470  KEKVTNSTELQHQLDKTKQQHQEQQALQQSTT------AKLREAQNDLEQVLRQIGDKDQ 523

Query: 129  ENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVST 188
            + + L A++Q  KEN  ++E +R  +  +I+  +   A L     +L+E+N TLQ+ V+ 
Sbjct: 524  KIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL----NQLQEKNHTLQEQVTQ 579

Query: 189  LKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNL 248
            L       E LK++ +  ++    L+ Q+++       A+ ++  +LET  NE   + N 
Sbjct: 580  LT------EKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV-LSLETSVNELNSQLNE 632

Query: 249  RKELSQYISLN---DNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNG-----DY 300
             KE    + +       + +S +  K A+     N+ D     +     +LN      D 
Sbjct: 633  SKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQ 692

Query: 301  RTPTLR-KGESLNPVSDLFSE-----LNISE-IQKLKQQLMQVEREKAILLANLQESQTQ 353
             T  L+ K E  + +     E     L++ +  ++L+ Q+ ++E +   + A+ +++   
Sbjct: 693  VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD 752

Query: 354  LEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGE-------KGRDSGEEAHDY 406
            L+  +   T+   R   L++ +   + + SS  L  +   E       K     EE    
Sbjct: 753  LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQIL 812

Query: 407  EVDINGL--------EILECKYRVAVTEVIDLKAEIKAL-------KEKYNKSVENYTDE 451
            + D   L        E L  + +  VTE+  +K E +AL       K+K +K  ++  + 
Sbjct: 813  KQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872

Query: 452  KAKYESKIQMYDEQVTSLEKTTKE-----------SGEKMAHMEKELQKMTSIANENHST 500
            K+++E + Q     +  LEKT KE           + ++   ++K L+K    +++    
Sbjct: 873  KSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE 932

Query: 501  LNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLS 560
            LN+ Q++L+     L Q         NE   + +     + + +     K  +  +G L 
Sbjct: 933  LNSMQEQLIQAQNTLKQ---------NEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983

Query: 561  PRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRK 620
              + ++   + +E +     + ++ T+A++E +  K       I+   ++        ++
Sbjct: 984  IAVLQK---TELENK-----LQQQLTQAAQELAAEKEK-----ISVLQNNYEKSQETFKQ 1030

Query: 621  EPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSL 680
               + Y   + +    + L K+V+  L L+++   +         ++  L++E+   K+ 
Sbjct: 1031 LQSDFYGRESELLATRQDL-KSVEEKLSLAQEDLISNRNQ---IGNQNKLIQELKTAKAT 1086

Query: 681  L---STKREQIATLRAV----LKANKQTAEVALANLKNK---YENEKAMVTETMTKLRNE 730
            L   S K+EQ    R      ++  K   E  L N K+K    E  K    + +TKL  E
Sbjct: 1087 LEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEE 1146

Query: 731  LKA-----------LKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDE-KKTLNT 778
            LK+           LK+        +     + D     +++ +R     +D+ KK    
Sbjct: 1147 LKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEE 1206

Query: 779  LLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKL 811
            L +  I+++  L   +++ E   ++   ++ KL
Sbjct: 1207 LKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKL 1239



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 172/874 (19%), Positives = 348/874 (39%), Gaps = 116/874 (13%)

Query: 19   RLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQL------KEA 72
            RL+   T      ++ +E G    E    LK++  E+E +Y  LK E +QL      KE 
Sbjct: 352  RLSASETSLHRIHVELSEKG----EATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ 407

Query: 73   FGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQ----NELKQSRAVVTNVQA 128
             G         +E  +   + L  E    EA+  G++ E +     +L      V ++Q 
Sbjct: 408  HGLQLQ-----SEINQLHSKLLETERQLGEAH--GRLKEQRQLSSEKLMDKEQQVADLQL 460

Query: 129  ENERLTAVVQDLKENNEMVELQRIRMKDEIREY---------KFREA-----RLLQDYTE 174
            +  RL   +++   N+  ++ Q  + K + +E          K REA     ++L+   +
Sbjct: 461  KLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520

Query: 175  LEEENITLQKLVSTLKQN----QVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQ 230
             +++   L+ L+   K+N    + E E L  +I+  E ET +LN   E    L+E    Q
Sbjct: 521  KDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQE----Q 576

Query: 231  LEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIH 290
            + +  E LKN+ E     ++ L   +     H+  + D +   E      N         
Sbjct: 577  VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK 636

Query: 291  GPLVKLNGDYRTPTLRKGESLNPV--SDLFSELNISE--IQKLKQQLMQVEREKAILLAN 346
               + +    +T  L   E+      +DL + L+ ++  +Q  +Q+L ++  +   + A 
Sbjct: 637  VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK 696

Query: 347  LQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDY 406
            LQ+ Q      +  L E  E+   L +    + G    +  K E D  + + S E+A   
Sbjct: 697  LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG----QIKKLEADSLEVKASKEQALQ- 751

Query: 407  EVDINGLEILECKYRVAVTEV---IDLKAEIKALK----EKYNKSVENYTDEKAKYESKI 459
              D+     L     +  TE+   ++++ EI +      +K ++++E+   +  K E + 
Sbjct: 752  --DLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809

Query: 460  QMYDEQVTSLEKTTK----ESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEEL 515
            Q+  +   +L + TK    E   ++     ELQK+        + L+T +D+L   S+ L
Sbjct: 810  QILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSL 869

Query: 516  AQLYHHVCLCNNETPNRVMLDYYR-------QSRVTRSGSLKGPDD-PRGLLSPRLARRG 567
                       N+     +LD  +       Q +V    +LK   +  + L   + A   
Sbjct: 870  KNSKSEF-EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQ 928

Query: 568  VSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIY- 626
            +   + +       A+ + + +++        I         + +  +S+ +K+ +    
Sbjct: 929  LKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNI---------NELKQSSEQKKKQIEALQ 979

Query: 627  -NLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKR 685
              L   +  + +   K   +  Q +++ AA +E   ++  + E   E   +L+S    + 
Sbjct: 980  GELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039

Query: 686  EQIATLRAVLKANKQTAEVALANL---KNKYENEKAMVTETMT--------------KLR 728
             ++   R  LK+ ++   +A  +L   +N+  N+  ++ E  T              +L+
Sbjct: 1040 SELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQ 1099

Query: 729  NELKAL-----------KEDAATFSSLRAMFATRC--DEYVTQL-DEMQRQLAAAEDEKK 774
               KAL           KE     S L  +   +C  ++ +T+L +E++     +  E  
Sbjct: 1100 ERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEIT 1159

Query: 775  TLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSK 808
             L    ++ IQQKL L  + + L+   EQ +R++
Sbjct: 1160 NLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQ 1193



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 148/725 (20%), Positives = 292/725 (40%), Gaps = 111/725 (15%)

Query: 95  LQESASKEAYY---LGKILEMQNELKQSRA----VVTNVQAENERLTAVVQD-------L 140
           LQ S  +E +Y   L K LE    L+Q  A    +VT+  AE + L   +++       +
Sbjct: 95  LQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNI 154

Query: 141 KENNEMVELQRIRMKDEIREYK--FREARLLQDYTELEEENITLQKLVSTLKQNQVEYEG 198
           K+  ++ E +  ++  EI + K  + E R L+   E  E+ +T  +L   L +     + 
Sbjct: 155 KQMKDLFEQKAAQLATEIADIKSKYDEERSLR---EAAEQKVT--RLTEELNKEATVIQD 209

Query: 199 LKHEIKRFEEETVLLNSQLED-AIRLKEIAEHQLEEALETLKNEREQ---KNNLRKELSQ 254
           LK E+        L    +ED A+  KE+ + Q      TL+ ERE    K+  +K  SQ
Sbjct: 210 LKTEL--------LQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ 261

Query: 255 YISLNDNHISISVDGLKFAEDGSEPNND-DKMNGHIHGPLVKLNGDYRTPTLRKGESLNP 313
           Y S       +  +  K  ++ +    +  K+   ++  L + N       L+K +    
Sbjct: 262 YASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVN-ELTQKNQTLTENLLKKEQDYTK 320

Query: 314 VSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTE 373
           + +  +E ++S+ + ++  L Q + +   L + L  S+T L      L+E+ E   +L E
Sbjct: 321 LEEKHNEESVSK-KNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKE 379

Query: 374 HVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAE 433
            ++ +      + LKAE    + +   +E H  ++     EI +   ++  TE   L   
Sbjct: 380 ELSEVE--TKYQHLKAEFKQLQQQREEKEQHGLQLQS---EINQLHSKLLETER-QLGEA 433

Query: 434 IKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSI 493
              LKE+   S E   D+    E ++     +++ LE+  KE       ++ +L K    
Sbjct: 434 HGRLKEQRQLSSEKLMDK----EQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ 489

Query: 494 ANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPD 553
             E  +   +   +L     +L Q+   +   + +  N   L             L+   
Sbjct: 490 HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEAL-------------LQKSK 536

Query: 554 DPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVL 613
           +   LL     R  + + ++       V  +  E        K  T+   +T   +  + 
Sbjct: 537 ENISLLEKE--REDLYAKIQAGEGETAVLNQLQE--------KNHTLQEQVTQL-TEKLK 585

Query: 614 DTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEE 673
           + S+  K+     NL+  +++Q  HL+ A DR L L     +  EL   +++ KE + + 
Sbjct: 586 NQSESHKQAQE--NLHDQVQEQKAHLRAAQDRVLSLE---TSVNELNSQLNESKEKVSQL 640

Query: 674 ILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKA 733
            +++K+    K E + +  A   A +       A+L+N  +  +  + +   +L      
Sbjct: 641 DIQIKA----KTELLLSAEAAKTAQR-------ADLQNHLDTAQNALQDKQQEL------ 683

Query: 734 LKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQR 793
                              ++  TQLD++  +L   ++    L + L+   ++ L+L Q+
Sbjct: 684 -------------------NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQK 724

Query: 794 LEDLE 798
            E+LE
Sbjct: 725 TEELE 729


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 91.3 bits (225), Expect = 3e-18
 Identities = 173/814 (21%), Positives = 336/814 (41%), Gaps = 102/814 (12%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLK 63
            E+ L+ +D  +TE+E L+ EL+E              VL+ +  L+++   L+ + D +K
Sbjct: 673  EKTLEKLDVKQTELESLSSELSE--------------VLKARHKLEEELSVLKDQTDKMK 718

Query: 64   QELEQLKEAFGQSFSIHRKVAEDGETREETLLQ--ESASKEAYYLGKIL--EMQNELKQS 119
            QELE   +   +  + H++  +      E  +Q  E A K+     ++L  E    LK+ 
Sbjct: 719  QELEAKMD---EQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEH 775

Query: 120  RAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEEN 179
            +A V N++A+ +R    +Q      ++ +  +    ++ + Y+ + A+L Q   +LE E 
Sbjct: 776  QAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETER 835

Query: 180  ITLQKLVSTLKQNQ----VEYEGLKHEIKRFEEETVLLNSQLEDAIR-LKEIAEHQLEEA 234
            I L K V+ ++  +     E +  K +++   ++    NS++E  ++ L ++ E +LE+ 
Sbjct: 836  ILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDG 895

Query: 235  ---LETLKNEREQKNN----LRKELSQYISLNDNHISISVDGLKFAEDGSE---PNNDDK 284
                E  K    +K N    +R+   + I +    +S   D +    +  E    N + K
Sbjct: 896  NKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKK 955

Query: 285  MNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEI---QKLKQQLMQVEREKA 341
            M        VK        TL+K + L+  + L  EL  + +   QK KQ   ++     
Sbjct: 956  ME------KVKQKAKEMQETLKK-KLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQ 1008

Query: 342  ILLANLQESQTQLEHTKGALTEQHERVHRLTE-HVNAMRGLQSSKELKAELDGEKGRDSG 400
               A + ++ ++LE      T Q E++  LTE H   +  + S  E K     E+     
Sbjct: 1009 ANSAGISDAVSRLE------TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEE----L 1058

Query: 401  EEAHDYEVDINGLEILECKYRVAV--TEVIDLKAEIKALKE-------------KYNKSV 445
            +E H+ ++     E+ E K ++ +   E  ++  EI  LKE             +  K  
Sbjct: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQK 1118

Query: 446  ENYTDEKAKYESKIQMYDEQV-TSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTA 504
              + +  A+ E+K++ + E++   L K+ KE+      ++++L ++  +A E+   ++  
Sbjct: 1119 SAHVNSLAQDETKLKAHLEKLEVDLNKSLKEN----TFLQEQLVELKMLAEEDKRKVSEL 1174

Query: 505  QDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLA 564
              +L T  EE   L       N    ++  L++ + S                LL  +  
Sbjct: 1175 TSKLKTTDEEFQSLKSSHEKSNKSLEDK-SLEFKKLSEELAIQLDICCKKTEALLEAKTN 1233

Query: 565  RRGVSSPVETRTSSEPVA--KESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEP 622
                 S  +T      ++  +  T   KE    KT T+S +            + +R+  
Sbjct: 1234 ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSEL-----------EAQLRQLT 1282

Query: 623  MNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLS 682
                 LN   +     L+   ++  Q+   +A    L      +KEAL +E    +   S
Sbjct: 1283 EEQNTLNISFQQATHQLE---EKENQIKSMKADIESLV----TEKEALQKEGGNQQQAAS 1335

Query: 683  TKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELK---ALKEDAA 739
             K   I  L+  L  N     +    LK K + E + +++ +T L  +L+   +L E  A
Sbjct: 1336 EKESCITQLKKELSENINAVTLMKEELKEK-KVEISSLSKQLTDLNVQLQNSISLSEKEA 1394

Query: 740  TFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEK 773
              SSLR  +     E + Q+ ++  ++     EK
Sbjct: 1395 AISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEK 1428



 Score = 81.6 bits (200), Expect = 3e-15
 Identities = 155/852 (18%), Positives = 339/852 (39%), Gaps = 147/852 (17%)

Query: 14   KTEIERLTKELTETT---HEKIQAAEYGLVVL-------EEKLTLKQQYDELEAEYDSLK 63
            K EI  L+K+LT+        I  +E    +        EEK  L  Q  +L  + D+L 
Sbjct: 1366 KVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLS 1425

Query: 64   QE----LEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQS 119
            +E    LEQ+ + +   FS  +K A+   T+ +  ++E            L++Q ELK  
Sbjct: 1426 KEKISALEQVDD-WSNKFSEWKKKAQSRFTQHQNTVKE------------LQIQLELKSK 1472

Query: 120  RAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEEN 179
             A       ++E++  + ++L + N+  +  +  M+D+  + + +E+ L    TEL+ + 
Sbjct: 1473 EAY-----EKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL---ETELKSQT 1524

Query: 180  ITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLK 239
              + +L   + Q  +E E L   +K + ++              K+I   +L + L+  +
Sbjct: 1525 ARIMELEDHITQKTIEIESLNEVLKNYNQQ--------------KDIEHKELVQKLQHFQ 1570

Query: 240  NEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGD 299
               E+K+N  KE  + I   +N     V  +K     +E     K   H++         
Sbjct: 1571 ELGEEKDNRVKEAEEKILTLEN----QVYSMK-----AELETKKKELEHVN--------- 1612

Query: 300  YRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQ-VEREKAILLANLQESQTQ----- 353
                   K E L  + D     + +++ +LK++  Q +   K  LL+ ++E + Q     
Sbjct: 1613 --LSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGT 1670

Query: 354  ---LEHTKGALTEQHERVHRLTEHVNAMRGLQ--------SSKELKAELDGEKGRDSGEE 402
               L      L E+   VH L E + ++   Q        S+K + A  + E+    G  
Sbjct: 1671 ESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCV 1730

Query: 403  AHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKI--- 459
               YE  I+ L+            + + +  ++ + ++  ++V ++ + + +Y+ ++   
Sbjct: 1731 QKTYEEKISVLQ----------RNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKL 1780

Query: 460  -----QMYDEQ--VTSLEKTTKESGEKMA-----HMEKE-----LQKMTSIANENHSTLN 502
                 + +++Q  +  L++  +E  +K +     H+EKE     +Q   ++ N       
Sbjct: 1781 EHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQK 1840

Query: 503  TAQDELVT---FSEELAQLYHHVCLCNNETPNRVMLDYY--RQSRVTRSGSLKGPDDPRG 557
            T Q++ +T     +++ +L    CL   +  +RV ++    +  ++     + G + P  
Sbjct: 1841 TLQEKELTCQILEQKIKEL--DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTE 1898

Query: 558  LLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSD 617
            LL      +  S  V+ +  S   A+ +    K     +                 +   
Sbjct: 1899 LLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAER-----------------EKQK 1941

Query: 618  IRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKL 677
            + KE + +     ++R + +   + + +     R+    +E   +  K    L + + + 
Sbjct: 1942 LGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREF 2001

Query: 678  KSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELK-ALKE 736
             + L+ K ++   L   +K     A+   A L   ++ E   + + + +  ++LK   K 
Sbjct: 2002 NTQLAQKEQE---LEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKR 2058

Query: 737  DAATFSSLRAMFATRCDEYVTQLDEMQR--QLAAAEDEKKTLNTLLRMAIQQKLA-LTQR 793
                  +       +  +  TQL+E+Q+  Q    ++E    + +  M +Q +LA  T  
Sbjct: 2059 YEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTL 2118

Query: 794  LEDLEFDHEQSR 805
            + D +   ++ R
Sbjct: 2119 ISDSKLKEQEFR 2130



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 153/813 (18%), Positives = 342/813 (42%), Gaps = 93/813 (11%)

Query: 16   EIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQEL-EQLKEAFG 74
            E+ R+ +E+ +   +  +     L  L EK  L ++  EL  +  + ++E  EQ+K A  
Sbjct: 458  ELSRVKQEVVDVMKKSSEEQIAKLQKLHEK-ELARKEQELTKKLQTREREFQEQMKVALE 516

Query: 75   QSFSIHRKVAEDGETREETLLQESASKEAYYL----GKILEMQNELKQSRAVVTNVQAEN 130
            +S S + K++++ E +E   L+E   ++   L     K+ ++Q E +  R  +  +++  
Sbjct: 517  KSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSL 576

Query: 131  ERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDY-TELE-----EENITLQK 184
            E+       L+EN    +   + ++ E  ++      +++ + TELE     ++ +  +K
Sbjct: 577  EK------SLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEK 630

Query: 185  LVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQ 244
            L    +Q Q E E L+ + ++ E+ET+L + ++     ++E+     E+ LE L  ++ +
Sbjct: 631  LQVLKQQYQTEMEKLREKCEQ-EKETLLKDKEIIFQAHIEEMN----EKTLEKLDVKQTE 685

Query: 245  KNNLRKELSQYISLN---DNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYR 301
              +L  ELS+ +      +  +S+  D     +   E   D++ N H            +
Sbjct: 686  LESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHH----------QQQ 735

Query: 302  TPTLRKGESLNPVSDLFSELNISEIQK-LKQQLMQVEREKAILLANLQESQTQLEHTKGA 360
              ++ K            E++I   +K LK Q+ Q+E        +L+E Q  +E+ +  
Sbjct: 736  VDSIIKEH----------EVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEAD 785

Query: 361  LTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKY 420
            +      + + +  ++  +  QS+   + +   E+     ++  D E +     IL  K 
Sbjct: 786  IKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE----RILLTK- 840

Query: 421  RVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKM 480
               V EV   K ++    + +   V++   +  K  S+++   + +T + ++  E G K 
Sbjct: 841  --QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK- 897

Query: 481  AHMEKELQKMTSIANENH--STLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYY 538
               E+E  K   +  EN         + E+   +++L+     + + N E   +      
Sbjct: 898  ---EQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK 954

Query: 539  RQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTP 598
            +  +V +             +   L ++ +    + +   E  A E ++  K+ +  K  
Sbjct: 955  KMEKVKQKAK---------EMQETLKKKLLDQEAKLKKELENTALELSQKEKQFN-AKML 1004

Query: 599  TISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARE 658
             ++   +A  S  V      +KE   I +L  + R ++  +    ++  +L++Q    +E
Sbjct: 1005 EMAQANSAGISDAVSRLETNQKE--QIESLTEVHRRELNDVISIWEK--KLNQQAEELQE 1060

Query: 659  LAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKA 718
            +  +  ++KE  + E+ +   L   ++E++      LK      +  L  L+ + + + A
Sbjct: 1061 IHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSA 1120

Query: 719  MV---TETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKT 775
             V    +  TKL+  L+ L+ D     SL+       +    Q   ++ ++ A ED++K 
Sbjct: 1121 HVNSLAQDETKLKAHLEKLEVDLN--KSLK-------ENTFLQEQLVELKMLAEEDKRKV 1171

Query: 776  LNTLLRMAIQQKLALT-QRLEDLEFDHEQSRRS 807
                    +  KL  T +  + L+  HE+S +S
Sbjct: 1172 ------SELTSKLKTTDEEFQSLKSSHEKSNKS 1198



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 178/905 (19%), Positives = 356/905 (39%), Gaps = 178/905 (19%)

Query: 5    EVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ 64
            + L+T+       E L K   ET        E   ++  EK  L++Q DE   E + +K 
Sbjct: 279  KTLETLQQRVKRQENLLKRCKETIQSH---KEQCTLLTSEKEALQEQLDERLQELEKIKD 335

Query: 65   E------------------LEQLKEAFGQSFS-IHRKVAEDGETREETLLQ-ESASKEAY 104
                               +EQL++  G   +   R++ E  E +EE + Q  S  K+  
Sbjct: 336  LHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMT 395

Query: 105  YLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFR 164
              G+ L  Q E K  RA       E E+  +  Q  +E        R ++K E+ E    
Sbjct: 396  TQGEELREQKE-KSERAAFE----ELEKALSTAQKTEE-------ARRKLKAEMDE---- 439

Query: 165  EARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLK 224
            + + ++  +E  EE I+LQ+ +S +KQ  V+       +K+  EE +    +L +    K
Sbjct: 440  QIKTIEKTSE--EERISLQQELSRVKQEVVDV------MKKSSEEQIAKLQKLHE----K 487

Query: 225  EIA--EHQLEEALETLKNE--REQKNNLRKELSQYISLN---DNHISISVDGLKFAEDGS 277
            E+A  E +L + L+T + E   + K  L K  S+Y+ ++   +   S++++ L+  +   
Sbjct: 488  ELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAI 547

Query: 278  EPNNDDKMNG-----------------------------------HIHGPLVKLNGDYRT 302
               +++K+                                     H+     K N +   
Sbjct: 548  LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV 607

Query: 303  PTLRKGESLNPVSDLFSELNISEIQKLKQQLM--------QVEREKAILL--------AN 346
               +    L  +      L   ++Q LKQQ          + E+EK  LL        A+
Sbjct: 608  MVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAH 667

Query: 347  LQE-----------SQTQLEHTKGALTEQHERVHRLTEHVNAMRGL--QSSKELKAELDG 393
            ++E            QT+LE     L+E  +  H+L E ++ ++    +  +EL+A++D 
Sbjct: 668  IEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDE 727

Query: 394  EKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKA 453
            +K        H  +VD            +     + ++   KALK++ N+ +E    E+ 
Sbjct: 728  QKNH------HQQQVD-----------SIIKEHEVSIQRTEKALKDQINQ-LELLLKERD 769

Query: 454  KYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSE 513
            K+   ++ +   V +LE   K S       E ELQ+ ++  +   S  +   ++   + E
Sbjct: 770  KH---LKEHQAHVENLEADIKRS-------EGELQQASAKLDVFQSYQSATHEQTKAYEE 819

Query: 514  ELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPR---GLLSPRLARRGVSS 570
            +LAQL     L + ET   ++     +    +       D  +     L  +L ++    
Sbjct: 820  QLAQLQQK--LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEM 877

Query: 571  PVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNA 630
              + ++ ++    +  + +KE   TK       I     + +L   + +K+ + I     
Sbjct: 878  EQKVKSLTQVYESKLEDGNKEQEQTKQ------ILVEKENMILQMREGQKKEIEILTQKL 931

Query: 631  IIRDQIKHL------QKAVDRSLQLSRQRAAARELAPMIDK---DKEALMEEILKLKSL- 680
              ++   H+       K  ++  ++ + +  A+E+   + K   D+EA +++ L+  +L 
Sbjct: 932  SAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALE 991

Query: 681  LSTKREQI-ATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNEL-----KAL 734
            LS K +Q  A +  + +AN      A++ L+   + +   +TE   +  N++     K L
Sbjct: 992  LSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKL 1051

Query: 735  KEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDE-KKTLNTLLRMAIQQKLALTQR 793
             + A     +  +     ++ V +L +        ++E  K +  L    ++Q   L + 
Sbjct: 1052 NQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNEL 1111

Query: 794  LEDLE 798
             E L+
Sbjct: 1112 QEQLK 1116



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 148/735 (20%), Positives = 299/735 (40%), Gaps = 144/735 (19%)

Query: 95  LQESASKEAYYLGKILEMQNELKQSRAVVT-----NVQAENERLTAVVQDLKENNEMVEL 149
           L  S+SKE+       E  N L    +  +     ++ +E E L      L  N E +  
Sbjct: 84  LFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSL--NKEQLIQ 141

Query: 150 QRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEE 209
           +  RM+  +  Y+ + + L+  Y  L+ E   LQ ++S                 + +++
Sbjct: 142 RLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILS-----------------QSQDK 184

Query: 210 TVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDG 269
           ++   ++L + +++ + A+  L+E  +    E++Q          YIS+    +S+    
Sbjct: 185 SLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQ----------YISVLQTQVSLLKQR 234

Query: 270 LKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRT------------PTLRKGESLNPVSDL 317
           L+          +  MN  +  PL +L                  P +  G S+  +  L
Sbjct: 235 LR----------NGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETL 284

Query: 318 FSELNISE-IQKLKQQLMQVEREKAILLANLQES-QTQLEHTKGALTEQHERVHRLTEHV 375
              +   E + K  ++ +Q  +E+  LL + +E+ Q QL+     L E+ + +H + E  
Sbjct: 285 QQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQEL-EKIKDLH-MAEKT 342

Query: 376 NAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIK 435
             +  L+ +K L  +L+ +KG    E            E LE K      E+  L++ IK
Sbjct: 343 KLITQLRDAKNLIEQLEQDKGMVIAETKRQMH------ETLEMKEE----EIAQLRSRIK 392

Query: 436 ALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKM-AHMEKELQKMTSIA 494
            +  +     E   ++K K E       E+  S  + T+E+  K+ A M+++++ +    
Sbjct: 393 QMTTQG----EELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEK-- 446

Query: 495 NENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDD 554
                   T+++E ++  +EL+++   V            +D  ++S   +   L+    
Sbjct: 447 --------TSEEERISLQQELSRVKQEV------------VDVMKKSSEEQIAKLQK--- 483

Query: 555 PRGLLSPRLARRG--VSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPV 612
              L    LAR+   ++  ++TR   E   +E  + + E S ++   IS        S  
Sbjct: 484 ---LHEKELARKEQELTKKLQTR---EREFQEQMKVALEKSQSEYLKISQE-KEQQESLA 536

Query: 613 LDTSDIRKEPMNIYNLNAI---------IRDQIKHLQKAVDRSLQLSRQRAAARELAPMI 663
           L+  +++K+ +   + N +          R +I  L+ ++++SLQ ++ ++  ++LA  +
Sbjct: 537 LEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQS--KDLAVHL 594

Query: 664 DKDKEALMEEILKL-----KSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKA 718
           + +K    +EI  +       L S K +Q A     L+  KQ  +  +  L+ K E EK 
Sbjct: 595 EAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKE 654

Query: 719 ----------------MVTETMTKL---RNELKALKEDAATFSSLRAMFATRCDEYVTQL 759
                           M  +T+ KL   + EL++L  + +     R            Q 
Sbjct: 655 TLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQT 714

Query: 760 DEMQRQLAAAEDEKK 774
           D+M+++L A  DE+K
Sbjct: 715 DKMKQELEAKMDEQK 729



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 111/549 (20%), Positives = 219/549 (39%), Gaps = 79/549 (14%)

Query: 1    MAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYD 60
            +A +E        K E++ L K L E T  + Q  E  ++  E+K    ++  EL ++  
Sbjct: 1125 LAQDETKLKAHLEKLEVD-LNKSLKENTFLQEQLVELKMLAEEDK----RKVSELTSKLK 1179

Query: 61   SLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSR 120
            +  +E + LK +  +S     K  ED     + L +E A          +++    K++ 
Sbjct: 1180 TTDEEFQSLKSSHEKS----NKSLEDKSLEFKKLSEELA----------IQLDICCKKTE 1225

Query: 121  AVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENI 180
            A++       E  T  + ++  +     L RI      R  K +EA L++  T  E E  
Sbjct: 1226 ALL-------EAKTNELINISSSKTNAILSRISHCQH-RTTKVKEALLIKTCTVSELE-A 1276

Query: 181  TLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKN 240
             L++L        + ++   H+++  E +   + + +E  +  KE  + +     +    
Sbjct: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE 1336

Query: 241  EREQKNNLRKELSQYISLNDNHISISVDGL--KFAEDGSEPNNDDKMNGHIHGPLVKLNG 298
            +      L+KELS+    N N +++  + L  K  E  S       +N  +   +     
Sbjct: 1337 KESCITQLKKELSE----NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEK 1392

Query: 299  DYRTPTLRKG------ESLNPVSDL------FSELNISEIQ-------KLKQQLMQVERE 339
            +    +LRK       E L+ V DL       S+  IS ++       K  +   + +  
Sbjct: 1393 EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSR 1452

Query: 340  KAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKE---LKAELDGEKG 396
                   ++E Q QLE       E+ E+++ L E ++     Q +K    LK E++ +K 
Sbjct: 1453 FTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELD-----QQNKRFDCLKGEMEDDKS 1507

Query: 397  RDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEI--KALK-EKYNKSVENYTDEK- 452
            +   +E++           LE + +     +++L+  I  K ++ E  N+ ++NY  +K 
Sbjct: 1508 KMEKKESN-----------LETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKD 1556

Query: 453  ---AKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELV 509
                +   K+Q + E     +   KE+ EK+  +E ++  M +        L      + 
Sbjct: 1557 IEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVK 1616

Query: 510  TFSEELAQL 518
            +  EEL  L
Sbjct: 1617 SKEEELKAL 1625



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 76/389 (19%), Positives = 156/389 (40%), Gaps = 65/389 (16%)

Query: 10   VDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDS-------L 62
            + H + E+E   K+ +    + ++  E G   ++ K  L+  +D+++            L
Sbjct: 1794 IGHLQEELEEKNKKYSLIVAQHVEK-EGGKNNIQAKQNLENVFDDVQKTLQEKELTCQIL 1852

Query: 63   KQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAV 122
            +Q++++L     +   +HR   E+  ++ E L             ++LE   E K    +
Sbjct: 1853 EQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHL 1912

Query: 123  V-----TNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIR----EYKFREARLLQDYT 173
            V     +N++A++  L   +   +   + +  + +R++ ++R    E++     L ++Y 
Sbjct: 1913 VQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYD 1972

Query: 174  ELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEE 233
            +  EE I  ++    LK N      LK  ++ F  +      +LE  + +KE      E 
Sbjct: 1973 QEREEKIKQEQEDLELKHNST----LKQLMREFNTQLAQKEQELE--MTIKETINKAQEV 2026

Query: 234  ALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPL 293
              E L++ +E+ N L K+++                        E ++D K     +  +
Sbjct: 2027 EAELLESHQEETNQLLKKIA------------------------EKDDDLKRTAKRYEEI 2062

Query: 294  VKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQ 353
            +           R+ E    V DL ++L   E+QK  QQ ++ E         + E QTQ
Sbjct: 2063 LDA---------REEEMTAKVRDLQTQLE--ELQKKYQQKLEQEENPGNDNVTIMELQTQ 2111

Query: 354  LEH-----TKGALTEQ--HERVHRLTEHV 375
            L       +   L EQ   E++H L + +
Sbjct: 2112 LAQKTTLISDSKLKEQEFREQIHNLEDRL 2140



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 51/208 (24%), Positives = 93/208 (44%), Gaps = 28/208 (13%)

Query: 13   YKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQ-LKE 71
            ++ E+E L KE  +   EKI+  +  L  L+   TLKQ   E   +    +QELE  +KE
Sbjct: 1960 HQQELEILKKEYDQEREEKIKQEQEDLE-LKHNSTLKQLMREFNTQLAQKEQELEMTIKE 2018

Query: 72   AFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNV-QAEN 130
               ++  +  ++ E  +     LL+           KI E  ++LK++      +  A  
Sbjct: 2019 TINKAQEVEAELLESHQEETNQLLK-----------KIAEKDDDLKRTAKRYEEILDARE 2067

Query: 131  ERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLK 190
            E +TA V+DL+   ++ ELQ+          K+++   L+       +N+T+ +L + L 
Sbjct: 2068 EEMTAKVRDLQ--TQLEELQK----------KYQQK--LEQEENPGNDNVTIMELQTQLA 2113

Query: 191  QNQVEYEGLKHEIKRFEEETVLLNSQLE 218
            Q        K + + F E+   L  +L+
Sbjct: 2114 QKTTLISDSKLKEQEFREQIHNLEDRLK 2141


>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
          Length = 2017

 Score = 89.4 bits (220), Expect = 1e-17
 Identities = 160/814 (19%), Positives = 326/814 (40%), Gaps = 102/814 (12%)

Query: 7    LQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQEL 66
            +Q  +  + E++RL       + EK   A    V  ++   L+Q+ ++L+A  + L+++ 
Sbjct: 581  MQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQR 640

Query: 67   EQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNV 126
            ++L+E    +     +V  + E R    L++   K +    +++E++  L ++      +
Sbjct: 641  DRLEEEQEDAVQDGARVRRELE-RSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDML 699

Query: 127  QAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLV 186
            QAE   +   +   +     +EL   +++ E    +   ++L      L ++ + L +LV
Sbjct: 700  QAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLV 759

Query: 187  STL---------KQNQVEYEGL--KHEIKRFEE---ETVLLNSQLEDAIRLKEIAEHQLE 232
            + L         +Q Q E E    + E +R EE   E  +    LE ++R+ E A+  LE
Sbjct: 760  AQLEEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALE 819

Query: 233  EALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSE--PNNDDKMNGHIH 290
            + L TL++ER Q      +LS+ +S  +  +  +    +   +  E      + +     
Sbjct: 820  QQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHA 879

Query: 291  GPLVKLNGDYRTPTLRKGESLNPVSD---LFSELNISEIQKLKQQLMQVEREKAILLANL 347
            G  V+L         R+G +L+  +    L  E     + ++++QL Q+E  +  L A  
Sbjct: 880  GLAVQL-----VAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEG 934

Query: 348  QESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYE 407
            Q      E   G L    +++    E  +  + L + K ++AE + +        AH+  
Sbjct: 935  QALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHE-- 992

Query: 408  VDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVT 467
                                     +++ L+ +   +      E+A+ +S++Q   E++ 
Sbjct: 993  ------------------------EDLQRLQREKEAAWRELEAERAQLQSQLQREQEELL 1028

Query: 468  S-LEKTTKESGEKMAHMEKELQKMTSIA-NENHSTLNTAQDELVTFSEELAQLYHHVCLC 525
            + LE   +E  E++A +++E  +   +A +E    L+  + E    SE+L    H +   
Sbjct: 1029 ARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLA-- 1086

Query: 526  NNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKES 585
                   + L+  RQ R  +S   +       L S     R                +E 
Sbjct: 1087 ------TISLEMERQKRDAQSRQEQDRSTVNALTSELRDLR--------------AQREE 1126

Query: 586  TEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDR 645
              A+      +    +  +     S + +  ++R +   + +    +R ++   Q+ +  
Sbjct: 1127 AAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE 1186

Query: 646  SLQ-LSRQRAAARELAPMID---KDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQT 701
            S +    QR  A EL   +    K++EAL     +L+S             AV KA  + 
Sbjct: 1187 SQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRS-------------AVKKAESER 1233

Query: 702  AEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDE 761
              + LAN     E + A++ E  T +  E   L+      + L+ +  +R  E   +L E
Sbjct: 1234 ISLKLAN--EDKEQKLALLEEARTAVGKEAGELR------TGLQEVERSRL-EARRELQE 1284

Query: 762  MQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLE 795
            ++RQ+   + E   L   L   +Q +LAL +R E
Sbjct: 1285 LRRQMKMLDSENTRLGREL-AELQGRLALGERAE 1317



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 170/854 (19%), Positives = 331/854 (38%), Gaps = 87/854 (10%)

Query: 3    AEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSL 62
            AEE+   +   +   + L +EL E   +  ++ E   V  +E   L++   E   E ++L
Sbjct: 1156 AEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREAL 1215

Query: 63   KQELEQLKEAF--GQSFSIHRKVAEDGETREETLLQESASKEAYYLGKI----------- 109
            ++  E+L+ A    +S  I  K+A + + ++  LL+E+ +      G++           
Sbjct: 1216 RRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSR 1275

Query: 110  LEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLL 169
            LE + EL++ R  +  + +EN RL    ++L E    + L     K+  RE      RLL
Sbjct: 1276 LEARRELQELRRQMKMLDSENTRLG---RELAELQGRLALGERAEKESRRETLGLRQRLL 1332

Query: 170  QDYTELEEENITLQKLVSTLKQNQVEYEGLKHE-IKRFEEETVLLNSQLEDAIRLKEIAE 228
            +    LE     LQ     L++ + E+   +   +   EE       QL+ A  L+   E
Sbjct: 1333 KGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLE 1392

Query: 229  HQLEEALE---TLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFA------------ 273
                EA E    L     +   L  EL++ + +        + GL+ A            
Sbjct: 1393 AARAEAAELGLRLSAAEGRAQGLEAELAR-VEVQRRAAEAQLGGLRSALRRGLGLGRAPS 1451

Query: 274  ----EDGSEPNNDDKMNGHIHG----PLVKLNGDYRTPTLRKGESLNPVS-DLFSELNIS 324
                     P  D    G   G      ++ +   + P+   G + +P S DL  E    
Sbjct: 1452 PAPRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPS--PGPATSPASPDLDPEAVRG 1509

Query: 325  EIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSS 384
             +++  Q+L   +RE+  L         QL   +        R  +L       + +  S
Sbjct: 1510 ALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQL------QKAVAES 1563

Query: 385  KELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKS 444
            +E +  +D   GR SG +A +  +    +   E + R  + +V  L+  ++A + +   S
Sbjct: 1564 EEARRSVD---GRLSGVQA-ELALQEESVRRSERERRATLDQVATLERSLQATESELRAS 1619

Query: 445  VENYTDEKA---KYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTL 501
             E  +  KA   K E   +   E + + E  T +   +   +E ELQ+     ++  +  
Sbjct: 1620 QEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQA 1679

Query: 502  NTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSP 561
               QD + +   ++A              + V     + +    +G+L   ++  G L  
Sbjct: 1680 QALQDRVDSLQRQVAD-------------SEVKAGTLQLTVERLNGALAKVEESEGALRD 1726

Query: 562  RLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKE 621
            ++  RG++  +  ++S+   +        + + T       V+     +     S+ RK+
Sbjct: 1727 KV--RGLTEAL-AQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQ 1783

Query: 622  PMNIYNLNAIIRDQIKHLQ-KAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSL 680
              ++      +R ++  L+ + V+   QL + R   R+      + + A +  + KL+  
Sbjct: 1784 SSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQR----QEGEAAALNTVQKLQDE 1839

Query: 681  LSTKREQIATL-RAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAA 739
                +E++ +L RA+ +   +  EV  + L  + E ++  +  T+ K+  E     ED  
Sbjct: 1840 RRLLQERLGSLQRALAQLEAEKREVERSAL--RLEKDRVALRRTLDKVEREKLRSHEDTV 1897

Query: 740  TFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLN------TLLRMAIQQKLALTQR 793
              S+ +            +L E QRQ+   E +   L        L   A QQ+L L Q 
Sbjct: 1898 RLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQE 1957

Query: 794  LEDLEFDHEQSRRS 807
            +E L     Q+ R+
Sbjct: 1958 VERLRSAQAQTERT 1971



 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 156/793 (19%), Positives = 307/793 (38%), Gaps = 77/793 (9%)

Query: 47   TLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREET--LLQESASKEAY 104
            TL++Q  + E+E  +L+++L++L++    +   H     + +       LL    S  A+
Sbjct: 551  TLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAH 610

Query: 105  YLGKILEMQNELKQSRAVVTNVQAE----NERLTAVVQDLKENNEMVELQRIRMKDEIRE 160
             L    +   EL+Q R  +   Q E     +RL    +D  ++   V  +  R   ++ +
Sbjct: 611  SLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQ 670

Query: 161  YKFREARLLQDYTELEE--ENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLE 218
             + + + L ++  E+ E     TLQ+ +   ++ +V     K E  R E E  +   + E
Sbjct: 671  LEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAE 730

Query: 219  DAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSE 278
            +A     +++  L    E+L  ++   N L  +L +  S        +      A +  E
Sbjct: 731  EASLQDSLSK--LSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQE 788

Query: 279  PNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVER 338
               + ++   +      L G  R            V++   E    ++  L+ +  Q++ 
Sbjct: 789  RLEELRLEQEVARQ--GLEGSLR------------VAEQAQEALEQQLPTLRHERSQLQE 834

Query: 339  EKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRD 398
            + A L   L   + +LE  +     Q E + R      A+    +   ++      +GR 
Sbjct: 835  QLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRT 894

Query: 399  SGEEAHDYEVDINGLE--ILECKYRVAVTEV--IDLKAEIKAL---KEKYNKSVENY--- 448
              EEA    ++   LE  + E + ++A  E     L+AE +AL   KE     +      
Sbjct: 895  LSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQ 954

Query: 449  ---TDEKAKYESK------IQMYDEQVTSLEKTTKESGEKMAHMEKELQ----KMTSIAN 495
               T EKA  + +      +Q   E   SL +      E +  +++E +    ++ +   
Sbjct: 955  IIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERA 1014

Query: 496  ENHSTLNTAQDELVTFSE-ELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDD 554
            +  S L   Q+EL+   E E  +L   +     E    ++L    +S   ++ SLK  + 
Sbjct: 1015 QLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLL---AESEKQQALSLK--ES 1069

Query: 555  PRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLD 614
             +  LS +L        + TR S   ++ E     ++    +    S V     +S + D
Sbjct: 1070 EKTALSEKL--------MGTRHSLATISLEMERQKRDAQSRQEQDRSTVNAL--TSELRD 1119

Query: 615  TSDIRKEPMNIYNLNA-IIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEE 673
                R+E    +      +++Q + L K  D  L   R+    R    +++  ++ L  E
Sbjct: 1120 LRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCL---REAEELRTQLRLLEDARDGLRRE 1176

Query: 674  ILKLKSLL-------STKREQIATLRAVL-KANKQTAEVALANLKNKYENEKAMVTETMT 725
            +L+ +  L         +R++   LR  L +  K+   +  +N + +   +KA       
Sbjct: 1177 LLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISL 1236

Query: 726  KLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQ 785
            KL NE K  ++  A     R        E  T L E++R    A  E + L   ++M   
Sbjct: 1237 KLANEDK--EQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDS 1294

Query: 786  QKLALTQRLEDLE 798
            +   L + L +L+
Sbjct: 1295 ENTRLGRELAELQ 1307



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 202/972 (20%), Positives = 354/972 (36%), Gaps = 211/972 (21%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTHE-KIQAAEYGLVVLEEKLT--------LKQQYDE 54
            E  +   +  + E  RL +E+     E  ++ AE     LE++L         L++Q  +
Sbjct: 779  EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQ 838

Query: 55   LEAEYDSLKQELEQL-KEAFGQSFSIHRKVAE--------------------DGETREET 93
            L  +    +QELEQ  +EA  Q  ++ R   E                    +G T  E 
Sbjct: 839  LSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEE 898

Query: 94   LLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIR 153
              +    KEA   G + E+Q +L Q  A    ++AE + L    + L    E+  L+   
Sbjct: 899  ATRLRLEKEALE-GSLFEVQRQLAQLEARREQLEAEGQALLLAKETL--TGELAGLR--- 952

Query: 154  MKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLL 213
                      ++    Q+   L++E +  QKLV   ++ Q     L+ +    EE+   L
Sbjct: 953  ----------QQIIATQEKASLDKE-LMAQKLVQAEREAQA---SLREQRAAHEEDLQRL 998

Query: 214  NSQLEDAIRLKEIAEHQLEEAL-----ETLKNEREQKNNLRKELSQYISLNDNHISISVD 268
              + E A R  E    QL+  L     E L     +K  L +E++      D  + ++  
Sbjct: 999  QREKEAAWRELEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAES 1058

Query: 269  GLKFA---EDGSEPNNDDKMNGHIHGPL---VKLNGDYRTPTLRKGESLNPVSDLFSEL- 321
              + A   ++  +    +K+ G  H      +++    R    R+ +  + V+ L SEL 
Sbjct: 1059 EKQQALSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELR 1118

Query: 322  ------------NISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVH 369
                        +  E+++L++Q   + +++   L   +E +TQL      L +  + + 
Sbjct: 1119 DLRAQREEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLR----LLEDARDGLR 1174

Query: 370  R-LTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVI 428
            R L E    +R  Q  +E++ +  GE  R  GE A + E      E L    + A +E I
Sbjct: 1175 RELLEAQRKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERI 1234

Query: 429  DLKAEIKALKEKYNKSVENYTD---------------EKAKYESK--IQMYDEQVTSLEK 471
             LK   +  ++K     E  T                E+++ E++  +Q    Q+  L+ 
Sbjct: 1235 SLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDS 1294

Query: 472  TTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNE--- 528
                 G ++A ++  L        E+       +  L+     L  +   + +   +   
Sbjct: 1295 ENTRLGRELAELQGRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQE 1354

Query: 529  ------TPNRVMLDYYRQSRVTRSGSLKGPDDPRGL-------------LSPRL-ARRGV 568
                  T  R +L    ++R T    L   D  RGL             L  RL A  G 
Sbjct: 1355 QEGEFRTRERRLLGSLEEARGTEKQQL---DHARGLELKLEAARAEAAELGLRLSAAEGR 1411

Query: 569  SSPVETRTSSEPVAKESTEA---------------SKEPSPTKTPTI-SPVITAP----- 607
            +  +E   +   V + + EA                + PSP   P   SP   AP     
Sbjct: 1412 AQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSG 1471

Query: 608  -------------------------PSSPVLDTSDIR--------------KEPMNIYNL 628
                                     P+SP LD   +R              +E   +   
Sbjct: 1472 EGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELRTQ 1531

Query: 629  NAIIRDQIKHLQ----KAVDRSLQLSRQRAAARELAPMIDKDKEALMEEI-LKLKSLLST 683
             + +  Q+  ++     A  R+ QL +  A + E    +D     +  E+ L+ +S+  +
Sbjct: 1532 TSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRS 1591

Query: 684  KREQIATLR--AVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKE--DAA 739
            +RE+ ATL   A L+ + Q  E  L   + K    KA      TKL  + + LKE  DA+
Sbjct: 1592 ERERRATLDQVATLERSLQATESELRASQEKISKMKA----NETKLEGDKRRLKEVLDAS 1647

Query: 740  TFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEF 799
               +++               E+QR+    E ++  L    R A  Q  AL  R++ L+ 
Sbjct: 1648 ESRTVKL--------------ELQRRSLEGELQRSRLGLSDREA--QAQALQDRVDSLQR 1691

Query: 800  DHEQSRRSKGKL 811
                S    G L
Sbjct: 1692 QVADSEVKAGTL 1703



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 156/766 (20%), Positives = 290/766 (37%), Gaps = 117/766 (15%)

Query: 138 QDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTE------LEEENITLQKLVST--- 188
           +DL ++ ++  L  +  +   R     E+ +L   TE      L+EEN  LQ+ +S    
Sbjct: 36  RDLAQDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVED 95

Query: 189 -LKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLK----EIAEHQ--LEEALETLKNE 241
            L Q++ E + L  +     E       +LE A+RL+    E  E +  + +++E  +  
Sbjct: 96  LLAQSRAERDELAIKYNAVSE-------RLEQALRLEPGELETQEPRGLVRQSVELRRQL 148

Query: 242 REQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYR 301
           +E++ + R++L  Y         + V  L+      +     K    +   L++ +G+  
Sbjct: 149 QEEQASYRRKLQAYQEGQQRQAQL-VQRLQ-----GKILQYKKRCSELEQQLLERSGELE 202

Query: 302 TPTLRKGESLNPVSDLFSELNISEIQK---------LKQQLMQVEREKAILLANLQE--- 349
              LR  E    +      L   + +          L++QL Q       L  ++++   
Sbjct: 203 QQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTN 262

Query: 350 ----SQTQLEHTKGA-----------LTEQHERVHRLTEHVNAMRGLQSSKELKAELD-- 392
                + +LEH + A            + +H R+  L   V   R L S  ++  E D  
Sbjct: 263 DWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLL 322

Query: 393 ---GEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEI------KALKEKYNK 443
              GE  R S            GL + E +   A+ +   L+A++      K L+EK   
Sbjct: 323 QLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLA 382

Query: 444 SVENYTD-EKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLN 502
             +  +D +KA   +++      V  LEK   E  +    + ++L+ + S+  +  + L 
Sbjct: 383 QQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALE 442

Query: 503 TAQDE-LVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSP 561
           T   E L     +LAQ               V+ D   +S V  SGS +  D   G L  
Sbjct: 443 TEDGEGLQQTLRDLAQ--------------AVLSD--SESGVQLSGSERTADASNGSLRG 486

Query: 562 RLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITA--------------- 606
              +R  S P      S P    S      P+ + + T++ + +A               
Sbjct: 487 LSGQRTPSPP----RRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRY 542

Query: 607 PPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKD 666
             S  +L T  +RK+  +  +    + +Q++ L+   D ++Q      A RE+   +   
Sbjct: 543 EASQDLLGT--LRKQLSDSESERRALEEQLQRLRDKTDGAMQAHED--AQREV-QRLRSA 597

Query: 667 KEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTK 726
            E L  E   L   L   ++Q   LR   +   Q A+  L   +++ E E+    +   +
Sbjct: 598 NELLSREKSNLAHSLQVAQQQAEELRQE-REKLQAAQEELRRQRDRLEEEQEDAVQDGAR 656

Query: 727 LRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMA--- 783
           +R EL+            R++ A    E    L     Q    + EK  +   L  A   
Sbjct: 657 VRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAG 716

Query: 784 -IQQKLALTQ-RLEDLEFDHEQSRRS--KGKLGKSKIGSPKIVSSL 825
            ++ +L++T+ R E+       S+ S     L + K+   ++V+ L
Sbjct: 717 RVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQL 762



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 95/478 (19%), Positives = 189/478 (39%), Gaps = 73/478 (15%)

Query: 48   LKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKV-------------AEDGETREETL 94
            L +Q  E+EAE DS      QL++A  +S    R V              E+   R E  
Sbjct: 1535 LNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERE 1594

Query: 95   LQESASKEAYYLGKILEMQNELKQS-------RAVVTNVQAENERLTAVVQDLKENNEMV 147
             + +  + A     +   ++EL+ S       +A  T ++ +  RL  V+   +     +
Sbjct: 1595 RRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKL 1654

Query: 148  ELQRIRMKDEIREYKF------REARLLQDYTELEEENI------------TLQKLVSTL 189
            ELQR  ++ E++  +        +A+ LQD  +  +  +            T+++L   L
Sbjct: 1655 ELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGAL 1714

Query: 190  KQNQVEYEGLKHEIKRFEE----ETVLLNSQLEDAIRLKE---IAEHQLEEALETLKNER 242
             + +     L+ +++   E     +  LNS  +  + L++     EH  +   E L   R
Sbjct: 1715 AKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAAR 1774

Query: 243  EQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRT 302
            +  +  RK+ S         +   V  L+      E  + +       G L +L    R 
Sbjct: 1775 QALSEARKQSSS--------LGEQVQTLR-----GEVADLELQRVEAEGQLQQLREVLRQ 1821

Query: 303  PTLRKGESLNPVSDLFSELNI--SEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGA 360
                +  +LN V  L  E  +    +  L++ L Q+E EK      ++ S  +LE  + A
Sbjct: 1822 RQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEK----REVERSALRLEKDRVA 1877

Query: 361  LTEQHERVHR--LTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILEC 418
            L    ++V R  L  H + +R       L   L G +   +  +    +++   + +LE 
Sbjct: 1878 LRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQ-VVVLEQ 1936

Query: 419  KYRVAVTEV------IDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLE 470
             +  A  EV      ++L+ E++ L+    ++       +  +  +++  +EQV++L+
Sbjct: 1937 SHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLK 1994



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 165/881 (18%), Positives = 331/881 (37%), Gaps = 150/881 (17%)

Query: 14   KTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAF 73
            ++ +  LT EL +   ++ +AA       +E   L++Q  +L  + DS  +E E+L+   
Sbjct: 1107 RSTVNALTSELRDLRAQREEAAA---AHAQEVRRLQEQARDLGKQRDSCLREAEELRTQL 1163

Query: 74   G-----------QSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAV 122
                        +     RK+ E  E RE  + ++ A +    LG+  + +  L++S   
Sbjct: 1164 RLLEDARDGLRRELLEAQRKLRESQEGRE--VQRQEAGELRRSLGEGAKEREALRRSNEE 1221

Query: 123  VTNV--QAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENI 180
            + +   +AE+ER++     LK  NE  E Q++ + +E R    +EA  L+          
Sbjct: 1222 LRSAVKKAESERIS-----LKLANEDKE-QKLALLEEARTAVGKEAGELRT--------- 1266

Query: 181  TLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKN 240
             LQ++  +  + + E + L+ ++K  + E   L          +E+AE Q   AL     
Sbjct: 1267 GLQEVERSRLEARRELQELRRQMKMLDSENTRLG---------RELAELQGRLAL----G 1313

Query: 241  EREQKNNLRKELSQYISLNDNHISISV--DGLKFAEDGSEPNNDDKMNGHIHGPLVKLNG 298
            ER +K + R+ L     L     S+ V    L+ A+                  L +  G
Sbjct: 1314 ERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQR----------------KLQEQEG 1357

Query: 299  DYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTK 358
            ++RT   R   SL        +  +   + L+ +L     E A L   L  ++ + +  +
Sbjct: 1358 EFRTRERRLLGSLEEARGTEKQ-QLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLE 1416

Query: 359  GALTEQHERVHRLTEHVNAMRGL--------QSSKELKAELDGEKGRDSGEEAHDYEVDI 410
              L     +       +  +R          ++       + G   RD+  E       +
Sbjct: 1417 AELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE--GL 1474

Query: 411  NGLEILECK----------YRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQ 460
            N    LEC                +  +D +A   AL+E + + + +   E+ +  ++  
Sbjct: 1475 NSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALRE-FLQELRSAQRERDELRTQTS 1533

Query: 461  MYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEEL--AQL 518
              + Q+  +E     +  +   ++K + +           L+  Q EL    E +  ++ 
Sbjct: 1534 ALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSER 1593

Query: 519  YHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSS 578
                 L    T  R +     + R ++    K   +   L   +   + V    E+RT  
Sbjct: 1594 ERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVK 1653

Query: 579  EPVAKESTEASKEPS-------PTKTPTISPVITA-----PPSSPVLDTSDIRKEPMN-- 624
              + + S E   + S         +   +   + +       S     T  +  E +N  
Sbjct: 1654 LELQRRSLEGELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGA 1713

Query: 625  ---IYNLNAIIRDQIKHLQKAV-----------DRSLQLSRQRAAARELAPMIDKDKEAL 670
               +      +RD+++ L +A+           D++L L +   A      ++ +  +A 
Sbjct: 1714 LAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAA 1773

Query: 671  MEEILKLKSLLSTKREQIATLR---AVLKANKQTAEVALANLKN---KYENEKAMVTETM 724
             + + + +   S+  EQ+ TLR   A L+  +  AE  L  L+    + +  +A    T+
Sbjct: 1774 RQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTV 1833

Query: 725  TKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAI 784
             KL++E + L+E                     +L  +QR LA  E EK+ +        
Sbjct: 1834 QKLQDERRLLQE---------------------RLGSLQRALAQLEAEKREVERSALRLE 1872

Query: 785  QQKLALTQRLEDLEFD----HEQSRR---SKGKLGKSKIGS 818
            + ++AL + L+ +E +    HE + R    KG+L ++  G+
Sbjct: 1873 KDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGA 1913



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 54/260 (20%), Positives = 107/260 (41%), Gaps = 30/260 (11%)

Query: 4    EEVLQTVDHYKTEI-ERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSL 62
            ++ L   +H +  + ERL       +  + Q++  G    E+  TL+ +  +LE +    
Sbjct: 1753 QKALTACEHDRQVLQERLDAARQALSEARKQSSSLG----EQVQTLRGEVADLELQRVEA 1808

Query: 63   KQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAV 122
            + +L+QL+E   Q         ++GE      +Q+   +      ++  +Q  L Q  A 
Sbjct: 1809 EGQLQQLREVLRQR--------QEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAE 1860

Query: 123  VTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITL 182
               V+    RL      L+   + VE +++R  ++       + RL +  T  E E    
Sbjct: 1861 KREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEA 1920

Query: 183  QKLVSTLK-------------QNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEH 229
            Q+ +  L+             Q +V+ +  + E+++  E      +Q E  +  +E A  
Sbjct: 1921 QRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHR 1980

Query: 230  Q----LEEALETLKNEREQK 245
            Q    LEE + TLK + +Q+
Sbjct: 1981 QRVRGLEEQVSTLKGQLQQE 2000


>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
          Length = 1213

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 108/485 (22%), Positives = 221/485 (45%), Gaps = 69/485 (14%)

Query: 23  ELTETTHEKIQAAEYGLVVLEEKLTLKQ-QYDELEAEYDSLKQEL-------EQLKEAFG 74
           E  E T++ +Q AE  L  L +K+   +     L AE ++L++ +       E++ +   
Sbjct: 343 EELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTES 402

Query: 75  QSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLT 134
           Q   + +K+ E+    +E  L+    K    + ++ +++    +S++  T +    E+  
Sbjct: 403 QCRELRKKLQEEEHHSKELRLE--VEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEK 460

Query: 135 AVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQV 194
            + +DL    E+V       K  ++E +  E+RL +    L+++   L KL S       
Sbjct: 461 NLTKDLLNELEVV-------KSRVKELECSESRLEKAELSLKDD---LTKLKSFTVMLVD 510

Query: 195 EYEGLKHEIKRFEEETVLLNSQLE-DAIRLKEIAEHQLEEA--LETLKNEREQK-NNLRK 250
           E + +  +IK+ E +   LN   + +  ++ ++ E  +EE+  L  LK+E E+K  NL +
Sbjct: 511 ERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTR 570

Query: 251 ELSQYISL------NDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPT 304
           E  + I          + +S SVD LK   DG E    +   G                 
Sbjct: 571 ERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRS--------------- 615

Query: 305 LRKGESLN-PVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTE 363
            RKG  L  P  +   EL + EI++LK++L Q+E    ++  +L +++ + +  +     
Sbjct: 616 -RKGSELTCPEDNKIKELTL-EIERLKKRLQQLE----VVEGDLMKTEDEYDQLEQKFRT 669

Query: 364 QHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVA 423
           + ++ + L++ +         +E+K ++   K  + GE     E +      L  ++R+ 
Sbjct: 670 EQDKANFLSQQL---------EEIKHQIAKNKAIEKGEVVSQ-EAE------LRHRFRLE 713

Query: 424 VTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHM 483
             +  DLKAE++ALKEK ++ + N  D+ ++ +    +  ++    E   K  G+++ ++
Sbjct: 714 EAKSRDLKAEVQALKEKIHE-LMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNL 772

Query: 484 EKELQ 488
            KEL+
Sbjct: 773 TKELE 777



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 163/770 (21%), Positives = 293/770 (38%), Gaps = 149/770 (19%)

Query: 2   AAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDS 61
           A E+V+  +   KT+ E L         EK+      L VL     L Q+    E  Y+ 
Sbjct: 93  AREDVIHMLKTEKTKPEVLEAHYGSAEPEKV------LRVLHRDAILAQEKSIGEDVYEK 146

Query: 62  LKQELEQLKEAFGQSFSIHRK---VAEDGETREETLLQESASKEAYYLGKILEMQNELKQ 118
              EL++L+E   +++    +   +AE    R    L+    K   Y+ K  +  N L+Q
Sbjct: 147 PISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQ 206

Query: 119 SRAVVTNV-------QAENERLTAVVQDLKENNEMVELQR--IRMKDEIR---EYKFREA 166
            R  +  +       QA  E+  A   + K  +E+V+L+   + + DE +   E    ++
Sbjct: 207 ERERLKKLLEQEKAYQARKEKENAKRLN-KLRDELVKLKSFALMLVDERQMHIEQLGLQS 265

Query: 167 RLLQDYTE-LEEENITLQKLVSTLKQNQVEYEGLK----HEIKRFEEETVLLNSQLEDA- 220
           + +QD T+ L EE   L+ + S  K+++ +   L+    H+  RF +E   +N++L +  
Sbjct: 266 QKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQE 325

Query: 221 -----IRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAED 275
                +RLK +   Q  E LE      E   NL+K   +   L D         +   E 
Sbjct: 326 SHNRQLRLKLVGLTQRIEELE------ETNKNLQKAEEELQELRDK--------IAKGEC 371

Query: 276 GSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQ 335
           G+     +  N  +   ++++ G        K E +       +E    E++K  Q+   
Sbjct: 372 GNSSLMAEVEN--LRKRVLEMEG--------KDEEITK-----TESQCRELRKKLQEEEH 416

Query: 336 VEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEK 395
             +E  + +  LQ+  ++LE  + A ++      +L  H+N  +    +K+L  EL+  K
Sbjct: 417 HSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQL--HLNLEKEKNLTKDLLNELEVVK 474

Query: 396 GRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKY 455
            R               ++ LEC         + LK ++  LK      V    DE+   
Sbjct: 475 SR---------------VKELECSESRLEKAELSLKDDLTKLKSFTVMLV----DERKNM 515

Query: 456 ESKIQMYDEQVTSLEKTTK-ESG------EKMAHMEKELQKMTSIANENHSTLNTAQDEL 508
             KI+  + +V  L K  K E G      EK+    K+L K+ S   E    L   +DEL
Sbjct: 516 MEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDEL 575

Query: 509 VTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGV 568
           +                                     G LK  ++    LS       V
Sbjct: 576 I-------------------------------------GKLKSEEEKSSELS-----CSV 593

Query: 569 SSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLD-TSDIRKEPMNIYN 627
               +     E V +E T                 +T P  + + + T +I +    +  
Sbjct: 594 DLLKKRLDGIEEVEREITRGRSRKGSE--------LTCPEDNKIKELTLEIERLKKRLQQ 645

Query: 628 LNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQ 687
           L  +  D    L K  D   QL ++    ++ A  + +  E +  +I K K++   ++ +
Sbjct: 646 LEVVEGD----LMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAI---EKGE 698

Query: 688 IATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKED 737
           + +  A L+   +  E    +LK + +  K  + E M K  ++L  L+ D
Sbjct: 699 VVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNK-EDQLSQLQVD 747



 Score = 38.5 bits (88), Expect = 0.026
 Identities = 46/219 (21%), Positives = 88/219 (40%), Gaps = 36/219 (16%)

Query: 625 IYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAAREL-----APMIDKDKE------ALMEE 673
           +Y L         ++ K+ D +  L ++R   ++L     A    K+KE       L +E
Sbjct: 180 VYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDE 239

Query: 674 ILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKA 733
           ++KLKS      ++       L    Q  +     L+ + E  KA+ +++          
Sbjct: 240 LVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKS---------- 289

Query: 734 LKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQR 793
            KED      L   F  +   +  + +EM  +LA  E   + L   L       + LTQR
Sbjct: 290 -KEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKL-------VGLTQR 341

Query: 794 LEDLEFDH-------EQSRRSKGKLGKSKIGSPKIVSSL 825
           +E+LE  +       E+ +  + K+ K + G+  +++ +
Sbjct: 342 IEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEV 380



 Score = 30.8 bits (68), Expect = 5.4
 Identities = 51/230 (22%), Positives = 98/230 (42%), Gaps = 43/230 (18%)

Query: 619 RKEPMNIYNLNAIIRDQIKHLQKAV-----DRSL---QLSRQRAAARELAPMIDKDKEAL 670
           RKE  N   LN + RD++  L+        +R +   QL  Q    ++L   + +++E L
Sbjct: 224 RKEKENAKRLNKL-RDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKL 282

Query: 671 M----------EEILKLK-------SLLSTKREQIATLRAVLKANKQTAEVALANLKNKY 713
                      +++LKL+       S  S + E++    A  +++ +   + L  L  + 
Sbjct: 283 KAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRI 342

Query: 714 ENEKAMVTETMTKLRNELKALKEDAATF----SSL---------RAMFATRCDEYVTQLD 760
           E E     + + K   EL+ L++  A      SSL         R +     DE +T+ +
Sbjct: 343 E-ELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTE 401

Query: 761 EMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGK 810
              R+L     E++  +  LR+ +++   L +R+ +LE   E   +SK +
Sbjct: 402 SQCRELRKKLQEEEHHSKELRLEVEK---LQKRMSELEKLEEAFSKSKSE 448


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 167/859 (19%), Positives = 356/859 (41%), Gaps = 113/859 (13%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLK 63
            +E+ Q++   KT+ ++L +EL +T    + + +  ++ LE+ L L+ Q      E   L+
Sbjct: 467  KELEQSLLFEKTKADKLQRELEDTRVATV-SEKSRIMELEKDLALRVQ------EVAELR 519

Query: 64   QELEQLKEA--FGQSFSIHRKVAEDGETREETLL---QESASKEAYYLGKILEMQNELKQ 118
            + LE  K A     S S+ ++++   E  E T     +E  S + ++  +    Q E+K 
Sbjct: 520  RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKA 579

Query: 119  SRAVVTNVQAENERLTAVVQDL-KENNEMVELQRIRMKDEIREYKFREARLLQDYTE-LE 176
                   +  ENE L + ++   KEN++++ L + +++  I  ++     L   +++ L 
Sbjct: 580  LYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLG 639

Query: 177  EENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALE 236
             E     +L + +++ +++Y+   HEI+  + +        +D+ R     E +   A +
Sbjct: 640  TETAEFAELKTQIEKMRLDYQ---HEIENLQNQ--------QDSERAAHAKEMEALRA-K 687

Query: 237  TLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKL 296
             +K  +E++N+L    S+     D H+    D L   ++      + ++         K+
Sbjct: 688  LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKV 747

Query: 297  NGDYRTPTLRKGESLNPVSDL--FSELNISEIQKLKQQLMQVEREKAILLANLQESQTQL 354
              ++ +      E L  +  L   S    SE++KL+QQL   E++   L        ++ 
Sbjct: 748  IDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA 807

Query: 355  EHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEA----HDYEVDI 410
                  L  +  ++  L E+++ +  ++ + E + ++  EK  ++ EEA       +  +
Sbjct: 808  SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV 867

Query: 411  NGLEILECKYRVAVTEVIDLKAEIKALKEKYNKS---VENYTDEKAKYESKI----QMYD 463
            N L   E ++ +  +++  L+  +  ++ K+ +     E     K K E+ I    +M  
Sbjct: 868  NKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG 927

Query: 464  EQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQ------ 517
            +  + L K   E   K   +E ELQ   + ANEN S L  + +++   +E+  Q      
Sbjct: 928  DNSSQLTKMNDELRLKERDVE-ELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH 986

Query: 518  -------------------LYHHVC----------LCNNETPNRVMLDYYRQSRVTRSGS 548
                                 H+ C              +T +  +L   +++ +     
Sbjct: 987  EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK 1046

Query: 549  LKGP-DDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAP 607
            LKG  ++  GLL      R  +   +   ++E   +   + +KE    KT T++ +    
Sbjct: 1047 LKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKE----KTETLASLEDTK 1102

Query: 608  PSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAA-RELAPMIDKD 666
             ++  L       +  N+ N+  +  ++ K L    ++ ++  R+     ++ A    + 
Sbjct: 1103 QTNAKLQNELDTLKENNLKNVEEL--NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQ 1160

Query: 667  KEALMEEILKLKSLLSTKREQIATLRAV-----------LKANKQT------AEVALANL 709
              AL EE +KL   L   R+++ + + +           L+  K+       A+   A+L
Sbjct: 1161 LSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASL 1220

Query: 710  KNKYENEKAMVTET---MTKLRNELKALKEDAATFSSLRAMFATRCDEYV---------- 756
            +       A++TE    + KLRNE+  L+ + A+  SL ++  T   + V          
Sbjct: 1221 QKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLE 1280

Query: 757  TQLDEMQRQLAAAEDEKKT 775
             QL E +RQL+++     T
Sbjct: 1281 LQLKENKRQLSSSSGNTDT 1299



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 162/854 (18%), Positives = 331/854 (38%), Gaps = 115/854 (13%)

Query: 24   LTETTHEKIQAAEYGLVVLEEKLTLKQQY-DELEAEYDSLKQELEQLKEAFGQSFSIHRK 82
            LTET+    +    G   L+E L  KQQ+ ++L AE D  + E             + + 
Sbjct: 336  LTETSSRYARKIS-GTTALQEALKEKQQHIEQLLAERDLERAE-------------VAKA 381

Query: 83   VAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKE 142
             +  GE  +E  L      +      +LE++ ++ Q R   T V+A +     ++  L+E
Sbjct: 382  TSHVGEIEQELALARDGHDQ-----HVLELEAKMDQLR---TMVEAADREKVELLNQLEE 433

Query: 143  NNEMVELQRIRMKDEI-------REYKFREARLLQDYTELEEENITLQKLVSTLKQNQVE 195
                VE  + R+++E         + K   AR+ +    L  E     KL   L+  +V 
Sbjct: 434  EKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVA 493

Query: 196  YEGLKHEIKRFEEETVLLNSQLEDAIR-----------------LKEIAEHQLEEALETL 238
                K  I   E++  L   ++ +  R                 L+EI+   L+E LE  
Sbjct: 494  TVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISS--LQEKLEVT 551

Query: 239  KNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNG 298
            + + +++    KE   +    +      +  L  A +     N+   +   H    K N 
Sbjct: 552  RTDHQREITSLKE---HFGAREETHQKEIKALYTATEKLSKENESLKSKLEHAN--KENS 606

Query: 299  DY--------RTPTLRKGESLNPVSDLFSE---LNISEIQKLKQQLMQVEREKAILLANL 347
            D          T      +++  +   FS+      +E  +LK Q+ ++  +    + NL
Sbjct: 607  DVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENL 666

Query: 348  QESQT--QLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHD 405
            Q  Q   +  H K     + + +  + E  N++  ++S  +   +    +  D+  +  +
Sbjct: 667  QNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQE 726

Query: 406  YEVDINGLEILECKYRVAVTEVIDLKAEIKALKEK------YNKSVENYTDEKAKYESKI 459
             E+ +  LE+L+ K       + +  +++KA +EK        K+      E  K   ++
Sbjct: 727  AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQL 786

Query: 460  QMYDEQVTSLEKTTKESGEKMAHMEKELQ----KMTSIANENHSTLNTAQDELVTFSEEL 515
            +  ++Q+  LE        K + + +ELQ    K+T++  EN S ++  ++   T  +EL
Sbjct: 787  EAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNL-QENLSEVSQVKE---TLEKEL 842

Query: 516  AQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLAR-RGVSSPVET 574
              L       + E    V +    Q  V +   L   ++   +LS  L + R   + +E 
Sbjct: 843  QILKEKFAEASEEA---VSVQRSMQETVNK---LHQKEEQFNMLSSDLEKLRENLADMEA 896

Query: 575  RTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAII-- 632
            +   +   +E    +KE        I  +     S       ++R +  ++  L   +  
Sbjct: 897  KFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK 956

Query: 633  -RDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATL 691
              +    LQK+++     + Q  + +E A   +++K+ L  ++  L+  + T   Q   L
Sbjct: 957  ANENASFLQKSIEDMTVKAEQ--SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 1014

Query: 692  RAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATR 751
            +A         E A +  K K+E     + +T+    ++LK  +E+ +            
Sbjct: 1015 KA-------RYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL---------- 1057

Query: 752  CDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKL 811
                + +L+E+++Q   A+   +T    +++  Q     T+ L  LE   + + + + +L
Sbjct: 1058 ----LQELEELRKQADKAK-AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL 1112

Query: 812  GKSKIGSPKIVSSL 825
               K  + K V  L
Sbjct: 1113 DTLKENNLKNVEEL 1126


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
          Length = 1116

 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 159/849 (18%), Positives = 330/849 (38%), Gaps = 139/849 (16%)

Query: 18   ERLTKELTETTHEKI------QAAEYGLV--VLEE-KLTLKQQYDELEAEYDSLKQELEQ 68
            E    ELTE   +++      QA E  L+   LEE +L ++ Q   L A  +S+K+ LE 
Sbjct: 256  EPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEM 315

Query: 69   LKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQN-------------- 114
            L     QS  +  K  E+   R   L +  A    ++L  +LE +               
Sbjct: 316  L-----QSKGLSAKATEEDHERTRRLAE--AEMHVHHLESLLEQKEKENSMLREEMHRRF 368

Query: 115  ----ELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIR--MKDEIREYKFREARL 168
                +  +++A+ T ++ ++ +++++ + L++  E +++ +    +  E RE + ++  +
Sbjct: 369  ENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV 428

Query: 169  LQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAE 228
             + +++  +  +  ++L   L   + ++E LK +    + E      Q++  +  K+   
Sbjct: 429  YRSHSKFMKNKV--EQLKEELSSKEAQWEELKKKAAGLQAEI----GQVKQELSRKDTEL 482

Query: 229  HQLEEALETLKNEREQKNNLRKELSQYISLNDNHISI---SVDGLKFAEDGSEPNNDDKM 285
              L+  LETL N+        + L + ++  +   +I    VD L+   +  E       
Sbjct: 483  LALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETM----- 537

Query: 286  NGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISE---------IQKLKQQLMQV 336
                   L K     +     KG     + DL   L++ E         I+ L++QL   
Sbjct: 538  -------LNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDK 590

Query: 337  EREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKG 396
            E++ + L   ++  Q    +T  ALT   E +      +         + LK + D ++ 
Sbjct: 591  EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI---------ERLKEQRDRDE- 640

Query: 397  RDSGEEAHDYEVDINGLE----ILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEK 452
            R+  EE  +Y+ D+  L+    +L+         ++DLK    +L     K         
Sbjct: 641  REKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK-------- 692

Query: 453  AKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFS 512
                      D ++ +LE   ++  E+   ME +L+K    A E  ++           S
Sbjct: 693  ----------DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPE--------MS 734

Query: 513  EELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPV 572
            + +  L   +    +E+ ++   +  R   + +    +  D  + +       +  +  V
Sbjct: 735  DRIQHLEREITRYKDES-SKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV 793

Query: 573  ETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAII 632
                  E V K+ +    E +  +   ++       SS  L  S  +K+           
Sbjct: 794  ANLKHKEQVEKKKSAQMLEEARRREDNLND------SSQQLQDSLRKKD----------- 836

Query: 633  RDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLR 692
             D+I+ L++A+  S+Q++ +R            + E  +EE+L     +   ++++ +++
Sbjct: 837  -DRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELL---MAMEKVKQELESMK 892

Query: 693  AVLKANKQTAEVALANLKN-KYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATR 751
            A L + +Q+      +L N + E  K +      K    L A+ E  A  + L       
Sbjct: 893  AKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALL------- 945

Query: 752  CDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLAL-TQRLEDLEFDHEQSRRSKGK 810
              E  +   + Q ++AA + EK  L   L+   Q ++ L     ED  F    S ++  K
Sbjct: 946  --ELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHK 1003

Query: 811  LGKSKIGSP 819
                +I  P
Sbjct: 1004 PSPDQIIQP 1012



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 119/581 (20%), Positives = 241/581 (41%), Gaps = 75/581 (12%)

Query: 5    EVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDE-LEAEYDSLK 63
            +V Q +    TE+  L  +L ET   +   ++  + VL+E LT K+Q    L+ E D+L+
Sbjct: 470  QVKQELSRKDTELLALQTKL-ETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALR 528

Query: 64   QELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVV 123
              LE+ KE       +++K  +         +Q+ A ++    G+I ++++ L      V
Sbjct: 529  LRLEE-KETM-----LNKKTKQ---------IQDMAEEKGTQAGEIHDLKDMLDVKERKV 573

Query: 124  TNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQ 183
              +Q +       +++L+E     E Q   +K+ ++  +          T LEE     +
Sbjct: 574  NVLQKK-------IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKE 626

Query: 184  KLVSTLK--------QNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEAL 235
            + +  LK        + Q E +  K ++K  +E+  LL   L +    KE +   L+E  
Sbjct: 627  RTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSE----KEASLLDLKEHA 682

Query: 236  ETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDG-----SEPNNDDKMNGHIH 290
             +L +   +K++  K L   +             LK A +      + P   D++  H+ 
Sbjct: 683  SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQ-HLE 741

Query: 291  GPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISE--IQKLKQQLMQVEREKAILLANLQ 348
              + +   +           L  + ++ +E N  +  I +L++Q+    ++    +ANL+
Sbjct: 742  REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKK----VANLK 797

Query: 349  ESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGR-DSGEEAHDYE 407
              + Q+E  K A  +  E   R  +++N      SS++L+  L  +  R +  EEA    
Sbjct: 798  HKE-QVEKKKSA--QMLEEARRREDNLN-----DSSQQLQDSLRKKDDRIEELEEALRES 849

Query: 408  VDING-LEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQV 466
            V I    E++  +   A T       E+    EK  + +E+   + +  +  +   +  +
Sbjct: 850  VQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHL 909

Query: 467  TSLEKTTKESGEKMAHMEKEL------QKMTSIA-NENHSTLNTAQDELVTFSEELAQLY 519
            T+L    ++  E++  M++E       +K  +IA  E  S+    Q+E+     E  +L 
Sbjct: 910  TNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLV 969

Query: 520  HHVCLCNNETPNRVML-------DYYRQSRVTRSGSLKGPD 553
              +     +T NR+ L       D+++ S   ++     PD
Sbjct: 970  QQL---KQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPD 1007



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 138/730 (18%), Positives = 291/730 (39%), Gaps = 129/730 (17%)

Query: 2   AAEEVLQTVDHYK-TEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYD 60
           A  + LQTV   K ++I  + + L +   E       G +  EE+    +Q +   +   
Sbjct: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434

Query: 61  SLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSR 120
            +K ++EQLKE                E + E L +++A  +A    +I +++ EL +  
Sbjct: 435 FMKNKVEQLKEELSSK-----------EAQWEELKKKAAGLQA----EIGQVKQELSRKD 479

Query: 121 AVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENI 180
             +  +Q + E LT    D K++ E+++        E    K + A +LQ  TE++   +
Sbjct: 480 TELLALQTKLETLTNQFSDSKQHIEVLK--------ESLTAKEQRAAILQ--TEVDALRL 529

Query: 181 TLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKN 240
            L++  + L +          +I+   EE      ++ D   + ++ E ++    + ++N
Sbjct: 530 RLEEKETMLNKK-------TKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIEN 582

Query: 241 EREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDY 300
            +EQ  +  K++S   SL +   S+  D                                
Sbjct: 583 LQEQLRDKEKQMS---SLKERVKSLQAD-------------------------------- 607

Query: 301 RTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLAN----LQESQTQLEH 356
              T     +L  + +  +E     I++LK+Q  + EREK   + N    L++ + ++  
Sbjct: 608 ---TTNTDTALTTLEEALAEKE-RTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 663

Query: 357 TKGALTEQHERVHRLTEHVN--AMRGLQSSKELKA-ELDGEKGRDSGEEAHDYEVDINGL 413
            +G L+E+   +  L EH +  A  GL+    LK  E+  E+ ++   +           
Sbjct: 664 LQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLK----------- 712

Query: 414 EILECKYRVAVTEVIDLKA--EIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEK 471
             +E + + A    ++ +A  E+    +   + +  Y DE +K ++++    E +  +E 
Sbjct: 713 --MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVEN 770

Query: 472 TTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPN 531
              +  +K+A +E++      + ++N    N    E V   ++ AQ+             
Sbjct: 771 EKNDKDKKIAELERQ------VKDQNKKVANLKHKEQVE-KKKSAQMLEEA--------- 814

Query: 532 RVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARR-GVSSPVETRTSSEPVAKESTEASK 590
           R   D    S      SL+  DD    L   L     +++  E   + E  A+ + E   
Sbjct: 815 RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQV 874

Query: 591 EPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLS 650
           E        +   + +  +        + ++  ++ NL A   ++ KHL++ ++      
Sbjct: 875 EELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRA---ERRKHLEEVLE-----M 926

Query: 651 RQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLR----AVLKANKQTAEVAL 706
           +Q A    LA + +KD       +L+L S     +E++A L+     +++  KQ  +  +
Sbjct: 927 KQEAL---LAAISEKDANI---ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRM 980

Query: 707 ANLKNKYENE 716
             + + YE++
Sbjct: 981 KLMADNYEDD 990



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 131/658 (19%), Positives = 267/658 (40%), Gaps = 120/658 (18%)

Query: 201 HEIKRFEEETVL-LNSQLEDAIRLK-------EIAEHQLEEALETLKN----EREQKNNL 248
           H +++  + T++ L +QL++ +R         E+ E +L  ++ ++K     E +++  L
Sbjct: 141 HSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL 200

Query: 249 RKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYR-----TP 303
           RK+ +  I++      +                  + N H+   +  L  + R       
Sbjct: 201 RKDEASKITIWKEQYRVV----------------QEENQHMQMTIQALQDELRIQRDLNQ 244

Query: 304 TLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTE 363
             ++  S        +EL     Q+L  +  +  +E  +L   L+E + ++E  K  L  
Sbjct: 245 LFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNA 304

Query: 364 QHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLE-ILECKYRV 422
           + E + +L E + + +GL +      E D E+ R   E     E+ ++ LE +LE K   
Sbjct: 305 RDESIKKLLEMLQS-KGLSAK---ATEEDHERTRRLAEA----EMHVHHLESLLEQK--- 353

Query: 423 AVTEVIDLKAEIKALKEKYNKSVENYTDE-KAK-YESKIQMYDEQVTSLEKTTKESGEKM 480
                   + E   L+E+ ++  EN  D  K K  ++ I+M D +++S+E+  ++     
Sbjct: 354 --------EKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD----- 400

Query: 481 AHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQL----YHHVCLCNNETPNRVMLD 536
             +E+E+Q + S     +  L+T + E     EE+ Q+     H   + N     +  L 
Sbjct: 401 --LEEEIQMLKS-----NGALSTEERE-----EEMKQMEVYRSHSKFMKNKVEQLKEELS 448

Query: 537 YYRQSRVTRSGSLKGPDDPRGLLSPRLARR-----GVSSPVETRTSSEPVAKESTEASKE 591
                         G     G +   L+R+      + + +ET T+    +K+  E  KE
Sbjct: 449 SKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE 508

Query: 592 PSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSR 651
                       +TA      +  +++    + +     ++  + K +Q   D + +   
Sbjct: 509 S-----------LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQ---DMAEEKGT 554

Query: 652 QRAAARELAPMID---KDKEALMEEILKLKSLLSTKREQIATLRAVLKA------NKQTA 702
           Q     +L  M+D   +    L ++I  L+  L  K +Q+++L+  +K+      N  TA
Sbjct: 555 QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 614

Query: 703 ----EVALA-------NLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATR 751
               E ALA        LK + + ++    E +   + +LK LKE      SL     + 
Sbjct: 615 LTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV----SLLQGDLSE 670

Query: 752 CDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLE-DLEFDHEQSRRSK 808
            +  +  L E    LA++  +K +    L +A++QK     ++E  L+  HE +  ++
Sbjct: 671 KEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEAR 728


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 186/902 (20%), Positives = 376/902 (41%), Gaps = 124/902 (13%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLK 63
            +E L  ++  K ++E     L     EK    E     LEE  TL Q+ D+L+   +SL+
Sbjct: 883  QERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQ 942

Query: 64   QELEQLKEAFGQSFSIH-------RKVAEDGETREETL------LQESASKEAYYLGKIL 110
             E +QLK     + +++       R   E  +  +ET+      + E  S+  +      
Sbjct: 943  IERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTG 1002

Query: 111  EMQNELKQSRAVV---TNVQAEN-ERLTAVVQDLKENNEMVELQR-----IRMKDEIREY 161
            E ++E +Q    +    +++A+N + LTA V+D    NE++E QR     I+ K+E+++ 
Sbjct: 1003 ETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKD----NEIIEQQRKIFSLIQEKNELQQM 1058

Query: 162  K----FREARLLQDYTELEEENITLQKLVSTL-----KQNQVEYEGLKHEIKRFEEETVL 212
                   + +L  D  E  E  I  Q+ +  L     KQ ++  +   H IK+  E +  
Sbjct: 1059 LESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRT 1118

Query: 213  LNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHIS-------I 265
             +   E   +LKE ++ QL+E  + L N +E+ + ++K++++  +L +   +       +
Sbjct: 1119 CDRLAEVEEKLKEKSQ-QLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHM 1177

Query: 266  SVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPT------LRKGES--LNPVSDL 317
              + L+ A+  +E   + K        L +L   + T        +R+ E+  L    +L
Sbjct: 1178 ETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEEL 1237

Query: 318  -FSELNISEIQKLKQQLMQVEREKAILLAN---LQESQTQLEHTKGALTEQHE---RVHR 370
              + +++ E Q+   +L +   EK   + N   L++S T+L+     L E+ E    V  
Sbjct: 1238 KIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKE 1297

Query: 371  LTEHVNAMRGLQSSKELKAELD--------------GEKGRDSGEEAHDYEVDINGL--- 413
            ++E    M  L+   E     D               EK ++S EE      + + L   
Sbjct: 1298 VSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTI 1357

Query: 414  -EILECKYRVAVTEVIDLKAEIKALKEKYNKS--VENYTDEKAKYESKIQMY-------- 462
             E LE K+      + +  A+I+  + K  +S  ++   +E  K  S+++ +        
Sbjct: 1358 KEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALL 1417

Query: 463  --DEQVTSLEKTTKESGEKMAHMEKE---LQKMTSIANENHSTLNTAQDELVT---FSEE 514
              + ++  L K  +ES ++M  + KE   LQ++  +       L     E+V     +EE
Sbjct: 1418 RIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEE 1477

Query: 515  LAQLYHHVCLCNNETPN--RVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPV 572
              ++ H       ET N  RV L        T    L+  +D        +  +     +
Sbjct: 1478 ELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNI 1537

Query: 573  ETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAII 632
            +  +  +    E  +  KE    K   +  +      S +L+ ++  +E      +    
Sbjct: 1538 KQISEVQEKVNE-LKQFKEHRKAKDSALQSI-----ESKMLELTNRLQESQEEIQIMIKE 1591

Query: 633  RDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLR 692
            ++++K +Q+A    LQ+ R +        ++ K KE+  +E   LK     + ++     
Sbjct: 1592 KEEMKRVQEA----LQIERDQ-LKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEI 1646

Query: 693  AVLKANKQTAEVALANLKNK--------YENEKAMVTETMTKLRNELKALKEDAATFSSL 744
              LK   +T ++ L N++ +        +EN + M   ++TK R++L++++E   T    
Sbjct: 1647 EHLKEQFETQKLNLENIETENIRLTQILHENLEEM--RSVTKERDDLRSVEE---TLKVE 1701

Query: 745  RAMFATRCDEYVTQLDEMQRQLAAA----EDEKKTLNTLLRMAIQQKLALTQRLEDLEFD 800
            R        E +T+  E Q +L       ++ ++T++ L  +  ++   ++   +DLE  
Sbjct: 1702 RDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHS 1761

Query: 801  HE 802
            ++
Sbjct: 1762 ND 1763



 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 155/783 (19%), Positives = 308/783 (39%), Gaps = 121/783 (15%)

Query: 48   LKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASK--EAYY 105
            ++ + + L A+YD+L  + EQL+    +   +  K+ E  +  E   L+    K  E   
Sbjct: 496  IESELNSLRADYDNLVLDYEQLRT---EKEEMELKLKEKNDLDEFEALERKTKKDQEMQL 552

Query: 106  LGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFRE 165
            + +I  ++N +K   A V N   ENE L++ V+ L+E  + ++    ++++ I   K   
Sbjct: 553  IHEISNLKNLVK--HAEVYNQDLENE-LSSKVELLREKEDQIK----KLQEYIDSQKLEN 605

Query: 166  ARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKE 225
             ++   Y+    E+         +KQ   + E +  + KR  E   L +  LE   ++KE
Sbjct: 606  IKMDLSYSLESIED------PKQMKQTLFDAETVALDAKR--ESAFLRSENLELKEKMKE 657

Query: 226  IAE--HQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDD 283
            +A    Q+E  ++  +++ E K  ++ +L + +    N I+                   
Sbjct: 658  LATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEIT------------------- 698

Query: 284  KMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAIL 343
            K+   I G + K         L   E    ++DL  ELN  E+++      +  RE+ IL
Sbjct: 699  KLTSLIDGKVPK-------DLLCNLELEGKITDLQKELN-KEVEE-----NEALREEVIL 745

Query: 344  LANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEA 403
            L+ L+   +++E  +  + ++ E +H +T   + +      KE + +   E   + G+  
Sbjct: 746  LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLE---EIGKTK 802

Query: 404  HDYEVDINGLEILECKYRVAVTEVIDLKAEIKAL---KEKYNKSVENYTDEKAKYESKIQ 460
             D     +  +  + +++   T  +D + + K +    E+ N+ + N + E  K++S + 
Sbjct: 803  DDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLG 862

Query: 461  MYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANE---NHSTLNTAQDELVTFSEELAQ 517
                  T L   T+E  EK   +++ L +M  +  +     STL T + E    +E+L Q
Sbjct: 863  ALK---TELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQ 919

Query: 518  LYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTS 577
                V     E  +   L   ++S       LK                 +   V     
Sbjct: 920  TLEEVKTLTQEKDD---LKQLQESLQIERDQLKS---------------DIHDTVNMNID 961

Query: 578  SEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIK 637
            ++   + + E+ K+   T     S +            S+     +++       +D+ +
Sbjct: 962  TQEQLRNALESLKQHQETINTLKSKI------------SEEVSRNLHMEENTGETKDEFQ 1009

Query: 638  HLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKA 697
                 +D+   L    A   +      KD E ++E+  K+ SL+  K E    L +V+  
Sbjct: 1010 QKMVGIDKKQDL---EAKNTQTLTADVKDNE-IIEQQRKIFSLIQEKNELQQMLESVIAE 1065

Query: 698  NKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSS----LRAMFATRCD 753
             +Q       N++   EN+     E +  L +ELK  +E  A   +         +  CD
Sbjct: 1066 KEQLKTDLKENIEMTIENQ-----EELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCD 1120

Query: 754  ----------EYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQ 803
                      E   QL E Q+QL   ++E   +   +      K  L  +  +L  +H +
Sbjct: 1121 RLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNK--ELTLEHME 1178

Query: 804  SRR 806
            + R
Sbjct: 1179 TER 1181



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 152/848 (17%), Positives = 347/848 (40%), Gaps = 140/848 (16%)

Query: 5    EVLQTVDHYKTE---IERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDS 61
            E+ Q  +H K +   ++ +  ++ E T+   ++ E   ++++EK  +K+  + L+ E D 
Sbjct: 1549 ELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQ 1608

Query: 62   LKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRA 121
            LK+  ++          I  K+ E  E   + L   + ++    + +I  ++ + +  + 
Sbjct: 1609 LKENTKE----------IVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKL 1658

Query: 122  VVTNVQAENERLTAVV--------------QDLKENNEMVELQRIRMKDEIREYKFREAR 167
             + N++ EN RLT ++               DL+   E ++++R ++K+ +RE   R+  
Sbjct: 1659 NLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLE 1718

Query: 168  LLQD----YTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRL 223
              ++    +  L+E   T+ KL   + +   E   ++ +++   +     + ++++ +R+
Sbjct: 1719 KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRI 1778

Query: 224  KEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAED-----GSE 278
              +   + +E ++ L+    +K +    + + +  ++  +   +  LK  E        +
Sbjct: 1779 AHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKD 1838

Query: 279  PNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSEL-NISEIQKLKQQLMQVE 337
             N   K    +     ++     T +  + E+LN    L   L  +  + K +  L +VE
Sbjct: 1839 VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVE 1898

Query: 338  R----EKAILLANLQES-------QTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKE 386
                 E+  L  +LQE+       Q +L+  +    E  E V +L E ++  + +Q S +
Sbjct: 1899 ETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISE-KTIQIS-D 1956

Query: 387  LKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVT-EVIDLKAEIKALKEKYNKSV 445
            ++ +LD  K +D  ++    E+    L++L  K  V ++ + I+   ++K   E  N S+
Sbjct: 1957 IQKDLD--KSKDELQKKIQ-ELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSM 2013

Query: 446  ENYTDEKAKYESKIQMYDEQVTSLEKTTKESG--EKMAHMEKE-----LQKMTSIANENH 498
            ++   +  +   K+    E++  + K   E    ++   ME++     L++M +   +NH
Sbjct: 2014 QSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNH 2073

Query: 499  ST-------------LNTAQDELVTFSEELAQLY-----HHVCLCNNETPNRVMLDYYRQ 540
                           L  +  E  +  +EL + Y     H+ CL      NR+ LD  ++
Sbjct: 2074 QVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECL------NRLSLDLEKE 2127

Query: 541  SRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTI 600
                +  S++       L  P L  + +    +  T+++  + E     K+        +
Sbjct: 2128 IEFQKELSMR---VKANLSLPYLQTKHIE---KLFTANQRCSMEFHRIMKK--------L 2173

Query: 601  SPVITAPPSSPVLDTSDIRKEPMNIYNLNAI--------IRDQIKHLQKAVDRSLQLSRQ 652
              V+     S V    + + E +N + ++ I        +  +I+HLQ+  D        
Sbjct: 2174 KYVL-----SYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCD-------- 2220

Query: 653  RAAARELAPM-IDKDKEALMEEILK-------------LKSLLSTKREQIATLRAVLKAN 698
               +REL  + ++++ +  +EEILK              + +LS ++E    L   L   
Sbjct: 2221 -VPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWL--- 2276

Query: 699  KQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQ 758
                   +  LKN  + E   + +      N + A+  ++  F    A  +   ++ +  
Sbjct: 2277 --NTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKS 2334

Query: 759  LDEMQRQL 766
            L E   +L
Sbjct: 2335 LKEKNEKL 2342



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 98/532 (18%), Positives = 238/532 (44%), Gaps = 55/532 (10%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLK 63
            +E +  ++H K + E     L     E I+  +     LEE  ++ ++ D+L +  ++LK
Sbjct: 1640 QEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLK 1699

Query: 64   QELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVV 123
             E +QLKE      ++   +  D E +EE  +     K         E Q  + + R +V
Sbjct: 1700 VERDQLKE------NLRETITRDLEKQEELKIVHMHLK---------EHQETIDKLRGIV 1744

Query: 124  TNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQ 183
            +    +   ++ + +DL+ +N+ ++ Q +++++E+R            +  L+E+  T+ 
Sbjct: 1745 SE---KTNEISNMQKDLEHSNDALKAQDLKIQEELR----------IAHMHLKEQQETID 1791

Query: 184  KLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQL----EEALETLK 239
            KL   + +   +   ++ +++         N++L++ I+  +  EHQL    ++  ET K
Sbjct: 1792 KLRGIVSEKTDKLSNMQKDLEN-------SNAKLQEKIQELKANEHQLITLKKDVNETQK 1844

Query: 240  NEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIH--GPLVKLN 297
               E +   ++   Q ++L+   I       K  E+  E  +  K   ++      +KL 
Sbjct: 1845 KVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLE 1904

Query: 298  GDYRTPTLRKGESLN-------PVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQES 350
             D    +L++ ++ +         + + S+ +   + KL++++ +   + + +  +L +S
Sbjct: 1905 RDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKS 1964

Query: 351  QTQLEHTKGALTEQHERVHRLTEHVN-AMRGLQSSKELKAELDGEKGRDSGEEAHDYEVD 409
            + +L+     L ++  ++ R+ E VN + + +   ++LK + + +          ++++ 
Sbjct: 1965 KDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLT 2024

Query: 410  INGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQ--VT 467
                E LE + R+   E  +L+   ++LK + ++ +    +  A+     Q+  E+  ++
Sbjct: 2025 KKLHESLE-EIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLS 2083

Query: 468  SLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDEL---VTFSEELA 516
              ++   ES  +     KEL K  S  ++++  LN    +L   + F +EL+
Sbjct: 2084 DGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELS 2135



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 164/878 (18%), Positives = 352/878 (40%), Gaps = 118/878 (13%)

Query: 18   ERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELE----QLKEAF 73
            +++ + L +     + A      +  E L LK++  EL   Y  ++ +++    QL+   
Sbjct: 621  KQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKK 680

Query: 74   GQSFSIHRKV--AEDGETREETLLQESASKEAY----YLGKILEMQNELKQS-------- 119
                 + +++  A +  T+  +L+     K+        GKI ++Q EL +         
Sbjct: 681  KMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALR 740

Query: 120  -----RAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTE 174
                  + + ++ +E ERL   +QD  E   ++  ++ ++  E+   + R   LL++  +
Sbjct: 741  EEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGK 800

Query: 175  LEEENITL----------------------QKLVSTLKQNQ---VEYEGLKHEIKRFEEE 209
             +++  T                       QK    L++N+    E   L  E ++F+  
Sbjct: 801  TKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSS 860

Query: 210  TVLLNSQL-----EDAIRLKEIAE-----HQLEEALE----TLKNEREQKNNLRKELSQ- 254
               L ++L     E   + +E+ E      QL+E LE    TL+    +K  + ++L Q 
Sbjct: 861  LGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQT 920

Query: 255  -----YISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHI------HGPLVKLNGDYRTP 303
                  ++   + +    + L+   D  + +  D +N +I         L  L     T 
Sbjct: 921  LEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETI 980

Query: 304  TLRKGESLNPVS-DLFSELNISEIQ-KLKQQLMQVEREKAILLANLQESQTQLEHTKGAL 361
               K +    VS +L  E N  E + + +Q+++ +++++ +   N Q     ++  +  +
Sbjct: 981  NTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNE--I 1038

Query: 362  TEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYR 421
             EQ  ++  L +  N ++ +  S      +  EK +   +   + E+ I   E L     
Sbjct: 1039 IEQQRKIFSLIQEKNELQQMLES------VIAEKEQLKTDLKENIEMTIENQEELRL-LG 1091

Query: 422  VAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMA 481
              + +  ++ A+ K    K    +    D  A+ E K++   +Q+   ++      E+M+
Sbjct: 1092 DELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMS 1151

Query: 482  HMEKELQKMTSIANE---NHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYY 538
             M+K++ ++ ++ NE      TL   + E +  +++L + Y  V    + T  R +L   
Sbjct: 1152 EMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEV---KSITKERKVLKEL 1208

Query: 539  RQSRVTRSGSLKG---PDDPRGLLSP---RLARRGVSSPVET-----RTSSEPVAKESTE 587
            ++S  T    L+G     +  GL +    ++A   +    ET     R+ SE  A+    
Sbjct: 1209 QKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINT 1268

Query: 588  ASKEPSPTKTPTISPVI-----TAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKA 642
               E S TK     PV+       P    V +T +   E + +    +  +D     +  
Sbjct: 1269 QDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNE-LELLTEQSTTKDSTTLARIE 1327

Query: 643  VDRSLQLSRQRAAARELAPMIDKDKEAL--MEEILKLKSLLSTKREQIATLRAVLKANKQ 700
            ++R L+L+ +   ++E    + K+++ L  ++E L++K      +E I    A ++ ++ 
Sbjct: 1328 MER-LRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKH--DQLKEHIRETLAKIQESQS 1384

Query: 701  TAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDE---YVT 757
              E +L N+K K +NE   +   M + + +  AL         L        DE      
Sbjct: 1385 KQEQSL-NMKEK-DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAK 1442

Query: 758  QLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLE 795
            + D++QR     + E   L   ++  + + L   + L+
Sbjct: 1443 EKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELK 1480



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 96/530 (18%), Positives = 215/530 (40%), Gaps = 78/530 (14%)

Query: 22   KELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSL-KQELEQLKEAFGQSFSIH 80
            KE  +   EKI  +E  + + + +  L +  DEL+ +   L K+EL+ L+     + S H
Sbjct: 1937 KETVDKLREKI--SEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMS-H 1993

Query: 81   RKVAEDGETREE----TLLQESASKEAYYLGKILE--------MQNELKQSRAVVTNVQA 128
            +K+ E  + +++     L  +S   + + L K L         +  E  + R +  +++ 
Sbjct: 1994 KKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKM 2053

Query: 129  ENERLTAVVQDL----KENNEMVELQRI------RMKDEIREYKFREARLLQDYTELEEE 178
            E ++  A ++++    ++N+++   +R+       + + +RE   R   LL+ Y+E+++ 
Sbjct: 2054 ERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDH 2113

Query: 179  NITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETL 238
               L +L   L++     + L   +K       L    +E      +    +    ++ L
Sbjct: 2114 YECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKL 2173

Query: 239  KNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNG 298
            K        +++E          H SI+   + F ++  +         H+       + 
Sbjct: 2174 KYVLSYVTKIKEE---------QHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSR 2224

Query: 299  DYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQE---SQTQLE 355
            + R   L +   L+ + ++  + + SE   +K +  QV   +  +   L+E   ++  +E
Sbjct: 2225 ELRDLKLNQNMDLH-IEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIE 2283

Query: 356  HTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEI 415
              K  + ++++R+ ++    N          + A ++         E+ ++E        
Sbjct: 2284 KLKNGIQKENDRICQVNNFFN--------NRIIAIMN---------ESTEFE-------- 2318

Query: 416  LECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQM-------YDEQVTS 468
                   + T   + + ++K+LKEK  K  +NY   K    S  Q+        +  VTS
Sbjct: 2319 -----ERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTS 2373

Query: 469  LEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQL 518
              + T+ + EK+  +E  L +    A    S +   Q EL   ++ +A+L
Sbjct: 2374 --RATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKL 2421



 Score = 38.1 bits (87), Expect = 0.034
 Identities = 61/290 (21%), Positives = 117/290 (40%), Gaps = 52/290 (17%)

Query: 19   RLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELE---QLKEAFGQ 75
            R+   + E+T  + ++A       ++  +LK++ ++L   Y +LK  L    Q+      
Sbjct: 2306 RIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQD 2365

Query: 76   SFSIHRKVAEDGETRE-----ETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAEN 130
            + + H        T E     E  L E+     +   KI++MQ EL+ +  ++  +QA+ 
Sbjct: 2366 NKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKV 2425

Query: 131  ERLTAVVQDLKEN----NEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLV 186
                  ++  KE      + V L     K+EI + K +  ++  +  +  +E    +K +
Sbjct: 2426 HESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKE---FEKEI 2482

Query: 187  STLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQ---------------- 230
            S  K   VEY+    E+ R   E +  + Q +D   + E  + Q                
Sbjct: 2483 SATKAT-VEYQ---KEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQ 2538

Query: 231  -------------LEEALETLKNEREQKNNLRKELSQYISLNDNHISISV 267
                         LE+ +  LK + EQ   L K+ ++ +S N+ H+S  V
Sbjct: 2539 NTKALILKSEHIRLEKEISKLKQQNEQ---LIKQKNELLS-NNQHLSNEV 2584



 Score = 34.3 bits (77), Expect = 0.49
 Identities = 20/65 (30%), Positives = 36/65 (55%)

Query: 38   GLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQE 97
            G+V   + L LK ++  LE E   LKQ+ EQL +   +  S ++ ++ + +T +E  L+ 
Sbjct: 2535 GIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKR 2594

Query: 98   SASKE 102
             A K+
Sbjct: 2595 EAHKQ 2599



 Score = 33.9 bits (76), Expect = 0.64
 Identities = 83/394 (21%), Positives = 151/394 (38%), Gaps = 39/394 (9%)

Query: 440 KYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKE-SGEKMAH-MEKE----------- 486
           KY K+   Y +E +  E+ ++ Y +++  L+K  +E S E  A  MEK+           
Sbjct: 327 KYMKNTP-YVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDL 385

Query: 487 LQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRS 546
           LQK+ +   EN + +      L    E  A+    V  C  +       +Y  Q  +  +
Sbjct: 386 LQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTN 445

Query: 547 GSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITA 606
            + K       LL          S V + T       E   A+K  +     +    + A
Sbjct: 446 ITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRA 505

Query: 607 PPSSPVLDTSDIR--KEPMNIYNLNAIIRDQIKHLQKAV--DRSLQLSRQRAAARELAPM 662
              + VLD   +R  KE M +        D+ + L++    D+ +QL  + +  + L   
Sbjct: 506 DYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKH 565

Query: 663 IDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANK-QTAEVALANLKNKYENEKAMV- 720
            +   + L  E+     LL  K +QI  L+  + + K +  ++ L+      E+ K M  
Sbjct: 566 AEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQ 625

Query: 721 ----TETMTK--------LRNELKALKEDAATFSSLRAMFATRCDEYVTQLD-------E 761
                ET+          LR+E   LKE     ++           Y +QL+       +
Sbjct: 626 TLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVD 685

Query: 762 MQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLE 795
           ++++L +A +E   L +L+   + + L     LE
Sbjct: 686 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLELE 719



 Score = 31.2 bits (69), Expect = 4.2
 Identities = 47/234 (20%), Positives = 99/234 (42%), Gaps = 54/234 (23%)

Query: 20   LTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSI 79
            +T   T+ T EKI+  E  L   +E    K      E++   +++ELE   +   +   +
Sbjct: 2371 VTSRATQLTTEKIRELENSLHEAKESAMHK------ESKIIKMQKELEVTNDIIAK---L 2421

Query: 80   HRKVAEDGETREET-----LLQESASKEAY-YLGKILEMQNEL-KQSRAVVTNVQAENER 132
              KV E  +  E+T     +LQ+  +  A  Y  +I +++ +L K     + N +   + 
Sbjct: 2422 QAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKE 2481

Query: 133  LTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTE------------------ 174
            ++A    ++   E++ L R  ++   R  + ++  ++ ++T+                  
Sbjct: 2482 ISATKATVEYQKEVIRLLRENLR---RSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQ 2538

Query: 175  ------LEEENITLQKLVSTLKQNQVEY-----------EGLKHEIKRFEEETV 211
                  L+ E+I L+K +S LKQ   +            + L +E+K ++E T+
Sbjct: 2539 NTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTL 2592


>gi|9910266 kinesin family member 15 [Homo sapiens]
          Length = 1388

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 169/816 (20%), Positives = 346/816 (42%), Gaps = 86/816 (10%)

Query: 25   TETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ---ELEQLKEAFGQSFSIHR 81
            TE  + K +  E+      ++LT K+Q  ELE+E  SL++    LE L EA        +
Sbjct: 593  TELNNSKQEYEEF------KELTRKRQL-ELESELQSLQKANLNLENLLEA--TKACKRQ 643

Query: 82   KVAEDGETREETLLQESASKEAYYLGK--ILEMQNELKQSRAVVTNVQA--ENERLTAVV 137
            +V++  +   ETL   +   +AY L    + ++  E+    ++ T   +  +N+ L   V
Sbjct: 644  EVSQLNKIHAETLKIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPV 703

Query: 138  ---------QDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVST 188
                     + + E    V+ Q   ++ ++ E + +  +L Q   +LE  +  +Q+L S+
Sbjct: 704  PPEMNEQAFEAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSS 763

Query: 189  LK----QNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQ 244
             +    + Q E     + +++  +ET   N  L+  +    +  H  ++ L ++K E   
Sbjct: 764  ERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVKLEYSS 823

Query: 245  -KNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIH-GPLVKLNGDYRT 302
             K N  KE ++ +S    H+ + +D L+   +    +     + + +   ++K   D  +
Sbjct: 824  FKTNQEKEFNK-LSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEIDQLS 882

Query: 303  PTLR--KGESLNPVSDLFSELNISEIQKLKQQLMQVEREK------AILLANLQESQTQL 354
              L+  K E+    SDL + + + E +K +   + ++ E+        +L  L+  + + 
Sbjct: 883  RNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEK 942

Query: 355  EHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEA-HDYEVDINGL 413
            +       +Q  +V +L E + A   + SS E        K RDS ++   D    I  L
Sbjct: 943  QKETAKCEQQMAKVQKLEESLLATEKVISSLE--------KSRDSDKKVVADLMNQIQEL 994

Query: 414  EILECKYRVAVTEVID-LKAEIKALKEKYNKSVENYTDEKAKYESK-IQMYDEQVTSLEK 471
                C+     TE ID LK E+K +  KYN ++ +  + +   + + + + D + T   +
Sbjct: 995  RTSVCEK----TETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLR 1050

Query: 472  TTKESGEK------MAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLC 525
               E  E+      +AH  ++L  +T  + ++   L +AQ+EL T  E L Q   H    
Sbjct: 1051 ILSEDIERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEEL-TKKEALIQELQHKLNQ 1109

Query: 526  NNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKES 585
              E   +   +Y  + R          +DP+   +P   +  ++  +ET+   E     +
Sbjct: 1110 KKEEVEQKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQ-EQEIEDGRA 1168

Query: 586  TEASKEPSPTKTPTISPVITAP---PSSPVLDTSDIRKEPMNIYNLNAIIR---DQIKHL 639
            ++ S E   TK      V  A        + +  ++R E   +   N +++   D IK  
Sbjct: 1169 SKTSLEHLVTKLNEDREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQ 1228

Query: 640  QKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLL-----STKREQIATLRAV 694
            ++  D++   ++Q    +E +      K  ++EE+LK+K+ L     +   +++  LR  
Sbjct: 1229 KENSDQNHPDNQQLKNEQEESIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMT 1288

Query: 695  LKANK---------QTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLR 745
             +  +         Q  E   + L+  YE E+   ++ M  LR +++ L E+       +
Sbjct: 1289 DEVERTQTLESKAFQEKEQLRSKLEEMYE-ERERTSQEMEMLRKQVECLAEENGKLVGHQ 1347

Query: 746  AMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLR 781
             +   +  +YV +L +   +LA   ++ +  N  L+
Sbjct: 1348 NLH--QKIQYVVRLKKENVRLAEETEKLRAENVFLK 1381



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 183/930 (19%), Positives = 372/930 (40%), Gaps = 143/930 (15%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQY--------DEL 55
            E+    V   + E++RL ++L E      Q      +  ++K T   +Y         + 
Sbjct: 371  EDTQGNVSQLQAEVKRLKEQLAELASG--QTPPESFLTRDKKKTNYMEYFQEAMLFFKKS 428

Query: 56   EAEYDSLKQELEQL------KEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKI 109
            E E  SL +++ QL      KE F QS  +  K  ED   R E L +ES        G +
Sbjct: 429  EQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRG------GFL 482

Query: 110  LEMQNEL-KQSRAVVTNVQAENERLTAVVQDLKENNEM-VELQRIRMKDEIREYKFREAR 167
             E Q+ L  + R  +  ++ + E    V +   EN+ +  E +R+R+ + ++  +  +A+
Sbjct: 483  PEEQDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKRAQEMDAQ 542

Query: 168  LL--------------------QDYTELEEENITL----QKLVSTLKQNQVEYEGLKHEI 203
             +                    Q ++   ++   L    +KL + L Q Q E    K E 
Sbjct: 543  TIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTELNNSKQEY 602

Query: 204  KRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHI 263
            + F+E T     +LE  ++  + A   LE  LE  K  +      R+E+SQ   ++   +
Sbjct: 603  EEFKELTRKRQLELESELQSLQKANLNLENLLEATKACK------RQEVSQLNKIHAETL 656

Query: 264  SISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLN-PVSDLFSELN 322
             I     K  +  S P           G L   N      ++   + LN PV     E+N
Sbjct: 657  KIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNS-----SILDNDILNEPVP---PEMN 708

Query: 323  ISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQ 382
                + + ++L  V+ + + L A L E     E  K    +QH  V +L  H   M+ L 
Sbjct: 709  EQAFEAISEELRTVQEQMSALQAKLDE-----EEHKNLKLQQH--VDKLEHHSTQMQELF 761

Query: 383  SS---------KELKAELDG-EKGRDSGEEAHDY-EVDINGLEILECKYRVAVTEVIDLK 431
            SS         +EL ++L+  EK     +  +D+ + +++ L ++      A  E+  +K
Sbjct: 762  SSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVV---LHSADKELSSVK 818

Query: 432  AEIKALK----EKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEK-- 485
             E  + K    +++NK  E +   + + ++ +++ +E++   +   ++S + +  + K  
Sbjct: 819  LEYSSFKTNQEKEFNKLSERHMHVQLQLDN-LRLENEKLLESKACLQDSYDNLQEIMKFE 877

Query: 486  --ELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLC------NNETPNRVMLDY 537
              +L +      + + TL +  + L+   E   +  + + L       N+      +L+ 
Sbjct: 878  IDQLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEA 937

Query: 538  YRQSRVTRSGSLKGPDDPRGLLSPRL--ARRGVSSPVETRTSSEPVAKESTEASKEPSPT 595
             RQ +   +   +        L   L    + +SS  ++R S + V  +     +E   +
Sbjct: 938  VRQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTS 997

Query: 596  ---KTPTISPV------ITAPPSSPVLDTSD----IRKEPMNIYNLNAIIRDQIKHLQKA 642
               KT TI  +      I    +S ++D  +    I+K+ ++I +L   +R  ++ L + 
Sbjct: 998  VCEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLR--LRILSED 1055

Query: 643  VDRSLQLSRQRAAARELAPMIDKDK------EALMEEILKLKSLLSTKREQIATLRAVLK 696
            ++R +       A  +L  + +  K      ++  EE+ K ++L+   + ++   +  ++
Sbjct: 1056 IERDMLCEDLAHATEQLNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVE 1115

Query: 697  ANKQTAEVALANLKNKYEN--EKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDE 754
              K      +  L++  ++  E     +T    +  L  L E             T  + 
Sbjct: 1116 QKKNEYNFKMRQLEHVMDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEH 1175

Query: 755  YVTQLDEMQRQLAAAE--------DEKKTLNTLLRMAIQQKLALTQRLEDLEF------- 799
             VT+L+E  R++  AE         E + L    +  I++   L  +L+D++        
Sbjct: 1176 LVTKLNE-DREVKNAEILRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIKRQKENSDQ 1234

Query: 800  ---DHEQSRRSKGKLGKSKIGSPKIVSSLL 826
               D++Q +  + +  K ++   KIV  +L
Sbjct: 1235 NHPDNQQLKNEQEESIKERLAKSKIVEEML 1264


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 170/808 (21%), Positives = 316/808 (39%), Gaps = 128/808 (15%)

Query: 54   ELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQ 113
            E E E  ++K+E  ++KE             E  E R + L ++  S        +L+ +
Sbjct: 846  ETEKEMATMKEEFGRIKETL-----------EKSEARRKELEEKMVS--------LLQEK 886

Query: 114  NELKQSRAVVTNVQAENERLTAVVQ---DLKENNEMVELQRIRMKDEIREYKFREARLLQ 170
            N+L+        VQAE + L    +    L +N   +E +   M + + + +   A L  
Sbjct: 887  NDLQ------LQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTA 940

Query: 171  DYTELEEENITLQKLVSTLKQNQVEYEGLKH----EIKRFEEETVLLNSQLEDAIRLKEI 226
               +LE+E   L+K +  L+    + E  KH    ++K   EE   L+  +    + K+ 
Sbjct: 941  KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKA 1000

Query: 227  AEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMN 286
             +   ++AL+ L+ E ++ N+L K   +        +   VD L+          + K+ 
Sbjct: 1001 LQEAHQQALDDLQVEEDKVNSLSKSKVK--------LEQQVDDLE-----GSLEQEKKVR 1047

Query: 287  GHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILL-- 344
              +     KL GD +       +  N    L  +L   E   + QQ  ++E E+ + L  
Sbjct: 1048 MDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFD-INQQNSKIEDEQVLALQL 1106

Query: 345  --------ANLQESQTQLEHTKGA----------LTEQHERVHRLTEHVNAMRGLQSSKE 386
                    A ++E + +LE  + A          L+ + E +    E       +Q    
Sbjct: 1107 QKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMN 1166

Query: 387  LKAELDGEKGRDSGEEAH-DYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSV 445
             K E + +K R   EEA   +E        L  K+  +V E+ +    ++ +K+K     
Sbjct: 1167 KKREAEFQKMRRDLEEATLQHEAT---AAALRKKHADSVAELGEQIDNLQRVKQKL---- 1219

Query: 446  ENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQ 505
                 EK K E K+++ D+  +++E+  K      A++EK  + +   ANE    L  AQ
Sbjct: 1220 -----EKEKSEFKLEL-DDVTSNMEQIIKAK----ANLEKVSRTLEDQANEYRVKLEEAQ 1269

Query: 506  DELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTR---SGSLKGPDDPRGLLSPR 562
              L  F+ + A+L       N E   ++       S++TR   S + +  D  R L    
Sbjct: 1270 RSLNDFTTQRAKLQTE----NGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEG 1325

Query: 563  LARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEP 622
             A+  ++  +++      + +E  E   E        +S   +        + +  R + 
Sbjct: 1326 KAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS--------EVAQWRTK- 1376

Query: 623  MNIYNLNAIIR-DQIKHLQKAVDRSLQLSRQRA-AARELAPMIDKDKEALMEEILKLKSL 680
               Y  +AI R ++++  +K + + LQ + +   A       ++K K  L  EI  L  +
Sbjct: 1377 ---YETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDL--M 1431

Query: 681  LSTKREQIATLRAVLKANKQTAEVALANLKNKYE----------NEKAMVTETMTKLRNE 730
            +  +R   A   A L   ++  +  LA  K KYE           E   ++  + KL+N 
Sbjct: 1432 VDVERSNAAA--AALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNA 1489

Query: 731  LKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLAL 790
             +   E   TF            +   QL E  + +   E  +K L         +KL L
Sbjct: 1490 YEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEV-------EKLEL 1542

Query: 791  TQRLEDLE--FDHEQSRRSKGKLGKSKI 816
               LE+ E   +HE+ +  + +L  ++I
Sbjct: 1543 QSALEEAEASLEHEEGKILRAQLEFNQI 1570



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 171/861 (19%), Positives = 340/861 (39%), Gaps = 163/861 (18%)

Query: 14   KTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAF 73
            K +I+ L   L +   EK  A E  +  L E++      DE+ A+   L +E + L+EA 
Sbjct: 953  KKDIDDLELTLAKVEKEK-HATENKVKNLTEEMA---GLDEIIAK---LTKEKKALQEA- 1004

Query: 74   GQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERL 133
                  H++  +D +  E+ +   S SK      ++ +++  L+Q + V  +++    +L
Sbjct: 1005 ------HQQALDDLQVEEDKVNSLSKSKVKLEQ-QVDDLEGSLEQEKKVRMDLERAKRKL 1057

Query: 134  TAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQ 193
               ++  +E+   +E  ++++++++++ +F    + Q  +++E+E +   +L   LK+NQ
Sbjct: 1058 EGDLKLTQESIMDLENDKLQLEEKLKKKEFD---INQQNSKIEDEQVLALQLQKKLKENQ 1114

Query: 194  VEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEA-------LETLKNEREQKN 246
               E L+ E++        +     D  R  E    +LEEA       +E  K    +  
Sbjct: 1115 ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1174

Query: 247  NLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLR 306
             +R++L +  +   +  + +    K A+  +E          +   L K   +++     
Sbjct: 1175 KMRRDLEE--ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL---- 1228

Query: 307  KGESLNPVSDLFSELNISEIQKLKQQLMQVER-------EKAILLANLQES-------QT 352
                L+ V+      N+ +I K K  L +V R       E  + L   Q S       + 
Sbjct: 1229 ---ELDDVTS-----NMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA 1280

Query: 353  QLEHTKGALTEQHERVHRLTEHV--NAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDI 410
            +L+   G L  Q E    L   +    +   Q  ++LK +L+ E+G+     AH  +   
Sbjct: 1281 KLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLE-EEGKAKNALAHALQSAR 1339

Query: 411  NGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLE 470
            +  ++L  +Y     E  + KAE++ +  K N  V  +   + KYE+      E++    
Sbjct: 1340 HDCDLLREQYE----EETEAKAELQRVLSKANSEVAQW---RTKYETDAIQRTEEL---- 1388

Query: 471  KTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETP 530
               +E+ +K+A   ++ ++     N   S+L   +  L    E+L               
Sbjct: 1389 ---EEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDL--------------- 1430

Query: 531  NRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASK 590
               M+D      V RS +     D +     ++         E+++  E   KE+   S 
Sbjct: 1431 ---MVD------VERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLST 1481

Query: 591  EPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQ--KAVDRSLQ 648
            E                                 ++ L     + ++HL+  K  +++LQ
Sbjct: 1482 E---------------------------------LFKLKNAYEESLEHLETFKRENKNLQ 1508

Query: 649  -----LSRQRAAARELAPMIDKDKEALMEEILKLKSLL-----STKREQIATLRAVLKAN 698
                 L+ Q     +    ++K ++ L  E L+L+S L     S + E+   LRA L+ N
Sbjct: 1509 EEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFN 1568

Query: 699  KQTAEV--ALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYV 756
            +  AE+   LA    + E  K      +  L+  L A          ++       +E  
Sbjct: 1569 QIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEME 1628

Query: 757  TQLDEMQRQLAAAEDEKKTLNTLLRMA-------------IQQKLALTQR--------LE 795
             QL    R  A A+ + K+L +LL+               +++ +A+ +R        LE
Sbjct: 1629 IQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELE 1688

Query: 796  DLEFDHEQSRRSKGKLGKSKI 816
            +L    EQ+ RS+ KL + ++
Sbjct: 1689 ELRAVVEQTERSR-KLAEQEL 1708



 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 133/668 (19%), Positives = 274/668 (41%), Gaps = 68/668 (10%)

Query: 183  QKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNER 242
            +K ++T+K+   E+  +K  +++ E     L  ++   ++ K   + Q++   + L +  
Sbjct: 848  EKEMATMKE---EFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAE 904

Query: 243  EQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRT 302
            E+ + L K          N I +     K  E      ++++MN  +     KL  +   
Sbjct: 905  ERCDQLIK----------NKIQLEA---KVKEMNERLEDEEEMNAELTAKKRKLEDEC-- 949

Query: 303  PTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALT 362
                  E    + DL  EL +++++K K       +     +A L E   +L   K AL 
Sbjct: 950  -----SELKKDIDDL--ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1002

Query: 363  EQHER-VHRLTEHVNAMRGLQSSK-ELKAELDGEKGRDSGEEAHDYEVDINGLEI-LECK 419
            E H++ +  L    + +  L  SK +L+ ++D  +G  S E+     +D+   +  LE  
Sbjct: 1003 EAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEG--SLEQEKKVRMDLERAKRKLEGD 1060

Query: 420  YRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLE--KTTKESG 477
             ++    ++DL+ +   L+EK  K   +   + +K E      DEQV +L+  K  KE+ 
Sbjct: 1061 LKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIE------DEQVLALQLQKKLKENQ 1114

Query: 478  EKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDY 537
             ++  +E+EL+   +   +     +    EL   SE L +           T  ++ ++ 
Sbjct: 1115 ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE-------AGGATSVQIEMNK 1167

Query: 538  YRQSRVTRSG-SLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTK 596
             R++   +    L+         +  L ++   S  E     + + +   +  KE S  K
Sbjct: 1168 KREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1227

Query: 597  TPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAV-DRSLQLSRQRAA 655
                   +T+     +   +++ K    + +     R +++  Q+++ D + Q ++ +  
Sbjct: 1228 LELDD--VTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTE 1285

Query: 656  ARELAPMIDKDKEALMEEILKLKSLLSTKREQI-------ATLRAVLKANKQTAEVALAN 708
              ELA  ++ +KEAL+ ++ + K   + + E +          +  L    Q+A      
Sbjct: 1286 NGELARQLE-EKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDL 1344

Query: 709  LKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAA 768
            L+ +YE E    TE   +L+  L     + A +   R  + T   +   +L+E +++LA 
Sbjct: 1345 LREQYEEE----TEAKAELQRVLSKANSEVAQW---RTKYETDAIQRTEELEEAKKKLAQ 1397

Query: 769  ----AEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKIVSS 824
                AE+  + +N       + K  L   +EDL  D E+S  +   L K +    KI++ 
Sbjct: 1398 RLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAE 1457

Query: 825  LLPPYRHS 832
                Y  S
Sbjct: 1458 WKQKYEES 1465



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 108/549 (19%), Positives = 227/549 (41%), Gaps = 66/549 (12%)

Query: 5    EVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ 64
            E+ + +D+ +   ++L KE +E   E          +++ K  L++    LE + +  + 
Sbjct: 1204 ELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRV 1263

Query: 65   ELEQLKEAFGQSFSIHRKV-AEDGET-----REETLLQESASKEAYYLGKILEMQNEL-- 116
            +LE+ + +     +   K+  E+GE       +E L+ +    +  Y  ++ +++ +L  
Sbjct: 1264 KLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEE 1323

Query: 117  --KQSRAVVTNVQAENERLTAVVQDLKENNEM-VELQRIRMK--DEIREYKFR-EARLLQ 170
              K   A+   +Q+       + +  +E  E   ELQR+  K   E+ +++ + E   +Q
Sbjct: 1324 EGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQ 1383

Query: 171  DYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQ 230
               ELEE     +KL   L+  +   E +  +    E+    L +++ED +    +   +
Sbjct: 1384 RTEELEEAK---KKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLM----VDVER 1436

Query: 231  LEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIH 290
               A   L  ++   + +  E  Q                K+ E  SE  +  K    + 
Sbjct: 1437 SNAAAAALDKKQRNFDKILAEWKQ----------------KYEESQSELESSQKEARSLS 1480

Query: 291  GPLVKLNGDYRTPTLR----KGESLN---PVSDLFSEL-----NISEIQKLKQQLMQVER 338
              L KL   Y          K E+ N    +SDL  +L     N+ E++K+++QL   E 
Sbjct: 1481 TELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQL---EV 1537

Query: 339  EKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRD 398
            EK  L + L+E++  LEH +G +       +++   +      +  +  +A+ + ++  D
Sbjct: 1538 EKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVD 1597

Query: 399  SGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESK 458
            S + + D E      E+L  K ++      DL  E++      N+       +    +S 
Sbjct: 1598 SLQTSLDAETRSRN-EVLRVKKKMEG----DLN-EMEIQLSHANRMAAEAQKQVKSLQSL 1651

Query: 459  IQMYDEQVTSLEKTTKESGEKMAHMEK-------ELQKMTSIANENHSTLNTAQDELVTF 511
            ++    Q+    +   +  E +A +E+       EL+++ ++  +   +   A+ EL+  
Sbjct: 1652 LKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIET 1711

Query: 512  SEELAQLYH 520
            SE + QL H
Sbjct: 1712 SERV-QLLH 1719



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 89/402 (22%), Positives = 161/402 (40%), Gaps = 53/402 (13%)

Query: 14   KTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELE-QLKEA 72
            K EIER   +L E   E  QA      V++   T          E   +K+++E  L E 
Sbjct: 1571 KAEIER---KLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEM 1627

Query: 73   FGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTN----VQA 128
              Q    +R  AE    ++   LQ         L   +   ++LK++ A+V      +QA
Sbjct: 1628 EIQLSHANRMAAE--AQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1685

Query: 129  ENERLTAVV-----------QDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEE 177
            E E L AVV           Q+L E +E V+L   +    I + K  E+ L Q  +E+EE
Sbjct: 1686 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEE 1745

Query: 178  ENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALE- 236
                 +      K+   +   +  E+K+ ++ +  L    ++  +  +  +H+L+EA + 
Sbjct: 1746 AVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1805

Query: 237  TLKNEREQKNNLR---KELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPL 293
             LK  ++Q   L    +EL   +       + SV G++ +E   +               
Sbjct: 1806 ALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELT------------ 1853

Query: 294  VKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQ 353
                  Y+T   +K  +L  + DL  +L + +++  K+Q  + E +    L+  ++ Q +
Sbjct: 1854 ------YQTEEDKK--NLLRLQDLVDKLQL-KVKAYKRQAEEAEEQANTNLSKFRKVQHE 1904

Query: 354  LEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEK 395
            L+       E  ER       VN +R        K ++  E+
Sbjct: 1905 LD-------EAEERADIAESQVNKLRAKSRDIGAKQKMHDEE 1939



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 45/246 (18%), Positives = 109/246 (44%), Gaps = 10/246 (4%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLK 63
            EE+   V+  +   +   +EL ET+            ++ +K  ++    +L++E +   
Sbjct: 1688 EELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAV 1747

Query: 64   QELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVV 123
            QE    +E   ++ +    +AE+ +  ++T       K+      I ++Q+ L ++  + 
Sbjct: 1748 QECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME-QTIKDLQHRLDEAEQIA 1806

Query: 124  TNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQ 183
              ++   ++L  +   ++E    +E ++ R  + ++  +  E R+ +   + EE+   L 
Sbjct: 1807 --LKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLL 1864

Query: 184  KLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNERE 243
            +L   + + Q++ +  K + +  EE+    N+ L    ++    +H+L+EA E       
Sbjct: 1865 RLQDLVDKLQLKVKAYKRQAEEAEEQA---NTNLSKFRKV----QHELDEAEERADIAES 1917

Query: 244  QKNNLR 249
            Q N LR
Sbjct: 1918 QVNKLR 1923


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 150/829 (18%), Positives = 332/829 (40%), Gaps = 99/829 (11%)

Query: 16   EIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKE---- 71
            + + L  +L +   E I+  +      +E +    QYD+   +Y +L+Q+L++L E    
Sbjct: 314  KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373

Query: 72   ----AFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKI---LEMQNELKQSRAVVT 124
                A     S+ +K+ E  +  +E L ++  S +      I     +  EL+Q++ +  
Sbjct: 374  QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433

Query: 125  NVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQK 184
             +QAE ++LT+V Q L+ N E  + +  R +   +  + +E  L +   E+++EN  L+ 
Sbjct: 434  VLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLK- 492

Query: 185  LVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQ 244
              S  +Q   E   L+ E+K  ++                    +Q +   E +K +   
Sbjct: 493  --SHSEQKAREVCHLEAELKNIKQ------------------CLNQSQNFAEEMKAKNTS 532

Query: 245  KNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNND---DKMNGHIHGPLVKLNGDYR 301
            +  + ++L + I+  +N  S++++ LK A    E   D   D +    H  + +LN D  
Sbjct: 533  QETMLRDLQEKINQQEN--SLTLEKLKLAVADLEKQRDCSQDLLKKREH-HIEQLN-DKL 588

Query: 302  TPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGAL 361
            + T ++ ++L           +S ++  K++  +++ EK +      E++         L
Sbjct: 589  SKTEKESKAL-----------LSALELKKKEYEELKEEKTLFSCWKSENEK-------LL 630

Query: 362  TEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGL-EILECKY 420
            T+       L   +N +     ++++K+    E+ R    +  +  V+I  L  +L+ K 
Sbjct: 631  TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS 690

Query: 421  RVAVTE---VIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESG 477
                T+    ++L+ + +   +K+ K +EN   + ++   +++  + ++  L     +  
Sbjct: 691  VEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKD 750

Query: 478  EKMAHMEKELQKMTSIANENHSTLNTAQD---ELVTFSEELAQLYHHVCLCNNETPNRVM 534
                 +  E + +  +     ++L T +D    L+ F ++ A    H    N       M
Sbjct: 751  RCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM---HHSFANIIGEQGSM 807

Query: 535  LDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASK---- 590
                 + R+    S K       +L  R+     S   + + +S+ + K+  E  +    
Sbjct: 808  PSERSECRLEADQSPKN----SAILQNRVDSLEFSLESQKQMNSD-LQKQCEELVQIKGE 862

Query: 591  -EPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQL 649
             E +  K   +     A  S  +    +      N      ++ + +  L+   ++ LQL
Sbjct: 863  IEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQN------VVAETLSALENK-EKELQL 915

Query: 650  SRQRAAARELAPMIDKDKEALMEEILKLKSLLS-TKREQIATLRAVLKANKQTAEV---- 704
               +    +      K    L+E+ LK   LLS T   +   + +++  NK+  E     
Sbjct: 916  LNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQE 975

Query: 705  --ALANLKNKYENEKAMVTETMTKLRNEL----KALKEDAATFSSLRAMFATRCDEYVTQ 758
               L  +      EK  + +      N +    K++ E +  +   + +   RC+E    
Sbjct: 976  NGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNA 1035

Query: 759  LDEMQRQLAAAEDEKKTLNTLLR----MAIQQKLALTQRLEDLEFDHEQ 803
             +++ ++  AA+++   L  LL     +   +K  L Q  E    +H++
Sbjct: 1036 YEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQE 1084



 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 130/575 (22%), Positives = 241/575 (41%), Gaps = 115/575 (20%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLE-EKLTLKQQYDELEAEYDSL 62
            E V+   ++ K E+E L  ++ E     ++  E  LV L  EK  L +Q  E + +   L
Sbjct: 2171 ELVILDAENSKAEVETLKTQIEEMARS-LKVFELDLVTLRSEKENLTKQIQEKQGQLSEL 2229

Query: 63   KQELEQLKEAFGQSFSIHRKVAEDGETREETLL----------------QESASKEAYYL 106
             + L   K    +      ++ E+ +T  E L                 QE        L
Sbjct: 2230 DKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSL 2289

Query: 107  GKILEMQNELKQS-RAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFRE 165
               +E +++L+ S   +   ++A+ ++   V+Q LKE+    +L + R+++  RE +   
Sbjct: 2290 DPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEI-- 2347

Query: 166  ARLLQDYTELEEENI-----TLQKLVSTLKQN-----------QVEYEGLKHEIKRFEE- 208
            AR  Q++  LE EN      TL+  +  + Q+           + E E L +E+++ +E 
Sbjct: 2348 ARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQER 2407

Query: 209  --ETVLLNSQLEDAIRLKEIAEHQLEEALET------------------LKNEREQKNNL 248
              E  ++NS  E+ ++ KE  + Q++E   T                  L N++E     
Sbjct: 2408 ISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAK 2467

Query: 249  RKELSQYI---------------SLNDNHISI--SVDGL-KFAEDG-----------SEP 279
             + LS  +                  +N+I +  SV+GL +  EDG           S  
Sbjct: 2468 EQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRL 2527

Query: 280  NNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVERE 339
             N  +    +   L ++ G+++   L K ++L  + +L  EL   +IQ L+ +   ++  
Sbjct: 2528 KNQIQDQEQLVSKLSQVEGEHQ---LWKEQNLE-LRNLTVELE-QKIQVLQSKNASLQDT 2582

Query: 340  KAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRG-----LQSSKELKAELDGE 394
              +L ++ +  + +LE TK       E+V+++T     ++       Q + EL+ EL GE
Sbjct: 2583 LEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGE 2642

Query: 395  KGRDSGE---------EAHDY--EVDINGLEI---LECKYRVAVTEVIDLKAEIK----A 436
            K R +GE          + D   E+ +   E+   L+C ++  V +   ++ EI      
Sbjct: 2643 KNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLR 2702

Query: 437  LKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEK 471
            L E   K      D   +YE +IQ Y E++TS E+
Sbjct: 2703 LHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEE 2737



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 153/814 (18%), Positives = 320/814 (39%), Gaps = 133/814 (16%)

Query: 53   DELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKIL-E 111
            D+L+A+   L+ ++ +L+    Q      K  +  + +E  L  E A  E     K+L +
Sbjct: 281  DQLKAQNQELRNKINELELRL-QGHEKEMK-GQVNKFQELQLQLEKAKVELIEKEKVLNK 338

Query: 112  MQNELKQSRA----VVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYK--FRE 165
             ++EL ++ A      T   A  ++L  + +DL    +  E  R  ++ +I+E +  F+E
Sbjct: 339  CRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQE 398

Query: 166  --ARLLQDYTELEEENITLQ-KLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLED--- 219
              +R  + +  L++E I ++ +L   L+Q +  +  L+ E+ +       L + LE+   
Sbjct: 399  ELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQ 458

Query: 220  -------AIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLK- 271
                   A +  +I E++L  ++E +K E    NNL K  S+  +    H+   +  +K 
Sbjct: 459  KLCRAEQAFQASQIKENELRRSMEEMKKE----NNLLKSHSEQKAREVCHLEAELKNIKQ 514

Query: 272  -------FAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNIS 324
                   FAE+    N   +    +     K+N    + TL K +    V+DL  + + S
Sbjct: 515  CLNQSQNFAEEMKAKNTSQETM--LRDLQEKINQQENSLTLEKLKLA--VADLEKQRDCS 570

Query: 325  E---------IQKLKQQLMQVEREKAILLANLQESQTQLEHTKGA--------------L 361
            +         I++L  +L + E+E   LL+ L+  + + E  K                L
Sbjct: 571  QDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLL 630

Query: 362  TEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLE-ILECKY 420
            T+       L   +N +     ++++K+    E+ R    +  +  V+I  L  +L+ K 
Sbjct: 631  TQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS 690

Query: 421  RVAVTEVI---DLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESG 477
                T+ +   +L+ + +   +K+ K +EN   + ++   +++  + ++  L     +  
Sbjct: 691  VEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKD 750

Query: 478  EKMAHMEKELQKMTSIANENHSTLNTAQDE---LVTFSEELAQLYHHVCLCNNETPNRVM 534
                 +  E + +  +     ++L T +D    L+ F ++ A    H    N       M
Sbjct: 751  RCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAM---HHSFANIIGEQGSM 807

Query: 535  LDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSP 594
                 + R+    S K                  S+ ++ R  S   + ES +       
Sbjct: 808  PSERSECRLEADQSPKN-----------------SAILQNRVDSLEFSLESQKQMNSDLQ 850

Query: 595  TKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRA 654
             +   +  +         ++ + ++ E M+  +  A    +I  LQ+        + Q  
Sbjct: 851  KQCEELVQI------KGEIEENLMKAEQMH-QSFVAETSQRISKLQEDTS-----AHQNV 898

Query: 655  AARELAPMIDKDKE------------ALMEEILKLKSLLSTKREQIATLRAVLKANKQTA 702
             A  L+ + +K+KE            A ++E+ K   LL    +++  L   L   K+  
Sbjct: 899  VAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEM 958

Query: 703  EVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEM 762
               ++  K + E           +L  E   LKE  A+ +  +     + + +   +DE 
Sbjct: 959  SSIISLNKREIE-----------ELTQENGTLKEINASLNQEKMNLIQKSESFANYIDER 1007

Query: 763  QRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLED 796
            ++ ++   D+ K          Q+KL L QR E+
Sbjct: 1008 EKSISELSDQYK----------QEKLILLQRCEE 1031



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 190/927 (20%), Positives = 368/927 (39%), Gaps = 169/927 (18%)

Query: 5    EVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLE-EKLTLKQQYDELEAEYDSLK 63
            E+LQT+    +++  L K+ T    EK+Q+ E     L   K  L+ Q  +L  E + L 
Sbjct: 2014 ELLQTLS---SDVSELLKDKTHL-QEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLV 2069

Query: 64   QELEQLK--------EAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLG-------- 107
            +E E L+        E    S ++   + E GE     L   S  +E + L         
Sbjct: 2070 KESESLQARLSESDYEKLNVSKALEAALVEKGEF---ALRLSSTQEEVHQLRRGIEKLRV 2126

Query: 108  -------KILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIRE 160
                   K L +  +LK+      +++ + E L   +Q  +EN E+V L     K E+  
Sbjct: 2127 RIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVET 2186

Query: 161  YKFR---EARLLQDY------TELEEENIT------------LQKLVSTLKQNQVEYEGL 199
             K +    AR L+ +         E+EN+T            L KL+S+ K    E E  
Sbjct: 2187 LKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQA 2246

Query: 200  KHEIKRFEEETV-LLNSQLEDAIRL-------KEI-------------AEHQLEEALETL 238
            + +IK   +  V +L +QL++           +EI              EHQL  ++E L
Sbjct: 2247 EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKL 2306

Query: 239  KNEREQKNNLRKELSQYISLNDNHISI---SVDGLKFAEDGSEPNND------DKMNGHI 289
            +   E     +  + Q +  +++H  +    V+ L+   + +  N +      +   G +
Sbjct: 2307 RARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEV 2366

Query: 290  HGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNI-SEIQKLKQQLMQVE----REKAILL 344
                 K+ G   T +LR G  L+ V+    + N+ +E+QK ++++ ++E      + IL 
Sbjct: 2367 ETLKAKIEG--MTQSLR-GLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQ 2423

Query: 345  ANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAH 404
               QE     E +  A+     ++  L E V A+   Q + + K     E+   S  E  
Sbjct: 2424 EKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAK-----EQNLSSQVECL 2478

Query: 405  DYEVD--INGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMY 462
            + E    + GL+  +  Y V  + V  L  E++  K+K  K  E  +  K + + + Q+ 
Sbjct: 2479 ELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLV 2538

Query: 463  DE--QVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYH 520
             +  QV    +  KE   ++ ++  EL++   +    +++L   QD L         L +
Sbjct: 2539 SKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASL---QDTLEVLQSSYKNLEN 2595

Query: 521  HVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEP 580
             + L   +          + S V +   +   +         +A++      E       
Sbjct: 2596 ELELTKMD----------KMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNR 2645

Query: 581  VAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQ 640
            +A E     +E   +K                L+ S+++K      +L+ + +DQ++   
Sbjct: 2646 LAGELQLLLEEIKSSKDQL---------KELTLENSELKK------SLDCMHKDQVEKEG 2690

Query: 641  KAVDR--SLQLSRQRAAARELAPMIDKDK-----------------EALMEEILKLKSLL 681
            K  +     QL    A  +  A ++D +K                 E L  + L++  L 
Sbjct: 2691 KVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLK 2750

Query: 682  STKREQIATLRAVLKANKQTAEVALANLKN----KYENEKA-----MVTETMTKLRNELK 732
            S+K E   +L+A  +  ++  +  + NLK     K ENE+A     ++ ++  +L  E +
Sbjct: 2751 SSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKE 2810

Query: 733  ALKEDAATFSSLR------AMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLL-----R 781
             L+++ +   + +       +  T+ DE  T++ E++  L   E++ K  +  L      
Sbjct: 2811 ILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETL---EEKTKEADEYLDKYCSL 2867

Query: 782  MAIQQKLALTQRLEDLEFDHEQSRRSK 808
            +   +KL   + + + +  H  S++SK
Sbjct: 2868 LISHEKLEKAKEMLETQVAHLCSQQSK 2894



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 161/848 (18%), Positives = 329/848 (38%), Gaps = 135/848 (15%)

Query: 6    VLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVV-LEEKLTLKQQYDELEAEYDSLKQ 64
            +L  ++    ++E L  E+ E    K+   E  L+  +E  + L++   EL+ E   L +
Sbjct: 1786 LLHVIEDRDRKVESLLNEMKELD-SKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSE 1844

Query: 65   ELE-------------QLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILE 111
            +LE             +  E       +H   +   +  +       + KE +     L+
Sbjct: 1845 KLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERF-----LD 1899

Query: 112  MQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQD 171
            ++NEL + R+   +++ E   L A   DL    E+V+ +++ ++ +    +     L ++
Sbjct: 1900 VENELSRIRSEKASIEHEALYLEA---DL----EVVQTEKLCLEKDNENKQKVIVCLEEE 1952

Query: 172  YTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQL 231
             + +  E   L+  + T+ +     + L  ++K   E+T  L S   + +   ++AE ++
Sbjct: 1953 LSVVTSERNQLRGELDTMSKKTTALDQLSEKMK---EKTQELESHQSECLHCIQVAEAEV 2009

Query: 232  EEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHG 291
            +E  E L+      + L K+ +                                  H+  
Sbjct: 2010 KEKTELLQTLSSDVSELLKDKT----------------------------------HLQE 2035

Query: 292  PLVKLNGDYRTPTLRKGESLNPVSDL--FSELNISEIQKLKQQLMQVEREKAILLANLQE 349
             L  L  D +  +L K E  N ++ L    EL + E + L+ +L + + EK  +   L+ 
Sbjct: 2036 KLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEA 2095

Query: 350  SQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVD 409
            +  +       L+   E VH+L   +  +R    + E K     EK ++   E    +  
Sbjct: 2096 ALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDK 2155

Query: 410  INGLE----ILECKYRVAVTEVIDLKAEIKALK---EKYNKSVENY-------TDEKAKY 455
            +  LE    + E    + + +  + KAE++ LK   E+  +S++ +         EK   
Sbjct: 2156 VENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENL 2215

Query: 456  ESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEEL 515
              +IQ    Q++ L+K    S  K    EKE Q    I  E+ + +   Q++L   +E +
Sbjct: 2216 TKQIQEKQGQLSELDKLL--SSFKSLLEEKE-QAEIQIKEESKTAVEMLQNQLKELNEAV 2272

Query: 516  AQL------------------YHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRG 557
            A L                       L N+    R  L+   + ++     LK  +    
Sbjct: 2273 AALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHAD 2332

Query: 558  LLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSD 617
            LL  R+        +  RT+ E  A E+  +  E    K       +T       LD   
Sbjct: 2333 LLKGRVENLERELEI-ARTNQEHAALEAENSKGEVETLKAKIEG--MTQSLRGLELDVVT 2389

Query: 618  IRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKL 677
            IR E  N+ N           LQK  +R  +L    ++   +    +++K  + E+    
Sbjct: 2390 IRSEKENLTN----------ELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTA 2439

Query: 678  KSLLSTKREQIATLRAVLKANKQTAEVALANLKNK---YENEKAMVTETMTKLRNELKAL 734
              +L T+ +++    A L  +++  +    NL ++    E EKA + + + + +N    L
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499

Query: 735  KEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRL 794
            +      SS+  +        + ++++ +++L   ++E     + L+  IQ +  L  +L
Sbjct: 2500 Q------SSVNGL--------IQEVEDGKQKLEKKDEE----ISRLKNQIQDQEQLVSKL 2541

Query: 795  EDLEFDHE 802
              +E +H+
Sbjct: 2542 SQVEGEHQ 2549



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 117/547 (21%), Positives = 229/547 (41%), Gaps = 88/547 (16%)

Query: 13   YKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQ-YDELEAEYDSLKQELEQLKE 71
            ++ EIE +  + ++ T + ++  E+ L +L  ++  K + Y +L AEY+SL+  L+    
Sbjct: 714  HQKEIENMCLKTSQLTGQ-VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDA 772

Query: 72   -------------AFGQSFSIHRKVA----EDGET---REETLLQ--ESASKEAYYLGKI 109
                         AF Q  ++H   A    E G     R E  L+  +S    A    ++
Sbjct: 773  SLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRV 832

Query: 110  LEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLL 169
              ++  L+  + + +++Q + E L  +  +++EN          MK E     F  A   
Sbjct: 833  DSLEFSLESQKQMNSDLQKQCEELVQIKGEIEEN---------LMKAEQMHQSF-VAETS 882

Query: 170  QDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLE-DAIRLKEI-- 226
            Q  ++L+E+    Q +V+               ++  E+E  LLN ++E +   ++E+  
Sbjct: 883  QRISKLQEDTSAHQNVVAETLS----------ALENKEKELQLLNDKVETEQAEIQELKK 932

Query: 227  AEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMN 286
            + H LE++L+ L+   E  +  +KE+S  ISLN   I          ++ +   N +KMN
Sbjct: 933  SNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMN 992

Query: 287  GHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQK----------LKQQLMQV 336
                  L++ +  +      + +S++ +SD + +  +  +Q+          L Q+    
Sbjct: 993  ------LIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAA 1046

Query: 337  EREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKG 396
            + + + L   L E  +  E+ K  L +  E   +  EH   +  L  ++E    L  E  
Sbjct: 1047 QEKNSKLECLLNECTSLCENRKNELEQLKEAFAK--EHQEFLTKLAFAEERNQNLMLE-- 1102

Query: 397  RDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYE 456
             ++ ++A   E+  N           + +E   LK EI  LKE+ NK  +   D      
Sbjct: 1103 LETVQQALRSEMTDN--------QNNSKSEAGGLKQEIMTLKEEQNKMQKEVND------ 1148

Query: 457  SKIQMYDEQVTSLEKTTKE----SGEKMAHMEKELQKMTSIAN-ENHSTLNTAQDELVTF 511
              +   +EQ+  + KT  E      E + +  KE +   +  N +    L   +  L ++
Sbjct: 1149 --LLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSY 1206

Query: 512  SEELAQL 518
            + +L QL
Sbjct: 1207 NAQLVQL 1213



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 155/865 (17%), Positives = 335/865 (38%), Gaps = 157/865 (18%)

Query: 50  QQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKI 109
           Q+  ELE + D LK+E +Q      + F +            E  LQ+   K        
Sbjct: 18  QKIQELEGQLDKLKKEKQQ------RQFQLDSL---------EAALQKQKQK-------- 54

Query: 110 LEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLL 169
             ++NE  +     TN++ EN+RL  + + L++  + +    +++K+   +  F+E +L 
Sbjct: 55  --VENEKTEG----TNLKRENQRLMEICESLEKTKQKIS-HELQVKES--QVNFQEGQLN 105

Query: 170 QDYTELEEENITLQKLVSTLKQNQ--------------------------------VEYE 197
               ++E+    L++  S L+++Q                                 +YE
Sbjct: 106 SGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYE 165

Query: 198 GLK-------HEIKRFEEETVLLNSQL------EDAIRLKEIAEHQLEEALETLKNER-- 242
            LK        E KR E E   L ++       +  +  ++IA HQ   ++ + + E+  
Sbjct: 166 DLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTP 225

Query: 243 ------EQKNNLRKELSQYISLNDNHISISVDGLKFAE-DGSEPNNDDKMNGHIHGPLVK 295
                  Q+  +R++ S      +  ++ S   L+  + D +    D+  + H+   L  
Sbjct: 226 SHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKA 285

Query: 296 LNGDYRTP----TLR---KGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQ 348
            N + R       LR     + +    + F EL + +++K K +L++ E+        L 
Sbjct: 286 QNQELRNKINELELRLQGHEKEMKGQVNKFQELQL-QLEKAKVELIEKEKVLNKCRDELV 344

Query: 349 ESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELD---GEKGRDSGEEAHD 405
            +  Q +      T   +++ +LTE ++  R  Q+++  +  L+    EK ++  EE   
Sbjct: 345 RTTAQYDQASTKYTALEQKLKKLTEDLSCQR--QNAESARCSLEQKIKEKEKEFQEELSR 402

Query: 406 YEVDINGLEILECKYRVAVTEVID--------LKAEIKAL---KEKYNKSVENYTDEKAK 454
            +     L+    + +  +T+ +         L+AE+  L   K++   ++E +  +  +
Sbjct: 403 QQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCR 462

Query: 455 YESKIQ----MYDEQVTSLEKTTKES----------GEKMAHMEKELQKMTSIANENHST 500
            E   Q      +E   S+E+  KE+            ++ H+E EL+ +    N++ + 
Sbjct: 463 AEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNF 522

Query: 501 LNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLS 560
               + +  +    L  L   +    N+  N + L+   + ++  +   K  D  + LL 
Sbjct: 523 AEEMKAKNTSQETMLRDLQEKI----NQQENSLTLE---KLKLAVADLEKQRDCSQDLLK 575

Query: 561 PRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRK 620
            R       +   ++T  E  A  S    K+    +      + +   S      + +  
Sbjct: 576 KREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMES 635

Query: 621 EPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSL 680
           E  N       ++ +I HL+  +      S +     E    ++ D+E L  EI  L ++
Sbjct: 636 EKEN-------LQSKINHLETCLKTQQIKSHE---YNERVRTLEMDRENLSVEIRNLHNV 685

Query: 681 LSTKREQIATLRAVLKANKQTAEVALANLKNKYEN---EKAMVTETMTKLRNELKALKED 737
           L +K  ++ T +      +Q AE +    + + EN   + + +T  +  L ++L+ L  +
Sbjct: 686 LDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNE 745

Query: 738 A-----------ATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQ 786
                       A + SLR +  ++    VT  D  +  LA   D++  ++      I +
Sbjct: 746 IMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAF--DQQPAMHHSFANIIGE 803

Query: 787 KLALTQRLEDLEFDHEQSRRSKGKL 811
           + ++     +   + +QS ++   L
Sbjct: 804 QGSMPSERSECRLEADQSPKNSAIL 828



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 113/521 (21%), Positives = 215/521 (41%), Gaps = 56/521 (10%)

Query: 14   KTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQEL--EQLKE 71
            ++E E LT EL +   E+I   E      E  L  K+Q      E  S   E+   QLKE
Sbjct: 2391 RSEKENLTNEL-QKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKE 2449

Query: 72   AFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGK--ILEMQNELKQSRAVVTNVQAE 129
               +  ++H    E  + +E+ L   S+  E   L K  +L+  +E K +  V+   Q+ 
Sbjct: 2450 LNERVAALHND-QEACKAKEQNL---SSQVECLELEKAQLLQGLDEAKNNYIVL---QSS 2502

Query: 130  NERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQ---DYTELEEENITLQKLV 186
               L   V+D K+  E  + +  R+K++I++ +   ++L Q   ++   +E+N+ L+ L 
Sbjct: 2503 VNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLT 2562

Query: 187  STLKQN------------------QVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAE 228
              L+Q                   Q  Y+ L++E++  + + +    ++      +   +
Sbjct: 2563 VELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQ 2622

Query: 229  HQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGH 288
             ++ E  +     +E+ +  +  L+  + L    I  S D LK  E   E +   K    
Sbjct: 2623 REMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLK--ELTLENSELKKSLDC 2680

Query: 289  IHGPLVKLNGDYRTPT----LRKGESLNPVSDLFSELNIS---EIQKLKQQLMQVER--- 338
            +H   V+  G  R       LR  E+      L  + N     EIQ  +++L   E    
Sbjct: 2681 MHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLS 2740

Query: 339  ----EKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGE 394
                E  +L ++ +E    L+ T   L E  +      ++VN ++      + K +L  +
Sbjct: 2741 SQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIK 2800

Query: 395  KGRDSGEEAHDYEVDINGLEILECKYRVAV---TEVIDLKAEIKALKEKYNKSVENYTDE 451
              +   EE    + +++ L+  + K +      T+V +L  EIK LKE   +  +   + 
Sbjct: 2801 SCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEY 2860

Query: 452  KAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTS 492
              KY S +  +++    LEK  +    ++AH+  +  K  S
Sbjct: 2861 LDKYCSLLISHEK----LEKAKEMLETQVAHLCSQQSKQDS 2897



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 194/949 (20%), Positives = 360/949 (37%), Gaps = 172/949 (18%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLK 63
            + + +  D YK E   L +   ET +     ++      E+   L+   +E  +  ++ K
Sbjct: 1009 KSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRK 1068

Query: 64   QELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQS---- 119
             ELEQLKEAF +            E R + L+ E  + +     ++ + QN  K      
Sbjct: 1069 NELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGL 1128

Query: 120  RAVVTNVQAENERLTAVVQDLKENNEMV--------ELQRIRMKDEIREYKFREARLLQ- 170
            +  +  ++ E  ++   V DL + NE +        E Q +  +      K RE+   Q 
Sbjct: 1129 KQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQC 1188

Query: 171  ---DYTELEEENITLQ----KLVS----------TLKQNQVEYEGLKHEIKRFE---EET 210
                  +LE + I+L     +LV            L++++ E E L+HE++      E +
Sbjct: 1189 NFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETS 1248

Query: 211  VLLNSQLEDAIRLKEI----------AEHQLEEALE-------TLKNEREQKNNLRK--E 251
             L + Q ++   LK+             H+L  +         +L+    + N L K  E
Sbjct: 1249 NLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICE 1308

Query: 252  LSQ------YISLNDNHISISVDGLKFAEDGSEPNNDDKM----NGHIHGPLVK--LNGD 299
            + Q         LND+         K AE+  +  N+ K+    +G +HG LV+    G+
Sbjct: 1309 ILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGE 1368

Query: 300  Y-RTPTLRKGESLNPV--SDLFSELNIS--EIQ----KLKQQLMQVEREKAIL------- 343
            +   P  +   SL P+  S+ +  L +S  E+Q    +L+++ + ++ E  IL       
Sbjct: 1369 FGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQM 1428

Query: 344  LANLQESQTQLEHTKGALTEQHERVHRLT-EHVNAMR-GLQ-------------SSKELK 388
             + + E QT ++  K         +     + V  M+ GL+              S  L 
Sbjct: 1429 SSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLS 1488

Query: 389  AELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSV--- 445
            +  D    R   E+  D  + ++ LE      + +V EV     + + L  K   S    
Sbjct: 1489 SLGDSSFYRALLEQTGDMSL-LSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAK 1547

Query: 446  ---------ENYTDEKAKYESKIQ----MYDEQVTSLEKTTKESGEKMAHMEKEL----- 487
                     E Y     K E K++    M ++++  LE+      +++  + K+      
Sbjct: 1548 GVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENE 1607

Query: 488  ---QKMTSIANENHSTL--NTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSR 542
               QK+TS+  E  S L     Q E ++   E+A+L     L   +  +R +L    +  
Sbjct: 1608 QWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQ----LQGLDLSSRSLLGIDTEDA 1663

Query: 543  V-------------TRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEAS 589
            +             T   + + P      +  + A++ ++  +E  T +  V K + E S
Sbjct: 1664 IQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAV-KPTGECS 1722

Query: 590  KEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAII-------RDQIKHLQKA 642
             E SP            PP       S      ++    NA++       ++ I +LQ  
Sbjct: 1723 GEQSPDTN-------YEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLR 1775

Query: 643  VDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIAT-LRAVLKANKQT 701
            V    + S +      +    D+  E+L+ E+ +L S L  +  Q+ T + A ++  K  
Sbjct: 1776 VK---ETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIV 1832

Query: 702  AEVALAN--LKNKYE------NEKAMVTETMTKLRNEL-----KALKEDAA-TFSSLRAM 747
             E+   N  L  K E       E     ET   L ++L     K+ +ED     + +   
Sbjct: 1833 GELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDS 1892

Query: 748  FATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLED 796
            +  R  +   +L  ++ + A+ E E   L   L +   +KL L +  E+
Sbjct: 1893 WKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNEN 1941



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 68/274 (24%), Positives = 123/274 (44%), Gaps = 39/274 (14%)

Query: 2    AAEEVLQTVDHYKTEIERLTKELTET-THEKIQAAEYGLVVLEEKLTLKQQYDELEAEYD 60
            A E  LQ   H   E+ + T EL E  + EK + A    ++LEE  + K Q  EL  E  
Sbjct: 2616 AKETELQREMH---EMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENS 2672

Query: 61   SLKQELEQL-KEAFGQSFSIHRKVAE------DGETREETLLQESASKEAY----YLGKI 109
             LK+ L+ + K+   +   +  ++AE      + E + + LL ++  +       Y  K+
Sbjct: 2673 ELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKL 2732

Query: 110  LEMQNELKQSRAVVTNVQAENERL-------TAVVQDLKENNEMVELQRI-RMKDEIREY 161
               +  L   +  +  +++  E L       T ++++LK+  +M  L+ + ++K E    
Sbjct: 2733 TSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKT-KMDNLKYVNQLKKENERA 2791

Query: 162  KFREARLLQDYTELEEENITLQKLVSTLKQNQ----------VEYEGLKHEIKR----FE 207
            + +   L++   +LEEE   LQK +S L+  Q           + + L  EIK      E
Sbjct: 2792 QGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLE 2851

Query: 208  EETVLLNSQLEDAIRLKEIAEHQLEEALETLKNE 241
            E+T   +  L+    L  I+  +LE+A E L+ +
Sbjct: 2852 EKTKEADEYLDKYCSLL-ISHEKLEKAKEMLETQ 2884



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 74/398 (18%), Positives = 154/398 (38%), Gaps = 49/398 (12%)

Query: 423 AVTEVIDLKAEIKALK-EKYNKSVENYTDEKA--KYESKIQMYDEQVTSLEKTTKESGEK 479
           A+ ++ +L+ ++  LK EK  +  +  + E A  K + K++    + T+L++  +   E 
Sbjct: 16  ALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEI 75

Query: 480 MAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYR 539
              +EK  QK++       S +N  + +L +  +++ +L   +  C +E      L+  +
Sbjct: 76  CESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSE------LERSQ 129

Query: 540 QSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPT 599
           Q+  +   SL   + P+ + +  L      S  +     E   KE  E  +  +  K   
Sbjct: 130 QAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVK--- 186

Query: 600 ISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAAREL 659
               + A  +S  L  + +    +  +  ++ +       Q+     L  + QR   R  
Sbjct: 187 ---ALQAKKASQTLPQATMNHRDIARHQASSSV---FSWQQEKTPSHLSSNSQRTPIR-- 238

Query: 660 APMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVA----------LANL 709
                +D  A         S  S ++E +   R+ L+  K+ A  +          L  L
Sbjct: 239 -----RDFSA---------SYFSGEQE-VTPSRSTLQIGKRDANSSFFDNSSSPHLLDQL 283

Query: 710 KNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAA 769
           K + +  +  + E   +L+   K +K     F  L+     + ++   +L E ++ L   
Sbjct: 284 KAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQ----LQLEKAKVELIEKEKVLNKC 339

Query: 770 EDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRS 807
            DE          A  +  AL Q+L+ L  D    R++
Sbjct: 340 RDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQN 377


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 160/798 (20%), Positives = 329/798 (41%), Gaps = 88/798 (11%)

Query: 36   EYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLL 95
            +  L +L+E  +L+++ +    ++   ++E+  LKE FG     H+K  +   T  E L 
Sbjct: 497  DMSLSLLQEISSLQEKLEVTRTDH---QREITSLKEHFGAREETHQKEIKALYTATEKLS 553

Query: 96   QESASKEAYYLGKILEMQNEL-----KQSRAVVTNVQAENERLTAVVQDLKENNEMVELQ 150
            +E+ S ++       E  + +     K   A+ ++ QA  E   +  + L    E  E  
Sbjct: 554  KENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL--GTETAEFA 611

Query: 151  RIRMKDEIREYKFR-EARLLQDYTELE------EENITLQKLVSTLKQNQVEYEGLKHEI 203
             ++ + E     ++ E   LQ+  + E      E      KL+  +K+ +   E ++ ++
Sbjct: 612  ELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKL 671

Query: 204  KRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHI 263
             + E++ ++   ++ED +   + AE +++E LE L+ +  ++  +    +  +   +  +
Sbjct: 672  DKAEDQHLV---EMEDTLNKLQEAEIKVKE-LEVLQAKCNEQTKVIDNFTSQLKATEEKL 727

Query: 264  SISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSEL-- 321
             + +D L+ A   SE  ++ K    +   L       +   + K    +  S +  EL  
Sbjct: 728  -LDLDALRKAS--SEGKSEMKK---LRQQLEAAEKQIKHLEIEKNAESSKASSITRELQG 781

Query: 322  ----------NISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRL 371
                      N+SE+ ++K+ L   E+E  IL     E+  +    + ++ E   ++H+ 
Sbjct: 782  RELKLTNLQENLSEVSQVKETL---EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 838

Query: 372  TEHVNAMRG-LQSSKELKAELDGE-KGRDSGEEA-----HDYEVDINGLEILECKYRVAV 424
             E  N +   L+  +E  A+++ + + +D  EE         E DI  +  +       +
Sbjct: 839  EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 898

Query: 425  TEVID----LKAEIKALKEKYNKSVENYTDEKAKYESKI----QMYDEQVTSLEKTTKES 476
            T++ D     + +++ L+ K  K+ EN +  +   E       Q   E     E+  KE 
Sbjct: 899  TKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKEL 958

Query: 477  GEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLD 536
              K++ +EK+++   +   E  +    A  E  T  EE+ Q      L           D
Sbjct: 959  ERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTE--------D 1010

Query: 537  YYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTE--ASKEPSP 594
              + +R   SG L+  ++ R       A +     ++     E + KE TE  AS E + 
Sbjct: 1011 KLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM---EQMTKEKTETLASLEDTK 1067

Query: 595  TKTPTISPVITAPPSSPVLDTSDIRK--EPMNIYNLNAI-IRDQIKHL-QKAVDRSLQLS 650
                 +   +     + + +  ++ K  E + + N      R +I+ L Q A  +S QLS
Sbjct: 1068 QTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLS 1127

Query: 651  RQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLK 710
              +    +LA  + + ++ +     KL+   S    Q+  ++       + A+   A+L+
Sbjct: 1128 ALQEENVKLAEELGRSRDEVTSH-QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQ 1186

Query: 711  NKYENEKAMVTET---MTKLRNELKALKEDAATFSSLRAMFATRCDEYV----------T 757
                   A++TE    + KLRNE+  L+ + A+  SL ++  T   + V           
Sbjct: 1187 KSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1246

Query: 758  QLDEMQRQLAAAEDEKKT 775
            QL E +RQL+++     T
Sbjct: 1247 QLKENKRQLSSSSGNTDT 1264



 Score = 70.9 bits (172), Expect = 5e-12
 Identities = 171/848 (20%), Positives = 338/848 (39%), Gaps = 138/848 (16%)

Query: 24   LTETTHEKIQAAEYGLVVLEEKLTLKQQY-DELEAEYDSLKQELEQLKEAFGQSFSIHRK 82
            LTET+    +    G   L+E L  KQQ+ ++L AE D  + E+ +     G+       
Sbjct: 336  LTETSSRYARKIS-GTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGE-IEQELA 393

Query: 83   VAEDGETREETLLQESASK-----EAYYLGKILEMQNELKQSRAVVTNVQ--AENERLTA 135
            +A DG  +    L+    +     EA    K+ E+ N+L++ +  V ++Q   E E +T 
Sbjct: 394  LARDGHDQHVLELEAKMDQLRTMVEAADREKV-ELLNQLEEEKRKVEDLQFRVEEESITK 452

Query: 136  ---VVQDLKENNEMVELQR---IRMKDEIREYKFR------------EARLLQDYTELEE 177
                V  + E + ++EL++   +R++ E+ E + R               LLQ+ + L+E
Sbjct: 453  GDLEVATVSEKSRIMELEKDLALRVQ-EVAELRRRLESNKPAGDVDMSLSLLQEISSLQE 511

Query: 178  ENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALET 237
                  KL  T   +Q E   LK      EE         +  I+    A  +L +  E+
Sbjct: 512  ------KLEVTRTDHQREITSLKEHFGAREETH-------QKEIKALYTATEKLSKENES 558

Query: 238  LKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMN------GHIHG 291
            LK++ E  N   KE S  I+L  + +  ++   + A +  + +    +         +  
Sbjct: 559  LKSKLEHAN---KENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKT 615

Query: 292  PLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQ 351
             + K+  DY+     + E+L    D     +  E++ L+ +LM+V +EK   L  ++   
Sbjct: 616  QIEKMRLDYQ----HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKL 671

Query: 352  TQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDIN 411
             + E       +QH     L E  + +  LQ +                      E+ + 
Sbjct: 672  DKAE-------DQH-----LVEMEDTLNKLQEA----------------------EIKVK 697

Query: 412  GLEILECKYRVAVTEVIDLKAEIKALKEK------YNKSVENYTDEKAKYESKIQMYDEQ 465
             LE+L+ K       + +  +++KA +EK        K+      E  K   +++  ++Q
Sbjct: 698  ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQ 757

Query: 466  VTSLEKTTKESGEKMAHMEKELQ----KMTSIANENHSTLNTAQDELVTFSEELAQLYHH 521
            +  LE        K + + +ELQ    K+T++  EN S ++  ++   T  +EL  L   
Sbjct: 758  IKHLEIEKNAESSKASSITRELQGRELKLTNL-QENLSEVSQVKE---TLEKELQILKEK 813

Query: 522  VCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLAR-RGVSSPVETRTSSEP 580
                + E    V +    Q  V +   L   ++   +LS  L + R   + +E +   + 
Sbjct: 814  FAEASEEA---VSVQRSMQETVNK---LHQKEEQFNMLSSDLEKLRENLADMEAKFREKD 867

Query: 581  VAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAII---RDQIK 637
              +E    +KE        I  +     S       ++R +  ++  L   +    +   
Sbjct: 868  EREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENAS 927

Query: 638  HLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKA 697
             LQK+++     + Q  + +E A   +++K+ L  ++  L+  + T   Q   L+A    
Sbjct: 928  FLQKSIEDMTVKAEQ--SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA---- 981

Query: 698  NKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVT 757
                 E A +  K K+E     + +T+    ++LK  +E+ +                + 
Sbjct: 982  ---RYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL--------------LQ 1024

Query: 758  QLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIG 817
            +L+E+++Q   A+   +T    +++  Q     T+ L  LE   + + + + +L   K  
Sbjct: 1025 ELEELRKQADKAK-AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKEN 1083

Query: 818  SPKIVSSL 825
            + K V  L
Sbjct: 1084 NLKNVEEL 1091



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 119/599 (19%), Positives = 238/599 (39%), Gaps = 76/599 (12%)

Query: 16   EIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ---------EL 66
            E+E L  +L +   EK    E  L  +  KL   +    +E E D+L +         EL
Sbjct: 645  EMEALRAKLMKVIKEK----ENSLEAIRSKLDKAEDQHLVEME-DTLNKLQEAEIKVKEL 699

Query: 67   EQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNV 126
            E L+    +   +        +  EE LL   A ++A   GK     +E+K+ R  +   
Sbjct: 700  EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK-----SEMKKLRQQLEAA 754

Query: 127  QAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLV 186
            + + + L     ++++N E  +   I  + + RE K     L ++ +E+ +   TL+K +
Sbjct: 755  EKQIKHL-----EIEKNAESSKASSITRELQGRELKL--TNLQENLSEVSQVKETLEKEL 807

Query: 187  STLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKN 246
              LK+   E       ++R  +ETV    Q E+   +      +L E L  ++ +  +K+
Sbjct: 808  QILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKD 867

Query: 247  NLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYR----- 301
               ++L +     +N I+  +                KM+G     L K+N + R     
Sbjct: 868  EREEQLIKAKEKLENDIAEIM----------------KMSGDNSSQLTKMNDELRLKERD 911

Query: 302  -----TPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEH 356
                     +  E+ + +     ++ +   Q  ++   + E EK  L   L + + ++E 
Sbjct: 912  VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMET 971

Query: 357  TKGALTEQHERVHRL-----TEHVNAMRGLQSSKELKAELDGE-KGRDSGEEAHDYEVDI 410
            +     E   R  R      T+H   ++ LQ     K  LD E K + + EE      ++
Sbjct: 972  SHNQCQELKARYERATSETKTKHEEILQNLQ-----KTLLDTEDKLKGAREENSGLLQEL 1026

Query: 411  NGLEILECKYRVAVT--EVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQ-MYDEQVT 467
              L     K + A T  + + +  ++   K +   S+E+     AK ++++  + +  + 
Sbjct: 1027 EELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLK 1086

Query: 468  SLEKTTKE------SGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHH 521
            ++E+  K         +KM    KE++ +   A +    L+  Q+E V  +EEL +    
Sbjct: 1087 NVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDE 1146

Query: 522  VCLCNN-ETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSE 579
            V      E    V+ +   + +   S  +K  D+ +  L   ++   ++S + T   +E
Sbjct: 1147 VTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSIS---ITSALLTEKDAE 1202



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 64/254 (25%), Positives = 116/254 (45%), Gaps = 50/254 (19%)

Query: 8    QTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ--- 64
            QT +     +E++TKE TET           L  LE+    KQ   +L+ E D+LK+   
Sbjct: 1040 QTAEDAMQIMEQMTKEKTET-----------LASLED---TKQTNAKLQNELDTLKENNL 1085

Query: 65   -ELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLG---KILEMQNELKQSR 120
              +E+L ++  +  ++  +  E+     ETL Q +A K         + +++  EL +SR
Sbjct: 1086 KNVEELNKS-KELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSR 1144

Query: 121  AVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENI 180
              VT+ Q   E  + +      NN+++E+++            RE++ ++D    +EE  
Sbjct: 1145 DEVTSHQKLEEERSVL------NNQLLEMKK------------RESKFIKD---ADEEKA 1183

Query: 181  TLQKLVS----TLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALE 236
            +LQK +S     L +   E E L++E+     E     S L   ++  E  + +LE  ++
Sbjct: 1184 SLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS-LHSVVQTLESDKVKLELKVK 1242

Query: 237  TLKNEREQKNNLRK 250
             L  E + K N R+
Sbjct: 1243 NL--ELQLKENKRQ 1254


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 154/784 (19%), Positives = 308/784 (39%), Gaps = 143/784 (18%)

Query: 111  EMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQ 170
            E+Q+ + +  A++T  Q +NE    +++ L+E  E++E     + +        EA L +
Sbjct: 280  ELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEH-------EASLSR 332

Query: 171  DYTELEEENITLQKLVSTLKQNQVEY-----EGLKHEIKRFEEETVLLNSQLEDAIRLKE 225
            +    +EE ++LQ+++  + Q  VE      +G  HE     + ++      +DA +   
Sbjct: 333  N---AQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALT 389

Query: 226  IAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNND-DK 284
            +    L    + +++ R+Q    ++ ++     +D          ++ E+G        K
Sbjct: 390  LVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHD----------QWEEEGKALRQRLQK 439

Query: 285  MNGH---IHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKA 341
            + G    + G  V L G+         +SL+   +L  +      ++L+QQL  +E+E  
Sbjct: 440  LTGERDTLAGQTVDLQGEV--------DSLSKERELLQKAR----EELRQQLEVLEQEAW 487

Query: 342  ILLANLQESQTQLEHTKGALTEQHERVH-------RLTEHVNAMRGLQS---SKELKAEL 391
             L     E Q Q +  +G   EQ E +H       RL E +  +   QS   S+ +    
Sbjct: 488  RLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLRE 547

Query: 392  DGEKGRDSGEEAHDYEVDING--------LEILECKYRVAVTEVIDLKA---EIKALKEK 440
              E     GE     + ++          +  L        TEV DL+A   ++ AL E 
Sbjct: 548  ALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEA 607

Query: 441  Y-------NKSVENYTDEKAKYESKIQMYDEQVTSL-------EKTTKESGEKMAHMEKE 486
                    N+ +    +E     S+++  ++   +L       EK  +   EK  H+E +
Sbjct: 608  LALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQ 667

Query: 487  LQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRS 546
            LQK      E  + L   Q+E     ++L++  H       E     +   +++++    
Sbjct: 668  LQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH-----QQEAATTQLEQLHQEAKRQEE 722

Query: 547  GSLKGPDDPRGLLSPRLARRGVSSPVETRTSS-EPVAKESTEASKEPSPTKTPTISPVIT 605
               +   +   L+  + A       +E R  + E   ++  E  +  S  K    S +  
Sbjct: 723  VLARAVQEKEALVREKAA-------LEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE 775

Query: 606  APPSSPVLDTS--DIRKEPMNIYNLNAIIRDQIKHLQKAVD--RSLQLSRQRAAARELAP 661
            A   + V++ +   +  +   +     +I+ +++ L+  +D  RS     + AAAR+LA 
Sbjct: 776  AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQ 835

Query: 662  MIDKDK------------------------------------EALMEEILKLKSLLSTKR 685
               + K                                    E+L  E ++L+  L  ++
Sbjct: 836  AEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQ 895

Query: 686  EQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNE-------LKALKEDA 738
             ++  ++A  +  +  AE AL  ++ + E E+  + ET+ + + E       L+ L++D 
Sbjct: 896  TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM 955

Query: 739  ATFSSLRAMFATRCDEYVTQLDEMQRQLAAA----EDEKKTLNTLLRMAIQQKLALTQRL 794
                 L+    T   +  TQL E QR+L  A     D+   L       +Q K+ L +++
Sbjct: 956  KV-QKLKEQETTGILQ--TQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQV 1012

Query: 795  EDLE 798
            EDL+
Sbjct: 1013 EDLK 1016



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 178/854 (20%), Positives = 341/854 (39%), Gaps = 109/854 (12%)

Query: 8    QTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQY-DELEAEYDSLKQEL 66
            QT D  + ++++L + LT+T  EK Q     L  L+ +L+  Q+   + E + +SL+ EL
Sbjct: 1257 QTRDVLRDQVQKLEERLTDTEAEKSQV-HTELQDLQRQLSQNQEEKSKWEGKQNSLESEL 1315

Query: 67   EQLKEAFGQSFS-IHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTN 125
             +L E      S + R   +  E + E  L ++A +      ++  +Q  + ++RA  + 
Sbjct: 1316 MELHETMASLQSRLRRAELQRMEAQGERELLQAAKENL--TAQVEHLQAAVVEARAQASA 1373

Query: 126  VQAENERLTAVVQDLKENNEMVELQRIRMK--DEIREYKFREARLLQD--------YTEL 175
                 E L      LK  NE VE +R R +   E  E K  + + LQ+          E 
Sbjct: 1374 AGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAER 1433

Query: 176  EEENITLQKLVSTL-KQNQVE---YEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEH-- 229
            EEE  TL+  +  L KQ +++    E L  ++K+  +E  L   Q+++  + + + EH  
Sbjct: 1434 EEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLP 1493

Query: 230  ------------QLEEALETLKNEREQKNNLRKEL--------------SQYISLNDNHI 263
                        Q E+  E  K+   Q+N L  +L               Q   L    +
Sbjct: 1494 MAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLV 1553

Query: 264  SISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNI 323
            ++    L+  E+  +     K+       + +L G   T  +    +L  ++ L  E   
Sbjct: 1554 TLECLALELEENHHKMECQQKL-------IKELEGQRETQRV----ALTHLT-LDLEERS 1601

Query: 324  SEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAM-RGLQ 382
             E+Q    Q+  +E    +L   LQE   +++  +  + E   +   LT+ +    + L 
Sbjct: 1602 QELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELM 1661

Query: 383  SSKELKAELDGEKGRDSGEEAHDYEVDINGLEI-LECKYRVAVTE---VIDLKAEIKALK 438
              KE    L+ ++ R    +    E D+  +++ L  + R   T+   + +   E K   
Sbjct: 1662 LQKERIQVLEDQRTR----QTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPS 1717

Query: 439  EKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENH 498
            +    S+E+        E +++   E +  L++   +       +E++LQ +     E  
Sbjct: 1718 KAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQ-------LEQQLQGLHRKVGETS 1770

Query: 499  STLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGL 558
              L+  + E+V   ++L +      L   E   +  LD  +++   R   L+       L
Sbjct: 1771 LLLSQREQEIVVLQQQLQEAREQGEL--KEQSLQSQLDEAQRALAQRDQELE------AL 1822

Query: 559  LSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDI 618
               +   +G    V+ +  +   A E    + +    +                ++   +
Sbjct: 1823 QQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRV 1882

Query: 619  RKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLK 678
            +     + +L A  R+Q K L       L L +Q A   E A   + +  AL +  L+ +
Sbjct: 1883 QALEEVLGDLRAESREQEKAL-------LALQQQCA---EQAQEHEVETRALQDSWLQAQ 1932

Query: 679  SLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDA 738
            ++L  + +++  LRA  ++++   E A A    + E  +  + +    L+ + + L E A
Sbjct: 1933 AVLKERDQELEALRAESQSSRHQEEAARA----RAEALQEALGKAHAALQGKEQHLLEQA 1988

Query: 739  ATFSSLRAMFAT------RCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQ-KLALT 791
                SL A  AT       C  +  QL+E    L   E E +  +   +  +QQ + AL 
Sbjct: 1989 ELSRSLEASTATLQASLDACQAHSRQLEE---ALRIQEGEIQDQDLRYQEDVQQLQQALA 2045

Query: 792  QRLEDLEFDHEQSR 805
            QR E+L   H+Q R
Sbjct: 2046 QRDEELR--HQQER 2057



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 159/802 (19%), Positives = 320/802 (39%), Gaps = 80/802 (9%)

Query: 8    QTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELE 67
            Q  D ++ E + L + L + T E+   A   + +  E  +L ++ + L+   + L+Q+LE
Sbjct: 421  QQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLE 480

Query: 68   QLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQ 127
             L++   +   ++ ++   G++ +    Q+   +E  +L        E ++ + ++  ++
Sbjct: 481  VLEQEAWRLRRVNVELQLQGDSAQG---QKEEQQEELHLA-----VRERERLQEMLMGLE 532

Query: 128  AENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVS 187
            A+     + +  L+E  E   L+   ++ E  E     AR  Q   EL     TL+  V+
Sbjct: 533  AKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592

Query: 188  TLKQNQVEYE-----------GLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALE 236
             L+   V+             GL  ++ + EEE   + S++E A + +   +  L EA +
Sbjct: 593  DLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEK 652

Query: 237  TLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGH----IHGP 292
              +   E+  +L  +L +     +    +  D     E+  E       + H        
Sbjct: 653  RREALWEKNTHLEAQLQK---AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQ 709

Query: 293  LVKLNGDYRTPTLRKGESLNPVSDLFSELNISEI---------QKLKQQLMQVEREKAIL 343
            L +L+ + +        ++     L  E    E+         Q L +QL  +   K +L
Sbjct: 710  LEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELL 769

Query: 344  LANLQESQTQ---LEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSG 400
             ++L E+Q Q   +E TKG L  Q + V +  E +         + LK ELD E  R   
Sbjct: 770  ESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG-----EVRCLKLELDTE--RSQA 822

Query: 401  EEAHD------YEVDINGLEILECKYRVAVTEVIDLK----AEIKALKEKYNKSVENYTD 450
            E+  D       + +  G   LE +      EV  L+     E    +++  K++E+   
Sbjct: 823  EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLER 882

Query: 451  EKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKEL-QKMTSIANENHSTLNT---AQD 506
            EK + E +++   EQ T +E    +  E+    E  L Q       E  S L T    Q 
Sbjct: 883  EKMELEMRLK---EQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQK 939

Query: 507  ELVTFSEELAQLYHHV---CLCNNETPNRVMLDYYRQSRVTRSGSLKGPDD-------PR 556
            EL   S++L +L   +    L   ET   +        R  +  + +  DD         
Sbjct: 940  ELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESS 999

Query: 557  GLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTP---TISPVITAPPSSPVL 613
             LL  ++  +     ++++  ++  ++   E   +    +T     I   +    +S  L
Sbjct: 1000 SLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL 1059

Query: 614  DTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEA--LM 671
               +  +  + +   ++I + ++  L++ +  +    ++ +A  EL     K+KEA  L 
Sbjct: 1060 SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLA 1119

Query: 672  EEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNEL 731
            +E   L+ L ++   +   LRA L A +  A      L++     +A+  E      N+ 
Sbjct: 1120 QEAQLLEELEASHITE-QQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQP--GNQA 1176

Query: 732  KALKEDAATFSSLRAMFATRCD 753
            +A  + A+ +S+L+    + C+
Sbjct: 1177 QAQAQLASLYSALQQALGSVCE 1198



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 170/829 (20%), Positives = 333/829 (40%), Gaps = 95/829 (11%)

Query: 8    QTVDHYKTEIERLTKELTETT--HEKIQAA--EYGLVVLEEKLTLKQQYDELE----AEY 59
            +T    +T+++   +EL E    H    AA  E    +L++K+ L++Q ++L+    A+ 
Sbjct: 964  ETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQD 1023

Query: 60   DSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQS 119
            DS +   ++++E   ++   +R + ++ E  + +L      KE   L  +L+  + ++Q 
Sbjct: 1024 DSQRLVEQEVQEKLRETQEYNR-IQKELEREKASLTLSLMEKEQRLL--VLQEADSIRQQ 1080

Query: 120  RAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEEN 179
                  + A  + +     + KE +  +EL R  +K++  ++  +EA+LL+   ELE  +
Sbjct: 1081 E-----LSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLE---ELEASH 1132

Query: 180  ITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLK 239
            IT Q+L ++L   + +   L+  ++  E +   L ++ +   + +  A+ QL      L+
Sbjct: 1133 ITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQ--AQAQLASLYSALQ 1190

Query: 240  NEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVK-LNG 298
                     R ELS          + SV GL       EP+ +   +    GPL+  L+ 
Sbjct: 1191 QALGSVCESRPELS-----GGGDSAPSVWGL-------EPDQNGARSLFKRGPLLTALSA 1238

Query: 299  DYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTK 358
            +     L K       +    ++   ++QKL+++L   E EK+ +   LQ+ Q QL   +
Sbjct: 1239 EAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQ 1298

Query: 359  GALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILEC 418
                          E  +   G Q+S  L++EL          E H+       +  L+ 
Sbjct: 1299 --------------EEKSKWEGKQNS--LESEL---------MELHE------TMASLQS 1327

Query: 419  KYRVAVTEVIDLKAE---IKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKE 475
            + R A  + ++ + E   ++A KE     VE+   + A  E++ Q     +   +  T  
Sbjct: 1328 RLRRAELQRMEAQGERELLQAAKENLTAQVEHL--QAAVVEARAQASAAGILEEDLRTAR 1385

Query: 476  SGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPN-RVM 534
            S  K+ + E E ++  + A +    L  AQ +     E LA L   +     E    R  
Sbjct: 1386 SALKLKNEEVESERERAQALQEQGELKVAQGK--ALQENLALLTQTLAEREEEVETLRGQ 1443

Query: 535  LDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSP 594
            +    + R  +  +L+       LLS  L +R     ++     E    E   +  E  P
Sbjct: 1444 IQELEKQREMQKAALE-------LLSLDLKKRNQEVDLQQEQIQE---LEKCRSVLEHLP 1493

Query: 595  TKTPTISPVITAPPSSPVLDTSDIRKEPMNIYN---LNAIIRDQIKHLQK--AVDRSLQL 649
                     +T      + +    R+   N+     L    +DQ+   Q+    D   QL
Sbjct: 1494 MAVQEREQKLTV-QREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL 1552

Query: 650  SRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANL 709
                  A EL     K  E   + I +L+    T+R  +  L   L+   Q  +   + +
Sbjct: 1553 VTLECLALELEENHHK-MECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQI 1611

Query: 710  KNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAA 769
             +  E+   ++   + +   E+K+ +E        +       +    +L   + ++   
Sbjct: 1612 -HDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVL 1670

Query: 770  EDEKKTLNTLLRMAIQQ-KLALTQRLEDLEFDHE--QSRRSKGKLGKSK 815
            ED++     +L   ++Q KL+L +R  +L    +  Q R  +GK G SK
Sbjct: 1671 EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGK-GPSK 1718



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 178/860 (20%), Positives = 332/860 (38%), Gaps = 146/860 (16%)

Query: 4    EEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLK 63
            EE+ + +   + + E  T +L +   E  +  E     ++EK  L ++   LE    +++
Sbjct: 690  EEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVE 749

Query: 64   QELEQLKEAFGQSFSIHRKVAEDG--------------ETREETLLQESASKEAYYLGKI 109
            ++ + L E   Q  S  +++ E                + + E  +Q     +    G++
Sbjct: 750  RDRQDLAEQL-QGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEV 808

Query: 110  ----LEMQNELKQSR-----AVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIRE 160
                LE+  E  Q+      A     QAE E  TA+ Q    + +  E+ ++R K E +E
Sbjct: 809  RCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEK--EVNQLREKWE-KE 865

Query: 161  YKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGL--KHEIKRFEEETVLLNSQLE 218
              + +  L +    LE E + L+     LK+ Q E E +  + E +R + E+ L   QLE
Sbjct: 866  RSWHQQELAKALESLEREKMELE---MRLKEQQTEMEAIQAQREEERTQAESALCQMQLE 922

Query: 219  ---DAIRL--------KEIAE--HQLEEALETLK----NEREQKNNLRKELSQYISLNDN 261
               + + L        KE+A+   QLE   + +K     E+E    L+ +L +       
Sbjct: 923  TEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKE 982

Query: 262  HISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSEL 321
                  D L   ++ S     DKM+      L K   D ++  + + +S   V     E 
Sbjct: 983  AARQHRDDLAALQEESSSLLQDKMD------LQKQVEDLKSQLVAQDDSQRLVEQEVQE- 1035

Query: 322  NISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGL 381
             + E Q+  +   ++EREKA L  +L E + +L   + A + + + +  L + +   +G 
Sbjct: 1036 KLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGE 1095

Query: 382  QSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKY 441
            Q  KEL A+++  +     +EA     +   LE LE  +   +TE   L+A + A + K 
Sbjct: 1096 Q--KELSAQMELLRQEVKEKEADFLAQEAQLLEELEASH---ITEQ-QLRASLWAQEAK- 1148

Query: 442  NKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTL 501
                       A+ + +++  + Q+ +L                        A +     
Sbjct: 1149 ----------AAQLQLRLRSTESQLEAL-----------------------AAEQQPGNQ 1175

Query: 502  NTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSP 561
              AQ +L +    L Q    VC                +SR   SG         GL   
Sbjct: 1176 AQAQAQLASLYSALQQALGSVC----------------ESRPELSGGGDSAPSVWGLEPD 1219

Query: 562  RLARRGV--SSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIR 619
            +   R +    P+ T  S+E VA    +  ++   T+                  T D+ 
Sbjct: 1220 QNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQ-----------------QTRDVL 1262

Query: 620  KEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKS 679
            ++   +  L   + D      +       L RQ +  +E     +  + +L  E+++L  
Sbjct: 1263 RD--QVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHE 1320

Query: 680  LLSTKREQIATL---RAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKE 736
             +++ + ++      R   +  ++  + A  NL  + E+ +A V E   +  +    L+E
Sbjct: 1321 TMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQ-ASAAGILEE 1379

Query: 737  DAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLA-LTQRLE 795
            D  T    R+    + +E      E +R+ A A  E+  L      A+Q+ LA LTQ L 
Sbjct: 1380 DLRT---ARSALKLKNEEV-----ESERERAQALQEQGELKVAQGKALQENLALLTQTLA 1431

Query: 796  DLEFDHEQSRRSKGKLGKSK 815
            + E + E  R    +L K +
Sbjct: 1432 EREEEVETLRGQIQELEKQR 1451



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 193/847 (22%), Positives = 339/847 (40%), Gaps = 131/847 (15%)

Query: 2    AAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQY--DELEAEY 59
            AA ++ Q     KT +E+      +  HEK       +  L EK   ++ +   EL    
Sbjct: 829  AARQLAQAEQEGKTALEQ-----QKAAHEK------EVNQLREKWEKERSWHQQELAKAL 877

Query: 60   DSL---KQELE-QLKEAFGQSFSIHRKVAEDGETREETLLQ---ESASKEAYYLGKILEM 112
            +SL   K ELE +LKE   +  +I  +  E+    E  L Q   E+  +    L  +L+ 
Sbjct: 878  ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQT 937

Query: 113  QNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDY 172
            Q EL  +     + Q E  R    VQ LKE  E   + + ++++  RE K    +   D 
Sbjct: 938  QKELADA-----SQQLERLRQDMKVQKLKEQ-ETTGILQTQLQEAQRELKEAARQHRDDL 991

Query: 173  TELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLE 232
              L+EE+       S+L Q++++ +      K+ E+    L SQL      + + E +++
Sbjct: 992  AALQEES-------SSLLQDKMDLQ------KQVED----LKSQLVAQDDSQRLVEQEVQ 1034

Query: 233  EAL-ETLKNEREQKNNLRKELSQYISLNDNHISISV----DGLKFAEDGSEPNNDDKMNG 287
            E L ET +  R QK   R++ S  +SL +    + V    D ++  E  +   +  +  G
Sbjct: 1035 EKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQG 1094

Query: 288  HIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEI--QKLKQQLMQVEREKAILLA 345
                   ++    +    ++ + L   + L  EL  S I  Q+L+  L   E + A L  
Sbjct: 1095 EQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQL 1154

Query: 346  NLQESQTQLEHTKGALT--EQHERVHRLTEHVNAMR-GLQSSKELKAELDGEKGRDSGEE 402
             L+ +++QLE          Q +   +L    +A++  L S  E + EL G  G DS   
Sbjct: 1155 RLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSG--GGDSAPS 1212

Query: 403  AHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMY 462
                E D NG   L    R  +   +  +A   AL + +         +  K +    + 
Sbjct: 1213 VWGLEPDQNGARSLF--KRGPLLTALSAEAVASALHKLHQ--------DLWKTQQTRDVL 1262

Query: 463  DEQVTSLEK--TTKESGEKMAHME-KELQKMTSIANENHS----TLNTAQDELVTFSEEL 515
             +QV  LE+  T  E+ +   H E ++LQ+  S   E  S      N+ + EL+   E +
Sbjct: 1263 RDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM 1322

Query: 516  AQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLK-GPDDPRGLLSPRLARRGVSSPVET 574
            A L                     QSR+ R+   +      R LL  + A+  +++ VE 
Sbjct: 1323 ASL---------------------QSRLRRAELQRMEAQGERELL--QAAKENLTAQVEH 1359

Query: 575  RTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRD 634
              ++   A+    A+          +   +    S+  L   ++  E      L    + 
Sbjct: 1360 LQAAVVEARAQASAA--------GILEEDLRTARSALKLKNEEVESERERAQALQE--QG 1409

Query: 635  QIKHLQ-KAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRA 693
            ++K  Q KA+  +L L  Q  A RE      ++ E L  +I +L+     ++  +  L  
Sbjct: 1410 ELKVAQGKALQENLALLTQTLAERE------EEVETLRGQIQELEKQREMQKAALELLSL 1463

Query: 694  VLKANKQTAEV------ALANLKNKYENEKAMVTETMTKL---RNELKALKEDAATFSSL 744
             LK   Q  ++       L   ++  E+    V E   KL   R +++ L++D  T    
Sbjct: 1464 DLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRET---Q 1520

Query: 745  RAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQ-----QKLALTQRL-EDLE 798
            R +   +  E   +   ++ Q    +D KK L TL  +A++      K+   Q+L ++LE
Sbjct: 1521 RNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELE 1580

Query: 799  FDHEQSR 805
               E  R
Sbjct: 1581 GQRETQR 1587



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 155/847 (18%), Positives = 319/847 (37%), Gaps = 110/847 (12%)

Query: 8    QTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELE 67
            Q++    +    L  E+ +     ++ +     +  +K+ L QQ  +LE E  S+   +E
Sbjct: 575  QSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRME 634

Query: 68   QLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQ 127
              ++A     ++   +AE  E R E L +++   EA  L K  E   EL+   A + ++Q
Sbjct: 635  AAEQARN---ALQVDLAE-AEKRREALWEKNTHLEAQ-LQKAEEAGAELQ---ADLRDIQ 686

Query: 128  AENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVS 187
             E E +   + + +   E    Q  ++  E +  +   AR +Q+   L  E   L+  + 
Sbjct: 687  EEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQ 746

Query: 188  TLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLK---EIAEHQLEEALETLKNERE- 243
             +++++   + L  +++       LL S L +A +     E+ + QLE  ++T+   +E 
Sbjct: 747  AVERDR---QDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEV 803

Query: 244  ---QKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDY 300
               +   L+ EL    S  +     +   L  AE   +   + +   H            
Sbjct: 804  IQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAH------------ 851

Query: 301  RTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGA 360
                    + +N + + + +      Q+L + L  +EREK  L   L+E QT++E    A
Sbjct: 852  -------EKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEME----A 900

Query: 361  LTEQHERVHRLTEHVNAMRGLQSSKE----LKAELDGEKG-RDSGEEAHDYEVDINGLEI 415
            +  Q E      E       L++ KE    L+  L  +K   D+ ++      D+   ++
Sbjct: 901  IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKL 960

Query: 416  LECKYR-VAVTEVIDLKAEIK-----------ALKEKYN----------KSVENYTDEKA 453
             E +   +  T++ + + E+K           AL+E+ +          K VE+   +  
Sbjct: 961  KEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLV 1020

Query: 454  KYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSE 513
              +   ++ +++V    + T+E       +E+E   +T    E    L   Q+      +
Sbjct: 1021 AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQ 1080

Query: 514  ELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARR-----GV 568
            EL+ L                    RQ      G  K       LL   +  +       
Sbjct: 1081 ELSAL--------------------RQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQ 1120

Query: 569  SSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNL 628
             + +     +  + ++   AS      K   +   + +  S   L+     ++P N    
Sbjct: 1121 EAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQ--LEALAAEQQPGNQAQA 1178

Query: 629  NAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQI 688
             A +      LQ+A+    +   + +   + AP +      L  +    +SL   KR  +
Sbjct: 1179 QAQLASLYSALQQALGSVCESRPELSGGGDSAPSV----WGLEPDQNGARSLF--KRGPL 1232

Query: 689  ATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMF 748
             T    L A       A+A+  +K   +     +T   LR++++ L+E      + ++  
Sbjct: 1233 LT---ALSAE------AVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQV 1283

Query: 749  ATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSK 808
             T   +   QL + Q + +  E ++ +L + L    +   +L  RL   E    +++  +
Sbjct: 1284 HTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGER 1343

Query: 809  GKLGKSK 815
              L  +K
Sbjct: 1344 ELLQAAK 1350



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 131/586 (22%), Positives = 225/586 (38%), Gaps = 112/586 (19%)

Query: 2    AAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDS 61
            A EEVL  +     E E+    L +   E+ Q  E       E   L+  + + +A    
Sbjct: 1884 ALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEV------ETRALQDSWLQAQAVLKE 1937

Query: 62   LKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRA 121
              QELE L+     S    R   E    R E L +      A   GK   +  + + SR+
Sbjct: 1938 RDQELEALRAESQSS----RHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRS 1993

Query: 122  VVTNV----------QAENERLTAVV---------QDLKENNEMVELQRI--RMKDEIRE 160
            +  +           QA + +L   +         QDL+   ++ +LQ+   +  +E+R 
Sbjct: 1994 LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRH 2053

Query: 161  YKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDA 220
             + RE  L +   +  +EN+  +K     ++ + E  GL   ++           QL  A
Sbjct: 2054 QQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVREL---------QLTLA 2104

Query: 221  IRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPN 280
             + +EI E            E +Q+NNL        +L  +H +  ++      D  EP 
Sbjct: 2105 QKEQEILE----------LRETQQRNNLE-------ALPHSHKTSPMEEQSLKLDSLEP- 2146

Query: 281  NDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSEL-----NISEIQKLKQ--QL 333
                    +   L +L    R    R+ E      DL   L     ++S +Q++    Q 
Sbjct: 2147 -------RLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQA 2199

Query: 334  MQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDG 393
              +ER+     +  Q  Q +LE T+ AL  + ER+H          G  S+ EL +   G
Sbjct: 2200 SVLERD-----SEQQRLQDELELTRRAL--EKERLH--------SPGATSTAELGSR--G 2242

Query: 394  EKGRDSGE-EAHDYEVDINGLEILECKYRVAVTEVIDLKAEI-KALKEKYNKSVENYTDE 451
            E+G   GE    + E   +G+E    + R+   +    + EI ++  +++N  + +  ++
Sbjct: 2243 EQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ 2302

Query: 452  KAKYESKIQ---MYDEQVTSLE--KTTKES-------GEKM--AHMEKELQKMTSIANEN 497
              +   K++   M   Q  SLE  K T  S       G+K   A    ELQK   +    
Sbjct: 2303 VERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQ 2362

Query: 498  HSTLNTAQDELVT----FSEELAQLYH---HVCLCNNETPNRVMLD 536
             +     + + +T     S ELA L+H   H  L   + P   +L+
Sbjct: 2363 LTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLE 2408



 Score = 30.4 bits (67), Expect = 7.1
 Identities = 22/100 (22%), Positives = 44/100 (44%), Gaps = 10/100 (10%)

Query: 620 KEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKS 679
           +EP  +  L A  ++  K   +     +QL  Q           D +K  L + + +L +
Sbjct: 241 REPAQLLLLLAKTQELEKEAHERSQELIQLKSQG----------DLEKAELQDRVTELSA 290

Query: 680 LLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAM 719
           LL+  ++Q      ++KA ++T E+   N     E+E ++
Sbjct: 291 LLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASL 330


>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
          Length = 1140

 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 145/749 (19%), Positives = 302/749 (40%), Gaps = 95/749 (12%)

Query: 110 LEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRI--RMKDEIREYKFREAR 167
           L+M  ++ Q   V+  +  +N+   + +Q LK+ +E  E+Q+I    +++I +YK +   
Sbjct: 42  LKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEE-EIQQILAETREKILQYKSKVTE 100

Query: 168 LLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFE--------EETVLLNSQLED 219
            L    +++    +L+  +   +Q   E+E  KH ++  +        +  V ++ ++E+
Sbjct: 101 ELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSREVEE 160

Query: 220 AIR-----LKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAE 274
             R     L+   + Q++   +      + +   R+E+ + +    +H +    G + AE
Sbjct: 161 IRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQEKAE 220

Query: 275 D--GSEPNNDDKMNGHIHGPLVKLNGDY-------------RTPTLRKGE---------S 310
           +    E  + +KM   +     KL  DY                TL++ +         S
Sbjct: 221 ELHRMEVESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRSQLFTAESLQAS 280

Query: 311 LNPVSDLFSELNISE------IQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQ 364
               +DL  E    E      I KLK +L  V+ E   LL   Q+ QT L   +  +   
Sbjct: 281 KEKEADLRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVL 340

Query: 365 HERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAV 424
            +++    E   A+  L   KE+++EL   + R   ++A D  +  + + +L+       
Sbjct: 341 QKQLDDAKEGEMAL--LSKHKEVESELAAARER-LQQQASDLVLKASHIGMLQATQMTQE 397

Query: 425 TEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDE----QVTSLEKTTKESGE-K 479
             + DL++E    K + N+ +    +E+A   SK Q  DE    Q+  LEK   E+   +
Sbjct: 398 VTIKDLESE----KSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQ 453

Query: 480 MAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYR 539
             + E+EL+ + S   E  + LN A  + +   EELA  +H      +    R       
Sbjct: 454 QEYYERELKNLQSRLEEEVTQLNEAHSKTL---EELAWKHHMAIEAVHSNAIRDKKKLQM 510

Query: 540 QSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPT 599
                 +      ++ +  L   L         +  T+++ +        K      +  
Sbjct: 511 DLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAE 570

Query: 600 ISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAAREL 659
                       + +  D+ K+ +         +D + +++  +++  Q   +  AA + 
Sbjct: 571 GLIASLQDSQERLQNELDLTKDSLK------ETKDALLNVEGELEQERQQHEETIAAMKE 624

Query: 660 APMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAM 719
              +  DK A   EI   ++L    R++ + LR  L+   +             E++K+ 
Sbjct: 625 EEKLKVDKMAHDLEIKWTENL----RQECSKLREELRLQHE-------------EDKKSA 667

Query: 720 VTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKT-LNT 778
           +++ +     +LK  +++AA     R  +  + ++ + Q+  +++ L     + +T L  
Sbjct: 668 MSQLL-----QLKDREKNAA-----RDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQ 717

Query: 779 LLRMAIQQKLALTQRLEDLEFDHEQSRRS 807
           L     Q++  LTQ LE+LE  H+Q  +S
Sbjct: 718 LQAQFTQERQRLTQELEELEEQHQQRHKS 746



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 151/872 (17%), Positives = 360/872 (41%), Gaps = 124/872 (14%)

Query: 4   EEVLQTVDHYKTEIERLTKELTETT--HEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDS 61
           EE+ Q +   + +I +   ++TE      KIQ  E  L   E+ + +KQQ      E+++
Sbjct: 78  EEIQQILAETREKILQYKSKVTEELDLRRKIQVLESSL---EDHIKMKQQ---ALTEFEA 131

Query: 62  LKQELEQLK-----EAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQN-E 115
            K  +E ++     +   +  ++ R+V E     EE L      +  +   K L +++ +
Sbjct: 132 YKHRVEDMQLCAEAQHVQRIVTMSREVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQ 191

Query: 116 LKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYT-E 174
               R +   ++++ +   +V +  ++  E+  ++   +   + E +    +L++DY  +
Sbjct: 192 AAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDYEGK 251

Query: 175 LEEENITLQKLVSTLKQNQV------------------EYEG-----------LKHEIKR 205
           L +     ++ + TLK++Q+                  E++G           LK E++ 
Sbjct: 252 LNKAQSFYERELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQM 311

Query: 206 FEEETVLLNSQ---LEDAIRLKE----IAEHQLEEALE----TLKNEREQKNNL---RKE 251
            ++E   L  +   L+ A+ + E    + + QL++A E     L   +E ++ L   R+ 
Sbjct: 312 VQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAARER 371

Query: 252 LSQYIS---LNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKG 308
           L Q  S   L  +HI + +   +  ++ +  + + + +  ++  L +L  + R     K 
Sbjct: 372 LQQQASDLVLKASHIGM-LQATQMTQEVTIKDLESEKS-RVNERLSQLEEE-RAFLRSKT 428

Query: 309 ESLNPVSD---LFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQH 365
           +SL+       L  E  ++E ++ +Q+    ERE   L + L+E  TQL        E+ 
Sbjct: 429 QSLDEEQKQQILELEKKVNEAKRTQQEYY--ERELKNLQSRLEEEVTQLNEAHSKTLEEL 486

Query: 366 ERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDS---GEEAHDYEVDINGL-EILECKYR 421
              H +         ++  K+L+ +L+ +  +D     E+ +  + ++  L E+LE K  
Sbjct: 487 AWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLN 546

Query: 422 VAVTEVIDLKAEIKALKEKYNKS---VENYTDEKAKYESKIQMYDEQVTSLEKTTKESGE 478
            A  E+  L+  ++  ++    +   + +  D + + ++++ +  + +       KE+ +
Sbjct: 547 TANQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSL-------KETKD 599

Query: 479 KMAHMEKELQKMTSIANENHSTL---------NTAQDELVTFSEELAQLYHHVCLCNNET 529
            + ++E EL++      E  + +           A D  + ++E L Q     C   ++ 
Sbjct: 600 ALLNVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQ----EC---SKL 652

Query: 530 PNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEAS 589
              + L +    +   S  L+  D  +       AR      VE   +   + K++ E  
Sbjct: 653 REELRLQHEEDKKSAMSQLLQLKDREK-----NAARDSWQKKVEDLLNQISLLKQNLEIQ 707

Query: 590 KEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPM----NIYNLNAIIRDQIKHLQKAVDR 645
              S T    +    T        +  ++ ++      ++   + +    ++  ++   R
Sbjct: 708 LSQSQTSLQQLQAQFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQR 767

Query: 646 SLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVA 705
           +L+   Q+  + EL  + D  +E++    ++++  L T R ++          +   +  
Sbjct: 768 ALENHLQQKHSAELQSLKDAHRESMEGFRIEMEQELQTLRFEL----------EDEGKAM 817

Query: 706 LANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATR--CDEYVTQLDEMQ 763
           LA+L+++  ++ A   + +    ++  A    AA     R++  +R    E++ ++ ++Q
Sbjct: 818 LASLRSELNHQHAAAIDLLRHNHHQELA----AAKMELERSIDISRRQSKEHICRITDLQ 873

Query: 764 RQLAAAEDEKKTLNTLLRMAIQQKLALTQRLE 795
            +L   E     L+  ++   +   ALT+ LE
Sbjct: 874 EELRHREHHISELDKEVQHLHENISALTKELE 905



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 48/215 (22%), Positives = 100/215 (46%), Gaps = 55/215 (25%)

Query: 627 NLNAIIRDQIKHLQKAV-DRSLQLSRQRAAARELAPMIDKDKEALMEEI-LKLKSLL--- 681
           +L A  R +I+ L K+  D S  +++ +  A EL  M  +    ++EE+ L+ K L+   
Sbjct: 189 DLQAAHRREIQELLKSQQDHSASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDY 248

Query: 682 ----------------STKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMT 725
                           + KR Q+ T  + L+A+K+      A+L+ +++ ++A++ +T+ 
Sbjct: 249 EGKLNKAQSFYERELDTLKRSQLFTAES-LQASKEKE----ADLRKEFQGQEAILRKTIG 303

Query: 726 KLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQ 785
           KL+ EL+ ++++A +                  LD+ Q+           L T L +A  
Sbjct: 304 KLKTELQMVQDEAGSL-----------------LDKCQK-----------LQTALAIAEN 335

Query: 786 QKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPK 820
               L ++L+D + + E +  SK K  +S++ + +
Sbjct: 336 NVQVLQKQLDDAK-EGEMALLSKHKEVESELAAAR 369


>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
          Length = 976

 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 124/583 (21%), Positives = 247/583 (42%), Gaps = 90/583 (15%)

Query: 4   EEVLQTVDHYKTEIERLTKE----LTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEY 59
           E++      YK EI    K+    L + T ++ +  +   ++ E +  + Q  ++ + + 
Sbjct: 248 EKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQS 307

Query: 60  DSLKQ----------ELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKI 109
           ++LKQ          ELE +K +  +S S  + + ED +   +T+ Q +  KE       
Sbjct: 308 ENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQ----- 362

Query: 110 LEMQNELKQSRAVV-----TNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFR 164
           +E  N+ + + + V     T V +  E L    Q L++N + +++  + ++ +  E +  
Sbjct: 363 MEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEM 422

Query: 165 EARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLK 224
                    ELEE    L +  + L +N+ ++E +  E+K  E+E + L    E  +   
Sbjct: 423 TKLTNNKEVELEELKKVLGEKETLLYENK-QFEKIAEELKGTEQELIGLLQAREKEVHDL 481

Query: 225 EI-------AEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGS 277
           EI       +E    + ++ LK E E +     EL+ + +       +S++  +  ++ S
Sbjct: 482 EIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCN------KLSLENKELTQETS 535

Query: 278 EPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVE 337
           +      M   +      +N + +    R  + +  + +  ++L  +E++ ++++L Q  
Sbjct: 536 D------MTLELKNQQEDINNNKKQEE-RMLKQIENLQETETQLR-NELEYVREELKQKR 587

Query: 338 REKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMR--GLQSSKEL-------- 387
            E   +   L +S+    + +  +  +++ +  L +   A++  G   SK+L        
Sbjct: 588 DE---VKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVN 644

Query: 388 KAELDGEKGRDS-GEEAHDYEVDINGLEILEC-------KYRVAVTEVIDLK-------- 431
           K EL+ E  +   GE    Y+ +I   +I E        K +V   E + L+        
Sbjct: 645 KLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQ 704

Query: 432 ---AEIKALKEK----YNKSVENYTDEKAKYESKIQMYDEQVTSLE------KTTKESGE 478
              AE+ AL EK    Y+K +E    E   Y+SK Q       SLE      K    S +
Sbjct: 705 HKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVK 764

Query: 479 KMAHMEK-ELQKMTSIANENHSTLNTAQDELV-TFSEELAQLY 519
           K   +E+ E +K+   A EN +TL   +D+   TF  E  ++Y
Sbjct: 765 KQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIY 807



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 158/741 (21%), Positives = 297/741 (40%), Gaps = 113/741 (15%)

Query: 22  KELTETTHEKIQAAEYGLVVLEEKLTLK-----QQYDELEAEYDSLKQELEQLKEAFGQS 76
           +++ E   + IQ  ++G     EK++LK     Q+  +L  E ++ +     LKE   +S
Sbjct: 138 RKIIEAQRKAIQELQFG----NEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARS 193

Query: 77  FSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAV 136
               +K   + E   +  +  + + E     K++    EL+        VQAEN RL   
Sbjct: 194 AEKTKKYEYEREETRQVYMDLNNNIE-----KMITAFEELR--------VQAENSRLEMH 240

Query: 137 VQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEY 196
            + LKE+ E ++      K EI + + + + LL   TE E +   L  L+          
Sbjct: 241 FK-LKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLL---------- 289

Query: 197 EGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYI 256
           E  + ++ + EE+T L +  L+ +I      +H L + LE +K   ++  + +K L + +
Sbjct: 290 EESRDKVNQLEEKTKLQSENLKQSIE----KQHHLTKELEDIKVSLQRSVSTQKALEEDL 345

Query: 257 SLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSD 316
            +    I       +  E+      +       H  +V    ++ T T+   E L     
Sbjct: 346 QIATKTIC------QLTEEKETQMEESNKARAAHSFVVT---EFET-TVCSLEELLRTEQ 395

Query: 317 LFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVN 376
              E N  +++ L  +L +   E   +       + +LE  K  L E+   ++   +   
Sbjct: 396 QRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEK 455

Query: 377 AMRGLQSSKELKAELDGE-KGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIK 435
               L+ +++   EL G  + R+  +E HD E+ +  +   E  Y     EV DLK E++
Sbjct: 456 IAEELKGTEQ---ELIGLLQARE--KEVHDLEIQLTAITTSEQYYS---KEVKDLKTELE 507

Query: 436 ALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIAN 495
             K K N  + ++ + K   E+K    +    +LE   K   E + + +K+ ++M     
Sbjct: 508 NEKLK-NTELTSHCN-KLSLENKELTQETSDMTLE--LKNQQEDINNNKKQEERMLKQIE 563

Query: 496 ENHSTLNTAQDELVTFSEELAQLYHHVCL--------CNN-----ETPNRVMLDYYRQSR 542
               T    ++EL    EEL Q    V          CNN     E  N+ + +  ++++
Sbjct: 564 NLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENK 623

Query: 543 VTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISP 602
             +    KG  + + L           +  E + +   +  ES   +K+     T T   
Sbjct: 624 ALKK---KGTAESKQL-----------NVYEIKVNKLELELES---AKQKFGEITDTYQK 666

Query: 603 VITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPM 662
            I     S      ++ K          +I D+   LQK +D+  Q         E+  +
Sbjct: 667 EIEDKKISEENLLEEVEKAK--------VIADEAVKLQKEIDKRCQHK-----IAEMVAL 713

Query: 663 IDKDK---EALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAM 719
           ++K K   + ++EE      L  +K ++ ++LRA L+      +  L ++K + E E+  
Sbjct: 714 MEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIER-- 771

Query: 720 VTETMTKLRNELKALKEDAAT 740
             E   KL+ E    KE+ AT
Sbjct: 772 --EEKEKLKRE---AKENTAT 787



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 92/485 (18%), Positives = 197/485 (40%), Gaps = 57/485 (11%)

Query: 328 KLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKEL 387
           KLK+   +++  +      + + + Q+      +TE+  ++  LT  +   R   +  E 
Sbjct: 242 KLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEE 301

Query: 388 KAELDGEKGRDSGEEAHDYEVDINGLEI-----------LECKYRVAVTEVIDLKAEIKA 436
           K +L  E  + S E+ H    ++  +++           LE   ++A   +  L  E + 
Sbjct: 302 KTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKET 361

Query: 437 LKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANE 496
             E+ NK+   ++    ++E+ +   +E + + ++  +++ +++  +  ELQK +S   E
Sbjct: 362 QMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEE 421

Query: 497 NHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPR 556
                N  + EL    EEL ++     L   ET     L Y  +     +  LKG +  +
Sbjct: 422 MTKLTNNKEVEL----EELKKV-----LGEKET-----LLYENKQFEKIAEELKGTE--Q 465

Query: 557 GLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTS 616
            L+    AR      +E + ++  +       SKE    KT               L+  
Sbjct: 466 ELIGLLQAREKEVHDLEIQLTA--ITTSEQYYSKEVKDLKTE--------------LENE 509

Query: 617 DIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAA---RELAPMIDKDKEALMEE 673
            ++   +  +  N +  +  +  Q+  D +L+L  Q+      ++    + K  E L E 
Sbjct: 510 KLKNTELTSH-CNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQET 568

Query: 674 ILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKA 733
             +L++ L   RE++   R  +K     +E    NL+ + EN+   + E    L+ E KA
Sbjct: 569 ETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEE----LQQENKA 624

Query: 734 LKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQR 793
           LK+     S    ++  + ++   +L+  +++     D      T  +    +K++    
Sbjct: 625 LKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITD------TYQKEIEDKKISEENL 678

Query: 794 LEDLE 798
           LE++E
Sbjct: 679 LEEVE 683



 Score = 33.5 bits (75), Expect = 0.84
 Identities = 44/205 (21%), Positives = 98/205 (47%), Gaps = 17/205 (8%)

Query: 618 IRKEPMNIYNLNAIIRDQIKHLQKAVDRSL-QLSRQRAAARELAPMID--KDKEALMEEI 674
           ++++   I +L    + +I   +K V   L Q++ +    ++L  +++  +DK   +EE 
Sbjct: 243 LKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEK 302

Query: 675 LKLKSL-LSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKA 733
            KL+S  L    E+   L   L+  K + + +++  K   E +  + T+T+ +L  E + 
Sbjct: 303 TKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQK-ALEEDLQIATKTICQLTEEKET 361

Query: 734 LKEDAATFSSLRAMFATRCDEYVTQLDEM----QRQLAAAEDEKKTLNTLLRMAIQQKLA 789
             E++    +  +   T  +  V  L+E+    Q++L   ED+ K    +L M +Q+K +
Sbjct: 362 QMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLK----ILTMELQKKSS 417

Query: 790 ----LTQRLEDLEFDHEQSRRSKGK 810
               +T+   + E + E+ ++  G+
Sbjct: 418 ELEEMTKLTNNKEVELEELKKVLGE 442


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 169/859 (19%), Positives = 344/859 (40%), Gaps = 139/859 (16%)

Query: 7   LQTVDHYKTEIERLT-KELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQE 65
           +Q V H +  +  L   EL +   E+++A    +V+   +L    Q DE       L QE
Sbjct: 159 IQEVTHNQENVFDLQWLELPDVAPEELEALSRSMVLHLRRLI--DQRDECTELIVDLTQE 216

Query: 66  LEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLG----KILEMQNELKQSRA 121
            + L+     S  I    A+   +   +L  E     A  L     ++  ++ EL+    
Sbjct: 217 RDYLQAQHPPS-PIKSSSADSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEDKTE 275

Query: 122 VVTNVQAENERLTAVVQDLKENN---------------------------EMVELQRIRM 154
            + + + E ++L   +Q +K+ N                           E +EL+  R 
Sbjct: 276 QLVDTRHEVDQLVLELQKVKQENIQLAADARSARAYRDELDSLREKANRVERLELELTRC 335

Query: 155 KDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLN 214
           K+++ +  F +AR+     EL E+NI L +  + L++          ++   E+E + L 
Sbjct: 336 KEKLHDVDFYKARM----EELREDNIILIETKAMLEEQLTAARARGDKVHELEKENLQLK 391

Query: 215 SQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDN-HISISVDGLKFA 273
           S+L D    ++  + ++EE LE          N+  E++Q  S+N++ H+   ++ L   
Sbjct: 392 SKLHDLELDRDTDKKRIEELLE---------ENMVLEIAQKQSMNESAHLGWELEQLSKN 442

Query: 274 EDGSEPNNDD---KMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLK 330
            D S+ +      ++N      ++KL         ++ +SL        + ++  +++  
Sbjct: 443 ADLSDASRKSFVFELNECASSRILKLE--------KENQSLQSTIQGLRDASL-VLEESG 493

Query: 331 QQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAE 390
            +  ++E+E   L   +++ QTQLE  K    + ++ +  L+E +     ++  ++L+++
Sbjct: 494 LKCGELEKENHQLSKKIEKLQTQLEREK----QSNQDLETLSEEL-----IREKEQLQSD 544

Query: 391 LDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTD 450
           ++  K  D   +  D E + + L      + +     +  +A +K + EK NK++     
Sbjct: 545 METLKA-DKARQIKDLEQEKDHLN--RAMWSLRERSQVSSEARMKDV-EKENKALHQTVT 600

Query: 451 EKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVT 510
           E     S+++    Q+    +  KE GE+   +E+ELQ++     E +  L      L T
Sbjct: 601 EANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRL----QEENGRLARKVTSLET 656

Query: 511 FSEELAQLYHHVCLCNNETPN-RVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRL-ARRGV 568
            +E++  L H       E    R  LD  +   +   G  +   D + L +  L  RR V
Sbjct: 657 ATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLER---DNKQLDAENLELRRLV 713

Query: 569 SSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNL 628
            +   T T    + +E+ +  +E                         ++RK        
Sbjct: 714 ETMRFTSTKLAQMERENQQLERE-----------------------KEELRKNV------ 744

Query: 629 NAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQI 688
                D +K L K  +R L+LS Q  +A  L   + +  E+   +   L+S L     ++
Sbjct: 745 -----DLLKALGKKSER-LELSYQSVSAENL--RLQQSLESSSHKTQTLESELG----EL 792

Query: 689 ATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMF 748
              R  L+ + +   +A A L+   ++ KA+  E + +L  + K L+++A        + 
Sbjct: 793 EAERQALRRDLEALRLANAQLEGAEKDRKALEQE-VAQLEKDKKLLEKEAKRLWQQVELK 851

Query: 749 ATRCDEYVTQLDEMQRQLAAAEDE--------------KKTLNTLLRMAIQQKLALTQRL 794
               D+   +L  ++++  A + E              +K    L +        LT   
Sbjct: 852 DAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLR 911

Query: 795 EDLEFDHEQSRRSKGKLGK 813
           EDL  +  +S++   +L K
Sbjct: 912 EDLVLEKLKSQQLSSELDK 930



 Score = 66.6 bits (161), Expect = 9e-11
 Identities = 179/950 (18%), Positives = 372/950 (39%), Gaps = 153/950 (16%)

Query: 15   TEIERLTKELTETTHEKIQAAEYGLVVLEEKLT----LKQQYDELEAEYDSLKQELEQLK 70
            + I +L KE  ++    IQ      +VLEE       L+++  +L  + + L+ +LE+ K
Sbjct: 463  SRILKLEKE-NQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLEREK 521

Query: 71   EAFGQSFSIHRKVAEDGETRE---ETLLQESA------SKEAYYLGKILEMQNELKQ--S 119
            ++     ++  ++  + E  +   ETL  + A       +E  +L + +    E  Q  S
Sbjct: 522  QSNQDLETLSEELIREKEQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSS 581

Query: 120  RAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKF---REARLLQDYTELE 176
             A + +V+ EN+ L   V +       +E ++ ++  ++ + K    R  +L ++   L+
Sbjct: 582  EARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQ 641

Query: 177  EEN-------------------------------ITLQKLVSTLKQNQVEYEGLKHEIKR 205
            EEN                                TL+K + TL+   ++ EGL+ + K+
Sbjct: 642  EENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQ 701

Query: 206  FEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQ--KN-NLRKELSQYIS-LNDN 261
             + E + L  +L + +R       Q+E   + L+ E+E+  KN +L K L +    L  +
Sbjct: 702  LDAENLELR-RLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELS 760

Query: 262  HISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSEL 321
            + S+S + L+  +     ++  +    +   L +L  + +   LR+      +++   E 
Sbjct: 761  YQSVSAENLRLQQSLESSSHKTQT---LESELGELEAERQ--ALRRDLEALRLANAQLEG 815

Query: 322  NISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAM-RG 380
               + + L+Q++ Q+E++K +L    +    Q+E     L +   ++  + +   A+ + 
Sbjct: 816  AEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKE 875

Query: 381  LQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEK 440
            L   ++   +L  E  +D+ +      V    L  L     +   +   L +E+  L ++
Sbjct: 876  LARCRDAAGKLK-ELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQE 934

Query: 441  YNKSVEN----YTDEKAKYESKIQMYDEQVTSLEKTT-KESGEKMAHMEKELQKMTSIAN 495
              K   N      ++ +  ++K ++ + +  S  KTT     EK+  +E ++++  S+  
Sbjct: 935  LEKVGLNRELLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNR 994

Query: 496  ENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDP 555
            +  S L   + E  T  +   +  H          N       + +   +     GP   
Sbjct: 995  QLESELQMLKKECETLRQNQGEGQH--------LQNSFKHPAGKTAASHQGKEAWGPGHK 1046

Query: 556  RGLLS-PRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTI-SPVITAPPSSPVL 613
               +   R+  R +   +E   ++    K+  +   +   T+  T  S ++T    S  L
Sbjct: 1047 EATMELLRVKDRAIE--LERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFL 1104

Query: 614  ---------DTSDIRKEPMNIYNLNAIIRDQIKHLQ------KAVDRSLQLSRQRAAARE 658
                      T+ ++ E   + + +A +  Q   LQ      +  + SLQ  +++  A  
Sbjct: 1105 QEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAY 1164

Query: 659  LAPMIDKDK------------EALMEEILKLKSL------------------------LS 682
             A + D +             EAL+ +   LK+L                        L 
Sbjct: 1165 EALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDMLKRKAELE 1224

Query: 683  TKREQIATLRAVLKANKQTAEVALA-----------------NLKNKYENEKAMVTETMT 725
             + + + T R  L+  ++T  +A+                   LK +YE   A   E  T
Sbjct: 1225 EREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHTKELKT 1284

Query: 726  KLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDE----MQRQLAAAEDEKKTLNTLLR 781
             L N    L    A F  L+    T  D  +T+LD     + R     E+E   L + ++
Sbjct: 1285 SLNNAQLELNRWQARFDELKEQHQT-MDISLTKLDNHCELLSRLKGNLEEENHHLLSQIQ 1343

Query: 782  MAIQQ-KLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKIVSSLLPPYR 830
            +  QQ ++ L Q +E+ E  HE+ ++   KL   +    K+   ++  Y+
Sbjct: 1344 LLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMDQYK 1393



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 108/527 (20%), Positives = 213/527 (40%), Gaps = 57/527 (10%)

Query: 5    EVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQ 64
            + LQ V      +ER  K+L     E  +  E       +   ++++  +LE E + L++
Sbjct: 683  DTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRK 742

Query: 65   ELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVT 124
             ++ LK A G+            ++    L  +S S E       L +Q  L+ S     
Sbjct: 743  NVDLLK-ALGK------------KSERLELSYQSVSAEN------LRLQQSLESSSHKTQ 783

Query: 125  NVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQK 184
             +++E   L A  Q L+ + E + L   +++   ++ K  E    Q+  +LE++   L+K
Sbjct: 784  TLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALE----QEVAQLEKDKKLLEK 839

Query: 185  LVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRL-KEIAEHQLEEALETLKNERE 243
                L Q QVE   LK  +   ++ T  L++  +++  L KE+A  +  +A   LK   +
Sbjct: 840  EAKRLWQ-QVE---LKDAV--LDDSTAKLSAVEKESRALDKELA--RCRDAAGKLKELEK 891

Query: 244  QKNNLRKELSQYI-SLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRT 302
               +L K+++ +  +L      + ++ LK  +  SE    DK++  +    V LN   R 
Sbjct: 892  DNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSEL---DKLSQELE--KVGLN---RE 943

Query: 303  PTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALT 362
              L++ +S +     +  L       LK  L   E +  +L A ++E  +     +  L 
Sbjct: 944  LLLQEDDSGSDTK--YKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQ 1001

Query: 363  EQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRV 422
               +    L ++    + LQ+S   K           G+EA         +E+L  K R 
Sbjct: 1002 MLKKECETLRQNQGEGQHLQNS--FKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDR- 1058

Query: 423  AVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAH 482
               E+    A ++A K+   + +++   +   + S+I    +Q   L++       + A 
Sbjct: 1059 -AIELERNNAALQAEKQLLKEQLQHLETQNVTFSSQILTLQKQSAFLQEHNTTLQTQTAK 1117

Query: 483  MEKELQKMTS----------IANENHSTLNTAQDELVTFSEELAQLY 519
            ++ E   ++S          +   +H+   T  + L    E+L   Y
Sbjct: 1118 LQVENSTLSSQSAALTAQYTLLQNHHTAKETENESLQRQQEQLTAAY 1164



 Score = 37.7 bits (86), Expect = 0.044
 Identities = 41/203 (20%), Positives = 84/203 (41%), Gaps = 21/203 (10%)

Query: 14   KTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYD-------ELEAEYDSLKQEL 66
            K E+E   K LT       Q      + + E   L+ + D       +L+ EY+ L    
Sbjct: 1220 KAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQLKGEYEELHAHT 1279

Query: 67   EQLKEAFGQS-FSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTN 125
            ++LK +   +   ++R  A   E +E+    + +         + ++ N  +    +  N
Sbjct: 1280 KELKTSLNNAQLELNRWQARFDELKEQHQTMDIS---------LTKLDNHCELLSRLKGN 1330

Query: 126  VQAENERLTAVVQDLKENNEMVELQRIRMK----DEIREYKFREARLLQDYTELEEENIT 181
            ++ EN  L + +Q L + N+M+  Q +  K    +E ++Y  +   L +   +LEE+ + 
Sbjct: 1331 LEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEKIMD 1390

Query: 182  LQKLVSTLKQNQVEYEGLKHEIK 204
              K      + +  + G K  +K
Sbjct: 1391 QYKFYDPPPKKKNHWIGAKALVK 1413


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 77.4 bits (189), Expect = 5e-14
 Identities = 129/668 (19%), Positives = 266/668 (39%), Gaps = 86/668 (12%)

Query: 183  QKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNER 242
            +K ++T+K+   E++  K E+ + E +   L  +L   ++ K   + Q++   E L +  
Sbjct: 847  EKEMATMKE---EFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAE 903

Query: 243  EQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRT 302
            E+ + L K   Q  +             K  E      +++++N  +     KL  +   
Sbjct: 904  ERCDQLIKAKFQLEA-------------KIKEVTERAEDEEEINAELTAKKRKLEDEC-- 948

Query: 303  PTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALT 362
                  E    + DL  EL +++++K K       +     L+ L E+  +L   K AL 
Sbjct: 949  -----SELKKDIDDL--ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQ 1001

Query: 363  EQHER-VHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDIN-GLEILECKY 420
            E H++ +  L    + +  L  +K  K E   E    S E+     VD+      LE   
Sbjct: 1002 EAHQQALDDLQAEEDKVNSLNKTKS-KLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDL 1060

Query: 421  RVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLE--KTTKESGE 478
            ++A   ++DL+ + + L E+  K    Y   ++K E      DEQ   L+  K  KE   
Sbjct: 1061 KLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVE------DEQTLGLQFQKKIKELQA 1114

Query: 479  KMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYY 538
            ++  +E+E++          +T    + +   ++ EL +L   +      T  ++ L+  
Sbjct: 1115 RIEELEEEIEA-------ERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKK 1167

Query: 539  RQSRVTR-SGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKT 597
            R++   +    L+        +   L ++   S  E     + + +   +  KE S  K 
Sbjct: 1168 REAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKL 1227

Query: 598  PTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQ---KAVDRSL------- 647
              I  + ++  S        + K   N+  +   + DQ+   +   + + RSL       
Sbjct: 1228 E-IDDLSSSMES--------VSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQK 1278

Query: 648  --------QLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANK 699
                    +LSRQ      +   + + K+A  ++  +LK  L  + +    L   L++++
Sbjct: 1279 SRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSR 1338

Query: 700  QTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQL 759
               ++    L+ +YE E+    E   +L+  L     + A +   R  + T   +   +L
Sbjct: 1339 HDCDL----LREQYEEEQ----EGKAELQRALSKANSEVAQW---RTKYETDAIQRTEEL 1387

Query: 760  DEMQRQLAA----AEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSK 815
            +E +++LA     +E++ + +N       + K  L   +EDL  D E++      L K +
Sbjct: 1388 EEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQ 1447

Query: 816  IGSPKIVS 823
                K+++
Sbjct: 1448 RNFDKVLA 1455



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 155/845 (18%), Positives = 343/845 (40%), Gaps = 93/845 (11%)

Query: 30   EKIQAAEYGLVVLEEKLTLKQQYD-ELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGE 88
            +KI+  +  +  LEE++  ++    + E +     +ELE+L E   ++  +     E  +
Sbjct: 1107 KKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNK 1166

Query: 89   TRE-----------ETLLQESASKEAY---YLGKILEMQNELKQSRAVVTNVQAENERLT 134
             RE           E  LQ  A   A    +   + E+  ++   + V   ++ E     
Sbjct: 1167 KREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1226

Query: 135  AVVQDLKENNEMVE-----LQRI--RMKDEIREYKFREARLLQDYTELEEENITLQKLVS 187
              + DL  + E V      L++I   ++D++ E + +   + +  +EL  +   LQ    
Sbjct: 1227 LEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG 1286

Query: 188  TLKQNQVEYEGLKHEIKR----FEEETVLLNSQLEDAIRLKEIAEHQLEEA---LETLKN 240
             L +   E E +  ++ R    F ++T  L  QLE+  + K    H L+ +    + L+ 
Sbjct: 1287 ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLRE 1346

Query: 241  EREQKNNLRKELSQYISLNDNHIS-----ISVDGLKFAEDGSEPNND-----DKMNGHIH 290
            + E++   + EL + +S  ++ ++        D ++  E+  E               + 
Sbjct: 1347 QYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVE 1406

Query: 291  GPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLAN---- 346
                K     +T    +GE    V DL   +++     L   L + +R    +LA     
Sbjct: 1407 AVNAKCASLEKTKQRLQGE----VEDLM--VDVERANSLAAALDKKQRNFDKVLAEWKTK 1460

Query: 347  LQESQTQLE----HTKGALTEQHERVHRLTEHVNAMRGLQ-SSKELKAELDG--EKGRDS 399
             +ESQ +LE     ++   TE  +  +   E ++ +  ++  +K L+ E+    E+  ++
Sbjct: 1461 CEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAEN 1520

Query: 400  GEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKI 459
            G+  H+ E     +E+ +   ++A+ E    +A ++  + K  +     T  K++ + KI
Sbjct: 1521 GKTIHELEKSRKQIELEKADIQLALEEA---EAALEHEEAKILRIQLELTQVKSEIDRKI 1577

Query: 460  QMYDEQVTSLEKTTKESGEKM-AHMEKELQKMTS---IANENHSTLNTAQDELVTFSEEL 515
               DE++  L++  + + E M + ++ E++       +  +    LN  + +L   + + 
Sbjct: 1578 AEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQA 1637

Query: 516  AQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLS--PRLARRGVSSPVE 573
            A+   H+         R +    + +++    +L+G +D +  L+   R A    +   E
Sbjct: 1638 AETLKHL---------RSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEE 1688

Query: 574  TRTSSEPVAKESTEASKE--PSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAI 631
             R + E   +    A +E   S  +   +    T+   +     +D+ +    + + +  
Sbjct: 1689 LRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRD 1748

Query: 632  IRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATL 691
             R+  +  +KA+  +  ++ +    ++ +  +++ K+ L + +  L+  L  + EQ+A  
Sbjct: 1749 ARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLD-EAEQLA-- 1805

Query: 692  RAVLKANK---QTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLR--- 745
               LK  K   Q  E  +  L+ + E E+   TE++  LR   + +KE   T+ S     
Sbjct: 1806 ---LKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKE--LTYQSEEDRK 1860

Query: 746  --AMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQ 803
                     D+   ++   +RQ   A+++     T  R A Q +L   +   D+      
Sbjct: 1861 NVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKA-QHELEEAEERADIAESQVN 1919

Query: 804  SRRSK 808
              R+K
Sbjct: 1920 KLRAK 1924



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 159/829 (19%), Positives = 330/829 (39%), Gaps = 126/829 (15%)

Query: 14   KTEIERLT-KELTETTHEKIQAAEYGLVVLEEKL-TLKQQYDELEAEYDSLKQELEQLKE 71
            +TE E  T KE  + T +++  +E     LEEKL TL Q+ ++L+ +  +  + L     
Sbjct: 845  ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLL---- 900

Query: 72   AFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENE 131
                          D E R + L++     EA    KI E+    +    +   + A+  
Sbjct: 901  --------------DAEERCDQLIKAKFQLEA----KIKEVTERAEDEEEINAELTAKKR 942

Query: 132  RLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQ 191
            +L     +LK++ + +EL   +++ E    + +   L ++ + L+E   T+ KL    K 
Sbjct: 943  KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDE---TIAKLTREKKA 999

Query: 192  NQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKE 251
             Q  ++    +++  E++   LN             + +LE+ +E L++  EQ+  LR +
Sbjct: 1000 LQEAHQQALDDLQAEEDKVNSLNK-----------TKSKLEQQVEDLESSLEQEKKLRVD 1048

Query: 252  LSQYISLNDNHISISVDG-LKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGES 310
            L +     +  + ++ +  L    D  + +   K     +  L     D +T  L+  + 
Sbjct: 1049 LERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKK 1108

Query: 311  LNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHR 370
            +  +     EL   EI+  +    + E++++     L+E   +LE   G  + Q      
Sbjct: 1109 IKELQARIEELE-EEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQ------ 1161

Query: 371  LTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDL 430
                      ++ +K+ +AE   +  RD  E    +E  +     L  K+  +V E+ + 
Sbjct: 1162 ----------IELNKKREAEF-LKLRRDLEEATLQHEAMV---AALRKKHADSVAELGEQ 1207

Query: 431  KAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAH---MEKEL 487
               ++ +K+K  K    +  E     S ++   +   +LEK  +   ++++      +E+
Sbjct: 1208 IDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEI 1267

Query: 488  QKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSG 547
            Q+  S      S L T   EL    EE   +                L   +Q+   ++ 
Sbjct: 1268 QRSLSELTTQKSRLQTEAGELSRQLEEKESIVS-------------QLSRSKQAFTQQTE 1314

Query: 548  SLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAP 607
             LK     R L     A+  ++  +++      + +E  E  +E        +S   +  
Sbjct: 1315 ELK-----RQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANS-- 1367

Query: 608  PSSPVLDTSDIRKEPMNIYNLNAIIR-DQIKHLQKAVDRSLQLSRQRA-AARELAPMIDK 665
                  + +  R +    Y  +AI R ++++  +K + + LQ S ++  A       ++K
Sbjct: 1368 ------EVAQWRTK----YETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEK 1417

Query: 666  DKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMT 725
             K+ L  E+      L    E+  +L A L   ++  +  LA  K K E  +A       
Sbjct: 1418 TKQRLQGEV----EDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQA------- 1466

Query: 726  KLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDE-----------KK 774
                EL+A  +++ + S+         +E + QL+ ++R+    E E            K
Sbjct: 1467 ----ELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGK 1522

Query: 775  TLNTLLRMAIQ---QKLALTQRLEDLE--FDHEQSRRSKGKLGKSKIGS 818
            T++ L +   Q   +K  +   LE+ E   +HE+++  + +L  +++ S
Sbjct: 1523 TIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKS 1571



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 88/408 (21%), Positives = 166/408 (40%), Gaps = 57/408 (13%)

Query: 1    MAAEEVLQTVDHYKTEIERLTKELTETTHE---KIQAAEYGLVVLEEKL--TLKQQYDEL 55
            +A EE    ++H + +I R+  ELT+   E   KI   +  +  L+     T++     L
Sbjct: 1543 LALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSAL 1602

Query: 56   EAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETL-----LQESASKEAYYLGKIL 110
            +AE  S  + +   K+  G    I  +++       ETL     +Q        +L   L
Sbjct: 1603 DAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDAL 1662

Query: 111  EMQNELKQSRAVVTN----VQAENERLTAVV-----------QDLKENNEMVELQRIRMK 155
              Q +LK+  A+V      +QAE E L A +           Q+L ++NE V+L   +  
Sbjct: 1663 RGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNT 1722

Query: 156  DEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNS 215
              I   K  E  L+Q  +E+E+ +   +      K+   +   +  E+K+ ++ +  L  
Sbjct: 1723 SLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1782

Query: 216  QLEDAIRLKEIAEHQLEEALE-TLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAE 274
              ++  +  +  +H+L+EA +  LK  ++Q   L   + +               L+F  
Sbjct: 1783 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRE---------------LEFEL 1827

Query: 275  DGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPV---SDLFSELNISEIQKLKQ 331
            +G +  N + + G     L K     +  T +  E    V    DL  +L + +++  K+
Sbjct: 1828 EGEQKKNTESVKG-----LRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQV-KVKSYKR 1881

Query: 332  QLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMR 379
            Q  + + +    L   +++Q +LE       E  ER       VN +R
Sbjct: 1882 QAEEADEQANAHLTKFRKAQHELE-------EAEERADIAESQVNKLR 1922



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 99/510 (19%), Positives = 206/510 (40%), Gaps = 66/510 (12%)

Query: 13   YKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEA 72
            +KT+ E    EL  +  E    +        E   LK  Y+E   + +++K+E + L++ 
Sbjct: 1457 WKTKCEESQAELEASLKESRSLST-------ELFKLKNAYEEALDQLETVKRENKNLEQE 1509

Query: 73   FGQSFSIHRKVAEDGETREET----------------LLQESASKEAYYLGKILEMQNEL 116
                  +  ++AE+G+T  E                  L+E+ +   +   KIL +Q EL
Sbjct: 1510 IAD---LTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLEL 1566

Query: 117  KQSRAVVTNVQAENERLTAVVQDLKEN-NEMVELQRIRMKDEIREYKFREARLLQDYTEL 175
             Q ++ +    AE +     ++ LK N    VE  +  +  E+R     EA  L+   E 
Sbjct: 1567 TQVKSEIDRKIAEKDE---EIEQLKRNYQRTVETMQSALDAEVRSR--NEAIRLKKKMEG 1621

Query: 176  EEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQ----- 230
            +   I +Q        N+   E LKH ++  + +       L+DA+R +E  + Q     
Sbjct: 1622 DLNEIEIQ----LSHANRQAAETLKH-LRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVE 1676

Query: 231  -----LEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKM 285
                 L+  +E L+   EQ    RK   Q +  ++  +      L   ++ S  +   K+
Sbjct: 1677 RRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQ-----LLHTQNTSLIHTKKKL 1731

Query: 286  NGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLA 345
               +     ++    R     + ++   ++D  + +   E++K +     +ER K  L  
Sbjct: 1732 ETDLMQLQSEVEDASRDARNAEEKAKKAITD--AAMMAEELKKEQDTSAHLERMKKNLEQ 1789

Query: 346  NLQESQTQLEHTKG-ALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGE--KGRDSGEE 402
             +++ Q +L+  +  AL    +++ +L   +         +EL+ EL+GE  K  +S + 
Sbjct: 1790 TVKDLQHRLDEAEQLALKGGKKQIQKLETRI---------RELEFELEGEQKKNTESVKG 1840

Query: 403  AHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMY 462
               YE  +  L     + R  V  + DL  +++   + Y +  E   ++   + +K +  
Sbjct: 1841 LRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKA 1900

Query: 463  DEQVTSLEKTTKESGEKMAHMEKELQKMTS 492
              ++   E+    +  ++  +  + +  TS
Sbjct: 1901 QHELEEAEERADIAESQVNKLRAKTRDFTS 1930



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 110/512 (21%), Positives = 203/512 (39%), Gaps = 75/512 (14%)

Query: 335  QVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGE 394
            + E+E A +    Q+++ +L  ++    E  E++  L +  N ++ LQ   E +  LD E
Sbjct: 845  ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQ-LQVQAESENLLDAE 903

Query: 395  ---------------KGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKE 439
                           K ++  E A D E +IN    L  K R    E  +LK +I  L+ 
Sbjct: 904  ERCDQLIKAKFQLEAKIKEVTERAEDEE-EINAE--LTAKKRKLEDECSELKKDIDDLEL 960

Query: 440  KYNKSVENYTDEKAKYESKIQMYDEQVTSLEKT-TKESGEKMAHMEKELQKMTSIANENH 498
               K VE    EK   E+K++   E+++ L++T  K + EK A  E   Q +  +  E  
Sbjct: 961  TLAK-VEK---EKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEED 1016

Query: 499  --STLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPR 556
              ++LN  + +L    E+L          + E   ++ +D  R  R    G LK      
Sbjct: 1017 KVNSLNKTKSKLEQQVEDLES--------SLEQEKKLRVDLERNKRKLE-GDLK------ 1061

Query: 557  GLLSPRLARRGVSSPVETRTS-SEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDT 615
                  LA+  +      +    E + K+  E  +  S  +                L  
Sbjct: 1062 ------LAQESILDLENDKQQLDERLKKKDFEYCQLQSKVE------------DEQTLGL 1103

Query: 616  SDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAA-ARELAPMIDKDKEALMEEI 674
               +K    I  L A I +  + ++       +  +QR+  AREL  + ++ +EA    +
Sbjct: 1104 QFQKK----IKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEA--GGV 1157

Query: 675  LKLKSLLSTKRE-QIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKA 733
               +  L+ KRE +   LR  L+      E  +A L+ K+ +  A + E +  L+   + 
Sbjct: 1158 TSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQK 1217

Query: 734  LKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQR 793
            L+++       ++ F    D+  + ++ + +  A  E   +TL   L  A  +   + + 
Sbjct: 1218 LEKE-------KSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRS 1270

Query: 794  LEDLEFDHEQSRRSKGKLGKSKIGSPKIVSSL 825
            L +L     + +   G+L +       IVS L
Sbjct: 1271 LSELTTQKSRLQTEAGELSRQLEEKESIVSQL 1302


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.126    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,286,246
Number of Sequences: 37866
Number of extensions: 1244016
Number of successful extensions: 16097
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 267
Number of HSP's successfully gapped in prelim test: 1012
Number of HSP's that attempted gapping in prelim test: 7946
Number of HSP's gapped (non-prelim): 5618
length of query: 835
length of database: 18,247,518
effective HSP length: 111
effective length of query: 724
effective length of database: 14,044,392
effective search space: 10168139808
effective search space used: 10168139808
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.