Search of human proteins with 50897856

Search of human proteins with 50897856

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|50897856 hypothetical protein LOC220965 isoform 1 [Homo
sapiens]
         (585 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|50897856 hypothetical protein LOC220965 isoform 1 [Homo sapiens]  1183   0.0  
gi|219555642 hypothetical protein LOC220965 isoform 3 [Homo sapi...  1011   0.0  
gi|50897854 hypothetical protein LOC220965 isoform 2 [Homo sapiens]   646   0.0  
gi|56119110 family with sequence similarity 13, member A1 isofor...   287   2e-77
gi|62865869 family with sequence similarity 13, member A1 isofor...   287   2e-77
gi|156142190 hypothetical protein LOC51306 isoform 2 [Homo sapiens]   243   3e-64
gi|156142192 hypothetical protein LOC51306 isoform 3 [Homo sapiens]   242   6e-64
gi|156142188 hypothetical protein LOC51306 isoform 1 [Homo sapiens]   228   9e-60
gi|150170670 piccolo isoform 2 [Homo sapiens]                          45   2e-04
gi|150378539 piccolo isoform 1 [Homo sapiens]                          45   2e-04
gi|54112380 F-box and leucine-rich repeat protein 10 isoform b [...    42   0.002
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                 41   0.003
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        40   0.008
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ...    39   0.013
gi|238624188 diffuse panbronchiolitis critical region 1 protein ...    39   0.017
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    39   0.017
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]         38   0.023
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H...    38   0.023
gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [H...    38   0.023
gi|118442841 hypothetical protein LOC123591 [Homo sapiens]             38   0.023
gi|239740773 PREDICTED: similar to diffuse panbronchiolitis crit...    38   0.030
gi|151101151 coiled-coil domain containing 2 isoform b [Homo sap...    38   0.030
gi|151101140 coiled-coil domain containing 2 isoform a [Homo sap...    38   0.030
gi|151105223 coiled-coil domain containing 2 isoform a [Homo sap...    38   0.030
gi|151105229 coiled-coil domain containing 2 isoform a [Homo sap...    38   0.030
gi|58530842 desmoplakin isoform II [Homo sapiens]                      37   0.050
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu...    37   0.050
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre...    37   0.050
gi|169214011 PREDICTED: hypothetical protein [Homo sapiens]            37   0.050
gi|113428768 PREDICTED: hypothetical protein [Homo sapiens]            37   0.050

>gi|50897856 hypothetical protein LOC220965 isoform 1 [Homo sapiens]
          Length = 585

 Score = 1183 bits (3060), Expect = 0.0
 Identities = 585/585 (100%), Positives = 585/585 (100%)

Query: 1   MFSCFCFSLQDNSFSSTTVTECDEDPVSLHEDQTDCSSLRDENNKENYPDAGALVEEHAP 60
           MFSCFCFSLQDNSFSSTTVTECDEDPVSLHEDQTDCSSLRDENNKENYPDAGALVEEHAP
Sbjct: 1   MFSCFCFSLQDNSFSSTTVTECDEDPVSLHEDQTDCSSLRDENNKENYPDAGALVEEHAP 60

Query: 61  PSWEPQQQNVEATVLVDSVLRPSMGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSEC 120
           PSWEPQQQNVEATVLVDSVLRPSMGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSEC
Sbjct: 61  PSWEPQQQNVEATVLVDSVLRPSMGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSEC 120

Query: 121 QVRAGTPAHESPQNNAFKCQETVRLQPRIDQRTAISPKDAFETRQDLNEEEAAQVHGVKD 180
           QVRAGTPAHESPQNNAFKCQETVRLQPRIDQRTAISPKDAFETRQDLNEEEAAQVHGVKD
Sbjct: 121 QVRAGTPAHESPQNNAFKCQETVRLQPRIDQRTAISPKDAFETRQDLNEEEAAQVHGVKD 180

Query: 181 PAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPR 240
           PAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPR
Sbjct: 181 PAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPR 240

Query: 241 CSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKI 300
           CSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKI
Sbjct: 241 CSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKI 300

Query: 301 RKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPR 360
           RKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPR
Sbjct: 301 RKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPR 360

Query: 361 NLLCEQPTVPRENGKPEAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKNL 420
           NLLCEQPTVPRENGKPEAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKNL
Sbjct: 361 NLLCEQPTVPRENGKPEAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKNL 420

Query: 421 IKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSN 480
           IKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSN
Sbjct: 421 IKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSN 480

Query: 481 ETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETRADKKRLRKALREFEEQFF 540
           ETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETRADKKRLRKALREFEEQFF
Sbjct: 481 ETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETRADKKRLRKALREFEEQFF 540

Query: 541 KQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQDVAKTI 585
           KQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQDVAKTI
Sbjct: 541 KQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQDVAKTI 585


>gi|219555642 hypothetical protein LOC220965 isoform 3 [Homo
           sapiens]
          Length = 502

 Score = 1011 bits (2613), Expect = 0.0
 Identities = 502/502 (100%), Positives = 502/502 (100%)

Query: 84  MGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSECQVRAGTPAHESPQNNAFKCQETV 143
           MGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSECQVRAGTPAHESPQNNAFKCQETV
Sbjct: 1   MGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSECQVRAGTPAHESPQNNAFKCQETV 60

Query: 144 RLQPRIDQRTAISPKDAFETRQDLNEEEAAQVHGVKDPAPASTQSVLADGTDSADPSPVH 203
           RLQPRIDQRTAISPKDAFETRQDLNEEEAAQVHGVKDPAPASTQSVLADGTDSADPSPVH
Sbjct: 61  RLQPRIDQRTAISPKDAFETRQDLNEEEAAQVHGVKDPAPASTQSVLADGTDSADPSPVH 120

Query: 204 KDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPRCSIFSQSQRFNLDPESAPSPPST 263
           KDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPRCSIFSQSQRFNLDPESAPSPPST
Sbjct: 121 KDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPRCSIFSQSQRFNLDPESAPSPPST 180

Query: 264 QQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSN 323
           QQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSN
Sbjct: 181 QQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSN 240

Query: 324 PEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPRNLLCEQPTVPRENGKPEAAGPEP 383
           PEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPRNLLCEQPTVPRENGKPEAAGPEP
Sbjct: 241 PEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPRNLLCEQPTVPRENGKPEAAGPEP 300

Query: 384 SSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKNLIKPLYDRYRIIKQILSTPSLIPT 443
           SSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKNLIKPLYDRYRIIKQILSTPSLIPT
Sbjct: 301 SSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKNLIKPLYDRYRIIKQILSTPSLIPT 360

Query: 444 IQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSNETEPVRALLPDEKKEVKPPALSM 503
           IQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSNETEPVRALLPDEKKEVKPPALSM
Sbjct: 361 IQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSNETEPVRALLPDEKKEVKPPALSM 420

Query: 504 SNLHEATMPVLLDHLRETRADKKRLRKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYK 563
           SNLHEATMPVLLDHLRETRADKKRLRKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYK
Sbjct: 421 SNLHEATMPVLLDHLRETRADKKRLRKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYK 480

Query: 564 HIKAKLRLLEVLISKQDVAKTI 585
           HIKAKLRLLEVLISKQDVAKTI
Sbjct: 481 HIKAKLRLLEVLISKQDVAKTI 502


>gi|50897854 hypothetical protein LOC220965 isoform 2 [Homo sapiens]
          Length = 487

 Score =  646 bits (1667), Expect = 0.0
 Identities = 337/410 (82%), Positives = 353/410 (86%), Gaps = 12/410 (2%)

Query: 1   MFSCFCFSLQDNSFSSTTVTECDEDPVSLHEDQTDCSSLRDENNKENYPDAGALVEEHAP 60
           MFSCFCFSLQDNSFSSTTVTECDEDPVSLHEDQTDCSSLRDENNKENYPDAGALVEEHAP
Sbjct: 1   MFSCFCFSLQDNSFSSTTVTECDEDPVSLHEDQTDCSSLRDENNKENYPDAGALVEEHAP 60

Query: 61  PSWEPQQQNVEATVLVDSVLRPSMGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSEC 120
           PSWEPQQQNVEATVLVDSVLRPSMGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSEC
Sbjct: 61  PSWEPQQQNVEATVLVDSVLRPSMGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSEC 120

Query: 121 QVRAGTPAHESPQNNAFKCQETVRLQPRIDQRTAISPKDAFETRQDLNEEEAAQVHGVKD 180
           QVRAGTPAHESPQNNAFKCQETVRLQPRIDQRTAISPKDAFETRQDLNEEEAAQVHGVKD
Sbjct: 121 QVRAGTPAHESPQNNAFKCQETVRLQPRIDQRTAISPKDAFETRQDLNEEEAAQVHGVKD 180

Query: 181 PAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPR 240
           PAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPR
Sbjct: 181 PAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPR 240

Query: 241 CSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKI 300
           CSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKI
Sbjct: 241 CSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKI 300

Query: 301 RKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQL---KELKLKLSEEQGSAPKG 357
           RKFEEKFEQEKKYR +  DK     ++K + D  +  KQ+     L   + EE+ S    
Sbjct: 301 RKFEEKFEQEKKYRVTKQDK----NLIKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDR 356

Query: 358 PPRNLLCEQPTVPRENGKPEAAGPEPSSSGEETPDAALTCLKERREQLPP 407
           P  +   +QP++  +       G   + S E  P  AL    E++E  PP
Sbjct: 357 PQGS---QQPSL-ADPASHLPVGDHLTYSNETEPVRAL-LPDEKKEVKPP 401



 Score =  351 bits (900), Expect = 1e-96
 Identities = 185/234 (79%), Positives = 197/234 (84%), Gaps = 3/234 (1%)

Query: 355 PKGPPRNLLCEQPTVPRENGKPEAA-GPEPSSSGEETPDAALTCLKERR--EQLPPQEDS 411
           P+  P     +Q  +PR + +     G EP +  + T        K R+  E+   ++  
Sbjct: 254 PESAPSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKY 313

Query: 412 KVTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLP 471
           +VTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLP
Sbjct: 314 RVTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLP 373

Query: 472 VGDHLTYSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETRADKKRLRKA 531
           VGDHLTYSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETRADKKRLRKA
Sbjct: 374 VGDHLTYSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETRADKKRLRKA 433

Query: 532 LREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQDVAKTI 585
           LREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQDVAKTI
Sbjct: 434 LREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQDVAKTI 487


>gi|56119110 family with sequence similarity 13, member A1 isoform a
            [Homo sapiens]
          Length = 1023

 Score =  287 bits (734), Expect = 2e-77
 Identities = 185/478 (38%), Positives = 255/478 (53%), Gaps = 59/478 (12%)

Query: 162  ETRQDLNEEEAAQVHGVKDPAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVG 221
            +T+Q  N++   Q        P S  + L D  +  +P P     Q E   + E   S  
Sbjct: 540  DTKQQRNQDAGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQ 599

Query: 222  TSRLLYHITDGDN-PLLSPRCSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDG 280
              RL+  + D D+ P+LSPR   + QS+++  D E  PSPP++  FM  RSSS  S  D 
Sbjct: 600  AGRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDE 659

Query: 281  KEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQL 340
            +E  T  QLT+ IQSLK+KIRKFE++FE+EKKYRPSH DK +NPEVLKW NDLAK R+QL
Sbjct: 660  QEDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKFRRQL 719

Query: 341  KELKLKLSEEQGSAPKGPPRNLLCE---QPTVPRENGKPEAAGPEPSSSGEETPDAALTC 397
            KE KLK+SEE  +       N L +         +  K E        S E T ++    
Sbjct: 720  KESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRK 779

Query: 398  LKERREQLPPQEDSK----------------------------VTKQDKNLIKPLYDRYR 429
            L+E+R +    ED K                            VTK ++ ++KPLYDRYR
Sbjct: 780  LQEKRAESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKNERQVMKPLYDRYR 839

Query: 430  IIKQILS----------------TPSLIPTIQEEEDS----DEDRPQGSQQPSLADPASH 469
            ++KQILS                +P L P I+ E  S     ++  +GS+  S   P   
Sbjct: 840  LVKQILSRANTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDSNVKPDFM 899

Query: 470  LPVGDHLT-------YSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETR 522
            + +    +       + ++ +   + + D+          +SNLH A++P LL+HL+E R
Sbjct: 900  VTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMR 959

Query: 523  ADKKRLRKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQD 580
             +KKR+RK LR+FE+ FF+Q GR+ QKEDR PMA+EY EYKHIKAKLRLLEVLISK+D
Sbjct: 960  EEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYSEYKHIKAKLRLLEVLISKRD 1017



 Score = 29.6 bits (65), Expect = 8.0
 Identities = 51/240 (21%), Positives = 89/240 (37%), Gaps = 49/240 (20%)

Query: 322 SNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKG--PPRNLLCEQPTVP-RENGKPEA 378
           + P+  +WM+D  KG           +E+ G   +    P   + E P++   +  + + 
Sbjct: 500 TGPDDFEWMSDERKG-----------NEKDGGHTQHFESPTMKIQEHPSLSDTKQQRNQD 548

Query: 379 AGPEPSSSGEETPDAALTCL---KERREQLPPQEDSKVTKQDKNLIKPLYDRYRIIKQIL 435
           AG +  S   E P + LT L   K   E +P     +    D +         R+I+Q+L
Sbjct: 549 AGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQAGRLIRQLL 608

Query: 436 ---STPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSNETEPVRALLPDE 492
              S P L P       S +        PS   P SH       ++            DE
Sbjct: 609 DEDSDPMLSPRFYAYGQSRQYLDDTEVPPS--PPNSH-------SFMRRRSSSLGSYDDE 659

Query: 493 KKEVKPPALSMSNLHEATMPVLLDHLRETRADKKRLRKALREFEEQFFKQTGRSPQKEDR 552
           ++++ P  L+                R  ++ KK++RK    FE++F ++    P   D+
Sbjct: 660 QEDLTPAQLT----------------RRIQSLKKKIRK----FEDRFEEEKKYRPSHSDK 699


>gi|62865869 family with sequence similarity 13, member A1 isoform b
           [Homo sapiens]
          Length = 697

 Score =  287 bits (734), Expect = 2e-77
 Identities = 185/478 (38%), Positives = 255/478 (53%), Gaps = 59/478 (12%)

Query: 162 ETRQDLNEEEAAQVHGVKDPAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVG 221
           +T+Q  N++   Q        P S  + L D  +  +P P     Q E   + E   S  
Sbjct: 214 DTKQQRNQDAGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQ 273

Query: 222 TSRLLYHITDGDN-PLLSPRCSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDG 280
             RL+  + D D+ P+LSPR   + QS+++  D E  PSPP++  FM  RSSS  S  D 
Sbjct: 274 AGRLIRQLLDEDSDPMLSPRFYAYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDE 333

Query: 281 KEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQL 340
           +E  T  QLT+ IQSLK+KIRKFE++FE+EKKYRPSH DK +NPEVLKW NDLAK R+QL
Sbjct: 334 QEDLTPAQLTRRIQSLKKKIRKFEDRFEEEKKYRPSHSDKAANPEVLKWTNDLAKFRRQL 393

Query: 341 KELKLKLSEEQGSAPKGPPRNLLCE---QPTVPRENGKPEAAGPEPSSSGEETPDAALTC 397
           KE KLK+SEE  +       N L +         +  K E        S E T ++    
Sbjct: 394 KESKLKISEEDLTPRMRQRSNTLPKSFGSQLEKEDEKKQELVDKAIKPSVEATLESIQRK 453

Query: 398 LKERREQLPPQEDSK----------------------------VTKQDKNLIKPLYDRYR 429
           L+E+R +    ED K                            VTK ++ ++KPLYDRYR
Sbjct: 454 LQEKRAESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKNERQVMKPLYDRYR 513

Query: 430 IIKQILS----------------TPSLIPTIQEEEDS----DEDRPQGSQQPSLADPASH 469
           ++KQILS                +P L P I+ E  S     ++  +GS+  S   P   
Sbjct: 514 LVKQILSRANTIPIIGSPSSKRRSPLLQPIIEGETASFFKEIKEEEEGSEDDSNVKPDFM 573

Query: 470 LPVGDHLT-------YSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETR 522
           + +    +       + ++ +   + + D+          +SNLH A++P LL+HL+E R
Sbjct: 574 VTLKTDFSARCFLDQFEDDADGFISPMDDKIPSKCSQDTGLSNLHAASIPELLEHLQEMR 633

Query: 523 ADKKRLRKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQD 580
            +KKR+RK LR+FE+ FF+Q GR+ QKEDR PMA+EY EYKHIKAKLRLLEVLISK+D
Sbjct: 634 EEKKRIRKKLRDFEDNFFRQNGRNVQKEDRTPMAEEYSEYKHIKAKLRLLEVLISKRD 691



 Score = 29.6 bits (65), Expect = 8.0
 Identities = 51/240 (21%), Positives = 89/240 (37%), Gaps = 49/240 (20%)

Query: 322 SNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKG--PPRNLLCEQPTVP-RENGKPEA 378
           + P+  +WM+D  KG           +E+ G   +    P   + E P++   +  + + 
Sbjct: 174 TGPDDFEWMSDERKG-----------NEKDGGHTQHFESPTMKIQEHPSLSDTKQQRNQD 222

Query: 379 AGPEPSSSGEETPDAALTCL---KERREQLPPQEDSKVTKQDKNLIKPLYDRYRIIKQIL 435
           AG +  S   E P + LT L   K   E +P     +    D +         R+I+Q+L
Sbjct: 223 AGDQEESFVSEVPQSDLTALCDEKNWEEPIPAFSSWQRENSDSDEAHLSPQAGRLIRQLL 282

Query: 436 ---STPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSNETEPVRALLPDE 492
              S P L P       S +        PS   P SH       ++            DE
Sbjct: 283 DEDSDPMLSPRFYAYGQSRQYLDDTEVPPS--PPNSH-------SFMRRRSSSLGSYDDE 333

Query: 493 KKEVKPPALSMSNLHEATMPVLLDHLRETRADKKRLRKALREFEEQFFKQTGRSPQKEDR 552
           ++++ P  L+                R  ++ KK++RK    FE++F ++    P   D+
Sbjct: 334 QEDLTPAQLT----------------RRIQSLKKKIRK----FEDRFEEEKKYRPSHSDK 373


>gi|156142190 hypothetical protein LOC51306 isoform 2 [Homo sapiens]
          Length = 887

 Score =  243 bits (621), Expect = 3e-64
 Identities = 165/429 (38%), Positives = 241/429 (56%), Gaps = 47/429 (10%)

Query: 190 LADGTDSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGD-NPLLSPRCSIFSQSQ 248
           ++DG    +P P  K  Q +++S    L S    R+ +H  + D  P+LS R   F QSQ
Sbjct: 473 VSDGDKWEEPFPAFKSWQEDSESGEAQL-SPQAGRMNHHPLEEDCPPVLSHRSLDFGQSQ 531

Query: 249 RFNLDPESAPSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKIRKFEEKFE 308
           RF  DPE   S      F   R SS  S  + +E +T  QL K +Q   +KIR+FEE+FE
Sbjct: 532 RFLHDPEKLDSSSKALSFTRIRRSSFSSKDEKREDRTPYQLVKKLQ---KKIRQFEEQFE 588

Query: 309 QEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPRNLLCEQPT 368
           +E+  +PS+ D  +NP+VLKWM +L K RKQ+K+ K K S+ +   P+  PR+      T
Sbjct: 589 RERNSKPSYSDIAANPKVLKWMTELTKLRKQIKDAKHKNSDGE-FVPQTRPRS-----NT 642

Query: 369 VPRENG------------KPEAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSKVTKQ 416
           +P+  G            +P+    E   S E T +  L  LKE+R +    ED KVTK+
Sbjct: 643 LPKSFGSSLDHEDEENEDEPKVIQKEKKPSKEATLELILKRLKEKRIERCLPEDIKVTKE 702

Query: 417 DKNLIKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQ-QPSLADPASHL----- 470
           +++++KPLYDRYR++KQ+L+  S+ P +     S   + +G   QP +    +H      
Sbjct: 703 ERHIVKPLYDRYRLVKQMLTRASITPVL----GSPSTKRRGQMLQPIIEGETAHFFEEIK 758

Query: 471 -PVGDHLTYSNE-------TEPVRALLPDEKKEVKPPA------LSMSNLHEATMPVLLD 516
               D +  S+E          V++ L + + +V+         L +S+   A+MP LL+
Sbjct: 759 EEEEDGVNLSSELGDMLKTAVQVQSSLENSESDVEENQEKLALDLRLSSSRAASMPELLE 818

Query: 517 HLRETRADKKRLRKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLI 576
            L + RA+KK+LRK LREFEE F++Q GR+ QKEDR+P+ +EY EYK IKAKLRLLEVLI
Sbjct: 819 QLWKARAEKKKLRKTLREFEEAFYQQNGRNAQKEDRVPVLEEYREYKKIKAKLRLLEVLI 878

Query: 577 SKQDVAKTI 585
           SKQD +K+I
Sbjct: 879 SKQDSSKSI 887


>gi|156142192 hypothetical protein LOC51306 isoform 3 [Homo sapiens]
          Length = 791

 Score =  242 bits (618), Expect = 6e-64
 Identities = 164/424 (38%), Positives = 238/424 (56%), Gaps = 47/424 (11%)

Query: 195 DSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGD-NPLLSPRCSIFSQSQRFNLD 253
           D  +P P  K  Q +++S    L S    R+ +H  + D  P+LS R   F QSQRF  D
Sbjct: 382 DGEEPFPAFKSWQEDSESGEAQL-SPQAGRMNHHPLEEDCPPVLSHRSLDFGQSQRFLHD 440

Query: 254 PESAPSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKY 313
           PE   S      F   R SS  S  + +E +T  QL K +Q   +KIR+FEE+FE+E+  
Sbjct: 441 PEKLDSSSKALSFTRIRRSSFSSKDEKREDRTPYQLVKKLQ---KKIRQFEEQFERERNS 497

Query: 314 RPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPRNLLCEQPTVPREN 373
           +PS+ D  +NP+VLKWM +L K RKQ+K+ K K S+ +   P+  PR+      T+P+  
Sbjct: 498 KPSYSDIAANPKVLKWMTELTKLRKQIKDAKHKNSDGE-FVPQTRPRS-----NTLPKSF 551

Query: 374 G------------KPEAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKNLI 421
           G            +P+    E   S E T +  L  LKE+R +    ED KVTK++++++
Sbjct: 552 GSSLDHEDEENEDEPKVIQKEKKPSKEATLELILKRLKEKRIERCLPEDIKVTKEERHIV 611

Query: 422 KPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQ-QPSLADPASHL------PVGD 474
           KPLYDRYR++KQ+L+  S+ P +     S   + +G   QP +    +H          D
Sbjct: 612 KPLYDRYRLVKQMLTRASITPVL----GSPSTKRRGQMLQPIIEGETAHFFEEIKEEEED 667

Query: 475 HLTYSNE-------TEPVRALLPDEKKEVKPPA------LSMSNLHEATMPVLLDHLRET 521
            +  S+E          V++ L + + +V+         L +S+   A+MP LL+ L + 
Sbjct: 668 GVNLSSELGDMLKTAVQVQSSLENSESDVEENQEKLALDLRLSSSRAASMPELLEQLWKA 727

Query: 522 RADKKRLRKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLISKQDV 581
           RA+KK+LRK LREFEE F++Q GR+ QKEDR+P+ +EY EYK IKAKLRLLEVLISKQD 
Sbjct: 728 RAEKKKLRKTLREFEEAFYQQNGRNAQKEDRVPVLEEYREYKKIKAKLRLLEVLISKQDS 787

Query: 582 AKTI 585
           +K+I
Sbjct: 788 SKSI 791


>gi|156142188 hypothetical protein LOC51306 isoform 1 [Homo sapiens]
          Length = 915

 Score =  228 bits (582), Expect = 9e-60
 Identities = 165/457 (36%), Positives = 241/457 (52%), Gaps = 75/457 (16%)

Query: 190 LADGTDSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGD-NPLLSPRCSIFSQSQ 248
           ++DG    +P P  K  Q +++S    L S    R+ +H  + D  P+LS R   F QSQ
Sbjct: 473 VSDGDKWEEPFPAFKSWQEDSESGEAQL-SPQAGRMNHHPLEEDCPPVLSHRSLDFGQSQ 531

Query: 249 RFNLDPESAPSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKIRKFEEKFE 308
           RF  DPE   S      F   R SS  S  + +E +T  QL K +Q   +KIR+FEE+FE
Sbjct: 532 RFLHDPEKLDSSSKALSFTRIRRSSFSSKDEKREDRTPYQLVKKLQ---KKIRQFEEQFE 588

Query: 309 QEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPRNLLCEQPT 368
           +E+  +PS+ D  +NP+VLKWM +L K RKQ+K+ K K S+ +   P+  PR+      T
Sbjct: 589 RERNSKPSYSDIAANPKVLKWMTELTKLRKQIKDAKHKNSDGE-FVPQTRPRS-----NT 642

Query: 369 VPRENG------------KPEAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSK---- 412
           +P+  G            +P+    E   S E T +  L  LKE+R +    ED K    
Sbjct: 643 LPKSFGSSLDHEDEENEDEPKVIQKEKKPSKEATLELILKRLKEKRIERCLPEDIKKMTK 702

Query: 413 ------------------------VTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEEE 448
                                   VTK++++++KPLYDRYR++KQ+L+  S+ P +    
Sbjct: 703 DHLVEEKASLQKSLLYYESQHGRPVTKEERHIVKPLYDRYRLVKQMLTRASITPVL---- 758

Query: 449 DSDEDRPQGSQ-QPSLADPASHL------PVGDHLTYSNE-------TEPVRALLPDEKK 494
            S   + +G   QP +    +H          D +  S+E          V++ L + + 
Sbjct: 759 GSPSTKRRGQMLQPIIEGETAHFFEEIKEEEEDGVNLSSELGDMLKTAVQVQSSLENSES 818

Query: 495 EVKPPA------LSMSNLHEATMPVLLDHLRETRADKKRLRKALREFEEQFFKQTGRSPQ 548
           +V+         L +S+   A+MP LL+ L + RA+KK+LRK LREFEE F++Q GR+ Q
Sbjct: 819 DVEENQEKLALDLRLSSSRAASMPELLEQLWKARAEKKKLRKTLREFEEAFYQQNGRNAQ 878

Query: 549 KEDRIPMADEYYEYKHIKAKLRLLEVLISKQDVAKTI 585
           KEDR+P+ +EY EYK IKAKLRLLEVLISKQD +K+I
Sbjct: 879 KEDRVPVLEEYREYKKIKAKLRLLEVLISKQDSSKSI 915


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 82/374 (21%), Positives = 147/374 (39%), Gaps = 34/374 (9%)

Query: 197  ADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPRCSIFSQSQRFNLDPES 256
            A P PV  +  ++  + P  +  V            +  + +    +  +  +  L  E 
Sbjct: 1134 ASPMPVPTESSSQKTAVPPQVKLVKKQ---------EQEVKTEAEKVILEKVKETLSMEK 1184

Query: 257  APSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKIRKFEEK-FEQEKKYRP 315
             P   +T Q        +      +E + + +  K I   + KIR  E+K   +EKK  P
Sbjct: 1185 IPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPE-EEKIRSEEKKPLLEEKKPTP 1243

Query: 316  SHGD-----KTSNPEVLKWMNDLAKGRKQLKELKLK-----LSEEQGSAPKGPPRNLLCE 365
                     KTS PE  K  +DL K + Q+ E KL+      + ++G  P+     L   
Sbjct: 1244 EDKKLLPEAKTSAPEEQK--HDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSG 1301

Query: 366  QP-TVPRENGKP-EAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKN---L 420
             P ++P+E+ K  +    +P       PD      KE+ E+   + D+  ++Q K+   L
Sbjct: 1302 TPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPG-KEKTEKEDDKSDTSSSQQPKSPQGL 1360

Query: 421  IKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSN 480
                Y    I   +   PSLIPT +++      +   SQ+ S + P+    +    T  +
Sbjct: 1361 SDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKL--ESTVLS 1418

Query: 481  ETEPVRALLPDEKKEVK--PPALSMSNLHEATMPVLLDHLRETRADKKRLRKALREFEEQ 538
              E   + L DEK E K  P  +S     +      L    E    ++ ++++  E ++ 
Sbjct: 1419 ILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDT 1478

Query: 539  FFKQTGRS-PQKED 551
            F K + +  P  +D
Sbjct: 1479 FKKDSQQDIPSSKD 1492



 Score = 30.0 bits (66), Expect = 6.2
 Identities = 42/228 (18%), Positives = 80/228 (35%), Gaps = 22/228 (9%)

Query: 255 ESAPSPPST--QQFMMPRSSSRCSCGDGKEPQTITQLTKH------------IQSLKRKI 300
           +S+P P  T  ++   P+     +    K P  + Q T H              SL +  
Sbjct: 674 KSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPA 733

Query: 301 RKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPR 360
              E     E+   P   DK   P+++K   DL        +  +  S+ Q  A +    
Sbjct: 734 PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP 793

Query: 361 NLLCEQ--------PTVPRENGKPEAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSK 412
            L  +         PT  + +     A P P+S  +       +   + ++Q+ P +  +
Sbjct: 794 PLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKE 853

Query: 413 VTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQ 460
             K+ +  + P  D   + K   + P   PT  +   + +  P+  +Q
Sbjct: 854 EPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQ 901


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 82/374 (21%), Positives = 147/374 (39%), Gaps = 34/374 (9%)

Query: 197  ADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPRCSIFSQSQRFNLDPES 256
            A P PV  +  ++  + P  +  V            +  + +    +  +  +  L  E 
Sbjct: 1134 ASPMPVPTESSSQKTAVPPQVKLVKKQ---------EQEVKTEAEKVILEKVKETLSMEK 1184

Query: 257  APSPPSTQQFMMPRSSSRCSCGDGKEPQTITQLTKHIQSLKRKIRKFEEK-FEQEKKYRP 315
             P   +T Q        +      +E + + +  K I   + KIR  E+K   +EKK  P
Sbjct: 1185 IPPMVTTDQKQEESKLEKDKASALQEKKPLPEEKKLIPE-EEKIRSEEKKPLLEEKKPTP 1243

Query: 316  SHGD-----KTSNPEVLKWMNDLAKGRKQLKELKLK-----LSEEQGSAPKGPPRNLLCE 365
                     KTS PE  K  +DL K + Q+ E KL+      + ++G  P+     L   
Sbjct: 1244 EDKKLLPEAKTSAPEEQK--HDLLKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSG 1301

Query: 366  QP-TVPRENGKP-EAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKN---L 420
             P ++P+E+ K  +    +P       PD      KE+ E+   + D+  ++Q K+   L
Sbjct: 1302 TPQSLPKEDDKTTKTIKEQPQPPCTAKPDQVEPG-KEKTEKEDDKSDTSSSQQPKSPQGL 1360

Query: 421  IKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSN 480
                Y    I   +   PSLIPT +++      +   SQ+ S + P+    +    T  +
Sbjct: 1361 SDTGYSSDGISSSLGEIPSLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKL--ESTVLS 1418

Query: 481  ETEPVRALLPDEKKEVK--PPALSMSNLHEATMPVLLDHLRETRADKKRLRKALREFEEQ 538
              E   + L DEK E K  P  +S     +      L    E    ++ ++++  E ++ 
Sbjct: 1419 ILEAQASTLADEKSEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDT 1478

Query: 539  FFKQTGRS-PQKED 551
            F K + +  P  +D
Sbjct: 1479 FKKDSQQDIPSSKD 1492



 Score = 30.0 bits (66), Expect = 6.2
 Identities = 42/228 (18%), Positives = 80/228 (35%), Gaps = 22/228 (9%)

Query: 255 ESAPSPPST--QQFMMPRSSSRCSCGDGKEPQTITQLTKH------------IQSLKRKI 300
           +S+P P  T  ++   P+     +    K P  + Q T H              SL +  
Sbjct: 674 KSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAKQPPEADSLSKPA 733

Query: 301 RKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPR 360
              E     E+   P   DK   P+++K   DL        +  +  S+ Q  A +    
Sbjct: 734 PPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTP 793

Query: 361 NLLCEQ--------PTVPRENGKPEAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSK 412
            L  +         PT  + +     A P P+S  +       +   + ++Q+ P +  +
Sbjct: 794 PLKTDSAKPSQSFPPTGEKVSPFDSKAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKE 853

Query: 413 VTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQ 460
             K+ +  + P  D   + K   + P   PT  +   + +  P+  +Q
Sbjct: 854 EPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTPQQSPKPQEQ 901


>gi|54112380 F-box and leucine-rich repeat protein 10 isoform b
           [Homo sapiens]
          Length = 1265

 Score = 41.6 bits (96), Expect = 0.002
 Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 27/169 (15%)

Query: 298 RKIRKFE--EKFEQEKKYRPSHGDKTSNPEVLKWMND---LAKGRKQLKELKLKLSEEQG 352
           RK RK+E  ++    K+ +P   DK    +   W N    +A   K L+  K    E + 
Sbjct: 770 RKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFK---QEPED 826

Query: 353 SAPKGPPRNLLCEQPTVPRENGKPEAAGPE--PSSSGEETPDAALTCLKERREQLPPQED 410
             P+ PP+          RE+    ++ P   PS+ G E P+        R+ +LP +E 
Sbjct: 827 ELPEAPPKT---------RESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKEL 877

Query: 411 SKVTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEEEDSDED--RPQG 457
           S      + L K L    +  +  L+  +  P   E E   E+  RP G
Sbjct: 878 S------RELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKRPPG 920


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 41.2 bits (95), Expect = 0.003
 Identities = 104/491 (21%), Positives = 167/491 (34%), Gaps = 105/491 (21%)

Query: 123 RAGTPAHESPQNNAFK-CQETV--RLQPRIDQRTAISPKDAFETRQDLNEEEAAQVHGVK 179
           R G P  E  + +  K C+  V  +  P   +    S K+A E   D  EE + +    K
Sbjct: 307 RPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAK 366

Query: 180 DPAPASTQSVLADGTDSADPSPVHKDGQNEAD------SAPEDLHSVG---TSRLLYHIT 230
           +P   +  S L +G+  A       +   E        S P+  H +     SR+  H+ 
Sbjct: 367 EPKKKA--SALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLL 424

Query: 231 DGD--NPLLSPRCSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDGKEPQTITQ 288
           D D  +P+L   C    Q     L  E      S+Q  +  + S       G E +    
Sbjct: 425 DVDVLSPVLGGACRQAQQP----LGIEDKDDSQSSQDELQSKQSK------GLEERLSPP 474

Query: 289 LT--KHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLK 346
           L   +  QS  R +   EE         P  G +   PE   W      G      L L+
Sbjct: 475 LPHEERAQSPPRSLATEEE---------PPQGPE-GQPE---WKEAEELGEDSAASLSLQ 521

Query: 347 LSEEQGSAPKGP-------------------------PRNLLCEQPTVPRENGKPEAAGP 381
           LS ++  AP  P                         P   +   PT P     PE    
Sbjct: 522 LSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVS---PEVRST 578

Query: 382 EPSSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKNLIKPLYDR------------YR 429
           EP +  E+  +AAL  ++E   Q+  Q+   + +  +  ++ L ++            ++
Sbjct: 579 EPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQ 638

Query: 430 IIKQILST--PSLIPTIQEEE----------------------DSDEDRPQGSQQPSLAD 465
             +Q LS+    L   I+EEE                       +DED+ +  Q+ SL  
Sbjct: 639 QKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQK 698

Query: 466 PASHLPVGDHLTYSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETRADK 525
               L        ++  +  R +L   K+E++    S      A     L  LRE    +
Sbjct: 699 LREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGE 758

Query: 526 KRLRKALREFE 536
           ++   A  E E
Sbjct: 759 RKEAVATLEKE 769


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 39.7 bits (91), Expect = 0.008
 Identities = 62/294 (21%), Positives = 99/294 (33%), Gaps = 38/294 (12%)

Query: 242 SIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRC-------------------SCGDGKE 282
           S F   +R     + AP PP     +   SSSR                    S    +E
Sbjct: 149 SSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRE 208

Query: 283 PQTITQLTKH---IQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQ 339
            +  ++  KH    +S KRK R    K +++ K +     +++ P         +     
Sbjct: 209 RKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADS 268

Query: 340 LKELKLKLSEEQGSAPKGPPRNLLCEQPT-VPRENGKPEAAGPEPSSSGEETPDAALTCL 398
                   S  + +A K     L    P+      G+ +A   EP ++  + P +  T  
Sbjct: 269 ASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETAT 328

Query: 399 KERREQLPPQEDSKVTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGS 458
           K+      P ED    K++K+  +P     R        P+  P + E       R  GS
Sbjct: 329 KQPSS---PYEDKDKDKKEKSATRPSPSPER-SSTGPEPPAPTPLLAE-------RHGGS 377

Query: 459 QQPSLADPASHLPVGDHLTYSNETEPVRALLPDEKKEVKPPALSMSNLHEATMP 512
            QP    P S  PV       +E  P R   P +  E  P + S  +   +  P
Sbjct: 378 PQPLATTPLSQEPVNP----PSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQP 427



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 56/282 (19%), Positives = 95/282 (33%), Gaps = 47/282 (16%)

Query: 116  SQSECQVRAGTPAHESPQNNAFKCQETVRLQPRIDQRTAISPKDAFETRQDLNEEEAAQV 175
            S  E   +  TP  E   + +   Q+TV   P + QR+        + +   + +E ++ 
Sbjct: 1501 SSPELNNKCLTPQRERSGSESSVDQKTVARTP-LGQRSRSGSSQELDVKPSASPQERSES 1559

Query: 176  HGVKDPAPASTQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGDNP 235
                D + A T++ L   + S     V     +++  +P    S  +  +       D P
Sbjct: 1560 DSSPD-SKAKTRTPLRQRSRSGSSPEV----DSKSRLSPRRSRSGSSPEVK------DKP 1608

Query: 236  LLSPRCSIFSQSQRFNLDPESAPSPPSTQQFMMPRSSSRCSCGDGKEPQ-----TITQLT 290
              +PR    S         +S+P P +     +PR S   S   G+ P      +     
Sbjct: 1609 RAAPRAQSGS---------DSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSP 1659

Query: 291  KHIQSLKRKIRKFEEKFEQEKKYR--PSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLS 348
            +H    +   R      E + K R  P      S+PE+ +               K +LS
Sbjct: 1660 EHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTR---------------KARLS 1704

Query: 349  EEQGSAPKGPPRNLLCEQPTVPRENGKPEAAGPEPSSSGEET 390
                SA   P         T PR    P  + PEP+     +
Sbjct: 1705 RRSRSASSSPETR----SRTPPRHRRSPSVSSPEPAEKSRSS 1742



 Score = 30.0 bits (66), Expect = 6.2
 Identities = 57/285 (20%), Positives = 88/285 (30%), Gaps = 17/285 (5%)

Query: 7    FSLQDNSFSSTTVTECDEDPVSLHEDQTDCSSLRDENNKENYPDAGALVEEHAPPSWEPQ 66
            FS Q     + T        +S     T  SS  D N   + P  G    +   P     
Sbjct: 2455 FSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTG 2514

Query: 67   QQNVEATVLVDSVLRPSMGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSECQVRAGT 126
             Q   A     + L+P+    K R+  S   + S  S   S  +    SS S      G+
Sbjct: 2515 AQQPSAL----AALQPA----KERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGS 2566

Query: 127  PAHESPQNNAFKCQETVRLQPRIDQRTAISPKDAFETRQDLNEEEAAQVHGVKDPAPAST 186
                 P+  A K   +    P+   R    P+     R+  +   ++        + +S+
Sbjct: 2567 SLPVQPEV-ALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSS 2625

Query: 187  QSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPRCSIFSQ 246
             S  +  + S+  S       +    A     ++           G+    SPR  I S 
Sbjct: 2626 SSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSL 2685

Query: 247  SQRFNLD--------PESAPSPPSTQQFMMPRSSSRCSCGDGKEP 283
                +L         P   PSP   Q     R S R   GD + P
Sbjct: 2686 RDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSP 2730


>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
           homolog 2 [Homo sapiens]
          Length = 1210

 Score = 38.9 bits (89), Expect = 0.013
 Identities = 76/369 (20%), Positives = 135/369 (36%), Gaps = 37/369 (10%)

Query: 165 QDLNEEEAAQVHGVKD---------PAPASTQSVLADGTDSADPSPVHKDGQNEADSAPE 215
           Q + +  + +VH V++         P P +     +    S  P P  KD Q+ +     
Sbjct: 343 QSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPT-KDSQHVSSVTQN 401

Query: 216 DLHSVGTSRLLYHITDGDNPLLSPRCSIF----SQSQRFNLDPESAPSPPSTQQFMMPRS 271
                 +S+   +   G + +L     +     S S++    P S+ +PPS  Q +    
Sbjct: 402 QKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPV 461

Query: 272 SSRCSCGDGKEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMN 331
           +S  S     E ++ +       S         E+ E  +   P     T+N    KW  
Sbjct: 462 ASAHS--SSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTN----KWQL 515

Query: 332 DLAKGRKQLKELKLKLSEEQGSAPKGPPR----NLLCEQPTVPRENGKPEAAGPEPSSSG 387
           D       L ++    +  +G     PPR    +         +E+ + +   P+ SS  
Sbjct: 516 D-----NWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKA 570

Query: 388 EETPDAA-----LTCLKERREQLPPQEDSKVTKQDKNLIK-PLYDRYRIIKQILSTPSLI 441
              P  A      +C K   +Q PPQ  +  TKQ K  +K       R   Q    P L+
Sbjct: 571 PRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLL 630

Query: 442 PTIQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSNETEPVRALLPDEKKEVKPPAL 501
           P    ++ S +D+P+   +      AS+ P    +  S+E +  ++ LP   K +  P  
Sbjct: 631 PYGSRDQTS-KDKPKVKTKGRPRAAASNEP-KPAVPPSSEKKKHKSSLPAPSKALSGPEP 688

Query: 502 SMSNLHEAT 510
           +  N+ + T
Sbjct: 689 AKDNVEDRT 697


>gi|238624188 diffuse panbronchiolitis critical region 1 protein
           [Homo sapiens]
          Length = 1393

 Score = 38.5 bits (88), Expect = 0.017
 Identities = 91/466 (19%), Positives = 159/466 (34%), Gaps = 58/466 (12%)

Query: 104 HGESQETEHVVSSQSE-CQVRAGTP-AHESPQNNAFKCQETVRLQPRIDQRTAISPKDAF 161
           HGE    E+   S +E  +    TP A++   +++ +  E     P  ++ T  SP +  
Sbjct: 383 HGERTANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPT 442

Query: 162 ETRQDL--------------NEEEAAQVHGVKDPA-PASTQSVLADGTDSADPSPVHKDG 206
           E R+                N E  A       P  P   +   A+   +  P+   ++G
Sbjct: 443 ENRERTANENTTPSPAGPTENRETTANEKTTLSPVEPTENRETTANEKTTPSPAEPTENG 502

Query: 207 QNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPRCSIFSQSQRFNLDPESAPSPPSTQQF 266
           Q    +  +   S          T   N   +P  +  ++++    + ++ PSP    + 
Sbjct: 503 QRTPFANEKTTSSSAEPTEHGERTPLANENTTPSPAEPTENRERTANEKTTPSPAEPTE- 561

Query: 267 MMPRSSSRCSCGDGKEPQTITQLTKHIQSL----KRKIRKFEEKFEQEKKY-------RP 315
               +  R    + K   ++ + T++ Q      ++      E  E E++         P
Sbjct: 562 ----NGDRTPLANEKTTPSLAEPTENGQRTPFANEKTTSSSAEPTEHEERTPLANENTTP 617

Query: 316 SHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPRNL-------LCEQPT 368
           S  + T N E     N         +  ++  +E+    P  P  N            P 
Sbjct: 618 SPAEPTENRERTANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTANEKTTSSPA 677

Query: 369 VPRENG--------KPEAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKNL 420
            P ENG        K  ++  EP+  GE TP A         E    +E +   K     
Sbjct: 678 EPTENGQRTPFANEKTTSSSAEPTEHGERTPLANENTTLSPAEPTENRERTANEKTTPFP 737

Query: 421 IKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLPVGDHLTYSN 480
            +P  +R R   +  +TPS  P    E             PSLA+P  +   G    ++N
Sbjct: 738 AEPTENRERTANE-NTTPS--PAQPTENGDRTPLANEKTTPSLAEPTEN---GKRTPFAN 791

Query: 481 ETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETRADKK 526
           E     +  P E  E  P    ++N +  + P      RE  A++K
Sbjct: 792 EKTTSSSAEPTEHAERTP----LANENTTSSPAEPTENRERTANEK 833



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 93/503 (18%), Positives = 175/503 (34%), Gaps = 73/503 (14%)

Query: 32   DQTDCSSLRDENNKENYPDAGALVEEHAPPSWEPQQQNVEATVLVDSVLRPSMGNFKSRK 91
            ++T  SS     ++E  P    L  E+  PS     +N E T   ++   P+ G  ++R+
Sbjct: 592  EKTTSSSAEPTEHEERTP----LANENTTPSPAEPTENRERTANENTTPSPA-GPTENRE 646

Query: 92   -----PKSIFKAESGRSHGESQETEHVVSSQSECQVRAGTP-AHESPQNNAFKCQETVRL 145
                   ++F AE   +   +   +   S     +    TP A+E   +++ +  E    
Sbjct: 647  MTANEKTTLFPAEPTENRERTANEKTTSSPAEPTENGQRTPFANEKTTSSSAEPTEHGER 706

Query: 146  QPRIDQRTAISPKDAFETRQDL--------------NEEEAAQVHGVKDPAPAS------ 185
             P  ++ T +SP +  E R+                N E  A  +    PA  +      
Sbjct: 707  TPLANENTTLSPAEPTENRERTANEKTTPFPAEPTENRERTANENTTPSPAQPTENGDRT 766

Query: 186  ------TQSVLADGTDSADPSPVHKDGQNEADSAPEDLHSVGTSRLLYHITDGD-NPLLS 238
                  T   LA+ T++   +P   +    + + P + H+  T     + T     P  +
Sbjct: 767  PLANEKTTPSLAEPTENGKRTPFANEKTTSSSAEPTE-HAERTPLANENTTSSPAEPTEN 825

Query: 239  PRCSIFSQSQRFNLDP----ESA--------PSPPSTQQFMMPRSSSRCSCGDGKEPQTI 286
               +   ++ +F  +P    ES         P+ P+  +      ++  S  +  E + +
Sbjct: 826  RERTANEKTTQFPAEPTENRESTANEKTTPFPAEPTENREWTANENTTLSPAEPTEHEEM 885

Query: 287  TQLTKHIQSLK--RKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAK-GRKQLKEL 343
            T L     +L         E      +K  PS  + T + E     N++    R +  E 
Sbjct: 886  TPLANEKTTLSPAEPTENGERTPFTNEKTTPSSAEPTEHGERTPLANEITTPSRAEPTEH 945

Query: 344  KLKLSEEQGSAPKGPPRNLLCEQPTVPRENGKPEAAGPEPSSSGEETPDAALTCLKERRE 403
              +++ E+ +             P  P E+G+         SS E T +   T L     
Sbjct: 946  GERIANEKATP-----------SPAKPTEHGETTVNEDTTPSSAEPTENGERTPLANENT 994

Query: 404  QLPPQEDS---KVTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQ 460
               P E +   + T  +K    P        +   +    IP+  +  + +E  P  ++ 
Sbjct: 995  TTSPTESTEHGERTANEKTTPSPAEPTEHGERTPSANEKTIPSPAKPTEHEEMTPSANEN 1054

Query: 461  --PSLADPASHLPVGDHLTYSNE 481
              PS   P  H   G+  T +NE
Sbjct: 1055 TTPSPVKPTEH---GEKTTLANE 1074


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 38.5 bits (88), Expect = 0.017
 Identities = 65/281 (23%), Positives = 111/281 (39%), Gaps = 39/281 (13%)

Query: 291 KHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLK---ELKLKL 347
           K ++ L+ K RK EE+ EQEK+ R    +K     + K    L K +++ +   E  LKL
Sbjct: 367 KRLEELEAK-RKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKL 425

Query: 348 SEEQG-------SAPKGPPRNLLCEQPTVPRENGKPEAAGPEPSSSGEETPDAALTCLKE 400
            + QG       S PK  P     ++  +P++    E +      +  E  +  +   +E
Sbjct: 426 LQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEE 485

Query: 401 RREQLPPQE----------DSKVTKQDKNLIKPLYDRYRI-IKQILSTPSLIPTIQEEED 449
               + P+E          D +    D+   K   ++  I +K+        P  +EEE+
Sbjct: 486 TPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKE-------NPEEEEEEE 538

Query: 450 SDEDRPQGSQQPSLADPASHLPVGDHLTYSNETEPVRALLPDEKKEVKPPALSMSNLHEA 509
            +E+  + S++    +  S    GD      E E V       K   K P+  MS+  E 
Sbjct: 539 EEEEEDEESEEEEEEEGESEGSEGD-----EEDEKVSDEKDSGKTLDKKPSKEMSSDSEY 593

Query: 510 TMPVLLDHLRETRA---DKKRLRKALREFEEQFFKQTGRSP 547
                 D  +E RA    K+R+ K   E  +    +  R+P
Sbjct: 594 DSDD--DRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAP 632



 Score = 29.6 bits (65), Expect = 8.0
 Identities = 28/128 (21%), Positives = 52/128 (40%), Gaps = 9/128 (7%)

Query: 297 KRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPK 356
           K K+RK +EK E E   +     K S     K+  +  K +  +    +  SEE+   P 
Sbjct: 247 KAKLRKLKEKEELETGKKDQSKQKESQR---KFEEETVKSKVTVDTGVIPASEEKAETPT 303

Query: 357 GPPRNLLCEQPTVPRENGKPEAAGPE------PSSSGEETPDAALTCLKERREQLPPQED 410
               +   ++    ++  K E    E      PS +  +    AL  LKE  E+   +E+
Sbjct: 304 AAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEE 363

Query: 411 SKVTKQDK 418
            ++ + ++
Sbjct: 364 ERIKRLEE 371


>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
          Length = 2481

 Score = 38.1 bits (87), Expect = 0.023
 Identities = 58/234 (24%), Positives = 92/234 (39%), Gaps = 38/234 (16%)

Query: 179  KDPAPASTQSVLADGTDSADPSPVH-KDGQNEADSAPEDLHSVGTSRLLYHITDGDNPLL 237
            K PA +S+   ++ G  S   S +  KD  ++    P       TS+L       D PL 
Sbjct: 2234 KPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQL-------DQPLF 2286

Query: 238  ------SPRCSIFSQSQRFNLDPES-----APSPPSTQQFMMPRSSSRCSCGDGKEPQTI 286
                  SP  +  S+S R N+ P S     A S PS         S+R S  D  +   +
Sbjct: 2287 KLKYPSSPYSAHISKSPR-NMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAPDIDKL 2345

Query: 287  TQ--LTKHIQSLKRKIRKFEEKFEQE-----KKYRPSHGDKTSNPEVLKWMN------DL 333
                + + +Q++   ++ F +   Q      K +R + G  TS  +VL  +N        
Sbjct: 2346 KMAAIDEKVQAV-HNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPRHNKK 2404

Query: 334  AKGRKQLKELKLKLSEEQGSAPKGPP----RNLLCEQPTVPRENGKPEAAGPEP 383
             +G  +L+  +L L +  G+ PK PP    R       ++P   G P  A   P
Sbjct: 2405 EEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARP 2458


>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
           sapiens]
          Length = 756

 Score = 38.1 bits (87), Expect = 0.023
 Identities = 52/236 (22%), Positives = 84/236 (35%), Gaps = 45/236 (19%)

Query: 365 EQPTVPRENGKPEAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKNLIKPL 424
           E P+   E   PEA  P+P SS  E     + C   R +  P Q + K         +P 
Sbjct: 522 EDPSSQEEAHTPEAPPPQPPSS--ERCLGEMKCTLVRGDSSPRQAELKSGPAS----RPA 575

Query: 425 YDRYRIIKQILSTPSLIP-----TIQEEEDSDEDRP--------QGSQQPSLADPASHLP 471
            ++    ++  + P   P     T +EE   +E RP        +G            LP
Sbjct: 576 LEKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELP 635

Query: 472 VGDHLTYSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDH-----------LRE 520
             + +    E  P+      + + +KPP  S   L    +P L+             +  
Sbjct: 636 PKEEVAPKEEVPPIERAFAQKTRPIKPPPDSQETL---ALPSLVPQNYTENKNEGVDVTS 692

Query: 521 TRADKKRLRKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLI 576
            R + + LR+AL   E Q  ++            + D + E K  K + R LEV +
Sbjct: 693 LRGEVESLRRALELMEVQLERK------------LTDIWEELKSEKEQRRRLEVQV 736


>gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [Homo
           sapiens]
          Length = 645

 Score = 38.1 bits (87), Expect = 0.023
 Identities = 52/236 (22%), Positives = 84/236 (35%), Gaps = 45/236 (19%)

Query: 365 EQPTVPRENGKPEAAGPEPSSSGEETPDAALTCLKERREQLPPQEDSKVTKQDKNLIKPL 424
           E P+   E   PEA  P+P SS  E     + C   R +  P Q + K         +P 
Sbjct: 411 EDPSSQEEAHTPEAPPPQPPSS--ERCLGEMKCTLVRGDSSPRQAELKSGPAS----RPA 464

Query: 425 YDRYRIIKQILSTPSLIP-----TIQEEEDSDEDRP--------QGSQQPSLADPASHLP 471
            ++    ++  + P   P     T +EE   +E RP        +G            LP
Sbjct: 465 LEKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPLREEVLPKEGVASKEEVTLKEELP 524

Query: 472 VGDHLTYSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDH-----------LRE 520
             + +    E  P+      + + +KPP  S   L    +P L+             +  
Sbjct: 525 PKEEVAPKEEVPPIERAFAQKTRPIKPPPDSQETL---ALPSLVPQNYTENKNEGVDVTS 581

Query: 521 TRADKKRLRKALREFEEQFFKQTGRSPQKEDRIPMADEYYEYKHIKAKLRLLEVLI 576
            R + + LR+AL   E Q  ++            + D + E K  K + R LEV +
Sbjct: 582 LRGEVESLRRALELMEVQLERK------------LTDIWEELKSEKEQRRRLEVQV 625


>gi|118442841 hypothetical protein LOC123591 [Homo sapiens]
          Length = 531

 Score = 38.1 bits (87), Expect = 0.023
 Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 11/110 (10%)

Query: 8   SLQDNSFSSTTVTECDEDPVSLHEDQTDCSSLRDENNKENYPDAGALVEEHAPPSWEPQQ 67
           S    S S ++VT    D         DCS+ R+E + E  P         +PP    QQ
Sbjct: 383 SATSESASRSSVTRAQSDSSQTLGSSMDCSTAREEPSSEPGP---------SPPPLPSQQ 433

Query: 68  QNVEATV--LVDSVLRPSMGNFKSRKPKSIFKAESGRSHGESQETEHVVS 115
           Q  EATV  L+ S+      + K+  P  + +     S   S E EH VS
Sbjct: 434 QVEEATVQDLLSSLSEDPCPSQKALDPAPLARPSPAGSAQTSPELEHRVS 483


>gi|239740773 PREDICTED: similar to diffuse panbronchiolitis
           critical region 1 [Homo sapiens]
          Length = 1400

 Score = 37.7 bits (86), Expect = 0.030
 Identities = 94/471 (19%), Positives = 163/471 (34%), Gaps = 68/471 (14%)

Query: 104 HGESQETEHVVSSQSE-CQVRAGTP-AHESPQNNAFKCQETVRLQPRIDQRTAISPKDAF 161
           HGE    E+   S +E  +    TP A++   +++ +  E     P  ++ T  SP +  
Sbjct: 445 HGERTANENTTPSPAEPTEHGERTPFANDKTTSSSAESTEHGERTPLANENTTPSPAEPT 504

Query: 162 ETRQDL--------------NEEEAAQVHGVKDPA-PASTQSVLADGTDSADPSPVHKDG 206
           E R+                N E  A       P  P   +   A+   +  P+   ++G
Sbjct: 505 ENRERTANENTTPSPAGPTENRETTANEKTTLSPVEPTENRETTANEKTTPSPAEPTENG 564

Query: 207 QNEADSAPEDLHSVGTSRLLYHITDGDNPLLSPRCSIFSQSQRFNLDPESAPSPPSTQQF 266
           Q    +  +   S          T   N   +P  +  ++++    + ++ PSP    + 
Sbjct: 565 QRTPFANEKTTSSSAEPTEHGERTPLANENTTPSPAEPTENRERTANEKTTPSPAEPTE- 623

Query: 267 MMPRSSSRCSCGDGKEPQTITQLTKHIQSL----KRKIRKFEEKFEQEKKY-------RP 315
               +  R    + K   ++ + T++ Q      ++      E  E E++         P
Sbjct: 624 ----NGDRTPLANEKTTPSLAEPTENGQRTPFANEKTTSSSAEPTEHEERTPLANENTTP 679

Query: 316 SHGDKTSNPEVLKWMNDLAKGRKQLKELKLKLSEEQGSAPKGPPRNL-------LCEQPT 368
           S  + T N E     N         +  ++  +E+    P  P  N            P 
Sbjct: 680 SPAEPTENRERTANENTTPSPAGPTENREMTANEKTTLFPAEPTENRERTANEKTTSSPA 739

Query: 369 VPRENG--------KPEAAGPEPSSSGEETPDAALTCLKERREQLP--PQEDSKVTKQDK 418
            P ENG        K  ++  EP+  GE TP A      E     P  P E+ + T  +K
Sbjct: 740 EPTENGQRTPFANEKTTSSSAEPTEHGERTPLA-----NENTTLSPAGPTENRERTANEK 794

Query: 419 NL---IKPLYDRYRIIKQILSTPSLIPTIQEEEDSDEDRPQGSQQPSLADPASHLPVGDH 475
                 +P  +R R   +  +TPS  P    E             PSLA+P  +   G  
Sbjct: 795 TTPFPAEPTENRERTANE-NTTPS--PAQPTENGDRTPLANEKTTPSLAEPTEN---GKR 848

Query: 476 LTYSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRETRADKK 526
             ++NE     +  P E  E  P    ++N +  + P      RE  A++K
Sbjct: 849 TPFANEKTTSSSAEPTEHAERTP----LANENTTSSPAEPTENRERTANEK 895


>gi|151101151 coiled-coil domain containing 2 isoform b [Homo
           sapiens]
          Length = 372

 Score = 37.7 bits (86), Expect = 0.030
 Identities = 41/171 (23%), Positives = 83/171 (48%), Gaps = 31/171 (18%)

Query: 281 KEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQL 340
           +E Q++  +    Q+ +++IR  EE+ EQEK+         +  +++K M+       Q+
Sbjct: 182 RETQSLDVIFTERQAKEKQIRSVEEEIEQEKQ---------ATDDIIKNMS----FENQV 228

Query: 341 KELKLKLSEEQGSAPKGPPRNLLCEQPTVPR----ENGKPEAAGPEPSSSGEETPDAALT 396
           K L++K + E+          LL E  T+ +    +N K E+   E + S +   +A L 
Sbjct: 229 KYLEMKTTNEK----------LLQELDTLQQQLDSQNMKKESLEAEIAHS-QVKQEAVL- 276

Query: 397 CLKERREQLPPQEDSKVTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEE 447
            L E+  +L    D  +  +DK++  P+ +R +++KQI      I +++ +
Sbjct: 277 -LHEKLYELESHRDQMIA-EDKSIGSPMEEREKLLKQIKDDNQEIASMERQ 325


>gi|151101140 coiled-coil domain containing 2 isoform a [Homo
           sapiens]
          Length = 600

 Score = 37.7 bits (86), Expect = 0.030
 Identities = 41/171 (23%), Positives = 83/171 (48%), Gaps = 31/171 (18%)

Query: 281 KEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQL 340
           +E Q++  +    Q+ +++IR  EE+ EQEK+         +  +++K M+       Q+
Sbjct: 182 RETQSLDVIFTERQAKEKQIRSVEEEIEQEKQ---------ATDDIIKNMS----FENQV 228

Query: 341 KELKLKLSEEQGSAPKGPPRNLLCEQPTVPR----ENGKPEAAGPEPSSSGEETPDAALT 396
           K L++K + E+          LL E  T+ +    +N K E+   E + S +   +A L 
Sbjct: 229 KYLEMKTTNEK----------LLQELDTLQQQLDSQNMKKESLEAEIAHS-QVKQEAVL- 276

Query: 397 CLKERREQLPPQEDSKVTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEE 447
            L E+  +L    D  +  +DK++  P+ +R +++KQI      I +++ +
Sbjct: 277 -LHEKLYELESHRDQMIA-EDKSIGSPMEEREKLLKQIKDDNQEIASMERQ 325


>gi|151105223 coiled-coil domain containing 2 isoform a [Homo
           sapiens]
          Length = 600

 Score = 37.7 bits (86), Expect = 0.030
 Identities = 41/171 (23%), Positives = 83/171 (48%), Gaps = 31/171 (18%)

Query: 281 KEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQL 340
           +E Q++  +    Q+ +++IR  EE+ EQEK+         +  +++K M+       Q+
Sbjct: 182 RETQSLDVIFTERQAKEKQIRSVEEEIEQEKQ---------ATDDIIKNMS----FENQV 228

Query: 341 KELKLKLSEEQGSAPKGPPRNLLCEQPTVPR----ENGKPEAAGPEPSSSGEETPDAALT 396
           K L++K + E+          LL E  T+ +    +N K E+   E + S +   +A L 
Sbjct: 229 KYLEMKTTNEK----------LLQELDTLQQQLDSQNMKKESLEAEIAHS-QVKQEAVL- 276

Query: 397 CLKERREQLPPQEDSKVTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEE 447
            L E+  +L    D  +  +DK++  P+ +R +++KQI      I +++ +
Sbjct: 277 -LHEKLYELESHRDQMIA-EDKSIGSPMEEREKLLKQIKDDNQEIASMERQ 325


>gi|151105229 coiled-coil domain containing 2 isoform a [Homo
           sapiens]
          Length = 600

 Score = 37.7 bits (86), Expect = 0.030
 Identities = 41/171 (23%), Positives = 83/171 (48%), Gaps = 31/171 (18%)

Query: 281 KEPQTITQLTKHIQSLKRKIRKFEEKFEQEKKYRPSHGDKTSNPEVLKWMNDLAKGRKQL 340
           +E Q++  +    Q+ +++IR  EE+ EQEK+         +  +++K M+       Q+
Sbjct: 182 RETQSLDVIFTERQAKEKQIRSVEEEIEQEKQ---------ATDDIIKNMS----FENQV 228

Query: 341 KELKLKLSEEQGSAPKGPPRNLLCEQPTVPR----ENGKPEAAGPEPSSSGEETPDAALT 396
           K L++K + E+          LL E  T+ +    +N K E+   E + S +   +A L 
Sbjct: 229 KYLEMKTTNEK----------LLQELDTLQQQLDSQNMKKESLEAEIAHS-QVKQEAVL- 276

Query: 397 CLKERREQLPPQEDSKVTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQEE 447
            L E+  +L    D  +  +DK++  P+ +R +++KQI      I +++ +
Sbjct: 277 -LHEKLYELESHRDQMIA-EDKSIGSPMEEREKLLKQIKDDNQEIASMERQ 325


>gi|58530842 desmoplakin isoform II [Homo sapiens]
          Length = 2272

 Score = 37.0 bits (84), Expect = 0.050
 Identities = 56/243 (23%), Positives = 96/243 (39%), Gaps = 27/243 (11%)

Query: 284  QTITQLTKHIQSLKRKIRKFEEKFEQEKK-YRPSHGDKTSNPEVLKWMNDLAKGRKQLKE 342
            + IT+LT  I+  KR+ +  E++F+Q+K  Y      +    E L W     +  K +KE
Sbjct: 1109 EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQK--LESEKAIKE 1166

Query: 343  LKLKLSEEQGSAPKGPPRNLLCEQPTVPRENGKPEAAGPEPSSSGEETPDAALTCLKERR 402
             + ++            R LL E+ T  RE     A   + S+  +E+ +     ++ER 
Sbjct: 1167 KEYEIER---------LRVLLQEEGTRKREYENELA---KASNRIQESKNQCTQVVQERE 1214

Query: 403  EQLPPQEDSKVTKQDKNLIKPLYDRYRIIKQILSTPSLIPTIQ--EEEDSDEDRPQGSQQ 460
              L      KV +QDK  ++ L D     K  L   + +      E++    D  Q   Q
Sbjct: 1215 SLL---VKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQ 1271

Query: 461  PSLADPASHLPVGDHLTYSNETEPVRALLPDEKKEVKPPALSMSNLHEATMPVLLDHLRE 520
             S  + A      +      E   +R+ +   + E+K        + E     L D  RE
Sbjct: 1272 YSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIK-------RIEERCRRKLEDSTRE 1324

Query: 521  TRA 523
            T++
Sbjct: 1325 TQS 1327


>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
           precursor [Homo sapiens]
          Length = 513

 Score = 37.0 bits (84), Expect = 0.050
 Identities = 59/257 (22%), Positives = 104/257 (40%), Gaps = 54/257 (21%)

Query: 35  DCSSLRDENNKENYPDAGALVEEHAPPSWEPQQQNVEATVLVDSVLRPSMGNFKSRKPKS 94
           D  S+R E        AG   +E    S +   Q+   + L++    PS   F+    KS
Sbjct: 219 DPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLE---HPSRKIFR----KS 271

Query: 95  IFKAESGRSHGESQETEHVVSSQSECQVRAGTPAHESPQNNAFKCQETVRLQPRIDQRTA 154
               E  RS  +   T   V S             +S +N+    ++T   QPR D +  
Sbjct: 272 RISEEDDRSELDDNNTMEEVKS-------------DSTENS--NSRDTGLSQPRRDSK-G 315

Query: 155 ISPKDAFETRQDLNEEEAAQVHGV------------KDPAPASTQSVLADGT-DSADPSP 201
            S +D+   +++L++EE+  V G             ++ +  S + V+++   D+ DP+ 
Sbjct: 316 DSQEDS---KENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTT 372

Query: 202 VHKDGQNEADSAPED-LHSVGTSRLLYHITDGDNPLLSPRCSIFSQSQRFNLDPESAPSP 260
            + + Q ++DS+ ED  H++  S+        D+            S+  N   ES  SP
Sbjct: 373 SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADS----------ESSESLNFSEESPESP 422

Query: 261 ----PSTQQFMMPRSSS 273
                S+Q+ +   SSS
Sbjct: 423 EDENSSSQEGLQSHSSS 439



 Score = 30.4 bits (67), Expect = 4.7
 Identities = 27/117 (23%), Positives = 46/117 (39%), Gaps = 4/117 (3%)

Query: 11  DNSFSSTTVTECDEDPVSLHEDQTDCSSLRDENNKENYPDAGAL----VEEHAPPSWEPQ 66
           DN   +T+  E  ED  S  ED +   S     ++E   D+ +       E +P S E +
Sbjct: 366 DNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDE 425

Query: 67  QQNVEATVLVDSVLRPSMGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSECQVR 123
             + +  +   S    S       +       +S RS  +S  TE   SS+ + Q++
Sbjct: 426 NSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLK 482


>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
           precursor [Homo sapiens]
          Length = 497

 Score = 37.0 bits (84), Expect = 0.050
 Identities = 59/257 (22%), Positives = 104/257 (40%), Gaps = 54/257 (21%)

Query: 35  DCSSLRDENNKENYPDAGALVEEHAPPSWEPQQQNVEATVLVDSVLRPSMGNFKSRKPKS 94
           D  S+R E        AG   +E    S +   Q+   + L++    PS   F+    KS
Sbjct: 203 DPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLE---HPSRKIFR----KS 255

Query: 95  IFKAESGRSHGESQETEHVVSSQSECQVRAGTPAHESPQNNAFKCQETVRLQPRIDQRTA 154
               E  RS  +   T   V S             +S +N+    ++T   QPR D +  
Sbjct: 256 RISEEDDRSELDDNNTMEEVKS-------------DSTENS--NSRDTGLSQPRRDSK-G 299

Query: 155 ISPKDAFETRQDLNEEEAAQVHGV------------KDPAPASTQSVLADGT-DSADPSP 201
            S +D+   +++L++EE+  V G             ++ +  S + V+++   D+ DP+ 
Sbjct: 300 DSQEDS---KENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTT 356

Query: 202 VHKDGQNEADSAPED-LHSVGTSRLLYHITDGDNPLLSPRCSIFSQSQRFNLDPESAPSP 260
            + + Q ++DS+ ED  H++  S+        D+            S+  N   ES  SP
Sbjct: 357 SYVEDQEDSDSSEEDSSHTLSHSKSESREEQADS----------ESSESLNFSEESPESP 406

Query: 261 ----PSTQQFMMPRSSS 273
                S+Q+ +   SSS
Sbjct: 407 EDENSSSQEGLQSHSSS 423



 Score = 30.4 bits (67), Expect = 4.7
 Identities = 27/117 (23%), Positives = 46/117 (39%), Gaps = 4/117 (3%)

Query: 11  DNSFSSTTVTECDEDPVSLHEDQTDCSSLRDENNKENYPDAGAL----VEEHAPPSWEPQ 66
           DN   +T+  E  ED  S  ED +   S     ++E   D+ +       E +P S E +
Sbjct: 350 DNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDE 409

Query: 67  QQNVEATVLVDSVLRPSMGNFKSRKPKSIFKAESGRSHGESQETEHVVSSQSECQVR 123
             + +  +   S    S       +       +S RS  +S  TE   SS+ + Q++
Sbjct: 410 NSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQLK 466


>gi|169214011 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 186

 Score = 37.0 bits (84), Expect = 0.050
 Identities = 21/43 (48%), Positives = 26/43 (60%), Gaps = 4/43 (9%)

Query: 352 GSAPKGPPRNLLCEQPTVPRENGKPEAAGPEPSSSGEETPDAA 394
           G+ P+ PP  L    PT+P ++GK EA GPEP     ETP AA
Sbjct: 141 GAGPRTPPMTLP-SPPTLPAQDGKKEARGPEPPL---ETPLAA 179


>gi|113428768 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 186

 Score = 37.0 bits (84), Expect = 0.050
 Identities = 21/43 (48%), Positives = 26/43 (60%), Gaps = 4/43 (9%)

Query: 352 GSAPKGPPRNLLCEQPTVPRENGKPEAAGPEPSSSGEETPDAA 394
           G+ P+ PP  L    PT+P ++GK EA GPEP     ETP AA
Sbjct: 141 GAGPRTPPMTLP-SPPTLPAQDGKKEARGPEPPL---ETPLAA 179


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.127    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,462,504
Number of Sequences: 37866
Number of extensions: 1434077
Number of successful extensions: 6301
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 237
Number of HSP's that attempted gapping in prelim test: 5941
Number of HSP's gapped (non-prelim): 585
length of query: 585
length of database: 18,247,518
effective HSP length: 108
effective length of query: 477
effective length of database: 14,157,990
effective search space: 6753361230
effective search space used: 6753361230
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.