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Search of human proteins with 50897852
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
(1843 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 3540 0.0
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 3518 0.0
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 1607 0.0
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 518 e-146
gi|71061468 centromere protein E [Homo sapiens] 207 6e-53
gi|55770834 centromere protein F [Homo sapiens] 204 6e-52
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 202 2e-51
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 199 3e-50
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 199 3e-50
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 197 6e-50
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 197 6e-50
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 194 9e-49
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 194 9e-49
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 192 2e-48
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 189 2e-47
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 186 2e-46
gi|21735548 centrosomal protein 2 [Homo sapiens] 183 1e-45
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 181 6e-45
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 181 8e-45
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 180 1e-44
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 180 1e-44
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 178 4e-44
gi|4506751 restin isoform a [Homo sapiens] 177 6e-44
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 177 8e-44
gi|148746195 trichohyalin [Homo sapiens] 177 1e-43
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 176 1e-43
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 176 1e-43
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 176 2e-43
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 176 2e-43
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 176 2e-43
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 3540 bits (9180), Expect = 0.0
Identities = 1843/1843 (100%), Positives = 1843/1843 (100%)
Query: 1 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE 60
MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
Sbjct: 1 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE 60
Query: 61 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE 120
SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
Sbjct: 61 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE 120
Query: 121 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD 180
VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
Sbjct: 121 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD 180
Query: 181 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM 240
MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
Sbjct: 181 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM 240
Query: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
Query: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK 420
TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
Sbjct: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK 420
Query: 421 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
Sbjct: 421 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
Query: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
Sbjct: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
Query: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK 960
IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK
Sbjct: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK 960
Query: 961 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS 1020
LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
Sbjct: 961 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS 1020
Query: 1021 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1080
PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
Sbjct: 1021 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1080
Query: 1081 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1140
AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
Sbjct: 1081 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1140
Query: 1141 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1200
SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
Sbjct: 1141 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1200
Query: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1260
RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
Sbjct: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1260
Query: 1261 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL 1320
TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
Sbjct: 1261 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL 1320
Query: 1321 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380
EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
Sbjct: 1321 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380
Query: 1381 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ 1440
YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
Sbjct: 1381 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ 1440
Query: 1441 DSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELG 1500
DSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELG
Sbjct: 1441 DSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELG 1500
Query: 1501 AMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASL 1560
AMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASL
Sbjct: 1501 AMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASL 1560
Query: 1561 DSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKR 1620
DSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKR
Sbjct: 1561 DSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKR 1620
Query: 1621 QTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLD 1680
QTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLD
Sbjct: 1621 QTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLD 1680
Query: 1681 EVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFIS 1740
EVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFIS
Sbjct: 1681 EVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDTYFIS 1740
Query: 1741 SAGKPTPGTQGKIKLVKESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLTKD 1800
SAGKPTPGTQGKIKLVKESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLTKD
Sbjct: 1741 SAGKPTPGTQGKIKLVKESSLSRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLTKD 1800
Query: 1801 SRLPISVDSPPAAADSNTTAASNVDKVQESRNSKSRSREQQSS 1843
SRLPISVDSPPAAADSNTTAASNVDKVQESRNSKSRSREQQSS
Sbjct: 1801 SRLPISVDSPPAAADSNTTAASNVDKVQESRNSKSRSREQQSS 1843
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 3518 bits (9121), Expect = 0.0
Identities = 1841/1871 (98%), Positives = 1842/1871 (98%), Gaps = 29/1871 (1%)
Query: 1 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE 60
MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
Sbjct: 1 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE 60
Query: 61 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE 120
SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
Sbjct: 61 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE 120
Query: 121 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD 180
VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
Sbjct: 121 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD 180
Query: 181 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM 240
MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
Sbjct: 181 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM 240
Query: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
Query: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK 420
TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
Sbjct: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK 420
Query: 421 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
Sbjct: 421 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
Query: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
Sbjct: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
Query: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK 960
IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD RYKLLESK
Sbjct: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD-RYKLLESK 959
Query: 961 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS 1020
LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
Sbjct: 960 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS 1019
Query: 1021 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1080
PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
Sbjct: 1020 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1079
Query: 1081 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1140
AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
Sbjct: 1080 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1139
Query: 1141 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1200
SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
Sbjct: 1140 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1199
Query: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1260
RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
Sbjct: 1200 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1259
Query: 1261 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL 1320
TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
Sbjct: 1260 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL 1319
Query: 1321 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380
EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
Sbjct: 1320 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379
Query: 1381 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ 1440
YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
Sbjct: 1380 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ 1439
Query: 1441 DSSSVGSNSLEDGQTLGTKKSS----------------------------TMNDLVQSMV 1472
DSSSVGSNSLEDGQTLGTKKSS +MNDLVQSMV
Sbjct: 1440 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV 1499
Query: 1473 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT 1532
LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
Sbjct: 1500 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT 1559
Query: 1533 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS 1592
SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
Sbjct: 1560 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS 1619
Query: 1593 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV 1652
HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
Sbjct: 1620 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV 1679
Query: 1653 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP 1712
VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
Sbjct: 1680 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP 1739
Query: 1713 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA 1772
GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
Sbjct: 1740 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA 1799
Query: 1773 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN 1832
TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
Sbjct: 1800 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN 1859
Query: 1833 SKSRSREQQSS 1843
SKSRSREQQSS
Sbjct: 1860 SKSRSREQQSS 1870
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 1607 bits (4160), Expect = 0.0
Identities = 876/1766 (49%), Positives = 1230/1766 (69%), Gaps = 54/1766 (3%)
Query: 9 LLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQRVNKKV 68
LLE F+ SPLVTWVKTFGP +G+ NL Y+ LVDG+FLNQ+MLQI+P+ +QR+NK V
Sbjct: 8 LLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQRINKHV 67
Query: 69 NNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLL 128
NND +LR+ NL+ILVR IK YYQE LQQLI+M+LPNVL+IG++P S + EE+KK+LLL+
Sbjct: 68 NNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEIKKVLLLV 127
Query: 129 LGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEP 188
LGCAVQC++KEEFIERI+ LD +T+A + AHIQEVTHNQENVFDLQW+E+ D++ E++E
Sbjct: 128 LGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEA 187
Query: 189 LLKNMALHLKRLIDERDEHSETIIELSEERDGLHFL----PHASSSAQSPCGSPGMKRTE 244
L ++M LHL+RLID+RDE +E I++L++ERD L P SSSA S +E
Sbjct: 188 LSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSE 247
Query: 245 SRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARS 304
+QHL+VELAD KA++RR+RQELE+KTEQL+D + E++Q+ +EL++++QEN+ L +DARS
Sbjct: 248 DKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARS 307
Query: 305 ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
AR YRDELD+LREKA RV++LE E++R KE+LHD++FYKAR+EEL+EDN +L+ETK MLE
Sbjct: 308 ARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLE 367
Query: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
+QL RAR DK+HELEKENLQLK+KLHD+E++RD D+K+IEEL+EENM LE+AQKQSM+
Sbjct: 368 EQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMN 427
Query: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
ES HLGWELEQ+S+ ++LS+A +KS E+NE SSR+LKLE ENQSL T++ LR
Sbjct: 428 ESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASL 487
Query: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
+E + K ++EKEN +LSKK+E L+ ++ +EKQS Q+ + LS++L++EK QL+ +ET
Sbjct: 488 VLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMET 547
Query: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
L+ + RQIK LEQE +HLN+ + SLR+RSQ+S+EAR+KD+EKENK LH+++ E + KLS
Sbjct: 548 LKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLS 607
Query: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664
++EFEKRQ+ ++LE KEKGERAE+LE EL L++EN L +K+T+L+ EK+EALE E
Sbjct: 608 QLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHE 667
Query: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ 724
+ L+ ENR L+K+LD+ +N++ QLE LE++N QLD ENLELRR VE+++ S K+AQ++
Sbjct: 668 SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
Query: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
EN++LE EKE+L+K ++LLKA KK+ERLE+SYQ + EN RLQ++LE+S+ K Q LES
Sbjct: 728 RENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLES 787
Query: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
EL +LE E Q L+++LE L++++ +LE EK+ K+LEQE +QLEKDKK LEKE KRL QQ
Sbjct: 788 ELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQ 847
Query: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
E+KD L+++ K+ +EKE++ L KE+ +++ +LKELEK+N++L K+ T+ +TL
Sbjct: 848 VELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTL 907
Query: 905 VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST 964
TLREDLV EKLK+QQ++++L+KL+ ELEK+GLN+E LL ++ S D++YK+LE + ES
Sbjct: 908 TTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESA 967
Query: 965 LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS---- 1020
LK +L +KEEKI LEA++EE + N+QL EL+ +KK E L+Q Q E + +Q+S
Sbjct: 968 LKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHP 1027
Query: 1021 --PPISGEDNK--WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN 1076
+ K W +E T ELL+VKDR IE+ERNNA LQAEKQ LK QL+ LETQN
Sbjct: 1028 AGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQN 1087
Query: 1077 NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1136
+QIL LQ+Q+ LQE NTTLQTQ AKLQVENSTL+SQS +L Q L ++ E
Sbjct: 1088 VTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKE 1147
Query: 1137 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1196
ENES+ +++E L + Y++L++DHE L LHERQ++EYE+LI +H LK+ H+NLE+EH+
Sbjct: 1148 TENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHK 1207
Query: 1197 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1256
+L +R+ +LK+K +LE+ EK+L E+E + E + + E ++L GE DR+N + Q
Sbjct: 1208 ELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ 1267
Query: 1257 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL 1316
L E E L K LK+ LNN++LE R +A F +LKEQ+Q +DI+ TKL+N CELLS+L
Sbjct: 1268 LKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRL 1327
Query: 1317 KGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
KGNLEEEN HLL QIQ L QN+ LLEQNME+K+ +H EQ+QYIDKLN LRR KEKLEEK
Sbjct: 1328 KGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEK 1387
Query: 1377 IMDQYKFYDPSPPRRRGNWITLK-MRKLIKSKKDINRERQKSLTLTP----TRSDSSEGF 1431
IMDQYKFYDP PP+++ +WI K + KLIK KK+ +RER KS +P SD +
Sbjct: 1388 IMDQYKFYDP-PPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPA 1446
Query: 1432 LQLP---HQDSQDSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEVPD 1488
P ++ D+ ++GSN E+ DL GS + +
Sbjct: 1447 ASQPLRSQAENPDTPALGSNCAEERDAHNGSVGKGPGDLKPKR--GSPHRGSLDRTDAST 1504
Query: 1489 DISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSST 1548
D++ ELG+ ST+A + NS+ R K S +++ + +
Sbjct: 1505 DLAMRSWPSELGSRTCSTSATTTAPSNSTPIARHPG--RTKGYNSDDNLCEPSL-EFEVP 1561
Query: 1549 GSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEAWS 1608
R + SRP+SL+S R N+++N+S +K + R +S SS + D
Sbjct: 1562 NHRQYVSRPSSLESSR----NTSSNSSPLNLKGSSEQLHGRSESFSSEDLIPSRDLATLP 1617
Query: 1609 SSGSSPIQYLKRQ-----TRSSPVLQHKISETLESRHH---KIKTGSPGSEVVTLQQFLE 1660
S+P + + R+ P+ Q + + + + + SP SE+VTL++FLE
Sbjct: 1618 REASTPGRNALGRHEYPLPRNGPLPQEGAQKRGTAPPYVGVRPCSASPSSEMVTLEEFLE 1677
Query: 1661 ESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPGDFY---- 1716
ESN+ + S +++LL + + S G+ P A+ K P +F
Sbjct: 1678 ESNRSSPTHDTPSCRDDLLSDYFRKASDPPAIGGQPGPP----AKKEGAKMPTNFVAPTV 1733
Query: 1717 -------DRRTTKP-EFLRPGPRKTE 1734
+ R KP ++++P R TE
Sbjct: 1734 KMAAPTSEGRPLKPGQYVKPNFRLTE 1759
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 518 bits (1334), Expect = e-146
Identities = 418/1440 (29%), Positives = 716/1440 (49%), Gaps = 155/1440 (10%)
Query: 8 PLLEQFMTSPLVTWVKTFGPLAA----GNGTNLDE-----------YVALVDGVFLNQVM 52
P L F++ L TW L G +E ++ L DG L +V+
Sbjct: 7 PRLRDFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEEPPLWLEKRFLRLSDGALLLRVL 66
Query: 53 LQINPKLES-QRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKN 111
I P R+ + ++ A+ R+ NL+ L +++ +YQE LQ LI+ P++ +G +
Sbjct: 67 GIIAPSSRGGPRMLRGLDGPAAWRVWNLNHLWGRLRDFYQEELQLLILSPPPDLQTLGFD 126
Query: 112 PFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENV- 170
P SE+ E+++ +L LLLG +VQC+ +E FI IQGL + ++ +AA IQEVT V
Sbjct: 127 PLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVV 186
Query: 171 FDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSS 230
L + +++ ++E L +++ L +L ERD ++ + EL ER+ L P A S
Sbjct: 187 LALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSR 246
Query: 231 AQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKR 290
A P P HL+++LA+AKA++RRLRQELEEK E LLD + E++ +E E++R
Sbjct: 247 A--PAEGPS-------HHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRR 297
Query: 291 LQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350
L+QE L A+ A +YR+E +ALRE+A R+ +L+ E+ R +ERL E YK+++EE +
Sbjct: 298 LRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEER 357
Query: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410
+ VL +K +LE+QLE R R +LHE ++ENL L+ +L + E D R ++++L E
Sbjct: 358 VLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAE 417
Query: 411 ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP----QKSLGHEVNELTSSRLLKLE 466
EN+ LE+ ++S++ EAP SL EV E + RL LE
Sbjct: 418 ENVELELELQRSLEPP------------PGSPGEAPLAGAAPSLQDEVREAEAGRLRTLE 465
Query: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526
EN+ L ++ L+ G +L+ +E+ L E + + + S Q
Sbjct: 466 RENRELRGLLQVLQ----GQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFD-HSPQGLVQ 520
Query: 527 LSKDLMKEKAQL-EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS------AE 579
++D + L ++++ E S + + + + + + Q S +
Sbjct: 521 KARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESG 580
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK-KELEHYKEKGERAE--ELENELHH 636
+ V+ E K S ++ + ++ + +I+ +L + +G A EL E
Sbjct: 581 SPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWG 640
Query: 637 LEKENELLQKKITNLKITCEKIEALEQENSEL-----ERENRKLKKTLDSFKNLTFQLES 691
L +E + K + + ++E E N L + E R+ + L+ +
Sbjct: 641 LRQEGP--EHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKP 698
Query: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
+K L+ + E ESL + L+ E +L + E L LE A +K
Sbjct: 699 QQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELE---AQARKL 755
Query: 752 ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811
E + E RL K L + + + E + E L+ E ++ + + LE
Sbjct: 756 E-------AQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLR---EAVEAAGQELE 805
Query: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
+E ++L + + ++++Q E+E RLR Q+E + ++ LE E +
Sbjct: 806 SASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQV-------LESEGRQ--- 855
Query: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931
L+E E+E +E K A L+ +L ++ +++ LE L E
Sbjct: 856 ----------HLEEAERERRE--KEA---------LQAELEKAVVRGKELGARLEHLQRE 894
Query: 932 LEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 991
LE+ L ++ L +++S RY+ LE +LE+ L+ + KEE + L+ R
Sbjct: 895 LEQAALERQEFLREKES-QHQRYQGLEQRLEAELQAAATSKEEALMELKTRA-------L 946
Query: 992 QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1051
QL +EL +++ L ++ E + + + RLIEV
Sbjct: 947 QLEEELFQLRQGPAGLGPKKRAEPQLVETQNV-----------------------RLIEV 983
Query: 1052 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1111
ER+NA L AEK AL+ QL+ LE Q +LQ + L Q+ QE ++ LQ + + L+++
Sbjct: 984 ERSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQG 1043
Query: 1112 STLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQA 1171
L+ + LE E + + +E+ + +L++DH+ L L RQ
Sbjct: 1044 QELHR--------------KLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQE 1089
Query: 1172 SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK 1231
+E E L+ +H LK+ + LE+ HR+L+ R+ QL Q+ +E E L E+E+++ +
Sbjct: 1090 AELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGH 1149
Query: 1232 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1291
+ E ++L E+DR ++L +E LQ + L+ L +LE+ +LE + +
Sbjct: 1150 RQRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQ 1209
Query: 1292 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1351
L+E QQLD+++ +L QCELL+QL+ EEENR LL ++Q L +NR LLE+++ES+D
Sbjct: 1210 LRESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDH 1269
Query: 1352 FHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSP-PR-RRGNWITLKMRKLIKSKKD 1409
H EQR+Y+D+LN LRR+K+KL EKIMDQY+ +P P PR ++G+W+ K+++L++ +++
Sbjct: 1270 LHREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 207 bits (528), Expect = 6e-53
Identities = 271/1269 (21%), Positives = 561/1269 (44%), Gaps = 158/1269 (12%)
Query: 237 SPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRL----- 291
S ++ E + L+ + I+ + +LE K + +D ++EL+ E+ +L
Sbjct: 646 SENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLID 705
Query: 292 ----QQENMNLLSDARSARMYR------DELDALREKAVRVDKLESEVSRYKERLHDIEF 341
+ NL + + + + +E +ALRE+ + + +L+S S ++E
Sbjct: 706 GKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPS-------EVER 758
Query: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD 401
+ +++ E+ ++ K L ++ +R L E E + K L +
Sbjct: 759 LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLE---EIGKTKDDLATTQSNYKST 815
Query: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR 461
++ + +M E K ++E+ + E+ +S+ ++ ++ SLG EL S +
Sbjct: 816 DQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS---SLGALKTEL-SYK 871
Query: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSL 521
+L+ + + + + + E+ + +E S + +E+E +++K++ E+ Q
Sbjct: 872 TQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEK 931
Query: 522 QNCQNLSKDLMKEKAQLEKTI-ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
+ + L + L E+ QL+ I +T+ N + Q E L + SL+Q +
Sbjct: 932 DDLKQLQESLQIERDQLKSDIHDTVNMNIDTQ--------EQLRNALESLKQHQETINTL 983
Query: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQI----KKELEHYKEKGERAEELENE--- 633
+ K E+ ++ LH E ++ +K EF+++ + K++LE + A+ +NE
Sbjct: 984 KSKISEEVSRNLH---MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIE 1040
Query: 634 ----LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQL 689
+ L +E LQ+ + ++ E+++ +EN E+ EN++ + L L Q
Sbjct: 1041 QQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGD--ELKKQQ 1098
Query: 690 ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
E + +E + ++ EL R + L K+ + ++++L+ +++QL E + K
Sbjct: 1099 EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKE---KSQQLQEKQQQLLNVQEEMSEMQK 1155
Query: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR 809
K +E L+ L+N ++ +E+E +L Q L +N EE+K +K
Sbjct: 1156 KINEIE-----------NLKNELKNKELTLEHMETERLELA---QKLNENYEEVKSITKE 1201
Query: 810 LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
+ L++ KS E E L +++E + +++ +I L+E+ I L +
Sbjct: 1202 RKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEK 1261
Query: 870 SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL--VSEKLKTQQMNNDLEK 927
+ +I + ++LEK + +L + +I L +E L V E +TQ+ N+LE
Sbjct: 1262 TAQI-------INTQDLEKSHTKLQE----EIPVLHEEQELLPNVKEVSETQETMNELEL 1310
Query: 928 LTHE--------LEKIGLNKERLLHDEQSTDDSRYKLLESKLE-STLKKSLEIK----EE 974
LT + L +I + + RL Q + + L + + T+K++LE+K +E
Sbjct: 1311 LTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKE 1370
Query: 975 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED------N 1028
I A+++ES + + Q L +K+ E K + E+ + + +
Sbjct: 1371 HIRETLAKIQESQSKQE---QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLS 1427
Query: 1029 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ-----LETQNN------ 1077
K +ES + + + K KD +++R LQ+E LK +K+ LET+
Sbjct: 1428 KRLQESHDEMKSVAKEKD---DLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHC 1484
Query: 1078 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1137
L+ Q + V+L E+ T + T +L+ N L ++ + + Q I+Q S
Sbjct: 1485 CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544
Query: 1138 ENESVIKEREDLKSLYDSLIKDHEK--LELLHERQAS--EYESLISKHGTLKSAHKNLEV 1193
E + +K+ ++ + DS ++ E LEL + Q S E + +I + +K + L++
Sbjct: 1545 EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQI 1604
Query: 1194 EH--------------RDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAE 1239
E ++ +++ Q LK E EKM ++E K + ET
Sbjct: 1605 ERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLK-----EQFETQKLN 1659
Query: 1240 YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAE----FSKLKEQ 1295
+ + EN RL + L+E + + +L+S+ K+E+ +L+ ++ E+
Sbjct: 1660 LENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEK 1719
Query: 1296 YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV- 1354
++L I L E + +L+G + E+ + + + L N L Q+++ ++ +
Sbjct: 1720 QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIA 1779
Query: 1355 -----EQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKM--RKLIKSK 1407
EQ++ IDKL + +K +K+ + K + S + + LK +LI K
Sbjct: 1780 HMHLKEQQETIDKLRGIVSEK---TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK 1836
Query: 1408 KDINRERQK 1416
KD+N ++K
Sbjct: 1837 KDVNETQKK 1845
Score = 203 bits (517), Expect = 1e-51
Identities = 270/1303 (20%), Positives = 558/1303 (42%), Gaps = 172/1303 (13%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
TD ++ + L + K +++E + ++ I+ LS+E A + S
Sbjct: 815 TDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELS----- 869
Query: 239 GMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQE-------LEQMEIELKRL 291
+T+ Q + E+ + ++ +L+++LE + L ++E L+Q E+K L
Sbjct: 870 --YKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTL 927
Query: 292 QQENMNLLSDARSARMYRDEL-----DALREKAVRVDKLESEVSRYKERLHDIEFYKARV 346
QE +L S ++ RD+L D + ++L + + K+ I K+++
Sbjct: 928 TQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKI 987
Query: 347 EELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-LKAKLHDMEMERDMDRKKI 405
E N + E +D+ + DK +LE +N Q L A + D E+ ++KI
Sbjct: 988 SEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIE--QQRKI 1045
Query: 406 EELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465
L++E L+ + + E L +L++ +++
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQLKTDLKE--------------------------NIEM 1079
Query: 466 EMENQSLTKTV-EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
+ENQ + + +EL+ + V + +K E E R ++ +E ++ ++ Q LQ
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
Q ++ +E ++++K I + EN + ++K E EH+ L Q+ + E VK
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEI-ENLKNELKNKELTLEHMETERLELAQKLNENYE-EVKS 1197
Query: 585 IEKENKILHESIKETSSK-------LSKIEFEKRQIKKELE----HYKEKGERAEE---- 629
I KE K+L E K ++ + +IE Q K+EL+ H KE E +E
Sbjct: 1198 ITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRS 1257
Query: 630 --------------------LENELHHLEKENELLQ--KKITNLKITCEKIEALEQENS- 666
L+ E+ L +E ELL K+++ + T ++E L ++++
Sbjct: 1258 VSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTT 1317
Query: 667 ---------ELE--RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKC 715
E+E R N K +++ + K+LT + ++L+ L+ ++ +L+ ++
Sbjct: 1318 KDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLA 1377
Query: 716 ---ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
S + L KE ++E ++ +E K R+E+ G L K L
Sbjct: 1378 KIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLG-------LSKRL 1430
Query: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL--EQLEKEN---------KSLE 821
+ S+ +++ + E DL+ + LQ ++LK + K + + LE E K E
Sbjct: 1431 QESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQE 1490
Query: 822 QETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCV 881
+ ++L + + E E +++Q E + L+ +I EKE + K+I +E
Sbjct: 1491 ETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEI--YEKEEQFNIKQISEVQEKVN 1548
Query: 882 RLKELEKENK------ELVKRATIDIKTLVTLREDLVSEKLK-TQQMNNDLEKLTHELEK 934
LK+ ++ K + ++ +++ + ++ + +K ++M E L E ++
Sbjct: 1549 ELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQ 1608
Query: 935 IGLNKERLLHDEQSTDDSRYKLLE-SKLESTLKKSLEIK--EEKIAALEARLEESTNYNQ 991
+ N + ++ + + + Y+ L+ + + T +K EI+ +E+ + LE N
Sbjct: 1609 LKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENI 1668
Query: 992 QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLK-------- 1043
+L Q L + ++ + +D+ R V+ + + + K E + TR+L K
Sbjct: 1669 RLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLK-ENLRETITRDLEKQEELKIVH 1727
Query: 1044 --VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT----VSLQEQN 1097
+K+ +++ + + + K LE N+ L+AQ L +Q + + L+EQ
Sbjct: 1728 MHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQ 1787
Query: 1098 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1157
T+ + + L++ L N NA+L + L+ +I ++D+ +
Sbjct: 1788 ETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVS 1847
Query: 1158 KDHEKLELLHERQASEYESLISKHGTLKSAHKNLE-----VEHRDLEDRYNQLLK-QKGQ 1211
+ + + + ++ + + I + H+NLE ++ RD R + LK ++ Q
Sbjct: 1848 EMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQ 1907
Query: 1212 LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL 1271
L++ + K ++ E K ++ E+K+ D+L S+ + +Q D
Sbjct: 1908 LKESLQETKARDLEIQQELKTARMLSKEHKETV---DKLREKISEKTIQISDIQKDLDKS 1964
Query: 1272 KSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQI 1331
K L E + E + ++KE ++++ K+N + QLK E +N +
Sbjct: 1965 KDELQKKIQELQKKELQLLRVKE---DVNMSHKKINE----MEQLKKQFEAQNL----SM 2013
Query: 1332 QTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLE 1374
Q++ + N L ++ ES + E R + +ELRR KE L+
Sbjct: 2014 QSVRMDNFQLTKKLHESLE----EIRIVAKERDELRRIKESLK 2052
Score = 197 bits (500), Expect = 1e-49
Identities = 312/1447 (21%), Positives = 607/1447 (41%), Gaps = 253/1447 (17%)
Query: 159 HIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEER 218
+++EV+ QE + +L+ + T+ S L + + RL ++ E E I L++ER
Sbjct: 1294 NVKEVSETQETMNELELL--TEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKER 1351
Query: 219 DGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQEL--EEKTEQLLD 276
D L + A +K + ++H+ LA + + Q L +EK +
Sbjct: 1352 DNLKTIKEALE----------VKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTK 1401
Query: 277 CKQELEQ----------MEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLE 326
E+EQ +EIE+ L + + +S +D+L L+E L+
Sbjct: 1402 IVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEV------LQ 1455
Query: 327 SEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ 386
SE + KE + +I V + E + L L++Q E L E E E
Sbjct: 1456 SESDQLKENIKEI------VAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIST 1509
Query: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
++ +L E D + KI+E+ E+ + Q + E ++ EL+Q + ++
Sbjct: 1510 IQKQL---EAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVN---ELKQFKEHRKAKDSA 1563
Query: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV-------DSVEGNASKILKMEKE 499
+S+ ++ ELT+ RL + + E Q + K EE++ D ++ N +I+ KE
Sbjct: 1564 LQSIESKMLELTN-RLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKE 1622
Query: 500 NQRLSKKVEILENEIVQEKQS-LQNCQNLSKDLMKEKAQLEKTIET--------LRENSE 550
+Q K+ + L+ V E Q + ++L + +K LE IET L EN E
Sbjct: 1623 SQE--KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN-IETENIRLTQILHENLE 1679
Query: 551 RQIKILEQENEHLNQTVSSLR-QRSQISAEAR---VKDIEKEN--KILHESIKE---TSS 601
+++ + +E + L +L+ +R Q+ R +D+EK+ KI+H +KE T
Sbjct: 1680 -EMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETID 1738
Query: 602 KLSKIEFEKRQ----IKKELEHYKEKGERAE-ELENELH----HLEKENELLQKKITNLK 652
KL I EK ++K+LEH + + + +++ EL HL+++ E + K
Sbjct: 1739 KLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKL---RG 1795
Query: 653 ITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712
I EK + L +LE N KL++ + K QL +L+K+ ++ ++ E+ + +
Sbjct: 1796 IVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQ 1855
Query: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
+K S+ +++L++EN L ++L + LE +K+ K+ + L + L +E +L+++L
Sbjct: 1856 IKDQSLTLSKLEIENLNLA---QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESL 1912
Query: 773 ENSNKKIQQLESELQ--------------------------------DLEMENQTLQKNL 800
+ + + +++ EL+ DL+ LQK +
Sbjct: 1913 QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKI 1972
Query: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN--------------KRLRQQAE 846
+EL+ +L +++++ ++ +++E+ KKQ E +N K+L + E
Sbjct: 1973 QELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLE 2032
Query: 847 --------------IKDTTLEENNVKIGNL------EKENKTLSKEIGIY---------- 876
IK++ E + I L +++N + E +
Sbjct: 2033 EIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTES 2092
Query: 877 -KESCVRLKELEKENKEL------VKRATIDIKTLVTLREDLVSEKLKTQQ-----MNND 924
+E C R+KEL K E+ + R ++D++ + +++L S ++K
Sbjct: 2093 LREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKEL-SMRVKANLSLPYLQTKH 2151
Query: 925 LEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE 984
+EKL ++ + R++ + K+ E + ES K ++ +E E ++
Sbjct: 2152 IEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIK 2211
Query: 985 ESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN--KWERESQETTRELL 1042
Q L+Q+ + LK Q+ + ++ E + E Q+
Sbjct: 2212 I-----QHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRK 2266
Query: 1043 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTT--- 1099
++ L E ++ K ++ + ++ NN +I+A+ ++ +E++ T
Sbjct: 2267 EMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISK 2326
Query: 1100 --------LQTQNAKLQVENSTLNSQ--------STSLMNQNAQLLIQQSSLENEN---- 1139
L+ +N KL TL + T+ N+N + + + L E
Sbjct: 2327 EWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIREL 2386
Query: 1140 -ESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDL 1198
S+ + +E +IK ++LE+ ++ A + + L+ + ++V L
Sbjct: 2387 ENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQV----L 2442
Query: 1199 EDRYNQLLKQ-KGQLEDLE-KMLKVEQEKMLLENKNHETVAA-----EYKKLCGENDRLN 1251
+D+ K K ++EDL+ K++K++ EKM + + ++A EY+K R N
Sbjct: 2443 QDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLREN 2502
Query: 1252 HTYSQLLKETEVL------QTDHKNL-----KSLLNNSKL-----EQTRLEAEFSKLKEQ 1295
SQ ++T V+ Q +K L ++ N+K E RLE E SKLK+Q
Sbjct: 2503 LRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQ 2562
Query: 1296 YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVE 1355
+QL + + ELLS N+HL ++++T + RTL E+ E
Sbjct: 2563 NEQL------IKQKNELLS--------NNQHLSNEVKT--WKERTL---KREAHKQVTCE 2603
Query: 1356 QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQ 1415
K+ +K+++ + DP P + K + S +
Sbjct: 2604 NSPKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSPHPVRYFDN 2663
Query: 1416 KSLTLTP 1422
SL L P
Sbjct: 2664 SSLGLCP 2670
Score = 178 bits (451), Expect = 5e-44
Identities = 264/1319 (20%), Positives = 584/1319 (44%), Gaps = 168/1319 (12%)
Query: 137 KKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQ-----EDIEPLLK 191
KKE + R + + + Q++ Q+ + ++Q E+++M + E+++ LK
Sbjct: 1110 KKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQ-EEMSEMQKKINEIENLKNELK 1168
Query: 192 NMALHLKRLIDER-------DEHSETIIELSEERDGLHFLPHASSSAQS-------PCGS 237
N L L+ + ER +E+ E + +++ER L L + + + +
Sbjct: 1169 NKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEA 1228
Query: 238 PGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE------QMEIELKRL 291
G++ E + + L + + I LR+ + EKT Q+++ Q+LE Q EI +
Sbjct: 1229 TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINT-QDLEKSHTKLQEEIPVLHE 1287
Query: 292 QQENMNLLSDARSARMYRDELDALREKAVRVD-----KLESEVSRYKERLHD----IEFY 342
+QE + + + + +EL+ L E++ D ++E E R E+ + I+
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL 1347
Query: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHD---MEMERD 399
+ LK + L L++ + T A+ + ++++L +K K ++ + E +
Sbjct: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEME 1407
Query: 400 MDRKKIEELME---ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE 456
+ K L+ E + L ++S DE + E + + R E+ ++ L + E
Sbjct: 1408 QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKE 1467
Query: 457 LTSSRLL---KLEMENQSLTK---TVEELRTTVDSVEGNASKILK-MEKENQRLSKKVEI 509
+ + L +L++ + L + T+ ELR + E S I K +E N +L K++
Sbjct: 1468 IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE 1527
Query: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569
+ EK+ N + +S+ ++EK K + R+ + ++ +E + L +
Sbjct: 1528 -----IYEKEEQFNIKQISE--VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQE 1580
Query: 570 LRQRSQISAEAR--VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG-ER 626
++ QI + + +K +++ +I + +KE + ++ + K +KE + K
Sbjct: 1581 SQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEI--VAKMKESQEKEYQFLKMTAVNE 1638
Query: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT 686
+E E+ HL+++ E + + N++ ++ + EN E E R + K D +++
Sbjct: 1639 TQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE---EMRSVTKERDDLRSVE 1695
Query: 687 FQLESLEKENSQLDEENLE-LRRNVES---LKCASMKMAQLQL-----------ENKELE 731
E+L+ E QL E E + R++E LK M + + Q + E+
Sbjct: 1696 ---ETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEIS 1752
Query: 732 SEKEQLKKGLELLKAS-FKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790
+ ++ L+ + LKA K E L +++ L + + + K ++K +L + +DLE
Sbjct: 1753 NMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLE 1812
Query: 791 MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850
N LQ+ ++ELK + +L L+K+ +++ S++E+ KKQ++ ++ L +
Sbjct: 1813 NSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTL--------S 1864
Query: 851 TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL-VTLRE 909
LE N+ + EN K + +++ R++E K ++ +K + + K + +++
Sbjct: 1865 KLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQ 1924
Query: 910 DLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSL 969
+L + ++ +++ ++KL ++ + K + D Q D L+ K++ KK L
Sbjct: 1925 ELKTARMLSKEHKETVDKLREKISE----KTIQISDIQKDLDKSKDELQKKIQELQKKEL 1980
Query: 970 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1029
++ R++E N + + E++ +KK +EA + +QS + + K
Sbjct: 1981 QL---------LRVKEDVNMSHKKINEMEQLKKQFEA------QNLSMQSVRMDNFQLTK 2025
Query: 1030 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQL---ETQNNNLQAQILAL 1086
ES E R + K +D E+ R +L+ E+ L+++ + QN+ ++ + L
Sbjct: 2026 KLHESLEEIRIVAKERD---ELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLL 2082
Query: 1087 ----QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1142
Q T SL+E+ + ++ +L S ++ L N L + +E + E
Sbjct: 2083 SDGQQHLTESLREKCSRIK----ELLKRYSEMDDHYECL---NRLSLDLEKEIEFQKELS 2135
Query: 1143 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRY 1202
++ + +L SL K EKL ++R + E+ ++ K + S ++ E + +++
Sbjct: 2136 MRVKANL-SLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKF 2194
Query: 1203 NQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE 1262
+++ + +VE++K LL H + S+ L++ +
Sbjct: 2195 -----------EMDFIDEVEKQKELLIKIQHLQQDCDVP-------------SRELRDLK 2230
Query: 1263 VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQL--------DITSTKLNNQCELLS 1314
+ Q +++ +L + E+EF +K ++QQ+ LN + + +
Sbjct: 2231 LNQNMDLHIEEILKDFS------ESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFD-IE 2283
Query: 1315 QLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKL 1373
+LK +++EN + + ++ ++ E ++ +++ L L+ + EKL
Sbjct: 2284 KLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKL 2342
Score = 172 bits (436), Expect = 3e-42
Identities = 261/1276 (20%), Positives = 570/1276 (44%), Gaps = 203/1276 (15%)
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ----------------EN 295
E++ +A ++R R+E+ + +QL + E +E +L Q EN
Sbjct: 337 EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN 396
Query: 296 MNLLSDARSARMYRDELDALREKAV-----RVDKLESEVSRYKERLH-----DIEFYKAR 345
+ + S+ + EL A R++ V +++K+++ S Y ++ + + +K
Sbjct: 397 LTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKN--SNYADQFNIPTNITTKTHKLS 454
Query: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELE---------KENLQLKAKLHDMEM 396
+ L+E ++ + + + L D L E+E +EN++ ++L+ +
Sbjct: 455 INLLREIDESVCSESDVFSNTL-------DTLSEIEWNPATKLLNQENIE--SELNSLRA 505
Query: 397 ERDMDRKKIEELM--EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEV 454
+ D E+L +E M L++ +K +DE E + R ++ + Q L HE+
Sbjct: 506 DYDNLVLDYEQLRTEKEEMELKLKEKNDLDE-------FEALERKTKKDQEMQ--LIHEI 556
Query: 455 NELTS----SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQR--LSKKVE 508
+ L + + + ++EN+ L+ VE LR D ++ I + EN + LS +E
Sbjct: 557 SNLKNLVKHAEVYNQDLENE-LSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLE 615
Query: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
+E+ Q KQ+L + + ++ D +E A L EN E + K+ E +
Sbjct: 616 SIEDP-KQMKQTLFDAETVALDAKRESAFLRS------ENLELKEKMKELATTYKQMEND 668
Query: 569 SLRQRSQISAEARVK-DIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA 627
+SQ+ A+ +++ D+EKE L + E + S I+ ++ K+L E +
Sbjct: 669 IQLYQSQLEAKKKMQVDLEKE---LQSAFNEITKLTSLID---GKVPKDLLCNLELEGKI 722
Query: 628 EELENELHHLEKENELLQKKI---TNLKITCEKIEALEQE----NSELERENRKLKKTLD 680
+L+ EL+ +ENE L++++ + LK ++E L +E + EL + K
Sbjct: 723 TDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFS 782
Query: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESL--KCASMKMAQLQLENKELESEKEQLK 738
+ +++ L +E + ++ + N +S + + K + E K +E +
Sbjct: 783 EVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENER 842
Query: 739 KGLELLKASFKKTERLEVSYQGLDIE----NQRLQKTLENSNKKIQQLESELQDLEMENQ 794
E++ S K+ ++ + S L E Q LQ+ +++ ++E + LE +
Sbjct: 843 MNQEIVNLS-KEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDS 901
Query: 795 TLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT---- 850
TLQ E + +++L+Q +E K+L QE L++ ++ L+ E +L+ ++I DT
Sbjct: 902 TLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLK--SDIHDTVNMN 959
Query: 851 --TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKE-----------LVKRA 897
T E+ + +L++ +T++ E R +E+ E + K+
Sbjct: 960 IDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQ 1019
Query: 898 TIDIKTLVTLREDLVSEKLKTQQ-----MNNDLEKLTHELEKIGLNKERLLHDEQST--- 949
++ K TL D+ ++ QQ + + +L LE + KE+L D +
Sbjct: 1020 DLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM 1079
Query: 950 ---DDSRYKLLESKLES-----------TLKKSLEIKE--EKIAALEARLEESTNYNQQL 993
+ +LL +L+ +KK E+ +++A +E +L+E + Q+
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 994 RQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVER 1053
+Q+L V++ ++++ +E +++ ++ + E ET R L++ +L E
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNEL----KNKELTLEHMETER--LELAQKLNENYE 1193
Query: 1054 NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1113
++ E++ LK K ET+ ++L+ I ++ + +E+ L+ + L+ T
Sbjct: 1194 EVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEE---LKIAHIHLKEHQET 1250
Query: 1114 LNSQSTSLMNQNAQLL----IQQSSLENENE-SVIKEREDLKSLYDSLIKDHE---KLEL 1165
++ S+ + AQ++ +++S + + E V+ E ++L + + E +LEL
Sbjct: 1251 IDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELEL 1310
Query: 1166 LHERQAS-------------------------EYESLISKHGTLKSAHKNLEVEHRDLED 1200
L E+ + E +SL + LK+ + LEV+H L++
Sbjct: 1311 LTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKE 1370
Query: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHET--VAAEYKKLCGENDRLNHTYSQLL 1258
+ L + +++ +++ + ++ K++ET + +E ++ ++ L ++L
Sbjct: 1371 HIRETLAK------IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML 1424
Query: 1259 KETEVLQTDHKNLKSLL---NNSKLEQTRLEAEFSKLKEQY-----------QQLDITST 1304
++ LQ H +KS+ ++ + Q L++E +LKE ++L +
Sbjct: 1425 GLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHC 1484
Query: 1305 KLNNQCELLSQLKGNLEEENRH---LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYI- 1360
L Q E +++L+ NL E+ + Q++ + + + +++ E ++ F+++Q +
Sbjct: 1485 CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544
Query: 1361 DKLNELRRQKEKLEEK 1376
+K+NEL++ KE + K
Sbjct: 1545 EKVNELKQFKEHRKAK 1560
Score = 144 bits (362), Expect = 1e-33
Identities = 221/1027 (21%), Positives = 434/1027 (42%), Gaps = 140/1027 (13%)
Query: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE 456
E D ++ +E M L+ ++ E+ E +Q+++ E + QK ++
Sbjct: 337 EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN 396
Query: 457 LTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ 516
LT + + Q K + R T KI KM+ N + + I N +
Sbjct: 397 LTRMLVTSSSLTLQQELKAKRKRRVT-----WCLGKINKMKNSNY--ADQFNIPTNITTK 449
Query: 517 -EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENS-ERQIKILEQENEHLNQTVSSLRQRS 574
K S+ + + + + E T++TL E K+L QEN + ++SLR
Sbjct: 450 THKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQEN--IESELNSLRA-- 505
Query: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL 634
+ V D E+ E + K EFE + K + + + L+N +
Sbjct: 506 --DYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLV 563
Query: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK------NLTFQ 688
H E N+ L+ ++++ K+E L ++ ++ +KL++ +DS K +L++
Sbjct: 564 KHAEVYNQDLENELSS------KVELLREKEDQI----KKLQEYIDSQKLENIKMDLSYS 613
Query: 689 LESLEK----ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744
LES+E + + D E + L ES S + +L+ + KEL + +Q++ ++L
Sbjct: 614 LESIEDPKQMKQTLFDAETVALDAKRESAFLRSENL-ELKEKMKELATTYKQMENDIQLY 672
Query: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
++ + ++++V D+E + LQ K ++ ++ + N L+ + +L+
Sbjct: 673 QSQLEAKKKMQV-----DLEKE-LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQ 726
Query: 805 ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK 864
K L + +EN++L +E L + K L E +RLR++ + K EE ++ +
Sbjct: 727 ---KELNKEVEENEALREEVILLS-ELKSLPSEVERLRKEIQDKS---EELHI----ITS 775
Query: 865 ENKTLSKEIGIYKESCVR--LKELEKENKELV------KRATIDIKTLVTLREDLVSEKL 916
E L E+ ++KES V+ L+E+ K +L K + + TL D +K
Sbjct: 776 EKDKLFSEV-VHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDF-EQKY 833
Query: 917 K-----TQQMNNDLEKLTHELEK----IGLNKERLLHDEQSTDDSRYKLLESKLE-STLK 966
K ++MN ++ L+ E +K +G K L + Q + ++ E E LK
Sbjct: 834 KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLK 893
Query: 967 KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1026
+ LE ++ + +E T QQ +E+KT+ + + LKQ Q+ ++ +
Sbjct: 894 EQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH 953
Query: 1027 DN-KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1085
D ++QE R L+ ++++ T+ K + ++ + N
Sbjct: 954 DTVNMNIDTQEQLRNALE------SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007
Query: 1086 LQRQTVSLQEQNT--TLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1143
Q++ V + ++ TQ V+++ + Q + + L+ +++ L+ ESVI
Sbjct: 1008 FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS----LIQEKNELQQMLESVI 1063
Query: 1144 KERE----DLKSLYDSLIKDHEKLELL-------HERQASEYESLISKHGTLKSAHKNLE 1192
E+E DLK + I++ E+L LL E A E I K G L L
Sbjct: 1064 AEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLA 1123
Query: 1193 VEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNH 1252
L+++ QL +++ QL L V++E ++ K
Sbjct: 1124 EVEEKLKEKSQQLQEKQQQL------LNVQEEMSEMQKK--------------------- 1156
Query: 1253 TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCEL 1312
+ E E L+ + KN + L + + E+ L KL E Y+++ + + ++
Sbjct: 1157 -----INEIENLKNELKNKELTLEHMETERLELA---QKLNENYEEVK----SITKERKV 1204
Query: 1313 LSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEK 1372
L +L+ + E E HL I+ + Q E + H+ +++ + ++ELRR +
Sbjct: 1205 LKELQKSFETERDHLRGYIREIEATGL----QTKEELKIAHIHLKEHQETIDELRRSVSE 1260
Query: 1373 LEEKIMD 1379
+I++
Sbjct: 1261 KTAQIIN 1267
Score = 49.7 bits (117), Expect = 3e-05
Identities = 153/761 (20%), Positives = 302/761 (39%), Gaps = 116/761 (15%)
Query: 875 IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMN----NDLEKLTH 930
IY E+ L ++ K L+ R ++ V DL E + T +M EK H
Sbjct: 134 IYNETITDLLCGTQKMKPLIIREDVNRNVYVA---DLTEEVVYTSEMALKWITKGEKSRH 190
Query: 931 ELE-KIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKS-LEI-------KEEKIAALEA 981
E K+ R + +SR K S E ++K S L + + + A
Sbjct: 191 YGETKMNQRSSRSHTIFRMILESREKGEPSNCEGSVKVSHLNLVDLAGSERAAQTGAAGV 250
Query: 982 RLEESTNYNQQLRQELKTVKK----------NYEALKQRQ---------DEERMVQSSPP 1022
RL+E N N+ L + +KK NY K + + R++ + P
Sbjct: 251 RLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITP 310
Query: 1023 ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ 1082
+S ++ + T + +K + EV + A L+ ++ + KQLE + +AQ
Sbjct: 311 VSFDETLTALQFASTAK-YMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQ 369
Query: 1083 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ---------LLIQQS 1133
+ + L+E++ + QN K++ L + S+ + Q + L + +
Sbjct: 370 AMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKIN 429
Query: 1134 SLENEN---------------------------ESVIKEREDLKSLYDSL--IKDHEKLE 1164
++N N ESV E + + D+L I+ + +
Sbjct: 430 KMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATK 489
Query: 1165 LLH-ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED---LEKMLK 1220
LL+ E SE SL + + L ++ L E ++E + LK+K L++ LE+ K
Sbjct: 490 LLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELK----LKEKNDLDEFEALERKTK 545
Query: 1221 VEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1280
+QE L+ ++ ++ ++ N L + S ++ + K L+ +++ KL
Sbjct: 546 KDQEMQLIHEISNLKNLVKHAEV--YNQDLENELSSKVELLREKEDQIKKLQEYIDSQKL 603
Query: 1281 EQTRLEAEFS-----KLKEQYQQL-DITSTKLNNQCELLSQLKGNLE-EENRHLLDQIQT 1333
E +++ +S K+ Q L D + L+ + E NLE +E L
Sbjct: 604 ENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYK 663
Query: 1334 LMLQNRTLLEQNMESKDLFHVE-QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRR 1392
M + L + +E+K V+ +++ NE+ + ++ K+ D
Sbjct: 664 QMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPK-----DLLCNLEL 718
Query: 1393 GNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLED 1452
IT ++L K ++ R++ + L+ +S SE ++ ++ QD S E+
Sbjct: 719 EGKITDLQKELNKEVEENEALREEVILLSELKSLPSE--VERLRKEIQDKS-------EE 769
Query: 1453 GQTLGTKKSSTMNDLVQSMVLAGQWTGSTENL-EVPDDISTGKRRKELGAMAFSTTAINF 1511
+ ++K +++V + G E + + DD++T + + F NF
Sbjct: 770 LHIITSEKDKLFSEVVHK---ESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQ----NF 822
Query: 1512 STVNSSAGFRSKQLVNNKDTTSFE--DISPQGVSDDSSTGS 1550
T++ + K ++ + + E ++S + DSS G+
Sbjct: 823 KTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGA 863
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 204 bits (519), Expect = 6e-52
Identities = 279/1308 (21%), Positives = 573/1308 (43%), Gaps = 187/1308 (14%)
Query: 144 RIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDE 203
++QGLD +++ + ++ + E D+S+E + H I +
Sbjct: 1644 QLQGLDLSSRSLLGIDTEDAIQGRN--------ESCDISKEHTSETTERTPKHDVHQICD 1695
Query: 204 RDEHSETIIELSEERDGLHFLPHASSSA-QSPCGS---PGMKRTESRQHLSVELADAKAK 259
+D + +++ + + P S QSP + PG +T+ EL+ +
Sbjct: 1696 KDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPN 1755
Query: 260 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKA 319
L ++++ +++ +K EN+ LL + ++
Sbjct: 1756 AL--------VPMDFLGNQEDIHNLQLRVKETSNENLRLLH-------------VIEDRD 1794
Query: 320 VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE-DQLEGTRARSDKLH 378
+V+ L +E+ +LH ++ Q++ + + +E +++ G
Sbjct: 1795 RKVESLLNEMKELDSKLH------------LQEVQLMTKIEACIELEKIVG--------- 1833
Query: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEM-AQKQSMDE------SLHLGW 431
EL+KEN L KL + +++E N LEM A K S ++ ++ W
Sbjct: 1834 ELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSW 1893
Query: 432 ELEQISRTSELSE--APQKSLGHEVN------ELTSSRLLKLEMENQSLTKTV----EEL 479
+ + +ELS + + S+ HE E+ + L LE +N++ K + EEL
Sbjct: 1894 KERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEEL 1953
Query: 480 RTTV---DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
+ + G + K +LS+K++ E+ + +C +++ +KEK
Sbjct: 1954 SVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKT 2013
Query: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA------EARVKDIEKENK 590
+L +T+ + + L ++ HL + + SL + SQ + E ++ + KE +
Sbjct: 2014 ELLQTLSS-------DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2066
Query: 591 ILHESIKETSSKLSKIEFEKRQIKKELEH-YKEKGERAEELENELHHLEKENELLQKKIT 649
+L + + ++LS+ ++EK + K LE EKGE A L + ++E L++ I
Sbjct: 2067 LLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSST----QEEVHQLRRGIE 2122
Query: 650 NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL--- 706
L++ +IEA E++ + + ++ ++ DS K+ ++E+LE+E Q+ EEN EL
Sbjct: 2123 KLRV---RIEADEKKQLHIAEKLKERERENDSLKD---KVENLERE-LQMSEENQELVIL 2175
Query: 707 -----RRNVESLKCASMKMAQ----LQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757
+ VE+LK +MA+ +L+ L SEKE L K ++ + + ++L S
Sbjct: 2176 DAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSS 2235
Query: 758 YQGLDIENQRLQKTL-ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ-LEK 815
++ L E ++ + + E S ++ L+++L++L L + E +K + + L+ +E+
Sbjct: 2236 FKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEE 2295
Query: 816 ENK---SLEQETSQLEKDKKQ---LEKENKRLRQQAEIKDTTLE--ENNVKIGNLEKENK 867
E++ S+E+ ++LE D+K+ + ++ K A++ +E E ++I +E+
Sbjct: 2296 EHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHA 2355
Query: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
L E K LK + + ++ +D+ T+ + +E+L +E K Q+ ++LE
Sbjct: 2356 ALEAENS--KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEI 2413
Query: 928 LTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLE------STLKKSLEIKEEKIAALEA 981
+ E I KE+ + + ++L+++L+ + L E + K L +
Sbjct: 2414 INSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSS 2473
Query: 982 RLEESTNYNQQLRQELKTVKKNYEALK-----------------------------QRQD 1012
++E QL Q L K NY L+ Q QD
Sbjct: 2474 QVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQD 2533
Query: 1013 EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQL 1072
+E++V + GE W+ ++ E ++++ ++ ++ NA+LQ + L++ K L
Sbjct: 2534 QEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL 2593
Query: 1073 ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA---QLL 1129
E + + ++ + + + T LQ + ++ + + L + + N+ A QLL
Sbjct: 2594 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653
Query: 1130 IQQ-SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI----SKH-GT 1183
+++ S +++ + + E +LK D + KD + E + +EY+ + KH
Sbjct: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL 2713
Query: 1184 LKSAHKNLEVE----HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAE 1239
L +K EVE L + L QK +++ +LK +E++ K + E
Sbjct: 2714 LLDTNKQYEVEIQTYREKLTSKEECLSSQKLEID----LLKSSKEELNNSLKATTQILEE 2769
Query: 1240 YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKL---KEQY 1296
KK + D L + +QL KE E Q K L + E+ L+ E S+L +E+
Sbjct: 2770 LKKT--KMDNLKYV-NQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826
Query: 1297 QQLDITSTKLNNQCELLSQLKGNLEEENR---HLLDQIQTLMLQNRTL 1341
+ + TK++ + +LK LEE+ + LD+ +L++ + L
Sbjct: 2827 KTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKL 2874
Score = 184 bits (468), Expect = 5e-46
Identities = 253/1084 (23%), Positives = 480/1084 (44%), Gaps = 153/1084 (14%)
Query: 206 EHSETIIELSEERDGLH--FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRL 263
+H E +++ E +GL+ HA S++ G K +S + D + ++ R+
Sbjct: 1852 DHQE-LLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE---RFLDVENELSRI 1907
Query: 264 RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL----------LSDARSAR-MYRDEL 312
R E + L + +LE ++ E L+++N N LS S R R EL
Sbjct: 1908 RSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL 1967
Query: 313 DALREKAVRVDKLESEV--------SRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
D + +K +D+L ++ S E LH I+ +A E+KE ++L + +
Sbjct: 1968 DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA---EVKEKTELLQTLSSDVS 2024
Query: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
+ L+ +KL LEK++ L ++E + K+ E L++E+ +L+ +S
Sbjct: 2025 ELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDY 2084
Query: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
E L++ LE + L E + +L RL + E L + +E+LR ++
Sbjct: 2085 EKLNVSKALE-----AALVEKGEFAL----------RLSSTQEEVHQLRRGIEKLRVRIE 2129
Query: 485 SVEGN----ASKILKMEKENQRLSKKVEILENEIVQEKQSLQ----NCQNLSKDLMKEKA 536
+ E A K+ + E+EN L KVE LE E+ +++ + + +N ++ K
Sbjct: 2130 ADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKT 2189
Query: 537 QLEK-------------TIETLRENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEAR 581
Q+E+ T+ + +EN +QI+ + + L++ +SS + + AE +
Sbjct: 2190 QIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQ 2249
Query: 582 VKD--------IEKENKILHESI----------KETSSKLSKIEFEKRQIKKELEHYKEK 623
+K+ ++ + K L+E++ K T L E+ Q++ +E + +
Sbjct: 2250 IKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRAR 2309
Query: 624 GERAEELE----NELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK-KT 678
E E+ + +L E +LL+ ++ NL+ E I QE++ LE EN K + +T
Sbjct: 2310 LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELE-IARTNQEHAALEAENSKGEVET 2368
Query: 679 LDS-FKNLTFQLESLEKE--NSQLDEENLELRRNVESLKCASMKMAQLQLEN--KELESE 733
L + + +T L LE + + ++ENL E + + +++ EN +E E E
Sbjct: 2369 LKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQE 2428
Query: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
K Q+K+ S E L+ + L+ L E K Q L S+++ LE+E
Sbjct: 2429 KVQMKE------KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2482
Query: 794 QTLQKNLEELKIS--------SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
L + L+E K + + ++++E + LE++ ++ + K Q++ + + + + +
Sbjct: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS 2542
Query: 846 EI-------KDTTLEENNV------KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKE 892
++ K+ LE N+ KI L+ +N +L + + + S L E E E +
Sbjct: 2543 QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL-ENELELTK 2601
Query: 893 LVKRATIDIKTLVTLRE-DLVSEKLKTQQMNNDL-EKLTHELEKIGLNKERLLHDEQSTD 950
+ K + ++ +T +E +L E + Q +L E+L+ E ++ + LL + +S+
Sbjct: 2602 MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK 2661
Query: 951 DSRYKLLESKLE-STLKKSLEIKE-----------EKIAALEARLEESTNYNQQLRQELK 998
D +L E LE S LKKSL+ E+IA + RL E+ +Q L L
Sbjct: 2662 D---QLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL---LL 2715
Query: 999 TVKKNYEALKQRQDEERMVQSSPPISGEDNKWE--RESQETTRELLKVKDRLIEVERNNA 1056
K YE Q E++ +S + + + + S+E LK +++E
Sbjct: 2716 DTNKQYEVEIQTY-REKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE------ 2768
Query: 1057 TLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS 1116
L+ K + QL+ +N Q ++ L + L+E+ LQ + ++LQ +
Sbjct: 2769 ELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKT 2828
Query: 1117 QSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYES 1176
T + + +L + L+ E KE ++ Y SL+ HEKLE E ++
Sbjct: 2829 -GTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAH 2887
Query: 1177 LISK 1180
L S+
Sbjct: 2888 LCSQ 2891
Score = 161 bits (407), Expect = 6e-39
Identities = 319/1517 (21%), Positives = 624/1517 (41%), Gaps = 248/1517 (16%)
Query: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Q L +L K + ++ + +L+ L KQ++E + E L++EN L+ S
Sbjct: 21 QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLE 80
Query: 307 MYRDELD---ALREKAV------------RVDKLESEVSRYKERLH---------DI--- 339
+ ++ ++E V +++KLE E+ R K L D+
Sbjct: 81 KTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLN 140
Query: 340 ----------------EFYK-ARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEK 382
++Y ++ E+LKE +E + LE +++ +A+ +
Sbjct: 141 PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAK-------KA 193
Query: 383 ENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD------ESLHLGWELEQI 436
+A ++ ++ R + +E ++ + + E E
Sbjct: 194 SQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVT 253
Query: 437 SRTSELSEAPQKSLGHEVNELTSSRLL-KLEMENQSLTKTVEELRTTVD----SVEGNAS 491
S L + + + +S LL +L+ +NQ L + EL + ++G +
Sbjct: 254 PSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVN 313
Query: 492 KI----LKMEKENQRLSKKVEIL---ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
K L++EK L +K ++L +E+V+ L ++ +L + +
Sbjct: 314 KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373
Query: 545 LRENSERQIKILEQ---ENEHLNQTVSSLRQRS-------QISAEARVKDIEKENKILHE 594
R+N+E LEQ E E Q S +QRS I +AR+ ++ K +H
Sbjct: 374 QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
Query: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE-----------ELENELHHLEKENEL 643
++ KL+ + K+Q++ LE +K+K RAE EL + ++KEN L
Sbjct: 434 VLQAELDKLTSV---KQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL 490
Query: 644 LQ-------KKITNLKITCEKI-EALEQENS---ELERENRKLKKTL-DSFKNLTFQLES 691
L+ +++ +L+ + I + L Q + E++ +N + L D + + Q S
Sbjct: 491 LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS 550
Query: 692 LEKENSQLDEENLELRRNV--ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
L E +L +LE +R+ + LK + QL + + E E + L LEL K ++
Sbjct: 551 LTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYE 610
Query: 750 KTERLEVSYQGLDIENQRL----QKTLENSNKKIQQLESELQDLEMEN-------QTLQK 798
+ + + + EN++L + EN KI LE+ L+ ++++ +TL+
Sbjct: 611 ELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEM 670
Query: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV- 857
+ E L + + L + ++KS+E ET +L + Q + E + Q EI++ L+ + +
Sbjct: 671 DRENLSVEIRNLHNV-LDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLT 729
Query: 858 -KIGNLEKENKTLSKEIGIYKESCVRLKELEKEN-KELVKRATIDIKTLVTLREDLVSEK 915
++ +LE + + LS EI + K+ C + E E+ ++L+K + T + L++
Sbjct: 730 GQVEDLEHKLQLLSNEI-MDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFD 788
Query: 916 LKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDS-----RYKLLESKLESTLKKSLE 970
+ ++ + + E L +QS +S R LE LES + + +
Sbjct: 789 QQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSD 848
Query: 971 IKE--EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS--SPPISGE 1026
+++ E++ ++ +EE+ +Q+ Q V + + + + Q++ Q+ + +S
Sbjct: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSF--VAETSQRISKLQEDTSAHQNVVAETLSAL 906
Query: 1027 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1086
+NK E+E Q ++ + + E++++N L+ + L+ + L + + + I
Sbjct: 907 ENK-EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN 965
Query: 1087 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN---QNAQLLIQQSSLENENESVI 1143
+R+ L ++N TL+ NA L E L +S S N + + + + S + + ++
Sbjct: 966 KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL 1025
Query: 1144 KER--------EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSA----HKNL 1191
+R EDL Y + + + KLE L S E+ ++ LK A H+
Sbjct: 1026 LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085
Query: 1192 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA-----EYKKLCGE 1246
+ E+R L+ +LE +++ L+ E + +N+N+ A E L E
Sbjct: 1086 LTKLAFAEERNQNLML---ELETVQQALRSE----MTDNQNNSKSEAGGLKQEIMTLKEE 1138
Query: 1247 NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL 1306
+++ + LL+E E L +K + + + E + +KE+ +
Sbjct: 1139 QNKMQKEVNDLLQENEQL------MKVMKTKHECQNLESEPIRNSVKERESE-------- 1184
Query: 1307 NNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1366
NQC Q+ ++E + LD ++Q LE + +K+L KL E
Sbjct: 1185 RNQCNFKPQMDLEVKEIS---LDSYNAQLVQ----LEAMLRNKEL----------KLQES 1227
Query: 1367 RRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSD 1426
++KE L+ ++ RG+ T ++ + + Q+ L D
Sbjct: 1228 EKEKECLQHELQ-----------TIRGDLETSNLQDM---------QSQEISGLKDCEID 1267
Query: 1427 SSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMNDL-----VQSMVLAGQWTGST 1481
+ E ++ PH+ S S D L +TMN L + ++ A ++ T
Sbjct: 1268 AEEKYISGPHE--------LSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVT 1319
Query: 1482 ENLEVPDDISTGKRR--KELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISP 1539
E + + T R+ +E+G + +N +G +LV EDI P
Sbjct: 1320 ELNDSRSECITATRKMAEEVGKLLNEV-----KILNDDSGLLHGELV--------EDI-P 1365
Query: 1540 QGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFS 1599
G G + + P SL S S + S EV+ Q + S S E
Sbjct: 1366 GG-----EFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQS-EHK 1419
Query: 1600 LLHDHEAWSSSGSSPIQ 1616
+LHD SS S +Q
Sbjct: 1420 ILHDQHCQMSSKMSELQ 1436
Score = 155 bits (392), Expect = 3e-37
Identities = 267/1235 (21%), Positives = 517/1235 (41%), Gaps = 174/1235 (14%)
Query: 279 QELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHD 338
Q+++++E +L +L++E +++ ++D LE+ + + K++
Sbjct: 18 QKIQELEGQLDKLKKEK--------------------QQRQFQLDSLEAALQKQKQK--- 54
Query: 339 IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398
+E K LK +NQ L+E + + LE T+ + HEL+ + Q+ + + +
Sbjct: 55 VENEKTEGTNLKRENQRLME----ICESLEKTKQKIS--HELQVKESQVNFQEGQLNSGK 108
Query: 399 DMDRKKIEELMEENMTLEMAQK--QSMDESLHLGWELEQISRT-----SELSEAPQKSLG 451
K +EL LE +Q+ QS D SL+ ++I T S + + L
Sbjct: 109 KQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLK 168
Query: 452 HEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
+ N+ R +LE E ++L ++ T+ N I + + + S + E
Sbjct: 169 EKYNKEVEER-KRLEAEVKAL--QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTP 225
Query: 512 NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLR-------------ENSERQIKILEQ 558
+ + Q ++ S + ++ + TL+ +S + L+
Sbjct: 226 SHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKA 285
Query: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
+N+ L ++ L E R++ EKE K +E +L K + E + +K L
Sbjct: 286 QNQELRNKINEL--------ELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLN 337
Query: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA------LEQENSELERE- 671
+++ R ++ E KK+T ++C++ A LEQ+ E E+E
Sbjct: 338 KCRDELVRTTAQYDQASTKYTALEQKLKKLTE-DLSCQRQNAESARCSLEQKIKEKEKEF 396
Query: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
+L + SF+ L + ++ +Q + + + NV + + + QLEN LE
Sbjct: 397 QEELSRQQRSFQTLDQECIQMKARLTQ-ELQQAKNMHNVLQAELDKLTSVKQQLEN-NLE 454
Query: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
K++L + + +AS K L S + + EN L+ E +++ LE+EL++++
Sbjct: 455 EFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQ 514
Query: 792 ENQTLQKNLEELKISSKRLEQL--EKENKSLEQETS-QLEKDK---KQLEKENKRLRQQA 845
Q EE+K + E + + + K +QE S LEK K LEK+ +
Sbjct: 515 CLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLL 574
Query: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
+ ++ +E+ N K+ EKE+K L + + K+ L KE K L + + L+
Sbjct: 575 KKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEEL----KEEKTLFSCWKSENEKLL 630
Query: 906 TLREDLVSEKLKTQQMNNDLEKL--THELEKIGLNKE-RLLHDEQSTDDSRYKLLESKLE 962
T E SEK Q N LE T +++ N+ R L ++ + L + L+
Sbjct: 631 TQME---SEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLD 687
Query: 963 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1022
S KS+E++ +K+A +E L++ ++ Q K +++ E M +
Sbjct: 688 S---KSVEVETQKLAYME--LQQKAEFSDQ---------------KHQKEIENMCLKTSQ 727
Query: 1023 ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ---NNNL 1079
++G+ E + Q + E++ KDR + L AE ++L+ LK + N +
Sbjct: 728 LTGQVEDLEHKLQLLSNEIMD-KDRCYQ------DLHAEYESLRDLLKSKDASLVTNEDH 780
Query: 1080 QAQILALQRQT------VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS 1133
Q +LA +Q ++ + ++ ++ ++ ++E S L N+ L
Sbjct: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE 840
Query: 1134 SLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN--- 1190
S + N + K+ E+L + + ++ K E +H+ +E ISK SAH+N
Sbjct: 841 SQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVA 900
Query: 1191 -----LEVEHRDL----------EDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHET 1235
LE + ++L + +L K LED K L++ E + LE K +
Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960
Query: 1236 VAA----EYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1291
+ + E ++L EN L + L +E L ++ + ++ E S+
Sbjct: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDER-------EKSISE 1013
Query: 1292 LKEQYQQLDI----TSTKLNNQCELLSQLKGNLEEENRH---LLDQIQTLMLQNRTLLEQ 1344
L +QY+Q + + N E LSQ +E+N LL++ +L + LEQ
Sbjct: 1014 LSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQ 1073
Query: 1345 NMESKDLFHVEQRQYIDKLN-----------ELRRQKEKLEEKIMDQYKFYDPSPPRRRG 1393
K+ F E ++++ KL EL ++ L ++ D +
Sbjct: 1074 ---LKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQ 1130
Query: 1394 NWITLK--MRKLIKSKKDINRERQKSLTLTPTRSD 1426
+TLK K+ K D+ +E ++ + + T+ +
Sbjct: 1131 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHE 1165
Score = 153 bits (387), Expect = 1e-36
Identities = 239/1191 (20%), Positives = 510/1191 (42%), Gaps = 153/1191 (12%)
Query: 251 VELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
VEL + + + + R EL T Q + +E +LK+L ++ +A SAR +
Sbjct: 327 VELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLE 386
Query: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEF----YKARV----EELKEDNQVL---LET 359
+ +EK + + E+SR + ++ KAR+ ++ K + VL L+
Sbjct: 387 QKIKEKEK-----EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDK 441
Query: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
T ++ QLE + L E +++ + + +++ + R+ +EE+ +EN L+
Sbjct: 442 LTSVKQQLE------NNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHS 495
Query: 420 KQSMDESLHLGWELEQISRTSELSEA-PQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
+Q E HL EL+ I + S+ ++ ++ T R L+ ++ Q + T+E+
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555
Query: 479 LRTTVDSVEGNAS------------------KILKMEKENQRLSKKVEILENEI--VQEK 518
L+ V +E K+ K EKE++ L +E+ + E ++E+
Sbjct: 556 LKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE 615
Query: 519 QSLQNCQNLSKDLMKEKAQLEK-TIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQI 576
++L +C + + + + EK +++ + E +K + ++ N+ V +L R +
Sbjct: 616 KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENL 675
Query: 577 SAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE---RAEELENE 633
S E R N + +S++ + KL+ +E +++ + +H KE + +L +
Sbjct: 676 SVEIR----NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ 731
Query: 634 LHHLEKENELLQKKITNLKITCEKIEA--------LEQENSELERENRKLKKTL------ 679
+ LE + +LL +I + + + A L+ +++ L + L
Sbjct: 732 VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQP 791
Query: 680 ---DSFKNLTFQLESLEKENS-------QLDEENLELRRNVESLKCASMKMAQLQLENKE 729
SF N+ + S+ E S Q + + L+ V+SL+ + Q+ N +
Sbjct: 792 AMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQM---NSD 848
Query: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
L+ + E+L + ++ + K E++ S+ + +QR+ K E+++ + L L
Sbjct: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSF--VAETSQRISKLQEDTSAHQNVVAETLSAL 906
Query: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
E + + LQ ++++ +++L+K N LE +L+ + L E K + +
Sbjct: 907 ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966
Query: 850 TTLEENNVKIGNLEKENKTLSKE-IGIYKES---CVRLKELEKENKELVKRATIDIKTLV 905
+EE + G L++ N +L++E + + ++S + E EK EL + + L+
Sbjct: 967 REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
Query: 906 -------TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLE 958
EDL + Q+ N+ LE L +E + N++ L + ++
Sbjct: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFL 1086
Query: 959 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1018
+KL +++ + E +A E T+ + E +K+ LK+
Sbjct: 1087 TKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKE--------- 1137
Query: 1019 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ-AEKQALKTQLKQLETQNN 1077
E NK ++E +LL+ ++L++V + Q E + ++ +K+ E++ N
Sbjct: 1138 -------EQNKMQKE----VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERN 1186
Query: 1078 NLQAQILALQRQTVSLQEQNTTLQTQNAKL-QVENSTLNSQSTSLMNQNAQLLIQQSSLE 1136
+ + L+ + +L + NA+L Q+E M +N +L +Q+S E
Sbjct: 1187 QCNF------KPQMDLEVKEISLDSYNAQLVQLE----------AMLRNKELKLQES--E 1228
Query: 1137 NENESVIKEREDLK-SLYDSLIKDHEKLEL--LHERQASEYESLISKHGTLKSAHKNLEV 1193
E E + E + ++ L S ++D + E+ L + + E IS L ++ +
Sbjct: 1229 KEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAH 1288
Query: 1194 EHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE-NKNHETVAAEYKKLCGENDRLNH 1252
L+ N+L +LE + ++L+ E+ +++ E N + +K+ E
Sbjct: 1289 LQCSLQTTMNKL----NELEKICEILQAEKYELVTELNDSRSECITATRKMAEE------ 1338
Query: 1253 TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCEL 1312
+LL E ++L D S L + +L + EF + + + + +N E
Sbjct: 1339 -VGKLLNEVKILNDD-----SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEH 1392
Query: 1313 LSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1363
L+ ++ L ++ +L +++ L +Q+ + E + Y+D L
Sbjct: 1393 LTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMS-ELQTYVDSL 1442
Score = 141 bits (355), Expect = 7e-33
Identities = 287/1289 (22%), Positives = 518/1289 (40%), Gaps = 238/1289 (18%)
Query: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ----ENMNLL 299
+ + L+ EL AK L+ EL++ T + LE+ + +L R +Q +
Sbjct: 416 QMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKEN 475
Query: 300 SDARSARMYRDELDALR----EKAVRVDKLESEVSRYKERLHDIEFYKARVEELK----- 350
RS + E + L+ +KA V LE+E+ K+ L+ + + EE+K
Sbjct: 476 ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNF---AEEMKAKNTS 532
Query: 351 --------------EDNQVLLETKTMLEDQLEGTR-ARSDKLHELEKENLQLKAKLHDME 395
++N + LE + LE R D L + E QL KL E
Sbjct: 533 QETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTE 592
Query: 396 MER-------DMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE---- 444
E ++ +K+ EEL EE TL K S +E L E E+ + S+++
Sbjct: 593 KESKALLSALELKKKEYEELKEEK-TLFSCWK-SENEKLLTQMESEKENLQSKINHLETC 650
Query: 445 -APQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD--SVEGNASKILKMEKEN- 500
Q+ HE NE R+ LEM+ ++L+ + L +D SVE K+ ME +
Sbjct: 651 LKTQQIKSHEYNE----RVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706
Query: 501 --------------------------QRLSKKVEILENEIVQEKQSLQNCQ---NLSKDL 531
+ L K+++L NEI+ + + Q+ +DL
Sbjct: 707 AEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDL 766
Query: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE----- 586
+K K + ++ T E+ +R + +Q+ + + + ++ + +E +E
Sbjct: 767 LKSK---DASLVT-NEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSP 822
Query: 587 KENKILH----------ESIKETSSKLSKIEFEKRQIKKELEHYKEKGER-----AEELE 631
K + IL ES K+ +S L K E QIK E+E K E+ E
Sbjct: 823 KNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS 882
Query: 632 NELHHLEKEN-----------ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD 680
+ L+++ L+ K L++ +K+E + E EL++ N L+ +L
Sbjct: 883 QRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK 942
Query: 681 SFKNL--TFQLESLE---------KENSQLDEENLELRRNVESLKCASMKMAQ------- 722
+ L T LE E +E +L +EN L+ SL M + Q
Sbjct: 943 ELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFAN 1002
Query: 723 -LQLENKELESEKEQLKKGLELLKASFKKT----ERLEVSYQGLDIENQRLQKTL----- 772
+ K + +Q K+ +L ++T E L Y+ +N +L+ L
Sbjct: 1003 YIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS 1062
Query: 773 --ENSNKKIQQLE-----------SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
EN +++QL+ ++L E NQ L LE ++ + R E + +N S
Sbjct: 1063 LCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQ-QALRSEMTDNQNNS 1121
Query: 820 -------------LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866
L++E ++++K+ L +EN++L + + K + I N KE
Sbjct: 1122 KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKER 1181
Query: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
++ + + + +KE+ ++ LV L L +++LK Q+ + E
Sbjct: 1182 ESERNQCNFKPQMDLEVKEISLDSYN---------AQLVQLEAMLRNKELKLQESEKEKE 1232
Query: 927 KLTHELEKI-GLNKERLLHDEQSTDDSRYKLLESKLESTL---KKSLEIKEEKIAALEAR 982
L HEL+ I G + L D QS + S K E E L + A L+
Sbjct: 1233 CLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCS 1292
Query: 983 LEESTNYNQQLRQELKTVK-KNYEALKQRQD-EERMVQSSPPISGEDNKWERESQETTRE 1040
L+ + N +L + + ++ + YE + + D + ++ ++ E K E + +
Sbjct: 1293 LQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDD 1352
Query: 1041 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN---------NLQAQILALQRQTV 1091
+ L+E + + L L+ N+ +Q LQ + +
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFL 1412
Query: 1092 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE---- 1147
SLQ ++ L Q+ ++ + S L + SL +N L+ ++L N ++KE +
Sbjct: 1413 SLQSEHKILHDQHCQMSSKMSELQTYVDSLKAEN---LVLSTNLRNFQGDLVKEMQLGLE 1469
Query: 1148 --DLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL 1205
+ SL S + D L L + +S Y +L+ + G + S NLE + +++
Sbjct: 1470 EGLVPSLSSSCVPDSSSLSSLGD--SSFYRALLEQTGDM-SLLSNLEGAVSANQCSVDEV 1526
Query: 1206 LKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE--- 1262
Q E+L + ET +A K + E + L Y Q L++ E
Sbjct: 1527 FCSSLQEENLTR---------------KETPSAPAKGV-EELESLCEVYRQSLEKLEEKM 1570
Query: 1263 -----VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLK 1317
+ + + L+ LL++ + E L ++ EQ+QQ +TS L + +L ++ K
Sbjct: 1571 ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ-KLTSVTLEMESKLAAEKK 1629
Query: 1318 G----NLEEENRHLLDQIQTLMLQNRTLL 1342
+LE E L Q+Q L L +R+LL
Sbjct: 1630 QTEQLSLELEVARL--QLQGLDLSSRSLL 1656
Score = 139 bits (349), Expect = 3e-32
Identities = 204/953 (21%), Positives = 411/953 (43%), Gaps = 126/953 (13%)
Query: 502 RLSKKVEILENEIVQEKQSLQNCQ----NLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
R +K++ LE ++ + K+ Q Q +L L K+K ++E N + + L+
Sbjct: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVE--------NEKTEGTNLK 66
Query: 558 QENEHLNQTVSSLRQRSQ-ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616
+EN+ L + SL + Q IS E +VK E + + ++ K+E E ++ K E
Sbjct: 67 RENQRLMEICESLEKTKQKISHELQVK--ESQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
Query: 617 LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
LE ++ + A+ N + +KI +T + + S+ E K
Sbjct: 125 LERSQQAAQSADVSLNPCN--------TPQKIFTTPLTPSQYYS----GSKYEDLKEKYN 172
Query: 677 KTLDSFKNLTFQLESLE--KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
K ++ K L ++++L+ K + L + + R +S+ Q + L S
Sbjct: 173 KEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNS 232
Query: 735 EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQ 794
++ + + F + + S L I + + +++ L+ L+ +NQ
Sbjct: 233 QRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQ----LKAQNQ 288
Query: 795 TLQKNLEELKISSKRLEQLEKENKS----LEQETSQLEKDKKQL-EKENKRLRQQAEIKD 849
L+ + EL++ RL+ EKE K ++ QLEK K +L EKE + + E+
Sbjct: 289 ELRNKINELEL---RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVR 345
Query: 850 TTLE--ENNVKIGNLEKENKTLSKEIGIYKESCV--------RLKELEKENKELVKRATI 899
TT + + + K LE++ K L++++ +++ ++KE EKE +E + R
Sbjct: 346 TTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR 405
Query: 900 DIKTL----VTLREDLVSEKLKTQQMNN----DLEKLTHELEKIGLN----KERLLHDEQ 947
+TL + ++ L E + + M+N +L+KLT +++ N K++L EQ
Sbjct: 406 SFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQ 465
Query: 948 STDDSRYK-------LLESKLESTLKKS-LEIKEEKIAALEARLE---ESTNYNQQLRQE 996
+ S+ K + E K E+ L KS E K ++ LEA L+ + N +Q +E
Sbjct: 466 AFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEE 525
Query: 997 LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE----RESQETTRELLK--------V 1044
+K + E + R +E++ Q ++ E K + ++ +++LLK +
Sbjct: 526 MKAKNTSQETML-RDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQL 584
Query: 1045 KDRLIEVERNNATLQAEKQALKTQLKQLE----------TQNNNLQAQILALQRQTVSLQ 1094
D+L + E+ + L + + K + ++L+ ++N L Q ++ + +LQ
Sbjct: 585 NDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQ---MESEKENLQ 641
Query: 1095 EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD 1154
+ L+T Q+++ N + +L L ++ +L N +S E E K Y
Sbjct: 642 SKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYM 701
Query: 1155 SLIKDHEKLELLHERQASEYESLISKH----GTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1210
L +K E ++ E E++ K G ++ L++ ++ D+
Sbjct: 702 EL---QQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHA 758
Query: 1211 QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN 1270
+ E L +LK ++ L+ N++H+ + + ++H+++ ++ E + ++
Sbjct: 759 EYESLRDLLK-SKDASLVTNEDHQRSLLAFD----QQPAMHHSFANIIGEQGSMPSERSE 813
Query: 1271 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE-----ENR 1325
+ + S L+ L+ + ++ L QCE L Q+KG +EE E
Sbjct: 814 CRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873
Query: 1326 HLLDQIQTLM----LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLE 1374
H +T LQ T QN+ ++ L +E ++ EL+ +K+E
Sbjct: 874 HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE-----KELQLLNDKVE 921
Score = 122 bits (306), Expect = 3e-27
Identities = 370/1812 (20%), Positives = 718/1812 (39%), Gaps = 334/1812 (18%)
Query: 136 QKKEEFIERIQG-LDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMA 194
QK+ E + +I+G ++ + A H V + + LQ E T Q + L +
Sbjct: 850 QKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQ--EDTSAHQNVVAETLSALE 907
Query: 195 LHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
K L D+ E+ E + H L + Q + LS+E
Sbjct: 908 NKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQL-----------LSETLSLEKK 956
Query: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
+ + I ++E+EE T++ K EI L QE MNL+ + S Y DE
Sbjct: 957 EMSSIISLNKREIEELTQENGTLK------EINAS-LNQEKMNLIQKSESFANYIDE--- 1006
Query: 315 LREKAVRVDKLESEVS-RYKER----LHDIEFYKARVEELKEDNQVLLETKTMLEDQL-E 368
REK++ SE+S +YK+ L E E+L + + E + LE L E
Sbjct: 1007 -REKSI------SELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNE 1059
Query: 369 GTRARSDKLHELE-------KENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
T ++ +ELE KE+ + KL E ER+ + E +++ + EM Q
Sbjct: 1060 CTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAE-ERNQNLMLELETVQQALRSEMTDNQ 1118
Query: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS-----RLLKLEMENQSLTKTV 476
+ +S G + E ++ E Q + EVN+L +++K + E Q+L
Sbjct: 1119 NNSKSEAGGLKQEIMTLKEE-----QNKMQKEVNDLLQENEQLMKVMKTKHECQNLES-- 1171
Query: 477 EELRTTVDSVEGNASKIL---KMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMK 533
E +R +V E ++ +M+ E + +S ++ ++VQ + L+N + ++ K
Sbjct: 1172 EPIRNSVKERESERNQCNFKPQMDLEVKEIS--LDSYNAQLVQLEAMLRNKELKLQESEK 1229
Query: 534 EKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR------QRSQISAEARVKDIEK 587
EK L+ ++T+R + E + +Q +S L+ + IS + +
Sbjct: 1230 EKECLQHELQTIRGDLETS-----NLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQN 1284
Query: 588 ENKILHESIKETSSKLSKIE-------FEKRQIKKELEHYKEK--------GERAEELEN 632
+N L S++ T +KL+++E EK ++ EL + + E +L N
Sbjct: 1285 DNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLN 1344
Query: 633 ELHHLEKENELLQKKITNLKITCE-----------KIEALEQENS--ELERENRKLK--- 676
E+ L ++ LL ++ E + L++ NS L +++++
Sbjct: 1345 EVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHF 1404
Query: 677 -KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKE 735
+ + F +L + + L ++ Q+ + EL+ V+SLK ++ ++ L N + + KE
Sbjct: 1405 AELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLST-NLRNFQGDLVKE 1463
Query: 736 Q---LKKGL---------------------ELLKASFKKTERL----------------- 754
L++GL +A ++T +
Sbjct: 1464 MQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSV 1523
Query: 755 -EVSYQGLDIEN--------------QRLQKTLENSNKKIQQLESELQDLE-MENQTLQK 798
EV L EN + L+ E + +++LE +++ M+N+ +Q+
Sbjct: 1524 DEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQE 1583
Query: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
+ L + L+ L K+ S E E Q + LE E+K ++ + + +LE ++
Sbjct: 1584 LEQLLSSERQELDCLRKQYLS-ENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLE---LE 1639
Query: 859 IGNLEKENKTLSKE--IGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL--VSE 914
+ L+ + LS +GI E ++ + E+ ++ K T + T T + D+ + +
Sbjct: 1640 VARLQLQGLDLSSRSLLGIDTEDAIQGR---NESCDISKEHTSE-TTERTPKHDVHQICD 1695
Query: 915 KLKTQQMNNDLEKLTH------------------------------------ELEKIG-- 936
K Q +N D+EK+T EL G
Sbjct: 1696 KDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPN 1755
Query: 937 -------LNKERLLHDEQ----STDDSRYKLL------ESKLESTLKKSLEI-------- 971
L + +H+ Q T + +LL + K+ES L + E+
Sbjct: 1756 ALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQE 1815
Query: 972 -----KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS-----SP 1021
K E LE + E N L ++L+ +++ L QR + + S +
Sbjct: 1816 VQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHAD 1875
Query: 1022 PISGED---------NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQL 1072
S ED + W+ + EL +++ +E L+A+ + ++T+ L
Sbjct: 1876 KSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCL 1935
Query: 1073 ETQNNNLQAQILALQRQ-TVSLQEQN-------------TTLQTQNAKLQVENSTLNSQS 1118
E N N Q I+ L+ + +V E+N T L + K++ + L S
Sbjct: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995
Query: 1119 TSLMN--QNAQLLIQQ-----SSLENENESVIKEREDLKSLYDSLIKDHEKLELLH---E 1168
+ ++ Q A+ +++ +L ++ ++K++ L+ SL KD + L L E
Sbjct: 1996 SECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELE 2055
Query: 1169 RQAS----EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL--------EDLE 1216
Q + E E L+ + +L++ + E ++ L +KG+ E++
Sbjct: 2056 NQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVH 2115
Query: 1217 KMLK-VEQEKMLLE--NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKS 1273
++ + +E+ ++ +E K +A + K+ END L L +E ++ + + + +
Sbjct: 2116 QLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVIL 2175
Query: 1274 LLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQT 1333
NSK E L+ + ++ + ++ L ++ E L++ +E + L ++
Sbjct: 2176 DAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTK----QIQEKQGQLSELDK 2231
Query: 1334 LMLQNRTLLEQNMESKDLFHVEQRQYIDKL-NELRRQKEKLEEKIMDQ--YKFYDPS--P 1388
L+ ++LLE+ +++ E + ++ L N+L+ E + DQ K + S P
Sbjct: 2232 LLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDP 2291
Query: 1389 P-----RRRGNWITLKMRKLIKSKKDI-----NRERQKSLTLTPTRSDSSEGFLQLPHQD 1438
P + R + L+ R KK + +E + L R ++ E L++ +
Sbjct: 2292 PIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTN 2351
Query: 1439 SQDSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKE 1498
+ ++ NS + +TL K L + ENL T + +KE
Sbjct: 2352 QEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENL-------TNELQKE 2404
Query: 1499 LGAMAFSTTAINFSTVN-SSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRP 1557
++ IN S N + K + K +T+ E + Q + + + + +H +
Sbjct: 2405 QERIS-ELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ-LKELNERVAALHNDQE 2462
Query: 1558 ASLDSGRTSTSNSN----NNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSS 1613
A + +S A L + A NN QS +G + D +
Sbjct: 2463 ACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDE 2522
Query: 1614 PIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSS 1673
I LK Q + L K+S+ +E H K E+ L LE+ K+ +Q K++
Sbjct: 2523 EISRLKNQIQDQEQLVSKLSQ-VEGEHQLWK--EQNLELRNLTVELEQ--KIQVLQSKNA 2577
Query: 1674 SQENLLDEVMKS 1685
S ++ L+ + S
Sbjct: 2578 SLQDTLEVLQSS 2589
Score = 97.1 bits (240), Expect = 1e-19
Identities = 186/857 (21%), Positives = 339/857 (39%), Gaps = 138/857 (16%)
Query: 716 ASMKMAQLQLENKELESEKEQLKKGLELLKASFKK----TERLEVSYQGLDIENQRLQKT 771
A K+ +L+ + +L+ EK+Q + L+ L+A+ +K E + L ENQRL +
Sbjct: 16 ALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEI 75
Query: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKISS--KRLEQLEKENKSLEQETSQLEK 829
E+ K Q++ ELQ E Q N +E +++S K++E+LE+E K + E + ++
Sbjct: 76 CESLEKTKQKISHELQVKES-----QVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ 130
Query: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE 889
+ + +I T L + G+ ++ K Y + K LE E
Sbjct: 131 AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEK------YNKEVEERKRLEAE 184
Query: 890 NKEL-VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK----LTHELEKIGLNKE---R 941
K L K+A+ + D+ + + + EK L+ ++ + ++
Sbjct: 185 VKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSAS 244
Query: 942 LLHDEQSTDDSRYKLLESKLEST---------------LKKSLEIKEEKIAALEARLE-- 984
EQ SR L K ++ LK + KI LE RL+
Sbjct: 245 YFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGH 304
Query: 985 -----ESTNYNQQLRQELKTVK----KNYEALKQRQDE-----ERMVQSSPPISG----- 1025
N Q+L+ +L+ K + + L + +DE + Q+S +
Sbjct: 305 EKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364
Query: 1026 ----EDNKWERESQETTRELLKVK---------DRLIEVERNNATLQAE----KQALKTQ 1068
ED +R++ E+ R L+ K + L +R+ TL E K L +
Sbjct: 365 KKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQE 424
Query: 1069 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128
L+Q + +N LQA++ L +V Q +N + + + E + SQ
Sbjct: 425 LQQAKNMHNVLQAELDKL--TSVKQQLENNLEEFKQKLCRAEQAFQASQ----------- 471
Query: 1129 LIQQSSLENENESVIKEREDLKSLYDSLIKD--HEKLELLHERQASEYESLISKHGTLKS 1186
I+++ L E + KE LKS + ++ H + EL + +Q ++ +K+
Sbjct: 472 -IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEE--MKA 528
Query: 1187 AHKNLEVEHRDLEDRYNQ------LLKQKGQLEDLEKMLKVEQEKMLLENKNH------- 1233
+ + E RDL+++ NQ L K K + DLEK Q+ LL+ + H
Sbjct: 529 KNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQD--LLKKREHHIEQLND 586
Query: 1234 --ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1291
E K L + Y +L +E + + LL + E+ L+++ +
Sbjct: 587 KLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINH 646
Query: 1292 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL------LEQN 1345
L+ + I S + N + L + NL E R+L + + + ++ T L+Q
Sbjct: 647 LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706
Query: 1346 MESKDLFH--------VEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWIT 1397
E D H ++ Q ++ +L + + L +IMD+ + Y
Sbjct: 707 AEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYE----- 761
Query: 1398 LKMRKLIKSKKD---INRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQ 1454
+R L+KSK N + Q+SL + F + + S LE Q
Sbjct: 762 -SLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
Query: 1455 TLGTKKSSTMNDLVQSM 1471
+ K S+ + + V S+
Sbjct: 821 S--PKNSAILQNRVDSL 835
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 202 bits (515), Expect = 2e-51
Identities = 248/1149 (21%), Positives = 495/1149 (43%), Gaps = 133/1149 (11%)
Query: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARS-ARMYRDELDALRE 317
++ R +EL+ K E+LL K++ ++E EL+ +++++ LL + A + E + E
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 318 KAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL 377
+L ++ +E LHD+E +RVEE +E NQ+L K ++ ++ + D
Sbjct: 906 AEEMRARLAAKKQELEEILHDLE---SRVEEEEERNQILQNEKKKMQAHIQDLEEQLD-- 960
Query: 378 HELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS 437
E+E + K +L + E KI+++ EE + LE + + E + + + S
Sbjct: 961 ---EEEGARQKLQLEKVTAEA-----KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKME 497
S+L+E +K+ L K+ + + + +EE ++ K E
Sbjct: 1013 --SQLAEEEEKA----------KNLAKIRNKQEVMISDLEE-------------RLKKEE 1047
Query: 498 KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
K Q L K L+ E + + Q +L K QL K E L+ R +
Sbjct: 1048 KTRQELEKAKRKLDGETTDLQDQIAELQAQIDEL---KLQLAKKEEELQGALARG----D 1100
Query: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL 617
E H N + +R+ AE L E + + +K E +KR + +EL
Sbjct: 1101 DETLHKNNALKVVRELQAQIAE------------LQEDFESEKASRNKAEKQKRDLSEEL 1148
Query: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
E K ELE+ L + EL K+ + E +ALE+E E + + +++
Sbjct: 1149 EALKT------ELEDTLDTTAAQQELRTKREQEV---AELKKALEEETKNHEAQIQDMRQ 1199
Query: 678 T-LDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
+ + L+ QLE ++ + L++ L + + L C + Q++ E+ E ++++
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES---EHKRKK 1256
Query: 737 LKKGLELLKASFKKTERLEVSY----QGLDIENQRLQKTLENSNKK-------IQQLESE 785
L ++ L A + +RL V L E + LE + KK LES+
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
LQD + + LQ+ + S R+ QLE+E SL+++ + E+ +K LEK+ L+ Q
Sbjct: 1317 LQDTQ---ELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL 1373
Query: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGI----YKESCVRLKELEKENKELVKRATIDI 901
++++ I +LE+ K L K+ +E + +LEK L +
Sbjct: 1374 ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQEL---- 1429
Query: 902 KTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKL 961
+DL + +Q+ ++LEK + ++LL +E+S +RY +
Sbjct: 1430 -------DDLTVDLDHQRQVASNLEKKQKKF-------DQLLAEEKSI-SARYAEERDRA 1474
Query: 962 ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-----ERM 1016
E+ ++ KE K +L LEE+ ++ ++ K ++ + E L +D+ +
Sbjct: 1475 EAEARE----KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHEL 1530
Query: 1017 VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE-KQALKTQLKQLETQ 1075
+S + + + + +E EL +D + +E N ++A+ ++ L+T+ +Q E +
Sbjct: 1531 EKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEK 1590
Query: 1076 NNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSL 1135
L Q+ L+ + ++Q K++++ L +Q + +++ Q L
Sbjct: 1591 KRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKL 1650
Query: 1136 ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH 1195
+ + + +E E+ ++ D + ++ E + +E L + + + A ++ E E
Sbjct: 1651 QAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER 1710
Query: 1196 RDLEDRYNQLLKQKGQLEDLEKMLKVE----QEKMLLENKNHETVAAEYKKLCGENDRLN 1251
+L D K L D ++ L+ +E++ E N E + ++K + D LN
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN 1770
Query: 1252 HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE----AEFSKLKEQYQQLDITSTKLN 1307
++L E Q + L +K + +L+ A SK K L+ +L
Sbjct: 1771 ---AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1827
Query: 1308 NQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELR 1367
Q E ++ + + R +++ + +Q +E D + + + ++ +L+
Sbjct: 1828 EQLEQEAKERAAANKLVRRTEKKLKEIFMQ----VEDERRHADQYKEQMEKANARMKQLK 1883
Query: 1368 RQKEKLEEK 1376
RQ E+ EE+
Sbjct: 1884 RQLEEAEEE 1892
Score = 170 bits (430), Expect = 1e-41
Identities = 235/1036 (22%), Positives = 436/1036 (42%), Gaps = 125/1036 (12%)
Query: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSL 521
LL++ + + L EEL + ++ +ME+++Q+L ++ IL ++ E +
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 522 QNCQNLSKDLMKEKAQLEKTIETLR---ENSERQIKILEQENEHLNQTVSSLR------- 571
+ + L +K +LE+ + L E E + +IL+ E + + + L
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 572 ------QRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE 625
Q +++AEA++K +E+E +L + + + +E + +L +EK +
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 626 RAEELENELHHLEKENELLQKKITNLKITCEKIE-ALEQENSELERENRKLKKTLDSFK- 683
++ N+ + + E KK + EK + L+ E ++L+ + +L+ +D K
Sbjct: 1024 NLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKL 1083
Query: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ-------LENKELESEKEQ 736
L + E L+ ++ D+E L ++ ++ ++A+LQ + E +K
Sbjct: 1084 QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143
Query: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQR----LQKTLENSNKKIQQLESELQDLEME 792
L + LE LK + T + Q L + ++ L+K LE K E+++QD+
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK---NHEAQIQDMRQR 1200
Query: 793 NQT----LQKNLEELKISSKRLEQ----LEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
+ T L + LE+ K LE+ LE +NK L E L++ K + E + K+L Q
Sbjct: 1201 HATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ 1260
Query: 845 A-EIKDTTLEENNVKIGNLEKENK---------TLSKEI---GI-YKESCVRLKELEKEN 890
E+ E + +++ EK +K TL +E GI + + L+ ++
Sbjct: 1261 VQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT 1320
Query: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
+EL++ T L + L EK Q+ + E+ LEK L + L D +
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380
Query: 951 DSRYKLLESKLESTLKKSLEIKE------EKIAALEARLEESTNYNQQ-----------L 993
D +ES LE KK L+ E E+ A +LE++ N QQ
Sbjct: 1381 DDDLGTIES-LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQ 1439
Query: 994 RQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV-- 1051
RQ ++K + Q EE+ + S + E ++ E E++E + L + L E
Sbjct: 1440 RQVASNLEKKQKKFDQLLAEEKSI--SARYAEERDRAEAEAREKETKALSLARALEEALE 1497
Query: 1052 -----ERNNATLQAEKQALKT-------QLKQLETQNNNLQAQILALQRQTVSLQEQNTT 1099
ER N L+A+ + L + + +LE L+ Q+ ++ Q L+++
Sbjct: 1498 AKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQA 1557
Query: 1100 LQTQNAKLQVENSTLNSQ-STSLMNQNAQ------LLIQQ-SSLENENESVIKERE---- 1147
+ +L+V + +Q L ++ Q LLI+Q LE E E K+R
Sbjct: 1558 TEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVA 1617
Query: 1148 -------DLKSL----------YDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1190
DLK L D +IK KL+ + E E + + + K
Sbjct: 1618 SKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKE 1677
Query: 1191 LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRL 1250
E + + LE QL ++ E + + E++++ E N A+ L E RL
Sbjct: 1678 SEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS---ASGKSALLDEKRRL 1734
Query: 1251 NHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQC 1310
+QL +E E Q++ + L + L+ L AE + + Q+ D +L Q
Sbjct: 1735 EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQN 1794
Query: 1311 E----LLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1366
+ L +L+G ++ + + + ++ + Q LEQ + + + R+ KL E+
Sbjct: 1795 KELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEI 1854
Query: 1367 RRQKEKLEEKIMDQYK 1382
Q E E + DQYK
Sbjct: 1855 FMQVED-ERRHADQYK 1869
Score = 152 bits (383), Expect = 4e-36
Identities = 174/823 (21%), Positives = 368/823 (44%), Gaps = 117/823 (14%)
Query: 136 QKKEEFIERIQGLDF---DTKAAVAAHIQEVTHNQENVFDLQWM--EVTDMSQEDIEPLL 190
++K + E ++ L DT AA + T ++ V +L+ E T + I+ +
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR 1198
Query: 191 KNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTES----- 245
+ A L+ L ++ ++ L + + GL + + + C +++ ++
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLE-----TDNKELACEVKVLQQVKAESEHK 1253
Query: 246 RQHLSVELADAKAKIR---RLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302
R+ L ++ + AK+ RLR EL EK +L + EL+ + L+ +++ + DA
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKL---QNELDNVSTLLEEAEKKGIKFAKDA 1310
Query: 303 RSAR-MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE--DNQVLL-- 357
S +D + L+E+ + L S + + +E + ++ + EE ++ + QVL
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ 1370
Query: 358 ----ETKTMLEDQL--------------EGTRARSDKLHE-------LEKENLQLKAKLH 392
+TK ++D L + A S +L E LEK +L+ +L
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430
Query: 393 DMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH 452
D+ ++ D R+ L ++ + + S E ++ + E SL
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLAR 1490
Query: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512
+ E ++ + E +N+ L +E+L ++ D V N + ++EK + L ++VE +
Sbjct: 1491 ALEEALEAKE-EFERQNKQLRADMEDLMSSKDDVGKN---VHELEKSKRALEQQVEEMRT 1546
Query: 513 EIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
++ + + LQ ++ L ++ KAQ E+ ++T E +E + ++L ++ L +
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE 1606
Query: 569 SLRQRSQISAEAR------VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY-- 620
R++ ++ ++ +KD+E + + +++ E +L K++ + + ++ELE
Sbjct: 1607 DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 621 ---------KEKGERAEELENEL--------------HHLEKENELLQKKITNLKITCEK 657
KE ++ + LE E+ H E+E + L +ITN +
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN---SASG 1723
Query: 658 IEALEQENSELERENRKLKKTLDSFK-NLTFQLESLEKENSQLDEENLELRRNVESLKCA 716
AL E LE +L++ L+ + N+ + K Q+D N EL + + +
Sbjct: 1724 KSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKS 1783
Query: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKT-ERLEVSYQGLDIENQRLQKTLENS 775
QL+ +NKEL+++ ++L+ + K+ FK T LE L+ + ++ K +
Sbjct: 1784 DNARQQLERQNKELKAKLQELEGAV---KSKFKATISALEAKIGQLEEQLEQEAKERAAA 1840
Query: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835
NK +++ E +L+++ M+ + +++ ++ K EQ+EK N ++Q QLE+ +++
Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHADQYK------EQMEKANARMKQLKRQLEEAEEEAT 1894
Query: 836 KEN-KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK 877
+ N R + Q E+ D T + N+ LS+E+ K
Sbjct: 1895 RANASRRKLQRELDDAT------------EANEGLSREVSTLK 1925
Score = 110 bits (274), Expect = 2e-23
Identities = 163/730 (22%), Positives = 322/730 (44%), Gaps = 85/730 (11%)
Query: 720 MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI 779
+ Q+ + +EL+++ E+L K E + E +E +Q L E L + L+ +
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 780 QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEK--- 836
+ E L + Q L++ L +L+ R+E+ E+ N+ L+ E +++ + LE+
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLE---SRVEEEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 837 ENKRLRQQAEIKDTTLEENNVKIGN----LEKENKTLSKEIGIYKESCVRL-KELEKENK 891
E + RQ+ +++ T E K+ LE +N KE + ++ +L +E +
Sbjct: 961 EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE 1020
Query: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951
+ A I K V + + + E+LK + EK ELEK +R L E +
Sbjct: 1021 KAKNLAKIRNKQEVMISD--LEERLKKE------EKTRQELEK----AKRKLDGETTDLQ 1068
Query: 952 SRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQ 1011
+ L+++++ LK L KEE++ AR ++ T + LK V++ + + Q
Sbjct: 1069 DQIAELQAQIDE-LKLQLAKKEEELQGALARGDDETLHK---NNALKVVRELQAQIAELQ 1124
Query: 1012 DEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ----AEKQALKT 1067
++ ++S NK E++ ++ + EL +K L + A Q +Q +
Sbjct: 1125 EDFESEKAS------RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAE 1178
Query: 1068 QLKQLETQNNNLQAQILAL-QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA 1126
K LE + N +AQI + QR +L+E + Q + AK N N Q L N
Sbjct: 1179 LKKALEEETKNHEAQIQDMRQRHATALEELSE--QLEQAKRFKANLEKNKQ--GLETDNK 1234
Query: 1127 QLLIQQSSLENENESVIKEREDLKSLYDSL---IKDHEKLELLHERQASEYESLISKHGT 1183
+L + L+ +R+ L + L + + ++L + +AS+ ++ + T
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVST 1294
Query: 1184 -LKSAHK----------NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKN 1232
L+ A K +LE + +D ++ + +QK L ++ ++E+EK L+ +
Sbjct: 1295 LLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS--SRIRQLEEEKNSLQEQQ 1352
Query: 1233 HETVAAE---YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAE- 1288
E A K++ +L T ++ + +++ + K LL +++ RLE +
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA 1412
Query: 1289 --FSKLKEQ----YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLL 1342
+ KL++ Q+LD + L++Q Q+ NLE++ + + L+ + +++
Sbjct: 1413 LAYDKLEKTKNRLQQELDDLTVDLDHQ----RQVASNLEKKQK----KFDQLLAEEKSIS 1464
Query: 1343 EQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRK 1402
+ E +D E R+ K L R LEE + + +F R+ + M
Sbjct: 1465 ARYAEERDRAEAEAREKETKALSLAR---ALEEALEAKEEF------ERQNKQLRADMED 1515
Query: 1403 LIKSKKDINR 1412
L+ SK D+ +
Sbjct: 1516 LMSSKDDVGK 1525
Score = 96.3 bits (238), Expect = 2e-19
Identities = 139/602 (23%), Positives = 252/602 (41%), Gaps = 61/602 (10%)
Query: 808 KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867
K L Q+ ++ + L+ + +L K K++ K L + LEE N+ L+ E +
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901
Query: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
++ +E RL ++E +E++ ++ + L +EK K Q DLE+
Sbjct: 902 LFAEA----EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 928 LTHELEKIGLNKERLLHDEQSTDDSRYKLLESK-LESTLKKSLEIKEEKIAALEARLEES 986
E E + L E+ T +++ K +E + L + S IKE+K+ +E R+ E
Sbjct: 958 QLDEEE----GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKL--MEDRIAEC 1011
Query: 987 TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKD 1046
++ QL +E + K K R +E M+ + K E+ QE + K+
Sbjct: 1012 SS---QLAEEEEKAK---NLAKIRNKQEVMISD---LEERLKKEEKTRQELEKAKRKLDG 1062
Query: 1047 RLIEVERNNATLQAEKQALKTQLKQLETQ--------------NNNLQAQILALQRQTVS 1092
+++ A LQA+ LK QL + E + NN + LQ Q
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE 1122
Query: 1093 LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL 1152
LQE + + K + + L+ + +L + L ++ + +E +LK
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKA 1182
Query: 1153 YDSLIKDHE-KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ 1211
+ K+HE +++ + +R A+ E L + K NLE + LE +L +
Sbjct: 1183 LEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKV 1242
Query: 1212 LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL 1271
L+ +K E E + K + E E DRL +L ++ LQ + N+
Sbjct: 1243 LQ----QVKAESEH---KRKKLDAQVQELHAKVSEGDRLR---VELAEKASKLQNELDNV 1292
Query: 1272 KSLLNNSKLEQTRLEAEFSKLKEQYQQL-----DITSTKLN--NQCELLSQLKGNL---- 1320
+LL ++ + + + + L+ Q Q + T KLN ++ L + K +L
Sbjct: 1293 STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQ 1352
Query: 1321 --EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK--LNELRRQKEKLEEK 1376
EEE R L++ Q L LQ++ + DL +E + K L + ++LEEK
Sbjct: 1353 EEEEEARKNLEK-QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEK 1411
Query: 1377 IM 1378
+
Sbjct: 1412 AL 1413
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 199 bits (505), Expect = 3e-50
Identities = 251/1140 (22%), Positives = 514/1140 (45%), Gaps = 125/1140 (10%)
Query: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
++ R +E++ K ++L K+ ++ E ELK L+Q++ L + + +++L A E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQEQLQAETEL 909
Query: 319 AVRVDKLESEVSRYKERLHDI-EFYKARVEELKEDNQVL-LETKTM------LEDQLEGT 370
+++ ++ K+ L +I +AR+EE ++ Q L E K M LE+QLE
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 371 RARSDKLHELEKENLQLKAK--------LHDMEMERDMDRKKIEELMEENMTLEMAQKQS 422
A KL +LEK + K K + D + +RK +EE + + +T +A+++
Sbjct: 970 EAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD-LTTNLAEEEE 1027
Query: 423 MDESL-HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
++L L + E + E+ ++ E+ +L KLE + + + +L+
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR----KLEGDASDFHEQIADLQA 1083
Query: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKT 541
+ ++ +++ K+ + L + L++EI Q+ +L+ + L + + L+
Sbjct: 1084 QIAELK------MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 542 IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI-KETS 600
R +E+Q + L +E E L + + E R K E+E +L +++ +ET
Sbjct: 1138 -RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR-EQEVTVLKKALDEETR 1195
Query: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
S ++++ E RQ K + +E E+ E+ + +L+K + L+K+ +L ++
Sbjct: 1196 SHEAQVQ-EMRQ--KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL---AGELRV 1249
Query: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES----LKCA 716
L Q E+E + +KL+ + + L + E+ ++L+++ +L+ VES L A
Sbjct: 1250 LGQAKQEVEHKKKKLEAQV---QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306
Query: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
K +L K++ S QL+ ELL+ ++ + + L+ E LQ L+
Sbjct: 1307 EGKAIKLA---KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1363
Query: 777 KKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ----LEKENKSLEQETSQLEKDKK 832
+ Q LE + L ++ +K L++ + + LE+ +KE ++L Q+ +
Sbjct: 1364 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1423
Query: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEK----------ENKTLSKEIGIYKE---- 878
+LEK RL+Q+ + L+ + NLEK E K +S + ++
Sbjct: 1424 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483
Query: 879 ----------SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK- 927
S R E E KE ++R K L EDLVS K + ++LEK
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTN---KMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 928 ---LTHELEKIGLNKERLLHDEQSTDDSRYKL------LESKLESTLKKSLEIKEEKIAA 978
L ++E++ E L + Q+T+D++ +L L+ + E L+ E EEK
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600
Query: 979 LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE--ERMVQSSPPISGEDNKWERESQE 1036
L+ +L E Y +L E K A K+ + + + +Q+ I G +E
Sbjct: 1601 LQRQLHE---YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR--------EE 1649
Query: 1037 TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096
++L K++ ++ + +R +A + + K+ E + +L+A ++ LQ + +
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1709
Query: 1097 NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1156
+ +L E ++ S +L ++ +L + + LE E E +E+ +++++ D +
Sbjct: 1710 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE---EEQGNMEAMSDRV 1766
Query: 1157 IKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL---LKQK---- 1209
K ++ E L A+E S K+ +SA + LE ++++L + +++ +K K
Sbjct: 1767 RKATQQAEQLSNELATE-RSTAQKN---ESARQQLERQNKELRSKLHEMEGAVKSKFKST 1822
Query: 1210 -----GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1264
++ LE+ ++ E + K+ + + K++ + + Q ++ E
Sbjct: 1823 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1882
Query: 1265 QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL-SQLKGNLEEE 1323
K LK L ++ E R+ A KL+ + + ++ + + L S+L+G +E
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQE 1942
Score = 180 bits (456), Expect = 1e-44
Identities = 234/1095 (21%), Positives = 468/1095 (42%), Gaps = 142/1095 (12%)
Query: 364 EDQLEGTRARSDK----LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
ED+L+ T+ R K L ELE+++ QL + + ++ + + + E E + L A+
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA-AK 923
Query: 420 KQSMDESLH-LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
KQ ++E LH + LE+ + +A +K + ++ +L +LE E + K E
Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE----QLEEEEAARQKLQLE 979
Query: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
T ++ +IL M+ +N +LSK+ ++LE I +L + +K+L K K +
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 539 EKTIETL----------RENSERQIKILEQENEHLNQTVSSLRQR--------------- 573
E I L R+ E+ + LE + ++ ++ L+ +
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1099
Query: 574 ------------SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK 621
+ +A +++++E L E + + +K E +KR + +ELE K
Sbjct: 1100 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159
Query: 622 EKGERAEELENELHHLEKENELLQKK---ITNLKITCEKIEALEQENSELERENRKLK-K 677
ELE+ L + EL K+ +T LK +AL++E E + ++++ K
Sbjct: 1160 ------TELEDTLDSTATQQELRAKREQEVTVLK------KALDEETRSHEAQVQEMRQK 1207
Query: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
+ + LT QLE ++ + LD+ L + L + ++ L +E+E +K++L
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL---AGELRVLGQAKQEVEHKKKKL 1264
Query: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN--------------KKIQQLE 783
+ ++ L++ ER L+ + +LQ +E+ K + L
Sbjct: 1265 EAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 784 SELQDLE--MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
S+LQD + ++ +T QK L +S+K L QLE+E SL+ + + + K+ LE+ L
Sbjct: 1322 SQLQDTQELLQEETRQK----LNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 842 RQQAEIKDTTLEENNVKIGNLEKENKTLSKEI----GIYKESCVRLKELEKENKELVKRA 897
Q L++ + LE+ K KEI Y+E +LEK L +
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLL 957
+DLV + +Q+ ++LEK + ++ L E+ S+Y
Sbjct: 1437 -----------DDLVVDLDNQRQLVSNLEKKQRKFDQ--------LLAEEKNISSKYADE 1477
Query: 958 ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1017
+ E+ ++ KE K +L LEE+ ++L + K +K E L +D+ +
Sbjct: 1478 RDRAEAEARE----KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD--VG 1531
Query: 1018 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL-------- 1069
++ + E + +E +L +++D L E L+ QALK Q
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 1070 KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL 1129
+Q E + LQ Q+ + + ++Q KL+ + L Q+ S + + +
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 1130 IQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHK 1189
Q L+ + + +E ED ++ D + ++ E + ++ L + A K
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 1190 NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE----QEKMLLENKNHETVAAEYKKLCG 1245
++E +L + L + L+D ++ L+ +E++ E N E ++ +K
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 1246 ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE----AEFSKLKEQYQQLDI 1301
+ ++L+ ++L E Q + + L +K +++L A SK K L+
Sbjct: 1772 QAEQLS---NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 1302 TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID 1361
+L Q E ++ K + + +++ ++LQ +E + + + + +
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ----VEDERKMAEQYKEQAEKGNA 1884
Query: 1362 KLNELRRQKEKLEEK 1376
++ +L+RQ E+ EE+
Sbjct: 1885 RVKQLKRQLEEAEEE 1899
Score = 176 bits (447), Expect = 1e-43
Identities = 232/991 (23%), Positives = 443/991 (44%), Gaps = 102/991 (10%)
Query: 198 KRLIDER-DEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADA 256
++L++ER + + + E E+ L L + S S K +SRQ L
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE------ 1061
Query: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
K K R+L + + EQ+ D + ++ +++++L + ++E A AR+ DE+
Sbjct: 1062 KLK-RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAALARL-DDEIAQKN 1114
Query: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET-KTMLEDQLEGTRARSD 375
++ +LE +S +E L + + E+ K D LE KT LED L+ T + +
Sbjct: 1115 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174
Query: 376 KLHELEKENLQLKAKL------HDMEME--RDMDRKKIEELMEENMTLEMAQ------KQ 421
+ E+E LK L H+ +++ R + +EEL E+ + A+ KQ
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 422 SMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
+++ E+ L EL + + + E +K L +V EL S+ E L V +L+
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL-QSKCSDGERARAELNDKVHKLQ 1293
Query: 481 TTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
V+SV G + K +K+ K+ LS +++ + + +E + N + L +E+
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 537 QLEKTIET---LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
L+ ++ ++N ER I L + + + + E + K +KE + L
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK-KRFQKEIENLT 1412
Query: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE--LLQKKITNL 651
+ +E ++ K+E K ++++EL+ + +L + L +++ + L ++K +
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
K E+ A E E E E + L + L+ E LE+ N L E +L V
Sbjct: 1473 KYADERDRA-EAEAREKETKALSLARALEEALEAK---EELERTNKMLKAEMEDL---VS 1525
Query: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE----RLEVSYQGLDIENQR 767
S + +L+ + LE++ E++K LE L+ + TE RLEV+ Q L + +R
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 768 -LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ 826
LQ E + +K +QL+ +L + E E L+ ++ +++ ++LE + K LE +
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETE---LEDERKQRALAAAAKKKLEGDLKDLELQADS 1642
Query: 827 LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKEL 886
K +++ K+ ++L QA++KD E LE + + KE+ + K L
Sbjct: 1643 AIKGREEAIKQLRKL--QAQMKDFQRE--------LEDARASRDEIFATAKENEKKAKSL 1692
Query: 887 EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE 946
E + L+ L+EDL + + +Q + + E+L EL L+ L DE
Sbjct: 1693 EAD--------------LMQLQEDLAAAERARKQADLEKEELAEELAS-SLSGRNALQDE 1737
Query: 947 QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL----KTVKK 1002
+ ++R LE +LE ++ + A+ R+ ++T +QL EL T +K
Sbjct: 1738 KRRLEARIAQLEEELEE--------EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 1003 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1062
N A +Q + + + ++S E + ++T L+ K + ++E EK
Sbjct: 1790 NESARQQLERQNKELRSK---LHEMEGAVKSKFKSTIAALEAK--IAQLEEQVEQEAREK 1844
Query: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ--NTTLQTQNAKLQVENSTLNSQSTS 1120
QA LKQ + + + Q+ ++ +EQ + + K Q+E + SQ +
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Query: 1121 LMNQNAQLLIQQSSLENENESVIKEREDLKS 1151
+ Q + +++ NE++ +E LKS
Sbjct: 1905 ANRRKLQRELDEAT--ESNEAMGREVNALKS 1933
Score = 146 bits (369), Expect = 2e-34
Identities = 203/847 (23%), Positives = 361/847 (42%), Gaps = 99/847 (11%)
Query: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
EE++ + L+K E QK LK LEQ++S+L E L++ L + L
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELK-------ELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 688 QLES----LEKENSQLDEENLELRRNVES-------LKCASMKMAQLQLENKELESEKEQ 736
+ E L + +L+E E+ +E L+ KMAQ L+ +E E+E
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 737 LKKGLELLKASFK-KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE--MEN 793
++ L+L K + + K ++LE +D +N +L K + ++I L + L + E +N
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 794 QTLQKNLEELKISSK--RLEQLEKENKSLEQETSQLEKD------------------KKQ 833
T KN E IS RL++ EK + LE+ +LE D K Q
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 834 LEKENKRLRQQ-AEIKDTTLEENNV--KIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
L K+ + L+ A + D ++NN KI LE L +++ E R K EK+
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD--SERAARNKA-EKQK 1148
Query: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
++L + +++ L T ED + Q++ E+ L+K L++E H+ Q
Sbjct: 1149 RDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQ-VQ 1202
Query: 951 DSRYKLLESKLEST--------LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1002
+ R K ++ E T K +L+ ++ + A L Q +QE++ KK
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 1003 NYEALKQR-----QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
EA Q D ER + ++ + +K + E + T L + + + I++ ++ A+
Sbjct: 1263 KLEAQVQELQSKCSDGER---ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
L ++ Q + L++ Q N+ ++ L+ + SLQ+Q L+ STLN Q
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 1118 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1177
+ + +LE + KE E+L Y+ ++KLE R E + L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 1178 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1237
+ + NLE + R +++QLL ++ +++ E+++ E + ET A
Sbjct: 1440 VVDLDNQRQLVSNLEKKQR----KFDQLLAEE---KNISSKYADERDRAEAEAREKETKA 1492
Query: 1238 AEYKKLCGE----NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1293
+ E + L T L E E L + ++ ++ + + LE + ++K
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 1294 EQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFH 1353
Q ++L+ ++ + K LE + L Q + LQ R EQN E +
Sbjct: 1553 TQLEELE-------DELQATEDAKLRLEVNMQALKGQFER-DLQARD--EQNEEKRRQLQ 1602
Query: 1354 VEQRQYIDKLNELRRQ-------KEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKS 1406
+ +Y +L + R+Q K+KLE + D D + R ++RKL
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE--AIKQLRKLQAQ 1660
Query: 1407 KKDINRE 1413
KD RE
Sbjct: 1661 MKDFQRE 1667
Score = 140 bits (353), Expect = 1e-32
Identities = 199/942 (21%), Positives = 416/942 (44%), Gaps = 97/942 (10%)
Query: 502 RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENE 561
R ++++ E+E+ + K+ Q +N K+L ++ +QL + L+E + + ++ + E
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 562 HLNQTVSSLRQRSQI--SAEARVKDIEKENKILHESIKETSSKLSKIE---FEKRQIKKE 616
+ + ++ +I EAR+++ E + L K+ + ++ +E E+ +++
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 617 LEHYKEKGE-RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
L+ K E + ++LE+E+ ++ +N L K+ K+ E+I L +E E + + L
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE---RKLLEERISDLTTNLAEEEEKAKNL 1032
Query: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE-------------SLKCASMKMAQ 722
K + +++ +LE K+ + +E +L+R +E + A +KM Q
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM-Q 1091
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL--DIENQRLQKTLENSNKKIQ 780
L + +EL++ +L + + KK LE L D++++R + + K+ +
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR--NKAEKQKR 1149
Query: 781 QLESELQDLEME-NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENK 839
L EL+ L+ E TL + ++ +KR +++ K+L++ET E Q+++ +
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE---AQVQEMRQ 1206
Query: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATI 899
+ Q E LE+ NL+K +TL KE L + ++E + K+
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI-GLNKERLLHDEQSTDDSRYKLLE 958
++ L + D E+ + ++N+ + KL +E+E + G+ E + KL +
Sbjct: 1267 QVQELQSKCSD--GERARA-ELNDKVHKLQNEVESVTGMLNE--------AEGKAIKLAK 1315
Query: 959 --SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY-EALKQRQDEER 1015
+ L S L+ + E+ +E+ +L ST +QL +E +++ E ++ +Q+ ER
Sbjct: 1316 DVASLSSQLQDTQELLQEE---TRQKLNVSTKL-RQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 1016 MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1075
+ S+ I D+K + + +T E L+ + + E N T Q E++A +LE
Sbjct: 1372 HI-STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA--AAYDKLEKT 1428
Query: 1076 NNNLQAQI------LALQRQTVS-------------LQEQNTTLQ--TQNAKLQVENSTL 1114
N LQ ++ L QRQ VS +E+N + + + + + E
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 1115 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD-------SLIKDHEKLELLH 1167
+++ SL + L + LE N+ + E EDL S D L K LE
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 1168 ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED-----LEKMLKVE 1222
E ++ E L + + A LEV + L+ ++ + L+ + + + L++ L
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 1223 QEKMLLENKNHETVAAEYKKLCG-------ENDRLNHTYSQLLKETEVLQTDHKNLKSLL 1275
+ ++ E K AA KKL G + D + +K+ LQ K+ + L
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 1276 NNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLM 1335
+++ + + A + +++ + L+ +L + + + E L +++ +
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS-S 1727
Query: 1336 LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
L R L+ + K Q ++L E + E + +++
Sbjct: 1728 LSGRNALQ---DEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Score = 130 bits (327), Expect = 1e-29
Identities = 180/799 (22%), Positives = 350/799 (43%), Gaps = 117/799 (14%)
Query: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK----EQLKKGLELL 744
L + ++ ++ + EL++ E + A ++ +L+ ++ +L EK EQL+ EL
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
+ + RL Q L+ ++ LE + QQL++E + + + L++ LEE +
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 805 ISSKRLEQLEK-----ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
+ ++L QLEK + K LE E ++ +L KE K L ++ T L E K
Sbjct: 971 AARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK-------------------RATI- 899
NL K +K + E VRLK+ EK +EL K +A I
Sbjct: 1030 KNL---TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 900 DIKTLVTLREDLVSEKL-----KTQQMNNDLEKLTHELE------KIGLNKERLLH---D 945
++K + +E+ + L + Q NN L+K+ ELE + L+ ER +
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEGHISDLQEDLDSERAARNKAE 1145
Query: 946 EQSTD-DSRYKLLESKLESTL-----KKSLEIK-EEKIAALEARLEESTNYNQQLRQELK 998
+Q D + L+++LE TL ++ L K E+++ L+ L+E T ++ QE++
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Query: 999 TVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
+K+ +A+++ ++ E+ ++ + E+E+ + EL + EVE
Sbjct: 1206 --QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
L+A+ Q L+++ E L ++ LQ + S+ + + KL + ++L+SQ
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 1118 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1177
Q+ Q L+Q+ + + N S KL L E + S + L
Sbjct: 1324 L-----QDTQELLQEETRQKLNVST-------------------KLRQLEEERNSLQDQL 1359
Query: 1178 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1237
+ A +NLE R + QL K +L+D ++ +E K E +
Sbjct: 1360 DEE----MEAKQNLE---RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 1238 AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE---AEFSKLKE 1294
+Y++ D+L T ++L +E + L D N + L++N + +Q + + AE +
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 1295 QY-----------QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1343
+Y ++ + + L E + K LE N+ L +++ L+ +
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-- 1530
Query: 1344 QNMESKDLFHVE--QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK-- 1399
K++ +E +R ++ E++ Q E+LE D+ + + + R N LK
Sbjct: 1531 ----GKNVHELEKSKRALETQMEEMKTQLEELE----DELQATEDAKLRLEVNMQALKGQ 1582
Query: 1400 MRKLIKSKKDINRERQKSL 1418
+ ++++ + N E+++ L
Sbjct: 1583 FERDLQARDEQNEEKRRQL 1601
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 199 bits (505), Expect = 3e-50
Identities = 251/1140 (22%), Positives = 514/1140 (45%), Gaps = 125/1140 (10%)
Query: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
++ R +E++ K ++L K+ ++ E ELK L+Q++ L + + +++L A E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQEQLQAETEL 902
Query: 319 AVRVDKLESEVSRYKERLHDI-EFYKARVEELKEDNQVL-LETKTM------LEDQLEGT 370
+++ ++ K+ L +I +AR+EE ++ Q L E K M LE+QLE
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 371 RARSDKLHELEKENLQLKAK--------LHDMEMERDMDRKKIEELMEENMTLEMAQKQS 422
A KL +LEK + K K + D + +RK +EE + + +T +A+++
Sbjct: 963 EAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD-LTTNLAEEEE 1020
Query: 423 MDESL-HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
++L L + E + E+ ++ E+ +L KLE + + + +L+
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR----KLEGDASDFHEQIADLQA 1076
Query: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKT 541
+ ++ +++ K+ + L + L++EI Q+ +L+ + L + + L+
Sbjct: 1077 QIAELK------MQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 542 IETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI-KETS 600
R +E+Q + L +E E L + + E R K E+E +L +++ +ET
Sbjct: 1131 -RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR-EQEVTVLKKALDEETR 1188
Query: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
S ++++ E RQ K + +E E+ E+ + +L+K + L+K+ +L ++
Sbjct: 1189 SHEAQVQ-EMRQ--KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL---AGELRV 1242
Query: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES----LKCA 716
L Q E+E + +KL+ + + L + E+ ++L+++ +L+ VES L A
Sbjct: 1243 LGQAKQEVEHKKKKLEAQV---QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299
Query: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
K +L K++ S QL+ ELL+ ++ + + L+ E LQ L+
Sbjct: 1300 EGKAIKLA---KDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEM 1356
Query: 777 KKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ----LEKENKSLEQETSQLEKDKK 832
+ Q LE + L ++ +K L++ + + LE+ +KE ++L Q+ +
Sbjct: 1357 EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD 1416
Query: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEK----------ENKTLSKEIGIYKE---- 878
+LEK RL+Q+ + L+ + NLEK E K +S + ++
Sbjct: 1417 KLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476
Query: 879 ----------SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK- 927
S R E E KE ++R K L EDLVS K + ++LEK
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTN---KMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 928 ---LTHELEKIGLNKERLLHDEQSTDDSRYKL------LESKLESTLKKSLEIKEEKIAA 978
L ++E++ E L + Q+T+D++ +L L+ + E L+ E EEK
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593
Query: 979 LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE--ERMVQSSPPISGEDNKWERESQE 1036
L+ +L E Y +L E K A K+ + + + +Q+ I G +E
Sbjct: 1594 LQRQLHE---YETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR--------EE 1642
Query: 1037 TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096
++L K++ ++ + +R +A + + K+ E + +L+A ++ LQ + +
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERA 1702
Query: 1097 NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1156
+ +L E ++ S +L ++ +L + + LE E E +E+ +++++ D +
Sbjct: 1703 RKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE---EEQGNMEAMSDRV 1759
Query: 1157 IKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL---LKQK---- 1209
K ++ E L A+E S K+ +SA + LE ++++L + +++ +K K
Sbjct: 1760 RKATQQAEQLSNELATE-RSTAQKN---ESARQQLERQNKELRSKLHEMEGAVKSKFKST 1815
Query: 1210 -----GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1264
++ LE+ ++ E + K+ + + K++ + + Q ++ E
Sbjct: 1816 IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG 1875
Query: 1265 QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL-SQLKGNLEEE 1323
K LK L ++ E R+ A KL+ + + ++ + + L S+L+G +E
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQE 1935
Score = 180 bits (456), Expect = 1e-44
Identities = 234/1095 (21%), Positives = 468/1095 (42%), Gaps = 142/1095 (12%)
Query: 364 EDQLEGTRARSDK----LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
ED+L+ T+ R K L ELE+++ QL + + ++ + + + E E + L A+
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA-AK 916
Query: 420 KQSMDESLH-LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
KQ ++E LH + LE+ + +A +K + ++ +L +LE E + K E
Sbjct: 917 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE----QLEEEEAARQKLQLE 972
Query: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
T ++ +IL M+ +N +LSK+ ++LE I +L + +K+L K K +
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 539 EKTIETL----------RENSERQIKILEQENEHLNQTVSSLRQR--------------- 573
E I L R+ E+ + LE + ++ ++ L+ +
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1092
Query: 574 ------------SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK 621
+ +A +++++E L E + + +K E +KR + +ELE K
Sbjct: 1093 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152
Query: 622 EKGERAEELENELHHLEKENELLQKK---ITNLKITCEKIEALEQENSELERENRKLK-K 677
ELE+ L + EL K+ +T LK +AL++E E + ++++ K
Sbjct: 1153 ------TELEDTLDSTATQQELRAKREQEVTVLK------KALDEETRSHEAQVQEMRQK 1200
Query: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
+ + LT QLE ++ + LD+ L + L + ++ L +E+E +K++L
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL---AGELRVLGQAKQEVEHKKKKL 1257
Query: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN--------------KKIQQLE 783
+ ++ L++ ER L+ + +LQ +E+ K + L
Sbjct: 1258 EAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 784 SELQDLE--MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
S+LQD + ++ +T QK L +S+K L QLE+E SL+ + + + K+ LE+ L
Sbjct: 1315 SQLQDTQELLQEETRQK----LNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 842 RQQAEIKDTTLEENNVKIGNLEKENKTLSKEI----GIYKESCVRLKELEKENKELVKRA 897
Q L++ + LE+ K KEI Y+E +LEK L +
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLL 957
+DLV + +Q+ ++LEK + ++ L E+ S+Y
Sbjct: 1430 -----------DDLVVDLDNQRQLVSNLEKKQRKFDQ--------LLAEEKNISSKYADE 1470
Query: 958 ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1017
+ E+ ++ KE K +L LEE+ ++L + K +K E L +D+ +
Sbjct: 1471 RDRAEAEARE----KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD--VG 1524
Query: 1018 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL-------- 1069
++ + E + +E +L +++D L E L+ QALK Q
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 1070 KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL 1129
+Q E + LQ Q+ + + ++Q KL+ + L Q+ S + + +
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 1130 IQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHK 1189
Q L+ + + +E ED ++ D + ++ E + ++ L + A K
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 1190 NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE----QEKMLLENKNHETVAAEYKKLCG 1245
++E +L + L + L+D ++ L+ +E++ E N E ++ +K
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 1246 ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE----AEFSKLKEQYQQLDI 1301
+ ++L+ ++L E Q + + L +K +++L A SK K L+
Sbjct: 1765 QAEQLS---NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821
Query: 1302 TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID 1361
+L Q E ++ K + + +++ ++LQ +E + + + + +
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ----VEDERKMAEQYKEQAEKGNA 1877
Query: 1362 KLNELRRQKEKLEEK 1376
++ +L+RQ E+ EE+
Sbjct: 1878 RVKQLKRQLEEAEEE 1892
Score = 176 bits (447), Expect = 1e-43
Identities = 232/991 (23%), Positives = 443/991 (44%), Gaps = 102/991 (10%)
Query: 198 KRLIDER-DEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADA 256
++L++ER + + + E E+ L L + S S K +SRQ L
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE------ 1054
Query: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
K K R+L + + EQ+ D + ++ +++++L + ++E A AR+ DE+
Sbjct: 1055 KLK-RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAALARL-DDEIAQKN 1107
Query: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET-KTMLEDQLEGTRARSD 375
++ +LE +S +E L + + E+ K D LE KT LED L+ T + +
Sbjct: 1108 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167
Query: 376 KLHELEKENLQLKAKL------HDMEME--RDMDRKKIEELMEENMTLEMAQ------KQ 421
+ E+E LK L H+ +++ R + +EEL E+ + A+ KQ
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 422 SMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
+++ E+ L EL + + + E +K L +V EL S+ E L V +L+
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL-QSKCSDGERARAELNDKVHKLQ 1286
Query: 481 TTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
V+SV G + K +K+ K+ LS +++ + + +E + N + L +E+
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 537 QLEKTIET---LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
L+ ++ ++N ER I L + + + + E + K +KE + L
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK-KRFQKEIENLT 1405
Query: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE--LLQKKITNL 651
+ +E ++ K+E K ++++EL+ + +L + L +++ + L ++K +
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
K E+ A E E E E + L + L+ E LE+ N L E +L V
Sbjct: 1466 KYADERDRA-EAEAREKETKALSLARALEEALEAK---EELERTNKMLKAEMEDL---VS 1518
Query: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE----RLEVSYQGLDIENQR 767
S + +L+ + LE++ E++K LE L+ + TE RLEV+ Q L + +R
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 768 -LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ 826
LQ E + +K +QL+ +L + E E L+ ++ +++ ++LE + K LE +
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETE---LEDERKQRALAAAAKKKLEGDLKDLELQADS 1635
Query: 827 LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKEL 886
K +++ K+ ++L QA++KD E LE + + KE+ + K L
Sbjct: 1636 AIKGREEAIKQLRKL--QAQMKDFQRE--------LEDARASRDEIFATAKENEKKAKSL 1685
Query: 887 EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE 946
E + L+ L+EDL + + +Q + + E+L EL L+ L DE
Sbjct: 1686 EAD--------------LMQLQEDLAAAERARKQADLEKEELAEELAS-SLSGRNALQDE 1730
Query: 947 QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL----KTVKK 1002
+ ++R LE +LE ++ + A+ R+ ++T +QL EL T +K
Sbjct: 1731 KRRLEARIAQLEEELEE--------EQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 1003 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1062
N A +Q + + + ++S E + ++T L+ K + ++E EK
Sbjct: 1783 NESARQQLERQNKELRSK---LHEMEGAVKSKFKSTIAALEAK--IAQLEEQVEQEAREK 1837
Query: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ--NTTLQTQNAKLQVENSTLNSQSTS 1120
QA LKQ + + + Q+ ++ +EQ + + K Q+E + SQ +
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Query: 1121 LMNQNAQLLIQQSSLENENESVIKEREDLKS 1151
+ Q + +++ NE++ +E LKS
Sbjct: 1898 ANRRKLQRELDEAT--ESNEAMGREVNALKS 1926
Score = 146 bits (369), Expect = 2e-34
Identities = 203/847 (23%), Positives = 361/847 (42%), Gaps = 99/847 (11%)
Query: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
EE++ + L+K E QK LK LEQ++S+L E L++ L + L
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELK-------ELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 688 QLES----LEKENSQLDEENLELRRNVES-------LKCASMKMAQLQLENKELESEKEQ 736
+ E L + +L+E E+ +E L+ KMAQ L+ +E E+E
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 737 LKKGLELLKASFK-KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE--MEN 793
++ L+L K + + K ++LE +D +N +L K + ++I L + L + E +N
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 794 QTLQKNLEELKISSK--RLEQLEKENKSLEQETSQLEKD------------------KKQ 833
T KN E IS RL++ EK + LE+ +LE D K Q
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 834 LEKENKRLRQQ-AEIKDTTLEENNV--KIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
L K+ + L+ A + D ++NN KI LE L +++ E R K EK+
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD--SERAARNKA-EKQK 1141
Query: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
++L + +++ L T ED + Q++ E+ L+K L++E H+ Q
Sbjct: 1142 RDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQ-VQ 1195
Query: 951 DSRYKLLESKLEST--------LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1002
+ R K ++ E T K +L+ ++ + A L Q +QE++ KK
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 1003 NYEALKQR-----QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
EA Q D ER + ++ + +K + E + T L + + + I++ ++ A+
Sbjct: 1256 KLEAQVQELQSKCSDGER---ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
L ++ Q + L++ Q N+ ++ L+ + SLQ+Q L+ STLN Q
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 1118 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1177
+ + +LE + KE E+L Y+ ++KLE R E + L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 1178 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1237
+ + NLE + R +++QLL ++ +++ E+++ E + ET A
Sbjct: 1433 VVDLDNQRQLVSNLEKKQR----KFDQLLAEE---KNISSKYADERDRAEAEAREKETKA 1485
Query: 1238 AEYKKLCGE----NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1293
+ E + L T L E E L + ++ ++ + + LE + ++K
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 1294 EQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFH 1353
Q ++L+ ++ + K LE + L Q + LQ R EQN E +
Sbjct: 1546 TQLEELE-------DELQATEDAKLRLEVNMQALKGQFER-DLQARD--EQNEEKRRQLQ 1595
Query: 1354 VEQRQYIDKLNELRRQ-------KEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKS 1406
+ +Y +L + R+Q K+KLE + D D + R ++RKL
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE--AIKQLRKLQAQ 1653
Query: 1407 KKDINRE 1413
KD RE
Sbjct: 1654 MKDFQRE 1660
Score = 140 bits (353), Expect = 1e-32
Identities = 199/942 (21%), Positives = 416/942 (44%), Gaps = 97/942 (10%)
Query: 502 RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENE 561
R ++++ E+E+ + K+ Q +N K+L ++ +QL + L+E + + ++ + E
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 562 HLNQTVSSLRQRSQI--SAEARVKDIEKENKILHESIKETSSKLSKIE---FEKRQIKKE 616
+ + ++ +I EAR+++ E + L K+ + ++ +E E+ +++
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 617 LEHYKEKGE-RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
L+ K E + ++LE+E+ ++ +N L K+ K+ E+I L +E E + + L
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE---RKLLEERISDLTTNLAEEEEKAKNL 1025
Query: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE-------------SLKCASMKMAQ 722
K + +++ +LE K+ + +E +L+R +E + A +KM Q
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM-Q 1084
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL--DIENQRLQKTLENSNKKIQ 780
L + +EL++ +L + + KK LE L D++++R + + K+ +
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR--NKAEKQKR 1142
Query: 781 QLESELQDLEME-NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENK 839
L EL+ L+ E TL + ++ +KR +++ K+L++ET E Q+++ +
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE---AQVQEMRQ 1199
Query: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATI 899
+ Q E LE+ NL+K +TL KE L + ++E + K+
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI-GLNKERLLHDEQSTDDSRYKLLE 958
++ L + D E+ + ++N+ + KL +E+E + G+ E + KL +
Sbjct: 1260 QVQELQSKCSD--GERARA-ELNDKVHKLQNEVESVTGMLNE--------AEGKAIKLAK 1308
Query: 959 --SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY-EALKQRQDEER 1015
+ L S L+ + E+ +E+ +L ST +QL +E +++ E ++ +Q+ ER
Sbjct: 1309 DVASLSSQLQDTQELLQEE---TRQKLNVSTKL-RQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 1016 MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1075
+ S+ I D+K + + +T E L+ + + E N T Q E++A +LE
Sbjct: 1365 HI-STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA--AAYDKLEKT 1421
Query: 1076 NNNLQAQI------LALQRQTVS-------------LQEQNTTLQ--TQNAKLQVENSTL 1114
N LQ ++ L QRQ VS +E+N + + + + + E
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 1115 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD-------SLIKDHEKLELLH 1167
+++ SL + L + LE N+ + E EDL S D L K LE
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 1168 ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED-----LEKMLKVE 1222
E ++ E L + + A LEV + L+ ++ + L+ + + + L++ L
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 1223 QEKMLLENKNHETVAAEYKKLCG-------ENDRLNHTYSQLLKETEVLQTDHKNLKSLL 1275
+ ++ E K AA KKL G + D + +K+ LQ K+ + L
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 1276 NNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLM 1335
+++ + + A + +++ + L+ +L + + + E L +++ +
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS-S 1720
Query: 1336 LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
L R L+ + K Q ++L E + E + +++
Sbjct: 1721 LSGRNALQ---DEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Score = 130 bits (327), Expect = 1e-29
Identities = 180/799 (22%), Positives = 350/799 (43%), Gaps = 117/799 (14%)
Query: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK----EQLKKGLELL 744
L + ++ ++ + EL++ E + A ++ +L+ ++ +L EK EQL+ EL
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
+ + RL Q L+ ++ LE + QQL++E + + + L++ LEE +
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 805 ISSKRLEQLEK-----ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
+ ++L QLEK + K LE E ++ +L KE K L ++ T L E K
Sbjct: 964 AARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK-------------------RATI- 899
NL K +K + E VRLK+ EK +EL K +A I
Sbjct: 1023 KNL---TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 900 DIKTLVTLREDLVSEKL-----KTQQMNNDLEKLTHELE------KIGLNKERLLH---D 945
++K + +E+ + L + Q NN L+K+ ELE + L+ ER +
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEGHISDLQEDLDSERAARNKAE 1138
Query: 946 EQSTD-DSRYKLLESKLESTL-----KKSLEIK-EEKIAALEARLEESTNYNQQLRQELK 998
+Q D + L+++LE TL ++ L K E+++ L+ L+E T ++ QE++
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 999 TVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
+K+ +A+++ ++ E+ ++ + E+E+ + EL + EVE
Sbjct: 1199 --QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
L+A+ Q L+++ E L ++ LQ + S+ + + KL + ++L+SQ
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 1118 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1177
Q+ Q L+Q+ + + N S KL L E + S + L
Sbjct: 1317 L-----QDTQELLQEETRQKLNVST-------------------KLRQLEEERNSLQDQL 1352
Query: 1178 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1237
+ A +NLE R + QL K +L+D ++ +E K E +
Sbjct: 1353 DEE----MEAKQNLE---RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 1238 AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE---AEFSKLKE 1294
+Y++ D+L T ++L +E + L D N + L++N + +Q + + AE +
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 1295 QY-----------QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1343
+Y ++ + + L E + K LE N+ L +++ L+ +
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-- 1523
Query: 1344 QNMESKDLFHVE--QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK-- 1399
K++ +E +R ++ E++ Q E+LE D+ + + + R N LK
Sbjct: 1524 ----GKNVHELEKSKRALETQMEEMKTQLEELE----DELQATEDAKLRLEVNMQALKGQ 1575
Query: 1400 MRKLIKSKKDINRERQKSL 1418
+ ++++ + N E+++ L
Sbjct: 1576 FERDLQARDEQNEEKRRQL 1594
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 197 bits (502), Expect = 6e-50
Identities = 263/1120 (23%), Positives = 502/1120 (44%), Gaps = 162/1120 (14%)
Query: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
++ R +E++ K ++L K+ ++ E ELK L+Q++ L + + +++L A E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQEQLQAETEL 902
Query: 319 AVRVDKLESEVSRYKERLHDI-EFYKARVEELKEDNQVL-LETKTM------LEDQLEGT 370
+++ ++ K+ L +I +AR+EE ++ Q L E K M LE+QLE
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 371 RARSDKLHELEKENLQLKAK--------LHDMEMERDMDRKKIEE--------LMEE--- 411
A KL +LEK + K K + D + +RK +EE L EE
Sbjct: 963 EAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 412 --NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG-----HEVNELTSSRLLK 464
N+T + +SM L + + E+ SR EL + +K G HE +++ +
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
L+M+ L K EEL+ + ++ ++ K+ + L + L+ ++ E+ +
Sbjct: 1081 LKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 525 QNLSKDLMKE----KAQLEKTIET------LRENSERQI----KILEQENEHLNQTVSSL 570
+ +DL +E K +LE T+++ LR E+++ K L++E V +
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 571 RQ-----------------RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
RQ R++ + + + +EKEN L ++ ++E +K+++
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 614 KKELEHYKEK---GERAE-ELENELHHLEKENELLQKKITNLKITCEKI-EALEQENSEL 668
+ +++ + K GERA EL +++H L+ E E + + + K+ + + +S+L
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 669 ERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEENLELRRNVE--------SLKCA 716
+ L++ N++ +L LE+E + QLDEE +E ++N+E L +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE-MEAKQNLERHISTLNIQLSDS 1376
Query: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
K+ + LE K++ +K +E L + E +Y L+ RLQ+ L++
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQY---EEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 777 KKIQQLESELQDLEMENQTLQKNL-EELKISSK--------RLEQLEKENK--SLEQETS 825
+ + +LE + + + L EE ISSK E EKE K SL +
Sbjct: 1434 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
+ + K++LE+ NK L+ + E ++ ++ + LEK + L ++ +E +L+E
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM---EEMKTQLEE 1550
Query: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD 945
LE E +AT D K LR ++ + LK Q DL+ + E+ +R LH+
Sbjct: 1551 LEDE-----LQATEDAK----LRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 946 -EQSTDDSRYK-----LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
E +D R + + KLE L K LE++ + +A++ R EE+ ++L+ ++K
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDL-KDLELQAD--SAIKGR-EEAIKQLRKLQAQMKD 1656
Query: 1000 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1059
++ E + +DE I + E++++ +L+++++ L ER
Sbjct: 1657 FQRELEDARASRDE---------IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 1060 AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ-------------TQNAK 1106
EK+ L +L + N LQ + L+ + L+E+ Q TQ A+
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 1107 LQVENSTLNSQSTSLMNQNAQLLIQQSSLE-----NENESVIKEREDLKSLYDSLIKDHE 1161
Q+ N +ST+ N++A+ +++ + E +E E +K + KS +L
Sbjct: 1768 -QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK--FKSTIAALEAKIA 1824
Query: 1162 KLELLHERQASEYE----SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1217
+LE E++A E + SL K LK +E E + E Q K +++ L++
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884
Query: 1218 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1257
L+ +E+ N N + E + N+ + + L
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1924
Score = 180 bits (457), Expect = 1e-44
Identities = 228/953 (23%), Positives = 418/953 (43%), Gaps = 102/953 (10%)
Query: 198 KRLIDER-DEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADA 256
++L++ER + + + E E+ L L + S S K +SRQ L
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE------ 1054
Query: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
K K R+L + + EQ+ D + ++ +++++L + ++E A AR+ DE+
Sbjct: 1055 KLK-RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAALARL-DDEIAQKN 1107
Query: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET-KTMLEDQLEGTRARSD 375
++ +LE +S +E L + + E+ K D LE KT LED L+ T + +
Sbjct: 1108 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167
Query: 376 KLHELEKENLQLKAKL------HDMEME--RDMDRKKIEELMEENMTLEMAQ------KQ 421
+ E+E LK L H+ +++ R + +EEL E+ + A+ KQ
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 422 SMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
+++ E+ L EL + + + E +K L +V EL S+ E L V +L+
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL-QSKCSDGERARAELNDKVHKLQ 1286
Query: 481 TTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
V+SV G + K +K+ K+ LS +++ + + +E + N + L +E+
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 537 QLEKTIET---LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
L+ ++ ++N ER I L + + + + E + K +KE + L
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK-KRFQKEIENLT 1405
Query: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE--LLQKKITNL 651
+ +E ++ K+E K ++++EL+ + +L + L +++ + L ++K +
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
K E+ A E E E E + L + L+ E LE+ N L E +L V
Sbjct: 1466 KYADERDRA-EAEAREKETKALSLARALEEALEAK---EELERTNKMLKAEMEDL---VS 1518
Query: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE----RLEVSYQGLDIENQR 767
S + +L+ + LE++ E++K LE L+ + TE RLEV+ Q L + +R
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 768 -LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE--------QLEKENK 818
LQ E + +K +QL+ +L + E E + +K + K+LE Q + K
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKD---TTLEENNVKIGNLEKENKTLSKEIGI 875
E+ QL K + Q++ + L +D T +EN K +LE + L +++
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 876 YKESCVRLKELEKEN--KELV-----KRATIDIKT-----LVTLREDLVSEKLKTQQMNN 923
E + +LEKE +EL + A D K + L E+L E+ + M++
Sbjct: 1699 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Query: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL-------------LESKLESTLKKSLE 970
+ K T + E++ Q + +R +L +E ++S K ++
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817
Query: 971 IKEEKIAALEARLEESTNYNQQLRQELKTV-KKNYEALKQRQDEERMVQSSPPISGEDN- 1028
E KIA LE ++E+ Q + LK KK E L Q +DE +M + + + N
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877
Query: 1029 ----------KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ 1071
+ E ESQ K++ L E +N + E ALK++L++
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 180 bits (456), Expect = 1e-44
Identities = 234/1095 (21%), Positives = 468/1095 (42%), Gaps = 142/1095 (12%)
Query: 364 EDQLEGTRARSDK----LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
ED+L+ T+ R K L ELE+++ QL + + ++ + + + E E + L A+
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA-AK 916
Query: 420 KQSMDESLH-LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
KQ ++E LH + LE+ + +A +K + ++ +L +LE E + K E
Sbjct: 917 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE----QLEEEEAARQKLQLE 972
Query: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
T ++ +IL M+ +N +LSK+ ++LE I +L + +K+L K K +
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 539 EKTIETL----------RENSERQIKILEQENEHLNQTVSSLRQR--------------- 573
E I L R+ E+ + LE + ++ ++ L+ +
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1092
Query: 574 ------------SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK 621
+ +A +++++E L E + + +K E +KR + +ELE K
Sbjct: 1093 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152
Query: 622 EKGERAEELENELHHLEKENELLQKK---ITNLKITCEKIEALEQENSELERENRKLK-K 677
ELE+ L + EL K+ +T LK +AL++E E + ++++ K
Sbjct: 1153 ------TELEDTLDSTATQQELRAKREQEVTVLK------KALDEETRSHEAQVQEMRQK 1200
Query: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
+ + LT QLE ++ + LD+ L + L + ++ L +E+E +K++L
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL---AGELRVLGQAKQEVEHKKKKL 1257
Query: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN--------------KKIQQLE 783
+ ++ L++ ER L+ + +LQ +E+ K + L
Sbjct: 1258 EAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 784 SELQDLE--MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
S+LQD + ++ +T QK L +S+K L QLE+E SL+ + + + K+ LE+ L
Sbjct: 1315 SQLQDTQELLQEETRQK----LNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 842 RQQAEIKDTTLEENNVKIGNLEKENKTLSKEI----GIYKESCVRLKELEKENKELVKRA 897
Q L++ + LE+ K KEI Y+E +LEK L +
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLL 957
+DLV + +Q+ ++LEK + ++ L E+ S+Y
Sbjct: 1430 -----------DDLVVDLDNQRQLVSNLEKKQRKFDQ--------LLAEEKNISSKYADE 1470
Query: 958 ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1017
+ E+ ++ KE K +L LEE+ ++L + K +K E L +D+ +
Sbjct: 1471 RDRAEAEARE----KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD--VG 1524
Query: 1018 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL-------- 1069
++ + E + +E +L +++D L E L+ QALK Q
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 1070 KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL 1129
+Q E + LQ Q+ + + ++Q KL+ + L Q+ S + + +
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 1130 IQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHK 1189
Q L+ + + +E ED ++ D + ++ E + ++ L + A K
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 1190 NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE----QEKMLLENKNHETVAAEYKKLCG 1245
++E +L + L + L+D ++ L+ +E++ E N E ++ +K
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 1246 ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE----AEFSKLKEQYQQLDI 1301
+ ++L+ ++L E Q + + L +K +++L A SK K L+
Sbjct: 1765 QAEQLS---NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1821
Query: 1302 TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID 1361
+L Q E ++ K + + +++ ++LQ +E + + + + +
Sbjct: 1822 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ----VEDERKMAEQYKEQAEKGNA 1877
Query: 1362 KLNELRRQKEKLEEK 1376
++ +L+RQ E+ EE+
Sbjct: 1878 RVKQLKRQLEEAEEE 1892
Score = 146 bits (369), Expect = 2e-34
Identities = 203/847 (23%), Positives = 361/847 (42%), Gaps = 99/847 (11%)
Query: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
EE++ + L+K E QK LK LEQ++S+L E L++ L + L
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELK-------ELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 688 QLES----LEKENSQLDEENLELRRNVES-------LKCASMKMAQLQLENKELESEKEQ 736
+ E L + +L+E E+ +E L+ KMAQ L+ +E E+E
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 737 LKKGLELLKASFK-KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE--MEN 793
++ L+L K + + K ++LE +D +N +L K + ++I L + L + E +N
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 794 QTLQKNLEELKISSK--RLEQLEKENKSLEQETSQLEKD------------------KKQ 833
T KN E IS RL++ EK + LE+ +LE D K Q
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 834 LEKENKRLRQQ-AEIKDTTLEENNV--KIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
L K+ + L+ A + D ++NN KI LE L +++ E R K EK+
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD--SERAARNKA-EKQK 1141
Query: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
++L + +++ L T ED + Q++ E+ L+K L++E H+ Q
Sbjct: 1142 RDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQ-VQ 1195
Query: 951 DSRYKLLESKLEST--------LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1002
+ R K ++ E T K +L+ ++ + A L Q +QE++ KK
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 1003 NYEALKQR-----QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
EA Q D ER + ++ + +K + E + T L + + + I++ ++ A+
Sbjct: 1256 KLEAQVQELQSKCSDGER---ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
L ++ Q + L++ Q N+ ++ L+ + SLQ+Q L+ STLN Q
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 1118 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1177
+ + +LE + KE E+L Y+ ++KLE R E + L
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 1178 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1237
+ + NLE + R +++QLL ++ +++ E+++ E + ET A
Sbjct: 1433 VVDLDNQRQLVSNLEKKQR----KFDQLLAEE---KNISSKYADERDRAEAEAREKETKA 1485
Query: 1238 AEYKKLCGE----NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1293
+ E + L T L E E L + ++ ++ + + LE + ++K
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 1294 EQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFH 1353
Q ++L+ ++ + K LE + L Q + LQ R EQN E +
Sbjct: 1546 TQLEELE-------DELQATEDAKLRLEVNMQALKGQFER-DLQARD--EQNEEKRRQLQ 1595
Query: 1354 VEQRQYIDKLNELRRQ-------KEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKS 1406
+ +Y +L + R+Q K+KLE + D D + R ++RKL
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE--AIKQLRKLQAQ 1653
Query: 1407 KKDINRE 1413
KD RE
Sbjct: 1654 MKDFQRE 1660
Score = 140 bits (353), Expect = 1e-32
Identities = 199/942 (21%), Positives = 416/942 (44%), Gaps = 97/942 (10%)
Query: 502 RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENE 561
R ++++ E+E+ + K+ Q +N K+L ++ +QL + L+E + + ++ + E
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 562 HLNQTVSSLRQRSQI--SAEARVKDIEKENKILHESIKETSSKLSKIE---FEKRQIKKE 616
+ + ++ +I EAR+++ E + L K+ + ++ +E E+ +++
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 617 LEHYKEKGE-RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
L+ K E + ++LE+E+ ++ +N L K+ K+ E+I L +E E + + L
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE---RKLLEERISDLTTNLAEEEEKAKNL 1025
Query: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE-------------SLKCASMKMAQ 722
K + +++ +LE K+ + +E +L+R +E + A +KM Q
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM-Q 1084
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL--DIENQRLQKTLENSNKKIQ 780
L + +EL++ +L + + KK LE L D++++R + + K+ +
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR--NKAEKQKR 1142
Query: 781 QLESELQDLEME-NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENK 839
L EL+ L+ E TL + ++ +KR +++ K+L++ET E Q+++ +
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE---AQVQEMRQ 1199
Query: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATI 899
+ Q E LE+ NL+K +TL KE L + ++E + K+
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI-GLNKERLLHDEQSTDDSRYKLLE 958
++ L + D E+ + ++N+ + KL +E+E + G+ E + KL +
Sbjct: 1260 QVQELQSKCSD--GERARA-ELNDKVHKLQNEVESVTGMLNE--------AEGKAIKLAK 1308
Query: 959 --SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY-EALKQRQDEER 1015
+ L S L+ + E+ +E+ +L ST +QL +E +++ E ++ +Q+ ER
Sbjct: 1309 DVASLSSQLQDTQELLQEE---TRQKLNVSTKL-RQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 1016 MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1075
+ S+ I D+K + + +T E L+ + + E N T Q E++A +LE
Sbjct: 1365 HI-STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA--AAYDKLEKT 1421
Query: 1076 NNNLQAQI------LALQRQTVS-------------LQEQNTTLQ--TQNAKLQVENSTL 1114
N LQ ++ L QRQ VS +E+N + + + + + E
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 1115 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD-------SLIKDHEKLELLH 1167
+++ SL + L + LE N+ + E EDL S D L K LE
Sbjct: 1482 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1541
Query: 1168 ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED-----LEKMLKVE 1222
E ++ E L + + A LEV + L+ ++ + L+ + + + L++ L
Sbjct: 1542 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 1223 QEKMLLENKNHETVAAEYKKLCG-------ENDRLNHTYSQLLKETEVLQTDHKNLKSLL 1275
+ ++ E K AA KKL G + D + +K+ LQ K+ + L
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1661
Query: 1276 NNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLM 1335
+++ + + A + +++ + L+ +L + + + E L +++ +
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS-S 1720
Query: 1336 LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
L R L+ + K Q ++L E + E + +++
Sbjct: 1721 LSGRNALQ---DEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Score = 134 bits (338), Expect = 6e-31
Identities = 154/767 (20%), Positives = 336/767 (43%), Gaps = 79/767 (10%)
Query: 136 QKKEEFIERI-QGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMA 194
QK + +E + + L+ +A + T +EN + V +++++E K +
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 195 LHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
++ L + + EL+ D +H L + S K + L+ ++A
Sbjct: 1259 AQVQELQSKCSDGERARAELN---DKVHKLQNEVESVTGMLNEAEGKAIK----LAKDVA 1311
Query: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
++++ ++ L+E+T Q L+ +L Q+E E LQ + +E++A
Sbjct: 1312 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-------------LDEEMEA 1358
Query: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
+ + L ++S K++L D + + VE L+E + + L Q E A
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQD---FASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 375 DKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE 434
DKL EK +L+ +L D+ ++ D R+ + L ++ + + + S E +
Sbjct: 1416 DKL---EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472
Query: 435 QISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL 494
+ + E SL + E ++ +LE N+ L +E+L ++ D V N +
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKN---VH 1528
Query: 495 KMEKENQRLSKKVEILENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETLRE-NS 549
++EK + L ++E ++ ++ + + LQ ++ L ++ K Q E+ ++ E N
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 550 ERQIKILEQENEHLNQTVSSLRQRSQISA-----EARVKDIEKENKILHESIKETSSKLS 604
E++ ++ Q +E+ + +QR+ +A E +KD+E + + +E +L
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648
Query: 605 KIEFEKRQIKKELEHY-----------KEKGERAEELENELHHLEKENELLQKKITNLKI 653
K++ + + ++ELE KE ++A+ LE +L L+++ ++ +
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708
Query: 654 TCEKI-----------EALEQENSELERENRKLKKTLDSFK-NLTFQLESLEKENSQLDE 701
E++ AL+ E LE +L++ L+ + N+ + + K Q ++
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 702 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT--------ER 753
+ EL + + QL+ +NKEL S+ +++ + K+ FK T +
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV---KSKFKSTIAALEAKIAQ 1825
Query: 754 LEVSYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMENQTLQKNLEELKISSKR 809
LE + E Q K+L+ +KK++ Q+E E + E + +K +K ++
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 810 LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENN 856
LE+ E+E++ + +L+++ + + N+ + ++ + L N
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1932
Score = 130 bits (327), Expect = 1e-29
Identities = 180/799 (22%), Positives = 350/799 (43%), Gaps = 117/799 (14%)
Query: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK----EQLKKGLELL 744
L + ++ ++ + EL++ E + A ++ +L+ ++ +L EK EQL+ EL
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
+ + RL Q L+ ++ LE + QQL++E + + + L++ LEE +
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 805 ISSKRLEQLEK-----ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
+ ++L QLEK + K LE E ++ +L KE K L ++ T L E K
Sbjct: 964 AARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK-------------------RATI- 899
NL K +K + E VRLK+ EK +EL K +A I
Sbjct: 1023 KNL---TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 900 DIKTLVTLREDLVSEKL-----KTQQMNNDLEKLTHELE------KIGLNKERLLH---D 945
++K + +E+ + L + Q NN L+K+ ELE + L+ ER +
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEGHISDLQEDLDSERAARNKAE 1138
Query: 946 EQSTD-DSRYKLLESKLESTL-----KKSLEIK-EEKIAALEARLEESTNYNQQLRQELK 998
+Q D + L+++LE TL ++ L K E+++ L+ L+E T ++ QE++
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 999 TVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
+K+ +A+++ ++ E+ ++ + E+E+ + EL + EVE
Sbjct: 1199 --QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
L+A+ Q L+++ E L ++ LQ + S+ + + KL + ++L+SQ
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 1118 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1177
Q+ Q L+Q+ + + N S KL L E + S + L
Sbjct: 1317 L-----QDTQELLQEETRQKLNVST-------------------KLRQLEEERNSLQDQL 1352
Query: 1178 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1237
+ A +NLE R + QL K +L+D ++ +E K E +
Sbjct: 1353 DEE----MEAKQNLE---RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 1238 AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE---AEFSKLKE 1294
+Y++ D+L T ++L +E + L D N + L++N + +Q + + AE +
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 1295 QY-----------QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1343
+Y ++ + + L E + K LE N+ L +++ L+ +
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-- 1523
Query: 1344 QNMESKDLFHVE--QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK-- 1399
K++ +E +R ++ E++ Q E+LE D+ + + + R N LK
Sbjct: 1524 ----GKNVHELEKSKRALETQMEEMKTQLEELE----DELQATEDAKLRLEVNMQALKGQ 1575
Query: 1400 MRKLIKSKKDINRERQKSL 1418
+ ++++ + N E+++ L
Sbjct: 1576 FERDLQARDEQNEEKRRQL 1594
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 197 bits (502), Expect = 6e-50
Identities = 263/1120 (23%), Positives = 502/1120 (44%), Gaps = 162/1120 (14%)
Query: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
++ R +E++ K ++L K+ ++ E ELK L+Q++ L + + +++L A E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQEQLQAETEL 909
Query: 319 AVRVDKLESEVSRYKERLHDI-EFYKARVEELKEDNQVL-LETKTM------LEDQLEGT 370
+++ ++ K+ L +I +AR+EE ++ Q L E K M LE+QLE
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 371 RARSDKLHELEKENLQLKAK--------LHDMEMERDMDRKKIEE--------LMEE--- 411
A KL +LEK + K K + D + +RK +EE L EE
Sbjct: 970 EAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 412 --NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG-----HEVNELTSSRLLK 464
N+T + +SM L + + E+ SR EL + +K G HE +++ +
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
L+M+ L K EEL+ + ++ ++ K+ + L + L+ ++ E+ +
Sbjct: 1088 LKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 525 QNLSKDLMKE----KAQLEKTIET------LRENSERQI----KILEQENEHLNQTVSSL 570
+ +DL +E K +LE T+++ LR E+++ K L++E V +
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 571 RQ-----------------RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
RQ R++ + + + +EKEN L ++ ++E +K+++
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 614 KKELEHYKEK---GERAE-ELENELHHLEKENELLQKKITNLKITCEKI-EALEQENSEL 668
+ +++ + K GERA EL +++H L+ E E + + + K+ + + +S+L
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 669 ERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEENLELRRNVE--------SLKCA 716
+ L++ N++ +L LE+E + QLDEE +E ++N+E L +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE-MEAKQNLERHISTLNIQLSDS 1383
Query: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
K+ + LE K++ +K +E L + E +Y L+ RLQ+ L++
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQY---EEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 777 KKIQQLESELQDLEMENQTLQKNL-EELKISSK--------RLEQLEKENK--SLEQETS 825
+ + +LE + + + L EE ISSK E EKE K SL +
Sbjct: 1441 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1500
Query: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
+ + K++LE+ NK L+ + E ++ ++ + LEK + L ++ +E +L+E
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM---EEMKTQLEE 1557
Query: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD 945
LE E +AT D K LR ++ + LK Q DL+ + E+ +R LH+
Sbjct: 1558 LEDE-----LQATEDAK----LRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 946 -EQSTDDSRYK-----LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
E +D R + + KLE L K LE++ + +A++ R EE+ ++L+ ++K
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDL-KDLELQAD--SAIKGR-EEAIKQLRKLQAQMKD 1663
Query: 1000 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1059
++ E + +DE I + E++++ +L+++++ L ER
Sbjct: 1664 FQRELEDARASRDE---------IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 1060 AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ-------------TQNAK 1106
EK+ L +L + N LQ + L+ + L+E+ Q TQ A+
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 1107 LQVENSTLNSQSTSLMNQNAQLLIQQSSLE-----NENESVIKEREDLKSLYDSLIKDHE 1161
Q+ N +ST+ N++A+ +++ + E +E E +K + KS +L
Sbjct: 1775 -QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK--FKSTIAALEAKIA 1831
Query: 1162 KLELLHERQASEYE----SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1217
+LE E++A E + SL K LK +E E + E Q K +++ L++
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891
Query: 1218 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1257
L+ +E+ N N + E + N+ + + L
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1931
Score = 180 bits (457), Expect = 1e-44
Identities = 228/953 (23%), Positives = 418/953 (43%), Gaps = 102/953 (10%)
Query: 198 KRLIDER-DEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADA 256
++L++ER + + + E E+ L L + S S K +SRQ L
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE------ 1061
Query: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
K K R+L + + EQ+ D + ++ +++++L + ++E A AR+ DE+
Sbjct: 1062 KLK-RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAALARL-DDEIAQKN 1114
Query: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET-KTMLEDQLEGTRARSD 375
++ +LE +S +E L + + E+ K D LE KT LED L+ T + +
Sbjct: 1115 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174
Query: 376 KLHELEKENLQLKAKL------HDMEME--RDMDRKKIEELMEENMTLEMAQ------KQ 421
+ E+E LK L H+ +++ R + +EEL E+ + A+ KQ
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 422 SMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
+++ E+ L EL + + + E +K L +V EL S+ E L V +L+
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL-QSKCSDGERARAELNDKVHKLQ 1293
Query: 481 TTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
V+SV G + K +K+ K+ LS +++ + + +E + N + L +E+
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 537 QLEKTIET---LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
L+ ++ ++N ER I L + + + + E + K +KE + L
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK-KRFQKEIENLT 1412
Query: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE--LLQKKITNL 651
+ +E ++ K+E K ++++EL+ + +L + L +++ + L ++K +
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
K E+ A E E E E + L + L+ E LE+ N L E +L V
Sbjct: 1473 KYADERDRA-EAEAREKETKALSLARALEEALEAK---EELERTNKMLKAEMEDL---VS 1525
Query: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE----RLEVSYQGLDIENQR 767
S + +L+ + LE++ E++K LE L+ + TE RLEV+ Q L + +R
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 768 -LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE--------QLEKENK 818
LQ E + +K +QL+ +L + E E + +K + K+LE Q + K
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKD---TTLEENNVKIGNLEKENKTLSKEIGI 875
E+ QL K + Q++ + L +D T +EN K +LE + L +++
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 876 YKESCVRLKELEKEN--KELV-----KRATIDIKT-----LVTLREDLVSEKLKTQQMNN 923
E + +LEKE +EL + A D K + L E+L E+ + M++
Sbjct: 1706 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Query: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL-------------LESKLESTLKKSLE 970
+ K T + E++ Q + +R +L +E ++S K ++
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824
Query: 971 IKEEKIAALEARLEESTNYNQQLRQELKTV-KKNYEALKQRQDEERMVQSSPPISGEDN- 1028
E KIA LE ++E+ Q + LK KK E L Q +DE +M + + + N
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884
Query: 1029 ----------KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ 1071
+ E ESQ K++ L E +N + E ALK++L++
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 180 bits (456), Expect = 1e-44
Identities = 234/1095 (21%), Positives = 468/1095 (42%), Gaps = 142/1095 (12%)
Query: 364 EDQLEGTRARSDK----LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
ED+L+ T+ R K L ELE+++ QL + + ++ + + + E E + L A+
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA-AK 923
Query: 420 KQSMDESLH-LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
KQ ++E LH + LE+ + +A +K + ++ +L +LE E + K E
Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE----QLEEEEAARQKLQLE 979
Query: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
T ++ +IL M+ +N +LSK+ ++LE I +L + +K+L K K +
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 539 EKTIETL----------RENSERQIKILEQENEHLNQTVSSLRQR--------------- 573
E I L R+ E+ + LE + ++ ++ L+ +
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1099
Query: 574 ------------SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK 621
+ +A +++++E L E + + +K E +KR + +ELE K
Sbjct: 1100 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159
Query: 622 EKGERAEELENELHHLEKENELLQKK---ITNLKITCEKIEALEQENSELERENRKLK-K 677
ELE+ L + EL K+ +T LK +AL++E E + ++++ K
Sbjct: 1160 ------TELEDTLDSTATQQELRAKREQEVTVLK------KALDEETRSHEAQVQEMRQK 1207
Query: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
+ + LT QLE ++ + LD+ L + L + ++ L +E+E +K++L
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL---AGELRVLGQAKQEVEHKKKKL 1264
Query: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN--------------KKIQQLE 783
+ ++ L++ ER L+ + +LQ +E+ K + L
Sbjct: 1265 EAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 784 SELQDLE--MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
S+LQD + ++ +T QK L +S+K L QLE+E SL+ + + + K+ LE+ L
Sbjct: 1322 SQLQDTQELLQEETRQK----LNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 842 RQQAEIKDTTLEENNVKIGNLEKENKTLSKEI----GIYKESCVRLKELEKENKELVKRA 897
Q L++ + LE+ K KEI Y+E +LEK L +
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLL 957
+DLV + +Q+ ++LEK + ++ L E+ S+Y
Sbjct: 1437 -----------DDLVVDLDNQRQLVSNLEKKQRKFDQ--------LLAEEKNISSKYADE 1477
Query: 958 ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV 1017
+ E+ ++ KE K +L LEE+ ++L + K +K E L +D+ +
Sbjct: 1478 RDRAEAEARE----KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD--VG 1531
Query: 1018 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL-------- 1069
++ + E + +E +L +++D L E L+ QALK Q
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 1070 KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLL 1129
+Q E + LQ Q+ + + ++Q KL+ + L Q+ S + + +
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 1130 IQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHK 1189
Q L+ + + +E ED ++ D + ++ E + ++ L + A K
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 1190 NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE----QEKMLLENKNHETVAAEYKKLCG 1245
++E +L + L + L+D ++ L+ +E++ E N E ++ +K
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 1246 ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE----AEFSKLKEQYQQLDI 1301
+ ++L+ ++L E Q + + L +K +++L A SK K L+
Sbjct: 1772 QAEQLS---NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEA 1828
Query: 1302 TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID 1361
+L Q E ++ K + + +++ ++LQ +E + + + + +
Sbjct: 1829 KIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ----VEDERKMAEQYKEQAEKGNA 1884
Query: 1362 KLNELRRQKEKLEEK 1376
++ +L+RQ E+ EE+
Sbjct: 1885 RVKQLKRQLEEAEEE 1899
Score = 146 bits (369), Expect = 2e-34
Identities = 203/847 (23%), Positives = 361/847 (42%), Gaps = 99/847 (11%)
Query: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
EE++ + L+K E QK LK LEQ++S+L E L++ L + L
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELK-------ELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 688 QLES----LEKENSQLDEENLELRRNVES-------LKCASMKMAQLQLENKELESEKEQ 736
+ E L + +L+E E+ +E L+ KMAQ L+ +E E+E
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 737 LKKGLELLKASFK-KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE--MEN 793
++ L+L K + + K ++LE +D +N +L K + ++I L + L + E +N
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 794 QTLQKNLEELKISSK--RLEQLEKENKSLEQETSQLEKD------------------KKQ 833
T KN E IS RL++ EK + LE+ +LE D K Q
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 834 LEKENKRLRQQ-AEIKDTTLEENNV--KIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
L K+ + L+ A + D ++NN KI LE L +++ E R K EK+
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD--SERAARNKA-EKQK 1148
Query: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
++L + +++ L T ED + Q++ E+ L+K L++E H+ Q
Sbjct: 1149 RDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQ-VQ 1202
Query: 951 DSRYKLLESKLEST--------LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1002
+ R K ++ E T K +L+ ++ + A L Q +QE++ KK
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 1003 NYEALKQR-----QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
EA Q D ER + ++ + +K + E + T L + + + I++ ++ A+
Sbjct: 1263 KLEAQVQELQSKCSDGER---ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
L ++ Q + L++ Q N+ ++ L+ + SLQ+Q L+ STLN Q
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 1118 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1177
+ + +LE + KE E+L Y+ ++KLE R E + L
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 1178 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1237
+ + NLE + R +++QLL ++ +++ E+++ E + ET A
Sbjct: 1440 VVDLDNQRQLVSNLEKKQR----KFDQLLAEE---KNISSKYADERDRAEAEAREKETKA 1492
Query: 1238 AEYKKLCGE----NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1293
+ E + L T L E E L + ++ ++ + + LE + ++K
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 1294 EQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFH 1353
Q ++L+ ++ + K LE + L Q + LQ R EQN E +
Sbjct: 1553 TQLEELE-------DELQATEDAKLRLEVNMQALKGQFER-DLQARD--EQNEEKRRQLQ 1602
Query: 1354 VEQRQYIDKLNELRRQ-------KEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKS 1406
+ +Y +L + R+Q K+KLE + D D + R ++RKL
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE--AIKQLRKLQAQ 1660
Query: 1407 KKDINRE 1413
KD RE
Sbjct: 1661 MKDFQRE 1667
Score = 140 bits (353), Expect = 1e-32
Identities = 199/942 (21%), Positives = 416/942 (44%), Gaps = 97/942 (10%)
Query: 502 RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENE 561
R ++++ E+E+ + K+ Q +N K+L ++ +QL + L+E + + ++ + E
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 562 HLNQTVSSLRQRSQI--SAEARVKDIEKENKILHESIKETSSKLSKIE---FEKRQIKKE 616
+ + ++ +I EAR+++ E + L K+ + ++ +E E+ +++
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 617 LEHYKEKGE-RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
L+ K E + ++LE+E+ ++ +N L K+ K+ E+I L +E E + + L
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE---RKLLEERISDLTTNLAEEEEKAKNL 1032
Query: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE-------------SLKCASMKMAQ 722
K + +++ +LE K+ + +E +L+R +E + A +KM Q
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM-Q 1091
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL--DIENQRLQKTLENSNKKIQ 780
L + +EL++ +L + + KK LE L D++++R + + K+ +
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR--NKAEKQKR 1149
Query: 781 QLESELQDLEME-NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENK 839
L EL+ L+ E TL + ++ +KR +++ K+L++ET E Q+++ +
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE---AQVQEMRQ 1206
Query: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATI 899
+ Q E LE+ NL+K +TL KE L + ++E + K+
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI-GLNKERLLHDEQSTDDSRYKLLE 958
++ L + D E+ + ++N+ + KL +E+E + G+ E + KL +
Sbjct: 1267 QVQELQSKCSD--GERARA-ELNDKVHKLQNEVESVTGMLNE--------AEGKAIKLAK 1315
Query: 959 --SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY-EALKQRQDEER 1015
+ L S L+ + E+ +E+ +L ST +QL +E +++ E ++ +Q+ ER
Sbjct: 1316 DVASLSSQLQDTQELLQEE---TRQKLNVSTKL-RQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 1016 MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1075
+ S+ I D+K + + +T E L+ + + E N T Q E++A +LE
Sbjct: 1372 HI-STLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA--AAYDKLEKT 1428
Query: 1076 NNNLQAQI------LALQRQTVS-------------LQEQNTTLQ--TQNAKLQVENSTL 1114
N LQ ++ L QRQ VS +E+N + + + + + E
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 1115 NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD-------SLIKDHEKLELLH 1167
+++ SL + L + LE N+ + E EDL S D L K LE
Sbjct: 1489 ETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM 1548
Query: 1168 ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED-----LEKMLKVE 1222
E ++ E L + + A LEV + L+ ++ + L+ + + + L++ L
Sbjct: 1549 EEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 1223 QEKMLLENKNHETVAAEYKKLCG-------ENDRLNHTYSQLLKETEVLQTDHKNLKSLL 1275
+ ++ E K AA KKL G + D + +K+ LQ K+ + L
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQREL 1668
Query: 1276 NNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLM 1335
+++ + + A + +++ + L+ +L + + + E L +++ +
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS-S 1727
Query: 1336 LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
L R L+ + K Q ++L E + E + +++
Sbjct: 1728 LSGRNALQ---DEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Score = 134 bits (338), Expect = 6e-31
Identities = 154/767 (20%), Positives = 336/767 (43%), Gaps = 79/767 (10%)
Query: 136 QKKEEFIERI-QGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMA 194
QK + +E + + L+ +A + T +EN + V +++++E K +
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 195 LHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
++ L + + EL+ D +H L + S K + L+ ++A
Sbjct: 1266 AQVQELQSKCSDGERARAELN---DKVHKLQNEVESVTGMLNEAEGKAIK----LAKDVA 1318
Query: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
++++ ++ L+E+T Q L+ +L Q+E E LQ + +E++A
Sbjct: 1319 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-------------LDEEMEA 1365
Query: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
+ + L ++S K++L D + + VE L+E + + L Q E A
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQD---FASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 375 DKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE 434
DKL EK +L+ +L D+ ++ D R+ + L ++ + + + S E +
Sbjct: 1423 DKL---EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479
Query: 435 QISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL 494
+ + E SL + E ++ +LE N+ L +E+L ++ D V N +
Sbjct: 1480 RAEAEAREKETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKN---VH 1535
Query: 495 KMEKENQRLSKKVEILENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETLRE-NS 549
++EK + L ++E ++ ++ + + LQ ++ L ++ K Q E+ ++ E N
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 550 ERQIKILEQENEHLNQTVSSLRQRSQISA-----EARVKDIEKENKILHESIKETSSKLS 604
E++ ++ Q +E+ + +QR+ +A E +KD+E + + +E +L
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655
Query: 605 KIEFEKRQIKKELEHY-----------KEKGERAEELENELHHLEKENELLQKKITNLKI 653
K++ + + ++ELE KE ++A+ LE +L L+++ ++ +
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715
Query: 654 TCEKI-----------EALEQENSELERENRKLKKTLDSFK-NLTFQLESLEKENSQLDE 701
E++ AL+ E LE +L++ L+ + N+ + + K Q ++
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 702 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT--------ER 753
+ EL + + QL+ +NKEL S+ +++ + K+ FK T +
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV---KSKFKSTIAALEAKIAQ 1832
Query: 754 LEVSYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMENQTLQKNLEELKISSKR 809
LE + E Q K+L+ +KK++ Q+E E + E + +K +K ++
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 810 LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENN 856
LE+ E+E++ + +L+++ + + N+ + ++ + L N
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939
Score = 130 bits (327), Expect = 1e-29
Identities = 180/799 (22%), Positives = 350/799 (43%), Gaps = 117/799 (14%)
Query: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK----EQLKKGLELL 744
L + ++ ++ + EL++ E + A ++ +L+ ++ +L EK EQL+ EL
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
+ + RL Q L+ ++ LE + QQL++E + + + L++ LEE +
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 805 ISSKRLEQLEK-----ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
+ ++L QLEK + K LE E ++ +L KE K L ++ T L E K
Sbjct: 971 AARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK-------------------RATI- 899
NL K +K + E VRLK+ EK +EL K +A I
Sbjct: 1030 KNL---TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 900 DIKTLVTLREDLVSEKL-----KTQQMNNDLEKLTHELE------KIGLNKERLLH---D 945
++K + +E+ + L + Q NN L+K+ ELE + L+ ER +
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEGHISDLQEDLDSERAARNKAE 1145
Query: 946 EQSTD-DSRYKLLESKLESTL-----KKSLEIK-EEKIAALEARLEESTNYNQQLRQELK 998
+Q D + L+++LE TL ++ L K E+++ L+ L+E T ++ QE++
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Query: 999 TVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
+K+ +A+++ ++ E+ ++ + E+E+ + EL + EVE
Sbjct: 1206 --QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
L+A+ Q L+++ E L ++ LQ + S+ + + KL + ++L+SQ
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 1118 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1177
Q+ Q L+Q+ + + N S KL L E + S + L
Sbjct: 1324 L-----QDTQELLQEETRQKLNVST-------------------KLRQLEEERNSLQDQL 1359
Query: 1178 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1237
+ A +NLE R + QL K +L+D ++ +E K E +
Sbjct: 1360 DEE----MEAKQNLE---RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 1238 AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE---AEFSKLKE 1294
+Y++ D+L T ++L +E + L D N + L++N + +Q + + AE +
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 1295 QY-----------QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1343
+Y ++ + + L E + K LE N+ L +++ L+ +
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-- 1530
Query: 1344 QNMESKDLFHVE--QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK-- 1399
K++ +E +R ++ E++ Q E+LE D+ + + + R N LK
Sbjct: 1531 ----GKNVHELEKSKRALETQMEEMKTQLEELE----DELQATEDAKLRLEVNMQALKGQ 1582
Query: 1400 MRKLIKSKKDINRERQKSL 1418
+ ++++ + N E+++ L
Sbjct: 1583 FERDLQARDEQNEEKRRQL 1601
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 194 bits (492), Expect = 9e-49
Identities = 298/1344 (22%), Positives = 578/1344 (43%), Gaps = 192/1344 (14%)
Query: 58 KLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQG 117
KL+S+ ++ HN V+ +K +Q+ + +L F
Sbjct: 403 KLKSELAGLNKQFCYTVEQHNRE--VQSLKEQHQKEISEL------------NETFLSDS 448
Query: 118 TEEVKKLLLLLLGCAVQC----QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDL 173
+E L+ + G QC Q+K+E I L++++ + +Q
Sbjct: 449 EKEKLTLMFEIQGLKEQCENLQQEKQEAI-----LNYESLREIMEILQTELGESAGKISQ 503
Query: 174 QWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGL----HFLPHASS 229
++ + D+ L + L+ E+D ET+ L E + L +P +
Sbjct: 504 EFESMKQQQASDVHELQQK----LRTAFTEKDALLETVNRLQGENEKLLSQQELVPELEN 559
Query: 230 SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELK 289
+ ++ G+ Q ++ L + + KI L +E ++ +L + +E++ + +
Sbjct: 560 TIKNLQEKNGVYLLSLSQRDTM-LKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCE 618
Query: 290 RLQQENMNLLSDARSARMYRDELD------------ALREKAVRVDKLESEVSRYKERLH 337
R ++ + L Y EL+ L+EK KLE + + K
Sbjct: 619 REERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSE 678
Query: 338 DIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEME 397
D E A V+ L E+N L K L LE + +KE++ LK + +E
Sbjct: 679 DKEVLSAEVKSLYEENNKLSSEKKQLSRDLE--------VFLSQKEDVILKEHITQLE-- 728
Query: 398 RDMDRKKIEELMEE----NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHE 453
KK++ ++EE N LE Q Q + L L+++ SE+SE ++
Sbjct: 729 -----KKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMG--SEVSEDSEEKDVVN 781
Query: 454 VNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE 513
V + L K+ E +L +E K+L++EKE ++ L+ E
Sbjct: 782 VLQAVGESLAKINEEKCNLAFQRDE-------------KVLELEKE-------IKCLQEE 821
Query: 514 IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER-QIKILEQENEHLNQTVSSLRQ 572
V + + L++ L +D +EK L K +E ++ E Q +LE +N + +
Sbjct: 822 SVVQCEELKS---LLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNAN---------E 869
Query: 573 RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
++++ + + +E+ ++ +S E ++ K ++ + K L KE +R EL
Sbjct: 870 KTRLENQNLLIQVEEVSQTCSKS--EIHNEKEKCFIKEHENLKPLLEQKELRDRRAELIL 927
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK-------KTLDSFKNL 685
L K + ++++K EKIE LE+E E E + K+K K LDS +
Sbjct: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
Query: 686 TF----QLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
T +LESL E QL +L + ES K + + + ++++L+ EKE+
Sbjct: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNL---LLEYEKQSEQLDVEKERANNFE 1044
Query: 742 ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
++ ++ + + ++ +N+ L +E + LE ++ +++ + K LE
Sbjct: 1045 HRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELE 1104
Query: 802 ELKISSK-RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ-QAEIKDTTLEENNVKI 859
K+ + ++++ LE+ QL+K+KKQL+K + L + + + TTL N++I
Sbjct: 1105 AEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLM--NMEI 1162
Query: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQ 919
+ E+ K L++++ ++++LE+E K I + TL+E++ S + Q
Sbjct: 1163 ADYERLMKELNQKLTNKNN---KIEDLEQEIK-------IQKQKQETLQEEITSLQSSVQ 1212
Query: 920 QMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAAL 979
Q K+ L K K+ L +Q+ D L+++LK LE ++++
Sbjct: 1213 QYEEKNTKIKQLLVK---TKKELADSKQAETDHLI------LQASLKGELEASQQQVEVY 1263
Query: 980 EARLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETT 1038
+ +L E T+ ++ + LKT + ++ L Q +Q + K E+ + +
Sbjct: 1264 KIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAA----KAEQATVTSE 1319
Query: 1039 RELLKVK-DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1097
E KV+ +++ ++N + QAE + K + + LE + + + + LQ+
Sbjct: 1320 FESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLE----------MLIDQLKIKLQDSQ 1369
Query: 1098 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1157
LQ ++LQ TL S+ +L+ ++ ++L E+V KE E L+ S+
Sbjct: 1370 NNLQINVSELQ----TLQSEHDTLLERHNKML---------QETVSKEAE-LREKLCSIQ 1415
Query: 1158 KDHEKLELLHERQASEYESLISKHGTLKSAHKN----LEVEHRD-LEDRYNQLLKQKGQL 1212
++ ++ H + S+ L S++ L+++ ++ L+ EHR +E QL K + QL
Sbjct: 1416 SENMMMKSEHTQTVSQ---LTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQL 1472
Query: 1213 EDLEK-------MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ 1265
L+ + + K L E +N + + + E T +
Sbjct: 1473 FQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDT--ESVSSAS 1530
Query: 1266 TDHKNLKSLLNN--SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE 1323
T ++L+ LLN+ +KLE AEF+K +E Q+L T+ ++ L+ L E
Sbjct: 1531 TYTQSLEQLLNSPETKLEPPLWHAEFTK-EELVQKLSSTTKSADH----LNGLLRETEAT 1585
Query: 1324 NRHLLDQIQTLMLQNRTLLEQNME 1347
N L++QI+ L + R LE+N E
Sbjct: 1586 NAILMEQIKLLKSEIRR-LERNQE 1608
Score = 179 bits (455), Expect = 2e-44
Identities = 271/1223 (22%), Positives = 538/1223 (43%), Gaps = 197/1223 (16%)
Query: 196 HLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGS-PGMKRTESRQHLSVELA 254
H + + +++H + I EL+E FL + + G+K E ++L E
Sbjct: 422 HNREVQSLKEQHQKEISELNET-----FLSDSEKEKLTLMFEIQGLK--EQCENLQQEKQ 474
Query: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
+A LR+ +E +L + ++ Q +K+ Q +++ L + R E DA
Sbjct: 475 EAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ--QKLRTAFTEKDA 532
Query: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL----ETKTMLEDQLEGT 370
L E R+ ++ +E + ++E ++ L+E N V L + TML++ LEG
Sbjct: 533 LLETVNRLQGENEKLLSQQELVPELE---NTIKNLQEKNGVYLLSLSQRDTMLKE-LEG- 587
Query: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
K++ L +E KL + E D KK E EE + LE+ +K +++++
Sbjct: 588 -----KINSLTEEKDDFINKLKNSHEEMDNFHKKCER--EERLILELGKK--VEQTIQYN 638
Query: 431 WELEQISRTSELSEAPQKSLGHEVNELTSS---RLLKLEMENQSLTKTVEELRTTVDSVE 487
ELEQ +VNELT L + + +Q L K + +++ + E
Sbjct: 639 SELEQ-----------------KVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKE 681
Query: 488 GNASKILKMEKENQRLSKKVEILENEI---VQEKQSLQNCQNLSKDLMKEK-AQLEKTIE 543
++++ + +EN +LS + + L ++ + +K+ + ++KE QLEK ++
Sbjct: 682 VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDV---------ILKEHITQLEKKLQ 732
Query: 544 TLRENSERQIKILEQENEHL----NQTVSSLRQR-SQISAEARVKDIEKENKILHESIKE 598
+ E + K+LE E Q L++ S++S ++ KD+ + + ES+ +
Sbjct: 733 LMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAK 792
Query: 599 TSSKLSKIEFEKRQIKKELEH-----YKEKGERAEELENELHHLEKENELLQKKITNLKI 653
+ + + F++ + ELE +E + EEL++ L E+E LL+K++ +I
Sbjct: 793 INEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE--EI 850
Query: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
EK EAL+ + E++ N K + L++ +NL Q+E + + S+ + N E
Sbjct: 851 QSEK-EALQSDLLEMKNANEKTR--LEN-QNLLIQVEEVSQTCSKSEIHN-------EKE 899
Query: 714 KCASMKMAQLQ--LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
KC + L+ LE KEL + +L LLK S K+ ++N L
Sbjct: 900 KCFIKEHENLKPLLEQKELRDRRAELI----LLKDSLAKSP---------SVKNDPLSS- 945
Query: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKI----SSKRLEQLEKENKSLEQETSQL 827
+++LE ++++LE E + ++ + ++K+ + K L+ KE +++++E L
Sbjct: 946 -------VKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESL 998
Query: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
+K QL + L Q AE NL E + S+++ + KE +
Sbjct: 999 RSEKDQLSASMRDLIQGAE-----------SYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Query: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947
++ ++ +T+ +T+ + EDL++ +++T Q N L E++ + + + + + D++
Sbjct: 1048 EDLTRQLRNSTLQCETINSDNEDLLA-RIETLQSNAKLL----EVQILEVQRAKAMVDKE 1102
Query: 948 STDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL 1007
+ K + K +T LE L+ +L++ Q+ QEL+ VKK+
Sbjct: 1103 LEAEKLQKEQKIKEHATTVNELE-------ELQVQLQKEKKQLQKTMQELELVKKD---- 1151
Query: 1008 KQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKT 1067
Q + ++ E +ER +E ++L +++ ++E Q +K
Sbjct: 1152 ---------AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE----------QEIKI 1192
Query: 1068 QLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1127
Q ++ ET LQ +I +LQ +E+NT ++ K + E + T + A
Sbjct: 1193 QKQKQET----LQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQAS 1248
Query: 1128 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELL---HERQASEYESLIS----- 1179
L + LE + V + L + K HE L+ H+R S Y+ ++
Sbjct: 1249 L---KGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEE 1305
Query: 1180 ------KHGTLKSAHKNLEVE-HRDLEDRYNQLLKQ------KGQLEDLEKMLKVEQEKM 1226
+ T+ S ++ +V H L+ + N+ + Q K + E LE ++ + K+
Sbjct: 1306 CRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKL 1365
Query: 1227 LLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1286
N + +E + L E+D L ++++L+ET + + L+ L + + E ++
Sbjct: 1366 QDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAE---LREKLCSIQSENMMMK 1422
Query: 1287 AEFSKLKEQY-QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQI-QTLMLQNRTLLEQ 1344
+E ++ Q Q ++ +Q +L+EE+R ++ + Q L L +
Sbjct: 1423 SEHTQTVSQLTSQNEVLRNSFRDQVR-------HLQEEHRKTVETLQQQLSKMEAQLFQL 1475
Query: 1345 NMESKDLFHVEQRQYIDKLNELR 1367
E V +Q + L E R
Sbjct: 1476 KNEPTTRSPVSSQQSLKNLRERR 1498
Score = 171 bits (432), Expect = 8e-42
Identities = 277/1182 (23%), Positives = 511/1182 (43%), Gaps = 164/1182 (13%)
Query: 278 KQELEQMEIE-LKRLQQENMNLLSDARS-ARMYRDELDALREKAVRVDKLESEVSRYKER 335
K +LE + E L + ++ M L+ A+S E++ LR K V + + ER
Sbjct: 19 KSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPV-TEGTGDIIKALTER 77
Query: 336 LHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKL 391
L + KA E+ LK++N ++ K +ED + D ELE+ ++ ++
Sbjct: 78 LDALLLEKAETEQQCLSLKKEN---IKMKQEVEDSVT---KMGDAHKELEQSHINYVKEI 131
Query: 392 HDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451
+++ E R K E + L+ +++M+ L L +L + SE K L
Sbjct: 132 ENLKNELMAVRSKYSE---DKANLQKQLEEAMNTQLELSEQL----KFQNNSEDNVKKLQ 184
Query: 452 HEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
E+ ++ ++ + L T +E + TV ++ +E +Q K + L+
Sbjct: 185 EEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNI------IEANSQHYQKNINSLQ 238
Query: 512 NEIVQEKQSLQN------CQNLSKDLMKEKAQLEKTIETLREN-------SERQI-KILE 557
E++Q K Q CQ + + +A++ K E L+EN SE+ I K E
Sbjct: 239 EELLQLKAIHQEEVKELMCQ-IEASAKEHEAEINKLNE-LKENLVKQCEASEKNIQKKYE 296
Query: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE- 616
E E+L + S+ Q +QI + ++ E ++++E +K L ++E + +K E
Sbjct: 297 CELENLRKATSNANQDNQICSILLQENTFVE-QVVNEKVKHLEDTLKELESQHSILKDEV 355
Query: 617 --LEHYKEKGER-AEELENELHHLEKENELLQKKITNLKITCEKIEA-LEQENSELEREN 672
+ + K K E A+ +++E H E E L+ KI L + E+ +E+ SEL N
Sbjct: 356 TYMNNLKLKLEMDAQHIKDEFFH---EREDLEFKINELLLAKEEQGCVIEKLKSELAGLN 412
Query: 673 RKLKKTLDSFKNLTFQL-ESLEKENSQLDE--------ENLELRRNVESLKCASMKMAQL 723
++ T++ L E +KE S+L+E E L L ++ LK + L
Sbjct: 413 KQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLK---EQCENL 469
Query: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Q E +E E L++ +E+L+ + K + QQ
Sbjct: 470 QQEKQEAILNYESLREIMEILQTEL----------------GESAGKISQEFESMKQQQA 513
Query: 784 SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843
S++ +L+ + +T + L + RL+ ++ S ++ +LE K L+++N
Sbjct: 514 SDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLL 573
Query: 844 QAEIKDTTLEENNVKIGNLEKEN-------KTLSKEIGIYKESCVRLKELEKENKELVKR 896
+DT L+E KI +L +E K +E+ + + C R + L E + V++
Sbjct: 574 SLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
Query: 897 A---TIDIKTLVTLREDLVSEKLKTQQMNND-LEKLTHELEKIGLNKERL------LHDE 946
+++ V + E LK + N+ LEKL +++ + +KE L L++E
Sbjct: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEE 693
Query: 947 QSTDDSRYKLLESKLESTL-KKSLEIKEEKIAALEARL----EESTNYNQQLR----QEL 997
+ S K L LE L +K I +E I LE +L EE N N+ L Q+L
Sbjct: 694 NNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKL 753
Query: 998 KTVKKNYEALKQ------RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1051
+ Y LK+ EE+ V + GE + ++E + ++++E+
Sbjct: 754 FVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGE--SLAKINEEKCNLAFQRDEKVLEL 811
Query: 1052 ERNNATLQAEK----QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKL 1107
E+ LQ E + LK+ L+ E + L+ ++ +Q + +LQ ++ N K
Sbjct: 812 EKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKT 871
Query: 1108 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENES-VIKEREDLKSLYDSLIKDHEKLELL 1166
++EN Q+ + + +S + NE E IKE E+LK L + + EL+
Sbjct: 872 RLEN-----QNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELI 926
Query: 1167 -----HERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1221
+ S +S L+ +NLE E ++ E++ N++ K++ V
Sbjct: 927 LLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKI-----------KLVAV 975
Query: 1222 EQEKML-LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1280
+ +K L K +TV E + L E D+L+ + L++ E + K+LL +
Sbjct: 976 KAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAE-------SYKNLLLEYEK 1028
Query: 1281 EQTRLEAEFSKLKEQYQQLDITSTKLNN---QCELLSQLKGNLEEENRHLLDQIQTLMLQ 1337
+ +L+ E + +++ + +L N QCE + +N LL +I+TL
Sbjct: 1029 QSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCE-------TINSDNEDLLARIETLQSN 1081
Query: 1338 NRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1379
+ L Q +E + + +DK EL +K + E+KI +
Sbjct: 1082 AKLLEVQILEVQ-----RAKAMVDK--ELEAEKLQKEQKIKE 1116
Score = 169 bits (429), Expect = 2e-41
Identities = 260/1214 (21%), Positives = 528/1214 (43%), Gaps = 186/1214 (15%)
Query: 137 KKEEFIERIQGLDFDTKAAVAAH--IQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMA 194
+K+ +E + L + + ++ + E+ + +N+ + + + +SQ D +LK +
Sbjct: 529 EKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDT--MLKELE 586
Query: 195 LHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
+ L +E+D+ + EE D H K+ E + L +EL
Sbjct: 587 GKINSLTEEKDDFINKLKNSHEEMDNFH------------------KKCEREERLILELG 628
Query: 255 DAKAKIRRLRQELEEKTEQLL----DCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
+ + ELE+K +L + +E +Q + +L++L + M +LS+ + +
Sbjct: 629 KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQ-MKVLSEDKE--VLSA 685
Query: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
E+ +L E+ ++ + ++SR D+E + ++ E++ +L E T LE +L+
Sbjct: 686 EVKSLYEENNKLSSEKKQLSR------DLEVFLSQKEDV-----ILKEHITQLEKKLQLM 734
Query: 371 RARSDKLHEL-EKENLQ---LKAKLHDM------EMERDMDRKKI--------------- 405
D L++L E E +Q +K +L+ E+ D + K +
Sbjct: 735 VEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKIN 794
Query: 406 -----------EELMEENMTLEMAQKQSMDE-----SLHLGWELEQISRTSELSE--APQ 447
E+++E ++ Q++S+ + SL +E E++ EL E + +
Sbjct: 795 EEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEK 854
Query: 448 KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV 507
++L ++ E+ ++ K +ENQ+L VEE+ T E + K KE++ L +
Sbjct: 855 EALQSDLLEMKNANE-KTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913
Query: 508 EILE-----NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEH 562
E E E++ K SL ++ D + +LE+ IE L K +++ E
Sbjct: 914 EQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE-------KECKEKEEK 966
Query: 563 LNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK- 621
+N+ + + A+ + KE + + E ++ S+ ++ R + + E YK
Sbjct: 967 INKI-----KLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKN 1021
Query: 622 ---EKGERAEELENE---LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
E +++E+L+ E ++ E E L +++ N + CE I NS+ E ++
Sbjct: 1022 LLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI------NSDNEDLLARI 1075
Query: 676 KKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKELESEK 734
+ + K L Q+ +++ + +D+E E + + +K + + +L+ +L+ EK
Sbjct: 1076 ETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEK 1135
Query: 735 EQLKKG---LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
+QL+K LEL+K ++T + + + + L + L N N KI+ LE E++ +
Sbjct: 1136 KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQ 1195
Query: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
+ +TLQ+ + L+ S ++ E+ + K L +T + D KQ E ++ L QA +K
Sbjct: 1196 KQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDH--LILQASLK--- 1250
Query: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRL-KELEKENKELVKRATIDIKTLVTLRED 910
G LE +++ +YK + E K ++ L A +TL ++
Sbjct: 1251 --------GELEAS----QQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQR 1298
Query: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLE 970
+ + + + + + +T E E + +L +++ S+ + +K E E
Sbjct: 1299 VTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQER------E 1352
Query: 971 IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKW 1030
E I L+ +L++S N Q EL+T++ ++ L +R +
Sbjct: 1353 HLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHN------------------ 1394
Query: 1031 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL-KQLETQNNNLQAQILALQ-- 1087
+ QET + +++++L ++ N +++E +QL Q E N+ + Q+ LQ
Sbjct: 1395 -KMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEE 1453
Query: 1088 -RQTV-SLQEQNTTLQTQNAKLQVENSTLN--SQSTSLMN----QNAQL-LIQQSSLENE 1138
R+TV +LQ+Q + ++ Q +L+ E +T + S SL N +N L L+ ++ E
Sbjct: 1454 HRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTRE 1513
Query: 1139 ---------NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHK 1189
ESV +SL L KLE E L+ K + +
Sbjct: 1514 EGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSAD 1573
Query: 1190 NLEVEHRDLEDRYNQLLKQ----KGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCG 1245
+L R+ E L++Q K ++ LE+ + E+ LE + + + K
Sbjct: 1574 HLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGS 1633
Query: 1246 ENDRLNHTYSQLLK 1259
E +RL + +L+
Sbjct: 1634 ERERLLPVINTMLQ 1647
Score = 166 bits (419), Expect = 3e-40
Identities = 270/1252 (21%), Positives = 526/1252 (42%), Gaps = 207/1252 (16%)
Query: 262 RLRQELEEKTEQLLDCKQELEQMEI----ELKRLQQENMNL--------------LSDAR 303
+++QE+E+ ++ D +ELEQ I E++ L+ E M + L +A
Sbjct: 101 KMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAM 160
Query: 304 SARM-YRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM 362
+ ++ ++L V KL+ E+ + + + Y + + D + ET T
Sbjct: 161 NTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEK--KETVTQ 218
Query: 363 LEDQLEGTRARSDK-LHELEKENLQLKAKLHDMEM------------ERDMDRKKIEELM 409
L++ +E K ++ L++E LQLKA +H E+ E + + K+ EL
Sbjct: 219 LQNIIEANSQHYQKNINSLQEELLQLKA-IHQEEVKELMCQIEASAKEHEAEINKLNEL- 276
Query: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
+EN+ + Q ++ ++++ +E E + S A Q N++ S L +
Sbjct: 277 KENL---VKQCEASEKNIQKKYECELENLRKATSNANQD------NQICSILLQENTFVE 327
Query: 470 QSLTKTVEELRTTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ 525
Q + + V+ L T+ +E S ++ M +L + +++E E++ L+
Sbjct: 328 QVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKI 387
Query: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA----EAR 581
N +L+ K + IE L+ K E N+ V SL+++ Q E
Sbjct: 388 N---ELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETF 444
Query: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK--------EKGERAEELENE 633
+ D EKE L I+ + ++ EK++ E + E GE A ++ E
Sbjct: 445 LSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQE 504
Query: 634 LHHLEKE-----NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQ 688
++++ +EL QK L+ + +AL + + L+ EN KL + L
Sbjct: 505 FESMKQQQASDVHELQQK----LRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENT 560
Query: 689 LESLEKEN-------SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
+++L+++N SQ D EL + SL +E + +LK
Sbjct: 561 IKNLQEKNGVYLLSLSQRDTMLKELEGKINSL-------------TEEKDDFINKLKNSH 607
Query: 742 ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ-------LESELQDLEMENQ 794
E + KK ER E L +++++T++ +++ Q+ LE L++ + +Q
Sbjct: 608 EEMDNFHKKCEREERLILEL---GKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQ 664
Query: 795 TLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE 854
L+K + ++K+ S+ E L E KSL +E ++L +KKQL ++ + Q E D L+E
Sbjct: 665 KLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKE--DVILKE 722
Query: 855 NNVKI-----------GNLEK--ENKTLS------------KEIG--------------- 874
+ ++ NL K EN+ + KE+G
Sbjct: 723 HITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNV 782
Query: 875 ----------IYKESC-------VRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917
I +E C ++ ELEKE K L + + + + L +L D EK+
Sbjct: 783 LQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKV- 841
Query: 918 TQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLL--ESKLESTLKKSLEIKEEK 975
+ +LE++ E E + + + + + T LL ++ T KS EI EK
Sbjct: 842 --LLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKS-EIHNEK 898
Query: 976 IAALEARLEESTNYNQQLRQ-ELKTVKKNYEALKQRQDEERMVQSSPPISGED-----NK 1029
++E N L Q EL+ + LK + V++ P S ++
Sbjct: 899 EKCF---IKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIEN 955
Query: 1030 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1089
E+E +E ++ K+K ++ ++ + + E Q +K +L+ L ++ + L A + L +
Sbjct: 956 LEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQG 1015
Query: 1090 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL 1149
S + + Q+ +L VE N+ + + QL + S+L + E++ + EDL
Sbjct: 1016 AESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQL--RNSTL--QCETINSDNEDL 1071
Query: 1150 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1209
+ ++L + + LE+ ++ K LE E E + +
Sbjct: 1072 LARIETLQSNAKLLEV----------QILEVQRAKAMVDKELEAEKLQKEQKIKEHATTV 1121
Query: 1210 GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHK 1269
+LE+L+ L+ E++++ + E V + ++ N + Y +L+KE T+
Sbjct: 1122 NELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEI-ADYERLMKELNQKLTNKN 1180
Query: 1270 N----LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENR 1325
N L+ + K +Q L+ E + L+ QQ + +TK+ +LL + K L + +
Sbjct: 1181 NKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIK---QLLVKTKKELADSKQ 1237
Query: 1326 HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
D + L + LE + + +++ ++ L E+ +K K+ E +
Sbjct: 1238 AETDHL-ILQASLKGELEASQQQVEVYKIQ-------LAEITSEKHKIHEHL 1281
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 194 bits (492), Expect = 9e-49
Identities = 264/1230 (21%), Positives = 539/1230 (43%), Gaps = 167/1230 (13%)
Query: 256 AKAKIRRLRQELEEKTEQLLDCKQELEQ---------MEIELKRLQ--QENMNLLSDARS 304
A+ K+ RL +EL ++ + D K EL Q ++ EL ++Q +NM L + S
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
Query: 305 ARMYRDELDALREK----AVRVDKLESEVSRYKERL----HDIEFYKARVEELKEDNQVL 356
++ +DE L+ + + +L SE+++ + + +++ K+ V EL + NQ L
Sbjct: 249 EKL-KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTL 307
Query: 357 LETKTMLEDQLEGTRARSDKLHE-LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTL 415
T+ +L+ + + T+ E + K+N+Q D++ ++ R E + +
Sbjct: 308 --TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHV 365
Query: 416 EMAQK----QSMDESL--------HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLL 463
E+++K Q + E L HL E +Q+ + E E L E+N+L S+LL
Sbjct: 366 ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL-HSKLL 424
Query: 464 KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQN 523
+ E + ++E R ++ K++ E++ L K+ LE ++ K+ + N
Sbjct: 425 ETERQLGEAHGRLKEQRQL------SSEKLMDKEQQVADLQLKLSRLEEQL---KEKVTN 475
Query: 524 CQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVK 583
L L K K Q QE + L Q+ ++ + +Q E ++
Sbjct: 476 STELQHQLDKTKQQ-------------------HQEQQALQQSTTAKLREAQNDLEQVLR 516
Query: 584 DI-EKENKI--LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
I +K+ KI L ++++ +S +E E+ + +++ +GE A L+ L+++
Sbjct: 517 QIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ--AGEGETAV-----LNQLQEK 569
Query: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLD 700
N LQ+++T L KLK +S K ++ E + Q+
Sbjct: 570 NHTLQEQVTQL--------------------TEKLKNQSESHK------QAQENLHDQVQ 603
Query: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK-KTERLEVSYQ 759
E+ LR A ++ L+ EL S+ + K+ + L K KTE L +
Sbjct: 604 EQKAHLR-------AAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEA 656
Query: 760 GLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK- 818
+ LQ L+ + +Q + EL + + + L++ + +LE KE K
Sbjct: 657 AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKE 716
Query: 819 ---SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGI 875
SLEQ+T +LE K+LE ++ ++ E L++ +LE LSK++ +
Sbjct: 717 KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEM 776
Query: 876 YKE--SCVRLKELEKENKEL---VKRATIDIKTLVTLREDLVS----EKLKTQQMNNDLE 926
KE S RL +L+K+++ L ++ T + L++D + K++ +++NN ++
Sbjct: 777 EKEIVSSTRL-DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQ 835
Query: 927 KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIA--------- 977
EL+K+ + KE L+ + + D K+ +S S + E ++ K A
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCK 895
Query: 978 ----ALEARLEESTNYNQQLRQELKTVKKNYEALKQRQD--EERMVQSSPPISGEDNKWE 1031
L+ ++E + ++L++ L+ K+ LK + +E+++Q+ + E
Sbjct: 896 ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQN----E 951
Query: 1032 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1091
+E Q+ + ++K + ++ LQ E + Q +LE N LQ Q+ ++
Sbjct: 952 KEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE---NKLQQQLTQAAQELA 1008
Query: 1092 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1151
+ +E+ + LQ K Q T + + ++LL + L++ E + +EDL S
Sbjct: 1009 AEKEKISVLQNNYEKSQ---ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLIS 1065
Query: 1152 LYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ 1211
+ + ++ ++ L +A+ + K L+ K L+ ++ + +L+ +K +
Sbjct: 1066 NRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSK 1125
Query: 1212 LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL 1271
L ++E+ +K QEK + K +E + + + E L L+++ LQ +L
Sbjct: 1126 LAEIEE-IKCRQEKEI--TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSL 1182
Query: 1272 KSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQI 1331
K+ + K Q L+ + K +E ++ + + +L S++K +H ++
Sbjct: 1183 KAAVEQEKRNQQILKDQVKKEEE-----ELKKEFIEKEAKLHSEIKEKEVGMKKH--EEN 1235
Query: 1332 QTLMLQNRTLLEQNMES-KDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPR 1390
+ + T L +N+ + K + QR +++EL +Q + L +I +
Sbjct: 1236 EAKLTMQITALNENLGTVKKEWQSSQR----RVSELEKQTDDLRGEIAVLEATVQNNQDE 1291
Query: 1391 RRGNWITLKMRKLIKSKKDINRERQKSLTL 1420
RR + + +K + +I + + K L L
Sbjct: 1292 RRA-----LLERCLKGEGEIEKLQTKVLEL 1316
Score = 184 bits (468), Expect = 5e-46
Identities = 291/1301 (22%), Positives = 563/1301 (43%), Gaps = 183/1301 (14%)
Query: 118 TEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWM- 176
+EE+KK L G Q K + GL D+ A + + Q++ Q F+++ M
Sbjct: 106 SEELKKELEKYQGLQQQEAKPD-------GLVTDSSAELQSLEQQLEEAQTENFNIKQMK 158
Query: 177 ------------EVTDM-SQEDIEPLLKNMALH-LKRLIDERDEHSETIIELSEE---RD 219
E+ D+ S+ D E L+ A + RL +E ++ + I +L E R
Sbjct: 159 DLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRP 218
Query: 220 GLH---FLPHASSSAQSPCGSPGMKRTESRQHLSVEL-------ADAKAKIRRLRQELEE 269
G+ L Q+ + ++R + L E A ++A I +LR EL +
Sbjct: 219 GIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAK 278
Query: 270 KTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELD---------------A 314
+++ QEL++++ + L Q+N L + +L+
Sbjct: 279 GPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQAT 338
Query: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
L +K + +L+S +S + LH I + E E Q L E + +E + + +A
Sbjct: 339 LHQKDLDCQQLQSRLSASETSLHRIH---VELSEKGEATQKLKEELSEVETKYQHLKAEF 395
Query: 375 DKL----HELEKENLQLKA---KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427
+L E E+ LQL++ +LH +E + + ++E +++ ++ MD+
Sbjct: 396 KQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR--QLSSEKLMDKEQ 453
Query: 428 HLGWELEQISRTSE-LSEAPQKS--LGHEVNELTSSRLLKLEMENQSLTKTVE---ELRT 481
+ ++SR E L E S L H++++ + ++ + K E +L
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513
Query: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENE---IVQEKQSLQNCQNLSKDLMKEKAQL 538
+ + KI +E Q+ + + +LE E + + Q+ + + L ++ L
Sbjct: 514 VLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTL 573
Query: 539 EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE 598
++ + L E + Q + +Q E+L+ V + + +A+ RV +E L+ + E
Sbjct: 574 QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLR-AAQDRVLSLETSVNELNSQLNE 632
Query: 599 TSSKLSKIEFE-KRQIKKELEHYKEKGERAEELENEL----HHLEKENELLQKKITNLKI 653
+ K+S+++ + K + + L K + +L+N L + L+ + + L K T L
Sbjct: 633 SKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQ 692
Query: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
K++ ++ S+LE LK+ + + +L + E LE + +L+ ++LE++ + E
Sbjct: 693 VTAKLQDKQEHCSQLESH---LKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749
Query: 714 KCASMKMAQLQLE--------NKELESEKE----------QLKKGLELLKASF-KKTERL 754
+ QL + +K+LE EKE + + LE +K K+ E
Sbjct: 750 LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809
Query: 755 EVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLE 814
++ Q + +Q + E N +IQ +ELQ ++ME + L L +K ++L
Sbjct: 810 QILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK------DKLS 863
Query: 815 KENKSLEQETSQLEKDKKQ-------LEKENKRLRQQAEIK-DTTLEENNVKIGNLEKEN 866
K + SL+ S+ EK+ ++ LEK K L+ Q +++ + TL+E +LEKE
Sbjct: 864 KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK 923
Query: 867 KT---LSKEIGIYKESCVR----LKELEKENK-------ELVKRATIDIKTLVTLREDLV 912
+ L E+ +E ++ LK+ EKE + EL + + K + L+ +L
Sbjct: 924 EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983
Query: 913 SEKLKTQQMNNDL-EKLTHELEKIGLNKERL--LHDEQSTDDSRYKLLESKL---ESTL- 965
L+ ++ N L ++LT +++ KE++ L + +K L+S ES L
Sbjct: 984 IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1043
Query: 966 --KKSLEIKEEKIAALEARLEESTNY---NQQLRQELKTVKKNYE---ALKQRQDEERMV 1017
++ L+ EEK++ + L + N +L QELKT K E A K++Q +ER
Sbjct: 1044 ATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK 1103
Query: 1018 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1077
+ +D + E+ +E +EL+ K +L E+E Q K++ N
Sbjct: 1104 ------ALQDIQKEKSLKE--KELVNEKSKLAEIEEIKC----------RQEKEITKLNE 1145
Query: 1078 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1137
L++ L ++ +L++ L Q +LQ + +L + + +N Q+L Q ++
Sbjct: 1146 ELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKA-AVEQEKRNQQILKDQ--VKK 1202
Query: 1138 ENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD 1197
E E + KE + ++ S IK+ E HE ++ I+ + ++NL ++
Sbjct: 1203 EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQIT------ALNENLGTVKKE 1256
Query: 1198 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1257
+ ++ + + Q +DL + V + ++N E A + L GE
Sbjct: 1257 WQSSQRRVSELEKQTDDLRGEIAVLE--ATVQNNQDERRALLERCLKGEG---------- 1304
Query: 1258 LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQ 1298
E E LQT L+ L+N+ L E L+ ++ Q
Sbjct: 1305 --EIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQ 1343
Score = 184 bits (467), Expect = 7e-46
Identities = 232/1025 (22%), Positives = 450/1025 (43%), Gaps = 145/1025 (14%)
Query: 185 DIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTE 244
++E +++ K+L +R+E + ++L E + LH + G + E
Sbjct: 383 EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH---SKLLETERQLGEAHGRLKE 439
Query: 245 SRQHLSVEL-------ADAKAKIRRLRQELEEKTEQLLDCKQELE---QMEIELKRLQQE 294
RQ S +L AD + K+ RL ++L+EK + + +L+ Q E + LQQ
Sbjct: 440 QRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQS 499
Query: 295 NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYK----------- 343
L +A++ L + +K ++ LE+ + + KE + +E +
Sbjct: 500 TTAKLREAQND--LEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGE 557
Query: 344 ---ARVEELKEDNQVLLETKTMLEDQL----EGTRARSDKLHELEKEN-----------L 385
A + +L+E N L E T L ++L E + + LH+ +E L
Sbjct: 558 GETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVL 617
Query: 386 QLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEA 445
L+ ++++ + + ++K+ +L +++ K + S ++ + L A
Sbjct: 618 SLETSVNELNSQLNESKEKVSQL-----DIQIKAKTELLLSAEAAKTAQRADLQNHLDTA 672
Query: 446 PQ--KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503
+ E+N++T+ +L+ L E ++ K L +E++ + L
Sbjct: 673 QNALQDKQQELNKITT----QLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEEL 728
Query: 504 SKKVEILENEIVQEK-------QSLQNCQNLSKDLMKEKAQLEKTIETLRE---NSERQI 553
+++ LE + ++ K Q LQ + L+ DL +L K +E +E ++ +
Sbjct: 729 EGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDL 788
Query: 554 KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHES----IKETSSKLSKIEFE 609
+ + E + Q ++ + QI + + + +E KI HE I+ T ++L K++ E
Sbjct: 789 QKKSEALESIKQKLTKQEEEKQILKQD-FETLSQETKIQHEELNNRIQTTVTELQKVKME 847
Query: 610 KRQIKKELEHYKEKGER-AEELENELHHLEKENELLQKKITNLKITCEKIE-ALEQENSE 667
K + EL K+K + ++ L+N EKEN+ + I +L+ TC++++ L+ +
Sbjct: 848 KEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMEN 907
Query: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
+E ++LKK+L+ K + QL+ +L+ +L + +LK + QLQ
Sbjct: 908 TLKEQKELKKSLEKEKEASHQLKL------ELNSMQEQLIQAQNTLKQNEKEEQQLQGNI 961
Query: 728 KELESEKEQLKKGLELLKASFK-----KTE-------RLEVSYQGLDIENQR---LQKTL 772
EL+ EQ KK +E L+ K KTE +L + Q L E ++ LQ
Sbjct: 962 NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021
Query: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKK 832
E S + +QL+S+ E E L ++LK ++L +++ S + K +
Sbjct: 1022 EKSQETFKQLQSDFYGRESE---LLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI--------GIYKESCVRLK 884
+L+ L Q + K+ L+E + +++KE KE+ I + C + K
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEK 1138
Query: 885 ELEKENKELVKRATIDIKTLVTLRED---LVSEKLKTQQMNNDLEKLTHELEKIGLNKER 941
E+ K N+EL IK + L++ L+ +KL+ Q + L K E EK ++
Sbjct: 1139 EITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSL-KAAVEQEK---RNQQ 1194
Query: 942 LLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEES--TNYNQQLRQELKT 999
+L D+ ++ K + +E K EIKE+++ + E+ T L + L T
Sbjct: 1195 ILKDQVKKEEEELK--KEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGT 1252
Query: 1000 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1059
VKK +++ ++R E E+++ + E+ ++ + +NN Q
Sbjct: 1253 VKKEWQSSQRRVSE----------------LEKQTDDLRGEIAVLEATV----QNN---Q 1289
Query: 1060 AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQST 1119
E++AL + + E + LQ ++L LQR+ NTT Q +L EN +L + T
Sbjct: 1290 DERRALLERCLKGEGEIEKLQTKVLELQRKL-----DNTTAAVQ--ELGRENQSLQIKHT 1342
Query: 1120 SLMNQ 1124
+N+
Sbjct: 1343 QALNR 1347
Score = 150 bits (379), Expect = 1e-35
Identities = 239/1070 (22%), Positives = 456/1070 (42%), Gaps = 164/1070 (15%)
Query: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN-------ELHHLEKENEL 643
+L + +++ + L + ++ ++KKELE Y+ ++ + + EL LE++ E
Sbjct: 87 LLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEE 146
Query: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL--------TFQLESLEKE 695
Q + N+K + + EQ+ ++L E +K D ++L T E L KE
Sbjct: 147 AQTENFNIK---QMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKE 203
Query: 696 NSQLDEENLEL--RRNVESLKCASMKMAQLQ--LENKELESEKE---------------- 735
+ + + EL R +E + ++ Q+Q ++N LE E+E
Sbjct: 204 ATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYA 263
Query: 736 -----------QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL---ENSNKKIQQ 781
+L KG + + ++ ++L+ S L +NQ L + L E K+++
Sbjct: 264 SSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 323
Query: 782 -----------LESELQDLEMENQTLQKNLEELKISSKR----LEQLEKENKSLEQETSQ 826
+++ L +++ Q LQ L + S R L + + + L++E S+
Sbjct: 324 KHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSE 383
Query: 827 LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKEL 886
+E + L+ E K+L+QQ E K+ + +I L + +++G E+ RLKE
Sbjct: 384 VETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLG---EAHGRLKEQ 440
Query: 887 EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE 946
+ + E + + L L+ + E+LK + N+ +L H+L+K + +
Sbjct: 441 RQLSSEKLMDKEQQVADL-QLKLSRLEEQLKEKVTNS--TELQHQLDKTKQQHQEQQALQ 497
Query: 947 QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1006
QST ++ + ++ LE L++ + K++KI LEA L++S L +E + + +A
Sbjct: 498 QST-TAKLREAQNDLEQVLRQ-IGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
Query: 1007 -------LKQRQDEERMVQSSPPISGEDNKWERES------------QETTRELLKVKDR 1047
L Q Q++ +Q E K + ES QE L +DR
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
Query: 1048 LIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ-RQTVSLQEQNTTLQTQNAK 1106
++ +E + L ++ K ++ QL+ Q +L+ + +T + L T
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 1107 LQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE-L 1165
LQ + LN +T L A+L +Q ++ ES +KE K Y SL + E+LE
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHC-SQLESHLKE---YKEKYLSLEQKTEELEGQ 731
Query: 1166 LHERQASEYESLISKHGTLKSAH-----------------KNLEVEHRDLEDRYNQLLKQ 1208
+ + +A E SK L+ K LE+E + L K+
Sbjct: 732 IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791
Query: 1209 KGQLEDL-EKMLKVEQEKMLLENKNHETVAAEYKKLCGE-NDRLNHTYSQLLK---ETEV 1263
LE + +K+ K E+EK +L+ ++ ET++ E K E N+R+ T ++L K E E
Sbjct: 792 SEALESIKQKLTKQEEEKQILK-QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEA 850
Query: 1264 LQTDHKNLKSLLN--NSKLEQTRLEAEFSKLKEQYQQLDITST----------KLNNQCE 1311
L T+ +K L+ + L+ ++ E E K + LD+ T ++ N +
Sbjct: 851 LMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLK 910
Query: 1312 LLSQLKGNLEEEN------RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNE 1365
+LK +LE+E + L+ +Q ++Q + L+QN + E++Q +NE
Sbjct: 911 EQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK-------EEQQLQGNINE 963
Query: 1366 LRR---QKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTP 1422
L++ QK+K E + + K ++ ++L ++ +++ E++K L
Sbjct: 964 LKQSSEQKKKQIEALQGELKI----AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1019
Query: 1423 TRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTE 1482
S E F QL D S + +D +++ K S DL+ + G +
Sbjct: 1020 NYEKSQETFKQL-QSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ 1078
Query: 1483 NLEVPD---DISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNK 1529
L+ + + K+ ++L + + + K+LVN K
Sbjct: 1079 ELKTAKATLEQDSAKKEQQLQERCKA-----LQDIQKEKSLKEKELVNEK 1123
Score = 63.2 bits (152), Expect = 2e-09
Identities = 114/504 (22%), Positives = 212/504 (42%), Gaps = 61/504 (12%)
Query: 59 LESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQ-----QLIMMSLPNVLIIGKNPF 113
L+ ++ K++ + ++M N +++K ++ + +L + S+ LI +N
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 114 SEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDL 173
+ EE ++L + ++K++ IE +QG + K AV + Q+ +
Sbjct: 948 KQNEKEE-QQLQGNINELKQSSEQKKKQIEALQG---ELKIAVLQKTELENKLQQQL--T 1001
Query: 174 QWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQS 233
Q + +E I L N + + + EL R L + S AQ
Sbjct: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
Query: 234 PCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ 293
S + ++ L EL AKA L Q+ +K +QL + + L+ ++ E ++
Sbjct: 1062 DLIS-NRNQIGNQNKLIQELKTAKAT---LEQDSAKKEQQLQERCKALQDIQKEKSLKEK 1117
Query: 294 ENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353
E +N +S +E+ +EK + KL E+ + H +E K + LK+
Sbjct: 1118 ELVN----EKSKLAEIEEIKCRQEK--EITKLNEEL-----KSHKLESIK-EITNLKDAK 1165
Query: 354 QVLLETKTMLEDQLEGTRA------RSDKL---------HELEKENLQLKAKLHDMEMER 398
Q+L++ K L+ + + +A R+ ++ EL+KE ++ +AKLH E+
Sbjct: 1166 QLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEK 1225
Query: 399 DMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELT 458
++ KK EE E +T+++ ++ W+ Q R SEL E L E+ L
Sbjct: 1226 EVGMKKHEE-NEAKLTMQITALNENLGTVKKEWQSSQ-RRVSEL-EKQTDDLRGEIAVLE 1282
Query: 459 SS-------------RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSK 505
++ R LK E E + L V EL+ +D+ + + ++ +ENQ L
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNT---TAAVQELGRENQSLQI 1339
Query: 506 KVEILENEIVQEKQSLQNCQNLSK 529
K N E +QNC K
Sbjct: 1340 KHTQALNRKWAEDNEVQNCMACGK 1363
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 192 bits (489), Expect = 2e-48
Identities = 257/1188 (21%), Positives = 524/1188 (44%), Gaps = 122/1188 (10%)
Query: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE--NMNLLSDARSARMYR- 309
L + K K + Q LE + LL ++ + ELK LQ+E MNLL+ + R
Sbjct: 1852 LEEEKQKNKEFSQTLENEKNTLLS---QISTKDGELKMLQEEVTKMNLLNQQIQEELSRV 1908
Query: 310 --------DELDALREKAV-RVDKLESEVSRYKERLHDIEF-----------YKARVEEL 349
+E D L E+ + ++ +L + Y + + D + K V EL
Sbjct: 1909 TKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSEL 1968
Query: 350 KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409
+E+ Q L++ KT +E ++ R + L +++ + K H E++ + K+ E
Sbjct: 1969 EEEKQQLVKEKTKVESEI-----RKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQ 2023
Query: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVN-------ELTSSRL 462
+ + +K S E E Q +L E +++L V EL S ++
Sbjct: 2024 LQKDCIRYQEKISALERTVKALEFVQTESQKDL-EITKENLAQAVEHRKKAQAELASFKV 2082
Query: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQ 522
L + ++++ + L+ + S +M+++++ L +++E E + ++EK+++Q
Sbjct: 2083 LLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQ 2142
Query: 523 NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA---E 579
+ L +EK LE+TI ++ ++ K ++Q E+L+ TV+ L ++ + +
Sbjct: 2143 EKLDA---LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639
R + I++ K + SK +I ++ + ++ EEL+ + LE
Sbjct: 2200 DRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEH 2259
Query: 640 ENELLQKKI-TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698
+ ++ + K T +++ + + L+ EN EL + + + S +N +L LE E
Sbjct: 2260 DKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQN---ELAKLESELKS 2316
Query: 699 LDEENLELRRNVESLKCASMK------MAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
L ++ +L ++E KC K + Q + + + + EQL+ L+ AS + T
Sbjct: 2317 LKDQLTDLSNSLE--KCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQ---ASRELTS 2371
Query: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ 812
RL ++ ++++ Q++ L + IQ +EL+ Q K ++EL+ + E+
Sbjct: 2372 RL---HEEINMKEQKIISLLSGKEEAIQVAIAELR------QQHDKEIKELENLLSQEEE 2422
Query: 813 ----LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE--IKDTTLEENNVK--IGNLEK 864
LE+ENK +T+QL + K ++KEN + + Q + +K + +N+ +G+ ++
Sbjct: 2423 ENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQ 2482
Query: 865 ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND 924
+ + + I E ++E EN +L + +I+ L + +DL SE K
Sbjct: 2483 LEE---RHLSIILEKDQLIQEAAAENNKLKE----EIRGLRSHMDDLNSENAKLDAELIQ 2535
Query: 925 LEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE 984
+ +++ I ++++ L + Q + + +KLE LK+S E E+ + A E
Sbjct: 2536 YREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQE 2595
Query: 985 ESTNYNQQLRQELKTVKKNYEALKQR----QDEERMVQSSPPISGEDNKWERES---QET 1037
E Q L +E++++K + L ++ Q+E + + ++ + R S +
Sbjct: 2596 EK----QDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSS 2651
Query: 1038 TRELLKVKDRLIEVERNNATLQAE-KQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096
+ + ++++ L+ V++ A E + LK +LK L ++ + + + L
Sbjct: 2652 QKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD 2711
Query: 1097 NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1156
++ + + EN L +Q S SSL+N + +E ++LK YD+
Sbjct: 2712 LVEMEQKLLMVTKENKGLTAQIQSFGRS-------MSSLQNSRDHANEELDELKRKYDAS 2764
Query: 1157 IKDHEKLE----LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL 1212
+K+ +L+ L ER A E+ S + T +++ +LE ++ L + QLL QL
Sbjct: 2765 LKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824
Query: 1213 EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLK 1272
ED ++ + M + + E +K + + +Q +Q+ K +
Sbjct: 2825 EDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMS 2884
Query: 1273 SLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQ 1332
SL N ++ RL E L++QY Q +N + L LK L+E D+ +
Sbjct: 2885 SLQN----DRDRLLKELKNLQQQYLQ-------INQEITELHPLKAQLQEYQ----DKTK 2929
Query: 1333 TLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380
+ L ++N+ + H + + RR KE+ I D+
Sbjct: 2930 AFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDK 2977
Score = 183 bits (465), Expect = 1e-45
Identities = 315/1586 (19%), Positives = 664/1586 (41%), Gaps = 227/1586 (14%)
Query: 249 LSVELADAKAKIRRLRQELEEKTEQLLD--------------CKQELEQMEIELKRLQQE 294
+ ++ ++ IR L+ +L+ K ++L+ Q L Q E+E+ ++ Q
Sbjct: 822 VQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQL 881
Query: 295 NMNLLSDARSARMYRDELD--------ALREKAVRVDK----LESEVSRYKERLHDIE-F 341
+ D + + +E D ++ EK V++++ L E+ KE+L+ +
Sbjct: 882 LLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRA 941
Query: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL-HE---LEKENLQLKAKLHDMEME 397
+A+ E+++EDN+V K ++ + ++L HE L+KEN Q K KL +
Sbjct: 942 EEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALIN 1001
Query: 398 RDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457
R +++ L EE L+ K+ + S E+E+ E SE S E+
Sbjct: 1002 RKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIY 1061
Query: 458 TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK--MEKENQRLSKKVEILENEIV 515
+ + E+E Q + K +EE + + ++ + +K NQ + EI EN+ +
Sbjct: 1062 LKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAI 1121
Query: 516 QEKQSLQNCQNLSKD---LMKEKAQLEK----TIETLRENSERQIKILEQENEHLNQTVS 568
+K N D L+KE + + E + E +I LE+E E L + +
Sbjct: 1122 IQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL- 1180
Query: 569 SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE 628
Q + S +A +K +++ + L E +K+ ++++ E + E+ + E
Sbjct: 1181 ---QEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQ----------EQFDEQSKENE 1227
Query: 629 ELENELHHLE-KENELLQKKI--TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685
+ ++L L+ + E + K+ T+ + +C LE+ + E + L+S NL
Sbjct: 1228 NIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFK-ATEQHHTQPVLES--NL 1284
Query: 686 TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK 745
S ++ S L +AQ++ + KE+E+EK +L+ +
Sbjct: 1285 CPDWPSHSEDASALQ---------------GGTSVAQIKAQLKEIEAEKVELELKVSSTT 1329
Query: 746 ASF-KKTERL-----EVSYQGLDIEN------------QRLQKTLENSNKKIQQLESELQ 787
+ KK+E + +++ QGL+IE+ + LQ+ LE+S +I LE L+
Sbjct: 1330 SELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLE-HLR 1388
Query: 788 DLEMENQTLQKNLEELKISSKRLE-QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
+L+ + LQK + + + L QL ++ +L + +++ + + ++ + +L QA+
Sbjct: 1389 ELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAK 1448
Query: 847 IKDTTLEENNVKIGNLEKENKTLSKEIGIYKE-------SCVRLKELEKENKELVKRATI 899
D +++ V++ ++++ + + +E ++ + + KE KENK L + ++
Sbjct: 1449 EHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSL 1508
Query: 900 DIKTLVTLREDLVSEKLKTQQMNND-------LEKLTHELEKIGLNKERLLHDEQSTDDS 952
T+ L + L + + N + L L E +K+ +R L + QS S
Sbjct: 1509 ARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSS 1568
Query: 953 RYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY---NQQLRQELKTVKKNYEALKQ 1009
+ L+ LE + ++ +E + +++ EST + +++L++E + + ++YE +
Sbjct: 1569 -CESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSN 1627
Query: 1010 RQDE-----ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQA 1064
+ E + Q + G+ E +ET ++L + + + E++ KQ
Sbjct: 1628 EAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQ- 1686
Query: 1065 LKTQLKQLETQNNNLQAQIL----ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTS 1120
++ +LE +N+ L+A++ + +L N +++ + ++++E TL+ + S
Sbjct: 1687 --QKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQS 1744
Query: 1121 LMNQNAQLLIQQSSLENENESVIKEREDLKSL--YDSLIKDHEKLELLHERQASEYESL- 1177
LM++ L + L+++ E + ++ +L++ +D+ E+ + E +SL
Sbjct: 1745 LMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLS 1804
Query: 1178 ISKHGT-------LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK----- 1225
+S T KSA+ + + D N L+Q QL++ L+ E++K
Sbjct: 1805 MSTRPTCSESVPSAKSANPAVSKDFSS-HDEINNYLQQIDQLKERIAGLEEEKQKNKEFS 1863
Query: 1226 MLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRL 1285
LEN+ + T+ ++ GE L +++ + +Q + + L ++ E+ L
Sbjct: 1864 QTLENEKN-TLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDL 1922
Query: 1286 E-------AEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQN 1338
E AE + Y Q D+T ++ N ELL NL++ L ++ Q L ++
Sbjct: 1923 EERLMNQLAELNGSIGNYCQ-DVTDAQIKN--ELLESEMKNLKKCVSELEEEKQQL-VKE 1978
Query: 1339 RTLLEQNMESKDLFHVE-------QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRR 1391
+T +E + + L ++ + + +L EL ++K++ +++ Y
Sbjct: 1979 KTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEK---- 2034
Query: 1392 RGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSS-----------EGFLQLPHQDSQ 1440
+ + +K+ + + E QK L +T + F L
Sbjct: 2035 -----ISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQS 2089
Query: 1441 DSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELG 1500
+++ V +++L+ + L + K S + + Q E+LE + + K KE
Sbjct: 2090 EAARVLADNLKLKKELQSNKESVKSQMKQ----------KDEDLERRLEQAEEKHLKEKK 2139
Query: 1501 AMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASL 1560
M A+ V+ Q+ NK + + Q D + T +SL
Sbjct: 2140 NMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL--QENLDSTVTQLAAFTKSMSSL 2197
Query: 1561 DSGR---------------TSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFS-----L 1600
R + + L E + +Q R S E L
Sbjct: 2198 QDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRL 2257
Query: 1601 LHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLE 1660
HD + W S + +Q LQ K+ +TL+ + ++ + T +
Sbjct: 2258 EHDKQIWESKAQTEVQ-----------LQQKVCDTLQGENKELLS----QLEETRHLYHS 2302
Query: 1661 ESNKLTSVQIKSSSQENLLDEVMKSL 1686
N+L ++ + S ++ L ++ SL
Sbjct: 2303 SQNELAKLESELKSLKDQLTDLSNSL 2328
Score = 182 bits (461), Expect = 3e-45
Identities = 282/1373 (20%), Positives = 578/1373 (42%), Gaps = 184/1373 (13%)
Query: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMAL 195
Q+ ++ ERI GL+ + + + N++N L + D + ++ + M L
Sbjct: 1840 QQIDQLKERIAGLEEEKQKN--KEFSQTLENEKNTL-LSQISTKDGELKMLQEEVTKMNL 1896
Query: 196 HLKRLIDERDEHSETIIELSEERDGLHF-LPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
+++ +E ++ EE+D L L + + G+ T+++ + EL
Sbjct: 1897 LNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQ--IKNELL 1954
Query: 255 DAKAK-IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL- 312
+++ K +++ ELEE+ +QL+ +E ++E E+++ E + + + EL
Sbjct: 1955 ESEMKNLKKCVSELEEEKQQLV---KEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ 2011
Query: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLE-TKTMLEDQLEGTR 371
+ L+EK V +L+ + RY+E++ +E +E ++ ++Q LE TK L +E +
Sbjct: 2012 ELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRK 2071
Query: 372 ARSDKLHELEKENLQLKAKLHDMEMERDM---DRKKIEELMEENMTLEMAQKQSMDESLH 428
+ + E K L D + E D K+++ ++ N +Q + DE L
Sbjct: 2072 -------KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLE 2124
Query: 429 LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
L +A +K L + N +L L E L +T+ E++ T++
Sbjct: 2125 -----------RRLEQAEEKHLKEKKN--MQEKLDALRREKVHLEETIGEIQVTLN---- 2167
Query: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
K +KE Q+L + ++ ++ +S+ + Q+ ++ E + E+ ++
Sbjct: 2168 ------KKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQS 2221
Query: 549 SERQIKILEQE--------------NEHLNQTVSSLRQRSQI---SAEARVK-------D 584
E +I++ E E L +S L QI A+ V+
Sbjct: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT 2281
Query: 585 IEKENKILHESIKET-------SSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHL 637
++ ENK L ++ET ++L+K+E E + +K +L E+ +E + L +
Sbjct: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGI 2341
Query: 638 EKENELLQKKITNLKITCEKIEALEQENSEL-----ERENRKLKKTLD--SFKNLTFQ-- 688
++ E I N K + E++E Q + EL E N K +K + S K Q
Sbjct: 2342 IRQQEA---DIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
Query: 689 -----------LESLEKENSQLDEENLELRR-NVESLKCASMKMAQLQLENKELESEKEQ 736
++ LE SQ +EEN+ L N +++ + M L+ KE +K Q
Sbjct: 2399 IAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ 2458
Query: 737 LKKGLELLKASFKKTERLEVSYQGLDI--------ENQRLQKTLENSNK---KIQQLESE 785
L ++ + + +R+ YQ L+ ++Q +Q+ +NK +I+ L S
Sbjct: 2459 LDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSH 2518
Query: 786 LQDLEMENQTLQKNLEE----------LKISSKR--LEQLEKENKSLEQETSQLEKDKKQ 833
+ DL EN L L + +K S ++ LE ++NK LE + ++LE+ K+
Sbjct: 2519 MDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578
Query: 834 LEKENKRLRQ-----QAEIKDTT--LEENNVKIGNLEKENKTLSKE--IGIYKESCVRLK 884
E+ N+ LR+ Q E +D + +E V I L ++ L +E +G+Y +LK
Sbjct: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYH---AQLK 2635
Query: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE-KLTHELEKIGLNKERLL 943
E+E L + K + L E+LV + + + ++E KL EL+ + + +
Sbjct: 2636 VKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMR 2695
Query: 944 HDEQSTDDSRYKLLESKLESTLKKSLEIKEEK-----IAALEARLEESTNYNQQLRQELK 998
++ ++ ++ +L +E K + KE K I + + N +EL
Sbjct: 2696 NETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELD 2755
Query: 999 TVKKNYEA------------LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKD 1046
+K+ Y+A L R+ + + +++ ++ + ++ ++LL +
Sbjct: 2756 ELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDE 2815
Query: 1047 RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK 1106
+L+ + + Q+ + L+ + ++L ++ ++ Q T A+
Sbjct: 2816 QLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAE 2875
Query: 1107 LQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK---L 1163
+Q +L +SL N +LL + +L+ + + +E +L L L + +K
Sbjct: 2876 VQ----SLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAF 2931
Query: 1164 ELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ-LEDLEKMLKVE 1222
+++ E E S + L+ + E+ R ++++Y + K Q L L+ +++
Sbjct: 2932 QIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIR-- 2989
Query: 1223 QEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ-LLKETEVLQTDHKNLKSLLNNSKLE 1281
++ + + + +Y++ + SQ L+ ETE+L+T + ++ +L
Sbjct: 2990 --ELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELR 3047
Query: 1282 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLM------ 1335
+L + FS+L E+ L I + Q G+L L Q+Q L
Sbjct: 3048 IQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI 3107
Query: 1336 ------------LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
+ ++ E+ E + F Q+Q + E+ ++ LEE+
Sbjct: 3108 DVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEE 3160
Score = 180 bits (456), Expect = 1e-44
Identities = 277/1347 (20%), Positives = 587/1347 (43%), Gaps = 192/1347 (14%)
Query: 142 IERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLI 201
++ I+ + + V++ E+T E VF LQ E + +IE L K +
Sbjct: 1311 LKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ--EQINKQGLEIESL--------KTVS 1360
Query: 202 DERDEHSETIIELSEERD----GLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAK 257
E + H+E++ + E GL L K+ E +LS +L++ +
Sbjct: 1361 HEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDE-LQKLISKKEEDVSYLSGQLSEKE 1419
Query: 258 AKIRRLRQELEEKTE-----------QLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
A + +++ E+ E+ + Q + + ++Q+++EL ++Q+ + ++R+ +
Sbjct: 1420 AALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQ 1479
Query: 307 MYRDELDAL---REKAVRVDK-LESEVS-------RYKERLHDIEFYKARVEELKEDNQV 355
+ +L A R++A++ +K L+ E+S R + L D+E ++V ++
Sbjct: 1480 QIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVE---SQVSAQNKEKDT 1536
Query: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQ-----LKAKLHDMEMERDMDRKKIEELME 410
+L +L+++ + D+ LE ++L LK L + +++ K+IE L
Sbjct: 1537 VLGRLALLQEERDKLITEMDR-SLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKS 1595
Query: 411 ENMTLEMAQKQSMDESLHLGWEL-----EQISRTSELSEAPQKSLGHEVNEL------TS 459
+ E + Q + L +E+ E +S +E + +++ E EL T
Sbjct: 1596 SKIA-ESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTE 1654
Query: 460 SRLLKLEMENQSLTKTVEELRTTVDS-VEGNASKILKMEKENQRLSKKVEILENEIVQEK 518
+ + E + Q + +EE++ + + KIL++E+EN RL +V + K
Sbjct: 1655 ANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTA---K 1711
Query: 519 QSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQ--I 576
+ ++ + + + +E +++ ETL ++ + L E + L++ V L+ + + +
Sbjct: 1712 ECMETLLSSNASMKEELERVKMEYETL----SKKFQSLMSEKDSLSEEVQDLKHQIEGNV 1767
Query: 577 SAEARVKDIEKENKILH------ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
S +A ++ EK + + +SI + + + R E + A
Sbjct: 1768 SKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSK 1827
Query: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN-LTFQL 689
+ H ++ N LQ+ I LK E+I LE+E +++N++ +TL++ KN L Q+
Sbjct: 1828 DFSSH--DEINNYLQQ-IDQLK---ERIAGLEEE----KQKNKEFSQTLENEKNTLLSQI 1877
Query: 690 ESLEKENSQLDEENLELRRNVESLKCASMKMAQL-QLENKELESEKEQLKKGLELLKASF 748
+ + E L EE ++ + ++ ++ +L + +E + +E+L L L S
Sbjct: 1878 STKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI 1937
Query: 749 KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808
+ Q I+N+ L+ ++N K + +LE E Q L E ++ + + +
Sbjct: 1938 GNYCQDVTDAQ---IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKI 1994
Query: 809 RLEQLEKENKSLEQETSQLEKDK----KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK 864
+ Q E NKS +E +L K+K KQL+K+ R +++ + T++ LE
Sbjct: 1995 QGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKA-------LEF 2047
Query: 865 ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE---------K 915
K++ I KE+ + E K+A ++ + L +D SE K
Sbjct: 2048 VQTESQKDLEITKENLAQAVEHR-------KKAQAELASFKVLLDDTQSEAARVLADNLK 2100
Query: 916 LKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEK 975
LK +++ ++ E + ++++ + ER L + K ++ KL++ ++ + + EE
Sbjct: 2101 LK-KELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHL-EET 2158
Query: 976 IAALEARLEESTNYNQQLRQELKTVKKNYEALKQ-----RQDEERMVQSSPPISGEDNKW 1030
I ++ L + QQL++ L + A + + D +R++ E KW
Sbjct: 2159 IGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVID-------EAKKW 2211
Query: 1031 ERESQETTRELLKVKDRLIEVERNNATLQAEK--------QALKTQLKQLETQ----NNN 1078
ER+ + ++ K+ I ++ +N ++ ++ + LK + +LE +
Sbjct: 2212 ERKFSDA----IQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESK 2267
Query: 1079 LQAQILALQRQTVSLQEQNTTL--------------QTQNAKLQVENSTLNSQSTSLMNQ 1124
Q ++ Q+ +LQ +N L Q + AKL+ E +L Q T L N
Sbjct: 2268 AQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNS 2327
Query: 1125 NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKD----HEKLELLHERQASEYESLISK 1180
+ Q+ +LE + ++ K Y+ L D E LHE + + +IS
Sbjct: 2328 LEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIIS- 2386
Query: 1181 HGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEY 1240
L + ++V +L ++++ +K +LE+L + + E+E ++LE +N
Sbjct: 2387 --LLSGKEEAIQVAIAELRQQHDKEIK---ELENL--LSQEEEENIVLEEEN-------- 2431
Query: 1241 KKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY---- 1296
KK + ++L T + KE + + +++ + ++ R+ ++ +L+E++
Sbjct: 2432 KKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSII 2491
Query: 1297 -------QQLDITSTKLNNQCELLSQLKGNLEEENRHL-LDQIQTLMLQNRTLLEQNMES 1348
Q+ + KL + L +L EN L + IQ N+ + ++ +
Sbjct: 2492 LEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQ 2551
Query: 1349 KDLFHVEQRQYIDKLNELRRQKEKLEE 1375
K L V+ +Q + N+ + +EKL+E
Sbjct: 2552 KQLLEVQLQQNKELENKYAKLEEKLKE 2578
Score = 169 bits (427), Expect = 3e-41
Identities = 278/1343 (20%), Positives = 559/1343 (41%), Gaps = 238/1343 (17%)
Query: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
+A ++++ Q L++KT Q+ + E+ + + +++L N +DA D + ++
Sbjct: 1091 QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSN----TDASDG----DSVALVK 1142
Query: 317 EKAVRVDKLESEVSRYKERLHD--IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
E V +K L + + K + + K+ + L K +L+ E R
Sbjct: 1143 ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKER--- 1199
Query: 375 DKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE 434
L +E Q K + ++ + D K+ E + ++ L++ ++S+D L + E
Sbjct: 1200 ----HLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE 1255
Query: 435 QISRTSELSEAPQKSLG-HEVNELTSSRLLK---LEMENQSLTK---TVEELRTTVDSVE 487
S T L E K+ H + S L E+ S + +V +++ + +E
Sbjct: 1256 SCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIE 1315
Query: 488 GNASKI-LKMEKENQRLSKKVEI---LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE 543
++ LK+ L+KK E L+ +I ++ +++ + +S + L++ +E
Sbjct: 1316 AEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
Query: 544 T-------------LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN- 589
+ L+ + K++ ++ E ++ L ++ + + + IE+E+
Sbjct: 1376 SSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435
Query: 590 -KILHESI----KETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH-------HL 637
K LH + KE ++ +++ E ++K++ E E+ ++++ +L
Sbjct: 1436 IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEA 1495
Query: 638 EKENELLQKKITNLKITCEKI-EALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696
KEN+ LQ++++ + T E++ ++L S++ +N++ L L + + L E
Sbjct: 1496 LKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM 1555
Query: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF-------- 748
+ EN L + ESLK A LE L +KE+L K +E LK+S
Sbjct: 1556 DRSLLENQSLSSSCESLKLA--------LEG--LTEDKEKLVKEIESLKSSKIAESTEWQ 1605
Query: 749 -------KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
K+ E L SY+ + E +R+Q +E ++ Q+L +L+ E + +K L+
Sbjct: 1606 EKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQ 1665
Query: 802 ELKISSKRL-EQLEKENKSLEQETSQLEKDKKQLEKE------------------NKRLR 842
E + + + E++ K KS +Q+ +LE++ +L E N ++
Sbjct: 1666 EAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMK 1725
Query: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC-------VRLKELEKENK---- 891
++ E E + K +L E +LS+E+ K L+ EK +
Sbjct: 1726 EELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNV 1785
Query: 892 ----------ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL---EKLTHELEKIGLN 938
E ++ ++ + T T E + S K ++ D +++ + L++I
Sbjct: 1786 TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQL 1845
Query: 939 KERL--LHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQE 996
KER+ L +E+ + + LE++ ++TL + K+ ++ L+ + + NQQ+++E
Sbjct: 1846 KERIAGLEEEKQKNKEFSQTLENE-KNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEE 1904
Query: 997 LKTVKKNYEALKQRQD--EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERN 1054
L V K E ++ +D EER++ ++G + ++ + ++K+ L+E E
Sbjct: 1905 LSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDA-----QIKNELLESEMK 1959
Query: 1055 N-----ATLQAEKQAL----------------------------KTQLKQLETQNNNLQA 1081
N + L+ EKQ L K+ K+L+ Q
Sbjct: 1960 NLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQ 2019
Query: 1082 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES 1141
++ LQ+ + QE+ + L+ L+ + AQ + + + E S
Sbjct: 2020 EVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELAS 2079
Query: 1142 VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR 1201
+D +S ++ D+ KL+ + S ES+ S+ +K ++LE R LE
Sbjct: 2080 FKVLLDDTQSEAARVLADNLKLK---KELQSNKESVKSQ---MKQKDEDLE---RRLEQA 2130
Query: 1202 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE---TVAAEYKKLCGENDRLNHTYSQLL 1258
+ LK+K ++ EK+ + +EK+ LE E T+ + K++ + L+ T +QL
Sbjct: 2131 EEKHLKEKKNMQ--EKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLA 2188
Query: 1259 KETEVLQTDHKNLKSLLNN-------------SKLEQTRL-EAEFSKLKEQYQQLDITST 1304
T+ + + + +++ SK E+ RL E S LK+Q +Q+ I
Sbjct: 2189 AFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHME 2248
Query: 1305 KLNNQCELLSQLKGNLEEENRHLLDQIQ-----TLMLQNRTLLEQNMESKDLFHVEQRQY 1359
+L L K + E Q+Q TL +N+ LL Q E++ L+H Q
Sbjct: 2249 ELKINISRLEHDK-QIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQ--- 2304
Query: 1360 IDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLT 1419
NEL + + +L KS KD + SL
Sbjct: 2305 ----NELAKLESEL-------------------------------KSLKDQLTDLSNSLE 2329
Query: 1420 LTPTRSDSSEGFLQLPHQDSQDS 1442
+ + EG ++ D Q+S
Sbjct: 2330 KCKEQKGNLEGIIRQQEADIQNS 2352
Score = 158 bits (399), Expect = 5e-38
Identities = 314/1566 (20%), Positives = 665/1566 (42%), Gaps = 275/1566 (17%)
Query: 83 VRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFI 142
+ +IK QE ++ ++ +L L + Q + E+++ +++ Q Q+KEEFI
Sbjct: 146 IEKIKHKLQE--KEELISTLQAQLTQAQAEQPAQSSTEMEEFVMM----KQQLQEKEEFI 199
Query: 143 ERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD-----MSQEDIEPLLKNMALHL 197
+Q T+A AA Q+V ++ F+ Q D ++Q D+E ++ L
Sbjct: 200 STLQAQLSQTQAEQAA--QQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVL 257
Query: 198 KRLIDERDEH---SETIIEL-------SEERDGL--HFLPHASSSAQSPCGSPGMKRTES 245
+R ++E +E +++L +E+R+ + L + + + +R ES
Sbjct: 258 QRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREES 317
Query: 246 R---QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN------- 295
+ + + +E+A+ K L++E+ EQ Q ++E L+Q++
Sbjct: 318 KILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEK 377
Query: 296 -MNLLSDARSARMYRDELDALREK---------------AVRVDKLE-------SEVSRY 332
++LS ++ + + DAL+++ A + +LE E+S++
Sbjct: 378 TSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQF 437
Query: 333 KERL----HDI-------EFYKARVEELKEDNQVLLETKTM-LEDQLEGTRARSDKLHEL 380
RL H+ + Y + + E+N L+ + + LE++ S +L EL
Sbjct: 438 LNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEEL 497
Query: 381 EKENLQLKAKLHDMEMER---DMDRKKIEELMEENMTLEMAQKQ--SMDESLHLGWELEQ 435
+ EN +L +++ +E + + DR+ + E +++A K+ S +ES E
Sbjct: 498 KAENEKLSSQITLLEAQNRTGEADRE-----VSEISIVDIANKRSSSAEESGQDVLENTF 552
Query: 436 ISRTSELSE--APQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL--RTTVDSVEGNAS 491
+ ELS K E+ LKL+++ + + E+ + + +EG
Sbjct: 553 SQKHKELSVLLLEMKEAQEEI------AFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGI 606
Query: 492 KILKMEKENQRLSKKVEILENE------IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL 545
+KM+ + + ++ NE + +E+ S ++ S+++ A +E +++
Sbjct: 607 APIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVE--LKST 664
Query: 546 RENSERQIKIL-------EQENEHLNQTVSSL-------RQRSQISAEARVKDIEKENKI 591
+++ ++ + + + E E L + L ++ + + + + K+I N++
Sbjct: 665 KQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQL 724
Query: 592 LHESIK---ETSSKLSKIEFEKRQI---KKELEHYKEKGERAEELENELHHLEKE----- 640
+ E K SS + + E+ Q+ KEL E + ++LE L E++
Sbjct: 725 IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY 784
Query: 641 ------NELLQKKITNLKITCE----KIEALEQENSELERENRKLKKTLDSFKNLTFQLE 690
+ LL ++I +L I + KIE L+ E +++ + + + TL ++L QL+
Sbjct: 785 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSE-QSTL--IRSLQSQLQ 841
Query: 691 SLEKENSQLDEENLELRRNVESLKCA-------SMKMAQLQLENK-ELESEKEQL-KKGL 741
+ E E + E + VE L A KM QL LE K ++E+ ++ + +K
Sbjct: 842 NKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQ 901
Query: 742 ELLKASFKKTER---LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
++ + SF TE+ L L +E + L++ L ++ + + ++++ + L++
Sbjct: 902 QVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQ 961
Query: 799 NLEEL----KISSKRLEQ----LEKENKSLEQETSQLEKDKKQLEKENKRLRQQ-AEIKD 849
N +E+ +IS + L+ L+KEN+ +++ ++K+L + RL ++ A +KD
Sbjct: 962 NYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKD 1021
Query: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCV--RLKELEKENKELVKRATIDIKTL-VT 906
+ +E + + E+ KE Y E CV + +E+E K+ + ++++ +
Sbjct: 1022 ESKKE--IPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD 1079
Query: 907 LREDLVSE---KLKTQQMNNDLEKLTHEL---------------------------EKIG 936
L E L +E + +QMN L+ T+++ + +
Sbjct: 1080 LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVA 1139
Query: 937 LNKERLLHDEQSTDDSRY--KLLESKLESTLKKSLEIK---EEKIAALEARLEESTNYNQ 991
L KE ++ T S + LE K+ + K+ +++ +E + + +A L+++ +
Sbjct: 1140 LVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKER 1199
Query: 992 QLRQELKTVKKNYEALKQRQDEER-------------MVQSSPPISGE-DNKWERESQET 1037
LR+ELK K +Y L+++ DE+ +Q I G+ + ++ES +
Sbjct: 1200 HLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSS 1259
Query: 1038 TRELLKVKDRLIEVERNNATLQA--------------------EKQALKTQLKQLETQNN 1077
T L + + E L++ +K QLK++E +
Sbjct: 1260 TPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKV 1319
Query: 1078 NLQAQILALQRQTVSLQEQNTTLQTQNAK--LQVENSTLNSQSTSLMNQNAQLLIQQSSL 1135
L+ ++ + + E+ LQ Q K L++E+ S + ++ Q ++ S L
Sbjct: 1320 ELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQL 1379
Query: 1136 ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGT--------LKSA 1187
+ ++E + LI E+ Q SE E+ ++K T +K+
Sbjct: 1380 QIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKAL 1439
Query: 1188 HKNLEVEHRDLEDRYNQL------LKQKGQLEDLEKMLKVE-QEKMLLENKNHETVAAEY 1240
H LE++ ++ ++R QL +KQK + E K + Q K+ + + E
Sbjct: 1440 HTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKEN 1499
Query: 1241 KKLCGENDRLNHTYSQLLK-----ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1295
K L E T +L K E++V +K ++L L L+ E KL +
Sbjct: 1500 KSLQEELSLARGTIERLTKSLADVESQV-SAQNKEKDTVLGRLAL----LQEERDKLITE 1554
Query: 1296 YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL----MLQNRTLLEQNMESKDL 1351
+ + + L++ CE L L E+ L+ +I++L + ++ E++ E +
Sbjct: 1555 MDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKE 1614
Query: 1352 FHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDIN 1411
+ + + Y + NE R + +E ++ + Y K+R +KK+
Sbjct: 1615 YEILLQSYENVSNEAERIQHVVEAVRQEKQELYG-------------KLRSTEANKKETE 1661
Query: 1412 RERQKS 1417
++ Q++
Sbjct: 1662 KQLQEA 1667
Score = 137 bits (344), Expect = 1e-31
Identities = 214/1031 (20%), Positives = 420/1031 (40%), Gaps = 197/1031 (19%)
Query: 159 HIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSE-E 217
H++E + + + EV + QE+++ + +A K + +D+ I E + E
Sbjct: 2154 HLEETIGEIQVTLNKKDKEVQQL-QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWE 2212
Query: 218 RDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDC 277
R + + + + + + RQ +S+ + + K I RL E +Q+ +
Sbjct: 2213 RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQ-MSIHMEELKINISRL-----EHDKQIWES 2266
Query: 278 KQELEQMEIELKR-----LQQENMNLLSDARSAR-MYRDELDALREKAVRVDKLESEVSR 331
K Q E++L++ LQ EN LLS R +Y + L KLESE+
Sbjct: 2267 KA---QTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA-------KLESELKS 2316
Query: 332 YKERLHDIEFYKARVEELKEDNQVLLETKT-----------MLEDQLEGTRARSDKLHE- 379
K++L D+ + +E K + + ++ + LE L+ +R + +LHE
Sbjct: 2317 LKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEE 2376
Query: 380 -----------LEKENLQLKAKLHDMEMERDMDRKKIEELM----EENMTLEMAQKQSMD 424
L + ++ + ++ + D + K++E L+ EEN+ LE K+++D
Sbjct: 2377 INMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVD 2436
Query: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR----------------------- 461
++ L L+ I + + +A S ++ L + R
Sbjct: 2437 KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQ 2496
Query: 462 -LLKLEMENQSLTKTVEELRTTVDSVEGNASKI-------------------------LK 495
+ + EN L + + LR+ +D + +K+ L+
Sbjct: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLE 2556
Query: 496 ME-KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE---R 551
++ ++N+ L K LE ++ + +++ ++ + L +EK L K IE+L+ + R
Sbjct: 2557 VQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTR 2616
Query: 552 QIKILEQE------NEHLNQTVSSLRQRSQI--SAEARVKDIEKENKILHESIKETSSKL 603
Q+ L++E + L + + S + S++ R+ ++E+E + KE + K+
Sbjct: 2617 QVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQ---KEAAKKV 2673
Query: 604 SKIEFEKRQIKKELEHY-------KEKGERAEE-----------LENELHHLEKENELLQ 645
+IE ++KKEL+H + + E AEE +E +L + KEN+ L
Sbjct: 2674 GEIE---DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLT 2730
Query: 646 KKITNLKITCEKIE-ALEQENSELERENRKLKKTLDSFKNLTFQ---------------- 688
+I + + ++ + + N EL+ RK +L L Q
Sbjct: 2731 AQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAF 2790
Query: 689 ---------LESLEKENSQL---DEENLELRRNVES----LKCASMKMAQLQLENKELES 732
L LEK N QL DE+ L L +E ++ S MA LQ E L +
Sbjct: 2791 SMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWN 2850
Query: 733 EKEQLKKGLELLKASFKK-------TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE 785
E E+ +K E + S + + L+ + L + RL K L+N ++ Q+ E
Sbjct: 2851 ELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE 2910
Query: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
+ +L LQ+ ++ K E+L +EN S + E QL +K E +R+++Q
Sbjct: 2911 ITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQY 2970
Query: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE-----NKELVKRATID 900
+ + ++ + NL +E ++ S + K R E ++ LV +
Sbjct: 2971 LMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELL 3030
Query: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGL----NKERLLHDEQSTDD--SRY 954
L +++ ++L+ QQ+N++ +L E + + + L ++Q D +
Sbjct: 3031 RTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHC 3090
Query: 955 KLLESKLESTLKKSLEIKEEKIAALE----------ARLEESTNYNQQLRQELKTVKKNY 1004
+LE +++ L I A E L E + +Q+L ++
Sbjct: 3091 AVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEV 3150
Query: 1005 EALKQRQDEER 1015
L++ +EER
Sbjct: 3151 NELRKLLEEER 3161
Score = 135 bits (341), Expect = 3e-31
Identities = 256/1297 (19%), Positives = 540/1297 (41%), Gaps = 196/1297 (15%)
Query: 133 VQCQKKEEFIE--------RIQGLDFDTKAAVAA---HIQEVTHNQENVFDLQWMEVTDM 181
VQ Q+K+E ++ +I+ L KA + + +I+E+ V + +
Sbjct: 73 VQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL 132
Query: 182 SQEDIEPLLKNMALH-LKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM 240
S+ D + M + +K + E++E T+ + Q+ P
Sbjct: 133 SKHDKSSTEEEMEIEKIKHKLQEKEELISTL---------------QAQLTQAQAEQPAQ 177
Query: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
TE + + ++Q+L+EK E + + +L Q + E Q
Sbjct: 178 SSTEMEEFVM------------MKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDAR 225
Query: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK-EDNQVLLET 359
R++ DEL L +A +E+E+ + K RV + K E+++ L
Sbjct: 226 FETQVRLHEDELLQLVTQA----DVETEMQQ-----------KLRVLQRKLEEHEESLVG 270
Query: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE------ELMEENM 413
+ + D L+ +L E+ N L +L ME E + R +E +++ E M
Sbjct: 271 RAQVVDLLQ------QELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKM 324
Query: 414 TLEMAQKQ-----SMDESLHLGWELEQISRTSELSEAPQKSLGH----EVNELTSSRLLK 464
LE+A+++ +E HL + EQ + E+ +L E+ E TS L
Sbjct: 325 ELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHIL-- 382
Query: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
SL KT +EL++ D+++ SK+L+ + E + VQ Q++Q
Sbjct: 383 ------SLQKTGQELQSACDALKDQNSKLLQDKNE-------------QAVQSAQTIQQL 423
Query: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
++ + KE +Q + + + Q + NE ++ + + S + RV +
Sbjct: 424 EDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNE----GTQAVTEENIASLQKRVVE 479
Query: 585 IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELL 644
+E E L S S +L +++ E ++ ++ E R E + E+ + ++
Sbjct: 480 LENEKGALLLS----SIELEELKAENEKLSSQIT-LLEAQNRTGEADREVSEISIV-DIA 533
Query: 645 QKKITNLKITCEKI--EALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE 702
K+ ++ + + + + Q++ EL ++K+ + L QL+ E + +
Sbjct: 534 NKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVL 593
Query: 703 NLELRRNVESLKCASMKMAQLQLENK----ELESEKEQLKKGLELLKASFKKTERL--EV 756
+ + + +E A +KM ++ LE+ L +E +E +AS + R E+
Sbjct: 594 DQKEMKQMEGEGIAPIKM-KVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEI 652
Query: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816
S +E L+ T ++ +K + + Q + E + L+ + EL+++ + +++ ++
Sbjct: 653 SLNDAGVE---LKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEK 709
Query: 817 NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIY 876
N L+++ ++ + +E+ K + EE + + + KE+ +
Sbjct: 710 N--LDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQV--------KELSMV 759
Query: 877 KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936
E ++K+LE E ++ +D ++ T ++L++E++ + + + + E+ +
Sbjct: 760 TELRAQVKQLEMNLAEAERQRRLDYES-QTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNE 818
Query: 937 LNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQE 996
L+ +L EQST + L+S+L++ + LE E++ + +++EE + Q +E
Sbjct: 819 LDDVQLQFSEQST---LIRSLQSQLQNKESEVLE-GAERVRHISSKVEELSQALSQ--KE 872
Query: 997 LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1056
L+ K + L++++D E + Q+ E + Q+ T + ++++++
Sbjct: 873 LEITKMDQLLLEKKRDVETLQQTI----------EEKDQQVTEISFSMTEKMVQLNEEKF 922
Query: 1057 TLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQ----EQNTTLQTQNAKLQVENS 1112
+L E + LK QL L + Q+ + L+ E + Q +LQ E
Sbjct: 923 SLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFD 982
Query: 1113 TLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK--SLYDSLIKDHEKLELLHERQ 1170
L ++ + LI + L + +E +LK S + + + E+ E+ +++
Sbjct: 983 LLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKE 1042
Query: 1171 ASEY-----------------ESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ-L 1212
EY +++ K L+ K+LE E E+++ L+KQ Q L
Sbjct: 1043 NKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLE-EKLAAEEQFQALVKQMNQTL 1101
Query: 1213 EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL-------- 1264
+D + LL+ + E A K + D + L+KET V+
Sbjct: 1102 QDKTNQID------LLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSS 1155
Query: 1265 -----QTDHKNLKSLLNNSKLEQTRLEAEFSK---LKEQYQQLDITSTKLNNQCELLSQL 1316
+ + K L +L++ EA S+ LK+ ++ +L Q + ++L
Sbjct: 1156 EHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRL 1215
Query: 1317 KGNLEE---ENRHLLDQIQTLMLQNRTLLEQNMESKD 1350
+ +E EN ++ DQ++ L +Q R ++ + S D
Sbjct: 1216 QEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTD 1252
Score = 101 bits (252), Expect = 6e-21
Identities = 191/916 (20%), Positives = 378/916 (41%), Gaps = 110/916 (12%)
Query: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ---T 566
L+ E+ QE N +D+ + A E+ + L++ ++ L+Q++E L +
Sbjct: 30 LDPELHQESDMEFN-NTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKA 88
Query: 567 VSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER 626
+ ++ ++ A+A++ + NK + E + + L + Q+ K H K E
Sbjct: 89 ADNKIKKLKLHAKAKLTSL---NKYIEEMKAQGGTVLPTEPQSEEQLSK---HDKSSTEE 142
Query: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELER---ENRKLKKTLDSFK 683
E+E H L+++ EL+ ++T + E Q ++E+E ++L++ +
Sbjct: 143 EMEIEKIKHKLQEKEELI--STLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFIS 200
Query: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL 743
L QL + E + + R ++ ++ QL + ++E+E +Q + L+
Sbjct: 201 TLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL-VTQADVETEMQQKLRVLQ- 258
Query: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL 803
+K E E S G LQ+ L + ++ Q L +LQ +E E+ TL+ +E
Sbjct: 259 -----RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETE 313
Query: 804 KISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLE 863
+ SK L LEK +E E ++ + L++E L +Q E E + LE
Sbjct: 314 REESKIL--LEK----MELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALE 367
Query: 864 KENKTLSKEIGIYKESCVRLKELEKENKELVKRATI----DIKTLVTLREDLVSEKLKTQ 919
+++K +E + L+K +EL + K L E V Q
Sbjct: 368 QKHK------AEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQ 421
Query: 920 QMNNDLEKLTHELEKIGLNKERLLHDEQST--------DDSRYKLLESKLESTLKKSLEI 971
Q+ + L++ + E+ + LN+ L E ++ ++ + E + S K+ +E+
Sbjct: 422 QLEDQLQQKSKEISQF-LNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVEL 480
Query: 972 KEEKIAAL--EARLEESTNYNQQLRQELKTVK-KNYEALKQRQDEERMV-------QSSP 1021
+ EK A L LEE N++L ++ ++ +N R+ E + SS
Sbjct: 481 ENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA 540
Query: 1022 PISGED---NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN 1078
SG+D N + ++ +E + LL++K+ E+ LQ ++ + +
Sbjct: 541 EESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQ 600
Query: 1079 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1138
++ + +A + V L++ N +S+ + Q + S +E
Sbjct: 601 MEGEGIAPIKMKVFLEDTGQDFPLMP----------NEESSLPAVEKEQASTEHQSRTSE 650
Query: 1139 NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLK-SAHKNLEVEHRD 1197
S+ +LKS K + + + E E L S+ L+ + HK E+ ++
Sbjct: 651 EISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKN 710
Query: 1198 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1257
L+++ ++ +E+ + KN + ++ + L E D+L +L
Sbjct: 711 LDEKAKEISNLNQLIEEFK--------------KNADNNSSAFTALSEERDQLLSQVKEL 756
Query: 1258 LKETEV---LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLS 1314
TE+ ++ NL +L+ A + L EQ L I + + + E+L
Sbjct: 757 SMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVL- 815
Query: 1315 QLKGNLEEENRHLLDQIQTLMLQNRTLLE------QNMESKDLFHVEQRQYI----DKLN 1364
++ LD +Q + TL+ QN ES+ L E+ ++I ++L+
Sbjct: 816 ----------QNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865
Query: 1365 ELRRQKEKLEEKIMDQ 1380
+ QKE LE MDQ
Sbjct: 866 QALSQKE-LEITKMDQ 880
Score = 67.8 bits (164), Expect = 9e-11
Identities = 100/472 (21%), Positives = 206/472 (43%), Gaps = 81/472 (17%)
Query: 919 QQMNNDLEKLTHELEKIGLN-------KERLLHDEQSTDDSRYKLLESKLESTLKKSLEI 971
Q M L+ H+ + N +ERL + EQ L +L+ +++
Sbjct: 24 QNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQ---------LVVELKDIIRQKDVQ 74
Query: 972 KEEKIAALEARLEESTNYNQQLR----QELKTVKKNYEALKQRQDEERMVQSSPPISGED 1027
++K AL+ + + N ++L+ +L ++ K E +K + ++ + P +
Sbjct: 75 LQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGT--VLPTEPQSEEQL 132
Query: 1028 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1087
+K ++ S E E+ K+K +L E E +TLQA Q + Q +Q Q++ + + ++
Sbjct: 133 SKHDKSSTEEEMEIEKIKHKLQEKEELISTLQA--QLTQAQAEQ-PAQSSTEMEEFVMMK 189
Query: 1088 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1147
+Q +E +TLQ Q + Q+ E + V++E++
Sbjct: 190 QQLQEKEEFISTLQAQ--------------------------LSQTQAEQAAQQVVREKD 223
Query: 1148 DLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLK 1207
+ +++ ++ HE E L+++ + L V R LE+ + + L
Sbjct: 224 ---ARFETQVRLHE----------DELLQLVTQADVETEMQQKLRVLQRKLEE-HEESLV 269
Query: 1208 QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD 1267
+ Q+ DL ++QE E +N + ++ + +++ E++ L +T +E+++L
Sbjct: 270 GRAQVVDL-----LQQELTAAEQRN-QILSQQLQQMEAEHNTLRNTVETEREESKILL-- 321
Query: 1268 HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL-KGNLEEENRH 1326
+ ++ + KL L+ E L EQ++Q +L ++ L Q K +EE+ H
Sbjct: 322 -EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 380
Query: 1327 LLDQIQT---LMLQNRTLLEQN---MESKDLFHVEQRQYIDKLNELRRQKEK 1372
+L +T L L +QN ++ K+ V+ Q I +L + +QK K
Sbjct: 381 ILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSK 432
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 189 bits (480), Expect = 2e-47
Identities = 252/1122 (22%), Positives = 486/1122 (43%), Gaps = 126/1122 (11%)
Query: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE-QMEIELKRL-------- 291
K S + L +A K R+ELEEK LL K +L+ Q++ E L
Sbjct: 847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCD 906
Query: 292 QQENMNLLSDARSARM---YRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEE 348
Q + +A+ M DE + E + KLE E S K + D+E A+VE+
Sbjct: 907 QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK 966
Query: 349 LKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAK----LHDMEMERDMDRKK 404
K T+ +++ E + + +L KE L+ L D++ E D K
Sbjct: 967 EKH------ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED----K 1016
Query: 405 IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
+ L + + LE Q +D+ L LEQ + E ++ L ++ +LT ++
Sbjct: 1017 VNTLTKAKVKLE----QQVDD---LEGSLEQEKKVRMDLERAKRKLEGDL-KLTQESIMD 1068
Query: 465 LEMENQSLTKTVE----ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520
LE + Q L + ++ EL +E + +++K+ + L ++E LE E+ E+ +
Sbjct: 1069 LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTA 1128
Query: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
+ L DL +E ++ + +E + QI++ ++ + L + + + EA
Sbjct: 1129 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEAT-LQHEA 1187
Query: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
+ K++ +S+ E ++ ++ ++K++LE KEK E EL++ ++E+
Sbjct: 1188 TAAALRKKHA---DSVAELGEQIDNLQ----RVKQKLE--KEKSEFKLELDDVTSNMEQ- 1237
Query: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLD 700
+ K NL+ C +E ++ K ++T S +LT Q L+ EN +L
Sbjct: 1238 ---IIKAKANLEKMCRTLE------DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELS 1288
Query: 701 EENLELRRNVESLKCASMKMAQLQLEN--KELESEKEQLKKGLELLKASFKKTERLEVSY 758
+ E + L + Q QLE+ ++LE E + L+++ + L Y
Sbjct: 1289 RQLDEKEALISQLTRGKLTYTQ-QLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQY 1347
Query: 759 QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLEKEN 817
+ LQ+ L +N ++ Q ++ + ++ + LEE K ++RL++ E+
Sbjct: 1348 EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT---EELEEAKKKLAQRLQEAEEAV 1404
Query: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL---------------------EENN 856
+++ + S LEK K +L+ E + L E + EE+
Sbjct: 1405 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQ 1464
Query: 857 VKIGNLEKENKTLSKEI----GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV 912
++ + +KE ++LS E+ Y+ES L+ ++ENK L + + DL
Sbjct: 1465 SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS-----------DLT 1513
Query: 913 SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD-EQSTDDSRYKLLESKLESTLKKSLEI 971
+ + + ++LEK+ +LE + + L + E S + K+L ++LE K+ EI
Sbjct: 1514 EQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA-EI 1572
Query: 972 KEEKIAALEARLEESTNYNQQLRQELKT-----VKKNYEALKQRQDEERMVQSSPPISGE 1026
E K+A + +E++ + ++ L+T + EAL+ ++ E +
Sbjct: 1573 -ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSH 1631
Query: 1027 DNKWERESQETTRELLKV-KDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1085
N+ E+Q+ + L + KD I+++ ++A LK + +E +NN LQA++
Sbjct: 1632 ANRMAAEAQKQVKSLQSLLKDTQIQLDD---AVRANDD-LKENIAIVERRNNLLQAELEE 1687
Query: 1086 LQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1145
L+ + + + + L+SQ+TSL+NQ ++ S L+ E E ++E
Sbjct: 1688 LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Query: 1146 REDLKSLYDSLIKDHEKL--ELLHERQASEYESLISKH--GTLKSAHKNL-EVEHRDLED 1200
+ + I D + EL E+ S + + K+ T+K L E E L+
Sbjct: 1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG 1807
Query: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC--GENDRLNHTYSQLL 1258
QL K + ++ +LE L+ EQ++ K K+L E DR N LL
Sbjct: 1808 GKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKN-----LL 1862
Query: 1259 KETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD 1300
+ +++ +K+ ++ + + SK ++ +LD
Sbjct: 1863 RLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1904
Score = 152 bits (383), Expect = 4e-36
Identities = 206/972 (21%), Positives = 415/972 (42%), Gaps = 103/972 (10%)
Query: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSL 521
LLK + + EE +++E + ++ ++E++ L ++ L+ ++ E+ +L
Sbjct: 839 LLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNL 898
Query: 522 QNCQNLSKDLMKEKAQLEKTIETLRENSERQIKI---LEQENEHLNQTVSSLRQRSQISA 578
+ + L+K K QLE ++ + E E + ++ L + L S L+ R
Sbjct: 899 ADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELK-RDIDDL 957
Query: 579 EARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA----EELENEL 634
E + +EKE +K + +++ ++ ++ KE + +E ++A + E+++
Sbjct: 958 ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 635 HHLEKENELLQKKITNLKITCEKIEALEQENS---ELERENRKLKKTLDSFKNLTFQLES 691
+ L K L++++ +L+ +LEQE +LER RKL+ L K +
Sbjct: 1018 NTLTKAKVKLEQQVDDLE------GSLEQEKKVRMDLERAKRKLEGDL---KLTQESIMD 1068
Query: 692 LEKENSQLDE----ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKAS 747
LE + QLDE ++ EL ++ +QLQ + KEL++ E+L++ LE + +
Sbjct: 1069 LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTA 1128
Query: 748 FKKTERLEVSY-QGLDIENQRLQKTLENSNKKIQ---QLESELQDL--EMENQTLQKNLE 801
K E+L + L+ ++RL++ ++ +I+ + E+E Q + ++E TLQ
Sbjct: 1129 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEAT 1188
Query: 802 ELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861
+ K + + + L ++ L++ K++LEKE + + + + +E+ N
Sbjct: 1189 AAALRKKHADSVAE----LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1244
Query: 862 LEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQM 921
LEK +TL ++ ++ E +R+ DL S++ K Q
Sbjct: 1245 LEKMCRTLEDQMNEHRSKA-----------EETQRSV----------NDLTSQRAKLQTE 1283
Query: 922 NNDLEKLTHELEKI--GLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAAL 979
N +L + E E + L + +L + +Q D R E K ++ L +L+ L
Sbjct: 1284 NGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLL 1343
Query: 980 EARLEESTNYNQQLRQELKTVKKNYEALKQRQDEER-MVQSSPPISGEDNKWERESQETT 1038
+ EE T +L++ L K N E + R E +Q + + K + QE
Sbjct: 1344 REQYEEETEAKAELQRVLS--KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1401
Query: 1039 RELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNT 1098
+ V + +E+ LQ E + L +++ L + + +++
Sbjct: 1402 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1461
Query: 1099 TLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK 1158
Q++ Q E +L+++ L N + L + + EN+++ +E DL S K
Sbjct: 1462 ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGK 1521
Query: 1159 DHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDL---EDRYNQLLKQKGQLEDL 1215
+LE + ++ +E L S L+ A +LE E + + +NQ+ + +
Sbjct: 1522 TIHELEKVRKQLEAEKMELQS---ALEEAEASLEHEEGKILRAQLEFNQIKAE------I 1572
Query: 1216 EKMLKVEQEKMLLENKNHETVAAEY------------------KKLCGENDRLNHTYSQL 1257
E+ L + E+M +NH V KK+ G+ + + S
Sbjct: 1573 ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHA 1632
Query: 1258 LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLK 1317
+ Q K+L+SLL +++++ LKE ++ + L + L +L+
Sbjct: 1633 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAE---LEELR 1689
Query: 1318 GNLE--EENRHLLDQ--------IQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELR 1367
+E E +R L +Q +Q L QN +L+ Q + Q + + + E R
Sbjct: 1690 AVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECR 1749
Query: 1368 RQKEKLEEKIMD 1379
+EK ++ I D
Sbjct: 1750 NAEEKAKKAITD 1761
Score = 122 bits (307), Expect = 2e-27
Identities = 169/788 (21%), Positives = 325/788 (41%), Gaps = 73/788 (9%)
Query: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664
K+ F+ + + K E KE EE LEK +E +K++ EK+ +L QE
Sbjct: 831 KLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEK-SEARRKELE------EKMVSLLQE 883
Query: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ 724
++L+ + ++ D+ + + + L K QL+ + E+ E L+ A+L
Sbjct: 884 KNDLQLQ---VQAEQDNLADAEERCDQLIKNKIQLEAKVKEMN---ERLEDEEEMNAELT 937
Query: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
+ ++LE E +LK+ ++ L+ + K E+ E + ++N +++ L+
Sbjct: 938 AKKRKLEDECSELKRDIDDLELTLAKVEK----------EKHATENKVKNLTEEMAGLDE 987
Query: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
+ L E + LQ + + L+ L+ E E + + L K K +LE QQ
Sbjct: 988 IIAKLTKEKKALQ------EAHQQALDDLQAE----EDKVNTLTKAKVKLE-------QQ 1030
Query: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
+ + +LE+ +LE+ + L ++ + +ES + L+ +++ E +K+ ++ L
Sbjct: 1031 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 905 VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST 964
ED E+ Q+ L++L +E++ +E L + + T ++ + L S L
Sbjct: 1091 NARIED---EQALGSQLQKKLKELQARIEEL---EEEL--EAERTARAKVEKLRSDLSRE 1142
Query: 965 LKKSLEIKEEKIAALEARLEESTNYN---QQLRQELKTVKKNYEALKQRQDEERMVQSSP 1021
L++ E EE A ++E + Q++R++L+ +EA ++ S
Sbjct: 1143 LEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL-RKKHADSVA 1201
Query: 1022 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA 1081
+ + + +R Q+ +E + K L +V N + K L+ + LE Q N ++
Sbjct: 1202 ELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRS 1261
Query: 1082 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES 1141
+ QR L Q LQT+N +L + + + L Q L+ + E
Sbjct: 1262 KAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEE 1321
Query: 1142 VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR 1201
+K + L S D +LL E+ E E+ L A+ + E
Sbjct: 1322 EVKAKNALAHALQSARHD---CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD 1378
Query: 1202 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET 1261
Q + E+LE+ K +++ + E V A+ L RL + L+ +
Sbjct: 1379 AIQ------RTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1432
Query: 1262 E-------VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLS 1314
E L +N +L K + ++E +++ + L KL N E
Sbjct: 1433 ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESL 1492
Query: 1315 QLKGNLEEENRHLLDQIQTLMLQ----NRTLLEQNMESKDLFHVEQRQYIDKLNELRRQK 1370
+ + EN++L ++I L Q +T+ E K L E+ + L E
Sbjct: 1493 EHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQL-EAEKMELQSALEEAEASL 1551
Query: 1371 EKLEEKIM 1378
E E KI+
Sbjct: 1552 EHEEGKIL 1559
Score = 122 bits (305), Expect = 4e-27
Identities = 152/680 (22%), Positives = 300/680 (44%), Gaps = 68/680 (10%)
Query: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787
KE+ S KE+ + E L+ S + + LE L E LQ ++Q + L
Sbjct: 847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL-------QVQAEQDNLA 899
Query: 788 DLEMENQTLQKNLEELKISSKRL-EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
D E L KN +L+ K + E+LE E E+ ++L K++LE E L++ +
Sbjct: 900 DAEERCDQLIKNKIQLEAKVKEMNERLEDE----EEMNAELTAKKRKLEDECSELKRDID 955
Query: 847 IKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVT 906
+ TL + + E + K L++E+ E +L + +K +E ++A D++
Sbjct: 956 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED 1015
Query: 907 LREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER----LLHDEQSTDDSRYKLLESKLE 962
L K+K +Q +DLE + +K+ ++ ER L D + T +S L K +
Sbjct: 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ 1075
Query: 963 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1022
L + L+ K+ ++ AL AR+E+ QL+++LK ++ E L++ + ER ++
Sbjct: 1076 --LDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARA--- 1130
Query: 1023 ISGEDNKWERESQETTRELLKVKDRL--------IEVERNNATLQAEKQALKTQLKQLET 1074
K E+ + +REL ++ +RL +++E N +AE Q ++ L++
Sbjct: 1131 ------KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR-EAEFQKMRRDLEEATL 1183
Query: 1075 QNNNLQAQILALQRQTVS-LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS 1133
Q+ A + +V+ L EQ LQ KL+ E S + + + Q++ ++
Sbjct: 1184 QHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1243
Query: 1134 SLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEV 1193
+LE + ++L D + + K E E Q S L S+ L++ + L
Sbjct: 1244 NLE----------KMCRTLEDQMNEHRSKAE---ETQRS-VNDLTSQRAKLQTENGELSR 1289
Query: 1194 EHRDLEDRYNQLLKQK----GQLEDLEKMLKVEQEKM-----LLENKNH--ETVAAEYKK 1242
+ + E +QL + K QLEDL++ L+ E + L++ H + + +Y++
Sbjct: 1290 QLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEE 1349
Query: 1243 LCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT 1302
L S+ E +T ++ ++ +LE+ + KL ++ Q+ +
Sbjct: 1350 ETEAKAELQRVLSKANSEVAQWRTKYET-DAIQRTEELEEAK-----KKLAQRLQEAEEA 1403
Query: 1303 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1362
+N +C L + K L+ E L+ ++ L ++ + +++Y +
Sbjct: 1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEES 1463
Query: 1363 LNELRRQKEKLEEKIMDQYK 1382
+EL +++ + +K
Sbjct: 1464 QSELESSQKEARSLSTELFK 1483
Score = 73.6 bits (179), Expect = 2e-12
Identities = 134/708 (18%), Positives = 300/708 (42%), Gaps = 77/708 (10%)
Query: 823 ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVR 882
++++ EK+ +++E RL++ E + +E K+ +L +E L ++ +++
Sbjct: 841 KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDN--- 897
Query: 883 LKELEKENKELVKRATIDIKTLVTLREDLVSEK-------LKTQQMNNDLEKLTHELEKI 935
L + E+ +L+K + + E L E+ K +++ ++ +L +++ +
Sbjct: 898 LADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDL 957
Query: 936 GLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQ 995
L ++ ++ +T +++ K L ++ + ++ +EK A EA +++ + Q
Sbjct: 958 ELTLAKVEKEKHAT-ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH-QQALDDLQAEED 1015
Query: 996 ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055
++ T+ K L+Q+ D+ + G + ++ + R K++ L + +
Sbjct: 1016 KVNTLTKAKVKLEQQVDD---------LEGSLEQEKKVRMDLERAKRKLEGDLKLTQESI 1066
Query: 1056 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1115
L+ +KQ L +LK+ + + N L A+I Q LQ++ LQ + +L+ E L
Sbjct: 1067 MDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEE---LE 1123
Query: 1116 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1175
++ T+ A++ +S L E E + + E+ I+ ++K E ++ + E
Sbjct: 1124 AERTA----RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLE 1179
Query: 1176 SLISKHGTLKSAHKNLEVEH-RDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE 1234
+H +A + + +L ++ + L + K +LE + K+E + + +
Sbjct: 1180 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1239
Query: 1235 TVAAEYKKLCGE-NDRLN----------HTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1283
A +K+C D++N + + L + LQT++ L L+ E+
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLD----EKE 1295
Query: 1284 RLEAEFSKLKEQY-QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQ----- 1337
L ++ ++ K Y QQL+ +L + + + L L+ RH D ++ +
Sbjct: 1296 ALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSA-RHDCDLLREQYEEETEAK 1354
Query: 1338 ---NRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGN 1394
R L + N E + I + EL K+KL +++ + + +
Sbjct: 1355 AELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEA-------- 1406
Query: 1395 WITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPH-----------QDSQDSS 1443
+ K L K+K + E + L + RS+++ L Q ++S
Sbjct: 1407 -VNAKCSSLEKTKHRLQNEIE-DLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQ 1464
Query: 1444 SVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEVPDDIS 1491
S +S ++ ++L T+ N +S L T EN + ++IS
Sbjct: 1465 SELESSQKEARSLSTELFKLKNAYEES--LEHLETFKRENKNLQEEIS 1510
Score = 70.1 bits (170), Expect = 2e-11
Identities = 101/516 (19%), Positives = 208/516 (40%), Gaps = 73/516 (14%)
Query: 950 DDSRYKLLESKL---ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1006
D ++YK +K+ L E+++E+++ + R++ Q R L + Y+
Sbjct: 752 DHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQA------QSRGVL--ARMEYKK 803
Query: 1007 LKQRQDEERMVQ-SSPPISGEDN-KWER---------ESQETTRELLKVKDRLIEVERNN 1055
L +R+D ++Q + G N W + +S E +E+ +K+ ++
Sbjct: 804 LLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKEEFTRLKEAL 863
Query: 1056 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1115
+A ++ L+ ++ L + N+LQ Q+ A Q +E+ L +L+ + +N
Sbjct: 864 EKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMN 923
Query: 1116 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK------------------------- 1150
+ NA+L ++ LE+E + ++ +DL+
Sbjct: 924 ERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMA 983
Query: 1151 ---SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLK 1207
+ L K+ + L+ H++ + ++ K TL A LE + DLE Q K
Sbjct: 984 GLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKK 1043
Query: 1208 QKGQLE----DLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY-------SQ 1256
+ LE LE LK+ QE ++ + + + KK E + LN SQ
Sbjct: 1044 VRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQ 1103
Query: 1257 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL 1316
L K+ + LQ + L+ L + + ++E S L + +++ + + ++
Sbjct: 1104 LQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEM 1163
Query: 1317 KGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
E E + + ++ LQ+ + E + ID L ++++ EK EK
Sbjct: 1164 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEK--EK 1221
Query: 1377 IMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINR 1412
+ + D +T M ++IK+K ++ +
Sbjct: 1222 SEFKLELDD----------VTSNMEQIIKAKANLEK 1247
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 186 bits (471), Expect = 2e-46
Identities = 274/1369 (20%), Positives = 576/1369 (42%), Gaps = 230/1369 (16%)
Query: 196 HLKRLIDERDEHSETIIELSEERDGL-HFLPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
H ++L + H E + + E + L + L S S + ++ Q L +E
Sbjct: 243 HQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKV 302
Query: 255 DAKAKIRRLRQELEEKTEQLLDC-------KQELEQMEIELKRLQQENMNL---LSDARS 304
++ K+ +L ++++ ++L ++E EQ+ +E +++ +E NL S +
Sbjct: 303 ESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQP 362
Query: 305 ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN----------- 353
+ + + + +E+ + EV R ++ L D E R+ L +DN
Sbjct: 363 SAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKM 422
Query: 354 --QVLLETKTMLEDQLEGTRARSDKL---HELEKE----NLQLKAKLHDMEMERDMDRKK 404
+VL + K++L + E + KL +E+ K ++ L ++LHD+ + + ++
Sbjct: 423 RIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQE 482
Query: 405 IEELMEENMTL----EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
+ + + E TL E +Q+ + + H+ +Q+S+ ++ L ++N+
Sbjct: 483 LNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLND-EKK 541
Query: 461 RLLKLEMENQSLTKTVEELRTTV------------------DSVEGNASKILKMEKENQR 502
R+ +LE + +TK ++ + + D VE ++ K ++ N
Sbjct: 542 RVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVS 601
Query: 503 LSKKVEILENEIVQEKQSLQNCQN-LSKDLMKEK-AQLEKTIETLRENSERQIKILEQEN 560
+ K+ L+ I Q ++ L +N L + L ++ + + T+ RE R +K E
Sbjct: 602 IQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661
Query: 561 EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK-------ETSSKLSKIEFEKRQI 613
E LN+ + + ++ E V E L E + E ++ + ++ EK +I
Sbjct: 662 EQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
Query: 614 KKEL--------EHYKEKGERAEELEN-----------ELHHLEKENELLQKKITNLKIT 654
+ EL E + + EEL N E HL K N+ +I LK
Sbjct: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKN 781
Query: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEE----NLELRRN 709
E+++ +E ++ + + +K L N +E L++ +S+L EE + LR+N
Sbjct: 782 IEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKN 841
Query: 710 V---ESLKCASMKMAQLQLENKELESEKEQLK------------KGLELLKASFKKTERL 754
++++ + ++ EN L+ E E+L+ K L+ + + +L
Sbjct: 842 EILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQL 901
Query: 755 EVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL---- 810
+ L+ E + QK +E+ N+ QL LQ+ + E + E++ + +L
Sbjct: 902 NTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEK 961
Query: 811 -EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
E+++ K++EQ +QL ++++ ++ +N + Q+ +++ +E + K + E + L
Sbjct: 962 DEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERL 1021
Query: 870 SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEK-LKTQQMNNDLEKL 928
K I KE + +K L ++N L K+ K V ++ +K L+ Q ++ +
Sbjct: 1022 VKGI---KERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISST 1078
Query: 929 THELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 988
+H T D Y L+ L+ +E+ A L + E+++
Sbjct: 1079 SH------------------TQDVVY------LQQQLQAYAMEREKVFAVLNEKTRENSH 1114
Query: 989 YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKD-- 1046
+ + + V AL + QDE + + + SG+D RE+ + +++ KD
Sbjct: 1115 LKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQD--MFRETIQNLSRIIREKDIE 1172
Query: 1047 ---------RLIEVERNNAT--------------LQAEKQALKTQLKQLETQNNNLQAQI 1083
L+ V + ++T L E+ LK Q+K++E + +
Sbjct: 1173 IDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTV 1232
Query: 1084 LALQRQTVSLQEQNTTLQTQ-------NAKLQVENSTL----NSQSTSLMNQNAQLLIQQ 1132
+Q ++ LQE+ LQ Q N+KLQV+ + L T L N +L Q
Sbjct: 1233 QNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQ 1292
Query: 1133 SS---------------------LENENESVIKEREDLKSLYDSLIKDHEKLELLHERQA 1171
S L + + + E L++ ++ E ELL +
Sbjct: 1293 HSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLS--ESSELLQQELE 1350
Query: 1172 SEYESLISKHGTLKSAHKN-----------LEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1220
+SL K T+++ +N E+E ++ E +++ + K + + L+K+LK
Sbjct: 1351 ELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLK 1410
Query: 1221 VEQEKMLLENKNHETVAA--EYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNS 1278
++ +L++ K+ + +++ + EN+ L + L + +L+ D LK N
Sbjct: 1411 --EKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKG--ENE 1466
Query: 1279 KLEQT--RLEAEFSKLKEQYQQLDITSTKLNNQC-----------ELLSQLKGNLEEENR 1325
K+ +T E E+ L+E + + + +C +LL + + E
Sbjct: 1467 KIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELN 1526
Query: 1326 HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL--NELRRQKEK 1372
LL+ +++ +Q +T++ Q + + ++Q+Q + NE++R ++K
Sbjct: 1527 QLLNAVKS--MQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDK 1573
Score = 159 bits (402), Expect = 2e-38
Identities = 296/1382 (21%), Positives = 569/1382 (41%), Gaps = 228/1382 (16%)
Query: 155 AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL 214
A +A ++EV Q+ + D + E+ +S + + L L LK I+ ++ L
Sbjct: 379 AQSASVEEVFRLQQALSDAE-NEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL---L 434
Query: 215 SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQ-HLSVELADAKAKIRRLRQELEEKTEQ 273
S+E++ L ++ +K T +R L EL D LR LE K ++
Sbjct: 435 SQEKEELQMSLLKLNNEYEV-----IKSTATRDISLDSELHD-------LRLNLEAKEQE 482
Query: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-DKLESEVSRY 332
L E E + E++ L ++N + + +D+L + + + KL+ +++
Sbjct: 483 LNQSISEKETLIAEIEELDRQNQEA---TKHMILIKDQLSKQQNEGDSIISKLKQDLNDE 539
Query: 333 KERLHDIEFYKARV-EELKEDNQVLLE----------TKTMLEDQLEGTRARSDKLHE-- 379
K+R+H +E K + +EL + L++ TK LED++E + +K E
Sbjct: 540 KKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESN 599
Query: 380 --LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS 437
++KENL+LK + E E R ELM+ +L + ++L E E +
Sbjct: 600 VSIQKENLELKEHIRQNEEELSRIRN---ELMQ---SLNQDSNSNFKDTLLKEREAEVRN 653
Query: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD---------SVEG 488
LSE Q +NE ++MEN+ L E++R ++ S+E
Sbjct: 654 LKQNLSELEQ------LNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEK 707
Query: 489 NAS-KILKMEK---ENQRLSKKVEILENEIVQEK--QSLQNCQNLSKDLMK--------- 533
N + LKMEK E + K +LE EK + L N +NL+ ++
Sbjct: 708 NTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKL 767
Query: 534 ------EKAQLEKTIETLRENSERQIKILE---QENEHLNQTVSS-------LRQRSQIS 577
E A+L+K IE + + + +L +E + L Q ++ L++RS
Sbjct: 768 NQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKL 827
Query: 578 AEARVKDIE--KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE------- 628
E K + ++N+IL ++I+E L ++ E +++ELE +E+ R
Sbjct: 828 QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKT 887
Query: 629 -----ELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683
EL +E+ L E L+++I + + + IE Q +L + ++ KK +D F+
Sbjct: 888 LDSVTELASEVSQLNTIKEHLEEEIKHHQ---KIIEDQNQSKMQLLQSLQEQKKEMDEFR 944
Query: 684 NLTFQLESLEKENSQL----DEENLELRRNVESLKCASMKMAQ-LQLENKELESEKE--- 735
+Q E + ++QL DEE L++ +E +K + Q +Q +N ++ E +
Sbjct: 945 ---YQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQS 1001
Query: 736 -QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE--------L 786
++ G E S +TERL + ++E + L + + K+I QL + +
Sbjct: 1002 LNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQII 1061
Query: 787 QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Q ++E Q L + ++ + L+++ ++ E ++ + +EN L+ +
Sbjct: 1062 QQKDLEIQALHARISSTS-HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH 1120
Query: 847 IKDTTLEENNVKIGNLEKENKTLSKEI-----GIYKESCVRLKELEKENKELVKRATIDI 901
+ + L+ ENK LS +++E+ L + +E + +
Sbjct: 1121 KMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC 1180
Query: 902 KTLVTLR-----------------EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944
+TL+ + E+L+ E+ K +Q ++K+ +++ + + H
Sbjct: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQ---VKKMEEWKQQVMTTVQNMQH 1237
Query: 945 DEQSTDDSRYKLL---------ESKLE---STLKKSLEIKEEKI-------AALEARLEE 985
+ + ++L SKL+ + L +S E E K+ A ++ + +
Sbjct: 1238 ESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ 1297
Query: 986 STNYNQQLRQELKTVKKNYEA--LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLK 1043
N L +L + + L Q E + S + E ++ ++ E R+ L+
Sbjct: 1298 LCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQ 1357
Query: 1044 VKDRLIE-VERNNATL-----------QAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1091
KD I ++ NN L + E + +++KQL+ + + LQ ++L + +
Sbjct: 1358 EKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQ-KLLKEKDLLI 1416
Query: 1092 SLQEQNTTLQTQNAKLQV-ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1150
+ +N +V EN L T+L + L + L+ ENE +++ +
Sbjct: 1417 KAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKE 1476
Query: 1151 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK- 1209
+ Y +L + + K ++ + E S+ ++ + QLLK+K
Sbjct: 1477 TEYQALQETNMKFSMMLREKEFECHSM------------------KEKALAFEQLLKEKE 1518
Query: 1210 ----GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ 1265
G+L L +K QEK ++ + + V K+ EN L + EV +
Sbjct: 1519 QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTAL---------QNEVQR 1569
Query: 1266 TDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ----LKGNLE 1321
K +S +L LE+E S +E D KL + +L + +E
Sbjct: 1570 LRDKEFRSNQELERLRNHLLESEDSYTREALAAED-REAKLRKKVTVLEEKLVSSSNAME 1628
Query: 1322 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQ---RQYIDKLNELRRQKE--KLEEK 1376
+ Q+++L Q + +Q E+ V Q +QY L L+ E + EEK
Sbjct: 1629 NASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEK 1688
Query: 1377 IM 1378
M
Sbjct: 1689 AM 1690
Score = 156 bits (394), Expect = 2e-37
Identities = 266/1233 (21%), Positives = 521/1233 (42%), Gaps = 198/1233 (16%)
Query: 355 VLLETKTMLEDQLEGTRARS-DKLHE-LEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412
+L+E +E +L +R + + +H L EN +LK D+E + + +I++ ++
Sbjct: 37 MLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQ---QS 93
Query: 413 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
+ +Q E HL + QI+ +L + L + S + + S
Sbjct: 94 TSYRNQLQQKEVEISHL--KARQIALQDQLLK-----LQSAAQSVPSGAGVPATTASSSF 146
Query: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQ--NCQNLSKD 530
+ + + + I+ ++E RLS +V LE+E+ + Q Q
Sbjct: 147 AYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNS 206
Query: 531 LMKEKAQLEKTIETLRENSERQIKILEQE-----NEHLNQ-TVSSLRQRSQIS-AEARVK 583
E +L+ I+ L++N ++I + E N H + T S R R ++S E R++
Sbjct: 207 DQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIE 266
Query: 584 DIEK----------ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----GERAEE 629
++E E + I E + ++ EK + K++E ++K ++
Sbjct: 267 ELENLLQQGGSGVIETDL--SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSS 324
Query: 630 LENELHHLEKENELL-------QKKITNLKITCEKIE--ALEQENSELEREN-------- 672
EN+ L +E E L ++ NLK+ C K++ A++Q ++ E+E
Sbjct: 325 AENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASV 384
Query: 673 ---RKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729
+L++ L +N +L SL ++NS L E+NL+L+ +E L+ ++Q E +E
Sbjct: 385 EEVFRLQQALSDAENEIMRLSSLNQDNS-LAEDNLKLKMRIEVLEKEKSLLSQ---EKEE 440
Query: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
L+ +L E++K++ + L+ L + + ++ L S + + L +E+++L
Sbjct: 441 LQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEEL 500
Query: 790 EMENQTLQKNLEELKISSKR--------LEQLEKENKSLEQETSQLEKDKKQLEKE---- 837
+ +NQ K++ +K + + +L+++ ++ QLE DK + KE
Sbjct: 501 DRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQ 560
Query: 838 -NKRLRQQAEIKDTTLEENNV--KIGNL-EKENKTLSKEIGIYKESCVRLKELEKENKEL 893
K ++ + + D L + + K+ NL ++ NK+ + I KE+ + LKE ++N+E
Sbjct: 561 KEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKEN-LELKEHIRQNEEE 619
Query: 894 VKRATIDI-------------KTLVTLRE----DLVSEKLKTQQMNNDLEKLTHEL---- 932
+ R ++ TL+ RE +L + +Q+N +L+K+ ++
Sbjct: 620 LSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMEN 679
Query: 933 EKIGLNKERLLH--DEQSTDDSRYKLLESKLESTLK-KSLEIKEEKIAALEARLEESTNY 989
EK+ L E + H +E +++ L ++ + TLK + EI+ E A + LEE+ Y
Sbjct: 680 EKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKY 739
Query: 990 ----------------------------NQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1021
NQ+ E+ +KKN E + E + V SS
Sbjct: 740 EKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSS- 798
Query: 1022 PISGEDNKWERESQETTRELLKVKDRLIE-VERNNATLQAEKQALKTQLKQLETQNNNLQ 1080
E Q+ +L+ K+ IE ++ ++ LQ E L+ +N L+
Sbjct: 799 ---------SLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALR----KNEILR 845
Query: 1081 AQILALQRQTVSLQEQNTTLQTQNAKLQVENS---------TLNSQSTSLMNQNAQLLIQ 1131
I R S++E+N LQ + +L+ E S TL+S T L ++ +QL
Sbjct: 846 QTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDS-VTELASEVSQLNTI 904
Query: 1132 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH--ERQASEYESLISKHGTLKSAHK 1189
+ LE E + K ED ++ K++LL + Q E + +H + + H
Sbjct: 905 KEHLEEEIKHHQKIIED---------QNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHT 955
Query: 1190 NLEVEHRDLEDRYNQLLKQ-KGQLEDLEKMLKVEQEKMLLENK----NHETVAAEYKKLC 1244
L +E + + ++Q K QL + + ++ + + E K N E + ++
Sbjct: 956 QLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSK 1015
Query: 1245 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1304
E +RL + +E E+ + KN+ +L + E KL + QQ D+
Sbjct: 1016 AETERLVKGIKE--RELEIKLLNEKNISLTKQIDQLSKD----EVGKLTQIIQQKDLEIQ 1069
Query: 1305 KLNNQCELLSQLKGNLEEENRHLLDQIQT-LMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1363
L+ + S ++ +L Q+Q M + + N ++++ H++ + K+
Sbjct: 1070 ALHARISSTSH-----TQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH--KM 1122
Query: 1364 NELRRQKEKLEEKIMDQYKFYD---PSPPRRRGNWITLKMRKLIKSKK-DINRERQKSLT 1419
++ KE K+ D+ K S + + ++I+ K +I+ QK T
Sbjct: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQT 1182
Query: 1420 LTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLED 1452
L SS G ++ V SN E+
Sbjct: 1183 LLAVLQTSSTG---------NEAGGVNSNQFEE 1206
Score = 150 bits (380), Expect = 8e-36
Identities = 227/1000 (22%), Positives = 428/1000 (42%), Gaps = 148/1000 (14%)
Query: 579 EARVKDIEKENKIL---HESIKETSSKLS-KIEFEKRQIKKELEHYKEKGERAEELENEL 634
++R K+IE + IL +E +K+ + L K E + QIK++ Y+ + ++ E E+
Sbjct: 51 DSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQ---LQQKEVEI 107
Query: 635 HHLEKENELLQKKITNLKITCEKIEA---------------------------------- 660
HL+ LQ ++ L+ + + +
Sbjct: 108 SHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDI 167
Query: 661 --LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKC-AS 717
+QE + L E +L+ + ++++ ++ +NS E +L+ ++ LK S
Sbjct: 168 ISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSD-QSEICKLQNIIKELKQNRS 226
Query: 718 MKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQK----TLE 773
++ Q E L++ +Q +L + S + E L + ++ LQ+ +E
Sbjct: 227 QEIDDHQHEMSVLQNAHQQ-----KLTEISRRHREELSDYEERIEELENLLQQGGSGVIE 281
Query: 774 NSNKKIQQLESELQDLEMENQTLQKNLEEL----KISSKRLEQLEKENKSLEQETSQLEK 829
KI +++ +Q L++E K +E+L K +K+L E + L +E QL
Sbjct: 282 TDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNV 341
Query: 830 DKKQLEKENKRLR------QQAEIK--DTTLEENNVKIGNLEKENK-TLSKEIGIYKESC 880
+K+Q+ +E + L+ Q + +K DT E+ + + E L + + +
Sbjct: 342 EKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEI 401
Query: 881 VRLKELEKENKELVKRATIDIKTLVTLRE-DLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
+RL L ++N + ++ V +E L+S++ + QM+ L KL +E E I
Sbjct: 402 MRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMS--LLKLNNEYEVIKSTA 459
Query: 940 ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
R + + D R L E+K E L +S+ KE IA +EE NQ+ + +
Sbjct: 460 TRDISLDSELHDLRLNL-EAK-EQELNQSISEKETLIA----EIEELDRQNQEATKHMIL 513
Query: 1000 VKKNYEALKQRQDEERMVQSSPPISGEDNK-----WERESQETTRELLKVKDRLIEVERN 1054
+K + L ++Q+E + S D K E + + T+EL K++LI+ E
Sbjct: 514 IK---DQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVA 570
Query: 1055 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVE---- 1110
L KQ L+ +++ L Q N Q +++Q++ + L+E + + ++++ E
Sbjct: 571 LNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQS 630
Query: 1111 ---NSTLNSQSTSLMNQNAQ---LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE 1164
+S N + T L + A+ L S LE NE++ K D+K ++EKL
Sbjct: 631 LNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKM-------ENEKLV 683
Query: 1165 LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED---RYNQLLKQKGQLEDLEKMLKV 1221
L E + E ++ + L S KN VE +E +K LE+ K K
Sbjct: 684 LACEDVRHQLEECLAGNNQL-SLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKT 742
Query: 1222 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1281
+E N N + E++ L N + + ++L K E + TDHK K +L++S E
Sbjct: 743 IEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEE 802
Query: 1282 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL-----------------KGNLEEEN 1324
Q +L +K + ++L S+KL + + SQ G+++EEN
Sbjct: 803 QKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEEN 862
Query: 1325 RHLLDQIQTLM-LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKF 1383
HL ++++ L Q+RT + ++ D + ++++L KE LEE+I K
Sbjct: 863 NHLQEELERLREEQSRTAPVADPKTLD----SVTELASEVSQLNTIKEHLEEEIKHHQKI 918
Query: 1384 YDPSPPRRRGNWITLKMRKLIKSKKDINRER----QKSLTLTPTRSDSSEGFLQLP---- 1435
+ + ++ L + KK+++ R Q + T T + E L
Sbjct: 919 IEDQNQSK-----MQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIE 973
Query: 1436 ------HQDSQDSSSVGSNSLEDG--QTLGTKKSSTMNDL 1467
H++ QD + S+ ++ Q+L + S +DL
Sbjct: 974 QIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDL 1013
Score = 129 bits (324), Expect = 3e-29
Identities = 250/1255 (19%), Positives = 509/1255 (40%), Gaps = 195/1255 (15%)
Query: 66 KKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEV---- 121
KKV D + L + ++ +E L +SL I+ + E+G E
Sbjct: 669 KKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIV-ETLKMEKGEIEAELCW 727
Query: 122 -KKLLLLLLGCAVQCQKKEEFIERIQGL-DFDTKAAVAAHIQEVTHNQENVFDLQWMEVT 179
KK LL + K E+ IE + + +T A H + NQ+ ME+
Sbjct: 728 AKKRLL------EEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKD-----MEIA 776
Query: 180 DMSQEDIEPLLKNMALHLKRLIDERD-EHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
+ LK+ I++ D +H ET LS + L + +
Sbjct: 777 E----------------LKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKL 820
Query: 239 GMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298
+ ++ ++ L + + A K LRQ +EEK L K+E ++ EL+RL++E
Sbjct: 821 KERSSKLQEELD-KYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRT 879
Query: 299 --LSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVL 356
++D ++ LD++ E A V S+++ KE L EE+K +++
Sbjct: 880 APVADPKT-------LDSVTELASEV----SQLNTIKEHLE---------EEIKHHQKII 919
Query: 357 LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE--------EL 408
+ L+ + + ++ E ++ Q+ A + +E+D + K ++ +L
Sbjct: 920 EDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL 979
Query: 409 MEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
EE ++ E+ +E S +LS+A + L + E + L +
Sbjct: 980 HEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKE-RELEIKLLNEK 1038
Query: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS 528
N SLTK +++L + ++ K+ + Q+ +++ L I + Q+ L
Sbjct: 1039 NISLTKQIDQL---------SKDEVGKLTQIIQQKDLEIQALHARISSTSHT-QDVVYLQ 1088
Query: 529 KDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKE 588
+ L + EK L E + +EN HL + A +K ++ E
Sbjct: 1089 QQLQAYAMEREKVFAVLNEKT--------RENSHLKTEYHKMMDIVAAKEAALIK-LQDE 1139
Query: 589 NKIL--------HESIKETSSKLSKIEFEK-----------RQIKKELEHYKEKGERAEE 629
NK L + +ET LS+I EK + + L+ E
Sbjct: 1140 NKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGV 1199
Query: 630 LENELHHLEKENELLQKKITNLKITCEKI----EALEQENSELERENRKLKKTL--DSFK 683
N+ L +E + L++++ ++ +++ + ++ E+++L+ E +L+ + DS
Sbjct: 1200 NSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDN 1259
Query: 684 NLTFQ------LESLEKENSQLDEENLELRRNVESL----KCASMKMAQLQLENKELESE 733
N Q ++S E+ ++L EL + S+ + + +L + + +L S
Sbjct: 1260 NSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSA 1319
Query: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
+ E L+AS K+E L S ++ LQ+ LE K +Q+ ++ ++
Sbjct: 1320 SLLTPQSAECLRAS--KSEVLSES-------SELLQQELEELRKSLQEKDATIR------ 1364
Query: 794 QTLQKNLEELKISSKRLEQLE-KENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852
TLQ+N L S +LE KE++ + E QL++ + L+K K + K L
Sbjct: 1365 -TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL 1423
Query: 853 EENNVKIGNLEKENKTLSKEIGIYKESCVRLK----ELEKENKELVKRATIDIKTLVTLR 908
+N N EN+ L + + KE + L+ +L+ EN+++V+ + T
Sbjct: 1424 LSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVET----YRGKETEY 1479
Query: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKS 968
+ L +K M + E H +++ L E+LL +++ L + ++S +K+
Sbjct: 1480 QALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKT 1539
Query: 969 LEIKEEK----IAALEARLEESTNYNQQLRQELKTVKKNYEALKQR-------------- 1010
+ ++E+ +A + ++E + N+ R K + N E + R
Sbjct: 1540 VVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREA 1599
Query: 1011 ---QDEERMVQSSPPISGE-----DNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1062
+D E ++ + E N E S + + ++ ++++L V + +
Sbjct: 1600 LAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQL 1659
Query: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1122
+ Q+KQ NLQ + Q++ ++ +A+L+ + + +
Sbjct: 1660 SVSQEQVKQYALSLANLQMVLEHFQQEEKAM---------YSAELEKQKQLIAEWKKNAE 1710
Query: 1123 NQNAQLLIQQSSLENENESV-----IKEREDLKSLYDSLIKDHEKL--ELLHERQASEYE 1175
N +++ Q L+ N ++ + E+ D+K +K +L E+L + Q
Sbjct: 1711 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMS 1770
Query: 1176 SLISKHGTL-KSAHKNLEVEH-RDLEDRYNQLLKQKGQL-----EDLEKMLKVEQ 1223
S G + K +NL + H +++ +++L+ G + E++E++ +Q
Sbjct: 1771 LANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHDDQ 1825
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 183 bits (465), Expect = 1e-45
Identities = 283/1309 (21%), Positives = 577/1309 (44%), Gaps = 224/1309 (17%)
Query: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
DA + +R L + + + D +Q+L + + LQQ++ + ++ R +L
Sbjct: 383 DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTG 442
Query: 315 LREK-AVRVDKLESEV-SRYKERLHDIEFYKARVEELKEDNQVLLET-----KTMLEDQL 367
R+ A + L+ EV S KER E + EEL++ +VL + + +E QL
Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKER----ELLQKAREELRQQLEVLEQEAWRLRRVNVELQL 498
Query: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427
+G A+ K + E+ +L ++ + EM ++ K+ E L E +TL A ES
Sbjct: 499 QGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESL-SELITLREAL-----ESS 552
Query: 428 HLGWEL---EQISRTSELSEAPQK---------SLGHEVNELTSS--------------- 460
HL EL EQ T+ L+ A Q +L EV +L ++
Sbjct: 553 HLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDK 612
Query: 461 -----RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515
+LL+LE ENQS+ +E ++++ + + + EK + L +K LE ++
Sbjct: 613 VGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD---LAEAEKRREALWEKNTHLEAQLQ 669
Query: 516 QEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER---QIKILEQENEHLNQTVSSLRQ 572
+ +++ Q +D+ +EK +++K + R E Q++ L QE + + ++ Q
Sbjct: 670 KAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQ 729
Query: 573 ------RSQISAEARVKDIEKENKILHESIKETSSKLSKIE---FEKRQIKKELEHYKEK 623
R + + E R++ +E++ + L E ++ SS +E FE +Q +E K
Sbjct: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG- 788
Query: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELEREN----RKLKKTL 679
+LE ++ + + E++Q ++ LK+ L+ E S+ E+E R+L +
Sbjct: 789 -----QLEVQIQTVTQAKEVIQGEVRCLKLE------LDTERSQAEQERDAAARQLAQAE 837
Query: 680 DSFKN-LTFQLESLEKENSQLDEE--------NLELRRNVESLKCASMKMAQLQLENKEL 730
K L Q + EKE +QL E+ EL + +ESL+ M++ +++L+ ++
Sbjct: 838 QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMEL-EMRLKEQQT 896
Query: 731 ESEKEQLKKGLELLKASFKKTE-RLEVSYQGLDIENQRLQ--KTLENSNKKIQQLESELQ 787
E E Q ++ E +A + +LE + + + LQ K L ++++++++L +++
Sbjct: 897 EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMK 956
Query: 788 DLEMENQT----LQKNLEELKISSKRLEQLEKEN-KSLEQETSQLEKDKKQLEKENKRLR 842
+++ Q LQ L+E + K + +++ +L++E+S L +DK L+K+ + L+
Sbjct: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
Query: 843 QQAEIKDTTL----EENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRAT 898
Q +D + +E K+ ++ N+ + KE+ K S + L +EKE + LV +
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNR-IQKELEREKAS-LTLSLMEKEQRLLVLQEA 1074
Query: 899 IDIKT--LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL 956
I+ L LR+D+ + + ++++ +E L E+++ + L + Q ++
Sbjct: 1075 DSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE--KEADFLAQEAQLLEELEASH 1132
Query: 957 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT---------VKKNYEAL 1007
+ E L+ SL +E K A L+ RL + + + L E + + Y AL
Sbjct: 1133 IT---EQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSAL 1189
Query: 1008 KQRQDEERMVQSSPPISGEDNK----WERE--------------------SQETTRELLK 1043
+Q + +S P +SG + W E ++ L K
Sbjct: 1190 QQALGS--VCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHK 1247
Query: 1044 VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ 1103
+ L + ++ L+ + Q L+ +L E + + + ++ LQRQ QE+ + + +
Sbjct: 1248 LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK 1307
Query: 1104 NAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE------------------SVIKE 1145
L+ E L+ SL ++ + +Q+ + E E +V++
Sbjct: 1308 QNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEA 1367
Query: 1146 R----------EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH 1195
R EDL++ +L +E++E ER + E K K+ +NL +
Sbjct: 1368 RAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLT 1427
Query: 1196 RDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLL-------ENKNHETVAAEYKKLCGEND 1248
+ L +R ++ +GQ+++LEK ++++ + L N+ + + ++L
Sbjct: 1428 QTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRS 1487
Query: 1249 RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQ----------- 1297
L H + + + L + ++ L + + ++ LE + +L+++ Q
Sbjct: 1488 VLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQD 1547
Query: 1298 -------------QLDITSTKLNNQCELLSQLKG--------------NLEEENRHLLDQ 1330
+L+ K+ Q +L+ +L+G +LEE ++ L Q
Sbjct: 1548 LKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQ 1607
Query: 1331 IQTL--MLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
+ + + T+L + ++ +D QR+ I+ EL+RQKE L + +
Sbjct: 1608 SSQIHDLESHSTVLARELQERDQEVKSQREQIE---ELQRQKEHLTQDL 1653
Score = 154 bits (390), Expect = 6e-37
Identities = 284/1383 (20%), Positives = 569/1383 (41%), Gaps = 226/1383 (16%)
Query: 132 AVQCQKKEEFIERIQGL---DFDTKAAVAAHIQEVTHNQENVFDL--------QWMEVTD 180
A+Q Q++EE + L +T+ + ++ + Q+ + D Q M+V
Sbjct: 900 AIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQK 959
Query: 181 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM 240
+ +++ +L+ +R + E + RD L L SSS
Sbjct: 960 LKEQETTGILQTQLQEAQRELKEAAR---------QHRDDLAALQEESSSL--------- 1001
Query: 241 KRTESRQHLSVELADAKAKI-------RRLRQELEEK---TEQLLDCKQELEQMEIELK- 289
+ + L ++ D K+++ R + QE++EK T++ ++ELE+ + L
Sbjct: 1002 --LQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL 1059
Query: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
L ++ LL + + + EL ALR+ + E+S E L +E+
Sbjct: 1060 SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLR---------QEV 1110
Query: 350 KEDNQVLLETKTMLEDQLEGTRARSDKLHEL----EKENLQLKAKLHDMEMERDMDRKKI 405
KE L + L ++LE + +L E + QL+ +L E + +
Sbjct: 1111 KEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQ-------L 1163
Query: 406 EELMEENMTLEMAQKQSMDESLH------LGWELEQISRTSELSEAPQKSLGHEVNELTS 459
E L E AQ Q+ SL+ LG E S ++ G E ++ +
Sbjct: 1164 EALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGA 1223
Query: 460 SRLLK----------------LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503
L K L +Q L KT + D V+ ++ E E ++
Sbjct: 1224 RSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQV 1283
Query: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER----------QI 553
+++ L+ ++ Q ++ + L E +L +T+ +L+ R +
Sbjct: 1284 HTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGER 1343
Query: 554 KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
++L+ E+L V L Q + + A A+ IL E ++ S L
Sbjct: 1344 ELLQAAKENLTAQVEHL-QAAVVEARAQASAAG----ILEEDLRTARSAL---------- 1388
Query: 614 KKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITC----EKIEALEQENSELE 669
K + E + + ERA+ L+ + + + LQ+ + L T E++E L + ELE
Sbjct: 1389 KLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE 1448
Query: 670 RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCAS----MKMAQLQL 725
++ K L+ L+K N ++D + +++ E KC S + MA +
Sbjct: 1449 KQREMQKAALELLSL------DLKKRNQEVDLQQEQIQ---ELEKCRSVLEHLPMAVQER 1499
Query: 726 ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE 785
E K L ++EQ++ EL K ++T+R + +Q L++E + + +E+ ++Q L+ +
Sbjct: 1500 EQK-LTVQREQIR---ELEKD--RETQRNVLEHQLLELEKK--DQMIESQRGQVQDLKKQ 1551
Query: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
L LE L++N +++ K +++LE + ++ + L D LE+ ++ L+ Q+
Sbjct: 1552 LVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLD---LEERSQELQAQS 1608
Query: 846 EIKDTTLEENNVKIGNLEKENKTLSKEI----GIYKESCVRLKELEKENKELVKRATIDI 901
+I +LE + L++E+ K +++EL+++ + L +
Sbjct: 1609 S-----------QIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRD 1657
Query: 902 KTLVTLREDL-VSEKLKTQQ---MNNDLEKLTHELEKIG--LNKERLLHDEQSTDDSRYK 955
+ L+ +E + V E +T+Q + DLE++ L + G L +R L E++ +
Sbjct: 1658 QELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPS 1717
Query: 956 LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL----KTVKKNYEALKQRQ 1011
+ +K L KE+++ + + E QL Q+L + V + L QR+
Sbjct: 1718 KAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQRE 1777
Query: 1012 DEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ 1071
E ++Q + E + + +S ++ +L E +R A E +AL+ + +Q
Sbjct: 1778 QEIVVLQQQLQEAREQGELKEQS---------LQSQLDEAQRALAQRDQELEALQQEQQQ 1828
Query: 1072 LETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQ 1131
+ Q ++ + ALQ +L++ + TL+ ++ +LQ + A+ L +
Sbjct: 1829 AQGQEERVKEKADALQG---ALEQAHMTLKERHGELQDH------------KEQARRLEE 1873
Query: 1132 QSSLENENESVIKE-REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1190
+ ++E ++E DL+ + ++ EK L ++Q +E +
Sbjct: 1874 ELAVEGRRVQALEEVLGDLR----AESREQEKALLALQQQCAEQA-------------QE 1916
Query: 1191 LEVEHRDLEDRYNQ---LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN 1247
EVE R L+D + Q +LK++ Q +LE + Q E A + L +
Sbjct: 1917 HEVETRALQDSWLQAQAVLKERDQ--ELEALRAESQSSRHQEEAARARAEALQEALGKAH 1974
Query: 1248 DRLNHTYSQLLKETEV---LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1304
L LL++ E+ L+ L++ L+ + +LE + + Q D+
Sbjct: 1975 AALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL--- 2031
Query: 1305 KLNNQCELLSQLKGNLEEENRH-----------LLDQIQTLMLQNRTLLEQNMESKDLFH 1353
+ + L Q +EE RH L ++Q M+Q + L Q E +++
Sbjct: 2032 RYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRG 2091
Query: 1354 VEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRE 1413
+ Q +L ++++E LE + Q + P + + + + KL + + RE
Sbjct: 2092 LHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRE 2151
Query: 1414 RQK 1416
++
Sbjct: 2152 LER 2154
Score = 147 bits (370), Expect = 1e-34
Identities = 235/1066 (22%), Positives = 461/1066 (43%), Gaps = 149/1066 (13%)
Query: 239 GMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKR------LQ 292
G E+ L+ LA+ + ++ LR +++E +Q K LE + ++LK+ LQ
Sbjct: 1416 GKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ 1475
Query: 293 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352
QE + L RS L + V + E +++ +E++ ++E + + E
Sbjct: 1476 QEQIQELEKCRSV---------LEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEH 1526
Query: 353 NQVLLETKT-MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411
+ LE K M+E Q + +L LE L+L+ H ME ++ K I+EL +
Sbjct: 1527 QLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQ----KLIKELEGQ 1582
Query: 412 NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE---LTSSRLLKLEME 468
T +A HL +LE+ R+ EL Q S H++ + + L + + E
Sbjct: 1583 RETQRVALT-------HLTLDLEE--RSQELQA--QSSQIHDLESHSTVLARELQERDQE 1631
Query: 469 NQSLTKTVEELRT-----TVDSVEGNASKILKMEK----ENQRLSKKVEILENEIVQEKQ 519
+S + +EEL+ T D + +L+ E+ E+QR +++ +ILE ++ Q K
Sbjct: 1632 VKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQR-TRQTKILEEDLEQIKL 1690
Query: 520 SLQNCQN---LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQI 576
SL+ + LM+E+A+ K + S +K++ ++ E + Q+ I
Sbjct: 1691 SLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVEC-----QQEHI 1745
Query: 577 SAEARVKD-IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE-LENEL 634
+KD +E++ + LH + ETS LS+ E E ++++L+ +E+GE E+ L+++L
Sbjct: 1746 HELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL 1805
Query: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE-SLE 693
E + L Q+ +++EAL+QE + + + ++K+ D+ + Q +L+
Sbjct: 1806 D--EAQRALAQRD--------QELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK 1855
Query: 694 KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE-KEQLKKGLELLKASFKKTE 752
+ + +L + + RR E L ++ L+ +L +E +EQ K L L + ++ +
Sbjct: 1856 ERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ 1915
Query: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK-------- 804
EV + L + Q L+ +++++ L +E Q + + + E L+
Sbjct: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHA 1975
Query: 805 -ISSKRLEQLEKE--NKSLEQETSQLEKDKKQLEKENKRLR-----QQAEIKDTTLE--- 853
+ K LE+ ++SLE T+ L+ + +++L Q+ EI+D L
Sbjct: 1976 ALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQE 2035
Query: 854 ----------ENNVKIGNLEKENKTLSKEIGI-YKESCVRLKE---LEKENKEL--VKRA 897
+ + ++ + ++ + L K + +E+ ++ K+ E+E +E+ + ++
Sbjct: 2036 DVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQS 2095
Query: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLL 957
+++ + +E + E +TQQ NN LE L H H ++ KL
Sbjct: 2096 VRELQLTLAQKEQEILELRETQQRNN-LEALPHS------------HKTSPMEEQSLKL- 2141
Query: 958 ESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ-------- 1009
LE L++ LE + + EAR E Q L L K + +L++
Sbjct: 2142 -DSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQAS 2200
Query: 1010 ---RQDEERMVQSSPPISGEDNKWER---ESQETTRELLKVKDRLIE------VERNNAT 1057
R E++ +Q ++ + ER +T EL ++ ++ VE +
Sbjct: 2201 VLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSP 2260
Query: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVE-NSTLNS 1116
EKQ+ + +L+ L+ L+ LQR V L+ ++ + KL+ E +
Sbjct: 2261 DGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQA 2320
Query: 1117 QSTSLMNQNAQLLIQQSSLENEN---ESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1173
S + A QQ +N + V + ++++ L L + ++ + R A
Sbjct: 2321 GSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQT 2380
Query: 1174 YESLISKHGTLKSA---------HKNLEVEHRDLEDRYNQLLKQKG 1210
L H +L + LE E R L++ Q L G
Sbjct: 2381 SRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPG 2426
Score = 143 bits (360), Expect = 2e-33
Identities = 232/1219 (19%), Positives = 516/1219 (42%), Gaps = 133/1219 (10%)
Query: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
+ + ++ L E A + +++ + ++ ++ EQL E +E L QQ+N +
Sbjct: 726 RAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEV 785
Query: 301 DARSARMYRDELDALRE---KAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
+ + +E VR KLE + R + + + +E L
Sbjct: 786 TKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE 845
Query: 358 ETKTMLEDQLEGTRARSDK------------LHELEKENLQLKAKLHDMEMERDMDRKKI 405
+ K E ++ R + +K L LE+E ++L+ +L + + E + + +
Sbjct: 846 QQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQR 905
Query: 406 EE--------LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457
EE L + + E + ++ L EL S+ E K + E
Sbjct: 906 EEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQET 965
Query: 458 TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK----MEKENQRLSKKV------ 507
T +L+ + L + + R + +++ +S +L+ ++K+ + L ++
Sbjct: 966 TGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDS 1025
Query: 508 -EILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
++E E+ ++ + Q + K+L +EKA L ++ E+++ +L++ + Q
Sbjct: 1026 QRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSL----MEKEQRLLVLQEADSIRQQE 1081
Query: 567 VSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE--HYKEKG 624
+S+LRQ Q A+ K++ + ++L + +KE K + ++ Q+ +ELE H E
Sbjct: 1082 LSALRQDMQ-EAQGEQKELSAQMELLRQEVKE---KEADFLAQEAQLLEELEASHITE-- 1135
Query: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN 684
++L L E + LQ ++ + + E + A +Q ++ + +
Sbjct: 1136 ---QQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ-----------AQ 1181
Query: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCA-----SMKMAQLQLENKELES--EKEQL 737
L +L++ + E EL +S A+ + L + E +
Sbjct: 1182 LASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAV 1241
Query: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQ 797
L L KT++ + L + Q+L++ L ++ + Q+ +ELQDL+ + L
Sbjct: 1242 ASALHKLHQDLWKTQQ---TRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQ---LS 1295
Query: 798 KNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV 857
+N EE + LE E L + + L+ ++ E + + + E+ E
Sbjct: 1296 QNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTA 1355
Query: 858 KIGNLEK---ENKTLSKEIGIYKE------SCVRLKELEKENKE-----LVKRATIDIKT 903
++ +L+ E + + GI +E S ++LK E E++ L ++ + +
Sbjct: 1356 QVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQ 1415
Query: 904 LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLES 963
L+E+L + ++E L ++++ L ++ + +LL L+
Sbjct: 1416 GKALQENLALLTQTLAEREEEVETLRGQIQE--------LEKQREMQKAALELLSLDLKK 1467
Query: 964 TLKKSLEIKEEKIAALE---ARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS 1020
+ +++++E+I LE + LE Q+ Q+L ++ L++ ++ +R V
Sbjct: 1468 R-NQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEH 1526
Query: 1021 PPISGEDNKWERES-----QETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ 1075
+ E ES Q+ ++L+ ++ +E+E N+ ++ +++ +K Q ETQ
Sbjct: 1527 QLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQ 1586
Query: 1076 NNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSL 1135
+AL T+ L+E++ LQ Q++++ S + L ++ ++ Q+ +
Sbjct: 1587 R-------VALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQI 1639
Query: 1136 ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE----YESLISKHGTLKSAHKNL 1191
E +DL+ L+ E++++L +++ + E L +L+ + L
Sbjct: 1640 EELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGREL 1699
Query: 1192 EVEHRDLEDRYNQ----LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYK-----K 1242
+ + +++R + Q+G LE ++ +L+ ++EK + + H E K +
Sbjct: 1700 TTQRQLMQERAEEGKGPSKAQRGSLEHMKLILR-DKEKEVECQQEHIHELQELKDQLEQQ 1758
Query: 1243 LCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDIT 1302
L G + ++ T L + + + + L+ +L++ L+++ + + Q D
Sbjct: 1759 LQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQE 1818
Query: 1303 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQ-NRTLLEQNMESKDLFHVEQ-RQYI 1360
L + + Q +G EE + D +Q + Q + TL E++ E +D H EQ R+
Sbjct: 1819 LEALQQEQQ---QAQGQ-EERVKEKADALQGALEQAHMTLKERHGELQD--HKEQARRLE 1872
Query: 1361 DKLNELRRQKEKLEEKIMD 1379
++L R+ + LEE + D
Sbjct: 1873 EELAVEGRRVQALEEVLGD 1891
Score = 108 bits (269), Expect = 6e-23
Identities = 222/1055 (21%), Positives = 432/1055 (40%), Gaps = 116/1055 (10%)
Query: 467 MENQSLTKTVEE--LRTTVDSVEGNAS---KILKMEKENQRLSKKVEILENEIVQEKQSL 521
M+ QSL +EE L E A+ K+ ++ QR + V L+ +++Q +
Sbjct: 11 MKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSW- 69
Query: 522 QNCQNLSKDLMKEKAQLEKTIETLRE-NSERQIKILEQEN---EHLNQTVSSLR---QRS 574
CQ L K L + + E + E N + + LE+E E L + + LR +++
Sbjct: 70 --CQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKA 127
Query: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL--EHYKEKGERAEELEN 632
+ +A +D+EK + E K S+ + E+ K L EH + E +
Sbjct: 128 DVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTF 187
Query: 633 ELHHLEKEN----ELLQKKITNLKIT------CEKIEALEQE---NSELERENRK----- 674
H LE ++ +L++ K +++++ C ++ Q N + R+
Sbjct: 188 RRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL 247
Query: 675 --LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELES 732
L KT + K + + L + SQ D E EL+ V L S + Q Q +N++ E
Sbjct: 248 LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTEL---SALLTQSQKQNEDYEK 304
Query: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792
+ L++ +E+L+ + + E S L Q + +L+ K I Q+ E D +
Sbjct: 305 MIKALRETVEILETNHTELMEHEAS---LSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361
Query: 793 NQTLQKNLEELKISSKRLEQLEKEN--KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850
+ +LE + S Q + ++ K+L S L + ++ ++ ++L E +
Sbjct: 362 GSGHENSLE---LDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNL 418
Query: 851 TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED 910
++++ E+E K L + RL++L E L + T+D++ V +
Sbjct: 419 LQQQHD----QWEEEGKALRQ----------RLQKLTGERDTLAGQ-TVDLQGEV---DS 460
Query: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST--LKKS 968
L E+ Q+ +L + LE+ R+ + Q DS E + E +
Sbjct: 461 LSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE 520
Query: 969 LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-----ERMVQSSPPI 1023
E +E + LEA+ ES + LR+ L++ E L+Q Q E R QS +
Sbjct: 521 RERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAEL 580
Query: 1024 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1083
S +N + E + ++ +++ N L +K L QL QLE +N ++ +++
Sbjct: 581 SSSENTLKTEVAD-------LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRM 633
Query: 1084 LALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1143
A ++ +LQ + + L +N+ L +Q A+L ++ E E +
Sbjct: 634 EAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQ 693
Query: 1144 K-------EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1196
K ++E + + L ++ ++ E + R E E+L+ + L+ + +E + +
Sbjct: 694 KKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQ 753
Query: 1197 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1256
DL ++ L K LE + + +Q+ ++E +L
Sbjct: 754 DLAEQLQGLSSAKELLE--SSLFEAQQQNSVIE---------------VTKGQLEVQIQT 796
Query: 1257 LLKETEVLQTDHKNLKSLLN--NSKLEQTR-LEAEFSKLKEQYQQLDITSTKLNNQCELL 1313
+ + EV+Q + + LK L+ S+ EQ R A EQ + + K ++ E +
Sbjct: 797 VTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKE-V 855
Query: 1314 SQLKGNLEEENR-HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEK 1372
+QL+ E+E H + + L R +E M K EQ+ ++ + R ++
Sbjct: 856 NQLREKWEKERSWHQQELAKALESLEREKMELEMRLK-----EQQTEMEAIQAQREEERT 910
Query: 1373 LEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFL 1432
E + Q + + ++L + + + R RQ + + + + G L
Sbjct: 911 QAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQ-DMKVQKLKEQETTGIL 969
Query: 1433 QLPHQDSQ-DSSSVGSNSLEDGQTLGTKKSSTMND 1466
Q Q++Q + +D L + SS + D
Sbjct: 970 QTQLQEAQRELKEAARQHRDDLAALQEESSSLLQD 1004
Score = 84.3 bits (207), Expect = 1e-15
Identities = 158/702 (22%), Positives = 305/702 (43%), Gaps = 102/702 (14%)
Query: 190 LKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHL 249
L++M L L+ E + E I EL E +D L G + ++ Q +
Sbjct: 1724 LEHMKLILRDKEKEVECQQEHIHELQELKDQLE---QQLQGLHRKVGETSLLLSQREQEI 1780
Query: 250 SV---ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
V +L +A+ + Q L+ QL + ++ L Q + EL+ LQQE + + R
Sbjct: 1781 VVLQQQLQEAREQGELKEQSLQS---QLDEAQRALAQRDQELEALQQEQQQ--AQGQEER 1835
Query: 307 MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366
+ +++ DAL+ LE KER +++ +K + L+E+ V LE+
Sbjct: 1836 V-KEKADALQ------GALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEV 1888
Query: 367 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE--------LMEENMTLEMA 418
L RA S E EK L L+ + + E +++ + +++ L E + LE
Sbjct: 1889 LGDLRAES---REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEAL 1945
Query: 419 QKQSMDESLHLGWELEQISRTSELSEAPQKSLG--HEVNELTSSRLLKLEMENQSLTKTV 476
+ +S E+ +R +EA Q++LG H + LL+ ++SL +
Sbjct: 1946 RAESQSSR-----HQEEAARAR--AEALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998
Query: 477 EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
L+ ++D+ + ++ ++L + + I E EI + Q +D+ + +
Sbjct: 1999 ATLQASLDACQAHS----------RQLEEALRIQEGEIQDQDLRYQ------EDVQQLQQ 2042
Query: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596
L + E LR ER+ ++LE+ Q + ++++ + E E+E + LH+S+
Sbjct: 2043 ALAQRDEELRHQQERE-QLLEKSLAQRVQE-NMIQEKQNLGQERE----EEEIRGLHQSV 2096
Query: 597 KETSSKLSK-----IEFEKRQIKKELEH--YKEKGERAEELENELHHLEKENELLQKKIT 649
+E L++ +E + Q + LE + K EE +L LE LQ+++
Sbjct: 2097 RELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPR---LQRELE 2153
Query: 650 NLKITCEKIEALE----QENSELERENRKLKKTLDSFKNLTFQLES--LEKENSQLD-EE 702
L+ + EA E ++ +L + K ++ S + + L++ LE+++ Q ++
Sbjct: 2154 RLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQD 2213
Query: 703 NLEL-RRNVESLKCAS---MKMAQLQLENKELES-------EKEQLKKGLELLKASFK-K 750
LEL RR +E + S A+L ++ E E G+E K S++ +
Sbjct: 2214 ELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGME--KQSWRQR 2271
Query: 751 TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKR 809
E L+ + L+I+ RLQ + QL S L+ +E E + L++ + + S
Sbjct: 2272 LEHLQQAVARLEIDRSRLQ-------RHNVQLRSTLEQVERERRKLKREAMRAAQAGSLE 2324
Query: 810 LEQLEKENKSLEQETSQLEKDKK---QLEKENKRLRQQAEIK 848
+ + + + + Q D K +L+KE L+ Q ++
Sbjct: 2325 ISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLE 2366
Score = 58.9 bits (141), Expect = 4e-08
Identities = 108/543 (19%), Positives = 226/543 (41%), Gaps = 60/543 (11%)
Query: 116 QGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQW 175
+ E+ K LL L CA Q Q+ E +T+A + +Q +E +L+
Sbjct: 1895 ESREQEKALLALQQQCAEQAQEHE----------VETRALQDSWLQAQAVLKERDQELEA 1944
Query: 176 MEVTDMSQEDIEPLLKNMALHLKRLIDE-------RDEHSETIIELSEERDGLHFLPHAS 228
+ S E + A L+ + + +++H ELS + AS
Sbjct: 1945 LRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQAS 2004
Query: 229 SSAQSPCGSPGMKRTESRQHLSVELADAKAK----IRRLRQELEEKTEQLLDCKQELEQM 284
A C + + E+ + E+ D + +++L+Q L ++ E+L ++ + +
Sbjct: 2005 LDA---CQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
Query: 285 EIELKRLQQENM----NLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKE--RLHD 338
E L + QENM L R R ++RE + + + E E+ +E + ++
Sbjct: 2062 EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNN 2121
Query: 339 IEF--YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEM 396
+E + + ++E + L + L+ +LE +A L + E ++ + K D+ +
Sbjct: 2122 LEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQA---ALRQTEAREIEWREKAQDLAL 2178
Query: 397 ERDMDRKKIEELMEENMTLEM------AQKQSMDESLHL---GWELEQISRTSELSEAPQ 447
+ + L E M L+ +++Q + + L L E E++ S A
Sbjct: 2179 SLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAEL 2238
Query: 448 KSLGHEVNELTSSRLLKLE-----MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQR 502
S G + +L ++ E ME QS + +E L+ V +E + S ++++ N +
Sbjct: 2239 GSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRS---RLQRHNVQ 2295
Query: 503 LSKKVEILENEIVQ-EKQSLQNCQNLSKDLMKEKAQLEKTIETL-RENSERQIKILEQEN 560
L +E +E E + ++++++ Q S ++ K A + ++NS+ + Q+
Sbjct: 2296 LRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKE 2355
Query: 561 EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKET------SSKLSKIEFEKRQIK 614
L Q +L ++ + R +E LH S+ + + + + +E E R++
Sbjct: 2356 VVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLD 2415
Query: 615 KEL 617
+ L
Sbjct: 2416 ESL 2418
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 181 bits (459), Expect = 6e-45
Identities = 258/1122 (22%), Positives = 486/1122 (43%), Gaps = 115/1122 (10%)
Query: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE-----------QMEIELKRLQ 292
E Q ELA ++AK R+ELEEK LL K +L+ E ++L
Sbjct: 857 EEFQKTKDELAKSEAK----RKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLI 912
Query: 293 QENMNLLSDARSARMYRDELDALR-EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE 351
+ + L + + +E + + E + KLE E S K+ + D+E A+VE+ K
Sbjct: 913 KNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 972
Query: 352 DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ--LKAKLHDMEMERDMDRKKIEELM 409
+ ++ T L+ T A+ K EK+ LQ + L D++ E D K+ L
Sbjct: 973 ATENKVKNLTEEMAGLDETIAKLSK----EKKALQETHQQTLDDLQAEED----KVNILT 1024
Query: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
+ LE Q +D+ L LEQ + E ++ L ++ +L + +E +
Sbjct: 1025 KAKTKLE----QQVDD---LEGSLEQEKKLRMDLERAKRKLEGDL-KLAQESTMDMENDK 1076
Query: 470 QSLTKTVE----ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ 525
Q L + +E E+ + +E + ++++K+ + L ++E L EI E+ S +
Sbjct: 1077 QQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE 1136
Query: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585
DL +E ++ + +E + Q++ L ++ E Q + + + + EA V +
Sbjct: 1137 KQRSDLSRELEEISERLEEAGGATSAQVE-LNKKREAEFQKLRRDLEEATLQHEAMVAAL 1195
Query: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQ 645
K++ +S+ E ++ ++ K++++KE EL+ E L E +
Sbjct: 1196 RKKHA---DSMAELGEQIDNLQRVKQKLEKE----------KSELKMETDDLSSNAEAIS 1242
Query: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKE----NSQLDE 701
K NL+ C +E E E E ++L +LT Q L+ E + QLDE
Sbjct: 1243 KAKGNLEKMCRSLEDQVSELKTKEEEQQRL------INDLTAQRARLQTEAGEYSRQLDE 1296
Query: 702 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761
++ + + S + ++ ++ +L+ +LE E + L++S + L Y+
Sbjct: 1297 KDALVSQLSRSKQASTQQIEELK---HQLEEETKAKNALAHALQSSRHDCDLLREQYEEE 1353
Query: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821
LQ+ L +N ++ Q + + E +Q+ EEL+ + K+L Q +E E
Sbjct: 1354 QEGKAELQRALSKANSEVAQWRT-----KYETDAIQRT-EELEEAKKKLAQRLQE---AE 1404
Query: 822 QETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE----NKTLSKEIGIYK 877
+ + LEK +RL+ + E +E +N L+K+ +K LS+ Y+
Sbjct: 1405 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE 1464
Query: 878 ESCVRLKELEKENK----ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE------- 926
E+ L+ +KE++ EL K + ++L L E L E QQ +DL
Sbjct: 1465 ETQAELEASQKESRSLSTELFKVKNVYEESLDQL-ETLRRENKNLQQEISDLTEQIAEGG 1523
Query: 927 KLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 986
K HELEKI E+ + Q+ + LE + L+ LE+ + K + ++ ++ E
Sbjct: 1524 KQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVK-SEVDRKIAEK 1582
Query: 987 TNYNQQLRQE----LKTVKKNYEA-LKQRQDEERMVQSSPPISGEDNKWE-------RES 1034
QL++ ++T++ +A ++ R D R+ + + G+ N+ E R +
Sbjct: 1583 DEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKK---MEGDLNEMEIQLNHANRLA 1639
Query: 1035 QETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQ 1094
E+ R + L E + + ++ LK QL +E + N LQA+I L +
Sbjct: 1640 AESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTE 1699
Query: 1095 EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD 1154
+ + L++Q+TSL+N +L S L++E E VI+E + +
Sbjct: 1700 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAK 1759
Query: 1155 SLIKDHEKL--ELLHERQASEYESLISKH--GTLKS-AHKNLEVEHRDLEDRYNQLLKQK 1209
I D + EL E+ S + + K+ T+K H+ E E L+ Q+ K +
Sbjct: 1760 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1819
Query: 1210 GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHK 1269
++ +LE ++ EQ++ K K+L + + +L + LQ K
Sbjct: 1820 ARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVK 1879
Query: 1270 NLKSLLNNSKLEQTRLEAEFSK----LKEQYQQLDITSTKLN 1307
+ K ++ + ++F K L+E ++ DI +++N
Sbjct: 1880 SYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVN 1921
Score = 154 bits (390), Expect = 6e-37
Identities = 216/1047 (20%), Positives = 453/1047 (43%), Gaps = 147/1047 (14%)
Query: 149 DFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQE--DIEPLLKNMALHLKRLIDERDE 206
D D A +++ H EN +V ++++E ++ + ++ K L ++
Sbjct: 956 DIDDLELTLAKVEKEKHATEN-------KVKNLTEEMAGLDETIAKLSKEKKAL---QET 1005
Query: 207 HSETIIELSEERDGLHFLPHASSSAQSPCGS-PGMKRTESRQHLSVELADAKAKIRRLRQ 265
H +T+ +L E D ++ L A + + G E + + +E A R+L
Sbjct: 1006 HQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAK-----RKLEG 1060
Query: 266 ELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-LREKAVRVDK 324
+L+ E +D + + +Q++ +L++ + E NL+S + +L ++E R+++
Sbjct: 1061 DLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEE 1120
Query: 325 LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384
L E+ + +A+ E+ + D LE + ++LE + EL K
Sbjct: 1121 LGEEIEAERAS-------RAKAEKQRSDLSRELEE---ISERLEEAGGATSAQVELNK-- 1168
Query: 385 LQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE 444
K + ++ RD++ E ++ + +K+ D LG +++ + R + E
Sbjct: 1169 ---KREAEFQKLRRDLE----EATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLE 1221
Query: 445 APQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLS 504
+ L E ++L+S+ ++++K L S+E S++ E+E QRL
Sbjct: 1222 KEKSELKMETDDLSSNA--------EAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLI 1273
Query: 505 KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564
N++ ++ LQ + EK L + ++ S +QI+ L+ + E
Sbjct: 1274 -------NDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEET 1326
Query: 565 QTVSSLR---QRSQISAEARVKDIEKEN-------KILHESIKETSSKLSKIEFEKRQIK 614
+ ++L Q S+ + + E+E + L ++ E + +K E + Q
Sbjct: 1327 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT 1386
Query: 615 KELEHYKEK-GERAEELENELH-------HLEKENELLQKKITNLKITCEKIEALEQENS 666
+ELE K+K +R +E E + LEK + LQ ++ +L + E+ A +
Sbjct: 1387 EELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAA---CA 1443
Query: 667 ELERENRKLKKTLDSFKN----LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
L+++ R K L +K +LE+ +KE+ L E +++ E + ++
Sbjct: 1444 ALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEE---SLDQLET 1500
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
L+ ENK L+ E L E + K+ LE + ++ E +Q LE + ++
Sbjct: 1501 LRRENKNLQQEISDLT---EQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHE 1557
Query: 783 ESELQDLEMENQTLQKNLEELKISSK--RLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
E ++ +++E ++ ++ KI+ K ++QL K N + ET Q D ++ N
Sbjct: 1558 EGKILRIQLELNQVKSEVDR-KIAEKDEEIDQL-KRNHTRVVETMQSTLDA-EIRSRNDA 1614
Query: 841 LRQQAEIKDTTLEENNVKIGNLEK----------ENKTLSKEIGIYKESCVRLKELEKEN 890
LR + +++ L E +++ + + + + KE ++ + +R +E KE
Sbjct: 1615 LRVKKKMEGD-LNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQ 1673
Query: 891 KELVKRAT----IDIKTL-VTLREDLVSEKLKTQQMNNDLEK--LTHELEKIGLNKERLL 943
+V+R +I+ L TL + S K+ Q++ + E+ L H +N ++ L
Sbjct: 1674 LAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1733
Query: 944 HDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALE--ARLEESTNYNQQLRQELKTVK 1001
++ S L+S++E +++S +E+ A+ A + E Q L+ +K
Sbjct: 1734 ENDVSQ-------LQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1786
Query: 1002 KNYEA----LKQRQDE-------------ERMVQSSPPISGEDNKWERESQETTRELLKV 1044
KN E L+ R DE +++ + GE ++ + E + L K
Sbjct: 1787 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKH 1846
Query: 1045 KDRLIEV------ERNNAT--------LQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1090
+ R+ E+ +R N LQA+ ++ K Q ++ E Q+N ++ LQ +
Sbjct: 1847 ERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHEL 1906
Query: 1091 VSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
+E+ ++Q KL+V++ ++++
Sbjct: 1907 EEAEERADIAESQVNKLRVKSREVHTK 1933
Score = 120 bits (301), Expect = 1e-26
Identities = 169/783 (21%), Positives = 340/783 (43%), Gaps = 81/783 (10%)
Query: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
+++E E+E +K+ K+ +L E + +L+E+ + L + L QL
Sbjct: 844 KSAETEKEMATMKEEFQKTKD---ELAKSEAKRKELEEKMVTLLKEKNDL--------QL 892
Query: 724 QLENK-----ELESEKEQLKKGLELLKASFKK-TERLEVSYQ---GLDIENQRLQKTLEN 774
Q++++ + E EQL K L+A K+ TER E + L + ++L+
Sbjct: 893 QVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSE 952
Query: 775 SNKKIQQLESELQDLEMENQTLQ---KNL-EELKISSKRLEQLEKENKSLEQ------ET 824
K I LE L +E E + KNL EE+ + + +L KE K+L++ +
Sbjct: 953 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD 1012
Query: 825 SQLEKDKKQ-LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL 883
Q E+DK L K +L QQ + + +LE+ +LE+ + L ++ + +ES + +
Sbjct: 1013 LQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDM 1072
Query: 884 KELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLL 943
+ +++ E +++ +I L++ ED E+ Q+ +++L +E++G E
Sbjct: 1073 ENDKQQLDEKLEKKEFEISNLISKIED---EQAVEIQLQKKIKELQARIEELGEEIEAER 1129
Query: 944 HDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN---QQLRQELKTV 1000
+ R S L L++ E EE A A++E + Q+LR++L+
Sbjct: 1130 ASRAKAEKQR-----SDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEA 1184
Query: 1001 KKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQA 1060
+EA+ ++ S + + + +R Q+ +E ++K ++ N +
Sbjct: 1185 TLQHEAMVAAL-RKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISK 1243
Query: 1061 EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTS 1120
K L+ + LE Q + L+ + QR L Q LQT+ + + ++ S
Sbjct: 1244 AKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDA-LVS 1302
Query: 1121 LMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISK 1180
++++ Q QQ +E + +E + +L +L +LL E+ E E
Sbjct: 1303 QLSRSKQASTQQ--IEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAEL 1360
Query: 1181 HGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH-ETVAAE 1239
L A+ + E +++ +LE+ +K L + L E + H E V A+
Sbjct: 1361 QRALSKANSEVAQWRTKYE---TDAIQRTEELEEAKKKL----AQRLQEAEEHVEAVNAK 1413
Query: 1240 YKKLCGENDRLNHTYSQLLKETE-------VLQTDHKNLKSLLN--NSKLEQTRLEAEFS 1290
L RL + L+ + E L +N +L+ K E+T+ E E S
Sbjct: 1414 CASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEAS 1473
Query: 1291 KLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKD 1350
+ + + ++ K N+ EE+ LDQ++TL +N+ L ++ + +
Sbjct: 1474 QKESRSLSTELFKVK-------------NVYEES---LDQLETLRRENKNLQQEISDLTE 1517
Query: 1351 LFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDI 1410
E + I +L ++++Q E+ + +I + + S G + +++ +L + K ++
Sbjct: 1518 QI-AEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQL-ELNQVKSEV 1575
Query: 1411 NRE 1413
+R+
Sbjct: 1576 DRK 1578
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 181 bits (458), Expect = 8e-45
Identities = 249/1146 (21%), Positives = 496/1146 (43%), Gaps = 166/1146 (14%)
Query: 265 QELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK 324
+EL + E+ L + L +ME +L E + L +++L A E ++
Sbjct: 852 EELVKVREKQLAAENRLTEMETLQSQLMAEKLQL----------QEQLQAETELCAEAEE 901
Query: 325 LESEVSRYKERL----HDIEFYKARVEELKEDNQVL-LETKTM------LEDQLEGTRAR 373
L + ++ K+ L HD+E ARVEE +E Q L E K M LE+QLE +
Sbjct: 902 LRARLTAKKQELEEICHDLE---ARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958
Query: 374 SDKLHELEKENLQLKAK--------LHDMEMERDMDRKKIEELM---------EENMTLE 416
KL +LEK + K K L D + ++K +E+ + EE +
Sbjct: 959 RQKL-QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKS 1017
Query: 417 MAQKQSMDESLHLGWE---------LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
+A+ ++ E++ E +++ +T E L ++ EL +++ +L+M
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL-QAQIAELKM 1076
Query: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
+ L K EEL+ + VE A++ K+ + L ++ L+ ++ E+ S +
Sbjct: 1077 Q---LAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133
Query: 528 SKDLMKE----KAQLEKTIET------LRENSERQI----KILEQENEHLNQTVSSLRQR 573
+DL +E K +LE T+++ LR E+++ K LE+E + + +RQ+
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQK 1193
Query: 574 SQISAEARVKDIEKENKI---LHESIKETSSKLSKIEFEKR---QIKKELEHYKEKGE-R 626
+ E + +E+ ++ L ++ + ++ ++ E + Q K + EH ++K E +
Sbjct: 1194 HSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ 1253
Query: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT 686
+EL+ + + E+ L K+T L++ + + L L + + K K F L
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELDNVTGL------LSQSDSKSSKLTKDFSALE 1307
Query: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
QL+ ++ L EEN + LK + + + +E E K L+K + L A
Sbjct: 1308 SQLQDTQE---LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 747 SF----KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE 802
KK E + + ++LQK LE +++ ++ + LE LQ+ L++
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424
Query: 803 LKISSKRLEQ----LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
L + Q LEK+ K +Q ++ + + +E R +A
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR------------ 1472
Query: 859 IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKT 918
EKE K LS + +E+ + ELE+ NK+ T EDL+S K
Sbjct: 1473 ----EKETKALSLARAL-EEAMEQKAELERLNKQ-----------FRTEMEDLMSSK--- 1513
Query: 919 QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST--LKKSLEIKEEKI 976
+D+ K HELEK +R L + ++ + LE +L++T K LE+ + +
Sbjct: 1514 ----DDVGKSVHELEK----SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 977 AA-----LEARLEESTNYNQQLRQELKTVKKNYEALKQRQD-----EERMVQSSPPISGE 1026
A L+ R E+S +QL ++++ ++ E ++++ +++ +
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625
Query: 1027 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1086
+ + E ++L K++ ++ + R +A ++ + Q K+ E + +++A+++ L
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQL 1685
Query: 1087 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKER 1146
Q + + + Q + +L E + + + + + +L + + LE E E +E+
Sbjct: 1686 QEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELE---EEQ 1742
Query: 1147 EDLKSLYDSLIKDHEKLELLH---ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1203
+ + + D L K + +++ ++ + S + + L+ +K L+V+ +++E
Sbjct: 1743 GNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVK 1802
Query: 1204 QLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA---------EYKKLCGENDRLNHTY 1254
K K + LE K+ Q + L+N+ E AA + K + + D
Sbjct: 1803 S--KYKASITALE--AKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNA 1858
Query: 1255 SQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLS 1314
Q + + T K LK L ++ E R A KL+ + + T+ +N + +S
Sbjct: 1859 EQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNRE---VS 1915
Query: 1315 QLKGNL 1320
LK L
Sbjct: 1916 SLKNKL 1921
Score = 164 bits (416), Expect = 6e-40
Identities = 222/1059 (20%), Positives = 465/1059 (43%), Gaps = 153/1059 (14%)
Query: 137 KKEEFIERIQGLD--FDTKAAVAAHIQ-EVTHNQENVFDLQ-WMEVTDMSQEDIEPLLKN 192
KK+E E L+ + + H+Q E Q+N+ +L+ +E + +++ ++
Sbjct: 909 KKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVT 968
Query: 193 MALHLKRLIDERDEHSETIIELSEERDGLH--FLPHASSSAQSPCGSPGMKRTESRQHLS 250
LK+L +E+ + +L++E+ L ++ + S + + +++
Sbjct: 969 TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM 1028
Query: 251 VELADAKAKIRR---LRQELEEKTEQL----LDCKQELEQMEIELKRLQQENMNLLSDAR 303
+ D + ++RR RQELE+ +L D ++ +++ ++ L+ + + +
Sbjct: 1029 I--TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ 1086
Query: 304 SARMYRDELDALREKAVR-VDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET-KT 361
+A +E A + A++ + +LES++S +E L + + E+ K D LE KT
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146
Query: 362 MLEDQLEGTRARSDKLHELEKE------NLQLKAKLHDMEME--RDMDRKKIEELMEE-- 411
LED L+ T A+ + + E+E L+ +AK H+ +++ R + +EEL E+
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 412 -----NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466
LE A++ +E L E++ + + SE +K + ++ EL + + E
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL-QVKFNEGE 1265
Query: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526
L V +L+ +D+V G S+ + ++ +L+K LE+++ ++ LQ
Sbjct: 1266 RVRTELADKVTKLQVELDNVTGLLSQ---SDSKSSKLTKDFSALESQLQDTQELLQEENR 1322
Query: 527 LSKDLMKEKAQLEKTIETLRENSERQIKI---LEQENEHLNQTVSSLRQRSQIS------ 577
L + Q+E + RE E + + LE++ L+ V+ ++++ + S
Sbjct: 1323 QKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLET 1382
Query: 578 AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE-------HYKEKGERAEEL 630
AE + ++K+ + L + +E + K+E K ++++EL+ H ++ E+
Sbjct: 1383 AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442
Query: 631 ENELHHL----------------EKENELLQKKITNLKITCEKIEALEQENSELERENRK 674
+ + L E E +K+ L + EA+EQ+ +ELER N++
Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK-AELERLNKQ 1501
Query: 675 LKKTLDSF-------------------------KNLTFQLESLEKENSQLDEENLELRRN 709
+ ++ + + QLE LE E ++ L L N
Sbjct: 1502 FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVN 1561
Query: 710 VESLKC------------ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757
++++K + K QL + +E+E+E E +K + A+ KK LE+
Sbjct: 1562 LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKK---LEMD 1618
Query: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL----KISSKRLEQL 813
+ L+ K + + K++++L+++++D E + + EE+ K + K+L+ +
Sbjct: 1619 LKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSM 1678
Query: 814 EKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI 873
E E L++E + E+ K+Q ++E L + + ++ K +E + L I
Sbjct: 1679 EAEMIQLQEELAAAERAKRQAQQERDELADE-------IANSSGKGALALEEKRRLEARI 1731
Query: 874 GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELE 933
+E E E+ N EL+ + L L+ Q+N DL +
Sbjct: 1732 AQLEEEL----EEEQGNTELI-------------NDRLKKANLQIDQINTDLNLERSHAQ 1774
Query: 934 KIGLNKERLLHDEQSTDDSRYKL--LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ 991
K +++L E+ + + KL +E ++S K S+ E KIA LE +L+ T Q
Sbjct: 1775 KNENARQQL---ERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQ 1831
Query: 992 -QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1050
+Q +T KK + L Q DE R + +++ ++ + + L ++K +L E
Sbjct: 1832 AACKQVRRTEKKLKDVLLQVDDERRNAE----------QYKDQADKASTRLKQLKRQLEE 1881
Query: 1051 VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1089
E A ++ L+ +L+ + + ++ +L+ +
Sbjct: 1882 AEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
Score = 163 bits (413), Expect = 1e-39
Identities = 213/1014 (21%), Positives = 457/1014 (45%), Gaps = 137/1014 (13%)
Query: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK-ENQRLSKKVEILENEIVQEKQS 520
LL++ + + + EEL + +++ +ME ++Q +++K++ L+ ++ E +
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQ-LQEQLQAETEL 895
Query: 521 LQNCQNLSKDLMKEKAQLEK---TIETLRENSERQIKILEQENEHLNQTVSSLR------ 571
+ L L +K +LE+ +E E E + + L+ E + + Q + L
Sbjct: 896 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955
Query: 572 -------QRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG 624
Q +++ EA++K +E+E IL ++ + KL+K EK+ ++ + +
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIIL----EDQNCKLAK---EKKLLEDRIAEFTTNL 1008
Query: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK----KTLD 680
EE L L+ ++E + IT+L+ E++ E++ ELE+ RKL+ D
Sbjct: 1009 TEEEEKSKSLAKLKNKHEAM---ITDLE---ERLRREEKQRQELEKTRRKLEGDSTDLSD 1062
Query: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740
L Q+ L+ + ++ +EE VE + A MA ++ +ELES+ +L++
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEE-EAAQKNMALKKI--RELESQISELQED 1119
Query: 741 LELLKASFKKTERLEVSY-QGLDIENQRLQKTLENS-------NKKIQQLESELQDLEME 792
LE +AS K E+ + + L+ L+ TL+++ +K+ Q++ + LE E
Sbjct: 1120 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
Query: 793 NQTLQKNLEELKIS--------SKRLEQ-------LEKENKSLEQETSQLEKDKKQL--- 834
+T + ++E++ +++LEQ LEK ++LE E +L + K L
Sbjct: 1180 AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQG 1239
Query: 835 --EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI------GIYKESCVRLKEL 886
+ E+KR + +A++++ ++ N + E +K ++ G+ +S + +L
Sbjct: 1240 KGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKL 1299
Query: 887 EK----------ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936
K + +EL++ +L T + + EK ++ + E+ H LEK
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQI 1359
Query: 937 LNKERLLHDEQSTDDSRYKLLES------KLESTLKKSLEIKEEKIAALEARLEESTNYN 990
+ D + + LE+ KL+ L+ + EEK+AA + + T
Sbjct: 1360 ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ 1419
Query: 991 QQL----------RQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1040
Q+L RQ ++K + Q EE+ + S + E ++ E E++E +
Sbjct: 1420 QELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI--SAKYAEERDRAEAEAREKETK 1477
Query: 1041 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1100
L + L E A L+ + +T+++ L + +++ + L++ +L++Q +
Sbjct: 1478 ALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537
Query: 1101 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1160
+TQ +L+ E L + + + L ++ E + + ++ E+ K L++
Sbjct: 1538 KTQLEELEDE---LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKK---QLVRQV 1591
Query: 1161 EKLELLHERQASEYESLISKHGTLKSAHKNLEVE----HRDLEDRYNQLLKQKGQLEDLE 1216
++E E + + ++ L+ K+LE +++ ++ QL K + Q++D
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM 1651
Query: 1217 KML---KVEQEKMLLENKNHE----TVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHK 1269
+ L + +E++L + K +E ++ AE +L E Q +E + L +
Sbjct: 1652 RELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIA 1711
Query: 1270 NLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1329
N + E+ RLEA ++L+E+ ++ + +N++ + K NL+ +D
Sbjct: 1712 NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK-----KANLQ------ID 1760
Query: 1330 QIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLN-ELRRQKEKLEEKIMDQYK 1382
QI T + R+ ++N + RQ +++ N EL+ + +++E + +YK
Sbjct: 1761 QINTDLNLERSHAQKNENA--------RQQLERQNKELKVKLQEMEGTVKSKYK 1806
Score = 156 bits (395), Expect = 2e-37
Identities = 201/981 (20%), Positives = 432/981 (44%), Gaps = 119/981 (12%)
Query: 432 ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS 491
E E +++ EL + +K L E N LT L+ ++ + L + E+L+ +
Sbjct: 844 EEEMMAKEEELVKVREKQLAAE-NRLTEMETLQSQLMAEKL-QLQEQLQAETELCAEAEE 901
Query: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551
++ + Q L + LE + +E++ Q+ Q EK ++++ I+ L E E
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEEEERCQHLQ-------AEKKKMQQNIQELEEQLE- 953
Query: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611
E E Q + Q +++ EA++K +E+E IL + + KL+K EK+
Sbjct: 954 -------EEESARQKL----QLEKVTTEAKLKKLEEEQIILEDQ----NCKLAK---EKK 995
Query: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
++ + + EE L L+ ++E + IT+L+ E++ E++ ELE+
Sbjct: 996 LLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM---ITDLE---ERLRREEKQRQELEKT 1049
Query: 672 NRKLK----KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
RKL+ D L Q+ L+ + ++ +EE VE + A MA ++
Sbjct: 1050 RRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE-EAAQKNMALKKI-- 1106
Query: 728 KELESEKEQLKKGLELLKASFKKTERLEVSY-QGLDIENQRLQKTLENS-------NKKI 779
+ELES+ +L++ LE +AS K E+ + + L+ L+ TL+++ +K+
Sbjct: 1107 RELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE 1166
Query: 780 QQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Q++ + LE E +T + ++E++ S+ +E+L ++ + ++ + LEK K+ LE E
Sbjct: 1167 QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENER 1226
Query: 839 KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRAT 898
L + ++ + G + E+K E + +E V+ E E+ EL + T
Sbjct: 1227 GELANEVKV---------LLQGKGDSEHKRKKVEAQL-QELQVKFNEGERVRTELADKVT 1276
Query: 899 -----IDIKTLVTLREDLVSEKLKT-----QQMNNDLEKLTHELEKIGLNKERLLHDEQS 948
+D T + + D S KL + D ++L E + L+ L +
Sbjct: 1277 KLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVED 1336
Query: 949 TDDSRYKLLESKLES--TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1006
+S + LE + E+ L+K + ++A ++ ++E+S + + + ++K+ E
Sbjct: 1337 EKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396
Query: 1007 LKQRQDE-----ERMVQSSPPISGE------DNKWERESQETTRELLKVKDRLIEVERNN 1055
L QR +E +++ ++ + E D +R+S + K D+L+ E+
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456
Query: 1056 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1115
+ AE++ + E + + + L+L R EQ L+ N + + E L
Sbjct: 1457 SAKYAEER------DRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLM 1510
Query: 1116 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1175
S + +L + +LE + E + + E+L+ + +LE+ + +++E
Sbjct: 1511 SSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE 1570
Query: 1176 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHET 1235
++L+ E++ QL++Q + ++E L+ E+++ + +
Sbjct: 1571 -------------RDLQGRDEQSEEKKKQLVRQ---VREMEAELEDERKQRSMAVAARKK 1614
Query: 1236 VAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1295
+ + K L D N + +K+ LQ K+ L++++ + + A+ + +++
Sbjct: 1615 LEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKK 1674
Query: 1296 YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVE 1355
+ ++ +L + + K ++E L D+I N K +E
Sbjct: 1675 LKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI------------ANSSGKGALALE 1722
Query: 1356 QRQYIDKLNELRRQKEKLEEK 1376
+++ ++ + + +E+LEE+
Sbjct: 1723 EKRRLEA--RIAQLEEELEEE 1741
Score = 124 bits (310), Expect = 1e-27
Identities = 147/710 (20%), Positives = 315/710 (44%), Gaps = 73/710 (10%)
Query: 247 QHLSVELADAKAKIR-------RLRQELEEKTEQLLDCKQELE-QMEIELKRLQQENMNL 298
+ + ELAD K++ L + + K+ +L LE Q++ + LQ+EN
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 299 LSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK---EDNQV 355
LS + + DE ++ RE+ ++ + + + LH A+V ++K ED+
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH------AQVADMKKKMEDSVG 1378
Query: 356 LLET----KTMLEDQLEGTRARSDK----LHELEKENLQLKAKLHDMEMERDMDRKKIEE 407
LET K L+ LEG R ++ +LEK +L+ +L D+ ++ D R+
Sbjct: 1379 CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438
Query: 408 LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
L ++ + + S E ++ + E SL + E + +LE
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKA-ELER 1497
Query: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
N+ +E+L ++ D V + ++EK + L ++VE ++ ++ + + LQ ++
Sbjct: 1498 LNKQFRTEMEDLMSSKDDV---GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDA 1554
Query: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587
K +LE ++ ++ ER ++ ++++E ++ Q+ + R + E
Sbjct: 1555 -------KLRLEVNLQAMKAQFERDLQGRDEQSEE---------KKKQLVRQVREMEAEL 1598
Query: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK 647
E++ S+ + K K+E + + ++ H + +E +L L+ + + ++
Sbjct: 1599 EDERKQRSMAVAARK--KLEMDLKDLEA---HIDSANKNRDEAIKQLRKLQAQMKDCMRE 1653
Query: 648 ITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR 707
+ + + + E+I A +EN +KLK L +L + E+ Q +E EL
Sbjct: 1654 LDDTRASREEILAQAKENE------KKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707
Query: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQR 767
+ + +S K A E + LE+ QL++ LE + + TE + + +++ +
Sbjct: 1708 DEIAN---SSGKGALALEEKRRLEARIAQLEEELEEEQGN---TELINDRLKKANLQIDQ 1761
Query: 768 LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK--ISSKRLEQLEKENKSLEQETS 825
+ L Q+ E+ Q LE +N+ L+ L+E++ + SK + + Q
Sbjct: 1762 INTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEE 1821
Query: 826 QLEKDKKQLEKENKRLRQ-QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
QL+ + K+ + K++R+ + ++KD L+ ++ E+ N K+ ++ RLK
Sbjct: 1822 QLDNETKERQAACKQVRRTEKKLKDVLLQVDD------ERRNAEQYKDQA--DKASTRLK 1873
Query: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934
+L+++ +E + A + L+ +L MN ++ L ++L +
Sbjct: 1874 QLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
Score = 60.1 bits (144), Expect = 2e-08
Identities = 97/424 (22%), Positives = 180/424 (42%), Gaps = 77/424 (18%)
Query: 1039 RELLKVKDRLIEVERNNATLQA-EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1097
R KVK L++V R + A E++ +K + KQL +N + +
Sbjct: 829 RLFTKVKP-LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEME--------------- 872
Query: 1098 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1157
TLQ+Q LM + QL Q L+ E E + E E+L++ +
Sbjct: 873 -TLQSQ-----------------LMAEKLQL---QEQLQAETE-LCAEAEELRARLTA-- 908
Query: 1158 KDHEKLELLHERQAS-EYESLISKHGTLKSAHKNLEVEHRDLEDRY--NQLLKQKGQLED 1214
K E E+ H+ +A E E +H L++ K ++ ++LE++ + +QK QLE
Sbjct: 909 KKQELEEICHDLEARVEEEEERCQH--LQAEKKKMQQNIQELEEQLEEEESARQKLQLEK 966
Query: 1215 L---EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL 1271
+ K+ K+E+E+++LE++N + A+ KKL DR+ + L +E E K+L
Sbjct: 967 VTTEAKLKKLEEEQIILEDQNCK--LAKEKKLL--EDRIAEFTTNLTEEEE----KSKSL 1018
Query: 1272 KSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQI 1331
L N + T LE + ++Q Q+L+ T KL LS L+ + + ++
Sbjct: 1019 AKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ----IAEL 1074
Query: 1332 QTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRR 1391
+ + + L+ + + ++ + K+ EL Q +L+E + +
Sbjct: 1075 KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESE----------- 1123
Query: 1392 RGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLE 1451
K K K+D+ E + T DS+ +L + Q+ + + E
Sbjct: 1124 -----RASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE 1178
Query: 1452 DGQT 1455
+ +T
Sbjct: 1179 EAKT 1182
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 180 bits (457), Expect = 1e-44
Identities = 260/1175 (22%), Positives = 503/1175 (42%), Gaps = 166/1175 (14%)
Query: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE-QMEIELKRLQQENMNLLSDA 302
E + ELA ++A+ R+ELEEK LL K +L+ Q++ E + L
Sbjct: 858 EDFERTKEELARSEAR----RKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLI 913
Query: 303 RSARMYRDELDALREKAVRVDKLESEV-----------SRYKERLHDIEFYKARVEELKE 351
+S + ++ L E+ +++ SE+ S K + D+E +VE+ K
Sbjct: 914 KSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKH 973
Query: 352 --DNQV--LLETKTMLEDQ------------------LEGTRARSDKLHELEKENLQLKA 389
+N+V L E T LE+ L+ + DK++ L K N +L+
Sbjct: 974 ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQ 1033
Query: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS-----RTSELSE 444
+ D+E + ++K +L LE K S + + L + +QI + ELS+
Sbjct: 1034 QTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ 1093
Query: 445 APQKSLGHEVNELTSSRLLK-LEMENQSLTKTVEELRTTVDSVEGNASKILK-MEKENQR 502
K +V+ L + +K L+ + L + +E T +E S + + +E+ ++R
Sbjct: 1094 LQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISER 1153
Query: 503 LSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEH 562
L + +I K+ Q + +DL + Q E T TLR+ + L ++ ++
Sbjct: 1154 LEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN 1213
Query: 563 LNQTVSSL-RQRSQISAE-----ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616
L + L +++S++ E + ++ + K + + + + S+I+ + Q +
Sbjct: 1214 LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL 1273
Query: 617 LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
+ + R + EL H +E E L ++T K + LE+ ++E E +
Sbjct: 1274 IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALT--QQLEELKRQMEEETKAKN 1331
Query: 677 KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
+ ++ + L ++ + E EL+R +L A+ ++AQ + + E +
Sbjct: 1332 AMAHALQSSRHDCDLLREQYEEEQEAKAELQR---ALSKANSEVAQWRTKY-----ETDA 1383
Query: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ-QLESELQDLEMENQT 795
+++ EL +A K +RL+ + + + N + +LE + +++Q ++E ++DLE + T
Sbjct: 1384 IQRTEELEEAKKKLAQRLQEAEENTETANSKCA-SLEKTKQRLQGEVEDLMRDLE-RSHT 1441
Query: 796 LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855
L+ K+ +K +Q+ + + + + +KE++ L + EE
Sbjct: 1442 ACATLD------KKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEV 1495
Query: 856 NVKIGNLEKENKTLSKEIGIYKESCV----RLKELEKENKELVKRATIDIK-TLVTLRED 910
++ L +ENK L +EI E L+E EK K+LV++ D++ L +
Sbjct: 1496 VDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEK-TKKLVEQEKSDLQVALEEVEGS 1554
Query: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNK----ERLLHDEQSTDDSRYKLLESKLES--- 963
L E+ K ++ +L ++ EL++ + K E+L + Q ++ +L++++ S
Sbjct: 1555 LEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND 1614
Query: 964 --TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1021
LKK + E + +E +L S + ++ L+TV+ + + D+
Sbjct: 1615 ALRLKKKM---EGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALR----- 1666
Query: 1022 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA 1081
S ED +K++L VER N L E + +K L+Q E
Sbjct: 1667 --SNED----------------LKEQLAIVERRNGLLLEELEEMKVALEQTE-------- 1700
Query: 1082 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES 1141
+T L EQ + +L L+SQ+TSL+N +L + + E E+
Sbjct: 1701 -------RTRRLSEQELLDASDRVQL------LHSQNTSLINTKKKLEADIAQCQAEVEN 1747
Query: 1142 VIKEREDLKSLYDSLIKDHEKL--ELLHERQASEYESLISKH--GTLKS-AHKNLEVEHR 1196
I+E + + I D + EL E+ S + + K+ T+K H+ E E
Sbjct: 1748 SIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL 1807
Query: 1197 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1256
L+ Q+ K + ++ +LE L VEQ++ AE K H Y +
Sbjct: 1808 ALKGGKKQIQKLENRVRELENELDVEQKR-----------GAEALKGA-------HKYER 1849
Query: 1257 LLKE-TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ 1315
+KE T + DHKN+ L Q ++ +K+K +Q + + N Q +
Sbjct: 1850 KVKEMTYQAEEDHKNILRL-------QDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRR 1902
Query: 1316 LKGNLEE--ENRHLLD-QIQTLMLQNRTLLEQNME 1347
++ LEE E + + Q+ L ++R + Q ME
Sbjct: 1903 VQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
Score = 157 bits (396), Expect = 1e-37
Identities = 212/971 (21%), Positives = 438/971 (45%), Gaps = 133/971 (13%)
Query: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551
K + EKE + + E + E+ + + + + L++EK L+ +++ EN
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETEN--- 901
Query: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611
+ E+ E L +S+I EA+VK+ L E ++E S++ +KR
Sbjct: 902 -LMDAEERCEGL--------IKSKILLEAKVKE-------LTERLEEEEEMNSELVAKKR 945
Query: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
++ + K ++LE L +EKE + K+ NL E++ ALE+ S+L +E
Sbjct: 946 NLEDKCSSLKRD---IDDLELTLTKVEKEKHATENKVKNLS---EEMTALEENISKLTKE 999
Query: 672 NRKL----KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK--CASMKMAQLQL 725
+ L ++TLD + ++ L K N++L+++ +L ++E K A ++ A+ +L
Sbjct: 1000 KKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKL 1059
Query: 726 EN---------KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
E +LE++K+Q++ E LK + +L+ + + + QK ++
Sbjct: 1060 EGDLKMSQESIMDLENDKQQIE---EKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQ 1116
Query: 777 KKIQQLESELQ-------DLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK 829
+I++LE E++ +E + L + LEE+ S+RLE+ ++Q+E
Sbjct: 1117 ARIEELEEEIEAEHTLRAKIEKQRSDLARELEEI---SERLEEASGAT------SAQIEM 1167
Query: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE-LEK 888
+KK+ E E +++R+ ++++ TL ++ L K+ E+G ++ R+K+ LEK
Sbjct: 1168 NKKR-EAEFQKMRR--DLEEATL-QHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEK 1223
Query: 889 ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD--- 945
E EL ++I + + E L K ++ +E E++ + +L+HD
Sbjct: 1224 EKSEL----KMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNM 1279
Query: 946 ------EQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
Q+ + S + L S L KS + +++ L+ ++EE T + L++
Sbjct: 1280 QKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQS 1339
Query: 1000 VKKNYEALKQRQDEER---------MVQSSPPISGEDNKWERESQETTREL----LKVKD 1046
+ + + L+++ +EE+ + +++ ++ K+E ++ + T EL K+
Sbjct: 1340 SRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1399
Query: 1047 RLIEVERNN-------ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS----LQE 1095
RL E E N A+L+ KQ L+ +++ L L ++ + L E
Sbjct: 1400 RLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAE 1459
Query: 1096 QNTTLQTQNAKL---QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL 1152
L A+L Q E+ +L+++ + N +++ Q +L EN+++ +E DL
Sbjct: 1460 WKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQ 1519
Query: 1153 YDSL---IKDHEKLELLHERQASEYE-SLISKHGTLKSAHKNLEVEHRDLE------DRY 1202
+++ EK + L E++ S+ + +L G+L+ H+ ++ LE +
Sbjct: 1520 IAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLE--HEESKILRVQLELSQVKSELD 1577
Query: 1203 NQLLKQKGQLEDL----EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLL 1258
+++++ ++E L ++ + Q + E ++ KK+ G+ LN QL
Sbjct: 1578 RKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGD---LNEMEIQLG 1634
Query: 1259 KETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1318
+ K+L+++ K Q L+ ++ +QL I + E L ++K
Sbjct: 1635 HSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKV 1694
Query: 1319 NLEEENR-------HLL---DQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRR 1368
LE+ R LL D++Q L QN +L+ + + Q + + + E R
Sbjct: 1695 ALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRN 1754
Query: 1369 QKEKLEEKIMD 1379
+EK ++ I D
Sbjct: 1755 AEEKAKKAITD 1765
Score = 99.8 bits (247), Expect = 2e-20
Identities = 137/642 (21%), Positives = 279/642 (43%), Gaps = 75/642 (11%)
Query: 213 ELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTE 272
+ EE++ L A S A S K + EL +AK K+ + QE EE TE
Sbjct: 1350 QYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTE 1409
Query: 273 QLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRY 332
+ +E +RLQ E +L+ D + LD +K DK+ +E +
Sbjct: 1410 ---TANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLD---KKQRNFDKVLAE---W 1460
Query: 333 KERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLH 392
K++L + + A +E +++++ L T L D+L L +EN L+ ++
Sbjct: 1461 KQKLDESQ---AELEAAQKESRSL---STELFKMRNAYEEVVDQLETLRRENKNLQEEIS 1514
Query: 393 DMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH 452
D+ + K ++E E +K E L LE++ + E E+ +
Sbjct: 1515 DLTEQIAETGKNLQE-------AEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL 1567
Query: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512
E++++ S K+ +++ + + + ++++ ++ + RL KK+E N
Sbjct: 1568 ELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLN 1627
Query: 513 EI-VQEKQSLQNCQNLSKDLMKEKAQLEKT----IETLRENSE--RQIKILEQEN----E 561
E+ +Q S + K L + QL+ + + LR N + Q+ I+E+ N E
Sbjct: 1628 EMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLE 1687
Query: 562 HLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH 619
L + +L Q R++ +E + D ++LH + K+E + Q + E+E+
Sbjct: 1688 ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVEN 1747
Query: 620 YKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTL 679
++ AE E +K IT+ + E+++ + ++ LER + L++T+
Sbjct: 1748 SIQESRNAE-------------EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1794
Query: 680 DSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKE-QLK 738
K+L +L+ E+ +LK ++ +L+ +ELE+E + + K
Sbjct: 1795 ---KDLQHRLDEAEQ----------------LALKGGKKQIQKLENRVRELENELDVEQK 1835
Query: 739 KGLELLKASFKKTERL-EVSYQGLDIENQ--RLQKTLENSNKKIQQLESELQDLEMENQT 795
+G E LK + K ++ E++YQ + RLQ ++ K++ + + ++ E + T
Sbjct: 1836 RGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANT 1895
Query: 796 ----LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ 833
++ EL+ +++R + E + L ++ + K +
Sbjct: 1896 QLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 180 bits (456), Expect = 1e-44
Identities = 263/1267 (20%), Positives = 527/1267 (41%), Gaps = 149/1267 (11%)
Query: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL---LSDARSA 305
LSV+L A +I+RL+++ ++ +Q +++ +MEI++K L Q+ L L +AR
Sbjct: 454 LSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGN 513
Query: 306 RMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365
+ RDE + +++S E + +EEL++ NQ LL L +
Sbjct: 514 HVIRDE-----------EVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGE 562
Query: 366 --QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
+ E S K+ EL+ + +L + R + ++ ++ + + Q+
Sbjct: 563 TREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTT 622
Query: 424 DESLHL-GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTT 482
++ L L+ +S L+ P++ + S T +
Sbjct: 623 GVAIPLHASSLDDVS----LASTPKR-------------------PSTSQTVSTPAPVPV 659
Query: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542
++S E +K + + + K E ENE +Q +Q L+ Q DL + + I
Sbjct: 660 IESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ-LEKLQEQVTDLRSQNTK----I 714
Query: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
T + + ++ ++L+ E + ++SL +R+Q A + E+ + + ++ + K
Sbjct: 715 STQLDFASKRYEMLQDNVEGYRREITSLHERNQ-KLTATTQKQEQIINTMTQDLRGANEK 773
Query: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA-- 660
L+ E +KKE E K R + L ++ LL + ++ E+ E
Sbjct: 774 LAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET 833
Query: 661 ---LEQENSELERENRKLKKTLDS--------FKNLTFQLESLEKENSQLD-EENLELRR 708
L + +LE E LKK L++ +NL QL ++ QLD E NL L
Sbjct: 834 KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---QLDTETNLHLNT 890
Query: 709 NVESLKCASMKMAQLQ--LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
E LK A ++A L+ L N E++ + ++ + ++ + + L + + +
Sbjct: 891 K-ELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVN 949
Query: 767 RLQKTLENSNKKIQQ-------LESELQDLEMENQTLQKNLE-ELKISSKRLEQLEKENK 818
L++ L+ S ++Q LE L + + ++KN+E LK S++ QLEK+
Sbjct: 950 DLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLM 1009
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE----IG 874
+E+E +L+ DK++ + + +Q +E+K T N L++ + LS E
Sbjct: 1010 EVEKEKQELQDDKRRAIESME--QQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRD 1067
Query: 875 IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934
+++ + ++ K +EL+ A D++ L +E + Q + +K +L +
Sbjct: 1068 CQEQAKIAVEAQNKYERELMLHAA-DVEALQAAKEQVSKMASVRQHLEETTQKAESQLLE 1126
Query: 935 IGLN---KERLLHDEQSTD-------DSRYKLLESKLESTLKKSL-EIKEEKIAALEARL 983
+ +ER+L DE S + + +LL ++E K + +KE L L
Sbjct: 1127 CKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSL 1186
Query: 984 EESTNYNQQLRQELKTVKK------------NYEALKQRQDEERMVQSSPPISGEDNKWE 1031
E +Q+ + L+ +++ E+L+ RQ E + + + N
Sbjct: 1187 SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER 1246
Query: 1032 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1091
+ Q T + + + ++ + + E N ++ K L+ + ++LE +QA++ L+ +
Sbjct: 1247 EKVQVTAKTMAQHEELMKKTETMNVVMETNKM-LREEKERLEQDLQQMQAKVRKLELDIL 1305
Query: 1092 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN-ESVIKEREDLK 1150
LQE N L ++ LQ E L +N L+ QQ + E ++ E+E
Sbjct: 1306 PLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHT 1365
Query: 1151 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL-------EVEHRDLEDRYN 1203
L E++ L A SL + ++S ++L E +DL+ +
Sbjct: 1366 KRIQQLT---EEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422
Query: 1204 QLLKQKGQLEDLEKM----------LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT 1253
+ ++ + ++K+ LK +Q+K++ + E E L T
Sbjct: 1423 DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482
Query: 1254 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1313
+Q +++ L++ +NL+ L+ + E L+ + +L+ + +L Q E L
Sbjct: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQL 1542
Query: 1314 SQLKGNLEEENR-----------HLLDQIQTLMLQNRTLLEQN---MESKDLFHVE---- 1355
Q EE+ R HL L +N L ++N + KD V
Sbjct: 1543 RQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITAL 1602
Query: 1356 QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQ 1415
+ QY +++ L R+ + +E+ ++Q P+ N + + R++ + ER
Sbjct: 1603 KSQYEGRISRLERELREHQERHLEQ-----RDEPQEPSNKVPEQQRQITLKTTPASGERG 1657
Query: 1416 KSLTLTP 1422
+ T P
Sbjct: 1658 IASTSDP 1664
Score = 160 bits (405), Expect = 1e-38
Identities = 338/1658 (20%), Positives = 669/1658 (40%), Gaps = 276/1658 (16%)
Query: 223 FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE 282
FL S G + ES Q + + + ++ ++ L +T + + ELE
Sbjct: 28 FLADQQSEIDGLKGRHEKFKVESEQ----QYFEIEKRLSHSQERLVNETRECQSLRLELE 83
Query: 283 QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-DKLESE---VSRYKERL-H 337
++ +LK L ++N L + +D A++ + R ++LE+E + R ERL
Sbjct: 84 KLNNQLKALTEKNKEL-------EIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQ 136
Query: 338 DIEFYKARVEELKEDNQVLLETKTML-EDQLEGTRARSDKLHELEKENLQLKAKLHDMEM 396
++E+ E++K N+ L E+ T E QL KL EL+ ++ +K + +E
Sbjct: 137 ELEYL---TEDVKRLNEKLKESNTTKGELQL--------KLDELQASDVSVKYREKRLEQ 185
Query: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE--APQKSLGHEV 454
E+++ L +N L K DE L LG E + +E+ E ++ EV
Sbjct: 186 EKEL-------LHSQNTWLNTELKTKTDELLALGRE-----KGNEILELKCNLENKKEEV 233
Query: 455 NELTSSRLLKLEMENQSLTKTVEELRTTV-DSVEGNASKILKMEKE---NQRLSKKVEIL 510
+ L ++ L+ N+ L K VE+L T + ++ E AS K E + +LS +
Sbjct: 234 SRL-EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSA 292
Query: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI-------ETLRENSERQ----IKILEQE 559
++ + L L+KE + K I E ++ E++ I LE+E
Sbjct: 293 ADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE 352
Query: 560 NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH 619
E+ N +S+ +++ I +E + ++ T++ ++KI
Sbjct: 353 LENANDLLSATKRKGAILSEEEL-----------AAMSPTAAAVAKI------------- 388
Query: 620 YKEKGERAEELENELHHLEKENELLQKKITNLKIT---CEKIEALEQENSELERENRKLK 676
+ G + EL N ++E +++LL +K+ N +I E ++ +E + L+R+ + +
Sbjct: 389 -VKPGMKLTELYNA--YVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYE 445
Query: 677 KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
+ + +L+ +LE KE +L E+ + A+ + + L+ +N+ +E + +
Sbjct: 446 RAQKAVASLSVKLEQAMKEIQRLQEDTDK----------ANKQSSVLERDNRRMEIQVKD 495
Query: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI--QQLES--ELQDLEME 792
L + + +L ++ V I ++ + +S+ ++ Q L S +++L+ +
Sbjct: 496 LSQQIRVLLMELEEARGNHV------IRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
Query: 793 NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852
NQ L L EL + +R EQ +K E + +LE +LE+ K + Q ++ D+ +
Sbjct: 550 NQRLLVALRELGETREREEQETTSSKITELQL-KLESALTELEQLRKSRQHQMQLVDSIV 608
Query: 853 EE-----------------------NNVKIGNLEKENKTL-------------SKEIGIY 876
+ ++V + + K T S E
Sbjct: 609 RQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEA 668
Query: 877 KESCVRLKEL-EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI 935
K + +L+E+ E KE + I + L L+E + + + +++ L+ + E +
Sbjct: 669 KAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEML 728
Query: 936 GLNKERLLHDEQSTDDSRYKLL-----ESKLESTLKKSLEIKEEKIAALEARLEESTNYN 990
N E + S + KL + ++ +T+ + L EK+A E R E
Sbjct: 729 QDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEK 788
Query: 991 QQLR-QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1049
+ L+ E++ ++ L +++ + ++ + I G ER ET + L
Sbjct: 789 EMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQG---ILERSETETKQRLSS------ 839
Query: 1050 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN--AKL 1107
++E+ + K+ L+ +++Q T NL Q+L +RQ + E N L T+
Sbjct: 840 QIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDT--ETNLHLNTKELLKNA 897
Query: 1108 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH 1167
Q E +TL L N Q+ Q S + + +ED+ L L + E++ L
Sbjct: 898 QKEIATLKQH---LSNMEVQVASQSSQRTGKGQP--SNKEDVDDLVSQLRQTEEQVNDLK 952
Query: 1168 ER------QASEYESLI-SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1220
ER +Y++++ S +L + E +++E R + + + QLE +K+++
Sbjct: 953 ERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLE--KKLME 1010
Query: 1221 VEQEKMLLENKNHETVAAEYKKLCGENDRL----NHTYSQLLKETEVLQTDHKNLKSLLN 1276
VE+EK L++ + + ++L L N L + + L + + +
Sbjct: 1011 VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQE 1070
Query: 1277 NSKL---EQTRLEAEF-----------------SKLKEQYQQLDITSTKLNNQCELLSQL 1316
+K+ Q + E E SK+ Q L+ T+ K +Q L +
Sbjct: 1071 QAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ---LLEC 1127
Query: 1317 KGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
K + EE R L D++ + + L +QN L Q EKL +K
Sbjct: 1128 KASWEERERMLKDEVSKCVCRCEDLEKQN------------------RLLHDQIEKLSDK 1169
Query: 1377 IMDQYKFYDPSP------PRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEG 1430
++ K P + L++ + I+ +K+I R + + R
Sbjct: 1170 VVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVE 1229
Query: 1431 FLQLPHQDSQDSSSVGSNSLE-DGQTLG-----TKKSSTMNDLVQSMVLAGQWTGSTENL 1484
L+ Q+ QDS + ++ +T+ KK+ TMN ++++ + + E L
Sbjct: 1230 LLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLRE---EKERL 1286
Query: 1485 EVPDDISTGKRRK-ELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVS 1543
E K RK EL + N S ++++ + +D ++ + VS
Sbjct: 1287 EQDLQQMQAKVRKLELDILPLQEA--NAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
Query: 1544 DDSS----------TGSRVHASRPASL--DSGRTSTSNSNNNASLHEVKAGAVNNQSRPQ 1591
+ VH R L + GR + +NASL NNQ+ Q
Sbjct: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASL-------TNNQNLIQ 1397
Query: 1592 SHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIK------- 1644
S + + E + I ++ + ++ ++ KI ++++ ++K
Sbjct: 1398 SLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVK-KIGRRYKTQYEELKAQQDKVM 1456
Query: 1645 ------TGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKP 1698
+G + V++Q+ E L + KS S E+ ++ + K+LS +
Sbjct: 1457 ETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQE 1516
Query: 1699 VSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDT 1736
+ L +S + D DR T + + + K E T
Sbjct: 1517 QTVQLQSELS-RLRQDLQDRTTQEEQLRQQITEKEEKT 1553
Score = 146 bits (369), Expect = 2e-34
Identities = 240/1148 (20%), Positives = 480/1148 (41%), Gaps = 195/1148 (16%)
Query: 404 KIEELMEENMTLEMAQKQSMDESL---HLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
K+ + ++ + +A +QS + L H +++E + E+ + S VNE
Sbjct: 16 KLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETREC 75
Query: 461 RLLKLEMEN-----QSLTKTVEELRTTVDSVEGNASKILKMEKE-----------NQRLS 504
+ L+LE+E ++LT+ +EL D S+ + ++E N+RLS
Sbjct: 76 QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLS 135
Query: 505 KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564
+++E L ++ + + L+ +L + +L+ + +++ +R LEQE E L+
Sbjct: 136 QELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR----LEQEKELLH 191
Query: 565 QTVSSLRQRSQISA-EARVKDIEKENKILHE--SIKETSSKLSKIEFEKRQIKKELEHY- 620
+ L + E EK N+IL +++ ++S++E + +K EH
Sbjct: 192 SQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQ 251
Query: 621 ----------KEKGERAEELENELHHLEKENEL-LQKKITNL-KITCEKIEALEQENSEL 668
KE E+ +E + H NEL K++NL K + EA E +
Sbjct: 252 KHVEDLLTKLKEAKEQQASMEEKFH-----NELNAHIKLSNLYKSAADDSEAKSNELTRA 306
Query: 669 ERENRKL-KKTLDSFKNLTFQLESLEKENSQLDEENLE----LRRNVESLK--CASMKMA 721
E KL K+ ++ K + L +E+ Q+++E LE L + +E+ ++ K
Sbjct: 307 VEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRK 366
Query: 722 QLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD------IENQRLQKTLENS 775
L +EL + +++K K TE + D +EN+R+ K L+
Sbjct: 367 GAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEI 426
Query: 776 NKKIQQLESELQDLEMENQTLQKNLEELKI----SSKRLEQLEKENKSLEQETSQLEKDK 831
K+++ L+ E + QK + L + + K +++L+++ +++S LE+D
Sbjct: 427 VKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDN 486
Query: 832 KQLEKENKRLRQQAEIKDTTLEE---------NNVKIGNLEKENKTLSKEIGIYKESCVR 882
+++E + K L QQ + LEE V ++ ++ +S+ + Y+
Sbjct: 487 RRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR----N 542
Query: 883 LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL 942
++EL+++N+ L LV LRE +G +ER
Sbjct: 543 IEELQQQNQRL----------LVALRE-------------------------LGETRER- 566
Query: 943 LHDEQSTDDSRYKLLESKLESTLKKSLEI---KEEKIAALEARLEESTNYNQQLRQELKT 999
+EQ T S+ L+ KLES L + ++ ++ ++ +++ + + Y L Q
Sbjct: 567 --EEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGV 624
Query: 1000 V---------KKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1050
+ + +R + V + P+ ++ E++ ++L ++ + +
Sbjct: 625 AIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKK 684
Query: 1051 VERNNATLQAEK-QALKTQLKQLETQNNNLQAQILALQRQTVSLQE-------QNTTLQT 1102
+ N +Q E+ + L+ Q+ L +QN + Q+ ++ LQ+ + T+L
Sbjct: 685 EKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHE 744
Query: 1103 QNAKL----QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK 1158
+N KL Q + +N+ + L N +L + + EN L K
Sbjct: 745 RNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAEN------------------LKK 786
Query: 1159 DHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK--GQLEDLE 1216
+ E L+L R + + ESL+++ NL+ LE R KQ+ Q+E LE
Sbjct: 787 EKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILE-RSETETKQRLSSQIEKLE 845
Query: 1217 KMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLN 1276
+ ++K+ E + T+ + +L T QL ET + H N K LL
Sbjct: 846 HEISHLKKKLENEVEQRHTLTRNL------DVQLLDTKRQLDTETNL----HLNTKELLK 895
Query: 1277 NSKLEQTRLEAEFSKLKEQY----------------QQLDITSTKLNNQCELLSQLKGNL 1320
N++ E L+ S ++ Q + +D ++L E ++ LK L
Sbjct: 896 NAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERL 955
Query: 1321 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID-KLNELRRQKEKLEEKIMD 1379
+ + ++Q Q ++ T LE+++ + E R+ I+ +L E + +LE+K+M+
Sbjct: 956 KTSTSN-VEQYQAMV----TSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLME 1010
Query: 1380 QYKFYD--PSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ 1437
K RR + ++ +L K+ + E Q++L T + Q +
Sbjct: 1011 VEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNE----QQARR 1066
Query: 1438 DSQDSSSV 1445
D Q+ + +
Sbjct: 1067 DCQEQAKI 1074
Score = 130 bits (327), Expect = 1e-29
Identities = 190/929 (20%), Positives = 402/929 (43%), Gaps = 135/929 (14%)
Query: 164 THNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHF 223
T QE + + ++ +++ L + + L E++ + + LS++R+ L
Sbjct: 753 TQKQEQIINTMTQDLRGANEK-----LAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLA 807
Query: 224 LPHASS----SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQ------ 273
+ + Q+ G TE++Q LS ++ + +I L+++LE + EQ
Sbjct: 808 EQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTR 867
Query: 274 -----LLDCKQELE----------------QMEIELKRLQQENMNLL----SDARSARMY 308
LLD K++L+ Q EI + NM + S R+ +
Sbjct: 868 NLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQ 927
Query: 309 RDELDALREKAVRVDKLESEVSRYKERLH----DIEFYKARV----EELKEDNQVLLETK 360
+ + + ++ + E +V+ KERL ++E Y+A V E L ++ QV E +
Sbjct: 928 PSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVR 987
Query: 361 TMLEDQL----EGTRARSDKLHELEKENLQL----KAKLHDMEMERDMDRKKIEELMEE- 411
+E +L E KL E+EKE +L + + ME + +K + + E
Sbjct: 988 KNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEV 1047
Query: 412 ---------NMTLEMAQKQSMDESLHLGWELE-QISRTSELSEAPQKSLG---HEVNELT 458
++ E ++ E + E + + R L A ++L +V+++
Sbjct: 1048 QEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMA 1107
Query: 459 SSRLLKLEMENQSLTKTVE-------ELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
S R E ++ ++ +E R D V + +EK+N+ L ++E L
Sbjct: 1108 SVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS 1167
Query: 512 NEIVQE-KQSLQNCQNLS---------------KDLMKEKAQLEKTIETLRENSER---Q 552
+++V K+ +Q N+S + + +EK E E + S R +
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQR 1227
Query: 553 IKILEQENEHLNQTVSSLRQRSQISAE--ARVKDIEKENKILHESIKETSSKLSKIEFEK 610
+++LE+E + L ++++ R++ Q++A+ A+ +++ K+ + ++ + ET+ L + EK
Sbjct: 1228 VELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNV-VMETNKMLRE---EK 1283
Query: 611 RQIKKELEHYKEKGERAE-----------ELENELHHLEKENELLQKKITNLKITCEKIE 659
+++++L+ + K + E EL + L+ E +LL++ + K + +
Sbjct: 1284 ERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLV 1343
Query: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK 719
+ +Q++ + E + L + K + E + + +++ N L N ++
Sbjct: 1344 S-QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKED 1402
Query: 720 MAQLQLEN----KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775
+ +++ E K+L+++ +++ ++ + K R + Y+ L + ++ +T S
Sbjct: 1403 LNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQS 1462
Query: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835
+ Q+ +Q+++ +TL + + K ++E L+K E E L++ QL+
Sbjct: 1463 SGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQ 1522
Query: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL----KELEKENK 891
E RLRQ +++D T +E ++ EKE KT K I K L +L KEN+
Sbjct: 1523 SELSRLRQ--DLQDRTTQEEQLRQQITEKEEKT-RKAIVAAKSKIAHLAGVKDQLTKENE 1579
Query: 892 ELVKRATIDIKTLVTLREDLVSEKLKT--QQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
EL +R + ++D + ++ Q + +L EL + ++ER L
Sbjct: 1580 ELKQR-----NGALDQQKDELDVRITALKSQYEGRISRLERELRE---HQERHLEQRDEP 1631
Query: 950 DDSRYKLLESKLESTLKKSLEIKEEKIAA 978
+ K+ E + + TLK + E IA+
Sbjct: 1632 QEPSNKVPEQQRQITLKTTPASGERGIAS 1660
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 178 bits (452), Expect = 4e-44
Identities = 235/1019 (23%), Positives = 443/1019 (43%), Gaps = 134/1019 (13%)
Query: 278 KQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-LREKAVRVDKLESEVSRYKERL 336
K ELE ++ +L++L++EN N R + E+ A L E + KLESE+ E L
Sbjct: 413 KSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEIL 472
Query: 337 HDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHE------LEKENLQLKAK 390
D ELK E + + ++E +R L + L++E K+
Sbjct: 473 RDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSY 532
Query: 391 LHDMEMERDMDRK-------KIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT---- 439
L +M +++ + +L+ + +++A K++ + LH Q+S++
Sbjct: 533 LSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITC 592
Query: 440 ---------SELSEAPQKSLGHEVNELTSSRLL-----KLEMENQSLTKTVEELRTTVDS 485
S L P K GH+V E + + E E Q L +EELRT +
Sbjct: 593 NDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQ 652
Query: 486 VEGNAS--KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE 543
+E S K+ + +Q + E+LE K + + S+ L EK QLE+ I
Sbjct: 653 IEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEK-QLEEKIV 711
Query: 544 TLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKL 603
+ + + LEQE N+ + SL E EK KI E KE ++
Sbjct: 712 AYSSIAAKNAE-LEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQI 770
Query: 604 SKIEFEKRQIKKELEHYKEKGERAEELENEL----HHLEKENELL-----QKKITNLKIT 654
++E Q++K+ + +KE+ + L+ ++ HHLE + LL + K N+K
Sbjct: 771 ERLE---AQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKD 827
Query: 655 CEKIEALEQENSELERENRKLKKTLDSFKN-LTFQLESLEKENSQLDEENLELRRNVESL 713
E ++AL+ + SE + R+L L+ K L L LE + +++ L++ E +
Sbjct: 828 -EALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQ---LKKKSEEV 883
Query: 714 KCASMKMAQLQLENKELESEKEQ-------LKKGLELLKASFKKTERLEVSYQGLDIE-- 764
C +L+++N L+ EQ L++ ++L+ + LE + L+ +
Sbjct: 884 YCLQK---ELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVS 940
Query: 765 --NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR----LEQLEKENK 818
Q LQK E+S +K++++E + + E ++ + EL ++++ ++Q ++E
Sbjct: 941 KLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELS 1000
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878
+E+E L++D + +L + T LE+ + LEK + E+ E
Sbjct: 1001 KMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETEL---TE 1057
Query: 879 SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN 938
+ + + LE E + ++ L LR+ L +L ++ ++ LT EL + +
Sbjct: 1058 ALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKME 1117
Query: 939 ----KERLLHDEQSTDDSRYKLLES-----------------------KLESTLKKS-LE 970
K+ LL +Q+ + ++L + KLE TL+KS LE
Sbjct: 1118 IEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELE 1177
Query: 971 IKE---------EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMV---- 1017
+KE +K+ + +L E Q QE+ +KK E +QR E V
Sbjct: 1178 LKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQ 1237
Query: 1018 ------QSSPPIS-GEDNKWERES-QETTRELLKVKDRLIEVERNNATLQAEKQALKTQL 1069
Q I G++ + RE Q + EL + + + ++ +R L +E + +K
Sbjct: 1238 EQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLS 1297
Query: 1070 KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS----QSTSLMNQN 1125
K+ + N+L ++ A + + L+ + +Q + KL E +L + S +
Sbjct: 1298 KEKDAHGNHLAEELGASKVREAHLEAR---MQAEIKKLSAEVESLKEAYHMEMISHQENH 1354
Query: 1126 AQLLI----QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISK 1180
A+ I Q+SS++ NE + K + +L+ D++ H++++ +E + E+L++K
Sbjct: 1355 AKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTK 1413
Score = 169 bits (429), Expect = 2e-41
Identities = 240/1128 (21%), Positives = 477/1128 (42%), Gaps = 163/1128 (14%)
Query: 176 MEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPC 235
+E +E +E L N KRL ER ++ +E+ +E+ L L +++ +
Sbjct: 381 LEKVQAEEEILERNLTNCEKENKRL-QERCGLYKSELEILKEK--LRQLKEENNNGKEKL 437
Query: 236 GSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD------------------- 276
+K +E + +L +++ I +L ELE K E L D
Sbjct: 438 RIMAVKNSE----VMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQN 493
Query: 277 -----CKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSR 331
C+QE+E +EL+ L EK + L+ E+
Sbjct: 494 ERLDLCQQEIESSRVELRSL-------------------------EKIISQLPLKRELFG 528
Query: 332 YKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKL 391
+K L Y+ KED + + ++L L++K +
Sbjct: 529 FKSYLSK---YQMSSFSNKEDRCI-----------------GCCEANKLVISELRIKLAI 568
Query: 392 HDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451
+ E+++ + N+T + +SL + ++ S+ S L P K G
Sbjct: 569 KEAEIQK----------LHANLT-----ANQLSQSLITCNDSQESSKLSSLETEPVKLGG 613
Query: 452 HEVNELTSSR-----LLKLEMENQSLTKTVEELRTTVDSVEGNAS--KILKMEKENQRLS 504
H+V E + + E E Q L +EELRT + +E S K+ + +Q
Sbjct: 614 HQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQL 673
Query: 505 KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564
+ E+LE K + + S+ L EK QLE+ I + + + LEQE N
Sbjct: 674 IQEELLEKASNSSKLESEMTKKCSQLLTLEK-QLEEKIVAYSSIAAKNAE-LEQELMEKN 731
Query: 565 QTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG 624
+ + SL E EK KI E KE ++ ++E Q++K+ + +KE+
Sbjct: 732 EKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLE---AQLEKKDQQFKEQE 788
Query: 625 ERAEELENEL----HHLEKENELL-----QKKITNLKITCEKIEALEQENSELERENRKL 675
+ L+ ++ HHLE + LL + K N+K E ++AL+ + SE + R+L
Sbjct: 789 KTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMK-KDEALKALQNQVSEETIKVRQL 847
Query: 676 KKTLDSFK-NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
L+ K L L LE + ++ +L++ E + C +L+++N L+
Sbjct: 848 DSALEICKEELVLHLNQLEGNKEKFEK---QLKKKSEEVYCL---QKELKIKNHSLQETS 901
Query: 735 EQ-------LKKGLELLKASFKKTERLEVSYQGLDIE----NQRLQKTLENSNKKIQQLE 783
EQ L++ ++L+ + LE + L+ + Q LQK E+S +K++++E
Sbjct: 902 EQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKME 961
Query: 784 SELQDLEMENQTLQKNLEELKISSKR----LEQLEKENKSLEQETSQLEKDKKQLEKENK 839
+ + E ++ + EL ++++ ++Q ++E +E+E L++D +
Sbjct: 962 EKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLS 1021
Query: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATI 899
+L + T LE+ + LEK + E+ E+ + + LE E +
Sbjct: 1022 QLDMILDQTKTELEKKTNAVKELEKLQHSTETEL---TEALQKREVLETELQNAHGELKS 1078
Query: 900 DIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGL----NKERLLHDEQSTDDSRYK 955
++ L LR+ L +L ++ ++ LT EL + + K+ LL +Q+ + ++
Sbjct: 1079 TLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWE 1138
Query: 956 LLE-----SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ- 1009
L + + L+ T+++ E+KI LE LE+S ++ ++++++ + K+
Sbjct: 1139 LKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQ 1198
Query: 1010 -RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1068
R+ E M+Q+ IS + ++E + T + + +++ + E E+ AT E L +
Sbjct: 1199 LREKEFIMLQNEQEIS----QLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQE 1254
Query: 1069 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1128
L+ Q N ++ + Q V Q + L ++ ++ + ++ L +
Sbjct: 1255 LRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGAS 1314
Query: 1129 LIQQSSLENENESVIK----EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1184
++++ LE ++ IK E E LK Y + H+ E A S S+ ++
Sbjct: 1315 KVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQ------ENHAKWKISADSQKSSV 1368
Query: 1185 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKN 1232
+ ++ LE +LE+ + + Q++D ++++ E +L + +N
Sbjct: 1369 QQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGEN 1416
Score = 165 bits (417), Expect = 4e-40
Identities = 271/1175 (23%), Positives = 514/1175 (43%), Gaps = 169/1175 (14%)
Query: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIEL-------KRLQQENMNLLSDA--- 302
L +A+ K+ + ++ + EK + L + K+E +++++L KR +++ L +A
Sbjct: 307 LREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEEL 366
Query: 303 -RSARMYRDELDALREKAVRVDKL--------ESEVSRYKERL----HDIEFYKARVEEL 349
++ + Y+ ++ EK +++ E E R +ER ++E K ++ +L
Sbjct: 367 SKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQL 426
Query: 350 KEDN-------------------------QVLLETKTMLEDQLEGTRARSDKLHELEKEN 384
KE+N Q +L+ ++ LE++ E R DK L EN
Sbjct: 427 KEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILR---DKF-SLMNEN 482
Query: 385 LQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISR--TSEL 442
+LK ++ D+ +++IE E +LE Q + G++ +S+ S
Sbjct: 483 RELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFK-SYLSKYQMSSF 541
Query: 443 SEAPQKSLG-HEVNELTSSRL-LKLEME---------NQSLTKTVEELRTTVDSVEGNAS 491
S + +G E N+L S L +KL ++ N + + + L T DS E +S
Sbjct: 542 SNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQE--SS 599
Query: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551
K+ +E E +L V E QN ++K KE+ +L IE LR
Sbjct: 600 KLSSLETEPVKLG-------GHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELR----T 648
Query: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611
++ +E EN L ++ + Q+ E ++ +K+ E K+ S L+ ++
Sbjct: 649 KLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTL----EK 704
Query: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
Q+++++ Y + ELE EL +EK NE ++ TN+ EKI L E ++
Sbjct: 705 QLEEKIVAYSSIAAKNAELEQEL--MEK-NEKIRSLETNINTEHEKI-CLAFEKAK---- 756
Query: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
K L+ K + Q+E LE +QL++++ + + E K SM + + LE
Sbjct: 757 ----KIHLEQHKEMEKQIERLE---AQLEKKDQQFK---EQEKTMSMLQQDIICKQHHLE 806
Query: 732 SEKEQL--KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESEL--- 786
S L KG E+ K + KK E L+ ++NQ ++T+ K++QL+S L
Sbjct: 807 SLDRLLTESKG-EMKKENMKKDEALKA------LQNQVSEETI-----KVRQLDSALEIC 854
Query: 787 -QDLEMENQTLQKNLE----ELKISSKRLEQLEKE----NKSLEQETSQLEKDKKQLEKE 837
++L + L+ N E +LK S+ + L+KE N SL QETS+ + ++
Sbjct: 855 KEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSL-QETSEQNVILQHTLQQ 913
Query: 838 NKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCV-RLKELEKENKELVKR 896
+++ QQ I++ LE+ K LEK+ L +E+ +ES +L+++E++ +
Sbjct: 914 QQQMLQQETIRNGELEDTQTK---LEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHE 970
Query: 897 ATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE---LEKIGLNKERLLHDEQSTDDSR 953
A + + ++ L K++ Q +L K+ E L++ G NK L D
Sbjct: 971 ADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQT 1030
Query: 954 YKLLESKLEST-----LKKSLEIK-EEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL 1007
LE K + L+ S E + E + E E N + +L+ L+ +++ + L
Sbjct: 1031 KTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVL 1090
Query: 1008 KQRQ-DEERMVQSSPPISGEDNKWERESQETTRELLK----VKDRLIEVERNNATLQAEK 1062
++ Q E + ++ E + + E ++ +ELL+ +K+R E+++ A +
Sbjct: 1091 QKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLD 1150
Query: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1122
++ ++E + L+ L++ + L+E N +++ N KLQ L + ++
Sbjct: 1151 MTIREHRGEMEQKIIKLEG---TLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIML 1207
Query: 1123 NQNAQLLIQQSSLE------NENESVIKERED-LKSLYDSLIKDHEKLELLHERQASEYE 1175
++ + +E E ESV+KE+E + + Y I ++L L E+ + +
Sbjct: 1208 QNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHT 1267
Query: 1176 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQ--EKMLLENKNH 1233
L A + +E +LED +KQ + +D E+ + E
Sbjct: 1268 ELAEARHQQVQAQREIERLSSELED-----MKQLSKEKDAHGNHLAEELGASKVREAHLE 1322
Query: 1234 ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1293
+ AE KKL E + L Y E Q +H K ++ K +L + K K
Sbjct: 1323 ARMQAEIKKLSAEVESLKEAYHM---EMISHQENHAKWKISADSQKSSVQQLNEQLEKAK 1379
Query: 1294 EQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL 1328
+ ++ T + L+ Q + +++ +E N LL
Sbjct: 1380 LELEEAQDTVSNLHQQVQDRNEV---IEAANEALL 1411
Score = 146 bits (369), Expect = 2e-34
Identities = 253/1147 (22%), Positives = 480/1147 (41%), Gaps = 147/1147 (12%)
Query: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQI-SRTSELSEAPQKSLGHEVNELTSS 460
R+K+ +L ++N L M + + +EL Q ++ S L A Q++ + E
Sbjct: 235 REKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILE---E 291
Query: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520
+++ LE E + K + E ++ S+K+ I + + +QE S
Sbjct: 292 QIINLEAEVSAQDKVLREAENKLEQ------------------SQKMVIEKEQSLQE--S 331
Query: 521 LQNCQNLSKDLMKEKAQLEKTIETLRE---NSERQIKILEQENEHLNQTVSSLRQRSQIS 577
+ C L DL+++ Q ++ E N+E K +Q + + + + ++ +I
Sbjct: 332 KEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEI- 390
Query: 578 AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----GERAEELENE 633
E + + EKENK L E S+L ++ + RQ+K+E + KEK + E+ +
Sbjct: 391 LERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQ 450
Query: 634 LHHLEKENELLQKKITNLKITCEKIEALEQENSELE----RENRKLKKTLDSFKNLTFQL 689
L + L+ ++ N +L EN EL+ +N +L ++ +L
Sbjct: 451 LTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVEL 510
Query: 690 ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE----SEKEQLKKGLELLK 745
SLEK SQ L L+R + K K NKE E +L +K
Sbjct: 511 RSLEKIISQ-----LPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIK 565
Query: 746 ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTL--QKNLEEL 803
+ K+ E+ ++ +L ++L N Q S+L LE E L + E +
Sbjct: 566 LAIKEA---EIQKLHANLTANQLSQSLITCND--SQESSKLSSLETEPVKLGGHQVAESV 620
Query: 804 KISSKRL--EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861
K ++ +Q EKE + L +L Q+E EN L+ + T + ++
Sbjct: 621 KDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLK--VNMAHRTSQFQLIQEEL 678
Query: 862 LEKENKTLSKEIGIYKESCVRLKELEKENKE-LVKRATIDIKTLVTLREDLV--SEKLKT 918
LEK + + E + K+ C +L LEK+ +E +V ++I K L ++L+ +EK+++
Sbjct: 679 LEKASNSSKLESEMTKK-CSQLLTLEKQLEEKIVAYSSIAAKN-AELEQELMEKNEKIRS 736
Query: 919 QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAA 978
+ N + E HE + K + +H EQ + E++I
Sbjct: 737 LETNINTE---HEKICLAFEKAKKIHLEQHKE---------------------MEKQIER 772
Query: 979 LEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQET 1037
LEA+LE+ +QQ +++ KT+ + + +Q E + + GE K + E
Sbjct: 773 LEAQLEKK---DQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEA 829
Query: 1038 TRELL-KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096
+ L +V + I+V + ++ L+ K+ L L QLE + Q+ + LQ++
Sbjct: 830 LKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKE 889
Query: 1097 ----NTTLQTQNAKLQVENSTLNSQSTSLMNQ---NAQLLIQQSSLENENESVIKE-RED 1148
N +LQ + + + TL Q L + N +L Q+ LE + + +E ++
Sbjct: 890 LKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQ 949
Query: 1149 LKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQ 1208
+S + L K EK E + + +I GT + ++ +L +++
Sbjct: 950 RESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHL 1009
Query: 1209 KGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT----YSQLLKETEVL 1264
K E+ K + + Q M+L+ +T + E ++L H+ ++ L++ EVL
Sbjct: 1010 KRDGEN--KAMHLSQLDMILDQT--KTELEKKTNAVKELEKLQHSTETELTEALQKREVL 1065
Query: 1265 QTD----HKNLKSLLNN-------SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1313
+T+ H LKS L + Q LE +++ +K+ +L ++ ++ + L
Sbjct: 1066 ETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQEL 1125
Query: 1314 SQLKGNLEEENRHLLDQIQTL-------------MLQNRTLLEQNMESKDLFHVEQRQYI 1360
++ L+E N L + + M Q LE +E +L E + I
Sbjct: 1126 LEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQI 1185
Query: 1361 DKLNE-LRRQKEKLEEK----IMDQYKFYDPSPPRRRGNWITLKMRKLIKS--------- 1406
+ LN+ L+ KE+L EK + ++ + R +M ++K
Sbjct: 1186 ESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQY 1245
Query: 1407 KKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVG--SNSLEDGQTLGTKKSSTM 1464
K+ I+ ++ LT ++ +E + HQ Q + S+ LED + L +K +
Sbjct: 1246 KEAIDLGQELRLTREQVQNSHTE-LAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHG 1304
Query: 1465 NDLVQSM 1471
N L + +
Sbjct: 1305 NHLAEEL 1311
Score = 126 bits (316), Expect = 2e-28
Identities = 191/884 (21%), Positives = 376/884 (42%), Gaps = 99/884 (11%)
Query: 547 ENSERQIKILEQENEHLNQTVSSLRQRSQI---SAEARVKDIEKENKILHESIKETSSKL 603
E+S + E E L V+SLR +I S ++ +++ + + S+
Sbjct: 120 ESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRS 179
Query: 604 SKIEFEKRQIKKELEHY-------KEKGERAEELENELHHLEKENELLQKKITNLKITCE 656
K+ + + L +Y K G + + + + + ++I +L+ E
Sbjct: 180 EKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLR---E 236
Query: 657 KIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRR-------- 708
K+ L Q+N+ L +N L + F+++ F+L + S L+ +
Sbjct: 237 KLNKLRQQNACLVTQNHSL---MTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQI 293
Query: 709 -NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK----KTERLEVSYQGLDI 763
N+E+ A K+ + + ENK +S+K ++K L ++ + K + LE + QG
Sbjct: 294 INLEAEVSAQDKVLR-EAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRA 352
Query: 764 ENQR---------LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLE 814
E QR L K + KK+ + +L+ ++ E + L++NL + +KRL++
Sbjct: 353 ERQRNEALYNAEELSKAFQQYKKKVAE---KLEKVQAEEEILERNLTNCEKENKRLQERC 409
Query: 815 KENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIG 874
KS E L++ +QL++EN +++ I E ++ + L E+
Sbjct: 410 GLYKS---ELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELE 466
Query: 875 IYKESCVRLK-ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELE 933
K+ +R K L EN+EL R + L ++++ S +++ + + + +L + E
Sbjct: 467 -NKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRE 525
Query: 934 KIGLNKERLLHDEQSTDDSRYKLL-----ESKLESTLKKSLEIKEEKIAALEARLEESTN 988
G + S + + + + S L+ L IKE +I L A L +
Sbjct: 526 LFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTAN-- 583
Query: 989 YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1048
QL Q L T + E+ K E V+ E K ++Q T +
Sbjct: 584 ---QLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVK--DQNQHTMNK-------- 630
Query: 1049 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1108
+ E+ L + L+T+L Q+E +N++L+ + Q +QE+ + ++KL+
Sbjct: 631 -QYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLE 689
Query: 1109 VENSTLNSQSTSLMNQNAQLLIQQSSLENEN----ESVIKEREDLKSLYDSLIKDHEKLE 1164
E + SQ +L Q + ++ SS+ +N + ++++ E ++SL ++ +HEK+
Sbjct: 690 SEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKIC 749
Query: 1165 LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQE 1224
L E+ + HK +E + LE QL K+ Q ++ EK + + Q+
Sbjct: 750 LAFEKAKKIH----------LEQHKEMEKQIERLE---AQLEKKDQQFKEQEKTMSMLQQ 796
Query: 1225 KMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH----KNLKSLLNNSK- 1279
++ + + E++ + GE + N + LK + ++ + L S L K
Sbjct: 797 DIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKE 856
Query: 1280 ---LEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN---RHLLDQIQT 1333
L +LE K ++Q ++ L + ++ + E+N +H L Q Q
Sbjct: 857 ELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQ-QQ 915
Query: 1334 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
MLQ T+ +N E +D ++Q EL++Q+E EK+
Sbjct: 916 QMLQQETI--RNGELEDTQTKLEKQVSKLEQELQKQRESSAEKL 957
Score = 71.6 bits (174), Expect = 7e-12
Identities = 157/784 (20%), Positives = 332/784 (42%), Gaps = 139/784 (17%)
Query: 731 ESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790
++E+E L + L+ K TE S Q L E + + ENS+ SE L+
Sbjct: 130 DNEEESLLANVASLRHELKITEW---SLQSLGEELSSVSPS-ENSDYAPNPSRSEKLILD 185
Query: 791 ME-------NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843
++ N + +N+ KIS + +K + ++ ++++ K L ++ +LRQ
Sbjct: 186 VQPSHPGLLNYSPYENV--CKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQ 243
Query: 844 QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT 903
Q T K ++ E +S ++ LE ++ A++ I
Sbjct: 244 QNACLVTQNHSLMTKFESIHFE----------LTQSRAKVSMLESAQQQ---AASVPI-- 288
Query: 904 LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLES 963
L E +++ + + + L + ++LE+ +++ ++ EQS +S+ + ++ K++
Sbjct: 289 ---LEEQIINLEAEVSAQDKVLREAENKLEQ---SQKMVIEKEQSLQESKEECIKLKVD- 341
Query: 964 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ--RQDEERMVQSSP 1021
L E T ++ ++ N E L + +Q ++++ +
Sbjct: 342 -------------------LLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLE 382
Query: 1022 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN--L 1079
+ E+ ER +E ++++R ++E + LK +L+QL+ +NNN
Sbjct: 383 KVQAEEEILERNLTNCEKENKRLQERC-------GLYKSELEILKEKLRQLKEENNNGKE 435
Query: 1080 QAQILALQRQTVSLQEQNTTLQTQNAKLQVEN-STLNSQSTSLMNQNAQLLI----QQSS 1134
+ +I+A++ V Q + + ++EN + SLMN+N +L + Q
Sbjct: 436 KLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNER 495
Query: 1135 LENENESVIKEREDLKSLYDSLIKDHEKLEL------LHERQASEYES------------ 1176
L+ + + R +L+SL + + K EL L + Q S + +
Sbjct: 496 LDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEAN 555
Query: 1177 -LISKHGTLKSAHKNLEVE--HRDL-EDRYNQLLKQKGQLEDLEKMLKVEQEKMLL---- 1228
L+ +K A K E++ H +L ++ +Q L ++ K+ +E E + L
Sbjct: 556 KLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQ 615
Query: 1229 -----ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1283
+++N T+ +Y+K E RL +L T+++Q + +N ++ K+
Sbjct: 616 VAESVKDQNQHTMNKQYEK---ERQRLVTGIEEL--RTKLIQIEAEN-----SDLKVNMA 665
Query: 1284 RLEAEFSKLKEQYQQLDITSTKLNNQ----CELLSQLKGNLEEE-------NRHLLDQIQ 1332
++F ++E+ + S+KL ++ C L L+ LEE+ + Q
Sbjct: 666 HRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQ 725
Query: 1333 TLMLQNRTL--LEQNMESKD-----LFHVEQRQYIDKLNELRRQKEKLE---EKIMDQYK 1382
LM +N + LE N+ ++ F ++ ++++ E+ +Q E+LE EK Q+K
Sbjct: 726 ELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFK 785
Query: 1383 FYDPSPPRRRGNWITLKM------RKLIKSKKDINRER-QKSLTLTPTRSDSSEGFLQLP 1435
+ + + + I + R L +SK ++ +E +K L ++ SE +++
Sbjct: 786 EQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVR 845
Query: 1436 HQDS 1439
DS
Sbjct: 846 QLDS 849
Score = 52.4 bits (124), Expect = 4e-06
Identities = 97/414 (23%), Positives = 172/414 (41%), Gaps = 50/414 (12%)
Query: 1082 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQST----------SLMNQNAQLLIQ 1131
+I +L+ + L++QN L TQN L + +++ + T S Q A + I
Sbjct: 230 EIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPIL 289
Query: 1132 QSSLENENESVIKEREDLKSLYDSLIKDHEK-LELLHERQASEYESLISKHGTLKSAHKN 1190
+ + N V + + L+ + L + + +E Q S+ E + K L+ +
Sbjct: 290 EEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQG 349
Query: 1191 LEVEHRDLEDRYN--QLLK--QKGQLEDLEKMLKVEQEKMLLENK--NHETVAAEYKKLC 1244
E + E YN +L K Q+ + + EK+ KV+ E+ +LE N E
Sbjct: 350 KRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEK--------- 400
Query: 1245 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA-----EFSKLKEQYQQL 1299
EN RL E E+L+ + LK NN K E+ R+ A ++L E Q +
Sbjct: 401 -ENKRLQERCGLYKSELEILKEKLRQLKEENNNGK-EKLRIMAVKNSEVMAQLTESRQSI 458
Query: 1300 DITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQY 1359
++L N+ E+L K +L ENR L ++ + L +Q +ES VE R
Sbjct: 459 LKLESELENKDEILRD-KFSLMNENRELKVRV-AAQNERLDLCQQEIESS---RVELRSL 513
Query: 1360 IDKLNELRRQKEKLEEK-IMDQYKFYDPSPPRRR------GNWITLKMRKLIKSKKDINR 1412
+++L ++E K + +Y+ S R N + + ++ K I
Sbjct: 514 EKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISE---LRIKLAIKE 570
Query: 1413 ERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMND 1466
+ L T + S+ + DSQ+SS + S E + G + + ++ D
Sbjct: 571 AEIQKLHANLTANQLSQSLITC--NDSQESSKLSSLETEPVKLGGHQVAESVKD 622
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 177 bits (450), Expect = 6e-44
Identities = 250/1091 (22%), Positives = 486/1091 (44%), Gaps = 135/1091 (12%)
Query: 227 ASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEI 286
ASS + P + + T SR + A ++ +E ++ EQLL +++LE+ E+
Sbjct: 323 ASSVSSRPSRTGLLTETSSRYARKISGTTA---LQEALKEKQQHIEQLL-AERDLERAEV 378
Query: 287 -----ELKRLQQENMNLLSDARSARMYRDE--LDALREKAVRVDK----LESEVSRYKER 335
+ ++QE + L D + E +D LR D+ L +++ K +
Sbjct: 379 AKATSHVGEIEQE-LALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRK 437
Query: 336 LHDIEFYKARVEELKEDNQVLLETKTMLED----QLEGT----RARSDKLH-ELEKENLQ 386
+ D++F RVEE + + LET+T LE +LE + + ++DKL ELE +
Sbjct: 438 VEDLQF---RVEE-ESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVA 493
Query: 387 -LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQS-MDESLHLGWELEQISRTSELSE 444
+ K ME+E+D+ +++E+ E LE + +D SL L L++IS E E
Sbjct: 494 TVSEKSRIMELEKDL-ALRVQEVAELRRRLESNKPAGDVDMSLSL---LQEISSLQEKLE 549
Query: 445 APQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV-EGNASKILKMEKENQRL 503
+ E+ L ++ K ++ L T + + + N S K+E N+
Sbjct: 550 VTRTDHQREITSLKEH----FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKEN 605
Query: 504 SKKVEI----LENEIVQEKQSLQNCQ-NLSKDLMKEKAQ---LEKTIETLRENSERQIKI 555
S + + LE I +Q+++ + + SK L E A+ L+ IE +R + + +I+
Sbjct: 606 SDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIEN 665
Query: 556 LEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR-QIK 614
L+ + + ++ + ++ + A+ EKEN S++ SKL K E + +++
Sbjct: 666 LQNQQD--SERAAHAKEMEALRAKLMKVIKEKEN-----SLEAIRSKLDKAEDQHLVEME 718
Query: 615 KELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKI---EALEQENSELERE 671
L +E + +ELE ++ +++ + LK T EK+ +AL + +SE + E
Sbjct: 719 DTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSE 778
Query: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCAS---------MKMAQ 722
+KL++ QLE+ EK+ ++LE+ +N ES K +S +K+
Sbjct: 779 MKKLRQ----------QLEAAEKQI-----KHLEIEKNAESSKASSITRELQGRELKLTN 823
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
LQ E+ KE L+K L++LK F + VS Q + +Q+T+ ++K +Q
Sbjct: 824 LQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ------RSMQETVNKLHQKEEQF 877
Query: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK----DKKQLEKEN 838
DLE + L + + +R EQL K + LE + +++ K + QL K N
Sbjct: 878 NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMN 937
Query: 839 KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRAT 898
LR +K+ +EE +K+ + L K I ++ V+ ++ ++E +
Sbjct: 938 DELR----LKERDVEELQLKLTKANENASFLQKSI---EDMTVKAEQSQQEAAK------ 984
Query: 899 IDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLE 958
K ++ +LE+ +LEK K H++ +RY+
Sbjct: 985 ------------------KHEEEKKELERKLSDLEK----KMETSHNQCQELKARYERAT 1022
Query: 959 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1018
S+ ++ ++ L+ ++ + E +L+ + N L QEL+ ++K + K Q E +Q
Sbjct: 1023 SETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQ 1082
Query: 1019 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN 1078
++ E + ++T + K+++ L ++ NN E K L +
Sbjct: 1083 IMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEE 1142
Query: 1079 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTS---LMNQNAQLLIQQSSL 1135
+ +I L++ +Q + LQ +N KL E + TS L + + L Q +
Sbjct: 1143 FRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEM 1202
Query: 1136 ENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEH 1195
+ IK+ ++ K+ SL K L + +E E L ++ L+ + + + H
Sbjct: 1203 KKRESKFIKDADEEKA---SLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLH 1259
Query: 1196 RDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC-GENDRLNHTY 1254
++ + +K + ++++LE LK + ++ + N +T A E ++ + D LN
Sbjct: 1260 SVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVI 1319
Query: 1255 SQLLKETEVLQ 1265
L ++ + L+
Sbjct: 1320 VDLQRKNQDLK 1330
Score = 159 bits (401), Expect = 3e-38
Identities = 240/1095 (21%), Positives = 470/1095 (42%), Gaps = 149/1095 (13%)
Query: 147 GLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPL-LKNMALHLKRLIDE-- 203
GL +T + A I T QE + + Q +++ D+E + H+ + E
Sbjct: 334 GLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA 393
Query: 204 --RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIR 261
RD H + ++EL + D L + E+ VEL + + +
Sbjct: 394 LARDGHDQHVLELEAKMDQLRTM------------------VEAADREKVELLNQLEEEK 435
Query: 262 RLRQELEEKTEQLLDCKQELE-QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAV 320
R ++L+ + E+ K +LE Q ++E R+++ +LL + A + EL+ R V
Sbjct: 436 RKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQRELEDTRVATV 495
Query: 321 ----RVDKLESEVSRYKERLHDIEFYKARVEELKEDNQV-----LLETKTMLEDQLEGTR 371
R+ +LE +++ R+ ++ + R+E K V LL+ + L+++LE TR
Sbjct: 496 SEKSRIMELEKDLAL---RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTR 552
Query: 372 ARSDKLHELEKENLQLKAKLHDMEM------------ERDMDRKKIEELMEENMTLEMAQ 419
+ KE+ + + H E+ E + + K+E +EN +
Sbjct: 553 TDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALW 612
Query: 420 KQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL--TKTVE 477
K ++ ++ EL + K LG E E LK ++E L +E
Sbjct: 613 KSKLETAI-----ASHQQAMEELKVSFSKGLGTETAEFAE---LKTQIEKMRLDYQHEIE 664
Query: 478 ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQ 537
L+ DS +K +ME +L K ++ EN + + L ++ + +
Sbjct: 665 NLQNQQDSERAAHAK--EMEALRAKLMKVIKEKENSLEAIRSKLDKAED------QHLVE 716
Query: 538 LEKTIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQISA-EARVKDIEKENKILHES 595
+E T+ L+E +E ++K LE N+ + SQ+ A E ++ D++ K E
Sbjct: 717 MEDTLNKLQE-AEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG 775
Query: 596 IKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQK---KITNLK 652
E ++E ++QIK + +A + EL E + LQ+ +++ +K
Sbjct: 776 KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 835
Query: 653 ITCEK-IEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
T EK ++ L+++ +E E +++++ N +L E++ + L + +LR N
Sbjct: 836 ETLEKELQILKEKFAEASEEAVSVQRSMQETVN---KLHQKEEQFNMLSSDLEKLREN-- 890
Query: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ--RLQ 769
+A ++ + +E + +EQL K E L + + E+ D +Q ++
Sbjct: 891 --------LADMEAKFREKDEREEQLIKAKEKL-----ENDIAEIMKMSGDNSSQLTKMN 937
Query: 770 KTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ-----LEKENKSLEQET 824
L + +++L+ +L LQK++E++ + +++ +Q E+E K LE++
Sbjct: 938 DELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKL 997
Query: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL----SKEIGIYKESC 880
S LEK + + + L+ + E + + + +I L+ KTL K G +E+
Sbjct: 998 SDLEKKMETSHNQCQELKARYERATSETKTKHEEI--LQNLQKTLLDTEDKLKGAREENS 1055
Query: 881 VRLKELEKENKELVK-RATIDIKTLVTLREDLVSEKLKT-----------QQMNNDLEKL 928
L+ELE+ K+ K +A + + + E + EK +T ++ N+L+ L
Sbjct: 1056 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1115
Query: 929 TH----ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLE---IKEEKIAALE- 980
+E++ +KE L + Q ++ R K +E+ ++ +KS + ++EE + E
Sbjct: 1116 KENNLKNVEELNKSKELLTVENQKMEEFR-KEIETLKQAAAQKSQQLSALQEENVKLAEE 1174
Query: 981 -ARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTR 1039
R + +Q+L +E + N + L+ ++ E + ++ + E+ ++S T
Sbjct: 1175 LGRSRDEVTSHQKLEEERSVL--NNQLLEMKKRESKFIKD----ADEEKASLQKSISITS 1228
Query: 1040 ELLKVKDRLIEVERNNAT-----------LQAEKQALKTQLKQLETQNNNLQAQILALQR 1088
LL KD +E RN T L + Q L++ +LE + NL+ Q+ +R
Sbjct: 1229 ALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKR 1288
Query: 1089 QTVSLQEQNTTLQTQNAKLQVEN-STLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1147
Q S T ++ + Q LNS L +N L + +E +E+ +
Sbjct: 1289 QLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDL---KMKVEMMSEAALNGNG 1345
Query: 1148 DLKSLYDSLIKDHEK 1162
D + YDS D EK
Sbjct: 1346 DDLNNYDS--DDQEK 1358
Score = 114 bits (285), Expect = 9e-25
Identities = 136/608 (22%), Positives = 274/608 (45%), Gaps = 64/608 (10%)
Query: 247 QHLSVELADAKAKIRRLRQELEEK-------TEQLLDCKQELEQMEIELKRLQQENMNLL 299
+HL +E +K + +EL+ + E L + Q E +E EL+ L+++
Sbjct: 794 KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 853
Query: 300 SDARSA-RMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLE 358
+A S R ++ ++ L +K + + L S++ + +E L D+E A+ E E + L++
Sbjct: 854 EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADME---AKFREKDEREEQLIK 910
Query: 359 TKTMLEDQL-EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEM 417
K LE+ + E + D +L K N +L+ K ERD++ ++ +L + N
Sbjct: 911 AKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK------ERDVEELQL-KLTKANENASF 963
Query: 418 AQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE 477
QK +E ++ +E S+ E + +L LE + ++ +
Sbjct: 964 LQK-----------SIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 1012
Query: 478 ELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN---EIVQEKQSLQNCQNLSKDLMKE 534
EL+ + ++ +K EIL+N ++ + L+ + + L++E
Sbjct: 1013 ELKARYE------------RATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQE 1060
Query: 535 KAQLEKTIETLR--ENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVK-DIEKENKI 591
+L K + + + +E ++I+EQ + +T++SL Q +A+ + + D KEN +
Sbjct: 1061 LEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL 1120
Query: 592 LHESIKETSSKLSKIEFEK-RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITN 650
+ S +L +E +K + +KE+E K + A + +L L++EN L +++
Sbjct: 1121 KNVEELNKSKELLTVENQKMEEFRKEIETLK---QAAAQKSQQLSALQEENVKLAEELGR 1177
Query: 651 LKITCEKIEALEQENSELERENRKLKKTLDSF-KNLTFQLESLEKENS-------QLDEE 702
+ + LE+E S L + ++KK F K+ + SL+K S + D E
Sbjct: 1178 SRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAE 1237
Query: 703 NLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTER-LEVSYQGL 761
+LR V L+ + L + LES+K +L+ ++ L+ K+ +R L S
Sbjct: 1238 LEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNT 1297
Query: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821
D + ++ E+ +I L S + DL+ +NQ L+ +E + ++ + N +
Sbjct: 1298 DTQADEDERAQES---QIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSD 1354
Query: 822 QETSQLEK 829
+ Q +K
Sbjct: 1355 DQEKQSKK 1362
Score = 86.7 bits (213), Expect = 2e-16
Identities = 203/1019 (19%), Positives = 408/1019 (40%), Gaps = 149/1019 (14%)
Query: 768 LQKTLENSNKKIQQL--ESELQDLEMENQT--LQKNLEELKISSKRLEQ--LEKENKSLE 821
LQ+ L+ + I+QL E +L+ E+ T + + +EL ++ +Q LE E K +
Sbjct: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
Query: 822 QETSQLEKDKKQLEKENKRLRQQAEIKDTT--LEENNVKIGNLEKENKTLSKEIGIYKES 879
T D++++E N+ ++ +++D +EE ++ G+LE + K
Sbjct: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKL----------E 462
Query: 880 CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNK 939
R+KELE+ +A + L R VSEK + ++ DL E+ ++
Sbjct: 463 HARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAEL---- 518
Query: 940 ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
R L + D L + S+L++ LE+ L+E ++ Q K
Sbjct: 519 RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQ--KE 576
Query: 1000 VKKNYEALKQRQDEERMVQSSPPISGEDNK-----WERESQETTRELLKVKDRL-IEVER 1053
+K Y A ++ E ++S + ++N W+ + + + + L + +
Sbjct: 577 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 636
Query: 1054 NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1113
T AE LKTQ++++ L Q + +LQ Q + + +AK ++E
Sbjct: 637 GLGTETAEFAELKTQIEKMR----------LDYQHEIENLQNQQDSERAAHAK-EMEALR 685
Query: 1114 LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1173
+N+ I+ + E++ +++ + L L ++ IK E LE+L + +
Sbjct: 686 AKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE-LEVLQAKCNEQ 744
Query: 1174 YESLISKHGTLKSAHK---NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK-VEQEKMLLE 1229
+ + + LK+ + +L+ + + +++ K + QLE EK +K +E EK
Sbjct: 745 TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEK---- 800
Query: 1230 NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSL--------------- 1274
N ++ ++L G +L + L + ++V +T K L+ L
Sbjct: 801 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 860
Query: 1275 ------------------LNNSKLEQTR-----LEAEFSKLKEQYQQLDITSTKLNNQCE 1311
+ +S LE+ R +EA+F + E+ +QL KL N
Sbjct: 861 RSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA 920
Query: 1312 LLSQLKGNLEEENRHLLDQIQ-------------TLMLQNRTLLEQNMESKDLFHVEQRQ 1358
+ ++ G+ + + D+++ T +N + L++++E + + +Q
Sbjct: 921 EIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 980
Query: 1359 YIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMR-----KLIKSK-KDINR 1412
K +E +K++LE K+ D K + S LK R K+K ++I +
Sbjct: 981 EAAKKHE--EEKKELERKLSDLEKKMETS----HNQCQELKARYERATSETKTKHEEILQ 1034
Query: 1413 ERQKSL-----TLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSTMNDL 1467
QK+L L R ++S +L Q + + + ED + + + +
Sbjct: 1035 NLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTET 1094
Query: 1468 VQSMVLAGQWTGSTE---------NLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSA 1518
+ S+ Q + NL+ ++++ K + T+ +A
Sbjct: 1095 LASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAA 1154
Query: 1519 GFRSKQL--VNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASL 1576
+S+QL + ++ E++ G S D T + L+ R+ +N
Sbjct: 1155 AQKSQQLSALQEENVKLAEEL---GRSRDEVTSHQ-------KLEEERSVLNNQLLEMKK 1204
Query: 1577 HEVK--AGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISE 1634
E K A ++ Q S +LL + +A + + L+ + S+ L H + +
Sbjct: 1205 RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSL-HSVVQ 1263
Query: 1635 TLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFL 1693
TLES K++ E+ Q E +L+S S + + DE ++ DFL
Sbjct: 1264 TLESDKVKLELKVKNLEL----QLKENKRQLSS---SSGNTDTQADEDERAQESQIDFL 1315
Score = 62.8 bits (151), Expect = 3e-09
Identities = 120/518 (23%), Positives = 205/518 (39%), Gaps = 104/518 (20%)
Query: 91 QETLQQL--IMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEF------I 142
QE L ++ + +L L I K F+E E V + QK+E+F +
Sbjct: 825 QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL 884
Query: 143 ERIQG--LDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLK-NMALHLKR 199
E+++ D + K +E + + E+ MS ++ L K N L LK
Sbjct: 885 EKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK- 943
Query: 200 LIDERDEHSETIIELSEERDGLHFLPHA----SSSAQSPCGSPGMKRTESRQHLSVELAD 255
ERD E ++L++ + FL + + A+ K E ++ L +L+D
Sbjct: 944 ---ERDVE-ELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD 999
Query: 256 A--------------KAKIRRLRQELEEKTEQLLDCKQE-LEQMEIELKRLQQENMNLLS 300
KA+ R E + K E++L Q+ L E +LK ++EN LL
Sbjct: 1000 LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ 1059
Query: 301 DARSARMYRDELDALR--EKAVRV----------------------DKLESEVSRYKER- 335
+ R D+ A + E A+++ KL++E+ KE
Sbjct: 1060 ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENN 1119
Query: 336 LHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDME 395
L ++E E L +NQ + E + +E + +S +L L++EN++L +L
Sbjct: 1120 LKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSR 1179
Query: 396 MERDMDRKKIEEL-MEENMTLEMAQKQSM---DESLHLGWELEQISRTSEL--------- 442
E +K EE + N LEM +++S D + IS TS L
Sbjct: 1180 DEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1239
Query: 443 -----------SEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA- 490
A KSL H V + S +KLE++ ++L ++E + + S GN
Sbjct: 1240 KLRNEVTVLRGENASAKSL-HSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTD 1298
Query: 491 ------------------SKILKMEKENQRLSKKVEIL 510
S I+ ++++NQ L KVE++
Sbjct: 1299 TQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM 1336
Score = 50.8 bits (120), Expect = 1e-05
Identities = 76/380 (20%), Positives = 152/380 (40%), Gaps = 58/380 (15%)
Query: 162 EVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHL----KRLIDERDEHSETIIELSEE 217
E +HNQ ++ T ++ E +L+N+ L +L R+E+S + EL E
Sbjct: 1005 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1064
Query: 218 R-------------DGLHFLPHASSSAQSPCGS-PGMKRTESRQHLSV------------ 251
R D + + + S K+T ++ +
Sbjct: 1065 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1124
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
EL +K + Q++EE +++ KQ Q +L LQ+EN+ L +E
Sbjct: 1125 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL----------AEE 1174
Query: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKAR-VEELKEDNQVLLETKTMLEDQLEGT 370
L R++ KLE E S +L +++ +++ +++ E+ L ++ ++ L
Sbjct: 1175 LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEK 1234
Query: 371 RARSDKLHE----LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDES 426
A +KL L EN K+ LH + + D+ K+ EL +N+ L++ + +
Sbjct: 1235 DAELEKLRNEVTVLRGENASAKS-LHSVVQTLESDKVKL-ELKVKNLELQLKENKR---- 1288
Query: 427 LHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSV 486
+L S ++ + + +S ++ L+ +NQ L VE + ++
Sbjct: 1289 -----QLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEA--AL 1341
Query: 487 EGNASKILKMEKENQRLSKK 506
GN + + ++Q K
Sbjct: 1342 NGNGDDLNNYDSDDQEKQSK 1361
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 177 bits (449), Expect = 8e-44
Identities = 222/1132 (19%), Positives = 468/1132 (41%), Gaps = 137/1132 (12%)
Query: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMY-RDELDALRE 317
K +E+ E+ K+EL + E + K L+++ + L+ + ++ + E DAL +
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904
Query: 318 KAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL 377
R D+L + + ++ ++ R E+ +E N L K LED+ + D L
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVT---ERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 961
Query: 378 H----ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWEL 433
++EKE + K+ ++ E + I +L +E L+ A +Q++D+ L E
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD---LQMEE 1018
Query: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME------------------------- 468
++++ ++ ++ + L + L +++E
Sbjct: 1019 DKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQ 1078
Query: 469 --NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526
N+ L K E+ +E + ++++K+ + L ++E LE EI E+ S +
Sbjct: 1079 QLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEK 1138
Query: 527 LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE 586
DL +E ++ + +E + QI++ ++ + L + S + EA +
Sbjct: 1139 QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE-STLQHEATAAALR 1197
Query: 587 KENKILHESIKETSSKLSKIEFEKRQIKKELEHYK----EKGERAEELENELHHLEKENE 642
K++ +S+ E ++ ++ K++++KE K + E + + EK
Sbjct: 1198 KKHA---DSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCR 1254
Query: 643 LLQKKITNLKITCEK----IEALEQENSELERENRKLKKTLDSFKNLTFQL--------E 690
L+ +++ +K E+ I L + + L E+ + + LD + QL +
Sbjct: 1255 TLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQ 1314
Query: 691 SLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA---- 746
+E+ QL+EE +L+ A L+ + +E + K +L++G+ +
Sbjct: 1315 QIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQ 1374
Query: 747 --------SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
+ ++TE LE + ++L + L+++ + ++ + S+ LE Q LQ
Sbjct: 1375 WRTKYETDAIQRTEELEEA-------KKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQN 1427
Query: 799 NLEELKISSKRLEQ----LEKENKSLE-------QETSQLEKDKKQLEKENKRLRQQAEI 847
+E+L I +R L+K+ ++ + Q+ + + + + +KE++ L +
Sbjct: 1428 EVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFK 1487
Query: 848 KDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVR----LKELEKENKELVKRATIDIKT 903
EE+ + L++ENK L +EI E + ELEK K+L + +
Sbjct: 1488 VKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTS 1547
Query: 904 LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLES 963
L L E+ K ++ +L ++ E+++ K+ L + + ++S L++
Sbjct: 1548 LEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDA 1607
Query: 964 TLKK---SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS 1020
++ +L IK++ L + + N+Q + L+ ++ LK Q +
Sbjct: 1608 EIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQ-----LHLD 1662
Query: 1021 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1080
I G+D+ +K++L VER +QAE + L+ L++ E +
Sbjct: 1663 DAIRGQDD---------------LKEQLAMVERRANLMQAEVEELRASLERTERGRKMAE 1707
Query: 1081 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1140
++L + L QNT+L KL+ + S + + ++ + N E
Sbjct: 1708 QELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQE----------ARNAEE 1757
Query: 1141 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL-EVEHRDLE 1199
K D + + L K+ + L ER E T+K L E E L+
Sbjct: 1758 KAKKAITDAAMMAEELKKEQDTSAHL-ERMKKNMEQ------TVKDLQLRLDEAEQLALK 1810
Query: 1200 DRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1259
Q+ K + ++ +LE ++ EQ+ + K K+L + + +L
Sbjct: 1811 GGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQD 1870
Query: 1260 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK----LKEQYQQLDITSTKLN 1307
+ LQT K K ++ + A+F K L+E ++ DI +++N
Sbjct: 1871 LVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVN 1922
Score = 161 bits (407), Expect = 6e-39
Identities = 213/1032 (20%), Positives = 451/1032 (43%), Gaps = 111/1032 (10%)
Query: 149 DFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHS 208
D D A +++ H EN +V ++++E + L + +A K ++ H
Sbjct: 957 DIDDLELTLAKVEKEKHATEN-------KVKNLTEE-MAGLDETIAKLTKEKKALQEAHQ 1008
Query: 209 ETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELE 268
+T+ +L E D ++ L A + + E + L ++L AK R+L +L+
Sbjct: 1009 QTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGS-LEQEKKLCMDLERAK---RKLEGDLK 1064
Query: 269 EKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELD-ALREKAVRVDKLES 327
E +D + + +Q+ +LK+ + E NL + +L ++E R+++LE
Sbjct: 1065 LAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEE 1124
Query: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQL 387
E+ + +A+ E+ + D LE + ++LE + E+ K
Sbjct: 1125 EIEAERAS-------RAKAEKQRSDLSRELEE---ISERLEEAGGATSAQIEMNK----- 1169
Query: 388 KAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQ 447
K + +M RD++ E ++ T +K+ D LG +++ + R + E +
Sbjct: 1170 KREAEFQKMRRDLE----ESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEK 1225
Query: 448 KSLGHEVNELTSS--RLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL--------KME 497
L E+N+L S+ + K + + + +T+E+ + + + E +++ ++
Sbjct: 1226 SELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLH 1285
Query: 498 KENQRLSKKV---EILENEIVQEKQSL-QNCQNLSKDLMKE---KAQLEKTIETLRENSE 550
E+ S+++ + + +++ + KQ+ Q + L + L +E K+ L +++ R + +
Sbjct: 1286 TESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCD 1345
Query: 551 RQIKILEQENE----------HLNQTVSSLRQRSQISAEARVKDIEKENKIL-------H 593
+ E+E E N V+ R + + A R +++E+ K L
Sbjct: 1346 LLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1405
Query: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKI 653
E ++ +SK + +E K++++ E+E ER+ L+K+ K + K
Sbjct: 1406 EHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNA---ACIALDKKQRNFDKVLAEWKQ 1462
Query: 654 TCEKIEA-LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712
E+ +A LE E + +L K ++++ LE+L++EN L +E +L E
Sbjct: 1463 KYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDL---TEQ 1519
Query: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
+ + +L+ K+L+ EK +L+ LE +AS + E + Q L +
Sbjct: 1520 IAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQ------LELNQVK 1573
Query: 773 ENSNKKIQQLESELQDLEMEN----QTLQKNLE-ELKISSKRLEQLEKENKSLEQETSQL 827
++KI + + EL L+ + +++Q L+ E++ + L +K L + QL
Sbjct: 1574 SEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQL 1633
Query: 828 EKDKKQLEKENKRLRQ-QAEIKDTTL---------EENNVKIGNLEKENKTLSKEIGIYK 877
+Q + + LR Q +KDT L ++ ++ +E+ + E+ +
Sbjct: 1634 NHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELR 1693
Query: 878 ESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQ----QMNNDLEKLTHELE 933
S R + K ++ + A+ ++ L T L++ K K + Q+ ++E + E
Sbjct: 1694 ASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEAR 1753
Query: 934 KIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQL 993
++ + D + K E + L++ + E+ + L+ RL+E+ +QL
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKK--EQDTSAHLERMKKNMEQTVKDLQLRLDEA----EQL 1807
Query: 994 RQELKTVKKNYEALKQRQDE-ERMVQSSPPISGED----NKWERESQETTRELLKVKDRL 1048
LK KK + L+ R E E V+S + E K ER +E T + + + +
Sbjct: 1808 --ALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNI 1865
Query: 1049 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1108
+ ++ LQ + +A K Q ++ E Q+N A+ LQ + +E+ ++Q KL+
Sbjct: 1866 LRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLR 1925
Query: 1109 VENSTLNSQSTS 1120
V++ ++++ S
Sbjct: 1926 VKSREVHTKVIS 1937
Score = 134 bits (336), Expect = 1e-30
Identities = 174/878 (19%), Positives = 380/878 (43%), Gaps = 137/878 (15%)
Query: 511 ENEIVQEKQSLQNC-QNLSKDLMKEKAQLEKTIETLRENSERQIKI------LEQENEHL 563
E E+ K+ + + L+K K K EK + ++E ++ Q+++ L E
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERC 909
Query: 564 NQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK 623
+Q + +++I EA++K++ + + E E ++K K+E E ++KK+++
Sbjct: 910 DQLI-----KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID----- 959
Query: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683
+LE L +EKE + K+ NL E++ L++ ++L +E + L+ ++ +
Sbjct: 960 -----DLELTLAKVEKEKHATENKVKNLT---EEMAGLDETIAKLTKEKKALQ---EAHQ 1008
Query: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENK---ELESEKEQLKKG 740
L+ E + + L + +L + V+ L+ L+ E K +LE K +L+
Sbjct: 1009 QTLDDLQMEEDKVNTLTKAKTKLEQQVDDLE------GSLEQEKKLCMDLERAKRKLEGD 1062
Query: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800
L+L + S TE + Q+L + L+ ++ L+ +++D + LQK +
Sbjct: 1063 LKLAQESTMDTEN----------DKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKI 1112
Query: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
+EL+ R+E+LE+E ++ ++ EK + L +E + + ++
Sbjct: 1113 KELQA---RIEELEEEIEAERASRAKAEKQRSDLSRELEEISER---------------- 1153
Query: 861 NLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
LE+ S +I + K+ R E +K ++L + T LR+ + +
Sbjct: 1154 -LEEAGGATSAQIEMNKK---REAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE 1209
Query: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALE 980
+ L+++ +LEK + S K+ + L S + E ++ +
Sbjct: 1210 QIDSLQRVKQKLEK---------------EKSELKMEINDLASNM--------ETVSKAK 1246
Query: 981 ARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1040
A E+ + E+KT + ++++R++ +S + + ES E +R+
Sbjct: 1247 ANFEKMCRTLEDQLSEIKT---------KEEEQQRLINE---LSAQKARLHTESGEFSRQ 1294
Query: 1041 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1100
L + + ++ R + + LK QL++ + L + + + L+EQ
Sbjct: 1295 LDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEE 1354
Query: 1101 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS-LENENESVIKEREDLKSLYDSLIKD 1159
Q A+LQ S NS+ + IQ++ LE + + + +D + +++
Sbjct: 1355 QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414
Query: 1160 HEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML 1219
LE +R +E E L+ +A L+ + R+ + L + K + E+ + L
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFD---KVLAEWKQKYEETQAEL 1471
Query: 1220 KVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSK 1279
+ Q+ E + L E ++ + Y + L E L+ ++KNL+ +++
Sbjct: 1472 EASQK--------------ESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLT 1517
Query: 1280 LEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNR 1339
+ +L++ +QLD ++L L + + +LE E +L +IQ + Q +
Sbjct: 1518 EQIAEGGKHIHELEKVKKQLDHEKSELQTS---LEEAEASLEHEEGKIL-RIQLELNQVK 1573
Query: 1340 TLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
+ +++ + KD ++L++L+R ++ E +
Sbjct: 1574 SEIDRKIAEKD----------EELDQLKRNHLRVVESM 1601
Score = 71.6 bits (174), Expect = 7e-12
Identities = 113/559 (20%), Positives = 228/559 (40%), Gaps = 90/559 (16%)
Query: 1033 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1092
+S ET +E+ +K+ + + A +A+++ L+ ++ L + N+LQ Q+ A
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904
Query: 1093 LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL 1152
+E+ L +L+ + + ++ NA+L ++ LE+E + K+ +DL+
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 964
Query: 1153 YDSLIKD----HEKLELLHERQASEYES---LISKHGTLKSAHKNLEVEHRDLEDRYNQL 1205
+ K+ K++ L E A E+ L + L+ AH+ + + ED+ N L
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTL 1024
Query: 1206 LKQKGQLE----DLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET 1261
K K +LE DLE L+ E KKLC + +R LK
Sbjct: 1025 TKAKTKLEQQVDDLEGSLEQE------------------KKLCMDLERAKRKLEGDLKLA 1066
Query: 1262 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE 1321
+ D +N K L N KL++ E +S L+G +E
Sbjct: 1067 QESTMDTENDKQQL-NEKLKKKEFE--------------------------MSNLQGKIE 1099
Query: 1322 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY 1381
+E + L Q+Q + + + +E+ E + + + + ++L R+ E++ E++
Sbjct: 1100 DE-QALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL---- 1154
Query: 1382 KFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQD 1441
T ++ K ++ ++ ++ L + + +++ L+ H DS
Sbjct: 1155 ---------EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVA 1205
Query: 1442 SSSVGSNSLED-GQTLGTKKSS---TMNDLVQSMVLAGQWTGSTENL--EVPDDISTGKR 1495
+SL+ Q L +KS +NDL +M + + E + + D +S K
Sbjct: 1206 ELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKT 1265
Query: 1496 RKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKD-------------TTSFEDISPQGV 1542
++E + + + +++ +G S+QL + KD T E++ Q
Sbjct: 1266 KEEEQQRLINELSAQKARLHTESGEFSRQL-DEKDAMVSQLSRGKQAFTQQIEELKRQLE 1324
Query: 1543 SDDSSTGSRVHASRPASLD 1561
+ + + HA + A D
Sbjct: 1325 EETKAKSTLAHALQSARHD 1343
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 177 bits (448), Expect = 1e-43
Identities = 279/1320 (21%), Positives = 550/1320 (41%), Gaps = 175/1320 (13%)
Query: 161 QEVTHNQENVF----DLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERD-----EHSETI 211
Q+ Q+ VF + +W + + +++ E L + + L +E + E E
Sbjct: 228 QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287
Query: 212 IELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKT 271
E EE L + ++ E R+ + + ++LR+E EE+
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347
Query: 272 EQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSR 331
EQ L +QE E+ E +L+R Q+E R + R E RE+ +R + R
Sbjct: 348 EQQLRREQEEERREQQLRREQEEE-------RREQQLRREQQLRREQQLR----REQQLR 396
Query: 332 YKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQL--EGTRARSDKLHELEKENLQLKA 389
+++L R ++L+ + Q+ E + E QL E R ++ HE E+ +LK
Sbjct: 397 REQQLR-------REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK- 448
Query: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKS 449
+ E RD +++ E E + K+ +E W + E E ++
Sbjct: 449 --REQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQ 506
Query: 450 LGHEVNELTSSRLLKLEME---------NQSLTKTVEELRTTVDSVEGNASKILKMEKEN 500
L E E RL + E E Q L + EE R + ++ K L+ E+
Sbjct: 507 LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL--LKREEEKRLEQERRE 564
Query: 501 QRLSKKVEILENEIV--QEKQSLQNCQNLSKDLMKEKAQLEKTIETL--RENSERQIKIL 556
QRL ++ E ++++ +E++ Q + ++ ++++ + E+ +E L E E+++K
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE-VERLEQEERREQRLKRE 623
Query: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIE-KENKILHESIKETSSKLSKIEFEKRQIKK 615
E E E Q + S Q + + R + E +E ++ E +E + K E E+ + ++
Sbjct: 624 EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ 683
Query: 616 ELEHYKEKGERAEELENEL----HHLEKENELLQKKI-------TNLKITCEKIEALEQE 664
EL +E+ + E +++ + LE E + Q K+ + E+ E +
Sbjct: 684 ELAE-EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742
Query: 665 NSEL--ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
SEL + E R ++ + + F + +E S+ + L R + + ++ +
Sbjct: 743 ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802
Query: 723 LQLENKEL---ESEKEQLK-------KGLELLKAS-----FKKTERLEVSYQGLDIENQR 767
Q + E EKEQ + K L+ L+ ++ ++L+ GL + +R
Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862
Query: 768 LQKTLENSNKKIQ-QLESE--------------LQDLEMENQTLQKNLEELKISSK-RLE 811
+ + ++K + QLE E + L E Q LQ+ EEL+ + +
Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRR 922
Query: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE---IKDTTLEENNVKIGNLEKENKT 868
+ E+E + E+E Q E+++ E+ KR RQ+ E KD L++ ++ E E +
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982
Query: 869 LSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
+ Y+E +EL++E ++L LRE+ EK + Q+ E+
Sbjct: 983 RQEREKKYREE----EELQQEEEQL-------------LREE--REKRRRQEW----ERQ 1019
Query: 929 THELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLE--IKEEKIAALEARLEES 986
+ +++ +E+LL +E+ + + + + E L++ E + EE+ LE
Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQ 1079
Query: 987 TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKD 1046
++L+QE + + + ++RQ+ ER + + E+ + RE +E K
Sbjct: 1080 YRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE--------KR 1131
Query: 1047 RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK 1106
R E+ER + E Q + QL + E + Q + + QE+ L+ + K
Sbjct: 1132 RRQELERQYRE-EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK 1190
Query: 1107 LQVENSTLNSQSTSLMNQNAQLLI----QQSSL----ENENESVI---------KEREDL 1149
+ E + L Q + Q+S L E E E+ + +E E
Sbjct: 1191 RRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQF 1250
Query: 1150 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK 1209
+ L DS ++D + + + + L+ + + + RD + L+++
Sbjct: 1251 RQLEDSQLRDRQSQQ--------DLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLERE 1302
Query: 1210 GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEV-----L 1264
Q E + K ++EK LL + E K+ E DR QLL+E E
Sbjct: 1303 EQKEAKRRDRKSQEEKQLLREEREE------KRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 1265 QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQC-ELLSQLKGNLEEE 1323
+ D K + L + + + LE E +L+ Q ++ + +C E QL+ ++
Sbjct: 1357 ERDRKFREEELRHQEQGRKFLEEE-QRLRRQERERKFLKEEQQLRCQEREQQLR---QDR 1412
Query: 1324 NRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKL---EEKIMDQ 1380
+R ++ Q L Q R + E + +R+++++ +LR+++ + EE+++ +
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472
Score = 168 bits (425), Expect = 5e-41
Identities = 249/1252 (19%), Positives = 522/1252 (41%), Gaps = 152/1252 (12%)
Query: 238 PGMKRTESRQHLSVELADAKAK------------------IRRLRQELEEKTE------Q 273
PG +R + RQ ELA+ + + + R RQE +E+ E Q
Sbjct: 133 PGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQ 192
Query: 274 LLDCK----------QELEQMEI-ELKRLQQENMNLLSDARSARMYRDELD---ALREKA 319
L CK ++L + E+ EL+R +E R R++++E + RE
Sbjct: 193 LQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV 252
Query: 320 VR--VDKLESEVSRYKERLHDIE--FYKARVEELKEDNQVLLETKTMLEDQLEGTRARSD 375
+R +KL+ E + + L + E K +EL+ + Q + + L + + R + +
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE 312
Query: 376 KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE- 434
+ E ++E + + + E R+ ++ +E E +++ ++ L E E
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372
Query: 435 ---QISRTSELSEAPQKSLGHEV---NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
Q+ R +L Q ++ +L + L+ E + + + E + + E
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Query: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
+ + E+ QRL ++ E + + +E+++ ++ Q + K QL++ E E
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE------RRKQQLKRDQE--EER 484
Query: 549 SERQIKILEQE-NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
ER +K+ E+E E + LR+ + E R+K E+E ++ E + + E
Sbjct: 485 RERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE 544
Query: 608 FEKRQIKKELEHYKEKGERAEELENELHH-----LEKENELLQKKI-------TNLKITC 655
++ +K+E E E+ R + L+ E L++E E Q+++ ++
Sbjct: 545 RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR 604
Query: 656 EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKE---NSQLDEENLE-----LR 707
E++E LEQE ER ++LK+ + L+S E+E QL E E L+
Sbjct: 605 EEVERLEQE----ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE-RLEVSYQGLDIE-- 764
R E + + + E +E E +E+ ++ E +K+ K + +LE +
Sbjct: 661 REEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY 720
Query: 765 ----NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK-----------ISSKR 809
Q Q+ + +K ++ ESELQ E E Q+ EE + S +
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 810 LEQLEKENKSLEQETSQLEKDKKQL----------EKENKRLRQQAEIKDTTLEENNVKI 859
++L EQ QL +++Q EKE +R +++ K+ E ++
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL 840
Query: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKEN-------KELVKRATIDIKTLVTLREDLV 912
E+ + +E G+ ++ R + ++ + +E KR + L+E L
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 913 SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIK 972
E+ Q+ +L++ E ++ +ER +E+ +LL + E ++ E +
Sbjct: 901 KEQQLLQEEEEELQREERE-KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959
Query: 973 EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1032
K L+ + E+ + R+ + KK E + +Q+EE++++ +WER
Sbjct: 960 YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE-KRRRQEWER 1018
Query: 1033 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1092
+ ++ EL + +++L+ ER LQ E++ + ++L+ + + Q+L +R+T
Sbjct: 1019 QYRKKD-ELQQEEEQLLREEREKRRLQ-ERERQYREEEELQQE----EEQLLGEERETRR 1072
Query: 1093 LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI-QQSSLENENESVIKEREDLKS 1151
QE + + Q E L + Q + ++ L+ E E +++E + +
Sbjct: 1073 RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR 1132
Query: 1152 LYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR---DLEDRYNQLLKQ 1208
+ + + E + + E + + K + LE ++R +L+ QLL++
Sbjct: 1133 ------RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLRE 1186
Query: 1209 KGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDH 1268
+ + E+ + +E+ L K K+ + D+ + Q E E D+
Sbjct: 1187 EQEKRRQERERQYREEEELQRQKR--------KQRYRDEDQRSDLKWQWEPEKENAVRDN 1238
Query: 1269 KNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL 1328
K N + Q E S+L+++ Q D+ Q Q + ++ +RH
Sbjct: 1239 KVYCKGRENEQFRQ----LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFP 1294
Query: 1329 DQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380
++ Q + + ++ +S+ E++Q + + E +R++++ + K ++
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQ-----EEKQLLREEREEKRRRQETDRKFREE 1341
Score = 159 bits (403), Expect = 2e-38
Identities = 296/1465 (20%), Positives = 587/1465 (40%), Gaps = 251/1465 (17%)
Query: 161 QEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDG 220
Q++ +QE +W++ + +E+ + L+R E++E E ++ EE +
Sbjct: 474 QQLKRDQEEERRERWLK---LEEEERREQQERREQQLRR---EQEERREQRLKRQEEEER 527
Query: 221 LHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQE 280
L S Q +R + + + + + + +RL++E EE+ +QLL K+E
Sbjct: 528 LQ---QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL--KRE 582
Query: 281 LEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKL---ESEVSRYKERLH 337
E+ + LKR Q+E + R+ R+E++ L ++ R +L E E R ++ L
Sbjct: 583 EERRQQRLKREQEERLE-------QRLKREEVERLEQEERREQRLKREEPEEERRQQLLK 635
Query: 338 DIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEME 397
E + R ++L+ + Q E + E++ E R + HE E+ +L + + E
Sbjct: 636 SEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARE 695
Query: 398 R----------------------------------------DMDRKKIEELM--EENMTL 415
R + R++ EL EE
Sbjct: 696 RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAH 755
Query: 416 EMAQKQSMDESLHLGWELEQ--------ISRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
Q++ W+ E+ +S L E ++ L E + R L E
Sbjct: 756 RQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEE 815
Query: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
E + + E + +E ++ + E+ Q ++ + E++ + Q + Q
Sbjct: 816 EKEQRRRQRREREKELQFLE-EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874
Query: 528 SKDLMKEKAQLEKTI---ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
L +E+ + T+ L+E ++ ++L++E E L + R+R + + R ++
Sbjct: 875 RWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE 934
Query: 585 I--EKENKILHES------------------IKETSSKLSKIEFEKRQIKKELEHYKEKG 624
++E ++L E +++ +L E EKR+ ++ + Y+E+
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE 994
Query: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN 684
E +E E +L E+E Q+ + K + L+QE +L RE R+ K+ L +
Sbjct: 995 ELQQE-EEQLLREEREKRRRQEWERQYR----KKDELQQEEEQLLREERE-KRRLQERER 1048
Query: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744
+ E L++E QL E E RR E L+ K +LQ E ++L E+ + ++ E
Sbjct: 1049 QYREEEELQQEEEQLLGEERETRRRQE-LERQYRKEEELQQEEEQLLREEPEKRRRQERE 1107
Query: 745 KASFKKTERLEVSYQGLDIENQ-RLQKTLENS---NKKIQQLESEL----------QDLE 790
+ ++ E + Q L E + R ++ LE +++QQ E +L Q+LE
Sbjct: 1108 RQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167
Query: 791 M---ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR--LRQQA 845
E + LQ+ E+L + + E+E + E+E Q +K K++ E++R L+ Q
Sbjct: 1168 RQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQW 1227
Query: 846 E-IKDTTLEENNVKIGNLEKE---------------NKTLSKEIGIYKE----------- 878
E K+ + +N V E E + L +G +E
Sbjct: 1228 EPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQ 1287
Query: 879 ----SCVRLKELEKENKELVK---RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931
++LE+E ++ K R + + K L+ + + +T + + E+L E
Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347
Query: 932 LEKIGLNK---------ERLLHDEQSTD-------------------------------- 950
E+ L + E L H EQ
Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407
Query: 951 -----DSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYE 1005
D +++ E +L + +EE+ + R + QQLRQE + E
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467
Query: 1006 ALKQRQDEERM---------VQSSPPISGED-----NKWERESQETTRELLKVKDRLIEV 1051
L Q ++E+++ ++ + ++ + E SQE R+ L+ + +L
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527
Query: 1052 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1111
+R LQ E+Q + + Q Q+ + + + RQ +EQ + Q ++ K ++E
Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ--EREEQQLSRQERDRKFRLEE 1585
Query: 1112 STL--NSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER 1169
+ Q M QL Q+ + E K RED + L+++ E+ +L +
Sbjct: 1586 QKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRED-----EQLLQEREEQQLHRQE 1640
Query: 1170 QASEYESLISKHGTLKSAHKNLEVEH-RDLEDRYNQLLKQKGQLEDL-----EKMLKVEQ 1223
+ ++ + + L+ + ++ H RD + R + L Q+G+ + L ++ + E+
Sbjct: 1641 RDRKF---LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE 1697
Query: 1224 EKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ-TDHKNLKSLLNNSKLEQ 1282
+++ + + + + E + E +R QL +ETE Q + + +L EQ
Sbjct: 1698 QQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEE---EQ 1754
Query: 1283 TRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLM-LQNRTL 1341
R E E +L+ Q + + Q QL+ +E +R ++ Q + + L
Sbjct: 1755 LRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS--QESDRKFREEEQLRQEREEQQL 1812
Query: 1342 LEQNMESKDLFHVEQRQYIDKLNELRRQKE---KLEEKIMDQYK--------FYDPSPPR 1390
Q + K + EQ Q ++ LR++++ + EE+ Q K + + R
Sbjct: 1813 RPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKR 1872
Query: 1391 RRGNWITLKMRKLIKSKKDINRERQ 1415
R+ L+ + + +K+ R RQ
Sbjct: 1873 RQERERKLREEHIRRQQKEEQRHRQ 1897
Score = 144 bits (362), Expect = 1e-33
Identities = 240/1168 (20%), Positives = 495/1168 (42%), Gaps = 139/1168 (11%)
Query: 202 DERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTES----RQHLSVELADAK 257
+E+ + E +L EE DGL S + + E R+H +
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ 896
Query: 258 AKIRRLRQELEEKTEQLLD------CKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
++R+ +Q L+E+ E+L +QE E+ E ++LQQE LL + R R ++
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE- 955
Query: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEE----LKEDNQVLLETKTMLEDQL 367
RE+ R DK ++ + +E+L E K R +E +E+ ++ E + +L ++
Sbjct: 956 ----RERQYRKDK---KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008
Query: 368 EGTRARS-----DKLHELEKENLQLKAKLHDME--MERDMDRKKIEELMEENMTL----- 415
E R + K EL++E QL + + ER+ ++ EEL +E L
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068
Query: 416 EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475
E ++Q ++ EL+Q L E P+K E E +L+ E + L +
Sbjct: 1069 ETRRRQELERQYRKEEELQQ-EEEQLLREEPEKRRRQE-RERQCREEEELQQEEEQLLRE 1126
Query: 476 VEELRTTVDSVEGNASKILKMEKENQ-RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE 534
E R + E E Q R ++V+ E ++++E+ + Q L + +E
Sbjct: 1127 EREKRR-------------RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Query: 535 KAQLEKTIETLRENSERQIKILEQ---ENEHLNQTVSSLRQRSQISAEARVK---DIEKE 588
+ ++ + LRE E++ + E+ E E L + R R + + +K + EKE
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE-DQRSDLKWQWEPEKE 1232
Query: 589 NKILHESI------KETSSKLSKIEFEKRQIKKELEHYK-EKGERAEELENEL-----HH 636
N + + E +L + RQ +++L+H E+ ER E E H
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292
Query: 637 LEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696
+E +L +++ K K + +Q E E R+ ++T F+ L+ E++
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Query: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEV 756
+ E + + R + K + + + E E++ LK+ +L + ER +
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL-----RCQEREQQ 1407
Query: 757 SYQGLD--IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLE 814
Q D + Q + + ++K ++ E +++ E E + L+ EE ++ +R +
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE---EEQQLRQERHRKFR 1464
Query: 815 KENKSL----EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870
+E + L EQ+ + E+D+K LE+E + RQ+ +D E ++ + E E K L
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE---RDRKFREQELR--SQEPERKFLE 1519
Query: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
+E ++++ R ++ +E ++L ++ + R+ E+L+ ++ L +
Sbjct: 1520 EEQQLHRQQ--RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577
Query: 931 ELEKIGLNKERLLHDEQST----DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 986
+ K L ++++ EQ D+ + + E + + ++ + +E++ L+ R E+
Sbjct: 1578 D-RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE-QLLQEREEQQ 1635
Query: 987 TNYNQ----------QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQE 1036
+ + QLR++ + + ++ ++ ++EE+++Q GE+ + R QE
Sbjct: 1636 LHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ-----EGEEQQLRR--QE 1688
Query: 1037 TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL-----QAQILALQRQTV 1091
R+ + + +L ER LQ E+Q + +L++ + L Q Q+ +R
Sbjct: 1689 RDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRK 1748
Query: 1092 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1151
L+E+ + + +L+ + + + Q + +Q E++ +E E L+
Sbjct: 1749 ILEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE---EQQLRSQESDRKFREEEQLR- 1804
Query: 1152 LYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ 1211
++ E+ +L +++ +Y + LE + + L ++ + + Q
Sbjct: 1805 ------QEREEQQLRPQQRDGKYR--------WEEEQLQLEEQEQRLRQERDRQYRAEEQ 1850
Query: 1212 LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET-EVLQTDHKN 1270
EK + EQE L + + + +KL E+ R Q ++ E+ + K
Sbjct: 1851 FATQEKSRREEQE--LWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKG 1908
Query: 1271 LKSLLNNSKLEQTRLEAEFSKLKEQYQQ 1298
LL + + S L E Q+
Sbjct: 1909 HGRLLEPGTHQFASVPVRSSPLYEYIQE 1936
Score = 79.0 bits (193), Expect = 4e-14
Identities = 140/640 (21%), Positives = 264/640 (41%), Gaps = 83/640 (12%)
Query: 773 ENSNKKIQQLESELQDLEMEN-----QTLQKNLEELKISSKRLEQLEKENKSLEQETSQ- 826
E + ES LQD E + + LEE +R ++ E+E + E E
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 827 -----LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCV 881
++D+++ ++E R RQ+ + ++ E E + E + + +
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216
Query: 882 RLKELEKENKELVKRATID-----------IKTLVTLR---EDLVSEKLKTQQMNNDLEK 927
L+ +E K+ +R D K LR E L E+ + Q+ + E+
Sbjct: 217 ELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEE 276
Query: 928 LTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEEST 987
+LE+ L +ER ++Q R + L K E ++ E +EE+ E R ++
Sbjct: 277 QLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE---EERREQQEERREQQERREQQEE 333
Query: 988 NYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDR 1047
QQLR+E + ++ + L++ Q+EER Q + E + RE Q + L+ + +
Sbjct: 334 RREQQLRREQE--ERREQQLRREQEEERREQQ---LRREQEEERREQQLRREQQLRREQQ 388
Query: 1048 LIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKL 1107
L R L+ E+Q + Q + E Q Q L+R+ +EQ Q +
Sbjct: 389 L----RREQQLRREQQLRREQQLRREQQLRREQ----QLRREQQLRREQEEERHEQKHEQ 440
Query: 1108 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK----- 1162
+ L + ++ L+ E E+ ER + + L +D E+
Sbjct: 441 ERREQRLKREQEE----------RRDWLKREEET---ERHEQERRKQQLKRDQEEERRER 487
Query: 1163 -LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-----EDLE 1216
L+L E + + E + + + ++ ++ E+R Q L+ + QL E E
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547
Query: 1217 KMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLN 1276
++LK E+EK L + + + + E ++ QLLK E + + LK
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEE----------RRDQLLKREE--ERRQQRLKR-EQ 594
Query: 1277 NSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLML 1336
+LEQ RL+ E + EQ ++ + + + E QL + E+E R + Q L
Sbjct: 595 EERLEQ-RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER----RQQQLRR 649
Query: 1337 QNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
+ + EQ ++ ++ +++ + E RR++E EE+
Sbjct: 650 EQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE 689
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 176 bits (447), Expect = 1e-43
Identities = 254/1134 (22%), Positives = 456/1134 (40%), Gaps = 139/1134 (12%)
Query: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE-QMEIELKRLQ--QENMNLLS 300
E Q + ELA ++AK R+ELEEK LL K +L+ Q++ E + L +E + L
Sbjct: 860 EEFQKIKDELAKSEAK----RKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLI 915
Query: 301 DARS---------ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE 351
+ DE + E + KLE E S K+ + D+E A+VE+ K
Sbjct: 916 KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 975
Query: 352 DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQL--KAKLHDMEMERDMDRKKIEELM 409
+ ++ T L+ T A+ K EK+ LQ + L D++ E D K+ L
Sbjct: 976 ATENKVKNLTEEMAGLDETIAKLTK----EKKALQEAHQQTLDDLQAEED----KVNTLT 1027
Query: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
+ + LE Q +D+ L LEQ + E ++ L ++ +L ++ +E E
Sbjct: 1028 KAKIKLE----QQVDD---LEGSLEQEKKLRMDLERAKRKLEGDL-KLAQESIMDIENEK 1079
Query: 470 QSLTKTVE----ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ 525
Q L + ++ E+ +E + ++++K+ + L ++E LE EI E+ S +
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE 1139
Query: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585
DL +E ++ + +E + QI++ ++ + L + + + EA +
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT-LQHEATAATL 1198
Query: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQ 645
K++ +S+ E ++ ++ K++++KE E++ E+ L E +
Sbjct: 1199 RKKHA---DSVAELGEQIDNLQRVKQKLEKE----------KSEMKMEIDDLASNVETVS 1245
Query: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705
K NL+ C +E E E E ++L +LT Q L+ E+ + + E
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRL------INDLTAQRGRLQTESGEFSRQLDE 1299
Query: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL-ELLKASFKKTERLEVSYQGLDIE 764
V L Q E K E+ + K L L++S + L Y+
Sbjct: 1300 KEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQES 1359
Query: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET 824
LQ+ L +N ++ Q ++ E +Q+ EEL+ + K+L Q ++ E+
Sbjct: 1360 KAELQRALSKANTEVAQWRTKY-----ETDAIQRT-EELEEAKKKLAQ---RLQAAEEHV 1410
Query: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
+ LEK +RL+ + E +E N L+K+ + K + +K+ C
Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1470
Query: 885 -ELEKENKELVKRATIDIKTLVTLREDLVS-EKLKTQQMNNDLE------------KLTH 930
ELE KE T K E L E LK + N E K H
Sbjct: 1471 AELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH 1530
Query: 931 ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN 990
ELEKI E+ + Q+ + LE + L+ LE+ + K E+ +
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590
Query: 991 QQLRQELKTVKKNYEAL----KQRQDEERMVQSSPPISGEDNKWERE------------- 1033
Q R ++ V+ L + R D R+ + + G+ N+ E +
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK---MEGDLNEMEIQLNHANRMAAEALR 1647
Query: 1034 SQETTRELLK---------------VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN 1078
+ T+ +LK +K++L VER LQAE + L+ L+Q E
Sbjct: 1648 NYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKI 1707
Query: 1079 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1138
+ ++L + L QNT+L KL+ + S + + ++ + N
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQE----------ARNA 1757
Query: 1139 NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL-EVEHRD 1197
E K D + + L K+ + L ER E T+K L E E
Sbjct: 1758 EEKAKKAITDAAMMAEELKKEQDTSAHL-ERMKKNMEQ------TVKDLQLRLDEAEQLA 1810
Query: 1198 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1257
L+ Q+ K + ++ +LE ++ EQ++ K K+L + + +L
Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRL 1870
Query: 1258 LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK----LKEQYQQLDITSTKLN 1307
+ LQ K+ K ++ + A+F K L+E ++ DI +++N
Sbjct: 1871 QDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVN 1924
Score = 166 bits (419), Expect = 3e-40
Identities = 219/1050 (20%), Positives = 464/1050 (44%), Gaps = 147/1050 (14%)
Query: 149 DFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHS 208
D D A +++ H EN +V ++++E + L + +A K ++ H
Sbjct: 959 DIDDLELTLAKVEKEKHATEN-------KVKNLTEE-MAGLDETIAKLTKEKKALQEAHQ 1010
Query: 209 ETIIELSEERDGLHFLPHASSSAQSPCGS-PGMKRTESRQHLSVELADAKAKIRRLRQEL 267
+T+ +L E D ++ L A + G E + + +E A R+L +L
Sbjct: 1011 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAK-----RKLEGDL 1065
Query: 268 EEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-LREKAVRVDKLE 326
+ E ++D + E +Q++ +LK+ + E NL S + +L ++E R+++LE
Sbjct: 1066 KLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELE 1125
Query: 327 SEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ 386
E+ + +A+ E+ + D LE + ++LE + E+ K
Sbjct: 1126 EEIEAERAS-------RAKAEKQRSDLSRELEE---ISERLEEAGGATSAQIEMNK---- 1171
Query: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
K + +M RD++ E ++ T +K+ D LG +++ + R + E
Sbjct: 1172 -KREAEFQKMRRDLE----EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE 1226
Query: 447 QKSLGHEVNELTSS--RLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL--------KM 496
+ + E+++L S+ + K + + + +T+E+ + + S E +++ ++
Sbjct: 1227 KSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRL 1286
Query: 497 EKENQRLSKKV---EILENEIVQEKQSL-QNCQNLSKDL---MKEKAQLEKTIETLRENS 549
+ E+ S+++ E L +++ + KQ+ Q + L + L +K K L +++ R +
Sbjct: 1287 QTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDC 1346
Query: 550 ERQIKILEQENEH----------LNQTVSSLRQRSQISAEARVKDIEKENKIL------- 592
+ + E+E E N V+ R + + A R +++E+ K L
Sbjct: 1347 DLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA 1406
Query: 593 HESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK 652
E ++ ++K + +E K++++ E+E ER L+K+ K + K
Sbjct: 1407 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAA---CAALDKKQRNFDKILAEWK 1463
Query: 653 ITCEKIEA-LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
CE+ A LE E +L K ++++ QLE+L++EN L +E +L E
Sbjct: 1464 QKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL---TE 1520
Query: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE------RLEVSYQGLDIEN 765
+ ++ +L+ K++E EK +L+ LE +AS + E +LE++ +++
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580
Query: 766 QRLQKTLENSNKK---IQQLESELQDLEME----------NQTLQKNLEELKISSKRLEQ 812
+ +K E K I+ +ES L+ E + ++ +L E++I +
Sbjct: 1581 KIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1640
Query: 813 LEKENKSLEQETSQLEKD-----------KKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861
+ E + T + KD ++ L+++ + ++A + +EE +
Sbjct: 1641 MAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1700
Query: 862 LEKENKTLSKEIGIYKESCVRLKELEKENKELV---KRATIDIKTLVTLREDLVSE---- 914
E+ K +E+ ++ R++ L +N L+ K+ DI + ED++ E
Sbjct: 1701 TERSRKIAEQEL---LDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNA 1757
Query: 915 KLKTQQMNNDLEKLTHELEK---IGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI 971
+ K ++ D + EL+K + ER+ + + T K L+ +L+ + +L+
Sbjct: 1758 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT----VKDLQLRLDEAEQLALKG 1813
Query: 972 KEEKIAALEARLEESTNYNQQLRQELKTV-KKNYEALKQRQDEERMVQSSPPISGEDNKW 1030
+++I LEAR+ E L E+++ K+N EA+K + ER V+ + ED K
Sbjct: 1814 GKKQIQKLEARVRE-------LEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRK- 1865
Query: 1031 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1090
+L+++D + + LQA+ ++ K Q ++ E Q+N A+ LQ +
Sbjct: 1866 ---------NILRLQDLVDK-------LQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL 1909
Query: 1091 VSLQEQNTTLQTQNAKLQVENSTLNSQSTS 1120
+E+ ++Q KL+V++ ++++ S
Sbjct: 1910 EEAEERADIAESQVNKLRVKSREVHTKVIS 1939
Score = 108 bits (269), Expect = 6e-23
Identities = 163/797 (20%), Positives = 341/797 (42%), Gaps = 89/797 (11%)
Query: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ-QLE 783
L++ E E E +K+ + +K K+E + ++E + + E ++ ++Q Q E
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEA-----KRKELEEKMVTLLKEKNDLQLQVQAE 900
Query: 784 SE-LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
+E L D E L K +L+ K + + ++ + + E L K++LE E L+
Sbjct: 901 AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAE---LTAKKRKLEDECSELK 957
Query: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
+ + + TL + + E + K L++E+ E+ +L + +K +E ++ D++
Sbjct: 958 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1017
Query: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER----LLHDEQSTDDSRYKLLE 958
L K+K +Q +DLE + +K+ ++ ER L D + +S +
Sbjct: 1018 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077
Query: 959 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1018
K + L + L+ KE +I+ L++++E+ QL++++K ++ E L++ + ER +
Sbjct: 1078 EKQQ--LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135
Query: 1019 SSPPISGEDNKWERESQETTRELLKVKDRLIEVE-------RNNATLQAEKQALKTQLKQ 1071
+ K E++ + +REL ++ +RL E N +AE Q ++ L++
Sbjct: 1136 A---------KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186
Query: 1072 LETQNNNLQA--------QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN 1123
Q+ A + L Q +LQ L+ + +++++E L S ++
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSK 1246
Query: 1124 QNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL---LHERQASEYESLISK 1180
L +LE++ + + E+ + L + L +L+ RQ E E+L+S+
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ 1306
Query: 1181 HGTLKSAH-KNLEVEHRDLEDRY-------NQLLKQKGQLEDLEKMLKVEQE-----KML 1227
K A + +E R LE+ + L + + L + + EQE +
Sbjct: 1307 LSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRA 1366
Query: 1228 LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA 1287
L N E K R K + LQ ++++++ N+K LE
Sbjct: 1367 LSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAV--NAKC--ASLEK 1422
Query: 1288 EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE---------ENRHLLDQIQTLMLQN 1338
+L+ + + L + + N C L + + N ++ E H +++ +
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA--ELEASQKEA 1480
Query: 1339 RTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITL 1398
R+L + + K+ + + +D+L L+R+ + L+++I D + R
Sbjct: 1481 RSLGTELFKIKNAY----EESLDQLETLKRENKNLQQEISDLTEQIAEGGKR-------- 1528
Query: 1399 KMRKLIKSKKDINRER---QKSLTLTPTRSDSSEG-FLQLPHQDSQDSSSVGSNSLEDGQ 1454
+ +L K KK + +E+ Q +L + EG L++ + +Q S V E +
Sbjct: 1529 -IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE 1587
Query: 1455 TLGTKKSSTMNDLVQSM 1471
+ K + + +V+SM
Sbjct: 1588 EIDQLKRNHIR-IVESM 1603
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 176 bits (447), Expect = 1e-43
Identities = 254/1134 (22%), Positives = 456/1134 (40%), Gaps = 139/1134 (12%)
Query: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE-QMEIELKRLQ--QENMNLLS 300
E Q + ELA ++AK R+ELEEK LL K +L+ Q++ E + L +E + L
Sbjct: 860 EEFQKIKDELAKSEAK----RKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLI 915
Query: 301 DARS---------ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE 351
+ DE + E + KLE E S K+ + D+E A+VE+ K
Sbjct: 916 KTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 975
Query: 352 DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQL--KAKLHDMEMERDMDRKKIEELM 409
+ ++ T L+ T A+ K EK+ LQ + L D++ E D K+ L
Sbjct: 976 ATENKVKNLTEEMAGLDETIAKLTK----EKKALQEAHQQTLDDLQAEED----KVNTLT 1027
Query: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
+ + LE Q +D+ L LEQ + E ++ L ++ +L ++ +E E
Sbjct: 1028 KAKIKLE----QQVDD---LEGSLEQEKKLRMDLERAKRKLEGDL-KLAQESIMDIENEK 1079
Query: 470 QSLTKTVE----ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ 525
Q L + ++ E+ +E + ++++K+ + L ++E LE EI E+ S +
Sbjct: 1080 QQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE 1139
Query: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585
DL +E ++ + +E + QI++ ++ + L + + + EA +
Sbjct: 1140 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT-LQHEATAATL 1198
Query: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQ 645
K++ +S+ E ++ ++ K++++KE E++ E+ L E +
Sbjct: 1199 RKKHA---DSVAELGEQIDNLQRVKQKLEKE----------KSEMKMEIDDLASNVETVS 1245
Query: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLE 705
K NL+ C +E E E E ++L +LT Q L+ E+ + + E
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRL------INDLTAQRGRLQTESGEFSRQLDE 1299
Query: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL-ELLKASFKKTERLEVSYQGLDIE 764
V L Q E K E+ + K L L++S + L Y+
Sbjct: 1300 KEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQES 1359
Query: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET 824
LQ+ L +N ++ Q ++ E +Q+ EEL+ + K+L Q ++ E+
Sbjct: 1360 KAELQRALSKANTEVAQWRTKY-----ETDAIQRT-EELEEAKKKLAQ---RLQAAEEHV 1410
Query: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
+ LEK +RL+ + E +E N L+K+ + K + +K+ C
Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETH 1470
Query: 885 -ELEKENKELVKRATIDIKTLVTLREDLVS-EKLKTQQMNNDLE------------KLTH 930
ELE KE T K E L E LK + N E K H
Sbjct: 1471 AELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIH 1530
Query: 931 ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN 990
ELEKI E+ + Q+ + LE + L+ LE+ + K E+ +
Sbjct: 1531 ELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1590
Query: 991 QQLRQELKTVKKNYEAL----KQRQDEERMVQSSPPISGEDNKWERE------------- 1033
Q R ++ V+ L + R D R+ + + G+ N+ E +
Sbjct: 1591 QLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK---MEGDLNEMEIQLNHANRMAAEALR 1647
Query: 1034 SQETTRELLK---------------VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN 1078
+ T+ +LK +K++L VER LQAE + L+ L+Q E
Sbjct: 1648 NYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKI 1707
Query: 1079 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1138
+ ++L + L QNT+L KL+ + S + + ++ + N
Sbjct: 1708 AEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQE----------ARNA 1757
Query: 1139 NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL-EVEHRD 1197
E K D + + L K+ + L ER E T+K L E E
Sbjct: 1758 EEKAKKAITDAAMMAEELKKEQDTSAHL-ERMKKNMEQ------TVKDLQLRLDEAEQLA 1810
Query: 1198 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1257
L+ Q+ K + ++ +LE ++ EQ++ K K+L + + +L
Sbjct: 1811 LKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRL 1870
Query: 1258 LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK----LKEQYQQLDITSTKLN 1307
+ LQ K+ K ++ + A+F K L+E ++ DI +++N
Sbjct: 1871 QDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVN 1924
Score = 166 bits (419), Expect = 3e-40
Identities = 219/1050 (20%), Positives = 464/1050 (44%), Gaps = 147/1050 (14%)
Query: 149 DFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHS 208
D D A +++ H EN +V ++++E + L + +A K ++ H
Sbjct: 959 DIDDLELTLAKVEKEKHATEN-------KVKNLTEE-MAGLDETIAKLTKEKKALQEAHQ 1010
Query: 209 ETIIELSEERDGLHFLPHASSSAQSPCGS-PGMKRTESRQHLSVELADAKAKIRRLRQEL 267
+T+ +L E D ++ L A + G E + + +E A R+L +L
Sbjct: 1011 QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAK-----RKLEGDL 1065
Query: 268 EEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-LREKAVRVDKLE 326
+ E ++D + E +Q++ +LK+ + E NL S + +L ++E R+++LE
Sbjct: 1066 KLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELE 1125
Query: 327 SEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ 386
E+ + +A+ E+ + D LE + ++LE + E+ K
Sbjct: 1126 EEIEAERAS-------RAKAEKQRSDLSRELEE---ISERLEEAGGATSAQIEMNK---- 1171
Query: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
K + +M RD++ E ++ T +K+ D LG +++ + R + E
Sbjct: 1172 -KREAEFQKMRRDLE----EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKE 1226
Query: 447 QKSLGHEVNELTSS--RLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL--------KM 496
+ + E+++L S+ + K + + + +T+E+ + + S E +++ ++
Sbjct: 1227 KSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRL 1286
Query: 497 EKENQRLSKKV---EILENEIVQEKQSL-QNCQNLSKDL---MKEKAQLEKTIETLRENS 549
+ E+ S+++ E L +++ + KQ+ Q + L + L +K K L +++ R +
Sbjct: 1287 QTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDC 1346
Query: 550 ERQIKILEQENEH----------LNQTVSSLRQRSQISAEARVKDIEKENKIL------- 592
+ + E+E E N V+ R + + A R +++E+ K L
Sbjct: 1347 DLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAA 1406
Query: 593 HESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLK 652
E ++ ++K + +E K++++ E+E ER L+K+ K + K
Sbjct: 1407 EEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAA---CAALDKKQRNFDKILAEWK 1463
Query: 653 ITCEKIEA-LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
CE+ A LE E +L K ++++ QLE+L++EN L +E +L E
Sbjct: 1464 QKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDL---TE 1520
Query: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE------RLEVSYQGLDIEN 765
+ ++ +L+ K++E EK +L+ LE +AS + E +LE++ +++
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDR 1580
Query: 766 QRLQKTLENSNKK---IQQLESELQDLEME----------NQTLQKNLEELKISSKRLEQ 812
+ +K E K I+ +ES L+ E + ++ +L E++I +
Sbjct: 1581 KIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANR 1640
Query: 813 LEKENKSLEQETSQLEKD-----------KKQLEKENKRLRQQAEIKDTTLEENNVKIGN 861
+ E + T + KD ++ L+++ + ++A + +EE +
Sbjct: 1641 MAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQ 1700
Query: 862 LEKENKTLSKEIGIYKESCVRLKELEKENKELV---KRATIDIKTLVTLREDLVSE---- 914
E+ K +E+ ++ R++ L +N L+ K+ DI + ED++ E
Sbjct: 1701 TERSRKIAEQEL---LDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNA 1757
Query: 915 KLKTQQMNNDLEKLTHELEK---IGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEI 971
+ K ++ D + EL+K + ER+ + + T K L+ +L+ + +L+
Sbjct: 1758 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT----VKDLQLRLDEAEQLALKG 1813
Query: 972 KEEKIAALEARLEESTNYNQQLRQELKTV-KKNYEALKQRQDEERMVQSSPPISGEDNKW 1030
+++I LEAR+ E L E+++ K+N EA+K + ER V+ + ED K
Sbjct: 1814 GKKQIQKLEARVRE-------LEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRK- 1865
Query: 1031 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1090
+L+++D + + LQA+ ++ K Q ++ E Q+N A+ LQ +
Sbjct: 1866 ---------NILRLQDLVDK-------LQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHEL 1909
Query: 1091 VSLQEQNTTLQTQNAKLQVENSTLNSQSTS 1120
+E+ ++Q KL+V++ ++++ S
Sbjct: 1910 EEAEERADIAESQVNKLRVKSREVHTKVIS 1939
Score = 108 bits (269), Expect = 6e-23
Identities = 163/797 (20%), Positives = 341/797 (42%), Gaps = 89/797 (11%)
Query: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ-QLE 783
L++ E E E +K+ + +K K+E + ++E + + E ++ ++Q Q E
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKSEA-----KRKELEEKMVTLLKEKNDLQLQVQAE 900
Query: 784 SE-LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
+E L D E L K +L+ K + + ++ + + E L K++LE E L+
Sbjct: 901 AEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAE---LTAKKRKLEDECSELK 957
Query: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
+ + + TL + + E + K L++E+ E+ +L + +K +E ++ D++
Sbjct: 958 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ 1017
Query: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER----LLHDEQSTDDSRYKLLE 958
L K+K +Q +DLE + +K+ ++ ER L D + +S +
Sbjct: 1018 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN 1077
Query: 959 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1018
K + L + L+ KE +I+ L++++E+ QL++++K ++ E L++ + ER +
Sbjct: 1078 EKQQ--LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135
Query: 1019 SSPPISGEDNKWERESQETTRELLKVKDRLIEVE-------RNNATLQAEKQALKTQLKQ 1071
+ K E++ + +REL ++ +RL E N +AE Q ++ L++
Sbjct: 1136 A---------KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186
Query: 1072 LETQNNNLQA--------QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN 1123
Q+ A + L Q +LQ L+ + +++++E L S ++
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSK 1246
Query: 1124 QNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL---LHERQASEYESLISK 1180
L +LE++ + + E+ + L + L +L+ RQ E E+L+S+
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ 1306
Query: 1181 HGTLKSAH-KNLEVEHRDLEDRY-------NQLLKQKGQLEDLEKMLKVEQE-----KML 1227
K A + +E R LE+ + L + + L + + EQE +
Sbjct: 1307 LSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRA 1366
Query: 1228 LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA 1287
L N E K R K + LQ ++++++ N+K LE
Sbjct: 1367 LSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAV--NAKC--ASLEK 1422
Query: 1288 EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE---------ENRHLLDQIQTLMLQN 1338
+L+ + + L + + N C L + + N ++ E H +++ +
Sbjct: 1423 TKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHA--ELEASQKEA 1480
Query: 1339 RTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITL 1398
R+L + + K+ + + +D+L L+R+ + L+++I D + R
Sbjct: 1481 RSLGTELFKIKNAY----EESLDQLETLKRENKNLQQEISDLTEQIAEGGKR-------- 1528
Query: 1399 KMRKLIKSKKDINRER---QKSLTLTPTRSDSSEG-FLQLPHQDSQDSSSVGSNSLEDGQ 1454
+ +L K KK + +E+ Q +L + EG L++ + +Q S V E +
Sbjct: 1529 -IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDE 1587
Query: 1455 TLGTKKSSTMNDLVQSM 1471
+ K + + +V+SM
Sbjct: 1588 EIDQLKRNHIR-IVESM 1603
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 176 bits (446), Expect = 2e-43
Identities = 270/1296 (20%), Positives = 536/1296 (41%), Gaps = 115/1296 (8%)
Query: 115 EQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQ 174
+Q EE ++L + Q Q E + + + K +EV +E D Q
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1412
Query: 175 WMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSP 234
+ + QE+++ L ++ ++ + + + + + EE + A+ +
Sbjct: 1413 QQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG- 1469
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294
G+ G Q L +A+A+ R+ ++E E Q+ D Q Q E+EL
Sbjct: 1470 -GAEG-----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---- 1519
Query: 295 NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
+ ++A +AR + L AL E ++ ++ E RL E +AR Q
Sbjct: 1520 --RVKAEAEAAREKQRALQALEELRLQAEEAE-------RRLRQAEVERAR------QVQ 1564
Query: 355 VLLET-KTMLEDQLEGTRAR-SDKLHELEK---ENLQLKAKLHDMEMERDMDRKKIEELM 409
V LET + E +L+ RA ++K +LE+ E A+L + R + + E
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 410 EE-NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
EE LE Q ++ +E+L L + E++++ L++A + E R E
Sbjct: 1625 EEAERELERWQLKA-NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE-------ILENEIVQEKQ-- 519
+ +EL EG A + L E+E RL + E +LE E+ + ++
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 520 --SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
+ Q Q L +L K +A++E + + E E+ + L R+ ++ +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 578 AEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA---EELEN 632
A R ++ +++ ++ E ++ ++ EK E K + E A +E EN
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS-FKNLTFQLES 691
E E+E Q++ E Q +++E +L+K DS + +E
Sbjct: 1864 ERLRRLAEDEAFQRRRLE--------EQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
++ Q++EE L L+ + E A+ A+L+LE + S E + E + +
Sbjct: 1916 TLRQRRQVEEEILALKASFEK---AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 752 ERLEVSYQGLDIE-NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
+L + E +R+QK+L + +Q ++ L+++E L+ +EE + +R
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARRLRERA 2028
Query: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKR----LRQQAEIKDTTLEENNVKIGNLEKEN 866
EQ L QE +Q K+L+ E K ++Q+ + TL++ + L E
Sbjct: 2029 EQESARQLQLAQEAAQ-----KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
+ + +E+ V+ + +++ V+ A L++ + Q E
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSAEEQAQARAQAQAAAE 2136
Query: 927 KLTHELEKIGLNK---ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARL 983
KL E E+ + E+ ++ D+ + + E TL++ ++++E + L +L
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQL 2195
Query: 984 EESTNYNQQLRQELKTVKKNY-EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1042
EE+ + L +EL+ +K EA +QR E + S E +K + + R L+
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255
Query: 1043 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1102
L + + LQ E + +K + E ++ AQ A RQ L E++ Q
Sbjct: 2256 -----LRDKDNTQRFLQEEAEKMKQVAE--EAARLSVAAQEAARLRQ---LAEEDLAQQR 2305
Query: 1103 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1162
A+ ++ Q + + A+LL QQ L E ++E D + + L ++ +
Sbjct: 2306 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQG 2363
Query: 1163 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-EDLEKMLKV 1221
+ E + + ++ LK + E+ + KQ ++ E L +
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 1222 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1281
QEK+ L +T+ + ++ + +RL ++L +E E LQ + K L+ L + +++
Sbjct: 2424 TQEKVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQ 2477
Query: 1282 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL 1341
+ E + Q+ ++ + L Q + +E+E L Q + + + L
Sbjct: 2478 TVQQE-------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530
Query: 1342 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
E+ + E+++ + + E RR++ + EE +
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Score = 150 bits (379), Expect = 1e-35
Identities = 256/1233 (20%), Positives = 506/1233 (41%), Gaps = 146/1233 (11%)
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA-----RSAR 306
EL KA +++LR + E + + EL + +RLQQ + + R A+
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183
Query: 307 MYRDELDALREKAVRVDKLES---EVSRYKERLHDIEFY----KARVEELK----EDNQV 355
+ L + VR +LE ++ Y+E + + + R E+++ D+Q
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243
Query: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME--ENM 413
+ E + LE +K+ E ++ Q + D E++ + ++E + +
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303
Query: 414 TLEMAQKQSMDESLHLGWELEQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
++ + + E + L +++ TS+ + ++L E + + E E + L
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1362
Query: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
+ L E +A + E+E + L ++ ++ E+V+ +++ + Q + +
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR---MQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR------QRSQISAE------- 579
+E QL ++ E + RQ + E+ + + + +R +R + AE
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLE 638
AR ++ E + + E + ++ KRQ + EL K + E A E + L LE
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698
+ LQ + ++ ++E Q LE R + L S K +F ++ + E S
Sbjct: 1540 ELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS-KRASFAEKTAQLERS- 1595
Query: 699 LDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLK-KGLELLK--------ASFK 749
L EE++ + + E + + + A+ + +E E E E+ + K E L+ A K
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655
Query: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQ----TLQKNL---EE 802
+ E Q + E + ++ + + ++Q E Q+LE + Q T Q+ L +E
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 803 LKISSKRLEQLEKENKSLEQETSQLEKD-------KKQLEKENKRLRQQAEI----KDTT 851
L EQ E++ + LE+E ++L+++ +++LE E ++R + E+ K
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 852 LEENNVKIGNLEKENKTLSKEIGIYK---ESCVRLKELEKENKELVKRATIDIKTLVTLR 908
EE+ EK + L E G ++ E RL+ L +E K + A D
Sbjct: 1775 EEESR---STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 909 EDLVSEKL----KTQQMNNDLEKLTHELEKIGLNKERLLHDE------------------ 946
E +++EKL + ++ + E E E RL DE
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 947 -------QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
+ DS + + +E TL++ ++ EE+I AL+A E++ +L EL
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQV-EEEILALKASFEKAAAGKAELELELGR 1950
Query: 1000 VKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1058
++ N E L+ ++ E ++ E+ + RE++E ++ L ++ E R
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE---EAARQRKAA 2007
Query: 1059 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1118
E + LK +++ +A+ L + + S ++ + +LQ E ++ +
Sbjct: 2008 LEEVERLKAKVE---------EARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-HAFA 2057
Query: 1119 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1178
Q Q +QQ +SV+ + ++ E+ + ER+A++ +
Sbjct: 2058 VQQKEQELQQTLQQ------EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 1179 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1238
+ LK + + + +L K+ Q E + + E+ L K
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ----EAARRAQAEQAALRQKQAADAEM 2167
Query: 1239 E-YKKLCGENDRLNHTYSQLLK--ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1295
E +KK + R Q L ++ +TDH+ K+LL+ E RL+AE ++ Q
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ--KNLLDE---ELQRLKAEATEAARQ 2222
Query: 1296 YQQLDITSTKLNNQCELLSQLKGNLEEENRHLL----DQIQTLMLQNRTLLEQNMESKDL 1351
Q++ + Q E LS+LK +E ENR L+ D Q + + ++Q E
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 1352 FHVEQRQYIDKLNELRR----QKEKLEEKIMDQ 1380
V Q +L +L Q+ L EK++ +
Sbjct: 2283 LSV-AAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Score = 133 bits (334), Expect = 2e-30
Identities = 205/990 (20%), Positives = 418/990 (42%), Gaps = 146/990 (14%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
T+ ++ + L + +A + + E EL++ R + L + + A+ S
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781
Query: 239 GMK---RTESRQHLSVELADAKAKIRRLRQE----------------------LEEKTEQ 273
K R E+ ELA+ A++R L +E L EK
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 274 LLDCKQELEQMEIELKRLQQENMNL--LSDARSARMYRDELDALREKAVRVDKL------ 325
+ + + + EI LK + EN L L++ + + R E A + KA ++L
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 326 -ESEVSRYKERLHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARS-DKLHE 379
+SE+ R K + D + +VEE LK + K LE +L R+ + D L
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE----MAQKQSMDESLHLGWELEQ 435
E+ L+ A+ + E + R++ EE +++++ E +K +++E L ++E+
Sbjct: 1962 KEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020
Query: 436 ISRTSELSEAPQKSLGHEVNELTSSRL--------LKLEMENQSLTKTVEELRTTVDSVE 487
R E +E E RL ++ + Q L +T+++ ++ +D +
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE---KAQLEKTIET 544
G A + +E + + E E Q ++ ++ + L + ++ +AQ + E
Sbjct: 2081 GEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS--- 601
LR+ +E++ Q + ++LRQ+ AE +EK K +++++ +
Sbjct: 2138 LRKEAEQEAARRAQAEQ------AALRQKQAADAE-----MEKHKKFAEQTLRQKAQVEQ 2186
Query: 602 -------KLSKIEFEKRQIKKELEHYK----EKGERAEELENELHHLEKENELLQKKITN 650
+L + + +K + +EL+ K E + ++E EL + + E L K
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR 2246
Query: 651 LKITCEKIEALEQENSE--LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRR 708
++ + +++N++ L+ E K+K+ + L+ + + QL EE+L +R
Sbjct: 2247 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-QLAEEDLAQQR 2305
Query: 709 NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT-ERLEVSYQGLDIENQR 767
+ K KM +Q E L++E E L++ EL + ++ E E Q L E Q
Sbjct: 2306 ALAE-KMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 768 LQKTLENSNKKIQQLESELQDLEM--------------ENQTLQKNLEELKISSKRLEQL 813
Q+TLE ++ ++ +E + L++ + Q +K EE+ R E
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 814 EKENKSLEQ-----------ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE-NNVKIGN 861
+E +L Q + +L + +LE+E ++L+Q+A++ EE V+
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 862 LEKENKTLSKEIGIYKESCV-RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
L +E + L + K+S + R + +E+E +L + ++ LRE+ ++ + QQ
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE---QQRQQQQ 2540
Query: 921 MNNDLEKLT------------------------HELEKIGLNKERLLHDEQSTDDSRYKL 956
M + ++L +LE+ +E LL +E + +L
Sbjct: 2541 MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2600
Query: 957 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1016
LE + + L S E+ ++AA + L + E + + +++ L+++ +R+
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKT-LPNGRDALDGPAAEAEP-EHSFDGLRRKVSAQRL 2658
Query: 1017 VQSSPPISGEDNKWERESQETTRELLKVKD 1046
Q + +S E+ + + T EL + +D
Sbjct: 2659 -QEAGILSAEELQRLAQGHTTVDELARRED 2687
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 176 bits (446), Expect = 2e-43
Identities = 270/1296 (20%), Positives = 536/1296 (41%), Gaps = 115/1296 (8%)
Query: 115 EQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQ 174
+Q EE ++L + Q Q E + + + K +EV +E D Q
Sbjct: 1357 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1416
Query: 175 WMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSP 234
+ + QE+++ L ++ ++ + + + + + EE + A+ +
Sbjct: 1417 QQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG- 1473
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294
G+ G Q L +A+A+ R+ ++E E Q+ D Q Q E+EL
Sbjct: 1474 -GAEG-----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---- 1523
Query: 295 NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
+ ++A +AR + L AL E ++ ++ E RL E +AR Q
Sbjct: 1524 --RVKAEAEAAREKQRALQALEELRLQAEEAE-------RRLRQAEVERAR------QVQ 1568
Query: 355 VLLET-KTMLEDQLEGTRAR-SDKLHELEK---ENLQLKAKLHDMEMERDMDRKKIEELM 409
V LET + E +L+ RA ++K +LE+ E A+L + R + + E
Sbjct: 1569 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1628
Query: 410 EE-NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
EE LE Q ++ +E+L L + E++++ L++A + E R E
Sbjct: 1629 EEAERELERWQLKA-NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687
Query: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE-------ILENEIVQEKQ-- 519
+ +EL EG A + L E+E RL + E +LE E+ + ++
Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1747
Query: 520 --SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
+ Q Q L +L K +A++E + + E E+ + L R+ ++ +
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 578 AEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA---EELEN 632
A R ++ +++ ++ E ++ ++ EK E K + E A +E EN
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS-FKNLTFQLES 691
E E+E Q++ E Q +++E +L+K DS + +E
Sbjct: 1868 ERLRRLAEDEAFQRRRLE--------EQAAQHKADIEERLAQLRKASDSELERQKGLVED 1919
Query: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
++ Q++EE L L+ + E A+ A+L+LE + S E + E + +
Sbjct: 1920 TLRQRRQVEEEILALKASFEK---AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Query: 752 ERLEVSYQGLDIE-NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
+L + E +R+QK+L + +Q ++ L+++E L+ +EE + +R
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARRLRERA 2032
Query: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKR----LRQQAEIKDTTLEENNVKIGNLEKEN 866
EQ L QE +Q K+L+ E K ++Q+ + TL++ + L E
Sbjct: 2033 EQESARQLQLAQEAAQ-----KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087
Query: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
+ + +E+ V+ + +++ V+ A L++ + Q E
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSAEEQAQARAQAQAAAE 2140
Query: 927 KLTHELEKIGLNK---ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARL 983
KL E E+ + E+ ++ D+ + + E TL++ ++++E + L +L
Sbjct: 2141 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQL 2199
Query: 984 EESTNYNQQLRQELKTVKKNY-EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1042
EE+ + L +EL+ +K EA +QR E + S E +K + + R L+
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2259
Query: 1043 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1102
L + + LQ E + +K + E ++ AQ A RQ L E++ Q
Sbjct: 2260 -----LRDKDNTQRFLQEEAEKMKQVAE--EAARLSVAAQEAARLRQ---LAEEDLAQQR 2309
Query: 1103 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1162
A+ ++ Q + + A+LL QQ L E ++E D + + L ++ +
Sbjct: 2310 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQG 2367
Query: 1163 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-EDLEKMLKV 1221
+ E + + ++ LK + E+ + KQ ++ E L +
Sbjct: 2368 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2427
Query: 1222 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1281
QEK+ L +T+ + ++ + +RL ++L +E E LQ + K L+ L + +++
Sbjct: 2428 TQEKVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQ 2481
Query: 1282 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL 1341
+ E + Q+ ++ + L Q + +E+E L Q + + + L
Sbjct: 2482 TVQQE-------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2534
Query: 1342 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
E+ + E+++ + + E RR++ + EE +
Sbjct: 2535 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2570
Score = 150 bits (379), Expect = 1e-35
Identities = 256/1233 (20%), Positives = 506/1233 (41%), Gaps = 146/1233 (11%)
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA-----RSAR 306
EL KA +++LR + E + + EL + +RLQQ + + R A+
Sbjct: 1128 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1187
Query: 307 MYRDELDALREKAVRVDKLES---EVSRYKERLHDIEFY----KARVEELK----EDNQV 355
+ L + VR +LE ++ Y+E + + + R E+++ D+Q
Sbjct: 1188 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1247
Query: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME--ENM 413
+ E + LE +K+ E ++ Q + D E++ + ++E + +
Sbjct: 1248 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1307
Query: 414 TLEMAQKQSMDESLHLGWELEQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
++ + + E + L +++ TS+ + ++L E + + E E + L
Sbjct: 1308 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1366
Query: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
+ L E +A + E+E + L ++ ++ E+V+ +++ + Q + +
Sbjct: 1367 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR---MQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR------QRSQISAE------- 579
+E QL ++ E + RQ + E+ + + + +R +R + AE
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1483
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLE 638
AR ++ E + + E + ++ KRQ + EL K + E A E + L LE
Sbjct: 1484 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1543
Query: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698
+ LQ + ++ ++E Q LE R + L S K +F ++ + E S
Sbjct: 1544 ELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS-KRASFAEKTAQLERS- 1599
Query: 699 LDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLK-KGLELLK--------ASFK 749
L EE++ + + E + + + A+ + +E E E E+ + K E L+ A K
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1659
Query: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQ----TLQKNL---EE 802
+ E Q + E + ++ + + ++Q E Q+LE + Q T Q+ L +E
Sbjct: 1660 SLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718
Query: 803 LKISSKRLEQLEKENKSLEQETSQLEKD-------KKQLEKENKRLRQQAEI----KDTT 851
L EQ E++ + LE+E ++L+++ +++LE E ++R + E+ K
Sbjct: 1719 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1778
Query: 852 LEENNVKIGNLEKENKTLSKEIGIYK---ESCVRLKELEKENKELVKRATIDIKTLVTLR 908
EE+ EK + L E G ++ E RL+ L +E K + A D
Sbjct: 1779 EEESR---STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1835
Query: 909 EDLVSEKL----KTQQMNNDLEKLTHELEKIGLNKERLLHDE------------------ 946
E +++EKL + ++ + E E E RL DE
Sbjct: 1836 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1895
Query: 947 -------QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
+ DS + + +E TL++ ++ EE+I AL+A E++ +L EL
Sbjct: 1896 EERLAQLRKASDSELERQKGLVEDTLRQRRQV-EEEILALKASFEKAAAGKAELELELGR 1954
Query: 1000 VKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1058
++ N E L+ ++ E ++ E+ + RE++E ++ L ++ E R
Sbjct: 1955 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE---EAARQRKAA 2011
Query: 1059 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1118
E + LK +++ +A+ L + + S ++ + +LQ E ++ +
Sbjct: 2012 LEEVERLKAKVE---------EARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-HAFA 2061
Query: 1119 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1178
Q Q +QQ +SV+ + ++ E+ + ER+A++ +
Sbjct: 2062 VQQKEQELQQTLQQ------EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2115
Query: 1179 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1238
+ LK + + + +L K+ Q E + + E+ L K
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ----EAARRAQAEQAALRQKQAADAEM 2171
Query: 1239 E-YKKLCGENDRLNHTYSQLLK--ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1295
E +KK + R Q L ++ +TDH+ K+LL+ E RL+AE ++ Q
Sbjct: 2172 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ--KNLLDE---ELQRLKAEATEAARQ 2226
Query: 1296 YQQLDITSTKLNNQCELLSQLKGNLEEENRHLL----DQIQTLMLQNRTLLEQNMESKDL 1351
Q++ + Q E LS+LK +E ENR L+ D Q + + ++Q E
Sbjct: 2227 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2286
Query: 1352 FHVEQRQYIDKLNELRR----QKEKLEEKIMDQ 1380
V Q +L +L Q+ L EK++ +
Sbjct: 2287 LSV-AAQEAARLRQLAEEDLAQQRALAEKMLKE 2318
Score = 133 bits (334), Expect = 2e-30
Identities = 205/990 (20%), Positives = 418/990 (42%), Gaps = 146/990 (14%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
T+ ++ + L + +A + + E EL++ R + L + + A+ S
Sbjct: 1726 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1785
Query: 239 GMK---RTESRQHLSVELADAKAKIRRLRQE----------------------LEEKTEQ 273
K R E+ ELA+ A++R L +E L EK
Sbjct: 1786 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1845
Query: 274 LLDCKQELEQMEIELKRLQQENMNL--LSDARSARMYRDELDALREKAVRVDKL------ 325
+ + + + EI LK + EN L L++ + + R E A + KA ++L
Sbjct: 1846 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1905
Query: 326 -ESEVSRYKERLHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARS-DKLHE 379
+SE+ R K + D + +VEE LK + K LE +L R+ + D L
Sbjct: 1906 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965
Query: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE----MAQKQSMDESLHLGWELEQ 435
E+ L+ A+ + E + R++ EE +++++ E +K +++E L ++E+
Sbjct: 1966 KEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2024
Query: 436 ISRTSELSEAPQKSLGHEVNELTSSRL--------LKLEMENQSLTKTVEELRTTVDSVE 487
R E +E E RL ++ + Q L +T+++ ++ +D +
Sbjct: 2025 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084
Query: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE---KAQLEKTIET 544
G A + +E + + E E Q ++ ++ + L + ++ +AQ + E
Sbjct: 2085 GEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2141
Query: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS--- 601
LR+ +E++ Q + ++LRQ+ AE +EK K +++++ +
Sbjct: 2142 LRKEAEQEAARRAQAEQ------AALRQKQAADAE-----MEKHKKFAEQTLRQKAQVEQ 2190
Query: 602 -------KLSKIEFEKRQIKKELEHYK----EKGERAEELENELHHLEKENELLQKKITN 650
+L + + +K + +EL+ K E + ++E EL + + E L K
Sbjct: 2191 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR 2250
Query: 651 LKITCEKIEALEQENSE--LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRR 708
++ + +++N++ L+ E K+K+ + L+ + + QL EE+L +R
Sbjct: 2251 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-QLAEEDLAQQR 2309
Query: 709 NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT-ERLEVSYQGLDIENQR 767
+ K KM +Q E L++E E L++ EL + ++ E E Q L E Q
Sbjct: 2310 ALAE-KMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2367
Query: 768 LQKTLENSNKKIQQLESELQDLEM--------------ENQTLQKNLEELKISSKRLEQL 813
Q+TLE ++ ++ +E + L++ + Q +K EE+ R E
Sbjct: 2368 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2427
Query: 814 EKENKSLEQ-----------ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE-NNVKIGN 861
+E +L Q + +L + +LE+E ++L+Q+A++ EE V+
Sbjct: 2428 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2487
Query: 862 LEKENKTLSKEIGIYKESCV-RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
L +E + L + K+S + R + +E+E +L + ++ LRE+ ++ + QQ
Sbjct: 2488 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE---QQRQQQQ 2544
Query: 921 MNNDLEKLT------------------------HELEKIGLNKERLLHDEQSTDDSRYKL 956
M + ++L +LE+ +E LL +E + +L
Sbjct: 2545 MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2604
Query: 957 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1016
LE + + L S E+ ++AA + L + E + + +++ L+++ +R+
Sbjct: 2605 LEEQHRAALAHSEEVTASQVAATKT-LPNGRDALDGPAAEAEP-EHSFDGLRRKVSAQRL 2662
Query: 1017 VQSSPPISGEDNKWERESQETTRELLKVKD 1046
Q + +S E+ + + T EL + +D
Sbjct: 2663 -QEAGILSAEELQRLAQGHTTVDELARRED 2691
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 176 bits (446), Expect = 2e-43
Identities = 270/1296 (20%), Positives = 536/1296 (41%), Gaps = 115/1296 (8%)
Query: 115 EQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQ 174
+Q EE ++L + Q Q E + + + K +EV +E D Q
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1412
Query: 175 WMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSP 234
+ + QE+++ L ++ ++ + + + + + EE + A+ +
Sbjct: 1413 QQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG- 1469
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294
G+ G Q L +A+A+ R+ ++E E Q+ D Q Q E+EL
Sbjct: 1470 -GAEG-----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---- 1519
Query: 295 NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
+ ++A +AR + L AL E ++ ++ E RL E +AR Q
Sbjct: 1520 --RVKAEAEAAREKQRALQALEELRLQAEEAE-------RRLRQAEVERAR------QVQ 1564
Query: 355 VLLET-KTMLEDQLEGTRAR-SDKLHELEK---ENLQLKAKLHDMEMERDMDRKKIEELM 409
V LET + E +L+ RA ++K +LE+ E A+L + R + + E
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 410 EE-NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
EE LE Q ++ +E+L L + E++++ L++A + E R E
Sbjct: 1625 EEAERELERWQLKA-NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE-------ILENEIVQEKQ-- 519
+ +EL EG A + L E+E RL + E +LE E+ + ++
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 520 --SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
+ Q Q L +L K +A++E + + E E+ + L R+ ++ +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 578 AEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA---EELEN 632
A R ++ +++ ++ E ++ ++ EK E K + E A +E EN
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS-FKNLTFQLES 691
E E+E Q++ E Q +++E +L+K DS + +E
Sbjct: 1864 ERLRRLAEDEAFQRRRLE--------EQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
++ Q++EE L L+ + E A+ A+L+LE + S E + E + +
Sbjct: 1916 TLRQRRQVEEEILALKASFEK---AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 752 ERLEVSYQGLDIE-NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
+L + E +R+QK+L + +Q ++ L+++E L+ +EE + +R
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARRLRERA 2028
Query: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKR----LRQQAEIKDTTLEENNVKIGNLEKEN 866
EQ L QE +Q K+L+ E K ++Q+ + TL++ + L E
Sbjct: 2029 EQESARQLQLAQEAAQ-----KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
+ + +E+ V+ + +++ V+ A L++ + Q E
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSAEEQAQARAQAQAAAE 2136
Query: 927 KLTHELEKIGLNK---ERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARL 983
KL E E+ + E+ ++ D+ + + E TL++ ++++E + L +L
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQL 2195
Query: 984 EESTNYNQQLRQELKTVKKNY-EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1042
EE+ + L +EL+ +K EA +QR E + S E +K + + R L+
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255
Query: 1043 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1102
L + + LQ E + +K + E ++ AQ A RQ L E++ Q
Sbjct: 2256 -----LRDKDNTQRFLQEEAEKMKQVAE--EAARLSVAAQEAARLRQ---LAEEDLAQQR 2305
Query: 1103 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1162
A+ ++ Q + + A+LL QQ L E ++E D + + L ++ +
Sbjct: 2306 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQG 2363
Query: 1163 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-EDLEKMLKV 1221
+ E + + ++ LK + E+ + KQ ++ E L +
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 1222 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1281
QEK+ L +T+ + ++ + +RL ++L +E E LQ + K L+ L + +++
Sbjct: 2424 TQEKVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQ 2477
Query: 1282 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL 1341
+ E + Q+ ++ + L Q + +E+E L Q + + + L
Sbjct: 2478 TVQQE-------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530
Query: 1342 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1377
E+ + E+++ + + E RR++ + EE +
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Score = 150 bits (379), Expect = 1e-35
Identities = 256/1233 (20%), Positives = 506/1233 (41%), Gaps = 146/1233 (11%)
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA-----RSAR 306
EL KA +++LR + E + + EL + +RLQQ + + R A+
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183
Query: 307 MYRDELDALREKAVRVDKLES---EVSRYKERLHDIEFY----KARVEELK----EDNQV 355
+ L + VR +LE ++ Y+E + + + R E+++ D+Q
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243
Query: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME--ENM 413
+ E + LE +K+ E ++ Q + D E++ + ++E + +
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303
Query: 414 TLEMAQKQSMDESLHLGWELEQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
++ + + E + L +++ TS+ + ++L E + + E E + L
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1362
Query: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
+ L E +A + E+E + L ++ ++ E+V+ +++ + Q + +
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR---MQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR------QRSQISAE------- 579
+E QL ++ E + RQ + E+ + + + +R +R + AE
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLE 638
AR ++ E + + E + ++ KRQ + EL K + E A E + L LE
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698
+ LQ + ++ ++E Q LE R + L S K +F ++ + E S
Sbjct: 1540 ELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS-KRASFAEKTAQLERS- 1595
Query: 699 LDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLK-KGLELLK--------ASFK 749
L EE++ + + E + + + A+ + +E E E E+ + K E L+ A K
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1655
Query: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQ----TLQKNL---EE 802
+ E Q + E + ++ + + ++Q E Q+LE + Q T Q+ L +E
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRG-KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 803 LKISSKRLEQLEKENKSLEQETSQLEKD-------KKQLEKENKRLRQQAEI----KDTT 851
L EQ E++ + LE+E ++L+++ +++LE E ++R + E+ K
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1774
Query: 852 LEENNVKIGNLEKENKTLSKEIGIYK---ESCVRLKELEKENKELVKRATIDIKTLVTLR 908
EE+ EK + L E G ++ E RL+ L +E K + A D
Sbjct: 1775 EEESR---STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1831
Query: 909 EDLVSEKL----KTQQMNNDLEKLTHELEKIGLNKERLLHDE------------------ 946
E +++EKL + ++ + E E E RL DE
Sbjct: 1832 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1891
Query: 947 -------QSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 999
+ DS + + +E TL++ ++ EE+I AL+A E++ +L EL
Sbjct: 1892 EERLAQLRKASDSELERQKGLVEDTLRQRRQV-EEEILALKASFEKAAAGKAELELELGR 1950
Query: 1000 VKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1058
++ N E L+ ++ E ++ E+ + RE++E ++ L ++ E R
Sbjct: 1951 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE---EAARQRKAA 2007
Query: 1059 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1118
E + LK +++ +A+ L + + S ++ + +LQ E ++ +
Sbjct: 2008 LEEVERLKAKVE---------EARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-HAFA 2057
Query: 1119 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1178
Q Q +QQ +SV+ + ++ E+ + ER+A++ +
Sbjct: 2058 VQQKEQELQQTLQQ------EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2111
Query: 1179 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1238
+ LK + + + +L K+ Q E + + E+ L K
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ----EAARRAQAEQAALRQKQAADAEM 2167
Query: 1239 E-YKKLCGENDRLNHTYSQLLK--ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1295
E +KK + R Q L ++ +TDH+ K+LL+ E RL+AE ++ Q
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ--KNLLDE---ELQRLKAEATEAARQ 2222
Query: 1296 YQQLDITSTKLNNQCELLSQLKGNLEEENRHLL----DQIQTLMLQNRTLLEQNMESKDL 1351
Q++ + Q E LS+LK +E ENR L+ D Q + + ++Q E
Sbjct: 2223 RSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR 2282
Query: 1352 FHVEQRQYIDKLNELRR----QKEKLEEKIMDQ 1380
V Q +L +L Q+ L EK++ +
Sbjct: 2283 LSV-AAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Score = 133 bits (334), Expect = 2e-30
Identities = 205/990 (20%), Positives = 418/990 (42%), Gaps = 146/990 (14%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
T+ ++ + L + +A + + E EL++ R + L + + A+ S
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781
Query: 239 GMK---RTESRQHLSVELADAKAKIRRLRQE----------------------LEEKTEQ 273
K R E+ ELA+ A++R L +E L EK
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 274 LLDCKQELEQMEIELKRLQQENMNL--LSDARSARMYRDELDALREKAVRVDKL------ 325
+ + + + EI LK + EN L L++ + + R E A + KA ++L
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 326 -ESEVSRYKERLHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARS-DKLHE 379
+SE+ R K + D + +VEE LK + K LE +L R+ + D L
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE----MAQKQSMDESLHLGWELEQ 435
E+ L+ A+ + E + R++ EE +++++ E +K +++E L ++E+
Sbjct: 1962 KEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020
Query: 436 ISRTSELSEAPQKSLGHEVNELTSSRL--------LKLEMENQSLTKTVEELRTTVDSVE 487
R E +E E RL ++ + Q L +T+++ ++ +D +
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE---KAQLEKTIET 544
G A + +E + + E E Q ++ ++ + L + ++ +AQ + E
Sbjct: 2081 GEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSS--- 601
LR+ +E++ Q + ++LRQ+ AE +EK K +++++ +
Sbjct: 2138 LRKEAEQEAARRAQAEQ------AALRQKQAADAE-----MEKHKKFAEQTLRQKAQVEQ 2186
Query: 602 -------KLSKIEFEKRQIKKELEHYK----EKGERAEELENELHHLEKENELLQKKITN 650
+L + + +K + +EL+ K E + ++E EL + + E L K
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR 2246
Query: 651 LKITCEKIEALEQENSE--LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRR 708
++ + +++N++ L+ E K+K+ + L+ + + QL EE+L +R
Sbjct: 2247 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLR-QLAEEDLAQQR 2305
Query: 709 NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT-ERLEVSYQGLDIENQR 767
+ K KM +Q E L++E E L++ EL + ++ E E Q L E Q
Sbjct: 2306 ALAE-KMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363
Query: 768 LQKTLENSNKKIQQLESELQDLEM--------------ENQTLQKNLEELKISSKRLEQL 813
Q+TLE ++ ++ +E + L++ + Q +K EE+ R E
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 814 EKENKSLEQ-----------ETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE-NNVKIGN 861
+E +L Q + +L + +LE+E ++L+Q+A++ EE V+
Sbjct: 2424 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQ 2483
Query: 862 LEKENKTLSKEIGIYKESCV-RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
L +E + L + K+S + R + +E+E +L + ++ LRE+ ++ + QQ
Sbjct: 2484 LLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREE---QQRQQQQ 2540
Query: 921 MNNDLEKLT------------------------HELEKIGLNKERLLHDEQSTDDSRYKL 956
M + ++L +LE+ +E LL +E + +L
Sbjct: 2541 MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQL 2600
Query: 957 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1016
LE + + L S E+ ++AA + L + E + + +++ L+++ +R+
Sbjct: 2601 LEEQHRAALAHSEEVTASQVAATKT-LPNGRDALDGPAAEAEP-EHSFDGLRRKVSAQRL 2658
Query: 1017 VQSSPPISGEDNKWERESQETTRELLKVKD 1046
Q + +S E+ + + T EL + +D
Sbjct: 2659 -QEAGILSAEELQRLAQGHTTVDELARRED 2687
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.124 0.320
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,486,044
Number of Sequences: 37866
Number of extensions: 2893287
Number of successful extensions: 60712
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 815
Number of HSP's successfully gapped in prelim test: 1719
Number of HSP's that attempted gapping in prelim test: 15187
Number of HSP's gapped (non-prelim): 16057
length of query: 1843
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1726
effective length of database: 13,817,196
effective search space: 23848480296
effective search space used: 23848480296
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.