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Search of human proteins with 50726981
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50726981 radical S-adenosyl methionine and flavodoxin
domains 1 [Homo sapiens]
(732 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50726981 radical S-adenosyl methionine and flavodoxin domains... 1517 0.0
gi|224282123 tRNA-yW synthesizing protein 1 homolog B isoform 1 ... 1277 0.0
gi|224282125 tRNA-yW synthesizing protein 1 homolog B isoform 2 ... 671 0.0
gi|127139033 cytochrome P450 reductase [Homo sapiens] 105 1e-22
gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens] 48 3e-05
gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens] 48 4e-05
gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d... 47 6e-05
gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c... 47 6e-05
gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a... 47 6e-05
gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b [... 47 6e-05
gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens] 47 8e-05
gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens] 47 8e-05
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 44 5e-04
gi|103471997 DNA-directed RNA polymerase I A [Homo sapiens] 44 7e-04
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 41 0.005
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 41 0.005
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 41 0.005
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 41 0.005
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 41 0.005
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 41 0.005
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 41 0.005
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 41 0.005
gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 famil... 40 0.008
gi|239756368 PREDICTED: similar to acidic (leucine-rich) nuclear... 39 0.013
gi|239750893 PREDICTED: similar to acidic (leucine-rich) nuclear... 39 0.013
gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 fami... 39 0.017
gi|210147569 acidic (leucine-rich) nuclear phosphoprotein 32 fam... 39 0.017
gi|210147571 acidic (leucine-rich) nuclear phosphoprotein 32 fam... 39 0.017
gi|83716024 kinesin family member 21B [Homo sapiens] 39 0.017
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 39 0.022
>gi|50726981 radical S-adenosyl methionine and flavodoxin domains 1
[Homo sapiens]
Length = 732
Score = 1517 bits (3927), Expect = 0.0
Identities = 732/732 (100%), Positives = 732/732 (100%)
Query: 1 MDPSADTWDLFSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGKNLQEKSVPKAAQD 60
MDPSADTWDLFSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGKNLQEKSVPKAAQD
Sbjct: 1 MDPSADTWDLFSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGKNLQEKSVPKAAQD 60
Query: 61 LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD 120
LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD
Sbjct: 61 LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD 120
Query: 121 HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLG 180
HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLG
Sbjct: 121 HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLG 180
Query: 181 NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL 240
NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL
Sbjct: 181 NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL 240
Query: 241 QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF 300
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF
Sbjct: 241 QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF 300
Query: 301 GGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL 360
GGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
Sbjct: 301 GGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL 360
Query: 361 REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC 420
REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC
Sbjct: 361 REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC 420
Query: 421 VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC 480
VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC
Sbjct: 421 VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC 480
Query: 481 ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS 540
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS
Sbjct: 481 ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS 540
Query: 541 LKKIDRPLFKDFWQRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI 600
LKKIDRPLFKDFWQRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
Sbjct: 541 LKKIDRPLFKDFWQRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI 600
Query: 601 EVKGVTYCGESSASSLTMAHVPWHEEVVQFVHELVDLIPEYEIACEHEHSNCLLIAHRKF 660
EVKGVTYCGESSASSLTMAHVPWHEEVVQFVHELVDLIPEYEIACEHEHSNCLLIAHRKF
Sbjct: 601 EVKGVTYCGESSASSLTMAHVPWHEEVVQFVHELVDLIPEYEIACEHEHSNCLLIAHRKF 660
Query: 661 KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH 720
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH
Sbjct: 661 KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH 720
Query: 721 QRKNKSKAISGC 732
QRKNKSKAISGC
Sbjct: 721 QRKNKSKAISGC 732
>gi|224282123 tRNA-yW synthesizing protein 1 homolog B isoform 1
[Homo sapiens]
Length = 668
Score = 1277 bits (3305), Expect = 0.0
Identities = 638/732 (87%), Positives = 644/732 (87%), Gaps = 64/732 (8%)
Query: 1 MDPSADTWDLFSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGKNLQEKSVPKAAQD 60
MDPSADTWDL SPLISLWINRFYIYLGFAVSISLWICVQIVI+ QG
Sbjct: 1 MDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIEMQG-------------- 46
Query: 61 LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD 120
FATVLAEAVTSLDLPVAIINLKEYDPDD
Sbjct: 47 --------------------------------FATVLAEAVTSLDLPVAIINLKEYDPDD 74
Query: 121 HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLG 180
HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMR AVFGLG
Sbjct: 75 HLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRDAVFGLG 134
Query: 181 NSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKFISQL 240
NSAYASHFNKVGKNVDKWLWMLG HRVMSRGEGDCDVVKSKHGSIEA+FRAWKTKFISQL
Sbjct: 135 NSAYASHFNKVGKNVDKWLWMLGVHRVMSRGEGDCDVVKSKHGSIEANFRAWKTKFISQL 194
Query: 241 QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEF 300
QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGS EQDELHHRDT+EEEPFESSSEEEF
Sbjct: 195 QALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSQEQDELHHRDTKEEEPFESSSEEEF 254
Query: 301 GGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL 360
GGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL
Sbjct: 255 GGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPAL 314
Query: 361 REALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYKHTFYGIESHRCMETTPSLACANKC 420
REALTKQ R R H + ESHRCMETTPSLACANKC
Sbjct: 315 REALTKQ-----------------VDAPRERSLLQTHILWN-ESHRCMETTPSLACANKC 356
Query: 421 VFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC 480
VFCW HH NPVGTEW WKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC
Sbjct: 357 VFCWWHHNNPVGTEWLWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHC 416
Query: 481 ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS 540
ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS
Sbjct: 417 ALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDS 476
Query: 541 LKKIDRPLFKDFWQRFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI 600
LKKIDRPLFKDFWQ+FLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI
Sbjct: 477 LKKIDRPLFKDFWQQFLDSLKALAVKQQRTVYRLTLVKAWNVDELQAYAQLVSLGNPDFI 536
Query: 601 EVKGVTYCGESSASSLTMAHVPWHEEVVQFVHELVDLIPEYEIACEHEHSNCLLIAHRKF 660
EVKGVTYC ESSASSLTMAHVPWHEEVVQFV ELVDLIPEYEIACEHEHSNCLLIAHRKF
Sbjct: 537 EVKGVTYCRESSASSLTMAHVPWHEEVVQFVRELVDLIPEYEIACEHEHSNCLLIAHRKF 596
Query: 661 KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGASERGFDPKDTRH 720
KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGA+ER FDPKDTRH
Sbjct: 597 KIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERSFDPKDTRH 656
Query: 721 QRKNKSKAISGC 732
QRKNKSKAISGC
Sbjct: 657 QRKNKSKAISGC 668
>gi|224282125 tRNA-yW synthesizing protein 1 homolog B isoform 2
[Homo sapiens]
Length = 471
Score = 671 bits (1731), Expect = 0.0
Identities = 343/403 (85%), Positives = 347/403 (86%), Gaps = 27/403 (6%)
Query: 277 EQDELHHRDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEE 336
E D H EEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEE
Sbjct: 69 EYDPDDHLIEEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEE 128
Query: 337 KSGLFRNMGRNEDGERRAMITPALREALTKQGYQLIGSHSGVKLCRWTKSMLRGRGGCYK 396
KSGLFRNMGRNEDGERRAMITPALREALTKQ R R
Sbjct: 129 KSGLFRNMGRNEDGERRAMITPALREALTKQ-----------------VDAPRERSLLQT 171
Query: 397 HTFYGIESHRCMETTPSLACANKCVFCWRHHTNPVGTEWRWKMDQPEMILKEAIENHQNM 456
H + ESHRCMETTPSLACANKCVFCW HH NPVGTEW WKMDQPEMILKEAIENHQNM
Sbjct: 172 HILWN-ESHRCMETTPSLACANKCVFCWWHHNNPVGTEWWWKMDQPEMILKEAIENHQNM 230
Query: 457 IKQFKGVPGVKAERFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQF 516
IKQFKGVPGVKAERFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQF
Sbjct: 231 IKQFKGVPGVKAERFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQF 290
Query: 517 PAEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQRFLDSLKALAVKQQRTVYRLTL 576
PAEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQ+FLDSLKALAVKQQRTVYRLTL
Sbjct: 291 PAEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQQFLDSLKALAVKQQRTVYRLTL 350
Query: 577 VKAWNVDELQAYAQLVSLGNPDFIEVKGVTYCGESSASSLTMAHVPWHEEVVQFVHELVD 636
VKAWNVDELQAYAQLVSLGNPDFIEVKGVTYC ESSASSLTMAHVPWHEEVVQFV ELVD
Sbjct: 351 VKAWNVDELQAYAQLVSLGNPDFIEVKGVTYCRESSASSLTMAHVPWHEEVVQFVRELVD 410
Query: 637 LIPEYEIACEHEHSNCLLIAHRKFKIGG---------EWWTWI 670
LIPEYEIACEHEHSNCLLIAHRK +GG +W WI
Sbjct: 411 LIPEYEIACEHEHSNCLLIAHRKTVLGGTPGHGVTEIQWEEWI 453
Score = 134 bits (336), Expect = 4e-31
Identities = 76/125 (60%), Positives = 77/125 (61%), Gaps = 46/125 (36%)
Query: 1 MDPSADTWDLFSPLISLWINRFYIYLGFAVSISLWICVQIVIKTQGKNLQEKSVPKAAQD 60
MDPSADTWDL SPLISLWINRFYIYLGFAVSISLWICVQIVI+ Q
Sbjct: 1 MDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIEMQ--------------- 45
Query: 61 LMTNGYVSLQEKDIFVSGVKIFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDD 120
GFATVLAEAVTSLDLPVAIINLKEYDPDD
Sbjct: 46 -------------------------------GFATVLAEAVTSLDLPVAIINLKEYDPDD 74
Query: 121 HLIEE 125
HLIEE
Sbjct: 75 HLIEE 79
>gi|127139033 cytochrome P450 reductase [Homo sapiens]
Length = 680
Score = 105 bits (263), Expect = 1e-22
Identities = 63/156 (40%), Positives = 87/156 (55%), Gaps = 14/156 (8%)
Query: 81 IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140
+FYGSQTGTA+ FA L++ + + +EYD D + VF +ATY
Sbjct: 85 VFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYG 144
Query: 141 DGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLW 200
+G PT++A+ F WL+E +D L G+++AVFGLGN Y HFN +GK VDK L
Sbjct: 145 EGDPTDNAQDFYDWLQETDVD-------LSGVKFAVFGLGNKTY-EHFNAMGKYVDKRLE 196
Query: 201 MLGAHRVMSRGEGDCDVVKSKHGSIEADFRAWKTKF 236
LGA R+ G GD D G++E DF W+ +F
Sbjct: 197 QLGAQRIFELGLGDDD------GNLEEDFITWREQF 226
>gi|10835173 nitric oxide synthase 1, neuronal [Homo sapiens]
Length = 1434
Score = 48.1 bits (113), Expect = 3e-05
Identities = 50/190 (26%), Positives = 77/190 (40%), Gaps = 48/190 (25%)
Query: 81 IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140
I Y ++TG ++ +A L E + +++++EYD I + + + + + +T+
Sbjct: 762 ILYATETGKSQAYAKTLCE-IFKHAFDAKVMSMEEYD-----IVHLEHETLVLVVTSTFG 815
Query: 141 DGLPTESAEWF-CKWLE----------EASIDFRFGKTY--------------------- 168
+G P E+ E F C +E S RF
Sbjct: 816 NGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSQKSSGDGPDLRDNFES 875
Query: 169 ---LKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGDCDVVKSKHGSI 225
L +R++VFGLG+ AY HF G VD L LG R++ EGD G
Sbjct: 876 AGPLANVRFSVFGLGSRAYP-HFCAFGHAVDTLLEELGGERILKMREGD-----ELCGQE 929
Query: 226 EADFRAWKTK 235
EA FR W K
Sbjct: 930 EA-FRTWAKK 938
>gi|40254422 nitric oxide synthase 3 isoform 1 [Homo sapiens]
Length = 1203
Score = 47.8 bits (112), Expect = 4e-05
Identities = 49/191 (25%), Positives = 78/191 (40%), Gaps = 47/191 (24%)
Query: 81 IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140
I YGS+TG A+ +A L P ++ + EYD + + + + + + +T+
Sbjct: 522 ILYGSETGRAQSYAQQLGRLFRKAFDP-RVLCMDEYD-----VVSLEHETLVLVVTSTFG 575
Query: 141 DGLPTESAEWFCKWLEEASIDFRFG------KTY-------------------------- 168
+G P E+ E F L E S + K+Y
Sbjct: 576 NGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSISCSDPLVSSWRRKRKESSN 635
Query: 169 ------LKGMRYAVFGLGNSAYASHFNKVGKNVDKWLWMLGAHRVMSRGEGD--CDVVKS 220
L +R+ VFGLG+ AY HF + VD L LG R++ G+GD C ++
Sbjct: 636 TDSAGALGTLRFCVFGLGSRAYP-HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEA 694
Query: 221 KHGSIEADFRA 231
G +A F+A
Sbjct: 695 FRGWAQAAFQA 705
>gi|221316707 NADPH dependent diflavin oxidoreductase 1 isoform d
[Homo sapiens]
Length = 521
Score = 47.0 bits (110), Expect = 6e-05
Identities = 41/134 (30%), Positives = 65/134 (48%), Gaps = 10/134 (7%)
Query: 81 IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140
+ +GSQTGTA+ + L L + L Y P +LI E + +F+ AT
Sbjct: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSY-PVVNLINEP----LVIFVCATTG 62
Query: 141 DGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLW 200
G P ++ + F +++ ++ T L M +AV GLG+S+YA FN V K + + L
Sbjct: 63 QGDPPDNMKNFWRFIFRKNLP----STALCQMDFAVLGLGDSSYAK-FNFVAKKLHRRLL 117
Query: 201 MLGAHRVMSRGEGD 214
LG ++ GD
Sbjct: 118 QLGGSALLPVCLGD 131
>gi|221316709 NADPH dependent diflavin oxidoreductase 1 isoform c
[Homo sapiens]
Length = 590
Score = 47.0 bits (110), Expect = 6e-05
Identities = 41/134 (30%), Positives = 65/134 (48%), Gaps = 10/134 (7%)
Query: 81 IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140
+ +GSQTGTA+ + L L + L Y P +LI E + +F+ AT
Sbjct: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSY-PVVNLINEP----LVIFVCATTG 62
Query: 141 DGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLW 200
G P ++ + F +++ ++ T L M +AV GLG+S+YA FN V K + + L
Sbjct: 63 QGDPPDNMKNFWRFIFRKNLP----STALCQMDFAVLGLGDSSYAK-FNFVAKKLHRRLL 117
Query: 201 MLGAHRVMSRGEGD 214
LG ++ GD
Sbjct: 118 QLGGSALLPVCLGD 131
>gi|221316705 NADPH dependent diflavin oxidoreductase 1 isoform a
[Homo sapiens]
Length = 606
Score = 47.0 bits (110), Expect = 6e-05
Identities = 41/134 (30%), Positives = 65/134 (48%), Gaps = 10/134 (7%)
Query: 81 IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140
+ +GSQTGTA+ + L L + L Y P +LI E + +F+ AT
Sbjct: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSY-PVVNLINEP----LVIFVCATTG 62
Query: 141 DGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLW 200
G P ++ + F +++ ++ T L M +AV GLG+S+YA FN V K + + L
Sbjct: 63 QGDPPDNMKNFWRFIFRKNLP----STALCQMDFAVLGLGDSSYAK-FNFVAKKLHRRLL 117
Query: 201 MLGAHRVMSRGEGD 214
LG ++ GD
Sbjct: 118 QLGGSALLPVCLGD 131
>gi|7657393 NADPH dependent diflavin oxidoreductase 1 isoform b
[Homo sapiens]
Length = 597
Score = 47.0 bits (110), Expect = 6e-05
Identities = 41/134 (30%), Positives = 65/134 (48%), Gaps = 10/134 (7%)
Query: 81 IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140
+ +GSQTGTA+ + L L + L Y P +LI E + +F+ AT
Sbjct: 8 VLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSY-PVVNLINEP----LVIFVCATTG 62
Query: 141 DGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLW 200
G P ++ + F +++ ++ T L M +AV GLG+S+YA FN V K + + L
Sbjct: 63 QGDPPDNMKNFWRFIFRKNLP----STALCQMDFAVLGLGDSSYAK-FNFVAKKLHRRLL 117
Query: 201 MLGAHRVMSRGEGD 214
LG ++ GD
Sbjct: 118 QLGGSALLPVCLGD 131
>gi|169790958 methionine synthase reductase isoform 1 [Homo sapiens]
Length = 698
Score = 46.6 bits (109), Expect = 8e-05
Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 9/134 (6%)
Query: 81 IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140
+ Y +Q G AK A + E + + E D D E V +V+T
Sbjct: 6 LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAP----LVVVVSTTG 61
Query: 141 DGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLW 200
G P ++A F K ++ ++ F +RY + GLG+S Y ++F GK +DK L
Sbjct: 62 TGDPPDTARKFVKEIQNQTLPVDF----FAHLRYGLLGLGDSEY-TYFCNGGKIIDKRLQ 116
Query: 201 MLGAHRVMSRGEGD 214
LGA G D
Sbjct: 117 ELGARHFYDTGHAD 130
>gi|169790956 methionine synthase reductase isoform 2 [Homo sapiens]
Length = 725
Score = 46.6 bits (109), Expect = 8e-05
Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 9/134 (6%)
Query: 81 IFYGSQTGTAKGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYT 140
+ Y +Q G AK A + E + + E D D E V +V+T
Sbjct: 33 LLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLKTETAP----LVVVVSTTG 88
Query: 141 DGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRYAVFGLGNSAYASHFNKVGKNVDKWLW 200
G P ++A F K ++ ++ F +RY + GLG+S Y ++F GK +DK L
Sbjct: 89 TGDPPDTARKFVKEIQNQTLPVDF----FAHLRYGLLGLGDSEY-TYFCNGGKIIDKRLQ 143
Query: 201 MLGAHRVMSRGEGD 214
LGA G D
Sbjct: 144 ELGARHFYDTGHAD 157
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 43.9 bits (102), Expect = 5e-04
Identities = 29/107 (27%), Positives = 51/107 (47%), Gaps = 5/107 (4%)
Query: 245 KGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEFGGED 304
+GER+K G K+ + + G EE ++G E++E R E+EE E GGE
Sbjct: 765 EGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEE-----GGEVEGGEV 819
Query: 305 HQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGE 351
+ + E+ G+ + + + E+ + EE+ G + E+GE
Sbjct: 820 EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGE 866
Score = 42.4 bits (98), Expect = 0.002
Identities = 31/100 (31%), Positives = 46/100 (46%), Gaps = 10/100 (10%)
Query: 254 GHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEFGGEDHQSLNSIVD 313
G ++G+ E + G E EEG E +E EEE E EEE GE + +
Sbjct: 957 GEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEE--GEGEEEGEGEGE 1014
Query: 314 VEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERR 353
E+ G++ V+ E+ E E +EE+ E+GE R
Sbjct: 1015 EEEEGEVEGEVEGEEGEGEGEEEEG--------EEEGEER 1046
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/108 (30%), Positives = 52/108 (48%), Gaps = 15/108 (13%)
Query: 244 QKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEFGGE 303
++ E+K+ GH K+ E + G EE EG E+ D EEEE E +EE GE
Sbjct: 708 EEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEG-----DREEEEEKEGEGKEEGEGE 762
Query: 304 DHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGE 351
+ V+ E + + K+E+ KE++ E+ G + G E+ E
Sbjct: 763 E-------VEGEREKEEGERKKEERAGKEEKGEEEG---DQGEGEEEE 800
Score = 38.5 bits (88), Expect = 0.022
Identities = 36/119 (30%), Positives = 53/119 (44%), Gaps = 16/119 (13%)
Query: 245 KGERKKSCG----GHCKKGKC---ESHQHGSEEREEGSHEQDELHHRDTE-----EEEPF 292
+GE K+ G G ++GK E + G E EEG E++E + E EEE
Sbjct: 804 RGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE 863
Query: 293 ESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGE 351
E EEE GE+ + + E G+ + E+ E E + E+ G G E+GE
Sbjct: 864 EGEGEEE--GEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEG--EGEGEEEEGE 918
Score = 37.7 bits (86), Expect = 0.038
Identities = 38/145 (26%), Positives = 63/145 (43%), Gaps = 32/145 (22%)
Query: 210 RGEGDCDVVKSKHGSIEADFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQHGSE 269
RG+G C+ GS A+ W Q + +KGE+ K G + G+ E E
Sbjct: 654 RGDGTCE-----EGSSGAEH--W------QDEEREKGEKDKGRGEMERPGEGEKELAEKE 700
Query: 270 EREEGSHEQDELHHRDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKR 329
E ++ E+ E R+ ++ E + E E GGE+ ++E+
Sbjct: 701 EWKKRDGEEQEQKEREQGHQK--ERNQEMEEGGEEEHGEG---------------EEEEG 743
Query: 330 EKEQQEEKSGLFRNMGRNE--DGER 352
++E++EEK G + G E +GER
Sbjct: 744 DREEEEEKEGEGKEEGEGEEVEGER 768
Score = 37.4 bits (85), Expect = 0.050
Identities = 37/151 (24%), Positives = 70/151 (46%), Gaps = 14/151 (9%)
Query: 211 GEGDCDVVKSKHGSIEADFRAWKTKFISQLQALQKGERKKSCG-GHCKKGKCESHQHGSE 269
GEG+ + + + E ++ + + + + +GE ++ G G ++G+ E + E
Sbjct: 937 GEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE 996
Query: 270 ER--EEGSHEQDELHHRDTEEEEPFESSSEEEFG---GEDHQSLNSIVDVEDLGKIMDHV 324
E EEG E++ + EEE E E E G GE+ + + E G+
Sbjct: 997 EEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGE----G 1052
Query: 325 KKEKREKEQQEEKSGLFRNMGRNE----DGE 351
++ +R +E++EE+ G ++ G E DGE
Sbjct: 1053 EENRRNREEEEEEEGKYQETGEEENERQDGE 1083
Score = 37.0 bits (84), Expect = 0.065
Identities = 32/119 (26%), Positives = 49/119 (41%), Gaps = 16/119 (13%)
Query: 245 KGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTE------------EEEPF 292
+GE + G ++G+ + + G E EG E+ E D E EEE
Sbjct: 903 EGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEG 962
Query: 293 ESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGE 351
E EEE GE + + E G+ ++E+ E+E +EE G G E+ E
Sbjct: 963 EGEGEEEGEGEGEEGEGEGEEEEGEGE----GEEEEGEEEGEEEGEGEEEGEGEGEEEE 1017
Score = 34.7 bits (78), Expect = 0.32
Identities = 32/112 (28%), Positives = 50/112 (44%), Gaps = 8/112 (7%)
Query: 244 QKGERKKSCG-GHCKKGKCESHQ---HGSEEREEGSHEQDELHHRDTEEEEPFESSSEEE 299
++GE ++ G G ++G+ E + G EE EEG E++ EEE E EEE
Sbjct: 831 EEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEE 890
Query: 300 FGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGE 351
GE + E+ + + E + +E+ EE G G E+GE
Sbjct: 891 GEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEG----EGEEEEGE 938
Score = 33.5 bits (75), Expect = 0.72
Identities = 32/109 (29%), Positives = 48/109 (44%), Gaps = 7/109 (6%)
Query: 244 QKGERKKSCGGHCKKGKCESHQ-HGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEFGG 302
++GE K G +G+ E + G E EEG E +E + EEEE E EEE G
Sbjct: 852 EEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEG-EGEGEEEGEG 910
Query: 303 EDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGE 351
E + + E G+ + + E+E+ E + G E+GE
Sbjct: 911 EGEEE-----EGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGE 954
Score = 33.5 bits (75), Expect = 0.72
Identities = 20/69 (28%), Positives = 35/69 (50%), Gaps = 4/69 (5%)
Query: 262 ESHQHGSEEREEGSHEQDELHHRDTEEEE-PFESSSEEE---FGGEDHQSLNSIVDVEDL 317
E + G E +EG E++ + + EEEE ++ + EEE GE+++ ++ I
Sbjct: 1038 EGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKY 1097
Query: 318 GKIMDHVKK 326
GK + KK
Sbjct: 1098 GKHKTYQKK 1106
Score = 32.0 bits (71), Expect = 2.1
Identities = 23/83 (27%), Positives = 36/83 (43%), Gaps = 3/83 (3%)
Query: 258 KGKCESHQHGSEERE---EGSHEQDELHHRDTEEEEPFESSSEEEFGGEDHQSLNSIVDV 314
+G+ E G EE E EG E +E EEE E E+ G + N +
Sbjct: 1004 EGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEE 1063
Query: 315 EDLGKIMDHVKKEKREKEQQEEK 337
E+ GK + ++E ++ +E K
Sbjct: 1064 EEEGKYQETGEEENERQDGEEYK 1086
>gi|103471997 DNA-directed RNA polymerase I A [Homo sapiens]
Length = 1720
Score = 43.5 bits (101), Expect = 7e-04
Identities = 39/140 (27%), Positives = 62/140 (44%), Gaps = 12/140 (8%)
Query: 218 VKSKHGSIEADFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHE 277
+K K+ A FR T+ +Q GE +S G + E H +E E +
Sbjct: 1354 IKKKNNKASA-FRNVNTRRATQRDLDNAGELGRSRGEQEGDEEEEGHIVDAEAEEGDADA 1412
Query: 278 QDELHHRDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEK 337
D EEE +ES EEE GE++ D ED+ + + ++ R+ ++Q+E+
Sbjct: 1413 SDAKRKEKQEEEVDYESEEEEEREGEEN-------DDEDMQEERNPHREGARKTQEQDEE 1465
Query: 338 SGLFRNMGRNEDGERRAMIT 357
GL G ED A++T
Sbjct: 1466 VGL----GTEEDPSLPALLT 1481
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 10/137 (7%)
Query: 237 ISQLQALQKGERKKSCGGHCKKGKCESHQHGS----EEREEGSHEQDELHHRDTEEEEPF 292
+S LQ + ERK S + S + GS EE EE E++ ++EEEE
Sbjct: 251 LSDLQDISDSERKTS------SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 304
Query: 293 ESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGER 352
E EEE G ++ + ++ + ++E +S R+ G +E+ E
Sbjct: 305 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 364
Query: 353 RAMITPALREALTKQGY 369
ALT+ Y
Sbjct: 365 EVGEGTPQSSALTEGDY 381
Score = 31.2 bits (69), Expect = 3.6
Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 271 REEGSHEQDELHH----RDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKK 326
+EE E+D L D+E + SS E G + + E+ G + ++
Sbjct: 241 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 300
Query: 327 EKREKEQQEEKSG 339
E+ E+E++EE++G
Sbjct: 301 EEEEEEEEEEETG 313
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 10/137 (7%)
Query: 237 ISQLQALQKGERKKSCGGHCKKGKCESHQHGS----EEREEGSHEQDELHHRDTEEEEPF 292
+S LQ + ERK S + S + GS EE EE E++ ++EEEE
Sbjct: 261 LSDLQDISDSERKTS------SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 314
Query: 293 ESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGER 352
E EEE G ++ + ++ + ++E +S R+ G +E+ E
Sbjct: 315 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 374
Query: 353 RAMITPALREALTKQGY 369
ALT+ Y
Sbjct: 375 EVGEGTPQSSALTEGDY 391
Score = 33.1 bits (74), Expect = 0.94
Identities = 25/130 (19%), Positives = 48/130 (36%), Gaps = 2/130 (1%)
Query: 257 KKGKCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEFGGEDHQSLNSIVDVED 316
+K KC H H +E + ++ E R EE + + E+ + + + +
Sbjct: 105 RKEKCRHHSHSAEGGKHARVKEREHERRKRHREE--QDKARREWERQKRREMAREHSRRE 162
Query: 317 LGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPALREALTKQGYQLIGSHS 376
++ +K +RE++ +E++ R E R A RE
Sbjct: 163 RDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSD 222
Query: 377 GVKLCRWTKS 386
VK W++S
Sbjct: 223 KVKASHWSRS 232
Score = 31.2 bits (69), Expect = 3.6
Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 271 REEGSHEQDELHH----RDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKK 326
+EE E+D L D+E + SS E G + + E+ G + ++
Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 310
Query: 327 EKREKEQQEEKSG 339
E+ E+E++EE++G
Sbjct: 311 EEEEEEEEEEETG 323
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 10/137 (7%)
Query: 237 ISQLQALQKGERKKSCGGHCKKGKCESHQHGS----EEREEGSHEQDELHHRDTEEEEPF 292
+S LQ + ERK S + S + GS EE EE E++ ++EEEE
Sbjct: 252 LSDLQDISDSERKTS------SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 305
Query: 293 ESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGER 352
E EEE G ++ + ++ + ++E +S R+ G +E+ E
Sbjct: 306 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 365
Query: 353 RAMITPALREALTKQGY 369
ALT+ Y
Sbjct: 366 EVGEGTPQSSALTEGDY 382
Score = 31.2 bits (69), Expect = 3.6
Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 271 REEGSHEQDELHH----RDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKK 326
+EE E+D L D+E + SS E G + + E+ G + ++
Sbjct: 242 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 301
Query: 327 EKREKEQQEEKSG 339
E+ E+E++EE++G
Sbjct: 302 EEEEEEEEEEETG 314
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 10/137 (7%)
Query: 237 ISQLQALQKGERKKSCGGHCKKGKCESHQHGS----EEREEGSHEQDELHHRDTEEEEPF 292
+S LQ + ERK S + S + GS EE EE E++ ++EEEE
Sbjct: 261 LSDLQDISDSERKTS------SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 314
Query: 293 ESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGER 352
E EEE G ++ + ++ + ++E +S R+ G +E+ E
Sbjct: 315 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 374
Query: 353 RAMITPALREALTKQGY 369
ALT+ Y
Sbjct: 375 EVGEGTPQSSALTEGDY 391
Score = 31.2 bits (69), Expect = 3.6
Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 271 REEGSHEQDELHH----RDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKK 326
+EE E+D L D+E + SS E G + + E+ G + ++
Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 310
Query: 327 EKREKEQQEEKSG 339
E+ E+E++EE++G
Sbjct: 311 EEEEEEEEEEETG 323
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 10/137 (7%)
Query: 237 ISQLQALQKGERKKSCGGHCKKGKCESHQHGS----EEREEGSHEQDELHHRDTEEEEPF 292
+S LQ + ERK S + S + GS EE EE E++ ++EEEE
Sbjct: 229 LSDLQDISDSERKTS------SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 282
Query: 293 ESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGER 352
E EEE G ++ + ++ + ++E +S R+ G +E+ E
Sbjct: 283 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 342
Query: 353 RAMITPALREALTKQGY 369
ALT+ Y
Sbjct: 343 EVGEGTPQSSALTEGDY 359
Score = 31.2 bits (69), Expect = 3.6
Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 271 REEGSHEQDELHH----RDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKK 326
+EE E+D L D+E + SS E G + + E+ G + ++
Sbjct: 219 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 278
Query: 327 EKREKEQQEEKSG 339
E+ E+E++EE++G
Sbjct: 279 EEEEEEEEEEETG 291
Score = 30.4 bits (67), Expect = 6.1
Identities = 32/145 (22%), Positives = 62/145 (42%), Gaps = 12/145 (8%)
Query: 244 QKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEE-EEPFESSSEEEFGG 302
+K E++K H + E +H + +E HE+ + H + ++ +E E
Sbjct: 66 RKDEKRKEKRRH-RSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAR 124
Query: 303 EDHQSLNSIVDVEDLGKIMDHVKK-EKREKEQQEEKSGLFRNMGRNEDGERRAMITPALR 361
E S +E L + + +K +++KEQ+E+K R R ++ E R ++ R
Sbjct: 125 E--HSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR 182
Query: 362 EALTKQGYQLIGSHSGVKLCRWTKS 386
++ Y VK W++S
Sbjct: 183 --TMREDYS-----DKVKASHWSRS 200
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 10/137 (7%)
Query: 237 ISQLQALQKGERKKSCGGHCKKGKCESHQHGS----EEREEGSHEQDELHHRDTEEEEPF 292
+S LQ + ERK S + S + GS EE EE E++ ++EEEE
Sbjct: 218 LSDLQDISDSERKTS------SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 271
Query: 293 ESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGER 352
E EEE G ++ + ++ + ++E +S R+ G +E+ E
Sbjct: 272 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 331
Query: 353 RAMITPALREALTKQGY 369
ALT+ Y
Sbjct: 332 EVGEGTPQSSALTEGDY 348
Score = 31.2 bits (69), Expect = 3.6
Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 271 REEGSHEQDELHH----RDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKK 326
+EE E+D L D+E + SS E G + + E+ G + ++
Sbjct: 208 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 267
Query: 327 EKREKEQQEEKSG 339
E+ E+E++EE++G
Sbjct: 268 EEEEEEEEEEETG 280
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 10/137 (7%)
Query: 237 ISQLQALQKGERKKSCGGHCKKGKCESHQHGS----EEREEGSHEQDELHHRDTEEEEPF 292
+S LQ + ERK S + S + GS EE EE E++ ++EEEE
Sbjct: 7 LSDLQDISDSERKTS------SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60
Query: 293 ESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGER 352
E EEE G ++ + ++ + ++E +S R+ G +E+ E
Sbjct: 61 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120
Query: 353 RAMITPALREALTKQGY 369
ALT+ Y
Sbjct: 121 EVGEGTPQSSALTEGDY 137
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 40.8 bits (94), Expect = 0.005
Identities = 34/137 (24%), Positives = 55/137 (40%), Gaps = 10/137 (7%)
Query: 237 ISQLQALQKGERKKSCGGHCKKGKCESHQHGS----EEREEGSHEQDELHHRDTEEEEPF 292
+S LQ + ERK S + S + GS EE EE E++ ++EEEE
Sbjct: 263 LSDLQDISDSERKTS------SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 316
Query: 293 ESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGER 352
E EEE G ++ + ++ + ++E +S R+ G +E+ E
Sbjct: 317 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 376
Query: 353 RAMITPALREALTKQGY 369
ALT+ Y
Sbjct: 377 EVGEGTPQSSALTEGDY 393
Score = 31.2 bits (69), Expect = 3.6
Identities = 19/73 (26%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 271 REEGSHEQDELHH----RDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKK 326
+EE E+D L D+E + SS E G + + E+ G + ++
Sbjct: 253 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 312
Query: 327 EKREKEQQEEKSG 339
E+ E+E++EE++G
Sbjct: 313 EEEEEEEEEEETG 325
Score = 30.4 bits (67), Expect = 6.1
Identities = 32/145 (22%), Positives = 62/145 (42%), Gaps = 12/145 (8%)
Query: 244 QKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDTEE-EEPFESSSEEEFGG 302
+K E++K H + E +H + +E HE+ + H + ++ +E E
Sbjct: 100 RKDEKRKEKRRH-RSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAR 158
Query: 303 EDHQSLNSIVDVEDLGKIMDHVKK-EKREKEQQEEKSGLFRNMGRNEDGERRAMITPALR 361
E S +E L + + +K +++KEQ+E+K R R ++ E R ++ R
Sbjct: 159 E--HSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHR 216
Query: 362 EALTKQGYQLIGSHSGVKLCRWTKS 386
++ Y VK W++S
Sbjct: 217 --TMREDYS-----DKVKASHWSRS 234
>gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 family,
member A [Homo sapiens]
Length = 249
Score = 40.0 bits (92), Expect = 0.008
Identities = 33/125 (26%), Positives = 52/125 (41%), Gaps = 9/125 (7%)
Query: 228 DFRAWKTKFISQLQALQKGERK-KSCGGHCKKGKCESHQHGSEEREEGSHEQDELHHRDT 286
D+R K + QL L +R K +G E E+ +E +++D D
Sbjct: 130 DYRENVFKLLPQLTYLDGYDRDDKEAPDSDAEGYVEGLDDEEEDEDEEEYDEDAQVVEDE 189
Query: 287 EEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGR 346
E+E+ E EE+ GE+ + D E V E+ E+E EE+ G R
Sbjct: 190 EDEDEEEEGEEEDVSGEEEEDEEGYNDGE--------VDDEEDEEELGEEERGQKRKREP 241
Query: 347 NEDGE 351
++GE
Sbjct: 242 EDEGE 246
>gi|239756368 PREDICTED: similar to acidic (leucine-rich) nuclear
phosphoprotein 32 family, member B [Homo sapiens]
Length = 272
Score = 39.3 bits (90), Expect = 0.013
Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 2/83 (2%)
Query: 269 EEREEGSHEQDELHHRDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEK 328
EE EEG E+D + EEE E +E+ G+D + S + E+ G D E
Sbjct: 189 EEDEEGEDEKDXENEDGEEEELDEEEDEDEDVEGDDDKDEVS-EEEEEFGLDKDE-DDED 246
Query: 329 REKEQQEEKSGLFRNMGRNEDGE 351
+++++EE+SG N R D E
Sbjct: 247 EDEDEEEEESGKGENRKRETDDE 269
Score = 32.0 bits (71), Expect = 2.1
Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 11/83 (13%)
Query: 260 KCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEFG---GEDHQSLNSIVDVED 316
K ++ G EE + ++DE D +++E S EEEFG ED + + + E+
Sbjct: 198 KDXENEDGEEEELDEEEDEDEDVEGDDDKDE--VSEEEEEFGLDKDEDDEDEDEDEEEEE 255
Query: 317 LGKIMDHVKKEKREKEQQEEKSG 339
G K E R++E +E+ G
Sbjct: 256 SG------KGENRKRETDDEEDG 272
>gi|239750893 PREDICTED: similar to acidic (leucine-rich) nuclear
phosphoprotein 32 family, member B [Homo sapiens]
Length = 272
Score = 39.3 bits (90), Expect = 0.013
Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 2/83 (2%)
Query: 269 EEREEGSHEQDELHHRDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEK 328
EE EEG E+D + EEE E +E+ G+D + S + E+ G D E
Sbjct: 189 EEDEEGEDEKDXENEDGEEEELDEEEDEDEDVEGDDDKDEVS-EEEEEFGLDKDE-DDED 246
Query: 329 REKEQQEEKSGLFRNMGRNEDGE 351
+++++EE+SG N R D E
Sbjct: 247 EDEDEEEEESGKGENRKRETDDE 269
Score = 32.0 bits (71), Expect = 2.1
Identities = 24/83 (28%), Positives = 40/83 (48%), Gaps = 11/83 (13%)
Query: 260 KCESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEFG---GEDHQSLNSIVDVED 316
K ++ G EE + ++DE D +++E S EEEFG ED + + + E+
Sbjct: 198 KDXENEDGEEEELDEEEDEDEDVEGDDDKDE--VSEEEEEFGLDKDEDDEDEDEDEEEEE 255
Query: 317 LGKIMDHVKKEKREKEQQEEKSG 339
G K E R++E +E+ G
Sbjct: 256 SG------KGENRKRETDDEEDG 272
>gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 family,
member E isoform 1 [Homo sapiens]
Length = 268
Score = 38.9 bits (89), Expect = 0.017
Identities = 29/88 (32%), Positives = 42/88 (47%), Gaps = 6/88 (6%)
Query: 269 EEREEGSHEQDELHHRDTEEEEPFESSSEEEFG-----GEDHQSLNSIVDVEDLGKIMDH 323
EE E G E E + EEE+ E E+E G GE+ L+ ++ E + D
Sbjct: 174 EENEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDD 233
Query: 324 VKKEKREKEQQEEKSGLFRNMGRNEDGE 351
E+ E+E++EE+ GL R R D E
Sbjct: 234 DYVEEGEEEEEEEEGGL-RGEKRKRDAE 260
>gi|210147569 acidic (leucine-rich) nuclear phosphoprotein 32
family, member E isoform 2 [Homo sapiens]
Length = 227
Score = 38.9 bits (89), Expect = 0.017
Identities = 29/88 (32%), Positives = 42/88 (47%), Gaps = 6/88 (6%)
Query: 269 EEREEGSHEQDELHHRDTEEEEPFESSSEEEFG-----GEDHQSLNSIVDVEDLGKIMDH 323
EE E G E E + EEE+ E E+E G GE+ L+ ++ E + D
Sbjct: 133 EENEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDD 192
Query: 324 VKKEKREKEQQEEKSGLFRNMGRNEDGE 351
E+ E+E++EE+ GL R R D E
Sbjct: 193 DYVEEGEEEEEEEEGGL-RGEKRKRDAE 219
>gi|210147571 acidic (leucine-rich) nuclear phosphoprotein 32
family, member E isoform 3 [Homo sapiens]
Length = 220
Score = 38.9 bits (89), Expect = 0.017
Identities = 29/88 (32%), Positives = 42/88 (47%), Gaps = 6/88 (6%)
Query: 269 EEREEGSHEQDELHHRDTEEEEPFESSSEEEFG-----GEDHQSLNSIVDVEDLGKIMDH 323
EE E G E E + EEE+ E E+E G GE+ L+ ++ E + D
Sbjct: 126 EENEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYLMKEEIQDEEDDD 185
Query: 324 VKKEKREKEQQEEKSGLFRNMGRNEDGE 351
E+ E+E++EE+ GL R R D E
Sbjct: 186 DYVEEGEEEEEEEEGGL-RGEKRKRDAE 212
>gi|83716024 kinesin family member 21B [Homo sapiens]
Length = 1624
Score = 38.9 bits (89), Expect = 0.017
Identities = 36/138 (26%), Positives = 60/138 (43%), Gaps = 22/138 (15%)
Query: 237 ISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSHEQDE-------LHHRDTEEE 289
+ +L+ + +R+KS K + + Q SEE +E E++E + E+
Sbjct: 548 LERLKKKEVRQRRKSPEKEAFKKRAKLQQENSEETDENEAEEEEEERDESGCEEEEGRED 607
Query: 290 EPFESSSEEEFGGED----HQSLNSIVDVEDL-------GKIMDHVKKEKRE----KEQQ 334
E +S SEE D + +N D+ DL K++D ++ +R K Q
Sbjct: 608 EDEDSGSEESLVDSDSDPEEKEVNFQADLADLTCEIEIKQKLIDELENSQRRLQTLKHQY 667
Query: 335 EEKSGLFRNMGRNEDGER 352
EEK L +N R+ ER
Sbjct: 668 EEKLILLQNKIRDTQLER 685
>gi|155030232 proline, glutamic acid and leucine rich protein 1
[Homo sapiens]
Length = 1130
Score = 38.5 bits (88), Expect = 0.022
Identities = 21/76 (27%), Positives = 38/76 (50%), Gaps = 7/76 (9%)
Query: 262 ESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIM 321
E + EE EE E+++ + +EEE FE EEE E+ E+ G++
Sbjct: 891 EEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFE-------EEEGELE 943
Query: 322 DHVKKEKREKEQQEEK 337
+ ++E E+E++ E+
Sbjct: 944 EEEEEEDEEEEEELEE 959
Score = 32.7 bits (73), Expect = 1.2
Identities = 19/56 (33%), Positives = 26/56 (46%)
Query: 262 ESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDL 317
E + E+ EE E++E EE E E EEE ED + + +VEDL
Sbjct: 908 EDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDL 963
Score = 32.0 bits (71), Expect = 2.1
Identities = 17/54 (31%), Positives = 25/54 (46%)
Query: 262 ESHQHGSEEREEGSHEQDELHHRDTEEEEPFESSSEEEFGGEDHQSLNSIVDVE 315
E + EE E E++E + EEEE EEE E+ + L + D+E
Sbjct: 911 EEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLE 964
Score = 31.6 bits (70), Expect = 2.7
Identities = 29/101 (28%), Positives = 41/101 (40%), Gaps = 3/101 (2%)
Query: 270 EREEGSHEQDELHHRDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKR 329
E EEG E++E D EEEE E + EFG + L + + +
Sbjct: 936 EEEEGELEEEE-EEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPK 994
Query: 330 EKEQQEEKSGLFRNMGR-NEDGERRAMITPALR-EALTKQG 368
+ + E + GL + + ER A P L EAL QG
Sbjct: 995 VQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQG 1035
Score = 30.8 bits (68), Expect = 4.7
Identities = 21/72 (29%), Positives = 34/72 (47%), Gaps = 3/72 (4%)
Query: 281 LHHRDTEEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQ-EEKSG 339
++ D EEEE E EEE E+ + + ED + + ++E+ E E++ EE+ G
Sbjct: 883 INSSDEEEEEEEEEEEEEEEEEEEEEDFEE--EEEDEEEYFEEEEEEEEEFEEEFEEEEG 940
Query: 340 LFRNMGRNEDGE 351
ED E
Sbjct: 941 ELEEEEEEEDEE 952
Score = 30.4 bits (67), Expect = 6.1
Identities = 18/62 (29%), Positives = 30/62 (48%), Gaps = 1/62 (1%)
Query: 262 ESHQHGSEEREEGSHEQDELHHRDTEEEEPF-ESSSEEEFGGEDHQSLNSIVDVEDLGKI 320
E + E+ EE +++E + EEEE F E EEE E+ + + E+L ++
Sbjct: 901 EEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEV 960
Query: 321 MD 322
D
Sbjct: 961 ED 962
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,640,171
Number of Sequences: 37866
Number of extensions: 1333310
Number of successful extensions: 7674
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 184
Number of HSP's that attempted gapping in prelim test: 5965
Number of HSP's gapped (non-prelim): 1096
length of query: 732
length of database: 18,247,518
effective HSP length: 110
effective length of query: 622
effective length of database: 14,082,258
effective search space: 8759164476
effective search space used: 8759164476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.