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Search of human proteins with 50658065
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1
[Homo sapiens]
(1288 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 ... 2514 0.0
gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 ... 2514 0.0
gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens] 360 4e-99
gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 ... 327 5e-89
gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens] 237 6e-62
gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens] 232 2e-60
gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens] 232 2e-60
gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens] 232 2e-60
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 117 7e-26
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 115 4e-25
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 111 4e-24
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 110 9e-24
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 108 3e-23
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 108 4e-23
gi|55770834 centromere protein F [Homo sapiens] 106 2e-22
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 105 2e-22
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 105 4e-22
gi|71061468 centromere protein E [Homo sapiens] 103 1e-21
gi|156104908 myosin heavy chain 6 [Homo sapiens] 103 1e-21
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 102 2e-21
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 101 4e-21
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 101 4e-21
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 101 4e-21
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 101 5e-21
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 101 5e-21
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 99 3e-20
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 94 6e-19
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 94 8e-19
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 94 1e-18
gi|118498368 kinectin 1 isoform c [Homo sapiens] 93 1e-18
>gi|50658065 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 2514 bits (6516), Expect = 0.0
Identities = 1288/1288 (100%), Positives = 1288/1288 (100%)
Query: 1 MPRKGTQPSTARRREEGPPPPSPDGASSDAEPEPPSGRTESPATAAETASEELDNRSLEE 60
MPRKGTQPSTARRREEGPPPPSPDGASSDAEPEPPSGRTESPATAAETASEELDNRSLEE
Sbjct: 1 MPRKGTQPSTARRREEGPPPPSPDGASSDAEPEPPSGRTESPATAAETASEELDNRSLEE 60
Query: 61 ILNSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKS 120
ILNSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKS
Sbjct: 61 ILNSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKS 120
Query: 121 NVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPN 180
NVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPN
Sbjct: 121 NVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPN 180
Query: 181 SNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKP 240
SNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKP
Sbjct: 181 SNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKP 240
Query: 241 KGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEG 300
KGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEG
Sbjct: 241 KGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEG 300
Query: 301 EKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSN 360
EKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSN
Sbjct: 301 EKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSN 360
Query: 361 EMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQK 420
EMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQK
Sbjct: 361 EMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQK 420
Query: 421 DKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKES 480
DKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKES
Sbjct: 421 DKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKES 480
Query: 481 REKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAA 540
REKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAA
Sbjct: 481 REKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAA 540
Query: 541 IRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVL 600
IRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVL
Sbjct: 541 IRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVL 600
Query: 601 DAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKR 660
DAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKR
Sbjct: 601 DAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKR 660
Query: 661 QNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADN 720
QNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADN
Sbjct: 661 QNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADN 720
Query: 721 LDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKME 780
LDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKME
Sbjct: 721 LDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKME 780
Query: 781 SQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVK 840
SQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVK
Sbjct: 781 SQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVK 840
Query: 841 ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLK 900
ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLK
Sbjct: 841 ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLK 900
Query: 901 AQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTA 960
AQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTA
Sbjct: 901 AQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTA 960
Query: 961 ELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQ 1020
ELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQ
Sbjct: 961 ELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQ 1020
Query: 1021 IDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLE 1080
IDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLE
Sbjct: 1021 IDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLE 1080
Query: 1081 ARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFY 1140
ARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFY
Sbjct: 1081 ARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFY 1140
Query: 1141 IITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSS 1200
IITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSS
Sbjct: 1141 IITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSS 1200
Query: 1201 LALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISD 1260
LALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISD
Sbjct: 1201 LALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISD 1260
Query: 1261 RLIGIYKTYNITKSVAVNPKEIASKGLC 1288
RLIGIYKTYNITKSVAVNPKEIASKGLC
Sbjct: 1261 RLIGIYKTYNITKSVAVNPKEIASKGLC 1288
>gi|50658063 SMC4 structural maintenance of chromosomes 4-like 1 [Homo
sapiens]
Length = 1288
Score = 2514 bits (6516), Expect = 0.0
Identities = 1288/1288 (100%), Positives = 1288/1288 (100%)
Query: 1 MPRKGTQPSTARRREEGPPPPSPDGASSDAEPEPPSGRTESPATAAETASEELDNRSLEE 60
MPRKGTQPSTARRREEGPPPPSPDGASSDAEPEPPSGRTESPATAAETASEELDNRSLEE
Sbjct: 1 MPRKGTQPSTARRREEGPPPPSPDGASSDAEPEPPSGRTESPATAAETASEELDNRSLEE 60
Query: 61 ILNSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKS 120
ILNSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKS
Sbjct: 61 ILNSIPPPPPPAMTNEAGAPRLMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKS 120
Query: 121 NVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPN 180
NVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPN
Sbjct: 121 NVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPN 180
Query: 181 SNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKP 240
SNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKP
Sbjct: 181 SNFYVSRTACRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKP 240
Query: 241 KGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEG 300
KGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEG
Sbjct: 241 KGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEG 300
Query: 301 EKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSN 360
EKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSN
Sbjct: 301 EKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSN 360
Query: 361 EMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQK 420
EMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQK
Sbjct: 361 EMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQK 420
Query: 421 DKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKES 480
DKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKES
Sbjct: 421 DKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKES 480
Query: 481 REKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAA 540
REKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAA
Sbjct: 481 REKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAA 540
Query: 541 IRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVL 600
IRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVL
Sbjct: 541 IRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVL 600
Query: 601 DAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKR 660
DAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKR
Sbjct: 601 DAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKR 660
Query: 661 QNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADN 720
QNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADN
Sbjct: 661 QNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADN 720
Query: 721 LDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKME 780
LDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKME
Sbjct: 721 LDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKME 780
Query: 781 SQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVK 840
SQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVK
Sbjct: 781 SQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVK 840
Query: 841 ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLK 900
ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLK
Sbjct: 841 ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLK 900
Query: 901 AQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTA 960
AQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTA
Sbjct: 901 AQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTA 960
Query: 961 ELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQ 1020
ELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQ
Sbjct: 961 ELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQ 1020
Query: 1021 IDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLE 1080
IDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLE
Sbjct: 1021 IDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLE 1080
Query: 1081 ARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFY 1140
ARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFY
Sbjct: 1081 ARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFY 1140
Query: 1141 IITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSS 1200
IITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSS
Sbjct: 1141 IITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSS 1200
Query: 1201 LALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISD 1260
LALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISD
Sbjct: 1201 LALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISD 1260
Query: 1261 RLIGIYKTYNITKSVAVNPKEIASKGLC 1288
RLIGIYKTYNITKSVAVNPKEIASKGLC
Sbjct: 1261 RLIGIYKTYNITKSVAVNPKEIASKGLC 1288
>gi|30581135 structural maintenance of chromosomes 1A [Homo sapiens]
Length = 1233
Score = 360 bits (925), Expect = 4e-99
Identities = 337/1300 (25%), Positives = 603/1300 (46%), Gaps = 191/1300 (14%)
Query: 90 QNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNS 149
+NFKSY G +I+GPF +RF+ IIGPNGSGKSN++D++ FV G + +R K L LIH +
Sbjct: 10 ENFKSYKGRQIIGPF-QRFTAIIGPNGSGKSNLMDAISFVLGEKTSNLRVKTLRDLIHGA 68
Query: 150 DEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACR---DNTSVYHISGKKKTF 206
K + + +EG + RT R +S Y I+ K
Sbjct: 69 PVGKPAAN---RAFVSMVYSEEGAE-----------DRTFARVIVGGSSEYKINNKVVQL 114
Query: 207 KDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEP 266
+ L GI + FL+ QG VE IAM PK +T E+I G L +
Sbjct: 115 HEYSEELEKLGILIKARNFLVFQGAVESIAMKNPKERTA-------LFEEISRSGELAQE 167
Query: 267 IKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYY 326
+ + E +R K + E+ + EK A + L++E+ R
Sbjct: 168 YDKRKKEMVKAEEDTQFNYHRKKNIAAERKEAKQEKEEADRYQRLKDEVVR--------- 218
Query: 327 IYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEEN 386
A+++ Q K++ + EI + L+ E+ +KNK+++ +K+++K+ ++E
Sbjct: 219 --------AQVQLQLFKLYHNEVEIEK----LNKELASKNKEIEKDKKRMDKVEDELKEK 266
Query: 387 KEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKE----KVEEFKSIPAKSNNIINET 442
K++ ++ E Q+ +++K S+ + Q K KE K+++ ++ N
Sbjct: 267 KKELGKMMREQQQIEKEIKEKDSELNQKRPQYIKAKENTSHKIKKLEAAKKSLQNAQKHY 326
Query: 443 TTRN---NALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKM 499
R + LEKE EK +E + +++E+Q ++ E ++ + + EA +
Sbjct: 327 KKRKGDMDELEKEMLSVEKARQEFEERMEEESQSQGRDLTLEENQVKKYHRLKEEASKRA 386
Query: 500 DVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKE 559
EL+ + +L L+ERK + E K+ Q +E++E +
Sbjct: 387 ATLAQELEKFNRDQKADQDRLD------------LEERKKV--ETEAKIKQKLREIEENQ 432
Query: 560 KELQKLTQEETNFKS-------LVHDLFQKVEEAKSSL-AMNRSRGKVL----DAIIQEK 607
K ++KL + T K L +L ++VE AK + +N+ +V+ DA I +
Sbjct: 433 KRIEKLEEYITTSKQSLEEQKKLEGELTEEVEMAKRRIDEINKELNQVMEQLGDARIDRQ 492
Query: 608 KSGR--------------IPG-IYGRLGDL-GAIDEKYDVAISSCCHA-LDYIVVDSIDI 650
+S R PG +YGRL DL +KY +A++ +D I+VDS
Sbjct: 493 ESSRQQRKAEIMESIKRLYPGSVYGRLIDLCQPTQKKYQIAVTKVLGKNMDAIIVDSEKT 552
Query: 651 AQECVNFLKRQNIGVATFIGLDKMAVWA--KKMTEIQTPENTPRLFDLVKVKDEKIRQAF 708
++C+ ++K Q TF+ LD + V +K+ E++ + D+++ + I++A
Sbjct: 553 GRDCIQYIKEQRGEPETFLPLDYLEVKPTDEKLRELK---GAKLVIDVIRYEPPHIKKAL 609
Query: 709 YFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVM-KGRMGSSL 767
+A + LV DN++ A R+A+ +R + V L G + ++SG ++GG S + K R
Sbjct: 610 QYACGNALVCDNVEDARRIAFGGHQRHKTVALDGTLFQKSGVISGGASDLKAKARRWDEK 669
Query: 768 VIEISEEEVNKMESQLQNDSK---KAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTAS 824
++ +E+ ++ +L+ K K ++++ + Q ++L++S+ ++ T + A
Sbjct: 670 AVDKLKEKKERLTEELKEQMKAKRKEAELRQVQSQAHGLQMRLKYSQSDLEQTKTRHLA- 728
Query: 825 IQRLIEQEEYLNVQVK-ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAE 883
LN+Q K +LE+ + P K + + + + E + EK +VE E
Sbjct: 729 ----------LNLQEKSKLESELANFGPRINDIKRI---IQSREREMKDLKEKMNQVEDE 775
Query: 884 VKRLH------NTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKA 937
V I E K+K Q + I K+ E + T+ + + L++
Sbjct: 776 VFEEFCREIGVRNIREFEEEKVKRQNE----IAKKRLEFENQKTRLGIQLDFEKNQLKED 831
Query: 938 QDSVLRTEKEIKDTEKEVDDLTAE----LKSLEDKAAEV--VKNTNAAEES-LPEIQKEH 990
QD V E+ +K E E++ L E +K +++ A++ +KN + A++S + + E
Sbjct: 832 QDKVHMWEQTVKKDENEIEKLKKEEQRHMKIIDETMAQLQDLKNQHLAKKSEVNDKNHEM 891
Query: 991 RNLLQELKVIQENEHALQKDALSIKLKLEQ--IDGHIAEHNSKIKYWHKEISKISLHPIE 1048
+ ++L + LQK+ +I+ KLEQ D H K++ +SK ++ I
Sbjct: 892 EEIRKKLGGANKEMTHLQKEVTAIETKLEQKRSDRHNLLQACKMQDIKLPLSKGTMDDIS 951
Query: 1049 DNPIEEISVLSPEDLEAIKNPDSITNQIALLEARC-------------HEMKPNLGAIAE 1095
EE S + + + SI + AL+E E+K + + +
Sbjct: 952 Q---EEGSSQGEDSVSGSQRISSIYAREALIEIDYGDLCEDLKDAQAEEEIKQEMNTLQQ 1008
Query: 1096 YKKKEELYLQRVAE-----LDKITYERDSF-----------------RQAYEDLRKQRLN 1133
+++ LQR+A ++K+ RD F +QA+E ++K+R +
Sbjct: 1009 KLNEQQSVLQRIAAPNMKAMEKLESVRDKFQETSDEFEAARKRAKKAKQAFEQIKKERFD 1068
Query: 1134 EFMAGFYIITNKLKENYQMLTLGGDAELEL--VDSLDPFSEGIMFSVRPPKKSWKKIFNL 1191
F A F + + E Y+ L+ A+ L + +P+ +GI ++ P K ++ + NL
Sbjct: 1069 RFNACFESVATNIDEIYKALSRNSSAQAFLGPENPEEPYLDGINYNCVAPGKRFRPMDNL 1128
Query: 1192 SGGEKTLSSLALVFALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQ-TKNAQFIIIS 1250
SGGEKT+++LAL+FA+H YKP P + +DEIDAALD N+ VA YI EQ T N Q I+IS
Sbjct: 1129 SGGEKTVAALALLFAIHSYKPAPFFVLDEIDAALDNTNIGKVANYIKEQSTCNFQAIVIS 1188
Query: 1251 LRNNMFEISDRLIGIYK-----------TYNITKSVAVNP 1279
L+ + ++ LIG+Y T+++TK NP
Sbjct: 1189 LKEEFYTKAESLIGVYPEQGDCVISKVLTFDLTKYPDANP 1228
>gi|71565160 SMC1 structural maintenance of chromosomes 1-like 2 [Homo
sapiens]
Length = 1235
Score = 327 bits (838), Expect = 5e-89
Identities = 302/1247 (24%), Positives = 574/1247 (46%), Gaps = 118/1247 (9%)
Query: 90 QNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNS 149
+NFKS+ G +++GPF +RF+CIIGPNGSGKSNV+D++ FV G + +R K + LIH +
Sbjct: 10 ENFKSWRGRQVIGPF-RRFTCIIGPNGSGKSNVMDALSFVMGEKIANLRVKNIQELIHGA 68
Query: 150 DEHKDIQS-CTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNT---SVYHISGKKKT 205
K I S +V++ + +++ G++ S DN SVY
Sbjct: 69 HIGKPISSSASVKIIY---VEESGEEKTFARIIRGGCSEFRFNDNLVSRSVYIAE----- 120
Query: 206 FKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNE 265
L GI + L+ QG VE I++ KPK +T+ + E+I G L
Sbjct: 121 -------LEKIGIIVKAQNCLVFQGTVESISVKKPKERTQ-------FFEEISTSGELIG 166
Query: 266 PIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQY 325
+ R+++ E N+ K + E+ + EK A + +L E+ K + +
Sbjct: 167 EYEEKKRKLQKAEEDAQFNFNKKKNIAAERRQAKLEKEEAERYQSLLEELKMNKIQLQLF 226
Query: 326 YIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKD-------VKDTEKKLNK 378
+Y +K+I + T+ E ++ D E + N +KA+ K+ ++ TEK+L
Sbjct: 227 QLYHNEKKIHLLNTKLEHVNRDLSVKRESLSHHENIVKARKKEHGMLTRQLQQTEKELKS 286
Query: 379 ITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNI 438
+ + + + ++ + +KL A K EKQ K ++ ++ ++ A
Sbjct: 287 VETLLNQKRPQYIKAKENTSHHLKKLDVAKKSIKDSEKQCSKQEDDIKALETELA----- 341
Query: 439 INETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSK 498
+ + EK+ E+E K ++ + ++ KE K++ ++ + + + +
Sbjct: 342 --DLDAAWRSFEKQIEEEILHKKRDIELEASQLDRYKELKEQVRKKVATMTQQLEKLQWE 399
Query: 499 MDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEK 558
+ L RH L + KE + ++ K I +E LKEK
Sbjct: 400 QKTDEERLAFEKRRHGEVQGNLKQIKEQI-------EDHKKRIEKLEEYTKTCMDCLKEK 452
Query: 559 EKELQKLTQEETNFKSLVHDLFQKVEEAKSSL---AMNRSRGKVLDA---IIQEKKSGRI 612
+++ + L E KS + + +++ +S L ++ GK +++ K
Sbjct: 453 KQQEETLVDEIEKTKSRMSEFNEELNLIRSELQNAGIDTHEGKRQQKRAEVLEHLKRLYP 512
Query: 613 PGIYGRLGDL-GAIDEKYDVAISSCC-HALDYIVVDSIDIAQECVNFLKRQNIGVATFIG 670
++GRL DL I +KY +A++ + IVV S +A++C+ FLK + TF+
Sbjct: 513 DSVFGRLFDLCHPIHKKYQLAVTKVFGRFITAIVVASEKVAKDCIRFLKEERAEPETFLA 572
Query: 671 LDKMAVWAKKMTE-IQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAY 729
LD + + K + E ++ + + D++K + ++++ F + LV + +++A +A
Sbjct: 573 LDYLDI--KPINERLRELKGCKMVIDVIKTQFPQLKKVIQFVCGNGLVCETMEEARHIAL 630
Query: 730 QKDRRWRVVTLQGQIIEQSGTMTGGGSKVM-KGRMGSSLVIEISEEEVNKMESQLQNDSK 788
R + V L G + +SG ++GG S + K R ++ + ++ +L+ K
Sbjct: 631 SGPERQKTVALDGTLFLKSGVISGGSSDLKYKARCWDEKELKNLRDRRSQKIQELKGLMK 690
Query: 789 ---KAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASI--QRLIEQEEYLNVQVKELE 843
K +++ + ++ +L++S+ E+ +K + ++ Q E LN+ E +
Sbjct: 691 TLRKETDLKQIQTLIQGTQTRLKYSQNELEMIKKKHLVAFYQEQSQLQSELLNI---ESQ 747
Query: 844 ANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAE-VKRLHNTIV----EINNHK 898
+L+ ++++++ E K E D ++ E ++ N V EI+ +
Sbjct: 748 CIMLSEGIKERQRRIKEFQEKIDKVEDDIFQHFCEEIGVENIREFENKHVKRQQEIDQKR 807
Query: 899 LKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDL 958
L+ ++ K ++N QL+ S + K I T +QK + + +K ++ + V++L
Sbjct: 808 LEFEKQKT-RLNVQLEYSRSHLKKKLNKINTLKETIQKGSEDIDHLKKAEENCLQTVNEL 866
Query: 959 TAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKL 1018
A+ + L+D V ++AE+ +I++E + L + LQK+ +SI+ L
Sbjct: 867 MAKQQQLKDIR---VTQNSSAEKVQTQIEEERKKFL----AVDREVGKLQKEVVSIQTSL 919
Query: 1019 EQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIE-----------------------EI 1055
EQ + +HN + ++I I L D+ IE EI
Sbjct: 920 EQ--KRLEKHNLLLDCKVQDIEIILLSGSLDDIIEVEMGTEAESTQATIDIYEKEEAFEI 977
Query: 1056 SVLS-PEDLEAIKNPDSITNQIALLEARCHEMK--------PNLGAIAEYKKKEELYLQR 1106
S EDL+A+++ I + LL + + PNL A+ K + + +
Sbjct: 978 DYSSLKEDLKALQSDQEIEAHLRLLLQQVASQEDILLKTAAPNLRALENLKTVRDKFQES 1037
Query: 1107 VAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAE--LELV 1164
+ E RQ +E ++K+R + F F ++ + + Y+ L A+ L
Sbjct: 1038 TDAFEASRKEARLCRQEFEQVKKRRYDLFTQCFEHVSISIDQIYKKLCRNNSAQAFLSPE 1097
Query: 1165 DSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLYFMDEIDAA 1224
+ +P+ EGI ++ P K + + NLSGGEK +++LAL+FA+H ++P P + +DE+DAA
Sbjct: 1098 NPEEPYLEGISYNCVAPGKRFMPMDNLSGGEKCVAALALLFAVHSFRPAPFFVLDEVDAA 1157
Query: 1225 LDFKNVSIVAFYIYEQTKNA-QFIIISLRNNMFEISDRLIGIYKTYN 1270
LD N+ V+ YI EQT++ Q I+ISL+ + +D LIGIY Y+
Sbjct: 1158 LDNTNIGKVSSYIKEQTQDQFQMIVISLKEEFYSRADALIGIYPEYD 1204
>gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]
Length = 1217
Score = 237 bits (604), Expect = 6e-62
Identities = 276/1278 (21%), Positives = 563/1278 (44%), Gaps = 148/1278 (11%)
Query: 82 LMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKK 141
+ I ++ Q F+SY + I+ PF + + I+G NGSGKSN ++ FV +R ++
Sbjct: 1 MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQ 60
Query: 142 LSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRDNTSVYHISG 201
L+H + I S VE+ F ++ D E + R Y +
Sbjct: 61 RLALLHEGTGPRVI-SAFVEIIFDNSDNRLPIDKEEVS------LRRVIGAKKDQYFLDK 113
Query: 202 KKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCG 261
K T DV NLL S G + +++ QG++ Q+A T D L+ L ++ G
Sbjct: 114 KMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMA-------TAPDSQRLKLLREVAGTR 166
Query: 262 RLNEPIKVLCRRVEILNEHRG--EKLNRV-KMVEKEKDALEGEKNIAIEFLTLENEIFRK 318
+E + + ++ E G EK+N + K +E+ LE EK ++ + + K
Sbjct: 167 VYDERKE---ESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQY-----QKWDK 218
Query: 319 KNHVCQYYIY-----ELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTE 373
+Y IY E + ++ E+ ++E E ++++ + ++M+ + V++ +
Sbjct: 219 MRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELK 278
Query: 374 KKLNKITKFIE-------ENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVE 426
K++ + + E E ++ T+L+L+ ++++L + + K+L K+ QK EK+E
Sbjct: 279 TKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIE 338
Query: 427 EFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKE--------K 478
E + ET + N++ KEKEE+ + + + ++ T K+ K
Sbjct: 339 E-------KQKELAETEPKFNSV---KEKEERGIARLAQATQERTDLYAKQGRGSQFTSK 388
Query: 479 ESREK----ELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETL 534
E R+K EL +++N+ + ++ +L+ + + Q K + L
Sbjct: 389 EERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKL-------DQDL 441
Query: 535 KERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSL--AM 592
E KA + +++ K + + + E + E L +EE + + + +E+ + L A
Sbjct: 442 NEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAAT 501
Query: 593 NRSRGKVLDAIIQEKKSGRIPGIYGRL--GDLGAIDEKYDV--AISSCCHA-----LDYI 643
++ +D+I + R GI + G G + ++ A +C L Y
Sbjct: 502 GKAILNGIDSINKVLDHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYH 561
Query: 644 VVDSIDIAQECVNFLKRQNI-GVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVK-D 701
+VDS +++ + + + N+ G TF+ L+K+ V + PE + + K++ +
Sbjct: 562 IVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDV-----RDTAYPETNDAIPMISKLRYN 616
Query: 702 EKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKG 761
+ +AF TL+ +++ +T++A + +TL+G + G +TGG K
Sbjct: 617 PRFDKAFKHVFGKTLICRSMEVSTQLA--RAFTMDCITLEGDQVSHRGALTGGYYDTRKS 674
Query: 762 RMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKF 821
R+ + +EEE+ ++E++L + ++ ++ ++ + +L + +++ KF
Sbjct: 675 RLELQKDVRKAEEELGELEAKLNENLRRNIE------RINNEIDQLMNQMQQIETQQRKF 728
Query: 822 TASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVE 881
AS ++ + + L + ++ E + P ++ + LE ++ A ++ +++ + G
Sbjct: 729 KASRDSILSEMKMLKEKRQQSEKTFM---PKQRSLQSLEASLHAMESTRESLKAELGTDL 785
Query: 882 AEVKRLHNT--IVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQD 939
L + + +N+ + QQ+ +N+++ + IT+ + + + NL+K D
Sbjct: 786 LSQLSLEDQKRVDALNDEIRQLQQENRQLLNERI-KLEGIITRVETYL---NENLRKRLD 841
Query: 940 SVLRTEKEIKDTE--KEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQEL 997
V + E+++TE + T+EL+++ + VK+T A E L + ++EL
Sbjct: 842 QVEQELNELRETEGGTVLTATTSELEAINKR----VKDTMARSEDLDNSIDKTEAGIKEL 897
Query: 998 KVIQENEHALQKDAL-SIKLKLEQIDGHIAEHNSKIKYWHKEISKI-SLHPIEDNPIEEI 1055
+ E ++K+ + +I ++++ +K + + KI L + E+
Sbjct: 898 QKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKY 957
Query: 1056 SVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITY 1115
LS + L + + + L+ H K L + +++E ++R ELD+
Sbjct: 958 QTLSLKQL--FRKLEQCNTE---LKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDR--- 1009
Query: 1116 ERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELEL------------ 1163
S + L ++ F ++ E +Q L GG A L +
Sbjct: 1010 GYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQD 1069
Query: 1164 -----------------VDSLDPFSE-GIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVF 1205
V S+D F+ GI S + +++ LSGG+K+L +LAL+F
Sbjct: 1070 EGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIF 1129
Query: 1206 ALHHYKPTPLYFMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGI 1265
A+ P P Y DEID ALD ++ V+ I E +AQFI + R + E +D+ G+
Sbjct: 1130 AIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGV 1189
Query: 1266 YKTYNITKSVAVNPKEIA 1283
K N + V E+A
Sbjct: 1190 -KFRNKVSHIDVITAEMA 1206
>gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 232 bits (592), Expect = 2e-60
Identities = 288/1240 (23%), Positives = 536/1240 (43%), Gaps = 159/1240 (12%)
Query: 84 ITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGY-RAQKIRSKKL 142
I I+ + FKSYA + F F+ I G NGSGKSN++DS+ F+ G ++R+ L
Sbjct: 3 IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
Query: 143 SVLIHNSDEHKDIQSCTVEVHFQKIIDKEGD-DYEVIPNSNFYVSRTACRDNTSVYHISG 201
L++ + + I +V + F K+ +EV + V+R + Y I+G
Sbjct: 63 QDLVYKNGQ-AGITKASVSITFDNSDKKQSPLGFEV--HDEITVTRQVVIGGRNKYLING 119
Query: 202 KKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCG 261
V +L S G+++++ FLI+QG + ++ MKP +L +E+ G
Sbjct: 120 VNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPE-------ILSMIEEAAGT- 171
Query: 262 RLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEK-----DALEGEKNIAIEFLTLENEIF 316
R+ E K+ ++ E + KL +K + +E+ L+ E++ +E+ ++
Sbjct: 172 RMYEYKKIAAQKTI---EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEY----QKVM 224
Query: 317 RKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKL 376
R+ H+ + YI + E K + E+ KE+ +K L E+ +K +K L
Sbjct: 225 REIEHLSRLYI---AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIK----AL 277
Query: 377 NKITKFIEENKEKFTQ---LDLEDV-----QVREKLKHATSKAKK---LEKQLQKDKEK- 424
N + +E+ K+K T LED +V K + A KK E+ +K+ EK
Sbjct: 278 NHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKN 337
Query: 425 -VEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREK 483
VE+ K++ AK + + T +AL++ K+ + L + GL ++ E
Sbjct: 338 MVEDSKTLAAKEKEV-KKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEA 396
Query: 484 ELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRD 543
L G + SK A ++ +A+ L A + LK ++A ++
Sbjct: 397 TLAGQMMACKNDISK-----------------AQTEAKQAQMKLKHAQQELKNKQAEVKK 439
Query: 544 IEGKLPQTEQ------ELKEK-EKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSR 596
++ + ++ LKEK E E++KL EE +SL+ Q ++R
Sbjct: 440 MDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQ----------LSRDI 489
Query: 597 GKVLDAIIQEKKSGRIPGI----------YGRLGDLGAIDEKYDVAISSCCHALDYIVVD 646
G++ + E R P + + R G + V +S AL+ + +
Sbjct: 490 GRLKETY--EALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGE 547
Query: 647 S-----IDIAQECVNFLKRQNIGVA-TFIGLDKMAVWA------KKMTEIQTPENTPRLF 694
+D L+R + T I L+K++ + + P+N
Sbjct: 548 RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607
Query: 695 DLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGG 754
LV+ K E +++A F T V DN+D A +VA+ K R VTL G + + GT++GG
Sbjct: 608 SLVEYKPE-LQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGG 666
Query: 755 GSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREM 814
+S++ + +E+ ++ +L+ + ++E+ L+ K R +++
Sbjct: 667 ARS-----QAASILTKF--QELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQW 719
Query: 815 RNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA 874
E+ +Q ++Q Y + Q +EL+A ++ K +E + +Y+ +
Sbjct: 720 EMKTEEADL-LQTKLQQSSY-HKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLE 777
Query: 875 EKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNL 934
K EAE +R +LK Q KLD CA TKA + K
Sbjct: 778 NKMKNAEAERER-----------ELKDAQKKLD--------CAK--TKADASSKKMKEKQ 816
Query: 935 QKAQDSVLRTE---KEIKDTEKEVDDLTAELKSLEDK----AAEVVKNTNAAEESLPEIQ 987
Q+ + L E +E +++++ + +KS E + AAEV KN + ++ E+
Sbjct: 817 QEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVT 876
Query: 988 KEHRNLLQELKVIQEN--EHALQKDALS-IKLKLEQIDGHIAEHNSKIKYWHKEISKISL 1044
K+ + + VI+ E A K+ + +LK++++D +I++H + + ++SK+ L
Sbjct: 877 KQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKM-L 935
Query: 1045 HPIEDNPIEEISVLSPEDLEAIK--NPDSITNQIALLEARCHEMKPNLG------AIAEY 1096
+ E P K NP ++ L+ EMK LG A+
Sbjct: 936 KDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQ----EMKEKLGRNVNMRAMNVL 991
Query: 1097 KKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLG 1156
+ EE Y + + + ++ EDL +++ + + + L G
Sbjct: 992 TEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPG 1051
Query: 1157 GDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLY 1216
+A L + +G+ F V + + LSGG+++L +L+L+ ++ +KP P+Y
Sbjct: 1052 ANAMLAPPEG-QTVLDGLEFKVALGNTWKENLTELSGGQRSLVALSLILSMLLFKPAPIY 1110
Query: 1217 FMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMF 1256
+DE+DAALD + + + ++QFI++SL+ MF
Sbjct: 1111 ILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMF 1150
>gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 232 bits (592), Expect = 2e-60
Identities = 288/1240 (23%), Positives = 536/1240 (43%), Gaps = 159/1240 (12%)
Query: 84 ITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGY-RAQKIRSKKL 142
I I+ + FKSYA + F F+ I G NGSGKSN++DS+ F+ G ++R+ L
Sbjct: 3 IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
Query: 143 SVLIHNSDEHKDIQSCTVEVHFQKIIDKEGD-DYEVIPNSNFYVSRTACRDNTSVYHISG 201
L++ + + I +V + F K+ +EV + V+R + Y I+G
Sbjct: 63 QDLVYKNGQ-AGITKASVSITFDNSDKKQSPLGFEV--HDEITVTRQVVIGGRNKYLING 119
Query: 202 KKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCG 261
V +L S G+++++ FLI+QG + ++ MKP +L +E+ G
Sbjct: 120 VNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPE-------ILSMIEEAAGT- 171
Query: 262 RLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEK-----DALEGEKNIAIEFLTLENEIF 316
R+ E K+ ++ E + KL +K + +E+ L+ E++ +E+ ++
Sbjct: 172 RMYEYKKIAAQKTI---EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEY----QKVM 224
Query: 317 RKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKL 376
R+ H+ + YI + E K + E+ KE+ +K L E+ +K +K L
Sbjct: 225 REIEHLSRLYI---AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIK----AL 277
Query: 377 NKITKFIEENKEKFTQ---LDLEDV-----QVREKLKHATSKAKK---LEKQLQKDKEK- 424
N + +E+ K+K T LED +V K + A KK E+ +K+ EK
Sbjct: 278 NHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKN 337
Query: 425 -VEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREK 483
VE+ K++ AK + + T +AL++ K+ + L + GL ++ E
Sbjct: 338 MVEDSKTLAAKEKEV-KKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEA 396
Query: 484 ELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRD 543
L G + SK A ++ +A+ L A + LK ++A ++
Sbjct: 397 TLAGQMMACKNDISK-----------------AQTEAKQAQMKLKHAQQELKNKQAEVKK 439
Query: 544 IEGKLPQTEQ------ELKEK-EKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSR 596
++ + ++ LKEK E E++KL EE +SL+ Q ++R
Sbjct: 440 MDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQ----------LSRDI 489
Query: 597 GKVLDAIIQEKKSGRIPGI----------YGRLGDLGAIDEKYDVAISSCCHALDYIVVD 646
G++ + E R P + + R G + V +S AL+ + +
Sbjct: 490 GRLKETY--EALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGE 547
Query: 647 S-----IDIAQECVNFLKRQNIGVA-TFIGLDKMAVWA------KKMTEIQTPENTPRLF 694
+D L+R + T I L+K++ + + P+N
Sbjct: 548 RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607
Query: 695 DLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGG 754
LV+ K E +++A F T V DN+D A +VA+ K R VTL G + + GT++GG
Sbjct: 608 SLVEYKPE-LQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGG 666
Query: 755 GSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREM 814
+S++ + +E+ ++ +L+ + ++E+ L+ K R +++
Sbjct: 667 ARS-----QAASILTKF--QELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQW 719
Query: 815 RNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA 874
E+ +Q ++Q Y + Q +EL+A ++ K +E + +Y+ +
Sbjct: 720 EMKTEEADL-LQTKLQQSSY-HKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLE 777
Query: 875 EKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNL 934
K EAE +R +LK Q KLD CA TKA + K
Sbjct: 778 NKMKNAEAERER-----------ELKDAQKKLD--------CAK--TKADASSKKMKEKQ 816
Query: 935 QKAQDSVLRTE---KEIKDTEKEVDDLTAELKSLEDK----AAEVVKNTNAAEESLPEIQ 987
Q+ + L E +E +++++ + +KS E + AAEV KN + ++ E+
Sbjct: 817 QEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVT 876
Query: 988 KEHRNLLQELKVIQEN--EHALQKDALS-IKLKLEQIDGHIAEHNSKIKYWHKEISKISL 1044
K+ + + VI+ E A K+ + +LK++++D +I++H + + ++SK+ L
Sbjct: 877 KQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKM-L 935
Query: 1045 HPIEDNPIEEISVLSPEDLEAIK--NPDSITNQIALLEARCHEMKPNLG------AIAEY 1096
+ E P K NP ++ L+ EMK LG A+
Sbjct: 936 KDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQ----EMKEKLGRNVNMRAMNVL 991
Query: 1097 KKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLG 1156
+ EE Y + + + ++ EDL +++ + + + L G
Sbjct: 992 TEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPG 1051
Query: 1157 GDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLY 1216
+A L + +G+ F V + + LSGG+++L +L+L+ ++ +KP P+Y
Sbjct: 1052 ANAMLAPPEG-QTVLDGLEFKVALGNTWKENLTELSGGQRSLVALSLILSMLLFKPAPIY 1110
Query: 1217 FMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMF 1256
+DE+DAALD + + + ++QFI++SL+ MF
Sbjct: 1111 ILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMF 1150
>gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 232 bits (592), Expect = 2e-60
Identities = 288/1240 (23%), Positives = 536/1240 (43%), Gaps = 159/1240 (12%)
Query: 84 ITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGY-RAQKIRSKKL 142
I I+ + FKSYA + F F+ I G NGSGKSN++DS+ F+ G ++R+ L
Sbjct: 3 IKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNL 62
Query: 143 SVLIHNSDEHKDIQSCTVEVHFQKIIDKEGD-DYEVIPNSNFYVSRTACRDNTSVYHISG 201
L++ + + I +V + F K+ +EV + V+R + Y I+G
Sbjct: 63 QDLVYKNGQ-AGITKASVSITFDNSDKKQSPLGFEV--HDEITVTRQVVIGGRNKYLING 119
Query: 202 KKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCG 261
V +L S G+++++ FLI+QG + ++ MKP +L +E+ G
Sbjct: 120 VNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPE-------ILSMIEEAAGT- 171
Query: 262 RLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEK-----DALEGEKNIAIEFLTLENEIF 316
R+ E K+ ++ E + KL +K + +E+ L+ E++ +E+ ++
Sbjct: 172 RMYEYKKIAAQKTI---EKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEY----QKVM 224
Query: 317 RKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKL 376
R+ H+ + YI + E K + E+ KE+ +K L E+ +K +K L
Sbjct: 225 REIEHLSRLYI---AYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIK----AL 277
Query: 377 NKITKFIEENKEKFTQ---LDLEDV-----QVREKLKHATSKAKK---LEKQLQKDKEK- 424
N + +E+ K+K T LED +V K + A KK E+ +K+ EK
Sbjct: 278 NHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKN 337
Query: 425 -VEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREK 483
VE+ K++ AK + + T +AL++ K+ + L + GL ++ E
Sbjct: 338 MVEDSKTLAAKEKEV-KKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEA 396
Query: 484 ELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRD 543
L G + SK A ++ +A+ L A + LK ++A ++
Sbjct: 397 TLAGQMMACKNDISK-----------------AQTEAKQAQMKLKHAQQELKNKQAEVKK 439
Query: 544 IEGKLPQTEQ------ELKEK-EKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSR 596
++ + ++ LKEK E E++KL EE +SL+ Q ++R
Sbjct: 440 MDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQ----------LSRDI 489
Query: 597 GKVLDAIIQEKKSGRIPGI----------YGRLGDLGAIDEKYDVAISSCCHALDYIVVD 646
G++ + E R P + + R G + V +S AL+ + +
Sbjct: 490 GRLKETY--EALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGE 547
Query: 647 S-----IDIAQECVNFLKRQNIGVA-TFIGLDKMAVWA------KKMTEIQTPENTPRLF 694
+D L+R + T I L+K++ + + P+N
Sbjct: 548 RLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVAL 607
Query: 695 DLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGG 754
LV+ K E +++A F T V DN+D A +VA+ K R VTL G + + GT++GG
Sbjct: 608 SLVEYKPE-LQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGG 666
Query: 755 GSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREM 814
+S++ + +E+ ++ +L+ + ++E+ L+ K R +++
Sbjct: 667 ARS-----QAASILTKF--QELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQW 719
Query: 815 RNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA 874
E+ +Q ++Q Y + Q +EL+A ++ K +E + +Y+ +
Sbjct: 720 EMKTEEADL-LQTKLQQSSY-HKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLE 777
Query: 875 EKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNL 934
K EAE +R +LK Q KLD CA TKA + K
Sbjct: 778 NKMKNAEAERER-----------ELKDAQKKLD--------CAK--TKADASSKKMKEKQ 816
Query: 935 QKAQDSVLRTE---KEIKDTEKEVDDLTAELKSLEDK----AAEVVKNTNAAEESLPEIQ 987
Q+ + L E +E +++++ + +KS E + AAEV KN + ++ E+
Sbjct: 817 QEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVT 876
Query: 988 KEHRNLLQELKVIQEN--EHALQKDALS-IKLKLEQIDGHIAEHNSKIKYWHKEISKISL 1044
K+ + + VI+ E A K+ + +LK++++D +I++H + + ++SK+ L
Sbjct: 877 KQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKM-L 935
Query: 1045 HPIEDNPIEEISVLSPEDLEAIK--NPDSITNQIALLEARCHEMKPNLG------AIAEY 1096
+ E P K NP ++ L+ EMK LG A+
Sbjct: 936 KDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQ----EMKEKLGRNVNMRAMNVL 991
Query: 1097 KKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLG 1156
+ EE Y + + + ++ EDL +++ + + + L G
Sbjct: 992 TEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPG 1051
Query: 1157 GDAELELVDSLDPFSEGIMFSVRPPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLY 1216
+A L + +G+ F V + + LSGG+++L +L+L+ ++ +KP P+Y
Sbjct: 1052 ANAMLAPPEG-QTVLDGLEFKVALGNTWKENLTELSGGQRSLVALSLILSMLLFKPAPIY 1110
Query: 1217 FMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMF 1256
+DE+DAALD + + + ++QFI++SL+ MF
Sbjct: 1111 ILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMF 1150
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 117 bits (293), Expect = 7e-26
Identities = 162/851 (19%), Positives = 361/851 (42%), Gaps = 137/851 (16%)
Query: 286 NRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHV--CQYYIYELQKRIAEMETQKEK 343
N K+++ EK+ K + I LENEI ++K + CQ +L K A++E E
Sbjct: 489 NASKILKMEKENQRLSKKVEI----LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 344 IHEDTK-------EINEKSNILSNEMKAKNK-----DVKDTEKKLNKITKFIEENKEKFT 391
+ E+++ + NE N + ++ +++ VKD EK+ + + I+E K +
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 392 QLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEK 451
+++ E Q++++L+H K ++ E +L+ + +E+ + K + T + ALE+
Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAE-ELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
Query: 452 EK---EKEEKKLKEVMDSLKQET---QGLQKEKESREKELMGFSKSVNEAR--------- 496
E E+E +KLK+ +DS K T + L+KE ++E + ++V +
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 497 ----------------------------SKMDVAQSELDIY-------LSRHNTAVSQLT 521
+++V+ LDI L N + QL
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 522 KAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQ 581
+ L ++TL++ ++ +L Q E+E K E+E +L +++ +
Sbjct: 784 SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK-----------K 832
Query: 582 KVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALD 641
++E+ L R + ++ D ++E ++G+L EK + +S
Sbjct: 833 QLEKENKRL---RQQAEIKDTTLEENNV--------KIGNL----EKENKTLSKEIGIYK 877
Query: 642 YIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKV-- 699
V ++ +E +KR I + T + L + V K T+ + +L K+
Sbjct: 878 ESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGL 937
Query: 700 ------KDEKIRQAFYFALRDTLVADNLDQATRVAYQK----DRRWRVVTLQGQIIEQSG 749
DE+ + L ++ + L ++ + +K + R T Q + Q
Sbjct: 938 NKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 997
Query: 750 TMTGGGSKVMKGRMGSSLVIEIS---EEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVK 806
+ +K R +++ S E NK E + Q +++ ++++++ +++E
Sbjct: 998 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1057
Query: 807 LRHSEREMR----------NTLEKFTASIQR--LIEQEEYLNVQVKELEANVLATAPDKK 854
L+ ++ ++ N L+ ++QR + QE+ +Q + + V + + +
Sbjct: 1058 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1117
Query: 855 KQKLLEENVSAF--KTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQ 912
L+ +N ++ + E K ++K L++++++ ++ KL+ ++ +
Sbjct: 1118 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK-DHEKLELLHERQASEYES 1176
Query: 913 LDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEK----EVDDLTAELKSLEDK 968
L + A ++ R+L+ + +L+ + +++D EK E + + E K+ E
Sbjct: 1177 LISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETV 1236
Query: 969 AAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEH 1028
AAE K + + + LL+E +V+Q + L+ + KL+ +++
Sbjct: 1237 AAEYKKLCGEND----RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEF--- 1289
Query: 1029 NSKIKYWHKEI 1039
SK+K ++++
Sbjct: 1290 -SKLKEQYQQL 1299
Score = 102 bits (253), Expect = 3e-21
Identities = 193/967 (19%), Positives = 414/967 (42%), Gaps = 135/967 (13%)
Query: 252 EYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTL 311
E E ++ C + E +++ +R++ N + +M E DAL EK + ++ L
Sbjct: 269 EKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR-EKAVRVDKLES 327
Query: 312 ENEIFRKKNHVCQYY---IYELQK--------------RIAEMETQKEKIHEDTKEINEK 354
E ++++ H ++Y + EL++ ++ + +K+HE EK
Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHE-----LEK 382
Query: 355 SNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKL 414
N+ ++KAK + D E + + K IEE E+ L++ Q ++ H + +++
Sbjct: 383 ENL---QLKAK---LHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQI 436
Query: 415 EKQLQKDKEKVEEFKSIPAKS-NNIINE-TTTRNNALEKEKE---KEEKKLKEVMDS--- 466
+ E P KS + +NE T++R LE E + K ++L+ +DS
Sbjct: 437 --------SRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 467 -------LKQETQGLQKEKESREKELMGFSKSVNEARS-----KMDVAQSELDIYLSRHN 514
+++E Q L K+ E E E++ +S+ ++ + AQ E I R N
Sbjct: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
Query: 515 T--AVSQLTKAKEALIAASETLKER-----KAAIRDIEGKLPQTEQELKEKEKELQKLTQ 567
+ + L + E L +L++R +A ++DIE + + +KE +L K+
Sbjct: 549 SERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEF 608
Query: 568 EETNF-KSLVH--DLFQKVEEAKSSLAMNRSRGKVLDAIIQEKK--SGRIPGIYGRLGDL 622
E+ K L H + ++ EE ++ L ++L I K +I + +L
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSEL 668
Query: 623 GAIDEKYDVAISS---CCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAK 679
+ K + S L+ + ++ + +E N R+N+ + KMA
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE--NLELRRNVESLKCASM-KMAQLQL 725
Query: 680 KMTEIQT-PENTPRLFDLVKV---KDEKIRQAFY-FALRDTLVADNLDQATRVAYQKDRR 734
+ E+++ E + +L+K K E++ ++ + + + L+ + + Q +
Sbjct: 726 ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE 785
Query: 735 WRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQ 794
+ + ++ Q ++++ SK ++ + +E ++ K + QL+ ++K+ Q
Sbjct: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 795 EQK-VQLEERVVKLRHSEREMRNTLEK----FTASIQRLIEQEEYLNVQVKE--LEANVL 847
E K LEE VK+ + E+E TL K + S RL E E+ VK ++ L
Sbjct: 846 EIKDTTLEENNVKIGNLEKE-NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
Query: 848 AT-----APDKKKQKLLEENVSAFKTEYDAVA--------EKAGKVEAEVKRLHNTIVEI 894
T +K K + + ++ E + + ++ ++ K L + +
Sbjct: 905 VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLEST 964
Query: 895 NNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRN---LQKAQDSVLRTEK----- 946
L+ +++K+ + +L+E + + + +KT +N L++ QD +
Sbjct: 965 LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPIS 1024
Query: 947 -EIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEH 1005
E E+E + T EL ++D+ EV +N NA +Q E + L +LK ++ +
Sbjct: 1025 GEDNKWERESQETTRELLKVKDRLIEVERN-NAT------LQAEKQALKTQLKQLETQNN 1077
Query: 1006 ALQKDALSIK---LKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNP--IEEISVLSP 1060
LQ L+++ + L++ + + N+K++ + ++ S + N + + S L
Sbjct: 1078 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1137
Query: 1061 EDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSF 1120
E+ IK + + + L I +++K E L+ ++ +E + + + +
Sbjct: 1138 ENESVIKEREDLKSLYDSL-------------IKDHEKLELLHERQASEYESLISKHGTL 1184
Query: 1121 RQAYEDL 1127
+ A+++L
Sbjct: 1185 KSAHKNL 1191
Score = 87.0 bits (214), Expect = 1e-16
Identities = 155/794 (19%), Positives = 333/794 (41%), Gaps = 132/794 (16%)
Query: 368 DVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEE 427
++ D + K+ ++ + +EE E+ E Q+ +LK + L + + +E
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
Query: 428 FKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEV------MDSLKQETQGLQKEKESR 481
++ E R + LE E + +++L ++ ++ LK++ Q L + K
Sbjct: 312 LDAL--------REKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML 363
Query: 482 EKELMGFSKSVNEARSKM--DVAQSELDIYLSRHNTAVSQLTKAK--EALIAASETLKER 537
E +L G ARS ++ + L + H+ + + K E L+ + TL+
Sbjct: 364 EDQLEG-----TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418
Query: 538 KAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAM-NRSR 596
+ D E E E + EL + Q KSL H++ + L M N+S
Sbjct: 419 QKQSMD-ESLHLGWELEQISRTSELSEAPQ-----KSLGHEVNELTSSRLLKLEMENQSL 472
Query: 597 GKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVN 656
K + E+ + + G + + EK + +S L+ +V Q C N
Sbjct: 473 TKTV-----EELRTTVDSVEGNASKILKM-EKENQRLSKKVEILENEIVQEKQSLQNCQN 526
Query: 657 FLKRQNIGVATFIGLDKMAVWAKKMTEIQT-PENTPRLFDLVKVKDEKIRQAFYFALRDT 715
K D M A+ I+T EN+ R +++ ++E + Q
Sbjct: 527 LSK------------DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT-------- 566
Query: 716 LVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEE 775
+L Q ++++ + R + + + +I+ +S I+ + +
Sbjct: 567 --VSSLRQRSQIS--AEARVKDIEKENKILHES--------------------IKETSSK 602
Query: 776 VNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYL 835
++K+E + + K+ +E+ + EE +L H E+E L+K +++ E+ E L
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE-NELLQKKITNLKITCEKIEAL 661
Query: 836 NVQVKELEANVLATAPDKKKQKLLEENVSAFKT---EYDAVAEKAGKVEAEVKRLHNTI- 891
+ ELE ++ + L++ + +FK + +++ ++ +++ E L +
Sbjct: 662 EQENSELE----------RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
Query: 892 -----------VEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDS 940
+++ N +L++++++L K + L + +V+ + D Q+ Q +
Sbjct: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 941 VLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVI 1000
+ + K+I+ E E+ DL E ++L+ E+ + + L +++KE+++L QE +
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEEL----KISSKRLEQLEKENKSLEQETSQL 827
Query: 1001 QENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLH-PIEDNPIEEISVLS 1059
++++ L+K+ ++ + E D + E+N KI KE +S I + L
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 1060 PEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRV-AELDKITYERD 1118
E+ E +K A ++ + L + E E+L Q++ +L+K+T+E +
Sbjct: 888 KENKELVKR--------ATIDIK------TLVTLREDLVSEKLKTQQMNNDLEKLTHELE 933
Query: 1119 SFRQAYEDLRKQRL 1132
L K+RL
Sbjct: 934 KI-----GLNKERL 942
Score = 77.8 bits (190), Expect = 6e-14
Identities = 180/857 (21%), Positives = 345/857 (40%), Gaps = 191/857 (22%)
Query: 267 IKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGE----KNIAIEFLTLENEI--FRKKN 320
+K + + +IL+E E +++ +E EK ++ E K LENE+ K+N
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKEN 641
Query: 321 HVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKIT 380
+ LQK+I ++ EKI E E+ N +E++ +N+ +K T +T
Sbjct: 642 EL-------LQKKITNLKITCEKI-----EALEQEN---SELERENRKLKKTLDSFKNLT 686
Query: 381 KFIEENKEKFTQLDLEDVQVR---EKLKHATSKAKKLE---KQLQKDKEKVEE----FKS 430
+E +++ +QLD E++++R E LK A+ K +L+ K+L+ +KE++++ K+
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 431 IPAKSNNI---INETTTRNNALEKEKEKEEKKLKEV---MDSLKQETQGLQKEKES---- 480
K+ + N L+K E KK++++ + L+ E Q LQK E
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 481 --REKELMGFSKSVNEARSKMDVAQSEL--------------DIYLSRHNTAVSQLTKA- 523
R ++L +KS+ + S+++ + +L D L +N + L K
Sbjct: 807 SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866
Query: 524 ----------KEALIAASETLKERKAAIR----DIEGKLPQTEQELKEKEK------ELQ 563
KE+ + E KE K ++ DI+ + E + EK K +L+
Sbjct: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
Query: 564 KLTQE----ETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRL 619
KLT E N + L+HD Q ++++ L ++ + ++ E K +I + RL
Sbjct: 927 KLTHELEKIGLNKERLLHDE-QSTDDSRYKLLESKLESTLKKSL--EIKEEKIAALEARL 983
Query: 620 GDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAK 679
+ +++ + + +Y + + V G D W +
Sbjct: 984 EESTNYNQQLRQELKTV--KKNYEALKQRQDEERMVQ-------SSPPISGEDNK--WER 1032
Query: 680 KMTEIQTPENTPRLFDLVKVKDEKI------------RQAFYFALRDTLVADNLDQATRV 727
+ E T R +L+KVKD I +QA L+ +N QA +
Sbjct: 1033 ESQE------TTR--ELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1084
Query: 728 AYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDS 787
A Q+ + V+LQ EQ+ T+ +K +++ +N + L N +
Sbjct: 1085 ALQR----QTVSLQ----EQNTTLQTQNAK-----------LQVENSTLNSQSTSLMNQN 1125
Query: 788 KKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQE--EY----------- 834
+ + Q E V+K R + + ++L K ++ L E++ EY
Sbjct: 1126 AQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLK 1185
Query: 835 -----LNVQVKELEANVLATAPDK-------KKQKLLEENVSAFKTEYDAVAEKAGKVEA 882
L V+ ++LE K K K+ +E + ++ VA + K+
Sbjct: 1186 SAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCG 1245
Query: 883 EVKRLHNTIVEI------------------NNHKL------------KAQQDKLDKINKQ 912
E RL++T ++ NN KL K Q +LD + +
Sbjct: 1246 ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTK 1305
Query: 913 LDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDL-TAELKSLEDKAAE 971
L+ +++ + ++ +R+L +++ + + + E DL E + DK E
Sbjct: 1306 LNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNE 1365
Query: 972 VVKNTNAAEESLPEIQK 988
+ + EE + + K
Sbjct: 1366 LRRQKEKLEEKIMDQYK 1382
Score = 74.7 bits (182), Expect = 5e-13
Identities = 156/824 (18%), Positives = 341/824 (41%), Gaps = 126/824 (15%)
Query: 376 LNKITKFIEENKEKFTQLDLEDVQVREK---LKHATSKAKKL-------EKQLQKDKEKV 425
+ +I + +E ++ + L +V + K + T + KKL Q QK +E +
Sbjct: 83 VRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFI 142
Query: 426 E-----EFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKES 480
E +F + A + +I T + N + + EV D +++ + L K
Sbjct: 143 ERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQ-------WMEVTDMSQEDIEPLLKNMAL 195
Query: 481 REKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAA 540
K L+ + + + +++++ ++ H ++ +Q + +E+ +
Sbjct: 196 HLKRLI--DERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM-KRTESRQHLSVE 252
Query: 541 IRDIEGKLPQTEQELKEKEKEL----QKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSR 596
+ D + K+ + QEL+EK ++L Q+L Q E K L + + +A+S+ M R
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA-RMYRDE 311
Query: 597 GKVL--DAIIQEKKSGRIPGIYGRLGDL----GAIDE-KYDVAISSCCHALDYIVVDSID 649
L A+ +K + RL D+ ++E K D + + ++
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTR 371
Query: 650 IAQECVNFLKRQNIGV-ATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAF 708
+ ++ L+++N+ + A ++ +K E EN + DE +
Sbjct: 372 ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG- 430
Query: 709 YFALRDTLVADNLDQATR--VAYQKDRRWRVVTLQGQIIEQSGTMT------------GG 754
+ L L +A + + ++ + L+ ++ QS T T G
Sbjct: 431 -WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 755 GSKVMKGRMGS---SLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLR-HS 810
SK++K + S +EI E E+ + + LQN + + ++K QLE+ + LR +S
Sbjct: 490 ASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENS 549
Query: 811 EREMRNTLEKFTASIQRLIEQE-EYLNVQVKELEANVLATAPDK-----KKQKLLEENVS 864
ER++ +++EQE E+LN V L +A + K+ K+L E++
Sbjct: 550 ERQI------------KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 865 AFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQ-----QDKLDKINKQLDECASA 919
+ K K+E E +++ E+ ++K K + +++L + K+ +
Sbjct: 598 -------ETSSKLSKIEFEKRQIKK---ELEHYKEKGERAEELENELHHLEKENELLQKK 647
Query: 920 ITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEV------- 972
IT ++ + + L++ + R +++K T +LT +L+SLE + +++
Sbjct: 648 ITNLKITCEKIEA-LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706
Query: 973 ---VKNTNAAEESLPEIQKEHRNL----------LQELKVIQENEHALQKDALSIKLKLE 1019
V++ A + ++Q E++ L L+ LK + L+ + ++ +
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
Query: 1020 QIDGHIAEHNSKIKYWHKEISKISL--HPIEDNPIEEISVLSPEDLEAIKNPDSITNQIA 1077
++ + N KI+ E+ + + ++ N +EE+ + S + K S+ + +
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKRLEQLEKENKSLEQETS 825
Query: 1078 LLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFR 1121
LE ++ +KE L++ AE+ T E ++ +
Sbjct: 826 QLEKDKKQL-----------EKENKRLRQQAEIKDTTLEENNVK 858
Score = 43.5 bits (101), Expect = 0.001
Identities = 77/389 (19%), Positives = 160/389 (41%), Gaps = 30/389 (7%)
Query: 221 DHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGR-LNEPIKVLCRRVEILNE 279
D +R+ +L+ ++E + + E + LE+ + L + +K + + E L +
Sbjct: 950 DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ 1009
Query: 280 HRGEKLNRVKMVEKEKDALEGEKN--------IAIEFLTLENEIFR--KKNHVCQYYIYE 329
+ E+ +MV+ + GE N E L +++ + + N Q
Sbjct: 1010 RQDEE----RMVQSSPP-ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQA 1064
Query: 330 LQKRIAEMETQKEKIHEDTKEINEKSNILSNE---MKAKNKDVKDTEKKLN-KITKFIEE 385
L+ ++ ++ETQ + + ++ L + ++ +N ++ LN + T + +
Sbjct: 1065 LKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQ 1124
Query: 386 NKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKS-NNIINETTT 444
N + Q + + +K K L L KD EK+E A ++I++ T
Sbjct: 1125 NAQLLIQQSSLENENESVIKERED-LKSLYDSLIKDHEKLELLHERQASEYESLISKHGT 1183
Query: 445 RNNALEKEKEKEEKKLKEVMDSL---KQETQGLQKEKESREKELMGFSKSVNEARSKMDV 501
+A K E E + L++ + L K + + L+K + +++++ +K+ ++
Sbjct: 1184 LKSA-HKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKK 1242
Query: 502 AQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKE 561
E D R N SQL K E L + LK + + +L +LKE+ ++
Sbjct: 1243 LCGEND----RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQ 1298
Query: 562 LQKLTQEETNFKSLVHDLFQKVEEAKSSL 590
L + + N L+ L +EE L
Sbjct: 1299 LDITSTKLNNQCELLSQLKGNLEEENRHL 1327
Score = 37.4 bits (85), Expect = 0.093
Identities = 47/230 (20%), Positives = 96/230 (41%), Gaps = 32/230 (13%)
Query: 936 KAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQ 995
K +S E+ D + ++ L EL+ ++ + + E L +Q+E+ NLL
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 996 E---LKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPI 1052
+ ++ ++ AL++ A+ + KLE E I+++ + ++ EDN +
Sbjct: 301 DARSARMYRDELDALREKAVRVD-KLESEVSRYKERLHDIEFYKARVEELK----EDNQV 355
Query: 1053 -EEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELD 1111
E + + LE + + HE+ +KE L L+ A+L
Sbjct: 356 LLETKTMLEDQLEGTRARSD----------KLHEL-----------EKENLQLK--AKLH 392
Query: 1112 KITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAEL 1161
+ ERD R+ E+L ++ + MA + L +++ + +EL
Sbjct: 393 DMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSEL 442
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 115 bits (287), Expect = 4e-25
Identities = 162/850 (19%), Positives = 360/850 (42%), Gaps = 136/850 (16%)
Query: 286 NRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHV--CQYYIYELQKRIAEMETQKEK 343
N K+++ EK+ K + I LENEI ++K + CQ +L K A++E E
Sbjct: 489 NASKILKMEKENQRLSKKVEI----LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
Query: 344 IHEDTK-------EINEKSNILSNEMKAKNK-----DVKDTEKKLNKITKFIEENKEKFT 391
+ E+++ + NE N + ++ +++ VKD EK+ + + I+E K +
Sbjct: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
Query: 392 QLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEK 451
+++ E Q++++L+H K ++ E +L+ + +E+ + K + T + ALE+
Sbjct: 605 KIEFEKRQIKKELEHYKEKGERAE-ELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
Query: 452 EK---EKEEKKLKEVMDSLKQET---QGLQKEKESREKELMGFSKSVNEAR--------- 496
E E+E +KLK+ +DS K T + L+KE ++E + ++V +
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 497 ----------------------------SKMDVAQSELDIY-------LSRHNTAVSQLT 521
+++V+ LDI L N + QL
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 522 KAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQ 581
+ L ++TL++ ++ +L Q E+E K E+E +L +++ +
Sbjct: 784 SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDK-----------K 832
Query: 582 KVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALD 641
++E+ L R + ++ D ++E ++G+L EK + +S
Sbjct: 833 QLEKENKRL---RQQAEIKDTTLEENNV--------KIGNL----EKENKTLSKEIGIYK 877
Query: 642 YIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKD 701
V ++ +E +KR I + T + L + V K T+ + +L K+
Sbjct: 878 ESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGL 937
Query: 702 EKIRQAF-------YFALRDTLVADNLDQATRVAYQK----DRRWRVVTLQGQIIEQSGT 750
K R + L ++ + L ++ + +K + R T Q + Q
Sbjct: 938 NKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELK 997
Query: 751 MTGGGSKVMKGRMGSSLVIEIS---EEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKL 807
+ +K R +++ S E NK E + Q +++ ++++++ +++E L
Sbjct: 998 TVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1057
Query: 808 RHSEREMR----------NTLEKFTASIQR--LIEQEEYLNVQVKELEANVLATAPDKKK 855
+ ++ ++ N L+ ++QR + QE+ +Q + + V + + +
Sbjct: 1058 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1117
Query: 856 QKLLEENVSAF--KTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQL 913
L+ +N ++ + E K ++K L++++++ ++ KL+ ++ + L
Sbjct: 1118 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK-DHEKLELLHERQASEYESL 1176
Query: 914 DECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEK----EVDDLTAELKSLEDKA 969
+ A ++ R+L+ + +L+ + +++D EK E + + E K+ E A
Sbjct: 1177 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1236
Query: 970 AEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHN 1029
AE K + + + LL+E +V+Q + L+ + KL+ +++
Sbjct: 1237 AEYKKLCGEND----RLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEF---- 1288
Query: 1030 SKIKYWHKEI 1039
SK+K ++++
Sbjct: 1289 SKLKEQYQQL 1298
Score = 101 bits (251), Expect = 5e-21
Identities = 194/966 (20%), Positives = 411/966 (42%), Gaps = 134/966 (13%)
Query: 252 EYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTL 311
E E ++ C + E +++ +R++ N + +M E DAL EK + ++ L
Sbjct: 269 EKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR-EKAVRVDKLES 327
Query: 312 ENEIFRKKNHVCQYY---IYELQK--------------RIAEMETQKEKIHEDTKEINEK 354
E ++++ H ++Y + EL++ ++ + +K+HE EK
Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHE-----LEK 382
Query: 355 SNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKL 414
N+ ++KAK + D E + + K IEE E+ L++ Q ++ H + +++
Sbjct: 383 ENL---QLKAK---LHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQI 436
Query: 415 EKQLQKDKEKVEEFKSIPAKS-NNIINE-TTTRNNALEKEKE---KEEKKLKEVMDS--- 466
+ E P KS + +NE T++R LE E + K ++L+ +DS
Sbjct: 437 --------SRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
Query: 467 -------LKQETQGLQKEKESREKELMGFSKSVNEARS-----KMDVAQSELDIYLSRHN 514
+++E Q L K+ E E E++ +S+ ++ + AQ E I R N
Sbjct: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
Query: 515 T--AVSQLTKAKEALIAASETLKER-----KAAIRDIEGKLPQTEQELKEKEKELQKLTQ 567
+ + L + E L +L++R +A ++DIE + + +KE +L K+
Sbjct: 549 SERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEF 608
Query: 568 EETNF-KSLVH--DLFQKVEEAKSSLAMNRSRGKVLDAIIQEKK--SGRIPGIYGRLGDL 622
E+ K L H + ++ EE ++ L ++L I K +I + +L
Sbjct: 609 EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSEL 668
Query: 623 GAIDEKYDVAISS---CCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAK 679
+ K + S L+ + ++ + +E N R+N+ + KMA
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE--NLELRRNVESLKCASM-KMAQLQL 725
Query: 680 KMTEIQT-PENTPRLFDLVKV---KDEKIRQAFY-FALRDTLVADNLDQATRVAYQKDRR 734
+ E+++ E + +L+K K E++ ++ + + + L+ + + Q +
Sbjct: 726 ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE 785
Query: 735 WRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQ 794
+ + ++ Q ++++ SK ++ + +E ++ K + QL+ ++K+ Q
Sbjct: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 795 EQK-VQLEERVVKLRHSEREMRNTLEK----FTASIQRLIEQEEYLNVQVKELEANV--- 846
E K LEE VK+ + E+E TL K + S RL E E+ VK ++
Sbjct: 846 EIKDTTLEENNVKIGNLEKE-NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
Query: 847 LATAPDKKKQKLLEENVSAFKTEYDAVAEKAG-----------KVEAEVKRLHNTIVEIN 895
+ D +KL + ++ + EK G + K L + +
Sbjct: 905 VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTL 964
Query: 896 NHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRN---LQKAQDSVLRTEK------ 946
L+ +++K+ + +L+E + + + +KT +N L++ QD +
Sbjct: 965 KKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISG 1024
Query: 947 EIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHA 1006
E E+E + T EL ++D+ EV +N NA +Q E + L +LK ++ +
Sbjct: 1025 EDNKWERESQETTRELLKVKDRLIEVERN-NAT------LQAEKQALKTQLKQLETQNNN 1077
Query: 1007 LQKDALSIK---LKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNP--IEEISVLSPE 1061
LQ L+++ + L++ + + N+K++ + ++ S + N + + S L E
Sbjct: 1078 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1137
Query: 1062 DLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFR 1121
+ IK + + + L I +++K E L+ ++ +E + + + + +
Sbjct: 1138 NESVIKEREDLKSLYDSL-------------IKDHEKLELLHERQASEYESLISKHGTLK 1184
Query: 1122 QAYEDL 1127
A+++L
Sbjct: 1185 SAHKNL 1190
Score = 87.4 bits (215), Expect = 8e-17
Identities = 162/857 (18%), Positives = 354/857 (41%), Gaps = 138/857 (16%)
Query: 368 DVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEE 427
++ D + K+ ++ + +EE E+ E Q+ +LK + L + + +E
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
Query: 428 FKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEV------MDSLKQETQGLQKEKESR 481
++ E R + LE E + +++L ++ ++ LK++ Q L + K
Sbjct: 312 LDAL--------REKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTML 363
Query: 482 EKELMGFSKSVNEARSKM--DVAQSELDIYLSRHNTAVSQLTKAK--EALIAASETLKER 537
E +L G ARS ++ + L + H+ + + K E L+ + TL+
Sbjct: 364 EDQLEG-----TRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA 418
Query: 538 KAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAM-NRSR 596
+ D E E E + EL + Q KSL H++ + L M N+S
Sbjct: 419 QKQSMD-ESLHLGWELEQISRTSELSEAPQ-----KSLGHEVNELTSSRLLKLEMENQSL 472
Query: 597 GKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVN 656
K + E+ + + G + + EK + +S L+ +V Q C N
Sbjct: 473 TKTV-----EELRTTVDSVEGNASKILKM-EKENQRLSKKVEILENEIVQEKQSLQNCQN 526
Query: 657 FLKRQNIGVATFIGLDKMAVWAKKMTEIQT-PENTPRLFDLVKVKDEKIRQAFYFALRDT 715
K D M A+ I+T EN+ R +++ ++E + Q
Sbjct: 527 LSK------------DLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT-------- 566
Query: 716 LVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEE 775
+L Q ++++ + R + + + +I+ +S I+ + +
Sbjct: 567 --VSSLRQRSQIS--AEARVKDIEKENKILHES--------------------IKETSSK 602
Query: 776 VNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYL 835
++K+E + + K+ +E+ + EE +L H E+E L+K +++ E+ E L
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE-NELLQKKITNLKITCEKIEAL 661
Query: 836 NVQVKELEANVLATAPDKKKQKLLEENVSAFKT---EYDAVAEKAGKVEAEVKRLHNTI- 891
+ ELE ++ + L++ + +FK + +++ ++ +++ E L +
Sbjct: 662 EQENSELE----------RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
Query: 892 -----------VEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDS 940
+++ N +L++++++L K + L + +V+ + D Q+ Q +
Sbjct: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
Query: 941 VLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVI 1000
+ + K+I+ E E+ DL E ++L+ E+ + + L +++KE+++L QE +
Sbjct: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEEL----KISSKRLEQLEKENKSLEQETSQL 827
Query: 1001 QENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLH-PIEDNPIEEISVLS 1059
++++ L+K+ ++ + E D + E+N KI KE +S I + L
Sbjct: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
Query: 1060 PEDLEAIKNPD-------SITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDK 1112
E+ E +K ++ + + + +M +L + +K L +R+ ++
Sbjct: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947
Query: 1113 ITYER--------DSFRQAYEDLRKQRLNEFMAGFYIITN----------KLKENYQMLT 1154
T +R +S + +++++++ A TN +K+NY+ L
Sbjct: 948 STDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALK 1007
Query: 1155 LGGDAELELVDSLDPFS 1171
D E +V S P S
Sbjct: 1008 QRQDEE-RMVQSSPPIS 1023
Score = 82.4 bits (202), Expect = 3e-15
Identities = 183/852 (21%), Positives = 350/852 (41%), Gaps = 182/852 (21%)
Query: 267 IKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGE----KNIAIEFLTLENEI--FRKKN 320
+K + + +IL+E E +++ +E EK ++ E K LENE+ K+N
Sbjct: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKEN 641
Query: 321 HVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKIT 380
+ LQK+I ++ EKI E E+ N +E++ +N+ +K T +T
Sbjct: 642 EL-------LQKKITNLKITCEKI-----EALEQEN---SELERENRKLKKTLDSFKNLT 686
Query: 381 KFIEENKEKFTQLDLEDVQVR---EKLKHATSKAKKLE---KQLQKDKEKVEE----FKS 430
+E +++ +QLD E++++R E LK A+ K +L+ K+L+ +KE++++ K+
Sbjct: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
Query: 431 IPAKSNNI---INETTTRNNALEKEKEKEEKKLKEV---MDSLKQETQGLQKEKES---- 480
K+ + N L+K E KK++++ + L+ E Q LQK E
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 481 --REKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETL---- 534
R ++L +KS+ + S+++ + +L+ + N + Q + K+ + +
Sbjct: 807 SKRLEQLEKENKSLEQETSQLEKDKKQLE----KENKRLRQQAEIKDTTLEENNVKIGNL 862
Query: 535 -KERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEET-NFKSLVHDLFQKVEEAKSSLAM 592
KE K ++I G ++ LKE EKE ++L + T + K+LV V E + M
Sbjct: 863 EKENKTLSKEI-GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQM 921
Query: 593 NRSRGKV---LDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSID 649
N K+ L+ I K+ L D + D++Y + S L+ + S++
Sbjct: 922 NNDLEKLTHELEKIGLNKER--------LLHDEQSTDDRYKLLESK----LESTLKKSLE 969
Query: 650 IAQECVNFLK-------------RQNIGVA--TFIGLDKMAVWAKKMTEIQTP------- 687
I +E + L+ RQ + + L K ++M + P
Sbjct: 970 IKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEAL-KQRQDEERMVQSSPPISGEDNK 1028
Query: 688 ---ENTPRLFDLVKVKDEKI------------RQAFYFALRDTLVADNLDQATRVAYQKD 732
E+ +L+KVKD I +QA L+ +N QA +A Q+
Sbjct: 1029 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR- 1087
Query: 733 RRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQ 792
+ V+LQ EQ+ T+ +K +++ +N + L N + + +
Sbjct: 1088 ---QTVSLQ----EQNTTLQTQNAK-----------LQVENSTLNSQSTSLMNQNAQLLI 1129
Query: 793 IQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQE--EY---------------- 834
Q E V+K R + + ++L K ++ L E++ EY
Sbjct: 1130 QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1189
Query: 835 LNVQVKELEANVLATAPDK-------KKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRL 887
L V+ ++LE K K K+ +E + ++ VA + K+ E RL
Sbjct: 1190 LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRL 1249
Query: 888 HNTIVEI------------------NNHKL------------KAQQDKLDKINKQLDECA 917
++T ++ NN KL K Q +LD + +L+
Sbjct: 1250 NHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQC 1309
Query: 918 SAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDL-TAELKSLEDKAAEVVKNT 976
+++ + ++ +R+L +++ + + + E DL E + DK E+ +
Sbjct: 1310 ELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQK 1369
Query: 977 NAAEESLPEIQK 988
EE + + K
Sbjct: 1370 EKLEEKIMDQYK 1381
Score = 74.7 bits (182), Expect = 5e-13
Identities = 156/824 (18%), Positives = 341/824 (41%), Gaps = 126/824 (15%)
Query: 376 LNKITKFIEENKEKFTQLDLEDVQVREK---LKHATSKAKKL-------EKQLQKDKEKV 425
+ +I + +E ++ + L +V + K + T + KKL Q QK +E +
Sbjct: 83 VRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFI 142
Query: 426 E-----EFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKES 480
E +F + A + +I T + N + + EV D +++ + L K
Sbjct: 143 ERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQ-------WMEVTDMSQEDIEPLLKNMAL 195
Query: 481 REKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAA 540
K L+ + + + +++++ ++ H ++ +Q + +E+ +
Sbjct: 196 HLKRLI--DERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM-KRTESRQHLSVE 252
Query: 541 IRDIEGKLPQTEQELKEKEKEL----QKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSR 596
+ D + K+ + QEL+EK ++L Q+L Q E K L + + +A+S+ M R
Sbjct: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSA-RMYRDE 311
Query: 597 GKVL--DAIIQEKKSGRIPGIYGRLGDL----GAIDE-KYDVAISSCCHALDYIVVDSID 649
L A+ +K + RL D+ ++E K D + + ++
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTR 371
Query: 650 IAQECVNFLKRQNIGV-ATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAF 708
+ ++ L+++N+ + A ++ +K E EN + DE +
Sbjct: 372 ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG- 430
Query: 709 YFALRDTLVADNLDQATR--VAYQKDRRWRVVTLQGQIIEQSGTMT------------GG 754
+ L L +A + + ++ + L+ ++ QS T T G
Sbjct: 431 -WELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGN 489
Query: 755 GSKVMKGRMGS---SLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLR-HS 810
SK++K + S +EI E E+ + + LQN + + ++K QLE+ + LR +S
Sbjct: 490 ASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENS 549
Query: 811 EREMRNTLEKFTASIQRLIEQE-EYLNVQVKELEANVLATAPDK-----KKQKLLEENVS 864
ER++ +++EQE E+LN V L +A + K+ K+L E++
Sbjct: 550 ERQI------------KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK 597
Query: 865 AFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQ-----QDKLDKINKQLDECASA 919
+ K K+E E +++ E+ ++K K + +++L + K+ +
Sbjct: 598 -------ETSSKLSKIEFEKRQIKK---ELEHYKEKGERAEELENELHHLEKENELLQKK 647
Query: 920 ITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEV------- 972
IT ++ + + L++ + R +++K T +LT +L+SLE + +++
Sbjct: 648 ITNLKITCEKIEA-LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL 706
Query: 973 ---VKNTNAAEESLPEIQKEHRNL----------LQELKVIQENEHALQKDALSIKLKLE 1019
V++ A + ++Q E++ L L+ LK + L+ + ++ +
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
Query: 1020 QIDGHIAEHNSKIKYWHKEISKISL--HPIEDNPIEEISVLSPEDLEAIKNPDSITNQIA 1077
++ + N KI+ E+ + + ++ N +EE+ + S + K S+ + +
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKRLEQLEKENKSLEQETS 825
Query: 1078 LLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFR 1121
LE ++ +KE L++ AE+ T E ++ +
Sbjct: 826 QLEKDKKQL-----------EKENKRLRQQAEIKDTTLEENNVK 858
Score = 37.4 bits (85), Expect = 0.093
Identities = 47/230 (20%), Positives = 96/230 (41%), Gaps = 32/230 (13%)
Query: 936 KAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQ 995
K +S E+ D + ++ L EL+ ++ + + E L +Q+E+ NLL
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 996 E---LKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPI 1052
+ ++ ++ AL++ A+ + KLE E I+++ + ++ EDN +
Sbjct: 301 DARSARMYRDELDALREKAVRVD-KLESEVSRYKERLHDIEFYKARVEELK----EDNQV 355
Query: 1053 -EEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELD 1111
E + + LE + + HE+ +KE L L+ A+L
Sbjct: 356 LLETKTMLEDQLEGTRARSD----------KLHEL-----------EKENLQLK--AKLH 392
Query: 1112 KITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAEL 1161
+ ERD R+ E+L ++ + MA + L +++ + +EL
Sbjct: 393 DMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSEL 442
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 111 bits (278), Expect = 4e-24
Identities = 152/878 (17%), Positives = 371/878 (42%), Gaps = 82/878 (9%)
Query: 291 VEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHED--- 347
+E++ L EKNI E L E E+F + E++ R+A + + E+I D
Sbjct: 878 MERKHQQLLEEKNILAEQLQAETELFAEAE--------EMRARLAAKKQELEEILHDLES 929
Query: 348 -TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKH 406
+E E++ IL NE K ++D E++L++ EE + +L LE V K+K
Sbjct: 930 RVEEEEERNQILQNEKKKMQAHIQDLEEQLDE-----EEGARQ--KLQLEKVTAEAKIKK 982
Query: 407 ATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDS 466
+ LE Q K ++ + + A+ ++ + E + L K + K+E + ++ +
Sbjct: 983 MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042
Query: 467 LKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEA 526
LK+E + ++E E +++L G + + + +++ EL + QL K +E
Sbjct: 1043 LKKE-EKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKL----------QLAKKEEE 1091
Query: 527 LIAA-----SETLKERKA--AIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDL 579
L A ETL + A +R+++ ++ + +++ + ++ K +++ + + L
Sbjct: 1092 LQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEAL 1151
Query: 580 FQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHA 639
++E+ + A + + + E K + + +++ A+
Sbjct: 1152 KTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQ 1211
Query: 640 LDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKV 699
L+ ++ ++ L+ N +A + K+ K +E + + ++ +L
Sbjct: 1212 LEQAKRFKANL-EKNKQGLETDNKELACEV---KVLQQVKAESEHKRKKLDAQVQELHAK 1267
Query: 700 KDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRW-----RVVTLQGQIIEQSGTMTGG 754
E R A + + + + LD + + + +++ +L+ Q+ + +
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELL--- 1324
Query: 755 GSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREM 814
+ + ++ S I EEE N ++ Q + + + +++Q + L+ ++ + +
Sbjct: 1325 -QEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD 1383
Query: 815 RNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA 874
T+E + ++L++ E L+ + LE LA +K + L++ + + D
Sbjct: 1384 LGTIESLEEAKKKLLKDAEALS---QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQR 1440
Query: 875 EKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNL 934
+ A +E + K+ + E + + +++ D + + + + R L
Sbjct: 1441 QVASNLEKKQKKFDQLLAEEKSISARYAEER--------DRAEAEAREKETKALSLARAL 1492
Query: 935 QKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLL 994
++A ++ E++ K +++DL + + E+ K+ A E+ + E++ + L
Sbjct: 1493 EEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE 1552
Query: 995 QELKVIQENEHALQKDALSIKLKLEQ-IDGHIAEHNSKIKYWHKEISKISLHPIEDNPIE 1053
EL+ ++ + L+ + ++K + E+ + ++ K + K++ ++ ++
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQR 1612
Query: 1054 EISVLSPEDLE------------AIKNPDSITNQIALLEARCHEMKPNL--------GAI 1093
++V S + +E A K D + Q+ L+A+ + + L
Sbjct: 1613 ALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672
Query: 1094 AEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQR 1131
A+ K+ E+ AE+ ++ E S +A ++R
Sbjct: 1673 AQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER 1710
Score = 107 bits (267), Expect = 7e-23
Identities = 173/834 (20%), Positives = 342/834 (41%), Gaps = 97/834 (11%)
Query: 361 EMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQK 420
E++AK++++ ++K K+ +EE + K QL E + E+L+ T + E+ +
Sbjct: 853 ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRAR 912
Query: 421 DKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQE---TQGLQKE 477
K +E + I + + E RN L+ EK+K + ++++ + L +E Q LQ E
Sbjct: 913 LAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLE 972
Query: 478 KESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKER 537
K + E ++ + + + E + R SQL + +E ++ ++
Sbjct: 973 KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQ 1032
Query: 538 KAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRG 597
+ I D+E +L + E+ +E EK +KL E T+ + + +L +++E K LA
Sbjct: 1033 EVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEEL 1092
Query: 598 KVLDAIIQEK---KSGRIPGIYGRLGDLGAIDEKYDVA-------------ISSCCHALD 641
+ A ++ K+ + + + + E ++ +S AL
Sbjct: 1093 QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALK 1152
Query: 642 YIVVDSID--IAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKV 699
+ D++D AQ+ + + Q + L K K E Q + R ++
Sbjct: 1153 TELEDTLDTTAAQQELRTKREQEVA-----ELKKALEEETKNHEAQIQDMRQRHATALEE 1207
Query: 700 KDEKIRQAFYFAL-----RDTLVADNLDQATRV----AYQKDRRWRVVTLQGQIIEQSGT 750
E++ QA F + L DN + A V + + + L Q+ E
Sbjct: 1208 LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAK 1267
Query: 751 MTGG----------GSKVMKGRMGSSLVIEISE-------EEVNKMESQLQNDSKKAMQI 793
++ G SK+ S ++E +E ++ +ESQLQ+ + +
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEE 1327
Query: 794 QEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLA----T 849
QK+ L R+ +L E +N+L+ EQ+E K LE VLA
Sbjct: 1328 TRQKLNLSSRIRQL----EEEKNSLQ----------EQQEEEEEARKNLEKQVLALQSQL 1373
Query: 850 APDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKI 909
A KKK +++++ ++ +A + EA +RL + DKL+K
Sbjct: 1374 ADTKKK---VDDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL---------AYDKLEKT 1421
Query: 910 NKQLDECASAITKAQVAIKTADRNLQKAQ---DSVLRTEKEIKDT-EKEVDDLTAELKSL 965
+L + +T + NL+K Q D +L EK I +E D AE +
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREK 1481
Query: 966 EDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQ-------ENEHALQKDALSIKLKL 1018
E KA + + A E+ E +++++ L +++ + +N H L+K +++ ++
Sbjct: 1482 ETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV 1541
Query: 1019 EQIDGHIAEHNSKIKYWHKEISKISLH-PIEDNPIEEISVLSPEDLEAIKNPDSITNQIA 1077
E++ + E +++ E +K+ L ++ + L D + + + Q+
Sbjct: 1542 EEMRTQLEELEDELQ--ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1599
Query: 1078 LLEARCHEMKPNLGAIAEYKKKEELYLQRV-AELDKITYERDSFRQAYEDLRKQ 1130
LEA + + KKK E+ L+ + A+++ RD + L+ Q
Sbjct: 1600 ELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ 1653
Score = 100 bits (249), Expect = 9e-21
Identities = 180/914 (19%), Positives = 364/914 (39%), Gaps = 154/914 (16%)
Query: 312 ENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKD 371
++E K N + + ELQ +IAE++ E + ++ LS E++A +++D
Sbjct: 1100 DDETLHKNNAL--KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELED 1157
Query: 372 T--------------EKKLNKITKFIEENKEKFTQLDLEDVQVR-----EKLKHATSKAK 412
T E+++ ++ K +EE + K + ++D++ R E+L +AK
Sbjct: 1158 TLDTTAAQQELRTKREQEVAELKKALEE-ETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216
Query: 413 KLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQ 472
+ + L+K+K+ +E A ++ + + K+ + + ++L + +
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV 1276
Query: 473 GLQKEKESREKELMGFSKSVNEARS---KMDVAQSELDIYLSRHNTAVSQLTKAKEALIA 529
L ++ + EL S + EA K + L+ L + + T+ K L +
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSS 1336
Query: 530 ASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHD---LFQKVEEA 586
L+E K ++++ + + E+ K EK++ L + + K V D + +EEA
Sbjct: 1337 RIRQLEEEKNSLQE---QQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEA 1393
Query: 587 KSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVD 646
K L K +A+ Q RL + +K + + LD + VD
Sbjct: 1394 KKKLL------KDAEALSQ------------RLEEKALAYDKLEKTKNRLQQELDDLTVD 1435
Query: 647 SIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQ 706
Q N K+Q KK ++ + +EK
Sbjct: 1436 LDHQRQVASNLEKKQ-----------------KKFDQL--------------LAEEKSIS 1464
Query: 707 AFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSS 766
A Y RD A+ ++ T+ + + + Q+ + +M
Sbjct: 1465 ARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMS------ 1518
Query: 767 LVIEISEEEVNKMESQLQNDSKKAM--QIQEQKVQLEERVVKLRHSER-------EMRNT 817
S+++V K +L+ SK+A+ Q++E + QLEE +L+ +E M+
Sbjct: 1519 -----SKDDVGKNVHELEK-SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAM 1572
Query: 818 LEKFTASIQRLIEQEE----YLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAV 873
+F +Q EQ E L QV+ELEA + D++KQ+ L AV
Sbjct: 1573 KAQFERDLQTRDEQNEEKKRLLIKQVRELEAEL----EDERKQRAL------------AV 1616
Query: 874 AEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRN 933
A K K+E ++K L + +++ NK DE + K Q +K R
Sbjct: 1617 ASKK-KMEIDLKDL---------------EAQIEAANKARDEVIKQLRKLQAQMKDYQRE 1660
Query: 934 LQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNL 993
L++A+ S + K++EK++ L AE+ L+++ A + AE+ E+ E N
Sbjct: 1661 LEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720
Query: 994 LQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIE 1053
+ + + L+ ++ +LE+ ++ N + + ++ ++ +
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAA 1780
Query: 1054 EISVLSPEDLE---------------AIKNPDSITNQIALLEARCHEMKPNLGAIAEYKK 1098
+ S + + LE A+K+ T I+ LEA+ +++ L A+ +
Sbjct: 1781 QKSDNARQQLERQNKELKAKLQELEGAVKSKFKAT--ISALEAKIGQLEEQLEQEAKERA 1838
Query: 1099 KEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGD 1158
++R + K + + + + D K+++ + A + +L+E + T
Sbjct: 1839 AANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANA 1898
Query: 1159 AELELVDSLDPFSE 1172
+ +L LD +E
Sbjct: 1899 SRRKLQRELDDATE 1912
Score = 94.4 bits (233), Expect = 6e-19
Identities = 156/777 (20%), Positives = 313/777 (40%), Gaps = 136/777 (17%)
Query: 279 EHRGEKLNRVKM----VEKEKDALEGE-KNIAIEFLTL-----ENEIFRKKNHVCQYYIY 328
E E+L + K +EK K LE + K +A E L E+E RKK +
Sbjct: 1206 EELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKK---LDAQVQ 1262
Query: 329 ELQKRIAEMETQKEKIHEDTKEI-NEKSNILSNEMKAKNKDVK-------------DTEK 374
EL +++E + + ++ E ++ NE N+ + +A+ K +K DT++
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322
Query: 375 KLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEK-------QLQKDKEKVEE 427
L + T+ + QL+ E ++E+ + K LEK QL K+KV++
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382
Query: 428 ----FKSIPAKSNNIINETTTRNNALEKEK------EKEEKKLKEVMDSL-------KQE 470
+S+ ++ + + LE++ EK + +L++ +D L +Q
Sbjct: 1383 DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQV 1442
Query: 471 TQGLQKEKESREKELMGFSKSVN-EARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIA 529
L+K K+ + +L+ KS++ + D A++E + A+S +EAL A
Sbjct: 1443 ASNLEK-KQKKFDQLLAEEKSISARYAEERDRAEAEA---REKETKALSLARALEEALEA 1498
Query: 530 ASETLKERKAAIRDIEGKLPQTE------QELKEKEKELQKLTQEETNFKSLVHDLFQKV 583
E ++ K D+E + + EL++ ++ L++ +E + D Q
Sbjct: 1499 KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558
Query: 584 EEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYI 643
E+AK L +N K Q ++ DL DE+ + +
Sbjct: 1559 EDAKLRLEVNMQAMKA-----QFER------------DLQTRDEQNE-------EKKRLL 1594
Query: 644 VVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEK 703
+ ++ E + K++ + VA +KK EI + ++ K +DE
Sbjct: 1595 IKQVRELEAELEDERKQRALAVA-----------SKKKMEIDLKDLEAQIEAANKARDEV 1643
Query: 704 IRQAFYFALRDTLVADNLDQATR-----VAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKV 758
I+Q + L++A A K+ ++ +L+ +I++ +
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQ-----------L 1692
Query: 759 MKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTL 818
+ S +E+E +++ ++ N + + ++K +LE R+ +L E ++ +
Sbjct: 1693 QEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNM 1752
Query: 819 EKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEEN--------------VS 864
E ++ Q + LN ++ + A D +Q+L +N S
Sbjct: 1753 ELLNDRFRKTTLQVDTLNAELAAERS--AAQKSDNARQQLERQNKELKAKLQELEGAVKS 1810
Query: 865 AFKTEYDAVAEKAGKV------EAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECAS 918
FK A+ K G++ EA+ + N +V KLK +++ + D+
Sbjct: 1811 KFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKE 1870
Query: 919 AITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKN 975
+ KA +K R L++A++ R + ++E+DD T + L + +KN
Sbjct: 1871 QMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGL-SREVSTLKN 1926
Score = 79.0 bits (193), Expect = 3e-14
Identities = 156/740 (21%), Positives = 310/740 (41%), Gaps = 119/740 (16%)
Query: 481 REKELMGFSKSVNEARSKMDVAQSELDIYLSRH------NTAVSQLTKAKEALIAASETL 534
+E+EL + + + + K + EL+ +H +++ +A+ L A +E +
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 535 KERKAAIR-DIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMN 593
+ R AA + ++E L E ++E+E+ Q L E+ ++ + DL ++++E +
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG----- 964
Query: 594 RSRGKV-LDAIIQEKKSGRIPGIYGRLGDLGA--IDEK--YDVAISSCCHALDYIVVDSI 648
+R K+ L+ + E K ++ L D + I EK + I+ C L +
Sbjct: 965 -ARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQL----AEEE 1019
Query: 649 DIAQECVNFLKRQNIGVA-----------TFIGLDKMAVWAKKMTEIQTPENTPRLFDLV 697
+ A+ +Q + ++ T L+K AK+ + +T + ++ +L
Sbjct: 1020 EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK----AKRKLDGETTDLQDQIAELQ 1075
Query: 698 KVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVV-TLQGQIIE-QSGTMTGGG 755
DE Q A ++ + L + K+ +VV LQ QI E Q +
Sbjct: 1076 AQIDELKLQ---LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132
Query: 756 SKVMKGRMGSSLVIEIS------EEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRH 809
S+ + L E+ E+ ++ +Q + +K+ ++ E K LEE + ++
Sbjct: 1133 SRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE---ETKN 1189
Query: 810 SEREMRNTLEKFTASIQRLIEQEEY--------------LNVQVKEL--EANVL--ATAP 851
E ++++ ++ +++ L EQ E L KEL E VL A
Sbjct: 1190 HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAE 1249
Query: 852 DKKKQKLLEENVSAFKTEYD-------AVAEKAGKVEAEVKRLHNTIVEINNHKLK---- 900
+ K+K L+ V + +AEKA K++ E+ + + E +K
Sbjct: 1250 SEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKD 1309
Query: 901 --------------AQQDKLDKIN-----KQLDECASAITKAQVAIKTADRNLQKAQDSV 941
Q++ K+N +QL+E +++ + Q + A +NL+K V
Sbjct: 1310 AASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK---QV 1366
Query: 942 LRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPE-------IQKEHRNLL 994
L + ++ DT+K+VDD ++SLE+ +++K+ A + L E ++K L
Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ 1426
Query: 995 QELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEE 1054
QEL + + ++ A +++ K ++ D +AE S + +E + E +E
Sbjct: 1427 QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE----KE 1482
Query: 1055 ISVLSPEDL--EAIKNPDSITNQIALLEARCHEM---KPNLGA-IAEYKKKEELYLQRVA 1108
LS EA++ + Q L A ++ K ++G + E +K + Q+V
Sbjct: 1483 TKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVE 1542
Query: 1109 ELDKITYERDSFRQAYEDLR 1128
E+ E + QA ED +
Sbjct: 1543 EMRTQLEELEDELQATEDAK 1562
Score = 60.8 bits (146), Expect = 8e-09
Identities = 85/437 (19%), Positives = 172/437 (39%), Gaps = 115/437 (26%)
Query: 275 EILNEHRGEKLN---RVKMVEKEKDAL--------EGEKNIAIEFLTLENEIFRKKNHVC 323
E+L E +KLN R++ +E+EK++L E KN+ + L L++++ K V
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVD 1381
Query: 324 QYY----------------IYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNK 367
L +R+ E +K+ + + ++ + L+ ++ + +
Sbjct: 1382 DDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQ 1441
Query: 368 DVKDTEKKLNKITKFIEENKEKFTQL----DLEDVQVREKLKHATSKAKKLEKQLQKDKE 423
+ EKK K + + E K + D + + REK A S A+ LE+ L+ +E
Sbjct: 1442 VASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE 1501
Query: 424 KVEEFKSIPAKSNNI----------INETTTRNNALEKEKEKEEKKLKEVMDSLK----- 468
+ K + A ++ ++E ALE++ E+ +L+E+ D L+
Sbjct: 1502 FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDA 1561
Query: 469 -------------QETQGLQKEKESREKELMGFSKSVNE-----------------ARSK 498
Q + LQ E E++ K V E ++ K
Sbjct: 1562 KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK 1621
Query: 499 MDVAQSELDIYLSRHNTA----VSQLTKAKEALIAASETLKERKAA-------------- 540
M++ +L+ + N A + QL K + + L+E +A+
Sbjct: 1622 MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKK 1681
Query: 541 IRDIEGKLPQTEQEL-------KEKEKELQKLTQEETN--------------FKSLVHDL 579
++ +E ++ Q ++EL + E+E +L E TN ++ + L
Sbjct: 1682 LKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQL 1741
Query: 580 FQKVEEAKSSLAMNRSR 596
+++EE +S++ + R
Sbjct: 1742 EEELEEEQSNMELLNDR 1758
Score = 60.5 bits (145), Expect = 1e-08
Identities = 84/383 (21%), Positives = 168/383 (43%), Gaps = 64/383 (16%)
Query: 788 KKAMQIQEQKVQLE---ERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEA 844
K +Q+ Q+ +L+ E ++K++ + ++ LE+ Q+L+E++ L Q+ + E
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL-QAET 900
Query: 845 NVLATAPDKKKQKLLEENVSAFKTEYDAVA-EKAGKVEAEVKRLHNTIVEINNHKLKAQQ 903
+ A A + + + ++A K E + + + +VE E +R N I++ K++A
Sbjct: 901 ELFAEAEEMRAR------LAAKKQELEEILHDLESRVEEEEER--NQILQNEKKKMQAH- 951
Query: 904 DKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELK 963
+ + +QLDE A K Q+ TA+ ++K ++ +L E + KE K
Sbjct: 952 --IQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK-------K 1002
Query: 964 SLEDKAAEVVKNTNAAEE---SLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLE- 1019
+ED+ AE EE +L +I+ + ++ +L+ + E +++ K KL+
Sbjct: 1003 LMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062
Query: 1020 ---QIDGHIAEHNSKIKYWHKEISK--------------ISLHPIEDNPIEEISVLS--- 1059
+ IAE ++I +++K +LH ++N ++ + L
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLH--KNNALKVVRELQAQI 1120
Query: 1060 ---PEDLE--------AIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVA 1108
ED E A K ++ ++ L+ + A E + K E Q VA
Sbjct: 1121 AELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE---QEVA 1177
Query: 1109 ELDKITYERDSFRQA-YEDLRKQ 1130
EL K E +A +D+R++
Sbjct: 1178 ELKKALEEETKNHEAQIQDMRQR 1200
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 110 bits (275), Expect = 9e-24
Identities = 158/849 (18%), Positives = 345/849 (40%), Gaps = 87/849 (10%)
Query: 289 KMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYI---YELQKRIAEMETQKEKIH 345
K +E++ L EKN + E + C I +L+ +I E+ + E
Sbjct: 875 KELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEE 934
Query: 346 EDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLK 405
E E+ K L +E KD+ D E L K+ K + K L E + E +
Sbjct: 935 EINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIA 994
Query: 406 HATSKAKKLEKQLQK--DKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEV 463
T + K L++ Q+ D ++EE K N L K K K E+++ ++
Sbjct: 995 KLTKEKKALQEAHQQTLDDLQMEEDKV----------------NTLTKAKTKLEQQVDDL 1038
Query: 464 MDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKA 523
SL+QE + L + E +++L G K E+ + + +L+ L + +S L
Sbjct: 1039 EGSLEQEKK-LCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGK 1097
Query: 524 KEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKV 583
E A + L+++ I++++ ++ + E+E++ + K ++ ++ + ++ +++
Sbjct: 1098 IEDEQALAIQLQKK---IKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154
Query: 584 EEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALD-- 641
EEA + + K +A Q+ + A+ +K+ +++ +D
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSL 1214
Query: 642 -----YIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMA-VWAKKMTEIQTPENTPRLFD 695
+ + ++ E + +KM +++EI+T E +
Sbjct: 1215 QRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQ--- 1271
Query: 696 LVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVT-----LQGQIIEQSGT 750
++ +E Q + LD+ + Q R + T L+ Q+ E++
Sbjct: 1272 --RLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKA 1329
Query: 751 MTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKA-------------------M 791
+ + R L+ E EEE + +++LQ KA
Sbjct: 1330 KSTLAHALQSARHDCDLLREQYEEE-QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTE 1388
Query: 792 QIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAP 851
+++E K +L +R+ + + + QRL + E L + V+ A +A
Sbjct: 1389 ELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIAL-- 1446
Query: 852 DKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINN-------------HK 898
KKQ+ ++ ++ +K +Y+ + + E + L + ++ N +
Sbjct: 1447 -DKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRE 1505
Query: 899 LKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDL 958
K Q ++ + +Q+ E I + + K D + Q S+ E ++ E ++ +
Sbjct: 1506 NKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRI 1565
Query: 959 TAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKL 1018
EL ++ +E+ + +E L ++++ H +++ ++ + E + DAL IK K+
Sbjct: 1566 QLELNQVK---SEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKM 1622
Query: 1019 EQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIAL 1078
E G + E ++ + +++ ++ + I + + L +D AI+ D + Q+A+
Sbjct: 1623 E---GDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDD--AIRGQDDLKEQLAM 1677
Query: 1079 LEARCHEMK 1087
+E R + M+
Sbjct: 1678 VERRANLMQ 1686
Score = 95.1 bits (235), Expect = 4e-19
Identities = 169/847 (19%), Positives = 356/847 (42%), Gaps = 90/847 (10%)
Query: 329 ELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKE 388
E +K +A M+ + EK E+ + K L +M ++ D + ++ + + +E
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEE 907
Query: 389 KFTQLDLEDVQVREKLKHATSKAKKLEK---QLQKDKEKVEEFKSIPAKSNNIINETTTR 445
+ QL +Q+ K+K T +A+ E+ +L K K+E+ S K + + T +
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 446 NNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSK-MDVAQS 504
+EKEK E K+K +L +E GL + KE K++ EA + +D Q
Sbjct: 968 ---VEKEKHATENKVK----NLTEEMAGLDETIAKLTKE----KKALQEAHQQTLDDLQM 1016
Query: 505 ELDIYLSRHNTAVSQLTKAKEALIAASETLKERKA-------AIRDIEGKLPQTEQELKE 557
E D + NT TK ++ + +L++ K A R +EG L ++ +
Sbjct: 1017 EED----KVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMD 1072
Query: 558 KEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQE-------KKSG 610
E + Q+L ++ + + +L K+E+ ++ + + K L A I+E +++
Sbjct: 1073 TENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERAS 1132
Query: 611 RIPGIYGRLG---DLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVAT 667
R R +L I E+ + A + ++ ++ +E R+++ +T
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIE------MNKKREAEFQKMRRDLEEST 1186
Query: 668 FIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRV 727
A KK + E ++ L +VK + ++ + +A N++ ++
Sbjct: 1187 LQHEATAAALRKKHAD-SVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKA 1245
Query: 728 AYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDS 787
++ R TL+ Q+ E + + R+ + L + + E Q D
Sbjct: 1246 KANFEKMCR--TLEDQLSEIK------TKEEEQQRLINELSAQKARLHTESGEFSRQLDE 1297
Query: 788 KKAM--QIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEAN 845
K AM Q+ K +++ +L+ E ++Q + L Q +E +
Sbjct: 1298 KDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQE- 1356
Query: 846 VLATAPDKKKQKLLEENVSAFKTEYDAVA-EKAGKVEAEVKRLHNTI------VEINNHK 898
A A ++ V+ ++T+Y+ A ++ ++E K+L + VE N K
Sbjct: 1357 --AKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414
Query: 899 LKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDL 958
+ + ++ ++++ + ++ A D+ + + +++ ++T+ E++
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEAS 1474
Query: 959 TAELKSLEDKAAEVVKNTNAAEESLPEIQ---KEHRNLLQELKVIQE-------NEHALQ 1008
E +SL + E+ K NA EESL ++ +E++NL QE+ + E + H L+
Sbjct: 1475 QKESRSL---STELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELE 1531
Query: 1009 KDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIE-DNPIEEISVLSPEDLEAIK 1067
K + + ++ + E + +++ +I +I L + + I+ E+L+ +K
Sbjct: 1532 KVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLK 1591
Query: 1068 NPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYE---RDSFRQAY 1124
N + ++E+ M+ L A + + L +++ E D E + RQA
Sbjct: 1592 R-----NHLRVVES----MQSTLDAEIR-SRNDALRIKKKMEGDLNEMEIQLNHANRQAA 1641
Query: 1125 EDLRKQR 1131
E LR R
Sbjct: 1642 EALRNLR 1648
Score = 94.4 bits (233), Expect = 6e-19
Identities = 213/1039 (20%), Positives = 416/1039 (40%), Gaps = 158/1039 (15%)
Query: 199 ISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMM-KPKGQTEHDEGMLEYLEDI 257
++ KK+ +D + L+ D+D + + E E+ A K K TE G
Sbjct: 940 LTAKKRKLEDECSELKK---DIDDLELTLAKVEKEKHATENKVKNLTEEMAG-------- 988
Query: 258 IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFR 317
L+E I L + + L E + L+ ++M E + + L K LE ++
Sbjct: 989 -----LDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKT------KLEQQVDD 1037
Query: 318 KKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLN 377
+ + Q +K ++E K K+ D K E + N+ + N+ +K E +++
Sbjct: 1038 LEGSLEQE-----KKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMS 1092
Query: 378 KITKFIEENKEKFTQLD--LEDVQVR-----EKLKHATSKAKKLEKQLQKDKEKVEEFKS 430
+ IE+ + QL ++++Q R E+++ + K EKQ ++EE
Sbjct: 1093 NLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISE 1152
Query: 431 IPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSK 490
++ + N E E +K + L+E + L+K+ EL
Sbjct: 1153 RLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQID 1212
Query: 491 SVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQ 550
S+ + K++ +SEL + ++ + + ++KAK TL+++ +
Sbjct: 1213 SLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLS----------- 1261
Query: 551 TEQELKEKEKELQKLTQEETNFKSLVH---DLFQKVEEAKSSLAMNRSRGKVLDAIIQEK 607
E+K KE+E Q+L E + K+ +H F + + K ++ SRGK A Q+
Sbjct: 1262 ---EIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGK--QAFTQQ- 1315
Query: 608 KSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVAT 667
+ +L E+ A S+ HAL D D+ +E + + Q
Sbjct: 1316 -----------IEELKRQLEEETKAKSTLAHALQSARHD-CDLLRE--QYEEEQEAKAEL 1361
Query: 668 FIGLDK----MAVWAKKMTEIQTPENTPRLFDLVK-----VKD---------------EK 703
G+ K +A W K E + T L + K ++D EK
Sbjct: 1362 QRGMSKANSEVAQWRTKY-ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEK 1420
Query: 704 IRQAFYFALRDTLVADNLDQATRVAYQKDRR--------WRVVTLQGQI-----IEQSGT 750
+Q + D ++ A +A K +R W+ + Q ++S +
Sbjct: 1421 TKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRS 1480
Query: 751 MTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHS 810
++ KV S +E + E ++ ++ + +++ + + +LE+ +L H
Sbjct: 1481 LSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHE 1540
Query: 811 EREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEY 870
+ E++ +LE+ AS++ E+ + L +Q LE N + + D+K + EE +
Sbjct: 1541 KSELQTSLEEAEASLEH--EEGKILRIQ---LELNQVKSEIDRKIAEKDEELDQLKRNHL 1595
Query: 871 DAVAEKAGKVEAEVKRLHNTIVEINNH---KLKAQQDKLDKINKQLDECASAITKAQVAI 927
V ++AE+ R N + I L + +L+ N+Q E + Q +
Sbjct: 1596 RVVESMQSTLDAEI-RSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGIL 1654
Query: 928 KTADRNLQKA---QD-------------------------SVLRTEKEIKDTEKEVDDLT 959
K +L A QD S+ RTE+ K E+E+ D +
Sbjct: 1655 KDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDAS 1714
Query: 960 AELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDA--LSIKLK 1017
++ L + ++ E + +IQ E +++QE + +E DA ++ +LK
Sbjct: 1715 ERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELK 1774
Query: 1018 LEQ-IDGHIAEHNSKIKYWHKEISKISLHPIEDNPI----EEISVLSP--EDLEAIKNPD 1070
EQ H+ ++ K++ ++ L E + ++I L +LE+ +
Sbjct: 1775 KEQDTSAHLERMKKNMEQTVKDL-QLRLDEAEQLALKGGKKQIQKLEARVRELESEVESE 1833
Query: 1071 SITNQIALLEARCHEMK-PNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRK 1129
N A+ R HE + L E +K L LQ + +DK+ + ++++ E+ +
Sbjct: 1834 QKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDL--VDKLQTKVKAYKRQAEEAEE 1891
Query: 1130 QRLNEFMAGFYIITNKLKE 1148
Q N +A F + ++L+E
Sbjct: 1892 QS-NVNLAKFRKLQHELEE 1909
Score = 87.8 bits (216), Expect = 6e-17
Identities = 152/774 (19%), Positives = 325/774 (41%), Gaps = 101/774 (13%)
Query: 283 EKLNRVKM-VEKEKDALEGEKNIA---IEFLTLENEIFRKKNHVCQYYIYEL-------Q 331
+ L RVK +EKEK L+ E N +E ++ F K + + E+ Q
Sbjct: 1212 DSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQ 1271
Query: 332 KRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFT 391
+ I E+ QK ++H ++ E S ++ K+ V + T+ IEE K +
Sbjct: 1272 RLINELSAQKARLHTESGEF-------SRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLE 1324
Query: 392 QLDLEDVQVREKLKHATSKAKK----LEKQLQKDKEKVEEFKSIPAKSNNIINETTT--- 444
E+ + + L HA A+ L +Q ++++E E + +K+N+ + + T
Sbjct: 1325 ----EETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYE 1380
Query: 445 -----RNNALEKEKEKEEKKLKEVMD----------SLKQETQGLQKEKE---------- 479
R LE+ K+K ++L++ + SL++ Q LQ E E
Sbjct: 1381 TDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSN 1440
Query: 480 ----SREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLK 535
+ +K+ F K + E + K + Q+EL+ + ++L K K A + + L+
Sbjct: 1441 AACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLE 1500
Query: 536 ERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRS 595
K ++++ ++ +++ E K + +L + + +L +EEA++SL
Sbjct: 1501 TLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASL--EHE 1558
Query: 596 RGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECV 655
GK+L + +L + + D I+ LD + + + + +
Sbjct: 1559 EGKILRIQL----------------ELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQ 1602
Query: 656 NFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIR--QAFYFALR 713
+ L + I A+ KK E E +L + E +R + L+
Sbjct: 1603 STLDAE-------IRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILK 1655
Query: 714 DTLVADNLDQATRVAYQKDRRWRVVTLQGQIIE-QSGTMTGGGSKVMKGR-MGSSLVIEI 771
DT + +LD A R + +V + +++ + + + +GR M +++
Sbjct: 1656 DTQL--HLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDA 1713
Query: 772 SE--EEVNKMESQLQNDSKK-AMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRL 828
SE + ++ + L N KK I + + ++E+ V + R++E + + + A +
Sbjct: 1714 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITD-AAMMAEE 1772
Query: 829 IEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLH 888
+++E+ + ++ ++ N+ T D Q L+E A + ++ K+EA V+ L
Sbjct: 1773 LKKEQDTSAHLERMKKNMEQTVKD--LQLRLDE---AEQLALKGGKKQIQKLEARVRELE 1827
Query: 889 NTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEI 948
+ + H ++A + L K +++ E + + I + K Q V +++
Sbjct: 1828 SEVESEQKHNVEAVKG-LRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQA 1886
Query: 949 KDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQE 1002
++ E++ + A+ + L+ + E + + AE + +++ + R + KVI E
Sbjct: 1887 EEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSREV--HTKVISE 1938
Score = 86.3 bits (212), Expect = 2e-16
Identities = 151/846 (17%), Positives = 339/846 (40%), Gaps = 93/846 (10%)
Query: 262 RLNEPIKVLCRRVEILNEH-RGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKN 320
+L + IK L R+E L E E+ +R K EK++ L E L +E +
Sbjct: 1107 QLQKKIKELQARIEELEEEIEAERASRAK-AEKQRSDLSRE-------LEEISERLEEAG 1158
Query: 321 HVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKIT 380
I +KR AE + + + E T + + L + ++ + L ++
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVK 1218
Query: 381 KFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIIN 440
+ +E+ K ++L +E + ++ + EK + ++++ E K+ + +IN
Sbjct: 1219 QKLEKEK---SELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLIN 1275
Query: 441 ETTTRNNALEKEKEKEEKKLKEVMDSLKQETQG----------LQKEKESREKELMGFSK 490
E + + L E + ++L E + Q ++G L+++ E K +
Sbjct: 1276 ELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAH 1335
Query: 491 SVNEARSKMDV----------AQSELDIYLSRHNTAVSQL-TKAKEALIAASETLKERKA 539
++ AR D+ A++EL +S+ N+ V+Q TK + I +E L+E K
Sbjct: 1336 ALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAK- 1394
Query: 540 AIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKV 599
+ + +L E+ ++ + L + + ++ V DL VE + ++ + +
Sbjct: 1395 --KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRN 1452
Query: 600 LDAIIQEKKS------GRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQE 653
D ++ E K + L K A L+ + ++ ++ QE
Sbjct: 1453 FDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQE 1512
Query: 654 CVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALR 713
+ ++ G L+K+ KK + + E L + + + + L
Sbjct: 1513 ISDLTEQIAEGGKHIHELEKV----KKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLE 1568
Query: 714 DTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISE 773
V +D+ ++A + + ++ +++E +M ++ R + + + E
Sbjct: 1569 LNQVKSEIDR--KIAEKDEELDQLKRNHLRVVE---SMQSTLDAEIRSRNDALRIKKKME 1623
Query: 774 EEVNKMESQLQNDSKKAMQ----------------------------IQEQKVQLEERVV 805
++N+ME QL + +++A + ++EQ +E R
Sbjct: 1624 GDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRAN 1683
Query: 806 KLRHSEREMRNTLEKFTASIQRLIEQEEY-LNVQVKELEANVLATAPDKKKQKLLEENVS 864
++ E+R +LE+ T +++ EQE + +V+ L + KKK LE ++S
Sbjct: 1684 LMQAEVEELRASLER-TERGRKMAEQELLDASERVQLLHTQNTSLINTKKK---LETDIS 1739
Query: 865 AFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDK---LDKINKQLDECASAIT 921
+ E + + ++A E + K+ T + +LK +QD L+++ K +++ +
Sbjct: 1740 QIQGEMEDIVQEARNAEEKAKKAI-TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQ 1798
Query: 922 -----KAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNT 976
Q+A+K + +QK + V E E++ +K + L+ E + E+ T
Sbjct: 1799 LRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQT 1858
Query: 977 NAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWH 1036
+++ +Q L ++K + ++ + K ++ + E +
Sbjct: 1859 EEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAE 1918
Query: 1037 KEISKI 1042
+++K+
Sbjct: 1919 SQVNKL 1924
Score = 68.2 bits (165), Expect = 5e-11
Identities = 132/704 (18%), Positives = 273/704 (38%), Gaps = 101/704 (14%)
Query: 410 KAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSL-- 467
K+ + EK++ KE+ E+ K AK+ E + L +EK + +++ D+L
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALAD 904
Query: 468 -----------KQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTA 516
K + + KE R ++ + + + K++ SEL +
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 964
Query: 517 VSQLTKAKEALIAASETLKERKAAIRDIEGKL-----------PQTEQELKEKEKELQKL 565
++++ K K A + L E A + + KL QT +L+ +E ++ L
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTL 1024
Query: 566 TQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGK-VLDAIIQ------------------- 605
T+ +T + V DL +E+ K L M+ R K L+ ++
Sbjct: 1025 TKAKTKLEQQVDDLEGSLEQEK-KLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEK 1083
Query: 606 -EKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIG 664
+KK + + G++ D A+ + I ++ + +I E + K +
Sbjct: 1084 LKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEEL---EEEIEAERASRAKAEK-- 1138
Query: 665 VATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLD-Q 723
+ + ++++ EI +++ K R+A + +R L L +
Sbjct: 1139 --------QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHE 1190
Query: 724 ATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISE--EEVNKMES 781
AT A +K V L QI R+ L E SE E+N + S
Sbjct: 1191 ATAAALRKKHADSVAELGEQIDSLQ-------------RVKQKLEKEKSELKMEINDLAS 1237
Query: 782 QLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKE 841
++ SK ++ LE+++ +++ E E + + + +A RL + + Q+ E
Sbjct: 1238 NMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDE 1297
Query: 842 LEANVLATAPDKKK--------QKLLEENVSAFKTEYDAVA-------------EKAGKV 880
+A V + K+ ++ LEE A T A+ E+ +
Sbjct: 1298 KDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEA 1357
Query: 881 EAEVKR-LHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQD 939
+AE++R + E+ + K + D + ++ +E A K ++ A+ +++
Sbjct: 1358 KAELQRGMSKANSEVAQWRTKYETDAI----QRTEELEEAKKKLAQRLQDAEEHVEAVNS 1413
Query: 940 SVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKV 999
EK + + EV+DL +++ + K ++ L E ++++ EL+
Sbjct: 1414 KCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEA 1473
Query: 1000 IQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKIS 1043
Q+ +L + +K E+ H+ + K +EIS ++
Sbjct: 1474 SQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLT 1517
Score = 64.7 bits (156), Expect = 5e-10
Identities = 125/694 (18%), Positives = 271/694 (39%), Gaps = 116/694 (16%)
Query: 216 HGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIG-CGRLNEPIKVLCRRV 274
H DL ++ Q ++ K +E + +Y D I L E K L +R+
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401
Query: 275 EILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRI 334
+ EH ++ +EK K L+ E +E L ++ E + N C + + Q+
Sbjct: 1402 QDAEEHVEAVNSKCASLEKTKQRLQNE----VEDLMIDVE---RSNAAC-IALDKKQRNF 1453
Query: 335 AEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLD 394
++ + ++ +E+T+ E++A K+ + +L K+ EE+ + L
Sbjct: 1454 DKVLAEWKQKYEETQA----------ELEASQKESRSLSTELFKVKNAYEESLDHLETLK 1503
Query: 395 LEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKE 454
E+ +++++ T + + K + + LEK K+
Sbjct: 1504 RENKNLQQEISDLTEQIAEGGKHIHE----------------------------LEKVKK 1535
Query: 455 KEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHN 514
+ + + E+ SL++ L+ E E +++ +N+ +S++D +E D L +
Sbjct: 1536 QLDHEKSELQTSLEEAEASLEHE----EGKILRIQLELNQVKSEIDRKIAEKDEELDQLK 1591
Query: 515 TAVSQLTKAKEALIAASETLKERKAAIR---DIEGKLPQTEQELKEKEKELQKLTQEETN 571
++ ++ ++ + A ++ R A+R +EG L + E +L ++ + + N
Sbjct: 1592 RNHLRVVESMQSTLDAE--IRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRN 1649
Query: 572 FKSLVHDLFQKVEEA-------KSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGR-LGDLG 623
+ ++ D +++A K LAM R ++ A ++E ++ GR + +
Sbjct: 1650 TQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQE 1709
Query: 624 AIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTE 683
+D A E V L QN + + KK E
Sbjct: 1710 LLD------------------------ASERVQLLHTQNTSL----------INTKKKLE 1735
Query: 684 IQTPENTPRLFDLV---KVKDEKIRQAFYFA--LRDTLVADNLDQATRVAYQKDRRWRVV 738
+ + D+V + +EK ++A A + + L + A +K+ V
Sbjct: 1736 TDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1795
Query: 739 TLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKV 798
LQ ++ E GG K I+ E V ++ES+++++ K ++ +
Sbjct: 1796 DLQLRLDEAEQLALKGGKK----------QIQKLEARVRELESEVESEQKHNVEAVKGLR 1845
Query: 799 QLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKL 858
+ E RV +L + E R + + + +L + + Q +E E + + K +
Sbjct: 1846 KHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQ---SNVNLAKFRK 1902
Query: 859 LEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIV 892
L+ + K D + K+ + + +H ++
Sbjct: 1903 LQHELEEAKERADIAESQVNKLRVKSREVHTKVI 1936
Score = 55.1 bits (131), Expect = 4e-07
Identities = 46/224 (20%), Positives = 106/224 (47%), Gaps = 22/224 (9%)
Query: 804 VVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENV 863
++K +E+EM N E+F + + L + E + KELE ++ +K +L
Sbjct: 843 LLKSAETEKEMANMKEEFEKTKEELAKTE----AKRKELEEKMVTLMQEKNDLQL----- 893
Query: 864 SAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKA 923
+ E DA+A+ + + +K +I +A+ + ++IN +L + K
Sbjct: 894 -QVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDE--EEINAEL---TAKKRKL 947
Query: 924 QVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESL 983
+ +++ + ++ + EKE TE +V +LT E+ L++ A++ K A
Sbjct: 948 EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKA----- 1002
Query: 984 PEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAE 1027
+Q+ H+ L +L++ ++ + L K ++ +++ ++G + +
Sbjct: 1003 --LQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQ 1044
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 108 bits (271), Expect = 3e-23
Identities = 173/842 (20%), Positives = 348/842 (41%), Gaps = 124/842 (14%)
Query: 288 VKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHED 347
+ ++EKE++ L + + N++ ++KNH Q + +L +++ + Q E +
Sbjct: 539 ISLLEKEREDLYAKIQAGEGETAVLNQL-QEKNHTLQEQVTQLTEKL---KNQSESHKQA 594
Query: 348 TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHA 407
+ ++++ ++A V E +N++ + E+KEK +QLD++ E L A
Sbjct: 595 QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSA 654
Query: 408 TSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEE---------K 458
+ LQ + + ++ K + TT + K ++K+E K
Sbjct: 655 EAAKTAQRADLQNHLDTAQ--NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLK 712
Query: 459 KLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVS 518
+ KE SL+Q+T+ L+ + + E + + S +A + Q +L+ L T +S
Sbjct: 713 EYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQ-QQRQLNTDLELRATELS 771
Query: 519 -QLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVH 577
QL KE + + L+++ A+ I+ KL + E+E + +++ + L+QE K
Sbjct: 772 KQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET---KIQHE 828
Query: 578 DLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCC 637
+L +++ + L + + L + +L + +K
Sbjct: 829 ELNNRIQTTVTELQKVKMEKEAL------------------MTELSTVKDKLSK------ 864
Query: 638 HALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLV 697
V DS+ ++ F K G A + L+K K ++Q +L
Sbjct: 865 ------VSDSLKNSKS--EFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916
Query: 698 KVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQI--IEQSGTMTGGG 755
K +++ + L + + L QA Q ++ + LQG I ++QS
Sbjct: 917 KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ--QLQGNINELKQSSEQKKKQ 974
Query: 756 SKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMR 815
+ ++G + +++ +++L+N ++Q+Q Q + + + ++
Sbjct: 975 IEALQGELKIAVL----------QKTELEN------KLQQQLTQAAQELAAEKEKISVLQ 1018
Query: 816 NTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAE 875
N EK + ++L Q ++ E+ +LAT D K +EE +S + D ++
Sbjct: 1019 NNYEKSQETFKQL--QSDFYG-----RESELLATRQDLKS---VEEKLSL--AQEDLISN 1066
Query: 876 KAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQ 935
+ ++ + I E+ K +QD K +QL E A+ Q ++ L
Sbjct: 1067 R-----NQIGNQNKLIQELKTAKATLEQDSAKK-EQQLQERCKALQDIQKEKSLKEKELV 1120
Query: 936 KAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQ 995
+ + E+ EKE+ L ELKS + ++ + + N A++ L + + E +
Sbjct: 1121 NEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKAD 1180
Query: 996 ELKVIQENEHALQ---KDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPI 1052
LK E E Q KD +K + E++ E +K+ H EI +
Sbjct: 1181 SLKAAVEQEKRNQQILKD--QVKKEEEELKKEFIEKEAKL---HSEIKE----------- 1224
Query: 1053 EEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDK 1112
+E+ + E+ EA +T QI L NLG + KK+ + +RV+EL+K
Sbjct: 1225 KEVGMKKHEENEA-----KLTMQITAL-------NENLGTV---KKEWQSSQRRVSELEK 1269
Query: 1113 IT 1114
T
Sbjct: 1270 QT 1271
Score = 100 bits (250), Expect = 7e-21
Identities = 183/909 (20%), Positives = 342/909 (37%), Gaps = 141/909 (15%)
Query: 262 RLNEPIKVLCRRVEILNEHRGEK-LNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKN 320
+L + L ++ + L E+ +K + K+ EK + +KNI +K+
Sbjct: 292 KLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNI--------QATLHQKD 343
Query: 321 HVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKIT 380
CQ +LQ R++ ET +IH + E E + L E+ + + + ++
Sbjct: 344 LDCQ----QLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399
Query: 381 KFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIIN 440
+ EE ++ QL E Q+ KL + + +L++ ++ E + +
Sbjct: 400 QQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQ 459
Query: 441 ETTTRNNALEKEKEKEEKKLKEVMDSLK---QETQGLQKEKESREKELMGFSKSVNEARS 497
+R KEK +L+ +D K QE Q LQ+ ++ +E + V
Sbjct: 460 LKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG 519
Query: 498 KMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKE 557
D L+ L + +S L K +E L A + + A + ++ K L+E
Sbjct: 520 DKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEK----NHTLQE 575
Query: 558 KEKEL-QKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIY 616
+ +L +KL + + K +L +V+E K+ L + R L+ + E S
Sbjct: 576 QVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNS------- 628
Query: 617 GRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAV 676
L EK V +DI I T + L A
Sbjct: 629 ----QLNESKEK----------------VSQLDI-----------QIKAKTELLLSAEAA 657
Query: 677 WAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWR 736
+ ++Q +T + + ++ K +++ + + LDQ T A +D++
Sbjct: 658 KTAQRADLQNHLDTAQ--NALQDKQQELNK----------ITTQLDQVT--AKLQDKQEH 703
Query: 737 VVTLQGQIIEQSGTMTGGGSKV------MKGRMGSSLVIEISEEE-VNKMESQLQNDSKK 789
L+ + E K +K SL ++ S+E+ + ++ Q Q ++
Sbjct: 704 CSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL 763
Query: 790 AMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEE--------------YL 835
++ E QLE + + +++ E + Q+L +QEE
Sbjct: 764 ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET 823
Query: 836 NVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEIN 895
+Q +EL + T + +K K+ +E A TE V +K KV +K + E
Sbjct: 824 KIQHEELNNRIQTTVTELQKVKMEKE---ALMTELSTVKDKLSKVSDSLKNSKSEF-EKE 879
Query: 896 NHKLKAQQDKLDKINKQL---------------DECASAITKAQVAIKTADRNLQKAQDS 940
N K KA L+K K+L E ++ K + A L Q+
Sbjct: 880 NQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ 939
Query: 941 VLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLP-----------EIQKE 989
+++ + +K EKE L + L+ + + K A + L ++Q++
Sbjct: 940 LIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ 999
Query: 990 HRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIED 1049
QEL +E LQ + + +Q+ S++ +++
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKS-------- 1051
Query: 1050 NPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQ-RVA 1108
+EE L+ EDL I N + I NQ L++ E+K + + K+E LQ R
Sbjct: 1052 --VEEKLSLAQEDL--ISNRNQIGNQNKLIQ----ELKTAKATLEQDSAKKEQQLQERCK 1103
Query: 1109 ELDKITYER 1117
L I E+
Sbjct: 1104 ALQDIQKEK 1112
Score = 100 bits (249), Expect = 9e-21
Identities = 145/794 (18%), Positives = 327/794 (41%), Gaps = 116/794 (14%)
Query: 292 EKEKDALEGE-KNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKE 350
E+E + L+ E K + ++ + E I + ++ + + + +A + +K+ E
Sbjct: 245 ERESEKLKDECKKLQSQYASSEATISQLRSELAKG-----PQEVAVYVQELQKLKSSVNE 299
Query: 351 INEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSK 410
+ +K+ L+ + K +D E+K N+ + + + Q DL+ Q++ +L + +
Sbjct: 300 LTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETS 359
Query: 411 AKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQE 470
++ +L + E ++ K E+ E E K LK E
Sbjct: 360 LHRIHVELSEKGEATQKLK--------------------EELSEVETK-----YQHLKAE 394
Query: 471 TQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAA 530
+ LQ+++E +E+ + +N+ SK+ + +L H + KE +
Sbjct: 395 FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLG---EAHG-------RLKEQRQLS 444
Query: 531 SETLKERKAAIRDIEGKLPQTEQELKEK-------EKELQKLTQEETNFKSLVHDLFQKV 583
SE L +++ + D++ KL + E++LKEK + +L K Q+ ++L K+
Sbjct: 445 SEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKL 504
Query: 584 EEAKSSLAM-------NRSRGKVLDAIIQEKKS-------------GRIPGIYGRLGDLG 623
EA++ L + + L+A++Q+ K +I G L
Sbjct: 505 REAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLN 564
Query: 624 AIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTE 683
+ EK H L V + + K+ + + K + A +
Sbjct: 565 QLQEKN--------HTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616
Query: 684 IQTPENTPRLFDLVKVKDEKIRQA-FYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQG 742
+ + L + EK+ Q + L+ +A + A + D + + T Q
Sbjct: 617 LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS--AEAAKTAQRADLQNHLDTAQN 674
Query: 743 QIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEE 802
+ ++ + +K+ + ++ +E +++ES L+ +K + ++++ +LE
Sbjct: 675 ALQDKQQEL----NKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG 730
Query: 803 RVVKLR-----------------HSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEAN 845
++ KL +R++ LE + + +E E+ + V L+
Sbjct: 731 QIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEI-VSSTRLDLQ 789
Query: 846 VLATAPDKKKQKLL--EENVSAFKTEYDAVAEKAGKVEAEV--KRLHNTIVEINNHKLKA 901
+ A + KQKL EE K +++ ++++ K++ E R+ T+ E+ K++
Sbjct: 790 KKSEALESIKQKLTKQEEEKQILKQDFETLSQET-KIQHEELNNRIQTTVTELQKVKMEK 848
Query: 902 Q---------QDKLDKINKQLDECASAITKAQVAIKTADRNLQK-AQDSVLRTEKEIKDT 951
+ +DKL K++ L S K K A +L+K ++ + + ++++T
Sbjct: 849 EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENT 908
Query: 952 EKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDA 1011
KE +L L+ ++ + ++ N+ +E L + Q + +E + +Q N + L++ +
Sbjct: 909 LKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSS 968
Query: 1012 LSIKLKLEQIDGHI 1025
K ++E + G +
Sbjct: 969 EQKKKQIEALQGEL 982
Score = 94.7 bits (234), Expect = 5e-19
Identities = 137/625 (21%), Positives = 278/625 (44%), Gaps = 58/625 (9%)
Query: 262 RLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDAL---EGEKNIA---IEFLTLENEI 315
R E K L EI++ R + + + +E K L E EK I E L+ E +I
Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKI 825
Query: 316 FRKK-NHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEK 374
++ N+ Q + ELQK ++ +KE + + + +K + +S+ +K
Sbjct: 826 QHEELNNRIQTTVTELQK----VKMEKEALMTELSTVKDKLSKVSDSLK----------- 870
Query: 375 KLNKITKFIEEN-KEKFTQLDLEDV------QVREKLKHATSKAKKLEKQLQKDKEKVEE 427
N ++F +EN K K LDLE Q++ ++++ + K+L+K L+K+KE +
Sbjct: 871 --NSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQ 928
Query: 428 FKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMG 487
K + N++ + N L K+ EKEE++L+ ++ LKQ ++ +K+ E+ + EL
Sbjct: 929 LK---LELNSMQEQLIQAQNTL-KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKI 984
Query: 488 FSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGK 547
E +K+ ++ L+ +S L E + ET K+ ++ E +
Sbjct: 985 AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYE---KSQETFKQLQSDFYGRESE 1041
Query: 548 LPQTEQELKEKEKELQKLTQEETNFKSLV---HDLFQKVEEAKSSLAMN--------RSR 596
L T Q+LK E++L ++ + ++ + + L Q+++ AK++L + + R
Sbjct: 1042 LLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQER 1101
Query: 597 GKVLDAIIQEK--KSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQEC 654
K L I +EK K + +L ++ I + + I+ L ++SI +E
Sbjct: 1102 CKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESI---KEI 1158
Query: 655 VNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRD 714
N + + + + L A K E Q N L D VK ++E++++ F
Sbjct: 1159 TNLKDAKQLLIQQKLELQGKADSLKAAVE-QEKRNQQILKDQVKKEEEELKKEF-IEKEA 1216
Query: 715 TLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEE 774
L ++ ++ + ++ ++ + E GT+ + +
Sbjct: 1217 KLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRG 1276
Query: 775 EVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEY 834
E+ +E+ +QN+ + + E+ ++ E + KL+ E++ L+ TA++Q L + +
Sbjct: 1277 EIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQ- 1335
Query: 835 LNVQVKELEANVLATAPDKKKQKLL 859
++Q+K +A A D + Q +
Sbjct: 1336 -SLQIKHTQALNRKWAEDNEVQNCM 1359
Score = 93.6 bits (231), Expect = 1e-18
Identities = 170/850 (20%), Positives = 338/850 (39%), Gaps = 157/850 (18%)
Query: 289 KMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHV--CQYYIYELQKRIAEMETQ----KE 342
++ EK K+ E K L +++ +K H+ Q + L+ + E+ +Q KE
Sbjct: 579 QLTEKLKNQSESHKQAQEN---LHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKE 635
Query: 343 KIHEDTKEINEKSNIL--------------SNEMKAKNKDVKDTEKKLNKITKFIEE--- 385
K+ + +I K+ +L N + ++D +++LNKIT +++
Sbjct: 636 KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTA 695
Query: 386 ----NKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINE 441
+E +QL+ + +EK K ++LE Q++K + E K+ ++ + +
Sbjct: 696 KLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQ 755
Query: 442 TTTRNNALE-------KEKEKEEK----------KLKEVMDSLKQETQGLQKEKESREKE 484
N LE K+ E E++ K E ++S+KQ+ ++EK+ +++
Sbjct: 756 QRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQD 815
Query: 485 LMGFSKSVN----EARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERK-- 538
S+ E +++ +EL +++L+ K+ L S++LK K
Sbjct: 816 FETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE 875
Query: 539 ---------AAIRDIEG-----------KLPQTEQELKEKEKELQKLTQEETNFKSLVHD 578
AAI D+E ++ T +E KE +K L+K + K ++
Sbjct: 876 FEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNS 935
Query: 579 LFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCH 638
+ +++ +A+++L N + L I E K E+ I +
Sbjct: 936 MQEQLIQAQNTLKQNEKEEQQLQGNINELKQS---------------SEQKKKQIEALQG 980
Query: 639 ALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTP-ENTPRLFDLV 697
L V+ ++ N L++Q A + +K +K++ +Q E + F +
Sbjct: 981 ELKIAVLQKTELE----NKLQQQLTQAAQELAAEK-----EKISVLQNNYEKSQETFKQL 1031
Query: 698 KVKDEKIRQAFYFALRDTL--VADNLDQATRVAYQKDRRWRVVTLQGQIIEQ----SGTM 751
+ D R++ A R L V + L A + + Q ++I++ T+
Sbjct: 1032 Q-SDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQ---IGNQNKLIQELKTAKATL 1087
Query: 752 TGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSE 811
+K + ++ ++E + E +L N+ K +I+E K + E+ + KL
Sbjct: 1088 EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL 1147
Query: 812 R----EMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFK 867
+ E + + Q LI+Q+ L + L+A A +K+ Q++L++ V +
Sbjct: 1148 KSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKA---AVEQEKRNQQILKDQVKKEE 1204
Query: 868 TEYDA-VAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVA 926
E EK K+ +E+K E+ K + + KL +
Sbjct: 1205 EELKKEFIEKEAKLHSEIKEK-----EVGMKKHEENEAKLT-----------------MQ 1242
Query: 927 IKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEI 986
I + NL + +++ + + EK+ DDL E+ LE A V N
Sbjct: 1243 ITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLE---ATVQNN----------- 1288
Query: 987 QKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAE---HNSKIKYWHKEISKIS 1043
Q E R LL+ + LQ L ++ KL+ + E N ++ H + ++
Sbjct: 1289 QDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQ--ALN 1346
Query: 1044 LHPIEDNPIE 1053
EDN ++
Sbjct: 1347 RKWAEDNEVQ 1356
Score = 72.8 bits (177), Expect = 2e-12
Identities = 137/644 (21%), Positives = 274/644 (42%), Gaps = 96/644 (14%)
Query: 541 IRDIEGKLPQTEQELKEKEKELQK---LTQEETNFKSLVHD-------LFQKVEEAKSSL 590
++D++ L + + +E +KEL+K L Q+E LV D L Q++EEA++
Sbjct: 92 VQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTE- 150
Query: 591 AMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDI 650
N + ++ D E+K+ ++ ++ I KYD S A + V +
Sbjct: 151 --NFNIKQMKDLF--EQKAAQLAT------EIADIKSKYDEE-RSLREAAEQKVTRLTEE 199
Query: 651 AQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYF 710
+ ++ + G++ +AV K++ ++QT
Sbjct: 200 LNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQT------------------------ 235
Query: 711 ALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIE 770
L D + + ++ ++ + + LQ Q T++ S++ KG ++ ++
Sbjct: 236 -LMDNMTLERERESEKLKDECKK------LQSQYASSEATISQLRSELAKGPQEVAVYVQ 288
Query: 771 ISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIE 830
E+ K++S + ++K + E ++ E+ KL E ++ K +IQ +
Sbjct: 289 ----ELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNE--ESVSK--KNIQATLH 340
Query: 831 QEEYLNVQVKELEANVLATAPDKKKQKLLE--ENVSAFKTEYDAVAEKAGKVEAEVKRLH 888
Q++ L+ Q + + T+ + +L E E K E V K ++AE K+L
Sbjct: 341 QKD-LDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQ 399
Query: 889 NTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEI 948
E H L+ Q + +++++ +L E + +A +K + L +EK +
Sbjct: 400 QQREEKEQHGLQLQSE-INQLHSKLLETERQLGEAHGRLK---------EQRQLSSEK-L 448
Query: 949 KDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQ 1008
D E++V DL +L LE++ E V N+ + L + +++H QE + +Q++ A
Sbjct: 449 MDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQH----QEQQALQQSTTAKL 504
Query: 1009 KDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSP--EDLEA- 1065
++A + LEQ+ I + + KI+ +L + E IS+L EDL A
Sbjct: 505 REAQN---DLEQVLRQIGDKDQKIQ---------NLEALLQKSKENISLLEKEREDLYAK 552
Query: 1066 IKNPDSITNQIALLEARCHEMKPNLGAIAE-YKKKEELYLQRVAELDKITYERDSFRQAY 1124
I+ + T + L+ + H ++ + + E K + E + Q L E+ + +A
Sbjct: 553 IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAA 612
Query: 1125 EDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLD 1168
+D R L + N+ KE L + A+ EL+ S +
Sbjct: 613 QD-RVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAE 655
Score = 69.3 bits (168), Expect = 2e-11
Identities = 161/896 (17%), Positives = 358/896 (39%), Gaps = 155/896 (17%)
Query: 300 GEKNIAIE-----FLTLENEIFRKKNHVCQYYIYELQKRIAEME-TQKEKIHEDTKEINE 353
GE N+A++ L E + + ++Y EL+K + + + Q+++ D +
Sbjct: 74 GESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS 133
Query: 354 KSNILSNEMKAKN--------KDVKDT-EKKLNKITKFIEENKEKFTQLDLEDVQVREKL 404
+ + S E + + K +KD E+K ++ I + K K+ E+ +RE
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYD----EERSLREA- 188
Query: 405 KHATSKAKKLEKQLQKDKEKVEEFKS-----------IPAKSNNIINETTTRNNALEKEK 453
A K +L ++L K+ +++ K+ K + +T N LE+E+
Sbjct: 189 --AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 246
Query: 454 EKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRH 513
E E+ LK E + LQ + S E ++++ RS++ E+ +Y+
Sbjct: 247 ESEK---------LKDECKKLQSQYASSEA-------TISQLRSELAKGPQEVAVYVQE- 289
Query: 514 NTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFK 573
+ +L + L ++TL E L + EQ+ + E++ + + + N +
Sbjct: 290 ---LQKLKSSVNELTQKNQTLTEN----------LLKKEQDYTKLEEKHNEESVSKKNIQ 336
Query: 574 SLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAI 633
+ +H ++ +S L+ + + + I+ L + G +K +
Sbjct: 337 ATLHQKDLDCQQLQSRLSASETS---------------LHRIHVELSEKGEATQKLKEEL 381
Query: 634 SSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRL 693
S ++ + + Q+ +++ G+ ++++ + TE Q E RL
Sbjct: 382 SEVETKYQHLKAEFKQLQQQRE---EKEQHGLQLQSEINQLHSKLLE-TERQLGEAHGRL 437
Query: 694 FDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQ-KDRRWRVVTLQGQII------- 745
+ ++ EK+ ++ VAD + +R+ Q K++ LQ Q+
Sbjct: 438 KEQRQLSSEKLMD------KEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQ 491
Query: 746 EQSGTMTGGGSKVMKGRMGSSLVIEI---SEEEVNKMESQLQNDSKKAMQIQEQKVQLEE 802
EQ +K+ + + V+ ++++ +E+ LQ + +++++ E+
Sbjct: 492 EQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKER---ED 548
Query: 803 RVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKK-QKLLEE 861
K++ E E TA + +L E+ L QV +L + + K+ Q+ L +
Sbjct: 549 LYAKIQAGEGE--------TAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHD 600
Query: 862 NVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAIT 921
V K A ++ +E V L N +L ++K+ +++ Q+ +
Sbjct: 601 QVQEQKAHLRAAQDRVLSLETSVNEL--------NSQLNESKEKVSQLDIQIKAKTELLL 652
Query: 922 KAQVAIKTADR-----NLQKAQDSVLRTEKEIKDTEKEVDDLTAELK------------- 963
A+ A KTA R +L AQ+++ ++E+ ++D +TA+L+
Sbjct: 653 SAEAA-KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHL 711
Query: 964 --------SLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIK 1015
SLE K E+ E E++ LQ+L+ ++ L+ A +
Sbjct: 712 KEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELS 771
Query: 1016 LKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQ 1075
+LE ++ ++ + + I + EE + +D E + I +
Sbjct: 772 KQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQ---EEEKQILKQDFETLSQETKIQH- 827
Query: 1076 IALLEARCHEMKPNLGAIAEYKKKEELYLQRVAEL-DKITYERDSFRQAYEDLRKQ 1130
E + ++ + + + K ++E + ++ + DK++ DS + + + K+
Sbjct: 828 ----EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKE 879
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 108 bits (269), Expect = 4e-23
Identities = 183/868 (21%), Positives = 377/868 (43%), Gaps = 107/868 (12%)
Query: 329 ELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKE 388
E +K +A M+ E+ E+ + L +M + ++ D + ++ T+ + + +E
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEE 907
Query: 389 KFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNI---INETTTR 445
+ L + + K+K T ++LE++ + + E V + +++ K +++ I++
Sbjct: 908 RCEGLIKSKILLEAKVKELT---ERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELT 964
Query: 446 NNALEKEKEKEEKKLK---EVMDSLKQETQGLQKEKESREK-------ELMGFSKSVN-- 493
+EKEK E K+K E M +L++ L KEK+S ++ +L VN
Sbjct: 965 LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGL 1024
Query: 494 -EARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTE 552
+ +K++ +L+ L + + L +AK L LK + +I D+E Q E
Sbjct: 1025 IKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKL---EGDLKMSQESIMDLENDKQQIE 1081
Query: 553 QELKEKEKELQKLTQE-------ETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQ 605
++LK+KE EL +L + F+ + +L ++EE + + + L A I+
Sbjct: 1082 EKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHT----LRAKIE 1137
Query: 606 EKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGV 665
+++S +L I E+ + A + ++ ++ +E R+++
Sbjct: 1138 KQRSDLAR-------ELEEISERLEEASGATSAQIE------MNKKREAEFQKMRRDLEE 1184
Query: 666 ATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQAT 725
AT A KK + E ++ +L +VK + ++ + +A N++ +
Sbjct: 1185 ATLQHEATAATLRKKQAD-SVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALS 1243
Query: 726 RVAYQKDRRWRVVTLQGQII---EQSGTMTGGGSKVMKGRMGSSLVIEISE--EEVNKME 780
+ +R R V Q I ++ T + K R+ + E+S EE +
Sbjct: 1244 KSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNG-ELSHRVEEKESLI 1302
Query: 781 SQLQNDSKKAM--QIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQ 838
SQL SK+A+ Q++E K Q+EE ++ M + L+ L EQ E
Sbjct: 1303 SQLTK-SKQALTQQLEELKRQMEEET----KAKNAMAHALQSSRHDCDLLREQYE----- 1352
Query: 839 VKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA-EKAGKVEAEVKRLHNTIVEIN-- 895
+E EA A ++ V+ ++T+Y+ A ++ ++E K+L + E
Sbjct: 1353 -EEQEAK----AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEN 1407
Query: 896 ----NHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVL--------R 943
N K + + ++ ++++ + ++ A T D+ Q+ D VL
Sbjct: 1408 TETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKK-QRNFDKVLAEWKQKLDE 1466
Query: 944 TEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQEL----KV 999
++ E++ +KE L+ EL + + EVV +Q+E +L +++ K
Sbjct: 1467 SQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKN 1526
Query: 1000 IQENEHA---LQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLH----PIE-DNP 1051
+QE E ++++ +++ LE+++G + SKI E+S++ IE D
Sbjct: 1527 LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEE 1586
Query: 1052 IEEI---SVLSPEDLEAIKNPDSITNQIAL-----LEARCHEMKPNLGAIAEYKKKEELY 1103
IE++ S + E L+++ + + + AL +E +EM+ LG + + +
Sbjct: 1587 IEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKH 1646
Query: 1104 LQRV-AELDKITYERDSFRQAYEDLRKQ 1130
L+ V +L D ++ EDL++Q
Sbjct: 1647 LRTVQGQLKDSQLHLDDALRSNEDLKEQ 1674
Score = 96.7 bits (239), Expect = 1e-19
Identities = 182/936 (19%), Positives = 389/936 (41%), Gaps = 155/936 (16%)
Query: 284 KLNRVKMVEKEKDALEGEKNIA---IEFLTLENEIFRKKNHVCQYY--IYELQKRIAEME 338
K+++ +++ E D + E+ + E L+ +I ++ H Q+ I ELQ RI E+E
Sbjct: 1064 KMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELE 1123
Query: 339 TQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQL--DLE 396
+ E H +I ++ + L+ E++ ++ +++ + + ++ + +F ++ DLE
Sbjct: 1124 EEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLE 1183
Query: 397 DVQVREKLKHATSKAKKLEK---------QLQKDKEKVEEFKSIPAKSNNIINETTTRNN 447
+ ++ + AT + K+ + LQ+ K+K+E+ KS + I++ +
Sbjct: 1184 EATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKS---ELKMEIDDMASNIE 1240
Query: 448 ALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELD 507
AL K K E+ + V D + K K+ ++ +L+ +N ++++ EL
Sbjct: 1241 ALSKSKSNIERTCRTVEDQFSEI-----KAKDEQQTQLI---HDLNMQKARLQTQNGELS 1292
Query: 508 IYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQ 567
+ + +SQLTK+K+AL E LK Q E+E K K L Q
Sbjct: 1293 HRVEEKESLISQLTKSKQALTQQLEELKR-------------QMEEETKAKNAMAHAL-Q 1338
Query: 568 EETNFKSLVHDLFQKVEEAKSSL--AMNRSRGKVL--------DAIIQEKKSGRIPGIYG 617
+ L+ + +++ +EAK+ L A++++ +V DAI +++ +
Sbjct: 1339 SSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAI---QRTEELEEAKK 1395
Query: 618 RLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDK---- 673
+L E+ +S C +L+ ++ + L+R + AT LDK
Sbjct: 1396 KLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACAT---LDKKQRN 1452
Query: 674 ----MAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTL--VADNLDQATRV 727
+A W +K+ E Q + K+ + F +R+ V D L+ R
Sbjct: 1453 FDKVLAEWKQKLDESQAELEAAQ-------KESRSLSTELFKMRNAYEEVVDQLETLRRE 1505
Query: 728 AYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDS 787
K+ + + L QI E +G K K ++++ EEV E L+++
Sbjct: 1506 --NKNLQEEISDLTEQIAE-TGKNLQEAEKTKKLVEQEKSDLQVALEEV---EGSLEHEE 1559
Query: 788 KKAMQIQ----EQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELE 843
K +++Q + K +L+ +V++ +++ ++ ++Q + L+
Sbjct: 1560 SKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSV-------------LD 1606
Query: 844 ANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQ 903
A + + + +K +E +++ ++E ++ + + E H L+ Q
Sbjct: 1607 AEIRSRNDALRLKKKMEGDLN--------------EMEIQLGHSNRQMAETQKH-LRTVQ 1651
Query: 904 DKLDKINKQLDEC--ASAITKAQVAIKTADRN------LQKAQDSVLRTEKEIKDTEKEV 955
+L LD+ ++ K Q+AI RN L++ + ++ +TE+ + +E+E+
Sbjct: 1652 GQLKDSQLHLDDALRSNEDLKEQLAI-VERRNGLLLEELEEMKVALEQTERTRRLSEQEL 1710
Query: 956 DDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDA--LS 1013
D + ++ L + ++ E + + Q E N +QE + +E DA ++
Sbjct: 1711 LDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMA 1770
Query: 1014 IKLKLEQ-IDGHIAEHNSKIKYWHKEI--------------SKISLHPIEDNPIE---EI 1055
+LK EQ H+ ++ K++ K + +E+ E E+
Sbjct: 1771 EELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENEL 1830
Query: 1056 SVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNL-----------GAIAEYKKK-EELY 1103
V EA+K ++ + + E N+ + YK++ EE
Sbjct: 1831 DVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAE 1890
Query: 1104 LQRVAELDKITYERDSFRQAYE--DLRKQRLNEFMA 1137
Q +L + + +A E D+ + ++N+ A
Sbjct: 1891 EQANTQLSRCRRVQHELEEAAERADIAESQVNKLRA 1926
Score = 89.4 bits (220), Expect = 2e-17
Identities = 152/758 (20%), Positives = 320/758 (42%), Gaps = 101/758 (13%)
Query: 282 GEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKN----HVCQYYIYELQKRIAEM 337
GE+++ ++ V+++ + + E + I+ + E K C+ + + A+
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD 1267
Query: 338 ETQKEKIHE---DTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLD 394
E Q + IH+ + ++ LS+ ++ K + K +T+ +EE K +
Sbjct: 1268 EQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQME--- 1324
Query: 395 LEDVQVREKLKHATSKAKK----LEKQLQKDKEKVEEFKSIPAKSNNIINETTT------ 444
E+ + + + HA ++ L +Q ++++E E + +K+N+ + + T
Sbjct: 1325 -EETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDA 1383
Query: 445 --RNNALEKEKEKEEKKLKEVMD----------SLKQETQGLQKEKE------------- 479
R LE+ K+K ++L+E + SL++ Q LQ E E
Sbjct: 1384 IQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTAC 1443
Query: 480 -SREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTK---AKEALIAASETL- 534
+ +K+ F K + E + K+D +Q+EL+ + ++L K A E ++ ETL
Sbjct: 1444 ATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLR 1503
Query: 535 ---KERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLA 591
K + I D+ ++ +T + L+E EK + + QE++ DL +EE + SL
Sbjct: 1504 RENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKS-------DLQVALEEVEGSLE 1556
Query: 592 MNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIV---VDSI 648
S+ + + + KS + + ++ + A + LD + D++
Sbjct: 1557 HEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDAL 1616
Query: 649 DIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEI--QTPENTPRLFDLVKVKDEKIRQ 706
+ ++ L I + +MA K + + Q ++ L D ++ ++ Q
Sbjct: 1617 RLKKKMEGDLNEMEIQLGH--SNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQ 1674
Query: 707 AFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSS 766
R+ L+ + L++ +VA ++ R R ++ Q ++++ S + + +S
Sbjct: 1675 LAIVERRNGLLLEELEE-MKVALEQTERTRRLSEQ-ELLDASDRVQ------LLHSQNTS 1726
Query: 767 LVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQ 826
L+ + E + + Q + ++ IQE + EE+ K M L+K +
Sbjct: 1727 LINTKKKLEADIAQCQAEVEN----SIQESR-NAEEKAKKAITDAAMMAEELKKEQDTSA 1781
Query: 827 RLIEQEEYLNVQVKEL-----EANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVE 881
L ++ L VK+L EA LA KK+ + LE V + E D V +K G E
Sbjct: 1782 HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELD-VEQKRG-AE 1839
Query: 882 AEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSV 941
A +K H ++ +A++D +K + + K Q +K+ R ++A++
Sbjct: 1840 A-LKGAHKYERKVKEMTYQAEED-----HKNILRLQDLVDKLQAKVKSYKRQAEEAEEQA 1893
Query: 942 -------LRTEKEIKDTEKEVDDLTAELKSLEDKAAEV 972
R + E+++ + D +++ L K+ +V
Sbjct: 1894 NTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDV 1931
Score = 88.2 bits (217), Expect = 5e-17
Identities = 166/907 (18%), Positives = 367/907 (40%), Gaps = 166/907 (18%)
Query: 273 RVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLE----------NEIFRKKNHV 322
+V+ L+E + + KEK +L+ ++ L +E N ++
Sbjct: 978 KVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDD 1037
Query: 323 CQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKF 382
+ + + +K A++E K K+ D K E L N+ + + +K E +L+++
Sbjct: 1038 LEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAK 1097
Query: 383 IEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKD---KEKVEEFKSIPAKSNNII 439
I++ + + +Q ++K+K ++ ++LE++++ + + K+E+ +S A+ I
Sbjct: 1098 IDDEQ-------VHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEI 1150
Query: 440 NE-------TTTRNNALEKEKEKEEKKLKEVMD--SLKQETQG--LQKEKESREKELMGF 488
+E T+ + K++E E +K++ ++ +L+ E L+K++ EL
Sbjct: 1151 SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQ 1210
Query: 489 SKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIR------ 542
++ + K++ +SEL + + + + L+K+K + T++++ + I+
Sbjct: 1211 IDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQ 1270
Query: 543 -----------------------------DIEGKLPQTEQELKEKEKELQKLTQEETNFK 573
+ +L +++Q L ++ +EL++ +EET K
Sbjct: 1271 TQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAK 1330
Query: 574 S--------------LVHDLFQKVEEAKSSL--AMNRSRGKV--------LDAIIQEKKS 609
+ L+ + +++ +EAK+ L A++++ +V DAI +++
Sbjct: 1331 NAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAI---QRT 1387
Query: 610 GRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFI 669
+ +L E+ +S C +L+ ++ + L+R + AT
Sbjct: 1388 EELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACAT-- 1445
Query: 670 GLDK--------MAVWAKKMTEIQ---------TPENTPRLFDLVKVKDEKIRQAFYFAL 712
LDK +A W +K+ E Q + + LF + +E + Q
Sbjct: 1446 -LDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRR 1504
Query: 713 RDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQ------------SGTMTGGGSKVMK 760
+ + + + T + + + +++EQ G++ SK+++
Sbjct: 1505 ENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILR 1564
Query: 761 GRMGSSLV-IEISEEEVNKME--SQLQNDSKKAMQI-------------------QEQKV 798
++ S V E+ + + K E QL+ +S++A + ++ +
Sbjct: 1565 VQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEG 1624
Query: 799 QLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKL 858
L E ++L HS R+M T + +L + + +L+ ++ E A +++ L
Sbjct: 1625 DLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGL 1684
Query: 859 LEENVSAFKTEYDAVAEKAGKVEAE-------VKRLHNTIVEINNHKLKAQQDKLD---K 908
L E + K + E E V+ LH+ + N K K + D +
Sbjct: 1685 LLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAE 1744
Query: 909 INKQLDECASAITKAQVAIKTA---DRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSL 965
+ + E +A KA+ AI A L+K QD+ E+ K+ E+ V DL L
Sbjct: 1745 VENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEA 1804
Query: 966 EDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHI 1025
E A + ++ + +++ R L EL V Q+ K A + K++++
Sbjct: 1805 EQLALK------GGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQA 1858
Query: 1026 AEHNSKI 1032
E + I
Sbjct: 1859 EEDHKNI 1865
Score = 64.3 bits (155), Expect = 7e-10
Identities = 86/425 (20%), Positives = 172/425 (40%), Gaps = 57/425 (13%)
Query: 216 HGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIG-CGRLNEPIKVLCRRV 274
H DL ++ Q ++ K +E + +Y D I L E K L +R+
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401
Query: 275 EILNEHRGEKLNRVKMVEKEKDALEGE--------------------------KNIA--- 305
+ E+ ++ +EK K L+GE K +A
Sbjct: 1402 QEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWK 1461
Query: 306 --IEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMK 363
++ E E +K++ +++++ E+ Q E + + K + E+ + L+ ++
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIA 1521
Query: 364 AKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQK--- 420
K++++ EK TK + E ++ Q+ LE+V+ L+H SK +++ +L +
Sbjct: 1522 ETGKNLQEAEK-----TKKLVEQEKSDLQVALEEVE--GSLEHEESKILRVQLELSQVKS 1574
Query: 421 --DKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEK 478
D++ +E+ + I N + L+ E L+ LK++ +G E
Sbjct: 1575 ELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALR-----LKKKMEGDLNEM 1629
Query: 479 ESR----EKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETL 534
E + +++ K + + ++ +Q LD L + QL + E L
Sbjct: 1630 EIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEEL 1689
Query: 535 KERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNF----KSLVHDLFQKVEEAKSSL 590
+E K A+ E +EQEL + +Q L + T+ K L D+ Q E ++S+
Sbjct: 1690 EEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSI 1749
Query: 591 AMNRS 595
+R+
Sbjct: 1750 QESRN 1754
Score = 53.1 bits (126), Expect = 2e-06
Identities = 72/362 (19%), Positives = 158/362 (43%), Gaps = 59/362 (16%)
Query: 804 VVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLL---- 859
++K +E+EM E F + + L E + KELE +++ +K +L
Sbjct: 843 LLKSAEAEKEMATMKEDFERTKEELARSE----ARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 860 EENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEIN--NHKLKAQQDKLDKINKQLDECA 917
EN+ + + + + +EA+VK L + E N +L A++ L+ D+C+
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLE------DKCS 952
Query: 918 SAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN 977
S R++ + ++ + EKE TE +V +L+ E+ +LE+ +++ K
Sbjct: 953 SL-----------KRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKK 1001
Query: 978 AAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIK---- 1033
+ +Q+ H+ L +L+V ++ + L K ++ + + ++G + E K++
Sbjct: 1002 S-------LQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL-EQEKKLRADLE 1053
Query: 1034 ------YWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQ----------IA 1077
++S+ S+ +E++ + L ++ E + I ++ I
Sbjct: 1054 RAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIK 1113
Query: 1078 LLEARCHEMKPNLGA----IAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLN 1133
L+AR E++ + A A+ +K+ + + E+ + E A ++ K+R
Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREA 1173
Query: 1134 EF 1135
EF
Sbjct: 1174 EF 1175
Score = 43.1 bits (100), Expect = 0.002
Identities = 59/290 (20%), Positives = 123/290 (42%), Gaps = 37/290 (12%)
Query: 263 LNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHV 322
L E + ++ RR +L E E ++ E+ + E E A + + ++ +N
Sbjct: 1671 LKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRV----QLLHSQNTS 1726
Query: 323 CQYYIYELQKRIAEMETQKEKIHEDTKEINEKSN--ILSNEMKAKN-KDVKDTEKKLNKI 379
+L+ IA+ + + E ++++ EK+ I M A+ K +DT L ++
Sbjct: 1727 LINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786
Query: 380 TKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKL-----EKQLQKDKEKVEEFKSIPAK 434
K +E Q + L+H +A++L +KQ+QK + +V E +
Sbjct: 1787 KKNLE--------------QTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELE----- 1827
Query: 435 SNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNE 494
N ++ R K K E+K+KE+ +++ + + + ++ +K V
Sbjct: 1828 --NELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDK----LQAKVKS 1881
Query: 495 ARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDI 544
+ + + A+ + + LSR +L +A E A + + +A RD+
Sbjct: 1882 YKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDV 1931
Score = 31.6 bits (70), Expect = 5.1
Identities = 39/162 (24%), Positives = 72/162 (44%), Gaps = 19/162 (11%)
Query: 318 KKNHVCQYYIYELQKRIAEMETQ-----KEKIHEDTKEINEKSNILSNEMKAKNKDVKDT 372
KKN + + +LQ R+ E E K++I + + E N L E K + +K
Sbjct: 1787 KKN--LEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGA 1844
Query: 373 ---EKKLNKITKFIEENKEKFTQL-DLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEF 428
E+K+ ++T EE+ + +L DL D KL+ +K K ++Q ++ +E+
Sbjct: 1845 HKYERKVKEMTYQAEEDHKNILRLQDLVD-----KLQ---AKVKSYKRQAEEAEEQANTQ 1896
Query: 429 KSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQE 470
S + + + E R + E + K K ++V +E
Sbjct: 1897 LSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 106 bits (264), Expect = 2e-22
Identities = 186/919 (20%), Positives = 382/919 (41%), Gaps = 141/919 (15%)
Query: 331 QKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKF 390
++R ++E + +I + I ++ L +++ + EK K I +E+
Sbjct: 1894 KERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEEL 1953
Query: 391 TQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIIN----ETTTRN 446
+ + E Q+R +L + K L++ +K KEK +E +S ++ + I E +
Sbjct: 1954 SVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKT 2013
Query: 447 NALE------KEKEKEEKKLKEVMDSLKQETQG--------------LQKEKESREKELM 486
L+ E K++ L+E + SL++++Q L KEKE KE
Sbjct: 2014 ELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESE 2073
Query: 487 GFSKSVNEA-RSKMDVAQS---------ELDIYLSRHNTAVSQLTKAKEAL--------- 527
++E+ K++V+++ E + LS V QL + E L
Sbjct: 2074 SLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEK 2133
Query: 528 --IAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEE 585
+ +E LKER+ ++ K+ E+EL+ E+ + + + N K+ V L ++EE
Sbjct: 2134 KQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEE 2193
Query: 586 AKSSLAM-------NRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCH 638
SL + RS + L IQEK+ G+L +L + + +
Sbjct: 2194 MARSLKVFELDLVTLRSEKENLTKQIQEKQ--------GQLSELDKLLSSFKSLLEEKEQ 2245
Query: 639 ALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVK 698
A I +S + N LK N VA G + + + T + D
Sbjct: 2246 AEIQIKEESKTAVEMLQNQLKELNEAVAALCG------------DQEIMKATEQSLDPPI 2293
Query: 699 VKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKV 758
++ ++R + LR L AD Q + K+ L+G++ +
Sbjct: 2294 EEEHQLRNSIE-KLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLEREL----EIA 2348
Query: 759 MKGRMGSSLVIEISEEEVNKMESQLQ--NDSKKAMQIQEQKVQLE-ERVVKLRHSEREMR 815
+ ++L E S+ EV ++++++ S + +++ ++ E E + E+E
Sbjct: 2349 RTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERI 2408
Query: 816 NTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAE 875
+ LE +S + +++++E VQ+KE + + + K+ L E V+A + +A
Sbjct: 2409 SELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKE--LNERVAALHNDQEACKA 2466
Query: 876 KAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQ 935
K + ++V+ L E+ +L LD+ S++ ++ + L+
Sbjct: 2467 KEQNLSSQVECL-----ELEKAQL---LQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLE 2518
Query: 936 KAQDSVLRTEKEIKDTEKEVDDLT-------------AELKSLE---DKAAEVVKNTNAA 979
K + + R + +I+D E+ V L+ EL++L ++ +V+++ NA+
Sbjct: 2519 KKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNAS 2578
Query: 980 -EESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKE 1038
+++L +Q ++NL EL++ + ++ + + + K ++ + E K +E
Sbjct: 2579 LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEE 2638
Query: 1039 IS----------KISLHPIEDNPIEEISVLSPEDLEAIKNPD-----------SITNQIA 1077
+S ++ L I+ + +++ L+ E+ E K+ D + +IA
Sbjct: 2639 LSGEKNRLAGELQLLLEEIKSSK-DQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIA 2697
Query: 1078 LLEARCHEM-KPNLGAIAEYKKKEELYLQRVAELDKITYERD--SFRQAYEDLRKQRLNE 1134
+ R HE K + + + K+ E+ +Q E K+T + + S ++ DL K E
Sbjct: 2698 EYQLRLHEAEKKHQALLLDTNKQYEVEIQTYRE--KLTSKEECLSSQKLEIDLLKSSKEE 2755
Query: 1135 FMAGFYIITNKLKENYQML 1153
+ N LK Q+L
Sbjct: 2756 -------LNNSLKATTQIL 2767
Score = 100 bits (249), Expect = 9e-21
Identities = 183/902 (20%), Positives = 376/902 (41%), Gaps = 128/902 (14%)
Query: 264 NEPIKVLCRRVEI-LNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHV 322
N+ ++ +E+ L H E +V ++ + LE K IE + N+ +
Sbjct: 287 NQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRT 346
Query: 323 CQYYIYELQKRIAEMETQKEKIHEDT--KEINEKSNILSNEMKAKNKDVKDTEKKLNKIT 380
Y K A +E + +K+ ED + N +S S E K K K+ K+ +++L++
Sbjct: 347 TAQYDQASTKYTA-LEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKE-KEFQEELSR-- 402
Query: 381 KFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIIN 440
+ F LD E +Q++ +L +AK + LQ + +K+ K +
Sbjct: 403 -----QQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFK 457
Query: 441 ETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESR-------EKELMGFSKSVN 493
+ R + + +E +L+ M+ +K+E L+ E + E EL + +N
Sbjct: 458 QKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLN 517
Query: 494 EARSKMD-------------------VAQSELDIYLSRHNTAVSQLTKAKEALIAASETL 534
++++ + + Q E + L + AV+ L K ++ + + L
Sbjct: 518 QSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC---SQDLL 574
Query: 535 KERKAAIRDIEGKLPQTEQE-------LKEKEKELQKLTQEETNF---KSLVHDLFQKVE 584
K+R+ I + KL +TE+E L+ K+KE ++L +E+T F KS L ++E
Sbjct: 575 KKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQME 634
Query: 585 EAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIV 644
K +L +S+ L+ ++ ++ + R+ L E V I + + LD
Sbjct: 635 SEKENL---QSKINHLETCLKTQQI-KSHEYNERVRTLEMDRENLSVEIRNLHNVLD--- 687
Query: 645 VDSIDIAQECVNFLKRQNIGVATFIG------LDKMAVWAKKMT-EIQTPENTPRLFDLV 697
S+++ + + +++ Q A F ++ M + ++T +++ E+ +L
Sbjct: 688 SKSVEVETQKLAYMELQQ--KAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNE 745
Query: 698 KVKDEKIRQ---AFYFALRDTLVADNLDQATRVAYQK-----DRRWRVVTLQGQIIEQSG 749
+ ++ Q A Y +LRD L + + T +Q+ D++ + II + G
Sbjct: 746 IMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQG 805
Query: 750 TM-------------TGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQI--- 793
+M + S +++ R+ S +E S E +M S LQ ++ +QI
Sbjct: 806 SMPSERSECRLEADQSPKNSAILQNRVDS---LEFSLESQKQMNSDLQKQCEELVQIKGE 862
Query: 794 ------------QEQKVQLEERVVKLRHSEREMRN-------TLEKFTASIQRLIEQEEY 834
Q + +R+ KL+ +N LE +Q L ++ E
Sbjct: 863 IEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVET 922
Query: 835 LNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEI 894
+++EL+ + K+ +LL E +S K E ++ + E+ + + T+ EI
Sbjct: 923 EQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEI 982
Query: 895 NNHKLKAQQDKLDKINKQ------LDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEI 948
N Q+K++ I K +DE +I++ K L + + +++
Sbjct: 983 N---ASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDL 1039
Query: 949 KDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPE-IQKEHRNLLQELKVIQENEHAL 1007
K + ++L+ L ++ + +N E L E KEH+ L +L +E L
Sbjct: 1040 SQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNL 1099
Query: 1008 QKDALSIK--LKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEA 1065
+ +++ L+ E D ++NSK + + ++L ++ +E++ L E+ +
Sbjct: 1100 MLELETVQQALRSEMTDN---QNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL 1156
Query: 1066 IK 1067
+K
Sbjct: 1157 MK 1158
Score = 78.2 bits (191), Expect = 5e-14
Identities = 143/792 (18%), Positives = 343/792 (43%), Gaps = 66/792 (8%)
Query: 262 RLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNH 321
+L I+ L R+E + + ++K E+E D+L+ + LE E+ + +
Sbjct: 2116 QLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE------NLERELQMSEEN 2169
Query: 322 VCQYYIYELQKRIAEMETQKEKIHEDTKEIN--EKSNI-LSNEMKAKNKDVKDTEKKLNK 378
+ I + + AE+ET K +I E + + E + L +E + K +++ + +L++
Sbjct: 2170 Q-ELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSE 2228
Query: 379 ITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKV-------EEFKSI 431
+ K + K + + ++Q++E+ K A + L+ QL++ E V E K+
Sbjct: 2229 LDKLLSSFKSLLEEKEQAEIQIKEESKTA---VEMLQNQLKELNEAVAALCGDQEIMKAT 2285
Query: 432 PAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKS 491
+ I E N++EK + + E K+ + L+Q KE E L G
Sbjct: 2286 EQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQ-----LKESEHHADLLKG---R 2337
Query: 492 VNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQT 551
V ++++A++ + + ++ K + +++L+ + + I +
Sbjct: 2338 VENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENL 2397
Query: 552 EQELKEKEKELQKLTQEETNFKSLVHDLFQ-KVE-EAKSSLAMNRSRGKVLDAIIQEKKS 609
EL+++++ + +L ++F++++ + Q KV+ + KSS AM ++L ++E
Sbjct: 2398 TNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAM-----EMLQTQLKELNE 2452
Query: 610 GRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFI 669
R+ ++ A ++ + C ++ +D A+ N++ Q ++
Sbjct: 2453 -RVAALHNDQEACKAKEQNLSSQV-ECLELEKAQLLQGLDEAKN--NYIVLQ----SSVN 2504
Query: 670 GLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAY 729
GL + K+ E + E RL + ++ +++ + + L + + +
Sbjct: 2505 GLIQEVEDGKQKLE-KKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTV 2563
Query: 730 QKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEIS-EEEVNKMESQLQNDSK 788
+ +++ +V+ + ++ + + K ++ + + + ++S E+VNKM ++ +
Sbjct: 2564 ELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQR 2623
Query: 789 KAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLA 848
+ ++ ++ +L+E +L + + L+ I+ +Q + L ++ EL+ ++
Sbjct: 2624 EMHEMAQKTAELQE---ELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDC 2680
Query: 849 TAPDK-KKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLD 907
D+ +K+ + E ++ ++ +K + + + + ++ KL ++++ L
Sbjct: 2681 MHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLS 2740
Query: 908 KINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIK-DTEKEVDDLTAELKSLE 966
++D S+ K N KA +L K+ K D K V+ L E + +
Sbjct: 2741 SQKLEIDLLKSS--------KEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQ 2792
Query: 967 DKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIA 1026
K ++K+ EE +QKE L +L+ QE QK + K++++ I
Sbjct: 2793 GKMKLLIKSCKQLEEEKEILQKE----LSQLQAAQEK----QKTGTVMDTKVDELTTEIK 2844
Query: 1027 EHNSKIKYWHKE 1038
E ++ KE
Sbjct: 2845 ELKETLEEKTKE 2856
Score = 73.6 bits (179), Expect = 1e-12
Identities = 141/696 (20%), Positives = 299/696 (42%), Gaps = 118/696 (16%)
Query: 262 RLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNH 321
+L I+ L R+E + + L ++K E D L+G +E L E EI R
Sbjct: 2298 QLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGR----VENLERELEIARTNQ- 2352
Query: 322 VCQYYIYELQKRIAEMETQKEKIHEDTKEI-----------NEKSNILSNEMKAKNKDVK 370
++ E + E+ET K KI T+ + +EK N L+NE++ + + +
Sbjct: 2353 --EHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEN-LTNELQKEQERIS 2409
Query: 371 DTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKV----E 426
+ E + ++E ++ E VQ++EK +++ + L+ QL++ E+V
Sbjct: 2410 ELEIINSSFENILQEKEQ-------EKVQMKEK---SSTAMEMLQTQLKELNERVAALHN 2459
Query: 427 EFKSIPAKSNNIINETTTRNNALEKEKEK-----EEKK-----LKEVMDSLKQETQGLQK 476
+ ++ AK N+ ++ LE EK + +E K L+ ++ L QE + ++
Sbjct: 2460 DQEACKAKEQNLSSQV----ECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQ 2515
Query: 477 EKESREKELMGFSKSVNEAR---SKMDVAQSELDIYLSRHNTAVSQLTKAKEALI----- 528
+ E +++E+ + + SK+ + E ++ N + LT E I
Sbjct: 2516 KLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLW-KEQNLELRNLTVELEQKIQVLQS 2574
Query: 529 ---AASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEE 585
+ +TL+ +++ +++E +L T+ + +++ K+T +ET + +H++ QK E
Sbjct: 2575 KNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAE 2634
Query: 586 AKSSLAMNRSR-GKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIV 644
+ L+ ++R L +++E KS + +L +L E ++ S C D +
Sbjct: 2635 LQEELSGEKNRLAGELQLLLEEIKSSK-----DQLKELTL--ENSELKKSLDCMHKDQVE 2687
Query: 645 VDS---IDIAQECVNFLKRQNIGVATFIGLDK-----MAVWAKKMTEIQTPENTPRL-FD 695
+ +IA+ + + + A + +K + + +K+T + ++ +L D
Sbjct: 2688 KEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEID 2747
Query: 696 LVKVKDEKIRQAFYFA------LRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSG 749
L+K E++ + L+ T + DNL ++ + +R QG+
Sbjct: 2748 LLKSSKEELNNSLKATTQILEELKKTKM-DNLKYVNQLKKENER------AQGK------ 2794
Query: 750 TMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRH 809
MK + S +E +E + K SQLQ A + Q+ ++ +V +L
Sbjct: 2795 ---------MKLLIKSCKQLEEEKEILQKELSQLQ----AAQEKQKTGTVMDTKVDELTT 2841
Query: 810 SEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTE 869
+E++ TLE+ T +++ L + ++LE K +++LE V+ ++
Sbjct: 2842 EIKELKETLEEKTKEADEYLDKYCSLLISHEKLE----------KAKEMLETQVAHLCSQ 2891
Query: 870 YDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDK 905
+ + V + I + +L + Q+K
Sbjct: 2892 QSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNK 2927
Score = 67.8 bits (164), Expect = 6e-11
Identities = 176/956 (18%), Positives = 373/956 (39%), Gaps = 174/956 (18%)
Query: 273 RVEILNEHRGEKLNRVKMVEKEKDALEGEK-NIAIEFLTLENEIFRKKNHVCQYYIYELQ 331
+ E L E +++ K +E E AL+ +K + + T+ + + + ++ +
Sbjct: 163 KYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQE 222
Query: 332 KRIAEMET--QKEKIHED--------TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITK 381
K + + + Q+ I D +E+ + L + N D + + +
Sbjct: 223 KTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQ 282
Query: 382 FIEENKE---KFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNI 438
+N+E K +L+L +++K +K ++L+ QL+K K ++ E + + K +
Sbjct: 283 LKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDE 342
Query: 439 INETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSK 498
+ TT + + + E+KLK++ + L + Q + + S E+++ K E S+
Sbjct: 343 LVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSR 402
Query: 499 MDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEK 558
+ LD + ++Q +L Q +
Sbjct: 403 QQRSFQTLDQECIQMKARLTQ---------------------------ELQQAKNMHNVL 435
Query: 559 EKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGR 618
+ EL KLT + ++ + + QK+ A+ + ++ + L ++E K
Sbjct: 436 QAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKK--------- 486
Query: 619 LGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWA 678
+ + + CH + + ++C+N + QN +A
Sbjct: 487 --ENNLLKSHSEQKAREVCH-----LEAELKNIKQCLN--QSQN--------------FA 523
Query: 679 KKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATR-VAYQKDRRWRV 737
++M T + T +++ EKI Q ++L + L A + Q+D +
Sbjct: 524 EEMKAKNTSQET-----MLRDLQEKINQQ-----ENSLTLEKLKLAVADLEKQRDCSQDL 573
Query: 738 VTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQL-----QNDSKKAMQ 792
+ + IEQ K K + S+L ++ E E K E L + K Q
Sbjct: 574 LKKREHHIEQLNDKLSKTEKESKALL-SALELKKKEYEELKEEKTLFSCWKSENEKLLTQ 632
Query: 793 IQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPD 852
++ +K L+ ++ L + + ++ ++ L E L+V+++ L + + + +
Sbjct: 633 MESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVE 692
Query: 853 KKKQKL--------LEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINN-------- 896
+ QKL E + + E + + K ++ +V+ L + + ++N
Sbjct: 693 VETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRC 752
Query: 897 -HKLKAQQDKLDKINKQLDECASAITK-----------AQVAIKTADRNLQKAQDSV--- 941
L A+ + L + K D AS +T Q A+ + N+ Q S+
Sbjct: 753 YQDLHAEYESLRDLLKSKD--ASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810
Query: 942 -----LRTEKEIKDT---EKEVDDLTAELKS-------LEDKAAEVVKNTNAAEESLPEI 986
L ++ K++ + VD L L+S L+ + E+V+ EE+L +
Sbjct: 811 RSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKA 870
Query: 987 QKEHRNLL----QELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKI 1042
++ H++ + Q + +QE+ A Q LE + + N K++ EI ++
Sbjct: 871 EQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQEL 930
Query: 1043 --SLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYK--- 1097
S H +ED+ ++E+ +LS E L K +++ I+L + E+ G + E
Sbjct: 931 KKSNHLLEDS-LKELQLLS-ETLSLEKK--EMSSIISLNKREIEELTQENGTLKEINASL 986
Query: 1098 --------KKEELYLQRVAELDK-ITYERDSFRQ--------------AYEDLRKQ 1130
+K E + + E +K I+ D ++Q AYEDL ++
Sbjct: 987 NQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQK 1042
Score = 66.6 bits (161), Expect = 1e-10
Identities = 139/651 (21%), Positives = 267/651 (41%), Gaps = 101/651 (15%)
Query: 448 ALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELD 507
ALE+ KE + + + L+ + L+KEK+ R+ +L ++ + + K++ ++E
Sbjct: 4 ALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTE-G 62
Query: 508 IYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQ 567
L R N + ++ ++ E +T ++ ++ E ++ E +L +K+++KL Q
Sbjct: 63 TNLKRENQRLMEICESLE------KTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQ 116
Query: 568 EETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDE 627
E KS + Q + A SL + K+ + P Y + E
Sbjct: 117 ELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPL-------TPSQYYSGSKYEDLKE 169
Query: 628 KYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTP 687
KY+ + + A + + + +A + W ++ T
Sbjct: 170 KYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLS 229
Query: 688 ENTPRLFDLVKVKDEKIRQAF---YFA-------LRDTLVADNLDQATRVAYQKDRRWRV 737
N+ R IR+ F YF+ R TL D + +
Sbjct: 230 SNSQR---------TPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLL 280
Query: 738 VTLQGQ------IIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNK-MESQLQNDSKKA 790
L+ Q I + G K MKG +VNK E QLQ + K
Sbjct: 281 DQLKAQNQELRNKINELELRLQGHEKEMKG-------------QVNKFQELQLQLEKAKV 327
Query: 791 MQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELE-ANVLAT 849
I+++KV L + +L + + K+TA Q+L + E L+ Q + E A
Sbjct: 328 ELIEKEKV-LNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLE 386
Query: 850 APDKKKQKLLEENVSAFKTEYDAVAEKAGKVEA-------EVKRLHNTIVEINNHKLKAQ 902
K+K+K +E +S + + + ++ +++A + K +HN L+A+
Sbjct: 387 QKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNV--------LQAE 438
Query: 903 QDKLDKINKQ----LDECASAITKAQVAIKTAD-------RNLQ--KAQDSVLRTEKEIK 949
DKL + +Q L+E + +A+ A + + R+++ K ++++L++ E K
Sbjct: 439 LDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQK 498
Query: 950 DTEKEVDDLTAELKSLE------DKAAEVVKNTNAAEESLPE------IQKEHRNLLQEL 997
+EV L AELK+++ AE +K N ++E++ Q+E+ L++L
Sbjct: 499 --AREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKL 556
Query: 998 KVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIE 1048
K+ + L+K + L++ + HI + N K+ KE SK L +E
Sbjct: 557 KLAVAD---LEKQRDCSQDLLKKREHHIEQLNDKLSKTEKE-SKALLSALE 603
Score = 66.2 bits (160), Expect = 2e-10
Identities = 196/1072 (18%), Positives = 421/1072 (39%), Gaps = 168/1072 (15%)
Query: 132 YRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNS--NFYVSRTA 189
Y A + + KKL+ + ++ + C++E QKI +KE + E + +F
Sbjct: 357 YTALEQKLKKLTEDLSCQRQNAESARCSLE---QKIKEKEKEFQEELSRQQRSFQTLDQE 413
Query: 190 CRDNTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEG 249
C I K + +++ H + LQ E++++ +K + + +E
Sbjct: 414 C--------IQMKARLTQELQQAKNMHNV---------LQAELDKLTSVKQQLENNLEEF 456
Query: 250 MLE-------YLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKE----KDAL 298
+ + I L ++ + + +L H +K V +E E K L
Sbjct: 457 KQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516
Query: 299 EGEKNIAIEFLT-----------LENEIFRKKNHVCQYYIYELQKRIAEMETQK------ 341
+N A E L+ +I +++N + + +L+ +A++E Q+
Sbjct: 517 NQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLT---LEKLKLAVADLEKQRDCSQDL 573
Query: 342 --------EKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQL 393
E++++ + ++S L + ++ K K+ ++ +++ + + EN++ TQ+
Sbjct: 574 LKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQM 633
Query: 394 DLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALE-KE 452
+ E ++ K+ H + L+ Q K E E +++ N+ E +N L+ K
Sbjct: 634 ESEKENLQSKINHLET---CLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS 690
Query: 453 KEKEEKKL--KEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSEL---- 506
E E +KL E+ + Q QKE E+ + + V + K+ + +E+
Sbjct: 691 VEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKD 750
Query: 507 DIYLSRH--NTAVSQLTKAKEALIAASETLKERKAA----------IRDIEGKLPQTEQE 554
Y H ++ L K+K+A + +E + A +I G+ E
Sbjct: 751 RCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSE 810
Query: 555 LKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPG 614
E E + + ++ V L +E K MN K + ++Q K
Sbjct: 811 RSECRLEADQSPKNSAILQNRVDSLEFSLESQKQ---MNSDLQKQCEELVQIK------- 860
Query: 615 IYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKM 674
G I+E ++ + H ++ S I++ + QN+ T L+
Sbjct: 861 --------GEIEE--NLMKAEQMHQ-SFVAETSQRISKLQEDTSAHQNVVAETLSALE-- 907
Query: 675 AVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQ----ATRVAYQ 730
K E+Q L D V+ + +I++ + L+ D+L + + ++ +
Sbjct: 908 ----NKEKELQL------LNDKVETEQAEIQE---LKKSNHLLEDSLKELQLLSETLSLE 954
Query: 731 KDRRWRVVTLQGQIIE----QSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQND 786
K +++L + IE ++GT+ + + + +M +I+ SE N ++ + ++
Sbjct: 955 KKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMN---LIQKSESFANYIDEREKSI 1011
Query: 787 SKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANV 846
S+ + Q +++K+ L +R E N E + + E+ L + E
Sbjct: 1012 SELSDQYKQEKLILLQRC-------EETGNAYEDLSQKYKAAQEKNSKLECLLNE----- 1059
Query: 847 LATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKL 906
T+ + ++ LE+ AF E+ K E +R N ++E+ + + +
Sbjct: 1060 -CTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAE---ERNQNLMLELETVQQALRSEMT 1115
Query: 907 DKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLE 966
D N E A + + + +K +QK + +L+ +++ K E ++LE
Sbjct: 1116 DNQNNSKSE-AGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMK----TKHECQNLE 1170
Query: 967 DKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDAL----SIKLKLEQID 1022
+ +E + + + ++E+ + N +Q +A+ +KL+ + +
Sbjct: 1171 SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKE 1230
Query: 1023 GHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEA----IKNPDSI-TNQIA 1077
+H + E S ++D +EIS L +++A I P + T+Q
Sbjct: 1231 KECLQHELQTIRGDLETSN-----LQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQND 1285
Query: 1078 LLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRK 1129
+C ++ + + E +K E+ EL +T DS + RK
Sbjct: 1286 NAHLQC-SLQTTMNKLNELEKICEILQAEKYEL--VTELNDSRSECITATRK 1334
Score = 59.3 bits (142), Expect = 2e-08
Identities = 85/421 (20%), Positives = 168/421 (39%), Gaps = 50/421 (11%)
Query: 794 QEQKVQLEERVVKLRHSERE----MRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLAT 849
+ + + + V K+ S +E + N L + + + + YL ++ ++ L
Sbjct: 1876 KSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCL 1935
Query: 850 APDKK-KQKL---LEENVSA-------FKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHK 898
D + KQK+ LEE +S + E D +++K ++ +++ E+ +H+
Sbjct: 1936 EKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQ 1995
Query: 899 -------------LKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTE 945
+K + + L ++ + E T Q +++ +++ Q + E
Sbjct: 1996 SECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELE 2055
Query: 946 KEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEH 1005
+I KE + L E +SL+ + +E ++L E L QE H
Sbjct: 2056 NQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVH 2115
Query: 1006 ALQKDALSIKLKLEQIDG---HIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPED 1062
L++ +++++E + HIAE K +E SL +N E+ +
Sbjct: 2116 QLRRGIEKLRVRIEADEKKQLHIAE-----KLKERERENDSLKDKVENLERELQMSEENQ 2170
Query: 1063 LEAIKNPDSITNQIALLEARCHEMKPN-----LGAIAEYKKKEELYLQ------RVAELD 1111
I + ++ ++ L+ + EM + L + +KE L Q +++ELD
Sbjct: 2171 ELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELD 2230
Query: 1112 KITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKE-NYQMLTLGGDAEL--ELVDSLD 1168
K+ S + E Q E ++ N+LKE N + L GD E+ SLD
Sbjct: 2231 KLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLD 2290
Query: 1169 P 1169
P
Sbjct: 2291 P 2291
Score = 57.8 bits (138), Expect = 7e-08
Identities = 78/398 (19%), Positives = 171/398 (42%), Gaps = 48/398 (12%)
Query: 231 EVEQIAMMKPKGQTEHD----EGMLEYLEDIIGCGRLNEP------------IKVLCRRV 274
E +Q+ +++ ++EH +G +E LE + R N+ ++ L ++
Sbjct: 2314 EKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKI 2373
Query: 275 EILNEH-RGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKR 333
E + + RG +L+ V + EK+ L E E ++ I ++ Q E +
Sbjct: 2374 EGMTQSLRGLELD-VVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQM 2432
Query: 334 IAEMETQKEKIHEDTKEINEKSNILSNEM---KAKNKD----VKDTEKKLNKITKFIEEN 386
+ T E + KE+NE+ L N+ KAK ++ V+ E + ++ + ++E
Sbjct: 2433 KEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2492
Query: 387 KEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINE----- 441
K + L + ++++ K +K ++++ + K ++++ + + +K + + E
Sbjct: 2493 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWK 2552
Query: 442 ---TTTRNNALEKEK-----EKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVN 493
RN +E E+ + + L++ ++ L+ + L+ E E + + M F + VN
Sbjct: 2553 EQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVN 2612
Query: 494 EARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQ 553
+ +K Q E+ + +L+ K L + L E + +D +L
Sbjct: 2613 KMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENS 2672
Query: 554 ELKEK---------EKELQKLTQEETNFKSLVHDLFQK 582
ELK+ EKE K+ +E ++ +H+ +K
Sbjct: 2673 ELKKSLDCMHKDQVEKE-GKVREEIAEYQLRLHEAEKK 2709
Score = 57.8 bits (138), Expect = 7e-08
Identities = 78/346 (22%), Positives = 155/346 (44%), Gaps = 53/346 (15%)
Query: 283 EKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKE 342
EK+N KM KE + +A + L+ E+ +KN + ELQ + E+++ K+
Sbjct: 2609 EKVN--KMTAKETELQREMHEMAQKTAELQEELSGEKNRLAG----ELQLLLEEIKSSKD 2662
Query: 343 KIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNK-ITKF---IEENKEKFTQLDLE-- 396
++ E T E +E L + +KD + E K+ + I ++ + E ++K L L+
Sbjct: 2663 QLKELTLENSE----LKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTN 2718
Query: 397 ---DVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTT--------- 444
+V+++ + TSK E+ L K +++ KS + NN + TT
Sbjct: 2719 KQYEVEIQTYREKLTSK----EECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTK 2774
Query: 445 -----RNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKM 499
N L+KE E+ + K+K ++ S KQ L++EKE +KEL S +A +
Sbjct: 2775 MDNLKYVNQLKKENERAQGKMKLLIKSCKQ----LEEEKEILQKEL-----SQLQAAQEK 2825
Query: 500 DVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKE 559
+ +D + T + +L + E ++ ++ ++ KL + ++ L+ +
Sbjct: 2826 QKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQV 2885
Query: 560 KEL-QKLTQEETNFKSLVHDL------FQKVEEAKSSLAMNRSRGK 598
L + +++++ L+ + V E + S N++ GK
Sbjct: 2886 AHLCSQQSKQDSRGSPLLGPVVPGPSPIPSVTEKRLSSGQNKASGK 2931
Score = 53.9 bits (128), Expect = 1e-06
Identities = 173/949 (18%), Positives = 370/949 (38%), Gaps = 164/949 (17%)
Query: 332 KRIAEMETQKEKIHEDTKE-----------INEKSNILSNEMKAKNKDVKDTEKKLNKIT 380
++I E+E Q +K+ ++ ++ + ++ + NE K + ++K ++L +I
Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENE-KTEGTNLKRENQRLMEIC 76
Query: 381 KFIEENKEKFT-QLDLEDVQVR---EKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSN 436
+ +E+ K+K + +L +++ QV +L + +KLE++L++ K ++E + ++
Sbjct: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
Query: 437 NIINETTTRNNAL------------EKEKEKEEKKLKEVMDS--LKQETQGLQKEKESR- 481
+N T K ++ +EK KEV + L+ E + LQ +K S+
Sbjct: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQT 196
Query: 482 -------------------------EKELMGFSKSVNEARSKMDVAQS----ELDIYLSR 512
EK S + + D + S E ++ SR
Sbjct: 197 LPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSR 256
Query: 513 HNTAVSQLTKAKEALIAASET--LKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEET 570
+ + +S L + KA +++ K+ + E L+ EKE++ +
Sbjct: 257 STLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKG---QVN 313
Query: 571 NFKSLVHDLFQ-KVEEAKSSLAMNRSRGKVLDAIIQ-EKKSGRIPGIYGRLGDLGA-IDE 627
F+ L L + KVE + +N+ R +++ Q ++ S + + +L L +
Sbjct: 314 KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373
Query: 628 KYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTP 687
+ A S+ C I + +E L RQ T + + + + A+ E+Q
Sbjct: 374 QRQNAESARCSLEQKIKEKEKEFQEE----LSRQQRSFQT-LDQECIQMKARLTQELQQA 428
Query: 688 ENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQ 747
+N + K ++Q + +NL++ + + ++ ++ ++ + +
Sbjct: 429 KNMHNVLQAELDKLTSVKQQ---------LENNLEEFKQKLCRAEQAFQASQIKENELRR 479
Query: 748 SGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQE-----------Q 796
S + ++K E EV +E++L+N + Q Q Q
Sbjct: 480 SMEEMKKENNLLKSHS------EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQ 533
Query: 797 KVQLEERVVKLRHSEREMRNTLEKFTASI----------QRLIEQEEY--------LNVQ 838
+ L + K+ E + TLEK ++ Q L+++ E+ L+
Sbjct: 534 ETMLRDLQEKINQQENSL--TLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKT 591
Query: 839 VKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHK 898
KE +A + A KK+ + L+E + F + ++E+E + L + I +
Sbjct: 592 EKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLET-C 650
Query: 899 LKAQQDKLDKINKQLDECASAITKAQVAIKTADRNL------------------QKAQDS 940
LK QQ K + N+++ V I+ L QKA+ S
Sbjct: 651 LKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFS 710
Query: 941 VLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVI 1000
+ +KEI++ + LT +++ LE K + + ++ E+ +L LK
Sbjct: 711 DQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLK-- 768
Query: 1001 QENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSP 1060
KDA + + +H + + ++ ++H N I E +
Sbjct: 769 -------SKDASLVTNE---------DHQRSLLAFDQQ---PAMHHSFANIIGEQGSMPS 809
Query: 1061 EDLEAIKNPDSITNQIALLEARCHEMKPNLGA----IAEYKKKEELYLQRVAELDKITYE 1116
E E D A+L+ R ++ +L + ++ +K+ E +Q E+++ +
Sbjct: 810 ERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMK 869
Query: 1117 RDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELELVD 1165
+ Q++ QR+++ N + E L + EL+L++
Sbjct: 870 AEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALE-NKEKELQLLN 917
Score = 53.9 bits (128), Expect = 1e-06
Identities = 162/901 (17%), Positives = 365/901 (40%), Gaps = 136/901 (15%)
Query: 322 VCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKD--------VKD-- 371
+C+ E + + E+ + + T+++ E+ L NE+K N D V+D
Sbjct: 1306 ICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIP 1365
Query: 372 --------TEKKLNKITKFIEENKEKFTQLDLEDVQ-----VREKLKHATSKAKKLEKQL 418
E+ + E N + L ++VQ ++EK S+ K L Q
Sbjct: 1366 GGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQH 1425
Query: 419 QKDKEKVEEFKSI--PAKSNNIINETTTRNNALEKEKEK----EEKKLKEVMDSLKQETQ 472
+ K+ E ++ K+ N++ T RN + KE EE + + S ++
Sbjct: 1426 CQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSS 1485
Query: 473 GLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQL--TKAKEALIAA 530
L +S F +++ E M + S L+ +S + +V ++ + +E +
Sbjct: 1486 SLSSLGDS------SFYRALLEQTGDMSLL-SNLEGAVSANQCSVDEVFCSSLQEENLTR 1538
Query: 531 SETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSL 590
ET + ++E Q L++ E +K+ + + +L Q + + L
Sbjct: 1539 KETPSAPAKGVEELESLCEVYRQSLEKLE---EKMESQGIMKNKEIQELEQLLSSERQEL 1595
Query: 591 AMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDI 650
R + + Q+K + + +L A ++K +S + ++ +
Sbjct: 1596 DCLRKQYLSENEQWQQKLTSVTLEMESKL----AAEKKQTEQLS--------LELEVARL 1643
Query: 651 AQECVNFLKRQNIGVAT---FIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQA 707
+ ++ R +G+ T G ++ +K+ T +T E TP+ D+ ++ D+ +Q
Sbjct: 1644 QLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTS-ETTERTPK-HDVHQICDKDAQQD 1701
Query: 708 FYFALRDTLVADNL--------DQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVM 759
+ + +Q+ Y+ + I E S +G + V
Sbjct: 1702 LNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELS--FSGPNALVP 1759
Query: 760 KGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQI------QEQKV-----QLEERVVKLR 808
+G+ +E+++ ++ +++ S + +++ +++KV +++E KL
Sbjct: 1760 MDFLGN-------QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLH 1812
Query: 809 HSEREMRN------TLEKFTASIQR----LIEQEEYLNVQVKELEANV---------LAT 849
E ++ LEK +++ L E+ EY + +EL V L
Sbjct: 1813 LQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEM 1872
Query: 850 APDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQD----- 904
DK ++ + +NV+ D+ E+ VE E+ R+ + I + L + D
Sbjct: 1873 HADKSSREDIGDNVAKVN---DSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQ 1929
Query: 905 ------KLDKINKQ-----LDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEK 953
+ D NKQ L+E S +T + ++ + K ++ + +++K+ +
Sbjct: 1930 TEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQ 1989
Query: 954 EVDDLTAE-LKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDAL 1012
E++ +E L ++ AEV + T E L + + LL++ +QE +L+KD+
Sbjct: 1990 ELESHQSECLHCIQVAEAEVKEKT----ELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQ 2045
Query: 1013 SIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSI 1072
++ L +++ IA+ N + + KE + + ++ E+++V + A+
Sbjct: 2046 ALSLTKCELENQIAQLNKEKELLVKESESLQAR-LSESDYEKLNVSKALE-AALVEKGEF 2103
Query: 1073 TNQIALLEARCHEMKPNLGAI---AEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRK 1129
+++ + H+++ + + E +K++L++ +L + E DS + E+L +
Sbjct: 2104 ALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHI--AEKLKERERENDSLKDKVENLER 2161
Query: 1130 Q 1130
+
Sbjct: 2162 E 2162
Score = 33.5 bits (75), Expect = 1.3
Identities = 56/252 (22%), Positives = 98/252 (38%), Gaps = 48/252 (19%)
Query: 924 QVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDK--------------- 968
Q I +++ + LR I+D +++V+ L E+K L+ K
Sbjct: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEAC 1825
Query: 969 ------AAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQID 1022
E+ K + E L +H+ LLQ ++ + L+ A K E I
Sbjct: 1826 IELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHA--DKSSREDIG 1883
Query: 1023 GHIAEHNSKIKYWHKEI-SKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEA 1081
++A+ N K ++ +++S E IE ++ DLE ++ E
Sbjct: 1884 DNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQT-----------EK 1932
Query: 1082 RCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYI 1141
C E K N E K+K + L+ EL +T ER+ R + + K+
Sbjct: 1933 LCLE-KDN-----ENKQKVIVCLEE--ELSVVTSERNQLRGELDTMSKK-----TTALDQ 1979
Query: 1142 ITNKLKENYQML 1153
++ K+KE Q L
Sbjct: 1980 LSEKMKEKTQEL 1991
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 105 bits (263), Expect = 2e-22
Identities = 196/993 (19%), Positives = 418/993 (42%), Gaps = 138/993 (13%)
Query: 228 LQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEH-RGEKLN 286
L + ++ K Q H + + + + LN+ L ++VE L EK
Sbjct: 986 LDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKL 1045
Query: 287 RVKMVEKEKDALEGEKNIAIE-FLTLENE-------IFRKKNHVCQYYIYELQKRIAEME 338
RV + E+ K LEG+ +A E L LEN+ + +K CQ LQ ++ + +
Sbjct: 1046 RVDL-ERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQ-----LQSKVEDEQ 1099
Query: 339 TQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKF-------- 390
T + + KE+ + L E++A+ TEK+ + + +EE E+
Sbjct: 1100 TLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTS 1159
Query: 391 TQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALE 450
TQ++L + E LK + LE+ + + V + A S + E ++
Sbjct: 1160 TQIELNKKREAEFLK----LRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVK 1215
Query: 451 KEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQ---SELD 507
++ EKE+ + K +D L + + K K + EK ++EAR K + Q SEL
Sbjct: 1216 QKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELT 1275
Query: 508 IYLSRHNTAVSQLTKA---KEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQK 564
SR T +L++ KE+++ S+ + ++A + E Q E+E K K L
Sbjct: 1276 TQKSRLQTEAGELSRQLEEKESIV--SQLSRSKQAFTQQTEELKRQLEEENKAKNA-LAH 1332
Query: 565 LTQEETNFKSLVHDLFQKVEEAKSSL--AMNRSRGKVL--------DAIIQEKKSGRIPG 614
Q + L+ + +++ +E K+ L A++++ +V DAI +++ +
Sbjct: 1333 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAI---QRTEELEE 1389
Query: 615 IYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDK- 673
+L E+ A+++ C +L+ ++ + ++R N A LDK
Sbjct: 1390 AKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAA---LDKK 1446
Query: 674 -------MAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATR 726
+A W K E Q +K+ + F L++ + LDQ
Sbjct: 1447 QRNFDKVLAEWKTKCEESQAELEA-------SLKESRSLSTELFKLKNAY-EEALDQLET 1498
Query: 727 VAYQ-KDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQN 785
V + K+ + L QI E T+ ++ K R L + + + E+ L++
Sbjct: 1499 VKRENKNLEQEIADLTEQIAENGKTI----HELEKSRKQIELEKADIQLALEEAEAALEH 1554
Query: 786 DSKKAMQIQEQKVQLEERVV-KLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEA 844
+ K ++IQ + Q++ + K+ + E +E+ + QR +E + L+A
Sbjct: 1555 EEAKILRIQLELTQVKSEIDRKIAEKDEE----IEQLKRNYQRTVETMQ------SALDA 1604
Query: 845 NVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNH---KLKA 901
V + + +K +E +++ + + +A + ++ + + + H L+
Sbjct: 1605 EVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRG 1664
Query: 902 QQD----------KLDKINKQLDECASAITKAQVAIKTADRNLQKAQD----------SV 941
Q+D + + + +++E + + + + A K A++ L + + S+
Sbjct: 1665 QEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSL 1724
Query: 942 LRTEKEIK----DTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPE-------IQKEH 990
+ T+K+++ + EV+D + + ++ E+KA + + + E L + +++
Sbjct: 1725 IHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1784
Query: 991 RNLLQELKVIQEN-EHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIE- 1048
+NL Q +K +Q + A Q K ++++++ I E +++ K+ ++ S+ +
Sbjct: 1785 KNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTE-SVKGLRK 1843
Query: 1049 -DNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKK-EELYLQR 1106
+ ++E++ S ED + + + +++ + + YK++ EE Q
Sbjct: 1844 YERRVKELTYQSEEDRKNVLRLQDLVDKLQV-------------KVKSYKRQAEEADEQA 1890
Query: 1107 VAELDKITYERDSFRQAYE--DLRKQRLNEFMA 1137
A L K + +A E D+ + ++N+ A
Sbjct: 1891 NAHLTKFRKAQHELEEAEERADIAESQVNKLRA 1923
Score = 99.0 bits (245), Expect = 3e-20
Identities = 166/841 (19%), Positives = 357/841 (42%), Gaps = 89/841 (10%)
Query: 329 ELQK---RIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEE 385
E QK +A+ E +++++ E + ++ N L +++A+++++ D E++ +++ K +
Sbjct: 856 EFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQ 915
Query: 386 NKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAK-------SNNI 438
+ K ++ E T+K +KLE + + K+ +++ + AK + N
Sbjct: 916 LEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK 975
Query: 439 INETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSK 498
+ T + L++ K ++ K + ++ +Q LQ E++ S+N+ +SK
Sbjct: 976 VKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDK--------VNSLNKTKSK 1027
Query: 499 MDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEK 558
++ +L+ L + L + K L LK + +I D+E Q ++ LK+K
Sbjct: 1028 LEQQVEDLESSLEQEKKLRVDLERNKRKL---EGDLKLAQESILDLENDKQQLDERLKKK 1084
Query: 559 EKEL----QKLTQEET---NFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGR 611
+ E K+ E+T F+ + +L ++EE + + R+ K+ +
Sbjct: 1085 DFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERA---------TRAKTEK 1135
Query: 612 IPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQEC-VNFLK-RQNIGVATFI 669
Y R +L + E+ + A + I++ ++ FLK R+++ AT
Sbjct: 1136 QRSDYAR--ELEELSERLEEA--------GGVTSTQIELNKKREAEFLKLRRDLEEATLQ 1185
Query: 670 GLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAY 729
+A KK + E ++ +L +VK + ++ F L ++ +++ ++
Sbjct: 1186 HEAMVAALRKKHAD-SVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKA 1244
Query: 730 QKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKK 789
++ R TL+ Q+ E G ++ + + + E ++ QL+
Sbjct: 1245 NLEKICR--TLEDQLSEARGK----NEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESI 1298
Query: 790 AMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLAT 849
Q+ K ++ +L+ E ++Q + L Q +E +
Sbjct: 1299 VSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQE---GK 1355
Query: 850 APDKKKQKLLEENVSAFKTEYDAVA-EKAGKVEAEVKRLHNTI------VEINNHKLKAQ 902
A ++ V+ ++T+Y+ A ++ ++E K+L + VE N K +
Sbjct: 1356 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASL 1415
Query: 903 QDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAEL 962
+ ++ ++++ + +A D+ Q+ D VL K E+ +L A L
Sbjct: 1416 EKTKQRLQGEVEDLMVDVERANSLAAALDKK-QRNFDKVLAEWK--TKCEESQAELEASL 1472
Query: 963 KSLEDKAAEVVKNTNAAEESLPE---IQKEHRNLLQEL----KVIQENE---HALQKDAL 1012
K + E+ K NA EE+L + +++E++NL QE+ + I EN H L+K
Sbjct: 1473 KESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRK 1532
Query: 1013 SIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIE-DNPIEEISVLSPEDLEAIKNPDS 1071
I+L+ I + E + +++ +I +I L + + I+ E++E +K
Sbjct: 1533 QIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQ 1592
Query: 1072 ITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYE-RDSFRQAYEDLRKQ 1130
T + + A E++ AI KK E +L++I + + RQA E L+
Sbjct: 1593 RTVE-TMQSALDAEVRSRNEAIRLKKKME-------GDLNEIEIQLSHANRQAAETLKHL 1644
Query: 1131 R 1131
R
Sbjct: 1645 R 1645
Score = 93.6 bits (231), Expect = 1e-18
Identities = 142/792 (17%), Positives = 339/792 (42%), Gaps = 79/792 (9%)
Query: 273 RVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQK 332
+V+ L E + + +EK AL+ A++ L E + N +L++
Sbjct: 975 KVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKS----KLEQ 1030
Query: 333 RIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQ 392
++ ++E+ E+ + ++ L ++K + + D E ++ + +++ ++ Q
Sbjct: 1031 QVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQ 1090
Query: 393 LD--LED-----VQVREKLKHATSKAKKLEKQLQKDKE---KVEEFKSIPAKSNNIINE- 441
L +ED +Q ++K+K ++ ++LE++++ ++ K E+ +S A+ ++E
Sbjct: 1091 LQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSER 1150
Query: 442 ------TTTRNNALEKEKEKEEKKLKEVMD--SLKQETQ--GLQKEKESREKELMGFSKS 491
T+ L K++E E KL+ ++ +L+ E L+K+ EL +
Sbjct: 1151 LEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDN 1210
Query: 492 VNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQT 551
+ + K++ +SE + + ++++ ++K+K L + R +E +L +
Sbjct: 1211 LQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANL----------EKICRTLEDQLSEA 1260
Query: 552 EQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGR 611
+ +E ++ L +LT +++ ++ +L +++EE K S+ SR K A Q+ +
Sbjct: 1261 RGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE-KESIVSQLSRSK--QAFTQQTEE-- 1315
Query: 612 IPGIYGRLGDLGAIDEKYDVAISSCCHALDYI---VVDSIDIAQECVNFLKRQNIGVA-- 666
+ +L + A+ S H D + + + E L + N VA
Sbjct: 1316 ---LKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW 1372
Query: 667 -------TFIGLDKMAVWAKKMTE-IQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVA 718
+++ KK+ + +Q E + EK +Q + D +V
Sbjct: 1373 RTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMV- 1431
Query: 719 DNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNK 778
++++A +A D++ R +++ + T ++ + S + E+ K
Sbjct: 1432 -DVERANSLAAALDKKQRNF---DKVLAEWKTKCEESQAELEASLKESRSL---STELFK 1484
Query: 779 MESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQ 838
+++ + + ++ + LE+ + L E T+ + S +++ ++ + +
Sbjct: 1485 LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLA 1544
Query: 839 VKELEANVLATAPDKKKQKLLEENVSAFKTEYD-AVAEKAGKVEAEVKRLHNTIVEINNH 897
++E EA A ++ K ++ ++ K+E D +AEK ++E ++KR + VE
Sbjct: 1545 LEEAEA---ALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIE-QLKRNYQRTVETMQS 1600
Query: 898 KLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDD 957
L A+ ++ + + + + ++ + A+R + + + ++KDT+ +DD
Sbjct: 1601 ALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDD 1660
Query: 958 LTAELKSLEDKAAEVVKNTNAAEESLPEI-----QKEHRNLLQELKVIQENE-----HAL 1007
+ L+++ A V + N + + E+ Q E L E +++ NE H
Sbjct: 1661 ALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQ 1720
Query: 1008 QKDALSIKLKLE 1019
+ K KLE
Sbjct: 1721 NTSLIHTKKKLE 1732
Score = 90.1 bits (222), Expect = 1e-17
Identities = 136/759 (17%), Positives = 320/759 (42%), Gaps = 83/759 (10%)
Query: 282 GEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQK 341
GE+++ ++ V+++ + + E + I+ L+ E K + L+ +++E +
Sbjct: 1205 GEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKN 1264
Query: 342 EKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITK----FIEENKEKFTQLDLED 397
E+I E+ + + L E ++ +++ E ++++++ F ++ +E QL+ E+
Sbjct: 1265 EEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLE-EE 1323
Query: 398 VQVREKLKHATSKAKK----LEKQLQKDKEKVEEFKSIPAKSNNIINETTTR--NNALEK 451
+ + L HA ++ L +Q ++++E E + +K+N+ + + T+ +A+++
Sbjct: 1324 NKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQR 1383
Query: 452 EKEKEEKKLK---------EVMDSLKQETQGLQKEKE---------------------SR 481
+E EE K K E ++++ + L+K K+ +
Sbjct: 1384 TEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAAL 1443
Query: 482 EKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAI 541
+K+ F K + E ++K + +Q+EL+ L + ++L K K A A + L+ K
Sbjct: 1444 DKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKREN 1503
Query: 542 RDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLD 601
+++E ++ +++ E K + +L + + D+ +EEA+++L ++ +
Sbjct: 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 1563
Query: 602 AIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVV---DSIDIAQECVNFL 658
+ + KS I + ++ + Y + + ALD V ++I + ++ L
Sbjct: 1564 LELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDL 1623
Query: 659 KRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVA 718
I ++ + + + Q + L D ++ +++ Q R L+
Sbjct: 1624 NEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQ 1683
Query: 719 DNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEIS---EEE 775
+++ Q +R ++ + + +V ++ +I E +
Sbjct: 1684 AEVEELRATLEQTERARKLAEQE---------LLDSNERVQLLHTQNTSLIHTKKKLETD 1734
Query: 776 VNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYL 835
+ +++S++++ S+ A EE+ K M L+K + L ++ L
Sbjct: 1735 LMQLQSEVEDASRDARNA-------EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1787
Query: 836 NVQVKEL-----EANVLATAPDKKKQKLLEENVSAFKTEYDAVAEK-------AGKVEAE 883
VK+L EA LA KK+ + LE + + E + +K K E
Sbjct: 1788 EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERR 1847
Query: 884 VKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLR 943
VK L E + L+ Q D +DK+ ++ S +A+ A + A+ +L K + +
Sbjct: 1848 VKELTYQSEEDRKNVLRLQ-DLVDKLQVKV---KSYKRQAEEADEQANAHLTKFR----K 1899
Query: 944 TEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEES 982
+ E+++ E+ D +++ L K + + ES
Sbjct: 1900 AQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHES 1938
Score = 64.3 bits (155), Expect = 7e-10
Identities = 76/377 (20%), Positives = 174/377 (46%), Gaps = 44/377 (11%)
Query: 772 SEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQ 831
+E+E+ M+ + Q + + + ++ +LEE++V L + +++ ++ A + L++
Sbjct: 846 TEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQ---AESENLLDA 902
Query: 832 EEYLNVQVK---ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLH 888
EE + +K +LEA + + ++ + ++A K + + ++ +++ ++ L
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLE---DECSELKKDIDDLE 959
Query: 889 NTIVEINNHKLKAQQDKLDKINKQ---LDECASAITKAQVAIKTADR----NLQKAQDSV 941
T+ ++ K A ++K+ + ++ LDE + +T+ + A++ A + +LQ +D V
Sbjct: 960 LTLAKVEKEK-HATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKV 1018
Query: 942 LRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQ 1001
K E++V+DL + L+ ++K V ++++ R L +LK+ Q
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLE--QEKKLRV------------DLERNKRKLEGDLKLAQ 1064
Query: 1002 ENEHALQKDALSIKLKLEQIDGHIAEHNSKIK-------YWHKEISKISLHPIEDNPIEE 1054
E+ L+ D + +L++ D + SK++ + K+I ++ IE+ EE
Sbjct: 1065 ESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQAR-IEELE-EE 1122
Query: 1055 ISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEEL-YLQRVAELDKI 1113
I + K ++ L R E E KK E +L+ +L++
Sbjct: 1123 IEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEA 1182
Query: 1114 TYERDSFRQAYEDLRKQ 1130
T + ++ A LRK+
Sbjct: 1183 TLQHEAMVAA---LRKK 1196
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 105 bits (261), Expect = 4e-22
Identities = 166/890 (18%), Positives = 364/890 (40%), Gaps = 96/890 (10%)
Query: 286 NRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIH 345
NR+ +E + L EK E L E E+ + EL+ R+ + + E+I
Sbjct: 866 NRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAE--------ELRARLTAKKQELEEIC 917
Query: 346 ED----TKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVR 401
D +E E+ L E K +++++ E++L EE + +L LE V
Sbjct: 918 HDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL-------EEEESARQKLQLEKVTTE 970
Query: 402 EKLKHATSKAKKLEKQ---LQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEK 458
KLK + LE Q L K+K+ +E+ A+ + E ++ +L K K K E
Sbjct: 971 AKLKKLEEEQIILEDQNCKLAKEKKLLED---RIAEFTTNLTEEEEKSKSLAKLKNKHEA 1027
Query: 459 KLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVS 518
+ ++ + L++E + Q+ +++R K L G S +++ +++ +EL +
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRK-LEGDSTDLSDQIAELQAQIAELKM---------- 1076
Query: 519 QLTKAKEALIAASETLKERKA-------AIRDIEGKLPQTEQELKEKEKELQKLTQEETN 571
QL K +E L AA ++E A IR++E ++ + +++L+ + K +++ +
Sbjct: 1077 QLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRD 1136
Query: 572 FKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDV 631
+ L ++E+ S A + + + K + + +K+
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ 1196
Query: 632 AISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTP 691
A+ L+ ++ ++ L+ + +A + K+ + K +E + +
Sbjct: 1197 AVEELAEQLEQTKRVKANL-EKAKQTLENERGELANEV---KVLLQGKGDSEHKRKKVEA 1252
Query: 692 RLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVT-----LQGQIIE 746
+L +L +E R A + T + LD T + Q D + +T L+ Q+ +
Sbjct: 1253 QLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD 1312
Query: 747 QSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVK 806
+ + + ++ S ++ E+E N QL+ + +E K LE+++
Sbjct: 1313 TQELL----QEENRQKLSLSTKLKQVEDEKNSFREQLEEE-------EEAKHNLEKQIAT 1361
Query: 807 LRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKEL----EANVLATAPDKKKQKLLEEN 862
L +M+ +E ++ E + L ++ L E V A +K + L++
Sbjct: 1362 LHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQE 1421
Query: 863 VSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITK 922
+ + D + A +E + K+ + E K +++ D + +
Sbjct: 1422 LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEER--------DRAEAEARE 1473
Query: 923 AQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEES 982
+ + R L++A + E+ K E++DL + + E+ K+ A E+
Sbjct: 1474 KETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533
Query: 983 LPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQ-IDGHIAEHNSKIKYWHKEISK 1041
+ E++ + L EL+ ++ + L+ + ++K + E+ + G + K K +++ +
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVRE 1593
Query: 1042 ISLHPIEDNPIEEISVLSPEDLE------------AIKNPDSITNQIALLEARCHEMKPN 1089
+ ++ ++V + + LE A KN D Q+ L+A+ +
Sbjct: 1594 MEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRE 1653
Query: 1090 LG--------AIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQR 1131
L +A+ K+ E+ AE+ ++ E + +A +++R
Sbjct: 1654 LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQER 1703
Score = 99.8 bits (247), Expect = 2e-20
Identities = 155/815 (19%), Positives = 340/815 (41%), Gaps = 101/815 (12%)
Query: 234 QIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEK 293
QI M+ K H + + E E + R+ ++ + + L RGE N VK++ +
Sbjct: 1186 QIQEMRQK----HSQAVEELAEQLEQTKRVKANLE---KAKQTLENERGELANEVKVLLQ 1238
Query: 294 EK-DALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEIN 352
K D+ K + + L+ + F + V EL ++ +++ + + + + +
Sbjct: 1239 GKGDSEHKRKKVEAQLQELQVK-FNEGERVRT----ELADKVTKLQVELDNVTGLLSQSD 1293
Query: 353 EKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFT------QLDLEDVQVREKLKH 406
KS+ L+ + A ++DT++ L EEN++K + Q++ E RE+L+
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQ------EENRQKLSLSTKLKQVEDEKNSFREQLEE 1347
Query: 407 ATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDS 466
LEKQ+ +V + K S + L+K+ E ++ +E + +
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAA 1407
Query: 467 LKQETQGLQKEKESREKELMGFSKSVNEARSK---MDVAQSELDIYLSRHNTAVSQLTKA 523
+ L+K K ++EL ++ R ++ Q + D L+ T ++ +
Sbjct: 1408 YDK----LEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE 1463
Query: 524 KEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKV 583
++ A + KE KA L + +E E++ EL++L ++ F++ + DL
Sbjct: 1464 RDRAEAEARE-KETKAL------SLARALEEAMEQKAELERLNKQ---FRTEMEDLMSSK 1513
Query: 584 EEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYI 643
++ S+ + L+ ++E K+ ++ + L + +V + + +
Sbjct: 1514 DDVGKSVHELEKSKRALEQQVEEMKT-QLEELEDELQATEDAKLRLEVNLQAMKAQFERD 1572
Query: 644 VVDSIDIAQECVNFLKRQNIGVATFIGLDK----MAVWAKKMTEIQTPENTPRLFDLVKV 699
+ + ++E L RQ + + ++ MAV A+K E+ + + K
Sbjct: 1573 LQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKN 1632
Query: 700 KDEKIRQA--FYFALRDTLVADNLDQATR---VAYQKDRRWRVVTLQGQIIEQSGTMTGG 754
+DE I+Q ++D + + +A+R +A K+ ++ +++ ++I+ +
Sbjct: 1633 RDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAA 1692
Query: 755 GSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREM 814
+ +++E +++ ++ N S K E+K +LE R+ +L E
Sbjct: 1693 ERAKRQ-----------AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE 1741
Query: 815 RNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA 874
+ E +++ Q + +N + ++ A + +Q+L +N
Sbjct: 1742 QGNTELINDRLKKANLQIDQINTDLNLERSH--AQKNENARQQLERQNK----------- 1788
Query: 875 EKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNL 934
+++ +++ + T+ + A + K+ ++ +QLD +T +R
Sbjct: 1789 ----ELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDN------------ETKER-- 1830
Query: 935 QKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKA-------AEVVKNTNAAEESLPEIQ 987
Q A V RTEK++KD +VDD + +D+A ++ + AEE
Sbjct: 1831 QAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRAN 1890
Query: 988 KEHRNLLQELKVIQENEHALQKDALSIKLKLEQID 1022
R L +EL+ E A+ ++ S+K KL + D
Sbjct: 1891 ASRRKLQRELEDATETADAMNREVSSLKNKLRRGD 1925
Score = 98.2 bits (243), Expect = 4e-20
Identities = 181/876 (20%), Positives = 353/876 (40%), Gaps = 150/876 (17%)
Query: 287 RVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHE 346
+ ++ E + + E+ + +E E +K ++ I EL+ +I+E++ E
Sbjct: 1068 QAQIAELKMQLAKKEEELQAALARVEEEAAQK--NMALKKIRELESQISELQEDLESERA 1125
Query: 347 DTKEINEKSNILSNEMKAKNKDVKDT--------------EKKLNKITKFIEE----NKE 388
+ ++ L E++A +++DT E+++N + K +EE ++
Sbjct: 1126 SRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEA 1185
Query: 389 KFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNA 448
+ ++ + Q E+L + K+++ L+K K+ +E N E
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLE----------NERGELANEVKV 1235
Query: 449 LEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDI 508
L + K E K K+V L QE Q E E EL + +K+ V +
Sbjct: 1236 LLQGKGDSEHKRKKVEAQL-QELQVKFNEGERVRTELA-------DKVTKLQVELDNVTG 1287
Query: 509 YLSRHNTAVSQLTKAKEALIA----ASETLKERKAAIRDIEGKLPQTEQELKEKEKELQK 564
LS+ ++ S+LTK AL + E L+E + KL Q E E ++L++
Sbjct: 1288 LLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE 1347
Query: 565 LTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDA-IIQEKKSGRIPGIYGRLGDLG 623
+ + N + + L +V + K M S G + A ++ K + G+ R +
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKK--MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKV 1405
Query: 624 AIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTE 683
A +K + + LD ++VD Q N K+Q KK +
Sbjct: 1406 AAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ-----------------KKFDQ 1448
Query: 684 IQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQ 743
+ + +EK A Y RD A+ ++ T+ + +
Sbjct: 1449 L--------------LAEEKTISAKYAEERDRAEAEAREKETKAL-------SLARALEE 1487
Query: 744 IIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAM--QIQEQKVQLE 801
+EQ + ++ K + S+++V K +L+ SK+A+ Q++E K QLE
Sbjct: 1488 AMEQKAEL----ERLNKQFRTEMEDLMSSKDDVGKSVHELEK-SKRALEQQVEEMKTQLE 1542
Query: 802 ERVVKLRHSE---REMRNTLEKFTASIQRLI--------EQEEYLNVQVKELEANVLATA 850
E +L+ +E + L+ A +R + E+++ L QV+E+EA +
Sbjct: 1543 ELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL---- 1598
Query: 851 PDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKIN 910
D++KQ+ + AVA + K+E ++K L + +D N
Sbjct: 1599 EDERKQRSM------------AVAARK-KLEMDLKDL---------------EAHIDSAN 1630
Query: 911 KQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAA 970
K DE + K Q +K R L + S + K+ EK++ + AE+ L+++ A
Sbjct: 1631 KNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELA 1690
Query: 971 EVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNS 1030
+ A++ E+ E N + + E + L+ ++ +LE+ G+ N
Sbjct: 1691 AAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELIND 1750
Query: 1031 KIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDS---ITNQIALLEARCHEMK 1087
++K + +I +I+ + L+ E A KN ++ + Q L+ + EM+
Sbjct: 1751 RLKKANLQIDQIN------------TDLNLERSHAQKNENARQQLERQNKELKVKLQEME 1798
Query: 1088 PNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQA 1123
+ ++YK ++A+L++ RQA
Sbjct: 1799 GTVK--SKYKASITALEAKIAQLEEQLDNETKERQA 1832
Score = 74.3 bits (181), Expect = 7e-13
Identities = 141/689 (20%), Positives = 297/689 (43%), Gaps = 94/689 (13%)
Query: 459 KLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVS 518
K+K ++ +QE +E ++E+EL+ + A +++ ++ L L +
Sbjct: 833 KVKPLLQVSRQE-----EEMMAKEEELVKVREKQLAAENRLTEMET-LQSQLMAEKLQLQ 886
Query: 519 QLTKAKEALIAASETLKERKAAIR-DIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVH 577
+ +A+ L A +E L+ R A + ++E E ++E+E+ Q L E+ + +
Sbjct: 887 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946
Query: 578 DLFQKVEEAKSSLAMNRSRGKV-LDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSC 636
+L +++EE +S +R K+ L+ + E K ++ +E+ + +C
Sbjct: 947 ELEEQLEEEES------ARQKLQLEKVTTEAKLKKLE------------EEQIILEDQNC 988
Query: 637 CHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDL 696
A + +++ IA+ N + + K K E + RL
Sbjct: 989 KLAKEKKLLED-RIAEFTTNLTEEEE--------KSKSLAKLKNKHEAMITDLEERL--- 1036
Query: 697 VKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGS 756
++EK RQ R L D+ D + ++A + + ++ L+ Q+ ++ + +
Sbjct: 1037 --RREEKQRQELE-KTRRKLEGDSTDLSDQIA---ELQAQIAELKMQLAKKEEELQAALA 1090
Query: 757 KVMKGRMGSSLV---IEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSERE 813
+V + ++ I E ++++++ L+++ + ++QK L E + L+ E
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALK---TE 1147
Query: 814 MRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAV 873
+ +TL+ A + ++E+ +N+ K LE A + + Q++ +++ A + E
Sbjct: 1148 LEDTLDSTAAQQELRSKREQEVNILKKTLEEE--AKTHEAQIQEMRQKHSQAVE-ELAEQ 1204
Query: 874 AEKAGKVEAEVKR----LHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKT 929
E+ +V+A +++ L N E+ N Q K D +K+ + + + + QV
Sbjct: 1205 LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKR-KKVEAQLQELQVKFNE 1263
Query: 930 ADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKE 989
+R + D V + + E+ D++T L + K++++ K+ +A E L + Q+
Sbjct: 1264 GERVRTELADKVTKLQVEL-------DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQE- 1315
Query: 990 HRNLLQELKVIQENEHALQKDALSIKLKLEQIDG-------HIAEHNSKIKYWHKEISKI 1042
LLQE EN + LS+ KL+Q++ + E K+I+ +
Sbjct: 1316 ---LLQE-----EN-----RQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362
Query: 1043 SLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEEL 1102
+ E SV E E +K + + L R HE K +A Y K E+
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKR--KLQKDLEGLSQR-HEEK-----VAAYDKLEKT 1414
Query: 1103 YLQRVAELDKITYERDSFRQAYEDLRKQR 1131
+ ELD + + D RQ+ +L K++
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443
Score = 56.2 bits (134), Expect = 2e-07
Identities = 98/534 (18%), Positives = 225/534 (42%), Gaps = 44/534 (8%)
Query: 615 IYGRLGDLGAIDEKYDVAIS-------SCCHALDYIVVDSIDIAQECVNFLKRQNIGVAT 667
++ R G L ++E+ D+ I+ +CC Y+ + Q+ + +K A
Sbjct: 761 VFFRAGVLAHLEEERDLKITDVIIGFQACCRG--YLARKAFAKRQQQLTAMKVLQRNCAA 818
Query: 668 FIGLDKMAVW-----AKKMTEI--QTPENTPRLFDLVKVKDEKI----RQAFYFALRDTL 716
++ L W K + ++ Q E + +LVKV+++++ R L+ L
Sbjct: 819 YLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQL 878
Query: 717 VADNLDQATRV-------AYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVI 769
+A+ L ++ A ++ R R+ + ++ E + + +
Sbjct: 879 MAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEK 938
Query: 770 EISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLI 829
+ ++ + ++E QL+ + ++Q +KV E ++ KL + + + K A ++L+
Sbjct: 939 KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKL-AKEKKLL 997
Query: 830 EQ---EEYLNVQVKELEANVLATAPDKKKQKL--LEENVSAFKTEYDAVAEKAGKVEAEV 884
E E N+ +E ++ LA +K + + LEE + + + + + K+E +
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 885 KRLHNTIVEIN------NHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQ 938
L + I E+ +L ++++L +++E A+ A I+ + + + Q
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117
Query: 939 DSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELK 998
+ + EK+ DL EL++L+ + + + +T AA++ L +++ N+L+ K
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDST-AAQQELRSKREQEVNILK--K 1174
Query: 999 VIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIK--YWHKEISKISLHPIEDNPIEEIS 1056
++E + ++ K Q +AE + K + E +K +L E+
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234
Query: 1057 VLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAEL 1110
VL ++ + Q+ L+ + +E + +A+ K ++ L V L
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGL 1288
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 103 bits (257), Expect = 1e-21
Identities = 203/1026 (19%), Positives = 424/1026 (41%), Gaps = 171/1026 (16%)
Query: 228 LQGEVEQIAMMKPKGQTEHDEGMLEYLED--IIGCGRLNE---PIKVLCRRVEILNEHRG 282
+Q ++ +I +K + ++ E LE++E + +LNE +K + + ++L E +
Sbjct: 1153 MQKKINEIENLK--NELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQ- 1209
Query: 283 EKLNRVKMVEKEKDALEGE-KNIAIEFLTLENEIFRKKNHVCQYY--IYELQKRIAE--- 336
K E E+D L G + I L + E+ H+ ++ I EL++ ++E
Sbjct: 1210 ------KSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTA 1263
Query: 337 -------METQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEK 389
+E K+ E+ ++E+ +L N K+V +T++ +N++ E++ K
Sbjct: 1264 QIINTQDLEKSHTKLQEEIPVLHEEQELLPNV-----KEVSETQETMNELELLTEQSTTK 1318
Query: 390 ----FTQLDLEDVQVREKLKHATSKAKKLEKQ---------------------LQKDKEK 424
++++E +++ EK + + + K L K+ +++ K
Sbjct: 1319 DSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAK 1378
Query: 425 VEEFKSIPAKSNNII---NETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESR 481
++E +S +S N+ NETT + +E+ K K+ L+ ++ E GL K +
Sbjct: 1379 IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR-----IEIEMLGLSKRLQES 1433
Query: 482 EKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAI 541
E+ +K ++ + +V QSE D V++ + +E L A LKE++ I
Sbjct: 1434 HDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETI 1493
Query: 542 RDIEGKLPQTEQELKEKEKELQKLT-------------QEETNFKSLVHDLFQKVEEAKS 588
++ L + E E+ +K+L+ + +E+ N K + ++ +KV E K
Sbjct: 1494 NELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQ-ISEVQEKVNELKQ 1552
Query: 589 SLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSI 648
+++ L +I E K + + I K + AL
Sbjct: 1553 FKEHRKAKDSALQSI--ESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLK 1610
Query: 649 DIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAF 708
+ +E V +K F+ + + +KM EI E+ F+ K+ E I
Sbjct: 1611 ENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEI---EHLKEQFETQKLNLENIE--- 1664
Query: 709 YFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLV 768
+N+ + T++ ++ R VT K R V
Sbjct: 1665 ---------TENI-RLTQILHENLEEMRSVT--------------------KERDDLRSV 1694
Query: 769 IEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSE-REMRNTLEKFTASIQR 827
E + E ++++ L+ + ++ QE+ +K+ H +E + T++K +
Sbjct: 1695 EETLKVERDQLKENLRETITRDLEKQEE--------LKIVHMHLKEHQETIDKLRGIVSE 1746
Query: 828 LIEQEEYLNVQVKELE-ANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKR 886
+ E N+Q K+LE +N A D K Q+ L K + + + + G V + +
Sbjct: 1747 --KTNEISNMQ-KDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDK 1803
Query: 887 LHNTIVEINN---------HKLKAQQDKLDKINKQLDEC---ASAITKAQVAIKTADRNL 934
L N ++ N +LKA + +L + K ++E S + + + IK L
Sbjct: 1804 LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTL 1863
Query: 935 QKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLL 994
K + L +++ + +E+ + E +L + + +ESL E + +
Sbjct: 1864 SKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQ 1923
Query: 995 QELKVIQ--ENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPI 1052
QELK + EH D L K I+E +I K++ K +D
Sbjct: 1924 QELKTARMLSKEHKETVDKLREK---------ISEKTIQISDIQKDLDK-----SKDELQ 1969
Query: 1053 EEISVLSPEDLEAIKNPDSIT------NQIALLEARCHEMKPNLGAIA--EYKKKEELYL 1104
++I L ++L+ ++ + + N++ L+ + ++ ++ ++ ++L+
Sbjct: 1970 KKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLH- 2028
Query: 1105 QRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQM---LTLGGDAEL 1161
+ + E+ + ERD R+ E L+ +R ++F+A + + ++N+Q+ L D +
Sbjct: 2029 ESLEEIRIVAKERDELRRIKESLKMER-DQFIATLREMIARDRQNHQVKPEKRLLSDGQQ 2087
Query: 1162 ELVDSL 1167
L +SL
Sbjct: 2088 HLTESL 2093
Score = 102 bits (254), Expect = 2e-21
Identities = 165/875 (18%), Positives = 365/875 (41%), Gaps = 94/875 (10%)
Query: 202 KKKTFKDVGNLLRSHGIDLDHNRFL----ILQGEVEQIAMMKPKGQTEHDEGMLEYLEDI 257
++ + ++ + ++ H + +L E E + +K +T+ LE L +
Sbjct: 1255 RRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQ 1314
Query: 258 IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFR 317
++ R+ LNE E +K + KE+D L+ K E L ++++ +
Sbjct: 1315 STTKDSTTLARIEMERLR-LNEKFQESQEEIKSLTKERDNLKTIK----EALEVKHDQLK 1369
Query: 318 KKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNI---------LSNEMKAKNKD 368
+ I E Q + + KEK +E TK ++E + EM +K
Sbjct: 1370 EHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKR 1429
Query: 369 VKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKD----KEK 424
++++ ++ + K ++ + L E Q++E +K +K + E++L+ KE+
Sbjct: 1430 LQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ 1489
Query: 425 VEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREK- 483
E + + E +T LE +K + K++E+ + K+E +++ E +EK
Sbjct: 1490 EETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYE--KEEQFNIKQISEVQEKV 1547
Query: 484 -ELMGFS---KSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKA 539
EL F K+ + A ++ EL L + + K KE + E L+ +
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERD 1607
Query: 540 AIRDIEGKLPQTEQELKEKEKELQKLTQ-EETNFKSL-VHDLFQKVEEAKSSLAMNRSRG 597
+++ ++ +E +EKE + K+T ET K + L ++ E K +L +
Sbjct: 1608 QLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETEN 1667
Query: 598 KVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQEC--- 654
L I+ E + + DL +++E V L + ++ +E
Sbjct: 1668 IRLTQILHENLE-EMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIV 1726
Query: 655 -VNFLKRQNIGVATFIGLDKM-AVWAKKMTEIQT-PENTPRLFDLVKVKDEKIRQAFYFA 711
++ + Q +DK+ + ++K EI ++ D +K +D KI++
Sbjct: 1727 HMHLKEHQET-------IDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEEL--- 1776
Query: 712 LRDTLVADNLDQATRVAYQ--KDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVI 769
R+A+ K+++ + L+G + E++ + S + K S+ +
Sbjct: 1777 --------------RIAHMHLKEQQETIDKLRGIVSEKTDKL----SNMQKDLENSNAKL 1818
Query: 770 EISEEEVNKMESQL-------QNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFT 822
+ +E+ E QL KK ++++ K Q++++ + L E E N
Sbjct: 1819 QEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNL----- 1873
Query: 823 ASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEA 882
Q+L E E + +KE + K ++ L+E++ K D ++ K
Sbjct: 1874 --AQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKAR-DLEIQQELKTAR 1930
Query: 883 EVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVL 942
+ + H V+ K+ + ++ I K LD K++ ++ + LQK + +L
Sbjct: 1931 MLSKEHKETVDKLREKISEKTIQISDIQKDLD-------KSKDELQKKIQELQKKELQLL 1983
Query: 943 RTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQE 1002
R ++++ + K+++++ K E A+ + + ++ +K H + L+E++++ +
Sbjct: 1984 RVKEDVNMSHKKINEMEQLKKQFE---AQNLSMQSVRMDNFQLTKKLHES-LEEIRIVAK 2039
Query: 1003 NEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHK 1037
L++ S+K++ +Q + E ++ + H+
Sbjct: 2040 ERDELRRIKESLKMERDQFIATLREMIARDRQNHQ 2074
Score = 97.1 bits (240), Expect = 1e-19
Identities = 188/1014 (18%), Positives = 414/1014 (40%), Gaps = 194/1014 (19%)
Query: 284 KLNRVKMVEKEKDALEGE-KNIAIEFLTLENEI------FRKKNHVCQYYIYELQKRIAE 336
KL + +E E ++L + N+ +++ L E ++KN + ++ E +R +
Sbjct: 489 KLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEF---EALERKTK 545
Query: 337 METQKEKIHE--DTKEINEKSNI----LSNEMKAKNKDVKDTEKKLNKITKFIEENKEKF 390
+ + + IHE + K + + + + L NE+ +K + +++ E ++ K+ ++I+ K +
Sbjct: 546 KDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLEN 605
Query: 391 TQLDL------------------------------------EDVQVREKLKHATSKAKKL 414
++DL E+++++EK+K + K++
Sbjct: 606 IKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQM 665
Query: 415 EKQLQ--------KDKEKVEEFKSIPAKSNNIINET---------------------TTR 445
E +Q K K +V+ K + + N I T T
Sbjct: 666 ENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDL 725
Query: 446 NNALEKEKEKEEKKLKEV-----MDSLKQETQGLQKEKESREKEL--------MGFSKSV 492
L KE E+ E +EV + SL E + L+KE + + +EL FS+ V
Sbjct: 726 QKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVV 785
Query: 493 NE-----------ARSKMDVAQSELDI----------------YLSRHNTAVSQLTKAKE 525
++ ++K D+A ++ + + ++ + + + +
Sbjct: 786 HKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ 845
Query: 526 ALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNF------------- 572
++ S+ ++ +++ ++ +L QEL+EK +E+Q+ E
Sbjct: 846 EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQT 905
Query: 573 ----KSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEK 628
K+L+ + Q+ E +L + K L +Q ++ I+ + E+
Sbjct: 906 VEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQ 965
Query: 629 YDVAISSCCHALDYIVVDSIDIAQECV-NFLKRQNIGVA------TFIGLDKMAVWAKKM 681
A+ S + I I++E N +N G +G+DK K
Sbjct: 966 LRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKN 1025
Query: 682 TEIQTP--------ENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDR 733
T+ T E ++F L++ K+E + + +L + + +
Sbjct: 1026 TQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQE 1085
Query: 734 RWRVVTLQGQIIEQSGTMTGGGSKVMK--GRMGSSL--VIEISEEEVNKMESQLQNDSKK 789
R+ L ++ +Q + + +K G + + + E+ EE++ + QLQ ++
Sbjct: 1086 ELRL--LGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEV-EEKLKEKSQQLQEKQQQ 1142
Query: 790 AMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLAT 849
+ +QE+ ++++++ ++ + + E++N +E + LN +E+++
Sbjct: 1143 LLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT--- 1199
Query: 850 APDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKI 909
K++K+L+E +F+TE D + ++EA + + +I + LK Q+ +D++
Sbjct: 1200 ----KERKVLKELQKSFETERDHLRGYIREIEATGLQTKEEL-KIAHIHLKEHQETIDEL 1254
Query: 910 NKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKA 969
+ + E + I Q ++ + LQ+ + VL E+E+ KEV + + LE
Sbjct: 1255 RRSVSEKTAQIINTQ-DLEKSHTKLQE-EIPVLHEEQELLPNVKEVSETQETMNELE--- 1309
Query: 970 AEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIK-------LKLEQID 1022
++T +L I+ E L ++ + QE +L K+ ++K +K +Q+
Sbjct: 1310 LLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLK 1369
Query: 1023 GHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIAL---- 1078
HI E +KI+ + + +DN +I ++E K DS +I +
Sbjct: 1370 EHIRETLAKIQESQSKQEQSLNMKEKDNETTKI----VSEMEQFKPKDSALLRIEIEMLG 1425
Query: 1079 LEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRL 1132
L R E + ++A KE+ LQR+ E+ + E D ++ +++ + L
Sbjct: 1426 LSKRLQESHDEMKSVA----KEKDDLQRLQEV--LQSESDQLKENIKEIVAKHL 1473
Score = 84.0 bits (206), Expect = 9e-16
Identities = 172/914 (18%), Positives = 376/914 (41%), Gaps = 131/914 (14%)
Query: 270 LCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYE 329
L + + L E E R+ +E+ K+ LE + TL+ + R+K + + +
Sbjct: 868 LSYKTQELQEKTREVQERLNEMEQLKEQLENRDS------TLQT-VEREKTLITE----K 916
Query: 330 LQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVK----DTEKKLNKITKFIEE 385
LQ+ + E++T ++ +D K++ E I +++K+ D DT+++L + +++
Sbjct: 917 LQQTLEEVKTLTQE-KDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQ 975
Query: 386 NKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTR 445
++E L + + + H + + + Q+ +++ + + AK+ +
Sbjct: 976 HQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKD 1035
Query: 446 NNALEKEKE-----KEEKKLKEVMDSLKQETQGLQKE-KESREKELMGFSKSVNEARSKM 499
N +E++++ +E+ +L+++++S+ E + L+ + KE+ E + ++ E R
Sbjct: 1036 NEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTI----ENQEELRLLG 1091
Query: 500 DVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKE 559
D + + +I N A+ K + L + L E +E KL + Q+L+EK+
Sbjct: 1092 DELKKQQEIVAQEKNHAI----KKEGELSRTCDRLAE-------VEEKLKEKSQQLQEKQ 1140
Query: 560 KELQKLTQEETNFKSLVHDLFQKVEEAKS-SLAMNRSRGKVLDAIIQEKKSGRIPGIYGR 618
++L + +E + + ++++ E K+ L + + L+ + +K + +
Sbjct: 1141 QQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLE--LAQKLNENYEEVKSI 1198
Query: 619 LGDLGAIDEKYDVAISSCCHALDYI---------VVDSIDIA-------QECVNFLKRQ- 661
+ + E + H YI + + IA QE ++ L+R
Sbjct: 1199 TKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSV 1258
Query: 662 NIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFD----LVKVKDEKIRQAFYFALRDTLV 717
+ A I + K T++Q E P L + L VK+ Q L
Sbjct: 1259 SEKTAQIINTQDL---EKSHTKLQ--EEIPVLHEEQELLPNVKEVSETQETMNELELLTE 1313
Query: 718 ADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVN 777
+T +A + R R+ + E+ ++T + + + + +E +
Sbjct: 1314 QSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIR 1373
Query: 778 KMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNV 837
+ +++Q K QEQ + ++E+ + EM K +A ++ IE L+
Sbjct: 1374 ETLAKIQESQSK----QEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLG-LSK 1428
Query: 838 QVKELEANVLATAPDK----KKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVE 893
+++E + + A +K + Q++L+ K + K + E E+K H
Sbjct: 1429 RLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCC--- 1485
Query: 894 INNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTE-----KEI 948
LK Q++ ++++ L E + I+ Q ++ + LQ + E K+I
Sbjct: 1486 -----LKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQI 1540
Query: 949 KDTEKEVDDL----------TAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELK 998
+ +++V++L + L+S+E K E+ TN +ES EIQ +++E +
Sbjct: 1541 SEVQEKVNELKQFKEHRKAKDSALQSIESKMLEL---TNRLQESQEEIQ----IMIKEKE 1593
Query: 999 VIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVL 1058
++ + ALQ + +K ++I + E K + K
Sbjct: 1594 EMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLK--------------------- 1632
Query: 1059 SPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAI-AEYKKKEELYLQRVAELDKITYER 1117
+ A+ +I L+ + K NL I E + ++ + + E+ +T ER
Sbjct: 1633 ----MTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKER 1688
Query: 1118 DSFRQAYEDLRKQR 1131
D R E L+ +R
Sbjct: 1689 DDLRSVEETLKVER 1702
Score = 73.6 bits (179), Expect = 1e-12
Identities = 145/800 (18%), Positives = 343/800 (42%), Gaps = 120/800 (15%)
Query: 276 ILNEHRGEKLNRVKMVEKEKDALEG-------EKNIAIEFLTLENEIFRKKNHVCQYYIY 328
I++E E N K +E DAL+ E IA L + E K +
Sbjct: 1743 IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTD 1802
Query: 329 ELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKE 388
+L ++E K+ E +E+ K+N +++ KDV +T+KK++++ + ++ K+
Sbjct: 1803 KLSNMQKDLENSNAKLQEKIQEL--KAN--EHQLITLKKDVNETQKKVSEMEQLKKQIKD 1858
Query: 389 K---FTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTR 445
+ ++L++E++ + +KL + K + K+ + E K + + ET R
Sbjct: 1859 QSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKAR 1918
Query: 446 NNALEKEKEKEE---KKLKEVMDSLKQ-------ETQGLQKEKESREKELMGFSKSVNEA 495
+ +++E + K+ KE +D L++ + +QK+ + + EL K + E
Sbjct: 1919 DLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQ---KKIQEL 1975
Query: 496 RSK-MDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQE 554
+ K + + + + D+ +S ++++ + K+ A + +++ + + KL ++ +E
Sbjct: 1976 QKKELQLLRVKEDVNMSHKK--INEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEE 2033
Query: 555 LKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKV-------------LD 601
++ KE +L + + + K + D F + + +A +R +V L
Sbjct: 2034 IRIVAKERDELRRIKESLK-MERDQF--IATLREMIARDRQNHQVKPEKRLLSDGQQHLT 2090
Query: 602 AIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQ 661
++EK S RI + R ++ D+ Y+ C + L S+D+ +E + F K
Sbjct: 2091 ESLREKCS-RIKELLKRYSEM---DDHYE-----CLNRL------SLDLEKE-IEFQKEL 2134
Query: 662 NIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALR------DT 715
++ V + L + K E N + ++ +K++ + + ++
Sbjct: 2135 SMRVKANLSLPYLQT---KHIEKLFTANQRCSMEFHRIM-KKLKYVLSYVTKIKEEQHES 2190
Query: 716 LVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEE 775
+ +D V QK+ + ++ Q ++Q + + +K L IE ++
Sbjct: 2191 INKFEMDFIDEVEKQKE-----LLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKD 2245
Query: 776 VNKME-SQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEY 834
++ E ++ + ++ + +++ Q E + R +++N ++K R+ + +
Sbjct: 2246 FSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKEN---DRICQVNNF 2302
Query: 835 LNVQVK---------ELEANVLATAPDKKKQKLLEENVSAFK------------------ 867
N ++ E + ++ ++ + L E+N FK
Sbjct: 2303 FNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPT 2362
Query: 868 ---TEYDAVAEKAGKVEAE-VKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKA 923
+ V +A ++ E ++ L N++ E + ++ K+ K+ K+L+ I K
Sbjct: 2363 TQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMH-KESKIIKMQKELEVTNDIIAKL 2421
Query: 924 QVAIKTADRNLQKAQDSVLRTEKEI----KDTEKEVDDLTAELKSLE---DKAAEVVKNT 976
Q + +++ L+K ++++ + ++ K ++E++DL +L ++ K A+ +
Sbjct: 2422 QAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKE 2481
Query: 977 NAAEESLPEIQKEHRNLLQE 996
+A ++ E QKE LL+E
Sbjct: 2482 ISATKATVEYQKEVIRLLRE 2501
Score = 53.9 bits (128), Expect = 1e-06
Identities = 67/304 (22%), Positives = 123/304 (40%), Gaps = 46/304 (15%)
Query: 298 LEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNI 357
LE N + L+N I ++ + +CQ + + IA M ++ E E+S
Sbjct: 2272 LEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMN--------ESTEFEERSAT 2323
Query: 358 LSNEMKAKNKDVKDTEKKLNK--------------ITKFIEENKE-----KFTQLDLEDV 398
+S E + K +K+ +KL K + ++NK + TQL E +
Sbjct: 2324 ISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKI 2383
Query: 399 --------QVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALE 450
+ +E H SK K++K+L+ + + + ++ +SN + +T L+
Sbjct: 2384 RELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQ 2443
Query: 451 KEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYL 510
+ K KE ++ LK + + EK KE F K ++ ++ ++ Q E+ I L
Sbjct: 2444 DKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKE---FEKEISATKATVEY-QKEV-IRL 2498
Query: 511 SRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEK------EKELQK 564
R N SQ + + ++ K + Q + L K EKE+ K
Sbjct: 2499 LRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISK 2558
Query: 565 LTQE 568
L Q+
Sbjct: 2559 LKQQ 2562
Score = 44.3 bits (103), Expect = 8e-04
Identities = 84/496 (16%), Positives = 208/496 (41%), Gaps = 65/496 (13%)
Query: 133 RAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHFQKIIDKEGDDYEVIPNSNFYVSRTACRD 192
+ Q+++ K+L +L D + + +K + + + + NF +++
Sbjct: 1971 KIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHES 2030
Query: 193 NTSVYHISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEV----EQIAMMKPKGQTEHD- 247
+ ++ ++ + + L+ ++ ++F+ E+ Q +KP+ + D
Sbjct: 2031 LEEIRIVAKERDELRRIKESLK-----MERDQFIATLREMIARDRQNHQVKPEKRLLSDG 2085
Query: 248 -EGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKM-VEKEKD-----ALEG 300
+ + E L + C R+ E L +R +++H E LNR+ + +EKE + ++
Sbjct: 2086 QQHLTESLRE--KCSRIKE----LLKRYSEMDDHY-ECLNRLSLDLEKEIEFQKELSMRV 2138
Query: 301 EKNIAIEFLTLEN-EIFRKKNHVCQYYIYELQKRIAEM--------ETQKEKIH------ 345
+ N+++ +L ++ E N C + + K++ + E Q E I+
Sbjct: 2139 KANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDF 2198
Query: 346 ----EDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVR 401
E KE+ K L + +++++D + N + IEE + F++ + ++
Sbjct: 2199 IDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQN-MDLHIEEILKDFSESEFPSIKT- 2256
Query: 402 EKLKHATSKAKKLEKQLQK---DKEKVEEFKSIPAKSNNII----NETTTRNNALEKEKE 454
+ + S K++ + L++ + +E+ K+ K N+ I N R A+ E
Sbjct: 2257 -EFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNEST 2315
Query: 455 KEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHN 514
+ E++ + +Q+ + L+++ E K S+ Q + +++
Sbjct: 2316 EFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRA 2375
Query: 515 TAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKS 574
T QLT +E ++E + ++ + + E ++ + +KEL+ ++
Sbjct: 2376 T---QLT---------TEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQA 2423
Query: 575 LVHDLFQKVEEAKSSL 590
VH+ + +E+ K ++
Sbjct: 2424 KVHESNKCLEKTKETI 2439
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 103 bits (256), Expect = 1e-21
Identities = 155/801 (19%), Positives = 341/801 (42%), Gaps = 97/801 (12%)
Query: 273 RVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQK 332
+V+ L E + + KEK AL+ A++ L +E + K N + + + +L++
Sbjct: 976 KVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEED---KVNSLSKSKV-KLEQ 1031
Query: 333 RIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTE-------KKLNKITKFIEE 385
++ ++E E+ + ++ L ++K + + D E +KL K I +
Sbjct: 1032 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQ 1091
Query: 386 NKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKE---KVEEFKSIPAKSNNIINE- 441
K + +Q+++KLK ++ ++LE++L+ ++ KVE+ +S ++ I+E
Sbjct: 1092 QNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISER 1151
Query: 442 ------TTTRNNALEKEKEKEEKKLKEVMD--SLKQETQG--LQKEKESREKELMGFSKS 491
T+ + K++E E +K++ ++ +L+ E L+K+ EL +
Sbjct: 1152 LEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDN 1211
Query: 492 VNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQT 551
+ + K++ +SE + L + + Q+ KAK L S TL+++ R
Sbjct: 1212 LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYR--------- 1262
Query: 552 EQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGR 611
+L+E ++ L T + ++ +L +++EE K +L +RGK+ + +
Sbjct: 1263 -VKLEEAQRSLNDFTTQRAKLQTENGELARQLEE-KEALISQLTRGKL-------SYTQQ 1313
Query: 612 IPGIYGRLGDLGAIDEKYDVAISSCCHALDYI---VVDSIDIAQECVNFLKRQNIGVATF 668
+ + +L + G A+ S H D + + + E L + N
Sbjct: 1314 MEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKAN------ 1367
Query: 669 IGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVA 728
++A W K E + T L E+ ++ L+D A A +
Sbjct: 1368 ---SEVAQWRTKY-ETDAIQRTEEL--------EEAKKKLAQRLQDAEEAVEAVNAKCSS 1415
Query: 729 YQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSK 788
+K + ++ +++ + + K R ++ E +++ + +S+L++ K
Sbjct: 1416 LEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAE-WKQKYEESQSELESSQK 1474
Query: 789 KAMQIQEQKVQL----EERVVKLRHSEREMRNTLEKFTASIQRL------IEQEEYLNVQ 838
+A + + +L EE + L +RE +N E+ + ++L + + E + Q
Sbjct: 1475 EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQ 1534
Query: 839 VKELEANVLATAPDKKKQKLLEENVSAFKTEYD----------AVAEKAGKVEAEVKRLH 888
+ E+E L +A ++ + L E + + + +AEK ++E + KR H
Sbjct: 1535 L-EVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEME-QAKRNH 1592
Query: 889 NTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEI 948
+V+ L A+ +++ + + + + ++ + A+R +AQ V + +
Sbjct: 1593 QRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLL 1652
Query: 949 KDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEI-----QKEHRNLLQELKVIQEN 1003
KDT+ ++DD L++ A V + N + L E+ Q E L E ++I+ +
Sbjct: 1653 KDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETS 1712
Query: 1004 E-----HALQKDALSIKLKLE 1019
E H+ ++ K K+E
Sbjct: 1713 ERVQLLHSQNTSLINQKKKME 1733
Score = 96.3 bits (238), Expect = 2e-19
Identities = 151/882 (17%), Positives = 385/882 (43%), Gaps = 59/882 (6%)
Query: 283 EKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKE 342
E+ R+K ++ +A E + L E + + Q + + ++R ++ K
Sbjct: 856 EEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKI 915
Query: 343 KIHEDTKEINEK---SNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQ 399
++ KE+NE+ ++ E+ AK + ++D + +++ K I++ + +++ E
Sbjct: 916 QLEAKVKEMNERLEDEEEMNAELTAKKRKLED---ECSELKKDIDDLELTLAKVEKEKHA 972
Query: 400 VREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKK 459
K+K+ T + L++ + K ++ + + ++ + + + N+L K K K E++
Sbjct: 973 TENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQ 1032
Query: 460 LKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQ 519
+ ++ SL+QE + ++ + E +++L G K E+ ++ + +L+ L + ++Q
Sbjct: 1033 VDDLEGSLEQEKK-VRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQ 1091
Query: 520 L-TKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHD 578
+K ++ + A + K+ +++ + ++ + E+EL+ + K+ + ++ + +
Sbjct: 1092 QNSKIEDEQVLALQLQKK----LKENQARIEELEEELEAERTARAKVEKLRSDLSRELEE 1147
Query: 579 LFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCH 638
+ +++EEA + ++ K +A Q+ + A+ +K+ +++
Sbjct: 1148 ISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGE 1207
Query: 639 ALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMT---EIQTPENTPRLFD 695
+D + + +E F + + + K +K++ E Q E +L +
Sbjct: 1208 QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEE 1267
Query: 696 LVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDR-----RWRVVTLQGQIIEQSGT 750
+ ++ Q + +A L++ + Q R ++ L+ Q+ E+
Sbjct: 1268 AQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKA 1327
Query: 751 MTGGGSKVMKGRMGSSLVIEISEEE----------VNKMESQL-QNDSKKAMQIQEQKVQ 799
+ R L+ E EEE ++K S++ Q +K ++ +
Sbjct: 1328 KNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEE 1387
Query: 800 LEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKEL-----EANVLATAPDKK 854
LEE KL ++ +E A L + + L ++++L +N A A DKK
Sbjct: 1388 LEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1447
Query: 855 KQ---KLLEE---NVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNH------KLKAQ 902
++ K+L E ++E ++ ++A + E+ +L N E H + K
Sbjct: 1448 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNL 1507
Query: 903 QDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAEL 962
Q+++ + +QL E + + + K + + Q ++ E ++ E ++ L A+L
Sbjct: 1508 QEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKI--LRAQL 1565
Query: 963 KSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLE--- 1019
+ + K AE+ + +E + + ++ H+ ++ L+ + E + + L +K K+E
Sbjct: 1566 EFNQIK-AEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDL 1624
Query: 1020 -QIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIE-EISVLSPEDLEAIKNPDSITNQIA 1077
+++ ++ N K++ + ++D I+ + +V + +DL+ +N + +
Sbjct: 1625 NEMEIQLSHANRMAAEAQKQVKSLQ-SLLKDTQIQLDDAVRANDDLK--ENIAIVERRNN 1681
Query: 1078 LLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDS 1119
LL+A E++ + +K E L +E ++ + +++
Sbjct: 1682 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNT 1723
Score = 90.5 bits (223), Expect = 9e-18
Identities = 153/851 (17%), Positives = 351/851 (41%), Gaps = 99/851 (11%)
Query: 268 KVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQ--- 324
K+ +V L + K N+ ++ E E++ LE E+ + L +++ R+ + +
Sbjct: 1095 KIEDEQVLALQLQKKLKENQARIEELEEE-LEAERTARAKVEKLRSDLSRELEEISERLE 1153
Query: 325 -------YYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLN 377
I +KR AE + + + E T + + L + ++ + L
Sbjct: 1154 EAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQ 1213
Query: 378 KITKFIEENKEKFTQLDLEDVQVR-EKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSN 436
++ + +E+ K +F +L+L+DV E++ A + +K+ + L+ ++ E++ ++
Sbjct: 1214 RVKQKLEKEKSEF-KLELDDVTSNMEQIIKAKANLEKVSRTLE---DQANEYRVKLEEAQ 1269
Query: 437 NIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQG----------LQKEKESREKELM 486
+N+ TT+ L+ E + ++L+E + Q T+G L+++ E K
Sbjct: 1270 RSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKN 1329
Query: 487 GFSKSVNEARSKMDV----------AQSELDIYLSRHNTAVSQL-TKAKEALIAASETLK 535
+ ++ AR D+ A++EL LS+ N+ V+Q TK + I +E L+
Sbjct: 1330 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1389
Query: 536 ERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRS 595
E K + + +L E+ ++ + L + + ++ + DL VE + ++ A
Sbjct: 1390 EAK---KKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDK 1446
Query: 596 RGKVLDAIIQEKKS------GRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSID 649
+ + D I+ E K + L K A L+ ++ +
Sbjct: 1447 KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN 1506
Query: 650 IAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDL---VKVKDEKIRQ 706
+ +E + ++ G L+K+ +K E++ E L + ++ ++ KI +
Sbjct: 1507 LQEEISDLTEQLGEGGKNVHELEKV----RKQLEVEKLELQSALEEAEASLEHEEGKILR 1562
Query: 707 AF--YFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMG 764
A + ++ + ++ + K RVV ++ +V K G
Sbjct: 1563 AQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG 1622
Query: 765 SSLVIEISEEEVNKMESQLQNDSKKAMQI-QEQKVQLEERVVKLRHSEREMRNTLEKFTA 823
+EI N+M ++ Q K + ++ ++QL++ V + L++ A
Sbjct: 1623 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAV--------RANDDLKENIA 1674
Query: 824 SIQRLIEQEEYLNVQVKELEANVLATAPDKK--KQKLLE--ENVSAFKTEYDAVAEKAGK 879
++R + L +++EL A V T +K +Q+L+E E V ++ ++ + K
Sbjct: 1675 IVER---RNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKK 1731
Query: 880 VEAEVKRLHNTIVE--------------------INNHKLKAQQDK---LDKINKQLDEC 916
+E+++ +L + + E + +LK +QD L+++ K +++
Sbjct: 1732 MESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1791
Query: 917 ASAITKA-----QVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAE 971
+ Q+A+K + LQK + V E E++ +K + ++ E + E
Sbjct: 1792 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKE 1851
Query: 972 VVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSK 1031
+ T +++L +Q L ++K + ++ A + K ++ + E +
Sbjct: 1852 LTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEER 1911
Query: 1032 IKYWHKEISKI 1042
+++K+
Sbjct: 1912 ADIAESQVNKL 1922
Score = 78.2 bits (191), Expect = 5e-14
Identities = 161/811 (19%), Positives = 316/811 (38%), Gaps = 133/811 (16%)
Query: 231 EVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKM 290
+++ + +K K + E E LE L+D+ K +V E + + RVK+
Sbjct: 1208 QIDNLQRVKQKLEKEKSEFKLE-LDDVTSNMEQIIKAKANLEKVSRTLEDQANEY-RVKL 1265
Query: 291 VEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKE 350
E ++ + A L EN ++ + I +L + Q E + +E
Sbjct: 1266 EEAQRSLNDFTTQRAK--LQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEE 1323
Query: 351 INEKSNILSNEMKAKNKDV--------KDTEKKLNK---ITKFIEENKEKFTQLDLEDVQ 399
+ N L++ +++ D ++TE K ++K E + T+ + + +Q
Sbjct: 1324 EGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQ 1383
Query: 400 VREKLKHATSKAKKLEKQLQKDKEKVE----EFKSIPAKSNNIINET------TTRNNAL 449
E+L+ A KKL ++LQ +E VE + S+ + + NE R+NA
Sbjct: 1384 RTEELEEAK---KKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAA 1440
Query: 450 EKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIY 509
+K+++ +++ KQ+ + Q E ES +KE S + + ++ + + L+ +
Sbjct: 1441 AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETF 1500
Query: 510 -----------------LSRHNTAVSQLTKAKEAL----IAASETLKERKAAIRDIEGKL 548
L V +L K ++ L + L+E +A++ EGK+
Sbjct: 1501 KRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKI 1560
Query: 549 PQTEQELKEKEKELQ-KLTQEETNFKSLVHDLFQKVEEAKSSL-AMNRSRGKVLDAIIQE 606
+ + E + + E++ KL +++ + + + V+ ++SL A RSR +VL +++
Sbjct: 1561 LRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR--VKK 1618
Query: 607 KKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVA 666
K GDL ++ + A AQ+ V L+
Sbjct: 1619 KME----------GDLNEMEIQLSHANRMAAE------------AQKQVKSLQS------ 1650
Query: 667 TFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATR 726
K T+IQ L D V+ D+ R+ L+ L++
Sbjct: 1651 -----------LLKDTQIQ-------LDDAVRANDDLKENIAIVERRNNLLQAELEELRA 1692
Query: 727 VAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQND 786
V Q +R ++ + ++IE S + + +SL+ + KMES L
Sbjct: 1693 VVEQTERSRKLA--EQELIETSERVQ------LLHSQNTSLI-----NQKKKMESDLTQL 1739
Query: 787 SKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKEL---- 842
+ + ++ EE+ K M L+K + L ++ + +K+L
Sbjct: 1740 QSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL 1799
Query: 843 -EANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTI--VEINNHKL 899
EA +A KK+ + LE V E G++EAE KR ++ + + ++
Sbjct: 1800 DEAEQIALKGGKKQLQKLEAR----------VRELEGELEAEQKRNAESVKGMRKSERRI 1849
Query: 900 KAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLT 959
K + ++ K L + K Q+ +K R ++A++ + + + E+D
Sbjct: 1850 KELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD--- 1906
Query: 960 AELKSLEDKAAEVVKNTNAAEESLPEIQKEH 990
E + D A V A + QK H
Sbjct: 1907 -EAEERADIAESQVNKLRAKSRDIGAKQKMH 1936
Score = 68.6 bits (166), Expect = 4e-11
Identities = 160/779 (20%), Positives = 296/779 (37%), Gaps = 120/779 (15%)
Query: 410 KAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQ 469
K+ + EK++ KE+ K KS E K+L+E M SL Q
Sbjct: 843 KSAETEKEMATMKEEFGRIKETLEKS------------------EARRKELEEKMVSLLQ 884
Query: 470 ETQGLQKEKESREKELMGFSKSVNEA---RSKMDVAQSELDIYLSRHNTAVSQLTKAKEA 526
E LQ + ++ + L + ++ + +++ E++ L ++LT K
Sbjct: 885 EKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRK 944
Query: 527 LIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQ----- 581
L + E K I D+E L + E+E E +++ LT+E ++ L +
Sbjct: 945 L---EDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL 1001
Query: 582 -----------KVEEAKSSLAMNRSRGKV------LDAIIQEKKSGRIPGIYGRL---GD 621
+VEE K + ++++S+ K+ L+ ++++K R+ + GD
Sbjct: 1002 QEAHQQALDDLQVEEDKVN-SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD 1060
Query: 622 LGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKM 681
L E + + + DI Q+ Q + + L + +++
Sbjct: 1061 LKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEEL 1120
Query: 682 TEIQTPENTPRLFDLVKVKDEKIRQAFYFALRD-----------TLVADNLDQATRVAYQ 730
E E T R K EK+R L + T V +++ +Q
Sbjct: 1121 EEELEAERTAR------AKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1174
Query: 731 KDRR-WRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSL--VIEISEEEVNKMESQLQNDS 787
K RR TLQ + + S G +L V + E+E ++ + +L + +
Sbjct: 1175 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT 1234
Query: 788 KKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVL 847
QI + K LE+ L E R LE+ S+ Q L + EL
Sbjct: 1235 SNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGEL----- 1289
Query: 848 ATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLD 907
A ++++ L ++ K Y E + E + N + H L++ + D
Sbjct: 1290 --ARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALA----HALQSARHDCD 1343
Query: 908 KINKQLDECASAITKAQVAIKTADRNLQK-----AQDSVLRTE----------KEIKDTE 952
+ +Q +E A + Q + A+ + + D++ RTE + ++D E
Sbjct: 1344 LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1403
Query: 953 KEVDDLTAELKSLEDKAAEV----------VKNTNAAEESLPEIQKEHRNLLQELKVIQE 1002
+ V+ + A+ SLE + V+ +NAA +L + Q+ +L E K E
Sbjct: 1404 EAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE 1463
Query: 1003 NE----HALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVL 1058
+ QK+A S+ +L ++ E ++ + +E N EEIS L
Sbjct: 1464 ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE---------NKNLQEEISDL 1514
Query: 1059 SPEDLEAIKNPDSITNQIALLEARCHEMKPNL-GAIAEYKKKEELYLQRVAELDKITYE 1116
+ + E KN + LE E++ L A A + +E L+ E ++I E
Sbjct: 1515 TEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAE 1573
Score = 63.9 bits (154), Expect = 9e-10
Identities = 140/731 (19%), Positives = 300/731 (41%), Gaps = 84/731 (11%)
Query: 452 EKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLS 511
E EKE +KE +K+ + + ++ E++++ + N+ + ++ Q L+
Sbjct: 846 ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEE 905
Query: 512 RHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETN 571
R + + + + + +E L++ + ++ K + E E E +K++ L
Sbjct: 906 RCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAK 965
Query: 572 FKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDV 631
+ H KV+ +A +++ + +EKK+ + L DL ++K +
Sbjct: 966 VEKEKHATENKVKNLTEEMA---GLDEIIAKLTKEKKALQ-EAHQQALDDLQVEEDKVN- 1020
Query: 632 AISSCCHALDYIVVD---SIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPE 688
++S L+ V D S++ ++ L+R + + L + ++ + ++Q E
Sbjct: 1021 SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE 1080
Query: 689 NTPRL-FDL----VKVKDEKI-----------RQAFYFALRDTLVADNLDQATRVAYQKD 732
+ FD+ K++DE++ QA L + L A+ +A + D
Sbjct: 1081 KLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSD 1140
Query: 733 RRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKA-- 790
+ + ++ E GG+ ++ M E + + E+ LQ+++ A
Sbjct: 1141 LSRELEEISERLEE------AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194
Query: 791 --------MQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKEL 842
++ EQ L+ KL + E + L+ T++++++I+ + L + L
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL 1254
Query: 843 EANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQ 902
E + K + + +++ F T+ + + G++ +++ I ++ KL
Sbjct: 1255 EDQ---ANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYT 1311
Query: 903 QDKLDKINKQLDECASAITKAQVAIKTA---------------------DRNLQKAQDSV 941
Q +++ + +QL+E A A+++A R L KA V
Sbjct: 1312 Q-QMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEV 1370
Query: 942 L--RTEKE---IKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQE 996
RT+ E I+ TE E+++ +L A E V+ NA SL + + +N +++
Sbjct: 1371 AQWRTKYETDAIQRTE-ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIED 1429
Query: 997 LKVIQENEH----ALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIE-DNP 1051
L V E + AL K + L + E S+++ KE +S + N
Sbjct: 1430 LMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNA 1489
Query: 1052 IEEISVLSPEDLEAIKNPD-SITNQIALLEARCHEMKPNLGAIAEYKKK---EELYLQRV 1107
EE S E LE K + ++ +I+ L + E N+ + + +K+ E+L LQ
Sbjct: 1490 YEE----SLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSA 1545
Query: 1108 AELDKITYERD 1118
E + + E +
Sbjct: 1546 LEEAEASLEHE 1556
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 102 bits (255), Expect = 2e-21
Identities = 185/940 (19%), Positives = 397/940 (42%), Gaps = 147/940 (15%)
Query: 283 EKLNRVKM-VEKEKDALEGEKNIAIEF-LTLEN------EIFRKKNHVCQYYIYELQKRI 334
E+ +++M +E+ K LEG+ +A E + +EN E +KK ++ + LQ +I
Sbjct: 1043 EQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKK----EFEMSGLQSKI 1098
Query: 335 AEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQL- 393
+ + ++ + KE+ + L E++A+ EK+ + +++ +EE E+ +
Sbjct: 1099 EDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1158
Query: 394 ----------------------DLEDVQVREKL-------KHATSKAKKLEK--QLQKDK 422
DLE+ ++ + KHA S A+ E+ LQ+ K
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1218
Query: 423 EKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESRE 482
+K+E+ KS + I++ + + K K EK + + D L E +++E
Sbjct: 1219 QKLEKEKS---EMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS--------EIKTKE 1267
Query: 483 KELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIR 542
+E + R+++ E L +T VSQL++ K+A E LK
Sbjct: 1268 EEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKR------ 1321
Query: 543 DIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSL--AMNRSRGKVL 600
Q E+E+K K L Q + L+ + +++ +EAK+ L AM+++ +V
Sbjct: 1322 -------QLEEEIKAKSA-LAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVA 1373
Query: 601 --------DAIIQ-EKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIA 651
DAI + E+ + RL D E++ A+++ C +L+ +
Sbjct: 1374 QWRTKYETDAIQRTEELEEAKKKLAQRLQDA----EEHVEAVNAKCASLEKTKQRLQNEV 1429
Query: 652 QECVNFLKRQNIGVATFIGLDK--------MAVWAKKMTEIQTPENTPRLFDLVKVKDEK 703
++ + ++R N A LDK +A W +K E + K+ +
Sbjct: 1430 EDLMIDVERTNAACAA---LDKKQRNFDKILAEWKQKCEETHAELEASQ-------KESR 1479
Query: 704 IRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRM 763
F +++ ++LDQ + + LQ +I + + + GG ++ +
Sbjct: 1480 SLSTELFKIKNAY-EESLDQLETLKRENKN------LQQEISDLTEQIAEGGKRIHE--- 1529
Query: 764 GSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEE-RVVKLRHSEREMRNTLEKFT 822
E++ K Q +++ + A++ E ++ EE ++++++ ++++ +++
Sbjct: 1530 ---------LEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKI 1580
Query: 823 ASIQRLIEQEEYLNVQVKE-LEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVE 881
A I+Q + ++++ E +++ + A + L++ + E + A ++
Sbjct: 1581 AEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1640
Query: 882 AEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSV 941
AE R + I LK Q LD + ++ + + +++ + ++
Sbjct: 1641 AEALRNYRNTQAI----LKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATL 1696
Query: 942 LRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQ 1001
+TE+ K E+E+ D + ++ L + ++ E + +IQ E +++QE + +
Sbjct: 1697 EQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAE 1756
Query: 1002 ENEHALQKDA--LSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIED---------- 1049
E DA ++ +LK EQ + H ++K ++ K H +++
Sbjct: 1757 EKAKKAITDAAMMAEELKKEQ---DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1813
Query: 1050 NPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMK-PNLGAIAEYKKKEELYLQRVA 1108
I+++ +LE + N A+ R HE K L E +K L LQ +
Sbjct: 1814 KQIQKLEA-RVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDL- 1871
Query: 1109 ELDKITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKE 1148
+DK+ + S+++ E+ +Q N ++ F I ++L+E
Sbjct: 1872 -VDKLQAKVKSYKRQAEEAEEQS-NVNLSKFRRIQHELEE 1909
Score = 98.2 bits (243), Expect = 4e-20
Identities = 167/855 (19%), Positives = 339/855 (39%), Gaps = 84/855 (9%)
Query: 249 GMLEYLEDIIGCG-RLNEPIKVLCRRVEILNEH-RGEKLNRVKMVEKEKDALEGEKNIAI 306
G+ +ED G +L + IK L R+E L E E+ +R K EK++ L E
Sbjct: 1093 GLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAK-AEKQRSDLSRE----- 1146
Query: 307 EFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKN 366
L +E + I +KR AE + + + E T + + L +
Sbjct: 1147 --LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1204
Query: 367 KDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAK-KLEKQLQKDKEKV 425
++ + L ++ + +E+ K + +++++D+ + SKAK LEK + ++++
Sbjct: 1205 AELGEQIDNLQRVKQKLEKEKSEM-KMEIDDLASNME---TVSKAKGNLEKMCRALEDQL 1260
Query: 426 EEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQG----------LQ 475
E K+ + +IN+ T + L+ E + ++L E + Q ++G L+
Sbjct: 1261 SEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELK 1320
Query: 476 KEKESREKELMGFSKSVNEARSKMDV----------AQSELDIYLSRHNTAVSQL-TKAK 524
++ E K + ++ +R D+ A++EL +S+ N+ V+Q TK +
Sbjct: 1321 RQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYE 1380
Query: 525 EALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVE 584
I +E L+E K + + +L E+ ++ + L + + ++ V DL VE
Sbjct: 1381 TDAIQRTEELEEAK---KKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVE 1437
Query: 585 EAKSSLAMNRSRGKVLDAIIQEKKS------GRIPGIYGRLGDLGAIDEKYDVAISSCCH 638
++ A + + D I+ E K + L K A
Sbjct: 1438 RTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLD 1497
Query: 639 ALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVK 698
L+ + ++ ++ QE + ++ G L+K+ KK E + E L +
Sbjct: 1498 QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI----KKQVEQEKSELQAALEEAEA 1553
Query: 699 VKDEKIRQAFYFALRDTLVADNLDQAT-----RVAYQKDRRWRVVTLQGQIIEQSGTMTG 753
+ + + L V +D+ + K R+V ++
Sbjct: 1554 SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRN 1613
Query: 754 GGSKVMKGRMGSSLVIEISEEEVNKM----------------ESQLQNDSKKAMQ--IQE 795
++ K G +EI N+M ++QL D Q ++E
Sbjct: 1614 DAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKE 1673
Query: 796 QKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKK 855
Q +E R L+ E+R TLE+ S R I ++E L+ + + T+ K
Sbjct: 1674 QLAMVERRANLLQAEIEELRATLEQTERS--RKIAEQELLDASERVQLLHTQNTSLINTK 1731
Query: 856 QKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDK---LDKINKQ 912
+KL E ++S + E + + ++A E + K+ T + +LK +QD L+++ K
Sbjct: 1732 KKL-ETDISQIQGEMEDIIQEARNAEEKAKKAI-TDAAMMAEELKKEQDTSAHLERMKKN 1789
Query: 913 LDECASAITKA-----QVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLED 967
L++ + Q+A+K + +QK + V E E++ +K + L+ E
Sbjct: 1790 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHER 1849
Query: 968 KAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAE 1027
K E+ T +++ +Q L ++K + ++ + K +I + E
Sbjct: 1850 KVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEE 1909
Query: 1028 HNSKIKYWHKEISKI 1042
+ +++K+
Sbjct: 1910 AEERADIAESQVNKL 1924
Score = 95.9 bits (237), Expect = 2e-19
Identities = 144/765 (18%), Positives = 320/765 (41%), Gaps = 94/765 (12%)
Query: 329 ELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKE 388
E +K +A M+ + EK E+ + K L +M ++ D + ++ + + +E
Sbjct: 848 ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEE 907
Query: 389 KFTQLDLEDVQVREKLKHATSKA--------------KKLEKQLQKDKEKVEEFKSIPAK 434
+ QL +Q+ K+K T +A +KLE + + K+ +++ + AK
Sbjct: 908 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 967
Query: 435 SNNIINETTTRNNALEKEKEKEEKKLK----------EVMDSLKQETQGLQKEKESREKE 484
+EKEK E K+K E + L +E + LQ+ + +
Sbjct: 968 --------------VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1013
Query: 485 LMGFSKSVN---EARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAI 541
L VN +A+ K++ +L+ L + L +AK L LK + +
Sbjct: 1014 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKL---EGDLKLAQEST 1070
Query: 542 RDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLD 601
DIE Q +++LK+KE E+ L + + ++L L +K++E ++R + L+
Sbjct: 1071 MDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKEL-------QARIEELE 1123
Query: 602 AIIQEKKSGRIPGIYGRLG---DLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFL 658
I+ +++ R R +L I E+ + A + ++ ++ +E
Sbjct: 1124 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE------MNKKREAEFQK 1177
Query: 659 KRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVA 718
R+++ AT A KK + E ++ +L +VK + ++ + +A
Sbjct: 1178 MRRDLEEATLQHEATAATLRKKHAD-SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1236
Query: 719 DNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNK 778
N++ ++ ++ R L+ Q+ E + + R+ + L + + +
Sbjct: 1237 SNMETVSKAKGNLEKMCR--ALEDQLSEIK------TKEEEQQRLINDLTAQRARLQTES 1288
Query: 779 MESQLQNDSKKAM--QIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLN 836
E Q D K + Q+ K +++ +L+ R++ ++ +A L +
Sbjct: 1289 GEYSRQLDEKDTLVSQLSRGKQAFTQQIEELK---RQLEEEIKAKSALAHALQSSRHDCD 1345
Query: 837 VQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA-EKAGKVEAEVKRLHNTI---- 891
+ ++ E A A ++ V+ ++T+Y+ A ++ ++E K+L +
Sbjct: 1346 LLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1405
Query: 892 --VEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIK 949
VE N K + + ++ ++++ + + A D+ + + +++ +
Sbjct: 1406 EHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCE 1465
Query: 950 DTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQ---KEHRNLLQELKVIQE---- 1002
+T E++ E +SL + E+ K NA EESL +++ +E++NL QE+ + E
Sbjct: 1466 ETHAELEASQKESRSL---STELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE 1522
Query: 1003 ---NEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISL 1044
H L+K ++ + ++ + E + +++ +I +I L
Sbjct: 1523 GGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQL 1567
Score = 93.6 bits (231), Expect = 1e-18
Identities = 143/756 (18%), Positives = 320/756 (42%), Gaps = 97/756 (12%)
Query: 282 GEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQK 341
GE+++ ++ V+++ + + E + I+ L E K + L+ +++E++T++
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKE 1267
Query: 342 EKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITK----FIEENKEKFTQLDLED 397
E+ ++ + L E ++ + + + ++++++ F ++ +E QL+ E+
Sbjct: 1268 EEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLE-EE 1326
Query: 398 VQVREKLKHATSKAKK----LEKQLQKDKEKVEEFKSIPAKSNNIINETTT--------R 445
++ + L HA ++ L +Q ++++E E + +K+N+ + + T R
Sbjct: 1327 IKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQR 1386
Query: 446 NNALEKEKEKEEKKLKEVMD----------SLKQETQGLQKEKE--------------SR 481
LE+ K+K ++L++ + SL++ Q LQ E E +
Sbjct: 1387 TEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAAL 1446
Query: 482 EKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAI 541
+K+ F K + E + K + +EL+ + ++L K K A + + L+ K
Sbjct: 1447 DKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKREN 1506
Query: 542 RDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLD 601
++++ ++ +++ E K + +L + + + +L +EEA++SL GK+L
Sbjct: 1507 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASL--EHEEGKILR 1564
Query: 602 AIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQ 661
+ +L + + D I+ +D + + I I + + L +
Sbjct: 1565 IQL----------------ELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAE 1608
Query: 662 NIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIR--QAFYFALRDTLVAD 719
I A+ KK E E +L ++ E +R + L+DT +
Sbjct: 1609 -------IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQL-- 1659
Query: 720 NLDQATRVAYQKDRRWRVV-----TLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEE 774
+LD A R + +V LQ +I E T+ + + R + + + E
Sbjct: 1660 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATL----EQTERSRKIAEQELLDASE 1715
Query: 775 EVNKMESQ---LQNDSKK-AMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIE 830
V + +Q L N KK I + + ++E+ + + R++E + + + + L +
Sbjct: 1716 RVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKK 1775
Query: 831 QEE---YLNVQVKELEANV--LATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVK 885
+++ +L K LE V L D+ +Q L+ + V E G+VE+E K
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK 1835
Query: 886 RLHNTIVEINNH--KLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQD---- 939
R + + H K+K + ++ K + + K Q +K+ R ++A++
Sbjct: 1836 RNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNV 1895
Query: 940 ---SVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEV 972
R + E+++ E+ D +++ L K+ EV
Sbjct: 1896 NLSKFRRIQHELEEAEERADIAESQVNKLRVKSREV 1931
Score = 87.8 bits (216), Expect = 6e-17
Identities = 163/871 (18%), Positives = 357/871 (40%), Gaps = 105/871 (12%)
Query: 199 ISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMM-KPKGQTEHDEGMLEYLEDI 257
++ KK+ +D + L+ D+D + + E E+ A K K TE G
Sbjct: 940 LTAKKRKLEDECSELKK---DIDDLELTLAKVEKEKHATENKVKNLTEEMAG-------- 988
Query: 258 IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFR 317
L+E I L + + L E + L+ ++ E + + L K + LE ++
Sbjct: 989 -----LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK------IKLEQQVDD 1037
Query: 318 KKNHVCQYYIYELQKRIA-EMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKL 376
+ + E +K+I ++E K K+ D K E + + N+ + ++ +K E ++
Sbjct: 1038 LEGSL------EQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEM 1091
Query: 377 NKITKFIEENK-------EKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFK 429
+ + IE+ + +K +L ++ E+++ + K EKQ ++EE
Sbjct: 1092 SGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1151
Query: 430 SIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFS 489
++ + N E E +K + L+E + L+K+ EL
Sbjct: 1152 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1211
Query: 490 KSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLP 549
++ + K++ +SE+ + + + + ++KAK L + R +E +L
Sbjct: 1212 DNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNL----------EKMCRALEDQLS 1261
Query: 550 QTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGK--------VLD 601
+ + + +E+++ + LT + ++ + ++++E K +L SRGK L
Sbjct: 1262 EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDE-KDTLVSQLSRGKQAFTQQIEELK 1320
Query: 602 AIIQEK---KSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFL 658
++E+ KS + D + E+Y+ + + + ++AQ
Sbjct: 1321 RQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQ------ 1374
Query: 659 KRQNIGVATFIGLDKMAVWAKKMTE-IQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLV 717
R +++ KK+ + +Q E + EK +Q + D ++
Sbjct: 1375 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMI 1434
Query: 718 ADNLDQATRVAYQKDRR--WRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEIS--- 772
A A K +R +++ Q E++ K + R S+ + +I
Sbjct: 1435 DVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK--ESRSLSTELFKIKNAY 1492
Query: 773 EEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQE 832
EE ++++E+ + + +I + Q+ E ++ E+ I++ +EQE
Sbjct: 1493 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK------------IKKQVEQE 1540
Query: 833 E-YLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYD-AVAEKAGKVEAEVKRLHNT 890
+ L ++E EA++ ++ K ++ ++ K+E D +AEK +++ ++KR H
Sbjct: 1541 KSELQAALEEAEASL---EHEEGKILRIQLELNQVKSEVDRKIAEKDEEID-QMKRNHIR 1596
Query: 891 IVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKD 950
IVE L A+ + + + + + ++ + A+R +A + T+ +KD
Sbjct: 1597 IVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKD 1656
Query: 951 TEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEI-----QKEHRNLLQELKVIQENE- 1004
T+ +DD + L+++ A V + N + + E+ Q E + E +++ +E
Sbjct: 1657 TQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASER 1716
Query: 1005 ----HALQKDALSIKLKLE----QIDGHIAE 1027
H ++ K KLE QI G + +
Sbjct: 1717 VQLLHTQNTSLINTKKKLETDISQIQGEMED 1747
Score = 67.0 bits (162), Expect = 1e-10
Identities = 73/366 (19%), Positives = 171/366 (46%), Gaps = 41/366 (11%)
Query: 772 SEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQ 831
+E+E+ M+ + + ++ + + ++ +LEE++V L + +++ ++ A L +
Sbjct: 849 TEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ---AEADSLADA 905
Query: 832 EEYLNVQVK---ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLH 888
EE + +K +LEA + + ++ + ++A K + + ++ +++ ++ L
Sbjct: 906 EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLE---DECSELKKDIDDLE 962
Query: 889 NTIVEINNHKLKAQQDKLDKINKQ---LDECASAITKAQVAIKTADR----NLQKAQDSV 941
T+ ++ K A ++K+ + ++ LDE + +TK + A++ A + +LQ +D V
Sbjct: 963 LTLAKVEKEK-HATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1021
Query: 942 LRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQ 1001
K E++VDDL L+ ++K + ++++ R L +LK+ Q
Sbjct: 1022 NTLTKAKIKLEQQVDDLEGSLE--QEKKIRM------------DLERAKRKLEGDLKLAQ 1067
Query: 1002 ENEHALQKDALSIKLKLEQIDGHIAEHNSKIK-------YWHKEISKISLHPIEDNPIEE 1054
E+ ++ D + KL++ + ++ SKI+ K+I ++ IE+ EE
Sbjct: 1068 ESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQAR-IEELE-EE 1125
Query: 1055 ISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRV-AELDKI 1113
I +A K ++ ++ + R E A E KK E Q++ +L++
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEA 1185
Query: 1114 TYERDS 1119
T + ++
Sbjct: 1186 TLQHEA 1191
Score = 64.7 bits (156), Expect = 5e-10
Identities = 144/772 (18%), Positives = 303/772 (39%), Gaps = 121/772 (15%)
Query: 410 KAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSL-- 467
K+ + EK++ KE+ E+ K AK+ E + L +EK + +++ DSL
Sbjct: 845 KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904
Query: 468 -----------KQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTA 516
K + + KE R ++ + + + K++ SEL +
Sbjct: 905 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 964
Query: 517 VSQLTKAKEALIAASETLKERKAAIRDIEGKL-----------PQTEQELKEKEKELQKL 565
++++ K K A + L E A + + KL QT +L+ +E ++ L
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1024
Query: 566 TQEETNFKSLVHDLFQKVE-EAKSSLAMNRSRGKV--------------------LDAII 604
T+ + + V DL +E E K + + R++ K+ LD +
Sbjct: 1025 TKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKL 1084
Query: 605 QEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIG 664
+KK + G+ ++ D A+ + I ++ + +I E + K +
Sbjct: 1085 -KKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEEL---EEEIEAERASRAKAEK-- 1138
Query: 665 VATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLD-Q 723
+ + ++++ EI +++ K R+A + +R L L +
Sbjct: 1139 --------QRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190
Query: 724 ATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISE--EEVNKMES 781
AT +K V L QI R+ L E SE E++ + S
Sbjct: 1191 ATAATLRKKHADSVAELGEQIDNLQ-------------RVKQKLEKEKSEMKMEIDDLAS 1237
Query: 782 QLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKE 841
++ SK +++ LE+++ +++ E E + + TA RL + + Q+
Sbjct: 1238 NMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLD- 1296
Query: 842 LEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKA 901
E + L + + KQ ++ + + + K+ A H+ ++ + +
Sbjct: 1297 -EKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHD--CDLLREQYEE 1353
Query: 902 QQDKLDKINKQLDECASAITKAQVAIKT-ADRNLQKAQDSVLRTEKEIKDTEKEVDDLTA 960
+Q+ ++ + + + S + + + +T A + ++ +++ + + ++D E+ V+ + A
Sbjct: 1354 EQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNA 1413
Query: 961 ELKSLEDKAAEV----------VKNTNAAEESLPEIQKEHRNLLQELKVIQENEH----A 1006
+ SLE + V+ TNAA +L + Q+ +L E K E H A
Sbjct: 1414 KCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA 1473
Query: 1007 LQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAI 1066
QK++ S+ +L KIK ++E ++++ L E+
Sbjct: 1474 SQKESRSLSTEL-----------FKIKNAYEE------------SLDQLETLKRENKNLQ 1510
Query: 1067 KNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERD 1118
+ +T QIA R HE++ I + ++E+ LQ E + + E +
Sbjct: 1511 QEISDLTEQIAEGGKRIHELE----KIKKQVEQEKSELQAALEEAEASLEHE 1558
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
Length = 1116
Score = 101 bits (252), Expect = 4e-21
Identities = 164/820 (20%), Positives = 342/820 (41%), Gaps = 102/820 (12%)
Query: 289 KMVEKEKDALEGEKNIAIEFLT--LENEIFRKKNHVCQYYIYELQKRIAEMETQK----- 341
K VE ++ L N F + L+ E +K+ + I++ Q R+ + E Q
Sbjct: 170 KDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTI 229
Query: 342 EKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQL-----DLE 396
+ + ++ + + + + + ++ + E + E++ + +L LE
Sbjct: 230 QALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLE 289
Query: 397 DVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRN---------- 446
++++R + + T A+ ++ ++K E ++ K + AK+ +E T R
Sbjct: 290 EMELRIETQKQTLNAR--DESIKKLLEMLQS-KGLSAKATEEDHERTRRLAEAEMHVHHL 346
Query: 447 NALEKEKEKEEKKLKEVM--------DSLKQETQGLQKEKESREKELMGFSKSVNEARSK 498
+L ++KEKE L+E M DS K T+ LQ E ++ ++ + + + +
Sbjct: 347 ESLLEQKEKENSMLREEMHRRFENAPDSAK--TKALQTVIEMKDSKISSMERGLRDLEEE 404
Query: 499 MDVAQS--------------ELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDI 544
+ + +S ++++Y S +++ + KE L + +E K +
Sbjct: 405 IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGL 464
Query: 545 EGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAII 604
+ ++ Q +QEL K+ EL L + + D Q +E K SL R +L +
Sbjct: 465 QAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEV 524
Query: 605 Q------EKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFL 658
E+K + ++ D+ +EK A H L D +D+ + VN L
Sbjct: 525 DALRLRLEEKETMLNKKTKQIQDMA--EEKGTQAGE--IHDLK----DMLDVKERKVNVL 576
Query: 659 KR--QNIGVATFIGLDKMAVWAKKMTEIQ--TPENTPRLFDLVKVKDEKIRQAFYFALRD 714
++ +N+ +M+ +++ +Q T L L + EK R L++
Sbjct: 577 QKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIE--RLKE 634
Query: 715 TLVADNLDQATRVAYQK----DRRWRVVTLQGQIIEQ----------SGTMTGGGSKVMK 760
D ++ + K D + +V LQG + E+ + ++ G K
Sbjct: 635 QRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 694
Query: 761 GRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEK 820
+ +E +EE KMESQL+ + A++ + ++ +R+ L ++ K
Sbjct: 695 RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASP-EMSDRIQHLEREITRYKDESSK 753
Query: 821 FTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKV 880
A + RL+E + + + + + + K Q + V+ K + +K+ ++
Sbjct: 754 AQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQ---NKKVANLKHKEQVEKKKSAQM 810
Query: 881 EAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDS 940
E +R + + N + QD L K + +++E A+ + V I TA+R + AQ+
Sbjct: 811 LEEARRREDNL----NDSSQQLQDSLRKKDDRIEELEEAL-RESVQI-TAEREMVLAQEE 864
Query: 941 VLRT--EKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELK 998
RT EK++++ ++ + EL+S++ K + ++ E L ++ E R L+E
Sbjct: 865 SARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEE-- 922
Query: 999 VIQENEHAL-----QKDALSIKLKLEQIDGHIAEHNSKIK 1033
V++ + AL +KDA L+L E + +K
Sbjct: 923 VLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALK 962
Score = 75.5 bits (184), Expect = 3e-13
Identities = 72/406 (17%), Positives = 176/406 (43%), Gaps = 24/406 (5%)
Query: 227 ILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLN 286
+L + +QI M + T+ G + L+D++ + VL +++E L E +K
Sbjct: 537 MLNKKTKQIQDMAEEKGTQ--AGEIHDLKDMLDVKE--RKVNVLQKKIENLQEQLRDKEK 592
Query: 287 RVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHE 346
++ +++ +L+ + LT E +K + + + E + + + +
Sbjct: 593 QMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKK 652
Query: 347 DTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKH 406
D K++ EK ++L ++ K + D ++ + + + + L++ Q +E+
Sbjct: 653 DLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLK 712
Query: 407 ATSKAKK-------------LEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEK 453
S+ KK + ++Q + ++ +K +K+ ++ +E EK
Sbjct: 713 MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK 772
Query: 454 EKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMD---VAQSELDIYL 510
++KK+ E+ +K + + + K + E ++ + EAR + D + +L L
Sbjct: 773 NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSL 832
Query: 511 SRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEET 570
+ + + +L +EAL + + ER+ + E E++++E ++K+ QE
Sbjct: 833 RKKDDRIEEL---EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELE 889
Query: 571 NFKSLVHDLFQKVEEAKSSLA-MNRSRGKVLDAIIQEKKSGRIPGI 615
+ K+ + Q + E ++ L + R K L+ +++ K+ + I
Sbjct: 890 SMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAI 935
Score = 75.1 bits (183), Expect = 4e-13
Identities = 147/672 (21%), Positives = 266/672 (39%), Gaps = 131/672 (19%)
Query: 233 EQIAMMKPKG--QTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKM 290
E+I M+K G TE E ++ +E K + +VE L E K + +
Sbjct: 403 EEIQMLKSNGALSTEEREEEMKQMEVY------RSHSKFMKNKVEQLKEELSSKEAQWEE 456
Query: 291 VEKEKDALEGEKNIAIEFLTLENEIFRKKNHVC--QYYIYELQKRIAEMETQKEKIHEDT 348
++K+ L+ E ++ E+ RK + Q + L + ++ + E + E
Sbjct: 457 LKKKAAGLQAEIG------QVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESL 510
Query: 349 KEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEEN-KEKFTQL----DLEDV-QVRE 402
+++ IL E+ A +++ E LNK TK I++ +EK TQ DL+D+ V+E
Sbjct: 511 TAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKE 570
Query: 403 -KLKHATSKAKKLEKQLQKDKEK-----VEEFKSIPAKSNNIINETTTRNNALEKEKEKE 456
K+ K + L++QL +DKEK E KS+ A + N TT AL EKE+
Sbjct: 571 RKVNVLQKKIENLQEQL-RDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL-AEKERT 628
Query: 457 EKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTA 516
++LKE D +++ +++E+ + K + + + K+ + Q +L
Sbjct: 629 IERLKEQRD----------RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS------EKE 672
Query: 517 VSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLV 576
S L + A AS LK+ + +L E L++K++E K+ +
Sbjct: 673 ASLLDLKEHASSLASSGLKK--------DSRLKTLEIALEQKKEECLKMESQ-------- 716
Query: 577 HDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSC 636
+K EA L+A + S RI + + K +
Sbjct: 717 ---LKKAHEA------------ALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRL 761
Query: 637 CHALDYIVVDSIDIAQECVNF---LKRQNIGVATFIGLDKMAVWAKKMTEI--------- 684
L + + D ++ +K QN VA K V KK ++
Sbjct: 762 LEILKEVENEKNDKDKKIAELERQVKDQNKKVANL--KHKEQVEKKKSAQMLEEARRRED 819
Query: 685 QTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQI 744
+++ +L D ++ KD++I + L++A R + Q +V Q +
Sbjct: 820 NLNDSSQQLQDSLRKKDDRI--------------EELEEALRESVQITAEREMVLAQEE- 864
Query: 745 IEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERV 804
R + +E + K++ +L++ K Q+ + E +
Sbjct: 865 ---------------SARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHL 909
Query: 805 VKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVS 864
LR E R LE+ L ++E L + E +AN+ K+K EE V+
Sbjct: 910 TNLR---AERRKHLEEV------LEMKQEALLAAISEKDANIALLELSSSKKKTQEE-VA 959
Query: 865 AFKTEYDAVAEK 876
A K E D + ++
Sbjct: 960 ALKREKDRLVQQ 971
Score = 66.6 bits (161), Expect = 1e-10
Identities = 71/299 (23%), Positives = 142/299 (47%), Gaps = 31/299 (10%)
Query: 311 LENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVK 370
LE EI R K+ E K AE++ ++ E KE+ + N ++ + VK
Sbjct: 740 LEREITRYKD--------ESSKAQAEVD----RLLEILKEVENEKNDKDKKIAELERQVK 787
Query: 371 DTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKS 430
D KK+ + + K+K Q+ LE+ + RE + +++L+ L+K +++EE +
Sbjct: 788 DQNKKVANLKHKEQVEKKKSAQM-LEEARRRED--NLNDSSQQLQDSLRKKDDRIEELEE 844
Query: 431 IPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSK 490
+S I E E + EK+++E++ ++++ +++E ES + +L +
Sbjct: 845 ALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEK----VKQELESMKAKLSSTQQ 900
Query: 491 SVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQ 550
S+ E + + ++E R L +EAL+AA K+ A+ ++ +
Sbjct: 901 SLAEKETHLTNLRAE------RRKHLEEVLEMKQEALLAAISE-KDANIALLELSSSKKK 953
Query: 551 TEQEL----KEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQ 605
T++E+ +EK++ +Q+L Q+ N L+ D ++ + KSS + + D IIQ
Sbjct: 954 TQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED-DHFKSSHSNQTNHKPSPDQIIQ 1011
Score = 55.8 bits (133), Expect = 3e-07
Identities = 70/366 (19%), Positives = 159/366 (43%), Gaps = 39/366 (10%)
Query: 772 SEEEVNKMESQLQNDSKKAMQIQEQ------------KVQLEERVVKLRHS-----EREM 814
+E V+ +ES L+ K+ ++E+ K + + V++++ S ER +
Sbjct: 339 AEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGL 398
Query: 815 RNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA 874
R+ E+ E ++K++E + K K + L+E +S+ + +++ +
Sbjct: 399 RDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELK 458
Query: 875 EKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNL 934
+KA ++AE+ ++ + + +L A Q KL+ + Q + I + ++ ++
Sbjct: 459 KKAAGLQAEIGQVKQELSR-KDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRA 517
Query: 935 QKAQDSV----LRTE----------KEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAE 980
Q V LR E K+I+D +E E+ L+D + N +
Sbjct: 518 AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQ 577
Query: 981 ESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEIS 1040
+ + +Q++ R+ +++ ++E +LQ D + L ++ +AE I+ ++
Sbjct: 578 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 637
Query: 1041 KISLHPIEDNPIEEISVLSPEDLEAIKNPDS-ITNQIALLEARCHEMKPNLGAIAEYKKK 1099
+ E EEI +DL+ +K S + ++ EA ++K + ++A K
Sbjct: 638 R-----DEREKQEEIDNYK-KDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK 691
Query: 1100 EELYLQ 1105
++ L+
Sbjct: 692 KDSRLK 697
Score = 48.9 bits (115), Expect = 3e-05
Identities = 76/468 (16%), Positives = 196/468 (41%), Gaps = 69/468 (14%)
Query: 722 DQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMK-----------GRMGSSLVIE 770
D+A+++ K++ +RVV + Q ++ + ++ + R G V E
Sbjct: 203 DEASKITIWKEQ-YRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAE 261
Query: 771 ISEEEVNKMESQLQNDSKKAM----QIQEQKVQLEERVVKLRHSEREMRNTLEKFTAS-- 824
++EE ++ ++ + +K+ ++E ++++E + L + ++ LE +
Sbjct: 262 LTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGL 321
Query: 825 ------------------------IQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLE 860
++ L+EQ+E N ++E APD K K L+
Sbjct: 322 SAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQ 381
Query: 861 ENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAI 920
+ ++ ++ +E E++ L + ++ + + + +++ + +
Sbjct: 382 TVIEMKDSKISSMERGLRDLEEEIQMLKSN-GALSTEEREEEMKQMEVYRSHSKFMKNKV 440
Query: 921 TKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAE 980
+ + + + + ++ + + EI ++E+ EL +L+ K + TN
Sbjct: 441 EQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETL---TNQFS 497
Query: 981 ESLPEIQKEHRNLLQELKVIQENEHA-LQKDALSIKLKLEQIDGHIAEHNSKIKYWHKE- 1038
+S K+H +L+E +E A LQ + +++L+LE+ + + + +I+ +E
Sbjct: 498 DS-----KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEK 552
Query: 1039 -ISKISLHPIED---------NPIE-EISVLSPEDLEAIKNPDSITNQIALLEARCHEMK 1087
+H ++D N ++ +I L + + K S+ ++ L+A
Sbjct: 553 GTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTD 612
Query: 1088 PNLGAIAEYKKKEELYLQRVAE-LDKITYER----DSFRQAYEDLRKQ 1130
L + E ++E ++R+ E D+ E+ D++++ +DL+++
Sbjct: 613 TALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK 660
Score = 33.9 bits (76), Expect = 1.0
Identities = 37/175 (21%), Positives = 70/175 (40%), Gaps = 19/175 (10%)
Query: 263 LNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHV 322
L E +++ R +L + + N K VE E +A+E + E E + K
Sbjct: 846 LRESVQITAEREMVLAQEESARTNAEKQVE--------ELLMAMEKVKQELESMKAK--- 894
Query: 323 CQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKF 382
+ Q+ +AE ET + + ++ E+ + E KD L +++
Sbjct: 895 ----LSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSS 950
Query: 383 IEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNN 437
++ +E+ L E ++ ++LK T K L D + + FKS + N
Sbjct: 951 KKKTQEEVAALKREKDRLVQQLKQQTQNRMK----LMADNYEDDHFKSSHSNQTN 1001
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 101 bits (252), Expect = 4e-21
Identities = 175/911 (19%), Positives = 399/911 (43%), Gaps = 89/911 (9%)
Query: 283 EKLNRVKM-VEKEKDALEGEKNIAIE-FLTLENEIFR--KKNHVCQYYIYELQKRIAEME 338
E+ +++M +E+ K LEG+ +A E + +ENE + +K ++ I LQ +I + +
Sbjct: 1045 EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQ 1104
Query: 339 TQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLD---L 395
++ + KE+ + L E++A+ EK+ + +++ +EE E+ +
Sbjct: 1105 ALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1164
Query: 396 EDVQVREKLKHATSKAKK-LEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKE 454
+++ +K + K ++ LE+ + + + A S + E ++++ E
Sbjct: 1165 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1224
Query: 455 KEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQ---SELDIYLS 511
KE+ ++K +D L + + K K + EK ++E +SK + Q ++L
Sbjct: 1225 KEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRG 1284
Query: 512 RHNTAVSQLTKA---KEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQE 568
R T + ++ KEAL+ S+ + ++A + IE Q E+E+K K L Q
Sbjct: 1285 RLQTESGEFSRQLDEKEALV--SQLSRGKQAFTQQIEELKRQLEEEIKAKNA-LAHALQS 1341
Query: 569 ETNFKSLVHDLFQKVEEAKSSL--AMNRSRGKVL--------DAIIQEKKSGRIPGIYGR 618
+ L+ + +++ +E+K+ L A++++ +V DAI +++ + +
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAI---QRTEELEEAKKK 1398
Query: 619 LGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDK----- 673
L E++ A+++ C +L+ + ++ + ++R N A LDK
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAA---LDKKQRNF 1455
Query: 674 ---MAVWAKKMTEIQTP-ENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAY 729
+A W +K E E + + + + KI+ A+ ++LDQ +
Sbjct: 1456 DKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAY---------EESLDQLETLKR 1506
Query: 730 QKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKK 789
+ LQ +I + + + GG ++ + E++ K Q + + +
Sbjct: 1507 ENKN------LQQEISDLTEQIAEGGKRIHE------------LEKIKKQVEQEKCELQA 1548
Query: 790 AMQIQEQKVQLEE-RVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKE-LEANVL 847
A++ E ++ EE ++++++ ++++ +++ A I+Q + ++++ E +++ +
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608
Query: 848 ATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLD 907
A + L++ + E + A ++ AE R + I LK Q LD
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGI----LKDTQIHLD 1664
Query: 908 KINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLED 967
+ ++ + + +++ + ++ +TE+ K E+E+ D + ++ L
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1724
Query: 968 KAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDA--LSIKLKLEQ-IDGH 1024
+ ++ E + ++Q E ++LQE + +E DA ++ +LK EQ H
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784
Query: 1025 IAEHNSKIKYWHKEISKISLHPIEDNPI----EEISVLSP--EDLEAIKNPDSITNQIAL 1078
+ ++ K++ ++ L E + ++I L +LE + N A+
Sbjct: 1785 LERMKKNMEQTVKDL-QLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843
Query: 1079 LEARCHEMK-PNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMA 1137
R HE + L E +K L LQ + +DK+ + S+++ E+ +Q N +A
Sbjct: 1844 KGLRKHERRVKELTYQTEEDRKNILRLQDL--VDKLQAKVKSYKRQAEEAEEQS-NTNLA 1900
Query: 1138 GFYIITNKLKE 1148
F + ++L+E
Sbjct: 1901 KFRKLQHELEE 1911
Score = 100 bits (250), Expect = 7e-21
Identities = 155/779 (19%), Positives = 325/779 (41%), Gaps = 122/779 (15%)
Query: 329 ELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKE 388
E +K +A M+ + +KI ++ + K L +M K+ D + ++ + + + +E
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 389 KFTQLDLEDVQVREKLKHATSKA--------------KKLEKQLQKDKEKVEEFKSIPAK 434
+ QL +Q+ K+K T +A +KLE + + K+ +++ + AK
Sbjct: 910 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969
Query: 435 SNNIINETTTRNNALEKEKEKEEKKLK----------EVMDSLKQETQGLQKEKESREKE 484
+EKEK E K+K E + L +E + LQ+ + +
Sbjct: 970 --------------VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015
Query: 485 LMGFSKSVN---EARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAI 541
L VN +A+ K++ +L+ L + L +AK L LK + +I
Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKL---EGDLKLAQESI 1072
Query: 542 RDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLD 601
DIE + Q +++LK+KE E+ L + + ++L L +K++E ++R + L+
Sbjct: 1073 MDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKEL-------QARIEELE 1125
Query: 602 AIIQEKKSGRIPGIYGRLG---DLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFL 658
I+ +++ R R +L I E+ + A + ++ ++ +E
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE------MNKKREAEFQK 1179
Query: 659 KRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVA 718
R+++ AT A KK + E ++ +L +VK + ++ + +A
Sbjct: 1180 MRRDLEEATLQHEATAATLRKKHAD-SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238
Query: 719 DNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNK 778
N++ ++ ++ R TL+ Q+ E + + R+ + L + +
Sbjct: 1239 SNVETVSKAKGNLEKMCR--TLEDQLSELK------SKEEEQQRLINDLTAQRGRLQTES 1290
Query: 779 MESQLQNDSKKAM-------------QIQEQKVQLEERVV---KLRHSEREMRNTLEKFT 822
E Q D K+A+ QI+E K QLEE + L H+ + R+ +
Sbjct: 1291 GEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLR 1350
Query: 823 ASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA-EKAGKVE 881
+ EQE +Q +AN V+ ++T+Y+ A ++ ++E
Sbjct: 1351 EQYEE--EQESKAELQRALSKANT---------------EVAQWRTKYETDAIQRTEELE 1393
Query: 882 AEVKRLHNTI------VEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQ 935
K+L + VE N K + + ++ ++++ + + A D+ +
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453
Query: 936 KAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQ---KEHRN 992
+ +++ ++T E++ E +SL E+ K NA EESL +++ +E++N
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSL---GTELFKIKNAYEESLDQLETLKRENKN 1510
Query: 993 LLQELKVIQE-------NEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISL 1044
L QE+ + E H L+K ++ + ++ + E + +++ +I +I L
Sbjct: 1511 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQL 1569
Score = 99.0 bits (245), Expect = 3e-20
Identities = 160/841 (19%), Positives = 332/841 (39%), Gaps = 83/841 (9%)
Query: 262 RLNEPIKVLCRRVEILNEH-RGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKN 320
+L + IK L R+E L E E+ +R K EK++ L E L +E +
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAK-AEKQRSDLSRE-------LEEISERLEEAG 1160
Query: 321 HVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKIT 380
I +KR AE + + + E T + + L + ++ + L ++
Sbjct: 1161 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1220
Query: 381 KFIEENKEKFTQLDLEDVQVREKLKHATSKAK-KLEKQLQKDKEKVEEFKSIPAKSNNII 439
+ +E+ K + +++++D+ + SKAK LEK + ++++ E KS + +I
Sbjct: 1221 QKLEKEKSEM-KMEIDDLASNVE---TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 440 NETTTRNNALEKE----------KEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFS 489
N+ T + L+ E KE +L + Q+ + L+++ E K +
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA 1336
Query: 490 KSVNEARSKMDV----------AQSELDIYLSRHNTAVSQL-TKAKEALIAASETLKERK 538
++ +R D+ +++EL LS+ NT V+Q TK + I +E L+E K
Sbjct: 1337 HALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAK 1396
Query: 539 AAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGK 598
+ + +L E+ ++ + L + + ++ V DL VE ++ A + +
Sbjct: 1397 ---KKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453
Query: 599 VLDAIIQEKKS------GRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQ 652
D I+ E K + LG K A L+ + ++ ++ Q
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513
Query: 653 ECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFAL 712
E + ++ G L+K+ KK E + E L + + + + L
Sbjct: 1514 EISDLTEQIAEGGKRIHELEKI----KKQVEQEKCELQAALEEAEASLEHEEGKILRIQL 1569
Query: 713 RDTLVADNLDQAT-----RVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSL 767
V +D+ + K R+V ++ ++ K G
Sbjct: 1570 ELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1629
Query: 768 VIEISEEEVNKMESQ------------------LQNDSKKAMQIQEQKVQLEERVVKLRH 809
+EI N+M ++ L + + ++EQ +E R L+
Sbjct: 1630 EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689
Query: 810 SEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTE 869
E+R TLE+ S R I ++E L+ + + T+ K+KL E ++S + E
Sbjct: 1690 EIEELRATLEQTERS--RKIAEQELLDASERVQLLHTQNTSLINTKKKL-ETDISQMQGE 1746
Query: 870 YDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDK---LDKINKQLDECASAIT----- 921
+ + ++A E + K+ T + +LK +QD L+++ K +++ +
Sbjct: 1747 MEDILQEARNAEEKAKKAI-TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDE 1805
Query: 922 KAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEE 981
Q+A+K + +QK + V E E++ +K + L+ E + E+ T +
Sbjct: 1806 AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRK 1865
Query: 982 SLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISK 1041
++ +Q L ++K + ++ + + K ++ + E + +++K
Sbjct: 1866 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925
Query: 1042 I 1042
+
Sbjct: 1926 L 1926
Score = 90.5 bits (223), Expect = 9e-18
Identities = 165/861 (19%), Positives = 347/861 (40%), Gaps = 105/861 (12%)
Query: 199 ISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMM-KPKGQTEHDEGMLEYLEDI 257
++ KK+ +D + L+ D+D + + E E+ A K K TE G
Sbjct: 942 LTAKKRKLEDECSELKK---DIDDLELTLAKVEKEKHATENKVKNLTEEMAG-------- 990
Query: 258 IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFR 317
L+E I L + + L E + L+ ++ E + + L K + LE ++
Sbjct: 991 -----LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK------IKLEQQVDD 1039
Query: 318 KKNHVCQYYIYELQKRIA-EMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKL 376
+ + E +K++ ++E K K+ D K E + NE + ++ +K E ++
Sbjct: 1040 LEGSL------EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI 1093
Query: 377 NKITKFIEENK-------EKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFK 429
+ + IE+ + +K +L ++ E+++ + K EKQ ++EE
Sbjct: 1094 SNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1153
Query: 430 SIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFS 489
++ + N E E +K + L+E + L+K+ EL
Sbjct: 1154 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1213
Query: 490 KSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLP 549
++ + K++ +SE+ + + + V ++KAK L TL+++ +
Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS---------- 1263
Query: 550 QTEQELKEKEKELQKLTQEETNFKSLVH---DLFQKVEEAKSSLAMNRSRGK-------- 598
ELK KE+E Q+L + T + + F + + K +L SRGK
Sbjct: 1264 ----ELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIE 1319
Query: 599 VLDAIIQEK---KSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECV 655
L ++E+ K+ + D + E+Y+ S + + ++AQ
Sbjct: 1320 ELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ--- 1376
Query: 656 NFLKRQNIGVATFIGLDKMAVWAKKMTE-IQTPENTPRLFDLVKVKDEKIRQAFYFALRD 714
R +++ KK+ + +Q E + EK +Q + D
Sbjct: 1377 ---WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVED 1433
Query: 715 TLVADNLDQATRVAYQKDRR--WRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSL--VIE 770
++ A A K +R +++ Q E++ K + +G+ L +
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS-LGTELFKIKN 1492
Query: 771 ISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIE 830
EE ++++E+ + + +I + Q+ E ++ E+ I++ +E
Sbjct: 1493 AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK------------IKKQVE 1540
Query: 831 QEE-YLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYD-AVAEKAGKVEAEVKRLH 888
QE+ L ++E EA++ ++ K ++ ++ K+E D +AEK +++ ++KR H
Sbjct: 1541 QEKCELQAALEEAEASL---EHEEGKILRIQLELNQVKSEVDRKIAEKDEEID-QLKRNH 1596
Query: 889 NTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEI 948
IVE L A+ + + + + + ++ + A+R +A + T+ +
Sbjct: 1597 IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL 1656
Query: 949 KDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEI-----QKEHRNLLQELKVIQEN 1003
KDT+ +DD + L+++ A V + N + + E+ Q E + E +++ +
Sbjct: 1657 KDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDAS 1716
Query: 1004 E-----HALQKDALSIKLKLE 1019
E H ++ K KLE
Sbjct: 1717 ERVQLLHTQNTSLINTKKKLE 1737
Score = 90.1 bits (222), Expect = 1e-17
Identities = 141/756 (18%), Positives = 321/756 (42%), Gaps = 97/756 (12%)
Query: 282 GEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQK 341
GE+++ ++ V+++ + + E + I+ L E K + L+ +++E+++++
Sbjct: 1210 GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE 1269
Query: 342 EKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITK----FIEENKEKFTQLDLED 397
E+ ++ + L E ++ + + E ++++++ F ++ +E QL+ E+
Sbjct: 1270 EEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLE-EE 1328
Query: 398 VQVREKLKHATSKAKK----LEKQLQKDKEKVEEFKSIPAKSNNIINETTTR--NNALEK 451
++ + L HA ++ L +Q ++++E E + +K+N + + T+ +A+++
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR 1388
Query: 452 EKEKEEKKLK------------EVMD----SLKQETQGLQKEKE--------------SR 481
+E EE K K E ++ SL++ Q LQ E E +
Sbjct: 1389 TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL 1448
Query: 482 EKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAI 541
+K+ F K + E + K + +EL+ + ++L K K A + + L+ K
Sbjct: 1449 DKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKREN 1508
Query: 542 RDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLD 601
++++ ++ +++ E K + +L + + + +L +EEA++SL GK+L
Sbjct: 1509 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASL--EHEEGKILR 1566
Query: 602 AIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQ 661
+ +L + + D I+ +D + + I I + + L +
Sbjct: 1567 IQL----------------ELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAE 1610
Query: 662 NIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIR--QAFYFALRDTLVAD 719
I A+ KK E E +L ++ E +R + L+DT +
Sbjct: 1611 -------IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQI-- 1661
Query: 720 NLDQATRVAYQKDRRWRVV-----TLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEE 774
+LD A R + +V LQ +I E T+ + + R + + + E
Sbjct: 1662 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATL----EQTERSRKIAEQELLDASE 1717
Query: 775 EVNKMESQ---LQNDSKK-AMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIE 830
V + +Q L N KK I + + ++E+ + + R++E + + + + L +
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 831 QEE---YLNVQVKELEANV--LATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVK 885
+++ +L K +E V L D+ +Q L+ + V E G+VE+E K
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK 1837
Query: 886 RLHNTIVEINNH--KLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQD---- 939
R + + H ++K + ++ K + + K Q +K+ R ++A++
Sbjct: 1838 RNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNT 1897
Query: 940 ---SVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEV 972
+ + E+++ E+ D +++ L K+ EV
Sbjct: 1898 NLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
Score = 66.6 bits (161), Expect = 1e-10
Identities = 147/753 (19%), Positives = 292/753 (38%), Gaps = 83/753 (11%)
Query: 410 KAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSL-- 467
K+ + EK++ KE+ ++ K AKS E + L KEK + +++ + L
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLAD 906
Query: 468 -----------KQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTA 516
K + + KE R ++ + + + K++ SEL +
Sbjct: 907 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 966
Query: 517 VSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKE-LQKLTQEETNFKSL 575
++++ K K A + L E A + + KL + ++ L+E ++ L L EE +L
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026
Query: 576 VH---DLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVA 632
L Q+V++ + SL + L+ + K G + + D+ ++ D
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLER-AKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 633 ISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPR 692
+ +I+ Q +G+ + ++ +++ E E R
Sbjct: 1086 LKK----------KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135
Query: 693 LFDLVKVKD-----EKIRQAFYFALRDTLVADNLDQATRVAYQKDRR-WRVVTLQGQIIE 746
+ D E+I + A T +++ +QK RR TLQ +
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195
Query: 747 QSGTMTGGGSKVMKG-------RMGSSLVIEISE--EEVNKMESQLQNDSKKAMQIQEQK 797
+ S G R+ L E SE E++ + S ++ SK +++
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255
Query: 798 VQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQK 857
LE+++ +L+ E E + + TA RL + + Q+ E EA L + + KQ
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA--LVSQLSRGKQA 1313
Query: 858 LLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECA 917
++ + E ++E E+K N + H L++ + D + +Q +E
Sbjct: 1314 FTQQ-----------IEELKRQLEEEIK-AKNALA----HALQSSRHDCDLLREQYEEEQ 1357
Query: 918 SAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN 977
+ + Q A+ A N + AQ I+ TE E+++ +L A E V+ N
Sbjct: 1358 ESKAELQRALSKA--NTEVAQWRTKYETDAIQRTE-ELEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 978 AAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHK 1037
A SL + ++ +N +++L + E +A ++ K D +AE K + H
Sbjct: 1415 AKCASLEKTKQRLQNEVEDLMLDVERTNAA---CAALDKKQRNFDKILAEWKQKCEETHA 1471
Query: 1038 EISK------------ISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHE 1085
E+ + + ++++ L E+ + +T QIA R HE
Sbjct: 1472 ELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 1531
Query: 1086 MKPNLGAIAEYKKKEELYLQRVAELDKITYERD 1118
++ I + ++E+ LQ E + + E +
Sbjct: 1532 LE----KIKKQVEQEKCELQAALEEAEASLEHE 1560
Score = 60.8 bits (146), Expect = 8e-09
Identities = 121/652 (18%), Positives = 259/652 (39%), Gaps = 86/652 (13%)
Query: 216 HGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIG-CGRLNEPIKVLCRRV 274
H DL ++ Q ++ K TE + +Y D I L E K L +R+
Sbjct: 1344 HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1403
Query: 275 EILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRI 334
+ EH + +EK K L+ E +E L L+ E + N C
Sbjct: 1404 QAAEEHVEAVNAKCASLEKTKQRLQNE----VEDLMLDVE---RTNAAC----------- 1445
Query: 335 AEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLD 394
A ++ ++ + E +K E++A K+ + +L KI EE+ ++ L
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLK 1505
Query: 395 LEDVQVREKLKHATSKAKKLEK---QLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEK 451
E+ +++++ T + + K +L+K K++VE+ K E E
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC----------ELQAALEEAEA 1555
Query: 452 EKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLS 511
E EE K+ + L Q + ++ +++E+ + N R ++ QS LD +
Sbjct: 1556 SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR--NHIRI-VESMQSTLDAEIR 1612
Query: 512 RHNTAV-------SQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQK 564
N A+ L + + L A+ E R+ +G L T+ L + + +
Sbjct: 1613 SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQED 1672
Query: 565 LTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGA 624
L ++ + + L ++EE +++L K+ + + + S R+ ++ + L
Sbjct: 1673 LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA-SERVQLLHTQNTSLIN 1731
Query: 625 IDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEI 684
+K + IS ++ DI QE N ++ + A E+
Sbjct: 1732 TKKKLETDISQMQGEME-------DILQEARNAEEKAKKAITDA---------AMMAEEL 1775
Query: 685 QTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQI 744
+ ++T + +K E+ ++D + LD+A ++A + ++ ++ L+ ++
Sbjct: 1776 KKEQDTSAHLERMKKNMEQ-------TVKDLQL--RLDEAEQLALKGGKK-QIQKLEARV 1825
Query: 745 IEQSGTMTGG---GSKVMKG-----RMGSSLVIEISEEE---------VNKMESQLQNDS 787
E G + ++ +KG R L + E+ V+K+++++++
Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885
Query: 788 KKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQV 839
++A + +EQ + KL+H E + + + +L + ++ +V
Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKV 1937
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 101 bits (252), Expect = 4e-21
Identities = 175/911 (19%), Positives = 399/911 (43%), Gaps = 89/911 (9%)
Query: 283 EKLNRVKM-VEKEKDALEGEKNIAIE-FLTLENEIFR--KKNHVCQYYIYELQKRIAEME 338
E+ +++M +E+ K LEG+ +A E + +ENE + +K ++ I LQ +I + +
Sbjct: 1045 EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQ 1104
Query: 339 TQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLD---L 395
++ + KE+ + L E++A+ EK+ + +++ +EE E+ +
Sbjct: 1105 ALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1164
Query: 396 EDVQVREKLKHATSKAKK-LEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKE 454
+++ +K + K ++ LE+ + + + A S + E ++++ E
Sbjct: 1165 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1224
Query: 455 KEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQ---SELDIYLS 511
KE+ ++K +D L + + K K + EK ++E +SK + Q ++L
Sbjct: 1225 KEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRG 1284
Query: 512 RHNTAVSQLTKA---KEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQE 568
R T + ++ KEAL+ S+ + ++A + IE Q E+E+K K L Q
Sbjct: 1285 RLQTESGEFSRQLDEKEALV--SQLSRGKQAFTQQIEELKRQLEEEIKAKNA-LAHALQS 1341
Query: 569 ETNFKSLVHDLFQKVEEAKSSL--AMNRSRGKVL--------DAIIQEKKSGRIPGIYGR 618
+ L+ + +++ +E+K+ L A++++ +V DAI +++ + +
Sbjct: 1342 SRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAI---QRTEELEEAKKK 1398
Query: 619 LGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDK----- 673
L E++ A+++ C +L+ + ++ + ++R N A LDK
Sbjct: 1399 LAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAA---LDKKQRNF 1455
Query: 674 ---MAVWAKKMTEIQTP-ENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAY 729
+A W +K E E + + + + KI+ A+ ++LDQ +
Sbjct: 1456 DKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAY---------EESLDQLETLKR 1506
Query: 730 QKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKK 789
+ LQ +I + + + GG ++ + E++ K Q + + +
Sbjct: 1507 ENKN------LQQEISDLTEQIAEGGKRIHE------------LEKIKKQVEQEKCELQA 1548
Query: 790 AMQIQEQKVQLEE-RVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKE-LEANVL 847
A++ E ++ EE ++++++ ++++ +++ A I+Q + ++++ E +++ +
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608
Query: 848 ATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLD 907
A + L++ + E + A ++ AE R + I LK Q LD
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGI----LKDTQIHLD 1664
Query: 908 KINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLED 967
+ ++ + + +++ + ++ +TE+ K E+E+ D + ++ L
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1724
Query: 968 KAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDA--LSIKLKLEQ-IDGH 1024
+ ++ E + ++Q E ++LQE + +E DA ++ +LK EQ H
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784
Query: 1025 IAEHNSKIKYWHKEISKISLHPIEDNPI----EEISVLSP--EDLEAIKNPDSITNQIAL 1078
+ ++ K++ ++ L E + ++I L +LE + N A+
Sbjct: 1785 LERMKKNMEQTVKDL-QLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAV 1843
Query: 1079 LEARCHEMK-PNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMA 1137
R HE + L E +K L LQ + +DK+ + S+++ E+ +Q N +A
Sbjct: 1844 KGLRKHERRVKELTYQTEEDRKNILRLQDL--VDKLQAKVKSYKRQAEEAEEQS-NTNLA 1900
Query: 1138 GFYIITNKLKE 1148
F + ++L+E
Sbjct: 1901 KFRKLQHELEE 1911
Score = 100 bits (250), Expect = 7e-21
Identities = 155/779 (19%), Positives = 325/779 (41%), Gaps = 122/779 (15%)
Query: 329 ELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKE 388
E +K +A M+ + +KI ++ + K L +M K+ D + ++ + + + +E
Sbjct: 850 ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909
Query: 389 KFTQLDLEDVQVREKLKHATSKA--------------KKLEKQLQKDKEKVEEFKSIPAK 434
+ QL +Q+ K+K T +A +KLE + + K+ +++ + AK
Sbjct: 910 RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 969
Query: 435 SNNIINETTTRNNALEKEKEKEEKKLK----------EVMDSLKQETQGLQKEKESREKE 484
+EKEK E K+K E + L +E + LQ+ + +
Sbjct: 970 --------------VEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015
Query: 485 LMGFSKSVN---EARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAI 541
L VN +A+ K++ +L+ L + L +AK L LK + +I
Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKL---EGDLKLAQESI 1072
Query: 542 RDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLD 601
DIE + Q +++LK+KE E+ L + + ++L L +K++E ++R + L+
Sbjct: 1073 MDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKEL-------QARIEELE 1125
Query: 602 AIIQEKKSGRIPGIYGRLG---DLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFL 658
I+ +++ R R +L I E+ + A + ++ ++ +E
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE------MNKKREAEFQK 1179
Query: 659 KRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVA 718
R+++ AT A KK + E ++ +L +VK + ++ + +A
Sbjct: 1180 MRRDLEEATLQHEATAATLRKKHAD-SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238
Query: 719 DNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNK 778
N++ ++ ++ R TL+ Q+ E + + R+ + L + +
Sbjct: 1239 SNVETVSKAKGNLEKMCR--TLEDQLSELK------SKEEEQQRLINDLTAQRGRLQTES 1290
Query: 779 MESQLQNDSKKAM-------------QIQEQKVQLEERVV---KLRHSEREMRNTLEKFT 822
E Q D K+A+ QI+E K QLEE + L H+ + R+ +
Sbjct: 1291 GEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLR 1350
Query: 823 ASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVA-EKAGKVE 881
+ EQE +Q +AN V+ ++T+Y+ A ++ ++E
Sbjct: 1351 EQYEE--EQESKAELQRALSKANT---------------EVAQWRTKYETDAIQRTEELE 1393
Query: 882 AEVKRLHNTI------VEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQ 935
K+L + VE N K + + ++ ++++ + + A D+ +
Sbjct: 1394 EAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453
Query: 936 KAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQ---KEHRN 992
+ +++ ++T E++ E +SL E+ K NA EESL +++ +E++N
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSL---GTELFKIKNAYEESLDQLETLKRENKN 1510
Query: 993 LLQELKVIQE-------NEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISL 1044
L QE+ + E H L+K ++ + ++ + E + +++ +I +I L
Sbjct: 1511 LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQL 1569
Score = 99.0 bits (245), Expect = 3e-20
Identities = 160/841 (19%), Positives = 332/841 (39%), Gaps = 83/841 (9%)
Query: 262 RLNEPIKVLCRRVEILNEH-RGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKN 320
+L + IK L R+E L E E+ +R K EK++ L E L +E +
Sbjct: 1109 QLQKKIKELQARIEELEEEIEAERASRAK-AEKQRSDLSRE-------LEEISERLEEAG 1160
Query: 321 HVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKIT 380
I +KR AE + + + E T + + L + ++ + L ++
Sbjct: 1161 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1220
Query: 381 KFIEENKEKFTQLDLEDVQVREKLKHATSKAK-KLEKQLQKDKEKVEEFKSIPAKSNNII 439
+ +E+ K + +++++D+ + SKAK LEK + ++++ E KS + +I
Sbjct: 1221 QKLEKEKSEM-KMEIDDLASNVE---TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 440 NETTTRNNALEKE----------KEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFS 489
N+ T + L+ E KE +L + Q+ + L+++ E K +
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA 1336
Query: 490 KSVNEARSKMDV----------AQSELDIYLSRHNTAVSQL-TKAKEALIAASETLKERK 538
++ +R D+ +++EL LS+ NT V+Q TK + I +E L+E K
Sbjct: 1337 HALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAK 1396
Query: 539 AAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGK 598
+ + +L E+ ++ + L + + ++ V DL VE ++ A + +
Sbjct: 1397 ---KKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453
Query: 599 VLDAIIQEKKS------GRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQ 652
D I+ E K + LG K A L+ + ++ ++ Q
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQ 1513
Query: 653 ECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFAL 712
E + ++ G L+K+ KK E + E L + + + + L
Sbjct: 1514 EISDLTEQIAEGGKRIHELEKI----KKQVEQEKCELQAALEEAEASLEHEEGKILRIQL 1569
Query: 713 RDTLVADNLDQAT-----RVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSL 767
V +D+ + K R+V ++ ++ K G
Sbjct: 1570 ELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1629
Query: 768 VIEISEEEVNKMESQ------------------LQNDSKKAMQIQEQKVQLEERVVKLRH 809
+EI N+M ++ L + + ++EQ +E R L+
Sbjct: 1630 EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689
Query: 810 SEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTE 869
E+R TLE+ S R I ++E L+ + + T+ K+KL E ++S + E
Sbjct: 1690 EIEELRATLEQTERS--RKIAEQELLDASERVQLLHTQNTSLINTKKKL-ETDISQMQGE 1746
Query: 870 YDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDK---LDKINKQLDECASAIT----- 921
+ + ++A E + K+ T + +LK +QD L+++ K +++ +
Sbjct: 1747 MEDILQEARNAEEKAKKAI-TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDE 1805
Query: 922 KAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEE 981
Q+A+K + +QK + V E E++ +K + L+ E + E+ T +
Sbjct: 1806 AEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRK 1865
Query: 982 SLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISK 1041
++ +Q L ++K + ++ + + K ++ + E + +++K
Sbjct: 1866 NILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925
Query: 1042 I 1042
+
Sbjct: 1926 L 1926
Score = 90.5 bits (223), Expect = 9e-18
Identities = 165/861 (19%), Positives = 347/861 (40%), Gaps = 105/861 (12%)
Query: 199 ISGKKKTFKDVGNLLRSHGIDLDHNRFLILQGEVEQIAMM-KPKGQTEHDEGMLEYLEDI 257
++ KK+ +D + L+ D+D + + E E+ A K K TE G
Sbjct: 942 LTAKKRKLEDECSELKK---DIDDLELTLAKVEKEKHATENKVKNLTEEMAG-------- 990
Query: 258 IGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFR 317
L+E I L + + L E + L+ ++ E + + L K + LE ++
Sbjct: 991 -----LDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAK------IKLEQQVDD 1039
Query: 318 KKNHVCQYYIYELQKRIA-EMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKL 376
+ + E +K++ ++E K K+ D K E + NE + ++ +K E ++
Sbjct: 1040 LEGSL------EQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEI 1093
Query: 377 NKITKFIEENK-------EKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFK 429
+ + IE+ + +K +L ++ E+++ + K EKQ ++EE
Sbjct: 1094 SNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEIS 1153
Query: 430 SIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFS 489
++ + N E E +K + L+E + L+K+ EL
Sbjct: 1154 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1213
Query: 490 KSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLP 549
++ + K++ +SE+ + + + V ++KAK L TL+++ +
Sbjct: 1214 DNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLS---------- 1263
Query: 550 QTEQELKEKEKELQKLTQEETNFKSLVH---DLFQKVEEAKSSLAMNRSRGK-------- 598
ELK KE+E Q+L + T + + F + + K +L SRGK
Sbjct: 1264 ----ELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIE 1319
Query: 599 VLDAIIQEK---KSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECV 655
L ++E+ K+ + D + E+Y+ S + + ++AQ
Sbjct: 1320 ELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQ--- 1376
Query: 656 NFLKRQNIGVATFIGLDKMAVWAKKMTE-IQTPENTPRLFDLVKVKDEKIRQAFYFALRD 714
R +++ KK+ + +Q E + EK +Q + D
Sbjct: 1377 ---WRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVED 1433
Query: 715 TLVADNLDQATRVAYQKDRR--WRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSL--VIE 770
++ A A K +R +++ Q E++ K + +G+ L +
Sbjct: 1434 LMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARS-LGTELFKIKN 1492
Query: 771 ISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIE 830
EE ++++E+ + + +I + Q+ E ++ E+ I++ +E
Sbjct: 1493 AYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK------------IKKQVE 1540
Query: 831 QEE-YLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYD-AVAEKAGKVEAEVKRLH 888
QE+ L ++E EA++ ++ K ++ ++ K+E D +AEK +++ ++KR H
Sbjct: 1541 QEKCELQAALEEAEASL---EHEEGKILRIQLELNQVKSEVDRKIAEKDEEID-QLKRNH 1596
Query: 889 NTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEI 948
IVE L A+ + + + + + ++ + A+R +A + T+ +
Sbjct: 1597 IRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGIL 1656
Query: 949 KDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEI-----QKEHRNLLQELKVIQEN 1003
KDT+ +DD + L+++ A V + N + + E+ Q E + E +++ +
Sbjct: 1657 KDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDAS 1716
Query: 1004 E-----HALQKDALSIKLKLE 1019
E H ++ K KLE
Sbjct: 1717 ERVQLLHTQNTSLINTKKKLE 1737
Score = 90.1 bits (222), Expect = 1e-17
Identities = 141/756 (18%), Positives = 321/756 (42%), Gaps = 97/756 (12%)
Query: 282 GEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQK 341
GE+++ ++ V+++ + + E + I+ L E K + L+ +++E+++++
Sbjct: 1210 GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKE 1269
Query: 342 EKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITK----FIEENKEKFTQLDLED 397
E+ ++ + L E ++ + + E ++++++ F ++ +E QL+ E+
Sbjct: 1270 EEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLE-EE 1328
Query: 398 VQVREKLKHATSKAKK----LEKQLQKDKEKVEEFKSIPAKSNNIINETTTR--NNALEK 451
++ + L HA ++ L +Q ++++E E + +K+N + + T+ +A+++
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQR 1388
Query: 452 EKEKEEKKLK------------EVMD----SLKQETQGLQKEKE--------------SR 481
+E EE K K E ++ SL++ Q LQ E E +
Sbjct: 1389 TEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL 1448
Query: 482 EKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAI 541
+K+ F K + E + K + +EL+ + ++L K K A + + L+ K
Sbjct: 1449 DKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKREN 1508
Query: 542 RDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLD 601
++++ ++ +++ E K + +L + + + +L +EEA++SL GK+L
Sbjct: 1509 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASL--EHEEGKILR 1566
Query: 602 AIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQ 661
+ +L + + D I+ +D + + I I + + L +
Sbjct: 1567 IQL----------------ELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAE 1610
Query: 662 NIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIR--QAFYFALRDTLVAD 719
I A+ KK E E +L ++ E +R + L+DT +
Sbjct: 1611 -------IRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQI-- 1661
Query: 720 NLDQATRVAYQKDRRWRVV-----TLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEE 774
+LD A R + +V LQ +I E T+ + + R + + + E
Sbjct: 1662 HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATL----EQTERSRKIAEQELLDASE 1717
Query: 775 EVNKMESQ---LQNDSKK-AMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIE 830
V + +Q L N KK I + + ++E+ + + R++E + + + + L +
Sbjct: 1718 RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKK 1777
Query: 831 QEE---YLNVQVKELEANV--LATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVK 885
+++ +L K +E V L D+ +Q L+ + V E G+VE+E K
Sbjct: 1778 EQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQK 1837
Query: 886 RLHNTIVEINNH--KLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQD---- 939
R + + H ++K + ++ K + + K Q +K+ R ++A++
Sbjct: 1838 RNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNT 1897
Query: 940 ---SVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEV 972
+ + E+++ E+ D +++ L K+ EV
Sbjct: 1898 NLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
Score = 66.6 bits (161), Expect = 1e-10
Identities = 147/753 (19%), Positives = 292/753 (38%), Gaps = 83/753 (11%)
Query: 410 KAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSL-- 467
K+ + EK++ KE+ ++ K AKS E + L KEK + +++ + L
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLAD 906
Query: 468 -----------KQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTA 516
K + + KE R ++ + + + K++ SEL +
Sbjct: 907 AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 966
Query: 517 VSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKE-LQKLTQEETNFKSL 575
++++ K K A + L E A + + KL + ++ L+E ++ L L EE +L
Sbjct: 967 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1026
Query: 576 VH---DLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVA 632
L Q+V++ + SL + L+ + K G + + D+ ++ D
Sbjct: 1027 TKAKIKLEQQVDDLEGSLEQEKKLRMDLER-AKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 633 ISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPR 692
+ +I+ Q +G+ + ++ +++ E E R
Sbjct: 1086 LKK----------KEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135
Query: 693 LFDLVKVKD-----EKIRQAFYFALRDTLVADNLDQATRVAYQKDRR-WRVVTLQGQIIE 746
+ D E+I + A T +++ +QK RR TLQ +
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195
Query: 747 QSGTMTGGGSKVMKG-------RMGSSLVIEISE--EEVNKMESQLQNDSKKAMQIQEQK 797
+ S G R+ L E SE E++ + S ++ SK +++
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255
Query: 798 VQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQK 857
LE+++ +L+ E E + + TA RL + + Q+ E EA L + + KQ
Sbjct: 1256 RTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA--LVSQLSRGKQA 1313
Query: 858 LLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECA 917
++ + E ++E E+K N + H L++ + D + +Q +E
Sbjct: 1314 FTQQ-----------IEELKRQLEEEIK-AKNALA----HALQSSRHDCDLLREQYEEEQ 1357
Query: 918 SAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN 977
+ + Q A+ A N + AQ I+ TE E+++ +L A E V+ N
Sbjct: 1358 ESKAELQRALSKA--NTEVAQWRTKYETDAIQRTE-ELEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 978 AAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHK 1037
A SL + ++ +N +++L + E +A ++ K D +AE K + H
Sbjct: 1415 AKCASLEKTKQRLQNEVEDLMLDVERTNAA---CAALDKKQRNFDKILAEWKQKCEETHA 1471
Query: 1038 EISK------------ISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHE 1085
E+ + + ++++ L E+ + +T QIA R HE
Sbjct: 1472 ELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHE 1531
Query: 1086 MKPNLGAIAEYKKKEELYLQRVAELDKITYERD 1118
++ I + ++E+ LQ E + + E +
Sbjct: 1532 LE----KIKKQVEQEKCELQAALEEAEASLEHE 1560
Score = 60.8 bits (146), Expect = 8e-09
Identities = 121/652 (18%), Positives = 259/652 (39%), Gaps = 86/652 (13%)
Query: 216 HGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIG-CGRLNEPIKVLCRRV 274
H DL ++ Q ++ K TE + +Y D I L E K L +R+
Sbjct: 1344 HDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1403
Query: 275 EILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRI 334
+ EH + +EK K L+ E +E L L+ E + N C
Sbjct: 1404 QAAEEHVEAVNAKCASLEKTKQRLQNE----VEDLMLDVE---RTNAAC----------- 1445
Query: 335 AEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLD 394
A ++ ++ + E +K E++A K+ + +L KI EE+ ++ L
Sbjct: 1446 AALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLK 1505
Query: 395 LEDVQVREKLKHATSKAKKLEK---QLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEK 451
E+ +++++ T + + K +L+K K++VE+ K E E
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC----------ELQAALEEAEA 1555
Query: 452 EKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLS 511
E EE K+ + L Q + ++ +++E+ + N R ++ QS LD +
Sbjct: 1556 SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR--NHIRI-VESMQSTLDAEIR 1612
Query: 512 RHNTAV-------SQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQK 564
N A+ L + + L A+ E R+ +G L T+ L + + +
Sbjct: 1613 SRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQED 1672
Query: 565 LTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGA 624
L ++ + + L ++EE +++L K+ + + + S R+ ++ + L
Sbjct: 1673 LKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA-SERVQLLHTQNTSLIN 1731
Query: 625 IDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEI 684
+K + IS ++ DI QE N ++ + A E+
Sbjct: 1732 TKKKLETDISQMQGEME-------DILQEARNAEEKAKKAITDA---------AMMAEEL 1775
Query: 685 QTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQI 744
+ ++T + +K E+ ++D + LD+A ++A + ++ ++ L+ ++
Sbjct: 1776 KKEQDTSAHLERMKKNMEQ-------TVKDLQL--RLDEAEQLALKGGKK-QIQKLEARV 1825
Query: 745 IEQSGTMTGG---GSKVMKG-----RMGSSLVIEISEEE---------VNKMESQLQNDS 787
E G + ++ +KG R L + E+ V+K+++++++
Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885
Query: 788 KKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQV 839
++A + +EQ + KL+H E + + + +L + ++ +V
Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKV 1937
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 101 bits (251), Expect = 5e-21
Identities = 180/897 (20%), Positives = 373/897 (41%), Gaps = 94/897 (10%)
Query: 283 EKLNRVKMVEKEKD--ALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQ 340
EK ++ M+++ D AL EK A E E R KN ++E K+ +++T+
Sbjct: 246 EKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTE 305
Query: 341 KEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKIT----KFIEENKEKFTQLDLE 396
K ++ +++E++ LS +++ ++ + LN++T K +E EK QL+ E
Sbjct: 306 KSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKE 365
Query: 397 DVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKE 456
+ K K + L+ +L + +E + + + P + + + L+ E K+
Sbjct: 366 LSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEV-----LGDVLQLETLKQ 420
Query: 457 E-KKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNT 515
E L L+ + L+ E+ +E +L+ E + ++ ++L +S +
Sbjct: 421 EAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQ 480
Query: 516 AVSQLTKAKEA--------LIAASETLKERKAAIRDIEGKLPQTEQELKEKEKEL-QKLT 566
A +L +A +A + + + L A I+ + +L +Q+ KEK+ +L Q L
Sbjct: 481 AKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQ 540
Query: 567 QEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAID 626
Q+E + L H +VE+ SSL + K + + + + + A
Sbjct: 541 QQEQASQGLRH----QVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASL 596
Query: 627 EKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFI--GLDKMAVWAKKMTEI 684
+ D A+ AL+ ++I Q+ + T + + A ++K+ E+
Sbjct: 597 RERDAALKQ-LEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEEL 655
Query: 685 QTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQI 744
Q T R + + E Q L+ + RVA +KD+ + Q Q
Sbjct: 656 QACVETAR-----QEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQ----LQEQLQA 706
Query: 745 IEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAM-QIQEQKVQLEER 803
+++S +T G + K R +L EE + S+L+ +++ + Q + ++ +LEE
Sbjct: 707 LKESLKVTKGSLEEEKRRAADAL------EEQQRCISELKAETRSLVEQHKRERKELEE- 759
Query: 804 VVKLRHSEREMRNTLEKFTASIQRLIE-QEEYLNVQVKELEANVLATAPDKKKQKLLEEN 862
ER R LE A +Q+L E + V +EL + A + + + L +
Sbjct: 760 -------ERAGRKGLE---ARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKE 809
Query: 863 VSAFKTEYD------------------AVAEKAGKVEAEVKRLHNTIVEINNH---KLKA 901
V+A++ Y+ + E+ K E++ + I +H ++
Sbjct: 810 VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISR 869
Query: 902 QQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAE 961
QQ++L +++ L + + +V + +L Q+ + T KE+ E V
Sbjct: 870 QQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAG-- 927
Query: 962 LKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQI 1021
+ E + E+VK A + PE +E + ++ Q A++++A + +LE++
Sbjct: 928 -EQQETASRELVKEPARAGDRQPEWLEEQQG--RQFCSTQAALQAMEREAEQMGNELERL 984
Query: 1022 DGHIAEHNSKIK----YWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQ-- 1075
+ E + + +E+++++ + + +LE ++ +++ Q
Sbjct: 985 RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELE-MRLQNALNEQRV 1043
Query: 1076 --IALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQ 1130
L EA H + G E K L ++ EL+++ R + +Q E L K+
Sbjct: 1044 EFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEEL---RQTVKQLKEQLAKK 1097
Score = 76.6 bits (187), Expect = 1e-13
Identities = 152/852 (17%), Positives = 343/852 (40%), Gaps = 137/852 (16%)
Query: 227 ILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLN 286
ILQG++ Q+ + Q + E L D++ ++ L + L + +
Sbjct: 382 ILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVL-------QLETLKQEAATLAANNTQLQA 434
Query: 287 RVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHE 346
RV+M+E E+ E + L E F ++ I +LQ I+ + KE++ +
Sbjct: 435 RVEMLETERGQQEAK-------LLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQ 487
Query: 347 DTK----EINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVRE 402
++ + + L++E+ N ++ +++L + + +E + + Q + Q +
Sbjct: 488 ASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQ 547
Query: 403 KLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKE 462
L+H ++E+ K+K ++ K + K E T +++A + EE++
Sbjct: 548 GLRH------QVEQLSSSLKQKEQQLKEVAEKQ-----EATRQDHAQQLATAAEEREA-- 594
Query: 463 VMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTK 522
SL++ L K+ E+ EK E +K+++ Q +L + ++A + +T+
Sbjct: 595 ---SLRERDAAL-KQLEALEK----------EKAAKLEILQQQLQVANEARDSAQTSVTQ 640
Query: 523 AKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQK 582
A+ S ++E +A + + + + ++ E E +L+ Q+ T + + Q+
Sbjct: 641 AQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVA----QE 696
Query: 583 VEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDY 642
++ + L + KV ++E+K
Sbjct: 697 KDQLQEQLQALKESLKVTKGSLEEEKRR-------------------------------- 724
Query: 643 IVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDE 702
D+++ Q C++ LK + + ++ + ++ +L + + + E
Sbjct: 725 -AADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETE 783
Query: 703 KIRQ--AFYFALRDTLVADNLDQATRVAYQKDR---------------RWRVVTLQGQII 745
+R+ A A + T ++ VA ++R + +++TL+ +
Sbjct: 784 VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECE 843
Query: 746 EQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVV 805
+ + KV S L I + E+ ++ + L ++ Q+QE++V+ ++
Sbjct: 844 KARQELQEAKEKVAGIESHSELQISRQQNELAELHANL---ARALQQVQEKEVRAQKLAD 900
Query: 806 KLRHSEREMRNTLEKFTASIQRLI-----EQEEYLNVQVKELEANVLATAPDKKKQKLLE 860
L + +M T K A ++ L+ +QE VKE A A D++ + L E
Sbjct: 901 DLSTLQEKMAAT-SKEVARLETLVRKAGEQQETASRELVKE-----PARAGDRQPEWLEE 954
Query: 861 ENVSAF---KTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECA 917
+ F + A+ +A ++ E++RL ++E QQ++ + +++
Sbjct: 955 QQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQ----QQEERGQQEREVARLT 1010
Query: 918 SAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTN 977
+AQ AD L+KA R E E++ + +++ E +L++ A +
Sbjct: 1011 QERGRAQ-----ADLALEKA----ARAELEMR-LQNALNEQRVEFATLQEALAHALTEKE 1060
Query: 978 AAEESLPEIQ-------KEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNS 1030
++ L +++ KE L Q +K ++E +K+ S + G
Sbjct: 1061 GKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGP 1120
Query: 1031 KIKYWHKEISKI 1042
K++ E+SK+
Sbjct: 1121 KLEALRAEVSKL 1132
Score = 73.2 bits (178), Expect = 2e-12
Identities = 129/734 (17%), Positives = 290/734 (39%), Gaps = 96/734 (13%)
Query: 331 QKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKF 390
Q + ME + E++ NE + + M+++ + ++ ++ ++ + +E
Sbjct: 964 QAALQAMEREAEQMG------NELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQ 1017
Query: 391 TQLDLEDVQVREKLKHATSKAKKLEKQLQKD-KEKVEEFKSIPAKSNNIINETTTRNNAL 449
L LE E LE +LQ E+ EF ++ + + E ++ L
Sbjct: 1018 ADLALEKAARAE-----------LEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQEL 1066
Query: 450 EKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIY 509
K + E ++KE ++ L+Q + L+++ +EKE S + +EA + + +L+
Sbjct: 1067 AKLRGLEAAQIKE-LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEAL 1125
Query: 510 LSRHNTAVSQLTKAKEALIAASETLK-------ERKAAIRDIEGKLPQTEQELKEKEKEL 562
+ + Q K +E + +L+ ER +A+ ++G+L + QEL + L
Sbjct: 1126 RAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSAL 1185
Query: 563 QKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDL 622
+E F++ V D + +E K+ +A R + +++I
Sbjct: 1186 ASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLI------------------ 1227
Query: 623 GAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMT 682
+++E+ + L+ V++ ++E LKR + +A K+ ++
Sbjct: 1228 SSLEEEVSI--------LNRQVLEKEGESKE----LKR--LVMAESEKSQKLEE-RLRLL 1272
Query: 683 EIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQG 742
+ +T N+ R + E+++ A + + ++NL Q +T Q
Sbjct: 1273 QAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQE-------------LTSQA 1319
Query: 743 QIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEE 802
+ E+ G + + + +++ + S+L Q+Q ++ E+
Sbjct: 1320 ERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK 1379
Query: 803 RVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKKKQKLLEEN 862
R + ++ L QR + + L +V E E + Q+L E
Sbjct: 1380 RHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQE---------RTAQQLRAEK 1430
Query: 863 VSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITK 922
S E ++ +KA + AE R + L+ + D+ + K + E A+
Sbjct: 1431 AS--YAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQARE--KYVQELAAVRAD 1486
Query: 923 AQVAIKTADRNLQ-----------KAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAE 971
A+ + R Q K + + ++ +E + ++E LTA+++ LE E
Sbjct: 1487 AETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQRE 1546
Query: 972 VVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSK 1031
K + L + + + Q+LK +Q Q++A ++ +L ++ +++
Sbjct: 1547 QTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606
Query: 1032 IKYWHKEISKISLH 1045
+++ ++ K H
Sbjct: 1607 AEHYKLQMEKAKTH 1620
Score = 68.6 bits (166), Expect = 4e-11
Identities = 130/723 (17%), Positives = 295/723 (40%), Gaps = 62/723 (8%)
Query: 279 EHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIY--ELQKRIAE 336
E RG++ V + +E+ + + +A+E R +N + + + LQ+ +A
Sbjct: 997 EERGQQEREVARLTQERGRAQAD--LALEKAARAELEMRLQNALNEQRVEFATLQEALAH 1054
Query: 337 METQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLE 396
T+KE ++ ++ E++ + VK +++L K K ++
Sbjct: 1055 ALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGR 1114
Query: 397 DVQVREKLKHATSKAKKLEKQLQKDKEKVEEF-KSIPAKSNNIINETTTRNNALEKEKEK 455
KL+ ++ KLE+Q QK +E+ + +S+ A+ + R++ALE + +
Sbjct: 1115 TEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERAS----RAERDSALETLQGQ 1170
Query: 456 EEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNT 515
E+K +E+ S + Q+E + ++ SK+ +E ++++ + E + R N+
Sbjct: 1171 LEEKAQELGHS-QSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE----RKNS 1225
Query: 516 AVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSL 575
+S L +E + + + E++ ++++ +L E E +K +E +L Q ET S
Sbjct: 1226 LISSL---EEEVSILNRQVLEKEGESKELK-RLVMAESEKSQKLEERLRLLQAETASNSA 1281
Query: 576 -VHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKY---DV 631
+ + E SL + +V ++++ + + +L A EK+ +
Sbjct: 1282 RAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQ 1341
Query: 632 AISSCC--HALDYIVVDSIDIAQECVNFLKRQNIGVATF----IGLDKMAVWAKKMTEIQ 685
A+S+ H +V + A+ L+ + + K A + ++
Sbjct: 1342 ALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLR 1401
Query: 686 TPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQII 745
L L + E+ R A A+ L + G +
Sbjct: 1402 AQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKA-------------HGLLA 1448
Query: 746 EQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQ-----L 800
E++ G G + GR + ++ + E+ + + ++ D++ + +++ Q L
Sbjct: 1449 EEN---RGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTAREL 1505
Query: 801 EERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNV----QVKELEANVLATAPDKKKQ 856
E K ++ ++ ++F Q+L Q E L V Q K++E A +
Sbjct: 1506 EVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQAS 1565
Query: 857 KLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVE---------INNHKLKAQQDKLD 907
K+ ++ + A + + ++A +++A++ L + + + K K D
Sbjct: 1566 KVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKK 1625
Query: 908 KINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLED 967
+ N++L E ++ + Q K ++ + + + K+ E+ LTA+++SLE
Sbjct: 1626 QQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEA 1685
Query: 968 KAA 970
+ A
Sbjct: 1686 QVA 1688
Score = 61.2 bits (147), Expect = 6e-09
Identities = 131/676 (19%), Positives = 277/676 (40%), Gaps = 94/676 (13%)
Query: 228 LQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLN------EPIKVLCRRVEILNEHR 281
L+ V+Q+ K + EH G E GR E ++ ++E + +
Sbjct: 1083 LRQTVKQLKEQLAKKEKEHASGSGAQSE---AAGRTEPTGPKLEALRAEVSKLEQQCQKQ 1139
Query: 282 GEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHV--CQYYIYELQKRIAEMET 339
E+ + ++ + + A E++ A+E TL+ ++ K + Q + Q+ +A T
Sbjct: 1140 QEQADSLERSLEAERASRAERDSALE--TLQGQLEEKAQELGHSQSALASAQRELAAFRT 1197
Query: 340 QKEKIHEDTKEINE-KSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDV 398
K+ + +K +E K+ + +A+ K N + +EE ++ + +
Sbjct: 1198 ---KVQDHSKAEDEWKAQVARGRQEAERK---------NSLISSLEE------EVSILNR 1239
Query: 399 QVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKE---K 455
QV EK + + + + +K ++ E + + A++ + R++AL +E + +
Sbjct: 1240 QVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLRE 1299
Query: 456 EEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNT 515
E +K + ++L+QE + E +EL K+ E + + A S L + +
Sbjct: 1300 EAEKQRVASENLRQELTSQAERAEELGQEL----KAWQEKFFQKEQALSTLQLEHTSTQA 1355
Query: 516 AVSQLTKAK------EALIAASET-----LKERKAAIRDIEGKLPQTEQELKEKEKELQK 564
VS+L AK +A AA+E L++ K A + +L + ++EL E QK
Sbjct: 1356 LVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQK 1415
Query: 565 LTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGA 624
+ ++E Q++ K+S A S K ++ E+ G G +LG
Sbjct: 1416 VAEQERTA--------QQLRAEKASYAEQLSMLKKAHGLLAEENRG-----LGERANLGR 1462
Query: 625 --IDEKYDVAISSCCHALDYIVVDS----IDIAQECVNFLKRQNIGVATFIGLDKMAVWA 678
++ + D A L + D+ ++ +E + + + A + G +
Sbjct: 1463 QFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEE 1522
Query: 679 KKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVV 738
++ + + + T ++ L + E+ +Q + + +AD+ DQA++V QK + V
Sbjct: 1523 RQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKK---LADS-DQASKVQQQK---LKAV 1575
Query: 739 TLQGQIIEQSGTMTGGGSKVMKGRMGSS--------LVIEISEEEVNKMESQ---LQNDS 787
QG +Q ++ ++ L +E ++ + + Q LQ
Sbjct: 1576 QAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL 1635
Query: 788 KKAMQIQEQKVQLEERVVKLRH-------SEREMRNTLEKFTASIQRLIEQEEYLNVQVK 840
+ Q+Q++ +L +L H +E T TA ++ L Q + + Q++
Sbjct: 1636 RSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLR 1695
Query: 841 ELEANVLATAPDKKKQ 856
+L +AT K ++
Sbjct: 1696 DLGKFQVATDALKSRE 1711
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 101 bits (251), Expect = 5e-21
Identities = 187/851 (21%), Positives = 350/851 (41%), Gaps = 152/851 (17%)
Query: 327 IYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEEN 386
I +L++RIA +E +K+K E ++ + + N L +++ K+ ++K +
Sbjct: 1842 IDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQ------------- 1888
Query: 387 KEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEE--FKSIPAKSNNIINETTT 444
E+ T+++L + Q++E+L S+ KL++ +++K+ +EE + + +I N
Sbjct: 1889 -EEVTKMNLLNQQIQEEL----SRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQD 1943
Query: 445 RNNALEKEK--EKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVA 502
+A K + E E K LK+ + L++E Q L KEK E E+ E K+ A
Sbjct: 1944 VTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIR------KEYLEKIQGA 1997
Query: 503 Q---------SELDIYLSRHNTAVSQLTK----AKEALIAASETLKERKAAIRDIEGKLP 549
Q EL L V QL K +E + A T+K + + + L
Sbjct: 1998 QKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLE 2057
Query: 550 QTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKS 609
T++ L + + +K E +FK L+ D EA LA N K L + + KS
Sbjct: 2058 ITKENLAQAVEHRKKAQAELASFKVLLDD---TQSEAARVLADNLKLKKELQSNKESVKS 2114
Query: 610 GRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFI 669
L +EK+ + QE ++ L+R+ + + I
Sbjct: 2115 QMKQKDEDLERRLEQAEEKH---------------LKEKKNMQEKLDALRREKVHLEETI 2159
Query: 670 GLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAY 729
G ++ + K Q EN D + Q F + + D+ D+ A
Sbjct: 2160 GEIQVTLNKKDKEVQQLQENL----------DSTVTQLAAFTKSMSSLQDDRDRVIDEAK 2209
Query: 730 QKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKK 789
+ +R++ Q E+ + V+K ++ + I EE+ S+L++D
Sbjct: 2210 KWERKFSDAI---QSKEEEIRLKEDNCSVLKDQLRQ---MSIHMEELKINISRLEHDK-- 2261
Query: 790 AMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLAT 849
QI E K Q E ++ ++++ +TL+ + +E+ +L N LA
Sbjct: 2262 --QIWESKAQTEVQL------QQKVCDTLQGENKELLSQLEETRHL----YHSSQNELAK 2309
Query: 850 APDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLD-- 907
+ + K L++ ++ + E+ G +E +++ +I N K +Q + D
Sbjct: 2310 L--ESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE---ADIQNSKFSYEQLETDLQ 2364
Query: 908 -----------KINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVD 956
+IN + + S ++ + AI+ A L++ D KEIK+ E +
Sbjct: 2365 ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHD------KEIKELENLLS 2418
Query: 957 DLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDA----- 1011
E LE++ + V TN E+L I+KE+ +L ++ +LQ D
Sbjct: 2419 QEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
Query: 1012 ---------LSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPED 1062
LSI L+ +Q+ A N+K+K +EI + H ++D E + D
Sbjct: 2479 DYQQLEERHLSIILEKDQLIQEAAAENNKLK---EEIRGLRSH-MDDLNSENAKL----D 2530
Query: 1063 LEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELD----KITYERD 1118
E I+ + + I + + ++ K+ E+ LQ+ EL+ K+ +
Sbjct: 2531 AELIQYREDLNQVITIKD-------------SQQKQLLEVQLQQNKELENKYAKLEEKLK 2577
Query: 1119 SFRQAYEDLRK 1129
+A EDLR+
Sbjct: 2578 ESEEANEDLRR 2588
Score = 96.3 bits (238), Expect = 2e-19
Identities = 225/1129 (19%), Positives = 458/1129 (40%), Gaps = 172/1129 (15%)
Query: 105 HKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDEHKDIQSCTVEVHF 164
HK S ++ + + L + G RA++ + L E + I ++V
Sbjct: 556 HKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKV-- 613
Query: 165 QKIIDKEGDDYEVIPNSNFYVSRTACRDNTSVYHIS--GKKKTFKDVGNLLRSHGIDLDH 222
++ G D+ ++PN + ++ S H S ++ + D G L+S D D
Sbjct: 614 --FLEDTGQDFPLMPNEESSLPAVE-KEQASTEHQSRTSEEISLNDAGVELKSTKQDGDK 670
Query: 223 NRFLI-------------LQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKV 269
+ + L+ ++ ++ + K Q +++ + E ++I +L E K
Sbjct: 671 SLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKK 730
Query: 270 LCRR----VEILNEHRGEKLNRVK-------------MVEKEKDALEGEKNIAIEFLTLE 312
L+E R + L++VK +E E ++ + E T
Sbjct: 731 NADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAH 790
Query: 313 NEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNI---LSNEMKAKNKDV 369
+ + ++ H E + + ++E + ++ + + +E+S + L ++++ K +V
Sbjct: 791 DNLLTEQIHSLSI---EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEV 847
Query: 370 KDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKV---- 425
+ +++ I+ +EE + +Q +LE ++ + L + L++ +++ ++V
Sbjct: 848 LEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEIS 907
Query: 426 -----------EEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGL 474
EE S+ + + + + A E +KE+ E+ EV LKQ +
Sbjct: 908 FSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEED-NEVSSGLKQNYDEM 966
Query: 475 ----QKEKESREKELMGFSKSVNEARSKMDVA---QSELDIYLSRHNTAVSQLTKAKEAL 527
Q KE + E K + + K+ A + EL +SR ++ L +
Sbjct: 967 SPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKE 1026
Query: 528 IAASETLKERKAAIRDIEGKLPQTEQELKEKEKEL-----QKLTQEETNFKSLVHDLFQK 582
I SET ER D E K +E+ + K +E+ Q ++++E + + DL +K
Sbjct: 1027 IPLSET--ERGEVEEDKENK-EYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEK 1083
Query: 583 VEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDY 642
+ + A+ + + L + K+ +I + + + AI +K I+S A D
Sbjct: 1084 LAAEEQFQALVKQMNQTL-----QDKTNQIDLLQAEISENQAIIQK---LITSNTDASD- 1134
Query: 643 IVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDE 702
DS+ + +E V ++ +E PE ++ L K K++
Sbjct: 1135 --GDSVALVKETV-----------------VISPPCTGSSEHWKPELEEKILALEKEKEQ 1175
Query: 703 ---KIRQAFYFALRDTLVADNLDQATR--VAYQKDRRWRVVTLQGQIIEQSGTMTGGGSK 757
K+++A A ++ R + QKD R LQ Q EQS G +
Sbjct: 1176 LQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNR---LQEQFDEQSKENENIGDQ 1232
Query: 758 VMKGRMGSSLVIEISEEEVNKMESQLQNDS-----------KKAMQIQEQKVQLEERVVK 806
+ + L I++ E K+ S Q +S KA + + LE +
Sbjct: 1233 LRQ------LQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCP 1286
Query: 807 LRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPD--KKKQKLLEENVS 864
S E + L+ T S+ ++ Q + + + ELE V +T + KK +++ +
Sbjct: 1287 DWPSHSEDASALQGGT-SVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQ 1345
Query: 865 AFKTEYDAVAEKAGKVEAEV------KRLHNTIVEINN-HKLKAQQDKLDKINK------ 911
K + + K EAEV ++L ++ ++I L+ Q KLD++ K
Sbjct: 1346 INKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKE 1405
Query: 912 --------QLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELK 963
QL E +A+TK Q I +L KA + L E + K+ ++ + L EL
Sbjct: 1406 EDVSYLSGQLSEKEAALTKIQTEI-IEQEDLIKALHTQL--EMQAKEHDERIKQLQVELC 1462
Query: 964 SLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDG 1023
++ K E+ + + A ++ ++Q L+ + ++EN+ +LQ++ + +E++
Sbjct: 1463 EMKQKPEEIGEESRAKQQIQRKLQAA---LISRKEALKENK-SLQEELSLARGTIERLTK 1518
Query: 1024 HIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARC 1083
+A+ S++ +KE +D + +++L E + I D + L + C
Sbjct: 1519 SLADVESQVSAQNKE---------KDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSC 1569
Query: 1084 HEMKPNLGAIAEYKKK-----EELYLQRVAELDKITYERDSFRQAYEDL 1127
+K L + E K+K E L ++AE + + ++ YE L
Sbjct: 1570 ESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEIL 1618
Score = 93.2 bits (230), Expect = 1e-18
Identities = 186/1037 (17%), Positives = 424/1037 (40%), Gaps = 122/1037 (11%)
Query: 228 LQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGR----------LNEPIKVLCRRVEIL 277
L+ E +Q+ K K ++E + EYLE I G + L E +K + V+ L
Sbjct: 1968 LEEEKQQLVKEKTKVESEIRK---EYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQL 2024
Query: 278 NEHRGEKLNRVKMVEKEKDALE-----GEKNIAIEFLTLENEIFRKKNHVCQYYIYELQK 332
+ ++ +E+ ALE +K++ I L + +K Q + +
Sbjct: 2025 QKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKK--AQAELASFKV 2082
Query: 333 RIAEMETQKEKIHEDT----KEINEKSNILSNEMKAKNKDVKDTEKKLNKIT-KFIEENK 387
+ + +++ ++ D KE+ + ++MK K++D+ E++L + K ++E K
Sbjct: 2083 LLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDL---ERRLEQAEEKHLKEKK 2139
Query: 388 ---EKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTT 444
EK L E V + E + K +K++Q+ +E ++ + A ++
Sbjct: 2140 NMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Query: 445 RNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQS 504
+ + E +K E+K + + S ++E + + + +L S + E + + +
Sbjct: 2200 DRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEH 2259
Query: 505 ELDIYLSRHNTAVSQLTKAKEALIAASETL----KERKAAIRDIEGKLPQTEQELKEKEK 560
+ I+ S+ T V K + L ++ L +E + + +L + E ELK +
Sbjct: 2260 DKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKD 2319
Query: 561 EL-------QKLTQEETNFKSLVHDLFQKVEEAKSS---LAMNRSRGKVLDAIIQEKKSG 610
+L +K +++ N + ++ ++ +K S L + + L + + E+ +
Sbjct: 2320 QLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINM 2379
Query: 611 RIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIG 670
+ I + L +E VAI+ D + +E N L ++
Sbjct: 2380 KEQKI---ISLLSGKEEAIQVAIAELRQQHDKEI-------KELENLLSQEEEENIVLEE 2429
Query: 671 LDKMAVWAKKMTEIQTPENTPRLFDLVK-VKDEKIRQ-----AFYFAL------RDTLVA 718
+K AV + T +L + +K +K E I+Q +F ++ RD +V
Sbjct: 2430 ENKKAV-----------DKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVG 2478
Query: 719 DNLDQATRVAYQK--DRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMG---------SSL 767
D YQ+ +R ++ + Q+I+++ + ++G + L
Sbjct: 2479 D---------YQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKL 2529
Query: 768 VIEISE--EEVNKMESQLQNDSKKAMQIQ-EQKVQLEERVVKLRHSEREMRNTLEKFTAS 824
E+ + E++N++ + + K+ +++Q +Q +LE + KL +E E S
Sbjct: 2530 DAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRS 2589
Query: 825 IQRLIEQEEYLNVQVKELEANV------LATAPDKKKQKLLEENVSAFKTEYDAVAEKAG 878
L E+++ L+ +++ L+ ++ + ++ L + + E ++
Sbjct: 2590 FNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFS 2649
Query: 879 KVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQ 938
+ + L +V + K + DK+ K+L + +TA+ + +
Sbjct: 2650 SSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELA 2709
Query: 939 DSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELK 998
++ E+++ KE LTA+++S + + + + A E L E+++++ L+EL
Sbjct: 2710 RDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELA 2769
Query: 999 VI-------QENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNP 1051
+ +E + L + A S+ E H+ + N ++ +++ +S +ED+
Sbjct: 2770 QLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLS-SQLEDS- 2827
Query: 1052 IEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELD 1111
++ S D + N++ + E K A E L++ +
Sbjct: 2828 YNQVQSFSKAMASLQNERDHLWNELEKFR-KSEEGKQRSAAQPSTSPAEVQSLKKA--MS 2884
Query: 1112 KITYERDSFRQAYEDLRKQ--RLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLDP 1169
+ +RD + ++L++Q ++N+ + + + +L+E YQ T E + +
Sbjct: 2885 SLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQE-YQDKTKAFQIMQEELRQENL 2943
Query: 1170 FSEGIMFSVRPPKKSWK 1186
+ + +R K SW+
Sbjct: 2944 SWQHELHQLRMEKSSWE 2960
Score = 89.7 bits (221), Expect = 2e-17
Identities = 155/825 (18%), Positives = 342/825 (41%), Gaps = 126/825 (15%)
Query: 273 RVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQK 332
++ +LN+ E+L+RV K K+ E EK+ E L
Sbjct: 1893 KMNLLNQQIQEELSRVT---KLKETAEEEKDDLEE---------------------RLMN 1928
Query: 333 RIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQ 392
++AE+ +D + K+ +L +EMK K V + E++ ++ K + + + +
Sbjct: 1929 QLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRK 1988
Query: 393 LDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKE 452
LE +Q +K S AK+L++ L++ +++V++ + + I+ ALE
Sbjct: 1989 EYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFV 2048
Query: 453 KEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSR 512
+ + +K L+ ++L Q + ++ + EL F + +D QSE L+
Sbjct: 2049 QTESQKDLEITKENLAQAVE----HRKKAQAELASF-------KVLLDDTQSEAARVLAD 2097
Query: 513 HNTAVSQLTKAKEALIAASETLK-ERKAAIRDIEGKLPQTEQE-LKEK---EKELQKLTQ 567
+ K K+ L + E++K + K D+E +L Q E++ LKEK +++L L +
Sbjct: 2098 N-------LKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRR 2150
Query: 568 EETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDE 627
E+ + + + ++ + +N+ +V +QE + + + ++ +
Sbjct: 2151 EKVHLEETIGEI---------QVTLNKKDKEVQQ--LQENLDSTVTQLAAFTKSMSSLQD 2199
Query: 628 KYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTP 687
D I + D+I +E + LK N V D++ + M E++
Sbjct: 2200 DRDRVIDE-AKKWERKFSDAIQSKEEEIR-LKEDNCSVLK----DQLRQMSIHMEELKI- 2252
Query: 688 ENTPRLFDLVKVKDEKIRQAFYFALR--DTLVADNLD-----QATRVAYQKDR------R 734
N RL ++ + K + + DTL +N + + TR Y +
Sbjct: 2253 -NISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLE 2311
Query: 735 WRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSL-----VIEISEEEVNKMESQLQNDSKK 789
+ +L+ Q+ + S ++ K KG + + I+ S+ ++E+ LQ +
Sbjct: 2312 SELKSLKDQLTDLSNSLE--KCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASREL 2369
Query: 790 AMQIQEQKVQLEERVVKLRHSER--------EMRNTLEKFTASIQRLIEQEEYLNVQVKE 841
++ E+ E++++ L + E+R +K ++ L+ QEE N+ ++E
Sbjct: 2370 TSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEE 2429
Query: 842 LEANVLATAPDKKKQ------KLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEIN 895
A DK Q + +EN+ K + D+ + ++ + R+ ++
Sbjct: 2430 ENKK----AVDKTNQLMETLKTIKKENIQQ-KAQLDSFVKSMSSLQNDRDRIVGDYQQLE 2484
Query: 896 NHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEV 955
L +K ++ + E A+ K + I+ ++ + + E+ +++
Sbjct: 2485 ERHLSIILEK----DQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDL 2540
Query: 956 DDLTAELKSLEDKAAEVVKNTN--------AAEESLPEIQKEHRNLLQELKVIQENEHAL 1007
+ + S + + EV N EE L E ++ + +L + +QE + L
Sbjct: 2541 NQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDL 2600
Query: 1008 QKDALSIKLKLEQI---------DGHIAEHNSKIKYWHKEISKIS 1043
K+ S+K+ + Q+ +G + +++++K +E+ ++S
Sbjct: 2601 SKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLS 2645
Score = 83.2 bits (204), Expect = 1e-15
Identities = 214/1022 (20%), Positives = 413/1022 (40%), Gaps = 149/1022 (14%)
Query: 219 DLDHNRFLILQGEVEQIAMMKPKGQTEHD-EGMLEYLEDIIGCGRLNEPIKVLCRRVEIL 277
D D N L E+ Q + M+ T+ D + L Y E ++ +K + R+ ++
Sbjct: 21 DTDQNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLV------VELKDIIRQKDV- 73
Query: 278 NEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEM 337
++++ +AL+ E+ A +N+I + K H + + L K I EM
Sbjct: 74 ------------QLQQKDEALQEERKAA------DNKIKKLKLHA-KAKLTSLNKYIEEM 114
Query: 338 ETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLED 397
+ Q + + E ++ +K + E ++ KI ++E +E + L +
Sbjct: 115 KAQGGTVLPTEPQSEE-------QLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQL 167
Query: 398 VQVR-EKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKE 456
Q + E+ ++++ ++ Q+ +EK E ++ A+ + E + EK+ E
Sbjct: 168 TQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFE 227
Query: 457 EK-KLKE-----------VMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQS 504
+ +L E V ++Q+ + LQ++ E E+ L+G ++ V D+ Q
Sbjct: 228 TQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVV-------DLLQQ 280
Query: 505 ELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQK 564
EL R+ QL + + A TL+ R+ E K+ + EL+ E++L
Sbjct: 281 ELTAAEQRNQILSQQLQQME----AEHNTLRNTVETERE-ESKILLEKMELEVAERKLSF 335
Query: 565 LTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDA------------IIQEKKSGR- 611
N + +H L ++ E+A + A SR L+ I+ +K+G+
Sbjct: 336 -----HNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQE 390
Query: 612 IPGIYGRLGDLGA--IDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFI 669
+ L D + + +K + A+ S + + ++E FL R +
Sbjct: 391 LQSACDALKDQNSKLLQDKNEQAVQSA-QTIQQLEDQLQQKSKEISQFLNRLPLQQHETA 449
Query: 670 GLDKMAVWAKKMTEIQTPENTPRLFD-LVKVKDEKIRQAFYFALRDTLVADNLDQATRVA 728
+ T+ T EN L +V++++EK + L A+N ++++
Sbjct: 450 SQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQIT 509
Query: 729 Y--------QKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMG------SSLVIEISEE 774
+ DR +++ ++S + G V++ S L++E+ E
Sbjct: 510 LLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEA 569
Query: 775 EVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSER----EMRNTLEKFTASIQRLIE 830
+ +LQ K+A + + L+++ +K E +M+ LE +
Sbjct: 570 QEEIAFLKLQLQGKRAEEADHEV--LDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPN 627
Query: 831 QEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYD------AVAEKAGKVEAEV 884
+E L KE +A+ + ++ L + V T+ D AV + + E+
Sbjct: 628 EESSLPAVEKE-QASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDEL 686
Query: 885 KRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAI----KTADRN------L 934
+RL + I+E+ + KAQ+ K LDE A I+ I K AD N L
Sbjct: 687 ERLKSQILELELNFHKAQEI----YEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTAL 742
Query: 935 QKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLL 994
+ +D +L KE+ V +L A++K LE AE + ES Q H NLL
Sbjct: 743 SEERDQLLSQVKELS----MVTELRAQVKQLEMNLAEAERQRRLDYES----QTAHDNLL 794
Query: 995 QELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEE 1054
E H+L +A S +K+E + + + ++++ + SL N E
Sbjct: 795 TE------QIHSLSIEAKSKDVKIEVLQNELDD--VQLQFSEQSTLIRSLQSQLQNKESE 846
Query: 1055 ISVLSPEDLEAIKNPDSITNQIA-LLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDK- 1112
+ E E +++ S +++ L + E+ + E K+ E Q + E D+
Sbjct: 847 VL----EGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQ 902
Query: 1113 ITYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLDPFSE 1172
+T S + L +++ F G I T LKE +L+ +A+ E V+ + S
Sbjct: 903 VTEISFSMTEKMVQLNEEK---FSLGVEIKT--LKEQLNLLSRAEEAKKEQVEEDNEVSS 957
Query: 1173 GI 1174
G+
Sbjct: 958 GL 959
Score = 82.8 bits (203), Expect = 2e-15
Identities = 179/931 (19%), Positives = 375/931 (40%), Gaps = 169/931 (18%)
Query: 334 IAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQL 393
+A+++ Q ++I + E+ K + ++E+ K+++V ++++NK IE K +
Sbjct: 1304 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEA 1363
Query: 394 DLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEK 453
++ +++KL+ + + LE L++ + K++E + + +K ++ + + + E
Sbjct: 1364 EVHAESLQQKLESSQLQIAGLE-HLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAAL 1422
Query: 454 EKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRH 513
K + ++ E D +K L+ + + ++ + + E + K + E SR
Sbjct: 1423 TKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEE-----SRA 1477
Query: 514 NTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFK 573
+ + K + ALI+ E LKE K+ ++EL +++LT+ + +
Sbjct: 1478 KQQIQR--KLQAALISRKEALKENKS-----------LQEELSLARGTIERLTKSLADVE 1524
Query: 574 SLVHDLFQKVEEAKSSLAMNRSRGKVLD--AIIQEKKSGRIPGIYGRLGDLGAIDEKYDV 631
S V A N+ + VL A++QE++ I + D ++ +
Sbjct: 1525 SQVS-------------AQNKEKDTVLGRLALLQEERDKLITEM-----DRSLLENQ--- 1563
Query: 632 AISSCCH----ALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTE---- 683
++SS C AL+ + D + +E + LK I +T W +K E
Sbjct: 1564 SLSSSCESLKLALEGLTEDKEKLVKE-IESLKSSKIAEST--------EWQEKHKELQKE 1614
Query: 684 ----IQTPENTPRLFDLVKVKDEKIR---QAFYFALRDT-----LVADNLDQATRV---- 727
+Q+ EN + ++ E +R Q Y LR T L +A +
Sbjct: 1615 YEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEM 1674
Query: 728 -----AYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEIS-EEEVNKMES 781
+ K ++ +++ L+ + + G K M + L S +EE+ +++
Sbjct: 1675 KEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD-TAKECMETLLSSNASMKEELERVKM 1733
Query: 782 QLQNDSKKAMQIQEQKVQLEERVVKLRH----------------SEREMRNTLEKFTASI 825
+ + SKK + +K L E V L+H N E+ T SI
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793
Query: 826 QRLIEQEEYLNVQVK----ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVE 881
E+++ L++ + E + + P K + ++ + + D + E+ +E
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853
Query: 882 AEVKRLHNTIVEINNHK----------------LKAQQDKLDKINKQLDECASAITKAQV 925
E ++ + N K L+ + K++ +N+Q+ E S +TK +
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLK- 1912
Query: 926 AIKTADRNLQKAQDSVLR----------------TEKEIKD--TEKEVDDLTAELKSLED 967
+TA+ ++ ++ T+ +IK+ E E+ +L + LE+
Sbjct: 1913 --ETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEE 1970
Query: 968 KAAEVVKNTNAAE-----ESLPEIQ--------KEHRNLLQE-LKVIQENEHALQKDALS 1013
+ ++VK E E L +IQ K H LQE LK Q+ LQKD +
Sbjct: 1971 EKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIR 2030
Query: 1014 IKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNP---D 1070
+ K+ + E K + + S+ L ++N + + E D
Sbjct: 2031 YQEKISAL-----ERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLD 2085
Query: 1071 SITNQIALLEARCHEMKPNL-----GAIAEYKKKEELYLQRVAEL-DKITYERDSFRQAY 1124
++ A + A ++K L ++ K+K+E +R+ + +K E+ + ++
Sbjct: 2086 DTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL 2145
Query: 1125 EDLRKQR--LNEFMAGFYIITNKLKENYQML 1153
+ LR+++ L E + + NK + Q L
Sbjct: 2146 DALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176
Score = 66.2 bits (160), Expect = 2e-10
Identities = 74/375 (19%), Positives = 155/375 (41%), Gaps = 36/375 (9%)
Query: 244 TEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKN 303
T+ E + + E I G E +K + E+ E +KL ++ + LE +
Sbjct: 1333 TKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQL---QIAGLEHLRE 1389
Query: 304 IAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMK 363
+ + L+ I +K+ V L +++E E KI + E + L +++
Sbjct: 1390 LQPKLDELQKLISKKEEDVSY-----LSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLE 1444
Query: 364 AKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKL-------KHATSKAKKLEK 416
+ K+ + K+L +++ E+ + Q++ KL K A + K L++
Sbjct: 1445 MQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQE 1504
Query: 417 QLQKDKEKVEEF-KSIPAKSNNIINETTTRNNAL------EKEKEK----------EEKK 459
+L + +E KS+ + + + ++ L ++E++K E +
Sbjct: 1505 ELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQS 1564
Query: 460 LKEVMDSLKQETQGLQKEKESREKELMGFSKSV----NEARSKMDVAQSELDIYLSRHNT 515
L +SLK +GL ++KE KE+ S E + K Q E +I L +
Sbjct: 1565 LSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYEN 1624
Query: 516 AVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSL 575
++ + + + A + +E +R E +TE++L+E E+E++++ ++ F
Sbjct: 1625 VSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKS 1684
Query: 576 VHDLFQKVEEAKSSL 590
++EE L
Sbjct: 1685 KQQKILELEEENDRL 1699
Score = 40.0 bits (92), Expect = 0.014
Identities = 59/302 (19%), Positives = 135/302 (44%), Gaps = 31/302 (10%)
Query: 291 VEKEKDALEGE-KNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTK 349
++ ++D L E KN+ ++L + EI + H + + E Q + + +E++ ++
Sbjct: 2886 LQNDRDRLLKELKNLQQQYLQINQEI--TELHPLKAQLQEYQDKTKAFQIMQEELRQENL 2943
Query: 350 EINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATS 409
+ + L M+ + ++ + K +++ +K QL +RE L+ ++S
Sbjct: 2944 SWQHELHQL--RMEKSSWEIHERRMK----EQYLMAISDKDQQLSHLQNLIRE-LRSSSS 2996
Query: 410 KAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETT---TRNNALEKEKEKEEKKLKEVMDS 466
+ + L+ Q Q+ E + P S N++ ET T+ N KE ++E +++++ +
Sbjct: 2997 QTQPLKVQYQRQASP--ETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSN 3054
Query: 467 LKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEA 526
Q L +EK + +L S+S+ E + + + L K +
Sbjct: 3055 FSQ----LLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAV-----------LEKQVQE 3099
Query: 527 LIAASETLKERKAAIRDIEGKLPQTE-QELKEKEKELQKLTQEETNFKSLVHDLFQKVEE 585
L A + A ++ G +++ +EL+E ++ + Q+ N + V++L + +EE
Sbjct: 3100 LQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEE 3159
Query: 586 AK 587
+
Sbjct: 3160 ER 3161
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 99.0 bits (245), Expect = 3e-20
Identities = 189/936 (20%), Positives = 383/936 (40%), Gaps = 110/936 (11%)
Query: 231 EVEQIAMMKPKGQTEHDEGMLEYL--EDIIGCGRLNEPIKVLCRRVEILNEHRGEKLNR- 287
+++Q K Q H + ++ + E + R + +K ++E+L + R + L
Sbjct: 716 KMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEH 775
Query: 288 ---VKMVEKEKDALEGEKNIA---IEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQK 341
V+ +E + EGE A ++ ++ + + +LQ+++ ++ET++
Sbjct: 776 QAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETER 835
Query: 342 EKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQL-------- 393
+ + E+ + + E+ A V+D ++L K +E+ + TQ+
Sbjct: 836 ILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDG 895
Query: 394 DLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINET-TTRNNALEKE 452
+ E Q ++ L + ++ + +K+ E + + S S +I+NE T+ EK+
Sbjct: 896 NKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKK 955
Query: 453 KEKEEKKLKEVMDSLKQ----ETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDI 508
EK ++K KE+ ++LK+ + L+KE E+ EL K N +M A S
Sbjct: 956 MEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANS---- 1011
Query: 509 YLSRHNTAVSQL-TKAKEALIAASET-LKERKAAIRDIEGKLPQTEQELKE-KEKELQKL 565
+ + AVS+L T KE + + +E +E I E KL Q +EL+E E +LQ+
Sbjct: 1012 --AGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEK 1069
Query: 566 TQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQE------KKSGRIPGIYGRL 619
QE K + + EE + + G D + E +KS + +
Sbjct: 1070 EQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDE 1129
Query: 620 GDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAK 679
L A EK +V ++ + + FL+ Q + + DK +
Sbjct: 1130 TKLKAHLEKLEVDLNK---------------SLKENTFLQEQLVELKMLAEEDK-----R 1169
Query: 680 KMTEIQTP-ENTPRLFDLVKVKDEKIRQAFY-FALRDTLVADNLDQATRVAYQKDRRWRV 737
K++E+ + + T F +K EK ++ +L +++ L + +K
Sbjct: 1170 KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLE 1229
Query: 738 VTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIE---ISEEEVNKMESQLQNDSKKAMQIQ 794
I S S++ + ++ V E I V+++E+QL+ Q+
Sbjct: 1230 AKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR-------QLT 1282
Query: 795 EQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANVLATAPDKK 854
E++ L + H E N ++ A I+ L+ ++E L + N A +K+
Sbjct: 1283 EEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKE----GGNQQQAASEKE 1338
Query: 855 K-----QKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNH-KLKAQQDKLDK 908
+K L EN++A + + EK ++ + K+L + V++ N L ++ +
Sbjct: 1339 SCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISS 1398
Query: 909 INKQLDE--C------------ASAITKAQV-AIKTADRNLQKAQDSVLRTEKEIKDTEK 953
+ KQ DE C ++K ++ A++ D K + + + +
Sbjct: 1399 LRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQN 1458
Query: 954 EVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELK----VIQENEHALQK 1009
V +L +L+ +A E + N +E L + K L E++ +++ E L+
Sbjct: 1459 TVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLET 1518
Query: 1010 DALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISL-----HPIEDNPIEEISVLSPEDLE 1064
+ S ++ +++ HI + +I+ ++ + + H ++ L E
Sbjct: 1519 ELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDN 1578
Query: 1065 AIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKE 1100
+K + +I LE + + MK L E KKKE
Sbjct: 1579 RVKEAE---EKILTLENQVYSMKAEL----ETKKKE 1607
Score = 96.3 bits (238), Expect = 2e-19
Identities = 161/823 (19%), Positives = 363/823 (44%), Gaps = 109/823 (13%)
Query: 329 ELQKRIAEMETQKE-KIHEDTK---EINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIE 384
+L +R+ E+E K+ + E TK ++ + N++ + K + +T++++++ + E
Sbjct: 322 QLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKE 381
Query: 385 ENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDK----EKVEEFKSIPAKS----N 436
E E Q+R ++K T++ ++L +Q +K + E++E+ S K+
Sbjct: 382 E----------EIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431
Query: 437 NIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKE---------KESREKELMG 487
+ E + +EK E+E L++ + +KQE + K+ ++ EKEL
Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKEL-- 489
Query: 488 FSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGK 547
++ E K+ + E + V+ E L + E ++ A+ ++E
Sbjct: 490 -ARKEQELTKKLQTREREF-----QEQMKVALEKSQSEYLKISQEKEQQESLALEELE-- 541
Query: 548 LPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEK 607
Q + L E E +L+ L QE +++ + +L +E+ SL N+++ K L ++ +
Sbjct: 542 -LQKKAILTESENKLRDLQQEAETYRTRILELESSLEK---SLQENKNQSKDLAVHLEAE 597
Query: 608 KSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIA----QECVNFLKRQNI 663
K+ ++ + EK+ + S H D + + + + Q + L+ +
Sbjct: 598 KNKHNK-------EITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCE 650
Query: 664 GVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQ 723
+ DK ++ + E+ E T D+ + + E + L+ L++
Sbjct: 651 QEKETLLKDKEIIFQAHIEEMN--EKTLEKLDVKQTELESLSSELSEVLK---ARHKLEE 705
Query: 724 ATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEIS-EEEVNKMESQ 782
V + + + L+ ++ EQ ++K S E + ++++N++E
Sbjct: 706 ELSVLKDQTDKMK-QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELL 764
Query: 783 LQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKEL 842
L+ K ++E + +E ++ SE E L++ +A + + + Q K
Sbjct: 765 LKERDK---HLKEHQAHVENLEADIKRSEGE----LQQASAKLDVFQSYQSATHEQTKAY 817
Query: 843 EANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQ 902
E + + +QKLL+ +TE + ++ +VEA+ K + E++ HK++ Q
Sbjct: 818 EEQLA-----QLQQKLLD-----LETERILLTKQVAEVEAQKK---DVCTELDAHKIQVQ 864
Query: 903 --QDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKE------IKDTEKE 954
+L+K N ++++ ++T+ + K D N ++ Q + EKE + +KE
Sbjct: 865 DLMQQLEKQNSEMEQKVKSLTQVYES-KLEDGNKEQEQTKQILVEKENMILQMREGQKKE 923
Query: 955 VDDLTAELKSLEDKA----AEVVKNTNAAEESLPEIQKEHRNLLQEL-KVIQENEHALQK 1009
++ LT +L + ED E E+ + +++++ + + + L K + + E L+K
Sbjct: 924 IEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKK 983
Query: 1010 DALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIK-- 1067
+ + L+L Q + + N+K+ E+++ + I D + + E +E++
Sbjct: 984 ELENTALELSQKE---KQFNAKM----LEMAQANSAGISD-AVSRLETNQKEQIESLTEV 1035
Query: 1068 NPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAEL 1110
+ + + I++ E + ++ L I E + +E+ Q VAEL
Sbjct: 1036 HRRELNDVISIWEKKLNQQAEELQEIHEIQLQEK--EQEVAEL 1076
Score = 92.0 bits (227), Expect = 3e-18
Identities = 187/958 (19%), Positives = 400/958 (41%), Gaps = 94/958 (9%)
Query: 286 NRVKMVEKEKDALEGEKNIAIEFLTLE-NEIFRKKNHVCQYYIYELQKRIAEMETQKEKI 344
N+ + +E + E N I + N+ + + + + E ++ +AE++ +
Sbjct: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
Query: 345 HEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKL 404
+ +E+N++ L E ++ + + +++L + + + + T+L ++ L
Sbjct: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDL 1143
Query: 405 KHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVM 464
+ + L++QL + K EE K ++ + + T +L+ EK K L++
Sbjct: 1144 NKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKS 1203
Query: 465 DSLKQETQGLQKEKESREKELMGFSKSVNEARSK--MDVAQSELDIYLSRHNTAVSQLTK 522
K+ ++ L + + K+ ++++ EA++ ++++ S+ + LSR + + TK
Sbjct: 1204 LEFKKLSEELAIQLDICCKK----TEALLEAKTNELINISSSKTNAILSRISHCQHRTTK 1259
Query: 523 AKEALIAASETLKERKAAIRDIEGK-------LPQTEQELKEKEKEL------------- 562
KEAL+ + T+ E +A +R + + Q +L+EKE ++
Sbjct: 1260 VKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTE 1319
Query: 563 -QKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGD 621
+ L +E N + + + + K L+ N + ++ ++EKK I + +L D
Sbjct: 1320 KEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKV-EISSLSKQLTD 1378
Query: 622 LG-------AIDEKYDVAISSCCHALDYIVVDSIDIAQEC---VNFLKRQNIGVATFIG- 670
L ++ EK + AISS D + +D Q+ V+ L ++ I +
Sbjct: 1379 LNVQLQNSISLSEK-EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDD 1437
Query: 671 -LDKMAVWAKK-MTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVA 728
+K + W KK + +NT + +L + K ++A+ + L+ + LDQ +
Sbjct: 1438 WSNKFSEWKKKAQSRFTQHQNTVK--ELQIQLELKSKEAYEKDEQINLLKEELDQQNK-- 1493
Query: 729 YQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSK 788
R L+G++ + M S + + I E+ + + ++++ ++
Sbjct: 1494 -------RFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNE 1546
Query: 789 KAMQIQEQK-VQLEERVVKLRH-------SEREMRNTLEKFTASIQRLIEQEEYLNVQVK 840
+QK ++ +E V KL+H + ++ EK ++ + L + K
Sbjct: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
Query: 841 ELEANVLATAPDKKKQKLLE---ENVSAFK-TEYDAVAEKAGKVEAEVKRLHNTIVEINN 896
ELE L+ +++ K LE E+ SA K E AE+ K+ A K+L + + E
Sbjct: 1607 ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ--KIAAIKKQLLSQMEEKEE 1664
Query: 897 HKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIK--DTEKE 954
K + L ++N +L E + + +K+ + + Q V R+ K + ++E
Sbjct: 1665 QYKKGTESHLSELNTKLQEREREVHILEEKLKSVESS-QSETLIVPRSAKNVAAYTEQEE 1723
Query: 955 VDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSI 1014
D K+ E+K + + +N E+ L + +E +E V E Q I
Sbjct: 1724 ADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQE-----KEETVSSHFEMRCQYQERLI 1778
Query: 1015 KLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKN----PD 1070
KL+ + H E S I + +E+ E N + V + E KN
Sbjct: 1779 KLEHAEAKQH--EDQSMIGHLQEELE-------EKNKKYSLIVAQHVEKEGGKNNIQAKQ 1829
Query: 1071 SITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQ 1130
++ N ++ E + + + K+ + L R E+ ++ E + YE L Q
Sbjct: 1830 NLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRV--EMEELTSKYEKL--Q 1885
Query: 1131 RLNEFMAGFYIITNKLKENYQMLTLGGDAELELVDSLDPFSEGIMFSVRPPKKSWKKI 1188
L + M G T L+EN + + + +L+ +++ + F + ++ +K+
Sbjct: 1886 ALQQ-MDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKL 1942
Score = 87.0 bits (214), Expect = 1e-16
Identities = 169/851 (19%), Positives = 351/851 (41%), Gaps = 134/851 (15%)
Query: 278 NEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEM 337
+E + E L++V+ + + D L EK A+E + + F + Q + Q + E+
Sbjct: 1404 DEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKEL 1463
Query: 338 ETQKEKIHEDTKEINEKSNILSNEMKAKNK-------DVKDTEKKLNKITKFIEENKEKF 390
+ Q E ++ E +E+ N+L E+ +NK +++D + K+ K +E
Sbjct: 1464 QIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLE------ 1517
Query: 391 TQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALE 450
T+L + ++ E H T K ++E L + + + K I K + + L
Sbjct: 1518 TELKSQTARIMELEDHITQKTIEIE-SLNEVLKNYNQQKDIEHKE---LVQKLQHFQELG 1573
Query: 451 KEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYL 510
+EK+ K+ +E + +L+ + ++ E E+++KEL + SV ++ + L+
Sbjct: 1574 EEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLE--- 1630
Query: 511 SRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEET 570
S +++L + E IAA +K + +E K Q ++ + EL QE
Sbjct: 1631 SESAAKLAELKRKAEQKIAAI-----KKQLLSQMEEKEEQYKKGTESHLSELNTKLQERE 1685
Query: 571 NFKSLVHDLFQKVEEAKS-SLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKY 629
++ + + VE ++S +L + RS V QE+ + G + + Y
Sbjct: 1686 REVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQ-----------GCVQKTY 1734
Query: 630 DVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDK-MAVWAKKMTEIQTPE 688
+ IS L E L+R +G +K V + Q E
Sbjct: 1735 EEKISVLQRNL-----------TEKEKLLQR--------VGQEKEETVSSHFEMRCQYQE 1775
Query: 689 NTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQS 748
L+K++ + +Q D + +L + +K++++ ++ Q +E+
Sbjct: 1776 R------LIKLEHAEAKQH-----EDQSMIGHLQEELE---EKNKKYSLIV--AQHVEKE 1819
Query: 749 GTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKV-QLEERVVKL 807
GG ++ + V + ++ + + E QI EQK+ +L+ +V+
Sbjct: 1820 -----GGKNNIQAKQNLENVFDDVQKTLQEKE--------LTCQILEQKIKELDSCLVRQ 1866
Query: 808 RHSEREMRNTLEKFTASIQRL--IEQEEYLNVQVKELEANVLATAPDKKKQKLLEEN-VS 864
+ R +E+ T+ ++L ++Q + N + LE N +K K L++ +S
Sbjct: 1867 KEVHRV---EMEELTSKYEKLQALQQMDGRNKPTELLEEN----TEEKSKSHLVQPKLLS 1919
Query: 865 AFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNH---KLKAQQDKLDKINKQLDECASAIT 921
+ +++ + K E E ++L IV + K Q +L+ + K+ D+
Sbjct: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQ------ 1973
Query: 922 KAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEVD-DLTAELKSLEDKAAEVVKNTNAAE 980
+ ++ Q+ +D L+ +K +E + L + + LE E + E
Sbjct: 1974 ------EREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE 2027
Query: 981 ESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEIS 1040
L E +E N Q LK I E + L++ A K E +D E +K++ +
Sbjct: 2028 AELLESHQEETN--QLLKKIAEKDDDLKRTA---KRYEEILDAREEEMTAKVRDLQTQ-- 2080
Query: 1041 KISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKE 1100
+EE+ + LE +NP + + + ++E + ++ I++ K KE
Sbjct: 2081 -----------LEELQKKYQQKLEQEENPGN--DNVTIMELQT-QLAQKTTLISDSKLKE 2126
Query: 1101 ELYLQRVAELD 1111
+ + +++ L+
Sbjct: 2127 QEFREQIHNLE 2137
Score = 86.3 bits (212), Expect = 2e-16
Identities = 193/912 (21%), Positives = 364/912 (39%), Gaps = 135/912 (14%)
Query: 290 MVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTK 349
MVEK K LE K+ T + ++ + Q Y E++K + E +KE + +D +
Sbjct: 608 MVEKHKTELESLKHQQDALWTEKLQVLK------QQYQTEMEKLREKCEQEKETLLKDKE 661
Query: 350 EINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATS 409
I + NE + DVK TE L ++ + E + +L+ E++ V LK T
Sbjct: 662 IIFQAHIEEMNEKTLEKLDVKQTE--LESLSSELSEVLKARHKLE-EELSV---LKDQTD 715
Query: 410 KAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQ 469
K K+ E + + D++K + + ++II E E ++ EK LK+ ++ L+
Sbjct: 716 KMKQ-ELEAKMDEQKNHHQQQV----DSIIKEH-------EVSIQRTEKALKDQINQLEL 763
Query: 470 ETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIA 529
+ K + + + + + ++ A ++LD++ S + +A + TKA E
Sbjct: 764 LLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQS-YQSATHEQTKAYE---- 818
Query: 530 ASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSS 589
E L + + + D+E + +++ E E + + + E K V DL Q++E+ S
Sbjct: 819 --EQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSE 876
Query: 590 LAMN-RSRGKVLDA--------------IIQEKKSGRIPGIYGRLGDLGAIDEKYDVAIS 634
+ +S +V ++ I+ EK++ + G+ ++ + +K A
Sbjct: 877 MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLS-AKE 935
Query: 635 SCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLF 694
H L+ +E K Q KM +K E+Q L
Sbjct: 936 DSIHILN----------EEYETKFKNQE---------KKMEKVKQKAKEMQETLKKKLLD 976
Query: 695 DLVKVKDEKIRQAFYFALRD-TLVADNLDQA-TRVAYQKDRRWRVVTLQGQIIEQSGTMT 752
K+K E A + ++ A L+ A A D R+ T Q + IE
Sbjct: 977 QEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE------ 1030
Query: 753 GGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSER 812
S R + VI I E+++N+ +LQ + +Q +EQ+V ++ + L E+
Sbjct: 1031 ---SLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEK 1087
Query: 813 EMRNTLEKFTASIQRLIEQEEYLN---VQVKELEANVLATAPDKKKQKLLEENVSAFKTE 869
E N ++ T + ++Q+ LN Q+K+ A+V + A D+ K K E K E
Sbjct: 1088 EEMN--KEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE-----KLE 1140
Query: 870 YDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKT 929
D K E L +VE+ K+ A++DK +++ E S +KT
Sbjct: 1141 VD-----LNKSLKENTFLQEQLVEL---KMLAEEDK-----RKVSELTS-------KLKT 1180
Query: 930 ADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAEL------------KSLEDKAAEVV---- 973
D Q + S ++ K ++D E L+ EL LE K E++
Sbjct: 1181 TDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISS 1240
Query: 974 KNTNAAEESLPEIQKEHRNLLQELKV-------IQENEHALQKDALSIKLKLEQIDGHIA 1026
TNA + Q + + L + ++ L ++ ++ + +Q +
Sbjct: 1241 SKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE 1300
Query: 1027 EHNSKIKYWHKEI-----SKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEA 1081
E ++IK +I K +L N + S + K N + L++
Sbjct: 1301 EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE 1360
Query: 1082 RCHEMKPNLGAIAEYKKKEELYLQRVAELDKITYERDSFRQAYEDLRKQRLNEFMAGFYI 1141
E K + ++++ + LQ L + S R+ Y++ + + L++ +
Sbjct: 1361 ELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFK 1420
Query: 1142 ITNKLKENYQML 1153
+ KE L
Sbjct: 1421 VDTLSKEKISAL 1432
Score = 76.3 bits (186), Expect = 2e-13
Identities = 164/923 (17%), Positives = 386/923 (41%), Gaps = 113/923 (12%)
Query: 255 EDIIG-CGRLNEP--IKVLCRRVEILNEHRG---EKLNRVKMVEKEKDALEG------EK 302
ED++G LN+ I+ L R L+ +RG E + +M+++EK L+G +K
Sbjct: 125 EDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDK 184
Query: 303 NIAIEFLTLENEIF---RKKNHVCQYYIYELQKR---IAEMETQKEKIHEDTKEINEKSN 356
++ L E+ + K H+ + + L+++ I+ ++TQ + + + +
Sbjct: 185 SLR-RIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVD 243
Query: 357 ILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEK 416
+L K + E + TK EEN E + +ED + L+ + K+ E
Sbjct: 244 VL--------KPLPQLEPQAEVFTK--EENPESDGEPVVEDGTSVKTLETLQQRVKRQEN 293
Query: 417 QLQKDKEKVEEFKS----IPAKSNNIINETTTRNNALEKEKE---KEEKKLKEVMDSLKQ 469
L++ KE ++ K + ++ + + R LEK K+ E+ KL + K
Sbjct: 294 LLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKN 353
Query: 470 ETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIA 529
+ L+++K M +++ + +++ + E+ SR + Q+T E L
Sbjct: 354 LIEQLEQDKG------MVIAETKRQMHETLEMKEEEIAQLRSR----IKQMTTQGEELRE 403
Query: 530 ASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSS 589
E K +AA ++E L T Q+ +E ++L+ E+ + + + EE + S
Sbjct: 404 QKE--KSERAAFEELEKAL-STAQKTEEARRKLKAEMDEQ------IKTIEKTSEEERIS 454
Query: 590 LAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSID 649
L SR K + +K S ++ L + EK +
Sbjct: 455 LQQELSRVKQEVVDVMKKSSEE------QIAKLQKLHEK--------------------E 488
Query: 650 IAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFY 709
+A++ K+ F K+A+ K +E + + +++ ++++
Sbjct: 489 LARKEQELTKKLQTREREFQEQMKVAL-EKSQSEYLKISQEKEQQESLALEELELQKKAI 547
Query: 710 FALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVM-------KGR 762
+ + D +A + R R++ L+ + E+S SK + K +
Sbjct: 548 LTESENKLRDLQQEA------ETYRTRILELESSL-EKSLQENKNQSKDLAVHLEAEKNK 600
Query: 763 MGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEK-- 820
+ + + + + + Q D+ ++Q K Q + + KLR + + TL K
Sbjct: 601 HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDK 660
Query: 821 ---FTASIQRLIEQE-EYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEK 876
F A I+ + E+ E L+V+ ELE+ + K + LEE +S K + D + ++
Sbjct: 661 EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE 720
Query: 877 AGKVEAEVKRLHNTIVE--INNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNL 934
E K H V+ I H++ Q+ + + Q+++ + + +K ++
Sbjct: 721 LEAKMDEQKNHHQQQVDSIIKEHEVSIQRTE-KALKDQINQLELLLKERDKHLKEHQAHV 779
Query: 935 QKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLL 994
+ + + R+E E++ ++D + + ++ + ++ L +++ E L
Sbjct: 780 ENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLT 839
Query: 995 QELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEE 1054
+++ ++ + + + + K++++ + + + NS+++ K ++++ +ED E+
Sbjct: 840 KQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQ 899
Query: 1055 ---ISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELD 1111
+L ++ ++ + +I +L + + ++ + E + E + + +++
Sbjct: 900 EQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNE--EYETKFKNQEKKME 957
Query: 1112 KITYERDSFRQAYEDLRKQRLNE 1134
K+ + ++ E L+K+ L++
Sbjct: 958 KV---KQKAKEMQETLKKKLLDQ 977
Score = 43.5 bits (101), Expect = 0.001
Identities = 49/216 (22%), Positives = 104/216 (48%), Gaps = 29/216 (13%)
Query: 262 RLNEPIKVLCRR----VEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLE-NEIF 316
RL + +++L + +EIL + ++ R + +++E++ LE + N ++ L E N
Sbjct: 1948 RLQKDLRMLRKEHQQELEILKKEYDQE--REEKIKQEQEDLELKHNSTLKQLMREFNTQL 2005
Query: 317 RKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKL 376
+K + I E + E+E + + H+ E++N L ++ K+ D+K T K+
Sbjct: 2006 AQKEQELEMTIKETINKAQEVEAELLESHQ------EETNQLLKKIAEKDDDLKRTAKRY 2059
Query: 377 NKITKFIEEN---KEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPA 433
+I EE K + Q LE++Q KK +++L++++ + +I
Sbjct: 2060 EEILDAREEEMTAKVRDLQTQLEELQ------------KKYQQKLEQEENPGNDNVTIME 2107
Query: 434 KSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQ 469
+ +TT +++ KE+E E ++ + D LK+
Sbjct: 2108 LQTQLAQKTTLISDSKLKEQEFRE-QIHNLEDRLKK 2142
Score = 32.3 bits (72), Expect = 3.0
Identities = 31/144 (21%), Positives = 57/144 (39%), Gaps = 25/144 (17%)
Query: 275 EILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRI 334
E+L H+ E +K + ++ D L+ E L E K Q + ELQK+
Sbjct: 2029 ELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKY 2088
Query: 335 AEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLD 394
+ Q+E D N + + + +L + T I ++K
Sbjct: 2089 QQKLEQEENPGND------------------NVTIMELQTQLAQKTTLISDSK------- 2123
Query: 395 LEDVQVREKLKHATSKAKKLEKQL 418
L++ + RE++ + + KK EK +
Sbjct: 2124 LKEQEFREQIHNLEDRLKKYEKNV 2147
Score = 32.3 bits (72), Expect = 3.0
Identities = 39/158 (24%), Positives = 68/158 (43%), Gaps = 13/158 (8%)
Query: 768 VIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASI-- 825
+++ EEE+ LQ ++ + +QK++ EE + E++ L + T I
Sbjct: 2062 ILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISD 2121
Query: 826 -----QRLIEQEEYLNVQVKELEANVLAT--APDKKKQKLLEENVSAF--KTEYDAVAEK 876
Q EQ L ++K+ E NV AT K L +VS F TE++ + +
Sbjct: 2122 SKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKV 2181
Query: 877 AGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQLD 914
E + R T+ ++ LK D+ KI ++ D
Sbjct: 2182 L--FEYMMGRETKTMAKVITTVLKFPDDQTQKILERED 2217
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 94.4 bits (233), Expect = 6e-19
Identities = 165/798 (20%), Positives = 333/798 (41%), Gaps = 86/798 (10%)
Query: 289 KMVEKEKDALEGEKNIAIEFLT--LENEIFRKKNHVCQYYIYELQKRIAEMETQK----- 341
K VE ++ L N F + L+ E +K+ + I++ Q R+ + E Q
Sbjct: 170 KDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTI 229
Query: 342 EKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQL-----DLE 396
+ + ++ + + + + + ++ + E + E++ + +L LE
Sbjct: 230 QALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLE 289
Query: 397 DVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRN---------- 446
++++R + + T A+ ++ ++K E ++ K + AK+ +E T R
Sbjct: 290 EMELRIETQKQTLNAR--DESIKKLLEMLQS-KGLSAKATEEDHERTRRLAEAEMHVHHL 346
Query: 447 NALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSEL 506
+L ++KEKE L+E M + K K + M SK + R D+ E
Sbjct: 347 ESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDL---EE 403
Query: 507 DIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLT 566
+I + + N A+S T+ +E + E + +++ K+ Q +QEL K+ EL L
Sbjct: 404 EIQMLKSNGALS--TEEREEEMKQMEVYRSHSKFMKN---KIGQVKQELSRKDTELLALQ 458
Query: 567 QEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQ------EKKSGRIPGIYGRLG 620
+ + D Q +E K SL R +L + E+K + ++
Sbjct: 459 TKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQ 518
Query: 621 DLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKR--QNIGVATFIGLDKMAVWA 678
D+ +EK A H L D +D+ + VN L++ +N+ +M+
Sbjct: 519 DMA--EEKGTQAGE--IHDLK----DMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLK 570
Query: 679 KKMTEIQ--TPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQK----D 732
+++ +Q T L L + EK R L++ D ++ + K D
Sbjct: 571 ERVKSLQADTTNTDTALTTLEEALAEKERTIE--RLKEQRDRDEREKQEEIDNYKKDLKD 628
Query: 733 RRWRVVTLQGQIIEQ----------SGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQ 782
+ +V LQG + E+ + ++ G K + +E +EE KMESQ
Sbjct: 629 LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQ 688
Query: 783 LQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKEL 842
L+ + A++ + ++ +R+ L ++ K A + RL+E + + + +
Sbjct: 689 LKKAHEAALEARASP-EMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDK 747
Query: 843 EANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQ 902
+ + K Q + V+ K + +K+ ++ E +R + + N +
Sbjct: 748 DKKIAELERQVKDQ---NKKVANLKHKEQVEKKKSAQMLEEARRREDNL----NDSSQQL 800
Query: 903 QDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRT--EKEIKDTEKEVDDLTA 960
QD L K + +++E A+ + V I TA+R + AQ+ RT EK++++ ++ +
Sbjct: 801 QDSLRKKDDRIEELEEAL-RESVQI-TAEREMVLAQEESARTNAEKQVEELLMAMEKVKQ 858
Query: 961 ELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHAL-----QKDALSIK 1015
EL+S++ K + ++ E L ++ E R L+E V++ + AL +KDA
Sbjct: 859 ELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEE--VLEMKQEALLAAISEKDANIAL 916
Query: 1016 LKLEQIDGHIAEHNSKIK 1033
L+L E + +K
Sbjct: 917 LELSSSKKKTQEEVAALK 934
Score = 75.5 bits (184), Expect = 3e-13
Identities = 72/406 (17%), Positives = 176/406 (43%), Gaps = 24/406 (5%)
Query: 227 ILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEILNEHRGEKLN 286
+L + +QI M + T+ G + L+D++ + VL +++E L E +K
Sbjct: 509 MLNKKTKQIQDMAEEKGTQ--AGEIHDLKDMLDVKE--RKVNVLQKKIENLQEQLRDKEK 564
Query: 287 RVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHE 346
++ +++ +L+ + LT E +K + + + E + + + +
Sbjct: 565 QMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKK 624
Query: 347 DTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKH 406
D K++ EK ++L ++ K + D ++ + + + + L++ Q +E+
Sbjct: 625 DLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLK 684
Query: 407 ATSKAKK-------------LEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEK 453
S+ KK + ++Q + ++ +K +K+ ++ +E EK
Sbjct: 685 MESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK 744
Query: 454 EKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMD---VAQSELDIYL 510
++KK+ E+ +K + + + K + E ++ + EAR + D + +L L
Sbjct: 745 NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSL 804
Query: 511 SRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEET 570
+ + + +L +EAL + + ER+ + E E++++E ++K+ QE
Sbjct: 805 RKKDDRIEEL---EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELE 861
Query: 571 NFKSLVHDLFQKVEEAKSSLA-MNRSRGKVLDAIIQEKKSGRIPGI 615
+ K+ + Q + E ++ L + R K L+ +++ K+ + I
Sbjct: 862 SMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAI 907
Score = 72.4 bits (176), Expect = 3e-12
Identities = 137/644 (21%), Positives = 255/644 (39%), Gaps = 123/644 (19%)
Query: 259 GCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRK 318
G L E I++L + E R E++ ++++ ++ + ++ E+ RK
Sbjct: 397 GLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIG------QVKQELSRK 450
Query: 319 KNHVC--QYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKL 376
+ Q + L + ++ + E + E +++ IL E+ A +++ E L
Sbjct: 451 DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETML 510
Query: 377 NKITKFIEEN-KEKFTQL----DLEDV-QVRE-KLKHATSKAKKLEKQLQKDKEK----- 424
NK TK I++ +EK TQ DL+D+ V+E K+ K + L++QL +DKEK
Sbjct: 511 NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQL-RDKEKQMSSL 569
Query: 425 VEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKE 484
E KS+ A + N TT AL EKE+ ++LKE D +++ +++E
Sbjct: 570 KERVKSLQADTTNTDTALTTLEEAL-AEKERTIERLKEQRD----------RDEREKQEE 618
Query: 485 LMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDI 544
+ + K + + + K+ + Q +L S L + A AS LK+
Sbjct: 619 IDNYKKDLKDLKEKVSLLQGDLS------EKEASLLDLKEHASSLASSGLKK-------- 664
Query: 545 EGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAII 604
+ +L E L++K++E K+ + +K EA L+A
Sbjct: 665 DSRLKTLEIALEQKKEECLKMESQ-----------LKKAHEA------------ALEARA 701
Query: 605 QEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNF---LKRQ 661
+ S RI + + K + L + + D ++ +K Q
Sbjct: 702 SPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQ 761
Query: 662 NIGVATFIGLDKMAVWAKKMTEI---------QTPENTPRLFDLVKVKDEKIRQAFYFAL 712
N VA K V KK ++ +++ +L D ++ KD++I
Sbjct: 762 NKKVANL--KHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI-------- 811
Query: 713 RDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEIS 772
+ L++A R + Q +V Q + R + +E
Sbjct: 812 ------EELEEALRESVQITAEREMVLAQEE----------------SARTNAEKQVEEL 849
Query: 773 EEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQE 832
+ K++ +L++ K Q+ + E + LR E R LE+ L ++
Sbjct: 850 LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLR---AERRKHLEEV------LEMKQ 900
Query: 833 EYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEK 876
E L + E +AN+ K+K EE V+A K E D + ++
Sbjct: 901 EALLAAISEKDANIALLELSSSKKKTQEE-VAALKREKDRLVQQ 943
Score = 70.9 bits (172), Expect = 8e-12
Identities = 161/844 (19%), Positives = 340/844 (40%), Gaps = 149/844 (17%)
Query: 334 IAEMETQ-KEKIHEDT---KEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEK 389
I +++TQ KE + E+ K++ K + LS+ M + K E K + + E +K
Sbjct: 151 IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI-KTFWSPELKKERALRKDEASKIT 209
Query: 390 FTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNAL 449
+ VQ + T +A + E ++Q+D ++ + S + E T N
Sbjct: 210 IWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEEN--- 266
Query: 450 EKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIY 509
Q L E E + KEL K++ E +++ + L+
Sbjct: 267 ---------------------FQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
Query: 510 LSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEE 569
+ ++ ++K A+E ER + + E + E L++KEKE L +E
Sbjct: 306 -DESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREE- 363
Query: 570 TNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKY 629
+ ++ E A S ++ K L +I E K +I + L DL +E+
Sbjct: 364 ---------MHRRFENAPDS-----AKTKALQTVI-EMKDSKISSMERGLRDL---EEEI 405
Query: 630 DVAISSCCHALDYIVVD--SIDIAQECVNFLKRQNIGVATFIGLDKMAVWAK--KMTEIQ 685
+ S+ + + + +++ + F+K + IG K + K ++ +Q
Sbjct: 406 QMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNK-------IGQVKQELSRKDTELLALQ 458
Query: 686 TP-ENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQ-KDRRWRVVTLQGQ 743
T E F K E ++++ + + A R+ + K+ T Q Q
Sbjct: 459 TKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQ 518
Query: 744 -IIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEE 802
+ E+ GT G + ++++ E +VN ++ +++N ++ ++Q L+E
Sbjct: 519 DMAEEKGTQAGEIHDLKD-------MLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 571
Query: 803 RVVKLR--------------------------------HSEREMRNTLEKFTASIQRLIE 830
RV L+ ERE + ++ + ++ L E
Sbjct: 572 RVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKE 631
Query: 831 QEEYLNVQVKELEANV---------LATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVE 881
+ L + E EA++ LA++ KK +L + + E+ K+E
Sbjct: 632 KVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRL-----KTLEIALEQKKEECLKME 686
Query: 882 AEVKRLHNTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAI-------KTADRNL 934
+++K+ H +E D++ + +++ +KAQ + K +
Sbjct: 687 SQLKKAHEAALEA--RASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEK 744
Query: 935 QKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLL 994
+ E+++KD K+V +L + + + K+A++++ E++L + ++ ++ L
Sbjct: 745 NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSL 804
Query: 995 QEL-KVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIE 1053
++ I+E E AL ++++ I + E + +A+ S K++ ++ + +E
Sbjct: 805 RKKDDRIEELEEAL-RESVQITAEREMV---LAQEESARTNAEKQVEELLM------AME 854
Query: 1054 EISVLSPEDLEAIKNPDSITNQIALLEARCH------EMKPNLGAIAEYKKKEELYLQRV 1107
++ ++LE++K S T Q +L E H E + +L + E K+E L +
Sbjct: 855 KVK----QELESMKAKLSSTQQ-SLAEKETHLTNLRAERRKHLEEVLE--MKQEALLAAI 907
Query: 1108 AELD 1111
+E D
Sbjct: 908 SEKD 911
Score = 66.6 bits (161), Expect = 1e-10
Identities = 71/299 (23%), Positives = 142/299 (47%), Gaps = 31/299 (10%)
Query: 311 LENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVK 370
LE EI R K+ E K AE++ ++ E KE+ + N ++ + VK
Sbjct: 712 LEREITRYKD--------ESSKAQAEVD----RLLEILKEVENEKNDKDKKIAELERQVK 759
Query: 371 DTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKS 430
D KK+ + + K+K Q+ LE+ + RE + +++L+ L+K +++EE +
Sbjct: 760 DQNKKVANLKHKEQVEKKKSAQM-LEEARRRED--NLNDSSQQLQDSLRKKDDRIEELEE 816
Query: 431 IPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSK 490
+S I E E + EK+++E++ ++++ +++E ES + +L +
Sbjct: 817 ALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEK----VKQELESMKAKLSSTQQ 872
Query: 491 SVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQ 550
S+ E + + ++E R L +EAL+AA K+ A+ ++ +
Sbjct: 873 SLAEKETHLTNLRAE------RRKHLEEVLEMKQEALLAAISE-KDANIALLELSSSKKK 925
Query: 551 TEQEL----KEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQ 605
T++E+ +EK++ +Q+L Q+ N L+ D ++ + KSS + + D IIQ
Sbjct: 926 TQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED-DHFKSSHSNQTNHKPSPDQIIQ 983
Score = 33.9 bits (76), Expect = 1.0
Identities = 37/175 (21%), Positives = 70/175 (40%), Gaps = 19/175 (10%)
Query: 263 LNEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHV 322
L E +++ R +L + + N K VE E +A+E + E E + K
Sbjct: 818 LRESVQITAEREMVLAQEESARTNAEKQVE--------ELLMAMEKVKQELESMKAK--- 866
Query: 323 CQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKF 382
+ Q+ +AE ET + + ++ E+ + E KD L +++
Sbjct: 867 ----LSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSS 922
Query: 383 IEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNN 437
++ +E+ L E ++ ++LK T K L D + + FKS + N
Sbjct: 923 KKKTQEEVAALKREKDRLVQQLKQQTQNRMK----LMADNYEDDHFKSSHSNQTN 973
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 94.0 bits (232), Expect = 8e-19
Identities = 195/983 (19%), Positives = 415/983 (42%), Gaps = 118/983 (12%)
Query: 207 KDVGNLLRSHGIDLDH-NRFLILQGEVEQIAMM-KPKGQTEHDEGMLEYLEDIIGCGRLN 264
++V +L H ++ N + E E++ +M + +G E E + + ++ I LN
Sbjct: 424 REVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAI----LN 479
Query: 265 EPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLE-NEIFRKKNHVC 323
+ L +EIL GE ++ +E ++++ ++ + L + F +K+ +
Sbjct: 480 --YESLREIMEILQTELGESAGKIS---QEFESMKQQQASDVHELQQKLRTAFTEKDALL 534
Query: 324 QYYIYELQKRIAEMETQKEKIHE---DTKEINEKSNILSNEMKAKNKDVKDTEKKLNKIT 380
+ + LQ ++ +Q+E + E K + EK+ + + ++ +K+ E K+N +T
Sbjct: 535 ET-VNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLT 593
Query: 381 KFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIIN 440
EE + +L E++ + K ++ E+ + + +KVE+ ++ +N
Sbjct: 594 ---EEKDDFINKLK----NSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVN 646
Query: 441 ETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMD 500
E T KEK++ ++KL+++M +K L ++KE E+ + N+ S+
Sbjct: 647 ELTGGLEETLKEKDQNDQKLEKLMVQMKV----LSEDKEVLSAEVKSLYEENNKLSSEKK 702
Query: 501 VAQSELDIYLSRHNTA-----VSQLTKAKEALIAASETLKE-------RKAAIR-DIEGK 547
+L+++LS+ ++QL K + ++ + L + +K ++ + G
Sbjct: 703 QLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGF 762
Query: 548 LPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEK 607
L + E+ E +E ++ N V + K+ E K +LA R KVL+ EK
Sbjct: 763 LKEMGSEVSEDSEE-----KDVVNVLQAVGESLAKINEEKCNLAFQRDE-KVLEL---EK 813
Query: 608 KSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVAT 667
++ + E+ V C L ++ D QE V K +
Sbjct: 814 -------------EIKCLQEESVVQ----CEELKSLL---RDYEQEKVLLRKELEEIQSE 853
Query: 668 FIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVA--DNLDQAT 725
L + K E EN L + +V + + + +NL
Sbjct: 854 KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913
Query: 726 RVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMK-GRMGSSLVIEI--SEEEVNKM--- 779
+DRR ++ L+ + + S V + +L E EE++NK+
Sbjct: 914 EQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLV 973
Query: 780 ----ESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYL 835
+ +L + K+ ++E+ L +L S R++ E + + +Q E L
Sbjct: 974 AVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQL 1033
Query: 836 NVQVKELEANVLATAPDKKKQ-KLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEI 894
+V+ KE N D +Q + ++ + + + +++ K L I+E+
Sbjct: 1034 DVE-KERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEV 1092
Query: 895 NNHKLKAQQD-KLDKINKQ--LDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDT 951
K ++ + +K+ K+ + E A+ + + ++ LQK + + +T +E++
Sbjct: 1093 QRAKAMVDKELEAEKLQKEQKIKEHATTVNE----LEELQVQLQKEKKQLQKTMQELELV 1148
Query: 952 EKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDA 1011
+K+ T L ++E A+ + + L + +L QE+K+ ++ + LQ++
Sbjct: 1149 KKDAQQTT--LMNME--IADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEI 1204
Query: 1012 LSIKLKLEQIDGHIAEHNSKIKY----WHKEISKISLHPIEDNPIEEISVLSPEDLEAIK 1067
S++ ++Q + E N+KIK KE++ S D+ I + S+ +LEA +
Sbjct: 1205 TSLQSSVQQYE----EKNTKIKQLLVKTKKELAD-SKQAETDHLILQASLKG--ELEASQ 1257
Query: 1068 NPDSITN-QIALLEARCHEMKPNLGAIAE-YKKKEELYLQRV-----------AELDKIT 1114
+ Q+A + + H++ +L AE +++ Y QRV AE +T
Sbjct: 1258 QQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVT 1317
Query: 1115 YERDSFRQAYEDLRKQRLNEFMA 1137
E +S++ ++ KQ+ N+ M+
Sbjct: 1318 SEFESYKVRVHNVLKQQKNKSMS 1340
Score = 87.4 bits (215), Expect = 8e-17
Identities = 155/872 (17%), Positives = 370/872 (42%), Gaps = 106/872 (12%)
Query: 264 NEPIKVLCRRVEILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIF--RKKNH 321
++ ++ L ++++L+E + VK + +E + L EK + L+ + E+F +K++
Sbjct: 663 DQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEK----KQLSRDLEVFLSQKEDV 718
Query: 322 VCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITK 381
+ + +I +L+K++ M +++ +++ +L NE K L ++
Sbjct: 719 ILKEHITQLEKKLQLMVEEQDNLNK----------LLENEQVQKLFVKTQLYGFLKEMGS 768
Query: 382 FIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINE 441
+ E+ E+ +++ V E L A +K Q+D++ +E K I + +
Sbjct: 769 EVSEDSEEKDVVNVLQA-VGESL--AKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQ 825
Query: 442 TTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKE----KESREK------ELMGFSKS 491
+ L ++ E+E+ L++ ++ ++ E + LQ + K + EK L+ +
Sbjct: 826 CEELKSLL-RDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEE 884
Query: 492 VNEARSKMDVAQSELDIYLSRHNTAV------------SQLTKAKEALIAASETLKERKA 539
V++ SK ++ + ++ H ++L K++L + + +
Sbjct: 885 VSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLS 944
Query: 540 AIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKV 599
+++++E K+ E+E KEKE+++ K+ K + ++ + K L RS
Sbjct: 945 SVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQ 1004
Query: 600 LDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVA---ISSCCHALDYIVVDSIDIAQECVN 656
L A +++ G L + E+ DV ++ H ++ + + +C
Sbjct: 1005 LSASMRDLIQGA-ESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCET 1063
Query: 657 FLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTL 716
+A L A K+ E+Q E R +V + E + +++
Sbjct: 1064 INSDNEDLLARIETLQSNA----KLLEVQILE-VQRAKAMVDKELEAEKLQKEQKIKEHA 1118
Query: 717 VADNLDQATRVAYQKDRRWRVVTLQG-QIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEE 775
N + +V QK+++ T+Q +++++ T + + +EI++ E
Sbjct: 1119 TTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQT------------TLMNMEIADYE 1166
Query: 776 VNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYL 835
+L + + + + K++ E+ +K++ ++E TL++ S+Q ++Q E
Sbjct: 1167 ------RLMKELNQKLTNKNNKIEDLEQEIKIQKQKQE---TLQEEITSLQSSVQQYEEK 1217
Query: 836 NVQVKELEANVLATAPDKKK--------QKLLEENVSAFKTEYDAVAEKAGKVEAEVKRL 887
N ++K+L D K+ Q L+ + A + + + + ++ +E ++
Sbjct: 1218 NTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKI 1277
Query: 888 H---NTIVEINNHKLKAQQDKLDKINKQLDECASA------ITKAQVAIKTADRNLQKAQ 938
H T E + L A Q ++ + +EC +A +T + K N+ K Q
Sbjct: 1278 HEHLKTSAEQHQRTLSAYQQRVTALQ---EECRAAKAEQATVTSEFESYKVRVHNVLKQQ 1334
Query: 939 DSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELK 998
+ ++ E + ++E + L + L+ K + N L +Q EH LL
Sbjct: 1335 KNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLL---- 1390
Query: 999 VIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKE-ISKISL--HPIEDNPIEEI 1055
E + + ++ +S + +L + I N +K H + +S+++ + ++ +++
Sbjct: 1391 ---ERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQV 1447
Query: 1056 SVLSPEDLEAIKNPDSITNQIALLEARCHEMK 1087
L E + + +++ Q++ +EA+ ++K
Sbjct: 1448 RHLQEEHRKTV---ETLQQQLSKMEAQLFQLK 1476
Score = 77.4 bits (189), Expect = 8e-14
Identities = 193/921 (20%), Positives = 376/921 (40%), Gaps = 185/921 (20%)
Query: 287 RVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIH- 345
++ ++K+ DA EK + L+N I H Q I LQ+ + +++ IH
Sbjct: 197 QILYLQKQLDATTDEKKETVT--QLQNIIEANSQHY-QKNINSLQEELLQLKA----IHQ 249
Query: 346 EDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQ------ 399
E+ KE+ + + E +A+ + + ++ L K + E+N +K + +LE+++
Sbjct: 250 EEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNA 309
Query: 400 --------------------VREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNII 439
V EK+KH K+LE Q K++V ++ K +
Sbjct: 310 NQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLK---LE 366
Query: 440 NETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKM 499
+ + E+E E K+ E++ L +E QG EK + EL G +K + +
Sbjct: 367 MDAQHIKDEFFHEREDLEFKINELL--LAKEEQGCVIEK--LKSELAGLNK---QFCYTV 419
Query: 500 DVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKE 559
+ E+ +H +S+L E ++ SE KE+ + +I+G Q E +EK+
Sbjct: 420 EQHNREVQSLKEQHQKEISEL---NETFLSDSE--KEKLTLMFEIQGLKEQCENLQQEKQ 474
Query: 560 KELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRL 619
+ + N++SL +++ E + + S GK+ K+ +
Sbjct: 475 EAI-------LNYESL-----REIMEILQT-ELGESAGKISQEFESMKQQ--------QA 513
Query: 620 GDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAK 679
D+ + +K A + D E VN L+ +N +K+
Sbjct: 514 SDVHELQQKLRTAFT------------EKDALLETVNRLQGEN---------EKL----- 547
Query: 680 KMTEIQTPENTPRLFDLVKVKDEKIRQAFYFAL--RDTLVADNLDQATRVAYQKDRRWRV 737
+ E P L + +K EK + +L RDT++ + + + +KD
Sbjct: 548 ----LSQQELVPELENTIKNLQEK-NGVYLLSLSQRDTMLKELEGKINSLTEEKD----- 597
Query: 738 VTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQK 797
++ M K + L++E+ + K+E +Q +S+ ++ E
Sbjct: 598 -DFINKLKNSHEEMDNFHKKCER---EERLILELGK----KVEQTIQYNSELEQKVNELT 649
Query: 798 VQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKEL--EANVLATAPDKKK 855
LEE + + ++++ LEK ++ L E +E L+ +VK L E N L++ +
Sbjct: 650 GGLEETLKEKDQNDQK----LEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSS-----E 700
Query: 856 QKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKLKAQQDKLDKINKQ--- 912
+K L ++ F ++ + V K + E K+L + E +N + +++ K+ +
Sbjct: 701 KKQLSRDLEVFLSQKEDVILKEHITQLE-KKLQLMVEEQDNLNKLLENEQVQKLFVKTQL 759
Query: 913 ---LDECASAITKAQVAIKTADRNLQKAQDSVLRTEKE----IKDTEKEVDDLTAELKSL 965
L E S +++ K LQ +S+ + +E +++V +L E+K L
Sbjct: 760 YGFLKEMGSEVSEDSEE-KDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCL 818
Query: 966 EDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIK---------- 1015
++ E V + L + ++E L +EL+ IQ + ALQ D L +K
Sbjct: 819 QE---ESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLEN 875
Query: 1016 ----LKLEQIDGHIAE---HNSKIKYWHKEISKI--------------SLHPIEDNPIEE 1054
+++E++ ++ HN K K + KE + L ++D+ +
Sbjct: 876 QNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKS 935
Query: 1055 ISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAI--AEYKKKEELYLQR------ 1106
SV + + L ++K + +I LE C E + + I K K+EL R
Sbjct: 936 PSVKN-DPLSSVK---ELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTV 991
Query: 1107 VAELDKITYERDSFRQAYEDL 1127
EL+ + E+D + DL
Sbjct: 992 KEELESLRSEKDQLSASMRDL 1012
Score = 55.1 bits (131), Expect = 4e-07
Identities = 72/372 (19%), Positives = 162/372 (43%), Gaps = 42/372 (11%)
Query: 234 QIAMMKPKGQTEHDEGMLEYLE-DIIGCGRLNEPIKVLCRRVEILNEHRGEKLNRVKMVE 292
Q+ + K K Q + LE ++ D +N I R ++ LN+ K N+++ +E
Sbjct: 1128 QVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE 1187
Query: 293 KEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEIN 352
+E + ++ TL+ EI ++ V QY E +I ++ + +K D+K+
Sbjct: 1188 QEIKIQKQKQE------TLQEEITSLQSSVQQYE--EKNTKIKQLLVKTKKELADSKQAE 1239
Query: 353 EKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAK 412
IL +K + L + +E K + ++ E ++ E LK + + +
Sbjct: 1240 TDHLILQASLKGE----------LEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQ 1289
Query: 413 K-LEKQLQKDKEKVEEFKSIPAKSNNIINETTTR----NNALEKEKEKEEKKLKEVMDSL 467
+ L Q+ EE ++ A+ + +E + +N L+++K K +
Sbjct: 1290 RTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQA------- 1342
Query: 468 KQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEAL 527
ET+G ++E+E E + + ++++ + + SEL S H+T + + K +
Sbjct: 1343 --ETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQET 1400
Query: 528 IAASETLKERKAAIRD----IEGKLPQTEQELKEKEKELQKLTQEET-----NFKSLVHD 578
++ L+E+ +I+ ++ + QT +L + + L+ +++ + V
Sbjct: 1401 VSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVET 1460
Query: 579 LFQKVEEAKSSL 590
L Q++ + ++ L
Sbjct: 1461 LQQQLSKMEAQL 1472
Score = 54.7 bits (130), Expect = 6e-07
Identities = 156/798 (19%), Positives = 319/798 (39%), Gaps = 139/798 (17%)
Query: 387 KEKFTQLDLED-VQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTR 445
K K L ED ++ +K KAK +L+K+ E++ K + + +II T R
Sbjct: 19 KSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRS-KPVTEGTGDIIKALTER 77
Query: 446 NNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSE 505
+AL EK + E++ SLK+E +++E V ++ +KM A E
Sbjct: 78 LDALLLEKAETEQQCL----SLKKENIKMKQE--------------VEDSVTKMGDAHKE 119
Query: 506 LDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKL 565
L+ H V ++ K L+A E KA ++ + T+ EL E +L+
Sbjct: 120 LE---QSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSE---QLKFQ 173
Query: 566 TQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAI 625
E N K L ++ +K+ + K LDA EKK + L I
Sbjct: 174 NNSEDNVKKLQEEI-EKIRPGFEEQILYLQ--KQLDATTDEKKE--------TVTQLQNI 222
Query: 626 DEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQ 685
E ++L ++ I QE V L Q A + K+ E++
Sbjct: 223 IEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASA-----KEHEAEINKLNELK 277
Query: 686 TPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQII 745
EN L + ++ I++ + L +NL +AT A Q ++ ++ + +
Sbjct: 278 --EN---LVKQCEASEKNIQKKYECEL------ENLRKATSNANQDNQICSILLQENTFV 326
Query: 746 EQ-SGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAM-QIQEQKVQLEER 803
EQ +K +++ +N ++ +L+ D++ + ++ LE +
Sbjct: 327 EQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFK 386
Query: 804 VVKLRHSEREMRNTLEKFTASIQRLIEQ---------------EEYLNVQVKELEANVLA 848
+ +L ++ E +EK + + L +Q +E ++ EL L+
Sbjct: 387 INELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLS 446
Query: 849 TAPDKKKQKLLE--------ENVSAFKTE----YDA-----------VAEKAGKVEAEVK 885
+ +K + E EN+ K E Y++ + E AGK+ E +
Sbjct: 447 DSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFE 506
Query: 886 RLH----NTIVEINNHKLKAQQDK---LDKINKQLDECASAITKAQVA--IKTADRNLQK 936
+ + + E+ A +K L+ +N+ E +++ ++ ++ +NLQ+
Sbjct: 507 SMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQE 566
Query: 937 ----------AQDSVLR-TEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPE 985
+D++L+ E +I +E DD +LK+ ++ K E + E
Sbjct: 567 KNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILE 626
Query: 986 IQKEHRNLLQ------------------ELKVIQENEHALQKDALSIKLKLEQIDGHIAE 1027
+ K+ +Q LK +N+ L+K L +++K+ D +
Sbjct: 627 LGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEK--LMVQMKVLSEDKEVL- 683
Query: 1028 HNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMK 1087
++++K ++E +K+S + + E+ + ED+ ++ + ++ L+ E +
Sbjct: 684 -SAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMV----EEQ 738
Query: 1088 PNLGAIAEYKKKEELYLQ 1105
NL + E ++ ++L+++
Sbjct: 739 DNLNKLLENEQVQKLFVK 756
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 93.6 bits (231), Expect = 1e-18
Identities = 179/981 (18%), Positives = 392/981 (39%), Gaps = 180/981 (18%)
Query: 275 EILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFL------TLENEIFRKKNHVCQYYIY 328
++L E + KMV +++ +L+ K I+ T + + ++ + Y
Sbjct: 305 KVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAE 364
Query: 329 ELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKE 388
EL K + K+K+ E +++ + IL + K+ K +++ +E KE
Sbjct: 365 ELSKAFQQY---KKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKE 421
Query: 389 KFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNA 448
K QL E+ +EKL+ K ++ QL + ++ + + +S + I+ + + N
Sbjct: 422 KLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSLMNE 481
Query: 449 LEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREK---------ELMGFSKSVNE----- 494
+E + E +D +QE + + E S EK EL GF +++
Sbjct: 482 -NRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSS 540
Query: 495 -------------------ARSKMDVAQSELDIYLSRHNTAVSQLTKA--------KEAL 527
+ ++ +A E +I N +QL+++ + +
Sbjct: 541 FSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESSK 600
Query: 528 IAASETLKERKAAIRDIEGKLPQTEQEL-KEKEKELQKLTQEETNFKSLVHDLFQKVEEA 586
+++ ET + + E Q + + K+ EKE Q+L ++ + + + +
Sbjct: 601 LSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDL 660
Query: 587 KSSLAMNRSRGKVLDAIIQEKKSGRI---PGIYGRLGDLGAIDEKYDVAISSCCHALDYI 643
K ++A S+ +++ + EK S + + L ++++ + I A I
Sbjct: 661 KVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIV----AYSSI 716
Query: 644 VVDSIDIAQE----------------------CVNFLKRQNIGVATFIGLDKMAVWAKKM 681
+ ++ QE C+ F K + I + ++K +
Sbjct: 717 AAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQ 776
Query: 682 TEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQ 741
E + + + + ++ + I + + D L+ ++ + + +KD + LQ
Sbjct: 777 LEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALK--ALQ 834
Query: 742 GQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVN--KMESQLQNDS------KKAMQI 793
Q+ E++ + S + + LV+ +++ E N K E QL+ S +K ++I
Sbjct: 835 NQVSEETIKVRQLDSALEICK--EELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKI 892
Query: 794 QEQKVQ-LEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQVKELEANV------ 846
+ +Q E+ V L+H+ ++ + L++ T L + + L QV +LE +
Sbjct: 893 KNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRES 952
Query: 847 --------------LATAPDKKKQKLLEENVSA--FKTEYDAVAEKAGKVEAEV------ 884
A D K+QK++E +A K E D E+ K+E E+
Sbjct: 953 SAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRD 1012
Query: 885 ---KRLHNTIVEINNHKLKAQQDKLDKINKQLD--------ECASAITKAQV-------- 925
K +H + +++ + K + +K K+L+ E A+ K +V
Sbjct: 1013 GENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNA 1072
Query: 926 --AIKTADRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELK----SLEDKAAEVVKNTNAA 979
+K+ R LQ+ +D + + + +++ + DLTAEL+ +EDK E+++ A
Sbjct: 1073 HGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQAL 1132
Query: 980 EESLPEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEI 1039
+E E+++ + I+E+ +++ K+ +++G + + ++K +K+I
Sbjct: 1133 KERNWELKQRAAQVTHLDMTIREHRGEMEQ-------KIIKLEGTLEKSELELKECNKQI 1185
Query: 1040 SKISLHPIEDNPIEEISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKK 1099
++ D + N L + M N I++ KK+
Sbjct: 1186 ESLN--------------------------DKLQNAKEQLREKEFIMLQNEQEISQLKKE 1219
Query: 1100 EELYLQRVAELDKITYERDSF 1120
E QR+ E++ + E++ +
Sbjct: 1220 IERTQQRMKEMESVMKEQEQY 1240
Score = 89.4 bits (220), Expect = 2e-17
Identities = 198/1019 (19%), Positives = 408/1019 (40%), Gaps = 213/1019 (20%)
Query: 268 KVLCRRVEILNEHRGEKLN------RVKMVEKEKDALEGEKNIA---IEFLTLENEIFRK 318
++L + ++NE+R K+ R+ + ++E ++ E I L L+ E+F
Sbjct: 470 EILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGF 529
Query: 319 KNHVCQYY---------------------IYELQKRIAEMETQKEKIH------------ 345
K+++ +Y I EL+ ++A E + +K+H
Sbjct: 530 KSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSL 589
Query: 346 ---EDTKEINEKSNILSNEMKAKNKDV-------------KDTEKKLNKITKFIEENKEK 389
D++E ++ S++ + +K V K EK+ ++ IEE + K
Sbjct: 590 ITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTK 649
Query: 390 FTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTR-NNA 448
Q++ E+ ++ + H TS+ + ++++L + + S+ + +E T + +
Sbjct: 650 LIQIEAENSDLKVNMAHRTSQFQLIQEELLEKA----------SNSSKLESEMTKKCSQL 699
Query: 449 LEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVA-QSELD 507
L EK+ EEK + S+ + L++E + +++ ++N K+ +A +
Sbjct: 700 LTLEKQLEEKIV--AYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKK 757
Query: 508 IYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQ 567
I+L +H Q+ + + L + KE+ E + +Q++ K+ L+ L +
Sbjct: 758 IHLEQHKEMEKQIERLEAQLEKKDQQFKEQ-------EKTMSMLQQDIICKQHHLESLDR 810
Query: 568 EETNFKSLVHDLFQKVEEAKSSLAMNRSRGKV----LDAIIQEKKSGRIPGIYGRLGDLG 623
T K + K +EA +L S + LD+ ++ K + L L
Sbjct: 811 LLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVL----HLNQLE 866
Query: 624 AIDEKYDVAISSCCHALDYIVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTE 683
EK++ + + Y + + I + QN+ + + + + + +
Sbjct: 867 GNKEKFEKQLKKKSEEV-YCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRN 925
Query: 684 IQTPENTPRLFDLV-KVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQG 742
+ + +L V K++ E +Q A + + + + A A K ++
Sbjct: 926 GELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQK-------- 977
Query: 743 QIIEQSGTMTGGGSKVMKGRMGSSLVIEISE--EEVNKMESQL----QNDSKKAMQIQE- 795
+IE +GT + IE+ + EE++KME ++ ++ KAM + +
Sbjct: 978 -VIELTGT-------------ARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQL 1023
Query: 796 ------QKVQLEER------VVKLRHS---------------EREMRNTLEKFTASIQRL 828
K +LE++ + KL+HS E E++N + +++++L
Sbjct: 1024 DMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQL 1083
Query: 829 IE------------QEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEK 876
E +E+Y ++ E + KKQ+LLE + A K + ++
Sbjct: 1084 QELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMD-QALKERNWELKQR 1142
Query: 877 AGKVEAEVKRLHNTIVEINNH---KLKAQQDKLDKINKQLDECASAITKAQVAIKTADRN 933
A A+V L TI E K+ + L+K +L EC I ++ A
Sbjct: 1143 A----AQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQ 1198
Query: 934 LQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNL 993
L++ + +L+ E+EI +KE++ +K +E E E+ + KE +L
Sbjct: 1199 LREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKE-------QEQYIATQYKEAIDL 1251
Query: 994 LQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIE 1053
QEL++ +E +++ +AE + +EI ++S + +E
Sbjct: 1252 GQELRLTRE--------------QVQNSHTELAEARHQQVQAQREIERLS------SELE 1291
Query: 1054 EISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKI 1113
++ LS E +A + + LGA + E +Q AE+ K+
Sbjct: 1292 DMKQLSKEK-----------------DAHGNHLAEELGASKVREAHLEARMQ--AEIKKL 1332
Query: 1114 TYERDSFRQAYEDLRKQRLNEFMAGFYIITNKLKENYQMLTLGGD-AELELVDSLDPFS 1171
+ E +S ++AY + E A + I + K + Q L + A+LEL ++ D S
Sbjct: 1333 SAEVESLKEAYH-MEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVS 1390
Score = 86.7 bits (213), Expect = 1e-16
Identities = 132/685 (19%), Positives = 292/685 (42%), Gaps = 92/685 (13%)
Query: 218 IDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRVEIL 277
I+ +H + + + ++I + + K + E + LE + E + ++ I
Sbjct: 741 INTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIIC 800
Query: 278 NEHRGEKLNRVKMVEKEKDALEG-EKNIAIEFLTLENEI------FRKKNHVCQYYIYEL 330
+H E L+R+ K + E +K+ A++ L+N++ R+ + + EL
Sbjct: 801 KQHHLESLDRLLTESKGEMKKENMKKDEALK--ALQNQVSEETIKVRQLDSALEICKEEL 858
Query: 331 QKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKLNKITKFIEENKEKF 390
+ ++E KEK + K+ +E+ L E+K KN +++T ++ + +++ ++
Sbjct: 859 VLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQML 918
Query: 391 TQLDLEDVQVREKLKHATSKAKKLEKQLQKDKE-KVEEFKSIPAKSNNIINET------- 442
Q + + ++ + + KLE++LQK +E E+ + + K + +E
Sbjct: 919 QQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKV 978
Query: 443 -----TTRNNALEKEKEKEE--KKLKEVM----------------DSLKQETQGLQKEKE 479
T R +E ++ KEE K KE+M D + +T+ ++K
Sbjct: 979 IELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKT 1038
Query: 480 SREKELMGFSKS----VNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLK 535
+ KEL S + EA K +V ++EL + + QL + ++ L A +L+
Sbjct: 1039 NAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLE 1098
Query: 536 ERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRS 595
E+ I+D+ +L + + E+++K++EL ++ Q ++E L +
Sbjct: 1099 EKYTTIKDLTAELRECKMEIEDKKQELLEMD--------------QALKERNWELKQRAA 1144
Query: 596 RGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECV 655
+ LD I+E + I G L EK ++ + C ++ + D + A+E
Sbjct: 1145 QVTHLDMTIREHRGEMEQKIIKLEGTL----EKSELELKECNKQIESL-NDKLQNAKE-- 1197
Query: 656 NFLKRQNIGVATFIGLDKMAVWAKKMTEIQ-TPENTPRLFDLVKVKDEKIRQAFYFALRD 714
+ FI L ++ EI+ T + + ++K +++ I + A+
Sbjct: 1198 ------QLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAI-- 1249
Query: 715 TLVADNLDQATRVAYQK---------DRRWRVVTLQGQIIEQSGTMTGGGS-KVMKGRMG 764
+L Q R+ ++ + R + V Q +I S + K G
Sbjct: 1250 -----DLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAHG 1304
Query: 765 SSLVIEISEEEVNK--MESQLQNDSKK-AMQIQEQKVQLEERVVKLRHSEREMRNTLEKF 821
+ L E+ +V + +E+++Q + KK + +++ K ++ + + + + + +
Sbjct: 1305 NHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQ 1364
Query: 822 TASIQRLIEQEEYLNVQVKELEANV 846
+S+Q+L EQ E ++++E + V
Sbjct: 1365 KSSVQQLNEQLEKAKLELEEAQDTV 1389
Score = 84.7 bits (208), Expect = 5e-16
Identities = 153/875 (17%), Positives = 342/875 (39%), Gaps = 130/875 (14%)
Query: 309 LTLENEIFRKKNHVCQYYIYELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKD 368
L +N K + + + + +++ +E+ +++ + E+ L E+ A++K
Sbjct: 248 LVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQA-ASVPILEEQIINLEAEVSAQDKV 306
Query: 369 VKDTEKKLNKITKFIEENKEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEF 428
+++ E KL + K + E ++ + E ++++ L T + K+ E+Q + EE
Sbjct: 307 LREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEEL 366
Query: 429 KSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGF 488
+ A ++ K+K +KL++V Q E+E E+ L
Sbjct: 367 -----------------SKAFQQYKKKVAEKLEKV-----------QAEEEILERNLTNC 398
Query: 489 SKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKL 548
K + + + +SEL+I + + KE L + E A + + +
Sbjct: 399 EKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSI 458
Query: 549 PQTEQELKEKEKELQ---KLTQEETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQ 605
+ E EL+ K++ L+ L E K V ++++ + + +R + L+ II
Sbjct: 459 LKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIIS 518
Query: 606 EKKSGR-IPGIYGRLG--DLGAIDEKYDVAISSCCHALDYIV------------------ 644
+ R + G L + + K D I CC A ++
Sbjct: 519 QLPLKRELFGFKSYLSKYQMSSFSNKEDRCI-GCCEANKLVISELRIKLAIKEAEIQKLH 577
Query: 645 --VDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDE 702
+ + ++Q + Q + + + + + ++ E +N + + E
Sbjct: 578 ANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQ----HTMNKQYE 633
Query: 703 KIRQAFYFALRD------TLVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGS 756
K RQ + + + A+N D +A++ T Q Q+I++ S
Sbjct: 634 KERQRLVTGIEELRTKLIQIEAENSDLKVNMAHR--------TSQFQLIQEELLEKASNS 685
Query: 757 KVMKGRMGSSLVIEISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRN 816
++ M ++ E+ ++E ++ S A + E + +L E+ K+R E +
Sbjct: 686 SKLESEMTKKCSQLLTLEK--QLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINT 743
Query: 817 TLEKFTASIQRL----IEQEEYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDA 872
EK + ++ +EQ + + Q++ LEA + +KK Q+ E+ + + D
Sbjct: 744 EHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQL-----EKKDQQFKEQEKTMSMLQQDI 798
Query: 873 V-------------AEKAGKVEAE-------VKRLHNTI-------------VEINNHKL 899
+ E G+++ E +K L N + +EI +L
Sbjct: 799 ICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEEL 858
Query: 900 KAQQDKL----DKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTEKEV 955
++L +K KQL + + + Q +K + +LQ+ + + + ++ ++ +
Sbjct: 859 VLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQML 918
Query: 956 DDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQELKVIQENEHALQKDALSIK 1015
T LED ++ K + E+ E+QK+ + ++L+ ++E + +A +
Sbjct: 919 QQETIRNGELEDTQTKLEKQVSKLEQ---ELQKQRESSAEKLRKMEEKCESAAHEADLKR 975
Query: 1016 LKLEQIDGHIAEHNSKIKYWHKEISKISLHPIEDNPIEEISVLSPEDLEAIKNP-----D 1070
K+ ++ G + ++ + +E+SK+ + E + L+ I + +
Sbjct: 976 QKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELE 1035
Query: 1071 SITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQ 1105
TN + LE H + L + ++ E LQ
Sbjct: 1036 KKTNAVKELEKLQHSTETELTEALQKREVLETELQ 1070
Score = 59.3 bits (142), Expect = 2e-08
Identities = 89/428 (20%), Positives = 188/428 (43%), Gaps = 65/428 (15%)
Query: 215 SHGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEYLEDIIGCGRLNEPIKVLCRRV 274
+H DL + + L G Q+ + ++ E + + ++I+ R E + ++
Sbjct: 968 AHEADLKRQKVIELTGTARQVKIE----MDQYKEELSKMEKEIMHLKRDGENKAMHLSQL 1023
Query: 275 E-ILNEHRGE---KLNRVKMVEKEKDALEGEKNIAIEFL-TLENEIFRKKNHVCQYYIYE 329
+ IL++ + E K N VK +EK + + E E A++ LE E+ E
Sbjct: 1024 DMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHG--------E 1075
Query: 330 LQKRIAEMETQKEKIHEDTKEINEKSNILSN---EMKAKNKDVKDTEKKLNKITKFIEEN 386
L+ + +++ ++ + + + EK + + E++ +++D +++L ++ + ++E
Sbjct: 1076 LKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKER 1135
Query: 387 ----KEKFTQLDLEDVQVREKLKHATSKAKKLEKQLQKD----KEKVEEFKSIPAKSNN- 437
K++ Q+ D+ +RE K KLE L+K KE ++ +S+ K N
Sbjct: 1136 NWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNA 1195
Query: 438 ---------IINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQ----------GLQKEK 478
I+ + + L+KE E+ ++++KE+ +K++ Q L +E
Sbjct: 1196 KEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQEL 1255
Query: 479 ESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEA-------LIAAS 531
+++ + EAR + AQ E++ LS + QL+K K+A + AS
Sbjct: 1256 RLTREQVQNSHTELAEARHQQVQAQREIE-RLSSELEDMKQLSKEKDAHGNHLAEELGAS 1314
Query: 532 ETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNF---------KSLVHDLFQK 582
+ + A E K E E ++ ++ ++ +E + KS V L ++
Sbjct: 1315 KVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQ 1374
Query: 583 VEEAKSSL 590
+E+AK L
Sbjct: 1375 LEKAKLEL 1382
Score = 51.6 bits (122), Expect = 5e-06
Identities = 127/650 (19%), Positives = 259/650 (39%), Gaps = 112/650 (17%)
Query: 453 KEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSE---LDIY 509
K+ EE+ L + SL+ E + + +S +EL S S N + + ++SE LD+
Sbjct: 129 KDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAP-NPSRSEKLILDVQ 187
Query: 510 LSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEE 569
S H ++ I+ S T ++K + P +QE+K ++L KL Q+
Sbjct: 188 PS-HPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAP-VDQEIKSLREKLNKLRQQN 245
Query: 570 TNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKY 629
+ H L K E L +R++ +L++ Q+ S +P + ++ +L A
Sbjct: 246 ACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAAS--VPILEEQIINLEAEVSAQ 303
Query: 630 DVAISSCCHALDY---IVVDSIDIAQECVNFLKRQNIGVATFIGLDKMAVWAKKMTEIQT 686
D + + L+ +V++ QE + + + K A ++ +
Sbjct: 304 DKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAE-RQRNEALYN 362
Query: 687 PENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKDRRWRVVTLQGQIIE 746
E + F K K VA+ L++ V + +I+E
Sbjct: 363 AEELSKAFQQYKKK----------------VAEKLEK--------------VQAEEEILE 392
Query: 747 QSGTMTGGGSKVMKGRMG-SSLVIEISEEEVNKMESQLQNDSKK----AMQIQEQKVQLE 801
++ T +K ++ R G +EI +E++ +++ + N +K A++ E QL
Sbjct: 393 RNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLT 452
Query: 802 ERVVKLRHSEREMRNTLE----KFTASIQ------RLIEQEEYLNVQVKELEAN------ 845
E + E E+ N E KF+ + R+ Q E L++ +E+E++
Sbjct: 453 ESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRS 512
Query: 846 ---VLATAPDKK-----KQKLLEENVSAFKTEYD-----------AVAE---KAGKVEAE 883
+++ P K+ K L + +S+F + D ++E K EAE
Sbjct: 513 LEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAE 572
Query: 884 VKRLHNTIV--EINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRN-------- 933
+++LH + +++ + + L+ + QVA D+N
Sbjct: 573 IQKLHANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQY 632
Query: 934 ----------LQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESL 983
+++ + +++ E E D + + T++ + ++++ E N++ E
Sbjct: 633 EKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLES-- 690
Query: 984 PEIQKEHRNLLQELKVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIK 1033
E+ K+ LL K ++E A SI K +++ + E N KI+
Sbjct: 691 -EMTKKCSQLLTLEKQLEEKIVAYS----SIAAKNAELEQELMEKNEKIR 735
Score = 34.7 bits (78), Expect = 0.61
Identities = 65/326 (19%), Positives = 125/326 (38%), Gaps = 45/326 (13%)
Query: 771 ISEEEVNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIE 830
+ +++ +MES + K ++ L V LRH + +L+ + +
Sbjct: 111 LPSDDLGEMESSSSDYYNK----DNEEESLLANVASLRHELKITEWSLQSLGEELSSVSP 166
Query: 831 QE-----------EYLNVQVKELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGK 879
E E L + V+ +L +P + K+ + K D + +
Sbjct: 167 SENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAP 226
Query: 880 VEAEVKRLH---------NTIVEINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTA 930
V+ E+K L N + NH L K + I+ +L + + ++ + A
Sbjct: 227 VDQEIKSLREKLNKLRQQNACLVTQNHSLMT---KFESIHFELTQSRAKVSMLESA---- 279
Query: 931 DRNLQKAQDSVLRTEKEIKDTEKEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEH 990
Q+ SV E++I + E EV L+ E+K + K E+SL E ++E
Sbjct: 280 ----QQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEEC 335
Query: 991 RNLLQEL-------KVIQENEHALQKDALSIKLKLEQIDGHIAEHNSKIKYWHKEISKIS 1043
L +L K + + +A + +Q +AE K++ +EI + +
Sbjct: 336 IKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQA-EEEILERN 394
Query: 1044 LHPI--EDNPIEEISVLSPEDLEAIK 1067
L E+ ++E L +LE +K
Sbjct: 395 LTNCEKENKRLQERCGLYKSELEILK 420
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 93.2 bits (230), Expect = 1e-18
Identities = 152/760 (20%), Positives = 324/760 (42%), Gaps = 106/760 (13%)
Query: 281 RGEKLNRVKMVEKEK-DALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRIAEMET 339
R ++L + M EKE+ + + I L E+ +F+ K HV ++Q + ++
Sbjct: 354 RCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQV-- 411
Query: 340 QKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEK-KLNKI----TKFIEENKEKFTQLD 394
+E++ + + +++ IL + + ++ + +LNK+ + + E EK +L
Sbjct: 412 -REQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQ 470
Query: 395 LEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKE 454
E+VQ K+A A +L+ QLQ+ + + EE +S I + T + A +++ +
Sbjct: 471 QEEVQK----KNAEQAATQLKVQLQEAERRWEEVQSY-------IRKRTAEHEAAQQDLQ 519
Query: 455 KEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHN 514
+ + + SL + K+ E+ LM +S + +K + Q ++ L ++
Sbjct: 520 SKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNE 579
Query: 515 TAVSQLTKAKEALIAAS----------ETLKERKAAIRDIEGKLPQTEQELKEKEKELQK 564
+Q+ + + A + + + E+ I+ E L L KE+EL+
Sbjct: 580 ALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKD 639
Query: 565 LTQEETNFKSLVHDL----------FQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPG 614
+ K+ V L ++E+ + S+ + + ++L+ +Q + S ++
Sbjct: 640 IQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEE 699
Query: 615 IYGRLGDLGAIDEKYDVAISSCCHALDYIVV-----DSIDIAQECVNFL--KRQNIGVAT 667
I + A+ S L +V D ++ ++C+ K + +
Sbjct: 700 F--------KILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELL 751
Query: 668 FIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRV 727
GL ++A +++ I+T EN+ ++ +K ++ Q + +L +++ +V
Sbjct: 752 ETGLIQVATKEEELNAIRT-ENSSLTKEVQDLKAKQNDQVSFASL--------VEELKKV 802
Query: 728 AYQKDRRWRVVT--LQGQII-----EQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKME 780
++KD + + V L+ +++ E++ K +K +G+ + + + +
Sbjct: 803 IHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKV 862
Query: 781 SQLQNDSK-KAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLNVQV 839
+LQN K K Q+ K LEE+ E+++ NT + +Q L E+ E L V
Sbjct: 863 QELQNLLKGKEEQMNTMKAVLEEK-------EKDLANTGKW----LQDLQEENESLKAHV 911
Query: 840 KELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIVEINNHKL 899
+E+ + L A + S F+ + EK E E+KRL + E L
Sbjct: 912 QEVAQHNLKEA----------SSASQFEELEIVLKEK----ENELKRLEAMLKE-RESDL 956
Query: 900 KAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTE--KEIKDTEKEVDD 957
++ L + + + + K+Q+ + +N Q+A E K I + EKE+
Sbjct: 957 SSKTQLLQDVQDE-----NKLFKSQIE-QLKQQNYQQASSFPPHEELLKVISEREKEISG 1010
Query: 958 LTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQEL 997
L EL SL+D K N ++ + ++ E + +L++L
Sbjct: 1011 LWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKL 1050
Score = 75.9 bits (185), Expect = 2e-13
Identities = 162/899 (18%), Positives = 361/899 (40%), Gaps = 157/899 (17%)
Query: 310 TLENEIFRKKNHVCQYYIYELQKRIAEMETQKEK------IHEDTKEINEKSNILSNEMK 363
TL +E+ K+ + + K+ AE + K+K +HE E + LS+ +
Sbjct: 32 TLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALA 91
Query: 364 AKN--------------KDVKDTEKKLNKITKFIEE------NKEKFTQLDLEDVQVREK 403
++ V++ +KK K +EE + K +E V V ++
Sbjct: 92 VEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQ 151
Query: 404 ----LKHATSKAK---KLEKQLQKDKEKVEEFKSIPAKSNNII---NETTTRNNALEKEK 453
+ A SK K K K D++K E +P+K + ET + + +K+
Sbjct: 152 PTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKA 211
Query: 454 EKEEKKLKEV---------------MDSLKQETQGLQKEKESREK--ELMGFSKSVNEAR 496
+++K + V MD+ ++E K ++ G KS + +
Sbjct: 212 SSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTK-K 270
Query: 497 SKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDI-----EGKLPQT 551
K + + ++ ++ + +++ + + LKE+ I+D +G+L
Sbjct: 271 LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTL 330
Query: 552 EQELKEKEKELQKLTQEETNFKSLVHDLFQKV--EEAKSSLAMNRSRGKVLDAIIQEKKS 609
+L+EK+K L + ++ K L Q++ E+ +S++ + R + ++
Sbjct: 331 IHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRI---------- 380
Query: 610 GRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECVN--------FLKRQ 661
G ++++++V + H + Y + + + V LK++
Sbjct: 381 -------------GTLEKEHNV-FQNKIH-VSYQETQQMQMKFQQVREQMEAEIAHLKQE 425
Query: 662 NIGVATFIGLDKMAVWAKKMTEI-QTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADN 720
N + + + +K+ E+ + ++ RL + + K K++Q + + N
Sbjct: 426 NGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQ-------EEVQKKN 478
Query: 721 LDQAT---RVAYQK-DRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEV 776
+QA +V Q+ +RRW V S + K + + +
Sbjct: 479 AEQAATQLKVQLQEAERRWEEVQ----------------SYIRKRTAEHEAAQQDLQSKF 522
Query: 777 NKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYLN 836
E+++Q+ K K QLE+R+++L SE++ N E +Q ++EQ E L
Sbjct: 523 VAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALK 582
Query: 837 VQVK----ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAGKVEAEVKRLHNTIV 892
Q++ ++ A A+ ++ K++ E K D++A + ++ ++ + L + +
Sbjct: 583 AQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKD--I 640
Query: 893 EINNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQDSVLRTEKEIKDTE 952
+ N LKA+ KL + + A + K Q ++ D ++ ++ + + EI +
Sbjct: 641 QNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQL---QHEISNKM 697
Query: 953 KEVDDLTAELKSLEDKAAEVVKNTNAAEESLPEIQKEHRNLLQE----LKVIQENEHALQ 1008
+E L + K+L+ + ++ T +E+ ++ ++ +QE LK ++E L+
Sbjct: 698 EEFKILNDQNKALKSEVQKL--QTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEE---LLE 752
Query: 1009 KDALSIKLKLEQIDGHIAEHNSKIKYWH----KEISKISLHPI----------EDNPIEE 1054
+ + K E+++ E++S K K+ ++S + +D I+
Sbjct: 753 TGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKS 812
Query: 1055 ISVLSPEDLEAIKNPDSITNQIALLEARCHEMKPNLGAIAEYKKKEELYLQRVAELDKI 1113
+ L +L + N + L+ +K +G + K ++ +V EL +
Sbjct: 813 VEELLEAELLKVANKEKTVQD---LKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNL 868
Score = 73.9 bits (180), Expect = 9e-13
Identities = 122/626 (19%), Positives = 261/626 (41%), Gaps = 77/626 (12%)
Query: 219 DLDHNRFLILQGEVEQI-AMMKPKGQTEHDEGMLE---YLEDIIGCGRLNEPIKVLCRRV 274
D+ + FL L+ EV+++ A+ + H+ ++ Y++D + I++L
Sbjct: 639 DIQNMNFL-LKAEVQKLQALANEQAAAAHELEKMQQSVYVKD--------DKIRLL---E 686
Query: 275 EILNEHRGEKLNRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIYELQKRI 334
E L K+ K++ + AL+ E + TL +E + V + +Q++
Sbjct: 687 EQLQHEISNKMEEFKILNDQNKALKSEVQ---KLQTLVSE--QPNKDVVEQMEKCIQEKD 741
Query: 335 AEMETQKEKIHEDTKEI---NEKSNILSNEMKAKNKDVKDTEKKLNKITKF---IEENKE 388
+++T +E + ++ E+ N + E + K+V+D + K N F +EE K+
Sbjct: 742 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKK 801
Query: 389 KFTQLDLEDVQVREKLKHATSKAKKLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNA 448
+ D + V E L+ K EK +Q K+ E K++ + N+ E + +
Sbjct: 802 VIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ---EIKALKEEIGNVQLEKAQQLSI 858
Query: 449 LEKEKEKEEKKLKEVMDSLKQETQGLQKEKESREKELMGFSKSVNEARSKMDVAQSELDI 508
K +E L+ ++ +++ ++ E +EK+L K + + + + + ++ +
Sbjct: 859 TSKVQE-----LQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE 913
Query: 509 YLSRHNTAVSQLTKAKEALIAASETLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQE 568
+ S ++ +E I LKE++ ++ +E L + E +L K + LQ + E
Sbjct: 914 VAQHNLKEASSASQFEELEIV----LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDE 969
Query: 569 ETNFKSLVHDLFQKVEEAKSSLAMNRSRGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEK 628
FKS + L Q+ + SS + KV+ ++ I G++ L L E
Sbjct: 970 NKLFKSQIEQLKQQNYQQASSFPPHEELLKVI-----SEREKEISGLWNELDSLKDAVEH 1024
Query: 629 YDVAISSCCHALDYIVVDSIDIAQECV----------------NFLKRQNIGVATFIGLD 672
+ ++ + +++ ++ ++ F K+ +A G +
Sbjct: 1025 QRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE 1084
Query: 673 KMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDTLVADNLDQATRVAYQKD 732
++ V K+ E + L++++ EK + L +T L + R Q++
Sbjct: 1085 EVKVLEHKLKE------ADEMHTLLQLECEKYKS----VLAET--EGILQKLQRSVEQEE 1132
Query: 733 RRWRV-VTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEEVNKMESQLQ----NDS 787
+W+V V + I+Q + + ++ + IE E +E +L+ S
Sbjct: 1133 NKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERS 1192
Query: 788 KKAMQIQEQKVQLEERVVKLRHSERE 813
+++E K QL E + KLR + E
Sbjct: 1193 TYVTEVRELKAQLNETLTKLRTEQNE 1218
Score = 64.3 bits (155), Expect = 7e-10
Identities = 121/656 (18%), Positives = 269/656 (41%), Gaps = 79/656 (12%)
Query: 326 YIYELQKRIAEMETQKEKIH--EDTKEINEKSNILSNEMKAKNKDVKDTEKK--LNKITK 381
Y+ + + R+ E + Q E + E+ K +N+++ L +E++ V + K + ++ K
Sbjct: 676 YVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEK 735
Query: 382 FIEENKEKFTQLD-------LEDVQVREKLKHATSKAKKLEKQLQKDKEKVEE---FKSI 431
I+E EK ++ ++ E+L ++ L K++Q K K + F S+
Sbjct: 736 CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASL 795
Query: 432 PAKSNNIINETTTRNNALEK----------EKEKEEKKLKEVMDSLKQETQGLQKEKE-- 479
+ +I+E + ++E+ KEK + LK+ + +LK+E +Q EK
Sbjct: 796 VEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQ 855
Query: 480 ----SREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASETLK 535
S+ +EL K E + M E + L+ + L + E+L A + +
Sbjct: 856 LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA 915
Query: 536 ERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAKSSLAMNRS 595
+ + + E LKEKE EL++L E K DL K + + N+
Sbjct: 916 QHNLKEASSASQFEELEIVLKEKENELKRL---EAMLKERESDLSSKTQLLQDVQDENKL 972
Query: 596 RGKVLDAIIQEKKSGRIPGIYGRLGDLGAIDEKYDVAISSCCHALDYIVVDSIDIAQECV 655
++ + Q+ + +L + + + IS + LD + D+++ ++
Sbjct: 973 FKSQIEQLKQQNYQQA--SSFPPHEELLKVISEREKEISGLWNELDSLK-DAVEHQRKKN 1029
Query: 656 NFLKRQNIGVATFIGLDKMAVWAKKMTEIQTPENTPRLFDLVKVKDEKIRQAFYFALRDT 715
N ++Q + L+ V K ++ P N + + ++K ++ + T
Sbjct: 1030 NERQQQ----VEAVELEAKEVLKKLFPKVSVPSNLS-YGEWLHGFEKKAKEC----MAGT 1080
Query: 716 LVADNLDQATRVAYQKDRRWRVVTLQGQIIEQSGTMTGGGSKVMKGRMGSSLVIEISEEE 775
++ + + D ++ L+ + + T G + ++ + E+E
Sbjct: 1081 SGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSV---------EQE 1131
Query: 776 VNKMESQLQNDSKKAMQIQEQKVQLEERVVKLRHSEREMRNTLEKFTASIQRLIEQEEYL 835
NK + ++ K Q+Q E+ + +LR +++ N L + E+L
Sbjct: 1132 ENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIEN-----------LRREREHL 1180
Query: 836 NVQVK--ELEANVLATAPDKKKQKLLEENVSAFKTEYDAVAEKAG---KVEAEVKRLHNT 890
++++ E+E + T + K + L E ++ +TE + + AG K + ++ + +
Sbjct: 1181 EMELEKAEMERSTYVTEVRELKAQ-LNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK 1239
Query: 891 IVE-------INNHKLKAQQDKLDKINKQLDECASAITKAQVAIKTADRNLQKAQD 939
IV+ I N + + + +K + +T+ Q ++ ++ L K ++
Sbjct: 1240 IVKAAGDTTVIENSDVSPETESSEKETMSV-SLNQTVTQLQQLLQAVNQQLTKEKE 1294
Score = 57.4 bits (137), Expect = 9e-08
Identities = 86/475 (18%), Positives = 191/475 (40%), Gaps = 91/475 (19%)
Query: 199 ISGKKKTFKDVGNLLRS-----HGIDLDHNRFLILQGEVEQIAMMKPKGQTEHDEGMLEY 253
++ K+KT +D+ +++ + L+ + L + +V+++ + KG+ E M
Sbjct: 824 VANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLL-KGKEEQMNTMKAV 882
Query: 254 LE----DIIGCGRL-------NEPIKVLCRRV-----------------EILNEHRGEKL 285
LE D+ G+ NE +K + V EI+ + + +L
Sbjct: 883 LEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENEL 942
Query: 286 NRVKMVEKEKDALEGEKNIAIEFLTLENEIFRKKNHVCQYYIY----------------- 328
R++ + KE+++ K ++ + EN++F+ + + Y
Sbjct: 943 KRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVIS 1002
Query: 329 ELQKRIAEMETQKEKIHEDTKEINEKSNILSNEMKAKNKDVKDTEKKL------------ 376
E +K I+ + + + + + + +K+N +++A + K+ KKL
Sbjct: 1003 EREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLSY 1062
Query: 377 --------------------NKITKFIE----ENKEKFTQLDLEDVQVREKLKHATSKAK 412
++ K +E E E T L LE + + L +
Sbjct: 1063 GEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQ 1122
Query: 413 KLEKQLQKDKEKVEEFKSIPAKSNNIINETTTRNNALEKEKEKEEKKLKEVMDSLKQETQ 472
KL++ +++++ K +K +S+ I + + + E+E E+ + K++ ++L++E +
Sbjct: 1123 KLQRSVEQEENK---WKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDI-ENLRRERE 1178
Query: 473 GLQKEKESREKELMGFSKSVNEARSKMDVAQSELDIYLSRHNTAVSQLTKAKEALIAASE 532
L+ E E E E + V E +++++ ++L + L KA+++L
Sbjct: 1179 HLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQS 1238
Query: 533 TLKERKAAIRDIEGKLPQTEQELKEKEKELQKLTQEETNFKSLVHDLFQKVEEAK 587
+ + IE E E EKE L Q T + L+ + Q++ + K
Sbjct: 1239 KIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEK 1293
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.350
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,120,239
Number of Sequences: 37866
Number of extensions: 2271446
Number of successful extensions: 39564
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 521
Number of HSP's successfully gapped in prelim test: 1489
Number of HSP's that attempted gapping in prelim test: 16971
Number of HSP's gapped (non-prelim): 12209
length of query: 1288
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1174
effective length of database: 13,930,794
effective search space: 16354752156
effective search space used: 16354752156
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.