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Search of human proteins with 50348626
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50348626 mitochondrial tumor suppressor 1 isoform 4 [Homo
sapiens]
(517 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50348626 mitochondrial tumor suppressor 1 isoform 4 [Homo sap... 1010 0.0
gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo sap... 885 0.0
gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo sap... 884 0.0
gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo sap... 770 0.0
gi|140161498 hypothetical protein LOC23281 isoform a [Homo sapiens] 238 1e-62
gi|57768564 hypothetical protein LOC23281 isoform b [Homo sapiens] 219 4e-57
gi|45935391 coiled-coil domain containing 69 [Homo sapiens] 112 8e-25
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 77 3e-14
gi|71061468 centromere protein E [Homo sapiens] 77 5e-14
gi|56961680 coiled-coil domain containing 147 [Homo sapiens] 77 5e-14
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 74 2e-13
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 74 3e-13
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 73 5e-13
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 73 5e-13
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 73 5e-13
gi|55770834 centromere protein F [Homo sapiens] 73 5e-13
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 73 7e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 72 9e-13
gi|31982906 cingulin-like 1 [Homo sapiens] 72 1e-12
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 72 2e-12
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 72 2e-12
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 71 2e-12
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 71 2e-12
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 71 2e-12
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 71 2e-12
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 71 2e-12
gi|21735548 centrosomal protein 2 [Homo sapiens] 71 3e-12
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 70 6e-12
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 70 6e-12
gi|124249396 coiled-coil domain containing 30 [Homo sapiens] 69 8e-12
>gi|50348626 mitochondrial tumor suppressor 1 isoform 4 [Homo
sapiens]
Length = 517
Score = 1010 bits (2612), Expect = 0.0
Identities = 517/517 (100%), Positives = 517/517 (100%)
Query: 1 MTVPGGFRSCTETDISSKIFINSTLTPPAGSERHYDATLLTLLVVGSYSLCIIPLLATFT 60
MTVPGGFRSCTETDISSKIFINSTLTPPAGSERHYDATLLTLLVVGSYSLCIIPLLATFT
Sbjct: 1 MTVPGGFRSCTETDISSKIFINSTLTPPAGSERHYDATLLTLLVVGSYSLCIIPLLATFT 60
Query: 61 GKKTGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNLFTALN 120
GKKTGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNLFTALN
Sbjct: 61 GKKTGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNLFTALN 120
Query: 121 AVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKF 180
AVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKF
Sbjct: 121 AVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKF 180
Query: 181 EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFV 240
EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFV
Sbjct: 181 EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFV 240
Query: 241 QQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEA 300
QQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEA
Sbjct: 241 QQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEA 300
Query: 301 SHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKL 360
SHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKL
Sbjct: 301 SHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKL 360
Query: 361 KSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTA 420
KSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTA
Sbjct: 361 KSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTA 420
Query: 421 LVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWK 480
LVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWK
Sbjct: 421 LVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWK 480
Query: 481 LHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR 517
LHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR
Sbjct: 481 LHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR 517
>gi|50348611 mitochondrial tumor suppressor 1 isoform 1 [Homo sapiens]
Length = 1270
Score = 885 bits (2287), Expect = 0.0
Identities = 455/462 (98%), Positives = 459/462 (99%), Gaps = 1/462 (0%)
Query: 56 LATFTGKKTGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNL 115
L+T++ +GNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNL
Sbjct: 810 LSTYSNN-SGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNL 868
Query: 116 FTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLAC 175
FTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLAC
Sbjct: 869 FTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLAC 928
Query: 176 GNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTV 235
GNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTV
Sbjct: 929 GNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTV 988
Query: 236 YEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSK 295
YEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSK
Sbjct: 989 YEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSK 1048
Query: 296 LEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDA 355
LEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDA
Sbjct: 1049 LEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDA 1108
Query: 356 LNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLV 415
LNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLV
Sbjct: 1109 LNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLV 1168
Query: 416 DNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENE 475
DNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENE
Sbjct: 1169 DNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENE 1228
Query: 476 ELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR 517
ELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR
Sbjct: 1229 ELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR 1270
>gi|50348617 mitochondrial tumor suppressor 1 isoform 2 [Homo sapiens]
Length = 1216
Score = 884 bits (2284), Expect = 0.0
Identities = 453/453 (100%), Positives = 453/453 (100%)
Query: 65 GNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNLFTALNAVEK 124
GNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNLFTALNAVEK
Sbjct: 764 GNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNLFTALNAVEK 823
Query: 125 SRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALT 184
SRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALT
Sbjct: 824 SRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALT 883
Query: 185 VVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQ 244
VVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQ
Sbjct: 884 VVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQ 943
Query: 245 AEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSE 304
AEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSE
Sbjct: 944 AEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSE 1003
Query: 305 KLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEE 364
KLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEE
Sbjct: 1004 KLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEE 1063
Query: 365 QKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDK 424
QKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDK
Sbjct: 1064 QKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDK 1123
Query: 425 LKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNG 484
LKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNG
Sbjct: 1124 LKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNG 1183
Query: 485 DLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR 517
DLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR
Sbjct: 1184 DLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR 1216
>gi|17865632 mitochondrial tumor suppressor 1 isoform 5 [Homo
sapiens]
Length = 436
Score = 770 bits (1989), Expect = 0.0
Identities = 404/436 (92%), Positives = 409/436 (93%), Gaps = 11/436 (2%)
Query: 91 LKPLVSRAHVHLMKTP---------PKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAP 141
L P S + +H+ T P G R + + VEKSRQKNPRSLCIQPQTAP
Sbjct: 3 LSPKFSLSTIHIRLTAKGLLRNLRLPSGFRRSTV--VFHTVEKSRQKNPRSLCIQPQTAP 60
Query: 142 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 201
DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH
Sbjct: 61 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 120
Query: 202 KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE 261
KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE
Sbjct: 121 KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTRE 180
Query: 262 YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK 321
YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK
Sbjct: 181 YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK 240
Query: 322 KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM 381
KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM
Sbjct: 241 KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM 300
Query: 382 YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 441
YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK
Sbjct: 301 YLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 360
Query: 442 HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ 501
HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ
Sbjct: 361 HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ 420
Query: 502 SPRNSGSFPSPSISPR 517
SPRNSGSFPSPSISPR
Sbjct: 421 SPRNSGSFPSPSISPR 436
>gi|140161498 hypothetical protein LOC23281 isoform a [Homo sapiens]
Length = 1379
Score = 238 bits (606), Expect = 1e-62
Identities = 140/382 (36%), Positives = 229/382 (59%), Gaps = 13/382 (3%)
Query: 137 PQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREE 196
P+ P A E+ L L + K +CE Q+ + + L F+AL V QH + E
Sbjct: 994 PKPDPQAREAERQLVL-RLKERCEQQTRQLGVAQGELKRAICGFDALAVATQHFFRKNES 1052
Query: 197 ALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQ----QHQAEKTEREN 252
AL + K LS EL N+R E+ + CEKL+K + EL+ +E V+ Q QAE E E
Sbjct: 1053 ALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQQQAELQELEE 1112
Query: 253 RLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKA 312
RL+ + E +L++ + ++ + Q QEQ ++L A+H+ + LE+E +H+ + +L+
Sbjct: 1113 RLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNHTVAITILQDD 1172
Query: 313 YEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQ--KRRAR 370
++ + E+ HE+EKK LE+ + + SL+ Q++ L ++ +L ++ + E+ ++
Sbjct: 1173 HDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARRFEEALRKNTE 1232
Query: 371 EKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQ 430
E+ + +LE++++SLK VLE+KN+++H+Q+ K++++EKL + N L +K++ QQ
Sbjct: 1233 EQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNIILEEKIQVLQQ 1292
Query: 431 ENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSP- 489
+NE+LKAR+D++ ++RQLS E A LQE +EKE++ KRLS NEELLWKL GD SP
Sbjct: 1293 QNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWKLQTGDPTSPI 1352
Query: 490 KRSPTSSAIPLQSPRNSGSFPS 511
K SPTS R S S PS
Sbjct: 1353 KLSPTSPVY-----RGSSSGPS 1369
>gi|57768564 hypothetical protein LOC23281 isoform b [Homo sapiens]
Length = 348
Score = 219 bits (559), Expect = 4e-57
Identities = 125/332 (37%), Positives = 206/332 (62%), Gaps = 12/332 (3%)
Query: 187 IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQ----Q 242
+Q L E AL + K LS EL N+R E+ + CEKL+K + EL+ +E V+ Q
Sbjct: 12 LQCLDKTNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKRLGWQ 71
Query: 243 HQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASH 302
QAE E E RL+ + E +L++ + ++ + Q QEQ ++L A+H+ + LE+E +H
Sbjct: 72 QQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALLEMENNH 131
Query: 303 SEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKS 362
+ + +L+ ++ + E+ HE+EKK LE+ + + SL+ Q++ L ++ +L ++ +
Sbjct: 132 TVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQSLRDRARR 191
Query: 363 EEQ--KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTA 420
E+ ++ E+ + +LE++++SLK VLE+KN+++H+Q+ K++++EKL + N
Sbjct: 192 FEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILELEKLAEKNII 251
Query: 421 LVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWK 480
L +K++ QQ+NE+LKAR+D++ ++RQLS E A LQE +EKE++ KRLS NEELLWK
Sbjct: 252 LEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKRLSRTNEELLWK 311
Query: 481 LHNGDLCSP-KRSPTSSAIPLQSPRNSGSFPS 511
L GD SP K SPTS R S S PS
Sbjct: 312 LQTGDPTSPIKLSPTSPVY-----RGSSSGPS 338
>gi|45935391 coiled-coil domain containing 69 [Homo sapiens]
Length = 296
Score = 112 bits (280), Expect = 8e-25
Identities = 68/229 (29%), Positives = 130/229 (56%), Gaps = 13/229 (5%)
Query: 256 EFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEA 315
E + ++ ++ + EE +K+ Q++++ +LE+ E+ +L+ E
Sbjct: 54 ERHQKDITRILQQHEEEKKKWAQQVEKE----------RELELRDRLDEQQRVLEGKNEE 103
Query: 316 SLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRARE-KAN 374
+L ++ +E EK++L E + ++ I+ L S+ +A K+K E+ +R K +
Sbjct: 104 ALQVLRASYEQEKEALTHSFREASSTQQETIDRLTSQLEAFQAKMKRVEESILSRNYKKH 163
Query: 375 LKN--PQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN 432
+++ + EQELESL V+E+KNE++H+ D +L+ ME + + N L +K+ QQEN
Sbjct: 164 IQDYGSPSQFWEQELESLHFVIEMKNERIHELDRRLILMETVKEKNLILEEKITTLQQEN 223
Query: 433 EELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 481
E+L R + +SRQLS + + +E+LEKE ++ ++L E EELL+++
Sbjct: 224 EDLHVRSRNQVVLSRQLSEDLLLTREALEKEVQLRRQLQQEKEELLYRV 272
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 77.4 bits (189), Expect = 3e-14
Identities = 81/322 (25%), Positives = 151/322 (46%), Gaps = 61/322 (18%)
Query: 187 IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAE 246
+Q L R+EALK++K+L +EL RG T E+L K+ ++++ Q A+
Sbjct: 1485 LQAALISRKEALKENKSLQEELSLARG-------TIERLTKSLADVES-------QVSAQ 1530
Query: 247 KTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKL 306
E++ L + E RD I E ++ ++ Q +L+++ E+ KL +E +K
Sbjct: 1531 NKEKDTVLGRLALLQEE--RDKLITEMDRSLLENQ----SLSSSCESLKLALEGLTEDKE 1584
Query: 307 ELLKK-------------AYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSEN 353
+L+K+ ++ E++K +EI +S E+ +S + E ++ + ++ E
Sbjct: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYEN-VSNEAERIQHVVEAVRQEK 1643
Query: 354 DALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLK--------------AVLEIKNE 399
L KL+S E ++ EK Q+ EQE+E +K LE +N+
Sbjct: 1644 QELYGKLRSTEANKKETEK------QLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEND 1697
Query: 400 KLHQQ-----DIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQA 454
+L + D ME L+ +N ++ ++L+R + E E L + M+ LS E
Sbjct: 1698 RLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQ 1757
Query: 455 VLQESLEKESKVNKRLSMENEE 476
L+ + E V+K+ ++E E
Sbjct: 1758 DLKHQI--EGNVSKQANLEATE 1777
Score = 59.3 bits (142), Expect = 8e-09
Identities = 80/375 (21%), Positives = 165/375 (44%), Gaps = 69/375 (18%)
Query: 148 KTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHK-TLSQ 206
K EL+Q ++ E + I ++ QLL E L Q + E+++ + + ++++
Sbjct: 860 KVEELSQALSQKELE---ITKMDQLLLEKKRDVETL----QQTIEEKDQQVTEISFSMTE 912
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 266
++V L E + + L++ N L EA + E+ E +N + + Y+++
Sbjct: 913 KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEA-----KKEQVEEDNEVSSGLKQNYDEMS 967
Query: 267 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKA-------------- 312
+ K +LQ +FD L +E K +++A+ + ELL++
Sbjct: 968 PA----GQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDES 1023
Query: 313 -YEASLSEIKKGHEIE-----KKSLEDLLSEKQESLEKQINDLKSENDA--------LNE 358
E LSE ++G E+E K+ E ++ K + +E + SE + L E
Sbjct: 1024 KKEIPLSETERG-EVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEE 1082
Query: 359 KLKSEEQKRRAREKANL----KNPQIMYLEQELESLKAVLE---IKNEKLHQQDIKLMKM 411
KL +EEQ + ++ N K QI L+ E+ +A+++ N D +
Sbjct: 1083 KLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVK 1142
Query: 412 EKLVDN----------NTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLE 461
E +V + L +K+ ++E E+L+ ++ + L++ +A+L+++ E
Sbjct: 1143 ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQE------ALTSRKAILKKAQE 1196
Query: 462 KESKVNKRLSMENEE 476
KE + + L + ++
Sbjct: 1197 KERHLREELKQQKDD 1211
Score = 53.9 bits (128), Expect = 3e-07
Identities = 77/353 (21%), Positives = 150/353 (42%), Gaps = 59/353 (16%)
Query: 188 QHLLSEREEALKQHKT-------LSQELVNLRGELVTASTTCEKLEKARNELQTV----- 235
+ LLS+ EE + + L EL +L+ +L S + EK ++ + L+ +
Sbjct: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE 2346
Query: 236 ---------YEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQE---- 282
YE QA + E +RL E + +K+ + E ++ + E
Sbjct: 2347 ADIQNSKFSYEQLETDLQASR-ELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQ 2405
Query: 283 ------QFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDL-- 334
+ +NL + E + +E + + ++ + E +L IKK + +K L+
Sbjct: 2406 HDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLME-TLKTIKKENIQQKAQLDSFVK 2464
Query: 335 ------------------LSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAR-EKANL 375
L E+ S+ + + L E A N KLK E + R+ + N
Sbjct: 2465 SMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNS 2524
Query: 376 KNPQI-MYLEQELESLKAVLEIKNEKLHQQ-DIKLMKMEKLVDNNTALVDKLKRFQQENE 433
+N ++ L Q E L V+ IK+ + Q +++L + ++L + L +KLK ++ NE
Sbjct: 2525 ENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANE 2584
Query: 434 ELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDL 486
+L+ + + LS E L+ S+ S++ ++++ EE L++ L
Sbjct: 2585 DLRRSFNALQEEKQDLSKEIESLKVSI---SQLTRQVTALQEEGTLGLYHAQL 2634
Score = 51.6 bits (122), Expect = 2e-06
Identities = 66/293 (22%), Positives = 136/293 (46%), Gaps = 24/293 (8%)
Query: 200 QHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYT 259
Q K + E V L EL +STT E +K+ Q + Q + E + + E +
Sbjct: 1310 QLKEIEAEKVEL--ELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHA 1367
Query: 260 REYE-KLRDTYIEEAE-KYKMQLQEQFDNLNAAHETSKLEIEASH-----SEKLELLKKA 312
+ KL + ++ A ++ +LQ + D L SK E + S+ SEK L K
Sbjct: 1368 ESLQQKLESSQLQIAGLEHLRELQPKLDELQKL--ISKKEEDVSYLSGQLSEKEAALTKI 1425
Query: 313 YEASLSE---IKKGH-EIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRR 368
+ + IK H ++E ++ E E+ + L+ ++ ++K + + + E+ ++++Q +R
Sbjct: 1426 QTEIIEQEDLIKALHTQLEMQAKEH--DERIKQLQVELCEMKQKPEEIGEESRAKQQIQR 1483
Query: 369 AREKANLKNPQIMY----LEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDK 424
+ A + + + L++EL + +E + L + ++ K D ++ +
Sbjct: 1484 KLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT---VLGR 1540
Query: 425 LKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 477
L Q+E ++L MD+ + ++ LS+ L+ +LE ++ ++L E E L
Sbjct: 1541 LALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESL 1593
Score = 50.1 bits (118), Expect = 5e-06
Identities = 74/349 (21%), Positives = 146/349 (41%), Gaps = 47/349 (13%)
Query: 168 QLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEK 227
++K L C + E +++ E K++ Q G A E L++
Sbjct: 1957 EMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKE 2016
Query: 228 ARNELQTVYEAFVQ-QHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDN 286
+ E++ + + ++ Q + ER + EF E +K +E ++ Q E
Sbjct: 2017 KQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK----DLEITKENLAQAVEHRKK 2072
Query: 287 LNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQI 346
A + K+ ++ + SE +L A ++KK + K+S++ + +K E LE+++
Sbjct: 2073 AQAELASFKVLLDDTQSEAARVL-----ADNLKLKKELQSNKESVKSQMKQKDEDLERRL 2127
Query: 347 -----------NDLKSENDAL-NEKLKSEEQKRRAREKANLKNPQIMYLEQELESL---- 390
+++ + DAL EK+ EE + N K+ ++ L++ L+S
Sbjct: 2128 EQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQL 2187
Query: 391 ---------------KAVLEIKNEKLHQQDIKLMKMEKL---VDNNTALVDKLKRFQQEN 432
+ + E K + D K E++ DN + L D+L++
Sbjct: 2188 AAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHM 2247
Query: 433 EELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 481
EELK + + + +Q+ +A Q ++ + KV L EN+ELL +L
Sbjct: 2248 EELKINISR-LEHDKQIWESKA--QTEVQLQQKVCDTLQGENKELLSQL 2293
Score = 50.1 bits (118), Expect = 5e-06
Identities = 62/346 (17%), Positives = 147/346 (42%), Gaps = 29/346 (8%)
Query: 155 YKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGE 214
Y+ E IL+ QL+ + L I+ L S ++ ++ L EL+ R +
Sbjct: 2480 YQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRED 2539
Query: 215 LVTASTTCEKLEKARNELQTVYEAFVQQHQA---EKTERENRLKEFYTREYEKLRD---T 268
L T + +K E+Q ++ A EK + E R + L++
Sbjct: 2540 LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQD 2599
Query: 269 YIEEAEKYKMQLQEQFDNLNAAHET-------SKLEIEASHSEKLELLKKAYEASLSEIK 321
+E E K+ + + + A E ++L+++ +L L + + ++E++
Sbjct: 2600 LSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELE 2659
Query: 322 KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQK--RRAREKANLKNPQ 379
+ +K + E ++ L+K++ L + + + ++ E++ AR+ ++
Sbjct: 2660 EELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKL 2719
Query: 380 IMY------LEQELESL-KAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN 432
+M L +++S +++ ++N + H + +L ++++ D + LK Q
Sbjct: 2720 LMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE-ELDELKRKYDAS------LKELAQLK 2772
Query: 433 EELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELL 478
E+ ++ +S + + + SL K+N++L ++E+LL
Sbjct: 2773 EQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLL 2818
Score = 48.5 bits (114), Expect = 1e-05
Identities = 60/262 (22%), Positives = 121/262 (46%), Gaps = 29/262 (11%)
Query: 244 QAEKTERENRLKEFYTREYEKLR--DTYIEEAEKY-------KMQLQEQFDNLNAAHETS 294
Q E+ +N++K+ KL + YIEE + + Q +EQ + +
Sbjct: 83 QEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE 142
Query: 295 KLEIEASH---SEKLELLKKAYEASLSEIKKGHEIEKKS-LEDLLSEKQESLEKQ--IND 348
++EIE EK EL+ +A L++ + + + +E+ + KQ+ EK+ I+
Sbjct: 143 EMEIEKIKHKLQEKEELIS-TLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFIST 201
Query: 349 LKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKL 408
L+++ L++ + ++ REK Q+ E EL L +++ E QQ +++
Sbjct: 202 LQAQ---LSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEM--QQKLRV 256
Query: 409 MKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQL---STEQAVLQESLEKESK 465
++ KL ++ +LV + + +EL A ++ +S+QL E L+ ++E E +
Sbjct: 257 LQ-RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETERE 315
Query: 466 VNK----RLSMENEELLWKLHN 483
+K ++ +E E HN
Sbjct: 316 ESKILLEKMELEVAERKLSFHN 337
Score = 48.1 bits (113), Expect = 2e-05
Identities = 75/356 (21%), Positives = 147/356 (41%), Gaps = 41/356 (11%)
Query: 150 LELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELV 209
LE+ KT L+Q L + L ++ L + +E K +++
Sbjct: 1351 LEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEH-LRELQPKLDELQKLISKKEEDVS 1409
Query: 210 NLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYE-KLRDT 268
L G+L K++ E + + +A Q + + E + R+K+ E K +
Sbjct: 1410 YLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPE 1469
Query: 269 YIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHS--EKLELLKKAYEA---SLSEIKKG 323
I E + K Q+Q + L AA + K ++ + S E+L L + E SL++++
Sbjct: 1470 EIGEESRAKQQIQRK---LQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQ 1526
Query: 324 HEIEKKSLED------LLSEKQESLEKQINDLKSENDALNEKLKS---------EEQKRR 368
+ K + LL E+++ L +++ EN +L+ +S E++++
Sbjct: 1527 VSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKL 1586
Query: 369 AREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRF 428
+E +LK+ +I + E K E + +I L E + + + ++
Sbjct: 1587 VKEIESLKSSKIAESTEWQEKHK-------ELQKEYEILLQSYENVSNEAERIQHVVEAV 1639
Query: 429 QQENEELKARMDKHMA----ISRQLSTEQAVLQESLEK-----ESKVNKRLSMENE 475
+QE +EL ++ A +QL + ++E EK +SK K L +E E
Sbjct: 1640 RQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEE 1695
Score = 45.4 bits (106), Expect = 1e-04
Identities = 49/220 (22%), Positives = 98/220 (44%), Gaps = 14/220 (6%)
Query: 271 EEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKS 330
E ++ QE A E +E++ +K L++ EA L E +K + + K
Sbjct: 37 ESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEA-LQEERKAADNKIKK 95
Query: 331 LEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESL 390
L+ K SL K I ++K++ + E++ +K++ + E E+E +
Sbjct: 96 LKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE------EMEIEKI 149
Query: 391 KAVLEIKNEKLH--QQDIKLMKMEKLVDNNTALVD--KLKRFQQENEELKARMDKHMAIS 446
K L+ K E + Q + + E+ ++T + + +K+ QE EE + + ++
Sbjct: 150 KHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLS-- 207
Query: 447 RQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDL 486
Q EQA Q EK+++ ++ + +ELL + D+
Sbjct: 208 -QTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADV 246
Score = 42.0 bits (97), Expect = 0.001
Identities = 75/356 (21%), Positives = 148/356 (41%), Gaps = 58/356 (16%)
Query: 151 ELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVN 210
EL + K K + + QLK+ + L+ + S E +L + L+Q+L++
Sbjct: 2753 ELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLS 2812
Query: 211 LRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRD--- 267
+L+ S+ +LE + N++Q+ +A Q E+ N L++F E K R
Sbjct: 2813 KDEQLLHLSS---QLEDSYNQVQSFSKAMASL-QNERDHLWNELEKFRKSEEGKQRSAAQ 2868
Query: 268 -----TYIEEAEKYKMQLQEQFD-------NLNAAHETSKLEIEASHSEKLELLK----- 310
++ +K LQ D NL + EI H K +L +
Sbjct: 2869 PSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKT 2928
Query: 311 KAYEASLSEIKK-----GHEIEKKSLED----------------LLSEKQES---LEKQI 346
KA++ E+++ HE+ + +E +S+K + L+ I
Sbjct: 2929 KAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLI 2988
Query: 347 NDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDI 406
+L+S + + + LK + Q R+A + + L E E L+ L +++HQ+++
Sbjct: 2989 RELRS-SSSQTQPLKVQYQ-RQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL 3046
Query: 407 KLMKM-----EKLVDNNTALVDKLKRFQ--QENEELKARMDKHMAI-SRQLSTEQA 454
++ ++ + L + NT + Q +EN++ + H A+ +Q+ QA
Sbjct: 3047 RIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQA 3102
Score = 41.6 bits (96), Expect = 0.002
Identities = 42/201 (20%), Positives = 89/201 (44%), Gaps = 2/201 (0%)
Query: 279 QLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEK-KSLEDLLSE 337
Q++ Q + A +L++ ++ SE + ++ ++ K+G EIE K++
Sbjct: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEV 1365
Query: 338 KQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVL-EI 396
ESL++++ + + L + + + ++ + K + YL +L +A L +I
Sbjct: 1366 HAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKI 1425
Query: 397 KNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVL 456
+ E + Q+D+ +L +++K+ Q E E+K + ++ SR Q L
Sbjct: 1426 QTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKL 1485
Query: 457 QESLEKESKVNKRLSMENEEL 477
Q +L + K EEL
Sbjct: 1486 QAALISRKEALKENKSLQEEL 1506
Score = 38.9 bits (89), Expect = 0.011
Identities = 55/236 (23%), Positives = 102/236 (43%), Gaps = 22/236 (9%)
Query: 148 KTLELTQYKTKCENQSGFIL--QLKQLLACGNTKFEALTVVIQH--LLSEREEALKQHKT 203
+ ++L Q + Q IL QL+Q+ A NT + + +L E+ E +
Sbjct: 273 QVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332
Query: 204 LSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYT--RE 261
LS NL+ E+ E+ +A+ EL++ Y A Q+H+AE E+ + + +E
Sbjct: 333 LSFH--NLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQE 390
Query: 262 YEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEK-----LELLKKAYEAS 316
+ D ++ K EQ + +A +LE + K L L +
Sbjct: 391 LQSACDALKDQNSKLLQDKNEQ--AVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHET 448
Query: 317 LSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDAL------NEKLKSEEQK 366
S+ ++ + + + E SL+K++ +L++E AL E+LK+E +K
Sbjct: 449 ASQ-TSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEK 503
Score = 38.9 bits (89), Expect = 0.011
Identities = 70/313 (22%), Positives = 126/313 (40%), Gaps = 52/313 (16%)
Query: 199 KQHKTLSQELVN--LRGELVTASTTC---------------EKLEKARNELQTVYEAFVQ 241
KQ K L E N LR E+ A T E+LE+ + E +T+ + F Q
Sbjct: 1685 KQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKF-Q 1743
Query: 242 QHQAEKTERENRLKEF-YTREYEKLRDTYIEEAEKYKMQLQ------EQFDNLNAAHETS 294
+EK +++ + E + +E EK+ Q + ++
Sbjct: 1744 SLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSL 1803
Query: 295 KLEIEASHSEKLELLKKAYEASLSEIKKGHEIE---------KKSLEDLLSEKQ------ 339
+ + SE + K A A + EI K+ + L EKQ
Sbjct: 1804 SMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFS 1863
Query: 340 ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNE 399
++LE + N L S+ + +LK +++ K NL N QI ++EL + + E E
Sbjct: 1864 QTLENEKNTLLSQISTKDGELKMLQEE---VTKMNLLNQQI---QEELSRVTKLKETAEE 1917
Query: 400 KLHQQDIKLMKMEKLVDNNTAL---VDKLKRFQQENEELKARMDKHMAISRQLSTE-QAV 455
+ + D++ M +L + N ++ + Q +NE L++ M +L E Q +
Sbjct: 1918 E--KDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQL 1975
Query: 456 LQESLEKESKVNK 468
++E + ES++ K
Sbjct: 1976 VKEKTKVESEIRK 1988
Score = 38.9 bits (89), Expect = 0.011
Identities = 70/350 (20%), Positives = 144/350 (41%), Gaps = 34/350 (9%)
Query: 168 QLKQLLACG---NTKFEALTVVIQHLLSEREEA----LKQHKTLSQELVNLRGELVTAST 220
Q KQLL N + E ++ L E EEA + L +E +L E+ +
Sbjct: 2550 QQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKV 2609
Query: 221 TCEKLEKARNELQTVYEAFVQQHQAEKTERE-NRLKEFYTREYEKLRDTYIE------EA 273
+ +L + LQ + Q + E E +RL ++ +++ + E EA
Sbjct: 2610 SISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEA 2669
Query: 274 EK----YKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEAS-----LSEIKKGH 324
K + +L+++ +L+ + E E + EL + E +++ KG
Sbjct: 2670 AKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGL 2729
Query: 325 EIEKKSLEDLLSEKQESLE---KQINDLKSENDA-LNEKLKSEEQKRRAREKANLKNPQI 380
+ +S +S Q S + +++++LK + DA L E + +EQ RE+ L +
Sbjct: 2730 TAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETA 2789
Query: 381 MYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKR----FQQENEELK 436
+ E+ + LE N++L +D +L+ + ++++ V + Q E + L
Sbjct: 2790 FSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLW 2849
Query: 437 ARMDKHMAI---SRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHN 483
++K ++ + + + ++ K L + + LL +L N
Sbjct: 2850 NELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKN 2899
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 76.6 bits (187), Expect = 5e-14
Identities = 84/352 (23%), Positives = 156/352 (44%), Gaps = 34/352 (9%)
Query: 147 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 206
EK EL Q+K + + + ++ + + + IQ ++ E+EE + + L
Sbjct: 1545 EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQI 1604
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTR------ 260
E L+ T + E E Q + V + Q + E E+ ++F T+
Sbjct: 1605 ERDQLKEN--TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN 1662
Query: 261 -EYEKLRDTYI--EEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASL 317
E E +R T I E E+ + +E+ D+L + ET K+E + E + + E
Sbjct: 1663 IETENIRLTQILHENLEEMRSVTKER-DDLRSVEETLKVERDQLKENLRETITRDLEKQ- 1720
Query: 318 SEIK------KGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALN-EKLKSEEQKRRAR 370
E+K K H+ L ++SEK + DL+ NDAL + LK +E+ R A
Sbjct: 1721 EELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAH 1780
Query: 371 EKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQ 430
M+L+++ E++ + I +EK KL M+K ++N+ A + + + +
Sbjct: 1781 ----------MHLKEQQETIDKLRGIVSEKTD----KLSNMQKDLENSNAKLQEKIQELK 1826
Query: 431 ENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLH 482
NE + K + +++ +E L++ ++ +S +L +EN L KLH
Sbjct: 1827 ANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLH 1878
Score = 63.2 bits (152), Expect = 6e-10
Identities = 75/333 (22%), Positives = 152/333 (45%), Gaps = 32/333 (9%)
Query: 169 LKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ---ELVNLRGELVTASTTCEKL 225
L++ + K E L +V HL +E K +S+ E+ N++ +L ++ +
Sbjct: 1709 LRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768
Query: 226 E-KARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQF 284
+ K + EL+ + H E+ E ++L+ + + +KL + ++ E +LQE+
Sbjct: 1769 DLKIQEELRIAH-----MHLKEQQETIDKLRGIVSEKTDKLSNMQ-KDLENSNAKLQEKI 1822
Query: 285 DNLNA-AHETSKLEIEASHSEK----LELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQ 339
L A H+ L+ + + ++K +E LKK + + K EIE +L L E
Sbjct: 1823 QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSK-LEIENLNLAQKLHENL 1881
Query: 340 ESLEKQIND----------LKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELES 389
E ++ + + LK E D L E L+ E + R + LK +++ E
Sbjct: 1882 EEMKSVMKERDNLRRVEETLKLERDQLKESLQ-ETKARDLEIQQELKTARMLSKEH---- 1936
Query: 390 LKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQL 449
K ++ EK+ ++ I++ ++K +D + + K + Q+ E R+ + + +S +
Sbjct: 1937 -KETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKK 1995
Query: 450 STEQAVLQESLEKESKVNKRLSMENEELLWKLH 482
E L++ E ++ + + M+N +L KLH
Sbjct: 1996 INEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLH 2028
Score = 60.1 bits (144), Expect = 5e-09
Identities = 73/321 (22%), Positives = 143/321 (44%), Gaps = 45/321 (14%)
Query: 188 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 247
Q LL+ +EE + K ++ E+ NL+ EL T E +E R EL ++ ++
Sbjct: 1141 QQLLNVQEEMSEMQKKIN-EIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199
Query: 248 TERE--NRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEK 305
ER+ L++ + E + LR YI E E +Q +E+ L AH K H E
Sbjct: 1200 KERKVLKELQKSFETERDHLRG-YIREIEATGLQTKEE---LKIAHIHLK-----EHQET 1250
Query: 306 LELLKKAYEASLSEIKKGHEIEKKSLE-----DLLSEKQESLEKQINDLKSENDALNE-- 358
++ L+++ ++I ++EK + +L E+QE L + ++ + +NE
Sbjct: 1251 IDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELL-PNVKEVSETQETMNELE 1309
Query: 359 -------------KLKSEEQKRRAREKANLKNPQIMYLEQELESLKAV---LEIKNEKLH 402
+ E ++ R EK +I L +E ++LK + LE+K+++L
Sbjct: 1310 LLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLK 1369
Query: 403 QQDIKLMKMEKLVDNNTALVDKLKRFQQENE------ELKARMDKHMAISRQLSTEQAVL 456
+ + + K+ ++ + L +++NE E++ K A+ R + E L
Sbjct: 1370 EHIRE--TLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLR-IEIEMLGL 1426
Query: 457 QESLEKESKVNKRLSMENEEL 477
+ L++ K ++ E ++L
Sbjct: 1427 SKRLQESHDEMKSVAKEKDDL 1447
Score = 52.4 bits (124), Expect = 1e-06
Identities = 81/384 (21%), Positives = 177/384 (46%), Gaps = 52/384 (13%)
Query: 149 TLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ-- 206
T +L + TK + + + + ++LL E + + L + K TL++
Sbjct: 1268 TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIE 1327
Query: 207 -ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQH-QAEKTEREN--RLKEFYTREY 262
E + L + + + L K R+ L+T+ EA +H Q ++ RE +++E +++
Sbjct: 1328 MERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387
Query: 263 EKLR--------DTYIEEAEKYK------MQLQEQFDNLNAAHETSKLEIEASHSEK--L 306
+ L + E E++K ++++ + L+ + S E+++ EK L
Sbjct: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1447
Query: 307 ELLKKAYEASLSEIKKG-HEIEKKSLED---------LLSEKQESL----------EKQI 346
+ L++ ++ ++K+ EI K LE L E++E++ E +I
Sbjct: 1448 QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI 1507
Query: 347 NDLKSENDALNEKLKSEEQK-RRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQD 405
+ ++ + +A+N+KL+++ Q+ E+ N+K QI +++++ LK E + K
Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEKEEQFNIK--QISEVQEKVNELKQFKEHRKAKDSALQ 1565
Query: 406 IKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQ-----AVLQESL 460
KM +L + ++++ +E EE+K R+ + + I R E A ++ES
Sbjct: 1566 SIESKMLELTNRLQESQEEIQIMIKEKEEMK-RVQEALQIERDQLKENTKEIVAKMKESQ 1624
Query: 461 EKESKVNKRLSM-ENEELLWKLHN 483
EKE + K ++ E +E + ++ +
Sbjct: 1625 EKEYQFLKMTAVNETQEKMCEIEH 1648
Score = 51.2 bits (121), Expect = 2e-06
Identities = 79/296 (26%), Positives = 137/296 (46%), Gaps = 44/296 (14%)
Query: 190 LLSEREEALK--QHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 247
LL E+E+ +K Q SQ+L N++ +L S + E +E + QT+++A A+
Sbjct: 583 LLREKEDQIKKLQEYIDSQKLENIKMDL---SYSLESIEDPKQMKQTLFDAETVALDAK- 638
Query: 248 TERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE 307
RE LR +E EK K +L + + + + ++EA +++
Sbjct: 639 ------------RESAFLRSENLELKEKMK-ELATTYKQMENDIQLYQSQLEAKKKMQVD 685
Query: 308 LLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKR 367
L K+ A K I+ K +DLL + LE +I DL+ E LN+++ E+
Sbjct: 686 LEKELQSAFNEITKLTSLIDGKVPKDLLCNLE--LEGKITDLQKE---LNKEV---EENE 737
Query: 368 RAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKR 427
RE+ L + ++ L E+E L+ ++ K+E+LH I + +KL + +V K R
Sbjct: 738 ALREEVILLS-ELKSLPSEVERLRKEIQDKSEELH---IITSEKDKLF---SEVVHKESR 790
Query: 428 FQQENEEL-KARMDKHMAISRQLSTEQ-----AVLQESLEKESKV----NKRLSME 473
Q EE+ K + D S ST+Q L E++ K+ N+R++ E
Sbjct: 791 VQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQE 846
Score = 51.2 bits (121), Expect = 2e-06
Identities = 86/363 (23%), Positives = 154/363 (42%), Gaps = 62/363 (17%)
Query: 147 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVI---QHLLSEREEALKQHKT 203
EKT +L+ + EN + + + Q L + L + Q +SE E+ KQ K
Sbjct: 1799 EKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKD 1858
Query: 204 LSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYE 263
S L L E + + +KL + E+++V + + E+T + R + + +
Sbjct: 1859 QSLTLSKLEIENLNLA---QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQET 1915
Query: 264 KLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEK---LELLKKAYEASLSEI 320
K RD I++ K L ++ H+ + ++ SEK + ++K + S E+
Sbjct: 1916 KARDLEIQQELKTARMLSKE-------HKETVDKLREKISEKTIQISDIQKDLDKSKDEL 1968
Query: 321 -KKGHEIEKKSLEDL-------LSEKQ----ESLEKQ-------INDLKSENDALNEKL- 360
KK E++KK L+ L +S K+ E L+KQ + ++ +N L +KL
Sbjct: 1969 QKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLH 2028
Query: 361 ----------KSEEQKRRAREKANLKNPQ-IMYLEQELESLKAVLEIKNEKLHQQDIKLM 409
K ++ RR +E ++ Q I L + + + ++K EK D +
Sbjct: 2029 ESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQH 2088
Query: 410 KMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKR 469
E L + + + + LKR+ + MD H +LS + LEKE + K
Sbjct: 2089 LTESLREKCSRIKELLKRYSE--------MDDHYECLNRLSLD-------LEKEIEFQKE 2133
Query: 470 LSM 472
LSM
Sbjct: 2134 LSM 2136
Score = 48.9 bits (115), Expect = 1e-05
Identities = 75/351 (21%), Positives = 147/351 (41%), Gaps = 41/351 (11%)
Query: 179 KFEALTVVIQHLLSEREEALKQHKTLS-QELVNLRGELVTASTTCEKLEKARNELQTVYE 237
K + L + IQHL + + ++ + L + ++L E + + + + E Q V
Sbjct: 2204 KQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVL- 2262
Query: 238 AFVQQHQAEKTERENRLKEFYTREY--EKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSK 295
+ + E L+E+ + EKL++ +E ++ Q+ F+N A
Sbjct: 2263 -------SNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRI-CQVNNFFNNRIIAIMNES 2314
Query: 296 LEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSEN-- 353
E E E+ + K +E L +K+ +E K+ + L + Q+N +N
Sbjct: 2315 TEFE----ERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGA--QVNPTTQDNKN 2368
Query: 354 --------DALNEKLKS-EEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQ 404
EK++ E A+E A K +I+ +++ELE ++ K+H+
Sbjct: 2369 PHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHES 2428
Query: 405 DIKLMKMEKLVDNNTALVDKL----KRFQQENEELKARMDK----HMAISRQLSTEQAVL 456
+ L K ++ + L DK+ K +++E E+LK ++ K M +++ E +
Sbjct: 2429 NKCLEKTKETIQ---VLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISAT 2485
Query: 457 QESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSG 507
+ ++E + +V RL EN + + + S P S PL SG
Sbjct: 2486 KATVEYQKEV-IRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSG 2535
Score = 48.5 bits (114), Expect = 1e-05
Identities = 83/364 (22%), Positives = 170/364 (46%), Gaps = 57/364 (15%)
Query: 148 KTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQE 207
KT EL + + + + + QLK+ L ++ + + + + ++ L++ KTL+QE
Sbjct: 871 KTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE 930
Query: 208 LVNL----------RGELV-----TASTTCEKLEKARNELQTVYEAFVQQHQAEKTEREN 252
+L R +L T + + E+ RN L++ ++QHQ E N
Sbjct: 931 KDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES-----LKQHQ----ETIN 981
Query: 253 RLKEFYTREYEKLRDTYIEE-AEKYKMQLQEQFDNLN-----AAHETSKLEIEASHSEKL 306
LK + E R+ ++EE + K + Q++ ++ A T L + +E +
Sbjct: 982 TLKSKISEEVS--RNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039
Query: 307 ELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQ-------ESLEKQINDLKSENDALNEK 359
E +K + S I++ +E++ + LE +++EK+ E++E I + + E L ++
Sbjct: 1040 EQQRKIF----SLIQEKNELQ-QMLESVIAEKEQLKTDLKENIEMTIEN-QEELRLLGDE 1093
Query: 360 LKSEEQKRRAREK--ANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDN 417
LK ++Q+ A+EK A K ++ L ++ L+ K+++L ++ +L+ +++ +
Sbjct: 1094 LK-KQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSE 1152
Query: 418 NTALVDKLKRFQQE--NEELKARMDKHMAISR----QLSTEQAVLQESLEKESKVNKRLS 471
+++++ + E N+EL +HM R Q E +S+ KE KV K L
Sbjct: 1153 MQKKINEIENLKNELKNKELTL---EHMETERLELAQKLNENYEEVKSITKERKVLKELQ 1209
Query: 472 MENE 475
E
Sbjct: 1210 KSFE 1213
Score = 45.4 bits (106), Expect = 1e-04
Identities = 73/328 (22%), Positives = 136/328 (41%), Gaps = 47/328 (14%)
Query: 223 EKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREY----EKLRD--TYIEEAEKY 276
EK EK QT+ + Q T ++N+ +R EK+R+ + EA++
Sbjct: 2337 EKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKES 2396
Query: 277 KMQLQEQFDNLNAAHETS-----KLEIEASHSEK-LELLKKAYEASLSEIKKGHEIEKKS 330
M + + + E + KL+ + S K LE K+ + ++ G + K+
Sbjct: 2397 AMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEE 2456
Query: 331 LEDLLSEKQE-SLEKQINDLKSENDALNEKLKSEEQKRRARE-KANLKNPQIMYLEQELE 388
+EDL + + LEK N + E + K E QK R + NL+ Q+ +
Sbjct: 2457 IEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRR------SQQAQ 2510
Query: 389 SLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDK---------LKRFQQENEELKARM 439
+ E + + + + +V N AL+ K + + +Q+NE+L +
Sbjct: 2511 DTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQK 2570
Query: 440 DKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSS--- 496
++ ++ ++ LS E +E K + +K+++ EN K+ S K+ T S
Sbjct: 2571 NELLSNNQHLSNEVKTWKERTLKR-EAHKQVTCENSPKSPKVTG--TASKKKQITPSQCK 2627
Query: 497 ------AIPLQSPRN------SGSFPSP 512
+P +SP++ S S PSP
Sbjct: 2628 ERNLQDPVPKESPKSCFFDSRSKSLPSP 2655
>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
Length = 872
Score = 76.6 bits (187), Expect = 5e-14
Identities = 83/351 (23%), Positives = 161/351 (45%), Gaps = 41/351 (11%)
Query: 187 IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAE 246
I+ LL +EE K+ L E+V LR L + ++ E+++ E + F Q+ Q
Sbjct: 148 IRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETERSKEEAEHAISQFQQEIQQR 207
Query: 247 KTE--RENRLKEFYTREYEKLR-------------DTYIEEAEKYKMQLQEQFDNLNAAH 291
+ E RE R KE +E ++++ Y++++++ +L++Q +
Sbjct: 208 QNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEELQKLEQQLKEQKILN 267
Query: 292 ETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEK---QIND 348
E + E+E +L ++ + SL + E ++K+LE L K+E + + I
Sbjct: 268 ERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQKALE--LKAKEEEVHQMRLDIGK 325
Query: 349 LKSENDALNEKL-KSEEQKRRARE-KANLKNPQIMYLEQELESLKAVLEI----KNEKLH 402
L + +++KL +E+QK + K LKN QI+ LE+E+E+ K E+ +E L
Sbjct: 326 LNKIREQIHKKLHHTEDQKAEVEQHKETLKN-QIVGLEREVEASKKQAELDRKAMDELLR 384
Query: 403 QQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEK 462
++DI M K V+ D +K +Q L+ + + + + +Q + LEK
Sbjct: 385 ERDILNKNMLKAVNATQKQTDLVKLHEQAKRNLEGEIQNY----KDEAQKQRKIIFHLEK 440
Query: 463 E--------SKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRN 505
E S + +++ M E++ K+ + ++ S I L+ +N
Sbjct: 441 ERDRYINQASDLTQKVLMNMEDI--KVRETQIFDYRKKIAESEIKLKQQQN 489
Score = 45.4 bits (106), Expect = 1e-04
Identities = 55/297 (18%), Positives = 129/297 (43%), Gaps = 51/297 (17%)
Query: 226 EKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 285
E A E++ ++ + + +K+ + R++ Y R + ++ +Y + EK M + +
Sbjct: 13 ESAFEEMERDFQGVLHELSGDKSLEKFRIE--YERLHAVMKKSY--DNEKRLMAKCRELN 68
Query: 286 N---LNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESL 342
+N+A + L++ + LKK E + + ++ E+K+ E +L+ K+E +
Sbjct: 69 AEIVVNSAKVATALKLSQDDQTTIASLKKEIEKAWKMVDSAYDKEQKAKETILALKEEIV 128
Query: 343 E----------------KQINDL--------KSENDALNEKLK--------SEEQKRRAR 370
I DL K + L+E +K +E+Q+ R
Sbjct: 129 NLTKLVEQGSGLSMDQHSNIRDLLRFKEEVTKERDQLLSEVVKLRESLAQTTEQQQETER 188
Query: 371 EKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQ 430
K ++ I +QE++ + + K + + +L +++ +D+ + L+++ Q
Sbjct: 189 SKEEAEHA-ISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQ 247
Query: 431 ENEELKARMDKHMAISR-----------QLSTEQAVLQESLEKESKVNKRLSMENEE 476
+++E ++++ + + Q A LQ+ E+ S V ++LS EN++
Sbjct: 248 KSKEELQKLEQQLKEQKILNERAAKELEQFQMRNAKLQQENEQHSLVCEQLSQENQQ 304
Score = 40.4 bits (93), Expect = 0.004
Identities = 57/263 (21%), Positives = 104/263 (39%), Gaps = 34/263 (12%)
Query: 187 IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAE 246
+ ++SER+ Q + EL L ++ + K E N Q + + + + + +
Sbjct: 603 LDQVISERDILGSQLVRRNDELALLYEKIKIQQSVLNKGESQYN--QRLEDMRILRLEIK 660
Query: 247 KTERENRLKEFYTREYEKLRDTYIEEAEKYKMQ------LQEQFDNLNAAHETSKLEIEA 300
K RE + E+LR + + + L+E+ +N H KLE A
Sbjct: 661 KLRREKGILARSMANVEELRQEFFHMQRELLKERTRCRALEEELENPLNVHRWRKLE--A 718
Query: 301 SHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKL 360
S EL++K + I K E+ +K L LL EK EKL
Sbjct: 719 SDPNAYELIQKIHTLQKRLISKTEEVVEKEL--LLQEK-------------------EKL 757
Query: 361 KSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTA 420
E + AR+ Q+ + L K L++ + +L+ +++ + + V+ T
Sbjct: 758 YMELKHVLARQPGPEAAEQLKLYRRTLHDKKQQLKVLSSELNMYEVQSKEYKYEVEKLTN 817
Query: 421 LVDKLKR---FQQENEELKARMD 440
+ LK+ Q+ E+L+ D
Sbjct: 818 ELQNLKKKYLAQKRKEQLQKNKD 840
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 74.3 bits (181), Expect = 2e-13
Identities = 90/410 (21%), Positives = 187/410 (45%), Gaps = 61/410 (14%)
Query: 112 RKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKC------------ 159
+ +L NA EK+R +N ++L IQ + E+ K KC
Sbjct: 858 QSDLLEMKNANEKTRLEN-QNLLIQVEEVSQTCSKS---EIHNEKEKCFIKEHENLKPLL 913
Query: 160 ------ENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRG 213
+ ++ IL L + K + L+ V + L E+ E L++ +E +N +
Sbjct: 914 EQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKE--LEEKIENLEKECKEKEEKIN-KI 970
Query: 214 ELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFY--TREYEKLRDTYIE 271
+LV E L+ +R E QTV E ++ ++EK + +++ Y+ L Y +
Sbjct: 971 KLVAVKAKKE-LDSSRKETQTVKEE-LESLRSEKDQLSASMRDLIQGAESYKNLLLEYEK 1028
Query: 272 EAEKYKMQ------LQEQFDNLNAAHETSKLEIEASHSEKLELLK---------KAYEAS 316
++E+ ++ + + ++L S L+ E +S+ +LL K E
Sbjct: 1029 QSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQ 1088
Query: 317 LSEIKKGHEIEKKSLEDLLSEKQESLEKQ---INDLKS-------ENDALNEKLKSEEQK 366
+ E+++ + K LE +K++ +++ +N+L+ E L + ++ E
Sbjct: 1089 ILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELV 1148
Query: 367 RRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLH--QQDIKLMKM--EKLVDNNTALV 422
++ ++ L N +I E+ ++ L L KN K+ +Q+IK+ K E L + T+L
Sbjct: 1149 KKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQ 1208
Query: 423 DKLKRFQQENEELK---ARMDKHMAISRQLSTEQAVLQESLEKESKVNKR 469
+++++++N ++K + K +A S+Q T+ +LQ SL+ E + +++
Sbjct: 1209 SSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQ 1258
Score = 67.4 bits (163), Expect = 3e-11
Identities = 84/381 (22%), Positives = 167/381 (43%), Gaps = 61/381 (16%)
Query: 154 QYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKT---LSQELVN 210
++++ + Q+ + +L+Q L T+ +AL + L E E+ L Q + L + N
Sbjct: 504 EFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKN 563
Query: 211 LRGE-------LVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYE 263
L+ + L T ++LE N L + F+ + + E +N K+ E
Sbjct: 564 LQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERL 623
Query: 264 KLR-DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE-------LLKKAYEA 315
L +E+ +Y +L+++ + L E + L+ + + +KLE +L + E
Sbjct: 624 ILELGKKVEQTIQYNSELEQKVNELTGGLEET-LKEKDQNDQKLEKLMVQMKVLSEDKEV 682
Query: 316 SLSEIKKGHEIEKK----------SLEDLLSEKQE--------SLEKQINDLKSENDALN 357
+E+K +E K LE LS+K++ LEK++ + E D LN
Sbjct: 683 LSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLN 742
Query: 358 EKLKSEEQKR----------------RAREKANLKNPQIMYLEQELESLKAVLEIKNEKL 401
+ L++E+ ++ E + K+ + L+ ESL + E K
Sbjct: 743 KLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKD-VVNVLQAVGESLAKINEEKCNLA 801
Query: 402 HQQDIKLMKMEK----LVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQ 457
Q+D K++++EK L + + ++LK ++ E+ K + K + ++ +E+ LQ
Sbjct: 802 FQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKEL---EEIQSEKEALQ 858
Query: 458 ESLEKESKVNKRLSMENEELL 478
L + N++ +EN+ LL
Sbjct: 859 SDLLEMKNANEKTRLENQNLL 879
Score = 63.9 bits (154), Expect = 3e-10
Identities = 84/370 (22%), Positives = 166/370 (44%), Gaps = 42/370 (11%)
Query: 132 SLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLL 191
S+ +Q T + + EK L + E+Q + ++ N K + L + QH+
Sbjct: 317 SILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKD--EVTYMNNLKLK-LEMDAQHI- 372
Query: 192 SEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAF---VQQHQAEKT 248
++E + + L ++ L L C +EK ++EL + + F V+QH E
Sbjct: 373 --KDEFFHEREDLEFKINELL--LAKEEQGCV-IEKLKSELAGLNKQFCYTVEQHNREVQ 427
Query: 249 ERENRLKEFYTREYEKLRDTYIEEAEKYKMQ-------LQEQFDNLNAAHETSKLEIEAS 301
LKE + +E +L +T++ ++EK K+ L+EQ +NL + + L E S
Sbjct: 428 S----LKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYE-S 482
Query: 302 HSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNE--- 358
E +E+L+ S +I + E +S++ + L++++ +E DAL E
Sbjct: 483 LREIMEILQTELGESAGKISQ----EFESMKQQQASDVHELQQKLRTAFTEKDALLETVN 538
Query: 359 KLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKME----KL 414
+L+ E +K ++++ + LE +++L+ + L Q+D L ++E L
Sbjct: 539 RLQGENEKLLSQQEL------VPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSL 592
Query: 415 VDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE-QAVLQESLEKESKVNKRLSME 473
+ ++KLK +E + + ++ + +L + + +Q + E E KVN+
Sbjct: 593 TEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGL 652
Query: 474 NEELLWKLHN 483
E L K N
Sbjct: 653 EETLKEKDQN 662
Score = 54.3 bits (129), Expect = 3e-07
Identities = 83/353 (23%), Positives = 153/353 (43%), Gaps = 46/353 (13%)
Query: 160 ENQSGFILQLKQLLACGNTKFEALTVVIQH---LLSEREEALKQHKTLSQ--------EL 208
E Q I +LK LA N +F V QH + S +E+ K+ L++ E
Sbjct: 395 EEQGCVIEKLKSELAGLNKQF--CYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEK 452
Query: 209 VNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDT 268
+ L E+ CE L++ + E YE+ + + +TE + ++E+E ++
Sbjct: 453 LTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKI-SQEFESMKQQ 511
Query: 269 YIEEAEKYKMQLQEQFDNLNAAHET-SKLEIEASHSEKLELLKKAYEASLSEIKKGHEIE 327
+ + + +L+ F +A ET ++L+ E + L E ++ +++ + +
Sbjct: 512 QASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVY 571
Query: 328 KKSLEDLLSEKQESLEKQINDLKSENDALNEKLKS------------EEQKRRAREKANL 375
SL + +E LE +IN L E D KLK+ E ++R E
Sbjct: 572 LLSLSQRDTMLKE-LEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKK 630
Query: 376 KNPQIMY---LEQELESLKAVLEIKNEKLHQQDIKLMKMEKLV-------DNNTALVDKL 425
I Y LEQ++ L LE E L ++D K+EKL+ ++ L ++
Sbjct: 631 VEQTIQYNSELEQKVNELTGGLE---ETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEV 687
Query: 426 KRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKE--SKVNKRLSMENEE 476
K +EN +L + + +SR L + ++ + KE +++ K+L + EE
Sbjct: 688 KSLYEENNKLSSEKKQ---LSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEE 737
Score = 49.3 bits (116), Expect = 8e-06
Identities = 78/367 (21%), Positives = 153/367 (41%), Gaps = 65/367 (17%)
Query: 181 EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFV 240
+ALT + LL E+ E +Q +L +E + ++ E+ + T K+ A EL+ + +V
Sbjct: 72 KALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVT---KMGDAHKELEQSHINYV 128
Query: 241 QQHQAEKTE------RENRLKEFYTREYEKLRDTYIEEAEKYKMQ---------LQEQFD 285
++ + K E + + K ++ E+ +T +E +E+ K Q LQE+ +
Sbjct: 129 KEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIE 188
Query: 286 NLNAAHETSKL----EIEASHSEKLELLKK-----------------AYEASLSEIKKGH 324
+ E L +++A+ EK E + + + + L ++K H
Sbjct: 189 KIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIH 248
Query: 325 EIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQK------------RRAREK 372
+ E K L + + E +IN L + L ++ ++ E+ R+A
Sbjct: 249 QEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSN 308
Query: 373 ANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLK-RFQQE 431
AN N L QE ++ V+ K + L +L ++ + ++ LK + + +
Sbjct: 309 ANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMD 368
Query: 432 NEELK-----ARMDKHMAISRQL--STEQAVLQESLEKE-SKVNKRLSMENEELLWKLHN 483
+ +K R D I+ L EQ + E L+ E + +NK+ E+ HN
Sbjct: 369 AQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQ-----HN 423
Query: 484 GDLCSPK 490
++ S K
Sbjct: 424 REVQSLK 430
Score = 45.1 bits (105), Expect = 2e-04
Identities = 72/326 (22%), Positives = 129/326 (39%), Gaps = 39/326 (11%)
Query: 177 NTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCE----KLEKARNEL 232
NTK + L V + L++ ++A H L +L+GEL + E +L + +E
Sbjct: 1218 NTKIKQLLVKTKKELADSKQAETDHLILQ---ASLKGELEASQQQVEVYKIQLAEITSEK 1274
Query: 233 QTVYEAF---VQQHQAEKTERENRLKEFYT--REYEKLRDTYIEEAEKYKMQ----LQEQ 283
++E +QHQ + + R+ R + + T E E YK++ L++Q
Sbjct: 1275 HKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQ 1334
Query: 284 FDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLE 343
+ + ET + E H LE+L + L + + +I L+ L SE LE
Sbjct: 1335 KNKSMSQAETEGAKQEREH---LEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLE 1391
Query: 344 ---KQINDLKSENDALNEKL----------KSEEQK---RRAREKANLKN---PQIMYLE 384
K + + S+ L EKL KSE + + + L+N Q+ +L+
Sbjct: 1392 RHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQ 1451
Query: 385 QELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMA 444
+E L+ + K+ Q +L K E + + LK ++ +D H
Sbjct: 1452 EEHRKTVETLQQQLSKMEAQLFQL-KNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTV 1510
Query: 445 ISRQLSTEQAVLQESLEKESKVNKRL 470
+ + ES+ S + L
Sbjct: 1511 TREEGEGMETTDTESVSSASTYTQSL 1536
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 73.9 bits (180), Expect = 3e-13
Identities = 55/299 (18%), Positives = 146/299 (48%), Gaps = 19/299 (6%)
Query: 188 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 247
+ ++ E+EE +++ + + E L EK EK R + ++E + Q EK
Sbjct: 341 EEMMWEKEEKMRRQEEMMWEKEEKMRRL--EEMMWEKEEKIRELEEKMHEQEKIREQEEK 398
Query: 248 TERENRLKEFYTREYEKLR-----DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASH 302
+ E +++E R+ ++ + + E+ EK + Q ++ + HE K+ E
Sbjct: 399 RQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 458
Query: 303 SEKLELLKKAYEASLSEIKKGHEI----EKKSLEDLLSEKQESLEKQINDLKSENDALNE 358
E+ E+ ++ +I++ EI EK ++ + +++E + +Q + + + + E
Sbjct: 459 QEQEEMWRQE-----EKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIRE 513
Query: 359 KLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNN 418
+ EE+ R EK + +I E+++ + +++ + EK+ +Q+ K+ + EK+
Sbjct: 514 Q---EEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE 570
Query: 419 TALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 477
+ ++ ++ +++ E+++ + +K ++ ++ ++QE EK + +++ + E++
Sbjct: 571 EKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 629
Score = 68.2 bits (165), Expect = 2e-11
Identities = 65/296 (21%), Positives = 135/296 (45%), Gaps = 21/296 (7%)
Query: 191 LSEREEALKQH--KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKT 248
+ E+EE +++ K QE R E EK EK R + + ++E + + E+
Sbjct: 316 IQEQEEKIREQEEKIREQEEKMRRQE----EMMWEKEEKMRRQEEMMWEKEEKMRRLEEM 371
Query: 249 --ERENRLKEFYTR--EYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSE 304
E+E +++E + E EK+R+ + E+ K++ QE+ A + +I +
Sbjct: 372 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 431
Query: 305 KLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEE 364
E KK + +K HE EK E+ E QE + +Q ++ + + +K K E
Sbjct: 432 IREQEKKMWRQE----EKIHEQEKIREEEKRQE-QEEMWRQEEKIREQEEIWRQKEKMHE 486
Query: 365 QKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDK 424
Q EK + ++ E+++ + + + EK+ +Q+ K+ + E+ + + +
Sbjct: 487 Q-----EKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIRE 541
Query: 425 LKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWK 480
+ QE EE ++ M ++ ++ ++E EK + +++ E EE +W+
Sbjct: 542 QEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKI-REQEEKIWE 596
Score = 60.1 bits (144), Expect = 5e-09
Identities = 65/306 (21%), Positives = 142/306 (46%), Gaps = 27/306 (8%)
Query: 187 IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAE 246
+Q + SE+ E K L ++L + L E + ELQ+V Q Q E
Sbjct: 230 LQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEA-DHLGKELQSVSAKL--QAQVE 286
Query: 247 KTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKL 306
+ E NRL + + E+ E+ ++++ ++QEQ + + E + + E ++
Sbjct: 287 ENELWNRLNQ----QQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEE 342
Query: 307 ELLKKAYEASLSEIKKGHEIEK-KSLEDLLSEKQESLEKQINDLKSENDAL--NEKLKSE 363
+ +K + E + EK + LE+++ EK+E + +++ + E + + E+ + E
Sbjct: 343 MMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKI-RELEEKMHEQEKIREQEEKRQE 401
Query: 364 EQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVD 423
E+K R +EK + ++ E+++ + EK+ +Q+ K+ + E+ + + +
Sbjct: 402 EEKIREQEKRQEQEAKMWRQEEKIRE-------QEEKIREQEKKMWRQEEKIHEQEKIRE 454
Query: 424 KLKRFQQE---NEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLS------MEN 474
+ KR +QE +E K R + + ++ EQ +++ EK + +++ E
Sbjct: 455 EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQ 514
Query: 475 EELLWK 480
EE +W+
Sbjct: 515 EEKMWR 520
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 73.2 bits (178), Expect = 5e-13
Identities = 78/302 (25%), Positives = 135/302 (44%), Gaps = 39/302 (12%)
Query: 188 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 247
+ L+ RE+ L L+ E+ L+ +L+ ++ +A EL E + A+K
Sbjct: 852 EELVKVREKQLAAENRLT-EMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKK 910
Query: 248 TERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE 307
E E + R E+ +AEK KMQ N+ E +LE E S +KL+
Sbjct: 911 QELEEICHDLEARVEEEEERCQHLQAEKKKMQ-----QNIQELEE--QLEEEESARQKLQ 963
Query: 308 LLKKAYEASLSEIKKGHEI----------EKKSLEDLLSE------KQESLEKQINDLKS 351
L K EA L ++++ I EKK LED ++E ++E K + LK+
Sbjct: 964 LEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKN 1023
Query: 352 ENDA----LNEKLKSEEQKRRAREKANLK--------NPQIMYLEQELESLKAVLEIKNE 399
+++A L E+L+ EE++R+ EK K + QI L+ ++ LK L K E
Sbjct: 1024 KHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083
Query: 400 KLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQES 459
+L L ++E+ + K++ + + EL+ ++ A + ++ L E
Sbjct: 1084 EL---QAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEE 1140
Query: 460 LE 461
LE
Sbjct: 1141 LE 1142
Score = 66.2 bits (160), Expect = 7e-11
Identities = 62/289 (21%), Positives = 131/289 (45%), Gaps = 23/289 (7%)
Query: 195 EEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRL 254
++ L + KT+S + R + EK KA + + + EA Q+ + E+ ++ R
Sbjct: 1447 DQLLAEEKTISAKYAEERDRAEAEAR--EKETKALSLARALEEAMEQKAELERLNKQFRT 1504
Query: 255 KEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYE 314
+ + + E EK K L++Q + + E + E++A+ KL L E
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRL-----E 1559
Query: 315 ASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKAN 374
+L +K E + + ++ EK++ L +Q+ ++++E + +E+K+R+ A
Sbjct: 1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE--------DERKQRSMAVAA 1611
Query: 375 LKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEE 434
K LE +L+ L+A ++ N+ +D + ++ KL + +L + EE
Sbjct: 1612 RKK-----LEMDLKDLEAHIDSANKN---RDEAIKQLRKLQAQMKDCMRELDDTRASREE 1663
Query: 435 LKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHN 483
+ A+ ++ + + E LQE L + ++ E +EL ++ N
Sbjct: 1664 ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIAN 1712
Score = 65.5 bits (158), Expect = 1e-10
Identities = 74/309 (23%), Positives = 134/309 (43%), Gaps = 22/309 (7%)
Query: 166 ILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKL 225
I +LK LA + +A ++ +++ ALK+ + L ++ L+ +L + + K
Sbjct: 1071 IAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA 1130
Query: 226 EKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 285
EK + +L EA KTE E+ L T ++LR +E K L+E+
Sbjct: 1131 EKQKRDLGEELEAL-------KTELEDTLDS--TAAQQELRSKREQEVNILKKTLEEE-- 1179
Query: 286 NLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQ 345
HE E+ HS+ +E L + E + +K E K++LE +E+ E +
Sbjct: 1180 --AKTHEAQIQEMRQKHSQAVEELAEQLEQT-KRVKANLEKAKQTLE---NERGELANEV 1233
Query: 346 INDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQD 405
L+ + D+ +++ K E Q + + K N L ++ L+ L+ L Q D
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSD 1293
Query: 406 IKLMKMEK-LVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKES 464
K K+ K + L D + Q+EN + + K +Q+ E+ +E LE+E
Sbjct: 1294 SKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTK----LKQVEDEKNSFREQLEEEE 1349
Query: 465 KVNKRLSME 473
+ L +
Sbjct: 1350 EAKHNLEKQ 1358
Score = 59.3 bits (142), Expect = 8e-09
Identities = 67/316 (21%), Positives = 137/316 (43%), Gaps = 36/316 (11%)
Query: 195 EEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRL 254
EEA++Q L + R E+ ++ + + K+ +EL+ A QQ + KT+ E
Sbjct: 1486 EEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELE 1545
Query: 255 KEFYTREYEKLR----------------DTYIEEAEKYKMQLQEQFDNLNAAHETSKLE- 297
E E KLR E++E+ K QL Q + A E + +
Sbjct: 1546 DELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQR 1605
Query: 298 -IEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDAL 356
+ + +KLE+ K EA + K + K L L ++ ++ + ++++D ++ + +
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM-RELDDTRASREEI 1664
Query: 357 NEKLKSEEQKRRAREKANLKNPQIMYLEQEL---ESLKAVLEIKNEKLHQQ--------D 405
+ K E+K ++ E +++ L++EL E K + + ++L +
Sbjct: 1665 LAQAKENEKKLKSME------AEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 406 IKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESK 465
+ L + +L L ++L+ Q E + R+ K Q++T+ + + +K
Sbjct: 1719 LALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNEN 1778
Query: 466 VNKRLSMENEELLWKL 481
++L +N+EL KL
Sbjct: 1779 ARQQLERQNKELKVKL 1794
Score = 55.8 bits (133), Expect = 9e-08
Identities = 78/363 (21%), Positives = 160/363 (44%), Gaps = 35/363 (9%)
Query: 122 VEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTK--CENQSGFILQLKQLLACGNT- 178
+++ RQK+ +++ + + L K ++ K K EN+ G + ++L G
Sbjct: 1187 IQEMRQKHSQAV----EELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242
Query: 179 ---KFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTV 235
K + + +Q L + E + L+ ++ L+ EL + + + ++L
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 236 YEAFVQQHQ--AEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHET 293
+ A Q Q E + ENR K + + +++ D E ++ QL+E+ + A H
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVED----EKNSFREQLEEEEE---AKHNL 1355
Query: 294 SKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDL--LSEKQE-------SLEK 344
K +I H++ + +KK E S+ ++ E+++K +DL LS++ E LEK
Sbjct: 1356 EK-QIATLHAQVAD-MKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413
Query: 345 QINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNE-KLHQ 403
L+ E D L L + Q EK K Q++ E+ + + A + E + +
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEARE 1473
Query: 404 QDIKLMK----MEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQES 459
++ K + +E+ ++ L K+F+ E E+L + D +L + L++
Sbjct: 1474 KETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533
Query: 460 LEK 462
+E+
Sbjct: 1534 VEE 1536
Score = 54.3 bits (129), Expect = 3e-07
Identities = 65/301 (21%), Positives = 134/301 (44%), Gaps = 39/301 (12%)
Query: 192 SEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQ------HQA 245
+ REE L Q K ++L ++ E++ E+A+ + Q + + A
Sbjct: 1659 ASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGA 1718
Query: 246 EKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEK 305
E + RL+ + E+L + E+ + + + NL + L +E SH++K
Sbjct: 1719 LALEEKRRLEARIAQLEEELEE---EQGNTELINDRLKKANLQIDQINTDLNLERSHAQK 1775
Query: 306 LELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQ 365
E ++ E E+K ++ + +E + K ++ I L+++ L E+L +E +
Sbjct: 1776 NENARQQLERQNKELK----VKLQEMEGTVKSKYKA---SITALEAKIAQLEEQLDNETK 1828
Query: 366 KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKL 425
+R+A K Q+ E++L+ + +L++ +E+ + + K D +L
Sbjct: 1829 ERQAACK------QVRRTEKKLKDV--LLQVDDERRNAEQYK--------DQADKASTRL 1872
Query: 426 KRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGD 485
K+ +++ EE + + A R+L E L+++ E +N+ +S L KL GD
Sbjct: 1873 KQLKRQLEEAEEEAQRANASRRKLQRE---LEDATETADAMNREVS----SLKNKLRRGD 1925
Query: 486 L 486
L
Sbjct: 1926 L 1926
Score = 53.5 bits (127), Expect = 4e-07
Identities = 61/282 (21%), Positives = 121/282 (42%), Gaps = 19/282 (6%)
Query: 188 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 247
+ +L++ +E K+ K++ E++ L+ EL A + ++ R+EL A A
Sbjct: 1662 EEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI-ANSSGKGALA 1720
Query: 248 TERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE 307
E + RL+ + E+L + E+ + + + NL + L +E SH++K E
Sbjct: 1721 LEEKRRLEARIAQLEEELEE---EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNE 1777
Query: 308 LLKKAYEASLSEIK-KGHEIEK------KSLEDLLSEKQESLEKQINDLKSENDALNEKL 360
++ E E+K K E+E K+ L K LE+Q+++ E A +++
Sbjct: 1778 NARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1837
Query: 361 KSEEQKRR--------AREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKME 412
+ E+K + R A Q L+ LK LE E+ + + K++
Sbjct: 1838 RRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQ 1897
Query: 413 KLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQA 454
+ +++ T D + R + R D + R+++ + A
Sbjct: 1898 RELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGA 1939
Score = 30.0 bits (66), Expect = 5.3
Identities = 33/127 (25%), Positives = 60/127 (47%), Gaps = 18/127 (14%)
Query: 358 EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDN 417
E + EE+ + REK ++ E+E+L++ ++ EKL Q+ +L +L
Sbjct: 846 EMMAKEEELVKVREKQLAAENRLT----EMETLQS--QLMAEKLQLQE-QLQAETELCAE 898
Query: 418 NTALVDKLKRFQQENEE----LKARMDKHMAISRQLSTEQAVLQ-------ESLEKESKV 466
L +L +QE EE L+AR+++ + L E+ +Q E LE+E
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958
Query: 467 NKRLSME 473
++L +E
Sbjct: 959 RQKLQLE 965
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 73.2 bits (178), Expect = 5e-13
Identities = 75/322 (23%), Positives = 136/322 (42%), Gaps = 31/322 (9%)
Query: 147 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 206
+KT ++ + Q+G I LK +L K L I++L + + KQ +L +
Sbjct: 540 KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 599
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 266
+ +L+ + T LE+A E + E +Q ++ E++
Sbjct: 600 RVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQ--------------- 644
Query: 267 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI 326
EE + YK L++ + S L+ + S E L K + +SL+ +
Sbjct: 645 ----EEIDNYKKDLKD------LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 694
Query: 327 EKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRR----AREKANLKNPQIMY 382
K+LE L +K+E K + LK ++A E S E R RE K+
Sbjct: 695 RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 754
Query: 383 LEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARM-DK 441
+ L+ + E++NEK + +D K+ ++E+ V + V LK +Q ++ A+M ++
Sbjct: 755 QAEVDRLLEILKEVENEK-NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEE 813
Query: 442 HMAISRQLSTEQAVLQESLEKE 463
L+ LQ+SL K+
Sbjct: 814 ARRREDNLNDSSQQLQDSLRKK 835
Score = 49.3 bits (116), Expect = 8e-06
Identities = 97/436 (22%), Positives = 182/436 (41%), Gaps = 81/436 (18%)
Query: 114 NLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLL 173
N TAL +E++ + R++ + + D EK E+ YK ++ + L+ L
Sbjct: 610 NTDTALTTLEEALAEKERTI-ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDL 668
Query: 174 ACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQ 233
+ K +L + +H S LK+ L L L C K+E ++L+
Sbjct: 669 S---EKEASLLDLKEHASSLASSGLKKDSRLK----TLEIALEQKKEECLKME---SQLK 718
Query: 234 TVYEAFVQQHQA-EKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHE 292
+EA ++ + E ++R L+ TR Y +E+ K + ++ + L E
Sbjct: 719 KAHEAALEARASPEMSDRIQHLEREITR--------YKDESSKAQAEVDRLLEILKEV-E 769
Query: 293 TSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK-------------- 338
K + + +E LE K ++ +K ++EKK +L E
Sbjct: 770 NEKNDKDKKIAE-LERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQL 828
Query: 339 QESLEKQINDLKSENDALNEKLK--SEEQKRRAREKANLKNPQ------IMYLE---QEL 387
Q+SL K+ + ++ +AL E ++ +E + A+E++ N + +M +E QEL
Sbjct: 829 QDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQEL 888
Query: 388 ESLKAVLEIKNEKL----------------HQQDIKLMKMEKLV------DNNTALVDKL 425
ES+KA L + L H +++ MK E L+ D N AL++
Sbjct: 889 ESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELS 948
Query: 426 KRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMEN-EELLWKLHNG 484
++ EE+ A L E+ L + L+++++ +L +N E+ +K +
Sbjct: 949 SSKKKTQEEVAA-----------LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHS 997
Query: 485 DLCSPKRSPTSSAIPL 500
+ + K SP PL
Sbjct: 998 NQTNHKPSPDQIIQPL 1013
Score = 40.0 bits (92), Expect = 0.005
Identities = 64/292 (21%), Positives = 127/292 (43%), Gaps = 26/292 (8%)
Query: 218 ASTTCEKLEKARN----ELQTVYEAFVQQHQAEKTERE----------NRLKEFYTREYE 263
AST L +AR+ +LQT + ++++ + + E N +K F++ E +
Sbjct: 136 ASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELK 195
Query: 264 KLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLEL---LKKAYEASLSEI 320
K R +EA K + +EQ+ + ++ ++ I+A E L + L + ++ S
Sbjct: 196 KERALRKDEASKITIW-KEQYRVVQEENQHMQMTIQALQDE-LRIQRDLNQLFQQDSSS- 252
Query: 321 KKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNE-KLKSEEQKRRAREKANLKNPQ 379
+ G + E+ E+Q +L L E +L+ E QK + N ++
Sbjct: 253 RTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK----QTLNARDES 308
Query: 380 IMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARM 439
I L + L+S K + E+ H++ +L + E V + +L+++ ++ E R
Sbjct: 309 IKKLLEMLQS-KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR 367
Query: 440 DKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKR 491
++ S + Q V++ K S + + L EE+ NG L + +R
Sbjct: 368 FENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEER 419
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 73.2 bits (178), Expect = 5e-13
Identities = 75/322 (23%), Positives = 136/322 (42%), Gaps = 31/322 (9%)
Query: 147 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 206
+KT ++ + Q+G I LK +L K L I++L + + KQ +L +
Sbjct: 512 KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 571
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 266
+ +L+ + T LE+A E + E +Q ++ E++
Sbjct: 572 RVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQ--------------- 616
Query: 267 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI 326
EE + YK L++ + S L+ + S E L K + +SL+ +
Sbjct: 617 ----EEIDNYKKDLKD------LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 666
Query: 327 EKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRR----AREKANLKNPQIMY 382
K+LE L +K+E K + LK ++A E S E R RE K+
Sbjct: 667 RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 726
Query: 383 LEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARM-DK 441
+ L+ + E++NEK + +D K+ ++E+ V + V LK +Q ++ A+M ++
Sbjct: 727 QAEVDRLLEILKEVENEK-NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEE 785
Query: 442 HMAISRQLSTEQAVLQESLEKE 463
L+ LQ+SL K+
Sbjct: 786 ARRREDNLNDSSQQLQDSLRKK 807
Score = 49.3 bits (116), Expect = 8e-06
Identities = 97/436 (22%), Positives = 182/436 (41%), Gaps = 81/436 (18%)
Query: 114 NLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLL 173
N TAL +E++ + R++ + + D EK E+ YK ++ + L+ L
Sbjct: 582 NTDTALTTLEEALAEKERTI-ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDL 640
Query: 174 ACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQ 233
+ K +L + +H S LK+ L L L C K+E ++L+
Sbjct: 641 S---EKEASLLDLKEHASSLASSGLKKDSRLK----TLEIALEQKKEECLKME---SQLK 690
Query: 234 TVYEAFVQQHQA-EKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHE 292
+EA ++ + E ++R L+ TR Y +E+ K + ++ + L E
Sbjct: 691 KAHEAALEARASPEMSDRIQHLEREITR--------YKDESSKAQAEVDRLLEILKEV-E 741
Query: 293 TSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK-------------- 338
K + + +E LE K ++ +K ++EKK +L E
Sbjct: 742 NEKNDKDKKIAE-LERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQL 800
Query: 339 QESLEKQINDLKSENDALNEKLK--SEEQKRRAREKANLKNPQ------IMYLE---QEL 387
Q+SL K+ + ++ +AL E ++ +E + A+E++ N + +M +E QEL
Sbjct: 801 QDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQEL 860
Query: 388 ESLKAVLEIKNEKL----------------HQQDIKLMKMEKLV------DNNTALVDKL 425
ES+KA L + L H +++ MK E L+ D N AL++
Sbjct: 861 ESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELS 920
Query: 426 KRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMEN-EELLWKLHNG 484
++ EE+ A L E+ L + L+++++ +L +N E+ +K +
Sbjct: 921 SSKKKTQEEVAA-----------LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHS 969
Query: 485 DLCSPKRSPTSSAIPL 500
+ + K SP PL
Sbjct: 970 NQTNHKPSPDQIIQPL 985
Score = 40.0 bits (92), Expect = 0.005
Identities = 64/292 (21%), Positives = 127/292 (43%), Gaps = 26/292 (8%)
Query: 218 ASTTCEKLEKARN----ELQTVYEAFVQQHQAEKTERE----------NRLKEFYTREYE 263
AST L +AR+ +LQT + ++++ + + E N +K F++ E +
Sbjct: 136 ASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELK 195
Query: 264 KLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLEL---LKKAYEASLSEI 320
K R +EA K + +EQ+ + ++ ++ I+A E L + L + ++ S
Sbjct: 196 KERALRKDEASKITIW-KEQYRVVQEENQHMQMTIQALQDE-LRIQRDLNQLFQQDSSS- 252
Query: 321 KKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNE-KLKSEEQKRRAREKANLKNPQ 379
+ G + E+ E+Q +L L E +L+ E QK + N ++
Sbjct: 253 RTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK----QTLNARDES 308
Query: 380 IMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARM 439
I L + L+S K + E+ H++ +L + E V + +L+++ ++ E R
Sbjct: 309 IKKLLEMLQS-KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR 367
Query: 440 DKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKR 491
++ S + Q V++ K S + + L EE+ NG L + +R
Sbjct: 368 FENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEER 419
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 73.2 bits (178), Expect = 5e-13
Identities = 100/423 (23%), Positives = 176/423 (41%), Gaps = 74/423 (17%)
Query: 147 EKTLELTQYKTKCENQSGFILQLKQ------LLACGNTKFEALTVV----IQHLLSEREE 196
+K E+++ K + ++Q + +L Q L N + LTV IQ L S+
Sbjct: 2519 KKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNAS 2578
Query: 197 ALKQHKTLSQELVNLRGEL-VTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLK 255
+ L NL EL +T +EK T E +Q+ E ++ L+
Sbjct: 2579 LQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK--MTAKETELQREMHEMAQKTAELQ 2636
Query: 256 EFYTREYEKLR---DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLEL---- 308
E + E +L +EE + K QL+E L + K ++ H +++E
Sbjct: 2637 EELSGEKNRLAGELQLLLEEIKSSKDQLKE----LTLENSELKKSLDCMHKDQVEKEGKV 2692
Query: 309 -------------LKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQ---INDLKSE 352
+K ++A L + K +E+E ++ + L+ K+E L Q I+ LKS
Sbjct: 2693 REEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSS 2752
Query: 353 NDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKME 412
+ LN LK+ Q +K + N LK V ++K E Q KM+
Sbjct: 2753 KEELNNSLKATTQILEELKKTKMDN------------LKYVNQLKKENERAQG----KMK 2796
Query: 413 KLVDNNTALVDKLKRFQQENEELKARMDKHMAIS------RQLSTEQAVLQESLEKESK- 465
L+ + L ++ + Q+E +L+A +K + +L+TE L+E+LE+++K
Sbjct: 2797 LLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKE 2856
Query: 466 ----VNKRLS-------MENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSI 514
++K S +E + + + LCS + S PL P G P PS+
Sbjct: 2857 ADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRGSPLLGPVVPGPSPIPSV 2916
Query: 515 SPR 517
+ +
Sbjct: 2917 TEK 2919
Score = 60.5 bits (145), Expect = 4e-09
Identities = 79/325 (24%), Positives = 147/325 (45%), Gaps = 50/325 (15%)
Query: 147 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 206
EKT EL ++++C + + + + T ++Q L S+ E LK L +
Sbjct: 1986 EKTQELESHQSECLH----------CIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQE 2035
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 266
+L +L + S T +LE +L E V++ ++ + RL E +YEKL
Sbjct: 2036 KLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQA----RLSE---SDYEKLN 2088
Query: 267 DTYIEEA---EKYKMQL-----QEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLS 318
+ EA EK + L QE+ L E ++ IEA ++L + +K
Sbjct: 2089 VSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKL------ 2142
Query: 319 EIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSEN------DALNEKLKSEEQKRRAREK 372
K E E SL+D K E+LE+++ + EN DA N K + E K + E
Sbjct: 2143 ---KERERENDSLKD----KVENLEREL-QMSEENQELVILDAENSKAEVETLKTQIEEM 2194
Query: 373 ANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQ-QE 431
A + E +L +L++ E +++ ++ +L +++KL+ + +L+++ ++ + Q
Sbjct: 2195 AR----SLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQI 2250
Query: 432 NEELKARMDKHMAISRQLSTEQAVL 456
EE K ++ ++L+ A L
Sbjct: 2251 KEESKTAVEMLQNQLKELNEAVAAL 2275
Score = 58.5 bits (140), Expect = 1e-08
Identities = 78/355 (21%), Positives = 153/355 (43%), Gaps = 45/355 (12%)
Query: 158 KCENQS-GFILQLKQLLACGNTKFEALTVVIQHLLSEREEAL------------KQHKTL 204
+C NQS F ++K NT E + +Q ++++E +L ++ +
Sbjct: 514 QCLNQSQNFAEEMK----AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDC 569
Query: 205 SQELVNLRGELVTASTTCEKLEKARNELQTVYEAF-VQQHQAEKTERENRLKEFYTREYE 263
SQ+L+ R + +KL K E + + A +++ + E+ + E L + E E
Sbjct: 570 SQDLLKKREHHIEQLN--DKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENE 627
Query: 264 KLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKG 323
KL + + E K LQ + ++L +T +++ ++E++ L+ E EI+
Sbjct: 628 KL----LTQMESEKENLQSKINHLETCLKTQQIKSH-EYNERVRTLEMDRENLSVEIRNL 682
Query: 324 HEIEKKSLEDLLSEKQESLEKQ----INDLKSENDALNEKLKSEE---QKRRAREKANLK 376
H + ++ ++K +E Q +D K + + N LK+ + Q K L
Sbjct: 683 HNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLL 742
Query: 377 NPQIMY-------LEQELESLKAVLEIKNEKL-----HQQDIKLMKMEKLVDNNTA-LVD 423
+ +IM L E ESL+ +L+ K+ L HQ+ + + + ++ A ++
Sbjct: 743 SNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIG 802
Query: 424 KLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELL 478
+ E E + D+ S L L+ SLE + ++N L + EEL+
Sbjct: 803 EQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELV 857
Score = 57.0 bits (136), Expect = 4e-08
Identities = 73/352 (20%), Positives = 154/352 (43%), Gaps = 61/352 (17%)
Query: 149 TLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH------- 201
T + Q TK + +L + L+C E+ ++ + E+E+ ++
Sbjct: 347 TAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRS 406
Query: 202 -KTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEF--- 257
+TL QE + ++ L ++L++A+N + V +A + + + K + EN L+EF
Sbjct: 407 FQTLDQECIQMKARLT------QELQQAKN-MHNVLQAELDKLTSVKQQLENNLEEFKQK 459
Query: 258 YTREYEKLRDTYIEEAE-KYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEAS 316
R + + + I+E E + M+ ++ +NL +H K E H E
Sbjct: 460 LCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAR-EVCHLEA----------- 507
Query: 317 LSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLK 376
E K+++ L++ Q E ++K++N + L+ ++K +E +
Sbjct: 508 ----------ELKNIKQCLNQSQNFAE----EMKAKNTSQETMLRDLQEKINQQENS--- 550
Query: 377 NPQIMYLEQELESLK-AVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEEL 435
LE LK AV +++ ++ QD+ L K E ++ L DKL + ++E++ L
Sbjct: 551 --------LTLEKLKLAVADLEKQRDCSQDL-LKKREHHIEQ---LNDKLSKTEKESKAL 598
Query: 436 KARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLC 487
+ ++ +L E+ + + K+ ++ E E L K+++ + C
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETC 650
Score = 52.0 bits (123), Expect = 1e-06
Identities = 69/283 (24%), Positives = 125/283 (44%), Gaps = 34/283 (12%)
Query: 241 QQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEA 300
Q+H A + E E + E + + + E + ++ + +NL T++L+ E
Sbjct: 2352 QEHAALEAENSKGEVETLKAKIEGMTQS-LRGLELDVVTIRSEKENL-----TNELQKEQ 2405
Query: 301 SHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALN--- 357
+LE++ ++E L E E EK +++ S E L+ Q+ +L AL+
Sbjct: 2406 ERISELEIINSSFENILQE----KEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQ 2461
Query: 358 EKLKSEEQKRRAR------EKANL-------KNPQIMY------LEQELESLKAVLEIKN 398
E K++EQ ++ EKA L KN I+ L QE+E K LE K+
Sbjct: 2462 EACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKD 2521
Query: 399 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQE 458
E++ + ++ E+LV + + + + ++++N EL+ + + L ++ A LQ+
Sbjct: 2522 EEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQD 2581
Query: 459 SLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQ 501
+LE K L ENE L K+ T+ LQ
Sbjct: 2582 TLEVLQSSYKNL--ENELELTKMDKMSFVEKVNKMTAKETELQ 2622
Score = 50.8 bits (120), Expect = 3e-06
Identities = 83/375 (22%), Positives = 160/375 (42%), Gaps = 59/375 (15%)
Query: 147 EKTLELTQYKTKCEN-------QSGFILQ--LKQLLACGNT----KFEALTVV------I 187
EK L+L K + E +S +L+ LK+L T K E +++ I
Sbjct: 910 EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREI 969
Query: 188 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVY--EAFVQQHQA 245
+ L E + + +L+QE +NL + + + ++ EK+ +EL Y E + +
Sbjct: 970 EELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRC 1029
Query: 246 EKTERENR-LKEFYTREYEK------LRDTYIEEAEKYKMQLQEQFDNLNAAHET--SKL 296
E+T L + Y EK L + E K +L++ + H+ +KL
Sbjct: 1030 EETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKL 1089
Query: 297 EIEASHSE----KLELLKKAYEASLSEIKKGHEIEKKSLED---LLSEKQESLEKQINDL 349
++ +LE +++A + +++ + + E L+ L E+Q ++K++NDL
Sbjct: 1090 AFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDL 1149
Query: 350 KSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLK--------AVLEIKNEKL 401
EN+ L + +K++ E NL++ I +E ES + LE+K L
Sbjct: 1150 LQENEQLMKVMKTK------HECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISL 1203
Query: 402 HQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLE 461
+ +L+++E ++ N K + Q+ +E + + I L T LQ+
Sbjct: 1204 DSYNAQLVQLEAMLRN------KELKLQESEKEKECLQHELQTIRGDLETSN--LQDMQS 1255
Query: 462 KESKVNKRLSMENEE 476
+E K ++ EE
Sbjct: 1256 QEISGLKDCEIDAEE 1270
Score = 50.4 bits (119), Expect = 4e-06
Identities = 76/348 (21%), Positives = 149/348 (42%), Gaps = 41/348 (11%)
Query: 152 LTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHK-TLSQELVN 210
LTQ +++ EN I L+ L K H +ER L+ + LS E+ N
Sbjct: 630 LTQMESEKENLQSKINHLETCLKTQQIK--------SHEYNERVRTLEMDRENLSVEIRN 681
Query: 211 LRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAE------KTERENRLKEFYTREYEK 264
L L + S E + A ELQ E Q+HQ E KT + E + +
Sbjct: 682 LHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQL 741
Query: 265 LRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGH 324
L + +++ Y+ L ++++L ++ + + + LL + ++
Sbjct: 742 LSNEIMDKDRCYQ-DLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANI 800
Query: 325 EIEKKSLEDLLSE---KQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIM 381
E+ S+ SE + + K L++ D+L L+S++Q N +
Sbjct: 801 IGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQ----------MNSDLQ 850
Query: 382 YLEQELESLKAVLE---IKNEKLHQQDI--KLMKMEKLVDNNTA----LVDKLKRFQQEN 432
+EL +K +E +K E++HQ + ++ KL ++ +A + + L + +
Sbjct: 851 KQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE 910
Query: 433 EELKARMDK---HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 477
+EL+ DK A ++L +L++SL++ +++ LS+E +E+
Sbjct: 911 KELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEM 958
Score = 46.6 bits (109), Expect = 5e-05
Identities = 51/205 (24%), Positives = 91/205 (44%), Gaps = 22/205 (10%)
Query: 284 FDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLE 343
FDN ++ H +L+ ++ EL K E L +GHE E K + E Q LE
Sbjct: 271 FDNSSSPHLLDQLK-----AQNQELRNKINELELR--LQGHEKEMKGQVNKFQELQLQLE 323
Query: 344 KQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQ 403
K +L + LN K ++ R + + + + LEQ+L+ L ++ ++ +
Sbjct: 324 KAKVELIEKEKVLN---KCRDELVRTTAQYDQASTKYTALEQKLKKLTE--DLSCQRQNA 378
Query: 404 QDIKLMKMEKLVDNNTALVDKLKRFQ-------QENEELKARMDKHMAISRQLSTEQAVL 456
+ + +K+ + ++L R Q QE ++KAR+ + + +Q VL
Sbjct: 379 ESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQEL---QQAKNMHNVL 435
Query: 457 QESLEKESKVNKRLSMENEELLWKL 481
Q L+K + V ++L EE KL
Sbjct: 436 QAELDKLTSVKQQLENNLEEFKQKL 460
Score = 41.6 bits (96), Expect = 0.002
Identities = 46/212 (21%), Positives = 86/212 (40%), Gaps = 26/212 (12%)
Query: 304 EKLELLKKAYEASLSEIKKGHEI-------EKKSLEDLLSEKQESLEKQINDLKSENDAL 356
E+LE L + Y SL ++++ E E + LE LLS +++ L+ SEN+
Sbjct: 1550 EELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQW 1609
Query: 357 NEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVD 416
+KL S + ++ A K + + LE E+ A L+++ L + + + E +
Sbjct: 1610 QQKLTSVTLEMESKLAAEKKQTEQLSLELEV----ARLQLQGLDLSSRSLLGIDTEDAIQ 1665
Query: 417 NNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEE 476
D K E E + D H + +K+++ + L +E
Sbjct: 1666 GRNESCDISKEHTSETTERTPKHDVH---------------QICDKDAQQDLNLDIEKIT 1710
Query: 477 LLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGS 508
+ CS ++SP ++ P + GS
Sbjct: 1711 ETGAVKPTGECSGEQSPDTNYEPPGEDKTQGS 1742
Score = 36.2 bits (82), Expect = 0.074
Identities = 55/208 (26%), Positives = 94/208 (45%), Gaps = 50/208 (24%)
Query: 281 QEQFDNLNAAHETSKLEIEASHSEKLELLK------KAYEASLSEIKKGHEIEKK-SLED 333
QE NL +L ++ + +E L LL + E+ L+E+K E++ K L++
Sbjct: 1766 QEDIHNL-------QLRVKETSNENLRLLHVIEDRDRKVESLLNEMK---ELDSKLHLQE 1815
Query: 334 L-LSEKQES---LEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELES 389
+ L K E+ LEK + +LK EN L+EKL E + + +++ + E
Sbjct: 1816 VQLMTKIEACIELEKIVGELKKENSDLSEKL----------EYFSCDHQELLQRVETSEG 1865
Query: 390 LKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKR--FQQENEELKARMDK----HM 443
L + LE+ +K ++DI DN + D K ENE + R +K H
Sbjct: 1866 LNSDLEMHADKSSREDIG--------DNVAKVNDSWKERFLDVENELSRIRSEKASIEHE 1917
Query: 444 AISRQ-----LSTEQAVLQESLEKESKV 466
A+ + + TE+ L++ E + KV
Sbjct: 1918 ALYLEADLEVVQTEKLCLEKDNENKQKV 1945
Score = 32.3 bits (72), Expect = 1.1
Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 9/89 (10%)
Query: 379 QIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKAR 438
+I LE +L+ LK + + +L + L K ++ V+N LKR Q E+
Sbjct: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICES 78
Query: 439 MDKHMAISRQLSTEQAVLQESLEKESKVN 467
++K T+Q + E KES+VN
Sbjct: 79 LEK---------TKQKISHELQVKESQVN 98
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 72.8 bits (177), Expect = 7e-13
Identities = 103/419 (24%), Positives = 201/419 (47%), Gaps = 62/419 (14%)
Query: 117 TALNAVEKSRQKNPRSLCIQPQTAPDALPP-EKTLELTQYKTKCENQSGFILQLKQLLAC 175
T + ++K + + +L + T D L +L+ ++ + + ENQ G L C
Sbjct: 836 TTVTELQKVKMEK-EALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTC 894
Query: 176 GNTKFEALTVVIQHLLSEREE---ALKQHKTLSQ----ELVNLRGELVTASTTCEKLEKA 228
K + L V +++ L E++E +L++ K S EL +++ +L+ A T ++ EK
Sbjct: 895 KELKHQ-LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953
Query: 229 R-------NELQTVYEAFVQQHQA----------EKTERENRLKEFYTR-------EYEK 264
NEL+ E +Q +A +KTE EN+L++ T+ E EK
Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEK 1013
Query: 265 ---LRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK 321
L++ Y + E +K QLQ F + ++ +++ S EKL L ++ ++ ++I
Sbjct: 1014 ISVLQNNYEKSQETFK-QLQSDFYGRESELLATRQDLK-SVEEKLSLAQEDLISNRNQIG 1071
Query: 322 KGHEI------EKKSLEDLLSEKQESLE---KQINDLKSENDALNEKLKSEEQKRRAREK 372
+++ K +LE ++K++ L+ K + D++ E ++L +E+ K E+
Sbjct: 1072 NQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEE 1131
Query: 373 ANLKNP-QIMYLEQELES--LKAVLEIKNEKLHQQDIKLMKMEKL--VDNNTALVDKLKR 427
+ +I L +EL+S L+++ EI N K +Q + K+E D+ A V++ KR
Sbjct: 1132 IKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKR 1191
Query: 428 FQQ--------ENEELKAR-MDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 477
QQ E EELK ++K + ++ ++ +++ E E+K+ +++ NE L
Sbjct: 1192 NQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENL 1250
Score = 68.9 bits (167), Expect = 1e-11
Identities = 97/437 (22%), Positives = 193/437 (44%), Gaps = 49/437 (11%)
Query: 70 IKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNLFTALNAVEKSRQKN 129
+K E K + + L+ +++ H L++T + L A +++ RQ +
Sbjct: 391 LKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET------ERQLGEAHGRLKEQRQLS 444
Query: 130 PRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQL---KQLLACGNTKFEALTVV 186
L + Q D LE Q K K N + QL KQ ++ T
Sbjct: 445 SEKLMDKEQQVADLQLKLSRLE-EQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAK 503
Query: 187 IQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQA- 245
++ ++ E+ L+Q Q++ NL L + LEK R +L +A +
Sbjct: 504 LREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVL 563
Query: 246 -EKTERENRLKEFYTREYEKLR---DTYIEEAEKYKMQLQEQFDNLNAAH------ETSK 295
+ E+ + L+E T+ EKL+ +++ + E Q+QEQ +L AA ETS
Sbjct: 564 NQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSV 623
Query: 296 LEIEASHSE------KLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESL---EKQI 346
E+ + +E +L++ KA L + ++ L++ L Q +L ++++
Sbjct: 624 NELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQEL 683
Query: 347 NDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDI 406
N + ++ D + KL+ ++Q+ ++ +++LK + YL E ++ + +IK + ++
Sbjct: 684 NKITTQLDQVTAKLQ-DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEV 742
Query: 407 KLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAV-------LQES 459
K K + L D L++ +Q N +L+ R + +S+QL E+ + LQ+
Sbjct: 743 KASKEQALQD--------LQQQRQLNTDLELRATE---LSKQLEMEKEIVSSTRLDLQKK 791
Query: 460 LEKESKVNKRLSMENEE 476
E + ++L+ + EE
Sbjct: 792 SEALESIKQKLTKQEEE 808
Score = 56.2 bits (134), Expect = 7e-08
Identities = 72/346 (20%), Positives = 153/346 (44%), Gaps = 27/346 (7%)
Query: 151 ELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSE--REEALKQHKTLSQEL 208
E+ K+K + + +Q + + VIQ L +E + ++ L +EL
Sbjct: 171 EIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKEL 230
Query: 209 VNLRGEL----VTASTTCEKLEKARNELQTVY---EAFVQQHQAEKTERENRLKEFYTRE 261
V ++ + + EKL+ +LQ+ Y EA + Q ++E + + Y +E
Sbjct: 231 VQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVA-VYVQE 289
Query: 262 YEKLRDTYIEEAEKYK------MQLQEQFDNLNAAHE---TSKLEIEAS-HSEKLELLKK 311
+KL+ + E +K + ++ ++ + L H SK I+A+ H + L+ +
Sbjct: 290 LQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQL 349
Query: 312 AYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRARE 371
S SE H I + E E + L++++++++++ L + K +Q+R +E
Sbjct: 350 QSRLSASETSL-HRIHVELSEK--GEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKE 406
Query: 372 KANLK-NPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQ 430
+ L+ +I L +L + L + +L +Q + + EKL+D + D + +
Sbjct: 407 QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQ--RQLSSEKLMDKEQQVADLQLKLSR 464
Query: 431 ENEELKARMDKHMAISRQL-STEQAVLQESLEKESKVNKRLSMENE 475
E+LK ++ + QL T+Q ++ ++S K +N+
Sbjct: 465 LEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQND 510
Score = 55.8 bits (133), Expect = 9e-08
Identities = 85/396 (21%), Positives = 162/396 (40%), Gaps = 53/396 (13%)
Query: 95 VSRAHVHLMKTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDAL---PPEKTLE 151
V HL + S + LN+ ++ L IQ + + L KT +
Sbjct: 602 VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQ 661
Query: 152 LTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHL---LSEREEALKQHK----TL 204
+ + + +Q L T+ + +T +Q S+ E LK++K +L
Sbjct: 662 RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721
Query: 205 SQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEK 264
Q+ L G++ +KLE E++ E +Q Q ++ + N E E K
Sbjct: 722 EQKTEELEGQI-------KKLEADSLEVKASKEQALQDLQQQR--QLNTDLELRATELSK 772
Query: 265 LRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGH 324
+ E ++ LQ++ + L E+ K ++ EK ++LK+ +E E K H
Sbjct: 773 QLEMEKEIVSSTRLDLQKKSEAL----ESIKQKLTKQEEEK-QILKQDFETLSQETKIQH 827
Query: 325 EIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLE 384
E ++ ++E Q+ +K E +AL +L + + K ++ +LKN + + +
Sbjct: 828 EELNNRIQTTVTELQK--------VKMEKEALMTELSTVKDKL-SKVSDSLKNSKSEFEK 878
Query: 385 QELESLKAVLEIKN---EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 441
+ + A+L+++ E HQ +++ NT +E +ELK ++K
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQLQVQM--------ENTL---------KEQKELKKSLEK 921
Query: 442 HMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 477
S QL E +QE L + K+ E ++L
Sbjct: 922 EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957
Score = 54.3 bits (129), Expect = 3e-07
Identities = 68/267 (25%), Positives = 125/267 (46%), Gaps = 53/267 (19%)
Query: 191 LSEREEALKQHKTLS-QELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTE 249
+++ E LK HK S +E+ NL+ + L + + ELQ ++ + EK
Sbjct: 1140 ITKLNEELKSHKLESIKEITNLKDAK-------QLLIQQKLELQGKADSLKAAVEQEKRN 1192
Query: 250 RENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELL 309
++ LK+ +E E+L+ +IE+ K +++E+ + E + KL +
Sbjct: 1193 QQI-LKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE---------NEAKLTMQ 1242
Query: 310 KKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRA 369
A +L +KK E +S + +SE LEKQ +DL+ E L +++ + +RRA
Sbjct: 1243 ITALNENLGTVKK----EWQSSQRRVSE----LEKQTDDLRGEIAVLEATVQNNQDERRA 1294
Query: 370 REKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQ 429
+ LK E E+E L+ K++++++ +DN TA V +L R
Sbjct: 1295 LLERCLKG------EGEIEKLQT--------------KVLELQRKLDNTTAAVQELGR-- 1332
Query: 430 QENEELKARMDKH-MAISRQLSTEQAV 455
EN+ L+ KH A++R+ + + V
Sbjct: 1333 -ENQSLQI---KHTQALNRKWAEDNEV 1355
Score = 50.8 bits (120), Expect = 3e-06
Identities = 84/332 (25%), Positives = 138/332 (41%), Gaps = 62/332 (18%)
Query: 179 KFEALTVVIQHLLSEREEA--LKQH-KTLSQELV----NLRGELVTASTTCEKLEKARNE 231
K EAL + Q L + EE LKQ +TLSQE L + T T +K++ +
Sbjct: 791 KSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEA 850
Query: 232 LQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIE---EAEKYKMQLQEQFDN-L 287
L T + +N EF +E +K + ++ ++ K QLQ Q +N L
Sbjct: 851 LMTELSTVKDKLSKVSDSLKNSKSEF-EKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
Query: 288 NAAHETSKL---EIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEK 344
E K E EASH KLEL S+++ L + Q +L++
Sbjct: 910 KEQKELKKSLEKEKEASHQLKLEL--------------------NSMQEQLIQAQNTLKQ 949
Query: 345 QINDLKSENDALNEKLKSEEQKRRARE------------KANLKN---PQIMYLEQELES 389
+ + +NE +S EQK++ E K L+N Q+ QEL +
Sbjct: 950 NEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAA 1009
Query: 390 LK---AVLEIKNEKLH------QQDIKLMKMEKLVDNN--TALVDKLKRFQQENEELKAR 438
K +VL+ EK Q D + E L ++ +KL Q++ + +
Sbjct: 1010 EKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQ 1069
Query: 439 MDKHMAISRQLSTEQAVL-QESLEKESKVNKR 469
+ + ++L T +A L Q+S +KE ++ +R
Sbjct: 1070 IGNQNKLIQELKTAKATLEQDSAKKEQQLQER 1101
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 72.4 bits (176), Expect = 9e-13
Identities = 77/326 (23%), Positives = 146/326 (44%), Gaps = 29/326 (8%)
Query: 167 LQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLE 226
LQL+++ A K + + I L + + +K+ K + + +L + L
Sbjct: 969 LQLEKVTA--EAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 227 KARNELQTVYEAFVQQ-HQAEKTERE-NRLKEFYTREYEKLRDTYIE---EAEKYKMQLQ 281
K RN+ + + ++ + EKT +E + K E L+D E + ++ K+QL
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086
Query: 282 EQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQES 341
++ + L A ++ + E H + + +A ++E+++ E EK S +
Sbjct: 1087 KKEEELQGA--LARGDDETLHKNNALKVVRELQAQIAELQEDFESEKAS--------RNK 1136
Query: 342 LEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE--IKNE 399
EKQ DL E +AL +L+ A+++ K EQE+ LK LE KN
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR------EQEVAELKKALEEETKNH 1190
Query: 400 KLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQES 459
+ QD++ L + + L ++ KRF+ E+ K ++ +++L+ E VLQ+
Sbjct: 1191 EAQIQDMRQRHATALEELSEQL-EQAKRFKANLEKNKQGLETD---NKELACEVKVLQQV 1246
Query: 460 LEKESKVNKRLSMENEELLWKLHNGD 485
+ K+L + +EL K+ GD
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGD 1272
Score = 70.1 bits (170), Expect = 5e-12
Identities = 93/406 (22%), Positives = 169/406 (41%), Gaps = 57/406 (14%)
Query: 123 EKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEA 182
E++RQK S I+ E+ E + + E Q +L L+ LA K +
Sbjct: 1326 EETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQ---VLALQSQLADTKKKVDD 1382
Query: 183 LTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFV-- 240
I+ L +++ LK + LSQ L + +KLEK +N LQ +
Sbjct: 1383 DLGTIESLEEAKKKLLKDAEALSQRLEE-------KALAYDKLEKTKNRLQQELDDLTVD 1435
Query: 241 ---QQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLE 297
Q+ A E++ + + E + + Y EE ++ + + +E+ A LE
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREK--ETKALSLARALE 1493
Query: 298 IEASHSEKLELLKKAYEASLSEI--------KKGHEIEK--KSLEDLLSEKQESLEKQIN 347
E+ E K A + ++ K HE+EK ++LE + E + LE+ +
Sbjct: 1494 EALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELED 1553
Query: 348 DLKSENDA----------LNEKLKSEEQKR--RAREKANLKNPQIMYLEQELESLKA--V 393
+L++ DA + + + + Q R + EK L Q+ LE ELE +
Sbjct: 1554 ELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA 1613
Query: 394 LEIKNEKLHQQDIKLMKME---------KLVDNNTALVDKLKRFQQENEELKARMDKHMA 444
L + ++K + D+K ++ + +++ L ++K +Q+E EE +A D+ A
Sbjct: 1614 LAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFA 1673
Query: 445 ISRQ-------LSTEQAVLQESLEKESKVNKRLSMENEELLWKLHN 483
S++ L E LQE L + + E +EL ++ N
Sbjct: 1674 QSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN 1719
Score = 68.2 bits (165), Expect = 2e-11
Identities = 87/313 (27%), Positives = 140/313 (44%), Gaps = 47/313 (15%)
Query: 188 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARN----ELQTVYEAFVQQH 243
+ L ++ EE LK + ++ + GEL ++L + +N +LQ E F +
Sbjct: 852 EELQAKDEELLK----VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907
Query: 244 Q------AEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQ-----LQEQFDNLNAAHE 292
+ A+K E E L + +R E+ I + EK KMQ L+EQ D A +
Sbjct: 908 EMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQ 967
Query: 293 TSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI-EKKSLEDLLSE------KQESLEKQ 345
KL++E +E ++ K E L E + I EKK +ED ++E ++E K
Sbjct: 968 --KLQLEKVTAEA-KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKN 1024
Query: 346 INDLKSENDA----LNEKLKSEEQKRRAREKANLK--------NPQIMYLEQELESLKAV 393
+ ++++ + L E+LK EE+ R+ EKA K QI L+ +++ LK
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1084
Query: 394 LEIKNEKLHQQDIKLMKMEKLVDNNT-----ALVDKLKRFQQENEELKARMDKHMAISRQ 448
L K E+L Q + E L NN L ++ Q++ E KA +K R
Sbjct: 1085 LAKKEEEL-QGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143
Query: 449 LSTEQAVLQESLE 461
LS E L+ LE
Sbjct: 1144 LSEELEALKTELE 1156
Score = 62.4 bits (150), Expect = 1e-09
Identities = 78/361 (21%), Positives = 153/361 (42%), Gaps = 81/361 (22%)
Query: 178 TKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 237
TK +L ++ L +EE +Q+K L ++ +L +LEK++ L+
Sbjct: 1483 TKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALE---- 1538
Query: 238 AFVQQHQAEKTERENRLKEFYTREYEKLR----------------DTYIEEAEKYKMQLQ 281
QQ + +T+ E E E KLR T E+ E+ K L
Sbjct: 1539 ---QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 282 EQFDNLNAAHETSK---------------------LEIEASHSEKLELLK--KAYEASLS 318
+Q L A E + +IEA++ + E++K + +A +
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 319 EIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLK-- 376
+ ++ E + S +++ ++ +ES EK++ L++E L E+L S E+ RR E+ +
Sbjct: 1656 DYQRELEEARASRDEIFAQSKES-EKKLKSLEAEILQLQEELASSERARRHAEQERDELA 1714
Query: 377 --------------------NPQIMYLEQELESLKAVLEIKNEKLHQQDIKL--MKMEKL 414
+I LE+ELE ++ +E+ N++ + +++ + E
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 415 VDNNTALV--DKLKRFQQENEELKARM--------DKHMAISRQLSTEQAVLQESLEKES 464
+ + A + ++ +++N+ELKA++ K A L + L+E LE+E+
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 465 K 465
K
Sbjct: 1835 K 1835
Score = 59.7 bits (143), Expect = 6e-09
Identities = 88/356 (24%), Positives = 151/356 (42%), Gaps = 87/356 (24%)
Query: 192 SEREEALKQHKTLSQELVNLRGELV-TASTTCE------KLEKARNELQTVYEAFVQQHQ 244
+ R +A KQ + LS+EL L+ EL T TT K E+ EL+ E + H+
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191
Query: 245 AEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQE-----QFDNLNAA--------- 290
A+ + R + E+L + +E+A+++K L++ + DN A
Sbjct: 1192 AQIQDMRQR----HATALEELSEQ-LEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV 1246
Query: 291 -----HETSKL-----EIEASHSE----KLELLKKAYEAS---------LSEI-KKGHEI 326
H+ KL E+ A SE ++EL +KA + L E KKG +
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306
Query: 327 EKK--SLEDLLSEKQESLEKQ----------INDLKSENDALNEKLKSEEQKRRAREK-- 372
K SLE L + QE L+++ I L+ E ++L E+ + EE+ R+ EK
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366
Query: 373 -------ANLKNP------QIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNT 419
A+ K I LE+ + L E +++L ++ + K+EK +
Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN--- 1423
Query: 420 ALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENE 475
R QQE ++L +D ++ L +Q + L +E ++ R + E +
Sbjct: 1424 -------RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERD 1472
Score = 58.5 bits (140), Expect = 1e-08
Identities = 72/309 (23%), Positives = 129/309 (41%), Gaps = 26/309 (8%)
Query: 190 LLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQA---E 246
+ ++ +E+ K+ K+L E++ L+ EL ++ E+ R+EL A E
Sbjct: 1671 IFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDE 1730
Query: 247 KTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKL 306
K E R+ + E+ + + K LQ N A E S + + ++L
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQL 1790
Query: 307 ELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQK 366
E K +A L E++ + + K+ L K LE+Q+ E A N+ ++ E+K
Sbjct: 1791 ERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKK 1850
Query: 367 RR--------AREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNN 418
+ R A+ Q+ ++ LK LE E+ + + K+++ +D+
Sbjct: 1851 LKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDA 1910
Query: 419 TALVDKLKRFQQENEELKARMDKHMAIS--------RQLSTEQAVLQ----ESLEKESKV 466
T + L R E LK R+ + IS RQL E A L+ ++ K S V
Sbjct: 1911 TEANEGLSR---EVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDV 1967
Query: 467 NKRLSMENE 475
N+ ++E
Sbjct: 1968 NETQPPQSE 1976
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 72.0 bits (175), Expect = 1e-12
Identities = 78/324 (24%), Positives = 149/324 (45%), Gaps = 68/324 (20%)
Query: 181 EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFV 240
E + ++ L S+ E ++++ TL Q L GEL R L+ +++ +
Sbjct: 645 ERMRANLEELRSQHNEKVEENSTLQQRLEESEGEL-------------RKNLEELFQVKM 691
Query: 241 Q--QHQAEKTERENRLKEFYT------REYEKLRDTYIEEAEKYKMQLQ-------EQFD 285
+ QHQ E + +++L E + R ++ + IEE + K LQ EQ D
Sbjct: 692 EREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQED 751
Query: 286 -------NLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLS-- 336
L A K E+ +SH ++++ LK+ Y+A L +++ E K++E L S
Sbjct: 752 LLRKRERELTALKGALKEEV-SSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRS 810
Query: 337 ----EKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKA 392
+ Q E ++ L+ EN+ L +SEE +RR + L++++E LK
Sbjct: 811 NTSEQDQAGTEMRVKLLQEENEKLQG--RSEELERR-----------VAQLQRQIEDLKG 857
Query: 393 VLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 452
E L + + ++ ++E+ ALV K +E E + AR A+ +L
Sbjct: 858 DEAKAKETLKKYEGEIRQLEE------ALVHARK---EEKEAVSAR----RALENELEAA 904
Query: 453 QAVLQESLEKESKVNKRLSMENEE 476
Q L ++ +++ +++++L E+E+
Sbjct: 905 QGNLSQTTQEQKQLSEKLKEESEQ 928
Score = 60.5 bits (145), Expect = 4e-09
Identities = 65/295 (22%), Positives = 128/295 (43%), Gaps = 37/295 (12%)
Query: 192 SEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERE 251
SE ++ L+Q L+ E+ L+ +L + +++ R ++ E QH EK E
Sbjct: 607 SEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHN-EKVEEN 665
Query: 252 NRLKEFYTREYEKLRDTYIE------EAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEK 305
+ L++ +LR E E E+++ ++++ D L+ H+ + EK
Sbjct: 666 STLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREK 725
Query: 306 LELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQES---LEKQINDLKSENDALNEKLKS 362
L+++ +A K+ L+DLL K+E L K+ +L + AL E++ S
Sbjct: 726 GALIEELLQA------------KQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSS 773
Query: 363 EEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALV 422
+Q E LK EQ L+A+ E E ++ + +
Sbjct: 774 HDQ-----EMDKLK-------EQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTE 821
Query: 423 DKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 477
++K Q+ENE+L+ R ++ + R+++ Q +++ E+K + L E+
Sbjct: 822 MRVKLLQEENEKLQGRSEE---LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEI 873
Score = 50.4 bits (119), Expect = 4e-06
Identities = 95/428 (22%), Positives = 171/428 (39%), Gaps = 108/428 (25%)
Query: 152 LTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNL 211
+ Q + + E+ G + K+ L + L + H E +EA+ + L EL
Sbjct: 845 VAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAA 904
Query: 212 RGELVTA--------------STTCEKLEKARN--------------------------- 230
+G L S E+L + +N
Sbjct: 905 QGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEAS 964
Query: 231 -----ELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 285
ELQ + + ++++ E E + +LKE T E EK R T ++ ++ ++ +E D
Sbjct: 965 RTSTLELQNQLDEYKEKNRRELAEMQRQLKE-KTLEAEKSRLTAMKMQDEMRLMEEELRD 1023
Query: 286 NLNAAHET---------------SKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKS 330
A E +LE ++ + L K E +S+++ E E+++
Sbjct: 1024 YQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELE-EERN 1082
Query: 331 LEDLLSEK----QESLEKQINDLKSENDA-------------LNEKLKS-----EEQKRR 368
DLLSE+ +E +E+ N+L E A N+ LKS E R
Sbjct: 1083 NSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSYRS 1142
Query: 369 AREKANLK-NPQIMYLEQELESL---KAVLEIKNEKLHQQDIKLMKME------KLVDNN 418
++E ++ +I LE LES +A L++ N +L ++ +K + M+ L D
Sbjct: 1143 SKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRL-ERKVKELVMQVDDEHLSLTDQK 1201
Query: 419 TALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRL-----SME 473
L +LK +++ EE + +D+ L + + LQ LE++ +N+ L SM+
Sbjct: 1202 DQLSLRLKAMKRQVEEAEEEIDR-------LESSKKKLQRELEEQMDMNEHLQGQLNSMK 1254
Query: 474 NEELLWKL 481
+ L KL
Sbjct: 1255 KDLRLKKL 1262
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 71.6 bits (174), Expect = 2e-12
Identities = 85/343 (24%), Positives = 146/343 (42%), Gaps = 79/343 (23%)
Query: 188 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 247
+ L +E K+++ L +++ NL+ TCEK+E E +
Sbjct: 628 EELENELHHLEKENELLQKKITNLK-------ITCEKIEALEQE-------------NSE 667
Query: 248 TERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE 307
ERENR + ++ L +E EK QL E+ NL L+ + +L+
Sbjct: 668 LERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEE--NLELRRNVESLKCASMKMAQLQ 724
Query: 308 LLKKAYEASLSEIKKGHE--------------------IEKKSLEDLL---SEKQESLEK 344
L K E+ ++KKG E IE + L+ L ++K + LE
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 345 QINDLKSENDALN---EKLKSEEQKRRAREKANLKNPQ--------IMYLEQELESLKAV 393
++ DL+ EN L E+LK ++ EK N Q LE+E + L+
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 394 LEIKNEKLHQQDIKLMKMEKLVDNNTALVD---------KLKRFQQENEEL--KARMD-- 440
EIK+ L + ++K+ +EK +N T + +LK ++EN+EL +A +D
Sbjct: 845 AEIKDTTLEENNVKIGNLEK--ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
Query: 441 -----KHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELL 478
+ +S +L T+Q + LEK + +++ + E LL
Sbjct: 903 TLVTLREDLVSEKLKTQQ--MNNDLEKLTHELEKIGLNKERLL 943
Score = 69.3 bits (168), Expect = 8e-12
Identities = 81/325 (24%), Positives = 146/325 (44%), Gaps = 43/325 (13%)
Query: 188 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQA-- 245
QHL E +A + + L QEL +L+ E++E LQ + ++
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Query: 246 ----------EKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHET-- 293
EK R ++L+ +R E+L D E YK +++E ++ ET
Sbjct: 307 MYRDELDALREKAVRVDKLESEVSRYKERLHD-----IEFYKARVEELKEDNQVLLETKT 361
Query: 294 ---SKLEIEASHSEKLELLKK---AYEASLSEIKKGHEIEKKSLEDLLSEKQ--ESLEKQ 345
+LE + S+KL L+K +A L +++ ++++K +E+L+ E E +KQ
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 346 IND------LKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESL-KAVLEIKN 398
D + E + +L QK E L + +++ LE E +SL K V E++
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 399 --EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVL 456
+ + K++KMEK N L K++ + E + K + +S+ L E+A L
Sbjct: 482 TVDSVEGNASKILKMEK---ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
Query: 457 QESLEKESKVNKR----LSMENEEL 477
++++E + ++R L ENE L
Sbjct: 539 EKTIETLRENSERQIKILEQENEHL 563
Score = 58.9 bits (141), Expect = 1e-08
Identities = 86/384 (22%), Positives = 159/384 (41%), Gaps = 62/384 (16%)
Query: 151 ELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVN 210
E+++YK + + + ++++L E T++ L R + K H+ L +E +
Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHE-LEKENLQ 386
Query: 211 LRGEL----VTASTTCEKLEKARNELQTVYEAFVQQH--------QAEKTERENRLKEFY 258
L+ +L + +K+E+ E T+ A Q + E+ R + L E
Sbjct: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
Query: 259 TR----EYEKLRDTYIEEAEKYKMQLQEQFDNLNA--------AHETSKLEIEASH-SEK 305
+ E +L + + + E L + + L A + K+E E S+K
Sbjct: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506
Query: 306 LELLK------KAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEK 359
+E+L+ K + + K EK LE + +E+ E+QI L+ EN+ LN+
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 360 LKSEEQKRRAREKANLK----------------NPQIMYLEQELESLKAVLEIKNEK--- 400
+ S Q+ + +A +K + ++ +E E +K LE EK
Sbjct: 567 VSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER 626
Query: 401 -------LHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQ 453
LH + + ++K + N +K++ +QEN EL+ R ++ + +
Sbjct: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE-RENRKLKKTLDSFKNL 685
Query: 454 AVLQESLEKESKVNKRLSMENEEL 477
ESLEKE N +L EN EL
Sbjct: 686 TFQLESLEKE---NSQLDEENLEL 706
Score = 54.3 bits (129), Expect = 3e-07
Identities = 99/447 (22%), Positives = 184/447 (41%), Gaps = 93/447 (20%)
Query: 111 SRKNLFTALNAVEKSR-QKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQL 169
S KNL L ++EK Q + +L ++ K +L + E++ + +
Sbjct: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740
Query: 170 KQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKAR 229
+LL K E L V Q L E + K + ++++ L EL + L+K
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800
Query: 230 NELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNA 289
EL+ + + E+ E+EN+ E T + EK + ++ EK +L++Q + +
Sbjct: 801 EELK------ISSKRLEQLEKENKSLEQETSQLEKDK----KQLEKENKRLRQQAEIKDT 850
Query: 290 AHETSKLEIEASHSEKLELLK------------KAYEASLSEIKKGHEIEKKSL----ED 333
E + ++I E L K K E E+ K I+ K+L ED
Sbjct: 851 TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED 910
Query: 334 LLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELES-LKA 392
L+SEK ++ ++ NDL+ L EK+ ++ R ++ + + + LE +LES LK
Sbjct: 911 LVSEKLKT-QQMNNDLEKLTHEL-EKIGLNKE-RLLHDEQSTDDSRYKLLESKLESTLKK 967
Query: 393 VLEIKNEKLH----------------QQDIKLMKM-----------EKLVDNNTALVDKL 425
LEIK EK+ +Q++K +K E++V ++ + +
Sbjct: 968 SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED 1027
Query: 426 KRFQQENEELKARM----DKHMAISRQLSTEQAVLQE----------------------- 458
++++E++E + D+ + + R +T QA Q
Sbjct: 1028 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1087
Query: 459 ----SLEKESKV----NKRLSMENEEL 477
SL++++ N +L +EN L
Sbjct: 1088 RQTVSLQEQNTTLQTQNAKLQVENSTL 1114
Score = 44.7 bits (104), Expect = 2e-04
Identities = 82/387 (21%), Positives = 162/387 (41%), Gaps = 45/387 (11%)
Query: 148 KTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQE 207
+T+ L + T + Q+ + L N++ +L LL ++ +++++ +E
Sbjct: 1089 QTVSLQEQNTTLQTQNAKLQVENSTL---NSQSTSLMNQNAQLLIQQSSLENENESVIKE 1145
Query: 208 LVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRD 267
+L+ + EKLE + YE+ + +H K+ +N E+ L D
Sbjct: 1146 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN-----LEVEHRDLED 1200
Query: 268 TY---------IEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLS 318
Y +E+ EK QE+ N HET E + E + L Y L
Sbjct: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN-DRLNHTYSQLLK 1259
Query: 319 EIKKGHEIEKKSLEDLLSE---KQESLEKQINDLKSEN---DALNEKLKSEEQKRRAREK 372
E + + + K+L+ LL+ +Q LE + + LK + D + KL + + + ++ K
Sbjct: 1260 ETEV-LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL-NNQCELLSQLK 1317
Query: 373 ANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN 432
NL+ L+Q L ++N L +Q+++ + + +DKL +++
Sbjct: 1318 GNLEEENRHLLDQ-----IQTLMLQNRTLLEQNMESKDLFHV--EQRQYIDKLNELRRQK 1370
Query: 433 EELKAR-MDKHMAISRQLSTEQA-VLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPK 490
E+L+ + MD++ + + + K K K ++ E ++ L +P
Sbjct: 1371 EKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSL-------TLTPT 1423
Query: 491 RSPTSSA---IPLQSPRNSGSFPSPSI 514
RS +S +P Q ++S S S S+
Sbjct: 1424 RSDSSEGFLQLPHQDSQDSSSVGSNSL 1450
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 71.6 bits (174), Expect = 2e-12
Identities = 85/343 (24%), Positives = 146/343 (42%), Gaps = 79/343 (23%)
Query: 188 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEK 247
+ L +E K+++ L +++ NL+ TCEK+E E +
Sbjct: 628 EELENELHHLEKENELLQKKITNLK-------ITCEKIEALEQE-------------NSE 667
Query: 248 TERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE 307
ERENR + ++ L +E EK QL E+ NL L+ + +L+
Sbjct: 668 LERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEE--NLELRRNVESLKCASMKMAQLQ 724
Query: 308 LLKKAYEASLSEIKKGHE--------------------IEKKSLEDLL---SEKQESLEK 344
L K E+ ++KKG E IE + L+ L ++K + LE
Sbjct: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
Query: 345 QINDLKSENDALN---EKLKSEEQKRRAREKANLKNPQ--------IMYLEQELESLKAV 393
++ DL+ EN L E+LK ++ EK N Q LE+E + L+
Sbjct: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
Query: 394 LEIKNEKLHQQDIKLMKMEKLVDNNTALVD---------KLKRFQQENEEL--KARMD-- 440
EIK+ L + ++K+ +EK +N T + +LK ++EN+EL +A +D
Sbjct: 845 AEIKDTTLEENNVKIGNLEK--ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
Query: 441 -----KHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELL 478
+ +S +L T+Q + LEK + +++ + E LL
Sbjct: 903 TLVTLREDLVSEKLKTQQ--MNNDLEKLTHELEKIGLNKERLL 943
Score = 69.3 bits (168), Expect = 8e-12
Identities = 81/325 (24%), Positives = 146/325 (44%), Gaps = 43/325 (13%)
Query: 188 QHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQA-- 245
QHL E +A + + L QEL +L+ E++E LQ + ++
Sbjct: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Query: 246 ----------EKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHET-- 293
EK R ++L+ +R E+L D E YK +++E ++ ET
Sbjct: 307 MYRDELDALREKAVRVDKLESEVSRYKERLHD-----IEFYKARVEELKEDNQVLLETKT 361
Query: 294 ---SKLEIEASHSEKLELLKK---AYEASLSEIKKGHEIEKKSLEDLLSEKQ--ESLEKQ 345
+LE + S+KL L+K +A L +++ ++++K +E+L+ E E +KQ
Sbjct: 362 MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQ 421
Query: 346 IND------LKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESL-KAVLEIKN 398
D + E + +L QK E L + +++ LE E +SL K V E++
Sbjct: 422 SMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRT 481
Query: 399 --EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVL 456
+ + K++KMEK N L K++ + E + K + +S+ L E+A L
Sbjct: 482 TVDSVEGNASKILKMEK---ENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
Query: 457 QESLEKESKVNKR----LSMENEEL 477
++++E + ++R L ENE L
Sbjct: 539 EKTIETLRENSERQIKILEQENEHL 563
Score = 58.9 bits (141), Expect = 1e-08
Identities = 86/384 (22%), Positives = 159/384 (41%), Gaps = 62/384 (16%)
Query: 151 ELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVN 210
E+++YK + + + ++++L E T++ L R + K H+ L +E +
Sbjct: 328 EVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHE-LEKENLQ 386
Query: 211 LRGEL----VTASTTCEKLEKARNELQTVYEAFVQQH--------QAEKTERENRLKEFY 258
L+ +L + +K+E+ E T+ A Q + E+ R + L E
Sbjct: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
Query: 259 TR----EYEKLRDTYIEEAEKYKMQLQEQFDNLNA--------AHETSKLEIEASH-SEK 305
+ E +L + + + E L + + L A + K+E E S+K
Sbjct: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKK 506
Query: 306 LELLK------KAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEK 359
+E+L+ K + + K EK LE + +E+ E+QI L+ EN+ LN+
Sbjct: 507 VEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 360 LKSEEQKRRAREKANLK----------------NPQIMYLEQELESLKAVLEIKNEK--- 400
+ S Q+ + +A +K + ++ +E E +K LE EK
Sbjct: 567 VSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER 626
Query: 401 -------LHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQ 453
LH + + ++K + N +K++ +QEN EL+ R ++ + +
Sbjct: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE-RENRKLKKTLDSFKNL 685
Query: 454 AVLQESLEKESKVNKRLSMENEEL 477
ESLEKE N +L EN EL
Sbjct: 686 TFQLESLEKE---NSQLDEENLEL 706
Score = 55.5 bits (132), Expect = 1e-07
Identities = 83/383 (21%), Positives = 165/383 (43%), Gaps = 78/383 (20%)
Query: 150 LELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSERE---EALKQHKTLSQ 206
LE++ ENQ +L++ L N K + L +Q L E + + L++ K S+
Sbjct: 754 LEVSYQGLDIENQ-----RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKT------------EREN-- 252
L L E + +LEK + +L+ + QQ + + T E+EN
Sbjct: 809 RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT 868
Query: 253 -------------RLKEFYTREYEKLRDTYI---------EEAEKYKMQLQEQFDNLNA- 289
RLKE E ++ I E+ K++ Q+ ++L
Sbjct: 869 LSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
Query: 290 AHETSKLEI--------EASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQES 341
HE K+ + E S ++ +LL+ E++L KK EI+++ + L + +ES
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDRYKLLESKLESTL---KKSLEIKEEKIAALEARLEES 985
Query: 342 ------LEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE 395
L +++ +K +AL ++ ++++R + + + + E+ + +L+
Sbjct: 986 TNYNQQLRQELKTVKKNYEALKQR---QDEERMVQSSPPISGEDNKWERESQETTRELLK 1042
Query: 396 IKNEKLH-QQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQA 454
+K+ + +++ ++ EK AL +LK+ + +N L+A++ +A+ RQ +
Sbjct: 1043 VKDRLIEVERNNATLQAEK-----QALKTQLKQLETQNNNLQAQI---LALQRQTVS--- 1091
Query: 455 VLQESLEKESKVNKRLSMENEEL 477
LQE N +L +EN L
Sbjct: 1092 -LQEQNTTLQTQNAKLQVENSTL 1113
Score = 44.7 bits (104), Expect = 2e-04
Identities = 82/387 (21%), Positives = 162/387 (41%), Gaps = 45/387 (11%)
Query: 148 KTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQE 207
+T+ L + T + Q+ + L N++ +L LL ++ +++++ +E
Sbjct: 1088 QTVSLQEQNTTLQTQNAKLQVENSTL---NSQSTSLMNQNAQLLIQQSSLENENESVIKE 1144
Query: 208 LVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRD 267
+L+ + EKLE + YE+ + +H K+ +N E+ L D
Sbjct: 1145 REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN-----LEVEHRDLED 1199
Query: 268 TY---------IEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLS 318
Y +E+ EK QE+ N HET E + E + L Y L
Sbjct: 1200 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN-DRLNHTYSQLLK 1258
Query: 319 EIKKGHEIEKKSLEDLLSE---KQESLEKQINDLKSEN---DALNEKLKSEEQKRRAREK 372
E + + + K+L+ LL+ +Q LE + + LK + D + KL + + + ++ K
Sbjct: 1259 ETEV-LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKL-NNQCELLSQLK 1316
Query: 373 ANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN 432
NL+ L+Q L ++N L +Q+++ + + +DKL +++
Sbjct: 1317 GNLEEENRHLLDQ-----IQTLMLQNRTLLEQNMESKDLFHV--EQRQYIDKLNELRRQK 1369
Query: 433 EELKAR-MDKHMAISRQLSTEQA-VLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPK 490
E+L+ + MD++ + + + K K K ++ E ++ L +P
Sbjct: 1370 EKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSL-------TLTPT 1422
Query: 491 RSPTSSA---IPLQSPRNSGSFPSPSI 514
RS +S +P Q ++S S S S+
Sbjct: 1423 RSDSSEGFLQLPHQDSQDSSSVGSNSL 1449
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 71.2 bits (173), Expect = 2e-12
Identities = 80/349 (22%), Positives = 156/349 (44%), Gaps = 38/349 (10%)
Query: 152 LTQYKTKCE-NQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVN 210
L ++KTKCE +Q+ LK+ + F+ L + L + E +++K L QE+ +
Sbjct: 1454 LAEWKTKCEESQAELEASLKESRSLSTELFK-LKNAYEEALDQLETVKRENKNLEQEIAD 1512
Query: 211 LRGELVTASTTCEKLEKARNELQ----------TVYEAFVQQHQAEKTERENRLKEFYTR 260
L ++ T +LEK+R +++ EA ++ +A+ + L + +
Sbjct: 1513 LTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSE 1572
Query: 261 EYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEI 320
K+ + EE E+ K Q + + +A L+ E + LKK E L+EI
Sbjct: 1573 IDRKIAEK-DEEIEQLKRNYQRTVETMQSA-----LDAEVRSRNEAIRLKKKMEGDLNEI 1626
Query: 321 KKGHEIEKKSLEDLLSEKQESLEKQINDLKSE-NDALNEKLKSEEQKRRAREKANLKNPQ 379
+ + + L + S++ Q+ D + +DAL + +EQ +ANL
Sbjct: 1627 EIQLSHANRQAAETLKHLR-SVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANL---- 1681
Query: 380 IMYLEQELESLKAVLE--IKNEKLHQQDI--KLMKMEKLVDNNTALVDKLKRFQQENEEL 435
L+ E+E L+A LE + KL +Q++ +++ L NT+L+ K+ + + +L
Sbjct: 1682 ---LQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQL 1738
Query: 436 KARMDKHMAISRQLS-------TEQAVLQESLEKESKVNKRLSMENEEL 477
++ ++ +R T+ A++ E L+KE + L + L
Sbjct: 1739 QSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1787
Score = 58.5 bits (140), Expect = 1e-08
Identities = 64/301 (21%), Positives = 133/301 (44%), Gaps = 49/301 (16%)
Query: 224 KLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQ 283
K++ +T E + + +KT+ E E +E E+ T ++E ++Q+Q +
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAE 895
Query: 284 FDNLNAAHE------TSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIE------KKSL 331
+NL A E +K ++EA E E + E + K ++E KK +
Sbjct: 896 SENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 955
Query: 332 EDL------LSEKQESLEKQINDLKSENDALNEKLKSEEQKRRA---------------R 370
+DL + +++ + E ++ +L E L+E + ++++A
Sbjct: 956 DDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEE 1015
Query: 371 EKANLKNPQIMYLEQELESLKAVLE---------IKNEKLHQQDIKLMKMEKLVD---NN 418
+K N N LEQ++E L++ LE +N++ + D+KL + E ++D +
Sbjct: 1016 DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQ-ESILDLENDK 1074
Query: 419 TALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQ---ESLEKESKVNKRLSMENE 475
L ++LK+ E +L+++++ + Q + LQ E LE+E + + + E
Sbjct: 1075 QQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTE 1134
Query: 476 E 476
+
Sbjct: 1135 K 1135
Score = 56.2 bits (134), Expect = 7e-08
Identities = 75/350 (21%), Positives = 151/350 (43%), Gaps = 29/350 (8%)
Query: 147 EKTLELTQYKTK--CENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKT- 203
EK T+ K K E SG + +L EA + L +E ++ +KT
Sbjct: 966 EKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTK 1025
Query: 204 --LSQELVNLRGELVTASTTCEKLEKARNELQ---TVYEAFVQQHQAEKTERENRLKEFY 258
L Q++ +L L LE+ + +L+ + + + + +K + + RLK+
Sbjct: 1026 SKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKK-- 1083
Query: 259 TREYEKLR-DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSE--KLELLKKAYEA 315
+++E + + +E+ + +Q Q++ L A E + EIEA + K E + Y
Sbjct: 1084 -KDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYAR 1142
Query: 316 SLSEIKKGHE----IEKKSLEDLLSEKQES----LEKQINDLKSENDALNEKLKSEEQKR 367
L E+ + E + +E L++K+E+ L + + + +++A+ L+ +
Sbjct: 1143 ELEELSERLEEAGGVTSTQIE--LNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADS 1200
Query: 368 RAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMK--MEKLVDNNTALVDKL 425
A + N Q + + E E + LEI + + + K +EK+ L D+L
Sbjct: 1201 VAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKIC---RTLEDQL 1257
Query: 426 KRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENE 475
+ +NEE++ + + +L TE L LE++ + +LS +
Sbjct: 1258 SEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQ 1307
Score = 45.1 bits (105), Expect = 2e-04
Identities = 72/321 (22%), Positives = 127/321 (39%), Gaps = 51/321 (15%)
Query: 168 QLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEK 227
++KQ L ++F+ + I L S E K L + L +L A E++++
Sbjct: 1213 RVKQKLEKEKSEFK---LEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQR 1269
Query: 228 ARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNL 287
+ +EL T Q +A + R+ KE + + + + ++ E+ K QL+E+
Sbjct: 1270 SLSELTTQKSRL--QTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAK 1327
Query: 288 NA-AHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQI 346
NA AH S +LL++ YE E ++G K L+ LS+ + +
Sbjct: 1328 NALAHALQ------SSRHDCDLLREQYE----EEQEG----KAELQRALSKANSEVAQWR 1373
Query: 347 NDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDI 406
K E DA+ + EE K++ ++ L+ E++ +
Sbjct: 1374 T--KYETDAIQRTEELEEAKKKLAQR---------------------LQDSEEQVEAVNA 1410
Query: 407 KLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHM----AISRQLSTEQAVLQESLEK 462
K +EK V+ L + L A +DK + + T+ Q LE
Sbjct: 1411 KCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEA 1470
Query: 463 ESKVNKRLSMENEELLWKLHN 483
K ++ LS E L+KL N
Sbjct: 1471 SLKESRSLSTE----LFKLKN 1487
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 71.2 bits (173), Expect = 2e-12
Identities = 77/334 (23%), Positives = 139/334 (41%), Gaps = 43/334 (12%)
Query: 178 TKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 237
TK +L ++ L +EE + +K L E+ +L +LEK++ L+T
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--- 1539
Query: 238 AFVQQHQAEKTERENRLKEFYTREYEKLR----------------DTYIEEAEKYKMQLQ 281
Q + KT+ E E E KLR E+ E+ + QLQ
Sbjct: 1540 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 282 EQFDNLNAAHETSKLE--IEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQ 339
Q E + + + A+ +KLE K E KG E K L L ++ +
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 340 ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQEL---ESLKAVLEI 396
+ ++++ D ++ D + K E+K ++ E +M L+++L E + ++
Sbjct: 1656 D-FQRELEDARASRDEIFATAKENEKKAKSLEA------DLMQLQEDLAAAERARKQADL 1708
Query: 397 KNEKLHQQ-DIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMD-------KHMAISRQ 448
+ E+L ++ L L D L ++ + ++E EE + M+ K + Q
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 449 LSTEQAVLQESLEKESKVNKRLSMENEELLWKLH 482
LS E A + + +K ++L +N+EL KLH
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLH 1802
Score = 64.7 bits (156), Expect = 2e-10
Identities = 76/315 (24%), Positives = 141/315 (44%), Gaps = 40/315 (12%)
Query: 166 ILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKL 225
I +LK LA + +A + ++++ ALK+ + L + +L+ +L + K
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 226 EKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 285
EK + +L EA KTE E+ L T ++LR +E K L E+
Sbjct: 1138 EKQKRDLGEELEAL-------KTELEDTLDS--TATQQELRAKREQEVTVLKKALDEE-- 1186
Query: 286 NLNAAHETSKLEIEASH-------SEKLELLKKAYEASLSEIKKGHEIEKKSLED---LL 335
+HE E+ H +E+LE K+A +A+L + K+ E E L +L
Sbjct: 1187 --TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGELRVL 1243
Query: 336 SEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE 395
+ ++ +E + L+++ L K E R +A L N ++ L+ E+ES+ +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGE-----RARAEL-NDKVHKLQNEVESVTGM-- 1295
Query: 396 IKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAV 455
L++ + K +K+ K V + ++ + + QE K + + RQL E+
Sbjct: 1296 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL---RQLEEERNS 1347
Query: 456 LQESLEKESKVNKRL 470
LQ+ L++E + + L
Sbjct: 1348 LQDQLDEEMEAKQNL 1362
Score = 62.8 bits (151), Expect = 7e-10
Identities = 72/349 (20%), Positives = 153/349 (43%), Gaps = 27/349 (7%)
Query: 151 ELTQYKTKCENQSGFILQLKQLLACGNTKFEA----LTVVIQHLLSEREEALKQHKTLSQ 206
+L +Y+T+ E++ + + L A K E L + + REEA+KQ + L
Sbjct: 1597 QLHEYETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 266
++ + + EL A + +++ E + +A+ E + + E+ R
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKE---------NEKKAKSLEADLMQLQEDLAAAERAR 1703
Query: 267 DTYIEEAEKYKMQLQEQFDNLNAAH-ETSKLEIE-ASHSEKLELLKKAYEASLSEIKKGH 324
E E+ +L NA E +LE A E+LE + EA ++K
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763
Query: 325 EIEKKSLEDLLSEKQ--ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLK--NPQI 380
+ ++ +L +E+ + E L+ +N L KL E +++ K+ + +I
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 381 MYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN----EELK 436
LE+++E + + L Q+D KL ++ V++ + ++ K ++ ++LK
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 437 ARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGD 485
++++ S++++ + LQ L++ ++ N+ + E L KL G+
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1932
Score = 61.6 bits (148), Expect = 2e-09
Identities = 79/340 (23%), Positives = 142/340 (41%), Gaps = 42/340 (12%)
Query: 168 QLKQLLACGNTKFEALTVVIQHLLSEREEAL-----KQHKTLSQELVNLRGELVTASTTC 222
Q KQ + K EA +Q S+ E A K HK L E+ ++ G L A
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK-LQNEVESVTGMLNEAEGKA 1303
Query: 223 EKLEK----ARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKM 278
KL K ++LQ E +Q+ +K +L++ E L+D EE E K
Sbjct: 1304 IKLAKDVASLSSQLQDTQE-LLQEETRQKLNVSTKLRQL-EEERNSLQDQLDEEMEA-KQ 1360
Query: 279 QLQEQFDNLNAAHETSKLEIE--ASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLS 336
L+ LN SK +++ AS E LE KK ++ + + + +E EK + D L
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLE 1419
Query: 337 EKQESLEKQINDLKSENDALNEKLKSEEQKRRAREK--ANLKNPQIMYLEQE-------- 386
+ + L+++++DL + D + + + E+K+R ++ A KN Y ++
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 387 ---------LESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKA 437
+L+ LE K E + +ME LV + + + ++ L+
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 438 RMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 477
+M+ ++ T+ L++ L+ RL + + L
Sbjct: 1540 QME-------EMKTQLEELEDELQATEDAKLRLEVNMQAL 1572
Score = 60.8 bits (146), Expect = 3e-09
Identities = 79/327 (24%), Positives = 152/327 (46%), Gaps = 31/327 (9%)
Query: 167 LQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLE 226
LQL+++ A K + L I + + + K+ K L + + +L L + L
Sbjct: 969 LQLEKVTA--EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 227 KARNELQT-VYEAFVQQHQAEKTERE-----NRLKEFYTREYEKLRDTYIEEAEKYKMQL 280
K +N+ ++ + E V+ + EK+ +E +L+ + +E++ D + AE KMQL
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQL 1085
Query: 281 QEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK-- 338
++ + L AA ++L+ E + +K LKK E +GH + + EDL SE+
Sbjct: 1086 AKKEEELQAA--LARLDDEIA--QKNNALKKIREL------EGHISDLQ--EDLDSERAA 1133
Query: 339 QESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN 398
+ EKQ DL E +AL +L+ +++ K EQE+ LK L+ +
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR------EQEVTVLKKALD-EE 1186
Query: 399 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQE 458
+ H+ ++ M+ +K L ++L++F++ L + L+ E VL +
Sbjct: 1187 TRSHEAQVQEMR-QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245
Query: 459 SLEKESKVNKRLSMENEELLWKLHNGD 485
+ ++ K+L + +EL K +G+
Sbjct: 1246 AKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Score = 53.1 bits (126), Expect = 6e-07
Identities = 80/356 (22%), Positives = 156/356 (43%), Gaps = 47/356 (13%)
Query: 147 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 206
+K +LT+ K + Q +L + A ++ +L E E L++ + Q
Sbjct: 880 QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 939
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 266
+L R ++ E E+ E EA Q+ Q EK E ++K+ + +
Sbjct: 940 QLQAERKKMAQQMLDLE--EQLEEE-----EAARQKLQLEKVTAEAKIKKL--EDEILVM 990
Query: 267 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI 326
D + K + L+E+ +L T+ L E ++ L LK +E+ +SE++ +
Sbjct: 991 DDQNNKLSKERKLLEERISDL-----TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1045
Query: 327 EKKSLEDLLSEKQE------SLEKQINDLKSENDALNEKLKSEE---------------Q 365
E+KS ++L K++ +QI DL+++ L +L +E Q
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1105
Query: 366 KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKL 425
K A +K I L+++L+S +A K EK ++D+ E+L T L D L
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARN-KAEK-QKRDLG----EELEALKTELEDTL 1159
Query: 426 KRFQQENEELKARMDKHM-----AISRQLSTEQAVLQESLEKESKVNKRLSMENEE 476
+ +EL+A+ ++ + A+ + + +A +QE +K ++ + L+ + E+
Sbjct: 1160 DSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Score = 49.7 bits (117), Expect = 6e-06
Identities = 50/257 (19%), Positives = 122/257 (47%), Gaps = 16/257 (6%)
Query: 237 EAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 296
E ++ + +KT+ + E +E E+ EE + QLQ + + L A E ++
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-LYAEAEEMRV 911
Query: 297 EIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDAL 356
+ A E E+L + E +G +++ + + ++++ LE+Q+ + ++ L
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK--MAQQMLDLEEQLEEEEAARQKL 969
Query: 357 N-EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLV 415
EK+ +E + ++ ++ + + Q L +E + L+ + L +++ K + KL
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 416 DNNTALVDKL-------KRFQQENEELKARMDKHMA-ISRQLSTEQAVLQE----SLEKE 463
+ + +++ +L ++ +QE E+LK +++ + Q++ QA + E +KE
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 464 SKVNKRLSMENEELLWK 480
++ L+ ++E+ K
Sbjct: 1090 EELQAALARLDDEIAQK 1106
Score = 38.9 bits (89), Expect = 0.011
Identities = 40/160 (25%), Positives = 67/160 (41%), Gaps = 14/160 (8%)
Query: 337 EKQESLEKQINDLKSENDALNEKLKSEEQKR-RAREKANLKNPQIMY---LEQELESLKA 392
E+ ++ E ++ K +LK EQK + E+ NL Q+ L E E ++
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 393 VLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 452
L K ++L E L + L ++ R QQ E K + + + QL E
Sbjct: 912 RLAAKKQELE---------EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 453 QAVLQE-SLEKESKVNKRLSMENEELLWKLHNGDLCSPKR 491
+A Q+ LEK + K +E+E L+ N L ++
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Score = 34.7 bits (78), Expect = 0.22
Identities = 41/170 (24%), Positives = 78/170 (45%), Gaps = 24/170 (14%)
Query: 192 SEREEALKQHKTLSQELVNLRGELVTA-STTCEKLEKARNELQTVYEAFVQQHQAEKTER 250
S R++ +Q+K L +L + G + + +T LE +L E V+Q EK
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL----EEQVEQEAREKQAA 1840
Query: 251 ENRLKEFYTREYEKLRDTYIEEAEKYKM--QLQEQFDNLNAAHETSKLEIEASHSEKLEL 308
LK+ + +KL++ ++ ++ KM Q +EQ + NA + K ++E + E +
Sbjct: 1841 TKSLKQ----KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1896
Query: 309 LKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNE 358
+ + K E+ D +E E++ +++N LKS+ NE
Sbjct: 1897 -------NANRRKLQREL------DEATESNEAMGREVNALKSKLRRGNE 1933
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 71.2 bits (173), Expect = 2e-12
Identities = 77/334 (23%), Positives = 139/334 (41%), Gaps = 43/334 (12%)
Query: 178 TKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 237
TK +L ++ L +EE + +K L E+ +L +LEK++ L+T
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--- 1546
Query: 238 AFVQQHQAEKTERENRLKEFYTREYEKLR----------------DTYIEEAEKYKMQLQ 281
Q + KT+ E E E KLR E+ E+ + QLQ
Sbjct: 1547 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 282 EQFDNLNAAHETSKLE--IEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQ 339
Q E + + + A+ +KLE K E KG E K L L ++ +
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 340 ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQEL---ESLKAVLEI 396
+ ++++ D ++ D + K E+K ++ E +M L+++L E + ++
Sbjct: 1663 D-FQRELEDARASRDEIFATAKENEKKAKSLEA------DLMQLQEDLAAAERARKQADL 1715
Query: 397 KNEKLHQQ-DIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMD-------KHMAISRQ 448
+ E+L ++ L L D L ++ + ++E EE + M+ K + Q
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 449 LSTEQAVLQESLEKESKVNKRLSMENEELLWKLH 482
LS E A + + +K ++L +N+EL KLH
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLH 1809
Score = 64.7 bits (156), Expect = 2e-10
Identities = 76/315 (24%), Positives = 141/315 (44%), Gaps = 40/315 (12%)
Query: 166 ILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKL 225
I +LK LA + +A + ++++ ALK+ + L + +L+ +L + K
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 226 EKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 285
EK + +L EA KTE E+ L T ++LR +E K L E+
Sbjct: 1145 EKQKRDLGEELEAL-------KTELEDTLDS--TATQQELRAKREQEVTVLKKALDEE-- 1193
Query: 286 NLNAAHETSKLEIEASH-------SEKLELLKKAYEASLSEIKKGHEIEKKSLED---LL 335
+HE E+ H +E+LE K+A +A+L + K+ E E L +L
Sbjct: 1194 --TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGELRVL 1250
Query: 336 SEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE 395
+ ++ +E + L+++ L K E R +A L N ++ L+ E+ES+ +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGE-----RARAEL-NDKVHKLQNEVESVTGM-- 1302
Query: 396 IKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAV 455
L++ + K +K+ K V + ++ + + QE K + + RQL E+
Sbjct: 1303 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL---RQLEEERNS 1354
Query: 456 LQESLEKESKVNKRL 470
LQ+ L++E + + L
Sbjct: 1355 LQDQLDEEMEAKQNL 1369
Score = 62.8 bits (151), Expect = 7e-10
Identities = 72/349 (20%), Positives = 153/349 (43%), Gaps = 27/349 (7%)
Query: 151 ELTQYKTKCENQSGFILQLKQLLACGNTKFEA----LTVVIQHLLSEREEALKQHKTLSQ 206
+L +Y+T+ E++ + + L A K E L + + REEA+KQ + L
Sbjct: 1604 QLHEYETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 266
++ + + EL A + +++ E + +A+ E + + E+ R
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKE---------NEKKAKSLEADLMQLQEDLAAAERAR 1710
Query: 267 DTYIEEAEKYKMQLQEQFDNLNAAH-ETSKLEIE-ASHSEKLELLKKAYEASLSEIKKGH 324
E E+ +L NA E +LE A E+LE + EA ++K
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770
Query: 325 EIEKKSLEDLLSEKQ--ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLK--NPQI 380
+ ++ +L +E+ + E L+ +N L KL E +++ K+ + +I
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 381 MYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN----EELK 436
LE+++E + + L Q+D KL ++ V++ + ++ K ++ ++LK
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 437 ARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGD 485
++++ S++++ + LQ L++ ++ N+ + E L KL G+
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939
Score = 61.6 bits (148), Expect = 2e-09
Identities = 79/340 (23%), Positives = 142/340 (41%), Gaps = 42/340 (12%)
Query: 168 QLKQLLACGNTKFEALTVVIQHLLSEREEAL-----KQHKTLSQELVNLRGELVTASTTC 222
Q KQ + K EA +Q S+ E A K HK L E+ ++ G L A
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK-LQNEVESVTGMLNEAEGKA 1310
Query: 223 EKLEK----ARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKM 278
KL K ++LQ E +Q+ +K +L++ E L+D EE E K
Sbjct: 1311 IKLAKDVASLSSQLQDTQE-LLQEETRQKLNVSTKLRQL-EEERNSLQDQLDEEMEA-KQ 1367
Query: 279 QLQEQFDNLNAAHETSKLEIE--ASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLS 336
L+ LN SK +++ AS E LE KK ++ + + + +E EK + D L
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLE 1426
Query: 337 EKQESLEKQINDLKSENDALNEKLKSEEQKRRAREK--ANLKNPQIMYLEQE-------- 386
+ + L+++++DL + D + + + E+K+R ++ A KN Y ++
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 387 ---------LESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKA 437
+L+ LE K E + +ME LV + + + ++ L+
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 438 RMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 477
+M+ ++ T+ L++ L+ RL + + L
Sbjct: 1547 QME-------EMKTQLEELEDELQATEDAKLRLEVNMQAL 1579
Score = 60.8 bits (146), Expect = 3e-09
Identities = 79/327 (24%), Positives = 152/327 (46%), Gaps = 31/327 (9%)
Query: 167 LQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLE 226
LQL+++ A K + L I + + + K+ K L + + +L L + L
Sbjct: 976 LQLEKVTA--EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 227 KARNELQT-VYEAFVQQHQAEKTERE-----NRLKEFYTREYEKLRDTYIEEAEKYKMQL 280
K +N+ ++ + E V+ + EK+ +E +L+ + +E++ D + AE KMQL
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQL 1092
Query: 281 QEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK-- 338
++ + L AA ++L+ E + +K LKK E +GH + + EDL SE+
Sbjct: 1093 AKKEEELQAA--LARLDDEIA--QKNNALKKIREL------EGHISDLQ--EDLDSERAA 1140
Query: 339 QESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN 398
+ EKQ DL E +AL +L+ +++ K EQE+ LK L+ +
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR------EQEVTVLKKALD-EE 1193
Query: 399 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQE 458
+ H+ ++ M+ +K L ++L++F++ L + L+ E VL +
Sbjct: 1194 TRSHEAQVQEMR-QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252
Query: 459 SLEKESKVNKRLSMENEELLWKLHNGD 485
+ ++ K+L + +EL K +G+
Sbjct: 1253 AKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Score = 53.1 bits (126), Expect = 6e-07
Identities = 80/356 (22%), Positives = 156/356 (43%), Gaps = 47/356 (13%)
Query: 147 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 206
+K +LT+ K + Q +L + A ++ +L E E L++ + Q
Sbjct: 887 QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 946
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 266
+L R ++ E E+ E EA Q+ Q EK E ++K+ + +
Sbjct: 947 QLQAERKKMAQQMLDLE--EQLEEE-----EAARQKLQLEKVTAEAKIKKL--EDEILVM 997
Query: 267 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI 326
D + K + L+E+ +L T+ L E ++ L LK +E+ +SE++ +
Sbjct: 998 DDQNNKLSKERKLLEERISDL-----TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1052
Query: 327 EKKSLEDLLSEKQE------SLEKQINDLKSENDALNEKLKSEE---------------Q 365
E+KS ++L K++ +QI DL+++ L +L +E Q
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1112
Query: 366 KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKL 425
K A +K I L+++L+S +A K EK ++D+ E+L T L D L
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARN-KAEK-QKRDLG----EELEALKTELEDTL 1166
Query: 426 KRFQQENEELKARMDKHM-----AISRQLSTEQAVLQESLEKESKVNKRLSMENEE 476
+ +EL+A+ ++ + A+ + + +A +QE +K ++ + L+ + E+
Sbjct: 1167 DSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Score = 49.7 bits (117), Expect = 6e-06
Identities = 50/257 (19%), Positives = 122/257 (47%), Gaps = 16/257 (6%)
Query: 237 EAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 296
E ++ + +KT+ + E +E E+ EE + QLQ + + L A E ++
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-LYAEAEEMRV 918
Query: 297 EIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDAL 356
+ A E E+L + E +G +++ + + ++++ LE+Q+ + ++ L
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK--MAQQMLDLEEQLEEEEAARQKL 976
Query: 357 N-EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLV 415
EK+ +E + ++ ++ + + Q L +E + L+ + L +++ K + KL
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 416 DNNTALVDKL-------KRFQQENEELKARMDKHMA-ISRQLSTEQAVLQE----SLEKE 463
+ + +++ +L ++ +QE E+LK +++ + Q++ QA + E +KE
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 464 SKVNKRLSMENEELLWK 480
++ L+ ++E+ K
Sbjct: 1097 EELQAALARLDDEIAQK 1113
Score = 38.9 bits (89), Expect = 0.011
Identities = 40/160 (25%), Positives = 67/160 (41%), Gaps = 14/160 (8%)
Query: 337 EKQESLEKQINDLKSENDALNEKLKSEEQKR-RAREKANLKNPQIMY---LEQELESLKA 392
E+ ++ E ++ K +LK EQK + E+ NL Q+ L E E ++
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 393 VLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 452
L K ++L E L + L ++ R QQ E K + + + QL E
Sbjct: 919 RLAAKKQELE---------EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 453 QAVLQE-SLEKESKVNKRLSMENEELLWKLHNGDLCSPKR 491
+A Q+ LEK + K +E+E L+ N L ++
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Score = 34.7 bits (78), Expect = 0.22
Identities = 41/170 (24%), Positives = 78/170 (45%), Gaps = 24/170 (14%)
Query: 192 SEREEALKQHKTLSQELVNLRGELVTA-STTCEKLEKARNELQTVYEAFVQQHQAEKTER 250
S R++ +Q+K L +L + G + + +T LE +L E V+Q EK
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQL----EEQVEQEAREKQAA 1847
Query: 251 ENRLKEFYTREYEKLRDTYIEEAEKYKM--QLQEQFDNLNAAHETSKLEIEASHSEKLEL 308
LK+ + +KL++ ++ ++ KM Q +EQ + NA + K ++E + E +
Sbjct: 1848 TKSLKQ----KDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRI 1903
Query: 309 LKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNE 358
+ + K E+ D +E E++ +++N LKS+ NE
Sbjct: 1904 -------NANRRKLQREL------DEATESNEAMGREVNALKSKLRRGNE 1940
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 71.2 bits (173), Expect = 2e-12
Identities = 77/334 (23%), Positives = 139/334 (41%), Gaps = 43/334 (12%)
Query: 178 TKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 237
TK +L ++ L +EE + +K L E+ +L +LEK++ L+T
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--- 1546
Query: 238 AFVQQHQAEKTERENRLKEFYTREYEKLR----------------DTYIEEAEKYKMQLQ 281
Q + KT+ E E E KLR E+ E+ + QLQ
Sbjct: 1547 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1602
Query: 282 EQFDNLNAAHETSKLE--IEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQ 339
Q E + + + A+ +KLE K E KG E K L L ++ +
Sbjct: 1603 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1662
Query: 340 ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQEL---ESLKAVLEI 396
+ ++++ D ++ D + K E+K ++ E +M L+++L E + ++
Sbjct: 1663 D-FQRELEDARASRDEIFATAKENEKKAKSLEA------DLMQLQEDLAAAERARKQADL 1715
Query: 397 KNEKLHQQ-DIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMD-------KHMAISRQ 448
+ E+L ++ L L D L ++ + ++E EE + M+ K + Q
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 449 LSTEQAVLQESLEKESKVNKRLSMENEELLWKLH 482
LS E A + + +K ++L +N+EL KLH
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLH 1809
Score = 64.7 bits (156), Expect = 2e-10
Identities = 76/315 (24%), Positives = 141/315 (44%), Gaps = 40/315 (12%)
Query: 166 ILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKL 225
I +LK LA + +A + ++++ ALK+ + L + +L+ +L + K
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 226 EKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 285
EK + +L EA KTE E+ L T ++LR +E K L E+
Sbjct: 1145 EKQKRDLGEELEAL-------KTELEDTLDS--TATQQELRAKREQEVTVLKKALDEE-- 1193
Query: 286 NLNAAHETSKLEIEASH-------SEKLELLKKAYEASLSEIKKGHEIEKKSLED---LL 335
+HE E+ H +E+LE K+A +A+L + K+ E E L +L
Sbjct: 1194 --TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGELRVL 1250
Query: 336 SEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE 395
+ ++ +E + L+++ L K E R +A L N ++ L+ E+ES+ +
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGE-----RARAEL-NDKVHKLQNEVESVTGM-- 1302
Query: 396 IKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAV 455
L++ + K +K+ K V + ++ + + QE K + + RQL E+
Sbjct: 1303 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL---RQLEEERNS 1354
Query: 456 LQESLEKESKVNKRL 470
LQ+ L++E + + L
Sbjct: 1355 LQDQLDEEMEAKQNL 1369
Score = 61.6 bits (148), Expect = 2e-09
Identities = 79/340 (23%), Positives = 142/340 (41%), Gaps = 42/340 (12%)
Query: 168 QLKQLLACGNTKFEALTVVIQHLLSEREEAL-----KQHKTLSQELVNLRGELVTASTTC 222
Q KQ + K EA +Q S+ E A K HK L E+ ++ G L A
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK-LQNEVESVTGMLNEAEGKA 1310
Query: 223 EKLEK----ARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKM 278
KL K ++LQ E +Q+ +K +L++ E L+D EE E K
Sbjct: 1311 IKLAKDVASLSSQLQDTQE-LLQEETRQKLNVSTKLRQL-EEERNSLQDQLDEEMEA-KQ 1367
Query: 279 QLQEQFDNLNAAHETSKLEIE--ASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLS 336
L+ LN SK +++ AS E LE KK ++ + + + +E EK + D L
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLE 1426
Query: 337 EKQESLEKQINDLKSENDALNEKLKSEEQKRRAREK--ANLKNPQIMYLEQE-------- 386
+ + L+++++DL + D + + + E+K+R ++ A KN Y ++
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 387 ---------LESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKA 437
+L+ LE K E + +ME LV + + + ++ L+
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 438 RMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 477
+M+ ++ T+ L++ L+ RL + + L
Sbjct: 1547 QME-------EMKTQLEELEDELQATEDAKLRLEVNMQAL 1579
Score = 60.8 bits (146), Expect = 3e-09
Identities = 79/327 (24%), Positives = 152/327 (46%), Gaps = 31/327 (9%)
Query: 167 LQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLE 226
LQL+++ A K + L I + + + K+ K L + + +L L + L
Sbjct: 976 LQLEKVTA--EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 227 KARNELQT-VYEAFVQQHQAEKTERE-----NRLKEFYTREYEKLRDTYIEEAEKYKMQL 280
K +N+ ++ + E V+ + EK+ +E +L+ + +E++ D + AE KMQL
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQL 1092
Query: 281 QEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK-- 338
++ + L AA ++L+ E + +K LKK E +GH + + EDL SE+
Sbjct: 1093 AKKEEELQAA--LARLDDEIA--QKNNALKKIREL------EGHISDLQ--EDLDSERAA 1140
Query: 339 QESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN 398
+ EKQ DL E +AL +L+ +++ K EQE+ LK L+ +
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR------EQEVTVLKKALD-EE 1193
Query: 399 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQE 458
+ H+ ++ M+ +K L ++L++F++ L + L+ E VL +
Sbjct: 1194 TRSHEAQVQEMR-QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1252
Query: 459 SLEKESKVNKRLSMENEELLWKLHNGD 485
+ ++ K+L + +EL K +G+
Sbjct: 1253 AKQEVEHKKKKLEAQVQELQSKCSDGE 1279
Score = 60.1 bits (144), Expect = 5e-09
Identities = 71/345 (20%), Positives = 151/345 (43%), Gaps = 27/345 (7%)
Query: 151 ELTQYKTKCENQSGFILQLKQLLACGNTKFEA----LTVVIQHLLSEREEALKQHKTLSQ 206
+L +Y+T+ E++ + + L A K E L + + REEA+KQ + L
Sbjct: 1604 QLHEYETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 266
++ + + EL A + +++ E + +A+ E + + E+ R
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKE---------NEKKAKSLEADLMQLQEDLAAAERAR 1710
Query: 267 DTYIEEAEKYKMQLQEQFDNLNAAH-ETSKLEIE-ASHSEKLELLKKAYEASLSEIKKGH 324
E E+ +L NA E +LE A E+LE + EA ++K
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770
Query: 325 EIEKKSLEDLLSEKQ--ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLK--NPQI 380
+ ++ +L +E+ + E L+ +N L KL E +++ K+ + +I
Sbjct: 1771 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1830
Query: 381 MYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN----EELK 436
LE+++E + + L Q+D KL ++ V++ + ++ K ++ ++LK
Sbjct: 1831 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 437 ARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 481
++++ S++++ + LQ L++ ++ N+ + E L KL
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 53.1 bits (126), Expect = 6e-07
Identities = 80/356 (22%), Positives = 156/356 (43%), Gaps = 47/356 (13%)
Query: 147 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 206
+K +LT+ K + Q +L + A ++ +L E E L++ + Q
Sbjct: 887 QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 946
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 266
+L R ++ E E+ E EA Q+ Q EK E ++K+ + +
Sbjct: 947 QLQAERKKMAQQMLDLE--EQLEEE-----EAARQKLQLEKVTAEAKIKKL--EDEILVM 997
Query: 267 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI 326
D + K + L+E+ +L T+ L E ++ L LK +E+ +SE++ +
Sbjct: 998 DDQNNKLSKERKLLEERISDL-----TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1052
Query: 327 EKKSLEDLLSEKQE------SLEKQINDLKSENDALNEKLKSEE---------------Q 365
E+KS ++L K++ +QI DL+++ L +L +E Q
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1112
Query: 366 KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKL 425
K A +K I L+++L+S +A K EK ++D+ E+L T L D L
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARN-KAEK-QKRDLG----EELEALKTELEDTL 1166
Query: 426 KRFQQENEELKARMDKHM-----AISRQLSTEQAVLQESLEKESKVNKRLSMENEE 476
+ +EL+A+ ++ + A+ + + +A +QE +K ++ + L+ + E+
Sbjct: 1167 DSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Score = 49.7 bits (117), Expect = 6e-06
Identities = 50/257 (19%), Positives = 122/257 (47%), Gaps = 16/257 (6%)
Query: 237 EAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 296
E ++ + +KT+ + E +E E+ EE + QLQ + + L A E ++
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-LYAEAEEMRV 918
Query: 297 EIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDAL 356
+ A E E+L + E +G +++ + + ++++ LE+Q+ + ++ L
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK--MAQQMLDLEEQLEEEEAARQKL 976
Query: 357 N-EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLV 415
EK+ +E + ++ ++ + + Q L +E + L+ + L +++ K + KL
Sbjct: 977 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036
Query: 416 DNNTALVDKL-------KRFQQENEELKARMDKHMA-ISRQLSTEQAVLQE----SLEKE 463
+ + +++ +L ++ +QE E+LK +++ + Q++ QA + E +KE
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 464 SKVNKRLSMENEELLWK 480
++ L+ ++E+ K
Sbjct: 1097 EELQAALARLDDEIAQK 1113
Score = 38.9 bits (89), Expect = 0.011
Identities = 40/160 (25%), Positives = 67/160 (41%), Gaps = 14/160 (8%)
Query: 337 EKQESLEKQINDLKSENDALNEKLKSEEQKR-RAREKANLKNPQIMY---LEQELESLKA 392
E+ ++ E ++ K +LK EQK + E+ NL Q+ L E E ++
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 393 VLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 452
L K ++L E L + L ++ R QQ E K + + + QL E
Sbjct: 919 RLAAKKQELE---------EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 453 QAVLQE-SLEKESKVNKRLSMENEELLWKLHNGDLCSPKR 491
+A Q+ LEK + K +E+E L+ N L ++
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 71.2 bits (173), Expect = 2e-12
Identities = 77/334 (23%), Positives = 139/334 (41%), Gaps = 43/334 (12%)
Query: 178 TKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 237
TK +L ++ L +EE + +K L E+ +L +LEK++ L+T
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET--- 1539
Query: 238 AFVQQHQAEKTERENRLKEFYTREYEKLR----------------DTYIEEAEKYKMQLQ 281
Q + KT+ E E E KLR E+ E+ + QLQ
Sbjct: 1540 ----QMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ 1595
Query: 282 EQFDNLNAAHETSKLE--IEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQ 339
Q E + + + A+ +KLE K E KG E K L L ++ +
Sbjct: 1596 RQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMK 1655
Query: 340 ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQEL---ESLKAVLEI 396
+ ++++ D ++ D + K E+K ++ E +M L+++L E + ++
Sbjct: 1656 D-FQRELEDARASRDEIFATAKENEKKAKSLEA------DLMQLQEDLAAAERARKQADL 1708
Query: 397 KNEKLHQQ-DIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMD-------KHMAISRQ 448
+ E+L ++ L L D L ++ + ++E EE + M+ K + Q
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 449 LSTEQAVLQESLEKESKVNKRLSMENEELLWKLH 482
LS E A + + +K ++L +N+EL KLH
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLH 1802
Score = 64.7 bits (156), Expect = 2e-10
Identities = 76/315 (24%), Positives = 141/315 (44%), Gaps = 40/315 (12%)
Query: 166 ILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKL 225
I +LK LA + +A + ++++ ALK+ + L + +L+ +L + K
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 226 EKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFD 285
EK + +L EA KTE E+ L T ++LR +E K L E+
Sbjct: 1138 EKQKRDLGEELEAL-------KTELEDTLDS--TATQQELRAKREQEVTVLKKALDEE-- 1186
Query: 286 NLNAAHETSKLEIEASH-------SEKLELLKKAYEASLSEIKKGHEIEKKSLED---LL 335
+HE E+ H +E+LE K+A +A+L + K+ E E L +L
Sbjct: 1187 --TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA-KANLDKNKQTLEKENADLAGELRVL 1243
Query: 336 SEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE 395
+ ++ +E + L+++ L K E R +A L N ++ L+ E+ES+ +
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGE-----RARAEL-NDKVHKLQNEVESVTGM-- 1295
Query: 396 IKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAV 455
L++ + K +K+ K V + ++ + + QE K + + RQL E+
Sbjct: 1296 -----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKL---RQLEEERNS 1347
Query: 456 LQESLEKESKVNKRL 470
LQ+ L++E + + L
Sbjct: 1348 LQDQLDEEMEAKQNL 1362
Score = 61.6 bits (148), Expect = 2e-09
Identities = 79/340 (23%), Positives = 142/340 (41%), Gaps = 42/340 (12%)
Query: 168 QLKQLLACGNTKFEALTVVIQHLLSEREEAL-----KQHKTLSQELVNLRGELVTASTTC 222
Q KQ + K EA +Q S+ E A K HK L E+ ++ G L A
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK-LQNEVESVTGMLNEAEGKA 1303
Query: 223 EKLEK----ARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKM 278
KL K ++LQ E +Q+ +K +L++ E L+D EE E K
Sbjct: 1304 IKLAKDVASLSSQLQDTQE-LLQEETRQKLNVSTKLRQL-EEERNSLQDQLDEEMEA-KQ 1360
Query: 279 QLQEQFDNLNAAHETSKLEIE--ASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLS 336
L+ LN SK +++ AS E LE KK ++ + + + +E EK + D L
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE-EKAAAYDKLE 1419
Query: 337 EKQESLEKQINDLKSENDALNEKLKSEEQKRRAREK--ANLKNPQIMYLEQE-------- 386
+ + L+++++DL + D + + + E+K+R ++ A KN Y ++
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 387 ---------LESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKA 437
+L+ LE K E + +ME LV + + + ++ L+
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 438 RMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 477
+M+ ++ T+ L++ L+ RL + + L
Sbjct: 1540 QME-------EMKTQLEELEDELQATEDAKLRLEVNMQAL 1572
Score = 60.8 bits (146), Expect = 3e-09
Identities = 79/327 (24%), Positives = 152/327 (46%), Gaps = 31/327 (9%)
Query: 167 LQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLE 226
LQL+++ A K + L I + + + K+ K L + + +L L + L
Sbjct: 969 LQLEKVTA--EAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 227 KARNELQT-VYEAFVQQHQAEKTERE-----NRLKEFYTREYEKLRDTYIEEAEKYKMQL 280
K +N+ ++ + E V+ + EK+ +E +L+ + +E++ D + AE KMQL
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE-LKMQL 1085
Query: 281 QEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK-- 338
++ + L AA ++L+ E + +K LKK E +GH + + EDL SE+
Sbjct: 1086 AKKEEELQAA--LARLDDEIA--QKNNALKKIREL------EGHISDLQ--EDLDSERAA 1133
Query: 339 QESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN 398
+ EKQ DL E +AL +L+ +++ K EQE+ LK L+ +
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR------EQEVTVLKKALD-EE 1186
Query: 399 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQE 458
+ H+ ++ M+ +K L ++L++F++ L + L+ E VL +
Sbjct: 1187 TRSHEAQVQEMR-QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQ 1245
Query: 459 SLEKESKVNKRLSMENEELLWKLHNGD 485
+ ++ K+L + +EL K +G+
Sbjct: 1246 AKQEVEHKKKKLEAQVQELQSKCSDGE 1272
Score = 60.1 bits (144), Expect = 5e-09
Identities = 71/345 (20%), Positives = 151/345 (43%), Gaps = 27/345 (7%)
Query: 151 ELTQYKTKCENQSGFILQLKQLLACGNTKFEA----LTVVIQHLLSEREEALKQHKTLSQ 206
+L +Y+T+ E++ + + L A K E L + + REEA+KQ + L
Sbjct: 1597 QLHEYETELEDER----KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 266
++ + + EL A + +++ E + +A+ E + + E+ R
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKE---------NEKKAKSLEADLMQLQEDLAAAERAR 1703
Query: 267 DTYIEEAEKYKMQLQEQFDNLNAAH-ETSKLEIE-ASHSEKLELLKKAYEASLSEIKKGH 324
E E+ +L NA E +LE A E+LE + EA ++K
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763
Query: 325 EIEKKSLEDLLSEKQ--ESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLK--NPQI 380
+ ++ +L +E+ + E L+ +N L KL E +++ K+ + +I
Sbjct: 1764 QQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKI 1823
Query: 381 MYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQEN----EELK 436
LE+++E + + L Q+D KL ++ V++ + ++ K ++ ++LK
Sbjct: 1824 AQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 437 ARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 481
++++ S++++ + LQ L++ ++ N+ + E L KL
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Score = 53.1 bits (126), Expect = 6e-07
Identities = 80/356 (22%), Positives = 156/356 (43%), Gaps = 47/356 (13%)
Query: 147 EKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQ 206
+K +LT+ K + Q +L + A ++ +L E E L++ + Q
Sbjct: 880 QKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ 939
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLR 266
+L R ++ E E+ E EA Q+ Q EK E ++K+ + +
Sbjct: 940 QLQAERKKMAQQMLDLE--EQLEEE-----EAARQKLQLEKVTAEAKIKKL--EDEILVM 990
Query: 267 DTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEI 326
D + K + L+E+ +L T+ L E ++ L LK +E+ +SE++ +
Sbjct: 991 DDQNNKLSKERKLLEERISDL-----TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1045
Query: 327 EKKSLEDLLSEKQE------SLEKQINDLKSENDALNEKLKSEE---------------Q 365
E+KS ++L K++ +QI DL+++ L +L +E Q
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1105
Query: 366 KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKL 425
K A +K I L+++L+S +A K EK ++D+ E+L T L D L
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARN-KAEK-QKRDLG----EELEALKTELEDTL 1159
Query: 426 KRFQQENEELKARMDKHM-----AISRQLSTEQAVLQESLEKESKVNKRLSMENEE 476
+ +EL+A+ ++ + A+ + + +A +QE +K ++ + L+ + E+
Sbjct: 1160 DSTATQ-QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Score = 49.7 bits (117), Expect = 6e-06
Identities = 50/257 (19%), Positives = 122/257 (47%), Gaps = 16/257 (6%)
Query: 237 EAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 296
E ++ + +KT+ + E +E E+ EE + QLQ + + L A E ++
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETE-LYAEAEEMRV 911
Query: 297 EIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDAL 356
+ A E E+L + E +G +++ + + ++++ LE+Q+ + ++ L
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKK--MAQQMLDLEEQLEEEEAARQKL 969
Query: 357 N-EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLV 415
EK+ +E + ++ ++ + + Q L +E + L+ + L +++ K + KL
Sbjct: 970 QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029
Query: 416 DNNTALVDKL-------KRFQQENEELKARMDKHMA-ISRQLSTEQAVLQE----SLEKE 463
+ + +++ +L ++ +QE E+LK +++ + Q++ QA + E +KE
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 464 SKVNKRLSMENEELLWK 480
++ L+ ++E+ K
Sbjct: 1090 EELQAALARLDDEIAQK 1106
Score = 38.9 bits (89), Expect = 0.011
Identities = 40/160 (25%), Positives = 67/160 (41%), Gaps = 14/160 (8%)
Query: 337 EKQESLEKQINDLKSENDALNEKLKSEEQKR-RAREKANLKNPQIMY---LEQELESLKA 392
E+ ++ E ++ K +LK EQK + E+ NL Q+ L E E ++
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 393 VLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTE 452
L K ++L E L + L ++ R QQ E K + + + QL E
Sbjct: 912 RLAAKKQELE---------EILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 453 QAVLQE-SLEKESKVNKRLSMENEELLWKLHNGDLCSPKR 491
+A Q+ LEK + K +E+E L+ N L ++
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 70.9 bits (172), Expect = 3e-12
Identities = 88/357 (24%), Positives = 167/357 (46%), Gaps = 51/357 (14%)
Query: 143 ALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHK 202
AL + L++ Q K EN + L Q LA + E L IQ L +RE +
Sbjct: 1404 ALQEQGELKVAQGKALQEN----LALLTQTLAEREEEVETLRGQIQELEKQREMQKAALE 1459
Query: 203 TLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREY 262
LS +L E+ ++LEK R+ L+ + A ++ Q +RE RE
Sbjct: 1460 LLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQ------IREL 1513
Query: 263 EKLRDTYIEEAEKYKMQLQEQFDNLNAAH-------------ETSKLEIEASHSEKLELL 309
EK R+T E ++L+++ + + E LE+E +H K+E
Sbjct: 1514 EKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENH-HKMECQ 1572
Query: 310 KKAYEASLSEIKKGHEIEKKSLEDL---LSEKQESLE---KQINDLKSENDALNEKLKSE 363
+K + E++ E ++ +L L L E+ + L+ QI+DL+S + L +L+
Sbjct: 1573 QKL----IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQER 1628
Query: 364 EQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVD 423
+Q+ +++ + QI L+++ E L LE ++++L Q ++ +E D T
Sbjct: 1629 DQEVKSQRE------QIEELQRQKEHLTQDLERRDQELMLQKERIQVLE---DQRTR--- 1676
Query: 424 KLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNK--RLSMENEELL 478
+ K +++ E++K + + R+L+T++ ++QE E+ +K R S+E+ +L+
Sbjct: 1677 QTKILEEDLEQIKLSLRER---GRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730
Score = 67.4 bits (163), Expect = 3e-11
Identities = 81/331 (24%), Positives = 139/331 (41%), Gaps = 59/331 (17%)
Query: 181 EALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFV 240
+AL +Q L ER+ TL+ + V+L+GE+ + S E L+KAR EL+ E
Sbjct: 431 KALRQRLQKLTGERD-------TLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLE 483
Query: 241 QQ-----------------HQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQ 283
Q+ Q +K E++ L RE E+L++ + K L E
Sbjct: 484 QEAWRLRRVNVELQLQGDSAQGQKEEQQEEL-HLAVRERERLQEMLMGLEAKQSESLSEL 542
Query: 284 FDNLNAAHETSKLEIEASHSEKLEL---LKKAYEASLSEIKKGHEIEKKSLEDL------ 334
L A E+S LE E E+ E+ L +A E S++E+ K + DL
Sbjct: 543 I-TLREALESSHLEGELLRQEQTEVTAALARA-EQSIAELSSSENTLKTEVADLRAAAVK 600
Query: 335 -------LSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQEL 387
L+ + L +Q+ L+ EN ++ ++++ EQ R A + E
Sbjct: 601 LSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNA----------LQVDLAEA 650
Query: 388 ESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISR 447
E + L KN L Q ++K + L L+ Q+E EE++ ++ +
Sbjct: 651 EKRREALWEKNTHLEAQ------LQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQE 704
Query: 448 QLSTEQAVLQESLEKESKVNKRLSMENEELL 478
+T+ L + +++ +V R E E L+
Sbjct: 705 AATTQLEQLHQEAKRQEEVLARAVQEKEALV 735
Score = 61.2 bits (147), Expect = 2e-09
Identities = 75/304 (24%), Positives = 141/304 (46%), Gaps = 25/304 (8%)
Query: 150 LELTQYKTKCENQ-SGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQEL 208
LEL +++ E + QL Q G T E + +++ E ++ ++ Q+
Sbjct: 813 LELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQ- 871
Query: 209 VNLRGELVTASTTCEK----LEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEK 264
EL A + E+ LE E QT EA Q + E+T+ E+ L + E EK
Sbjct: 872 -----ELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQL-ETEK 925
Query: 265 LRDTYIE---EAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK 321
R + +E + +K +Q + L + KL+ + + L++A + L E
Sbjct: 926 ERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEA-QRELKEAA 984
Query: 322 KGHEIEKKSLED----LLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKN 377
+ H + +L++ LL +K + L+KQ+ DLKS+ A ++ + EQ+ +EK +
Sbjct: 985 RQHRDDLAALQEESSSLLQDKMD-LQKQVEDLKSQLVAQDDSQRLVEQE--VQEKLR-ET 1040
Query: 378 PQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNN-TALVDKLKRFQQENEELK 436
+ +++ELE KA L + + Q+ + L + + + +AL ++ Q E +EL
Sbjct: 1041 QEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELS 1100
Query: 437 ARMD 440
A+M+
Sbjct: 1101 AQME 1104
Score = 49.7 bits (117), Expect = 6e-06
Identities = 64/318 (20%), Positives = 142/318 (44%), Gaps = 21/318 (6%)
Query: 162 QSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTT 221
Q QL+QL + E L +Q E+E +++ L L + + +
Sbjct: 703 QEAATTQLEQLHQEAKRQEEVLARAVQ----EKEALVREKAALEVRLQAVERDRQDLAEQ 758
Query: 222 CEKLEKARNELQT-VYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQL 280
+ L A+ L++ ++EA Q E T+ + E + + ++ E K++L
Sbjct: 759 LQGLSSAKELLESSLFEAQQQNSVIEVTKGQ---LEVQIQTVTQAKEVIQGEVRCLKLEL 815
Query: 281 QEQFDNLNAAHETSKLEIEASHSE---KLELLKKAYEASLSEIKKGHEIEKKSLEDLLSE 337
+ + + ++ + E LE K A+E ++++++ E E+ + L++
Sbjct: 816 DTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAK 875
Query: 338 KQESLEKQINDLK---SENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVL 394
ESLE++ +L+ E E ++++ ++ R + ++ L Q+ ++ + L+ +L
Sbjct: 876 ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLL 935
Query: 395 EIKNE--KLHQQDIKL---MKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQL 449
+ + E QQ +L MK++KL + T + + + Q+ ELK +H L
Sbjct: 936 QTQKELADASQQLERLRQDMKVQKLKEQETTGILQ-TQLQEAQRELKEAARQHRDDLAAL 994
Query: 450 STE-QAVLQESLEKESKV 466
E ++LQ+ ++ + +V
Sbjct: 995 QEESSSLLQDKMDLQKQV 1012
Score = 49.7 bits (117), Expect = 6e-06
Identities = 86/413 (20%), Positives = 168/413 (40%), Gaps = 58/413 (14%)
Query: 151 ELTQYKTKCENQ-SGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELV 209
EL + K + E Q G ++ + + + + + V+ Q L RE+ + ++L +L
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD 1806
Query: 210 NLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTY 269
+ L E L++ + + Q E ++ A + E R E L+D +
Sbjct: 1807 EAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGE-LQD-H 1864
Query: 270 IEEAEKYKMQLQEQFDNLNAAHET-SKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEK 328
E+A + + +L + + A E L E+ EK L A + +E + HE+E
Sbjct: 1865 KEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALL---ALQQQCAEQAQEHEVET 1921
Query: 329 KSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKA----------NLKNP 378
++L+D + Q L+++ +L++ A ++ + +E+ RAR +A L+
Sbjct: 1922 RALQDSWLQAQAVLKERDQELEALR-AESQSSRHQEEAARARAEALQEALGKAHAALQGK 1980
Query: 379 QIMYLEQ-----ELES------------------LKAVLEIKNEKLHQQDIKLMKMEKLV 415
+ LEQ LE+ L+ L I+ ++ QD++ + + +
Sbjct: 1981 EQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQL 2040
Query: 416 DNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKE--------SKVN 467
A D+ R QQE E+L + + +Q + QE E+E ++
Sbjct: 2041 QQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100
Query: 468 KRLSMENEELLWKLHNGDLCSPKRSPTSSAIP---LQSPRNSGSFPSPSISPR 517
L+ + +E+L +L ++ A+P SP S S+ PR
Sbjct: 2101 LTLAQKEQEIL------ELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPR 2147
Score = 43.5 bits (101), Expect = 5e-04
Identities = 61/278 (21%), Positives = 121/278 (43%), Gaps = 24/278 (8%)
Query: 123 EKSRQKNPRSLC-IQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFE 181
E+ R + +LC +Q +T + + +TL TQ + +Q + +L+Q + K +
Sbjct: 906 EEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ--LERLRQDMKVQKLKEQ 963
Query: 182 ALTVVIQHLLSERE----EALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYE 237
T ++Q L E + EA +QH+ +L L+ E + L+K +L++
Sbjct: 964 ETTGILQTQLQEAQRELKEAARQHR---DDLAALQEESSSLLQDKMDLQKQVEDLKSQLV 1020
Query: 238 AFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLE 297
A + + E + +L+E T+EY +++ E + L E+ L E +
Sbjct: 1021 AQDDSQRLVEQEVQEKLRE--TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIR 1078
Query: 298 IEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALN 357
++L L++ + + +G + E + +LL +QE EK+ + L E L
Sbjct: 1079 -----QQELSALRQDMQEA-----QGEQKELSAQMELL--RQEVKEKEADFLAQEAQLLE 1126
Query: 358 EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLE 395
E S +++ R + + L+ L S ++ LE
Sbjct: 1127 ELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLE 1164
Score = 42.7 bits (99), Expect = 8e-04
Identities = 59/280 (21%), Positives = 125/280 (44%), Gaps = 43/280 (15%)
Query: 212 RGELVTASTTCEKLEKARNEL-QTVYEAFVQQHQAEKTERENRLKEFYT-REYEKLR-DT 268
RG L+TA + E + A ++L Q +++ QQ + ++ +L+E T E EK + T
Sbjct: 1229 RGPLLTA-LSAEAVASALHKLHQDLWKT--QQTRDVLRDQVQKLEERLTDTEAEKSQVHT 1285
Query: 269 YIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEK 328
+++ ++ Q QE+ + + E+ H L + A L + E
Sbjct: 1286 ELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM------EA 1339
Query: 329 KSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELE 388
+ +LL +E+L Q+ E L++ + RA+ A LE++L
Sbjct: 1340 QGERELLQAAKENLTAQV-----------EHLQAAVVEARAQASA------AGILEEDLR 1382
Query: 389 SLKAVLEIKNEKL-----------HQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKA 437
+ ++ L++KNE++ Q ++K+ + + L +N L L ++E E L+
Sbjct: 1383 TARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRG 1442
Query: 438 RMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 477
++ + + +Q ++A L+ K N+ + ++ E++
Sbjct: 1443 QIQE---LEKQREMQKAALELLSLDLKKRNQEVDLQQEQI 1479
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 69.7 bits (169), Expect = 6e-12
Identities = 86/348 (24%), Positives = 156/348 (44%), Gaps = 60/348 (17%)
Query: 142 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 201
D EKTL ++ + + ++ I +L+Q L C + + + L Q + ERE +Q
Sbjct: 1925 DGYADEKTL----FERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 202 KTLSQELVNLRGELV--TASTTCEKLE------KARNELQTVYEA-----------FVQQ 242
+ + E + +L+ T EKLE K R++LQ +A F++
Sbjct: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
Query: 243 HQAEKTE-----RENRLKEFYTREYEKL-----------RDTYIEEAEKYKMQLQ--EQF 284
Q + TE ++N+ E + K RD + +E +K + QL+ +F
Sbjct: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
Query: 285 DNLNAAHETSKLEIEASHSEKL-----ELLKKAYEASLSEIKKGHEIEK-----KSLEDL 334
++ H+T ++E A+H ++ ELL + ++ EIEK + LE
Sbjct: 2101 QPISE-HQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQA 2159
Query: 335 LSEKQESLEKQINDLKSENDA-LNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAV 393
L ++ +K + D K +L E Q + R+ + K +I LE++LE +
Sbjct: 2160 LLVSADTFQK-VEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREE 2218
Query: 394 LEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 441
LE KNE++ Q ++L +K ++ T +L+ +QEN+ K M+K
Sbjct: 2219 LENKNEEVQQLHMQLEIQKK--ESTT----RLQELEQENKLFKDDMEK 2260
Score = 63.9 bits (154), Expect = 3e-10
Identities = 92/420 (21%), Positives = 174/420 (41%), Gaps = 53/420 (12%)
Query: 98 AHVHLMKTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKT 157
A + MKT KG L + N Q ++ I K + K
Sbjct: 458 AQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNI-------KLQDTNSQKE 510
Query: 158 KCENQSGFIL--------QLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELV 209
K + + G IL QL+ L+ + E + Q + + + + HK+LS +
Sbjct: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST-VE 569
Query: 210 NLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRD-- 267
+L+ E+V+AS + ++LE T Y+ ++ + EK +R+ E E E+LR
Sbjct: 570 DLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQL 629
Query: 268 --TYIEEAEKYKMQLQEQF--------DNLNAAHETS--------KLEIEASHSEKLELL 309
++ EE K K L+ + DNL ++ +IE EK L+
Sbjct: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLI 689
Query: 310 KKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKS----EEQ 365
K + L EI K +++ + L++ K E + QIN+L+ E + L ++ K E++
Sbjct: 690 TKQNQLIL-EISKLKDLQ----QSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE 744
Query: 366 KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKL-----VDNNTA 420
+ + K L Q+ E +L+ A LE +N L + L M K+ +
Sbjct: 745 VQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLI 804
Query: 421 LVDKLKRFQQEN---EELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 477
+D +K +++ +E++ ++++ + +Q +++ S K + +EL
Sbjct: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864
Score = 50.1 bits (118), Expect = 5e-06
Identities = 70/297 (23%), Positives = 142/297 (47%), Gaps = 39/297 (13%)
Query: 191 LSEREEALKQHKT--LSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKT 248
+ E E A KQH+ L++EL +R VT T E L++ + +EA ++Q T
Sbjct: 159 MMESELAGKQHEIEELNRELEEMR---VTYGT--EGLQQLQE-----FEAAIKQRDGIIT 208
Query: 249 ERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLEL 308
+ L++ + E +R+ ++E E+ +LQ QF L A+ ET + ++HS
Sbjct: 209 QLTANLQQARREKDETMRE-FLELTEQ-SQKLQIQFQQLQAS-ETLR---NSTHSSTAAD 262
Query: 309 LKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRR 368
L +A + L+ H+ + + + LL + Q+ E D + L EK+K E ++
Sbjct: 263 LLQAKQQILT-----HQQQLEEQDHLLEDYQKKKE----DFTMQISFLQEKIKVYEMEQD 313
Query: 369 AREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKM-EKLVDNNTALVDKLKR 427
+ + + K +E++ + ++E N K+ +++ K +++ +KL + L + ++
Sbjct: 314 KKVENSNK--------EEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQ 365
Query: 428 FQQENEE---LKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 481
Q+N+E +K + RQ S E L ++E+ K N + S +++ ++
Sbjct: 366 IVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422
Score = 47.8 bits (112), Expect = 2e-05
Identities = 61/285 (21%), Positives = 128/285 (44%), Gaps = 32/285 (11%)
Query: 193 EREEALKQHKTLSQEL---VNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTE 249
E E+LK + L + L R +L + E + + +T++E +Q EKT+
Sbjct: 1888 EATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQ----EKTD 1943
Query: 250 RENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLE-- 307
+RL++ +L +E E + Q+QE+ + L+ E K E + L+
Sbjct: 1944 IIDRLEQELLCASNRL-----QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQET 1998
Query: 308 --LLKKAYEASLSEIKKGHEIEKK------SLEDLLS---EKQESLEKQINDLKSENDAL 356
L+K+ E K +++K+ +E+ +S E ++ ++ DL+ +N AL
Sbjct: 1999 EKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQAL 2058
Query: 357 NEKLKS-----EEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKM 411
++L+ +EQ + ++ +I LEQ+L+ + I + + + +
Sbjct: 2059 EKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 2118
Query: 412 EKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVL 456
++ D + L+ ++ Q++ +E ++K R+L EQA+L
Sbjct: 2119 KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVREL--EQALL 2161
Score = 44.7 bits (104), Expect = 2e-04
Identities = 65/325 (20%), Positives = 139/325 (42%), Gaps = 28/325 (8%)
Query: 172 LLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNE 231
LL C + + V Q + ++A ++L E+ L ++ T ++ +++
Sbjct: 3060 LLNCLEQRIQEQGVEYQAAMECLQKA--DRRSLLSEIQALHAQMNGRKITLKREQESEKP 3117
Query: 232 LQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAH 291
Q + E +QQ Q++ E + L R E E+ KM + E L +
Sbjct: 3118 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ-----EQLSSEKMVVAE----LKSEL 3168
Query: 292 ETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQE-------SLEK 344
+KLE+E + + + LK+ EA E+K + E L D L+ +Q+ +LEK
Sbjct: 3169 AQTKLELETTLKAQHKHLKEL-EAFRLEVKDKTD-EVHLLNDTLASEQKKSRELQWALEK 3226
Query: 345 QINDLKSENDALNEKLKS-----EEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNE 399
+ L + E+L+ E QK+R + L Q L + + +++ + +
Sbjct: 3227 EKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA 3286
Query: 400 KLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQ---LSTEQAVL 456
+L ++ + ++++ L+++ + ++ EL A++ + L +E +
Sbjct: 3287 QLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK 3346
Query: 457 QESLEKESKVNKRLSMENEELLWKL 481
+ + E K ++ + + NE +KL
Sbjct: 3347 ELQKQLEEKHSRIVELLNETEKYKL 3371
Score = 42.4 bits (98), Expect = 0.001
Identities = 67/307 (21%), Positives = 132/307 (42%), Gaps = 31/307 (10%)
Query: 179 KFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEA 238
+ EA +++ E+ LK H +SQE + + + + + EK L E
Sbjct: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 239 FVQQ--HQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 296
QQ E+ E++ F + +E Y E E+Y L+ + D E SK
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLLKVKDDL-----EDSKN 883
Query: 297 EIEASHSEKLELLKKAYEA-----SLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKS 351
+ E + KL+ L + + ++K E K+ E E +EK +L
Sbjct: 884 KQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELME 943
Query: 352 ENDALN-EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMK 410
+ + EKL+ ++ E+ K+ +I +L +E++SLK ++ Q ++ +
Sbjct: 944 KLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK-------QEKEQVSLRCRE 996
Query: 411 MEKLVDNNTALVDKLKRFQQENEELKARMDKHMAI-SRQLSTEQAVLQESLEKESK--VN 467
+E ++++N A + Q + ++ + +D + + SR + + +S +ESK V
Sbjct: 997 LEIIINHNRA-----ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVE 1051
Query: 468 KRLSMEN 474
++S EN
Sbjct: 1052 DKVSFEN 1058
Score = 40.8 bits (94), Expect = 0.003
Identities = 54/272 (19%), Positives = 118/272 (43%), Gaps = 27/272 (9%)
Query: 151 ELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQH---LLSEREEALKQH-KTLSQ 206
EL ++ + ++++ + L LA K L ++ L EE K+ + L
Sbjct: 3188 ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKF 3247
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTR-EYEKL 265
L + + + + E+ ++ NE Q E+ + A+ +E + R E E EK+
Sbjct: 3248 SLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKV 3307
Query: 266 RDTYIEEAEKYKMQLQEQFDNLNAAHETS------------KLEIEASHSEKLELLKKAY 313
R + + +L Q + + ++ + ++E HS +ELL +
Sbjct: 3308 RIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE 3367
Query: 314 EASL------SEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKR 367
+ L +++K ++ +K+L+ E +K++++L+S+ + L +L E+KR
Sbjct: 3368 KYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEG-QKKMHELQSKVEDLQRQL---EEKR 3423
Query: 368 RAREKANLKNPQIMYLEQELESLKAVLEIKNE 399
+ K +L+ ++ + QE + + E K E
Sbjct: 3424 QQVYKLDLEGQRLQGIMQEFQKQELEREEKRE 3455
Score = 38.1 bits (87), Expect = 0.019
Identities = 57/246 (23%), Positives = 108/246 (43%), Gaps = 38/246 (15%)
Query: 178 TKFEALTVVIQHLLSEREEALKQH----KTLSQELVNLRGELVTASTTCEKLEKARNELQ 233
TK E L + LS+ E LKQ L++E+ +L+ E S C +LE N +
Sbjct: 948 TKREKLE--LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
Query: 234 TVYEAFVQQHQAEKTERENRLKEFYTREYE----KLRDTYIEEAEKYKMQLQEQFDNLNA 289
VQ + + + + +R E K+ ++ EE+ K ++ + F+N+
Sbjct: 1006 AEN---VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEES-KIMVEDKVSFENMTV 1061
Query: 290 AHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDL 349
E+ + ++ H L + K + SL + + L+K++N L
Sbjct: 1062 GEESKQEQLILDH--------------LPSVTK-----ESSLRATQPSENDKLQKELNVL 1102
Query: 350 KSENDALNEKLKSEEQKRRAREKANLKNPQIM-YLEQELESLKAVLEIKNEKLHQQDIKL 408
KSE + L +L+ E Q+ + Q+ Y+E E + KA+ +K E + Q+ K+
Sbjct: 1103 KSEQNDL--RLQMEAQRICLSLVYSTHVDQVREYMENEKD--KALCSLKEELIFAQEEKI 1158
Query: 409 MKMEKL 414
+++K+
Sbjct: 1159 KELQKI 1164
Score = 34.7 bits (78), Expect = 0.22
Identities = 57/282 (20%), Positives = 125/282 (44%), Gaps = 35/282 (12%)
Query: 169 LKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNL----------RGELVTA 218
+K +L N K LT + L ERE ++++ +++ + VN+ E+V
Sbjct: 2412 MKNVLKETNFKMNQLTQELFSLKRERE-SVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2470
Query: 219 STTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKM 278
+ LE QT +++F + + E RL + + K D + + K
Sbjct: 2471 EDALKSLEN-----QTYFKSFEENGKGSIINLETRLLQLESTVSAK--DLELTQCYKQIK 2523
Query: 279 QLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK 338
+QEQ ET L+ + + +K+ + +K A +S+I+ E ++ + +
Sbjct: 2524 DMQEQ-----GQFETEMLQKKIVNLQKI-VEEKVAAALVSQIQL--EAVQEYAKFCQDNQ 2575
Query: 339 QESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN 398
S E + ++++ N ++L S+ R + Q++ + L K +EI
Sbjct: 2576 TISSEPERTNIQNLNQLREDELGSDISALTLR--ISELESQVVEMHTSLILEKEQVEIAE 2633
Query: 399 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMD 440
+ + +++ KL++++KL++ N ++ Q+E E+ ++ D
Sbjct: 2634 KNVLEKEKKLLELQKLLEGN-------EKKQREKEKKRSPQD 2668
Score = 34.3 bits (77), Expect = 0.28
Identities = 49/243 (20%), Positives = 112/243 (46%), Gaps = 24/243 (9%)
Query: 199 KQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKT--ERENRLKE 256
++ K LS+EL E++ +++ + ++++ + T+ E + +KT R++ E
Sbjct: 1512 EEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE---EMFSKDKTFIVRQSIHDE 1568
Query: 257 FYTREYEKLRDTYI--EEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYE 314
+ R + E+ E + +L Q+ H+ + + +H ++E ++ E
Sbjct: 1569 ISVSSMDASRQLMLNEEQLEDMRQELVRQYQE----HQQATELLRQAHMRQMERQREDQE 1624
Query: 315 ASLSEIKK-GHEIEKKSL---EDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAR 370
EIK+ ++ ++S E+L+SE++ L +++ LK + A EKL E + +
Sbjct: 1625 QLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ 1684
Query: 371 EKANLKN----PQIMYLEQELESL-----KAVLEIKNEKLHQQDIKLMKMEKLVDNNTAL 421
+ +N + + E+EL+ +L + L + + +L+K+ V TA
Sbjct: 1685 TQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAA 1744
Query: 422 VDK 424
V++
Sbjct: 1745 VEE 1747
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 69.7 bits (169), Expect = 6e-12
Identities = 85/347 (24%), Positives = 158/347 (45%), Gaps = 66/347 (19%)
Query: 142 DALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQH 201
D EKTL ++ + + ++ I +L+Q L C + + + L Q + ERE +Q
Sbjct: 1925 DGYADEKTL----FERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQK 1980
Query: 202 KTLSQELVNLRGELV--TASTTCEKLE------KARNELQTVYEA-----------FVQQ 242
+ + E + +L+ T EKLE K R++LQ +A F++
Sbjct: 1981 EAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIEL 2040
Query: 243 HQAEKTE-----RENRLKEFYTREYEKL-----------RDTYIEEAEKYKMQLQ--EQF 284
Q + TE ++N+ E + K RD + +E +K + QL+ +F
Sbjct: 2041 EQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRF 2100
Query: 285 DNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEK 344
++ H+T ++E A+H + E K E LS+ + +I++++ E+ E LE
Sbjct: 2101 QPISE-HQTREVEQLANHLK--EKTDKCSELLLSKEQLQRDIQERN------EEIEKLEF 2151
Query: 345 QINDLKSENDALNEK----------LKSEEQKRRAREKANLKNPQIMYLEQELESLKAVL 394
++ +L+ + K L E Q + R+ + K +I LE++LE + L
Sbjct: 2152 RVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREEL 2211
Query: 395 EIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDK 441
E KNE++ Q ++L +K ++ T +L+ +QEN+ K M+K
Sbjct: 2212 ENKNEEVQQLHMQLEIQKK--ESTT----RLQELEQENKLFKDDMEK 2252
Score = 63.9 bits (154), Expect = 3e-10
Identities = 92/420 (21%), Positives = 174/420 (41%), Gaps = 53/420 (12%)
Query: 98 AHVHLMKTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKT 157
A + MKT KG L + N Q ++ I K + K
Sbjct: 458 AQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNI-------KLQDTNSQKE 510
Query: 158 KCENQSGFIL--------QLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELV 209
K + + G IL QL+ L+ + E + Q + + + + HK+LS +
Sbjct: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLST-VE 569
Query: 210 NLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRD-- 267
+L+ E+V+AS + ++LE T Y+ ++ + EK +R+ E E E+LR
Sbjct: 570 DLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQL 629
Query: 268 --TYIEEAEKYKMQLQEQF--------DNLNAAHETS--------KLEIEASHSEKLELL 309
++ EE K K L+ + DNL ++ +IE EK L+
Sbjct: 630 LFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLI 689
Query: 310 KKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKS----EEQ 365
K + L EI K +++ + L++ K E + QIN+L+ E + L ++ K E++
Sbjct: 690 TKQNQLIL-EISKLKDLQ----QSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQE 744
Query: 366 KRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKL-----VDNNTA 420
+ + K L Q+ E +L+ A LE +N L + L M K+ +
Sbjct: 745 VQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLI 804
Query: 421 LVDKLKRFQQEN---EELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEEL 477
+D +K +++ +E++ ++++ + +Q +++ S K + +EL
Sbjct: 805 FLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQEL 864
Score = 50.1 bits (118), Expect = 5e-06
Identities = 70/297 (23%), Positives = 142/297 (47%), Gaps = 39/297 (13%)
Query: 191 LSEREEALKQHKT--LSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKT 248
+ E E A KQH+ L++EL +R VT T E L++ + +EA ++Q T
Sbjct: 159 MMESELAGKQHEIEELNRELEEMR---VTYGT--EGLQQLQE-----FEAAIKQRDGIIT 208
Query: 249 ERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLEL 308
+ L++ + E +R+ ++E E+ +LQ QF L A+ ET + ++HS
Sbjct: 209 QLTANLQQARREKDETMRE-FLELTEQ-SQKLQIQFQQLQAS-ETLR---NSTHSSTAAD 262
Query: 309 LKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRR 368
L +A + L+ H+ + + + LL + Q+ E D + L EK+K E ++
Sbjct: 263 LLQAKQQILT-----HQQQLEEQDHLLEDYQKKKE----DFTMQISFLQEKIKVYEMEQD 313
Query: 369 AREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKM-EKLVDNNTALVDKLKR 427
+ + + K +E++ + ++E N K+ +++ K +++ +KL + L + ++
Sbjct: 314 KKVENSNK--------EEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGELQEQ 365
Query: 428 FQQENEE---LKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKL 481
Q+N+E +K + RQ S E L ++E+ K N + S +++ ++
Sbjct: 366 IVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422
Score = 44.7 bits (104), Expect = 2e-04
Identities = 65/325 (20%), Positives = 139/325 (42%), Gaps = 28/325 (8%)
Query: 172 LLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNE 231
LL C + + V Q + ++A ++L E+ L ++ T ++ +++
Sbjct: 3052 LLNCLEQRIQEQGVEYQAAMECLQKA--DRRSLLSEIQALHAQMNGRKITLKREQESEKP 3109
Query: 232 LQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAH 291
Q + E +QQ Q++ E + L R E E+ KM + E L +
Sbjct: 3110 SQELLEYNIQQKQSQMLEMQVELSSMKDRATELQ-----EQLSSEKMVVAE----LKSEL 3160
Query: 292 ETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQE-------SLEK 344
+KLE+E + + + LK+ EA E+K + E L D L+ +Q+ +LEK
Sbjct: 3161 AQTKLELETTLKAQHKHLKEL-EAFRLEVKDKTD-EVHLLNDTLASEQKKSRELQWALEK 3218
Query: 345 QINDLKSENDALNEKLKS-----EEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNE 399
+ L + E+L+ E QK+R + L Q L + + +++ + +
Sbjct: 3219 EKAKLGRSEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDA 3278
Query: 400 KLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQ---LSTEQAVL 456
+L ++ + ++++ L+++ + ++ EL A++ + L +E +
Sbjct: 3279 QLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLK 3338
Query: 457 QESLEKESKVNKRLSMENEELLWKL 481
+ + E K ++ + + NE +KL
Sbjct: 3339 ELQKQLEEKHSRIVELLNETEKYKL 3363
Score = 42.4 bits (98), Expect = 0.001
Identities = 67/307 (21%), Positives = 132/307 (42%), Gaps = 31/307 (10%)
Query: 179 KFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEA 238
+ EA +++ E+ LK H +SQE + + + + + EK L E
Sbjct: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 239 FVQQ--HQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKL 296
QQ E+ E++ F + +E Y E E+Y L+ + D E SK
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFAEKNFEV---NYQELQEEYACLLKVKDDL-----EDSKN 883
Query: 297 EIEASHSEKLELLKKAYEA-----SLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKS 351
+ E + KL+ L + + ++K E K+ E E +EK +L
Sbjct: 884 KQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELME 943
Query: 352 ENDALN-EKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMK 410
+ + EKL+ ++ E+ K+ +I +L +E++SLK ++ Q ++ +
Sbjct: 944 KLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK-------QEKEQVSLRCRE 996
Query: 411 MEKLVDNNTALVDKLKRFQQENEELKARMDKHMAI-SRQLSTEQAVLQESLEKESK--VN 467
+E ++++N A + Q + ++ + +D + + SR + + +S +ESK V
Sbjct: 997 LEIIINHNRA-----ENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVE 1051
Query: 468 KRLSMEN 474
++S EN
Sbjct: 1052 DKVSFEN 1058
Score = 40.8 bits (94), Expect = 0.003
Identities = 54/272 (19%), Positives = 118/272 (43%), Gaps = 27/272 (9%)
Query: 151 ELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQH---LLSEREEALKQH-KTLSQ 206
EL ++ + ++++ + L LA K L ++ L EE K+ + L
Sbjct: 3180 ELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKF 3239
Query: 207 ELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTR-EYEKL 265
L + + + + E+ ++ NE Q E+ + A+ +E + R E E EK+
Sbjct: 3240 SLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKV 3299
Query: 266 RDTYIEEAEKYKMQLQEQFDNLNAAHETS------------KLEIEASHSEKLELLKKAY 313
R + + +L Q + + ++ + ++E HS +ELL +
Sbjct: 3300 RIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETE 3359
Query: 314 EASL------SEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKR 367
+ L +++K ++ +K+L+ E +K++++L+S+ + L +L E+KR
Sbjct: 3360 KYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEG-QKKMHELQSKVEDLQRQL---EEKR 3415
Query: 368 RAREKANLKNPQIMYLEQELESLKAVLEIKNE 399
+ K +L+ ++ + QE + + E K E
Sbjct: 3416 QQVYKLDLEGQRLQGIMQEFQKQELEREEKRE 3447
Score = 38.1 bits (87), Expect = 0.019
Identities = 57/246 (23%), Positives = 108/246 (43%), Gaps = 38/246 (15%)
Query: 178 TKFEALTVVIQHLLSEREEALKQH----KTLSQELVNLRGELVTASTTCEKLEKARNELQ 233
TK E L + LS+ E LKQ L++E+ +L+ E S C +LE N +
Sbjct: 948 TKREKLE--LSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
Query: 234 TVYEAFVQQHQAEKTERENRLKEFYTREYE----KLRDTYIEEAEKYKMQLQEQFDNLNA 289
VQ + + + + +R E K+ ++ EE+ K ++ + F+N+
Sbjct: 1006 AEN---VQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEES-KIMVEDKVSFENMTV 1061
Query: 290 AHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDL 349
E+ + ++ H L + K + SL + + L+K++N L
Sbjct: 1062 GEESKQEQLILDH--------------LPSVTK-----ESSLRATQPSENDKLQKELNVL 1102
Query: 350 KSENDALNEKLKSEEQKRRAREKANLKNPQIM-YLEQELESLKAVLEIKNEKLHQQDIKL 408
KSE + L +L+ E Q+ + Q+ Y+E E + KA+ +K E + Q+ K+
Sbjct: 1103 KSEQNDL--RLQMEAQRICLSLVYSTHVDQVREYMENEKD--KALCSLKEELIFAQEEKI 1158
Query: 409 MKMEKL 414
+++K+
Sbjct: 1159 KELQKI 1164
Score = 34.7 bits (78), Expect = 0.22
Identities = 57/282 (20%), Positives = 125/282 (44%), Gaps = 35/282 (12%)
Query: 169 LKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNL----------RGELVTA 218
+K +L N K LT + L ERE ++++ +++ + VN+ E+V
Sbjct: 2404 MKNVLKETNFKMNQLTQELFSLKRERE-SVEKIQSIPENSVNVAIDHLSKDKPELEVVLT 2462
Query: 219 STTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKM 278
+ LE QT +++F + + E RL + + K D + + K
Sbjct: 2463 EDALKSLEN-----QTYFKSFEENGKGSIINLETRLLQLESTVSAK--DLELTQCYKQIK 2515
Query: 279 QLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEK 338
+QEQ ET L+ + + +K+ + +K A +S+I+ E ++ + +
Sbjct: 2516 DMQEQ-----GQFETEMLQKKIVNLQKI-VEEKVAAALVSQIQL--EAVQEYAKFCQDNQ 2567
Query: 339 QESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKN 398
S E + ++++ N ++L S+ R + Q++ + L K +EI
Sbjct: 2568 TISSEPERTNIQNLNQLREDELGSDISALTLR--ISELESQVVEMHTSLILEKEQVEIAE 2625
Query: 399 EKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMD 440
+ + +++ KL++++KL++ N ++ Q+E E+ ++ D
Sbjct: 2626 KNVLEKEKKLLELQKLLEGN-------EKKQREKEKKRSPQD 2660
Score = 34.3 bits (77), Expect = 0.28
Identities = 49/243 (20%), Positives = 112/243 (46%), Gaps = 24/243 (9%)
Query: 199 KQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKT--ERENRLKE 256
++ K LS+EL E++ +++ + ++++ + T+ E + +KT R++ E
Sbjct: 1512 EEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISE---EMFSKDKTFIVRQSIHDE 1568
Query: 257 FYTREYEKLRDTYI--EEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYE 314
+ R + E+ E + +L Q+ H+ + + +H ++E ++ E
Sbjct: 1569 ISVSSMDASRQLMLNEEQLEDMRQELVRQYQE----HQQATELLRQAHMRQMERQREDQE 1624
Query: 315 ASLSEIKK-GHEIEKKSL---EDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAR 370
EIK+ ++ ++S E+L+SE++ L +++ LK + A EKL E + +
Sbjct: 1625 QLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQ 1684
Query: 371 EKANLKN----PQIMYLEQELESL-----KAVLEIKNEKLHQQDIKLMKMEKLVDNNTAL 421
+ +N + + E+EL+ +L + L + + +L+K+ V TA
Sbjct: 1685 TQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAA 1744
Query: 422 VDK 424
V++
Sbjct: 1745 VEE 1747
>gi|124249396 coiled-coil domain containing 30 [Homo sapiens]
Length = 783
Score = 69.3 bits (168), Expect = 8e-12
Identities = 92/365 (25%), Positives = 169/365 (46%), Gaps = 68/365 (18%)
Query: 161 NQSGFILQLKQLL-----ACGNTKFEALTVVIQHLLSEREEALKQHKTLSQE-------- 207
NQ G + QL Q L C + + E Q+L LKQH +L QE
Sbjct: 236 NQQGEVQQLHQNLHRLQILCNSAENELRYERGQNL------DLKQHNSLLQEENIKIKIE 289
Query: 208 LVNLRGELVTASTTCEKLEKARNELQTVY---EAFVQQHQAEKTERENRLKEFYTREYEK 264
L + + +L+ ++ C L Q E V +H + + +N L+E +E K
Sbjct: 290 LKHAQQKLLDSTKMCSSLTAEYKHCQQKIKELELEVLKH-TQSIKSQNNLQEKLVQEKSK 348
Query: 265 LRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIK-KG 323
+ D AE+ + LQ + ++ + T + SEK +L +K EA+ +E K K
Sbjct: 349 VAD-----AEEKILDLQRKLEHAHKVCLT-----DTCISEKQQLEEKIKEATQNEAKVKQ 398
Query: 324 HEIEKKSLEDLLSEKQESLEKQINDLKS-----------------ENDALNEKLKSEEQK 366
E++ LL + + L +Q+ L+ + +AL ++L++E++K
Sbjct: 399 QYQEEQQKRKLLYQNVDELHRQVRTLQDKENLLEMTCSQQQSRIQQQEALLKQLENEKRK 458
Query: 367 RRAREKANLK-NPQIMYLEQELESLKA-------VLEIK----NEKLHQQDIKLMKMEKL 414
K+N + + ++ L+QE E+L+ +L + NEK HQQ +KL K++
Sbjct: 459 YDEHVKSNQELSEKLSKLQQEKEALREEYLRLLKLLNVHVRNYNEKHHQQKVKLQKVKYR 518
Query: 415 VDNNTALVDK-LKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSME 473
+ N L DK + +F+ E L+ +++K AI Q++ + L L ++ K+ +++ +E
Sbjct: 519 LTNEVELRDKRINQFEDEIGILQHKIEKEKAIQDQITAQNDTL---LLEKRKLQEQV-IE 574
Query: 474 NEELL 478
E+L+
Sbjct: 575 QEQLI 579
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.339
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,395,837
Number of Sequences: 37866
Number of extensions: 906311
Number of successful extensions: 11175
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 313
Number of HSP's successfully gapped in prelim test: 1256
Number of HSP's that attempted gapping in prelim test: 5268
Number of HSP's gapped (non-prelim): 4058
length of query: 517
length of database: 18,247,518
effective HSP length: 107
effective length of query: 410
effective length of database: 14,195,856
effective search space: 5820300960
effective search space used: 5820300960
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.