Search of human proteins with 5031695

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5031695 H factor (complement)-like 3 [Homo sapiens]
         (270 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5031695 H factor (complement)-like 3 [Homo sapiens]                582   e-167
gi|239758115 PREDICTED: similar to complement factor H-related 1...   505   e-143
gi|118442839 complement factor H-related 1 [Homo sapiens]             471   e-133
gi|239758113 PREDICTED: similar to complement factor H-related 1...   471   e-133
gi|13540563 complement factor H-related 5 [Homo sapiens]              267   8e-72
gi|54792787 complement factor H-related 3 [Homo sapiens]              239   2e-63
gi|62739186 complement factor H isoform a precursor [Homo sapiens]    236   1e-62
gi|117320518 complement factor H-related 4 [Homo sapiens]             229   1e-60
gi|110611237 coagulation factor XIII B subunit precursor [Homo s...   157   1e-38
gi|62739188 complement factor H isoform b precursor [Homo sapiens]    128   6e-30
gi|4502503 complement component 4 binding protein, alpha chain p...    73   3e-13
gi|42544177 complement component (3d/Epstein Barr virus) recepto...    69   3e-12
gi|54792123 complement component (3d/Epstein Barr virus) recepto...    69   3e-12
gi|148886654 polydom [Homo sapiens]                                    67   2e-11
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi...    66   4e-11
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi...    66   4e-11
gi|168693643 decay accelerating factor for complement isoform 2 ...    60   2e-09
gi|10835143 decay accelerating factor for complement isoform 1 p...    60   2e-09
gi|153266841 apolipoprotein H precursor [Homo sapiens]                 60   2e-09
gi|148539593 sushi domain containing 4 isoform a [Homo sapiens]        57   2e-08
gi|62912468 complement component 4 binding protein, beta chain i...    55   5e-08
gi|62912466 complement component 4 binding protein, beta chain i...    55   5e-08
gi|62912464 complement component 4 binding protein, beta chain i...    55   5e-08
gi|62912462 complement component 4 binding protein, beta chain i...    55   5e-08
gi|4502505 complement component 4 binding protein, beta chain is...    55   5e-08
gi|148922949 complement component (3b/4b) receptor 1-like [Homo ...    55   5e-08
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]           54   1e-07
gi|38045915 pregnancy-associated plasma protein A preproprotein ...    52   5e-07
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]            51   9e-07
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap...    50   2e-06

>gi|5031695 H factor (complement)-like 3 [Homo sapiens]
          Length = 270

 Score =  582 bits (1501), Expect = e-167
 Identities = 270/270 (100%), Positives = 270/270 (100%)

Query: 1   MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
           MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
Sbjct: 1   MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60

Query: 61  SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
           SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
Sbjct: 61  SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120

Query: 121 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 180
           QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 180

Query: 181 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV 240
           LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV
Sbjct: 181 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV 240

Query: 241 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK 270
           CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK
Sbjct: 241 CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK 270


>gi|239758115 PREDICTED: similar to complement factor H-related 1
           isoform 2 [Homo sapiens]
          Length = 271

 Score =  505 bits (1300), Expect = e-143
 Identities = 234/271 (86%), Positives = 246/271 (90%), Gaps = 1/271 (0%)

Query: 1   MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
           MWLLVSVILISRISSVGGEA FCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
Sbjct: 1   MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60

Query: 61  SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
           SPSKSFWTRITC EEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
Sbjct: 61  SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120

Query: 121 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 180
           QNNENNISCVERGWSTPPKCRST S  KCGPPPPIDNGDITSF LSVYAP SSVEYQCQN
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQN 180

Query: 181 LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV 240
           LYQLEGN +ITCRNGQWSEPPKCL PCVIS+EIME YNI L+WT +QKLY RTG+  EFV
Sbjct: 181 LYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFV 240

Query: 241 CKSGYH-PTKSHSFRAMCQNGKLVYPSCEEK 270
           CK GY   ++SH+ R  C +GKL YP+C ++
Sbjct: 241 CKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 271


>gi|118442839 complement factor H-related 1 [Homo sapiens]
          Length = 330

 Score =  471 bits (1211), Expect = e-133
 Identities = 232/330 (70%), Positives = 245/330 (74%), Gaps = 60/330 (18%)

Query: 1   MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
           MWLLVSVILISRISSVGGEA FCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
Sbjct: 1   MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60

Query: 61  SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
           SPSKSFWTRITC EEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
Sbjct: 61  SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120

Query: 121 QNNENNISCVERGWSTPP------------------------------------KCRSTI 144
           QNNENNISCVERGWSTPP                                    +CRS  
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180

Query: 145 -----------------------SAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNL 181
                                  S  KCGPPPPIDNGDITSF LSVYAP SSVEYQCQNL
Sbjct: 181 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 240

Query: 182 YQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVC 241
           YQLEGN +ITCRNGQWSEPPKCL PCVIS+EIME YNI L+WT +QKLY RTG+  EFVC
Sbjct: 241 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC 300

Query: 242 KSGYH-PTKSHSFRAMCQNGKLVYPSCEEK 270
           K GY   ++SH+ R  C +GKL YP+C ++
Sbjct: 301 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330


>gi|239758113 PREDICTED: similar to complement factor H-related 1
           isoform 1 [Homo sapiens]
          Length = 330

 Score =  471 bits (1211), Expect = e-133
 Identities = 232/330 (70%), Positives = 245/330 (74%), Gaps = 60/330 (18%)

Query: 1   MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
           MWLLVSVILISRISSVGGEA FCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV
Sbjct: 1   MWLLVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60

Query: 61  SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
           SPSKSFWTRITC EEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL
Sbjct: 61  SPSKSFWTRITCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120

Query: 121 QNNENNISCVERGWSTPP------------------------------------KCRSTI 144
           QNNENNISCVERGWSTPP                                    +CRS  
Sbjct: 121 QNNENNISCVERGWSTPPKCRSTDTSCVNPPTVQNAHILSRQMSKYPSGERVRYECRSPY 180

Query: 145 -----------------------SAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNL 181
                                  S  KCGPPPPIDNGDITSF LSVYAP SSVEYQCQNL
Sbjct: 181 EMFGDEEVMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNL 240

Query: 182 YQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVC 241
           YQLEGN +ITCRNGQWSEPPKCL PCVIS+EIME YNI L+WT +QKLY RTG+  EFVC
Sbjct: 241 YQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYLRTGESAEFVC 300

Query: 242 KSGYH-PTKSHSFRAMCQNGKLVYPSCEEK 270
           K GY   ++SH+ R  C +GKL YP+C ++
Sbjct: 301 KRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 330


>gi|13540563 complement factor H-related 5 [Homo sapiens]
          Length = 569

 Score =  267 bits (682), Expect = 8e-72
 Identities = 131/198 (66%), Positives = 146/198 (73%), Gaps = 3/198 (1%)

Query: 1   MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV 60
           M LL SVILIS +S+VGGE   CDFPKI+HG LYDEE Y PFSQVPTGEVFYYSCEYNFV
Sbjct: 1   MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFV 60

Query: 61  SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
           SPSKSFWTRITC EEGWSPTPKCLR+C FPFV+NGHSESSG  HLEGDTVQIICNTGY L
Sbjct: 61  SPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSL 120

Query: 121 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 180
           QNNE NISCVERGWSTPP C  + +  +C  P    N D      S Y  G  +++ C+ 
Sbjct: 121 QNNEKNISCVERGWSTPPIC--SFTKGECHVPILEANVDAQPKKES-YKVGDVLKFSCRK 177

Query: 181 LYQLEGNNQITCRNGQWS 198
                G++ + C    WS
Sbjct: 178 NLIRVGSDSVQCYQFGWS 195



 Score =  185 bits (469), Expect = 4e-47
 Identities = 94/203 (46%), Positives = 124/203 (61%), Gaps = 9/203 (4%)

Query: 72  CAEEGWSPTPKCL--RLCFFP---FVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENN 126
           C    W+P   C   R  F P    + N  + ++   + +G+ V ++C   Y L   +  
Sbjct: 370 CINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKE- 428

Query: 127 ISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEG 186
           I C +  W + P+C    S   CGPPP I+NGD TSF LSVY PGS+V Y+CQ+ Y+L+G
Sbjct: 429 IVCKDGRWQSLPRCVE--STAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQG 486

Query: 187 NNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYH 246
           +  +TCRN QWSEPP+CLDPCV+S+E M K NI+LKW N  KLY++TGD VEF CK  + 
Sbjct: 487 SVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHK 546

Query: 247 P-TKSHSFRAMCQNGKLVYPSCE 268
               S  FRA+CQ GK  YP CE
Sbjct: 547 AMISSPPFRAICQEGKFEYPICE 569



 Score = 81.6 bits (200), Expect = 6e-16
 Identities = 65/225 (28%), Positives = 100/225 (44%), Gaps = 29/225 (12%)

Query: 36  EEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPT-PKC---LRLCFFP- 90
           +E YK       G+V  +SC  N +         + C + GWSP  P C   +R C  P 
Sbjct: 162 KESYK------VGDVLKFSCRKNLIRVGSD---SVQCYQFGWSPNFPTCKGQVRSCGPPP 212

Query: 91  FVENGH-SESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKC 149
            + NG   E   + +   + V+  CN  + + N    I CV+  W+T P C   +    C
Sbjct: 213 QLSNGEVKEIRKEEYGHNEVVEYDCNPNFII-NGPKKIQCVDGEWTTLPTCVEQVKT--C 269

Query: 150 GPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVI 209
           G  P ++ G +   +   Y  G SVE  C+N Y + GNN ITC NG W+E P C+    +
Sbjct: 270 GYIPELEYGYVQPSV-PPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQL 328

Query: 210 SQEIMEKYNIKL-------KWTNQQKLYSRTGDIVEF---VCKSG 244
            +  +   NIK        ++ +  ++  R  DI  +   VC +G
Sbjct: 329 KRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCING 373



 Score = 34.7 bits (78), Expect = 0.090
 Identities = 21/79 (26%), Positives = 30/79 (37%), Gaps = 7/79 (8%)

Query: 189 QITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPT 248
           +ITC    WS  PKCL  C           +K   +    L    GD V+ +C +GY   
Sbjct: 69  RITCTEEGWSPTPKCLRMCSFP-------FVKNGHSESSGLIHLEGDTVQIICNTGYSLQ 121

Query: 249 KSHSFRAMCQNGKLVYPSC 267
            +    +  + G    P C
Sbjct: 122 NNEKNISCVERGWSTPPIC 140



 Score = 32.3 bits (72), Expect = 0.45
 Identities = 21/62 (33%), Positives = 28/62 (45%), Gaps = 7/62 (11%)

Query: 26  PKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLR 85
           P IN+G   D   + P S  P G    Y C+ +F     S    +TC  + WS  P+CL 
Sbjct: 453 PSINNG---DTTSF-PLSVYPPGSTVTYRCQ-SFYKLQGS--VTVTCRNKQWSEPPRCLD 505

Query: 86  LC 87
            C
Sbjct: 506 PC 507


>gi|54792787 complement factor H-related 3 [Homo sapiens]
          Length = 330

 Score =  239 bits (610), Expect = 2e-63
 Identities = 125/332 (37%), Positives = 179/332 (53%), Gaps = 66/332 (19%)

Query: 1   MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCE---- 56
           M LL++VIL   +S   G+   CDFP I HG L+ E   +P+  V  G+ + Y C+    
Sbjct: 1   MLLLINVILTLWVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFE 60

Query: 57  ------YNFVSPSKSFW------------------------------------------- 67
                 ++++  +++ W                                           
Sbjct: 61  TPSGSYWDYIHCTQNGWSPAVPCLRKCYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGL 120

Query: 68  ----TRITCAEEGWSPTPKCLRLCFFPF----VENGHSESSGQTHLEGDTVQIICNTGYR 119
               T +TC E+GWSPTP+C+R+         +ENG    S   ++    +Q  C  GY 
Sbjct: 121 PKAQTTVTCTEKGWSPTPRCIRVRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYA 180

Query: 120 LQ--NNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQ 177
               N+  +I+C++ GWS  P C +  S+EKCGPPPPI NGD TSFLL VY P S VEYQ
Sbjct: 181 TADGNSSGSITCLQNGWSAQPICIN--SSEKCGPPPPISNGDTTSFLLKVYVPQSRVEYQ 238

Query: 178 CQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIV 237
           CQ  Y+L+G+N +TC NG+WSEPP+C+ PC+I++E M K NIKLK  + +K Y++TGD +
Sbjct: 239 CQPYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIKLKGRSDRKYYAKTGDTI 298

Query: 238 EFVCKSGYHP-TKSHSFRAMCQNGKLVYPSCE 268
           EF+CK GY+  T   SF+A+C+ G + YP CE
Sbjct: 299 EFMCKLGYNANTSILSFQAVCREGIVEYPRCE 330


>gi|62739186 complement factor H isoform a precursor [Homo sapiens]
          Length = 1231

 Score =  236 bits (603), Expect = 1e-62
 Identities = 119/227 (52%), Positives = 149/227 (65%), Gaps = 10/227 (4%)

Query: 48   GEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFF--PFVENGHSESSGQT-H 104
            GE   Y+C   +     S    +TC    W+  P C        P V+N +  S   + +
Sbjct: 1011 GEQVTYTCATYYKMDGAS---NVTCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKY 1067

Query: 105  LEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFL 164
              G+ V+  C + Y +  +E  + C+   W+ PP+C+   S  KCGPPPPIDNGDITSF 
Sbjct: 1068 PSGERVRYQCRSPYEMFGDEE-VMCLNGNWTEPPQCKD--STGKCGPPPPIDNGDITSFP 1124

Query: 165  LSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWT 224
            LSVYAP SSVEYQCQNLYQLEGN +ITCRNGQWSEPPKCL PCVIS+EIME YNI L+WT
Sbjct: 1125 LSVYAPASSVEYQCQNLYQLEGNKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWT 1184

Query: 225  NQQKLYSRTGDIVEFVCKSGYH-PTKSHSFRAMCQNGKLVYPSCEEK 270
             +QKLYSRTG+ VEFVCK GY   ++SH+ R  C +GKL YP+C ++
Sbjct: 1185 AKQKLYSRTGESVEFVCKRGYRLSSRSHTLRTTCWDGKLEYPTCAKR 1231



 Score =  154 bits (390), Expect = 6e-38
 Identities = 82/254 (32%), Positives = 129/254 (50%), Gaps = 17/254 (6%)

Query: 23  CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPK 82
           CD+P I HG LY E   +P+  V  G+ + Y C+ +F +PS S+W  I C ++GWSP   
Sbjct: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384

Query: 83  CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRS 142
           CLR C+FP++ENG++++ G+  ++G ++ + C+ GY L   +  ++C+E GWS  P+C  
Sbjct: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC-- 442

Query: 143 TISAEKCGPPP-PIDNGDITSFLLSVYAPGSSVEYQCQNLYQL---EGNNQITCRNGQWS 198
            I  + C      I+NG I+    + YA     +YQC+  Y     E +  ITC    WS
Sbjct: 443 -IRVKTCSKSSIDIENGFISESQYT-YALKEKAKYQCKLGYVTADGETSGSITCGKDGWS 500

Query: 199 EPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHP-TKSHSFRAMC 257
             P C+  C I   +  +      W        +  D +++ C  GY   T S +   +C
Sbjct: 501 AQPTCIKSCDIPVFMNARTKNDFTW-------FKLNDTLDYECHDGYESNTGSTTGSIVC 553

Query: 258 -QNGKLVYPSCEEK 270
             NG    P C E+
Sbjct: 554 GYNGWSDLPICYER 567



 Score = 80.5 bits (197), Expect = 1e-15
 Identities = 56/226 (24%), Positives = 92/226 (40%), Gaps = 14/226 (6%)

Query: 23  CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPK 82
           CD P     +  +      F+     +   Y C   + S + S    I C   GWS  P 
Sbjct: 509 CDIP-----VFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPI 563

Query: 83  CL-RLCFFPFVE-NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PK 139
           C  R C  P ++ +   +     +  G+ ++  C  G+ +    N++ C   G S   P 
Sbjct: 564 CYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVG-PNSVQCYHFGLSPDLPI 622

Query: 140 CRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSE 199
           C+  +  + CGPPP + NG++       Y     VEY C   + ++G N+I C +G+W+ 
Sbjct: 623 CKEQV--QSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTT 680

Query: 200 PPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
            P C+       +I E   ++  W          GD VEF C   +
Sbjct: 681 LPVCIVEESTCGDIPE---LEHGWAQLSSPPYYYGDSVEFNCSESF 723



 Score = 76.3 bits (186), Expect = 3e-14
 Identities = 63/243 (25%), Positives = 94/243 (38%), Gaps = 20/243 (8%)

Query: 26   PKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLR 85
            P+I HG +      +       G    Y+CE  F    ++     TC    WS  P+C  
Sbjct: 874  PQIEHGTINSSRSSQ--ESYAHGTKLSYTCEGGFRISEEN---ETTCYMGKWSSPPQCEG 928

Query: 86   L-CFFP-FVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRST 143
            L C  P  + +G       ++  G+ V   C  G+ + +      C+   WS PP C  T
Sbjct: 929  LPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGI-DGPAIAKCLGEKWSHPPSCIKT 987

Query: 144  ISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKC 203
                 C   P  +N         VY  G  V Y C   Y+++G + +TC N +W+  P C
Sbjct: 988  ----DCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNVTCINSRWTGRPTC 1043

Query: 204  LD-PCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKL 262
             D  CV    +   Y +    + Q   Y  +G+ V + C+S Y          MC NG  
Sbjct: 1044 RDTSCVNPPTVQNAYIV----SRQMSKYP-SGERVRYQCRSPYEMFGDE--EVMCLNGNW 1096

Query: 263  VYP 265
              P
Sbjct: 1097 TEP 1099



 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 53/226 (23%), Positives = 76/226 (33%), Gaps = 21/226 (9%)

Query: 49  EVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
           E F Y C   +    +       C E GW P P C  + C  P++ NG        H  G
Sbjct: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287

Query: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSV 167
           D +   C  G+      N   C   GW   P+C    + + C  P     G     +   
Sbjct: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC----TLKPCDYPDIKHGGLYHENMRRP 343

Query: 168 YAP---GSSVEYQCQNLYQLEGN---NQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKL 221
           Y P   G    Y C   ++       + I C    WS    CL  C     +   YN   
Sbjct: 344 YFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPY-LENGYN--- 399

Query: 222 KWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSC 267
              N  + + + G  ++  C  GY   K+ +     +NG    P C
Sbjct: 400 --QNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442



 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 60/252 (23%), Positives = 99/252 (39%), Gaps = 24/252 (9%)

Query: 24  DFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWT----RITCAEEGWSP 79
           D P++ HG       +   S  P    +YY     F + S+SF       ITC    W+ 
Sbjct: 693 DIPELEHG-------WAQLSSPP----YYYGDSVEF-NCSESFTMIGHRSITCIHGVWTQ 740

Query: 80  TPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNIS--CVERGWSTP 137
            P+C+ +      ++ +     +            N  YR +  E  I   C+   W   
Sbjct: 741 LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPE 800

Query: 138 PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQW 197
             C S    + C PPP I N    +  L+ Y  G  V   CQ  Y ++   +ITC++G+W
Sbjct: 801 VNC-SMAQIQLCPPPPQIPNSHNMTTTLN-YRDGEKVSVLCQENYLIQEGEEITCKDGRW 858

Query: 198 SEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMC 257
              P C++    SQ    ++       + Q+ Y+  G  + + C+ G+  ++ +     C
Sbjct: 859 QSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAH-GTKLSYTCEGGFRISEEN--ETTC 915

Query: 258 QNGKLVY-PSCE 268
             GK    P CE
Sbjct: 916 YMGKWSSPPQCE 927



 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 50/164 (30%), Positives = 76/164 (46%), Gaps = 19/164 (11%)

Query: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLS---VYA 169
           CN GY+L    N   C   GW+   P C       KC P    +NG I S  +     Y 
Sbjct: 114 CNEGYQLLGEINYRECDTDGWTNDIPIC----EVVKCLPVTAPENGKIVSSAMEPDREYH 169

Query: 170 PGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKCLDPCVISQEIMEKYNIKLKWTNQQ 227
            G +V + C + Y++EG+ ++ C  +G WS E PKC++    S +++    I       Q
Sbjct: 170 FGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPI------SQ 223

Query: 228 KLYSRTGDIVEFVCKSGYHPTKSHSFRAMC-QNGKLVYPSCEEK 270
           K+  +  +  ++ C  GY    S    A+C ++G    PSCEEK
Sbjct: 224 KIIYKENERFQYKCNMGYE--YSERGDAVCTESGWRPLPSCEEK 265



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 50/208 (24%), Positives = 83/208 (39%), Gaps = 22/208 (10%)

Query: 72  CAEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
           C  +GW+   P C  +   P    ENG   SS     + +  G  V+ +CN+GY+++ +E
Sbjct: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188

Query: 125 NNISCVERG-WSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLY 182
             + C + G WS   PKC        C  P  I+   I+  +  +Y      +Y+C   Y
Sbjct: 189 E-MHCSDDGFWSKEKPKCVEI----SCKSPDVINGSPISQKI--IYKENERFQYKCNMGY 241

Query: 183 QLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCK 242
           +        C    W   P C +    +  I       L+      +  RTGD + + C+
Sbjct: 242 EYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLR------IKHRTGDEITYQCR 295

Query: 243 SGYHPTKSHSFRAMCQNGKLVYPSCEEK 270
           +G++P    +       G +  P C  K
Sbjct: 296 NGFYPATRGNTAKCTSTGWIPAPRCTLK 323



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 42/148 (28%), Positives = 51/148 (34%), Gaps = 5/148 (3%)

Query: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGD 159
           S QT+ EG      C  GYR   N   + C +  W      R       CG P     G 
Sbjct: 38  SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKC-QKRPCGHPGDTPFGT 95

Query: 160 ITSFLLSVYAPGSSVEYQCQNLYQLEGN-NQITCRNGQW-SEPPKCLDPCVISQEIMEKY 217
            T    +V+  G    Y C   YQL G  N   C    W ++ P C     +     E  
Sbjct: 96  FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENG 155

Query: 218 NIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
            I        + Y   G  V FVC SGY
Sbjct: 156 KIVSSAMEPDREY-HFGQAVRFVCNSGY 182



 Score = 35.8 bits (81), Expect = 0.040
 Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 2/54 (3%)

Query: 146 AEKCGPPPPIDNGDIT--SFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQW 197
           AE C   PP  N +I   S+    Y  G+   Y+C+  Y+  GN  + CR G+W
Sbjct: 18  AEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71


>gi|117320518 complement factor H-related 4 [Homo sapiens]
          Length = 331

 Score =  229 bits (585), Expect = 1e-60
 Identities = 127/333 (38%), Positives = 172/333 (51%), Gaps = 67/333 (20%)

Query: 1   MWLLVSVILISRISSVGG-EAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYN- 58
           M LL++VIL   +S   G E   CDFP+I HG LY +   + +     G+ + Y C+ N 
Sbjct: 1   MLLLINVILTLWVSCANGQEVKPCDFPEIQHGGLYYKSLRRLYFPAAAGQSYSYYCDQNF 60

Query: 59  --------------------------------------FVSPSKSFWT------------ 68
                                                 F+S S S +             
Sbjct: 61  VTPSGSYWDYIHCTQDGWSPTVPCLRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPG 120

Query: 69  ----------RITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGY 118
                      ITC + GWS  P C++ C  P  EN  ++S+G      DT+   C  GY
Sbjct: 121 YATADGNSSGSITCLQNGWSAQPICIKFCDMPVFENSRAKSNGMRFKLHDTLDYECYDGY 180

Query: 119 RLQ--NNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEY 176
            +   N   +I C E GWS  P C +  S+EKCGPPPPI NGD TSFLL VY P S VEY
Sbjct: 181 EISYGNTTGSIVCGEDGWSHFPTCYN--SSEKCGPPPPISNGDTTSFLLKVYVPQSRVEY 238

Query: 177 QCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDI 236
           QCQ+ Y+L+G+N +TC NG+WSEPP+C+ PC+I++E M K NI+LK  +  K Y++TGD 
Sbjct: 239 QCQSYYELQGSNYVTCSNGEWSEPPRCIHPCIITEENMNKNNIQLKGKSDIKYYAKTGDT 298

Query: 237 VEFVCKSGYHP-TKSHSFRAMCQNGKLVYPSCE 268
           +EF+CK GY+  T   SF+A+C+ G + YP CE
Sbjct: 299 IEFMCKLGYNANTSVLSFQAVCREGIVEYPRCE 331


>gi|110611237 coagulation factor XIII B subunit precursor [Homo
           sapiens]
          Length = 661

 Score =  157 bits (396), Expect = 1e-38
 Identities = 82/232 (35%), Positives = 119/232 (51%), Gaps = 17/232 (7%)

Query: 48  GEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLR-----LCFFP-FVENGHSESSG 101
           GE+ +  CE NF     +    I C +  W+  PKC+       C  P F+ENG +    
Sbjct: 295 GEIVHIECELNFEIHGSA---EIRCEDGKWTEPPKCIEGQEKVACEEPPFIENGAANLHS 351

Query: 102 QTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDIT 161
           + +  GD V   C +GY L  + N I+C    W+ PP+C    + E C  PP + NG + 
Sbjct: 352 KIYYNGDKVTYACKSGYLLHGS-NEITCNRGKWTLPPECVE--NNENCKHPPVVMNGAVA 408

Query: 162 SFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKL 221
             +L+ YA GSSVEY+C   Y L G+    C  G+WS PP CL+PC ++ + M + NI++
Sbjct: 409 DGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEM 468

Query: 222 KWTNQQKLYSRTGDIVEFVCKSGYH---PTKSHSFRAMCQNGKLVYPSCEEK 270
           KW  + K+    GD+++FVCK GY     T        C  G++ YP C  K
Sbjct: 469 KWKYEGKVLH--GDLIDFVCKQGYDLSPLTPLSELSVQCNRGEVKYPLCTRK 518



 Score =  124 bits (312), Expect = 7e-29
 Identities = 79/236 (33%), Positives = 113/236 (47%), Gaps = 21/236 (8%)

Query: 47  TGEVFYYSC-EYNFVSPSKSFWTRITCAEEG-WSPTPKCLRLCFF--PFVENGHSESSGQ 102
           TG    Y C EY  +  SK     I+  E+G WS  P CL  C     ++   + E   +
Sbjct: 417 TGSSVEYRCNEYYLLRGSK-----ISRCEQGKWSSPPVCLEPCTVNVDYMNRNNIEMKWK 471

Query: 103 TH---LEGDTVQIICNTGYRLQN----NENNISCVERGWSTPPKCRSTISAEKCGPPPPI 155
                L GD +  +C  GY L      +E ++ C  RG    P C    S   C  PP I
Sbjct: 472 YEGKVLHGDLIDFVCKQGYDLSPLTPLSELSVQC-NRGEVKYPLCTRKESKGMCTSPPLI 530

Query: 156 DNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIME 215
            +G I S  +  Y  GSSVEY+C + + LEG+ +  C +G W+ PP CL+PC +S   ME
Sbjct: 531 KHGVIISSTVDTYENGSSVEYRCFDHHFLEGSREAYCLDGMWTTPPLCLEPCTLSFTEME 590

Query: 216 KYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSH----SFRAMCQNGKLVYPSC 267
           K N+ LKW    + +   G+ +EF+C+   +P + +      R  C  G+L YP C
Sbjct: 591 KNNLLLKWDFDNRPHILHGEYIEFICRGDTYPAELYITGSILRMQCDRGQLKYPRC 646



 Score =  101 bits (252), Expect = 6e-22
 Identities = 67/219 (30%), Positives = 97/219 (44%), Gaps = 16/219 (7%)

Query: 53  YSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTV 110
           Y C   + +        + C   GWS TPKC +L       +ENG+     QT+ EGD V
Sbjct: 178 YECATGYYTAGGKKTEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEEGDVV 237

Query: 111 QIICNTGYRLQNNENNISCVERGW-STPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYA 169
           Q  C+  Y L  ++  I C   GW    P C       +C PPP   N  I +   + Y 
Sbjct: 238 QFFCHENYYLSGSDL-IQCYNFGWYPESPVCEGR--RNRCPPPPLPINSKIQTHS-TTYR 293

Query: 170 PGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKL 229
            G  V  +C+  +++ G+ +I C +G+W+EPPKC++     QE +              L
Sbjct: 294 HGEIVHIECELNFEIHGSAEIRCEDGKWTEPPKCIE----GQEKVACEEPPFIENGAANL 349

Query: 230 YSR---TGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVYP 265
           +S+    GD V + CKSGY    S+     C  GK   P
Sbjct: 350 HSKIYYNGDKVTYACKSGYLLHGSNEI--TCNRGKWTLP 386



 Score = 85.1 bits (209), Expect = 6e-17
 Identities = 65/241 (26%), Positives = 100/241 (41%), Gaps = 35/241 (14%)

Query: 31  GILYDEEKYKPFSQVPTGEV--FYYS-----------------CEYNFVSPSKSFWTRIT 71
           G LY EEK   F  V  G +  +YY+                 C   + + S     + T
Sbjct: 16  GELYAEEKPCGFPHVENGRIAQYYYTFKSFYFPMSIDKKLSFFCLAGYTTESGRQEEQTT 75

Query: 72  CAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQ--NNENNISC 129
           C  EGWSP P+C + C  P + NG+       +   + ++  C +GY+     +E  + C
Sbjct: 76  CTTEGWSPEPRCFKKCTKPDLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQC 135

Query: 130 VERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEG--- 186
           +  GWS+ P CR     E C   P + NG+  S     +     V+Y+C   Y   G   
Sbjct: 136 LSDGWSSQPTCRK--EHETC-LAPELYNGNY-STTQKTFKVKDKVQYECATGYYTAGGKK 191

Query: 187 NNQITCRNGQWSEPPKCLDPCVISQEIMEK-YNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
             ++ C    WS  PKC      S  ++E  Y   +K T ++      GD+V+F C   Y
Sbjct: 192 TEEVECLTYGWSLTPKCTKLKCSSLRLIENGYFHPVKQTYEE------GDVVQFFCHENY 245

Query: 246 H 246
           +
Sbjct: 246 Y 246


>gi|62739188 complement factor H isoform b precursor [Homo sapiens]
          Length = 449

 Score =  128 bits (321), Expect = 6e-30
 Identities = 47/118 (39%), Positives = 77/118 (65%)

Query: 23  CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPK 82
           CD+P I HG LY E   +P+  V  G+ + Y C+ +F +PS S+W  I C ++GWSP   
Sbjct: 325 CDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVP 384

Query: 83  CLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKC 140
           CLR C+FP++ENG++++ G+  ++G ++ + C+ GY L   +  ++C+E GWS  P+C
Sbjct: 385 CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442



 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 53/226 (23%), Positives = 76/226 (33%), Gaps = 21/226 (9%)

Query: 49  EVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCL-RLCFFPFVENGHSESSGQTHLEG 107
           E F Y C   +    +       C E GW P P C  + C  P++ NG        H  G
Sbjct: 231 ERFQYKCNMGYEYSERG---DAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTG 287

Query: 108 DTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSV 167
           D +   C  G+      N   C   GW   P+C    + + C  P     G     +   
Sbjct: 288 DEITYQCRNGFYPATRGNTAKCTSTGWIPAPRC----TLKPCDYPDIKHGGLYHENMRRP 343

Query: 168 YAP---GSSVEYQCQNLYQLEGN---NQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKL 221
           Y P   G    Y C   ++       + I C    WS    CL  C     +   YN   
Sbjct: 344 YFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFPY-LENGYN--- 399

Query: 222 KWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSC 267
              N  + + + G  ++  C  GY   K+ +     +NG    P C
Sbjct: 400 --QNHGRKFVQ-GKSIDVACHPGYALPKAQTTVTCMENGWSPTPRC 442



 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 50/164 (30%), Positives = 76/164 (46%), Gaps = 19/164 (11%)

Query: 114 CNTGYRLQNNENNISCVERGWSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLS---VYA 169
           CN GY+L    N   C   GW+   P C       KC P    +NG I S  +     Y 
Sbjct: 114 CNEGYQLLGEINYRECDTDGWTNDIPIC----EVVKCLPVTAPENGKIVSSAMEPDREYH 169

Query: 170 PGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKCLDPCVISQEIMEKYNIKLKWTNQQ 227
            G +V + C + Y++EG+ ++ C  +G WS E PKC++    S +++    I       Q
Sbjct: 170 FGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVINGSPI------SQ 223

Query: 228 KLYSRTGDIVEFVCKSGYHPTKSHSFRAMC-QNGKLVYPSCEEK 270
           K+  +  +  ++ C  GY    S    A+C ++G    PSCEEK
Sbjct: 224 KIIYKENERFQYKCNMGYE--YSERGDAVCTESGWRPLPSCEEK 265



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 50/208 (24%), Positives = 83/208 (39%), Gaps = 22/208 (10%)

Query: 72  CAEEGWS-PTPKCLRLCFFPFV--ENGHSESSG----QTHLEGDTVQIICNTGYRLQNNE 124
           C  +GW+   P C  +   P    ENG   SS     + +  G  V+ +CN+GY+++ +E
Sbjct: 129 CDTDGWTNDIPICEVVKCLPVTAPENGKIVSSAMEPDREYHFGQAVRFVCNSGYKIEGDE 188

Query: 125 NNISCVERG-WSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLY 182
             + C + G WS   PKC        C  P  I+   I+  +  +Y      +Y+C   Y
Sbjct: 189 E-MHCSDDGFWSKEKPKCVEI----SCKSPDVINGSPISQKI--IYKENERFQYKCNMGY 241

Query: 183 QLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCK 242
           +        C    W   P C +    +  I       L+      +  RTGD + + C+
Sbjct: 242 EYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLR------IKHRTGDEITYQCR 295

Query: 243 SGYHPTKSHSFRAMCQNGKLVYPSCEEK 270
           +G++P    +       G +  P C  K
Sbjct: 296 NGFYPATRGNTAKCTSTGWIPAPRCTLK 323



 Score = 55.1 bits (131), Expect = 6e-08
 Identities = 48/196 (24%), Positives = 80/196 (40%), Gaps = 25/196 (12%)

Query: 19  EAMFCDFPKINHGILYDEEKYKPFS-QVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGW 77
           E   CD P I +G       Y P   +  TG+   Y C   F   ++    +  C   GW
Sbjct: 263 EEKSCDNPYIPNG------DYSPLRIKHRTGDEITYQCRNGFYPATRGNTAK--CTSTGW 314

Query: 78  SPTPKC-LRLCFFPFVENG--HSESSGQTHLE---GDTVQIICNTGYRLQNNE--NNISC 129
            P P+C L+ C +P +++G  + E+  + +     G      C+  +   +    ++I C
Sbjct: 315 IPAPRCTLKPCDYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHC 374

Query: 130 VERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQL-EGNN 188
            + GWS    C       KC  P  ++NG   +     +  G S++  C   Y L +   
Sbjct: 375 TQDGWSPAVPC-----LRKCYFPY-LENGYNQNHGRK-FVQGKSIDVACHPGYALPKAQT 427

Query: 189 QITCRNGQWSEPPKCL 204
            +TC    WS  P+C+
Sbjct: 428 TVTCMENGWSPTPRCI 443



 Score = 45.4 bits (106), Expect = 5e-05
 Identities = 23/66 (34%), Positives = 35/66 (53%), Gaps = 7/66 (10%)

Query: 23  CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPK 82
           C FP + +G  Y++   + F Q   G+    +C   +  P     T +TC E GWSPTP+
Sbjct: 389 CYFPYLENG--YNQNHGRKFVQ---GKSIDVACHPGYALPKAQ--TTVTCMENGWSPTPR 441

Query: 83  CLRLCF 88
           C+R+ F
Sbjct: 442 CIRVSF 447



 Score = 38.9 bits (89), Expect = 0.005
 Identities = 42/148 (28%), Positives = 51/148 (34%), Gaps = 5/148 (3%)

Query: 100 SGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGD 159
           S QT+ EG      C  GYR   N   + C +  W      R       CG P     G 
Sbjct: 38  SDQTYPEGTQAIYKCRPGYRSLGNVIMV-CRKGEWVALNPLRKC-QKRPCGHPGDTPFGT 95

Query: 160 ITSFLLSVYAPGSSVEYQCQNLYQLEGN-NQITCRNGQW-SEPPKCLDPCVISQEIMEKY 217
            T    +V+  G    Y C   YQL G  N   C    W ++ P C     +     E  
Sbjct: 96  FTLTGGNVFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENG 155

Query: 218 NIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
            I        + Y   G  V FVC SGY
Sbjct: 156 KIVSSAMEPDREY-HFGQAVRFVCNSGY 182



 Score = 35.8 bits (81), Expect = 0.040
 Identities = 19/54 (35%), Positives = 27/54 (50%), Gaps = 2/54 (3%)

Query: 146 AEKCGPPPPIDNGDIT--SFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQW 197
           AE C   PP  N +I   S+    Y  G+   Y+C+  Y+  GN  + CR G+W
Sbjct: 18  AEDCNELPPRRNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEW 71


>gi|4502503 complement component 4 binding protein, alpha chain
           precursor [Homo sapiens]
          Length = 597

 Score = 72.8 bits (177), Expect = 3e-13
 Identities = 56/192 (29%), Positives = 87/192 (45%), Gaps = 17/192 (8%)

Query: 17  GGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG 76
           G EA+ C  PK+N+G +    K +P +      V++Y  E +F     S ++ I   +  
Sbjct: 359 GCEALCCPEPKLNNGEITQHRKSRPANHC----VYFYGDEISFSCHETSRFSAICQGDGT 414

Query: 77  WSP-TPKCLRLCFF-PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
           WSP TP C  +C F P + +GH + S       + +   C+ GY L   +  +SC    W
Sbjct: 415 WSPRTPSCGDICNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILV-GQAKLSCSYSHW 473

Query: 135 STP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR 193
           S P P+C++          P + NG + S     Y    +V  QC + Y + G   ITC 
Sbjct: 474 SAPAPQCKALCR------KPELVNGRL-SVDKDQYVEPENVTIQCDSGYGVVGPQSITCS 526

Query: 194 NGQ--WSEPPKC 203
             +  + E PKC
Sbjct: 527 GNRTWYPEVPKC 538



 Score = 54.7 bits (130), Expect = 8e-08
 Identities = 56/261 (21%), Positives = 102/261 (39%), Gaps = 20/261 (7%)

Query: 22  FCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSC-EYNFVSPSKSFWTRITCAEEGWS-P 79
           FC + +  H       + +  + +  G    +SC E  F+  S +    +     GWS P
Sbjct: 107 FCIYKRCRHPGELRNGQVEIKTDLSFGSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHP 166

Query: 80  TPKC--LRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG---- 133
            P+C  ++    P + NG        +  G +V   C+  + L  + + ISC        
Sbjct: 167 LPQCEIVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHAS-ISCTVENETIG 225

Query: 134 -WSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC 192
            W   P     I+  K    P + +G++ S    +Y    ++ ++CQ  + L G++ I C
Sbjct: 226 VWRPSPPTCEKITCRK----PDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHC 281

Query: 193 -RNGQWSEPPKCLDP--CVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTK 249
             + +W+  P   +P  C+   +I            ++ +Y   G ++ + C  GY PT 
Sbjct: 282 DADSKWNPSPPACEPNSCINLPDIPHASWETYPRPTKEDVYV-VGTVLRYRCHPGYKPTT 340

Query: 250 SHSFRAMCQNGK--LVYPSCE 268
                 +CQ       Y  CE
Sbjct: 341 DEPTTVICQKNLRWTPYQGCE 361



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 38/146 (26%), Positives = 64/146 (43%), Gaps = 24/146 (16%)

Query: 23  CDFP-KINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWS-PT 80
           C+FP KI HG       Y  F      E   Y C+  ++   ++   +++C+   WS P 
Sbjct: 426 CNFPPKIAHGHYKQSSSYSFFK-----EEIIYECDKGYILVGQA---KLSCSYSHWSAPA 477

Query: 81  PKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISC----------V 130
           P+C  LC  P + NG        ++E + V I C++GY +   + +I+C           
Sbjct: 478 PQCKALCRKPELVNGRLSVDKDQYVEPENVTIQCDSGYGVVGPQ-SITCSGNRTWYPEVP 536

Query: 131 ERGWSTPPKCRSTISAEK---CGPPP 153
           +  W TP  C   ++ ++   C P P
Sbjct: 537 KCEWETPEGCEQVLTGKRLMQCLPNP 562



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 58/229 (25%), Positives = 82/229 (35%), Gaps = 31/229 (13%)

Query: 48  GEVFYYSCEYNFVSPSKSFWTRITCAEE-GWSPTPKCLRLCF-FPFVENG----HSESSG 101
           G V  Y C   +  P+    T + C +   W+P   C  LC   P + NG    H +S  
Sbjct: 325 GTVLRYRCHPGY-KPTTDEPTTVICQKNLRWTPYQGCEALCCPEPKLNNGEITQHRKSRP 383

Query: 102 QTH---LEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNG 158
             H     GD +   C+   R      +  C   G  +P   R+    + C  PP I +G
Sbjct: 384 ANHCVYFYGDEISFSCHETSRF-----SAICQGDGTWSP---RTPSCGDICNFPPKIAHG 435

Query: 159 DIT-SFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEP-PKCLDPCVISQEIMEK 216
               S   S +     + Y+C   Y L G  +++C    WS P P+C   C       E 
Sbjct: 436 HYKQSSSYSFFK--EEIIYECDKGYILVGQAKLSCSYSHWSAPAPQCKALC----RKPEL 489

Query: 217 YNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVYP 265
            N +L     Q +       V   C SGY      S    C   +  YP
Sbjct: 490 VNGRLSVDKDQYVEPEN---VTIQCDSGYGVVGPQSI--TCSGNRTWYP 533


>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
           isoform 2 [Homo sapiens]
          Length = 1033

 Score = 69.3 bits (168), Expect = 3e-12
 Identities = 67/240 (27%), Positives = 88/240 (36%), Gaps = 22/240 (9%)

Query: 45  VPTGEVFYYSCEYNFVSPSKSFWTRITC--AEEGWS-PTPKC-----LRLCFFPFVENGH 96
           +  G V  YSC   F    +     IT    +  W  P PKC        C  P V  G+
Sbjct: 41  IAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGY 100

Query: 97  SESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP--PKCRSTISAEKCGPPPP 154
                  +  GD+V   C T + +  N++        W     P C S    E C   P 
Sbjct: 101 KIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLE-CPALPM 159

Query: 155 IDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWSE-PPKCLDPCVISQE 212
           I NG  TS  +   APG SV Y C++ Y L G   I C  +G+WS  PP C +    S  
Sbjct: 160 IHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLG 219

Query: 213 IMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVY---PSCEE 269
                 +K      +    R G    F C  GY      S R +     + +   P CEE
Sbjct: 220 RFPNGKVK------EPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEE 273



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 61/211 (28%), Positives = 88/211 (41%), Gaps = 19/211 (9%)

Query: 48  GEVFYYSCEYNF-VSPSKSFWTRITCAEEG-WS-PTPKCLRL-----CFFPFVENGHS-E 98
           G    Y C+  F +   K    R      G WS P+P+CLR      C  P V++G+   
Sbjct: 741 GNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLN 800

Query: 99  SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP--PKCRSTISAEKCGPPPPID 156
            +   +   D V + CN G+ + N    I C       P  P C        C PPP   
Sbjct: 801 KTHSAYSHNDIVYVDCNPGF-IMNGSRVIRCHTDNTWVPGVPTCIKKAFIG-CPPPPKTP 858

Query: 157 NGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWSEP-PKCLDPCVISQEIM 214
           NG+ T   ++ ++PG S+ Y C   Y L G   + C   G WS+P P C +    S   M
Sbjct: 859 NGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADM 918

Query: 215 EKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
           +      K    +K+Y + G +V   C+ GY
Sbjct: 919 DGIQ---KGLEPRKMY-QYGAVVTLECEDGY 945



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 54/205 (26%), Positives = 84/205 (40%), Gaps = 30/205 (14%)

Query: 19  EAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCE------YNFVSPSKSFWTRITC 72
           E +FC  P     IL         + V  G +  Y+C+       NF+   +S    + C
Sbjct: 272 EEIFCPSPP---PILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGES---TLRC 325

Query: 73  AEEG-----WS-PTPKC-----LRLCFFPFVENGHSESSGQT-HLEGDTVQIICNTGYRL 120
             +      WS P P+C        C  P +  G   S  +  +   DTV   C  G+ L
Sbjct: 326 TVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTL 385

Query: 121 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 180
           + ++  I C  +G   P    + +  ++C  PP I NG      +  + PG+S++Y C  
Sbjct: 386 KGSKQ-IRCNAQGTWEPS---APVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNP 441

Query: 181 LYQLEGNNQITCRN-GQWSEP-PKC 203
            Y L G   I C + G W+ P P+C
Sbjct: 442 GYVLVGEESIQCTSEGVWTPPVPQC 466



 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 56/195 (28%), Positives = 78/195 (40%), Gaps = 32/195 (16%)

Query: 96  HSESSGQTHLEGDTVQII---CNTGYRL--------QNNENNISCVERGWSTPPKCRSTI 144
           H   S Q    G  V+++   C  GY+L        Q+ EN I      +   P C+   
Sbjct: 664 HVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGI-----WFKKIPLCKVI- 717

Query: 145 SAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-----NGQWSE 199
               C PPP I NG  T  +   +  G+ V Y+C   + L G  ++ CR     +G WS 
Sbjct: 718 ---HCHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSG 774

Query: 200 P-PKCL--DPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAM 256
           P P+CL   P         K+  KL  T+    YS   DIV   C  G+    S   R  
Sbjct: 775 PSPQCLRSPPVTRCPNPEVKHGYKLNKTH--SAYSH-NDIVYVDCNPGFIMNGSRVIRCH 831

Query: 257 CQNGKLV-YPSCEEK 270
             N  +   P+C +K
Sbjct: 832 TDNTWVPGVPTCIKK 846



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 47/188 (25%), Positives = 73/188 (38%), Gaps = 21/188 (11%)

Query: 23  CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITC-AEEGWSP-T 80
           C  P++ HG   +    K  S     ++ Y  C   F+         I C  +  W P  
Sbjct: 788 CPNPEVKHGYKLN----KTHSAYSHNDIVYVDCNPGFIMNGSRV---IRCHTDNTWVPGV 840

Query: 81  PKCLRLCFF-----PFVENG-HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
           P C++  F      P   NG H+  +      G ++   C+ GY L      +   E  W
Sbjct: 841 PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW 900

Query: 135 STP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR 193
           S P P C+       C  P  +D          +Y  G+ V  +C++ Y LEG+ Q  C+
Sbjct: 901 SQPAPHCKEV----NCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQ 956

Query: 194 NG-QWSEP 200
           +  QW+ P
Sbjct: 957 SDHQWNPP 964



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 38/133 (28%), Positives = 55/133 (41%), Gaps = 23/133 (17%)

Query: 149 CGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-----RNGQWSEP-PK 202
           CG PPPI NG I S+  +  A G+ + Y C   ++L G   + C      +G W +P PK
Sbjct: 23  CGSPPPILNGRI-SYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81

Query: 203 CLDPCVISQEIMEKYN------IKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAM 256
           C        E   KY+      +   +  +     R GD V F CK+ +    + S    
Sbjct: 82  C--------EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133

Query: 257 CQN--GKLVYPSC 267
             N  G    P+C
Sbjct: 134 ANNMWGPTRLPTC 146



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 70/314 (22%), Positives = 105/314 (33%), Gaps = 87/314 (27%)

Query: 20  AMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WS 78
           A+ C  P+I  G +   +K     +    +   ++C + F         +I C  +G W 
Sbjct: 348 AVQCPHPQILRGRMVSGQK----DRYTYNDTVIFACMFGFTLKGSK---QIRCNAQGTWE 400

Query: 79  PT-PKCLRLCFFP-FVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERGWS 135
           P+ P C + C  P  + NG  E       + G +++  CN GY L   E+ I C   G  
Sbjct: 401 PSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEES-IQCTSEGVW 459

Query: 136 TPP---------------------------------------------KCRSTI------ 144
           TPP                                             +C+ TI      
Sbjct: 460 TPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEI 519

Query: 145 ---SAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN------LYQLEGNNQITC--- 192
                  C PPP I NG  T   L  +  G++V Y C         + L G + I C   
Sbjct: 520 RLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSN 579

Query: 193 --RNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRT-----GDIVEFVCKSGY 245
               G WS P      C +S   ++  ++ +   N  K+  +       D V F C SG+
Sbjct: 580 DQERGTWSGPAPL---CKLSLLAVQCSHVHI--ANGYKISGKEAPYFYNDTVTFKCYSGF 634

Query: 246 HPTKSHSFRAMCQN 259
               S   R    N
Sbjct: 635 TLKGSSQIRCKADN 648



 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 54/187 (28%), Positives = 86/187 (45%), Gaps = 29/187 (15%)

Query: 90  PFVENG-HSESSGQTHLEGDTVQIICNTGYRLQNN-----ENNISCV----ERG-WSTP- 137
           P + NG H+ SS +    G TV   CN G           E+ I C     ERG WS P 
Sbjct: 531 PVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPA 590

Query: 138 PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQ 196
           P C+ ++ A +C     I NG   S   + Y    +V ++C + + L+G++QI C+ +  
Sbjct: 591 PLCKLSLLAVQCSHVH-IANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNT 649

Query: 197 WS-EPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTG-DIVEFVCKSGYHPTKSHSFR 254
           W  E P C           EK   +    + Q+L + +  ++V   C+ GY  T  H+++
Sbjct: 650 WDPEIPVC-----------EKETCQHVRQSLQELPAGSRVELVNTSCQDGYQLT-GHAYQ 697

Query: 255 AMCQNGK 261
            MCQ+ +
Sbjct: 698 -MCQDAE 703


>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
           isoform 1 [Homo sapiens]
          Length = 1092

 Score = 69.3 bits (168), Expect = 3e-12
 Identities = 67/240 (27%), Positives = 88/240 (36%), Gaps = 22/240 (9%)

Query: 45  VPTGEVFYYSCEYNFVSPSKSFWTRITC--AEEGWS-PTPKC-----LRLCFFPFVENGH 96
           +  G V  YSC   F    +     IT    +  W  P PKC        C  P V  G+
Sbjct: 41  IAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPKCEYFNKYSSCPEPIVPGGY 100

Query: 97  SESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP--PKCRSTISAEKCGPPPP 154
                  +  GD+V   C T + +  N++        W     P C S    E C   P 
Sbjct: 101 KIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQANNMWGPTRLPTCVSVFPLE-CPALPM 159

Query: 155 IDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWSE-PPKCLDPCVISQE 212
           I NG  TS  +   APG SV Y C++ Y L G   I C  +G+WS  PP C +    S  
Sbjct: 160 IHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKIINCLSSGKWSAVPPTCEEARCKSLG 219

Query: 213 IMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVY---PSCEE 269
                 +K      +    R G    F C  GY      S R +     + +   P CEE
Sbjct: 220 RFPNGKVK------EPPILRVGVTANFFCDEGYRLQGPPSSRCVIAGQGVAWTKMPVCEE 273



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 61/211 (28%), Positives = 88/211 (41%), Gaps = 19/211 (9%)

Query: 48   GEVFYYSCEYNF-VSPSKSFWTRITCAEEG-WS-PTPKCLRL-----CFFPFVENGHS-E 98
            G    Y C+  F +   K    R      G WS P+P+CLR      C  P V++G+   
Sbjct: 800  GNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPVTRCPNPEVKHGYKLN 859

Query: 99   SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP--PKCRSTISAEKCGPPPPID 156
             +   +   D V + CN G+ + N    I C       P  P C        C PPP   
Sbjct: 860  KTHSAYSHNDIVYVDCNPGF-IMNGSRVIRCHTDNTWVPGVPTCIKKAFIG-CPPPPKTP 917

Query: 157  NGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWSEP-PKCLDPCVISQEIM 214
            NG+ T   ++ ++PG S+ Y C   Y L G   + C   G WS+P P C +    S   M
Sbjct: 918  NGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKEVNCSSPADM 977

Query: 215  EKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
            +      K    +K+Y + G +V   C+ GY
Sbjct: 978  DGIQ---KGLEPRKMY-QYGAVVTLECEDGY 1004



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 68/246 (27%), Positives = 97/246 (39%), Gaps = 44/246 (17%)

Query: 47  TGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WSPT-PKCLRLCFFPFVENGHSESSGQTH 104
           +G    Y+C+  ++         I C   G WSP+ P+C   C        H   S Q  
Sbjct: 682 SGMTVDYTCDPGYLLVGNK---SIHCMPSGNWSPSAPRCEETC-------QHVRQSLQEL 731

Query: 105 LEGDTVQII---CNTGYRL--------QNNENNISCVERGWSTPPKCRSTISAEKCGPPP 153
             G  V+++   C  GY+L        Q+ EN I      +   P C+       C PPP
Sbjct: 732 PAGSRVELVNTSCQDGYQLTGHAYQMCQDAENGI-----WFKKIPLCKVI----HCHPPP 782

Query: 154 PIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-----NGQWSEP-PKCL--D 205
            I NG  T  +   +  G+ V Y+C   + L G  ++ CR     +G WS P P+CL   
Sbjct: 783 VIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSP 842

Query: 206 PCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLV-Y 264
           P         K+  KL  T+    YS   DIV   C  G+    S   R    N  +   
Sbjct: 843 PVTRCPNPEVKHGYKLNKTH--SAYSH-NDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGV 899

Query: 265 PSCEEK 270
           P+C +K
Sbjct: 900 PTCIKK 905



 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 59/234 (25%), Positives = 92/234 (39%), Gaps = 36/234 (15%)

Query: 46  PTGEVFYYSC--------EYNFVSPSKSFWTRITCAEEGWS-PTPKC-LRL----CFFPF 91
           P G    Y+C        E++ +  S    T        WS P P C L L    C    
Sbjct: 547 PYGTTVTYTCNPGPERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVH 606

Query: 92  VENGHSESSGQT-HLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTISAEKC 149
           + NG+  S  +  +   DTV   C +G+ L+ +       +  W    P C      + C
Sbjct: 607 IANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCE-----KGC 661

Query: 150 GPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKCLDPC 207
             PP + +G  T      +  G +V+Y C   Y L GN  I C  +G WS   P+C + C
Sbjct: 662 QSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEETC 721

Query: 208 VISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGK 261
              Q + +          Q+       ++V   C+ GY  T  H+++ MCQ+ +
Sbjct: 722 ---QHVRQSL--------QELPAGSRVELVNTSCQDGYQLT-GHAYQ-MCQDAE 762



 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 54/205 (26%), Positives = 84/205 (40%), Gaps = 30/205 (14%)

Query: 19  EAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCE------YNFVSPSKSFWTRITC 72
           E +FC  P     IL         + V  G +  Y+C+       NF+   +S    + C
Sbjct: 272 EEIFCPSPP---PILNGRHIGNSLANVSYGSIVTYTCDPDPEEGVNFILIGES---TLRC 325

Query: 73  AEEG-----WS-PTPKC-----LRLCFFPFVENGHSESSGQT-HLEGDTVQIICNTGYRL 120
             +      WS P P+C        C  P +  G   S  +  +   DTV   C  G+ L
Sbjct: 326 TVDSQKTGTWSGPAPRCELSTSAVQCPHPQILRGRMVSGQKDRYTYNDTVIFACMFGFTL 385

Query: 121 QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 180
           + ++  I C  +G   P    + +  ++C  PP I NG      +  + PG+S++Y C  
Sbjct: 386 KGSKQ-IRCNAQGTWEPS---APVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNP 441

Query: 181 LYQLEGNNQITCRN-GQWSEP-PKC 203
            Y L G   I C + G W+ P P+C
Sbjct: 442 GYVLVGEESIQCTSEGVWTPPVPQC 466



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 47/188 (25%), Positives = 73/188 (38%), Gaps = 21/188 (11%)

Query: 23   CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITC-AEEGWSP-T 80
            C  P++ HG   +    K  S     ++ Y  C   F+         I C  +  W P  
Sbjct: 847  CPNPEVKHGYKLN----KTHSAYSHNDIVYVDCNPGFIMNGSRV---IRCHTDNTWVPGV 899

Query: 81   PKCLRLCFF-----PFVENG-HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
            P C++  F      P   NG H+  +      G ++   C+ GY L      +   E  W
Sbjct: 900  PTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTW 959

Query: 135  STP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR 193
            S P P C+       C  P  +D          +Y  G+ V  +C++ Y LEG+ Q  C+
Sbjct: 960  SQPAPHCKEV----NCSSPADMDGIQKGLEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQ 1015

Query: 194  NG-QWSEP 200
            +  QW+ P
Sbjct: 1016 SDHQWNPP 1023



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 38/133 (28%), Positives = 55/133 (41%), Gaps = 23/133 (17%)

Query: 149 CGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-----RNGQWSEP-PK 202
           CG PPPI NG I S+  +  A G+ + Y C   ++L G   + C      +G W +P PK
Sbjct: 23  CGSPPPILNGRI-SYYSTPIAVGTVIRYSCSGTFRLIGEKSLLCITKDKVDGTWDKPAPK 81

Query: 203 CLDPCVISQEIMEKYN------IKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAM 256
           C        E   KY+      +   +  +     R GD V F CK+ +    + S    
Sbjct: 82  C--------EYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQ 133

Query: 257 CQN--GKLVYPSC 267
             N  G    P+C
Sbjct: 134 ANNMWGPTRLPTC 146



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 70/314 (22%), Positives = 105/314 (33%), Gaps = 87/314 (27%)

Query: 20  AMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WS 78
           A+ C  P+I  G +   +K     +    +   ++C + F         +I C  +G W 
Sbjct: 348 AVQCPHPQILRGRMVSGQK----DRYTYNDTVIFACMFGFTLKGSK---QIRCNAQGTWE 400

Query: 79  PT-PKCLRLCFFP-FVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERGWS 135
           P+ P C + C  P  + NG  E       + G +++  CN GY L   E+ I C   G  
Sbjct: 401 PSAPVCEKECQAPPNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEES-IQCTSEGVW 459

Query: 136 TPP---------------------------------------------KCRSTI------ 144
           TPP                                             +C+ TI      
Sbjct: 460 TPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSCGEGYKLSGSVYQECQGTIPWFMEI 519

Query: 145 ---SAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN------LYQLEGNNQITC--- 192
                  C PPP I NG  T   L  +  G++V Y C         + L G + I C   
Sbjct: 520 RLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGPERGVEFSLIGESTIRCTSN 579

Query: 193 --RNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRT-----GDIVEFVCKSGY 245
               G WS P      C +S   ++  ++ +   N  K+  +       D V F C SG+
Sbjct: 580 DQERGTWSGPAPL---CKLSLLAVQCSHVHI--ANGYKISGKEAPYFYNDTVTFKCYSGF 634

Query: 246 HPTKSHSFRAMCQN 259
               S   R    N
Sbjct: 635 TLKGSSQIRCKADN 648


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 63/221 (28%), Positives = 95/221 (42%), Gaps = 37/221 (16%)

Query: 39   YKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WS-PTPKCLRLCFF--PFVEN 94
            Y   S    G +  YSC   F    +    + TC   G WS P P C  +     P VEN
Sbjct: 2156 YASGSNYSFGAMVAYSCNKGFYIKGEK---KSTCEATGQWSSPIPTCHPVSCGEPPKVEN 2212

Query: 95   GHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW--STPPKCRSTISAEKCGPP 152
            G  E +     E + V+  CN GY+   +   +    R W   +P  C        CG P
Sbjct: 2213 GFLEHTTGRIFESE-VRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVPL----DCGKP 2267

Query: 153  PPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWSE-------PPKCL 204
            PPI NG +      V   GS V++ C   Y+L G++  TC ++G+W++       P KC 
Sbjct: 2268 PPIQNGFMKGENFEV---GSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPAKCP 2324

Query: 205  DPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
            +P ++  +++ K           +L +  G +V F CK G+
Sbjct: 2325 EPPLLENQLVLK-----------ELTTEVG-VVTFSCKEGH 2353



 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 53/189 (28%), Positives = 80/189 (42%), Gaps = 26/189 (13%)

Query: 96   HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTISAEKCGPPPP 154
            H  ++ +    G  V + C+ G++L  N       +  W+ P P C        CG PPP
Sbjct: 1640 HLRTASEDLKPGSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERI----SCGVPPP 1695

Query: 155  IDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKCL--DPCVIS 210
            ++NG  ++     +  GS+V YQC N Y L G++++ C  NG W+   P CL  D C + 
Sbjct: 1696 LENGFHSA---DDFYAGSTVTYQCNNGYYLLGDSRMFCTDNGSWNGVSPSCLDVDECAVG 1752

Query: 211  QEIMEKYNIKLKWTNQQKLY------SRTGD----IVEFVCKSGYHPTKSHSFRAMCQNG 260
             +  E  +      N    Y        TGD         CK+  +P   HS   +   G
Sbjct: 1753 SDCSEHASC----LNVDGSYICSCVPPYTGDGKNCAEPIKCKAPGNPENGHSSGEIYTVG 1808

Query: 261  KLVYPSCEE 269
              V  SC+E
Sbjct: 1809 AEVTFSCQE 1817



 Score = 62.4 bits (150), Expect = 4e-10
 Identities = 62/215 (28%), Positives = 87/215 (40%), Gaps = 38/215 (17%)

Query: 47   TGEVFYYSCEYNFVSPSKSFW----TRITCAEEG-WSPT-PKCLRL-CFFPFV-ENGHSE 98
            +GE++    E  F S  + +     T+ITC E G W+   P C  + C  P + ENG  E
Sbjct: 1801 SGEIYTVGAEVTF-SCQEGYQLMGVTKITCLESGEWNHLIPYCKAVSCGKPAIPENGCIE 1859

Query: 99   SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWS-TPPKCRSTISAEKCGPPPPIDN 157
                T   G  V   CN GY L  ++ +       WS +PP C       KC  P  I+N
Sbjct: 1860 ELAFTF--GSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPV----KCSSPENINN 1913

Query: 158  GDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWSEPPK------CLDPCVIS 210
            G    ++LS     S+  Y C   Y L+G + I C  +G W   P       C +P  I 
Sbjct: 1914 G---KYILSGLTYLSTASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVFCGEPPAIK 1970

Query: 211  QEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
              ++   N   + T            V + CK GY
Sbjct: 1971 DAVITGNNFTFRNT------------VTYTCKEGY 1993



 Score = 61.2 bits (147), Expect = 9e-10
 Identities = 52/168 (30%), Positives = 68/168 (40%), Gaps = 19/168 (11%)

Query: 47   TGEVFYYSCE--YNFVSPSKSFWTRITCAEEG-WS-PTPKCL-RLCFFPFVENGHSESSG 101
            TG    YSC   Y+   PS++      C E G WS P P C    C  PFV   ++  S 
Sbjct: 3317 TGPNVVYSCNRGYSLEGPSEAH-----CTENGTWSHPVPLCKPNPCPVPFVIPENALLSE 3371

Query: 102  QTHLEGDTVQIICNTGYRLQNNENNISCVERGWS-TPPKCRSTISAEKCGPPPPIDNGDI 160
            +       V I C  G+ LQ +       +  W+ T  KC        CGPP  ++N   
Sbjct: 3372 KEFYVDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKI----SCGPPAHVENAIA 3427

Query: 161  TSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWSEPPKCLDPC 207
                   Y  G  + Y C + Y LEG  +  C  NG W+ PP C   C
Sbjct: 3428 RGVH---YQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVC 3472



 Score = 58.2 bits (139), Expect = 8e-09
 Identities = 41/117 (35%), Positives = 55/117 (47%), Gaps = 13/117 (11%)

Query: 93   ENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG-WS-TPPKCRSTISAEKCG 150
            ENGHS  SG+ +  G  V   C  GY+L      I+C+E G W+   P C+    A  CG
Sbjct: 1796 ENGHS--SGEIYTVGAEVTFSCQEGYQLM-GVTKITCLESGEWNHLIPYCK----AVSCG 1848

Query: 151  PPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWSEPPKCLDP 206
             P   +NG I       +  GS V Y+C   Y L G+ + +C  N  WS  P   +P
Sbjct: 1849 KPAIPENGCIEEL---AFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEP 1902



 Score = 55.1 bits (131), Expect = 6e-08
 Identities = 58/205 (28%), Positives = 86/205 (41%), Gaps = 27/205 (13%)

Query: 73   AEEGWSPTPKCLR--LCFFPF-VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISC 129
            A   WS +P       C  P  + NG    SG T+L   T    C+TGY LQ   + I C
Sbjct: 1889 ANSSWSHSPPVCEPVKCSSPENINNGKYILSGLTYLS--TASYSCDTGYSLQG-PSIIEC 1945

Query: 130  VERG-WS-TPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGN 187
               G W   PP C        CG PP I +  IT    + +   ++V Y C+  Y L G 
Sbjct: 1946 TASGIWDRAPPACHLVF----CGEPPAIKDAVITG---NNFTFRNTVTYTCKEGYTLAGL 1998

Query: 188  NQITC-RNGQWS-EPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
            + I C  +G+WS    +CL        I++         + +  +   GDI  + C  GY
Sbjct: 1999 DTIECLADGKWSRSDQQCLAVSCDEPPIVDH-------ASPETAHRLFGDIAFYYCSDGY 2051

Query: 246  HPTKSHSFRAMCQ-NGKLVYPSCEE 269
              + + + + +C   GK V P  ++
Sbjct: 2052 --SLADNSQLLCNAQGKWVPPEGQD 2074



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 63/241 (26%), Positives = 94/241 (39%), Gaps = 44/241 (18%)

Query: 45   VPTGEVFYYSCE--------YNFVSPSKSFWTRITCAEEG-WSPTPKCLRLCFFPFVEN- 94
            V TGE   Y  E        Y   + + +F    TC ++G W P          P  EN 
Sbjct: 3132 VATGEAHTYESEVKLRCLEGYTMDTDTDTF----TCQKDGRWFPERISCSPKKCPLPENI 3187

Query: 95   GHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPP 154
             H    G        V + C  GY  +    ++  ++  W  PP    + S   CG P  
Sbjct: 3188 THILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWE-PPFSDESCSPVSCGKPES 3246

Query: 155  IDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS------EPPKCLDPC 207
             ++G +     S Y   S++ YQC+  Y+LEGN +  C+ N QWS      +  +C  P 
Sbjct: 3247 PEHGFVVG---SKYTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRCETP- 3302

Query: 208  VISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYH---PTKSHSFRAMCQNGKLVY 264
                  +E  N K    N+      TG  V + C  GY    P+++H      +NG   +
Sbjct: 3303 ------LEFLNGKADIENR-----TTGPNVVYSCNRGYSLEGPSEAH----CTENGTWSH 3347

Query: 265  P 265
            P
Sbjct: 3348 P 3348



 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 46/159 (28%), Positives = 69/159 (43%), Gaps = 20/159 (12%)

Query: 53   YSCEYNFVSPSKSFWTRITCAEEG-W---SPTPKCLRLCFFPFVENGHSESSGQTHLEGD 108
            Y+C+  F        T   C E G W    PT K +       + NG    +   +  G 
Sbjct: 2464 YTCKPGFELVGN---TTTLCGENGHWLGGKPTCKAIECLKPKEILNGKFSYTDLHY--GQ 2518

Query: 109  TVQIICNTGYRLQNNENNISCVERG-WSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLS 166
            TV   CN G+RL+   + ++C+E G W    P C    +A  C  P PI+NG +     +
Sbjct: 2519 TVTYSCNRGFRLEG-PSALTCLETGDWDVDAPSC----NAIHCDSPQPIENGFVEG---A 2570

Query: 167  VYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEP-PKCL 204
             Y+ G+ + Y C   +Q+ G+   TC    WS   P C+
Sbjct: 2571 DYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPTCM 2609



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 48/190 (25%), Positives = 77/190 (40%), Gaps = 26/190 (13%)

Query: 70   ITCAEEG-WSPTPK-CLRL-CFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENN 126
            I C  +G WS + + CL + C  P + + H+       L GD     C+ GY L +N   
Sbjct: 2001 IECLADGKWSRSDQQCLAVSCDEPPIVD-HASPETAHRLFGDIAFYYCSDGYSLADNSQL 2059

Query: 127  ISCVERGWSTP-----PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNL 181
            +   +  W  P     P+C     A  C  PP +    + S   + +A GS V ++C   
Sbjct: 2060 LCNAQGKWVPPEGQDMPRC----IAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEG 2115

Query: 182  YQLEGNNQITC-RNGQWSEPPKCLD----PCVISQEIMEKYNIKLKWTNQQKLYSRTGDI 236
            + L  + +I C R GQW+  P  +      C     IM  Y     ++         G +
Sbjct: 2116 FVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYS--------FGAM 2167

Query: 237  VEFVCKSGYH 246
            V + C  G++
Sbjct: 2168 VAYSCNKGFY 2177



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 50/184 (27%), Positives = 83/184 (45%), Gaps = 25/184 (13%)

Query: 70   ITCAEEG-WSPT-PKCLRL-CFFPFV-ENGHSESSGQTHLEGDTVQIICNTGYRLQNNEN 125
            + C E+G W+ + P C+ + C  P   ENG    + +T + G  VQ  C  G+ L  ++ 
Sbjct: 2697 LICQEDGTWNGSAPSCISIECDLPTAPENGFLRFT-ETSM-GSAVQYSCKPGHILAGSDL 2754

Query: 126  NISCVERGWS-TPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQL 184
             +    R WS   P+C     A  C  P P+ NG I     S Y   S++ Y+C   Y L
Sbjct: 2755 RLCLENRKWSGASPRCE----AISCKKPNPVMNGSIKG---SNYTYLSTLYYECDPGYVL 2807

Query: 185  EGNNQITCRNGQ-WSE-PPKCLDPCVISQEIMEKYNIK-LKWTNQQKLYSRTGDIVEFVC 241
             G  + TC++ + W E  P C+     S  +     ++  ++T Q++        +E+ C
Sbjct: 2808 NGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQVRGDEYTFQKE--------IEYTC 2859

Query: 242  KSGY 245
              G+
Sbjct: 2860 NEGF 2863



 Score = 48.9 bits (115), Expect = 5e-06
 Identities = 52/171 (30%), Positives = 71/171 (41%), Gaps = 21/171 (12%)

Query: 41   PFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WS-PTPKCLRL-CFFPF-VENGH 96
            P S +  G    YSC   F     S      C  +G WS P P+C+ + C  P  + NG 
Sbjct: 2394 PSSALHFGSTVKYSCVGGFFLRGNS---TTLCQPDGTWSSPLPECVPVECPQPEEIPNGI 2450

Query: 97   SESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG-W-STPPKCRSTISAEKCGPPPP 154
             +  G  +L   T    C  G+ L  N   + C E G W    P C+    A +C  P  
Sbjct: 2451 IDVQGLAYLS--TALYTCKPGFELVGNTTTL-CGENGHWLGGKPTCK----AIECLKPKE 2503

Query: 155  IDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWS-EPPKC 203
            I NG    F  +    G +V Y C   ++LEG + +TC   G W  + P C
Sbjct: 2504 ILNG---KFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSC 2551



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 46/182 (25%), Positives = 79/182 (43%), Gaps = 20/182 (10%)

Query: 69   RITCAEEG-W-SPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENN 126
            ++TC  +G W +  P C  +   P  +  H   +G + + G  +Q  C  GY+L  N + 
Sbjct: 2928 KLTCQSDGNWDAEIPLCKPVNCGPPEDLAHGFPNGFSFIHGGHIQYQCFPGYKLHGNSSR 2987

Query: 127  ISCVERGWS-TPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLE 185
                   WS + P C       +C   P I+ G +     + +  G +   QC   ++L 
Sbjct: 2988 RCLSNGSWSGSSPSCLPC----RCS-TPVIEYGTVNG---TDFDCGKAARIQCFKGFKLL 3039

Query: 186  GNNQITCR-NGQWSEP-PKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKS 243
            G ++ITC  +GQWS   P C      S  ++   N  +  T+  K      +++ + C+S
Sbjct: 3040 GLSEITCEADGQWSSGFPHCEHTSCGSLPMIP--NAFISETSSWK-----ENVITYSCRS 3092

Query: 244  GY 245
            GY
Sbjct: 3093 GY 3094



 Score = 46.2 bits (108), Expect = 3e-05
 Identities = 42/158 (26%), Positives = 67/158 (42%), Gaps = 17/158 (10%)

Query: 52   YYSCEYNFVSPSKSFWTRITCAEE-GWSPT-PKCLRL-CFFPFVENGHSESSGQTHLEGD 108
            YY C+  +V        R TC ++  W    P C+ + C  P V + + +  G  +    
Sbjct: 2798 YYECDPGYVLNGTE---RRTCQDDKNWDEDEPICIPVDCSSPPV-SANGQVRGDEYTFQK 2853

Query: 109  TVQIICNTGYRLQNNENNISCVERGWS-TPPKCRSTISAEKCGPPPPIDNGDITSFLLSV 167
             ++  CN G+ L+   + +      WS   P C       +C  PP + NG +T  L   
Sbjct: 2854 EIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPV----RCATPPQLANG-VTEGL--D 2906

Query: 168  YAPGSSVEYQCQNLYQLEGNNQITCR-NGQW-SEPPKC 203
            Y     V + C   Y L G  ++TC+ +G W +E P C
Sbjct: 2907 YGFMKEVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLC 2944



 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 67/279 (24%), Positives = 99/279 (35%), Gaps = 70/279 (25%)

Query: 42   FSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WS-PTPKCLRL-CFFPF-VENGHS 97
            ++ +  G+   YSC   F     S    +TC E G W    P C  + C  P  +ENG  
Sbjct: 2511 YTDLHYGQTVTYSCNRGFRLEGPS---ALTCLETGDWDVDAPSCNAIHCDSPQPIENGFV 2567

Query: 98   ESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTISAEKCGPPPPID 156
            E +  ++  G  +   C  G+++  +    +C E GWS+  P C        CG PP ID
Sbjct: 2568 EGADYSY--GAIIIYSCFPGFQVAGHAMQ-TCEESGWSSSIPTCMPI----DCGLPPHID 2620

Query: 157  NGDITSFL-------------------------------------------LSVYAPGSS 173
             GD T                                               S +  G+ 
Sbjct: 2621 FGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYGTM 2680

Query: 174  VEYQCQNLYQLEGNNQITCR-NGQWS-EPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYS 231
            V Y C   Y+L GN  + C+ +G W+   P C+   +         N  L++T      +
Sbjct: 2681 VSYTCNPGYELLGNPVLICQEDGTWNGSAPSCIS--IECDLPTAPENGFLRFTE-----T 2733

Query: 232  RTGDIVEFVCKSGYHPTKSHSFRAMCQNGKL--VYPSCE 268
              G  V++ CK G H       R   +N K     P CE
Sbjct: 2734 SMGSAVQYSCKPG-HILAGSDLRLCLENRKWSGASPRCE 2771



 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 44/171 (25%), Positives = 64/171 (37%), Gaps = 50/171 (29%)

Query: 72   CAEEG-WS-PTPKCLRLCFF--PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNI 127
            C  +G W+ P P C R+     P +ENG    S      G TV   CN GY L   ++ +
Sbjct: 1672 CLNQGQWTQPLPHCERISCGVPPPLENGFH--SADDFYAGSTVTYQCNNGYYLLG-DSRM 1728

Query: 128  SCVERG-WS-TPPKC-------------------------------------RSTISAEK 148
             C + G W+   P C                                     ++     K
Sbjct: 1729 FCTDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTGDGKNCAEPIK 1788

Query: 149  CGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWS 198
            C  P   +NG  +     +Y  G+ V + CQ  YQL G  +ITC  +G+W+
Sbjct: 1789 CKAPGNPENGHSSG---EIYTVGAEVTFSCQEGYQLMGVTKITCLESGEWN 1836



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 42/151 (27%), Positives = 65/151 (43%), Gaps = 26/151 (17%)

Query: 68   TRITCAEEG-WSPT-PKCLRLCF--FPFVENGH-SESSGQTHLEGDTVQIICNTGYRLQN 122
            + ITC  +G WS   P C        P + N   SE+S       + +   C +GY +Q 
Sbjct: 3042 SEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKE---NVITYSCRSGYVIQG 3098

Query: 123  NENNISCVERG-WSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 180
            + +++ C E+G WS P P C        CG PP + N   T      +   S V+ +C  
Sbjct: 3099 S-SDLICTEKGVWSQPYPVCEPL----SCGSPPSVANAVATG---EAHTYESEVKLRCLE 3150

Query: 181  LYQLE-GNNQITC-RNGQW------SEPPKC 203
             Y ++   +  TC ++G+W        P KC
Sbjct: 3151 GYTMDTDTDTFTCQKDGRWFPERISCSPKKC 3181



 Score = 32.7 bits (73), Expect = 0.34
 Identities = 19/70 (27%), Positives = 39/70 (55%), Gaps = 4/70 (5%)

Query: 178 CQNLYQLEGNNQITCR-NGQWSEP-PKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGD 235
           C   Y+LEG++++TC+ N QW  P P+C++    + ++ +  ++ +   N  K  ++ G 
Sbjct: 466 CDEGYRLEGSDKLTCQGNSQWDGPEPRCVERHCSTFQMPK--DVIISPHNCGKQPAKFGT 523

Query: 236 IVEFVCKSGY 245
           I    C+ G+
Sbjct: 524 ICYVSCRQGF 533



 Score = 30.4 bits (67), Expect = 1.7
 Identities = 28/101 (27%), Positives = 40/101 (39%), Gaps = 17/101 (16%)

Query: 70  ITCAEEG-WSPTPKCLRLCFFPFV---ENGHSESSGQTHLEGDTVQIICNTGYRLQNNEN 125
           I C   G WS +    R+   P +   ++GH   S +  L   T  + C+ GYRL+ ++ 
Sbjct: 418 ILCLPNGLWSGSESYCRVRTCPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDK 477

Query: 126 ------------NISCVERGWSTPPKCRST-ISAEKCGPPP 153
                          CVER  ST    +   IS   CG  P
Sbjct: 478 LTCQGNSQWDGPEPRCVERHCSTFQMPKDVIISPHNCGKQP 518



 Score = 28.5 bits (62), Expect = 6.5
 Identities = 15/49 (30%), Positives = 22/49 (44%), Gaps = 4/49 (8%)

Query: 48   GEVFYYSCEYNFVSPSKSFWTRITCAEEG-WSPTPKCLRLCFFPFVENG 95
            G++  YSC   ++      + R  C E G W+  P C  +C FP    G
Sbjct: 3435 GDMITYSCYSGYMLEG---FLRSVCLENGTWTSPPICRAVCRFPCQNGG 3480


>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
          Length = 2489

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 63/229 (27%), Positives = 95/229 (41%), Gaps = 37/229 (16%)

Query: 48   GEVFYYSCEYNFVSPSKSFWTRI--TCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHL 105
            G++F  SC  N V      W+ +   C  +   P P+       PF  NG    +  T  
Sbjct: 1882 GKMFSISCLENLV------WSSVEDNCRRKSCGPPPE-------PF--NGMVHINTDTQF 1926

Query: 106  EGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLL 165
             G TV   CN G+RL  + +    V     T  K         C PPP I NGD  S   
Sbjct: 1927 -GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNR 1985

Query: 166  SVYAPGSSVEYQC------QNLYQLEGNNQITCRN-----GQWSE-PPKCLDPCVISQEI 213
            + +  G+ V YQC      + L++L G   I C +     G WS  PP+C+     +   
Sbjct: 1986 TSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPE 2045

Query: 214  MEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQ-NGK 261
            +E     ++    +  ++ T +I+ F C+ G+    SH+    CQ NG+
Sbjct: 2046 VEN---AIRVPGNRSFFTLT-EIIRFRCQPGFVMVGSHT--VQCQTNGR 2088



 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 61/225 (27%), Positives = 95/225 (42%), Gaps = 37/225 (16%)

Query: 43  SQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQ 102
           S  P G    Y C   +     S    ITC +     +PK   +C     +      +G 
Sbjct: 511 SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 564

Query: 103 THL-----EGDTVQIICNTGYRLQNNENNISCVERG----WST-PPKCRSTISAEKCGPP 152
            H+      G  +   C TG+RL  + ++  C+  G    WST PP C+       CG P
Sbjct: 565 VHVITDIQVGSRINYSCTTGHRLIGH-SSAECILSGNAAHWSTKPPICQRI----PCGLP 619

Query: 153 PPIDNGDITSFLLSVYAPGSSVEYQC------QNLYQLEGNNQITCRN-----GQWSEP- 200
           P I NGD  S     +  GS V Y+C      + +++L G   I C +     G WS P 
Sbjct: 620 PTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 679

Query: 201 PKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
           P+C+ P   +   +E     +  ++ + L+S   ++VEF C+ G+
Sbjct: 680 PQCIIPNKCTPPNVEN---GILVSDNRSLFS-LNEVVEFRCQPGF 720



 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 61/225 (27%), Positives = 95/225 (42%), Gaps = 37/225 (16%)

Query: 43   SQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQ 102
            S  P G    Y C   +     S    ITC +     +PK   +C     +      +G 
Sbjct: 961  SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 1014

Query: 103  THL-----EGDTVQIICNTGYRLQNNENNISCVERG----WST-PPKCRSTISAEKCGPP 152
             H+      G  +   C TG+RL  + ++  C+  G    WST PP C+       CG P
Sbjct: 1015 VHVITDIQVGSRINYSCTTGHRLIGH-SSAECILSGNAAHWSTKPPICQRI----PCGLP 1069

Query: 153  PPIDNGDITSFLLSVYAPGSSVEYQC------QNLYQLEGNNQITCRN-----GQWSEP- 200
            P I NGD  S     +  GS V Y+C      + +++L G   I C +     G WS P 
Sbjct: 1070 PTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 1129

Query: 201  PKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
            P+C+ P   +   +E     +  ++ + L+S   ++VEF C+ G+
Sbjct: 1130 PQCIIPNKCTPPNVEN---GILVSDNRSLFS-LNEVVEFRCQPGF 1170



 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 61/225 (27%), Positives = 95/225 (42%), Gaps = 37/225 (16%)

Query: 43   SQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQ 102
            S  P G    Y C   +     S    ITC +     +PK   +C     +      +G 
Sbjct: 1411 SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 1464

Query: 103  THL-----EGDTVQIICNTGYRLQNNENNISCVERG----WST-PPKCRSTISAEKCGPP 152
             H+      G  +   C TG+RL  + ++  C+  G    WST PP C+       CG P
Sbjct: 1465 VHVITDIQVGSRINYSCTTGHRLIGH-SSAECILSGNTAHWSTKPPICQRI----PCGLP 1519

Query: 153  PPIDNGDITSFLLSVYAPGSSVEYQC------QNLYQLEGNNQITCRN-----GQWSEP- 200
            P I NGD  S     +  GS V Y+C      + +++L G   I C +     G WS P 
Sbjct: 1520 PTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPA 1579

Query: 201  PKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
            P+C+ P   +   +E     +  ++ + L+S   ++VEF C+ G+
Sbjct: 1580 PQCIIPNKCTPPNVEN---GILVSDNRSLFS-LNEVVEFRCQPGF 1620



 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 41/135 (30%), Positives = 58/135 (42%), Gaps = 14/135 (10%)

Query: 77   WS-PTPKCL--RLCFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVER 132
            WS P P+C+    C  P VENG   S  ++     + V+  C  G+ +      + C   
Sbjct: 1575 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF-VMKGPRRVKCQAL 1633

Query: 133  GWSTP--PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQI 190
                P  P C     +  C PPP I +G+ T      ++PG  V Y C+  Y L G   +
Sbjct: 1634 NKWEPELPSC-----SRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASL 1688

Query: 191  TCR-NGQWS-EPPKC 203
             C   G WS E P+C
Sbjct: 1689 HCTPQGDWSPEAPRC 1703



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 55/194 (28%), Positives = 80/194 (41%), Gaps = 31/194 (15%)

Query: 32  ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WSPT-PKC-LRLC- 87
           +L+ E   +       G+  +YSCE  +     +    + C  +G WSP  P C ++ C 
Sbjct: 303 VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA---SMRCTPQGDWSPAAPTCEVKSCD 359

Query: 88  -FFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----W-STPPKCR 141
            F   + NG         L G  V  +C+ G++L+ +  +  CV  G    W S+ P C 
Sbjct: 360 DFMGQLLNGRVLFPVNLQL-GAKVDFVCDEGFQLKGSSASY-CVLAGMESLWNSSVPVCE 417

Query: 142 STISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQ------NLYQLEGNNQITCR-- 193
                  C  PP I NG  T   L V+  G +V Y C         + L G + I C   
Sbjct: 418 QIF----CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 473

Query: 194 ---NGQWSEP-PKC 203
              NG WS P P+C
Sbjct: 474 PQGNGVWSSPAPRC 487



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 55/194 (28%), Positives = 80/194 (41%), Gaps = 31/194 (15%)

Query: 32  ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WSPT-PKC-LRLC- 87
           +L+ E   +       G+  +YSCE  +     +    + C  +G WSP  P C ++ C 
Sbjct: 753 VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA---SMRCTPQGDWSPAAPTCEVKSCD 809

Query: 88  -FFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----W-STPPKCR 141
            F   + NG         L G  V  +C+ G++L+ +  +  CV  G    W S+ P C 
Sbjct: 810 DFMGQLLNGRVLFPVNLQL-GAKVDFVCDEGFQLKGSSASY-CVLAGMESLWNSSVPVCE 867

Query: 142 STISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQ------NLYQLEGNNQITCR-- 193
                  C  PP I NG  T   L V+  G +V Y C         + L G + I C   
Sbjct: 868 QIF----CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 923

Query: 194 ---NGQWSEP-PKC 203
              NG WS P P+C
Sbjct: 924 PQGNGVWSSPAPRC 937



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 55/194 (28%), Positives = 80/194 (41%), Gaps = 31/194 (15%)

Query: 32   ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WSPT-PKC-LRLC- 87
            +L+ E   +       G+  +YSCE  +     +    + C  +G WSP  P C ++ C 
Sbjct: 1203 VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA---SMRCTPQGDWSPAAPTCEVKSCD 1259

Query: 88   -FFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----W-STPPKCR 141
             F   + NG         L G  V  +C+ G++L+ +  +  CV  G    W S+ P C 
Sbjct: 1260 DFMGQLLNGRVLFPVNLQL-GAKVDFVCDEGFQLKGSSASY-CVLAGMESLWNSSVPVCE 1317

Query: 142  STISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQ------NLYQLEGNNQITCR-- 193
                   C  PP I NG  T   L V+  G +V Y C         + L G + I C   
Sbjct: 1318 QIF----CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSD 1373

Query: 194  ---NGQWSEP-PKC 203
               NG WS P P+C
Sbjct: 1374 PQGNGVWSSPAPRC 1387



 Score = 52.0 bits (123), Expect = 5e-07
 Identities = 49/194 (25%), Positives = 75/194 (38%), Gaps = 26/194 (13%)

Query: 26   PKINHGILYDEEKYKPFSQVPTGEVFYYSCE--------YNFVSPSKSFWTRITCAEEGW 77
            P I++G  Y   +    +    G V  Y C         +  V     + T        W
Sbjct: 1973 PTISNGDFYSNNR----TSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVW 2028

Query: 78   S-PTPKCLRL--CFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERG 133
            S P P+C+    C  P VEN       ++     + ++  C  G+ +  + + + C   G
Sbjct: 2029 SSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGS-HTVQCQTNG 2087

Query: 134  WSTP--PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQIT 191
               P  P C     +  C PPP I +G+ T      ++PG  V Y C+  Y L G   + 
Sbjct: 2088 RWGPKLPHC-----SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH 2142

Query: 192  CR-NGQWS-EPPKC 203
            C   G WS E P+C
Sbjct: 2143 CTPQGDWSPEAPRC 2156



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 43/155 (27%), Positives = 70/155 (45%), Gaps = 24/155 (15%)

Query: 107 GDTVQIICNTGYRLQNNENNISCVERG----WSTPPKCRSTISAEKCGPPPPIDNGDITS 162
           G  ++  C  GYRL  + ++ +C+  G    W         I    CG PP I NGD  S
Sbjct: 124 GSQIKYSCTKGYRLIGS-SSATCIISGDTVIWDNETPICDRIP---CGLPPTITNGDFIS 179

Query: 163 FLLSVYAPGSSVEYQC------QNLYQLEGNNQITCRN-----GQWSEP-PKCLDPCVIS 210
                +  GS V Y+C      + +++L G   I C +     G WS P P+C+ P   +
Sbjct: 180 TNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCT 239

Query: 211 QEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
              +E     +  ++ + L+S   ++VEF C+ G+
Sbjct: 240 PPNVEN---GILVSDNRSLFS-LNEVVEFRCQPGF 270



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 53/203 (26%), Positives = 81/203 (39%), Gaps = 25/203 (12%)

Query: 19   EAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCE--------YNFVSPSKSFWTRI 70
            E +FC  P     IL       PF  +P G+   Y+C+        +N +  S    T  
Sbjct: 2220 EQIFCPNPP---AILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSD 2276

Query: 71   TCAEEGWS-PTPKC-----LRLCFFPFVENGHSESSGQT-HLEGDTVQIICNTGYRLQNN 123
                  WS P P+C           P ++NGH      + +L G T+  IC+ GY L   
Sbjct: 2277 PQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVG- 2335

Query: 124  ENNISCVERG-WSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLY 182
            +  I C ++G WS        ++   C  P  ++       +  VY  G  V  +C++ Y
Sbjct: 2336 KGFIFCTDQGIWSQLDHYCKEVN---CSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGY 2392

Query: 183  QLEGNNQITCRNGQWSEPP--KC 203
             LEG+    C+     +PP  KC
Sbjct: 2393 TLEGSPWSQCQADDRWDPPLAKC 2415



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 46/179 (25%), Positives = 72/179 (40%), Gaps = 23/179 (12%)

Query: 77  WS-PTPKCL--RLCFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVER 132
           WS P P+C+    C  P VENG   S  ++     + V+  C  G+ +      + C   
Sbjct: 225 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF-VMKGPRRVKCQAL 283

Query: 133 GWSTP--PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQI 190
               P  P C     +  C PPP + + + T      ++PG  V Y C+  Y L G   +
Sbjct: 284 NKWEPELPSC-----SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM 338

Query: 191 TCR-NGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYS---RTGDIVEFVCKSGY 245
            C   G WS       P   + E+    +   +  N + L+    + G  V+FVC  G+
Sbjct: 339 RCTPQGDWS-------PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 390



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 46/179 (25%), Positives = 72/179 (40%), Gaps = 23/179 (12%)

Query: 77  WS-PTPKCL--RLCFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVER 132
           WS P P+C+    C  P VENG   S  ++     + V+  C  G+ +      + C   
Sbjct: 675 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF-VMKGPRRVKCQAL 733

Query: 133 GWSTP--PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQI 190
               P  P C     +  C PPP + + + T      ++PG  V Y C+  Y L G   +
Sbjct: 734 NKWEPELPSC-----SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM 788

Query: 191 TCR-NGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYS---RTGDIVEFVCKSGY 245
            C   G WS       P   + E+    +   +  N + L+    + G  V+FVC  G+
Sbjct: 789 RCTPQGDWS-------PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 840



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 46/179 (25%), Positives = 72/179 (40%), Gaps = 23/179 (12%)

Query: 77   WS-PTPKCL--RLCFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVER 132
            WS P P+C+    C  P VENG   S  ++     + V+  C  G+ +      + C   
Sbjct: 1125 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF-VMKGPRRVKCQAL 1183

Query: 133  GWSTP--PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQI 190
                P  P C     +  C PPP + + + T      ++PG  V Y C+  Y L G   +
Sbjct: 1184 NKWEPELPSC-----SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM 1238

Query: 191  TCR-NGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYS---RTGDIVEFVCKSGY 245
             C   G WS       P   + E+    +   +  N + L+    + G  V+FVC  G+
Sbjct: 1239 RCTPQGDWS-------PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 1290



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 37/114 (32%), Positives = 51/114 (44%), Gaps = 6/114 (5%)

Query: 134  WSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC 192
            WS+P P+C  ++ A  C  PP I NG      +S+Y PG ++ Y C   Y L G   I C
Sbjct: 2283 WSSPAPRCELSVPAA-CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFC 2341

Query: 193  RN-GQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
             + G WS+          S  +    N   K    +K+Y   GD V   C+ GY
Sbjct: 2342 TDQGIWSQLDHYCKEVNCSFPLF--MNGISKELEMKKVY-HYGDYVTLKCEDGY 2392


>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
          Length = 2039

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 63/229 (27%), Positives = 95/229 (41%), Gaps = 37/229 (16%)

Query: 48   GEVFYYSCEYNFVSPSKSFWTRI--TCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHL 105
            G++F  SC  N V      W+ +   C  +   P P+       PF  NG    +  T  
Sbjct: 1432 GKMFSISCLENLV------WSSVEDNCRRKSCGPPPE-------PF--NGMVHINTDTQF 1476

Query: 106  EGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLL 165
             G TV   CN G+RL  + +    V     T  K         C PPP I NGD  S   
Sbjct: 1477 -GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCEPPPTISNGDFYSNNR 1535

Query: 166  SVYAPGSSVEYQC------QNLYQLEGNNQITCRN-----GQWSE-PPKCLDPCVISQEI 213
            + +  G+ V YQC      + L++L G   I C +     G WS  PP+C+     +   
Sbjct: 1536 TSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVWSSPPPRCISTNKCTAPE 1595

Query: 214  MEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQ-NGK 261
            +E     ++    +  ++ T +I+ F C+ G+    SH+    CQ NG+
Sbjct: 1596 VEN---AIRVPGNRSFFTLT-EIIRFRCQPGFVMVGSHT--VQCQTNGR 1638



 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 61/225 (27%), Positives = 95/225 (42%), Gaps = 37/225 (16%)

Query: 43  SQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQ 102
           S  P G    Y C   +     S    ITC +     +PK   +C     +      +G 
Sbjct: 511 SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 564

Query: 103 THL-----EGDTVQIICNTGYRLQNNENNISCVERG----WST-PPKCRSTISAEKCGPP 152
            H+      G  +   C TG+RL  + ++  C+  G    WST PP C+       CG P
Sbjct: 565 VHVITDIQVGSRINYSCTTGHRLIGH-SSAECILSGNAAHWSTKPPICQRI----PCGLP 619

Query: 153 PPIDNGDITSFLLSVYAPGSSVEYQC------QNLYQLEGNNQITCRN-----GQWSEP- 200
           P I NGD  S     +  GS V Y+C      + +++L G   I C +     G WS P 
Sbjct: 620 PTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPA 679

Query: 201 PKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
           P+C+ P   +   +E     +  ++ + L+S   ++VEF C+ G+
Sbjct: 680 PQCIIPNKCTPPNVEN---GILVSDNRSLFS-LNEVVEFRCQPGF 720



 Score = 58.9 bits (141), Expect = 4e-09
 Identities = 61/225 (27%), Positives = 95/225 (42%), Gaps = 37/225 (16%)

Query: 43   SQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQ 102
            S  P G    Y C   +     S    ITC +     +PK   +C     +      +G 
Sbjct: 961  SDFPIGTSLKYECRPEYYGRPFS----ITCLDNLVWSSPK--DVCKRKSCKTPPDPVNGM 1014

Query: 103  THL-----EGDTVQIICNTGYRLQNNENNISCVERG----WST-PPKCRSTISAEKCGPP 152
             H+      G  +   C TG+RL  + ++  C+  G    WST PP C+       CG P
Sbjct: 1015 VHVITDIQVGSRINYSCTTGHRLIGH-SSAECILSGNTAHWSTKPPICQRI----PCGLP 1069

Query: 153  PPIDNGDITSFLLSVYAPGSSVEYQC------QNLYQLEGNNQITCRN-----GQWSEP- 200
            P I NGD  S     +  GS V Y+C      + +++L G   I C +     G WS P 
Sbjct: 1070 PTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIWSGPA 1129

Query: 201  PKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
            P+C+ P   +   +E     +  ++ + L+S   ++VEF C+ G+
Sbjct: 1130 PQCIIPNKCTPPNVEN---GILVSDNRSLFS-LNEVVEFRCQPGF 1170



 Score = 53.1 bits (126), Expect = 2e-07
 Identities = 41/135 (30%), Positives = 58/135 (42%), Gaps = 14/135 (10%)

Query: 77   WS-PTPKCL--RLCFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVER 132
            WS P P+C+    C  P VENG   S  ++     + V+  C  G+ +      + C   
Sbjct: 1125 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF-VMKGPRRVKCQAL 1183

Query: 133  GWSTP--PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQI 190
                P  P C     +  C PPP I +G+ T      ++PG  V Y C+  Y L G   +
Sbjct: 1184 NKWEPELPSC-----SRVCQPPPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASL 1238

Query: 191  TCR-NGQWS-EPPKC 203
             C   G WS E P+C
Sbjct: 1239 HCTPQGDWSPEAPRC 1253



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 55/194 (28%), Positives = 80/194 (41%), Gaps = 31/194 (15%)

Query: 32  ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WSPT-PKC-LRLC- 87
           +L+ E   +       G+  +YSCE  +     +    + C  +G WSP  P C ++ C 
Sbjct: 303 VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA---SMRCTPQGDWSPAAPTCEVKSCD 359

Query: 88  -FFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----W-STPPKCR 141
            F   + NG         L G  V  +C+ G++L+ +  +  CV  G    W S+ P C 
Sbjct: 360 DFMGQLLNGRVLFPVNLQL-GAKVDFVCDEGFQLKGSSASY-CVLAGMESLWNSSVPVCE 417

Query: 142 STISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQ------NLYQLEGNNQITCR-- 193
                  C  PP I NG  T   L V+  G +V Y C         + L G + I C   
Sbjct: 418 QIF----CPSPPVIPNGRHTGKPLEVFPFGKTVNYTCDPHPDRGTSFDLIGESTIRCTSD 473

Query: 194 ---NGQWSEP-PKC 203
              NG WS P P+C
Sbjct: 474 PQGNGVWSSPAPRC 487



 Score = 52.8 bits (125), Expect = 3e-07
 Identities = 55/194 (28%), Positives = 80/194 (41%), Gaps = 31/194 (15%)

Query: 32  ILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WSPT-PKC-LRLC- 87
           +L+ E   +       G+  +YSCE  +     +    + C  +G WSP  P C ++ C 
Sbjct: 753 VLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAA---SMRCTPQGDWSPAAPTCEVKSCD 809

Query: 88  -FFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----W-STPPKCR 141
            F   + NG         L G  V  +C+ G++L+ +  +  CV  G    W S+ P C 
Sbjct: 810 DFMGQLLNGRVLFPVNLQL-GAKVDFVCDEGFQLKGSSASY-CVLAGMESLWNSSVPVCE 867

Query: 142 STISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQ------NLYQLEGNNQITCR-- 193
                  C  PP I NG  T   L V+  G +V Y C         + L G + I C   
Sbjct: 868 QIF----CPSPPVIPNGRHTGKPLEVFPFGKAVNYTCDPHPDRGTSFDLIGESTIRCTSD 923

Query: 194 ---NGQWSEP-PKC 203
              NG WS P P+C
Sbjct: 924 PQGNGVWSSPAPRC 937



 Score = 52.0 bits (123), Expect = 5e-07
 Identities = 49/194 (25%), Positives = 75/194 (38%), Gaps = 26/194 (13%)

Query: 26   PKINHGILYDEEKYKPFSQVPTGEVFYYSCE--------YNFVSPSKSFWTRITCAEEGW 77
            P I++G  Y   +    +    G V  Y C         +  V     + T        W
Sbjct: 1523 PTISNGDFYSNNR----TSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSKDDQVGVW 1578

Query: 78   S-PTPKCLRL--CFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERG 133
            S P P+C+    C  P VEN       ++     + ++  C  G+ +  + + + C   G
Sbjct: 1579 SSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGS-HTVQCQTNG 1637

Query: 134  WSTP--PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQIT 191
               P  P C     +  C PPP I +G+ T      ++PG  V Y C+  Y L G   + 
Sbjct: 1638 RWGPKLPHC-----SRVCQPPPEILHGEHTLSHQDNFSPGQEVFYSCEPSYDLRGAASLH 1692

Query: 192  CR-NGQWS-EPPKC 203
            C   G WS E P+C
Sbjct: 1693 CTPQGDWSPEAPRC 1706



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 43/155 (27%), Positives = 70/155 (45%), Gaps = 24/155 (15%)

Query: 107 GDTVQIICNTGYRLQNNENNISCVERG----WSTPPKCRSTISAEKCGPPPPIDNGDITS 162
           G  ++  C  GYRL  + ++ +C+  G    W         I    CG PP I NGD  S
Sbjct: 124 GSQIKYSCTKGYRLIGS-SSATCIISGDTVIWDNETPICDRIP---CGLPPTITNGDFIS 179

Query: 163 FLLSVYAPGSSVEYQC------QNLYQLEGNNQITCRN-----GQWSEP-PKCLDPCVIS 210
                +  GS V Y+C      + +++L G   I C +     G WS P P+C+ P   +
Sbjct: 180 TNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCT 239

Query: 211 QEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
              +E     +  ++ + L+S   ++VEF C+ G+
Sbjct: 240 PPNVEN---GILVSDNRSLFS-LNEVVEFRCQPGF 270



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 53/203 (26%), Positives = 81/203 (39%), Gaps = 25/203 (12%)

Query: 19   EAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCE--------YNFVSPSKSFWTRI 70
            E +FC  P     IL       PF  +P G+   Y+C+        +N +  S    T  
Sbjct: 1770 EQIFCPNPP---AILNGRHTGTPFGDIPYGKEISYACDTHPDRGMTFNLIGESSIRCTSD 1826

Query: 71   TCAEEGWS-PTPKC-----LRLCFFPFVENGHSESSGQT-HLEGDTVQIICNTGYRLQNN 123
                  WS P P+C           P ++NGH      + +L G T+  IC+ GY L   
Sbjct: 1827 PQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVG- 1885

Query: 124  ENNISCVERG-WSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLY 182
            +  I C ++G WS        ++   C  P  ++       +  VY  G  V  +C++ Y
Sbjct: 1886 KGFIFCTDQGIWSQLDHYCKEVN---CSFPLFMNGISKELEMKKVYHYGDYVTLKCEDGY 1942

Query: 183  QLEGNNQITCRNGQWSEPP--KC 203
             LEG+    C+     +PP  KC
Sbjct: 1943 TLEGSPWSQCQADDRWDPPLAKC 1965



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 46/179 (25%), Positives = 72/179 (40%), Gaps = 23/179 (12%)

Query: 77  WS-PTPKCL--RLCFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVER 132
           WS P P+C+    C  P VENG   S  ++     + V+  C  G+ +      + C   
Sbjct: 225 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF-VMKGPRRVKCQAL 283

Query: 133 GWSTP--PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQI 190
               P  P C     +  C PPP + + + T      ++PG  V Y C+  Y L G   +
Sbjct: 284 NKWEPELPSC-----SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM 338

Query: 191 TCR-NGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYS---RTGDIVEFVCKSGY 245
            C   G WS       P   + E+    +   +  N + L+    + G  V+FVC  G+
Sbjct: 339 RCTPQGDWS-------PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 390



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 46/179 (25%), Positives = 72/179 (40%), Gaps = 23/179 (12%)

Query: 77  WS-PTPKCL--RLCFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVER 132
           WS P P+C+    C  P VENG   S  ++     + V+  C  G+ +      + C   
Sbjct: 675 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGF-VMKGPRRVKCQAL 733

Query: 133 GWSTP--PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQI 190
               P  P C     +  C PPP + + + T      ++PG  V Y C+  Y L G   +
Sbjct: 734 NKWEPELPSC-----SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASM 788

Query: 191 TCR-NGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYS---RTGDIVEFVCKSGY 245
            C   G WS       P   + E+    +   +  N + L+    + G  V+FVC  G+
Sbjct: 789 RCTPQGDWS-------PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGF 840



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 37/114 (32%), Positives = 51/114 (44%), Gaps = 6/114 (5%)

Query: 134  WSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC 192
            WS+P P+C  ++ A  C  PP I NG      +S+Y PG ++ Y C   Y L G   I C
Sbjct: 1833 WSSPAPRCELSVPAA-CPHPPKIQNGHYIGGHVSLYLPGMTISYICDPGYLLVGKGFIFC 1891

Query: 193  RN-GQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
             + G WS+          S  +    N   K    +K+Y   GD V   C+ GY
Sbjct: 1892 TDQGIWSQLDHYCKEVNCSFPLF--MNGISKELEMKKVY-HYGDYVTLKCEDGY 1942


>gi|168693643 decay accelerating factor for complement isoform 2
           precursor [Homo sapiens]
          Length = 440

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 59/194 (30%), Positives = 84/194 (43%), Gaps = 26/194 (13%)

Query: 23  CDFP-KINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV-SPSKSFWTRITCAEE-GWSP 79
           C+ P ++N   L  ++ Y   +  P G V  Y C   +   PS S   ++TC +   WS 
Sbjct: 98  CEVPTRLNSASL--KQPYITQNYFPVGTVVEYECRPGYRREPSLS--PKLTCLQNLKWST 153

Query: 80  TPKCLRLCFFPF---VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG--- 133
             +  +    P    + NG  +  G   L G T+   CNTGY+L  + ++  C+  G   
Sbjct: 154 AVEFCKKKSCPNPGEIRNGQIDVPGGI-LFGATISFSCNTGYKLFGSTSSF-CLISGSSV 211

Query: 134 -WSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQIT 191
            WS P P+CR       C  PP IDNG I       Y    SV Y C   + + G + I 
Sbjct: 212 QWSDPLPECREIY----CPAPPQIDNG-IIQGERDHYGYRQSVTYACNKGFTMIGEHSIY 266

Query: 192 CR----NGQWSEPP 201
           C      G+WS PP
Sbjct: 267 CTVNNDEGEWSGPP 280



 Score = 36.2 bits (82), Expect = 0.031
 Identities = 28/113 (24%), Positives = 48/113 (42%), Gaps = 7/113 (6%)

Query: 149 CGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQL---EGNNQITCRNGQWSEPPKCLD 205
           CG PP + N        + +   + + Y+C+  +     E ++ I  +  QWS+  +   
Sbjct: 36  CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEF-- 93

Query: 206 PCVISQEIMEKYN-IKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMC 257
            C  S E+  + N   LK     + Y   G +VE+ C+ GY    S S +  C
Sbjct: 94  -CNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTC 145


>gi|10835143 decay accelerating factor for complement isoform 1
           preproprotein [Homo sapiens]
          Length = 381

 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 59/194 (30%), Positives = 84/194 (43%), Gaps = 26/194 (13%)

Query: 23  CDFP-KINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV-SPSKSFWTRITCAEE-GWSP 79
           C+ P ++N   L  ++ Y   +  P G V  Y C   +   PS S   ++TC +   WS 
Sbjct: 98  CEVPTRLNSASL--KQPYITQNYFPVGTVVEYECRPGYRREPSLS--PKLTCLQNLKWST 153

Query: 80  TPKCLRLCFFPF---VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG--- 133
             +  +    P    + NG  +  G   L G T+   CNTGY+L  + ++  C+  G   
Sbjct: 154 AVEFCKKKSCPNPGEIRNGQIDVPGGI-LFGATISFSCNTGYKLFGSTSSF-CLISGSSV 211

Query: 134 -WSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQIT 191
            WS P P+CR       C  PP IDNG I       Y    SV Y C   + + G + I 
Sbjct: 212 QWSDPLPECREIY----CPAPPQIDNG-IIQGERDHYGYRQSVTYACNKGFTMIGEHSIY 266

Query: 192 CR----NGQWSEPP 201
           C      G+WS PP
Sbjct: 267 CTVNNDEGEWSGPP 280



 Score = 36.2 bits (82), Expect = 0.031
 Identities = 28/113 (24%), Positives = 48/113 (42%), Gaps = 7/113 (6%)

Query: 149 CGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQL---EGNNQITCRNGQWSEPPKCLD 205
           CG PP + N        + +   + + Y+C+  +     E ++ I  +  QWS+  +   
Sbjct: 36  CGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEF-- 93

Query: 206 PCVISQEIMEKYN-IKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMC 257
            C  S E+  + N   LK     + Y   G +VE+ C+ GY    S S +  C
Sbjct: 94  -CNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTC 145


>gi|153266841 apolipoprotein H precursor [Homo sapiens]
          Length = 345

 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 57/208 (27%), Positives = 84/208 (40%), Gaps = 18/208 (8%)

Query: 72  CAEEG-WSPT-PKCLRL-CFFPFVENG-----HSESSGQTHLEGDTVQIICNTGYRLQNN 123
           C EEG WSP  P C  + C  P +        +  S+G   L  DT    C   + +  N
Sbjct: 124 CTEEGKWSPELPVCAPIICPPPSIPTFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGN 183

Query: 124 ENNISCVERG-WSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLY 182
           +  I+C   G W+  P+CR      KC  P   DNG +               + C + Y
Sbjct: 184 DT-ITCTTHGNWTKLPECREV----KCPFPSRPDNGFVNYPAKPTLYYKDKATFGCHDGY 238

Query: 183 QLEGNNQITC-RNGQWSEPPKCLDPC--VISQEIMEKYNIKLKWTNQQKLYSRTGDIVEF 239
            L+G  +I C + G WS  P C   C   + +  +     ++K   + K     GD V F
Sbjct: 239 SLDGPEEIECTKLGNWSAMPSCKASCKVPVKKATVVYQGERVKIQEKFKNGMLHGDKVSF 298

Query: 240 VCKSGYHPTKSHSFRAMCQNGKLVYPSC 267
            CK+      S++  A C +G +  P C
Sbjct: 299 FCKN-KEKKCSYTEDAQCIDGTIEVPKC 325



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 57/185 (30%), Positives = 82/185 (44%), Gaps = 36/185 (19%)

Query: 41  PFSQVPTGEVFY-------YSCEYNFVSPSKSFWTRITCAEEGWSP--TPKCL-RLC-FF 89
           PFS V   + FY       YSC+  +VS  +    +  C   G  P  T KC  R+C F 
Sbjct: 30  PFSTVVPLKTFYEPGEEITYSCKPGYVS--RGGMRKFICPLTGLWPINTLKCTPRVCPFA 87

Query: 90  PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP--PKCRSTISAE 147
             +ENG    +  T    +T+   CNTG+ L N  ++  C E G  +P  P C   I   
Sbjct: 88  GILENGAVRYT--TFEYPNTISFSCNTGFYL-NGADSAKCTEEGKWSPELPVCAPIIC-- 142

Query: 148 KCGPPPPIDNGDITSFLLSVYAPGS--------SVEYQCQNLYQLEGNNQITC-RNGQWS 198
              PPP I     T   L VY P +        +  ++C   + + GN+ ITC  +G W+
Sbjct: 143 ---PPPSIP----TFATLRVYKPSAGNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNWT 195

Query: 199 EPPKC 203
           + P+C
Sbjct: 196 KLPEC 200


>gi|148539593 sushi domain containing 4 isoform a [Homo sapiens]
          Length = 490

 Score = 56.6 bits (135), Expect = 2e-08
 Identities = 60/239 (25%), Positives = 108/239 (45%), Gaps = 34/239 (14%)

Query: 44  QVPTGEVFY------YSCEYNFVSPSKSFWTRITCAEE-----GWSPTPKCLRL---CFF 89
           + P+G VF+      + C+  F        T+  C +      GW P+   + +   C  
Sbjct: 68  RTPSGGVFFEGSVARFHCQDGFKLKGA---TKRLCLKHFNGTLGWIPSDNSICVQEDCRI 124

Query: 90  PFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNE--NNIS-CVERG-WSTPPKCRSTIS 145
           P +E+  +E   +T+  G+ + I C+ G++++  +  N +S C + G W+  P C+    
Sbjct: 125 PQIED--AEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQG--- 179

Query: 146 AEKCGPPPPIDNGDIT-SFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWSE-PPK 202
              C  P    NG +  S L + +  G+ + Y+C   ++L+G+  + C +N  WS  PP+
Sbjct: 180 ---CLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPR 236

Query: 203 CLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGK 261
           CL   V     M  +   +      + Y+  G +VEF C  GY  T  + +   CQ G+
Sbjct: 237 CLALEVCPLPPMVSHGDFVCHPRPCERYNH-GTVVEFYCDPGYSLTSDYKY-ITCQYGE 293



 Score = 28.5 bits (62), Expect = 6.5
 Identities = 26/97 (26%), Positives = 40/97 (41%), Gaps = 11/97 (11%)

Query: 46  PTGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WSPTP-KCLRL--CFFP-FVENGH---S 97
           P G V  Y C   F     ++   + C +   WS +P +CL L  C  P  V +G     
Sbjct: 201 PVGTVISYRCFPGFKLDGSAY---LECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCH 257

Query: 98  ESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
               + +  G  V+  C+ GY L ++   I+C    W
Sbjct: 258 PRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEW 294


>gi|62912468 complement component 4 binding protein, beta chain
           isoform 1 precursor [Homo sapiens]
          Length = 252

 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 42/143 (29%), Positives = 65/143 (45%), Gaps = 14/143 (9%)

Query: 73  AEEGWSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCV 130
           A + W  T    RL  C  P + NG   SSG  ++  D +  +CN  Y L+ +  +    
Sbjct: 65  ASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVS-DKITFMCNDHYILKGSNRSQCLE 123

Query: 131 ERGWSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQ 189
           +  W+ P P C+S      C PP    +G    F  + +  GS++ Y C++ Y L G  +
Sbjct: 124 DHTWAPPFPICKS----RDCDPPGNPVHG---YFEGNNFTLGSTISYYCEDRYYLVGVQE 176

Query: 190 ITCRNGQWSEPPKCLDPCVISQE 212
             C +G+WS     L  C + QE
Sbjct: 177 QQCVDGEWS---SALPVCKLIQE 196


>gi|62912466 complement component 4 binding protein, beta chain
           isoform 2 precursor [Homo sapiens]
          Length = 251

 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 42/143 (29%), Positives = 65/143 (45%), Gaps = 14/143 (9%)

Query: 73  AEEGWSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCV 130
           A + W  T    RL  C  P + NG   SSG  ++  D +  +CN  Y L+ +  +    
Sbjct: 64  ASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVS-DKITFMCNDHYILKGSNRSQCLE 122

Query: 131 ERGWSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQ 189
           +  W+ P P C+S      C PP    +G    F  + +  GS++ Y C++ Y L G  +
Sbjct: 123 DHTWAPPFPICKS----RDCDPPGNPVHG---YFEGNNFTLGSTISYYCEDRYYLVGVQE 175

Query: 190 ITCRNGQWSEPPKCLDPCVISQE 212
             C +G+WS     L  C + QE
Sbjct: 176 QQCVDGEWS---SALPVCKLIQE 195


>gi|62912464 complement component 4 binding protein, beta chain
           isoform 1 precursor [Homo sapiens]
          Length = 252

 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 42/143 (29%), Positives = 65/143 (45%), Gaps = 14/143 (9%)

Query: 73  AEEGWSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCV 130
           A + W  T    RL  C  P + NG   SSG  ++  D +  +CN  Y L+ +  +    
Sbjct: 65  ASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVS-DKITFMCNDHYILKGSNRSQCLE 123

Query: 131 ERGWSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQ 189
           +  W+ P P C+S      C PP    +G    F  + +  GS++ Y C++ Y L G  +
Sbjct: 124 DHTWAPPFPICKS----RDCDPPGNPVHG---YFEGNNFTLGSTISYYCEDRYYLVGVQE 176

Query: 190 ITCRNGQWSEPPKCLDPCVISQE 212
             C +G+WS     L  C + QE
Sbjct: 177 QQCVDGEWS---SALPVCKLIQE 196


>gi|62912462 complement component 4 binding protein, beta chain
           isoform 2 precursor [Homo sapiens]
          Length = 251

 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 42/143 (29%), Positives = 65/143 (45%), Gaps = 14/143 (9%)

Query: 73  AEEGWSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCV 130
           A + W  T    RL  C  P + NG   SSG  ++  D +  +CN  Y L+ +  +    
Sbjct: 64  ASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVS-DKITFMCNDHYILKGSNRSQCLE 122

Query: 131 ERGWSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQ 189
           +  W+ P P C+S      C PP    +G    F  + +  GS++ Y C++ Y L G  +
Sbjct: 123 DHTWAPPFPICKS----RDCDPPGNPVHG---YFEGNNFTLGSTISYYCEDRYYLVGVQE 175

Query: 190 ITCRNGQWSEPPKCLDPCVISQE 212
             C +G+WS     L  C + QE
Sbjct: 176 QQCVDGEWS---SALPVCKLIQE 195


>gi|4502505 complement component 4 binding protein, beta chain
           isoform 1 precursor [Homo sapiens]
          Length = 252

 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 42/143 (29%), Positives = 65/143 (45%), Gaps = 14/143 (9%)

Query: 73  AEEGWSPTPKCLRL--CFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCV 130
           A + W  T    RL  C  P + NG   SSG  ++  D +  +CN  Y L+ +  +    
Sbjct: 65  ASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVS-DKITFMCNDHYILKGSNRSQCLE 123

Query: 131 ERGWSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQ 189
           +  W+ P P C+S      C PP    +G    F  + +  GS++ Y C++ Y L G  +
Sbjct: 124 DHTWAPPFPICKS----RDCDPPGNPVHG---YFEGNNFTLGSTISYYCEDRYYLVGVQE 176

Query: 190 ITCRNGQWSEPPKCLDPCVISQE 212
             C +G+WS     L  C + QE
Sbjct: 177 QQCVDGEWS---SALPVCKLIQE 196


>gi|148922949 complement component (3b/4b) receptor 1-like [Homo
           sapiens]
          Length = 569

 Score = 55.5 bits (132), Expect = 5e-08
 Identities = 60/231 (25%), Positives = 92/231 (39%), Gaps = 51/231 (22%)

Query: 44  QVPTGEVFYYSCE-------YNFVSPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGH 96
           + P G    Y C        ++ +    S WT         S   KC R        N  
Sbjct: 54  EFPIGTYLNYECRPGYSGRPFSIICLKNSVWT---------SAKDKCKRKS----CRNPP 100

Query: 97  SESSGQTHLEGDT-----VQIICNTGYRLQNNENNISCVERG----WSTP-PKCRSTISA 146
              +G  H+  D      ++  C  GYRL  + ++ +C+  G    W    P C   I  
Sbjct: 101 DPVNGMAHVIKDIQFRSQIKYSCPKGYRLIGS-SSATCIISGNTVIWDNKTPVCDRII-- 157

Query: 147 EKCGPPPPIDNGDITSFLLSVYAPGSSVEYQC------QNLYQLEGNNQITCRN-----G 195
             CG PP I NGD TS     +  GS V Y C      + +++L G   I C +     G
Sbjct: 158 --CGLPPTIANGDFTSISREYFHYGSVVTYHCNLGSRGKKVFELVGEPSIYCTSKDDQVG 215

Query: 196 QWSEP-PKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
            WS P P+C+ P   +   +E     +  ++ + L+S   ++VEF C+ G+
Sbjct: 216 IWSGPAPQCIIPNKCTPPNVEN---GILVSDNRSLFS-LNEVVEFRCQPGF 262



 Score = 51.6 bits (122), Expect = 7e-07
 Identities = 52/209 (24%), Positives = 86/209 (41%), Gaps = 29/209 (13%)

Query: 77  WS-PTPKCL--RLCFFPFVENGHSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVER 132
           WS P P+C+    C  P VENG   S  ++     + V+  C  G+ ++   +++ C   
Sbjct: 217 WSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFGMKG-PSHVKCQAL 275

Query: 133 GWSTP--PKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQI 190
               P  P C     +  C PPP + + + T      ++PG  V Y C+  Y L G+  +
Sbjct: 276 NKWEPELPSC-----SRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGSTYL 330

Query: 191 TCR-NGQWS-EPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYS---RTGDIVEFVCKSGY 245
            C   G WS   P+C        E+    +   +  N   L+    + G  V+FVC  G+
Sbjct: 331 HCTPQGDWSPAAPRC--------EVKSCDDFLGQLPNGHVLFPLNLQLGAKVDFVCDEGF 382

Query: 246 HPTKSHSFRAMCQNGKLVY----PSCEEK 270
               S +   +    + ++    P CE K
Sbjct: 383 QLKGSSASYCVLAGMESLWNSSVPVCERK 411



 Score = 40.4 bits (93), Expect = 0.002
 Identities = 54/192 (28%), Positives = 73/192 (38%), Gaps = 38/192 (19%)

Query: 44  QVPTGEVFY-----------YSCEYNF-VSPSKSFWTRITCAEEGW-SPTPKCLRL-CFF 89
           Q+P G V +           + C+  F +  S + +  +   E  W S  P C R  C  
Sbjct: 356 QLPNGHVLFPLNLQLGAKVDFVCDEGFQLKGSSASYCVLAGMESLWNSSVPVCERKSCET 415

Query: 90  PFVE-NGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----WST-PPKCRST 143
           P V  NG        H+ G  +   C TG+RL  + ++  C+  G    WS  PP C+  
Sbjct: 416 PPVPVNGMVHVITDIHV-GSRINYSCTTGHRLIGH-SSAECILSGNTAHWSMKPPICQQI 473

Query: 144 ISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQ------NLYQLEGNNQITCR---- 193
                C  PP I NG  T   L     G  V Y C         + L G + I       
Sbjct: 474 F----CPNPPAILNGRHTGTPLGDIPYGKEVSYTCDPHPDRGMTFNLIGESTIRRTSEPH 529

Query: 194 -NGQWSEP-PKC 203
            NG WS P P+C
Sbjct: 530 GNGVWSSPAPRC 541


>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
          Length = 3565

 Score = 53.9 bits (128), Expect = 1e-07
 Identities = 50/160 (31%), Positives = 67/160 (41%), Gaps = 16/160 (10%)

Query: 53   YSCEYNFVSPSKSFWTRITCAEEGWS-PTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQ 111
            Y C   F     S   RI   +  WS  TP C+ +         H  ++G      D V 
Sbjct: 2705 YQCNPGFRLVGTS--VRICLQDHKWSGQTPVCVPITCGHPGNPAHGFTNGSEFNLNDVVN 2762

Query: 112  IICNTGYRLQNNENNISCVERG-WSTP-PKCRSTISAEKCGPPPPIDNG---DITSFLLS 166
              CNTGY LQ   +   C   G WS+P P CR       C  P  ++N       +F  S
Sbjct: 2763 FTCNTGYLLQ-GVSRAQCRSNGQWSSPLPTCR----VVNCSDPGFVENAIRHGQQNFPES 2817

Query: 167  VYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWSEP-PKCL 204
             +  G S+ Y C+  + L G++ +TC  NG W    PKCL
Sbjct: 2818 -FEYGMSILYHCKKGFYLLGSSALTCMANGLWDRSLPKCL 2856



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 34/101 (33%), Positives = 49/101 (48%), Gaps = 12/101 (11%)

Query: 109  TVQIICNTGYRLQN-NENNISCVERGWSTP--PKCRSTISAEKCGPPPPIDNGDITSFLL 165
            TV   CN GY ++      I C + G   P  P C++ +    C  PPP+ NG +     
Sbjct: 3059 TVSYQCNPGYVMEAVTSATIRCTKDGRWNPSKPVCKAVL----CPQPPPVQNGTVEG--- 3111

Query: 166  SVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQW-SEPPKCL 204
            S +  GSS+ Y C + YQL  +  ++C   G W  E P+CL
Sbjct: 3112 SDFRWGSSISYSCMDGYQLSHSAILSCEGRGVWKGEIPQCL 3152



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 54/202 (26%), Positives = 86/202 (42%), Gaps = 22/202 (10%)

Query: 53   YSCEYNFVSPSKSFWTRITCAEEG-WSPTPKCLRLCFFPF---VENGHSESSGQTHLEGD 108
            Y C   +V  + +  T I C ++G W+P+    +    P    V+NG  E  G     G 
Sbjct: 3062 YQCNPGYVMEAVTSAT-IRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVE--GSDFRWGS 3118

Query: 109  TVQIICNTGYRLQNNENNISCVERG-WSTP-PKCRSTISAEKCGPPPPIDNGDITSFLLS 166
            ++   C  GY+L ++   +SC  RG W    P+C        CG P     G ++     
Sbjct: 3119 SISYSCMDGYQLSHSAI-LSCEGRGVWKGEIPQCLPVF----CGDPGIPAEGRLSG---K 3170

Query: 167  VYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWSE-PPKCLDPCVISQEIMEKYNIKLKWT 224
             +   S V +QC++ + L G+++  C+ +G WS   P C+DP        +         
Sbjct: 3171 SFTYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDPA--HNTCPDPGTPHFGIQ 3228

Query: 225  NQQKLYSRTGDIVEFVCKSGYH 246
            N  + Y   G  V F C+ GYH
Sbjct: 3229 NSSRGYE-VGSTVFFRCRKGYH 3249



 Score = 47.8 bits (112), Expect = 1e-05
 Identities = 36/115 (31%), Positives = 46/115 (40%), Gaps = 12/115 (10%)

Query: 92   VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWS-TPPKCRSTISAEKCG 150
            + NGH    G ++   DTV   CN G+RL      I   +  WS   P C          
Sbjct: 2687 IVNGHISGDGFSYR--DTVVYQCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGN 2744

Query: 151  PPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWSEP-PKC 203
            P     NG       S +     V + C   Y L+G ++  CR NGQWS P P C
Sbjct: 2745 PAHGFTNG-------SEFNLNDVVNFTCNTGYLLQGVSRAQCRSNGQWSSPLPTC 2792



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 52/189 (27%), Positives = 80/189 (42%), Gaps = 27/189 (14%)

Query: 67   WTRITCAEEG-WS-----PTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL 120
            W  + C   G W+     P+ + +      F  NG+    G   + G T    CNTGY L
Sbjct: 2598 WRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNK--IGTLTVYGATAIFTCNTGYTL 2655

Query: 121  QNNENNISCVERG-WS-TPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQC 178
              +     C+  G WS +  +C     A  CG P PI NG I+      ++   +V YQC
Sbjct: 2656 VGSHVR-ECLANGLWSGSETRCL----AGHCGSPDPIVNGHISG---DGFSYRDTVVYQC 2707

Query: 179  QNLYQLEGNN-QITCRNGQWS-EPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDI 236
               ++L G + +I  ++ +WS + P C+ P           N    +TN  +      D+
Sbjct: 2708 NPGFRLVGTSVRICLQDHKWSGQTPVCV-PITCG----HPGNPAHGFTNGSEF--NLNDV 2760

Query: 237  VEFVCKSGY 245
            V F C +GY
Sbjct: 2761 VNFTCNTGY 2769



 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 24/65 (36%), Positives = 36/65 (55%), Gaps = 7/65 (10%)

Query: 147  EKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNG---QWSEP-PK 202
            + C  PPP  NG + +   S Y+ G SV ++C   Y L G+  +TC++G    W+ P P+
Sbjct: 2086 QNCPDPPPFQNGYMIN---SDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPR 2142

Query: 203  CLDPC 207
            C  PC
Sbjct: 2143 CDAPC 2147



 Score = 39.7 bits (91), Expect = 0.003
 Identities = 47/166 (28%), Positives = 71/166 (42%), Gaps = 21/166 (12%)

Query: 43   SQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WS-PTPKCLRL-CFFP-FVENG--H 96
            S+    +V  ++C   ++    S   R  C   G WS P P C  + C  P FVEN   H
Sbjct: 2753 SEFNLNDVVNFTCNTGYLLQGVS---RAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRH 2809

Query: 97   SESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVERG-WSTP-PKCRSTISAEKCGPPP 153
             + +     E G ++   C  G+ L  + + ++C+  G W    PKC     A  CG P 
Sbjct: 2810 GQQNFPESFEYGMSILYHCKKGFYLLGS-SALTCMANGLWDRSLPKCL----AISCGHPG 2864

Query: 154  PIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS 198
               N  +T  L +    G+ V Y C+    L GN+   C+ +  WS
Sbjct: 2865 VPANAVLTGELFTY---GAVVHYSCRGSESLIGNDTRVCQEDSHWS 2907



 Score = 35.0 bits (79), Expect = 0.069
 Identities = 36/124 (29%), Positives = 51/124 (41%), Gaps = 15/124 (12%)

Query: 145  SAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNG-----QW-S 198
            +A  C    P+ NG I +   +  A GS V Y C+  Y++ G++  TCR       QW S
Sbjct: 2429 AAPYCSLTHPLKNGGILN--RTAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDS 2486

Query: 199  EPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQ 258
              P C     +S  I E         N+  L S+    V + C  G+    S    A+CQ
Sbjct: 2487 LTPLCQ---AVSCGIPESPGNGSFTGNEFTLDSK----VVYECHEGFKLESSQQATAVCQ 2539

Query: 259  NGKL 262
               L
Sbjct: 2540 EDGL 2543



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 19/61 (31%), Positives = 31/61 (50%), Gaps = 7/61 (11%)

Query: 154  PIDNGDITSFLLSV---YAPGSSVEYQCQNLYQLEGNNQITCRNG---QWSEP-PKCLDP 206
            P D+  + +F   +   +  G S+ + C   Y+LEG  ++TC  G    WS P P+C+  
Sbjct: 1045 PCDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCVAE 1104

Query: 207  C 207
            C
Sbjct: 1105 C 1105



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 26/71 (36%), Positives = 33/71 (46%), Gaps = 8/71 (11%)

Query: 142  STISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-----RNGQ 196
            ST  A  C  P    NG  T +  S  A G +V +QC   YQL+G  +ITC     R   
Sbjct: 1385 STSIAATCNDPGMPQNG--TRYGDSREA-GDTVTFQCDPGYQLQGQAKITCVQLNNRFFW 1441

Query: 197  WSEPPKCLDPC 207
              +PP C+  C
Sbjct: 1442 QPDPPTCIAAC 1452



 Score = 33.1 bits (74), Expect = 0.26
 Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 5/61 (8%)

Query: 149 CGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWS-EPPKCLDP 206
           CG P     G  T    S +  G ++ ++C   ++L G   ITC +N QWS   P C+  
Sbjct: 528 CGDPGIPAYGKRTG---SSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFS 584

Query: 207 C 207
           C
Sbjct: 585 C 585



 Score = 32.7 bits (73), Expect = 0.34
 Identities = 15/48 (31%), Positives = 27/48 (56%), Gaps = 6/48 (12%)

Query: 166  SVYAPGSSVEYQCQNLYQLEGNNQITCRN-----GQWSEP-PKCLDPC 207
            S ++ GS V ++C   Y L+G+  + C++      QW++  P C+ PC
Sbjct: 1756 SEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSCVVPC 1803



 Score = 32.3 bits (72), Expect = 0.45
 Identities = 24/69 (34%), Positives = 31/69 (44%), Gaps = 13/69 (18%)

Query: 147  EKCGPPPPIDNGDI--TSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEP---- 200
            E C  P  I NG    T F L     GS++ YQC + Y++   + ITC  G   +P    
Sbjct: 1563 EACFDPGNIMNGTRVGTDFKL-----GSTITYQCDSGYKILDPSSITCVIGADGKPSWDQ 1617

Query: 201  --PKCLDPC 207
              P C  PC
Sbjct: 1618 VLPSCNAPC 1626



 Score = 31.6 bits (70), Expect = 0.76
 Identities = 19/56 (33%), Positives = 26/56 (46%), Gaps = 6/56 (10%)

Query: 101  GQTHLEGDTVQIICNTGYRLQNNENNISCVERG----WS-TPPKCRSTISAEKCGP 151
            G +   GDTV   C+ GY+LQ  +  I+CV+      W   PP C +       GP
Sbjct: 1405 GDSREAGDTVTFQCDPGYQLQ-GQAKITCVQLNNRFFWQPDPPTCIAACGGNLTGP 1459



 Score = 31.2 bits (69), Expect = 1.00
 Identities = 14/38 (36%), Positives = 20/38 (52%), Gaps = 4/38 (10%)

Query: 174  VEYQCQNLYQLEGNNQITCRNGQ---WSEP-PKCLDPC 207
            V Y C   Y + G+N +TC +G    W +P P C+  C
Sbjct: 1241 VLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIAEC 1278



 Score = 31.2 bits (69), Expect = 1.00
 Identities = 15/47 (31%), Positives = 25/47 (53%), Gaps = 1/47 (2%)

Query: 147  EKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR 193
            +KC PPP +   ++ +     +  G  V+YQC   Y L G + +TC+
Sbjct: 2257 KKCQPPPAVPQAEMLTED-DDFEIGDFVKYQCHPGYTLVGTDILTCK 2302



 Score = 30.0 bits (66), Expect = 2.2
 Identities = 14/44 (31%), Positives = 23/44 (52%), Gaps = 4/44 (9%)

Query: 168  YAPGSSVEYQCQNLYQLEGNNQITCRNG---QWSEP-PKCLDPC 207
            Y     + +QC+  Y L+G + I+C  G   +W+ P P C+  C
Sbjct: 1932 YMVNDVLSFQCEPGYTLQGRSHISCMPGTVRRWNYPSPLCIATC 1975



 Score = 28.9 bits (63), Expect = 4.9
 Identities = 9/23 (39%), Positives = 18/23 (78%)

Query: 171 GSSVEYQCQNLYQLEGNNQITCR 193
           G++V++ C++ Y L+G+  ITC+
Sbjct: 369 GANVQFSCEDNYVLQGSKSITCQ 391



 Score = 28.9 bits (63), Expect = 4.9
 Identities = 37/156 (23%), Positives = 60/156 (38%), Gaps = 12/156 (7%)

Query: 48   GEVFYYSCEYNFVSPSKSFWTRITCAEEG-WS-PTPKCLRL-CFFPFVENGHSESSGQTH 104
            G    YSC   +     +    ++C   G W    P+CL + C  P +       SG++ 
Sbjct: 3117 GSSISYSCMDGYQLSHSAI---LSCEGRGVWKGEIPQCLPVFCGDPGIP-AEGRLSGKSF 3172

Query: 105  LEGDTVQIICNTGYRLQNNENNISCVERGWS-TPPKCRSTISAEKCGPPPPIDNGDITSF 163
                 V   C + + L  +   +   +  WS   P C     A    P P   +  I + 
Sbjct: 3173 TYKSEVFFQCKSPFILVGSSRRVCQADGTWSGIQPTCIDP--AHNTCPDPGTPHFGIQNS 3230

Query: 164  LLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWS 198
                Y  GS+V ++C+  Y ++G+   TC  N  WS
Sbjct: 3231 SRG-YEVGSTVFFRCRKGYHIQGSTTRTCLANLTWS 3265


>gi|38045915 pregnancy-associated plasma protein A preproprotein [Homo
            sapiens]
          Length = 1627

 Score = 52.0 bits (123), Expect = 5e-07
 Identities = 49/208 (23%), Positives = 80/208 (38%), Gaps = 42/208 (20%)

Query: 92   VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENN------------ISCVERGWSTPPK 139
            VEN     S      G    + C TGY LQ   ++            ++C E  W+    
Sbjct: 1220 VENASLNCSSSDRYHGAQCTVSCRTGYVLQIRRDDELIKSQTGPSVTVTCTEGKWNKQVA 1279

Query: 140  CRSTISAEKCGPPPPIDNGDITSFLLSVYAP-----GSSVEYQCQNLYQLEGNNQ-ITC- 192
            C        C  P   D+  +  +  S   P     GS   +QC++  QL+GNN  +TC 
Sbjct: 1280 CEPV----DCSIP---DHHQV--YAASFSCPEGTTFGSQCSFQCRHPAQLKGNNSLLTCM 1330

Query: 193  RNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYH------ 246
             +G WS P    +   ++   +   +++     + K   + G   ++ CK GYH      
Sbjct: 1331 EDGLWSFPEALCELMCLAPPPVPNADLQTARCRENK--HKVGSFCKYKCKPGYHVPGSSR 1388

Query: 247  PTKSHSFRAMC------QNGKLVYPSCE 268
             +K  +F+  C      Q G  V  +C+
Sbjct: 1389 KSKKRAFKTQCTQDGSWQEGACVPVTCD 1416



 Score = 35.4 bits (80), Expect = 0.053
 Identities = 41/169 (24%), Positives = 63/169 (37%), Gaps = 35/169 (20%)

Query: 46   PTGEVFYYSCEYNFVSPS--KSFWTRITCAEEG-WS-PTPKCLRLCFFPF-VENGHSESS 100
            P G  F   C +    P+  K   + +TC E+G WS P   C  +C  P  V N   +++
Sbjct: 1301 PEGTTFGSQCSFQCRHPAQLKGNNSLLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTA 1360

Query: 101  G---QTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEK-------CG 150
                  H  G   +  C  GY +  +       +R + T  +C    S ++       C 
Sbjct: 1361 RCRENKHKVGSFCKYKCKPGYHVPGSSRKSK--KRAFKT--QCTQDGSWQEGACVPVTCD 1416

Query: 151  PPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSE 199
            PPPP  +G                 YQC N +Q     +I C +   S+
Sbjct: 1417 PPPPKFHG----------------LYQCTNGFQFNSECRIKCEDSDASQ 1449


>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
          Length = 3487

 Score = 51.2 bits (121), Expect = 9e-07
 Identities = 43/144 (29%), Positives = 66/144 (45%), Gaps = 16/144 (11%)

Query: 72   CAEEG-WSPT-PKC----LRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNEN 125
            C  +G WS T P C    L  C  P V     +++ Q +  G TV   C  GY LQ +  
Sbjct: 3110 CQSDGTWSGTQPSCIDPTLTTCADPGVPQFGIQNNSQGYQVGSTVLFRCQKGYLLQGSTT 3169

Query: 126  NISCVERGWS-TPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQL 184
                    WS TPP C        C  P    + ++ +  L + + G ++ Y CQ  + L
Sbjct: 3170 RTCLPNLTWSGTPPDC----VPHHCRQPETPTHANVGA--LDLPSMGYTLIYSCQEGFSL 3223

Query: 185  EGNNQ-ITCR-NGQWS-EPPKCLD 205
            +G ++  TC+ +G W+ +PP CL+
Sbjct: 3224 KGGSEHRTCKADGSWTGKPPICLE 3247



 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 37/100 (37%), Positives = 52/100 (52%), Gaps = 12/100 (12%)

Query: 109  TVQIICNTGYRLQNNENNI-SCV-ERGWS-TPPKCRSTISAEKCGPPPPIDNGDITSFLL 165
            TV   C  GY ++++  ++ SC  +R W+ T P C++ +    C PPP I NG +     
Sbjct: 2973 TVTYQCVPGYMMESHRVSVLSCTKDRTWNGTKPVCKALM----CKPPPLIPNGKVVG--- 3025

Query: 166  SVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKC 203
            S +  GSSV Y C   YQL      TC  NG W+ E P+C
Sbjct: 3026 SDFMWGSSVTYACLEGYQLSLPAVFTCEGNGSWTGELPQC 3065



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 32/96 (33%), Positives = 46/96 (47%), Gaps = 17/96 (17%)

Query: 126  NISCVERGWSTPPKCRSTI----------SAEKCGPPPPIDNGDITSFLLSVYAPGSSVE 175
            ++S +ER  STPP   S +            ++C  P P  NG +     + Y  G SV 
Sbjct: 2090 DLSELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRG---AGYNVGQSVT 2146

Query: 176  YQCQNLYQLEGNNQITCRNG---QWSEP-PKCLDPC 207
            ++C   YQL G+  +TC++G    W  P PKC  PC
Sbjct: 2147 FECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPC 2182



 Score = 44.7 bits (104), Expect = 9e-05
 Identities = 44/143 (30%), Positives = 60/143 (41%), Gaps = 16/143 (11%)

Query: 70   ITCAEEG-WS-----PTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNN 123
            I C   G WS     PT + +     P   NGH    G   + G T    CN+GY L  +
Sbjct: 2636 IRCQANGKWSLGDSTPTCRIISCGELPIPPNGHR--IGTLSVYGATAIFSCNSGYTLVGS 2693

Query: 124  ENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQ 183
                 C+  G  +  + R    A  CG P PI NG I       Y+   SV YQC   ++
Sbjct: 2694 RVR-ECMANGLWSGSEVRCL--AGHCGTPEPIVNGHING---ENYSYRGSVVYQCNAGFR 2747

Query: 184  LEGNNQITC-RNGQWS-EPPKCL 204
            L G +   C ++  WS + P C+
Sbjct: 2748 LIGMSVRICQQDHHWSGKTPFCV 2770



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 47/178 (26%), Positives = 70/178 (39%), Gaps = 22/178 (12%)

Query: 96   HSESSGQTHLE-GDTVQIICNTGYRLQNNENNISCVE--RGWSTPPKCRSTISAEKCGPP 152
            H    GQT  + G ++   CN GYRL  +   I C    +G+    +      A  CG P
Sbjct: 2476 HGFILGQTSTQPGGSIHFGCNAGYRLVGHSMAI-CTRHPQGYHLWSEAIPLCQALSCGLP 2534

Query: 153  PPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR---NGQWSE---PPKCLDP 206
                NG +       Y  G+   Y C   Y L+   + T      G WS    PP+C+  
Sbjct: 2535 EAPKNGMVFG---KEYTVGTKAMYSCSEGYHLQAGAEATAECLDTGLWSNRNVPPQCVPV 2591

Query: 207  CV--ISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQ-NGK 261
                +S   +E    +L +  Q +  ++    +  +C  GY+ T     R  CQ NGK
Sbjct: 2592 TCPDVSSISVEHGRWRLIFETQYQFQAQ----LMLICDPGYYYTGQRVIR--CQANGK 2643



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 24/67 (35%), Positives = 31/67 (46%), Gaps = 9/67 (13%)

Query: 147  EKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQ-----WSEP- 200
            E C  P  I NG      L +   GSSV Y C   Y++EG + ++C  G      W+ P 
Sbjct: 1556 ESCFDPGSIKNGTRVGSDLKL---GSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPR 1612

Query: 201  PKCLDPC 207
            P C  PC
Sbjct: 1613 PVCTAPC 1619



 Score = 35.4 bits (80), Expect = 0.053
 Identities = 24/77 (31%), Positives = 34/77 (44%), Gaps = 7/77 (9%)

Query: 143  TISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNG---QWS- 198
            T+    C  P    NG  T      Y     V +QC+  Y L+G+  I+C  G   +W+ 
Sbjct: 1903 TVGLSSCPEPAVPSNGVKTG---ERYLVNDVVSFQCEPGYALQGHAHISCMPGTVRRWNY 1959

Query: 199  EPPKCLDPCVISQEIME 215
             PP C+  C  + E ME
Sbjct: 1960 PPPLCIAQCGGTVEEME 1976



 Score = 35.4 bits (80), Expect = 0.053
 Identities = 44/174 (25%), Positives = 65/174 (37%), Gaps = 21/174 (12%)

Query: 92   VENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWS-TPPKCRSTISAEKCG 150
            + NGH   +G+ +    +V   CN G+RL      I   +  WS   P C          
Sbjct: 2722 IVNGHI--NGENYSYRGSVVYQCNAGFRLIGMSVRICQQDHHWSGKTPFCVLVSCGHPGS 2779

Query: 151  PPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWS-EPPKCLDPC- 207
            PP    +GD        Y  G+ V Y C     L GN+   C  +G W+   P C     
Sbjct: 2780 PPHSQMSGD-------SYTVGAVVRYSCIGKRTLVGNSTRMCGLDGHWTGSLPHCSGTSV 2832

Query: 208  -VISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNG 260
             V     +  + I+L  +         G ++ F C++G H  +  S R    NG
Sbjct: 2833 GVCGDPGIPAHGIRLGDSFD------PGTVMRFSCEAG-HVLRGSSERTCQANG 2879



 Score = 35.0 bits (79), Expect = 0.069
 Identities = 15/39 (38%), Positives = 25/39 (64%), Gaps = 2/39 (5%)

Query: 171 GSSVEYQCQNLYQLEGNNQITC-RNGQWS-EPPKCLDPC 207
           G +++++CQ  ++L G   ITC +N QWS + P C+  C
Sbjct: 540 GDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSC 578



 Score = 34.3 bits (77), Expect = 0.12
 Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 4/44 (9%)

Query: 168  YAPGSSVEYQCQNLYQLEGNNQITCRNGQ---WSEP-PKCLDPC 207
            +  G ++ + C   Y+LEG  +ITC  G+   WS P P+C+  C
Sbjct: 1055 FGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAEC 1098



 Score = 33.9 bits (76), Expect = 0.15
 Identities = 21/71 (29%), Positives = 31/71 (43%), Gaps = 8/71 (11%)

Query: 142  STISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQ----W 197
            S  +A  C  P    NG  +      +  G S  +QC   Y L+G+ +I+C   +    W
Sbjct: 1378 SVSTATSCNDPGIPQNGSRSG---DSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFW 1434

Query: 198  S-EPPKCLDPC 207
               PP C+ PC
Sbjct: 1435 QPSPPTCIAPC 1445



 Score = 33.5 bits (75), Expect = 0.20
 Identities = 15/41 (36%), Positives = 22/41 (53%), Gaps = 4/41 (9%)

Query: 171  GSSVEYQCQNLYQLEGNNQITCRNGQ---WSEP-PKCLDPC 207
            GSSV + C   Y L G+ ++ C +G+   W  P P C+  C
Sbjct: 1231 GSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAEC 1271



 Score = 32.7 bits (73), Expect = 0.34
 Identities = 20/78 (25%), Positives = 36/78 (46%), Gaps = 5/78 (6%)

Query: 148  KCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSE----PPKC 203
            KC PP  + N ++ +     +  G  V Y+C   + L GN  +TC+ G + +    PP C
Sbjct: 2293 KCPPPTILPNAEVVTEN-EEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPIC 2351

Query: 204  LDPCVISQEIMEKYNIKL 221
               C  ++ + +   + L
Sbjct: 2352 EVHCPTNELLTDSTGVIL 2369



 Score = 31.2 bits (69), Expect = 1.00
 Identities = 21/69 (30%), Positives = 33/69 (47%), Gaps = 9/69 (13%)

Query: 145  SAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC-----RNGQWS- 198
            SA +C   P    G     L S ++ G+ V ++C + Y L+G+ +I C        QW+ 
Sbjct: 1731 SATQCSSVPEPRYG---KRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNV 1787

Query: 199  EPPKCLDPC 207
              P C+ PC
Sbjct: 1788 SAPTCVVPC 1796



 Score = 30.0 bits (66), Expect = 2.2
 Identities = 11/22 (50%), Positives = 16/22 (72%)

Query: 171 GSSVEYQCQNLYQLEGNNQITC 192
           GSSV++ C   Y L+G+ +ITC
Sbjct: 362 GSSVQFTCNEGYDLQGSKRITC 383



 Score = 29.6 bits (65), Expect = 2.9
 Identities = 20/66 (30%), Positives = 27/66 (40%), Gaps = 9/66 (13%)

Query: 144 ISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQ-----WS 198
           + +  CG P  + NG       S +  G  V Y C   + LEG+  +TC  G      W 
Sbjct: 134 LPSHTCGNPGRLPNGIQQG---STFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWD 190

Query: 199 EP-PKC 203
            P P C
Sbjct: 191 FPLPSC 196



 Score = 28.9 bits (63), Expect = 4.9
 Identities = 24/93 (25%), Positives = 41/93 (44%), Gaps = 13/93 (13%)

Query: 107  GDTVQIICNTGYRLQNNENNISCV---ERGWSTP-PKCRSTISAEKCG-------PPPPI 155
            GDT+   C  GYRL+     I+C+    R WS+P P+C +       G       P  P+
Sbjct: 1058 GDTLTFSCFPGYRLEGTA-RITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPV 1116

Query: 156  DNGDITSFLLSVYA-PGSSVEYQCQNLYQLEGN 187
            +  +    + S+   PG  ++ + +     EG+
Sbjct: 1117 NYNNNHECIYSIQTQPGKGIQLKARAFELSEGD 1149



 Score = 28.9 bits (63), Expect = 4.9
 Identities = 19/57 (33%), Positives = 27/57 (47%), Gaps = 6/57 (10%)

Query: 100  SGQTHLEGDTVQIICNTGYRLQNNENNISCVERG----WS-TPPKCRSTISAEKCGP 151
            SG +   GD+    C+ GY LQ +   ISCV+      W  +PP C +    +  GP
Sbjct: 1397 SGDSWEAGDSTVFQCDPGYALQGSA-EISCVKIENRFFWQPSPPTCIAPCGGDLTGP 1452



 Score = 28.1 bits (61), Expect = 8.4
 Identities = 26/105 (24%), Positives = 44/105 (41%), Gaps = 17/105 (16%)

Query: 107 GDTVQIICNTGYRLQNNENNISCVE-----RGWST-PPKCRSTI-SAEKCGP-------- 151
           G +VQ  CN GY LQ ++  I+C++       WS   P CR+ +  A   GP        
Sbjct: 362 GSSVQFTCNEGYDLQGSK-RITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPN 420

Query: 152 -PPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNG 195
            P   DN     ++++   P   ++   +      G + +T  +G
Sbjct: 421 FPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERGYDTLTVGDG 465


>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
          Length = 3667

 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 44/161 (27%), Positives = 63/161 (39%), Gaps = 19/161 (11%)

Query: 53   YSCEYNFVSPSKSFWTRITCAEEGWS-PTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQ 111
            Y C   F     S   RI   +  WS   P C+ +         +  +SG      D V 
Sbjct: 2801 YQCNPGFRLIGSS--VRICQQDHNWSGQLPSCVPVSCGHPGSPIYGRTSGNGFNFNDVVT 2858

Query: 112  IICNTGYRLQNNENNISCVERGWSTPPKCRSTISAEKCGPP------PPIDNGDITSFLL 165
              CN GY +Q          R WS PP     ++    G P        I++G+ T    
Sbjct: 2859 FSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPANSKRESKIEHGNFTY--- 2915

Query: 166  SVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWSEP-PKCL 204
                 G+ V Y C   Y L G++ + C+ NGQW +P P+C+
Sbjct: 2916 -----GTVVFYDCNPGYFLFGSSVLICQPNGQWDKPLPECI 2951



 Score = 48.1 bits (113), Expect = 8e-06
 Identities = 54/192 (28%), Positives = 71/192 (36%), Gaps = 29/192 (15%)

Query: 23   CDFPKINHGILYDEEKYKPFSQVPTGEVFYYSC--EYNFVSPSKSFWTRITCAEEG-WSP 79
            C  P +    +   EKY        G   +YSC  + + +  S       TC   G WS 
Sbjct: 2955 CGHPGVPPNAVLSGEKYT------FGSTVHYSCTGKRSLLGQSSR-----TCQLNGHWSG 3003

Query: 80   T-PKC----LRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGW 134
            + P C       C  P    GH            TV+  C+TGY L  +E         W
Sbjct: 3004 SQPHCSGDATGTCGDPGTP-GHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSW 3062

Query: 135  S-TPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITC- 192
            +   P+C+    A +CG P    NG +  F +      SSV Y C   Y L G +   C 
Sbjct: 3063 TGRQPECK----AVQCGNPGTTANGKV--FRIDGTTFSSSVIYSCMEGYILSGPSVRQCT 3116

Query: 193  RNGQWSEP-PKC 203
             NG WS   P C
Sbjct: 3117 ANGTWSGTLPNC 3128



 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 55/208 (26%), Positives = 85/208 (40%), Gaps = 26/208 (12%)

Query: 48   GEVFYYSCEYNFVSPSKSFWTRITCAEEG-WS---PTPKCLRLCFFPFVENGHSESSGQT 103
            G+   Y C+  +         R TC   G WS   PT + +     P + NG  E  G  
Sbjct: 3152 GQNVSYMCQPGYTMELNGSRIR-TCTINGTWSGVMPTCRAVTCPTPPQISNGRLE--GTN 3208

Query: 104  HLEGDTVQIICNTGYRLQNNENNISCVERG-WSTP-PKCRSTISAEKCGPP--PPIDNGD 159
               G ++  IC+ GY L +    ++CV  G WS   P+C        CG P  P     +
Sbjct: 3209 FDWGFSISYICSPGYEL-SFPAVLTCVGNGTWSGEVPQCLPKF----CGDPGIPAQGKRE 3263

Query: 160  ITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWS-EPPKCLDPCVISQEIMEKY 217
              SF+       S V + C   + L G++   C+ +G WS   P C++P   +Q   E  
Sbjct: 3264 GKSFIYQ-----SEVSFSCNFPFILVGSSTRICQADGTWSGSSPHCIEP---TQTSCENP 3315

Query: 218  NIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
             +    +       + G +V+F CK G+
Sbjct: 3316 GVPRHGSQNNTFGFQVGSVVQFHCKKGH 3343



 Score = 42.0 bits (97), Expect = 6e-04
 Identities = 54/215 (25%), Positives = 83/215 (38%), Gaps = 32/215 (14%)

Query: 43   SQVPTGEVFYYSCEYNFVSPSKSFWTRITCAEEG-WSPTP-KCLR-LCFFP-FVENGHSE 98
            +Q   G    ++C+  F+    +      C   G WS +  +CL   C  P  + NG  +
Sbjct: 2733 TQTSYGSTAIFTCDLGFMLVGSAVRE---CLSSGLWSESETRCLAGHCGIPELIVNG--Q 2787

Query: 99   SSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTISAEKCGPPPPIDN 157
              G+ +   DTV   CN G+RL  +   I   +  WS   P C        CG P     
Sbjct: 2788 VIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDHNWSGQLPSCVPV----SCGHPGSPIY 2843

Query: 158  GDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCR-NGQWSEPP------KCLDPCVIS 210
            G  +    + +     V + C   Y ++G  +  C+ N QWS PP       C DP + +
Sbjct: 2844 GRTSG---NGFNFNDVVTFSCNIGYLMQGPTKAQCQANRQWSHPPPMCKVVNCSDPGIPA 2900

Query: 211  QEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGY 245
                 K   K++  N        G +V + C  GY
Sbjct: 2901 N---SKRESKIEHGN-----FTYGTVVFYDCNPGY 2927



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 22/63 (34%), Positives = 31/63 (49%), Gaps = 5/63 (7%)

Query: 149  CGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSE----PPKCL 204
            C PPPP+ N +I +     +  G  + YQC   + L GN  +TCR G+  +    PP C 
Sbjct: 2355 CQPPPPVPNAEILTED-DEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQ 2413

Query: 205  DPC 207
              C
Sbjct: 2414 VLC 2416



 Score = 38.5 bits (88), Expect = 0.006
 Identities = 38/146 (26%), Positives = 60/146 (41%), Gaps = 10/146 (6%)

Query: 65   SFWTRITCAEEG-WS-PTPKCL-RLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQ 121
            SF   +TC   G WS   P+CL + C  P +     +  G++ +    V   CN  + L 
Sbjct: 3226 SFPAVLTCVGNGTWSGEVPQCLPKFCGDPGIP-AQGKREGKSFIYQSEVSFSCNFPFILV 3284

Query: 122  NNENNISCVERGWS-TPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN 180
             +   I   +  WS + P C          P  P       +F   V   GS V++ C+ 
Sbjct: 3285 GSSTRICQADGTWSGSSPHCIEPTQTSCENPGVPRHGSQNNTFGFQV---GSVVQFHCKK 3341

Query: 181  LYQLEGNNQITC-RNGQWSE-PPKCL 204
             + L+G+   TC  +  WS   P+C+
Sbjct: 3342 GHLLQGSTTRTCLPDLTWSGIQPECI 3367



 Score = 37.0 bits (84), Expect = 0.018
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 5/43 (11%)

Query: 170  PGSSVEYQCQNLYQLEGNNQITCRNGQ----WS-EPPKCLDPC 207
            PG +V +QC   Y+L+G  +ITC   +    W   PP C+ PC
Sbjct: 1506 PGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1548



 Score = 36.2 bits (82), Expect = 0.031
 Identities = 18/44 (40%), Positives = 24/44 (54%), Gaps = 4/44 (9%)

Query: 168  YAPGSSVEYQCQNLYQLEGNNQITCRNG---QWSEP-PKCLDPC 207
            Y  G  V +QC   Y L+G++ ITC  G   +W+ P P CL  C
Sbjct: 2028 YMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQC 2071



 Score = 35.8 bits (81), Expect = 0.040
 Identities = 28/99 (28%), Positives = 44/99 (44%), Gaps = 12/99 (12%)

Query: 142  STISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNG---QWS 198
            S  + E C  P     G    F   +   G ++ + C + Y+LEG ++I C  G    WS
Sbjct: 1135 SEYNLEPCEDPGIPQYGSRIGFNFGI---GDTLTFSCSSGYRLEGTSEIICLGGGRRVWS 1191

Query: 199  EP-PKCLDPCVIS----QEIMEKYNIKLKWTNQQK-LYS 231
             P P+C+  C  S    + I+   N  L + N  + +YS
Sbjct: 1192 APLPRCVAECGASATNNEGILLSPNYPLNYENNHECIYS 1230



 Score = 35.8 bits (81), Expect = 0.040
 Identities = 19/65 (29%), Positives = 32/65 (49%), Gaps = 7/65 (10%)

Query: 147  EKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNG---QWSEP-PK 202
            + C  P P  NG +     + +  G ++ ++C   Y L GN+ +TC +G    W+ P P+
Sbjct: 2182 QSCPDPRPFRNGFVIG---NDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPR 2238

Query: 203  CLDPC 207
            C   C
Sbjct: 2239 CEALC 2243



 Score = 34.3 bits (77), Expect = 0.12
 Identities = 24/67 (35%), Positives = 29/67 (43%), Gaps = 9/67 (13%)

Query: 147  EKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEP------ 200
            E C  P  I NG   + L   Y  GS+V Y C   Y L+G + +TC  G    P      
Sbjct: 1659 ESCFDPGNIMNG---TRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGWNRAL 1715

Query: 201  PKCLDPC 207
            P C  PC
Sbjct: 1716 PSCHAPC 1722



 Score = 33.5 bits (75), Expect = 0.20
 Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 17/80 (21%)

Query: 101  GQTHLEGDTVQIICNTGYRLQNNENNISC---VERGWSTP-PKCRSTISAEKCGPPPPID 156
            G     G T+   C  GY L  N + ++C   V R W+ P P+C +      CG      
Sbjct: 2197 GNDFTVGQTISFECFPGYTLIGN-SALTCLHGVSRNWNHPLPRCEAL-----CG------ 2244

Query: 157  NGDITSFLLSVYAPGSSVEY 176
             G+IT+   ++Y+PG   EY
Sbjct: 2245 -GNITAMNGTIYSPGYPDEY 2263



 Score = 33.1 bits (74), Expect = 0.26
 Identities = 18/57 (31%), Positives = 24/57 (42%), Gaps = 1/57 (1%)

Query: 96   HSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTP-PKCRSTISAEKCGP 151
            H    G     G TV   C++GYRL + E  +      WS P P C +    +  GP
Sbjct: 978  HGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGP 1034



 Score = 31.6 bits (70), Expect = 0.76
 Identities = 50/209 (23%), Positives = 74/209 (35%), Gaps = 40/209 (19%)

Query: 61   SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSG----------QTHLEGDTV 110
            S S   W       EG   T +  +L +  F E  H E  G          Q H  G T+
Sbjct: 1282 STSNQLWLEFNSDTEG---TDEGFQLVYTSF-ELSHCEDPGIPQFGYKISDQGHFAGSTI 1337

Query: 111  QIICNTGYRLQNNENNISCV---ERGWSTP-----PKCRSTISAEKCGP------PPPID 156
               CN GY L +  + + C+    R W  P      +C      E  G       P P D
Sbjct: 1338 IYGCNPGYTL-HGSSLLKCMTGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYD 1396

Query: 157  NGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPP------KCLDPCVIS 210
            N     +++ V  PG+ V  Q    +  E ++ I      W  PP      K +   +I 
Sbjct: 1397 NNLRCMWMIEV-DPGNIVSLQFL-AFDTEASHDIL---RVWDGPPENDMLLKEISGSLIP 1451

Query: 211  QEIMEKYNIKLKWTNQQKLYSRTGDIVEF 239
            + I    NI     +     S++G  ++F
Sbjct: 1452 EGIHSTLNIVTIQFDTDFYISKSGFAIQF 1480



 Score = 31.6 bits (70), Expect = 0.76
 Identities = 47/175 (26%), Positives = 64/175 (36%), Gaps = 32/175 (18%)

Query: 50   VFYYSCEYNF--VSPSKSFWTRITCAEEGW-SPTPKCLRL-CFFPFVE-NGHSESSGQTH 104
            V  ++C+  F  V  S +   + +     W +P P C  + C  P    NG   ++   +
Sbjct: 2551 VVRWACDRGFRLVGKSSAVCRKSSYGYHAWDAPVPACQAISCGIPKAPTNGGILTTD--Y 2608

Query: 105  LEGDTVQIICNTGYRLQNNE-NNISCVERG-WSTPPKCRSTISAEKCGPPPPIDNGDITS 162
            L G  V   CN GYRL + E     C   G WS   K    +          +    I S
Sbjct: 2609 LVGTRVTYFCNDGYRLSSKELTTAVCQSDGTWSNHNKTPRCV---------VVTCPSINS 2659

Query: 163  FLL----------SVYAPGSSVEYQCQNLYQLEGNNQITC-RNGQWS---EPPKC 203
            F+L          S Y   + V + C   Y   G   I C  NG WS   E P C
Sbjct: 2660 FILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGLGPASIECLPNGTWSWRNERPYC 2714



 Score = 31.2 bits (69), Expect = 1.00
 Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 6/46 (13%)

Query: 168  YAPGSSVEYQCQNLYQLEGNNQITCRN-----GQWSEP-PKCLDPC 207
            +A GSSV + C   Y L G+  I C        QW++  P C+ PC
Sbjct: 1854 FAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPTCIVPC 1899



 Score = 30.8 bits (68), Expect = 1.3
 Identities = 20/60 (33%), Positives = 30/60 (50%), Gaps = 10/60 (16%)

Query: 107  GDTVQIICNTGYRLQNNENNISCV---ERGWSTP-PKCRSTISAEKCGPPPPIDNGDITS 162
            GDT+   C++GYRL+   + I C+    R WS P P+C       +CG     + G + S
Sbjct: 1161 GDTLTFSCSSGYRLEGT-SEIICLGGGRRVWSAPLPRC-----VAECGASATNNEGILLS 1214



 Score = 29.3 bits (64), Expect = 3.8
 Identities = 21/80 (26%), Positives = 36/80 (45%), Gaps = 13/80 (16%)

Query: 117 GYRL---QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSS 173
           G++L   ++N N  S +  G           ++  C  P   +NG       S ++ GS+
Sbjct: 418 GFKLFPGKDNSNKFSILNEGGIKT-------ASNLCPDPGEPENGKRIG---SDFSLGST 467

Query: 174 VEYQCQNLYQLEGNNQITCR 193
           V++ C   Y L+G   ITC+
Sbjct: 468 VQFSCDEDYVLQGAKSITCQ 487



 Score = 29.3 bits (64), Expect = 3.8
 Identities = 23/76 (30%), Positives = 37/76 (48%), Gaps = 14/76 (18%)

Query: 101  GQTHLEGDTVQIICNTGYRLQNNENNISCVE---RGWSTP-PKCRSTISAEKCGPPPPID 156
            G  ++ GD V   C+ GY LQ + ++I+C+    R W+ P P C +     +CG      
Sbjct: 2025 GDRYMVGDVVSFQCDQGYSLQGH-SHITCMPGPVRRWNYPIPICLA-----QCGGA---- 2074

Query: 157  NGDITSFLLSVYAPGS 172
              D +  +LS   PG+
Sbjct: 2075 MSDFSGVILSPGFPGN 2090



 Score = 28.9 bits (63), Expect = 4.9
 Identities = 27/112 (24%), Positives = 46/112 (41%), Gaps = 19/112 (16%)

Query: 168  YAPGSSVEYQCQNLYQLEGNNQITC-RNGQWSEP-PKCLDPC----------VISQEIME 215
            ++ GS+V + C + Y+L     + C +N  WS P P C   C          ++S    E
Sbjct: 986  FSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALCGGDVRGPSGTILSPGYPE 1045

Query: 216  KY--NIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVYP 265
             Y  ++   WT    +    G  V+F   + +H    H +  + +NG    P
Sbjct: 1046 FYPNSLNCTWT----VDVTHGKGVQFNFHT-FHLEDHHDYLLITENGSFTQP 1092



 Score = 28.1 bits (61), Expect = 8.4
 Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 6/46 (13%)

Query: 100  SGQTHLEGDTVQIICNTGYRLQNNENNISCVE----RGWS-TPPKC 140
            +G     GDTV   C+ GY LQ  E  I+C++      W  +PP C
Sbjct: 1500 NGDGREPGDTVVFQCDPGYELQ-GEERITCIQVENRYFWQPSPPVC 1544


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.442 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,397,359
Number of Sequences: 37866
Number of extensions: 680419
Number of successful extensions: 2022
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 1352
Number of HSP's gapped (non-prelim): 435
length of query: 270
length of database: 18,247,518
effective HSP length: 101
effective length of query: 169
effective length of database: 14,423,052
effective search space: 2437495788
effective search space used: 2437495788
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.