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Search of human proteins with 50312666
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50312666 ubiquitin specific peptidase 25 [Homo sapiens]
(1055 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50312666 ubiquitin specific peptidase 25 [Homo sapiens] 2114 0.0
gi|16507200 ubiquitin specific protease 28 [Homo sapiens] 994 0.0
gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens] 94 5e-19
gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens] 94 5e-19
gi|150378533 ubiquitin specific peptidase 7 [Homo sapiens] 64 6e-10
gi|110347427 ubiquitin specific protease 34 [Homo sapiens] 64 6e-10
gi|145309311 ubiquitin specific protease 9, X-linked isoform 4 [... 59 2e-08
gi|145309309 ubiquitin specific protease 9, X-linked isoform 3 [... 59 2e-08
gi|188497648 ubiquitin specific peptidase 37 [Homo sapiens] 59 2e-08
gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sap... 57 1e-07
gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapi... 57 1e-07
gi|71774197 ubiquitin specific protease 47 [Homo sapiens] 56 2e-07
gi|148746183 ubiquitin specific protease 35 [Homo sapiens] 55 3e-07
gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens] 54 8e-07
gi|27545313 ubiquitin specific peptidase 38 [Homo sapiens] 53 1e-06
gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens] 51 7e-06
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 50 1e-05
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 50 1e-05
gi|149192845 ubiquitin specific protease 24 [Homo sapiens] 49 3e-05
gi|32313610 ubiquitin specific protease 18 [Homo sapiens] 47 7e-05
gi|239746654 PREDICTED: ubiquitin specific protease 41 [Homo sap... 45 3e-04
gi|239757637 PREDICTED: ubiquitin specific peptidase 41 [Homo sa... 45 4e-04
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] 45 5e-04
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] 45 5e-04
gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens] 45 5e-04
gi|169215723 PREDICTED: ubiquitin specific peptidase 41 [Homo sa... 44 6e-04
gi|225579095 S-phase cyclin A-associated protein in the ER isofo... 43 0.001
gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens] 43 0.001
gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens] 43 0.001
gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens] 43 0.001
>gi|50312666 ubiquitin specific peptidase 25 [Homo sapiens]
Length = 1055
Score = 2114 bits (5477), Expect = 0.0
Identities = 1055/1055 (100%), Positives = 1055/1055 (100%)
Query: 1 MTVEQNVLQQSAAQKHQQTFLNQLREITGINDTQILQQALKDSNGNLELAVAFLTAKNAK 60
MTVEQNVLQQSAAQKHQQTFLNQLREITGINDTQILQQALKDSNGNLELAVAFLTAKNAK
Sbjct: 1 MTVEQNVLQQSAAQKHQQTFLNQLREITGINDTQILQQALKDSNGNLELAVAFLTAKNAK 60
Query: 61 TPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET 120
TPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET
Sbjct: 61 TPQQEETTYYQTALPGNDRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRET 120
Query: 121 GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWF 180
GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWF
Sbjct: 121 GITDEEQAISRVLEASIAENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWF 180
Query: 181 SAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYV 240
SAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYV
Sbjct: 181 SAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYV 240
Query: 241 DPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFY 300
DPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFY
Sbjct: 241 DPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFY 300
Query: 301 GRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQE 360
GRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQE
Sbjct: 301 GRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQE 360
Query: 361 HWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIK 420
HWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIK
Sbjct: 361 HWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIK 420
Query: 421 RLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSPPSG 480
RLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSPPSG
Sbjct: 421 RLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSPPSG 480
Query: 481 SIPSQTLPSTTEQQGALSSELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHI 540
SIPSQTLPSTTEQQGALSSELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHI
Sbjct: 481 SIPSQTLPSTTEQQGALSSELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHI 540
Query: 541 TEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHE 600
TEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHE
Sbjct: 541 TEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHE 600
Query: 601 GQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQ 660
GQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQ
Sbjct: 601 GQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQ 660
Query: 661 FLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQ 720
FLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQ
Sbjct: 661 FLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQ 720
Query: 721 KLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEETIQIITKASHEHEDKSPETVLQSA 780
KLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEETIQIITKASHEHEDKSPETVLQSA
Sbjct: 721 KLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEETIQIITKASHEHEDKSPETVLQSA 780
Query: 781 IKLEYARLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERC 840
IKLEYARLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERC
Sbjct: 781 IKLEYARLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERC 840
Query: 841 HNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMYLIIGLENFQRESYIDSLLFL 900
HNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMYLIIGLENFQRESYIDSLLFL
Sbjct: 841 HNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMYLIIGLENFQRESYIDSLLFL 900
Query: 901 ICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAELFESGEDREVNNGLIIMNE 960
ICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAELFESGEDREVNNGLIIMNE
Sbjct: 901 ICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAELFESGEDREVNNGLIIMNE 960
Query: 961 FIVPFLPLLLVDEMEEKDILAVEDMRNRWCSYLGQEMEPHLQEKLTDFLPKLLDCSMEIK 1020
FIVPFLPLLLVDEMEEKDILAVEDMRNRWCSYLGQEMEPHLQEKLTDFLPKLLDCSMEIK
Sbjct: 961 FIVPFLPLLLVDEMEEKDILAVEDMRNRWCSYLGQEMEPHLQEKLTDFLPKLLDCSMEIK 1020
Query: 1021 SFHEPPKLPSYSTHELCERFARIMLSLSRTPADGR 1055
SFHEPPKLPSYSTHELCERFARIMLSLSRTPADGR
Sbjct: 1021 SFHEPPKLPSYSTHELCERFARIMLSLSRTPADGR 1055
>gi|16507200 ubiquitin specific protease 28 [Homo sapiens]
Length = 1077
Score = 994 bits (2569), Expect = 0.0
Identities = 525/1067 (49%), Positives = 716/1067 (67%), Gaps = 57/1067 (5%)
Query: 18 QTFLNQLREITGINDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGN 77
Q LNQLREITGI D L +ALK SNG++ AV+ LT + K P Q+ + + G+
Sbjct: 22 QMLLNQLREITGIQDPSFLHEALKASNGDITQAVSLLTDERVKEPSQDTVATEPSEVEGS 81
Query: 78 DRYISVGSQADTNVIDLTGDDKDDLQRAIALSLAESNRAFRETGITDEEQAISRVLEASI 137
+ + VIDLT D+KDDLQ AIALSL ES + I + + ++R+ EA+
Sbjct: 82 ----AANKEVLAKVIDLTHDNKDDLQAAIALSLLESPK------IQADGRDLNRMHEATS 131
Query: 138 AENKACLKRTPTEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLV 197
AE K KR EVW ++ NP D +R D PVGLKNVGNTCWFSAVIQSLF L EFRRLV
Sbjct: 132 AETKRS-KRKRCEVWGENPNPNDWRRVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLV 190
Query: 198 LNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSND 257
L+Y P N + R+ E RN+ FM+EL+YLFAL++G+ RK+VDPS A+++LK AF+S++
Sbjct: 191 LSYSLPQNVLENCRSHTEKRNIMFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRSSE 250
Query: 258 SQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFENT 317
QQQDVSEFTHKLLDWLEDAFQ+ + K +NPMV+LFYG FL GV EGK F N
Sbjct: 251 EQQQDVSEFTHKLLDWLEDAFQLAVNVNSPRNKSENPMVQLFYGTFLTEGVREGKPFCNN 310
Query: 318 EMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSENSGKSGQEHWFTELPPVLTFELSRF 377
E FGQYPLQVNG+++L ECLE AM+EG++E L S++S K GQE WFT+LPPVLTFELSRF
Sbjct: 311 ETFGQYPLQVNGYRNLDECLEGAMVEGDVELLPSDHSVKYGQERWFTKLPPVLTFELSRF 370
Query: 378 EFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYL 437
EFNQ+LG+PEKIHNKLEFPQ++Y+DRYM+R++E+ R KRE I++LK+ + +LQQ+LERY+
Sbjct: 371 EFNQSLGQPEKIHNKLEFPQIIYMDRYMYRSKELIRNKRECIRKLKEEIKILQQKLERYV 430
Query: 438 SYGSGPKRFPLVDVLQYALEFASSKPVCTS--PVDDIDASSPPSG---SIPSQTLPSTTE 492
YGSGP RFPL D+L+Y +EFAS+KP S P D + P S S+ QT +T
Sbjct: 431 KYGSGPARFPLPDMLKYVIEFASTKPASESCPPESDTHMTLPLSSVHCSVSDQTSKESTS 490
Query: 493 QQGALSSELPSTSPSSVAAISSRSVIHKPFTQSRIPPDLPMHPAPRHITEEELSVLESCL 552
+ + S ++ ST S ++ KP T SR ++P PAPR +T+EE++ +++CL
Sbjct: 491 TESS-SQDVESTFSSPEDSLPKS----KPLTSSRSSMEMPSQPAPRTVTDEEINFVKTCL 545
Query: 553 HRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYI 612
RWR+EIE D +DL+ I+ +TIE MY D + QVPYRLHAVLVHEGQANAGHYWAYI
Sbjct: 546 QRWRSEIEQDIQDLKTCIASTTQTIEQMYCDPLLRQVPYRLHAVLVHEGQANAGHYWAYI 605
Query: 613 FDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQFLIQEEFNKETG 672
++ W+KYNDI+VT+SSWEE+ RDS+GG RN SAYCLMYINDK + E E+
Sbjct: 606 YNQPRQSWLKYNDISVTESSWEEVERDSYGGLRNVSAYCLMYINDKLPYFNAEAAPTESD 665
Query: 673 QPLVGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLASQKLRESETSVTTA 732
Q + +E L +L+ +++EDN RFE+E+EEW+ + + K Q + + ++ TS +
Sbjct: 666 Q-MSEVEALSVELKHYIQEDNWRFEQEVEEWEEEQSCKIPQMESSTNSSSQDYSTSQEPS 724
Query: 733 QAAGDPEYLEQPSRSDFSKHLKEETIQIITKASHEHEDKSPETVLQS------------- 779
A+ + + S+ + +KE+T Q I + +E E L
Sbjct: 725 VASS---HGVRCLSSEHAVIVKEQTAQAIANTARAYEKSGVEAALSEVMLSPAMQGVILA 781
Query: 780 -------------------AIKLEYARLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKI 820
A EY+RL +LA+E +D RL HV+VYF QN+APK++
Sbjct: 782 IAKARQTFDRDGSEAGLIKAFHEEYSRLYQLAKETPTSHSDPRLQHVLVYFFQNEAPKRV 841
Query: 821 IEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMY 880
+E+TLLEQF D+NLS+DER +IMKVAQAKL+ I P+++N+EEY++WH+DY FR+ ++Y
Sbjct: 842 VERTLLEQFADKNLSYDERSISIMKVAQAKLKEIGPDDMNMEEYKKWHEDYSLFRKVSVY 901
Query: 881 LIIGLENFQRESYIDSLLFLICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAA 940
L+ GLE +Q+ Y ++L +L+ AYQ+N LL KG RG E +I+ YRR+CLL+LN +AA
Sbjct: 902 LLTGLELYQKGKYQEALSYLVYAYQSNAALLMKGPRRGVKESVIALYRRKCLLELNAKAA 961
Query: 941 ELFESGEDREVNNGLIIMNEFIVPFLPLLLVDEMEEKDILAVEDMRNRWCSYLGQEMEPH 1000
LFE+ +D V G+ +MNE I+P + L++ +++ + D+ A+E MRN WCSYLGQ++ +
Sbjct: 962 SLFETNDDHSVTEGINVMNELIIPCIHLIINNDISKDDLDAIEVMRNHWCSYLGQDIAEN 1021
Query: 1001 LQEKLTDFLPKLLDCSMEIKSFHEPPKLPSYSTHELCERFARIMLSL 1047
LQ L +FLP+LLD S EI EPP + S ++LC RFA +M S+
Sbjct: 1022 LQLCLGEFLPRLLDPSAEIIVLKEPPTIRPNSPYDLCSRFAAVMESI 1068
>gi|76257392 ubiquitin specific protease 48 isoform b [Homo sapiens]
Length = 485
Score = 94.4 bits (233), Expect = 5e-19
Identities = 75/302 (24%), Positives = 134/302 (44%), Gaps = 33/302 (10%)
Query: 126 EQAISRVLEASIAENKACLKRTPTEVW---------RDSRNPYDRKRQDKAPVGLKNVGN 176
E I V + N CL +W + +P +R+ + VGL N+G
Sbjct: 37 EPCIRGVCRRNCKGNPNCLVGIGEHIWLGEIDENSFHNIDDPNCERRKKNSFVGLTNLGA 96
Query: 177 TCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLP-----RNQKEHRNLPFMRELRYLFAL 231
TC+ + +Q F LE R+ + Y PS D + +K++ L+YLFAL
Sbjct: 97 TCYVNTFLQVWFLNLELRQAL--YLCPSTCSDYMLGDGIQEEKDYEPQTICEHLQYLFAL 154
Query: 232 LVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKP 291
L + R+Y+DPS V+ A + QQQD EF+ + LED + +
Sbjct: 155 LQNSNRRYIDPSGFVK----ALGLDTGQQQDAQEFSKLFMSLLEDTLSKQKNPDV----- 205
Query: 292 KNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIES- 348
+N + + F G + V V G++ + F + L + G K L +C+ + E ++E
Sbjct: 206 RNIVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNIQGHKQLTDCISEFLKEEKLEGD 265
Query: 349 -----LHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 403
+ ++ + ++ LP L +L RF F++ G +K++ + F ++L ++
Sbjct: 266 NRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNTYIGFSEILDMEP 325
Query: 404 YM 405
Y+
Sbjct: 326 YV 327
Score = 48.1 bits (113), Expect = 4e-05
Identities = 37/132 (28%), Positives = 57/132 (43%), Gaps = 16/132 (12%)
Query: 591 YRLHAVLVHEG-QANAGHYWAYIFDHRESRWMKYNDIAVTKSSW--------EELVRDSF 641
Y L AVL+H G A +GHY A++ D + W K+ND + K E+L S
Sbjct: 336 YELSAVLIHRGVSAYSGHYIAHVKDPQSGEWYKFNDEDIEKMEGKKLQLGIEEDLAEPSK 395
Query: 642 GGYRNASAYCLMYINDKAQFLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKELE 701
R + + A L+ +E V + P L++ V+ DN +F E
Sbjct: 396 SQTRKPKCGKGTHCSRNAYMLVYRLQTQEKPNTTVQV---PAFLQELVDRDNSKF----E 448
Query: 702 EWDAQLAQKALQ 713
EW ++A+ Q
Sbjct: 449 EWCIEMAEMRKQ 460
>gi|52630449 ubiquitin specific protease 48 isoform a [Homo sapiens]
Length = 1035
Score = 94.4 bits (233), Expect = 5e-19
Identities = 75/302 (24%), Positives = 134/302 (44%), Gaps = 33/302 (10%)
Query: 126 EQAISRVLEASIAENKACLKRTPTEVW---------RDSRNPYDRKRQDKAPVGLKNVGN 176
E I V + N CL +W + +P +R+ + VGL N+G
Sbjct: 37 EPCIRGVCRRNCKGNPNCLVGIGEHIWLGEIDENSFHNIDDPNCERRKKNSFVGLTNLGA 96
Query: 177 TCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLP-----RNQKEHRNLPFMRELRYLFAL 231
TC+ + +Q F LE R+ + Y PS D + +K++ L+YLFAL
Sbjct: 97 TCYVNTFLQVWFLNLELRQAL--YLCPSTCSDYMLGDGIQEEKDYEPQTICEHLQYLFAL 154
Query: 232 LVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKP 291
L + R+Y+DPS V+ A + QQQD EF+ + LED + +
Sbjct: 155 LQNSNRRYIDPSGFVK----ALGLDTGQQQDAQEFSKLFMSLLEDTLSKQKNPDV----- 205
Query: 292 KNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIES- 348
+N + + F G + V V G++ + F + L + G K L +C+ + E ++E
Sbjct: 206 RNIVQQQFCGEYAYVTVCNQCGRESKLLSKFYELELNIQGHKQLTDCISEFLKEEKLEGD 265
Query: 349 -----LHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDR 403
+ ++ + ++ LP L +L RF F++ G +K++ + F ++L ++
Sbjct: 266 NRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNTYIGFSEILDMEP 325
Query: 404 YM 405
Y+
Sbjct: 326 YV 327
Score = 49.3 bits (116), Expect = 2e-05
Identities = 45/176 (25%), Positives = 72/176 (40%), Gaps = 18/176 (10%)
Query: 591 YRLHAVLVHEG-QANAGHYWAYIFDHRESRWMKYNDIAVTKSSW--------EELVRDSF 641
Y L AVL+H G A +GHY A++ D + W K+ND + K E+L S
Sbjct: 336 YELSAVLIHRGVSAYSGHYIAHVKDPQSGEWYKFNDEDIEKMEGKKLQLGIEEDLAEPSK 395
Query: 642 GGYRNASAYCLMYINDKAQFLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKELE 701
R + + A L+ +E V + P L++ V+ DN +F E
Sbjct: 396 SQTRKPKCGKGTHCSRNAYMLVYRLQTQEKPNTTVQV---PAFLQELVDRDNSKF----E 448
Query: 702 EWDAQLAQKALQEKLLASQKLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEET 757
EW ++A+ ++++ + K + E + E E S K L E T
Sbjct: 449 EWCIEMAE--MRKQSVDKGKAKHEEVKELYQRLPAGAEPYEFVSLEWLQKWLDEST 502
>gi|150378533 ubiquitin specific peptidase 7 [Homo sapiens]
Length = 1102
Score = 64.3 bits (155), Expect = 6e-10
Identities = 65/251 (25%), Positives = 117/251 (46%), Gaps = 37/251 (14%)
Query: 169 VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYL 228
VGLKN G TC+ ++++Q+LF + R+ V Y P+ D +++P + R
Sbjct: 214 VGLKNQGATCYMNSLLQTLFFTNQLRKAV--YMMPTEGDD------SSKSVPLALQ-RVF 264
Query: 229 FALL-----VGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAE 283
+ L VGTK+ + S E L D+F Q DV E LLD +E+ +
Sbjct: 265 YELQHSDKPVGTKK--LTKSFGWETL-DSF-----MQHDVQELCRVLLDNVENKMKGTCV 316
Query: 284 EETDEEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQ--VNGFKDLHECLEAAM 341
E T + +LF G+ ++ + + + Y +Q + G K++ E +
Sbjct: 317 EGT--------IPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYV 368
Query: 342 IEGEIESLHSENSGKSGQEHW-----FTELPPVLTFELSRFEFNQALGRPEKIHNKLEFP 396
+++ + ++G+ G + F LPPVL +L RF ++ + KI+++ EFP
Sbjct: 369 AVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFP 428
Query: 397 QVLYLDRYMHR 407
+ L LD ++ +
Sbjct: 429 EQLPLDEFLQK 439
Score = 59.3 bits (142), Expect = 2e-08
Identities = 37/118 (31%), Positives = 62/118 (52%), Gaps = 10/118 (8%)
Query: 591 YRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRN---- 646
Y LHAVLVH G + GHY Y+ + +W K++D V++ + EE + ++GG+ +
Sbjct: 448 YILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSV 507
Query: 647 ---ASAYCLMYIND-KAQFLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEKEL 700
+AY L+YI + K ++Q + + Q LV E L + R ++ +R E L
Sbjct: 508 RHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLV--ERLQEEKRIEAQKRKERQEAHL 563
>gi|110347427 ubiquitin specific protease 34 [Homo sapiens]
Length = 3546
Score = 64.3 bits (155), Expect = 6e-10
Identities = 68/277 (24%), Positives = 119/277 (42%), Gaps = 29/277 (10%)
Query: 158 PYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHR 217
P++ R + VGL N+G TC+ ++ IQ L+ + E R+ V K ++ +
Sbjct: 1883 PHEDVRAECRFVGLTNLGATCYLASTIQQLYMIPEARQAVFTAK----------YSEDMK 1932
Query: 218 NLPFMRELRYLFALLVGTKRKYVDPSRAVE-ILKDAFKSNDSQQQDVSEFTHKLLDWLED 276
+ + EL+ +F L+ ++ K +P + D N +Q+D++EF L+
Sbjct: 1933 HKTTLLELQKMFTYLMESECKAYNPRPFCKTYTMDKQPLNTGEQKDMTEFFTDLI----- 1987
Query: 277 AFQMKAEEETDEEKPKNPMVELFYGRFL-AVGVLEGKKFENT-EMFGQYPLQVNGFKDLH 334
K EE + E KN + LF G V L+ + T E F QV K+++
Sbjct: 1988 ---TKIEEMSPE--LKNTVKSLFGGVITNNVVSLDCEHVSQTAEEFYTVRCQVADMKNIY 2042
Query: 335 ECLEAAMIEGEIES------LHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEK 388
E L+ I+ +E H ++ + F +LP +L+F R+ FN EK
Sbjct: 2043 ESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMKEK 2102
Query: 389 IHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDY 425
++ FP L + Y ++E K + D+
Sbjct: 2103 VNTHFSFPLRLDMTPYTEDFLMGKSERKEGFKEVSDH 2139
Score = 44.3 bits (103), Expect = 6e-04
Identities = 38/136 (27%), Positives = 58/136 (42%), Gaps = 22/136 (16%)
Query: 591 YRLHAVLVHEGQANAGHYWAYIFD------HRESRWMKYNDIAVTKSSWEELVRDSFGGY 644
Y L V VH G A+ GHY+++I D ++ ++W +ND V +L + FGG
Sbjct: 2148 YDLIGVTVHTGTADGGHYYSFIRDIVNPHAYKNNKWYLFNDAEVKPFDSAQLASECFGGE 2207
Query: 645 RNASAYCLMYINDKAQFLIQEEFNKETGQPLVGIETLPPDLRDFVEEDNQRFEK-----E 699
Y + DK + F K ++ + + P EE+N R K E
Sbjct: 2208 MTTKTY--DSVTDK---FMDFSFEKTHSAYMLFYKRMEP------EEENGREYKFDVSSE 2256
Query: 700 LEEWDAQLAQKALQEK 715
L EW + LQ+K
Sbjct: 2257 LLEWIWHDNMQFLQDK 2272
>gi|145309311 ubiquitin specific protease 9, X-linked isoform 4 [Homo
sapiens]
Length = 2554
Score = 59.3 bits (142), Expect = 2e-08
Identities = 76/338 (22%), Positives = 143/338 (42%), Gaps = 61/338 (18%)
Query: 163 RQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVL-----------------------N 199
R K VGLKN G TC+ ++VIQ L+ + R +L N
Sbjct: 1551 RPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESN 1610
Query: 200 YKP-------PSNAQDLP-----RNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVE 247
P P +D P ++KE+ N+ +R L+ +F L ++ +Y P +
Sbjct: 1611 VDPRDDVFGYPQQFEDKPALSKTEDRKEY-NIGVLRHLQVIFGHLAASRLQYYVPRGFWK 1669
Query: 248 ILKDAFKS-NDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAV 306
+ + N +Q D EF + L+D L++A + + ++ G F
Sbjct: 1670 QFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAM--------LSKVLGGSFADQ 1721
Query: 307 GVLEG--KKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEI----ESLHSENSGK---S 357
+ +G ++E E F + + ++L + LE ++G++ + H E K +
Sbjct: 1722 KICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQ-YVKGDLLEGANAYHCEKCNKKVDT 1780
Query: 358 GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKRE 417
+ +LPPVL +L RF+++ K ++ EFP+ L ++ Y + + +
Sbjct: 1781 VKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPY-----TVAGVAKL 1835
Query: 418 EIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYA 455
E + ++QQ E+ S +G ++ LV VL ++
Sbjct: 1836 EGDNVNPESQLIQQS-EQSESETAGSTKYRLVGVLVHS 1872
Score = 50.1 bits (118), Expect = 1e-05
Identities = 27/61 (44%), Positives = 35/61 (57%), Gaps = 8/61 (13%)
Query: 591 YRLHAVLVHEGQANAGHYWAYIF-----DHRESRWMKYNDIAVTKSSW---EELVRDSFG 642
YRL VLVH GQA+ GHY++YI D +RW K++D VT+ EE+ FG
Sbjct: 1863 YRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFG 1922
Query: 643 G 643
G
Sbjct: 1923 G 1923
>gi|145309309 ubiquitin specific protease 9, X-linked isoform 3 [Homo
sapiens]
Length = 2570
Score = 59.3 bits (142), Expect = 2e-08
Identities = 76/338 (22%), Positives = 143/338 (42%), Gaps = 61/338 (18%)
Query: 163 RQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVL-----------------------N 199
R K VGLKN G TC+ ++VIQ L+ + R +L N
Sbjct: 1551 RPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESN 1610
Query: 200 YKP-------PSNAQDLP-----RNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVE 247
P P +D P ++KE+ N+ +R L+ +F L ++ +Y P +
Sbjct: 1611 VDPRDDVFGYPQQFEDKPALSKTEDRKEY-NIGVLRHLQVIFGHLAASRLQYYVPRGFWK 1669
Query: 248 ILKDAFKS-NDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAV 306
+ + N +Q D EF + L+D L++A + + ++ G F
Sbjct: 1670 QFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAM--------LSKVLGGSFADQ 1721
Query: 307 GVLEG--KKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEI----ESLHSENSGK---S 357
+ +G ++E E F + + ++L + LE ++G++ + H E K +
Sbjct: 1722 KICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQ-YVKGDLLEGANAYHCEKCNKKVDT 1780
Query: 358 GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKRE 417
+ +LPPVL +L RF+++ K ++ EFP+ L ++ Y + + +
Sbjct: 1781 VKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMEPY-----TVAGVAKL 1835
Query: 418 EIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYA 455
E + ++QQ E+ S +G ++ LV VL ++
Sbjct: 1836 EGDNVNPESQLIQQS-EQSESETAGSTKYRLVGVLVHS 1872
Score = 50.1 bits (118), Expect = 1e-05
Identities = 27/61 (44%), Positives = 35/61 (57%), Gaps = 8/61 (13%)
Query: 591 YRLHAVLVHEGQANAGHYWAYIF-----DHRESRWMKYNDIAVTKSSW---EELVRDSFG 642
YRL VLVH GQA+ GHY++YI D +RW K++D VT+ EE+ FG
Sbjct: 1863 YRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQCFG 1922
Query: 643 G 643
G
Sbjct: 1923 G 1923
>gi|188497648 ubiquitin specific peptidase 37 [Homo sapiens]
Length = 979
Score = 59.3 bits (142), Expect = 2e-08
Identities = 69/288 (23%), Positives = 109/288 (37%), Gaps = 46/288 (15%)
Query: 152 WRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPR 211
W R P +Q + G N+GNTC+ +A++QSLF+L F A DL +
Sbjct: 325 WNKPRVPLSSHQQQQLQ-GFSNLGNTCYMNAILQSLFSLQSF------------ANDLLK 371
Query: 212 NQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILK--------DAFKSNDSQQQDV 263
+ +P +R LLV K+ + ++LK A + + Q D
Sbjct: 372 QGIPWKKIPLNALIRRFAHLLV--KKDICNSETKKDLLKKVKNAISATAERFSGYMQNDA 429
Query: 264 SEFTHKLLDWL-EDAFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFE------- 315
EF + LD L ED ++ +T+ + ++ R V+ +FE
Sbjct: 430 HEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSPDISATRAYTCPVITNLEFEVQHSIIC 489
Query: 316 --------NTEMFGQYPLQVNGFK------DLHECLEAAMIEGEIESLHSENSGKSG-QE 360
E F + + K + + L+ E+E + GK
Sbjct: 490 KACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVR 549
Query: 361 HWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRN 408
H F LP VL L R+ FN AL KI ++ P+ L L + N
Sbjct: 550 HKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTEN 597
Score = 41.6 bits (96), Expect = 0.004
Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 7/92 (7%)
Query: 591 YRLHAVLVHEGQ-ANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASA 649
YRL +V+ H G +++GHY + ++D ++ W YND+ V+K + D R+ S
Sbjct: 889 YRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSD-----RDRSG 943
Query: 650 YCLMYINDKA-QFLIQEEFNKETGQPLVGIET 680
Y Y++ + L++ E N ++ VG T
Sbjct: 944 YIFFYMHKEIFDELLETEKNSQSLSTEVGKTT 975
>gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo
sapiens]
Length = 359
Score = 56.6 bits (135), Expect = 1e-07
Identities = 80/316 (25%), Positives = 126/316 (39%), Gaps = 64/316 (20%)
Query: 170 GLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLF 229
GL N GNTC+ ++V+Q+L+ FR VL YK QK+ NL + L LF
Sbjct: 29 GLVNFGNTCYCNSVLQALYFCRPFRENVLAYK---------AQQKKKENL--LTCLADLF 77
Query: 230 ALLVGTKRK--YVDPSRAVEILKDAFKSND----SQQQDVSEFTHKLLDWLEDAFQMKAE 283
+ K+K + P + + L+ K ND QQD EF + LL+ + D Q + +
Sbjct: 78 HSIATQKKKVGVIPPKKFISRLR---KENDLFDNYMQQDAHEFLNYLLNTIADILQEEKK 134
Query: 284 EETDEEKPKNPMV---------ELFYGRFLAVGVLEGKK--------FENTEMFGQYPLQ 326
+E K KN + EL + + G L + E F +
Sbjct: 135 QEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVD 194
Query: 327 VNGFKDLHECLEAAMIEGEIESLHSEN--------SGKSGQEHW-FTELPPVLTFELSRF 377
V + CL E+L SE S + Q+ +LP +L L RF
Sbjct: 195 VEQNTSITHCLRDF---SNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRF 251
Query: 378 EFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYL 437
++ + L R K+ ++ FP L L T + R+ D + V+ +
Sbjct: 252 KYMEQLHRYTKLSYRVVFPLELRLFN--------TSSDAVNLDRMYDLVAVV-------V 296
Query: 438 SYGSGPKRFPLVDVLQ 453
GSGP R + +++
Sbjct: 297 HCGSGPNRGHYITIVK 312
>gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo
sapiens]
Length = 366
Score = 56.6 bits (135), Expect = 1e-07
Identities = 80/316 (25%), Positives = 126/316 (39%), Gaps = 64/316 (20%)
Query: 170 GLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLF 229
GL N GNTC+ ++V+Q+L+ FR VL YK QK+ NL + L LF
Sbjct: 36 GLVNFGNTCYCNSVLQALYFCRPFRENVLAYK---------AQQKKKENL--LTCLADLF 84
Query: 230 ALLVGTKRK--YVDPSRAVEILKDAFKSND----SQQQDVSEFTHKLLDWLEDAFQMKAE 283
+ K+K + P + + L+ K ND QQD EF + LL+ + D Q + +
Sbjct: 85 HSIATQKKKVGVIPPKKFISRLR---KENDLFDNYMQQDAHEFLNYLLNTIADILQEEKK 141
Query: 284 EETDEEKPKNPMV---------ELFYGRFLAVGVLEGKK--------FENTEMFGQYPLQ 326
+E K KN + EL + + G L + E F +
Sbjct: 142 QEKQNGKLKNGNMNEPAENNKPELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVD 201
Query: 327 VNGFKDLHECLEAAMIEGEIESLHSEN--------SGKSGQEHW-FTELPPVLTFELSRF 377
V + CL E+L SE S + Q+ +LP +L L RF
Sbjct: 202 VEQNTSITHCLRDF---SNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRF 258
Query: 378 EFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYL 437
++ + L R K+ ++ FP L L T + R+ D + V+ +
Sbjct: 259 KYMEQLHRYTKLSYRVVFPLELRLFN--------TSSDAVNLDRMYDLVAVV-------V 303
Query: 438 SYGSGPKRFPLVDVLQ 453
GSGP R + +++
Sbjct: 304 HCGSGPNRGHYITIVK 319
>gi|71774197 ubiquitin specific protease 47 [Homo sapiens]
Length = 1287
Score = 56.2 bits (134), Expect = 2e-07
Identities = 61/302 (20%), Positives = 124/302 (41%), Gaps = 39/302 (12%)
Query: 591 YRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAY 650
Y L +V+VH G A GHY+A I + +W +ND V++ + E++ + G + Y
Sbjct: 399 YELFSVMVHSGSAAGGHYYACIKSFSDEQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYY 458
Query: 651 CLMYIND-KAQFLIQEEFNKETGQPLVGIETLPPDLRDFVE-----EDNQRFEKELEEWD 704
+ + A LI + + ++ P +++ V+ E+ ++ ++E+E
Sbjct: 459 SSAFASSTNAYMLIYRLKDPARNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNT 518
Query: 705 AQL-------AQKALQEKLLASQKLRESETSVTTAQAAGDPEYLEQPSRSDFSKHLKEET 757
++ ++ + E L K + + +V A D LE+ D + +K +
Sbjct: 519 CKIKLFCLHPTKQVMMENKLEVHKDKTLKEAVEMAYKMMD---LEEVIPLDCCRLVKYDE 575
Query: 758 IQIITKASHEHEDKSPETVLQSAIK--------LEYARLVKLAQEDTPPETDYRLHHVVV 809
+ S+E E+ +P +L +K LE + ++ Q P E ++H V +
Sbjct: 576 FHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQVFQSYKPGEVMVKVHVVDL 635
Query: 810 YFIQNQAP--------------KKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIK 855
AP K++I K + + ERC+N +++ + +K
Sbjct: 636 KAESVAAPITVRAYLNQTVTEFKQLISKAIHLPAETMRIVL-ERCYNDLRLLSVSSKTLK 694
Query: 856 PE 857
E
Sbjct: 695 AE 696
Score = 55.1 bits (131), Expect = 3e-07
Identities = 54/249 (21%), Positives = 113/249 (45%), Gaps = 27/249 (10%)
Query: 169 VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYL 228
VGL N TC+ ++++Q+LF EFR + ++ + +D ++P+ +L+ L
Sbjct: 100 VGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEESEED------PVTSIPY--QLQRL 151
Query: 229 FALLVGTKRKYVDPSRAVEILKDAFKSNDS-QQQDVSEFTHKLLDWLEDAFQMKAEEETD 287
F LL +K++ ++ + + S+++ QQ DV E + D LE ++ + +
Sbjct: 152 FVLLQTSKKRAIETTDVTRSF--GWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLI 209
Query: 288 EEKPKNPMVELFYGRFLAVGVLEGKKFEN-------TEMFGQYPLQVNGFKDLHECLEAA 340
E + + + Y R L G EG + + +G + + LH ++
Sbjct: 210 NELYQGKLKD--YVRCLECG-YEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPE 266
Query: 341 MIEGE----IESLHSENSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFP 396
+++G E + + G F P +LT +L RF+F+ K+++++ FP
Sbjct: 267 ILDGPNQYFCERCKKKCDARKGLR--FLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMTFP 324
Query: 397 QVLYLDRYM 405
+ L + ++
Sbjct: 325 EELDMSTFI 333
>gi|148746183 ubiquitin specific protease 35 [Homo sapiens]
Length = 1018
Score = 55.5 bits (132), Expect = 3e-07
Identities = 45/191 (23%), Positives = 82/191 (42%), Gaps = 27/191 (14%)
Query: 117 FRETGITDEEQAISRVLEASIAENKACLKRT-PTEVWRDSRN------PYDRKRQDKAPV 169
FR G D + + ++ N+ +K+ + W ++ P + D +
Sbjct: 382 FRFPGFPDLYEPVMEAIKDLHVPNEDRIKQLLGQDAWTSQKSELAGFYPRLMAKSDTGKI 441
Query: 170 GLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLF 229
GL N+GNTC+ ++++Q+LF +FR VL E+ + P M +L++LF
Sbjct: 442 GLINLGNTCYVNSILQALFMASDFRHCVLRL-------------TENNSQPLMTKLQWLF 488
Query: 230 ALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQ------MKAE 283
L ++R + P + + S QQD SE+ LLD L + + K +
Sbjct: 489 GFLEHSQRPAISPENFLSASWTPWFS-PGTQQDCSEYLKYLLDRLHEEEKTGTRICQKLK 547
Query: 284 EETDEEKPKNP 294
+ + P+ P
Sbjct: 548 QSSSPSPPEEP 558
Score = 37.0 bits (84), Expect = 0.098
Identities = 36/129 (27%), Positives = 57/129 (44%), Gaps = 23/129 (17%)
Query: 591 YRLHAVLVHEG-QANAGHYWAYIFD---------------HRESRWMKYNDIAVTKSSWE 634
Y L +V+VH G + +GHY+ Y + E++W +ND V+ SS+E
Sbjct: 845 YDLCSVVVHSGVSSESGHYYCYAREGAARPAASLGTADRPEPENQWYLFNDTRVSFSSFE 904
Query: 635 ELVRDSFGGYRNASAYCLMYINDKAQFLIQEEFNKETGQPLVGIE-TLPPDLRDFVEEDN 693
V + + +AY L Y +E E G V E TL DL + + +DN
Sbjct: 905 S-VSNVTSFFPKDTAYVLFYRQRP-----REGPEAELGSSRVRTEPTLHKDLMEAISKDN 958
Query: 694 QRFEKELEE 702
+ +E E+
Sbjct: 959 ILYLQEQEK 967
>gi|74319833 ubiquitin specific protease 9, Y-linked [Homo sapiens]
Length = 2555
Score = 53.9 bits (128), Expect = 8e-07
Identities = 74/338 (21%), Positives = 142/338 (42%), Gaps = 61/338 (18%)
Query: 163 RQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVL-----------------------N 199
R K VGLKN G TC+ ++VIQ L+ + R +L N
Sbjct: 1553 RPPKGFVGLKNAGATCYMNSVIQQLYMIPSIRNSILAIEGTGSDLHDDMFGDEKQDSESN 1612
Query: 200 YKP-------PSNAQDLP-----RNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVE 247
P P +D P ++KE+ N+ +R L+ +F L ++ +Y P +
Sbjct: 1613 VDPRDDVFGYPHQFEDKPALSKTEDRKEY-NIGVLRHLQVIFGHLAASQLQYYVPRGFWK 1671
Query: 248 ILKDAFKS-NDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAV 306
+ + N +Q D EF + L+D L++A + + ++ G F
Sbjct: 1672 QFRLWGEPVNLREQHDALEFFNSLVDSLDEALKALGHPAI--------LSKVLGGSFADQ 1723
Query: 307 GVLEG--KKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEI----ESLHSENSGK---S 357
+ +G ++E E F + + ++L + LE I+G++ + H E K +
Sbjct: 1724 KICQGCPHRYECEESFTTLNVDIRNHQNLLDSLEQ-YIKGDLLEGANAYHCEKCDKKVDT 1782
Query: 358 GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKRE 417
+ +LP VL +L RF+++ K ++ EFP+ L + Y + ++R+
Sbjct: 1783 VKRLLIKKLPRVLAIQLKRFDYDWERECAIKFNDYFEFPRELDMGPYTVAG--VANLERD 1840
Query: 418 EIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYA 455
+ + L ++ E+ + +G ++ LV VL ++
Sbjct: 1841 NVNSENE----LIEQKEQSDNETAGGTKYRLVGVLVHS 1874
Score = 48.1 bits (113), Expect = 4e-05
Identities = 26/61 (42%), Positives = 34/61 (55%), Gaps = 8/61 (13%)
Query: 591 YRLHAVLVHEGQANAGHYWAYIF-----DHRESRWMKYNDIAVTKSSW---EELVRDSFG 642
YRL VLVH GQA+ GHY++YI D + W K++D VT+ EE+ FG
Sbjct: 1865 YRLVGVLVHSGQASGGHYYSYIIQRNGKDDQTDHWYKFDDGDVTECKMDDDEEMKNQCFG 1924
Query: 643 G 643
G
Sbjct: 1925 G 1925
>gi|27545313 ubiquitin specific peptidase 38 [Homo sapiens]
Length = 1042
Score = 53.1 bits (126), Expect = 1e-06
Identities = 39/114 (34%), Positives = 60/114 (52%), Gaps = 14/114 (12%)
Query: 163 RQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFM 222
+ + GL N+GNTC+ ++VIQ+LF +FRR VL+ N +L M
Sbjct: 439 KSETGKTGLINLGNTCYMNSVIQALFMATDFRRQVLSL-----------NLNGCNSL--M 485
Query: 223 RELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLED 276
++L++LFA L T+R+ P E + + + S QQD SE+ LLD L +
Sbjct: 486 KKLQHLFAFLAHTQREAYAPRIFFEASRPPWFTPRS-QQDCSEYLRFLLDRLHE 538
Score = 33.1 bits (74), Expect = 1.4
Identities = 45/225 (20%), Positives = 88/225 (39%), Gaps = 56/225 (24%)
Query: 535 PAPRHITEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQ--VPYR 592
P + + ++ S W ++ D DL E++++ ++ +D++ VPY
Sbjct: 787 PLVLELPVKRITSFSSLSESWSVDV--DFTDLSENLAK---KLKPSGTDEASCTKLVPYL 841
Query: 593 LHAVLVHEG-QANAGHYWAY-------------------------------------IFD 614
L +V+VH G + +GHY++Y +F+
Sbjct: 842 LSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSEALALASSQSHLLGRDSPSAVFE 901
Query: 615 ------HRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYINDKAQFLIQEEFN 668
W +ND VT +S++ V+ + +AY L+Y + + N
Sbjct: 902 QDLENKEMSKEWFLFNDSRVTFTSFQS-VQKITSRFPKDTAYVLLYKKQHSTNGLSGN-N 959
Query: 669 KETGQPLVGIETLPPDLRDFVEEDNQRFEKELEEWDAQLAQKALQ 713
+G + G L +L D + +DN+ + L+E + +ALQ
Sbjct: 960 PTSGLWINGDPPLQKELMDAITKDNKLY---LQEQELNARARALQ 1001
>gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens]
Length = 370
Score = 50.8 bits (120), Expect = 7e-06
Identities = 68/265 (25%), Positives = 106/265 (40%), Gaps = 51/265 (19%)
Query: 170 GLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLF 229
GL N GNTC+ ++V+Q+L+ FR VL YK PR ++ + L LF
Sbjct: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYK------SQPRKKES-----LLTCLADLF 88
Query: 230 ALLVGTKRK--YVDPSRAVEILKDAFKSNDS-QQQDVSEFTHKLLDWLEDAFQMKAEEET 286
+ K+K + P + + L+ + D+ QQD EF + LL+ + D Q + ++E
Sbjct: 89 HSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEK 148
Query: 287 DEEKPKNPMV---------------ELFYG------RFLAVGVLEGKKFENTEMFGQYPL 325
+ N + E+F G R L + K E F +
Sbjct: 149 QNGRLPNGNIDNENNNSTPDPTWVDEIFQGTLTNETRCLTCETISSK----DEDFLDLSV 204
Query: 326 QVNGFKDLHECLEAAMIEGEIESLHSE-----NSGKSGQEHW----FTELPPVLTFELSR 376
V + CL E+L SE +S QE +LP +L L R
Sbjct: 205 DVEQNTSITHCLRGF---SNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKR 261
Query: 377 FEFNQALGRPEKIHNKLEFPQVLYL 401
F++ L R K+ ++ FP L L
Sbjct: 262 FKYMDQLHRYTKLSYRVVFPLELRL 286
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 50.1 bits (118), Expect = 1e-05
Identities = 62/274 (22%), Positives = 114/274 (41%), Gaps = 14/274 (5%)
Query: 689 VEEDNQRFEKELEEWDAQLAQKALQEKLLASQKLRE----SETSVTTAQAAGDPEYLEQP 744
V+E + E ELEE + + Q ++ +LA Q E +E A+ A + LE+
Sbjct: 864 VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEE- 922
Query: 745 SRSDFSKHLKEETIQIITKASHEHEDKSPETVLQSAIKLEYARLVKLAQEDTPPETDYRL 804
D ++EE + + + + ++ L+ + E KL E E +
Sbjct: 923 ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKK 982
Query: 805 HHVVVYFIQNQAPKKIIEKTLLE----QFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVN 860
+ +++Q K I EK L+E + + +E+ N+ K+ + MI E
Sbjct: 983 MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042
Query: 861 LEEYEEWHQDYRKFRETTMYLIIGLEN--FQRESYIDSLLFLICAYQNNKELLSKGLYRG 918
L++ E+ Q+ K + L++ + ++ ID L + +E L L RG
Sbjct: 1043 LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA---KKEEELQGALARG 1099
Query: 919 HDEELISHYRRECLLKLNEQAAELFESGEDREVN 952
DE L + + + +L Q AEL E E + +
Sbjct: 1100 DDETLHKNNALKVVRELQAQIAELQEDFESEKAS 1133
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 49.7 bits (117), Expect = 1e-05
Identities = 73/275 (26%), Positives = 113/275 (41%), Gaps = 51/275 (18%)
Query: 170 GLKNVGNTCWFSAVIQSLFNLLE----FRRL----VLNYKPPSNAQDLPRNQKEHRNLPF 221
GL+N+GNTC+ +A++QSL N+ + F+ L + N K R+Q ++ N+
Sbjct: 160 GLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDN-NVSL 218
Query: 222 MRELR-YLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQ- 279
+ E R L AL G++ + S + K QQQD EF LLD L Q
Sbjct: 219 VEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQG 278
Query: 280 ---------MKAEEETDEEKPK------NPMVELFYGRFLAVGV------LEGKKFE--- 315
+ E T K + +V +G L V E +KF+
Sbjct: 279 GFNGVSRSAILQENSTLSASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFDPFL 338
Query: 316 --NTEMFGQY-----PLQVNG-FKDLHECLEA-----AMIEGEIESLHS-ENSGKSGQEH 361
+ ++ Q+ Q NG L +CL + + E E+ H + KS ++
Sbjct: 339 DLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKF 398
Query: 362 WFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFP 396
W +LP VL L RF + L K+ +EFP
Sbjct: 399 WIQKLPKVLCLHLKRFHWTAYL--RNKVDTYVEFP 431
Score = 43.1 bits (100), Expect = 0.001
Identities = 27/71 (38%), Positives = 36/71 (50%), Gaps = 11/71 (15%)
Query: 591 YRLHAVLVHEGQA-NAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASA 649
Y L AV+VH G +GHY AY E RW +ND VT + E +V+ A A
Sbjct: 454 YDLAAVVVHHGSGVGSGHYTAYAT--HEGRWFHFNDSTVTLTDEETVVK--------AKA 503
Query: 650 YCLMYINDKAQ 660
Y L Y+ +A+
Sbjct: 504 YILFYVEHQAK 514
>gi|149192845 ubiquitin specific protease 24 [Homo sapiens]
Length = 2460
Score = 48.5 bits (114), Expect = 3e-05
Identities = 25/65 (38%), Positives = 36/65 (55%), Gaps = 5/65 (7%)
Query: 591 YRLHAVLVHEGQANAGHYWAYIFDHR---ESRWMKYNDIAVTKSSW--EELVRDSFGGYR 645
Y L V+VH GQA+AGHY+++I D R + +W K+ND + + E L + FGG
Sbjct: 1794 YELVGVIVHSGQAHAGHYYSFIKDRRGCGKGKWYKFNDTVIEEFDLNDETLEYECFGGEY 1853
Query: 646 NASAY 650
Y
Sbjct: 1854 RPKVY 1858
Score = 47.8 bits (112), Expect = 6e-05
Identities = 58/250 (23%), Positives = 100/250 (40%), Gaps = 25/250 (10%)
Query: 163 RQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFM 222
R VGL+N G TC+ +AV Q L+ +L+ ++ D
Sbjct: 1523 RSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDNPDDS----------VF 1572
Query: 223 RELRYLFALLVGTKRKYVDPSRAVEILKDAFKS-NDSQQQDVSEFTHKLLDWLEDAFQMK 281
+++ LF L+ +K +Y P +I K K +QQD EF L+D +++ +
Sbjct: 1573 YQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKM 1632
Query: 282 AEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAM 341
++ KN ++ + + ++E E F L V + L L+
Sbjct: 1633 GRDQIF----KNTFQGIYSDQKICKDCPH--RYEREEAFMALNLGVTSCQSLEISLDQ-F 1685
Query: 342 IEGEIESLHSENSGKSGQEHWFT-------ELPPVLTFELSRFEFNQALGRPEKIHNKLE 394
+ GE+ + + +E T LP VL L RF F+ GR K ++
Sbjct: 1686 VRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIR 1745
Query: 395 FPQVLYLDRY 404
FP +L ++ Y
Sbjct: 1746 FPWMLNMEPY 1755
>gi|32313610 ubiquitin specific protease 18 [Homo sapiens]
Length = 372
Score = 47.4 bits (111), Expect = 7e-05
Identities = 23/68 (33%), Positives = 40/68 (58%), Gaps = 4/68 (5%)
Query: 591 YRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGG---YRNA 647
Y L AV+ H G A++GHY YI + + +W +ND + SWE+ ++ ++G +
Sbjct: 302 YELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLVSWED-IQCTYGNPNYHWQE 360
Query: 648 SAYCLMYI 655
+AY L+Y+
Sbjct: 361 TAYLLVYM 368
Score = 41.6 bits (96), Expect = 0.004
Identities = 61/268 (22%), Positives = 106/268 (39%), Gaps = 33/268 (12%)
Query: 158 PYDRKRQDKAP---VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQK 214
P +R R P VGL N+G TC +++IQ ++F R++ P A +
Sbjct: 41 PRERPRAWDYPHGLVGLHNIGQTCCLNSLIQVFVMNVDFTRILKRITVPRGADE------ 94
Query: 215 EHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDA----FKSNDSQQQDVSEFTHKL 270
+ R++PF ++ L + +++K V P L+ F +D+ Q + + + +
Sbjct: 95 QRRSVPF--QMLLLLEKMQDSRQKAVRPLELAYCLQKCNVPLFVQHDAAQLYL-KLWNLI 151
Query: 271 LDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFEN--TEMFGQYPLQVN 328
D + D ++ + + K+ ++ +E + + T + +
Sbjct: 152 KDQITDVHLVERLQALYTIRVKDSLI-------CVDCAMESSRNSSMLTLPLSLFDVDSK 204
Query: 329 GFKDLHECLEAAMIEGEIES---LHSENSGK---SGQEHWFTELPPVLTFELSRFEFNQA 382
K L + L E+ S EN GK Q T LP LT L RF +
Sbjct: 205 PLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNS 264
Query: 383 LGRPEKIHNKLEFPQVLYLDRYMHRNRE 410
R KI + L FPQ L + + RE
Sbjct: 265 QTR--KICHSLYFPQSLDFSQILPMKRE 290
>gi|239746654 PREDICTED: ubiquitin specific protease 41 [Homo
sapiens]
Length = 347
Score = 45.4 bits (106), Expect = 3e-04
Identities = 18/46 (39%), Positives = 28/46 (60%)
Query: 591 YRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEEL 636
Y L AV+ H G A++GHY YI + + +W +ND + SWE++
Sbjct: 291 YELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLVSWEDI 336
Score = 44.3 bits (103), Expect = 6e-04
Identities = 59/250 (23%), Positives = 98/250 (39%), Gaps = 22/250 (8%)
Query: 169 VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYL 228
VGL N+G TC +++IQ ++F R++ P A + + R++PF ++ L
Sbjct: 44 VGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADE------QRRSVPF--QMLLL 95
Query: 229 FALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDE 288
+ +++K V P L+ + Q D ++ KL + ++D A+ E
Sbjct: 96 LEKMQDSRQKAVWPLELAYCLQ-KYNVPLFVQHDAAQLYLKLWNLIKDQI---ADVHLVE 151
Query: 289 EKPKNPMVELFYGRFLAVGVLEGKKFEN--TEMFGQYPLQVNGFKDLHECLEAAMIEGEI 346
M+ + +E + + T + + K L + L E+
Sbjct: 152 RLQALYMIRMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPREL 211
Query: 347 ES---LHSENSGK---SGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLY 400
S EN GK Q T LP LT L RF + R KI + L FPQ L
Sbjct: 212 SSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTR--KICHSLYFPQSLD 269
Query: 401 LDRYMHRNRE 410
+ + RE
Sbjct: 270 FSQILPMKRE 279
>gi|239757637 PREDICTED: ubiquitin specific peptidase 41 [Homo
sapiens]
Length = 344
Score = 45.1 bits (105), Expect = 4e-04
Identities = 18/46 (39%), Positives = 27/46 (58%)
Query: 591 YRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEEL 636
Y L AV+ H G A++GHY YI + +W +ND + SWE++
Sbjct: 268 YELFAVIAHVGMADSGHYCVYIRSAVDGKWFCFNDSNICLVSWEDI 313
Score = 43.9 bits (102), Expect = 8e-04
Identities = 59/250 (23%), Positives = 98/250 (39%), Gaps = 22/250 (8%)
Query: 169 VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYL 228
VGL N+G TC +++IQ ++F R++ P A + + R++PF ++ L
Sbjct: 21 VGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADE------QRRSVPF--QMLLL 72
Query: 229 FALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDE 288
+ +++K V P L+ + Q D ++ KL + ++D A+ E
Sbjct: 73 LEKMQDSRQKAVWPLELAYCLQ-KYNVPLFVQHDAAQLYLKLWNLIKDQI---ADVHLVE 128
Query: 289 EKPKNPMVELFYGRFLAVGVLEGKKFEN--TEMFGQYPLQVNGFKDLHECLEAAMIEGEI 346
M+ + +E + + T + + K L + L E+
Sbjct: 129 RLQALYMIRVKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPREL 188
Query: 347 ES---LHSENSGK---SGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLY 400
S EN GK Q T LP LT L RF + R KI + L FPQ L
Sbjct: 189 SSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTR--KICHSLYFPQSLD 246
Query: 401 LDRYMHRNRE 410
+ + RE
Sbjct: 247 FSQILPMKRE 256
>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
Length = 822
Score = 44.7 bits (104), Expect = 5e-04
Identities = 45/162 (27%), Positives = 63/162 (38%), Gaps = 22/162 (13%)
Query: 139 ENKACLKRTPTEVWRDSR------NPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLE 192
ENK K + E R+ + NP GL N+GNTC+F+AV+Q+L
Sbjct: 159 ENKKLEKESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPV 218
Query: 193 FRRL---------VLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPS 243
R L ++ +PP A P P + + TK+ V P
Sbjct: 219 LRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPK 278
Query: 244 RAV-EILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEE 284
++ K A + QQQD E LLD M+AEE
Sbjct: 279 ELFSQVCKKAVRFKGYQQQDSQELLRYLLD------GMRAEE 314
>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 44.7 bits (104), Expect = 5e-04
Identities = 45/162 (27%), Positives = 63/162 (38%), Gaps = 22/162 (13%)
Query: 139 ENKACLKRTPTEVWRDSR------NPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLE 192
ENK K + E R+ + NP GL N+GNTC+F+AV+Q+L
Sbjct: 160 ENKKLEKESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPV 219
Query: 193 FRRL---------VLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPS 243
R L ++ +PP A P P + + TK+ V P
Sbjct: 220 LRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPK 279
Query: 244 RAV-EILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEE 284
++ K A + QQQD E LLD M+AEE
Sbjct: 280 ELFSQVCKKAVRFKGYQQQDSQELLRYLLD------GMRAEE 315
>gi|75992941 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 44.7 bits (104), Expect = 5e-04
Identities = 45/162 (27%), Positives = 63/162 (38%), Gaps = 22/162 (13%)
Query: 139 ENKACLKRTPTEVWRDSR------NPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLE 192
ENK K + E R+ + NP GL N+GNTC+F+AV+Q+L
Sbjct: 160 ENKKLEKESKNEQEREKKENMAKENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPV 219
Query: 193 FRRL---------VLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPS 243
R L ++ +PP A P P + + TK+ V P
Sbjct: 220 LRELLKEVKMSGTIVKIEPPDLALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPK 279
Query: 244 RAV-EILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEE 284
++ K A + QQQD E LLD M+AEE
Sbjct: 280 ELFSQVCKKAVRFKGYQQQDSQELLRYLLD------GMRAEE 315
>gi|169215723 PREDICTED: ubiquitin specific peptidase 41 [Homo
sapiens]
Length = 346
Score = 44.3 bits (103), Expect = 6e-04
Identities = 59/250 (23%), Positives = 98/250 (39%), Gaps = 22/250 (8%)
Query: 169 VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYL 228
VGL N+G TC +++IQ ++F R++ P A + + R++PF ++ L
Sbjct: 44 VGLHNIGQTCCLNSLIQVFVMNVDFARILKRITVPRGADE------QRRSVPF--QMLLL 95
Query: 229 FALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDE 288
+ +++K V P L+ + Q D ++ KL + ++D A+ E
Sbjct: 96 LEKMQDSRQKAVWPLELAYCLQ-KYNVPLFVQHDAAQLYLKLWNLIKDQI---ADVHLVE 151
Query: 289 EKPKNPMVELFYGRFLAVGVLEGKKFEN--TEMFGQYPLQVNGFKDLHECLEAAMIEGEI 346
M+ + +E + + T + + K L + L E+
Sbjct: 152 RLQALYMIRMKDSLICLDCAMESSRNSSMLTLRLSFFDVDSKPLKTLEDALHCFFQPREL 211
Query: 347 ES---LHSENSGK---SGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLY 400
S EN GK Q T LP LT L RF + R KI + L FPQ L
Sbjct: 212 SSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTR--KICHSLYFPQSLD 269
Query: 401 LDRYMHRNRE 410
+ + RE
Sbjct: 270 FSQILPMKRE 279
Score = 38.5 bits (88), Expect = 0.034
Identities = 15/35 (42%), Positives = 22/35 (62%)
Query: 591 YRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYND 625
Y L AV+ H G A++GHY YI + + +W +ND
Sbjct: 291 YELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFND 325
>gi|225579095 S-phase cyclin A-associated protein in the ER isoform
b [Homo sapiens]
Length = 1154
Score = 43.1 bits (100), Expect = 0.001
Identities = 73/289 (25%), Positives = 117/289 (40%), Gaps = 37/289 (12%)
Query: 662 LIQEEFNKETGQPLVGIETL--PPDLRDFVEEDNQRFEKELEEWDAQLAQKALQEKLLAS 719
+++EE + G + E L P R E + EK+++ QL +K +EK L
Sbjct: 266 IVEEEPARPPGHGIHMHEKLSSPSRKRTIAESKKKHEEKQMKA--QQLREKLREEKTLKL 323
Query: 720 QKLRESETSVTTAQAAGDPEYLEQPSRSDFSKHL-----KEETIQIITKASHEHEDKSPE 774
QKL E E V + E L+Q R K L +E +Q I K + E E K E
Sbjct: 324 QKLLEREKDVRKWK----EELLDQRRRMMEEKLLHAEFKREVQLQAIVKKAQEEEAKVNE 379
Query: 775 TVLQSAIKLEYARLVKLAQEDTPPETDYRLHHVVVYFIQNQAPKKIIEKTLLEQFGDRNL 834
+ ++ + R L++ E + RL+ +Q + ++ EK R+
Sbjct: 380 IAFINTLEAQNKRHDVLSK---LKEYEQRLNE-----LQEERQRRQEEKQA------RDE 425
Query: 835 SFDERCHNIMKVAQAKLEMIKPEEVNLE-EYEEWHQDYRKFRETTMYLIIGLENFQRESY 893
+ ER + QA++E + + E E+ Q+ K RE +
Sbjct: 426 AVQERKRALEAERQARVEELLMKRKEQEARIEQQRQEKEKAREDA-------ARERARDR 478
Query: 894 IDSLLFLICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAEL 942
+ L L A Q E L K + HDE + H E + + E+AAEL
Sbjct: 479 EERLAALTAAQQEAMEELQKKIQLKHDESIRRH--MEQIEQRKEKAAEL 525
>gi|42516561 ubiquitin specific protease 33 isoform 3 [Homo sapiens]
Length = 828
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/100 (30%), Positives = 47/100 (47%), Gaps = 14/100 (14%)
Query: 589 VPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNAS 648
V Y L +V+ H G A++GHY AY ++ + W +++D +VT+ S + +NA
Sbjct: 647 VTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTV--------QNAE 698
Query: 649 AYCLMYINDKAQFLIQEEFNKETGQPLVGIETLPPDLRDF 688
AY L Y EE KE + + + P L F
Sbjct: 699 AYVLFYRKS------SEEAQKERRRISNLLNIMEPSLLQF 732
Score = 37.7 bits (86), Expect = 0.058
Identities = 35/129 (27%), Positives = 57/129 (44%), Gaps = 11/129 (8%)
Query: 170 GLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLF 229
GLKN+GNTC+ +A +Q+L N + L+ + P K + L M EL +
Sbjct: 186 GLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSY--LKLMTELWH-- 241
Query: 230 ALLVGTKRKYVDPSRAVEILKDAFKS-NDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDE 288
++ V P+ + +K + QQD EF L+D L + ++K + E
Sbjct: 242 ----KSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHE--ELKEQVMEVE 295
Query: 289 EKPKNPMVE 297
E P+ E
Sbjct: 296 EDPQTITTE 304
>gi|42516567 ubiquitin specific protease 33 isoform 1 [Homo sapiens]
Length = 942
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/100 (30%), Positives = 47/100 (47%), Gaps = 14/100 (14%)
Query: 589 VPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNAS 648
V Y L +V+ H G A++GHY AY ++ + W +++D +VT+ S + +NA
Sbjct: 655 VTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTV--------QNAE 706
Query: 649 AYCLMYINDKAQFLIQEEFNKETGQPLVGIETLPPDLRDF 688
AY L Y EE KE + + + P L F
Sbjct: 707 AYVLFYRKS------SEEAQKERRRISNLLNIMEPSLLQF 740
Score = 37.7 bits (86), Expect = 0.058
Identities = 35/129 (27%), Positives = 57/129 (44%), Gaps = 11/129 (8%)
Query: 170 GLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLF 229
GLKN+GNTC+ +A +Q+L N + L+ + P K + L M EL +
Sbjct: 186 GLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSY--LKLMTELWH-- 241
Query: 230 ALLVGTKRKYVDPSRAVEILKDAFKS-NDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDE 288
++ V P+ + +K + QQD EF L+D L + ++K + E
Sbjct: 242 ----KSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHE--ELKEQVMEVE 295
Query: 289 EKPKNPMVE 297
E P+ E
Sbjct: 296 EDPQTITTE 304
>gi|42516565 ubiquitin specific protease 33 isoform 2 [Homo sapiens]
Length = 911
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/100 (30%), Positives = 47/100 (47%), Gaps = 14/100 (14%)
Query: 589 VPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNAS 648
V Y L +V+ H G A++GHY AY ++ + W +++D +VT+ S + +NA
Sbjct: 624 VTYDLLSVICHHGTASSGHYIAYCRNNLNNLWYEFDDQSVTEVSESTV--------QNAE 675
Query: 649 AYCLMYINDKAQFLIQEEFNKETGQPLVGIETLPPDLRDF 688
AY L Y EE KE + + + P L F
Sbjct: 676 AYVLFYRKS------SEEAQKERRRISNLLNIMEPSLLQF 709
Score = 37.7 bits (86), Expect = 0.058
Identities = 35/129 (27%), Positives = 57/129 (44%), Gaps = 11/129 (8%)
Query: 170 GLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLF 229
GLKN+GNTC+ +A +Q+L N + L+ + P K + L M EL +
Sbjct: 155 GLKNIGNTCYMNAALQALSNCPPLTQFFLDCGGLARTDKKPAICKSY--LKLMTELWH-- 210
Query: 230 ALLVGTKRKYVDPSRAVEILKDAFKS-NDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDE 288
++ V P+ + +K + QQD EF L+D L + ++K + E
Sbjct: 211 ----KSRPGSVVPTTLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHE--ELKEQVMEVE 264
Query: 289 EKPKNPMVE 297
E P+ E
Sbjct: 265 EDPQTITTE 273
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.381
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,348,040
Number of Sequences: 37866
Number of extensions: 1874880
Number of successful extensions: 8241
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 94
Number of HSP's successfully gapped in prelim test: 129
Number of HSP's that attempted gapping in prelim test: 7669
Number of HSP's gapped (non-prelim): 692
length of query: 1055
length of database: 18,247,518
effective HSP length: 113
effective length of query: 942
effective length of database: 13,968,660
effective search space: 13158477720
effective search space used: 13158477720
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.