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Search of human proteins with 4885661
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
(543 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 1116 0.0
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 819 0.0
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 819 0.0
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 813 0.0
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 793 0.0
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 752 0.0
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 752 0.0
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 752 0.0
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 717 0.0
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 617 e-176
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 587 e-168
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 587 e-168
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 583 e-166
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 583 e-166
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 557 e-159
gi|4503787 fyn-related kinase [Homo sapiens] 464 e-131
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 379 e-105
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 369 e-102
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 369 e-102
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 368 e-102
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 368 e-102
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 368 e-102
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 368 e-102
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 367 e-101
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 348 5e-96
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 320 3e-87
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 318 1e-86
gi|148596974 TXK tyrosine kinase [Homo sapiens] 317 2e-86
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 314 1e-85
gi|187475373 c-src tyrosine kinase [Homo sapiens] 293 4e-79
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 1116 bits (2886), Expect = 0.0
Identities = 543/543 (100%), Positives = 543/543 (100%)
Query: 1 MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT 60
MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
Sbjct: 1 MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT 60
Query: 61 PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120
PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
Sbjct: 61 PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120
Query: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG 180
INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
Sbjct: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG 180
Query: 181 IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY 240
IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
Sbjct: 181 IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY 240
Query: 241 TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 300
TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
Sbjct: 241 TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 300
Query: 301 KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL 360
KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
Sbjct: 301 KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL 360
Query: 361 KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL 420
KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
Sbjct: 361 KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL 420
Query: 421 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE 480
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
Sbjct: 421 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE 480
Query: 481 VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG 540
VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
Sbjct: 481 VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG 540
Query: 541 ENL 543
ENL
Sbjct: 541 ENL 543
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 819 bits (2116), Expect = 0.0
Identities = 401/543 (73%), Positives = 450/543 (82%), Gaps = 7/543 (1%)
Query: 1 MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT 60
MG KSK + + E + A T P + +G + F+ +
Sbjct: 1 MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE 60
Query: 61 PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120
P FGG +SS +V L GGVT FVALYDYE+RT DLSFKKGER QI
Sbjct: 61 P-------KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQI 113
Query: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG 180
+NNTEGDWW A S++TG+ GYIPSNYVAP+DSIQAEEWYFGK+ R+++ERLLLN N RG
Sbjct: 114 VNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRG 173
Query: 181 IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY 240
FLVRESETTKGAY LS+ D+D +G NVKHYKIRKLD+GG+YIT+R QF++LQ+LV +Y
Sbjct: 174 TFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYY 233
Query: 241 TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 300
++HADGLCH+LTTVCPT KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
Sbjct: 234 SKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 293
Query: 301 KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL 360
+VAIKTLKPGTM PEAFLQEAQ+MKKLRH+KLV LYAVVSEEPIYIVTE+MSKGSLLDFL
Sbjct: 294 RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFL 353
Query: 361 KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL 420
K GKYL+LPQLVDMAAQIA GMAY+ERMNY+HRDLRAANILVGENLVCK+ADFGLARL
Sbjct: 354 KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413
Query: 421 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE 480
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL TEL TKGRVPYPGMVNRE
Sbjct: 414 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNRE 473
Query: 481 VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG 540
VL+QVERGYRMPCP CPESLH+LM CW+K+P+ERPTFEY+Q+FLEDYFT+TEPQYQPG
Sbjct: 474 VLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPG 533
Query: 541 ENL 543
ENL
Sbjct: 534 ENL 536
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 819 bits (2116), Expect = 0.0
Identities = 401/543 (73%), Positives = 450/543 (82%), Gaps = 7/543 (1%)
Query: 1 MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT 60
MG KSK + + E + A T P + +G + F+ +
Sbjct: 1 MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE 60
Query: 61 PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120
P FGG +SS +V L GGVT FVALYDYE+RT DLSFKKGER QI
Sbjct: 61 P-------KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQI 113
Query: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG 180
+NNTEGDWW A S++TG+ GYIPSNYVAP+DSIQAEEWYFGK+ R+++ERLLLN N RG
Sbjct: 114 VNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRG 173
Query: 181 IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY 240
FLVRESETTKGAY LS+ D+D +G NVKHYKIRKLD+GG+YIT+R QF++LQ+LV +Y
Sbjct: 174 TFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYY 233
Query: 241 TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 300
++HADGLCH+LTTVCPT KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
Sbjct: 234 SKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 293
Query: 301 KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL 360
+VAIKTLKPGTM PEAFLQEAQ+MKKLRH+KLV LYAVVSEEPIYIVTE+MSKGSLLDFL
Sbjct: 294 RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFL 353
Query: 361 KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL 420
K GKYL+LPQLVDMAAQIA GMAY+ERMNY+HRDLRAANILVGENLVCK+ADFGLARL
Sbjct: 354 KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413
Query: 421 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE 480
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL TEL TKGRVPYPGMVNRE
Sbjct: 414 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNRE 473
Query: 481 VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG 540
VL+QVERGYRMPCP CPESLH+LM CW+K+P+ERPTFEY+Q+FLEDYFT+TEPQYQPG
Sbjct: 474 VLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPG 533
Query: 541 ENL 543
ENL
Sbjct: 534 ENL 536
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 813 bits (2100), Expect = 0.0
Identities = 401/543 (73%), Positives = 448/543 (82%), Gaps = 9/543 (1%)
Query: 1 MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT 60
MGC++ K+ + A K E +S YG +PT P + + +
Sbjct: 1 MGCVQCKDKE--ATKLTEERDGSLNQSSGYRYGTDPT-----PQHYPSFGVTSIPNYNNF 53
Query: 61 PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120
G G+T FGG +SS G GVT+FVALYDYEART +DLSF KGE+FQI
Sbjct: 54 HAAGGQGLTVFGGVNSSSHTGTLRTRGGT--GVTLFVALYDYEARTEDDLSFHKGEKFQI 111
Query: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG 180
+N++EGDWWEARS+ TG+ GYIPSNYVAP DSIQAEEWYFGK+GRKDAER LL+ GN RG
Sbjct: 112 LNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRG 171
Query: 181 IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY 240
FL+RESETTKGAYSLSIRDWD+++GD+VKHYKIRKLDNGGYYITTRAQF+TLQ+LV+HY
Sbjct: 172 TFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY 231
Query: 241 TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 300
+E ADGLC LT + + PQT GLAKDAWE+ R SL LE KLGQGCF EVW+GTWNG T
Sbjct: 232 SEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNT 291
Query: 301 KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL 360
KVAIKTLKPGTM PE+FL+EAQIMKKL+HDKLV LYAVVSEEPIYIVTE+M+KGSLLDFL
Sbjct: 292 KVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFL 351
Query: 361 KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL 420
K+G+G+ LKLP LVDMAAQ+A GMAYIERMNYIHRDLR+ANILVG L+CKIADFGLARL
Sbjct: 352 KDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARL 411
Query: 421 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE 480
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL TELVTKGRVPYPGM NRE
Sbjct: 412 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNRE 471
Query: 481 VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG 540
VLEQVERGYRMPCPQ CP SLHELM CWKKDP+ERPTFEY+QSFLEDYFTATEPQYQPG
Sbjct: 472 VLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPG 531
Query: 541 ENL 543
ENL
Sbjct: 532 ENL 534
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 793 bits (2047), Expect = 0.0
Identities = 396/546 (72%), Positives = 444/546 (81%), Gaps = 12/546 (2%)
Query: 1 MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT 60
MGC++ K+ + A K E +S YG +PT P + + +
Sbjct: 1 MGCVQCKDKE--ATKLTEERDGSLNQSSGYRYGTDPT-----PQHYPSFGVTSIPNYNNF 53
Query: 61 PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120
G G+T FGG +SS G GVT+FVALYDYEART +DLSF KGE+FQI
Sbjct: 54 HAAGGQGLTVFGGVNSSSHTGTLRTRGGT--GVTLFVALYDYEARTEDDLSFHKGEKFQI 111
Query: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG 180
+N++EGDWWEARS+ TG+ GYIPSNYVAP DSIQAEEWYFGK+GRKDAER LL+ GN RG
Sbjct: 112 LNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRG 171
Query: 181 IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY 240
FL+RESETTKGAYSLSIRDWD+++GD+VKHYKIRKLDNGGYYITTRAQF+TLQ+LV+HY
Sbjct: 172 TFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY 231
Query: 241 TEHADGLCHKLTTVCPTVKPQTQGLA---KDAWEIPRESLRLEVKLGQGCFGEVWMGTWN 297
+E A GLC +L C P+ L+ KD WEIPRESL+L +LG G FGEVWMGTWN
Sbjct: 232 SERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWN 291
Query: 298 GTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLL 357
G TKVAIKTLKPGTM PE+FL+EAQIMKKL+HDKLV LYAVVSEEPIYIVTE+M+KGSLL
Sbjct: 292 GNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLL 351
Query: 358 DFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGL 417
DFLK+G+G+ LKLP LVDMAAQ+A GMAYIERMNYIHRDLR+ANILVG L+CKIADFGL
Sbjct: 352 DFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGL 411
Query: 418 ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMV 477
ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL TELVTKGRVPYPGM
Sbjct: 412 ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMN 471
Query: 478 NREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQY 537
NREVLEQVERGYRMPCPQ CP SLHELM CWKKDP+ERPTFEY+QSFLEDYFTATEPQY
Sbjct: 472 NREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQY 531
Query: 538 QPGENL 543
QPGENL
Sbjct: 532 QPGENL 537
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 752 bits (1942), Expect = 0.0
Identities = 364/515 (70%), Positives = 421/515 (81%), Gaps = 18/515 (3%)
Query: 28 SVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPA 87
+ HYG +PT P S + NFSS ++ P SG
Sbjct: 30 AADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTI-----------------R 72
Query: 88 GLTG-GVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNY 146
G++G GVT+F+ALYDYEART +DL+F KGE+F I+NNTEGDWWEARS+++GK G IPSNY
Sbjct: 73 GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNY 132
Query: 147 VAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRG 206
VAP DSIQAEEWYFGK+GRKDAER LL+PGN +G FL+RESETTKGAYSLSIRDWD+ RG
Sbjct: 133 VAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRG 192
Query: 207 DNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLA 266
D+VKHYKIRKLD GGYYITTR QF+++Q+LV+HY E DGLC+ L C +KPQT GLA
Sbjct: 193 DHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLA 252
Query: 267 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKK 326
KDAWEI R S+ LE +LG GCFG+VW+GTWNG+TKVA+KTLKPGTM P+AFL+EAQ+MK
Sbjct: 253 KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKL 312
Query: 327 LRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAY 386
LRHDKLV LYAVVSEEPIYIVTEFM GSLLDFLK +G+ L+LPQLVDMAAQ+A+GMAY
Sbjct: 313 LRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAY 372
Query: 387 IERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 446
+ERMNYIHRDLRAANILVGE L CKIADFGLARLI+D+EY QG+KFPIKWTAPEAAL+
Sbjct: 373 MERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALF 432
Query: 447 GRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMN 506
GRFTIKSDVWSFGIL TEL+TKGR+PYPGM REVLEQVE+GY MPCP GCP SL+E M
Sbjct: 433 GRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAME 492
Query: 507 LCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGE 541
W+ DP+ERPTFEY+QSFLEDYFT+ EPQYQPG+
Sbjct: 493 QTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 752 bits (1942), Expect = 0.0
Identities = 364/515 (70%), Positives = 421/515 (81%), Gaps = 18/515 (3%)
Query: 28 SVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPA 87
+ HYG +PT P S + NFSS ++ P SG
Sbjct: 30 AADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTI-----------------R 72
Query: 88 GLTG-GVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNY 146
G++G GVT+F+ALYDYEART +DL+F KGE+F I+NNTEGDWWEARS+++GK G IPSNY
Sbjct: 73 GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNY 132
Query: 147 VAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRG 206
VAP DSIQAEEWYFGK+GRKDAER LL+PGN +G FL+RESETTKGAYSLSIRDWD+ RG
Sbjct: 133 VAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRG 192
Query: 207 DNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLA 266
D+VKHYKIRKLD GGYYITTR QF+++Q+LV+HY E DGLC+ L C +KPQT GLA
Sbjct: 193 DHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLA 252
Query: 267 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKK 326
KDAWEI R S+ LE +LG GCFG+VW+GTWNG+TKVA+KTLKPGTM P+AFL+EAQ+MK
Sbjct: 253 KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKL 312
Query: 327 LRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAY 386
LRHDKLV LYAVVSEEPIYIVTEFM GSLLDFLK +G+ L+LPQLVDMAAQ+A+GMAY
Sbjct: 313 LRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAY 372
Query: 387 IERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 446
+ERMNYIHRDLRAANILVGE L CKIADFGLARLI+D+EY QG+KFPIKWTAPEAAL+
Sbjct: 373 MERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALF 432
Query: 447 GRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMN 506
GRFTIKSDVWSFGIL TEL+TKGR+PYPGM REVLEQVE+GY MPCP GCP SL+E M
Sbjct: 433 GRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAME 492
Query: 507 LCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGE 541
W+ DP+ERPTFEY+QSFLEDYFT+ EPQYQPG+
Sbjct: 493 QTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 752 bits (1942), Expect = 0.0
Identities = 364/515 (70%), Positives = 421/515 (81%), Gaps = 18/515 (3%)
Query: 28 SVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPA 87
+ HYG +PT P S + NFSS ++ P SG
Sbjct: 30 AADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTI-----------------R 72
Query: 88 GLTG-GVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNY 146
G++G GVT+F+ALYDYEART +DL+F KGE+F I+NNTEGDWWEARS+++GK G IPSNY
Sbjct: 73 GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNY 132
Query: 147 VAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRG 206
VAP DSIQAEEWYFGK+GRKDAER LL+PGN +G FL+RESETTKGAYSLSIRDWD+ RG
Sbjct: 133 VAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRG 192
Query: 207 DNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLA 266
D+VKHYKIRKLD GGYYITTR QF+++Q+LV+HY E DGLC+ L C +KPQT GLA
Sbjct: 193 DHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLA 252
Query: 267 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKK 326
KDAWEI R S+ LE +LG GCFG+VW+GTWNG+TKVA+KTLKPGTM P+AFL+EAQ+MK
Sbjct: 253 KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKL 312
Query: 327 LRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAY 386
LRHDKLV LYAVVSEEPIYIVTEFM GSLLDFLK +G+ L+LPQLVDMAAQ+A+GMAY
Sbjct: 313 LRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAY 372
Query: 387 IERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 446
+ERMNYIHRDLRAANILVGE L CKIADFGLARLI+D+EY QG+KFPIKWTAPEAAL+
Sbjct: 373 MERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALF 432
Query: 447 GRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMN 506
GRFTIKSDVWSFGIL TEL+TKGR+PYPGM REVLEQVE+GY MPCP GCP SL+E M
Sbjct: 433 GRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAME 492
Query: 507 LCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGE 541
W+ DP+ERPTFEY+QSFLEDYFT+ EPQYQPG+
Sbjct: 493 QTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 717 bits (1851), Expect = 0.0
Identities = 367/543 (67%), Positives = 410/543 (75%), Gaps = 61/543 (11%)
Query: 1 MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT 60
MGC++ K+ + A K E +S YG +PT P + + +
Sbjct: 1 MGCVQCKDKE--ATKLTEERDGSLNQSSGYRYGTDPT-----PQHYPSFGVTSIPNYNNF 53
Query: 61 PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120
G G+T FGG +SS G GVT+FVALYDYEART +DLSF KGE+FQI
Sbjct: 54 HAAGGQGLTVFGGVNSSSHTGTLRTRGGT--GVTLFVALYDYEARTEDDLSFHKGEKFQI 111
Query: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG 180
+N++EGDWWEARS+ TG+ GYIPSNYVAP DSIQAEEWYFGK+GRKDAER LL+ GN RG
Sbjct: 112 LNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRG 171
Query: 181 IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY 240
FL+RESETTKGAYSLSIRDWD+++GD+VKHYKIRKLDNGGYYITTRAQF+TLQ+LV+HY
Sbjct: 172 TFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHY 231
Query: 241 TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 300
+ GTWNG T
Sbjct: 232 S----------------------------------------------------GTWNGNT 239
Query: 301 KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL 360
KVAIKTLKPGTM PE+FL+EAQIMKKL+HDKLV LYAVVSEEPIYIVTE+M+KGSLLDFL
Sbjct: 240 KVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFL 299
Query: 361 KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL 420
K+G+G+ LKLP LVDMAAQ+A GMAYIERMNYIHRDLR+ANILVG L+CKIADFGLARL
Sbjct: 300 KDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARL 359
Query: 421 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE 480
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL TELVTKGRVPYPGM NRE
Sbjct: 360 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNRE 419
Query: 481 VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG 540
VLEQVERGYRMPCPQ CP SLHELM CWKKDP+ERPTFEY+QSFLEDYFTATEPQYQPG
Sbjct: 420 VLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPG 479
Query: 541 ENL 543
ENL
Sbjct: 480 ENL 482
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 617 bits (1590), Expect = e-176
Identities = 304/466 (65%), Positives = 367/466 (78%), Gaps = 4/466 (0%)
Query: 73 GASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEAR 132
G +S S P AG I VALYDYEA EDLSF+KG++ ++ + G+WW+AR
Sbjct: 62 GPNSHNSNTPGIREAGSED--IIVVALYDYEAIHHEDLSFQKGDQMVVLEES-GEWWKAR 118
Query: 133 SIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKG 192
S+AT K GYIPSNYVA DS++ EEW+F + RKDAER LL PGN G F++R+SETTKG
Sbjct: 119 SLATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKG 178
Query: 193 AYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLT 252
+YSLS+RD+D +GD VKHYKIR LDNGG+YI+ R+ F TLQ+LV HY + DGLC KL+
Sbjct: 179 SYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLS 238
Query: 253 TVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTM 312
C + KPQ + KDAWEIPRESL+LE KLG G FGEVWM T+N TKVA+KT+KPG+M
Sbjct: 239 VPCMSSKPQ-KPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSM 297
Query: 313 MPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQ 372
EAFL EA +MK L+HDKLV L+AVV++EPIYI+TEFM+KGSLLDFLK +G LP+
Sbjct: 298 SVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPK 357
Query: 373 LVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGA 432
L+D +AQIA+GMA+IE+ NYIHRDLRAANILV +LVCKIADFGLAR+IEDNEYTAR+GA
Sbjct: 358 LIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGA 417
Query: 433 KFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMP 492
KFPIKWTAPEA +G FTIKSDVWSFGIL E+VT GR+PYPGM N EV+ +ERGYRMP
Sbjct: 418 KFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMP 477
Query: 493 CPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQ 538
P+ CPE L+ +M CWK P+ERPTFEYIQS L+D++TATE QYQ
Sbjct: 478 RPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQ 523
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 587 bits (1513), Expect = e-168
Identities = 277/445 (62%), Positives = 355/445 (79%), Gaps = 3/445 (0%)
Query: 95 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQ 154
I VALY Y+ +DLSFKKGE+ +++ G+WW+A+S+ T K G+IPSNYVA ++++
Sbjct: 46 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 104
Query: 155 AEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKI 214
EEW+F + RKDAER LL PGN G FL+RESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 164
Query: 215 RKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPR 274
R LDNGGYYI+ R F + ++KHY + ADGLC +L C + KPQ + KDAWEIPR
Sbjct: 165 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ-KPWDKDAWEIPR 223
Query: 275 ESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVP 334
ES++L +LG G FGEVWMG +N +TKVA+KTLKPGTM +AFL+EA +MK L+HDKLV
Sbjct: 224 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 283
Query: 335 LYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYI 393
LYAVV+ EEPIYI+TE+M+KGSLLDFLK +G + LP+L+D +AQIA+GMAYIER NYI
Sbjct: 284 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 343
Query: 394 HRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 453
HRDLRAAN+LV E+L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKS
Sbjct: 344 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 403
Query: 454 DVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDP 513
DVWSFGIL E+VT G++PYPG N +V+ + +GYRMP + CP+ L+++M +CWK+
Sbjct: 404 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 463
Query: 514 DERPTFEYIQSFLEDYFTATEPQYQ 538
+ERPTF+Y+QS L+D++TATE QYQ
Sbjct: 464 EERPTFDYLQSVLDDFYTATEGQYQ 488
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 587 bits (1513), Expect = e-168
Identities = 277/445 (62%), Positives = 355/445 (79%), Gaps = 3/445 (0%)
Query: 95 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQ 154
I VALY Y+ +DLSFKKGE+ +++ G+WW+A+S+ T K G+IPSNYVA ++++
Sbjct: 67 IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125
Query: 155 AEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKI 214
EEW+F + RKDAER LL PGN G FL+RESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 185
Query: 215 RKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPR 274
R LDNGGYYI+ R F + ++KHY + ADGLC +L C + KPQ + KDAWEIPR
Sbjct: 186 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ-KPWDKDAWEIPR 244
Query: 275 ESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVP 334
ES++L +LG G FGEVWMG +N +TKVA+KTLKPGTM +AFL+EA +MK L+HDKLV
Sbjct: 245 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 304
Query: 335 LYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYI 393
LYAVV+ EEPIYI+TE+M+KGSLLDFLK +G + LP+L+D +AQIA+GMAYIER NYI
Sbjct: 305 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 364
Query: 394 HRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 453
HRDLRAAN+LV E+L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKS
Sbjct: 365 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 424
Query: 454 DVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDP 513
DVWSFGIL E+VT G++PYPG N +V+ + +GYRMP + CP+ L+++M +CWK+
Sbjct: 425 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 484
Query: 514 DERPTFEYIQSFLEDYFTATEPQYQ 538
+ERPTF+Y+QS L+D++TATE QYQ
Sbjct: 485 EERPTFDYLQSVLDDFYTATEGQYQ 509
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 583 bits (1503), Expect = e-166
Identities = 277/445 (62%), Positives = 353/445 (79%), Gaps = 2/445 (0%)
Query: 95 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQ 154
+ +AL+ YE DL F+KGE+ +I+ + G+WW+A+S+ TG+ G+IP N+VA A+S++
Sbjct: 65 LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
Query: 155 AEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKI 214
E W+F + RKDAER LL PGN G FL+RESE+T G++SLS+RD+D+ +G+ VKHYKI
Sbjct: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
Query: 215 RKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPR 274
R LDNGG+YI+ R F L +LV+HYT +DGLC +L+ C T KPQ +D WE+PR
Sbjct: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW-EDEWEVPR 242
Query: 275 ESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVP 334
E+L+L +LG G FGEVWMG +NG TKVA+K+LK G+M P+AFL EA +MK+L+H +LV
Sbjct: 243 ETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVR 302
Query: 335 LYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIH 394
LYAVV++EPIYI+TE+M GSL+DFLK G L + +L+DMAAQIA+GMA+IE NYIH
Sbjct: 303 LYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIH 362
Query: 395 RDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 454
RDLRAANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA YG FTIKSD
Sbjct: 363 RDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSD 422
Query: 455 VWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPD 514
VWSFGIL TE+VT GR+PYPGM N EV++ +ERGYRM P CPE L++LM LCWK+ P+
Sbjct: 423 VWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPE 482
Query: 515 ERPTFEYIQSFLEDYFTATEPQYQP 539
+RPTF+Y++S LED+FTATE QYQP
Sbjct: 483 DRPTFDYLRSVLEDFFTATEGQYQP 507
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 583 bits (1503), Expect = e-166
Identities = 277/445 (62%), Positives = 353/445 (79%), Gaps = 2/445 (0%)
Query: 95 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQ 154
+ +AL+ YE DL F+KGE+ +I+ + G+WW+A+S+ TG+ G+IP N+VA A+S++
Sbjct: 65 LVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFNFVAKANSLE 123
Query: 155 AEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKI 214
E W+F + RKDAER LL PGN G FL+RESE+T G++SLS+RD+D+ +G+ VKHYKI
Sbjct: 124 PEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKI 183
Query: 215 RKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPR 274
R LDNGG+YI+ R F L +LV+HYT +DGLC +L+ C T KPQ +D WE+PR
Sbjct: 184 RNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW-EDEWEVPR 242
Query: 275 ESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVP 334
E+L+L +LG G FGEVWMG +NG TKVA+K+LK G+M P+AFL EA +MK+L+H +LV
Sbjct: 243 ETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVR 302
Query: 335 LYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIH 394
LYAVV++EPIYI+TE+M GSL+DFLK G L + +L+DMAAQIA+GMA+IE NYIH
Sbjct: 303 LYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIH 362
Query: 395 RDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 454
RDLRAANILV + L CKIADFGLARLIEDNEYTAR+GAKFPIKWTAPEA YG FTIKSD
Sbjct: 363 RDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSD 422
Query: 455 VWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPD 514
VWSFGIL TE+VT GR+PYPGM N EV++ +ERGYRM P CPE L++LM LCWK+ P+
Sbjct: 423 VWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPE 482
Query: 515 ERPTFEYIQSFLEDYFTATEPQYQP 539
+RPTF+Y++S LED+FTATE QYQP
Sbjct: 483 DRPTFDYLRSVLEDFFTATEGQYQP 507
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 557 bits (1436), Expect = e-159
Identities = 277/443 (62%), Positives = 340/443 (76%), Gaps = 5/443 (1%)
Query: 97 VALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAE 156
VALYDY A DL KGE+ Q++ T GDWW ARS+ TG+ GY+PSN+VA +S++ E
Sbjct: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
Query: 157 EWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRK 216
W+F GRK+AER LL P N+ G FL+RESET KGA+SLS++D +G+ +KHYKIR
Sbjct: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTT-QGELIKHYKIRC 181
Query: 217 LDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRES 276
LD GGYYI+ R F +LQ LV+HY++ DGLC +LT C PQ A+D WEIPR+S
Sbjct: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPW-AQDEWEIPRQS 240
Query: 277 LRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLY 336
LRL KLG G FGEVWMG + KVAIKTLK GTM PEAFL EA +MK L+H++LV LY
Sbjct: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
Query: 337 AVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRD 396
AVV++EPIYIVTE+M++G LLDFLK +G L LP+L+DM+AQIA+GMAYIERMN IHRD
Sbjct: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
Query: 397 LRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 456
LRAANILV E L CKIADFGLAR+I D+EYTA++GAKFPIKWTAPEA +G FTIK+DVW
Sbjct: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
Query: 457 SFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE-LMNLCWKKDPDE 515
SFG+L E+VT GRVPYPGM N EV+ +ERGYRMP P CP L+ ++ CW+ P+E
Sbjct: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
Query: 516 RPTFEYIQSFLEDYFTATEPQYQ 538
RPTFE++QS LED++TATE QY+
Sbjct: 480 RPTFEFLQSVLEDFYTATERQYE 502
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 464 bits (1194), Expect = e-131
Identities = 238/462 (51%), Positives = 313/462 (67%), Gaps = 21/462 (4%)
Query: 96 FVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNG-------YIPSNYVA 148
FVAL+DY+ART EDLSF+ G++ Q+++ WW AR + ++G YIPSNYVA
Sbjct: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
Query: 149 PADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDN 208
S+QAE W+FG +GR DAE+ LL N+ G FL+RESE+ KG +SLS+ D G
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161
Query: 209 VKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVK-PQTQGLAK 267
VKHY+I++LD GG+++T R F TL + V HYT+ +DGLC KL C ++ P L+
Sbjct: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221
Query: 268 ---DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIM 324
D WEI R S++L +LG G FGEVW G WN TT VA+KTLKPG+M P FL+EAQIM
Sbjct: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
Query: 325 KKLRHDKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADG 383
K LRH KL+ LYAV + E+PIYI+TE M GSL ++L+ G + L Q VDMAAQ+A G
Sbjct: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
Query: 384 MAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIE-DNE--YTARQGAKFPIKWTA 440
MAY+E NYIHRDL A N+LVGE+ + K+ADFGLAR+ + DNE Y +R K P+KWTA
Sbjct: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
Query: 441 PEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPES 500
PEA +F+IKSDVWSFGIL E++T G++PY GM +V++ + + YR+P P CP+
Sbjct: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
Query: 501 LHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGEN 542
+ +M CW +P ERPTFE ++ LEDYF T+ Y N
Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSYSDANN 502
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 379 bits (973), Expect = e-105
Identities = 198/446 (44%), Positives = 275/446 (61%), Gaps = 14/446 (3%)
Query: 96 FVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATG---KNGYIPSNYVAPADS 152
+V L+D+++RT E+LSF+ G+ F + E WW G GY+P NY+A ++
Sbjct: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
Query: 153 IQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHY 212
+++E W+FG + R +A R L GN G FL+R SE Y LS+RD +R HY
Sbjct: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVR-----HY 127
Query: 213 KIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAK-DAWE 271
KI + G ++ F +L +LV ++ A L H L P K + + L D WE
Sbjct: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYH--RAQSLSHGLRLAAPCRKHEPEPLPHWDDWE 185
Query: 272 IPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQ-EAQIMKKLRHD 330
PRE L KLG G FGEV+ G W +VAIK + ++ + LQ E Q MKKLRH
Sbjct: 186 RPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHK 245
Query: 331 KLVPLYAVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIER 389
++ LYAVVS +P+YI+TE M+KGSLL+ L++ D K L + +L+D+A Q+A+GM Y+E
Sbjct: 246 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 305
Query: 390 MNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 449
NYIHRDL A NILVGEN +CK+ DFGLARLI+++ Y + P KWTAPEA G +
Sbjct: 306 QNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHY 364
Query: 450 TIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCW 509
+ KSDVWSFGIL E+ ++G+VPYPGM N E +V+ GYRMPCP CP S+H+LM CW
Sbjct: 365 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCW 424
Query: 510 KKDPDERPTFEYIQSFLEDYFTATEP 535
+DP++RP F+ ++ L + + P
Sbjct: 425 CRDPEQRPCFKALRERLSSFTSYENP 450
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 369 bits (947), Expect = e-102
Identities = 198/442 (44%), Positives = 281/442 (63%), Gaps = 15/442 (3%)
Query: 95 IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153
+FVALYD+ A LS KGE+ +++ N G+W EA++ G++PSNY+ P +S+
Sbjct: 65 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYITPVNSL 122
Query: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213
+ WY G + R AE LL + N G FLVRESE++ G S+S+R V HY+
Sbjct: 123 EKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YEGRVYHYR 175
Query: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV-KPQTQGLAK--DAW 270
I +G Y+++ ++F+TL +LV H++ ADGL L P KP G++ D W
Sbjct: 176 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 235
Query: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH 329
E+ R + ++ KLG G +GEV+ G W + VA+KTLK TM E FL+EA +MK+++H
Sbjct: 236 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 295
Query: 330 DKLVPLYAVVSEEP-IYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388
LV L V + EP YI+TEFM+ G+LLD+L+E + + + L+ MA QI+ M Y+E
Sbjct: 296 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 355
Query: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448
+ N+IHRDL A N LVGEN + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y +
Sbjct: 356 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK 415
Query: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508
F+IKSDVW+FG+L E+ T G PYPG+ +V E +E+ YRM P+GCPE ++ELM C
Sbjct: 416 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRAC 475
Query: 509 WKKDPDERPTFEYIQSFLEDYF 530
W+ +P +RP+F I E F
Sbjct: 476 WQWNPSDRPSFAEIHQAFETMF 497
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 369 bits (947), Expect = e-102
Identities = 198/442 (44%), Positives = 281/442 (63%), Gaps = 15/442 (3%)
Query: 95 IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153
+FVALYD+ A LS KGE+ +++ N G+W EA++ G++PSNY+ P +S+
Sbjct: 84 LFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYITPVNSL 141
Query: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213
+ WY G + R AE LL + N G FLVRESE++ G S+S+R V HY+
Sbjct: 142 EKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YEGRVYHYR 194
Query: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV-KPQTQGLAK--DAW 270
I +G Y+++ ++F+TL +LV H++ ADGL L P KP G++ D W
Sbjct: 195 INTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKW 254
Query: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH 329
E+ R + ++ KLG G +GEV+ G W + VA+KTLK TM E FL+EA +MK+++H
Sbjct: 255 EMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 314
Query: 330 DKLVPLYAVVSEEP-IYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388
LV L V + EP YI+TEFM+ G+LLD+L+E + + + L+ MA QI+ M Y+E
Sbjct: 315 PNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLE 374
Query: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448
+ N+IHRDL A N LVGEN + K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y +
Sbjct: 375 KKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNK 434
Query: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508
F+IKSDVW+FG+L E+ T G PYPG+ +V E +E+ YRM P+GCPE ++ELM C
Sbjct: 435 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRAC 494
Query: 509 WKKDPDERPTFEYIQSFLEDYF 530
W+ +P +RP+F I E F
Sbjct: 495 WQWNPSDRPSFAEIHQAFETMF 516
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 368 bits (944), Expect = e-102
Identities = 202/455 (44%), Positives = 279/455 (61%), Gaps = 15/455 (3%)
Query: 95 IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153
+FVALYD+ A LS KGE+ +++ N G+W E RS G++PSNY+ P +S+
Sbjct: 96 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 153
Query: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213
+ WY G + R AE LL + N G FLVRESE++ G S+S+R V HY+
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 206
Query: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV-KPQTQGLAK--DAW 270
I +G Y+T ++F TL +LV H++ ADGL L P KP G++ D W
Sbjct: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 266
Query: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH 329
E+ R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA +MK+++H
Sbjct: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326
Query: 330 DKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388
LV L V + E P YIVTE+M G+LLD+L+E + + + L+ MA QI+ M Y+E
Sbjct: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386
Query: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448
+ N+IHRDL A N LVGEN V K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446
Query: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508
F+IKSDVW+FG+L E+ T G PYPG+ +V + +E+GYRM P+GCP ++ELM C
Sbjct: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506
Query: 509 WKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL 543
WK P +RP+F E F + + E L
Sbjct: 507 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 368 bits (944), Expect = e-102
Identities = 202/455 (44%), Positives = 279/455 (61%), Gaps = 15/455 (3%)
Query: 95 IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153
+FVALYD+ A LS KGE+ +++ N G+W E RS G++PSNY+ P +S+
Sbjct: 111 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 168
Query: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213
+ WY G + R AE LL + N G FLVRESE++ G S+S+R V HY+
Sbjct: 169 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 221
Query: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV-KPQTQGLAK--DAW 270
I +G Y+T ++F TL +LV H++ ADGL L P KP G++ D W
Sbjct: 222 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 281
Query: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH 329
E+ R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA +MK+++H
Sbjct: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341
Query: 330 DKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388
LV L V + E P YIVTE+M G+LLD+L+E + + + L+ MA QI+ M Y+E
Sbjct: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401
Query: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448
+ N+IHRDL A N LVGEN V K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461
Query: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508
F+IKSDVW+FG+L E+ T G PYPG+ +V + +E+GYRM P+GCP ++ELM C
Sbjct: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521
Query: 509 WKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL 543
WK P +RP+F E F + + E L
Sbjct: 522 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 368 bits (944), Expect = e-102
Identities = 202/455 (44%), Positives = 279/455 (61%), Gaps = 15/455 (3%)
Query: 95 IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153
+FVALYD+ A LS KGE+ +++ N G+W E RS G++PSNY+ P +S+
Sbjct: 96 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 153
Query: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213
+ WY G + R AE LL + N G FLVRESE++ G S+S+R V HY+
Sbjct: 154 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 206
Query: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV-KPQTQGLAK--DAW 270
I +G Y+T ++F TL +LV H++ ADGL L P KP G++ D W
Sbjct: 207 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 266
Query: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH 329
E+ R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA +MK+++H
Sbjct: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326
Query: 330 DKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388
LV L V + E P YIVTE+M G+LLD+L+E + + + L+ MA QI+ M Y+E
Sbjct: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386
Query: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448
+ N+IHRDL A N LVGEN V K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446
Query: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508
F+IKSDVW+FG+L E+ T G PYPG+ +V + +E+GYRM P+GCP ++ELM C
Sbjct: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506
Query: 509 WKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL 543
WK P +RP+F E F + + E L
Sbjct: 507 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 368 bits (944), Expect = e-102
Identities = 202/455 (44%), Positives = 279/455 (61%), Gaps = 15/455 (3%)
Query: 95 IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153
+FVALYD+ A LS KGE+ +++ N G+W E RS G++PSNY+ P +S+
Sbjct: 75 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 132
Query: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213
+ WY G + R AE LL + N G FLVRESE++ G S+S+R V HY+
Sbjct: 133 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 185
Query: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV-KPQTQGLAK--DAW 270
I +G Y+T ++F TL +LV H++ ADGL L P KP G++ D W
Sbjct: 186 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 245
Query: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH 329
E+ R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA +MK+++H
Sbjct: 246 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 305
Query: 330 DKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388
LV L V + E P YIVTE+M G+LLD+L+E + + + L+ MA QI+ M Y+E
Sbjct: 306 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 365
Query: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448
+ N+IHRDL A N LVGEN V K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 366 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 425
Query: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508
F+IKSDVW+FG+L E+ T G PYPG+ +V + +E+GYRM P+GCP ++ELM C
Sbjct: 426 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 485
Query: 509 WKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL 543
WK P +RP+F E F + + E L
Sbjct: 486 WKWSPADRPSFAETHQAFETMFHDSSISEEVAEEL 520
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 367 bits (943), Expect = e-101
Identities = 200/442 (45%), Positives = 275/442 (62%), Gaps = 15/442 (3%)
Query: 95 IFVALYDYEARTTEDLSFKKGERFQIIN-NTEGDWWEARSIATGKNGYIPSNYVAPADSI 153
+FVALYD+ A LS KGE+ +++ N G+W E RS G++PSNY+ P +S+
Sbjct: 90 LFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYITPVNSL 147
Query: 154 QAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYK 213
+ WY G + R AE LL + N G FLVRESE++ G S+S+R V HY+
Sbjct: 148 EKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYR 200
Query: 214 IRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTV-KPQTQGLAK--DAW 270
I +G Y+T ++F TL +LV H++ ADGL L P KP G++ D W
Sbjct: 201 INTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKW 260
Query: 271 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRH 329
E+ R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA +MK+++H
Sbjct: 261 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 320
Query: 330 DKLVPLYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIE 388
LV L V + E P YIVTE+M G+LLD+L+E + + + L+ MA QI+ M Y+E
Sbjct: 321 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 380
Query: 389 RMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 448
+ N+IHRDL A N LVGEN V K+ADFGL+RL+ + YTA GAKFPIKWTAPE+ Y
Sbjct: 381 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 440
Query: 449 FTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLC 508
F+IKSDVW+FG+L E+ T G PYPG+ +V + +E+GYRM P+GCP ++ELM C
Sbjct: 441 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 500
Query: 509 WKKDPDERPTFEYIQSFLEDYF 530
WK P +RP+F E F
Sbjct: 501 WKWSPADRPSFAETHQAFETMF 522
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 348 bits (894), Expect = 5e-96
Identities = 189/469 (40%), Positives = 271/469 (57%), Gaps = 12/469 (2%)
Query: 61 PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120
P GG G + VP+ + +F+ALYD+ AR +LS ++G+R
Sbjct: 21 PAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCA 80
Query: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPA--DSIQAEEWYFGKMGRKDAERLLLNPGNQ 178
+ G + R G +P +VA A +++ + WYF + R A++LLL+P N+
Sbjct: 81 LEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNE 140
Query: 179 RGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVK 238
G FL+R SE++ G YSLS+R + V HY++ +G Y+ F L++L+
Sbjct: 141 PGAFLIRPSESSLGGYSLSVRAQAK-----VCHYRVSMAADGSLYLQKGRLFPGLEELLT 195
Query: 239 HYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG 298
+Y + + + L C K Q D WE P L KLG+G FGEVW G W G
Sbjct: 196 YYKANWKLIQNPLLQPCMPQKAPRQ----DVWERPHSEFALGRKLGEGYFGEVWEGLWLG 251
Query: 299 TTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSE-EPIYIVTEFMSKGSLL 357
+ VAIK +K M +E Q +K LRH++L+ L+AV S EP+YIVTE M KG+L
Sbjct: 252 SLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQ 311
Query: 358 DFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGL 417
FL +G+ L+LP L+ A Q+A+GM+Y+E +HRDL A N+LV + L CK+ADFGL
Sbjct: 312 AFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGL 371
Query: 418 ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMV 477
ARL++D+ Y+ +K P+KWTAPEAA Y F+ KSDVWSFG+L E+ T G+ PY GM
Sbjct: 372 ARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMT 431
Query: 478 NREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFL 526
N E L+Q+ RGYR+P P CP ++ LM CW+ P+ERP+F ++ L
Sbjct: 432 NHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKL 480
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 320 bits (819), Expect = 3e-87
Identities = 174/451 (38%), Positives = 269/451 (59%), Gaps = 17/451 (3%)
Query: 95 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVA--PADS 152
I VA+YD++A DL ++G+ + I+ + WW AR G GYIPSNYV +++
Sbjct: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
Query: 153 IQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDN---V 209
+ EWY M R AE+LL + + G F+VR+S + G Y++S+ + + G+
Sbjct: 242 LDQYEWYCRNMNRSKAEQLLRSEDKEGG-FMVRDS-SQPGLYTVSL--YTKFGGEGSSGF 297
Query: 210 KHYKIRKLDNGG--YYITTRAQFDTLQKLVKHYTEHADGLCHKL---TTVCPTVKPQTQG 264
+HY I++ YY+ + F ++ ++++++ +A GL +L +V P T G
Sbjct: 298 RHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAG 357
Query: 265 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIM 324
+ + WEI L +LG G FG V +G W KVAIK ++ G M E F++EA++M
Sbjct: 358 FSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVM 417
Query: 325 KKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADG 383
KL H KLV LY V +++ PIYIVTEFM +G LL+FL++ G + + L+ M + +G
Sbjct: 418 MKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEG 476
Query: 384 MAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 443
M Y+ER ++IHRDL A N LV E V K++DFG+AR + D++YT+ GAKFP+KW PE
Sbjct: 477 MEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEV 536
Query: 444 ALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 503
Y RF+ KSDVWSFG+L E+ T+GR+P+ N EV+ V RG+R+ P+ ++E
Sbjct: 537 FNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYE 596
Query: 504 LMNLCWKKDPDERPTFEYIQSFLEDYFTATE 534
+M CW++ P+ RP+FE + +++ E
Sbjct: 597 VMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 318 bits (814), Expect = 1e-86
Identities = 171/455 (37%), Positives = 265/455 (58%), Gaps = 15/455 (3%)
Query: 82 PSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGY 141
P++ P T + VALYDY DL +KG+ + I+ + WW AR G+ GY
Sbjct: 206 PAAAPVS-TSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGY 263
Query: 142 IPSNYVAPA-DSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRD 200
IPSNYV A DSI+ EWY M R AE+LL G + G F+VR+S G Y++S+
Sbjct: 264 IPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGG-FIVRDSSKA-GKYTVSV-- 319
Query: 201 WDEIRGDN---VKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPT 257
+ + GD ++HY + YY+ + F T+ +L+ ++ ++ GL +L
Sbjct: 320 FAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQ 379
Query: 258 VK---PQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMP 314
P T GL +WEI + L +LG G FG V G W G VAIK +K G+M
Sbjct: 380 QNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSE 439
Query: 315 EAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLKEGDGKYLKLPQL 373
+ F++EA++M L H+KLV LY V +++ PI+I+TE+M+ G LL++L+E ++ + QL
Sbjct: 440 DEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRF-QTQQL 498
Query: 374 VDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAK 433
++M + + M Y+E ++HRDL A N LV + V K++DFGL+R + D+EYT+ G+K
Sbjct: 499 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSK 558
Query: 434 FPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPC 493
FP++W+ PE +Y +F+ KSD+W+FG+L E+ + G++PY N E E + +G R+
Sbjct: 559 FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR 618
Query: 494 PQGCPESLHELMNLCWKKDPDERPTFEYIQSFLED 528
P E ++ +M CW + DERPTF+ + S + D
Sbjct: 619 PHLASEKVYTIMYSCWHEKADERPTFKILLSNILD 653
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 317 bits (811), Expect = 2e-86
Identities = 170/432 (39%), Positives = 255/432 (59%), Gaps = 17/432 (3%)
Query: 98 ALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAP--ADSIQA 155
ALYD+ R +L+ ++ E + I+ WW+AR G G IPSNYV +++
Sbjct: 89 ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147
Query: 156 EEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSI----RDWDEIRGDNVKH 211
EWY + R AE LL + G F+VR+S G+Y++S+ R E +KH
Sbjct: 148 YEWYHRNITRNQAEHLLRQESKE-GAFIVRDSRHL-GSYTISVFMGARRSTEAA---IKH 202
Query: 212 YKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKL---TTVCPTVKPQTQGLAKD 268
Y+I+K D+G +Y+ R F ++ +L+ ++ +A GL +L + + P T G + +
Sbjct: 203 YQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYE 262
Query: 269 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLR 328
WEI L ++G G FG V +G W +VAIK + G+M E F++EA++M KL
Sbjct: 263 KWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLS 322
Query: 329 HDKLVPLYAV-VSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYI 387
H KLV LY V + +P+YIVTEFM G LL++L+E GK L+ L+ + I +GM Y+
Sbjct: 323 HSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYL 381
Query: 388 ERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 447
ER YIHRDL A N LV + KI+DFG+ R + D+EY + GAKFPIKW+ PE L+
Sbjct: 382 ERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFN 441
Query: 448 RFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNL 507
+++ KSDVWSFG+L E+ T+G++P+ N +V+E + G+R+ P P S++E+M
Sbjct: 442 KYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYS 501
Query: 508 CWKKDPDERPTF 519
CW + P+ RPTF
Sbjct: 502 CWHEKPEGRPTF 513
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 314 bits (805), Expect = 1e-85
Identities = 165/436 (37%), Positives = 260/436 (59%), Gaps = 14/436 (3%)
Query: 94 TIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPA--D 151
T+ +ALYDY+ ++L+ ++ E + +++++E WW + G GY+PS+Y+ +
Sbjct: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPN 232
Query: 152 SIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDN--V 209
+++ EWY + R AE+LLL+ G + G F+VR+S T G Y++S+ + +N +
Sbjct: 233 NLETYEWYNKSISRDKAEKLLLDTGKE-GAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
Query: 210 KHYKIRKLDNGG--YYITTRAQFDTLQKLVKHYTEHADGLCHKLT-TVC--PTVKPQTQG 264
KHY I++ ++ YY+ + FD++ L+ ++ + GL +L VC P T G
Sbjct: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
Query: 265 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIM 324
L W I L ++G G FG V +G W KVAIKT++ G M E F++EA++M
Sbjct: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
Query: 325 KKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADG 383
KL H KLV LY V E+ PI +V EFM G L D+L+ G + L+ M + +G
Sbjct: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAA-ETLLGMCLDVCEG 469
Query: 384 MAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 443
MAY+E IHRDL A N LVGEN V K++DFG+ R + D++YT+ G KFP+KW +PE
Sbjct: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
Query: 444 ALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 503
+ R++ KSDVWSFG+L E+ ++G++PY N EV+E + G+R+ P+ +++
Sbjct: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
Query: 504 LMNLCWKKDPDERPTF 519
+MN CWK+ P++RP F
Sbjct: 590 IMNHCWKERPEDRPAF 605
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 293 bits (749), Expect = 4e-79
Identities = 174/460 (37%), Positives = 259/460 (56%), Gaps = 31/460 (6%)
Query: 79 SVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGK 138
S + +++P+G T +A Y++ +DL F KG+ I+ T+ W G+
Sbjct: 2 SAIQAAWPSG-----TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGR 56
Query: 139 NGYIPSNYVAPADSIQAEE------WYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKG 192
G IP+NYV + ++A W+ GK+ R+ AERLL P + G+FLVRES G
Sbjct: 57 EGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPG 114
Query: 193 AYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLT 252
Y+L + V+HY+I I F+ L +LV+HYT ADGLC +L
Sbjct: 115 DYTLCVSC-----DGKVEHYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLI 168
Query: 253 ---TVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKP 309
+ TV Q + + W + + L+L +G+G FG+V +G + G KVA+K +K
Sbjct: 169 KPKVMEGTVAAQDE-FYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK- 225
Query: 310 GTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP--IYIVTEFMSKGSLLDFLKEGDGKY 367
+AFL EA +M +LRH LV L V+ EE +YIVTE+M+KGSL+D+L+
Sbjct: 226 NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV 285
Query: 368 LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYT 427
L L+ + + + M Y+E N++HRDL A N+LV E+ V K++DFGL + + T
Sbjct: 286 LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT 345
Query: 428 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVER 487
K P+KWTAPEA +F+ KSDVWSFGIL E+ + GRVPYP + ++V+ +VE+
Sbjct: 346 G----KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK 401
Query: 488 GYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 527
GY+M P GCP +++E+M CW D RP+F ++ LE
Sbjct: 402 GYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLE 441
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,100,765
Number of Sequences: 37866
Number of extensions: 1062823
Number of successful extensions: 5717
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 798
Number of HSP's successfully gapped in prelim test: 293
Number of HSP's that attempted gapping in prelim test: 3290
Number of HSP's gapped (non-prelim): 1482
length of query: 543
length of database: 18,247,518
effective HSP length: 107
effective length of query: 436
effective length of database: 14,195,856
effective search space: 6189393216
effective search space used: 6189393216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.