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Search of human proteins with 4885609
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
(536 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 1096 0.0
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 1096 0.0
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 819 0.0
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 763 0.0
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 745 0.0
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 716 0.0
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 716 0.0
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 716 0.0
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens] 669 0.0
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 587 e-168
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 566 e-161
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 566 e-161
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 560 e-160
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 560 e-160
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 553 e-157
gi|4503787 fyn-related kinase [Homo sapiens] 468 e-132
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 374 e-104
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 364 e-100
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 363 e-100
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 359 3e-99
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 359 3e-99
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 359 3e-99
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 359 3e-99
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 359 3e-99
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 354 1e-97
gi|148596974 TXK tyrosine kinase [Homo sapiens] 328 6e-90
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 322 4e-88
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 318 6e-87
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 305 5e-83
gi|187475373 c-src tyrosine kinase [Homo sapiens] 294 1e-79
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 1096 bits (2834), Expect = 0.0
Identities = 536/536 (100%), Positives = 536/536 (100%)
Query: 1 MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE 60
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
Sbjct: 1 MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE 60
Query: 61 PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD 120
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
Sbjct: 61 PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD 120
Query: 121 WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES 180
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
Sbjct: 121 WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES 180
Query: 181 ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL 240
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
Sbjct: 181 ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL 240
Query: 241 CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL 300
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
Sbjct: 241 CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL 300
Query: 301 KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY 360
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
Sbjct: 301 KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY 360
Query: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT 420
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
Sbjct: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT 420
Query: 421 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
Sbjct: 421 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480
Query: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Sbjct: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 1096 bits (2834), Expect = 0.0
Identities = 536/536 (100%), Positives = 536/536 (100%)
Query: 1 MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE 60
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
Sbjct: 1 MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE 60
Query: 61 PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD 120
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
Sbjct: 61 PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD 120
Query: 121 WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES 180
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
Sbjct: 121 WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES 180
Query: 181 ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL 240
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
Sbjct: 181 ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL 240
Query: 241 CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL 300
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
Sbjct: 241 CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL 300
Query: 301 KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY 360
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
Sbjct: 301 KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY 360
Query: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT 420
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
Sbjct: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT 420
Query: 421 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
Sbjct: 421 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480
Query: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Sbjct: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 819 bits (2116), Expect = 0.0
Identities = 401/543 (73%), Positives = 450/543 (82%), Gaps = 7/543 (1%)
Query: 1 MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE 60
MG KSK + + E + A T P + +G + F+ +
Sbjct: 1 MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT 60
Query: 61 P-------KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQI 113
P FGG +SS +V L GGVT FVALYDYE+RT DLSFKKGER QI
Sbjct: 61 PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI 120
Query: 114 VNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRG 173
+NNTEGDWW A S++TG+ GYIPSNYVAP+DSIQAEEWYFGK+ R+++ERLLLN N RG
Sbjct: 121 INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG 180
Query: 174 TFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYY 233
FLVRESETTKGAY LS+ D+D +G NVKHYKIRKLD+GG+YIT+R QF++LQ+LV +Y
Sbjct: 181 IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY 240
Query: 234 SKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 293
++HADGLCH+LTTVCPT KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
Sbjct: 241 TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 300
Query: 294 RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFL 353
+VAIKTLKPGTM PEAFLQEAQ+MKKLRH+KLV LYAVVSEEPIYIVTE+MSKGSLLDFL
Sbjct: 301 KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL 360
Query: 354 KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413
K GKYL+LPQLVDMAAQIA GMAY+ERMNY+HRDLRAANILVGENLVCK+ADFGLARL
Sbjct: 361 KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL 420
Query: 414 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNRE 473
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL TEL TKGRVPYPGMVNRE
Sbjct: 421 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE 480
Query: 474 VLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPG 533
VL+QVERGYRMPCP CPESLH+LM CW+K+P+ERPTFEY+Q+FLEDYFT+TEPQYQPG
Sbjct: 481 VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG 540
Query: 534 ENL 536
ENL
Sbjct: 541 ENL 543
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 763 bits (1970), Expect = 0.0
Identities = 366/475 (77%), Positives = 417/475 (87%), Gaps = 4/475 (0%)
Query: 63 LFGGFNSSD-TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
+FGG NSS T T R G GVT FVALYDYE+RTE DLSF KGE+ QI+N++EGDW
Sbjct: 63 VFGGVNSSSHTGTLRTRGGT---GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDW 119
Query: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
W A SL+TG+TGYIPSNYVAP DSIQAEEWYFGK+ R+++ER LL+ NPRGTFL+RESE
Sbjct: 120 WEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179
Query: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
TTKGAY LS+ D+D+ KG +VKHYKIRKLD+GG+YIT+R QF +LQQLV +YS+ ADGLC
Sbjct: 180 TTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLC 239
Query: 242 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK 301
LT + + PQT GLAKDAWE+ R SL LE KLGQGCF EVW+GTWNG T+VAIKTLK
Sbjct: 240 FNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLK 299
Query: 302 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL 361
PGTMSPE+FL+EAQ+MKKL+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK G+ L
Sbjct: 300 PGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRAL 359
Query: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421
+LP LVDMAAQ+A+GMAY+ERMNY+HRDLR+ANILVG L+CK+ADFGLARLIEDNEYTA
Sbjct: 360 KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTA 419
Query: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481
RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QVERG
Sbjct: 420 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERG 479
Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
YRMPCP +CP SLH+LM CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL
Sbjct: 480 YRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 534
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 745 bits (1923), Expect = 0.0
Identities = 362/478 (75%), Positives = 413/478 (86%), Gaps = 7/478 (1%)
Query: 63 LFGGFNSSD-TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
+FGG NSS T T R G GVT FVALYDYE+RTE DLSF KGE+ QI+N++EGDW
Sbjct: 63 VFGGVNSSSHTGTLRTRGGT---GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDW 119
Query: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
W A SL+TG+TGYIPSNYVAP DSIQAEEWYFGK+ R+++ER LL+ NPRGTFL+RESE
Sbjct: 120 WEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179
Query: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
TTKGAY LS+ D+D+ KG +VKHYKIRKLD+GG+YIT+R QF +LQQLV +YS+ A GLC
Sbjct: 180 TTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLC 239
Query: 242 HRLTTVCPTSKPQTQGLA---KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIK 298
RL C P+ L+ KD WEIPRESL+L +LG G FGEVWMGTWNG T+VAIK
Sbjct: 240 CRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIK 299
Query: 299 TLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETG 358
TLKPGTMSPE+FL+EAQ+MKKL+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK G
Sbjct: 300 TLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEG 359
Query: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE 418
+ L+LP LVDMAAQ+A+GMAY+ERMNY+HRDLR+ANILVG L+CK+ADFGLARLIEDNE
Sbjct: 360 RALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNE 419
Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478
YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QV
Sbjct: 420 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQV 479
Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
ERGYRMPCP +CP SLH+LM CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL
Sbjct: 480 ERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 537
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 716 bits (1848), Expect = 0.0
Identities = 356/530 (67%), Positives = 418/530 (78%), Gaps = 10/530 (1%)
Query: 5 KSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLF 64
K +P ++ LE +GA P T ++PAS+ H + F+ A P
Sbjct: 8 KLEPVATAKEDAGLEGDFRSYGAADHYGP-DPTKARPASSFAHIPNYSNFSSQAINP--- 63
Query: 65 GGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLA 124
GF S T+ G GVT F+ALYDYE+RTE DL+F KGE+ I+NNTEGDWW A
Sbjct: 64 -GFLDSGTIR-----GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117
Query: 125 HSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184
SLS+G+TG IPSNYVAP DSIQAEEWYFGKI R+++ER LL+ NP+G FL+RESETTK
Sbjct: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177
Query: 185 GAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL 244
GAY LS+ D+D +G +VKHYKIRKLD GG+YIT+R QFNS+Q+LV +Y + DGLC+ L
Sbjct: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237
Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT 304
C KPQT GLAKDAWEI R S+ LE +LG GCFG+VW+GTWNG+T+VA+KTLKPGT
Sbjct: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297
Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364
MSP+AFL+EAQVMK LRH+KLVQLYAVVSEEPIYIVTE+M GSLLDFLK G+ LRLP
Sbjct: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357
Query: 365 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 424
QLVDMAAQ+A GMAY+ERMNY+HRDLRAANILVGE L CK+ADFGLARLI+D+EY QG
Sbjct: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417
Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484
+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL TKGR+PYPGM REVL+QVE+GY M
Sbjct: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477
Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534
PCPP CP SL++ M Q WR +PEERPTFEYLQ+FLEDYFTS EPQYQPG+
Sbjct: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 716 bits (1848), Expect = 0.0
Identities = 356/530 (67%), Positives = 418/530 (78%), Gaps = 10/530 (1%)
Query: 5 KSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLF 64
K +P ++ LE +GA P T ++PAS+ H + F+ A P
Sbjct: 8 KLEPVATAKEDAGLEGDFRSYGAADHYGP-DPTKARPASSFAHIPNYSNFSSQAINP--- 63
Query: 65 GGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLA 124
GF S T+ G GVT F+ALYDYE+RTE DL+F KGE+ I+NNTEGDWW A
Sbjct: 64 -GFLDSGTIR-----GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117
Query: 125 HSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184
SLS+G+TG IPSNYVAP DSIQAEEWYFGKI R+++ER LL+ NP+G FL+RESETTK
Sbjct: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177
Query: 185 GAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL 244
GAY LS+ D+D +G +VKHYKIRKLD GG+YIT+R QFNS+Q+LV +Y + DGLC+ L
Sbjct: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237
Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT 304
C KPQT GLAKDAWEI R S+ LE +LG GCFG+VW+GTWNG+T+VA+KTLKPGT
Sbjct: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297
Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364
MSP+AFL+EAQVMK LRH+KLVQLYAVVSEEPIYIVTE+M GSLLDFLK G+ LRLP
Sbjct: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357
Query: 365 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 424
QLVDMAAQ+A GMAY+ERMNY+HRDLRAANILVGE L CK+ADFGLARLI+D+EY QG
Sbjct: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417
Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484
+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL TKGR+PYPGM REVL+QVE+GY M
Sbjct: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477
Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534
PCPP CP SL++ M Q WR +PEERPTFEYLQ+FLEDYFTS EPQYQPG+
Sbjct: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 716 bits (1848), Expect = 0.0
Identities = 356/530 (67%), Positives = 418/530 (78%), Gaps = 10/530 (1%)
Query: 5 KSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLF 64
K +P ++ LE +GA P T ++PAS+ H + F+ A P
Sbjct: 8 KLEPVATAKEDAGLEGDFRSYGAADHYGP-DPTKARPASSFAHIPNYSNFSSQAINP--- 63
Query: 65 GGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLA 124
GF S T+ G GVT F+ALYDYE+RTE DL+F KGE+ I+NNTEGDWW A
Sbjct: 64 -GFLDSGTIR-----GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117
Query: 125 HSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184
SLS+G+TG IPSNYVAP DSIQAEEWYFGKI R+++ER LL+ NP+G FL+RESETTK
Sbjct: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177
Query: 185 GAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL 244
GAY LS+ D+D +G +VKHYKIRKLD GG+YIT+R QFNS+Q+LV +Y + DGLC+ L
Sbjct: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237
Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT 304
C KPQT GLAKDAWEI R S+ LE +LG GCFG+VW+GTWNG+T+VA+KTLKPGT
Sbjct: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297
Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364
MSP+AFL+EAQVMK LRH+KLVQLYAVVSEEPIYIVTE+M GSLLDFLK G+ LRLP
Sbjct: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357
Query: 365 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 424
QLVDMAAQ+A GMAY+ERMNY+HRDLRAANILVGE L CK+ADFGLARLI+D+EY QG
Sbjct: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417
Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484
+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL TKGR+PYPGM REVL+QVE+GY M
Sbjct: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477
Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534
PCPP CP SL++ M Q WR +PEERPTFEYLQ+FLEDYFTS EPQYQPG+
Sbjct: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
Length = 482
Score = 669 bits (1725), Expect = 0.0
Identities = 333/475 (70%), Positives = 379/475 (79%), Gaps = 56/475 (11%)
Query: 63 LFGGFNSSD-TVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
+FGG NSS T T R G GVT FVALYDYE+RTE DLSF KGE+ QI+N++EGDW
Sbjct: 63 VFGGVNSSSHTGTLRTRGGT---GVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDW 119
Query: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
W A SL+TG+TGYIPSNYVAP DSIQAEEWYFGK+ R+++ER LL+ NPRGTFL+RESE
Sbjct: 120 WEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESE 179
Query: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
TTKGAY LS+ D+D+ KG +VKHYKIRKLD+GG+YIT+R QF +LQQLV +YS
Sbjct: 180 TTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS------- 232
Query: 242 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK 301
GTWNG T+VAIKTLK
Sbjct: 233 ---------------------------------------------GTWNGNTKVAIKTLK 247
Query: 302 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL 361
PGTMSPE+FL+EAQ+MKKL+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK G+ L
Sbjct: 248 PGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRAL 307
Query: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421
+LP LVDMAAQ+A+GMAY+ERMNY+HRDLR+ANILVG L+CK+ADFGLARLIEDNEYTA
Sbjct: 308 KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTA 367
Query: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481
RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QVERG
Sbjct: 368 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERG 427
Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
YRMPCP +CP SLH+LM CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL
Sbjct: 428 YRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 482
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 587 bits (1513), Expect = e-168
Identities = 291/504 (57%), Positives = 378/504 (75%), Gaps = 13/504 (2%)
Query: 28 GGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVT 87
GG F ++T + P P++ P G NS ++ T R +
Sbjct: 33 GGNTFSKTETSASPHCPVYVPDPTSTIKP---------GPNSHNSNTPGIREAGSEDIIV 83
Query: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147
VALYDYE+ DLSF+KG+++ ++ + G+WW A SL+T + GYIPSNYVA DS++
Sbjct: 84 --VALYDYEAIHHEDLSFQKGDQMVVLEES-GEWWKARSLATRKEGYIPSNYVARVDSLE 140
Query: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKI 207
EEW+F I+R+++ER LL N G+F++R+SETTKG+Y LSV D+D +G VKHYKI
Sbjct: 141 TEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKI 200
Query: 208 RKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPR 267
R LD+GGFYI+ R+ F++LQ+LV +Y K DGLC +L+ C +SKPQ + KDAWEIPR
Sbjct: 201 RTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQ-KPWEKDAWEIPR 259
Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQ 327
ESL+LE KLG G FGEVWM T+N T+VA+KT+KPG+MS EAFL EA VMK L+H+KLV+
Sbjct: 260 ESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVK 319
Query: 328 LYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387
L+AVV++EPIYI+TE+M+KGSLLDFLK + G LP+L+D +AQIA GMA++E+ NY+H
Sbjct: 320 LHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIH 379
Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 447
RDLRAANILV +LVCK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKSD
Sbjct: 380 RDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSD 439
Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 507
VWSFGILL E+ T GR+PYPGM N EV+ +ERGYRMP P CPE L+++M +CW+ PE
Sbjct: 440 VWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPE 499
Query: 508 ERPTFEYLQAFLEDYFTSTEPQYQ 531
ERPTFEY+Q+ L+D++T+TE QYQ
Sbjct: 500 ERPTFEYIQSVLDDFYTATESQYQ 523
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 566 bits (1459), Expect = e-161
Identities = 272/454 (59%), Positives = 352/454 (77%), Gaps = 4/454 (0%)
Query: 79 AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSN 138
A PL + +AL+ YE + DL F+KGE+L+I+ + G+WW A SL+TGQ G+IP N
Sbjct: 58 ASPLQDNLV--IALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFN 114
Query: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198
+VA ++S++ E W+F ++R+++ER LL N G+FL+RESE+T G++ LSV DFD +
Sbjct: 115 FVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQ 174
Query: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGL 258
G VKHYKIR LD+GGFYI+ R F L +LV +Y+ +DGLC RL+ C T KPQ
Sbjct: 175 GEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW 234
Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318
+D WE+PRE+L+L +LG G FGEVWMG +NG T+VA+K+LK G+MSP+AFL EA +MK
Sbjct: 235 -EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMK 293
Query: 319 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378
+L+H++LV+LYAVV++EPIYI+TEYM GSL+DFLK +G L + +L+DMAAQIA GMA
Sbjct: 294 QLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438
++E NY+HRDLRAANILV + L CK+ADFGLARLIEDNEYTAR+GAKFPIKWTAPEA
Sbjct: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498
YG FTIKSDVWSFGILLTE+ T GR+PYPGM N EV+ +ERGYRM P CPE L+ LM
Sbjct: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM 473
Query: 499 CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 532
CW++ PE+RPTF+YL++ LED+FT+TE QYQP
Sbjct: 474 RLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 566 bits (1459), Expect = e-161
Identities = 272/454 (59%), Positives = 352/454 (77%), Gaps = 4/454 (0%)
Query: 79 AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSN 138
A PL + +AL+ YE + DL F+KGE+L+I+ + G+WW A SL+TGQ G+IP N
Sbjct: 58 ASPLQDNLV--IALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKAQSLTTGQEGFIPFN 114
Query: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198
+VA ++S++ E W+F ++R+++ER LL N G+FL+RESE+T G++ LSV DFD +
Sbjct: 115 FVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQ 174
Query: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGL 258
G VKHYKIR LD+GGFYI+ R F L +LV +Y+ +DGLC RL+ C T KPQ
Sbjct: 175 GEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWW 234
Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318
+D WE+PRE+L+L +LG G FGEVWMG +NG T+VA+K+LK G+MSP+AFL EA +MK
Sbjct: 235 -EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMK 293
Query: 319 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378
+L+H++LV+LYAVV++EPIYI+TEYM GSL+DFLK +G L + +L+DMAAQIA GMA
Sbjct: 294 QLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438
++E NY+HRDLRAANILV + L CK+ADFGLARLIEDNEYTAR+GAKFPIKWTAPEA
Sbjct: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498
YG FTIKSDVWSFGILLTE+ T GR+PYPGM N EV+ +ERGYRM P CPE L+ LM
Sbjct: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM 473
Query: 499 CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 532
CW++ PE+RPTF+YL++ LED+FT+TE QYQP
Sbjct: 474 RLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 560 bits (1444), Expect = e-160
Identities = 267/443 (60%), Positives = 346/443 (78%), Gaps = 3/443 (0%)
Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
VALY Y+ DLSFKKGE+++++ G+WW A SL T + G+IPSNYVA ++++ E
Sbjct: 48 VALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLETE 106
Query: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
EW+F ITR+++ER LL N G FL+RESET KG++ LSV DFD G +KHYKIR
Sbjct: 107 EWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRS 166
Query: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269
LD+GG+YI+ R F + ++ +Y K ADGLC RL C + KPQ + KDAWEIPRES
Sbjct: 167 LDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ-KPWDKDAWEIPRES 225
Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329
++L +LG G FGEVWMG +N +T+VA+KTLKPGTMS +AFL+EA +MK L+H+KLV+LY
Sbjct: 226 IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY 285
Query: 330 AVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388
AVV+ EEPIYI+TEYM+KGSLLDFLK + G + LP+L+D +AQIA GMAY+ER NY+HR
Sbjct: 286 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR 345
Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448
DLRAAN+LV E+L+CK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKSDV
Sbjct: 346 DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV 405
Query: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE 508
WSFGILL E+ T G++PYPG N +V+ + +GYRMP CP+ L+D+M CW+++ EE
Sbjct: 406 WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE 465
Query: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531
RPTF+YLQ+ L+D++T+TE QYQ
Sbjct: 466 RPTFDYLQSVLDDFYTATEGQYQ 488
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 560 bits (1444), Expect = e-160
Identities = 267/443 (60%), Positives = 346/443 (78%), Gaps = 3/443 (0%)
Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
VALY Y+ DLSFKKGE+++++ G+WW A SL T + G+IPSNYVA ++++ E
Sbjct: 69 VALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLETE 127
Query: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
EW+F ITR+++ER LL N G FL+RESET KG++ LSV DFD G +KHYKIR
Sbjct: 128 EWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRS 187
Query: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269
LD+GG+YI+ R F + ++ +Y K ADGLC RL C + KPQ + KDAWEIPRES
Sbjct: 188 LDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ-KPWDKDAWEIPRES 246
Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329
++L +LG G FGEVWMG +N +T+VA+KTLKPGTMS +AFL+EA +MK L+H+KLV+LY
Sbjct: 247 IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY 306
Query: 330 AVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388
AVV+ EEPIYI+TEYM+KGSLLDFLK + G + LP+L+D +AQIA GMAY+ER NY+HR
Sbjct: 307 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR 366
Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448
DLRAAN+LV E+L+CK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA +G FTIKSDV
Sbjct: 367 DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV 426
Query: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE 508
WSFGILL E+ T G++PYPG N +V+ + +GYRMP CP+ L+D+M CW+++ EE
Sbjct: 427 WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE 486
Query: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531
RPTF+YLQ+ L+D++T+TE QYQ
Sbjct: 487 RPTFDYLQSVLDDFYTATEGQYQ 509
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 553 bits (1426), Expect = e-157
Identities = 278/443 (62%), Positives = 338/443 (76%), Gaps = 5/443 (1%)
Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149
VALYDY + + DL KGE+LQ++ T GDWWLA SL TG+ GY+PSN+VA +S++ E
Sbjct: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122
Query: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209
W+F R+E+ER LL N G+FL+RESET KGA+ LSV D +G +KHYKIR
Sbjct: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDV-TTQGELIKHYKIRC 181
Query: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269
LD GG+YI+ R F SLQ LV +YSK DGLC RLT C PQ A+D WEIPR+S
Sbjct: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPW-AQDEWEIPRQS 240
Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329
LRL KLG G FGEVWMG + +VAIKTLK GTMSPEAFL EA VMK L+HE+LV+LY
Sbjct: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300
Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389
AVV++EPIYIVTEYM++G LLDFLK + G L LP+L+DM+AQIA GMAY+ERMN +HRD
Sbjct: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360
Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449
LRAANILV E L CK+ADFGLAR+I D+EYTA++GAKFPIKWTAPEA +G FTIK+DVW
Sbjct: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419
Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH-DLMCQCWRKEPEE 508
SFG+LL E+ T GRVPYPGM N EV+ +ERGYRMP P CP L+ ++ +CWR PEE
Sbjct: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479
Query: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531
RPTFE+LQ+ LED++T+TE QY+
Sbjct: 480 RPTFEFLQSVLEDFYTATERQYE 502
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 468 bits (1205), Expect = e-132
Identities = 240/462 (51%), Positives = 317/462 (68%), Gaps = 21/462 (4%)
Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSL-------STGQTGYIPSNYVA 141
FVAL+DY++RT DLSF+ G++LQ+++ WW A L S GYIPSNYVA
Sbjct: 47 FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106
Query: 142 PSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN 201
S+QAE W+FG I R ++E+ LL +EN G+FL+RESE+ KG + LSV D G
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161
Query: 202 VKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC-PTSKPQTQGLAK 260
VKHY+I++LD GGF++T R F++L + V++Y+K +DGLC +L C P L+
Sbjct: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221
Query: 261 ---DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 317
D WEI R S++L +LG G FGEVW G WN TT VA+KTLKPG+M P FL+EAQ+M
Sbjct: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
Query: 318 KKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
K LRH KL+QLYAV + E+PIYI+TE M GSL ++L+ +TG + L Q VDMAAQ+ASG
Sbjct: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNE--YTARQGAKFPIKWTA 433
MAY+E NY+HRDL A N+LVGE+ + KVADFGLAR+ + DNE Y +R K P+KWTA
Sbjct: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493
PEA +F+IKSDVWSFGILL E+ T G++PY GM +V+ + + YR+P P CP+
Sbjct: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGEN 535
+++M +CW EP+ERPTFE L+ LEDYF T+ Y N
Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSYSDANN 502
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 374 bits (961), Expect = e-104
Identities = 204/445 (45%), Positives = 272/445 (61%), Gaps = 15/445 (3%)
Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQT---GYIPSNYVAPSDS 145
+V L+D++SRT+ +LSF+ G+ + E WW G GY+P NY+A ++
Sbjct: 13 YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72
Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205
+++E W+FG I+R E+ R L N G FL+R SE Y LSV D V+HY
Sbjct: 73 VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127
Query: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAK-DAWE 264
KI + G ++ F SL +LV Y+ A L H L P K + + L D WE
Sbjct: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYH--RAQSLSHGLRLAAPCRKHEPEPLPHWDDWE 185
Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ-EAQVMKKLRHE 323
PRE L KLG G FGEV+ G W +VAIK + + + LQ E Q MKKLRH+
Sbjct: 186 RPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHK 245
Query: 324 KLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382
++ LYAVVS +P+YI+TE M+KGSLL+ L+ K L + +L+D+A Q+A GM Y+E
Sbjct: 246 HILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLES 305
Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442
NY+HRDL A NILVGEN +CKV DFGLARLI+++ Y + P KWTAPEA G +
Sbjct: 306 QNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRGHY 364
Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 502
+ KSDVWSFGILL E+ ++G+VPYPGM N E +V+ GYRMPCP ECP S+H LM CW
Sbjct: 365 STKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCW 424
Query: 503 RKEPEERPTFEYLQAFLEDYFTSTE 527
++PE+RP F+ L+ L FTS E
Sbjct: 425 CRDPEQRPCFKALRERLSS-FTSYE 448
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 364 bits (935), Expect = e-100
Identities = 213/527 (40%), Positives = 305/527 (57%), Gaps = 38/527 (7%)
Query: 13 QRRRSLEPAENVHGAG-------GG----AFPASQTPSKPASADGHRGPSAAFAPAAAEP 61
QRR SL + GAG GG F + +P ++D F P
Sbjct: 12 QRRPSLPALHFIKGAGKKESSRHGGPHCNVFVEHEALQRPVASD--------FEPQGLSE 63
Query: 62 KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
+NS + + AGP FVALYD+ + + LS KGE+L+++
Sbjct: 64 A--ARWNSKENLL----AGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGE 117
Query: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
W GQ G++PSNY+ P +S++ WY G ++R +E LL + N G+FLVRESE
Sbjct: 118 WCEAQTKNGQ-GWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESE 174
Query: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
++ G +S+ +G V HY+I G Y++S ++FN+L +LV ++S ADGL
Sbjct: 175 SSPGQRSISL----RYEG-RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLI 229
Query: 242 HRLTTVCPT-SKPQTQGLAK--DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAI 297
L P +KP G++ D WE+ R + ++ KLG G +GEV+ G W + VA+
Sbjct: 230 TTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAV 289
Query: 298 KTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGE 356
KTLK TM E FL+EA VMK+++H LVQL V + EP YI+TE+M+ G+LLD+L+
Sbjct: 290 KTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLREC 349
Query: 357 TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 416
+ + L+ MA QI+S M Y+E+ N++HRDL A N LVGEN + KVADFGL+RL+
Sbjct: 350 NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTG 409
Query: 417 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 476
+ YTA GAKFPIKWTAPE+ Y +F+IKSDVW+FG+LL E+ T G PYPG+ +V +
Sbjct: 410 DTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYE 469
Query: 477 QVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523
+E+ YRM P CPE +++LM CW+ P +RP+F + E F
Sbjct: 470 LLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMF 516
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 363 bits (933), Expect = e-100
Identities = 196/450 (43%), Positives = 280/450 (62%), Gaps = 13/450 (2%)
Query: 79 AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSN 138
AGP FVALYD+ + + LS KGE+L+++ W GQ G++PSN
Sbjct: 56 AGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSN 114
Query: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198
Y+ P +S++ WY G ++R +E LL + N G+FLVRESE++ G +S+ +
Sbjct: 115 YITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISL----RYE 168
Query: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQG 257
G V HY+I G Y++S ++FN+L +LV ++S ADGL L P +KP G
Sbjct: 169 G-RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYG 227
Query: 258 LAK--DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEA 314
++ D WE+ R + ++ KLG G +GEV+ G W + VA+KTLK TM E FL+EA
Sbjct: 228 VSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEA 287
Query: 315 QVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373
VMK+++H LVQL V + EP YI+TE+M+ G+LLD+L+ + + L+ MA QI
Sbjct: 288 AVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQI 347
Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433
+S M Y+E+ N++HRDL A N LVGEN + KVADFGL+RL+ + YTA GAKFPIKWTA
Sbjct: 348 SSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTA 407
Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493
PE+ Y +F+IKSDVW+FG+LL E+ T G PYPG+ +V + +E+ YRM P CPE
Sbjct: 408 PESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEK 467
Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523
+++LM CW+ P +RP+F + E F
Sbjct: 468 VYELMRACWQWNPSDRPSFAEIHQAFETMF 497
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 359 bits (922), Expect = 3e-99
Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)
Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148
FVALYD+ + + LS KGE+L+++ + W GQ G++PSNY+ P +S++
Sbjct: 97 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 155
Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208
WY G ++R +E LL + N G+FLVRESE++ G +S+ +G V HY+I
Sbjct: 156 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 208
Query: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265
G Y+T+ ++F++L +LV ++S ADGL L P +KP G++ D WE+
Sbjct: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 268
Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324
R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA VMK+++H
Sbjct: 269 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 328
Query: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
LVQL V + E P YIVTEYM G+LLD+L+ + + L+ MA QI+S M Y+E+
Sbjct: 329 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 388
Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443
N++HRDL A N LVGEN V KVADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+
Sbjct: 389 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 448
Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503
IKSDVW+FG+LL E+ T G PYPG+ +V D +E+GYRM P CP +++LM CW+
Sbjct: 449 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 508
Query: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
P +RP+F E F + + E L
Sbjct: 509 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 359 bits (922), Expect = 3e-99
Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)
Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148
FVALYD+ + + LS KGE+L+++ + W GQ G++PSNY+ P +S++
Sbjct: 112 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 170
Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208
WY G ++R +E LL + N G+FLVRESE++ G +S+ +G V HY+I
Sbjct: 171 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 223
Query: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265
G Y+T+ ++F++L +LV ++S ADGL L P +KP G++ D WE+
Sbjct: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 283
Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324
R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA VMK+++H
Sbjct: 284 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 343
Query: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
LVQL V + E P YIVTEYM G+LLD+L+ + + L+ MA QI+S M Y+E+
Sbjct: 344 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 403
Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443
N++HRDL A N LVGEN V KVADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+
Sbjct: 404 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 463
Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503
IKSDVW+FG+LL E+ T G PYPG+ +V D +E+GYRM P CP +++LM CW+
Sbjct: 464 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 523
Query: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
P +RP+F E F + + E L
Sbjct: 524 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 556
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 359 bits (922), Expect = 3e-99
Identities = 215/523 (41%), Positives = 307/523 (58%), Gaps = 34/523 (6%)
Query: 2 GSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEP 61
GS+ ++P S RRR +PA G F + +P D P A
Sbjct: 24 GSSAARP---SGRRR--DPAGRTTETGFNIFTQHEALHRPYGCD--------VEPQALNE 70
Query: 62 KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121
+ ++S + + + P FVALYD+ + + LS KGE+L+++ +
Sbjct: 71 AI--RWSSKENLLGATESDP-----NLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGE 123
Query: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181
W GQ G++PSNY+ P +S++ WY G ++R +E LL + N G+FLVRESE
Sbjct: 124 WSEVRSKNGQ-GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESE 180
Query: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241
++ G +S+ +G V HY+I G Y+T+ ++F++L +LV ++S ADGL
Sbjct: 181 SSPGQLSISL----RYEG-RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLV 235
Query: 242 HRLTTVCPT-SKPQTQGLAK--DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAI 297
L P +KP G++ D WE+ R + ++ KLG G +GEV++G W + VA+
Sbjct: 236 TTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAV 295
Query: 298 KTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGE 356
KTLK TM E FL+EA VMK+++H LVQL V + E P YIVTEYM G+LLD+L+
Sbjct: 296 KTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLREC 355
Query: 357 TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 416
+ + L+ MA QI+S M Y+E+ N++HRDL A N LVGEN V KVADFGL+RL+
Sbjct: 356 NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTG 415
Query: 417 NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 476
+ YTA GAKFPIKWTAPE+ Y F+IKSDVW+FG+LL E+ T G PYPG+ +V D
Sbjct: 416 DTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYD 475
Query: 477 QVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTF-EYLQAF 518
+E+GYRM P CP +++LM CW+ P +RP+F E QAF
Sbjct: 476 LLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAF 518
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 359 bits (922), Expect = 3e-99
Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)
Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148
FVALYD+ + + LS KGE+L+++ + W GQ G++PSNY+ P +S++
Sbjct: 97 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 155
Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208
WY G ++R +E LL + N G+FLVRESE++ G +S+ +G V HY+I
Sbjct: 156 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 208
Query: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265
G Y+T+ ++F++L +LV ++S ADGL L P +KP G++ D WE+
Sbjct: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 268
Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324
R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA VMK+++H
Sbjct: 269 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 328
Query: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
LVQL V + E P YIVTEYM G+LLD+L+ + + L+ MA QI+S M Y+E+
Sbjct: 329 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 388
Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443
N++HRDL A N LVGEN V KVADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+
Sbjct: 389 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 448
Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503
IKSDVW+FG+LL E+ T G PYPG+ +V D +E+GYRM P CP +++LM CW+
Sbjct: 449 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 508
Query: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
P +RP+F E F + + E L
Sbjct: 509 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 541
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 359 bits (922), Expect = 3e-99
Identities = 198/453 (43%), Positives = 280/453 (61%), Gaps = 13/453 (2%)
Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148
FVALYD+ + + LS KGE+L+++ + W GQ G++PSNY+ P +S++
Sbjct: 76 FVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPVNSLEK 134
Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208
WY G ++R +E LL + N G+FLVRESE++ G +S+ +G V HY+I
Sbjct: 135 HSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISL----RYEG-RVYHYRIN 187
Query: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGLAK--DAWEI 265
G Y+T+ ++F++L +LV ++S ADGL L P +KP G++ D WE+
Sbjct: 188 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEM 247
Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324
R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA VMK+++H
Sbjct: 248 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPN 307
Query: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383
LVQL V + E P YIVTEYM G+LLD+L+ + + L+ MA QI+S M Y+E+
Sbjct: 308 LVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 367
Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443
N++HRDL A N LVGEN V KVADFGL+RL+ + YTA GAKFPIKWTAPE+ Y F+
Sbjct: 368 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 427
Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503
IKSDVW+FG+LL E+ T G PYPG+ +V D +E+GYRM P CP +++LM CW+
Sbjct: 428 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 487
Query: 504 KEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536
P +RP+F E F + + E L
Sbjct: 488 WSPADRPSFAETHQAFETMFHDSSISEEVAEEL 520
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 354 bits (908), Expect = 1e-97
Identities = 202/469 (43%), Positives = 275/469 (58%), Gaps = 20/469 (4%)
Query: 56 PAAAEPKLFGGFNSSDTVTSPQR---AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQ 112
PA EP G S D T P A P + F+ALYD+ +R +LS ++G+RL
Sbjct: 21 PAGGEPD-HGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLC 79
Query: 113 IVNNTEGDWWLAHSLSTGQ--TGYIPSNYVAPS--DSIQAEEWYFGKITRRESERLLLNA 168
+ EG ++ +GQ G +P +VA + +++ + WYF ++R ++++LLL+
Sbjct: 80 ALE--EGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSP 137
Query: 169 ENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQ 228
N G FL+R SE++ G Y LSV AK V HY++ G Y+ F L++
Sbjct: 138 PNEPGAFLIRPSESSLGGYSLSVRA--QAK---VCHYRVSMAADGSLYLQKGRLFPGLEE 192
Query: 229 LVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGT 288
L+ YY + + + L C K Q D WE P L KLG+G FGEVW G
Sbjct: 193 LLTYYKANWKLIQNPLLQPCMPQKAPRQ----DVWERPHSEFALGRKLGEGYFGEVWEGL 248
Query: 289 WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKG 347
W G+ VAIK +K M +E Q +K LRHE+L++L+AV S EP+YIVTE M KG
Sbjct: 249 WLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKG 308
Query: 348 SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVAD 407
+L FL G+ LRLP L+ A Q+A GM+Y+E VHRDL A N+LV + L CKVAD
Sbjct: 309 NLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVAD 368
Query: 408 FGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP 467
FGLARL++D+ Y+ +K P+KWTAPEAA Y F+ KSDVWSFG+LL E+ T G+ PY
Sbjct: 369 FGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYE 428
Query: 468 GMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQ 516
GM N E L Q+ RGYR+P P CP ++ LM +CWR PEERP+F L+
Sbjct: 429 GMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLR 477
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 328 bits (842), Expect = 6e-90
Identities = 179/440 (40%), Positives = 263/440 (59%), Gaps = 16/440 (3%)
Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSD--SIQA 148
ALYD+ R +L+ ++ E I+ WW A G G IPSNYV + +++
Sbjct: 89 ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147
Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN---VKHY 205
EWY ITR ++E LL E+ G F+VR+S G+Y +SV F A+ +KHY
Sbjct: 148 YEWYHRNITRNQAEHLL-RQESKEGAFIVRDSRHL-GSYTISV--FMGARRSTEAAIKHY 203
Query: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL---TTVCPTSKPQTQGLAKDA 262
+I+K DSG +Y+ R F S+ +L+ Y+ +A GL RL + + P T G + +
Sbjct: 204 QIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEK 263
Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRH 322
WEI L ++G G FG V +G W +VAIK + G+MS E F++EA+VM KL H
Sbjct: 264 WEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSH 323
Query: 323 EKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381
KLVQLY V + +P+YIVTE+M G LL++L+ GK LR L+ + I GM Y+E
Sbjct: 324 SKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLE 382
Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441
R Y+HRDL A N LV + K++DFG+ R + D+EY + GAKFPIKW+ PE L+ +
Sbjct: 383 RNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNK 442
Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501
++ KSDVWSFG+L+ E+ T+G++P+ N +V++ + G+R+ P P S++++M C
Sbjct: 443 YSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSC 502
Query: 502 WRKEPEERPTF-EYLQAFLE 520
W ++PE RPTF E L+A E
Sbjct: 503 WHEKPEGRPTFAELLRAVTE 522
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 322 bits (826), Expect = 4e-88
Identities = 174/441 (39%), Positives = 266/441 (60%), Gaps = 13/441 (2%)
Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA--PSDSIQ 147
VA+YD+++ DL ++G+ I+ + WW A G GYIPSNYV S+++
Sbjct: 185 VAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNNLD 243
Query: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV-SDFDNAKGLNVKHYK 206
EWY + R ++E+LL +E+ G F+VR+S + G Y +S+ + F +HY
Sbjct: 244 QYEWYCRNMNRSKAEQLL-RSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRHYH 301
Query: 207 IRKLDSGG--FYITSRTQFNSLQQLVAYYSKHADGLCHRL---TTVCPTSKPQTQGLAKD 261
I++ + +Y+ + F S+ +++ Y+ +A GL RL +V + P T G + +
Sbjct: 302 IKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYE 361
Query: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 321
WEI L +LG G FG V +G W +VAIK ++ G M E F++EA+VM KL
Sbjct: 362 KWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLT 421
Query: 322 HEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380
H KLVQLY V +++ PIYIVTE+M +G LL+FL+ G + R L+ M + GM Y+
Sbjct: 422 HPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGMEYL 480
Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440
ER +++HRDL A N LV E V KV+DFG+AR + D++YT+ GAKFP+KW PE Y
Sbjct: 481 ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS 540
Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500
RF+ KSDVWSFG+L+ E+ T+GR+P+ N EV+ V RG+R+ P ++++M +
Sbjct: 541 RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR 600
Query: 501 CWRKEPEERPTFEYLQAFLED 521
CW+++PE RP+FE L +++
Sbjct: 601 CWQEKPEGRPSFEDLLRTIDE 621
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 318 bits (816), Expect = 6e-87
Identities = 184/496 (37%), Positives = 279/496 (56%), Gaps = 32/496 (6%)
Query: 40 KPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTT-----FVALYD 94
KP S+ HR P E ++ + P P A V+T VALYD
Sbjct: 176 KPGSS--HRKTKKPLPPTPEEDQI---------LKKPLPPEPAAAPVSTSELKKVVALYD 224
Query: 95 YESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS-DSIQAEEWYF 153
Y DL +KG+ I+ + WW A GQ GYIPSNYV + DSI+ EWY
Sbjct: 225 YMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEMYEWYS 283
Query: 154 GKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV--SDFDNAKGLNVKHYKIRKLD 211
+TR ++E+LL E G F+VR+S G Y +SV + +G+ ++HY +
Sbjct: 284 KHMTRSQAEQLL-KQEGKEGGFIVRDSSKA-GKYTVSVFAKSTGDPQGV-IRHYVVCSTP 340
Query: 212 SGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSK-----PQTQGLAKDAWEIP 266
+Y+ + F+++ +L+ Y+ ++ GL RL P S+ P T GL +WEI
Sbjct: 341 QSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKY--PVSQQNKNAPSTAGLGYGSWEID 398
Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326
+ L +LG G FG V G W G VAIK +K G+MS + F++EA+VM L HEKLV
Sbjct: 399 PKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLV 458
Query: 327 QLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385
QLY V +++ PI+I+TEYM+ G LL++L+ E + QL++M + M Y+E +
Sbjct: 459 QLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYLESKQF 517
Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445
+HRDL A N LV + V KV+DFGL+R + D+EYT+ G+KFP++W+ PE +Y +F+ K
Sbjct: 518 LHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSK 577
Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505
SD+W+FG+L+ E+ + G++PY N E + + +G R+ P E ++ +M CW ++
Sbjct: 578 SDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEK 637
Query: 506 PEERPTFEYLQAFLED 521
+ERPTF+ L + + D
Sbjct: 638 ADERPTFKILLSNILD 653
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 305 bits (782), Expect = 5e-83
Identities = 166/439 (37%), Positives = 255/439 (58%), Gaps = 14/439 (3%)
Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS--D 144
T +ALYDY++ +L+ ++ E +++++E WW + G GY+PS+Y+ +
Sbjct: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRN-GHEGYVPSSYLVEKSPN 232
Query: 145 SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN--V 202
+++ EWY I+R ++E+LLL+ G F+VR+S T G Y +SV N +
Sbjct: 233 NLETYEWYNKSISRDKAEKLLLDT-GKEGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290
Query: 203 KHYKIRKLDSGG--FYITSRTQFNSLQQLVAYYSKHADGLCHRLT-TVC--PTSKPQTQG 257
KHY I++ + +Y+ + F+S+ L+ Y+ + GL RL VC P T G
Sbjct: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350
Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 317
L W I L ++G G FG V +G W +VAIKT++ G MS E F++EA+VM
Sbjct: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410
Query: 318 KKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
KL H KLVQLY V E+ PI +V E+M G L D+L+ + G + L+ M + G
Sbjct: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAA-ETLLGMCLDVCEG 469
Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436
MAY+E +HRDL A N LVGEN V KV+DFG+ R + D++YT+ G KFP+KW +PE
Sbjct: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529
Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496
+ R++ KSDVWSFG+L+ E+ ++G++PY N EV++ + G+R+ P ++
Sbjct: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589
Query: 497 LMCQCWRKEPEERPTFEYL 515
+M CW++ PE+RP F L
Sbjct: 590 IMNHCWKERPEDRPAFSRL 608
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 294 bits (753), Expect = 1e-79
Identities = 179/444 (40%), Positives = 250/444 (56%), Gaps = 24/444 (5%)
Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI 146
T +A Y++ E DL F KG+ L IV T+ W G+ G IP+NYV + +
Sbjct: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV 71
Query: 147 QAEE------WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL 200
+A W+ GKITR ++ERLL E G FLVRES G Y L VS G
Sbjct: 72 KAGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVS----CDG- 124
Query: 201 NVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT--VCPTSKPQTQGL 258
V+HY+I + I F +L QLV +Y+ ADGLC RL V +
Sbjct: 125 KVEHYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEF 183
Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318
+ W + + L+L +G+G FG+V +G + G +VA+K +K + +AFL EA VM
Sbjct: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMT 241
Query: 319 KLRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
+LRH LVQL V+ EE +YIVTEYM+KGSL+D+L+ L L+ + +
Sbjct: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301
Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436
M Y+E N+VHRDL A N+LV E+ V KV+DFGL + + T K P+KWTAPEA
Sbjct: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEA 357
Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496
+F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP ++++
Sbjct: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE 417
Query: 497 LMCQCWRKEPEERPTFEYLQAFLE 520
+M CW + RP+F L+ LE
Sbjct: 418 VMKNCWHLDAAMRPSFLQLREQLE 441
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,964,093
Number of Sequences: 37866
Number of extensions: 1050091
Number of successful extensions: 5912
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 772
Number of HSP's successfully gapped in prelim test: 319
Number of HSP's that attempted gapping in prelim test: 3417
Number of HSP's gapped (non-prelim): 1434
length of query: 536
length of database: 18,247,518
effective HSP length: 107
effective length of query: 429
effective length of database: 14,195,856
effective search space: 6090022224
effective search space used: 6090022224
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.