Search of human proteins with 4885563

Search of human proteins with 4885563

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4885563 protein kinase C, epsilon [Homo sapiens]
         (737 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4885563 protein kinase C, epsilon [Homo sapiens]                  1524   0.0  
gi|28557781 protein kinase C, eta [Homo sapiens]                      917   0.0  
gi|4506067 protein kinase C, alpha [Homo sapiens]                     590   e-168
gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]           589   e-168
gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]           585   e-167
gi|47157325 protein kinase C, delta [Homo sapiens]                    569   e-162
gi|31377782 protein kinase C, delta [Homo sapiens]                    569   e-162
gi|5453976 protein kinase C, theta [Homo sapiens]                     560   e-159
gi|13384594 protein kinase C, gamma [Homo sapiens]                    409   e-114
gi|133908623 protein kinase C, iota [Homo sapiens]                    407   e-113
gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]           399   e-111
gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]           374   e-103
gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]           374   e-103
gi|5453974 protein kinase N2 [Homo sapiens]                           351   2e-96
gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]                       333   3e-91
gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]                      333   3e-91
gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]                324   2e-88
gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]                324   2e-88
gi|62241015 AKT1 kinase [Homo sapiens]                                322   8e-88
gi|62241013 AKT1 kinase [Homo sapiens]                                322   8e-88
gi|62241011 AKT1 kinase [Homo sapiens]                                322   8e-88
gi|4502023 AKT2 kinase [Homo sapiens]                                 322   1e-87
gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [H...   296   5e-80
gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4 [...   296   5e-80
gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3 [...   296   5e-80
gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2 [...   296   5e-80
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   295   1e-79
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H...   295   1e-79
gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta...   293   4e-79
gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alph...   292   7e-79

>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score = 1524 bits (3945), Expect = 0.0
 Identities = 737/737 (100%), Positives = 737/737 (100%)

Query: 1   MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT 60
           MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT
Sbjct: 1   MVVFNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKT 60

Query: 61  NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE 120
           NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE
Sbjct: 61  NSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGSRHFEDWIDLE 120

Query: 121 PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP 180
           PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP
Sbjct: 121 PEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQP 180

Query: 181 TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN 240
           TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN
Sbjct: 181 TYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVN 240

Query: 241 MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA 300
           MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA
Sbjct: 241 MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA 300

Query: 301 KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE 360
           KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE
Sbjct: 301 KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE 360

Query: 361 NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG 420
           NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG
Sbjct: 361 NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG 420

Query: 421 KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD 480
           KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD
Sbjct: 421 KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD 480

Query: 481 RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL 540
           RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL
Sbjct: 481 RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL 540

Query: 541 DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM 600
           DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM
Sbjct: 541 DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM 600

Query: 601 MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED 660
           MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED
Sbjct: 601 MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED 660

Query: 661 AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI 720
           AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI
Sbjct: 661 AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI 720

Query: 721 NQEEFKGFSYFGEDLMP 737
           NQEEFKGFSYFGEDLMP
Sbjct: 721 NQEEFKGFSYFGEDLMP 737


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score =  917 bits (2371), Expect = 0.0
 Identities = 451/737 (61%), Positives = 552/737 (74%), Gaps = 64/737 (8%)

Query: 4   FNGLLKIKICEAVSLKPTAWSLRHAVGPRPQTFLLDPYIALNVDDSRIGQTATKQKTNSP 63
           FNG L+++I EAV L+PT WSLRH++  +    LLDPY+ ++VD  R+GQT+TKQKTN P
Sbjct: 8   FNGYLRVRIGEAVGLQPTRWSLRHSLFKKGHQ-LLDPYLTVSVDQVRVGQTSTKQKTNKP 66

Query: 64  AWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQN--GSRHFEDWIDLEP 121
            +++EF  +V +G  +ELAVFH+ P+GYD FVANCT+QF+ELL+    S  FE W+DLEP
Sbjct: 67  TYNEEFCANVTDGGHLELAVFHETPLGYDHFVANCTLQFQELLRTTGASDTFEGWVDLEP 126

Query: 122 EGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRRRVHQVNGHKFMATYLRQPT 181
           EG+V+V+I L+GS  EA    + R+F+   R  KRQ A+RRRVHQ+NGHKFMATYLRQPT
Sbjct: 127 EGKVFVVITLTGSFTEATLQRD-RIFKHFTR--KRQRAMRRRVHQINGHKFMATYLRQPT 183

Query: 182 YCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPD-QVGSQRFSVN 240
           YCSHCR+FIWGV GKQGYQCQVCTCVVHKRCH LI+T C         D ++  QRF +N
Sbjct: 184 YCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKVDSKIAEQRFGIN 243

Query: 241 MPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIA 300
           +PHKF IHNYKVPTFCDHCGSLLWG++RQGLQCK+CKMNVH RC+ NVAPNCGV+A  +A
Sbjct: 244 IPHKFSIHNYKVPTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNCGVNAVELA 303

Query: 301 KVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELE 360
           K LA +G+ P  I                       SP+ +  S+S              
Sbjct: 304 KTLAGMGLQPGNI-----------------------SPTSKLVSRS-------------- 326

Query: 361 NNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFG 420
                  +   +G+E    SS +G       NG +    + RLG+D F FI+VLGKGSFG
Sbjct: 327 -------TLRRQGKE----SSKEG-------NG-IGVNSSNRLGIDNFEFIRVLGKGSFG 367

Query: 421 KVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKD 480
           KVMLA +K   ++YAVKVLKKDVILQDDDV+CTMTEKRIL+LAR HP+LTQL+CCFQT D
Sbjct: 368 KVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPD 427

Query: 481 RLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL 540
           RLFFVME+VNGGDLMF IQ+SR+FDE R+RFYAAE+ SALMFLH  G+IYRDLKLDN+LL
Sbjct: 428 RLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLL 487

Query: 541 DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEM 600
           D EGHCKLADFGMCKEGI NGVTT TFCGTPDYIAPEILQE+ YGP+VDWWA+GVL+YEM
Sbjct: 488 DHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEM 547

Query: 601 MAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGED 660
           + G  PFEA+NEDDLFE+IL+D+V+YP WL ++A  ILK+FMTKNP  RLG + +Q GE 
Sbjct: 548 LCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSL-TQGGEH 606

Query: 661 AIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQI 720
           AI +HPFFKEIDW  L  ++I+PPF+PRIK++ DV+NFD DF +EEPVLT +DE  +  I
Sbjct: 607 AILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMI 666

Query: 721 NQEEFKGFSYFGEDLMP 737
           NQ+EF+ FSY   +L P
Sbjct: 667 NQDEFRNFSYVSPELQP 683


>gi|4506067 protein kinase C, alpha [Homo sapiens]
          Length = 672

 Score =  590 bits (1522), Expect = e-168
 Identities = 310/652 (47%), Positives = 409/652 (62%), Gaps = 92/652 (14%)

Query: 156 RQGAVRRR-VHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHE 214
           R+GA+R++ VH+V  HKF+A + +QPT+CSHC DFIWG  GKQG+QCQVC  VVHKRCHE
Sbjct: 22  RKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWG-FGKQGFQCQVCCFVVHKRCHE 80

Query: 215 LIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCK 274
            +   C G  K    D   S+       HKF IH Y  PTFCDHCGSLL+GL+ QG++C 
Sbjct: 81  FVTFSCPGADKGPDTDDPRSK-------HKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCD 133

Query: 275 VCKMNVHRRCETNVAPNCGVD---------------------------------ARGIAK 301
            C MNVH++C  NV   CG+D                                   G++ 
Sbjct: 134 TCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSD 193

Query: 302 VLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSS----PSEEDRSKSAPTSPCDQEIK 357
               L + PD   N  +++ K I    +PQ     +    PS++DR  S      D+  +
Sbjct: 194 PYVKLKLIPDP-KNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTR 252

Query: 358 ELENNIRKALSF--------------------------------------DNRGEEHRAA 379
              N+   +LSF                                      + R +  +A 
Sbjct: 253 ---NDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAK 309

Query: 380 SSPDG-QLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKV 438
             P G +++SP E+ +       R+ L +FNF+ VLGKGSFGKVMLA+ KG +E+YA+K+
Sbjct: 310 LGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKI 369

Query: 439 LKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQI 498
           LKKDV++QDDDV+CTM EKR+LAL  K P+LTQL+ CFQT DRL+FVMEYVNGGDLM+ I
Sbjct: 370 LKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHI 429

Query: 499 QRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGI 558
           Q+  KF EP++ FYAAE++  L FLH+ G+IYRDLKLDN++LD+EGH K+ADFGMCKE +
Sbjct: 430 QQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHM 489

Query: 559 LNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFES 618
           ++GVTT TFCGTPDYIAPEI+    YG SVDWWA GVL+YEM+AGQPPF+ ++ED+LF+S
Sbjct: 490 MDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQS 549

Query: 619 ILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQ 678
           I+  +V YP  LSKEAVSI K  MTK+P KRLGC     GE  +++H FF+ IDW  LE 
Sbjct: 550 IMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGC--GPEGERDVREHAFFRRIDWEKLEN 607

Query: 679 KKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSY 730
           ++I+PPFKP++  K    NFD+ FTR +PVLT  D+ ++  I+Q +F+GFSY
Sbjct: 608 REIQPPFKPKVCGK-GAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSY 658


>gi|47157322 protein kinase C, beta isoform 1 [Homo sapiens]
          Length = 671

 Score =  589 bits (1519), Expect = e-168
 Identities = 313/674 (46%), Positives = 401/674 (59%), Gaps = 93/674 (13%)

Query: 134 SSGEAPKDNEERVFRERMRPRKRQGAVRRR-VHQVNGHKFMATYLRQPTYCSHCRDFIWG 192
           ++G  P + EE   R       R+GA+R++ VH+V  HKF A + +QPT+CSHC DFIWG
Sbjct: 5   AAGPPPSEGEESTVRFA-----RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWG 59

Query: 193 VIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKV 252
             GKQG+QCQVC  VVHKRCHE +   C G  K    D   S+       HKF IH Y  
Sbjct: 60  -FGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSK-------HKFKIHTYSS 111

Query: 253 PTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCG------------------- 293
           PTFCDHCGSLL+GL+ QG++C  C MNVH+RC  NV   CG                   
Sbjct: 112 PTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRD 171

Query: 294 --------------VDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESP-QPASGSSP 338
                         +D  G++     L + PD  + S Q+ K +                
Sbjct: 172 VLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231

Query: 339 SEEDRSKSAPTSPCDQEIKELENNIRKALSF------------------DNRGEEHRAAS 380
            E D+ +       D ++    N+   +LSF                     GE      
Sbjct: 232 KESDKDRRLSVEIWDWDLTS-RNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPV 290

Query: 381 SPDG-----QLMSPGENGEVRQ-------------------GQAKRLGLDEFNFIKVLGK 416
            P+G     +L    E  ++ Q                   G   R+ L +FNF+ VLGK
Sbjct: 291 PPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGK 350

Query: 417 GSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCF 476
           GSFGKVML+E KG DE+YAVK+LKKDV++QDDDV+CTM EKR+LAL  K P+LTQL+ CF
Sbjct: 351 GSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCF 410

Query: 477 QTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLD 536
           QT DRL+FVMEYVNGGDLM+ IQ+  +F EP + FYAAE+   L FL   G+IYRDLKLD
Sbjct: 411 QTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLD 470

Query: 537 NILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVL 596
           N++LD+EGH K+ADFGMCKE I +GVTT TFCGTPDYIAPEI+    YG SVDWWA GVL
Sbjct: 471 NVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL 530

Query: 597 MYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQ 656
           +YEM+AGQ PFE ++ED+LF+SI+  +V YP  +SKEAV+I K  MTK+P KRLGC    
Sbjct: 531 LYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGC--GP 588

Query: 657 NGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAI 716
            GE  IK+H FF+ IDW  LE+K+I+PP+KP+ + KRD +NFD++FTR+   LT  D+  
Sbjct: 589 EGERDIKEHAFFRYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLF 648

Query: 717 VKQINQEEFKGFSY 730
           +  ++Q EF GFSY
Sbjct: 649 IMNLDQNEFAGFSY 662


>gi|20127450 protein kinase C, beta isoform 2 [Homo sapiens]
          Length = 673

 Score =  585 bits (1508), Expect = e-167
 Identities = 313/680 (46%), Positives = 403/680 (59%), Gaps = 94/680 (13%)

Query: 134 SSGEAPKDNEERVFRERMRPRKRQGAVRRR-VHQVNGHKFMATYLRQPTYCSHCRDFIWG 192
           ++G  P + EE   R       R+GA+R++ VH+V  HKF A + +QPT+CSHC DFIWG
Sbjct: 5   AAGPPPSEGEESTVRFA-----RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWG 59

Query: 193 VIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKV 252
             GKQG+QCQVC  VVHKRCHE +   C G  K    D   S+       HKF IH Y  
Sbjct: 60  -FGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSK-------HKFKIHTYSS 111

Query: 253 PTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCG------------------- 293
           PTFCDHCGSLL+GL+ QG++C  C MNVH+RC  NV   CG                   
Sbjct: 112 PTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRD 171

Query: 294 --------------VDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESP-QPASGSSP 338
                         +D  G++     L + PD  + S Q+ K +                
Sbjct: 172 VLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQL 231

Query: 339 SEEDRSKSAPTSPCDQEIKELENNIRKALSF------------------DNRGEEHRAAS 380
            E D+ +       D ++    N+   +LSF                     GE      
Sbjct: 232 KESDKDRRLSVEIWDWDLTS-RNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPV 290

Query: 381 SPDG-----QLMSPGENGEVRQ-------------------GQAKRLGLDEFNFIKVLGK 416
            P+G     +L    E  ++ Q                   G   R+ L +FNF+ VLGK
Sbjct: 291 PPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGK 350

Query: 417 GSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCF 476
           GSFGKVML+E KG DE+YAVK+LKKDV++QDDDV+CTM EKR+LAL  K P+LTQL+ CF
Sbjct: 351 GSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCF 410

Query: 477 QTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLD 536
           QT DRL+FVMEYVNGGDLM+ IQ+  +F EP + FYAAE+   L FL   G+IYRDLKLD
Sbjct: 411 QTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLD 470

Query: 537 NILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVL 596
           N++LD+EGH K+ADFGMCKE I +GVTT TFCGTPDYIAPEI+    YG SVDWWA GVL
Sbjct: 471 NVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVL 530

Query: 597 MYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQ 656
           +YEM+AGQ PFE ++ED+LF+SI+  +V YP  +SKEAV+I K  MTK+P KRLGC    
Sbjct: 531 LYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGC--GP 588

Query: 657 NGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAI 716
            GE  IK+H FF+ IDW  LE+K+I+PP+KP+    R+  NFD+ FTR  PVLT  D+ +
Sbjct: 589 EGERDIKEHAFFRYIDWEKLERKEIQPPYKPK-ACGRNAENFDRFFTRHPPVLTPPDQEV 647

Query: 717 VKQINQEEFKGFSYFGEDLM 736
           ++ I+Q EF+GFS+   + +
Sbjct: 648 IRNIDQSEFEGFSFVNSEFL 667


>gi|47157325 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  569 bits (1467), Expect = e-162
 Identities = 287/681 (42%), Positives = 413/681 (60%), Gaps = 58/681 (8%)

Query: 52  GQTATKQK-TNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGS 110
           G+T  ++K T  P W   F   +  GR I++ +   A     +     ++  E   +N  
Sbjct: 41  GKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNG 100

Query: 111 RHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRR-RVHQVNG 169
           +  E W+DL+P+ +V + +       +  K +       +     R+GA+++ ++H +  
Sbjct: 101 KA-EFWLDLQPQAKVLMSVQYFLEDVDC-KQSMRSEDEAKFPTMNRRGAIKQAKIHYIKN 158

Query: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETP 229
           H+F+AT+  QPT+CS C+DF+WG + KQGY+C+ C   +HK+C + II +C G       
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWG-LNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRD 217

Query: 230 DQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVA 289
                +RF+++MPH+F +HNY  PTFCDHCGSLLWGL++QGL+C+ C MNVH +C   VA
Sbjct: 218 TIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVA 277

Query: 290 PNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPT 349
             CG++ + +A+ L       +++T    RR                     D + S P 
Sbjct: 278 NLCGINQKLLAEAL-------NQVTQRASRRS--------------------DSASSEPV 310

Query: 350 SPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFN 409
                                 +G E +   + +    + G  G++ +G +K   ++ F 
Sbjct: 311 GIY-------------------QGFEKKTGVAGEDMQDNSGTYGKIWEGSSK-CNINNFI 350

Query: 410 FIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYL 469
           F KVLGKGSFGKV+L ELKG+ E +A+K LKKDV+L DDDV+CTM EKR+L LA ++P+L
Sbjct: 351 FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFL 410

Query: 470 TQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVI 529
           T L C FQTKD LFFVME++NGGDLM+ IQ   +F+  R+ FYAAE+   L FLH  G+I
Sbjct: 411 THLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGII 470

Query: 530 YRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVD 589
           YRDLKLDN+LLD +GH K+ADFGMCKE I      +TFCGTPDYIAPEILQ L+Y  SVD
Sbjct: 471 YRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVD 530

Query: 590 WWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR 649
           WW+ GVL+YEM+ GQ PF  D+ED+LFESI  D   YP W++KE+  IL+    + P KR
Sbjct: 531 WWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKR 590

Query: 650 LGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVL 709
           LG   +      IK HPFFK I+W LLE+++++PPF+P++K+ RD +NFDQ+F  E+  L
Sbjct: 591 LGVTGN------IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARL 644

Query: 710 TLVDEAIVKQINQEEFKGFSY 730
           +  D+ ++  ++Q  F GFS+
Sbjct: 645 SYSDKNLIDSMDQSAFAGFSF 665


>gi|31377782 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score =  569 bits (1467), Expect = e-162
 Identities = 287/681 (42%), Positives = 413/681 (60%), Gaps = 58/681 (8%)

Query: 52  GQTATKQK-TNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQFEELLQNGS 110
           G+T  ++K T  P W   F   +  GR I++ +   A     +     ++  E   +N  
Sbjct: 41  GKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNG 100

Query: 111 RHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAVRR-RVHQVNG 169
           +  E W+DL+P+ +V + +       +  K +       +     R+GA+++ ++H +  
Sbjct: 101 KA-EFWLDLQPQAKVLMSVQYFLEDVDC-KQSMRSEDEAKFPTMNRRGAIKQAKIHYIKN 158

Query: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETP 229
           H+F+AT+  QPT+CS C+DF+WG + KQGY+C+ C   +HK+C + II +C G       
Sbjct: 159 HEFIATFFGQPTFCSVCKDFVWG-LNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRD 217

Query: 230 DQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVA 289
                +RF+++MPH+F +HNY  PTFCDHCGSLLWGL++QGL+C+ C MNVH +C   VA
Sbjct: 218 TIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVA 277

Query: 290 PNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPT 349
             CG++ + +A+ L       +++T    RR                     D + S P 
Sbjct: 278 NLCGINQKLLAEAL-------NQVTQRASRRS--------------------DSASSEPV 310

Query: 350 SPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFN 409
                                 +G E +   + +    + G  G++ +G +K   ++ F 
Sbjct: 311 GIY-------------------QGFEKKTGVAGEDMQDNSGTYGKIWEGSSK-CNINNFI 350

Query: 410 FIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYL 469
           F KVLGKGSFGKV+L ELKG+ E +A+K LKKDV+L DDDV+CTM EKR+L LA ++P+L
Sbjct: 351 FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFL 410

Query: 470 TQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVI 529
           T L C FQTKD LFFVME++NGGDLM+ IQ   +F+  R+ FYAAE+   L FLH  G+I
Sbjct: 411 THLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGII 470

Query: 530 YRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVD 589
           YRDLKLDN+LLD +GH K+ADFGMCKE I      +TFCGTPDYIAPEILQ L+Y  SVD
Sbjct: 471 YRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVD 530

Query: 590 WWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKR 649
           WW+ GVL+YEM+ GQ PF  D+ED+LFESI  D   YP W++KE+  IL+    + P KR
Sbjct: 531 WWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKR 590

Query: 650 LGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVL 709
           LG   +      IK HPFFK I+W LLE+++++PPF+P++K+ RD +NFDQ+F  E+  L
Sbjct: 591 LGVTGN------IKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARL 644

Query: 710 TLVDEAIVKQINQEEFKGFSY 730
           +  D+ ++  ++Q  F GFS+
Sbjct: 645 SYSDKNLIDSMDQSAFAGFSF 665


>gi|5453976 protein kinase C, theta [Homo sapiens]
          Length = 706

 Score =  560 bits (1444), Expect = e-159
 Identities = 297/706 (42%), Positives = 427/706 (60%), Gaps = 47/706 (6%)

Query: 38  LDPYIALNVDD---SRIGQTATKQK-TNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDD 93
           ++PY A+ V +   S  GQ   ++K T  P W   F   +  GR +++ V         D
Sbjct: 25  VNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTFDAHINKGRVMQIIVKGKNV----D 80

Query: 94  FVANCTIQFEELLQNGSRH---FEDWIDLEPEGRVYV----IIDLSGSSGEAPKDNEERV 146
            ++  T++   L +   ++    E W++L+P+GR+ +     +++S +     KD  E  
Sbjct: 81  LISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEMSDT-----KDMNEFE 135

Query: 147 FRERMRPRKRQGAVRR-RVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCT 205
                   +R+GA+++ +VH V  H+F AT+  QPT+CS C +F+WG + KQGYQC+ C 
Sbjct: 136 TEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFVWG-LNKQGYQCRQCN 194

Query: 206 CVVHKRCHELIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWG 265
             +HK+C + +I KC G            +RF ++MPH+F ++NYK PTFC+HCG+LLWG
Sbjct: 195 AAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWG 254

Query: 266 LLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVLADLGVTPDKITNSGQRRKKLIA 325
           L RQGL+C  C MNVH RC+T VA  CG++ + +A+ LA +  T          +     
Sbjct: 255 LARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREG 314

Query: 326 GAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEE-HRAASSPDG 384
             E   P S  +   E R    PT P  +E         + +S+++  +E  +    P+ 
Sbjct: 315 PVEIGLPCSIKN---EARPPCLPT-PGKRE--------PQGISWESPLDEVDKMCHLPEP 362

Query: 385 QLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVI 444
           +L       + R     +L +++F   K+LGKGSFGKV LAE K  ++ +A+K LKKDV+
Sbjct: 363 EL------NKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVV 416

Query: 445 LQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKF 504
           L DDDV+CTM EKR+L+LA +HP+LT ++C FQTK+ LFFVMEY+NGGDLM+ IQ   KF
Sbjct: 417 LMDDDVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKF 476

Query: 505 DEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTT 564
           D  R+ FYAAE+   L FLH  G++YRDLKLDNILLD +GH K+ADFGMCKE +L    T
Sbjct: 477 DLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKT 536

Query: 565 TTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDV 624
            TFCGTPDYIAPEIL   +Y  SVDWW+ GVL+YEM+ GQ PF   +E++LF SI  D+ 
Sbjct: 537 NTFCGTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNP 596

Query: 625 LYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPP 684
            YP WL KEA  +L     + P KRLG          I+QHP F+EI+W  LE+K+I PP
Sbjct: 597 FYPRWLEKEAKDLLVKLFVREPEKRLGV------RGDIRQHPLFREINWEELERKEIDPP 650

Query: 685 FKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSY 730
           F+P++K+  D +NFD++F  E+P L+  D A++  ++Q  F+ FS+
Sbjct: 651 FRPKVKSPFDCSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSF 696


>gi|13384594 protein kinase C, gamma [Homo sapiens]
          Length = 697

 Score =  409 bits (1051), Expect = e-114
 Identities = 197/340 (57%), Positives = 252/340 (74%), Gaps = 8/340 (2%)

Query: 402 RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILA 461
           RL + +F+F+ VLGKGSFGKVMLAE +G DE+YA+K+LKKDVI+QDDDVDCT+ EKR+LA
Sbjct: 345 RLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLA 404

Query: 462 LARKHP-----YLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEV 516
           L  + P     +LTQL+  FQT DRL+FVMEYV GGDLM+ IQ+  KF EP + FYAAE+
Sbjct: 405 LGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEI 464

Query: 517 TSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAP 576
              L FLH  G+IYRDLKLDN++LDAEGH K+ DFGMCKE +  G TT TFCGTPDYIAP
Sbjct: 465 AIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAP 524

Query: 577 EILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVS 636
           EI+    YG SVDWW+ GVL+YEM+AGQPPF+ ++E++LF++I+   V YP  LS+EAV+
Sbjct: 525 EIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVA 584

Query: 637 ILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVN 696
           I K F+TK+P KRLG  +  +GE  I+ H FF+ IDW  LE+ +I PPF+PR    R   
Sbjct: 585 ICKGFLTKHPGKRLG--SGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPR-PCGRSGE 641

Query: 697 NFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLM 736
           NFD+ FTR  P LT  D  ++  I+Q +F+GF+Y   D +
Sbjct: 642 NFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFV 681



 Score =  173 bits (438), Expect = 6e-43
 Identities = 79/141 (56%), Positives = 99/141 (70%), Gaps = 9/141 (6%)

Query: 156 RQGAVRRRV-HQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHE 214
           R+GA+R++V H+V  HKF A + +QPT+CSHC DFIWG IGKQG QCQVC+ VVH+RCHE
Sbjct: 21  RKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWG-IGKQGLQCQVCSFVVHRRCHE 79

Query: 215 LIITKCAGLKKQETPDQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCK 274
            +  +C G  K       G Q       HKF +H+Y  PTFCDHCGSLL+GL+ QG++C 
Sbjct: 80  FVTFECPGAGK-------GPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCS 132

Query: 275 VCKMNVHRRCETNVAPNCGVD 295
            C+MNVHRRC  +V   CGVD
Sbjct: 133 CCEMNVHRRCVRSVPSLCGVD 153



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 27/56 (48%), Positives = 33/56 (58%)

Query: 243 HKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARG 298
           HKF    +K PTFC HC   +WG+ +QGLQC+VC   VHRRC   V   C    +G
Sbjct: 36  HKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKG 91


>gi|133908623 protein kinase C, iota [Homo sapiens]
          Length = 596

 Score =  407 bits (1047), Expect = e-113
 Identities = 222/503 (44%), Positives = 298/503 (59%), Gaps = 62/503 (12%)

Query: 243 HKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKV 302
           H F    +     C  C   +WGL RQG +C  CK+ VH++C   V   CG         
Sbjct: 141 HTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKCHKLVTIECG--------- 191

Query: 303 LADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENN 362
                            R  L    E   P   SS   +      P +P   E       
Sbjct: 192 -----------------RHSL--PQEPVMPMDQSSMHSDHAQTVIPYNPSSHE------- 225

Query: 363 IRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKV 422
                S D  GEE  A        M+  E+G+     +  LGL +F+ ++V+G+GS+ KV
Sbjct: 226 -----SLDQVGEEKEA--------MNTRESGKA----SSSLGLQDFDLLRVIGRGSYAKV 268

Query: 423 MLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRL 482
           +L  LK  D +YA+KV+KK+++  D+D+D   TEK +   A  HP+L  L+ CFQT+ RL
Sbjct: 269 LLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRL 328

Query: 483 FFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDA 542
           FFV+EYVNGGDLMF +QR RK  E  +RFY+AE++ AL +LH+ G+IYRDLKLDN+LLD+
Sbjct: 329 FFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDS 388

Query: 543 EGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMA 602
           EGH KL D+GMCKEG+  G TT+TFCGTP+YIAPEIL+  +YG SVDWWALGVLM+EMMA
Sbjct: 389 EGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMA 448

Query: 603 GQPPFE----ADN-----EDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCV 653
           G+ PF+    +DN     ED LF+ IL   +  P  LS +A S+LK+F+ K+P +RLGC 
Sbjct: 449 GRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGC- 507

Query: 654 ASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVD 713
             Q G   I+ HPFF+ +DW ++EQK++ PPFKP I  +  ++NFD  FT E   LT  D
Sbjct: 508 HPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFGLDNFDSQFTNEPVQLTPDD 567

Query: 714 EAIVKQINQEEFKGFSYFGEDLM 736
           + IV++I+Q EF+GF Y    LM
Sbjct: 568 DDIVRKIDQSEFEGFEYINPLLM 590



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 29/66 (43%), Positives = 44/66 (66%), Gaps = 2/66 (3%)

Query: 156 RQGAVR-RRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHE 214
           R+GA R R+++  NGH F A    +  +C+ C D IWG +G+QGY+C  C  +VHK+CH+
Sbjct: 126 RRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWG-LGRQGYKCINCKLLVHKKCHK 184

Query: 215 LIITKC 220
           L+  +C
Sbjct: 185 LVTIEC 190


>gi|52486327 protein kinase C, zeta isoform 1 [Homo sapiens]
          Length = 592

 Score =  399 bits (1024), Expect = e-111
 Identities = 217/501 (43%), Positives = 299/501 (59%), Gaps = 52/501 (10%)

Query: 243 HKFGIHNYKVPTFCDHCGSLLWGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKV 302
           H F    +    +C  C   +WGL RQG +C  CK+ VH+RC   V   C          
Sbjct: 131 HLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTC---------- 180

Query: 303 LADLGVTPDKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPTSPCDQEIKELENN 362
                            RK +    +S  P+    P  +D+++ A          +L + 
Sbjct: 181 -----------------RKHM----DSVMPSQ--EPPVDDKNEDA----------DLPSE 207

Query: 363 IRKALSFDNRGEEHRAASSPDGQLMSPGENGEVRQGQAKRLGLDEFNFIKVLGKGSFGKV 422
               +++ +   +H +    D + + P  +G      ++ LGL +F+ I+V+G+GS+ KV
Sbjct: 208 ETDGIAYISSSRKHDSIKD-DSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKV 266

Query: 423 MLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRL 482
           +L  LK  D++YA+KV+KK+++  D+D+D   TEK +   A  +P+L  L+ CFQT  RL
Sbjct: 267 LLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRL 326

Query: 483 FFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDA 542
           F V+EYVNGGDLMF +QR RK  E  +RFYAAE+  AL FLH+ G+IYRDLKLDN+LLDA
Sbjct: 327 FLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDA 386

Query: 543 EGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMA 602
           +GH KL D+GMCKEG+  G TT+TFCGTP+YIAPEIL+  EYG SVDWWALGVLM+EMMA
Sbjct: 387 DGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMA 446

Query: 603 GQPPFE--ADN-----EDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVAS 655
           G+ PF+   DN     ED LF+ IL   +  P +LS +A  +LK F+ K+P +RLGC   
Sbjct: 447 GRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGC-RP 505

Query: 656 QNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEA 715
           Q G   IK H FF+ IDW LLE+K+  PPF+P+I     ++NFD  FT E   LT  DE 
Sbjct: 506 QTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDED 565

Query: 716 IVKQINQEEFKGFSYFGEDLM 736
            +K+I+Q EF+GF Y    L+
Sbjct: 566 AIKRIDQSEFEGFEYINPLLL 586



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 31/77 (40%), Positives = 43/77 (55%), Gaps = 2/77 (2%)

Query: 156 RQGAVR-RRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHE 214
           R+GA R R++++ NGH F A    +  YC  C + IWG + +QGY+C  C  +VHKRCH 
Sbjct: 116 RRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWG-LARQGYRCINCKLLVHKRCHG 174

Query: 215 LIITKCAGLKKQETPDQ 231
           L+   C        P Q
Sbjct: 175 LVPLTCRKHMDSVMPSQ 191


>gi|75709228 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  374 bits (960), Expect = e-103
 Identities = 186/341 (54%), Positives = 242/341 (70%), Gaps = 8/341 (2%)

Query: 403 LGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILAL 462
           LGL +F+ I+V+G+GS+ KV+L  LK  D++YA+KV+KK+++  D+D+D   TEK +   
Sbjct: 64  LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123

Query: 463 ARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMF 522
           A  +P+L  L+ CFQT  RLF V+EYVNGGDLMF +QR RK  E  +RFYAAE+  AL F
Sbjct: 124 ASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNF 183

Query: 523 LHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQEL 582
           LH+ G+IYRDLKLDN+LLDA+GH KL D+GMCKEG+  G TT+TFCGTP+YIAPEIL+  
Sbjct: 184 LHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 243

Query: 583 EYGPSVDWWALGVLMYEMMAGQPPFE--ADN-----EDDLFESILHDDVLYPVWLSKEAV 635
           EYG SVDWWALGVLM+EMMAG+ PF+   DN     ED LF+ IL   +  P +LS +A 
Sbjct: 244 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303

Query: 636 SILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDV 695
            +LK F+ K+P +RLGC   Q G   IK H FF+ IDW LLE+K+  PPF+P+I     +
Sbjct: 304 HVLKGFLNKDPKERLGC-RPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGL 362

Query: 696 NNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLM 736
           +NFD  FT E   LT  DE  +K+I+Q EF+GF Y    L+
Sbjct: 363 DNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 403


>gi|75709226 protein kinase C, zeta isoform 2 [Homo sapiens]
          Length = 409

 Score =  374 bits (960), Expect = e-103
 Identities = 186/341 (54%), Positives = 242/341 (70%), Gaps = 8/341 (2%)

Query: 403 LGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILAL 462
           LGL +F+ I+V+G+GS+ KV+L  LK  D++YA+KV+KK+++  D+D+D   TEK +   
Sbjct: 64  LGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQ 123

Query: 463 ARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMF 522
           A  +P+L  L+ CFQT  RLF V+EYVNGGDLMF +QR RK  E  +RFYAAE+  AL F
Sbjct: 124 ASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNF 183

Query: 523 LHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQEL 582
           LH+ G+IYRDLKLDN+LLDA+GH KL D+GMCKEG+  G TT+TFCGTP+YIAPEIL+  
Sbjct: 184 LHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGE 243

Query: 583 EYGPSVDWWALGVLMYEMMAGQPPFE--ADN-----EDDLFESILHDDVLYPVWLSKEAV 635
           EYG SVDWWALGVLM+EMMAG+ PF+   DN     ED LF+ IL   +  P +LS +A 
Sbjct: 244 EYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKAS 303

Query: 636 SILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDV 695
            +LK F+ K+P +RLGC   Q G   IK H FF+ IDW LLE+K+  PPF+P+I     +
Sbjct: 304 HVLKGFLNKDPKERLGC-RPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGL 362

Query: 696 NNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSYFGEDLM 736
           +NFD  FT E   LT  DE  +K+I+Q EF+GF Y    L+
Sbjct: 363 DNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLL 403


>gi|5453974 protein kinase N2 [Homo sapiens]
          Length = 984

 Score =  351 bits (900), Expect = 2e-96
 Identities = 184/412 (44%), Positives = 259/412 (62%), Gaps = 13/412 (3%)

Query: 330 PQPASGSSPSEEDRSKSAPTSPC----DQEIKELENNIRKALSFDNRGEEHRAASSPDGQ 385
           P P   SS  E D S             + + +++N+    L       E++  +   G 
Sbjct: 576 PAPPRASSLGEIDESSELRVLDIPGQDSETVFDIQNDRNSILPKSQ--SEYKPDTPQSGL 633

Query: 386 LMSPGENGEVRQGQAK-RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVI 444
             S  +  E R+ Q + +  L +F    VLG+G FGKV+LAE K  +E++A+K LKK  I
Sbjct: 634 EYSGIQELEDRRSQQRFQFNLQDFRCCAVLGRGHFGKVLLAEYKNTNEMFAIKALKKGDI 693

Query: 445 LQDDDVDCTMTEKRILALAR--KHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSR 502
           +  D+VD  M EKRI       +HP+L  L+ CFQTK+ + FVMEY  GGDLM  I    
Sbjct: 694 VARDEVDSLMCEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD- 752

Query: 503 KFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGV 562
            F EPR+ FYAA V   L +LH+H ++YRDLKLDN+LLD EG  K+ADFG+CKEG+  G 
Sbjct: 753 VFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGD 812

Query: 563 TTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHD 622
            T+TFCGTP+++APE+L E  Y  +VDWW LGVL+YEM+ G+ PF  D+E+++F+SI++D
Sbjct: 813 RTSTFCGTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVND 872

Query: 623 DVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIK 682
           +V YP +LS EA+SI++  + +NP +RLG  AS+   + +K+HPFF+ IDW  L  KK+K
Sbjct: 873 EVRYPRFLSTEAISIMRRLLRRNPERRLG--ASEKDAEDVKKHPFFRLIDWSALMDKKVK 930

Query: 683 PPFKPRIKTKRDVNNFDQDFTREEPVLTLVDE-AIVKQINQEEFKGFSYFGE 733
           PPF P I+ + DV+NFD +FT E P+LT   E  I+ +  QE F+ F Y  +
Sbjct: 931 PPFIPTIRGREDVSNFDDEFTSEAPILTPPREPRILSEEEQEMFRDFDYIAD 982


>gi|4885549 AKT3 kinase isoform 1 [Homo sapiens]
          Length = 479

 Score =  333 bits (855), Expect = 3e-91
 Identities = 165/358 (46%), Positives = 236/358 (65%), Gaps = 4/358 (1%)

Query: 354 QEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENG-EVRQGQAKRLGLDEFNFIK 412
           +E +E    I+       R EE R   SP  Q+ + GE   +      KR  +++F+++K
Sbjct: 93  EEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLK 152

Query: 413 VLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQL 472
           +LGKG+FGKV+L   K   + YA+K+LKK+VI+  D+V  T+TE R+L   R HP+LT L
Sbjct: 153 LLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTSL 211

Query: 473 YCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRD 532
              FQTKDRL FVMEYVNGG+L F + R R F E R+RFY AE+ SAL +LH   ++YRD
Sbjct: 212 KYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRD 271

Query: 533 LKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWA 592
           LKL+N++LD +GH K+ DFG+CKEGI +  T  TFCGTP+Y+APE+L++ +YG +VDWW 
Sbjct: 272 LKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG 331

Query: 593 LGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGC 652
           LGV+MYEMM G+ PF   + + LFE IL +D+ +P  LS +A S+L   + K+P+KRLG 
Sbjct: 332 LGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLG- 390

Query: 653 VASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLT 710
               +    I +H FF  ++W  +  KK+ PPFKP++ ++ D   FD++FT +   +T
Sbjct: 391 -GGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITIT 447


>gi|32307163 AKT3 kinase isoform 2 [Homo sapiens]
          Length = 465

 Score =  333 bits (855), Expect = 3e-91
 Identities = 165/358 (46%), Positives = 236/358 (65%), Gaps = 4/358 (1%)

Query: 354 QEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENG-EVRQGQAKRLGLDEFNFIK 412
           +E +E    I+       R EE R   SP  Q+ + GE   +      KR  +++F+++K
Sbjct: 93  EEREEWTEAIQAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLK 152

Query: 413 VLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQL 472
           +LGKG+FGKV+L   K   + YA+K+LKK+VI+  D+V  T+TE R+L   R HP+LT L
Sbjct: 153 LLGKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTR-HPFLTSL 211

Query: 473 YCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRD 532
              FQTKDRL FVMEYVNGG+L F + R R F E R+RFY AE+ SAL +LH   ++YRD
Sbjct: 212 KYSFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRD 271

Query: 533 LKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWA 592
           LKL+N++LD +GH K+ DFG+CKEGI +  T  TFCGTP+Y+APE+L++ +YG +VDWW 
Sbjct: 272 LKLENLMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG 331

Query: 593 LGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGC 652
           LGV+MYEMM G+ PF   + + LFE IL +D+ +P  LS +A S+L   + K+P+KRLG 
Sbjct: 332 LGVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLG- 390

Query: 653 VASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLT 710
               +    I +H FF  ++W  +  KK+ PPFKP++ ++ D   FD++FT +   +T
Sbjct: 391 -GGPDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITIT 447


>gi|47132591 protein kinase N1 isoform 1 [Homo sapiens]
          Length = 948

 Score =  324 bits (830), Expect = 2e-88
 Identities = 165/377 (43%), Positives = 243/377 (64%), Gaps = 21/377 (5%)

Query: 336 SSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEV 395
           S  S +  S+  P+SP       L + I+++ + +   E      +P   L SP      
Sbjct: 565 SDSSPQKSSRDPPSSP-----SSLSSPIQESTAPELPSETQE---TPGPALCSPLRKSP- 615

Query: 396 RQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMT 455
                  L L++F F+ VLG+G FGKV+L+E +   E++A+K LKK  I+  D+V+  M 
Sbjct: 616 -------LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMC 668

Query: 456 EKRILALARK--HPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYA 513
           EKRILA      HP+L  L+ CFQT + + FVMEY  GGDLM  I  S  F EPR+ FY+
Sbjct: 669 EKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH-SDVFSEPRAIFYS 727

Query: 514 AEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDY 573
           A V   L FLH+H ++YRDLKLDN+LLD EG+ K+ADFG+CKEG+  G  T+TFCGTP++
Sbjct: 728 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 787

Query: 574 IAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKE 633
           +APE+L +  Y  +VDWW LGVL+YEM+ G+ PF  D+E+++F+SI++D+V YP +LS E
Sbjct: 788 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAE 847

Query: 634 AVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKR 693
           A+ I++  + +NP +RLG  +S+   + +K+ PFF+ + W  L  +++ PPF P +  + 
Sbjct: 848 AIGIMRRLLRRNPERRLG--SSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRT 905

Query: 694 DVNNFDQDFTREEPVLT 710
           DV+NFD++FT E P L+
Sbjct: 906 DVSNFDEEFTGEAPTLS 922



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 37/128 (28%), Positives = 61/128 (47%), Gaps = 16/128 (12%)

Query: 44  LNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQF- 102
           L +D++ +GQT+ K      AW   F  ++   R++ELAVF      + D    C ++F 
Sbjct: 401 LKLDNTVVGQTSWKP-CGPNAWDQSFTLELERARELELAVF------WRDQRGLCALKFL 453

Query: 103 --EELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAV 160
             E+ L N  RH E  +D+EP+G +   +       E       R+ R++    K+QG  
Sbjct: 454 KLEDFLDN-ERH-EVQLDMEPQGCLVAEVTFRNPVIE----RIPRLRRQKKIFSKQQGKA 507

Query: 161 RRRVHQVN 168
            +R  Q+N
Sbjct: 508 FQRARQMN 515


>gi|47132589 protein kinase N1 isoform 2 [Homo sapiens]
          Length = 942

 Score =  324 bits (830), Expect = 2e-88
 Identities = 165/377 (43%), Positives = 243/377 (64%), Gaps = 21/377 (5%)

Query: 336 SSPSEEDRSKSAPTSPCDQEIKELENNIRKALSFDNRGEEHRAASSPDGQLMSPGENGEV 395
           S  S +  S+  P+SP       L + I+++ + +   E      +P   L SP      
Sbjct: 559 SDSSPQKSSRDPPSSP-----SSLSSPIQESTAPELPSETQE---TPGPALCSPLRKSP- 609

Query: 396 RQGQAKRLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMT 455
                  L L++F F+ VLG+G FGKV+L+E +   E++A+K LKK  I+  D+V+  M 
Sbjct: 610 -------LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMC 662

Query: 456 EKRILALARK--HPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYA 513
           EKRILA      HP+L  L+ CFQT + + FVMEY  GGDLM  I  S  F EPR+ FY+
Sbjct: 663 EKRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIH-SDVFSEPRAIFYS 721

Query: 514 AEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDY 573
           A V   L FLH+H ++YRDLKLDN+LLD EG+ K+ADFG+CKEG+  G  T+TFCGTP++
Sbjct: 722 ACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEF 781

Query: 574 IAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKE 633
           +APE+L +  Y  +VDWW LGVL+YEM+ G+ PF  D+E+++F+SI++D+V YP +LS E
Sbjct: 782 LAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAE 841

Query: 634 AVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKR 693
           A+ I++  + +NP +RLG  +S+   + +K+ PFF+ + W  L  +++ PPF P +  + 
Sbjct: 842 AIGIMRRLLRRNPERRLG--SSERDAEDVKKQPFFRTLGWEALLARRLPPPFVPTLSGRT 899

Query: 694 DVNNFDQDFTREEPVLT 710
           DV+NFD++FT E P L+
Sbjct: 900 DVSNFDEEFTGEAPTLS 916



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 37/128 (28%), Positives = 61/128 (47%), Gaps = 16/128 (12%)

Query: 44  LNVDDSRIGQTATKQKTNSPAWHDEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQF- 102
           L +D++ +GQT+ K      AW   F  ++   R++ELAVF      + D    C ++F 
Sbjct: 395 LKLDNTVVGQTSWKP-CGPNAWDQSFTLELERARELELAVF------WRDQRGLCALKFL 447

Query: 103 --EELLQNGSRHFEDWIDLEPEGRVYVIIDLSGSSGEAPKDNEERVFRERMRPRKRQGAV 160
             E+ L N  RH E  +D+EP+G +   +       E       R+ R++    K+QG  
Sbjct: 448 KLEDFLDN-ERH-EVQLDMEPQGCLVAEVTFRNPVIE----RIPRLRRQKKIFSKQQGKA 501

Query: 161 RRRVHQVN 168
            +R  Q+N
Sbjct: 502 FQRARQMN 509


>gi|62241015 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  322 bits (825), Expect = 8e-88
 Identities = 170/364 (46%), Positives = 237/364 (65%), Gaps = 16/364 (4%)

Query: 375 EHRAASSPDGQLMSPGENGEVRQGQAK-RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEV 433
           + R+ S  D    S  E  EV   + K R+ ++EF ++K+LGKG+FGKV+L + K     
Sbjct: 119 DFRSGSPSDN---SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY 175

Query: 434 YAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGD 493
           YA+K+LKK+VI+  D+V  T+TE R+L  +R HP+LT L   FQT DRL FVMEY NGG+
Sbjct: 176 YAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYANGGE 234

Query: 494 LMFQIQRSRKFDEPRSRFYAAEVTSALMFLH-QHGVIYRDLKLDNILLDAEGHCKLADFG 552
           L F + R R F E R+RFY AE+ SAL +LH +  V+YRDLKL+N++LD +GH K+ DFG
Sbjct: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294

Query: 553 MCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNE 612
           +CKEGI +G T  TFCGTP+Y+APE+L++ +YG +VDWW LGV+MYEMM G+ PF   + 
Sbjct: 295 LCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354

Query: 613 DDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDA--IKQHPFFKE 670
           + LFE IL +++ +P  L  EA S+L   + K+P +RLG       EDA  I QH FF  
Sbjct: 355 EKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG----GGSEDAKEIMQHRFFAG 410

Query: 671 IDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDE----AIVKQINQEEFK 726
           I W  + +KK+ PPFKP++ ++ D   FD++FT +   +T  D+      V    +  F 
Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFP 470

Query: 727 GFSY 730
            FSY
Sbjct: 471 QFSY 474


>gi|62241013 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  322 bits (825), Expect = 8e-88
 Identities = 170/364 (46%), Positives = 237/364 (65%), Gaps = 16/364 (4%)

Query: 375 EHRAASSPDGQLMSPGENGEVRQGQAK-RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEV 433
           + R+ S  D    S  E  EV   + K R+ ++EF ++K+LGKG+FGKV+L + K     
Sbjct: 119 DFRSGSPSDN---SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY 175

Query: 434 YAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGD 493
           YA+K+LKK+VI+  D+V  T+TE R+L  +R HP+LT L   FQT DRL FVMEY NGG+
Sbjct: 176 YAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYANGGE 234

Query: 494 LMFQIQRSRKFDEPRSRFYAAEVTSALMFLH-QHGVIYRDLKLDNILLDAEGHCKLADFG 552
           L F + R R F E R+RFY AE+ SAL +LH +  V+YRDLKL+N++LD +GH K+ DFG
Sbjct: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294

Query: 553 MCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNE 612
           +CKEGI +G T  TFCGTP+Y+APE+L++ +YG +VDWW LGV+MYEMM G+ PF   + 
Sbjct: 295 LCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354

Query: 613 DDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDA--IKQHPFFKE 670
           + LFE IL +++ +P  L  EA S+L   + K+P +RLG       EDA  I QH FF  
Sbjct: 355 EKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG----GGSEDAKEIMQHRFFAG 410

Query: 671 IDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDE----AIVKQINQEEFK 726
           I W  + +KK+ PPFKP++ ++ D   FD++FT +   +T  D+      V    +  F 
Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFP 470

Query: 727 GFSY 730
            FSY
Sbjct: 471 QFSY 474


>gi|62241011 AKT1 kinase [Homo sapiens]
          Length = 480

 Score =  322 bits (825), Expect = 8e-88
 Identities = 170/364 (46%), Positives = 237/364 (65%), Gaps = 16/364 (4%)

Query: 375 EHRAASSPDGQLMSPGENGEVRQGQAK-RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEV 433
           + R+ S  D    S  E  EV   + K R+ ++EF ++K+LGKG+FGKV+L + K     
Sbjct: 119 DFRSGSPSDN---SGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRY 175

Query: 434 YAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGD 493
           YA+K+LKK+VI+  D+V  T+TE R+L  +R HP+LT L   FQT DRL FVMEY NGG+
Sbjct: 176 YAMKILKKEVIVAKDEVAHTLTENRVLQNSR-HPFLTALKYSFQTHDRLCFVMEYANGGE 234

Query: 494 LMFQIQRSRKFDEPRSRFYAAEVTSALMFLH-QHGVIYRDLKLDNILLDAEGHCKLADFG 552
           L F + R R F E R+RFY AE+ SAL +LH +  V+YRDLKL+N++LD +GH K+ DFG
Sbjct: 235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFG 294

Query: 553 MCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNE 612
           +CKEGI +G T  TFCGTP+Y+APE+L++ +YG +VDWW LGV+MYEMM G+ PF   + 
Sbjct: 295 LCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDH 354

Query: 613 DDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDA--IKQHPFFKE 670
           + LFE IL +++ +P  L  EA S+L   + K+P +RLG       EDA  I QH FF  
Sbjct: 355 EKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLG----GGSEDAKEIMQHRFFAG 410

Query: 671 IDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDE----AIVKQINQEEFK 726
           I W  + +KK+ PPFKP++ ++ D   FD++FT +   +T  D+      V    +  F 
Sbjct: 411 IVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFP 470

Query: 727 GFSY 730
            FSY
Sbjct: 471 QFSY 474


>gi|4502023 AKT2 kinase [Homo sapiens]
          Length = 481

 Score =  322 bits (824), Expect = 1e-87
 Identities = 161/348 (46%), Positives = 232/348 (66%), Gaps = 8/348 (2%)

Query: 388 SPGENGEVRQGQAK-RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQ 446
           S  E  EV   +A+ ++ +++F+++K+LGKG+FGKV+L   K     YA+K+L+K+VI+ 
Sbjct: 131 STTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIA 190

Query: 447 DDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDE 506
            D+V  T+TE R+L   R HP+LT L   FQT DRL FVMEY NGG+L F + R R F E
Sbjct: 191 KDEVAHTVTESRVLQNTR-HPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTE 249

Query: 507 PRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTT 566
            R+RFY AE+ SAL +LH   V+YRD+KL+N++LD +GH K+ DFG+CKEGI +G T  T
Sbjct: 250 ERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKT 309

Query: 567 FCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLY 626
           FCGTP+Y+APE+L++ +YG +VDWW LGV+MYEMM G+ PF   + + LFE IL +++ +
Sbjct: 310 FCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRF 369

Query: 627 PVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFK 686
           P  LS EA S+L   + K+P +RLG   S   E  + +H FF  I+W  + QKK+ PPFK
Sbjct: 370 PRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKE--VMEHRFFLSINWQDVVQKKLLPPFK 427

Query: 687 PRIKTKRDVNNFDQDFTREEPVLTLVDE----AIVKQINQEEFKGFSY 730
           P++ ++ D   FD +FT +   +T  D      +++   +  F  FSY
Sbjct: 428 PQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475


>gi|25168263 serum/glucocorticoid regulated kinase 1 isoform 1 [Homo
           sapiens]
          Length = 431

 Score =  296 bits (758), Expect = 5e-80
 Identities = 152/332 (45%), Positives = 219/332 (65%), Gaps = 13/332 (3%)

Query: 407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKH 466
           +F+F+KV+GKGSFGKV+LA  K ++  YAVKVL+K  IL+  +    M+E+ +L    KH
Sbjct: 97  DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 156

Query: 467 PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQH 526
           P+L  L+  FQT D+L+FV++Y+NGG+L + +QR R F EPR+RFYAAE+ SAL +LH  
Sbjct: 157 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 216

Query: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 586
            ++YRDLK +NILLD++GH  L DFG+CKE I +  TT+TFCGTP+Y+APE+L +  Y  
Sbjct: 217 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 276

Query: 587 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNP 646
           +VDWW LG ++YEM+ G PPF + N  +++++IL+  +     ++  A  +L+  + K+ 
Sbjct: 277 TVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDR 336

Query: 647 HKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREE 706
            KRLG   +++    IK H FF  I+W  L  KKI PPF P +    D+ +FD +FT EE
Sbjct: 337 TKRLG---AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFT-EE 392

Query: 707 PVLTLVDE--------AIVKQINQEEFKGFSY 730
           PV   + +        A VK+   E F GFSY
Sbjct: 393 PVPNSIGKSPDSVLVTASVKEA-AEAFLGFSY 423


>gi|219521880 serum/glucocorticoid regulated kinase 1 isoform 4
           [Homo sapiens]
          Length = 445

 Score =  296 bits (758), Expect = 5e-80
 Identities = 152/332 (45%), Positives = 219/332 (65%), Gaps = 13/332 (3%)

Query: 407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKH 466
           +F+F+KV+GKGSFGKV+LA  K ++  YAVKVL+K  IL+  +    M+E+ +L    KH
Sbjct: 111 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 170

Query: 467 PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQH 526
           P+L  L+  FQT D+L+FV++Y+NGG+L + +QR R F EPR+RFYAAE+ SAL +LH  
Sbjct: 171 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 230

Query: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 586
            ++YRDLK +NILLD++GH  L DFG+CKE I +  TT+TFCGTP+Y+APE+L +  Y  
Sbjct: 231 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 290

Query: 587 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNP 646
           +VDWW LG ++YEM+ G PPF + N  +++++IL+  +     ++  A  +L+  + K+ 
Sbjct: 291 TVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDR 350

Query: 647 HKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREE 706
            KRLG   +++    IK H FF  I+W  L  KKI PPF P +    D+ +FD +FT EE
Sbjct: 351 TKRLG---AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFT-EE 406

Query: 707 PVLTLVDE--------AIVKQINQEEFKGFSY 730
           PV   + +        A VK+   E F GFSY
Sbjct: 407 PVPNSIGKSPDSVLVTASVKEA-AEAFLGFSY 437


>gi|219521878 serum/glucocorticoid regulated kinase 1 isoform 3
           [Homo sapiens]
          Length = 459

 Score =  296 bits (758), Expect = 5e-80
 Identities = 152/332 (45%), Positives = 219/332 (65%), Gaps = 13/332 (3%)

Query: 407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKH 466
           +F+F+KV+GKGSFGKV+LA  K ++  YAVKVL+K  IL+  +    M+E+ +L    KH
Sbjct: 125 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 184

Query: 467 PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQH 526
           P+L  L+  FQT D+L+FV++Y+NGG+L + +QR R F EPR+RFYAAE+ SAL +LH  
Sbjct: 185 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 244

Query: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 586
            ++YRDLK +NILLD++GH  L DFG+CKE I +  TT+TFCGTP+Y+APE+L +  Y  
Sbjct: 245 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 304

Query: 587 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNP 646
           +VDWW LG ++YEM+ G PPF + N  +++++IL+  +     ++  A  +L+  + K+ 
Sbjct: 305 TVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDR 364

Query: 647 HKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREE 706
            KRLG   +++    IK H FF  I+W  L  KKI PPF P +    D+ +FD +FT EE
Sbjct: 365 TKRLG---AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFT-EE 420

Query: 707 PVLTLVDE--------AIVKQINQEEFKGFSY 730
           PV   + +        A VK+   E F GFSY
Sbjct: 421 PVPNSIGKSPDSVLVTASVKEA-AEAFLGFSY 451


>gi|219521876 serum/glucocorticoid regulated kinase 1 isoform 2
           [Homo sapiens]
          Length = 526

 Score =  296 bits (758), Expect = 5e-80
 Identities = 152/332 (45%), Positives = 219/332 (65%), Gaps = 13/332 (3%)

Query: 407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKH 466
           +F+F+KV+GKGSFGKV+LA  K ++  YAVKVL+K  IL+  +    M+E+ +L    KH
Sbjct: 192 DFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKH 251

Query: 467 PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQH 526
           P+L  L+  FQT D+L+FV++Y+NGG+L + +QR R F EPR+RFYAAE+ SAL +LH  
Sbjct: 252 PFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSL 311

Query: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 586
            ++YRDLK +NILLD++GH  L DFG+CKE I +  TT+TFCGTP+Y+APE+L +  Y  
Sbjct: 312 NIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDR 371

Query: 587 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNP 646
           +VDWW LG ++YEM+ G PPF + N  +++++IL+  +     ++  A  +L+  + K+ 
Sbjct: 372 TVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDR 431

Query: 647 HKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREE 706
            KRLG   +++    IK H FF  I+W  L  KKI PPF P +    D+ +FD +FT EE
Sbjct: 432 TKRLG---AKDDFMEIKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFT-EE 487

Query: 707 PVLTLVDE--------AIVKQINQEEFKGFSY 730
           PV   + +        A VK+   E F GFSY
Sbjct: 488 PVPNSIGKSPDSVLVTASVKEA-AEAFLGFSY 518


>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  295 bits (755), Expect = 1e-79
 Identities = 148/330 (44%), Positives = 212/330 (64%), Gaps = 9/330 (2%)

Query: 407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKH 466
           +F+F+KV+GKGSFGKV+LA+ K   + YAVKVL+K ++L   +    M E+ +L    KH
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220

Query: 467 PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQH 526
           P+L  L+  FQT ++L+FV+++VNGG+L F +QR R F E R+RFYAAE+ SAL +LH  
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280

Query: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 586
            ++YRDLK +NILLD+ GH  L DFG+CKEGI    TTTTFCGTP+Y+APE++++  Y  
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340

Query: 587 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNP 646
           +VDWW LG ++YEM+ G PPF   +  +++++ILH  +     +S  A SIL+  + K+ 
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400

Query: 647 HKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREE 706
             RLG   ++     I+ HPFF+ + W  L QKKI PPF P +    D+ NFD  FT E 
Sbjct: 401 QNRLG---AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEET 457

Query: 707 PVLTLVDEAIVKQIN------QEEFKGFSY 730
              ++   +    +N       + F GFSY
Sbjct: 458 VPYSVCVSSDYSIVNASVLEADDAFVGFSY 487


>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
           sapiens]
          Length = 496

 Score =  295 bits (755), Expect = 1e-79
 Identities = 148/330 (44%), Positives = 212/330 (64%), Gaps = 9/330 (2%)

Query: 407 EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKH 466
           +F+F+KV+GKGSFGKV+LA+ K   + YAVKVL+K ++L   +    M E+ +L    KH
Sbjct: 161 DFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKH 220

Query: 467 PYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQH 526
           P+L  L+  FQT ++L+FV+++VNGG+L F +QR R F E R+RFYAAE+ SAL +LH  
Sbjct: 221 PFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSI 280

Query: 527 GVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGP 586
            ++YRDLK +NILLD+ GH  L DFG+CKEGI    TTTTFCGTP+Y+APE++++  Y  
Sbjct: 281 KIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDN 340

Query: 587 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNP 646
           +VDWW LG ++YEM+ G PPF   +  +++++ILH  +     +S  A SIL+  + K+ 
Sbjct: 341 TVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDR 400

Query: 647 HKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREE 706
             RLG   ++     I+ HPFF+ + W  L QKKI PPF P +    D+ NFD  FT E 
Sbjct: 401 QNRLG---AKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEET 457

Query: 707 PVLTLVDEAIVKQIN------QEEFKGFSY 730
              ++   +    +N       + F GFSY
Sbjct: 458 VPYSVCVSSDYSIVNASVLEADDAFVGFSY 487


>gi|20127541 serum/glucocorticoid regulated kinase 2 isoform beta
           [Homo sapiens]
          Length = 427

 Score =  293 bits (750), Expect = 4e-79
 Identities = 157/367 (42%), Positives = 225/367 (61%), Gaps = 12/367 (3%)

Query: 376 HRAASSPDGQLMSPGE---NGEVRQGQAKRLGLD--EFNFIKVLGKGSFGKVMLAELKGK 430
           +R  SSP G   SP     NG +  G +        +F+F+KV+GKG++GKV+LA+ K  
Sbjct: 59  YRMNSSPAGT-PSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSD 117

Query: 431 DEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVN 490
              YAVKVL+K  IL+  +    M E+ +L    +HP+L  L   FQT ++L+FV++YVN
Sbjct: 118 GAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVN 177

Query: 491 GGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLAD 550
           GG+L F +QR R+F EPR+RFYAAEV SA+ +LH   +IYRDLK +NILLD +GH  L D
Sbjct: 178 GGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTD 237

Query: 551 FGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEAD 610
           FG+CKEG+    TT+TFCGTP+Y+APE+L++  Y  +VDWW LG ++YEM+ G PPF + 
Sbjct: 238 FGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQ 297

Query: 611 NEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKE 670
           +   ++E+ILH  +  P   +  A  +L++ + K+  +RLG   S+     IK H FF  
Sbjct: 298 DVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLG---SKADFLEIKNHVFFSP 354

Query: 671 IDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTRE---EPVLTLVDEAIVKQINQEEFKG 727
           I+W  L  K++ PPF P +    D+ +FD +FT+E   + +    D           F G
Sbjct: 355 INWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLG 414

Query: 728 FSYFGED 734
           FSY  ED
Sbjct: 415 FSYAPED 421


>gi|25168261 serum/glucocorticoid regulated kinase 2 isoform alpha
           [Homo sapiens]
          Length = 367

 Score =  292 bits (748), Expect = 7e-79
 Identities = 150/348 (43%), Positives = 217/348 (62%), Gaps = 8/348 (2%)

Query: 392 NGEVRQGQAKRLGLD--EFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDD 449
           NG +  G +        +F+F+KV+GKG++GKV+LA+ K     YAVKVL+K  IL+  +
Sbjct: 17  NGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKE 76

Query: 450 VDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRS 509
               M E+ +L    +HP+L  L   FQT ++L+FV++YVNGG+L F +QR R+F EPR+
Sbjct: 77  QSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRA 136

Query: 510 RFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCG 569
           RFYAAEV SA+ +LH   +IYRDLK +NILLD +GH  L DFG+CKEG+    TT+TFCG
Sbjct: 137 RFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCG 196

Query: 570 TPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVW 629
           TP+Y+APE+L++  Y  +VDWW LG ++YEM+ G PPF + +   ++E+ILH  +  P  
Sbjct: 197 TPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGG 256

Query: 630 LSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPFKPRI 689
            +  A  +L++ + K+  +RLG   S+     IK H FF  I+W  L  K++ PPF P +
Sbjct: 257 RTVAACDLLQSLLHKDQRQRLG---SKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNV 313

Query: 690 KTKRDVNNFDQDFTRE---EPVLTLVDEAIVKQINQEEFKGFSYFGED 734
               D+ +FD +FT+E   + +    D           F GFSY  ED
Sbjct: 314 TGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPED 361


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,233,905
Number of Sequences: 37866
Number of extensions: 1459836
Number of successful extensions: 7163
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 745
Number of HSP's successfully gapped in prelim test: 140
Number of HSP's that attempted gapping in prelim test: 4459
Number of HSP's gapped (non-prelim): 1234
length of query: 737
length of database: 18,247,518
effective HSP length: 110
effective length of query: 627
effective length of database: 14,082,258
effective search space: 8829575766
effective search space used: 8829575766
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.