Guide to the Human Genome
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Search of human proteins with 4885369

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4885369 granzyme M precursor [Homo sapiens]
         (257 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4885369 granzyme M precursor [Homo sapiens]                        519   e-148
gi|42544239 complement factor D preproprotein [Homo sapiens]          185   3e-47
gi|47551347 protease, serine-like 1 [Homo sapiens]                    171   6e-43
gi|4504235 granzyme K precursor [Homo sapiens]                        156   1e-38
gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo s...   150   1e-36
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   148   5e-36
gi|221625528 granzyme B precursor [Homo sapiens]                      144   1e-34
gi|5453676 granzyme A precursor [Homo sapiens]                        144   1e-34
gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens]     139   2e-33
gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens]          139   2e-33
gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens]       139   2e-33
gi|15529990 granzyme H [Homo sapiens]                                 139   2e-33
gi|4503149 cathepsin G preproprotein [Homo sapiens]                   139   3e-33
gi|15559207 elastase 2A preproprotein [Homo sapiens]                  138   5e-33
gi|4503549 neutrophil elastase preproprotein [Homo sapiens]           137   7e-33
gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprot...   136   2e-32
gi|71361688 myeloblastin [Homo sapiens]                               136   2e-32
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          136   2e-32
gi|11496281 kallikrein 13 precursor [Homo sapiens]                    134   6e-32
gi|29244926 corin [Homo sapiens]                                      134   8e-32
gi|33695155 hepsin [Homo sapiens]                                     134   1e-31
gi|4504481 hepsin [Homo sapiens]                                      134   1e-31
gi|4505881 plasminogen [Homo sapiens]                                 132   3e-31
gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens]        130   9e-31
gi|58331209 chymotrypsin-like elastase family, member 1 [Homo sa...   130   1e-30
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   129   2e-30
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   129   2e-30
gi|11342670 azurocidin 1 preproprotein [Homo sapiens]                 129   3e-30
gi|21464127 kallikrein 8 isoform 2 [Homo sapiens]                     129   3e-30
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           129   3e-30

>gi|4885369 granzyme M precursor [Homo sapiens]
          Length = 257

 Score =  519 bits (1337), Expect = e-148
 Identities = 257/257 (100%), Positives = 257/257 (100%)

Query: 1   MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKW 60
           MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKW
Sbjct: 1   MEACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKW 60

Query: 61  VLTAAHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGK 120
           VLTAAHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGK
Sbjct: 61  VLTAAHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGK 120

Query: 121 VKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSR 180
           VKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSR
Sbjct: 121 VKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSR 180

Query: 181 FWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVAT 240
           FWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVAT
Sbjct: 181 FWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVAT 240

Query: 241 AVAPYVSWIRKVTGRSA 257
           AVAPYVSWIRKVTGRSA
Sbjct: 241 AVAPYVSWIRKVTGRSA 257


>gi|42544239 complement factor D preproprotein [Homo sapiens]
          Length = 253

 Score =  185 bits (470), Expect = 3e-47
 Identities = 103/248 (41%), Positives = 150/248 (60%), Gaps = 9/248 (3%)

Query: 9   LVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCL 68
           +++ LGA +  +    +I+GGRE   H+RPYMAS+Q NG+HLCGGVLV  +WVL+AAHCL
Sbjct: 9   VLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCL 68

Query: 69  AQRM-AQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLALLQLDGKVKPS 124
                 +++++LG H+L  P  +   + +  A+ HP  +P   +++DL LLQL  K    
Sbjct: 69  EDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQP-DTIDHDLLLLQLSEKATLG 127

Query: 125 RTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNG 184
             +RPL      + VA GT C +AGWG+ +  GR    L+ + L VLD   CN     +G
Sbjct: 128 PAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDG 187

Query: 185 SLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVAP 244
           +++  ++C  ++ +D   CKGDSGGPLVC  G VL GV++  SRVC +  KP + T VA 
Sbjct: 188 AITERLMCAESNRRDS--CKGDSGGPLVC--GGVLEGVVTSGSRVCGNRKKPGIYTRVAS 243

Query: 245 YVSWIRKV 252
           Y +WI  V
Sbjct: 244 YAAWIDSV 251


>gi|47551347 protease, serine-like 1 [Homo sapiens]
          Length = 283

 Score =  171 bits (433), Expect = 6e-43
 Identities = 106/243 (43%), Positives = 140/243 (57%), Gaps = 11/243 (4%)

Query: 21  SFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQRMAQLRL-VL 79
           S+G QIIGG EV PHSRPYMAS++  G H CGG L+  +WV++AAHC + R  +  L VL
Sbjct: 29  SWGAQIIGGHEVTPHSRPYMASVRFGGQHHCGGFLLRARWVVSAAHCFSHRDLRTGLVVL 88

Query: 80  GLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKR 136
           G H L +   T   F I A   HP Y P+    ND+ LL+L+G       +  L LP +R
Sbjct: 89  GAHVLSTAEPTQQVFGIDALTTHPDYHPM-THANDICLLRLNGSAVLGPAVGLLRLPGRR 147

Query: 137 -QVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCL-A 194
            +   AGTRC +AGWG       L   L E  ++VLD  +CN+S  W G L+ +M+C  +
Sbjct: 148 ARPPTAGTRCRVAGWGFVSDFEELPPGLMEAKVRVLDPDVCNSS--WKGHLTLTMLCTRS 205

Query: 195 ADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVAPYVSWIRKVTG 254
            DS  +  C  DSGGPLVC + R   G++SFS   C D   P V T V+ +V+WI  V  
Sbjct: 206 GDSHRRGFCSADSGGPLVC-RNRA-HGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVR 263

Query: 255 RSA 257
           RS+
Sbjct: 264 RSS 266


>gi|4504235 granzyme K precursor [Homo sapiens]
          Length = 264

 Score =  156 bits (395), Expect = 1e-38
 Identities = 102/254 (40%), Positives = 145/254 (57%), Gaps = 16/254 (6%)

Query: 7   SLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAH 66
           SL  L +GA      F  +IIGG+EV PHSRP+MAS+Q  G H+CGGVL+ P+WVLTAAH
Sbjct: 8   SLFFLIVGAYMTHVCFNMEIIGGKEVSPHSRPFMASIQYGGHHVCGGVLIDPQWVLTAAH 67

Query: 67  CLAQ--RMAQLRLVLGLHTL---DSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGKV 121
           C  +  +     +VLG H+L   ++   T  IK  I   R    P   ND+ L++L    
Sbjct: 68  CQYRFTKGQSPTVVLGAHSLSKNEASKQTLEIKKFIPFSRVTSDPQ-SNDIMLVKLQTAA 126

Query: 122 KPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGG-RLSRVLRELDLQVLDTRMCNNSR 180
           K ++ ++ L + SK   + +GT+C + GWG T     R S  LRE+ + VL  ++CN+  
Sbjct: 127 KLNKHVKMLHIRSKTS-LRSGTKCKVTGWGATDPDSLRPSDTLREVTVTVLSRKLCNSQS 185

Query: 181 FWNGS--LSPSMVCLAADSKDQA-PCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPP 237
           ++NG   ++  MVC A D+K Q   CKGDSGGPL+C KG V   ++S     C    KP 
Sbjct: 186 YYNGDPFITKDMVC-AGDAKGQKDSCKGDSGGPLIC-KG-VFHAIVS-GGHECGVATKPG 241

Query: 238 VATAVA-PYVSWIR 250
           + T +   Y +WI+
Sbjct: 242 IYTLLTKKYQTWIK 255


>gi|89142741 kallikrein-related peptidase 4 preproprotein [Homo
           sapiens]
          Length = 254

 Score =  150 bits (378), Expect = 1e-36
 Identities = 93/253 (36%), Positives = 134/253 (52%), Gaps = 17/253 (6%)

Query: 8   LLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHC 67
           L++   G+L  GS   +QII G +  PHS+P+ A+L       C GVLVHP+WVL+AAHC
Sbjct: 15  LILGVAGSLVSGSC--SQIINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAHC 72

Query: 68  LAQRMAQLRLVLGLHTLDS---PGLTF-HIKAAIQHPRYKPVPALENDLALLQLDGKVKP 123
                    + LGLH+L++   PG        +++HP Y   P L NDL L++LD  V  
Sbjct: 73  FQN---SYTIGLGLHSLEADQEPGSQMVEASLSVRHPEYNR-PLLANDLMLIKLDESVSE 128

Query: 124 SRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWN 183
           S TIR +++ S  Q   AG  C ++GWGL    GR+  VL+ +++ V+   +C  S+ ++
Sbjct: 129 SDTIRSISIAS--QCPTAGNSCLVSGWGLL-ANGRMPTVLQCVNVSVVSEEVC--SKLYD 183

Query: 184 GSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVA 243
               PSM C       +  C GDSGGPL+C     L G++SF    C  +  P V T + 
Sbjct: 184 PLYHPSMFCAGGGHDQKDSCNGDSGGPLIC--NGYLQGLVSFGKAPCGQVGVPGVYTNLC 241

Query: 244 PYVSWIRKVTGRS 256
            +  WI K    S
Sbjct: 242 KFTEWIEKTVQAS 254


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  148 bits (373), Expect = 5e-36
 Identities = 89/257 (34%), Positives = 137/257 (53%), Gaps = 9/257 (3%)

Query: 2   EACVSSLLV-LALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKW 60
           E C S  +V L   A      + ++I+GG   +    P+ ASLQ  G HLCGG ++ P W
Sbjct: 192 EGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLW 251

Query: 61  VLTAAHCLAQRM--AQLRLVLGL-HTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQL 117
           ++TAAHC+          + +GL   LD+P  +  ++  + H +YKP   L ND+AL++L
Sbjct: 252 IITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKP-KRLGNDIALMKL 310

Query: 118 DGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQG-GRLSRVLRELDLQVLDTRMC 176
            G +  +  I+P+ LP+  +    G  C  +GWG T  G G  S VL    + ++  ++C
Sbjct: 311 AGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKIC 370

Query: 177 NNSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRV--LAGVLSFSSRVCTDIF 234
           N+   + G +SPSM+C    +     C+GDSGGPLVC + R+  L G  SF    C ++ 
Sbjct: 371 NHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIG-CAEVN 429

Query: 235 KPPVATAVAPYVSWIRK 251
           KP V T V  ++ WI +
Sbjct: 430 KPGVYTRVTSFLDWIHE 446


>gi|221625528 granzyme B precursor [Homo sapiens]
          Length = 247

 Score =  144 bits (362), Expect = 1e-34
 Identities = 91/255 (35%), Positives = 132/255 (51%), Gaps = 20/255 (7%)

Query: 9   LVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQ---RNGSHLCGGVLVHPKWVLTAA 65
           ++L L  L +  +   +IIGG E  PHSRPYMA L    +     CGG L+   +VLTAA
Sbjct: 4   ILLLLAFLLLPRADAGEIIGGHEAKPHSRPYMAYLMIWDQKSLKRCGGFLIRDDFVLTAA 63

Query: 66  HCLAQRMAQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLALLQLDGKVK 122
           HC     + + + LG H +     T     +K  I HP Y P     ND+ LLQL+ K K
Sbjct: 64  HCWG---SSINVTLGAHNIKEQEPTQQFIPVKRPIPHPAYNP-KNFSNDIMLLQLERKAK 119

Query: 123 PSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNS--R 180
            +R ++PL LPS +  V  G  CS+AGWG T   G+ S  L+E+ + V + R C +    
Sbjct: 120 RTRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRH 179

Query: 181 FWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVAT 240
           +++ ++    +C+      +   KGDSGGPLVC K  V  G++S+      +   P   T
Sbjct: 180 YYDSTIE---LCVGDPEIKKTSFKGDSGGPLVCNK--VAQGIVSYGR---NNGMPPRACT 231

Query: 241 AVAPYVSWIRKVTGR 255
            V+ +V WI+K   R
Sbjct: 232 KVSSFVHWIKKTMKR 246


>gi|5453676 granzyme A precursor [Homo sapiens]
          Length = 262

 Score =  144 bits (362), Expect = 1e-34
 Identities = 91/252 (36%), Positives = 131/252 (51%), Gaps = 12/252 (4%)

Query: 5   VSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTA 64
           ++S L + +  L +      +IIGG EV PHSRPYM  L  +   +C G L+   WVLTA
Sbjct: 8   LASSLSVVVSLLLIPEDVCEKIIGGNEVTPHSRPYMVLLSLDRKTICAGALIAKDWVLTA 67

Query: 65  AHCLAQRMAQLRLVLGLHTLDSPGLTFHI---KAAIQHPRYKPVPALENDLALLQLDGKV 121
           AHC   + +Q+  +LG H++     T  I   K    +P Y P    E DL LLQL  K 
Sbjct: 68  AHCNLNKRSQV--ILGAHSITREEPTKQIMLVKKEFPYPCYDPATR-EGDLKLLQLTEKA 124

Query: 122 KPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRF 181
           K ++ +  L LP K   V  GT C +AGWG TH     S  LRE+++ ++D ++CN+   
Sbjct: 125 KINKYVTILHLPKKGDDVKPGTMCQVAGWGRTHNSASWSDTLREVNITIIDRKVCNDRNH 184

Query: 182 WNGS--LSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFS-SRVCTDIFKPPV 238
           +N +  +  +MVC  +    +  C GDSG PL+C    V  GV SF     C D   P V
Sbjct: 185 YNFNPVIGMNMVCAGSLRGGRDSCNGDSGSPLLC--EGVFRGVTSFGLENKCGDPRGPGV 242

Query: 239 ATAVA-PYVSWI 249
              ++  +++WI
Sbjct: 243 YILLSKKHLNWI 254


>gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
          Length = 250

 Score =  139 bits (351), Expect = 2e-33
 Identities = 90/254 (35%), Positives = 134/254 (52%), Gaps = 18/254 (7%)

Query: 5   VSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTA 64
           +  L++LAL    VG    T+II G E  PHS+P+ A+L      LCG  L+ P+W+LTA
Sbjct: 3   ILQLILLALATGLVGGE--TRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTA 60

Query: 65  AHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQ---HPRYK---PVPALENDLALLQLD 118
           AHCL  R     + LG H L         + A +   HP +    P     ND+ L+++ 
Sbjct: 61  AHCLKPRYI---VHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMA 117

Query: 119 GKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGG-RLSRVLRELDLQVLDTRMCN 177
             V  +  +RPL L S+   V AGT C ++GWG T     RL   LR  ++ +++ + C 
Sbjct: 118 SPVSITWAVRPLTLSSR--CVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCE 175

Query: 178 NSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPP 237
           N+  + G+++ +MVC +     +  C+GDSGGPLVC +   L G++S+    C    KP 
Sbjct: 176 NA--YPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQS--LQGIISWGQDPCAITRKPG 231

Query: 238 VATAVAPYVSWIRK 251
           V T V  YV WI++
Sbjct: 232 VYTKVCKYVDWIQE 245


>gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens]
          Length = 282

 Score =  139 bits (351), Expect = 2e-33
 Identities = 90/254 (35%), Positives = 134/254 (52%), Gaps = 18/254 (7%)

Query: 5   VSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTA 64
           +  L++LAL    VG    T+II G E  PHS+P+ A+L      LCG  L+ P+W+LTA
Sbjct: 35  ILQLILLALATGLVGGE--TRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTA 92

Query: 65  AHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQ---HPRYK---PVPALENDLALLQLD 118
           AHCL  R     + LG H L         + A +   HP +    P     ND+ L+++ 
Sbjct: 93  AHCLKPRYI---VHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMA 149

Query: 119 GKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGG-RLSRVLRELDLQVLDTRMCN 177
             V  +  +RPL L S+   V AGT C ++GWG T     RL   LR  ++ +++ + C 
Sbjct: 150 SPVSITWAVRPLTLSSR--CVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCE 207

Query: 178 NSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPP 237
           N+  + G+++ +MVC +     +  C+GDSGGPLVC +   L G++S+    C    KP 
Sbjct: 208 NA--YPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQS--LQGIISWGQDPCAITRKPG 263

Query: 238 VATAVAPYVSWIRK 251
           V T V  YV WI++
Sbjct: 264 VYTKVCKYVDWIQE 277


>gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
          Length = 250

 Score =  139 bits (351), Expect = 2e-33
 Identities = 90/254 (35%), Positives = 134/254 (52%), Gaps = 18/254 (7%)

Query: 5   VSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTA 64
           +  L++LAL    VG    T+II G E  PHS+P+ A+L      LCG  L+ P+W+LTA
Sbjct: 3   ILQLILLALATGLVGGE--TRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTA 60

Query: 65  AHCLAQRMAQLRLVLGLHTLDSPGLTFHIKAAIQ---HPRYK---PVPALENDLALLQLD 118
           AHCL  R     + LG H L         + A +   HP +    P     ND+ L+++ 
Sbjct: 61  AHCLKPRYI---VHLGQHNLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMA 117

Query: 119 GKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGG-RLSRVLRELDLQVLDTRMCN 177
             V  +  +RPL L S+   V AGT C ++GWG T     RL   LR  ++ +++ + C 
Sbjct: 118 SPVSITWAVRPLTLSSR--CVTAGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCE 175

Query: 178 NSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPP 237
           N+  + G+++ +MVC +     +  C+GDSGGPLVC +   L G++S+    C    KP 
Sbjct: 176 NA--YPGNITDTMVCASVQEGGKDSCQGDSGGPLVCNQS--LQGIISWGQDPCAITRKPG 231

Query: 238 VATAVAPYVSWIRK 251
           V T V  YV WI++
Sbjct: 232 VYTKVCKYVDWIQE 245


>gi|15529990 granzyme H [Homo sapiens]
          Length = 246

 Score =  139 bits (351), Expect = 2e-33
 Identities = 95/253 (37%), Positives = 130/253 (51%), Gaps = 19/253 (7%)

Query: 10  VLALGALSVGSSFGTQIIGGREVIPHSRPYMAS---LQRNGSHLCGGVLVHPKWVLTAAH 66
           +L L  L    +   +IIGG E  PHSRPYMA    LQ      CGG+LV   +VLTAAH
Sbjct: 5   LLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVLTAAH 64

Query: 67  CLAQRMAQLRLVLGLHTLDSPGLT---FHIKAAIQHPRYKPVPALENDLALLQLDGKVKP 123
           C     + + + LG H +     T     +K  I HP Y P     ND+ LLQL+ K K 
Sbjct: 65  CQG---SSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNP-KNFSNDIMLLQLERKAKW 120

Query: 124 SRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWN 183
           +  +RPL LPS +  V  G  CS+AGWG       L+  L+E+ L V   + C   R ++
Sbjct: 121 TTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSM-STLATTLQEVLLTV--QKDCQCERLFH 177

Query: 184 GSLS-PSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAV 242
           G+ S  + +C+    K Q   KGDSGGPLVC    V  G+LS+ ++  T    P V   V
Sbjct: 178 GNYSRATEICVGDPKKTQTGFKGDSGGPLVCKD--VAQGILSYGNKKGT---PPGVYIKV 232

Query: 243 APYVSWIRKVTGR 255
           + ++ WI++   R
Sbjct: 233 SHFLPWIKRTMKR 245


>gi|4503149 cathepsin G preproprotein [Homo sapiens]
          Length = 255

 Score =  139 bits (349), Expect = 3e-33
 Identities = 99/250 (39%), Positives = 138/250 (55%), Gaps = 21/250 (8%)

Query: 8   LLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRN---GSHLCGGVLVHPKWVLTA 64
           LL+L    L  G+  G +IIGGRE  PHSRPYMA LQ     G   CGG LV   +VLTA
Sbjct: 4   LLLLLAFLLPTGAEAG-EIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVLTA 62

Query: 65  AHCLAQRMAQLRLVLGLHTLDSPGLTF-HIKA--AIQHPRYKPVPALENDLALLQLDGKV 121
           AHC     + + + LG H +     T  HI A  AI+HP+Y     ++ND+ LLQL  +V
Sbjct: 63  AHCWG---SNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQ-RTIQNDIMLLQLSRRV 118

Query: 122 KPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRF 181
           + +R + P+ALP  ++ +  GT C++AGWG      R +  LRE+ L+V   R C   R 
Sbjct: 119 RRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSM-RRGTDTLREVQLRVQRDRQC--LRI 175

Query: 182 WNGSLSP-SMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVAT 240
           + GS  P   +C+    + +A  KGDSGGPL+C    V  G++S+     +    P V T
Sbjct: 176 F-GSYDPRRQICVGDRRERKAAFKGDSGGPLLC--NNVAHGIVSYGK---SSGVPPEVFT 229

Query: 241 AVAPYVSWIR 250
            V+ ++ WIR
Sbjct: 230 RVSSFLPWIR 239


>gi|15559207 elastase 2A preproprotein [Homo sapiens]
          Length = 269

 Score =  138 bits (347), Expect = 5e-33
 Identities = 92/261 (35%), Positives = 132/261 (50%), Gaps = 18/261 (6%)

Query: 8   LLVLALGALSVGSS----FGTQIIGGREVIPHSRPYMASLQRNGS----HLCGGVLVHPK 59
           L  L  GALS G      + T+++GG E  P+S P+  SLQ + +    H CGG L+   
Sbjct: 7   LSTLVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANS 66

Query: 60  WVLTAAHCLAQRMAQLRLVLGLHTL---DSPGLTFHIKAAIQHPRYKPVPALE-NDLALL 115
           WVLTAAHC++      R+ LG H L   +S  L   +   + H  +      + ND+ALL
Sbjct: 67  WVLTAAHCISSSRTY-RVGLGRHNLYVAESGSLAVSVSKIVVHKDWNSNQISKGNDIALL 125

Query: 116 QLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRM 175
           +L   V  +  I+   LP    ++     C + GWG     G +  VL++  L V+D   
Sbjct: 126 KLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRLLVVDYAT 185

Query: 176 CNNSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVC--GKGR-VLAGVLSFSSRV-CT 231
           C++S +W  S+  SM+C   D    + C GDSGGPL C    GR  + G++SF SR+ C 
Sbjct: 186 CSSSAWWGSSVKTSMICAGGDGVISS-CNGDSGGPLNCQASDGRWQVHGIVSFGSRLGCN 244

Query: 232 DIFKPPVATAVAPYVSWIRKV 252
              KP V T V+ Y+ WI  V
Sbjct: 245 YYHKPSVFTRVSNYIDWINSV 265


>gi|4503549 neutrophil elastase preproprotein [Homo sapiens]
          Length = 267

 Score =  137 bits (346), Expect = 7e-33
 Identities = 87/257 (33%), Positives = 130/257 (50%), Gaps = 23/257 (8%)

Query: 3   ACVSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVL 62
           ACV   L+L       G++  ++I+GGR   PH+ P+M SLQ  G H CG  L+ P +V+
Sbjct: 13  ACVLPALLLG------GTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVM 66

Query: 63  TAAHCLAQ-RMAQLRLVLGLHTLDSPGLTFHIKAA--IQHPRYKPVPALENDLALLQLDG 119
           +AAHC+A   +  +R+VLG H L     T  + A   I    Y PV  L ND+ +LQL+G
Sbjct: 67  SAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLL-NDIVILQLNG 125

Query: 120 KVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNS 179
               +  ++   LP++ + +  G +C   GWGL  +   ++ VL+EL++ V+ T +C  S
Sbjct: 126 SATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVV-TSLCRRS 184

Query: 180 RFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVA 239
                      VC     +    C GDSG PLVC    ++ G+ SF    C     P   
Sbjct: 185 N----------VCTLVRGRQAGVCFGDSGSPLVC--NGLIHGIASFVRGGCASGLYPDAF 232

Query: 240 TAVAPYVSWIRKVTGRS 256
             VA +V+WI  +  RS
Sbjct: 233 APVAQFVNWIDSIIQRS 249


>gi|20302143 kallikrein-related peptidase 15 isoform 4 preproprotein
           [Homo sapiens]
          Length = 256

 Score =  136 bits (343), Expect = 2e-32
 Identities = 89/263 (33%), Positives = 133/263 (50%), Gaps = 24/263 (9%)

Query: 8   LLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHC 67
           LL L+    S  +  G +++ G E  PHS+P+  +L   G   CG  L+ P WVL+AAHC
Sbjct: 4   LLTLSFLLASTAAQDGDKLLEGDECAPHSQPWQVALYERGRFNCGASLISPHWVLSAAHC 63

Query: 68  LAQRMAQLRLVLGLHTL---DSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPS 124
            ++ M   R+ LG H L   D P         I HPRY+   +  ND+ LL+L    + +
Sbjct: 64  QSRFM---RVRLGEHNLRKRDGPEQLRTTSRVIPHPRYE-ARSHRNDIMLLRLVQPARLN 119

Query: 125 RTIRPLALPSKRQVVAAGTRCSMAGWGLTHQ------GGRLSRV-----LRELDLQVLDT 173
             +RP  LP++      G  C ++GWGL         G   S+V     L   ++ ++  
Sbjct: 120 PQVRPAVLPTR--CPHPGEACVVSGWGLVSHNEPGTAGSPRSQVSLPDTLHCANISIISD 177

Query: 174 RMCNNSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDI 233
             C+ S  + G L+ +MVC  A+ +    C+GDSGGPLVC  G +L G++S+    C + 
Sbjct: 178 TSCDKS--YPGRLTNTMVCAGAEGRGAESCEGDSGGPLVC--GGILQGIVSWGDVPCDNT 233

Query: 234 FKPPVATAVAPYVSWIRKVTGRS 256
            KP V T V  Y+ WIR+   R+
Sbjct: 234 TKPGVYTKVCHYLEWIRETMKRN 256


>gi|71361688 myeloblastin [Homo sapiens]
          Length = 256

 Score =  136 bits (342), Expect = 2e-32
 Identities = 92/254 (36%), Positives = 123/254 (48%), Gaps = 18/254 (7%)

Query: 7   SLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNG---SHLCGGVLVHPKWVLT 63
           +L  + L  L  G++   +I+GG E  PHSRPYMASLQ  G   SH CGG L+HP +VLT
Sbjct: 9   ALASVLLALLLSGAARAAEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLT 68

Query: 64  AAHCLAQRMAQL-RLVLGLHTLDSPGLT-FHIKAAIQHPRYKPVPALENDLALLQLDGKV 121
           AAHCL     +L  +VLG H + +   T  H   A             ND+ L+QL    
Sbjct: 69  AAHCLRDIPQRLVNVVLGAHNVRTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQLSSPA 128

Query: 122 KPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRF 181
             S ++  + LP + Q V  GT+C   GWG        ++VL+EL++ V+ T  C     
Sbjct: 129 NLSASVATVQLPQQDQPVPHGTQCLAMGWGRVGAHDPPAQVLQELNVTVV-TFFCR---- 183

Query: 182 WNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATA 241
                 P  +C     +    C GDSGGPL+C    ++ G+ SF    C     P   T 
Sbjct: 184 ------PHNICTFVPRRKAGICFGDSGGPLIC--DGIIQGIDSFVIWGCATRLFPDFFTR 235

Query: 242 VAPYVSWIRKVTGR 255
           VA YV WIR    R
Sbjct: 236 VALYVDWIRSTLRR 249


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  136 bits (342), Expect = 2e-32
 Identities = 83/235 (35%), Positives = 129/235 (54%), Gaps = 11/235 (4%)

Query: 24  TQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCL----AQRMAQLRLVL 79
           ++I+GG+ V P   P+ AS+     H CGG ++ P+WV+TAAHC+      R++  R+  
Sbjct: 216 SRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHA 275

Query: 80  GL--HTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQ 137
           GL  H+   P     ++  I HP Y      + D+ALL+L   +  S T+  + LP+K Q
Sbjct: 276 GLVSHSAVRPHQGALVERIIPHPLYS-AQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQ 334

Query: 138 VVAAGTRCSMAGWGLTHQGGRLSR-VLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAAD 196
               G+RC ++GWG TH     S  +L++  + +  T++CN+S  ++G+L+P M+C    
Sbjct: 335 HFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYL 394

Query: 197 SKDQAPCKGDSGGPLVCGKGRV--LAGVLSFSSRVCTDIFKPPVATAVAPYVSWI 249
                 C+GDSGGPLVC  G    L GV+S+  R C +   P V   VA ++ WI
Sbjct: 395 DGRADACQGDSGGPLVCPDGDTWRLVGVVSW-GRGCAEPNHPGVYAKVAEFLDWI 448


>gi|11496281 kallikrein 13 precursor [Homo sapiens]
          Length = 277

 Score =  134 bits (338), Expect = 6e-32
 Identities = 92/261 (35%), Positives = 137/261 (52%), Gaps = 22/261 (8%)

Query: 5   VSSLLVLALGALSVGSSF-----GTQ--IIGGREVIPHSRPYMASLQRNGSHLCGGVLVH 57
           ++SL +   G +S  SS      GT   + GG    PHS+P+ A+L   G  LCGGVLVH
Sbjct: 8   IASLTLALSGGVSQESSKVLNTNGTSGFLPGGYTCFPHSQPWQAALLVQGRLLCGGVLVH 67

Query: 58  PKWVLTAAHCLAQRMAQLRLVLGLHTL---DSPGLTFHIKAAIQHPRYKPVPA---LEND 111
           PKWVLTAAHCL +    L++ LG H L   ++      +  +I HP Y+  P     ++D
Sbjct: 68  PKWVLTAAHCLKE---GLKVYLGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHD 124

Query: 112 LALLQLDGKVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGG-RLSRVLRELDLQV 170
           + LL+L   V+ +  I+ L L S    +  GT C ++GWG T        + L+  ++Q+
Sbjct: 125 IMLLELQSPVQLTGYIQTLPL-SHNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQL 183

Query: 171 LDTRMCNNSRFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVC 230
                C   + + G ++ +M+C       +  C+GDSGGPLVC   R L G++S+    C
Sbjct: 184 RSDEECR--QVYPGKITDNMLCAGTKEGGKDSCEGDSGGPLVC--NRTLYGIVSWGDFPC 239

Query: 231 TDIFKPPVATAVAPYVSWIRK 251
               +P V T V+ YV WIR+
Sbjct: 240 GQPDRPGVYTRVSRYVLWIRE 260


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  134 bits (337), Expect = 8e-32
 Identities = 83/236 (35%), Positives = 130/236 (55%), Gaps = 13/236 (5%)

Query: 25   QIIGGREVIPHSRPYMASLQRNGS-HLCGGVLVHPKWVLTAAHCLAQR--MAQLRLVLGL 81
            +I+GGR   P   P+  SLQ   S H+CG VL+  KWVLT AHC   R   A  ++VLG+
Sbjct: 801  RILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAAVWKVVLGI 860

Query: 82   HTLDSPGL---TFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQV 138
            + LD P +   T  +K  I HPRY     ++ D+++++L   +  +  +RP+ LP+  Q 
Sbjct: 861  NNLDHPSVFMQTRFVKTIILHPRYSRA-VVDYDISIVELSEDISETGYVRPVCLPNPEQW 919

Query: 139  VAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSK 198
            +   T C + GWG  H G ++   L+E +++++    C  S F   +++  M+C   +S 
Sbjct: 920  LEPDTYCYITGWG--HMGNKMPFKLQEGEVRIISLEHC-QSYFDMKTITTRMICAGYESG 976

Query: 199  DQAPCKGDSGGPLVCGK--GR-VLAGVLSFSSRVCTDIFKPPVATAVAPYVSWIRK 251
                C GDSGGPLVC K  GR  L G+ S+ S   + +  P V + V+ +V WI++
Sbjct: 977  TVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWIKR 1032


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  134 bits (336), Expect = 1e-31
 Identities = 81/240 (33%), Positives = 124/240 (51%), Gaps = 16/240 (6%)

Query: 25  QIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQR---MAQLRLVLGL 81
           +I+GGR+      P+  SL+ +G+HLCGG L+   WVLTAAHC  +R   +++ R+  G 
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA 221

Query: 82  HTLDSP-GLTFHIKAAIQHPRYKPV--PALE---NDLALLQLDGKVKPSRTIRPLALPSK 135
               SP GL   ++A + H  Y P   P  E   ND+AL+ L   +  +  I+P+ LP+ 
Sbjct: 222 VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAA 281

Query: 136 RQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAA 195
            Q +  G  C++ GWG T   G+ + VL+E  + ++   +CN + F+   + P M C   
Sbjct: 282 GQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGY 341

Query: 196 DSKDQAPCKGDSGGPLVCGKGRV------LAGVLSFSSRVCTDIFKPPVATAVAPYVSWI 249
                  C+GDSGGP VC           L G++S+ +  C    KP V T V+ +  WI
Sbjct: 342 PEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTG-CALAQKPGVYTKVSDFREWI 400


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  134 bits (336), Expect = 1e-31
 Identities = 81/240 (33%), Positives = 124/240 (51%), Gaps = 16/240 (6%)

Query: 25  QIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQR---MAQLRLVLGL 81
           +I+GGR+      P+  SL+ +G+HLCGG L+   WVLTAAHC  +R   +++ R+  G 
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA 221

Query: 82  HTLDSP-GLTFHIKAAIQHPRYKPV--PALE---NDLALLQLDGKVKPSRTIRPLALPSK 135
               SP GL   ++A + H  Y P   P  E   ND+AL+ L   +  +  I+P+ LP+ 
Sbjct: 222 VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAA 281

Query: 136 RQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAA 195
            Q +  G  C++ GWG T   G+ + VL+E  + ++   +CN + F+   + P M C   
Sbjct: 282 GQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGY 341

Query: 196 DSKDQAPCKGDSGGPLVCGKGRV------LAGVLSFSSRVCTDIFKPPVATAVAPYVSWI 249
                  C+GDSGGP VC           L G++S+ +  C    KP V T V+ +  WI
Sbjct: 342 PEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTG-CALAQKPGVYTKVSDFREWI 400


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  132 bits (332), Expect = 3e-31
 Identities = 87/233 (37%), Positives = 125/233 (53%), Gaps = 11/233 (4%)

Query: 25  QIIGGREVIPHSRPYMASLQ-RNGSHLCGGVLVHPKWVLTAAHCLAQ--RMAQLRLVLGL 81
           +++GG    PHS P+  SL+ R G H CGG L+ P+WVLTAAHCL +  R +  +++LG 
Sbjct: 580 RVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGA 639

Query: 82  HTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVVAA 141
           H      L  H++  I+  R    P    D+ALL+L      +  + P  LPS   VVA 
Sbjct: 640 H--QEVNLEPHVQE-IEVSRLFLEPT-RKDIALLKLSSPAVITDKVIPACLPSPNYVVAD 695

Query: 142 GTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSKDQA 201
            T C + GWG T QG   + +L+E  L V++ ++CN   F NG +  + +C    +    
Sbjct: 696 RTECFITGWGET-QGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTD 754

Query: 202 PCKGDSGGPLVCGK--GRVLAGVLSFSSRVCTDIFKPPVATAVAPYVSWIRKV 252
            C+GDSGGPLVC +    +L GV S+    C    KP V   V+ +V+WI  V
Sbjct: 755 SCQGDSGGPLVCFEKDKYILQGVTSWGLG-CARPNKPGVYVRVSRFVTWIEGV 806


>gi|6005844 kallikrein 8 isoform 1 preproprotein [Homo sapiens]
          Length = 260

 Score =  130 bits (328), Expect = 9e-31
 Identities = 87/255 (34%), Positives = 130/255 (50%), Gaps = 18/255 (7%)

Query: 8   LLVLALGALSVGSSFGTQ--IIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAA 65
           + +L LG    G S   +  ++GG E  PHS+P+ A+L +    LCGGVLV   WVLTAA
Sbjct: 13  MFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAA 72

Query: 66  HCLAQRMAQLRLVLGLHTL---DSPGLTFHIKAAIQHPRY--KPVPALENDLALLQLDGK 120
           HC   +  +  + LG H+L   D P     +  +I HP Y    V    +DL LLQL  +
Sbjct: 73  HC---KKPKYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQ 129

Query: 121 VKPSRTIRPLALPSKRQVVAAGTRCSMAGWG-LTHQGGRLSRVLRELDLQVLDTRMCNNS 179
                 ++P++L         G +C+++GWG +T         L   ++++   + C ++
Sbjct: 130 ASLGSKVKPISLAD--HCTQPGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDA 187

Query: 180 RFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVA 239
             + G ++  MVC A  SK    C+GDSGGPLVC     L G+ S+ S  C    KP V 
Sbjct: 188 --YPGQITDGMVC-AGSSKGADTCQGDSGGPLVC--DGALQGITSWGSDPCGRSDKPGVY 242

Query: 240 TAVAPYVSWIRKVTG 254
           T +  Y+ WI+K+ G
Sbjct: 243 TNICRYLDWIKKIIG 257


>gi|58331209 chymotrypsin-like elastase family, member 1 [Homo
           sapiens]
          Length = 258

 Score =  130 bits (326), Expect = 1e-30
 Identities = 87/240 (36%), Positives = 129/240 (53%), Gaps = 15/240 (6%)

Query: 25  QIIGGREVIPHSRPYMASLQ-RNGS---HLCGGVLVHPKWVLTAAHCLAQRMAQLRLVLG 80
           +++GG E   +S P   SLQ R+G    H CGG L+   WV+TAAHC+  +    R+V G
Sbjct: 18  RVVGGTEAGRNSWPSQISLQYRSGGSRYHTCGGTLIRQNWVMTAAHCVDYQKT-FRVVAG 76

Query: 81  LHTL---DSPGLTFHIKAAIQHPRYKPVP-ALENDLALLQLDGKVKPSRTIRPLALPSKR 136
            H L   D       ++  + HP +     A   D+ALL+L   V  +  ++   LP + 
Sbjct: 77  DHNLSQNDGTEQYVSVQKIVVHPYWNSDNVAAGYDIALLRLAQSVTLNSYVQLGVLPQEG 136

Query: 137 QVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAAD 196
            ++A  + C + GWG T   G+L++ L++  L  +D  +C++S +W  ++  +MVC   D
Sbjct: 137 AILANNSPCYITGWGKTKTNGQLAQTLQQAYLPSVDYAICSSSSYWGSTVKNTMVCAGGD 196

Query: 197 SKDQAPCKGDSGGPLVC---GKGRVLAGVLSF-SSRVCTDIFKPPVATAVAPYVSWIRKV 252
              ++ C+GDSGGPL C   GK  V  GV SF SSR C    KP V T V+ Y+SWI  V
Sbjct: 197 GV-RSGCQGDSGGPLHCLVNGKYSV-HGVTSFVSSRGCNVSRKPTVFTQVSAYISWINNV 254


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  129 bits (325), Expect = 2e-30
 Identities = 74/252 (29%), Positives = 132/252 (52%), Gaps = 10/252 (3%)

Query: 5   VSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTA 64
           V SL  +A G +++ SS  ++I+GG   +P + P+  SL     H+CGG ++ P+W++TA
Sbjct: 273 VVSLRCIACG-VNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTA 331

Query: 65  AHCLAQRMAQ---LRLVLGL--HTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDG 119
           AHC+ + +          G+   +    G  + ++  I HP Y       ND+AL++L  
Sbjct: 332 AHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDS-KTKNNDIALMKLQK 390

Query: 120 KVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNS 179
            +  +  ++P+ LP+   ++     C ++GWG T + G+ S VL    + +++T+ CN+ 
Sbjct: 391 PLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSR 450

Query: 180 RFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRV--LAGVLSFSSRVCTDIFKPP 237
             ++  ++P+M+C      +   C+GDSGGPLV  K  +  L G  S+ S  C   ++P 
Sbjct: 451 YVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSG-CAKAYRPG 509

Query: 238 VATAVAPYVSWI 249
           V   V  +  WI
Sbjct: 510 VYGNVMVFTDWI 521


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  129 bits (325), Expect = 2e-30
 Identities = 74/252 (29%), Positives = 132/252 (52%), Gaps = 10/252 (3%)

Query: 5   VSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTA 64
           V SL  +A G +++ SS  ++I+GG   +P + P+  SL     H+CGG ++ P+W++TA
Sbjct: 236 VVSLRCIACG-VNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTA 294

Query: 65  AHCLAQRMAQ---LRLVLGL--HTLDSPGLTFHIKAAIQHPRYKPVPALENDLALLQLDG 119
           AHC+ + +          G+   +    G  + ++  I HP Y       ND+AL++L  
Sbjct: 295 AHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDS-KTKNNDIALMKLQK 353

Query: 120 KVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNS 179
            +  +  ++P+ LP+   ++     C ++GWG T + G+ S VL    + +++T+ CN+ 
Sbjct: 354 PLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSR 413

Query: 180 RFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRV--LAGVLSFSSRVCTDIFKPP 237
             ++  ++P+M+C      +   C+GDSGGPLV  K  +  L G  S+ S  C   ++P 
Sbjct: 414 YVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSG-CAKAYRPG 472

Query: 238 VATAVAPYVSWI 249
           V   V  +  WI
Sbjct: 473 VYGNVMVFTDWI 484


>gi|11342670 azurocidin 1 preproprotein [Homo sapiens]
          Length = 251

 Score =  129 bits (323), Expect = 3e-30
 Identities = 92/250 (36%), Positives = 123/250 (49%), Gaps = 21/250 (8%)

Query: 5   VSSLLVLALGALSVGSSFGTQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTA 64
           V +LL   L +   GSS    I+GGR+  P   P++AS+Q  G H CGG L+H ++V+TA
Sbjct: 6   VLALLAGLLASSRAGSSPLLDIVGGRKARPRQFPFLASIQNQGRHFCGGALIHARFVMTA 65

Query: 65  AHCL-AQRMAQLRLVLGLHTLD----SPGLTFHIKAAIQHPRYKPVPALENDLALLQLDG 119
           A C  +Q      +VLG + L         TF I +  ++  Y P   L NDL LLQLD 
Sbjct: 66  ASCFQSQNPGVSTVVLGAYDLRRRERQSRQTFSISSMSENG-YDPQQNL-NDLMLLQLDR 123

Query: 120 KVKPSRTIRPLALPSKRQVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNS 179
           +   + ++  L LP +   V AGTRC +AGWG    GGRLSR  R +++ V     C   
Sbjct: 124 EANLTSSVTILPLPLQNATVEAGTRCQVAGWGSQRSGGRLSRFPRFVNVTVTPEDQCR-- 181

Query: 180 RFWNGSLSPSMVCLAADSKDQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVA 239
                   P+ VC    ++    C GD G PLVC    +  GV SFS   C     P   
Sbjct: 182 --------PNNVCTGVLTRRGGICNGDGGTPLVC--EGLAHGVASFSLGPCGR--GPDFF 229

Query: 240 TAVAPYVSWI 249
           T VA +  WI
Sbjct: 230 TRVALFRDWI 239


>gi|21464127 kallikrein 8 isoform 2 [Homo sapiens]
          Length = 305

 Score =  129 bits (323), Expect = 3e-30
 Identities = 82/236 (34%), Positives = 123/236 (52%), Gaps = 16/236 (6%)

Query: 25  QIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQRMAQLRLVLGLHTL 84
           +++GG E  PHS+P+ A+L +    LCGGVLV   WVLTAAHC   +  +  + LG H+L
Sbjct: 77  KVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHC---KKPKYTVRLGDHSL 133

Query: 85  ---DSPGLTFHIKAAIQHPRY--KPVPALENDLALLQLDGKVKPSRTIRPLALPSKRQVV 139
              D P     +  +I HP Y    V    +DL LLQL  +      ++P++L       
Sbjct: 134 QNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLAD--HCT 191

Query: 140 AAGTRCSMAGWG-LTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAADSK 198
             G +C+++GWG +T         L   ++++   + C ++  + G ++  MVC A  SK
Sbjct: 192 QPGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDA--YPGQITDGMVC-AGSSK 248

Query: 199 DQAPCKGDSGGPLVCGKGRVLAGVLSFSSRVCTDIFKPPVATAVAPYVSWIRKVTG 254
               C+GDSGGPLVC     L G+ S+ S  C    KP V T +  Y+ WI+K+ G
Sbjct: 249 GADTCQGDSGGPLVC--DGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKKIIG 302


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  129 bits (323), Expect = 3e-30
 Identities = 85/239 (35%), Positives = 129/239 (53%), Gaps = 14/239 (5%)

Query: 24  TQIIGGREVIPHSRPYMASLQRNGSHLCGGVLVHPKWVLTAAHCLAQ-RMAQLRL---VL 79
           ++I+GG        P+ ASLQ  G H+CGG L+  +WV+TAAHC  +  MA   L    L
Sbjct: 575 SRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFL 634

Query: 80  GLHTLDS--PG-LTFHIKAAIQHPRYKPVPALENDLALLQLDGKVKPSRTIRPLALPSKR 136
           G    +S  PG ++F +   + HP Y    + + D+ALLQLD  V  S  +RP+ LP++ 
Sbjct: 635 GKVWQNSRWPGEVSFKVSRLLLHP-YHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARS 693

Query: 137 QVVAAGTRCSMAGWGLTHQGGRLSRVLRELDLQVLDTRMCNNSRFWNGSLSPSMVCLAAD 196
                G  C + GWG   +GG +S  L+++D+Q++   +C  S  +   ++P M+C    
Sbjct: 694 HFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLC--SEVYRYQVTPRMLCAGYR 751

Query: 197 SKDQAPCKGDSGGPLVCG--KGR-VLAGVLSFSSRVCTDIFKPPVATAVAPYVSWIRKV 252
              +  C+GDSGGPLVC    GR  LAG++S+    C       V T +   +SWI++V
Sbjct: 752 KGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLG-CGRPNYFGVYTRITGVISWIQQV 809


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,275,050
Number of Sequences: 37866
Number of extensions: 456655
Number of successful extensions: 1422
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 160
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 880
Number of HSP's gapped (non-prelim): 191
length of query: 257
length of database: 18,247,518
effective HSP length: 100
effective length of query: 157
effective length of database: 14,460,918
effective search space: 2270364126
effective search space used: 2270364126
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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