Search of human proteins with 4885235

Search of human proteins with 4885235

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
         (529 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...  1093   0.0  
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...  1093   0.0  
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...  1093   0.0  
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      774   0.0  
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       758   0.0  
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              752   0.0  
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   716   0.0  
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   716   0.0  
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]      690   0.0  
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]     582   e-166
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   556   e-158
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...   556   e-158
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...   553   e-157
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...   553   e-157
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                 545   e-155
gi|4503787 fyn-related kinase [Homo sapiens]                          462   e-130
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   364   e-101
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   364   e-101
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             364   e-101
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               364   e-100
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             363   e-100
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             363   e-100
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             363   e-100
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   359   3e-99
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]              357   2e-98
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       320   2e-87
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]   310   3e-84
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               309   5e-84
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                305   9e-83
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     285   6e-77

>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score = 1093 bits (2826), Expect = 0.0
 Identities = 529/529 (100%), Positives = 529/529 (100%)

Query: 1   MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA 60
           MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA
Sbjct: 1   MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA 60

Query: 61  INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120
           INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL
Sbjct: 61  INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120

Query: 121 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180
           SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY
Sbjct: 121 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180

Query: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP 240
           SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP
Sbjct: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP 240

Query: 241 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP 300
           CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP
Sbjct: 241 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP 300

Query: 301 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV 360
           KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV
Sbjct: 301 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV 360

Query: 361 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF 420
           DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF
Sbjct: 361 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF 420

Query: 421 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP 480
           PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP
Sbjct: 421 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP 480

Query: 481 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT 529
           PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
Sbjct: 481 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT 529


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score = 1093 bits (2826), Expect = 0.0
 Identities = 529/529 (100%), Positives = 529/529 (100%)

Query: 1   MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA 60
           MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA
Sbjct: 1   MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA 60

Query: 61  INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120
           INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL
Sbjct: 61  INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120

Query: 121 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180
           SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY
Sbjct: 121 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180

Query: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP 240
           SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP
Sbjct: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP 240

Query: 241 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP 300
           CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP
Sbjct: 241 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP 300

Query: 301 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV 360
           KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV
Sbjct: 301 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV 360

Query: 361 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF 420
           DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF
Sbjct: 361 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF 420

Query: 421 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP 480
           PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP
Sbjct: 421 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP 480

Query: 481 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT 529
           PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
Sbjct: 481 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT 529


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score = 1093 bits (2826), Expect = 0.0
 Identities = 529/529 (100%), Positives = 529/529 (100%)

Query: 1   MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA 60
           MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA
Sbjct: 1   MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKARPASSFAHIPNYSNFSSQA 60

Query: 61  INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120
           INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL
Sbjct: 61  INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSL 120

Query: 121 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180
           SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY
Sbjct: 121 SSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAY 180

Query: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP 240
           SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP
Sbjct: 181 SLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAP 240

Query: 241 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP 300
           CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP
Sbjct: 241 CTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSP 300

Query: 301 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV 360
           KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV
Sbjct: 301 KAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLV 360

Query: 361 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF 420
           DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF
Sbjct: 361 DMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKF 420

Query: 421 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP 480
           PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP
Sbjct: 421 PIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCP 480

Query: 481 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT 529
           PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT
Sbjct: 481 PGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGDQT 529


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  774 bits (1998), Expect = 0.0
 Identities = 383/537 (71%), Positives = 433/537 (80%), Gaps = 15/537 (2%)

Query: 1   MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59
           MGCV CK  E     +E  G       Y     YG DPT    P+     IPNY+NF + 
Sbjct: 1   MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56

Query: 60  A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110
                     +N     +GT+R   G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++
Sbjct: 57  GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115

Query: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170
           EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI
Sbjct: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175

Query: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230
           RESETTKGAYSLSIRDWD  +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY E  
Sbjct: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKA 235

Query: 231 DGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAV 290
           DGLC  L    +   PQT GLAKDAWE++R S+ LE++LG GCF +VWLGTWNG+TKVA+
Sbjct: 236 DGLCFNLTVIASSCTPQTSGLAKDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAI 295

Query: 291 KTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPE 350
           KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M  GSLLDFLK+ E
Sbjct: 296 KTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGE 355

Query: 351 GQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDD 410
           G+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG  L CKIADFGLARLI+D+
Sbjct: 356 GRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDN 415

Query: 411 EYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQ 470
           EY   QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REVLEQ
Sbjct: 416 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQ 475

Query: 471 VEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
           VE+GY MPCP  CP SL+E M   W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+
Sbjct: 476 VERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 532


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  758 bits (1958), Expect = 0.0
 Identities = 379/540 (70%), Positives = 429/540 (79%), Gaps = 18/540 (3%)

Query: 1   MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59
           MGCV CK  E     +E  G       Y     YG DPT    P+     IPNY+NF + 
Sbjct: 1   MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56

Query: 60  A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110
                     +N     +GT+R   G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++
Sbjct: 57  GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115

Query: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170
           EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI
Sbjct: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175

Query: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230
           RESETTKGAYSLSIRDWD  +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY E  
Sbjct: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERA 235

Query: 231 DGLCNLLIAPCTIMKPQTLGLA---KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTK 287
            GLC  L+ PC    P+   L+   KD WEI R S+ L +RLG G FG+VW+GTWNG+TK
Sbjct: 236 AGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTK 295

Query: 288 VAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLK 347
           VA+KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M  GSLLDFLK
Sbjct: 296 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLK 355

Query: 348 NPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLI 407
           + EG+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG  L CKIADFGLARLI
Sbjct: 356 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLI 415

Query: 408 KDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREV 467
           +D+EY   QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REV
Sbjct: 416 EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREV 475

Query: 468 LEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
           LEQVE+GY MPCP  CP SL+E M   W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+
Sbjct: 476 LEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 535


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  752 bits (1942), Expect = 0.0
 Identities = 364/515 (70%), Positives = 421/515 (81%), Gaps = 18/515 (3%)

Query: 30  AADHYGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTI-----------------R 72
           +  HYG +PT   P  S +      NFSS ++ P    SG                    
Sbjct: 28  SVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPA 87

Query: 73  GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNY 132
           G++G GVT+F+ALYDYEART +DL+F KGE+F I+NNTEGDWWEARS+++GK G IPSNY
Sbjct: 88  GLTG-GVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNY 146

Query: 133 VAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRG 192
           VAP DSIQAEEWYFGK+GRKDAER LL+PGN +G FL+RESETTKGAYSLSIRDWD+ RG
Sbjct: 147 VAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRG 206

Query: 193 DHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLA 252
           D+VKHYKIRKLD GGYYITTR QF+++Q+LV+HY E  DGLC+ L   C  +KPQT GLA
Sbjct: 207 DNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLA 266

Query: 253 KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKL 312
           KDAWEI R S+ LE +LG GCFG+VW+GTWNG+TKVA+KTLKPGTM P+AFL+EAQ+MK 
Sbjct: 267 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKK 326

Query: 313 LRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAY 372
           LRHDKLV LYAVVSEEPIYIVTEFM  GSLLDFLK  +G+ L+LPQLVDMAAQ+A+GMAY
Sbjct: 327 LRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAY 386

Query: 373 MERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALF 432
           +ERMNYIHRDLRAANILVGE L CKIADFGLARLI+D+EY   QG+KFPIKWTAPEAAL+
Sbjct: 387 IERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 446

Query: 433 GRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAME 492
           GRFTIKSDVWSFGIL TEL+TKGR+PYPGM  REVLEQVE+GY MPCP GCP SL+E M 
Sbjct: 447 GRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMN 506

Query: 493 QTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
             W+ DP+ERPTFEY+QSFLEDYFT+ EPQYQPG+
Sbjct: 507 LCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGE 541


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  716 bits (1848), Expect = 0.0
 Identities = 356/530 (67%), Positives = 418/530 (78%), Gaps = 10/530 (1%)

Query: 8   KLEPVATAKEDAGLEGDFRSYGAADHYGP-DPTKARPASSFAHIPNYSNFSSQAINP--- 63
           K +P   ++    LE     +GA     P   T ++PAS+  H    + F+  A  P   
Sbjct: 5   KSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLF 64

Query: 64  -GFLDSGTIR-----GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117
            GF  S T+      G    GVT F+ALYDYE+RTE DL+F KGE+  I+NNTEGDWW A
Sbjct: 65  GGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLA 124

Query: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177
            SLS+G+TG IPSNYVAP DSIQAEEWYFGKI R+++ER LL+  NP+G FL+RESETTK
Sbjct: 125 HSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184

Query: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237
           GAY LS+ D+D  +G +VKHYKIRKLD GG+YIT+R QFNS+Q+LV +Y +  DGLC+ L
Sbjct: 185 GAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL 244

Query: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297
              C   KPQT GLAKDAWEI R S+ LE +LG GCFG+VW+GTWNG+T+VA+KTLKPGT
Sbjct: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT 304

Query: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357
           MSP+AFL+EAQVMK LRH+KLVQLYAVVSEEPIYIVTE+M  GSLLDFLK   G+ LRLP
Sbjct: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364

Query: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417
           QLVDMAAQ+A GMAY+ERMNY+HRDLRAANILVGE L CK+ADFGLARLI+D+EY   QG
Sbjct: 365 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 424

Query: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477
           +KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL TKGR+PYPGM  REVL+QVE+GY M
Sbjct: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484

Query: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
           PCPP CP SL++ M Q WR +PEERPTFEYLQ+FLEDYFTS EPQYQPG+
Sbjct: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  716 bits (1848), Expect = 0.0
 Identities = 356/530 (67%), Positives = 418/530 (78%), Gaps = 10/530 (1%)

Query: 8   KLEPVATAKEDAGLEGDFRSYGAADHYGP-DPTKARPASSFAHIPNYSNFSSQAINP--- 63
           K +P   ++    LE     +GA     P   T ++PAS+  H    + F+  A  P   
Sbjct: 5   KSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLF 64

Query: 64  -GFLDSGTIR-----GVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117
            GF  S T+      G    GVT F+ALYDYE+RTE DL+F KGE+  I+NNTEGDWW A
Sbjct: 65  GGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLA 124

Query: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177
            SLS+G+TG IPSNYVAP DSIQAEEWYFGKI R+++ER LL+  NP+G FL+RESETTK
Sbjct: 125 HSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK 184

Query: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237
           GAY LS+ D+D  +G +VKHYKIRKLD GG+YIT+R QFNS+Q+LV +Y +  DGLC+ L
Sbjct: 185 GAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL 244

Query: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297
              C   KPQT GLAKDAWEI R S+ LE +LG GCFG+VW+GTWNG+T+VA+KTLKPGT
Sbjct: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT 304

Query: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357
           MSP+AFL+EAQVMK LRH+KLVQLYAVVSEEPIYIVTE+M  GSLLDFLK   G+ LRLP
Sbjct: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364

Query: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417
           QLVDMAAQ+A GMAY+ERMNY+HRDLRAANILVGE L CK+ADFGLARLI+D+EY   QG
Sbjct: 365 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 424

Query: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477
           +KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL TKGR+PYPGM  REVL+QVE+GY M
Sbjct: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484

Query: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
           PCPP CP SL++ M Q WR +PEERPTFEYLQ+FLEDYFTS EPQYQPG+
Sbjct: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534


>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
          Length = 482

 Score =  690 bits (1781), Expect = 0.0
 Identities = 354/537 (65%), Positives = 397/537 (73%), Gaps = 67/537 (12%)

Query: 1   MGCVFCKKLEPVATAKEDAGLEGDFRSYGAADHYGPDPTKAR-PASSFAHIPNYSNFSSQ 59
           MGCV CK  E     +E  G       Y     YG DPT    P+     IPNY+NF + 
Sbjct: 1   MGCVQCKDKEATKLTEERDGSLNQSSGY----RYGTDPTPQHYPSFGVTSIPNYNNFHAA 56

Query: 60  A---------INPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNT 110
                     +N     +GT+R   G GVTLF+ALYDYEARTEDDL+F KGEKF ILN++
Sbjct: 57  GGQGLTVFGGVNSSS-HTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSS 115

Query: 111 EGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLI 170
           EGDWWEARSL++G+TG IPSNYVAPVDSIQAEEWYFGK+GRKDAERQLLS GNP+G FLI
Sbjct: 116 EGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLI 175

Query: 171 RESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVN 230
           RESETTKGAYSLSIRDWD  +GDHVKHYKIRKLD GGYYITTR QF ++Q+LVQHY    
Sbjct: 176 RESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS--- 232

Query: 231 DGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAV 290
                                                            GTWNG+TKVA+
Sbjct: 233 -------------------------------------------------GTWNGNTKVAI 243

Query: 291 KTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPE 350
           KTLKPGTMSP++FLEEAQ+MK L+HDKLVQLYAVVSEEPIYIVTE+M  GSLLDFLK+ E
Sbjct: 244 KTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGE 303

Query: 351 GQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDD 410
           G+ L+LP LVDMAAQVA GMAY+ERMNYIHRDLR+ANILVG  L CKIADFGLARLI+D+
Sbjct: 304 GRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDN 363

Query: 411 EYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQ 470
           EY   QG+KFPIKWTAPEAAL+GRFTIKSDVWSFGILLTEL+TKGR+PYPGMN REVLEQ
Sbjct: 364 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQ 423

Query: 471 VEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQPGD 527
           VE+GY MPCP  CP SL+E M   W+ DPEERPTFEYLQSFLEDYFT+ EPQYQPG+
Sbjct: 424 VERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGE 480


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score =  582 bits (1499), Expect = e-166
 Identities = 291/491 (59%), Positives = 367/491 (74%), Gaps = 18/491 (3%)

Query: 34  YGPDPTKARPASSFAHIPNYSNFSSQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTE 93
           Y PDPT     S+    PN  N ++    PG  ++G+          + +ALYDYEA   
Sbjct: 51  YVPDPT-----STIKPGPNSHNSNT----PGIREAGSED-------IIVVALYDYEAIHH 94

Query: 94  DDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKD 153
           +DL+F KG++  +L  + G+WW+ARSL++ K G IPSNYVA VDS++ EEW+F  I RKD
Sbjct: 95  EDLSFQKGDQMVVLEES-GEWWKARSLATRKEGYIPSNYVARVDSLETEEWFFKGISRKD 153

Query: 154 AERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTR 213
           AERQLL+PGN  G+F+IR+SETTKG+YSLS+RD+D  +GD VKHYKIR LD GG+YI+ R
Sbjct: 154 AERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPR 213

Query: 214 VQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGC 273
             F+++QELV HY + NDGLC  L  PC   KPQ     KDAWEI R S+ LE++LG G 
Sbjct: 214 STFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQK-PWEKDAWEIPRESLKLEKKLGAGQ 272

Query: 274 FGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIV 333
           FG+VW+ T+N  TKVAVKT+KPG+MS +AFL EA VMK L+HDKLV+L+AVV++EPIYI+
Sbjct: 273 FGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYII 332

Query: 334 TEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGER 393
           TEFM  GSLLDFLK+ EG    LP+L+D +AQ+AEGMA++E+ NYIHRDLRAANILV   
Sbjct: 333 TEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSAS 392

Query: 394 LACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELIT 453
           L CKIADFGLAR+I+D+EY   +G+KFPIKWTAPEA  FG FTIKSDVWSFGILL E++T
Sbjct: 393 LVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVT 452

Query: 454 KGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLE 513
            GRIPYPGM+  EV+  +E+GY MP P  CP  LY  M + W+  PEERPTFEY+QS L+
Sbjct: 453 YGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQSVLD 512

Query: 514 DYFTSAEPQYQ 524
           D++T+ E QYQ
Sbjct: 513 DFYTATESQYQ 523


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  556 bits (1434), Expect = e-158
 Identities = 272/445 (61%), Positives = 339/445 (76%), Gaps = 3/445 (0%)

Query: 81  LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQ 140
           + +ALY Y+    DDL+F KGEK  +L    G+WW+A+SL + K G IPSNYVA +++++
Sbjct: 46  IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 104

Query: 141 AEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI 200
            EEW+F  I RKDAERQLL+PGN  GAFLIRESET KG++SLS+RD+D   GD +KHYKI
Sbjct: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 164

Query: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISR 260
           R LD GGYYI+ R+ F  + ++++HY +  DGLC  L   C   KPQ     KDAWEI R
Sbjct: 165 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK-PWDKDAWEIPR 223

Query: 261 SSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ 320
            SI L +RLG G FG+VW+G +N STKVAVKTLKPGTMS +AFLEEA +MK L+HDKLV+
Sbjct: 224 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 283

Query: 321 LYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYI 379
           LYAVV+ EEPIYI+TE+M  GSLLDFLK+ EG  + LP+L+D +AQ+AEGMAY+ER NYI
Sbjct: 284 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 343

Query: 380 HRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKS 439
           HRDLRAAN+LV E L CKIADFGLAR+I+D+EY   +G+KFPIKWTAPEA  FG FTIKS
Sbjct: 344 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 403

Query: 440 DVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDP 499
           DVWSFGILL E++T G+IPYPG    +V+  + QGY MP    CP  LY+ M+  W+   
Sbjct: 404 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 463

Query: 500 EERPTFEYLQSFLEDYFTSAEPQYQ 524
           EERPTF+YLQS L+D++T+ E QYQ
Sbjct: 464 EERPTFDYLQSVLDDFYTATEGQYQ 488


>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score =  556 bits (1434), Expect = e-158
 Identities = 272/445 (61%), Positives = 339/445 (76%), Gaps = 3/445 (0%)

Query: 81  LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQ 140
           + +ALY Y+    DDL+F KGEK  +L    G+WW+A+SL + K G IPSNYVA +++++
Sbjct: 67  IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125

Query: 141 AEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI 200
            EEW+F  I RKDAERQLL+PGN  GAFLIRESET KG++SLS+RD+D   GD +KHYKI
Sbjct: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 185

Query: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISR 260
           R LD GGYYI+ R+ F  + ++++HY +  DGLC  L   C   KPQ     KDAWEI R
Sbjct: 186 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK-PWDKDAWEIPR 244

Query: 261 SSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ 320
            SI L +RLG G FG+VW+G +N STKVAVKTLKPGTMS +AFLEEA +MK L+HDKLV+
Sbjct: 245 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 304

Query: 321 LYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYI 379
           LYAVV+ EEPIYI+TE+M  GSLLDFLK+ EG  + LP+L+D +AQ+AEGMAY+ER NYI
Sbjct: 305 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 364

Query: 380 HRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKS 439
           HRDLRAAN+LV E L CKIADFGLAR+I+D+EY   +G+KFPIKWTAPEA  FG FTIKS
Sbjct: 365 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 424

Query: 440 DVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDP 499
           DVWSFGILL E++T G+IPYPG    +V+  + QGY MP    CP  LY+ M+  W+   
Sbjct: 425 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 484

Query: 500 EERPTFEYLQSFLEDYFTSAEPQYQ 524
           EERPTF+YLQS L+D++T+ E QYQ
Sbjct: 485 EERPTFDYLQSVLDDFYTATEGQYQ 509


>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  553 bits (1426), Expect = e-157
 Identities = 269/468 (57%), Positives = 349/468 (74%), Gaps = 2/468 (0%)

Query: 58  SQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117
           S+  +P     G+    S +   L IAL+ YE   + DL F KGE+  IL  + G+WW+A
Sbjct: 42  SEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKA 100

Query: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177
           +SL++G+ G IP N+VA  +S++ E W+F  + RKDAERQLL+PGN  G+FLIRESE+T 
Sbjct: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160

Query: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237
           G++SLS+RD+DQ +G+ VKHYKIR LD GG+YI+ R+ F  + ELV+HY   +DGLC  L
Sbjct: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220

Query: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297
             PC   KPQ     +D WE+ R ++ L  RLG G FG+VW+G +NG TKVAVK+LK G+
Sbjct: 221 SRPCQTQKPQKPWW-EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGS 279

Query: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357
           MSP AFL EA +MK L+H +LV+LYAVV++EPIYI+TE+M +GSL+DFLK P G  L + 
Sbjct: 280 MSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTIN 339

Query: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417
           +L+DMAAQ+AEGMA++E  NYIHRDLRAANILV + L+CKIADFGLARLI+D+EY   +G
Sbjct: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399

Query: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477
           +KFPIKWTAPEA  +G FTIKSDVWSFGILLTE++T GRIPYPGM   EV++ +E+GY M
Sbjct: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459

Query: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQP 525
             P  CP  LY+ M   W+  PE+RPTF+YL+S LED+FT+ E QYQP
Sbjct: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  553 bits (1426), Expect = e-157
 Identities = 269/468 (57%), Positives = 349/468 (74%), Gaps = 2/468 (0%)

Query: 58  SQAINPGFLDSGTIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEA 117
           S+  +P     G+    S +   L IAL+ YE   + DL F KGE+  IL  + G+WW+A
Sbjct: 42  SEVRDPLVTYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQS-GEWWKA 100

Query: 118 RSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTK 177
           +SL++G+ G IP N+VA  +S++ E W+F  + RKDAERQLL+PGN  G+FLIRESE+T 
Sbjct: 101 QSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA 160

Query: 178 GAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLL 237
           G++SLS+RD+DQ +G+ VKHYKIR LD GG+YI+ R+ F  + ELV+HY   +DGLC  L
Sbjct: 161 GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRL 220

Query: 238 IAPCTIMKPQTLGLAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGT 297
             PC   KPQ     +D WE+ R ++ L  RLG G FG+VW+G +NG TKVAVK+LK G+
Sbjct: 221 SRPCQTQKPQKPWW-EDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGS 279

Query: 298 MSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLP 357
           MSP AFL EA +MK L+H +LV+LYAVV++EPIYI+TE+M +GSL+DFLK P G  L + 
Sbjct: 280 MSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTIN 339

Query: 358 QLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQG 417
           +L+DMAAQ+AEGMA++E  NYIHRDLRAANILV + L+CKIADFGLARLI+D+EY   +G
Sbjct: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399

Query: 418 SKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHM 477
           +KFPIKWTAPEA  +G FTIKSDVWSFGILLTE++T GRIPYPGM   EV++ +E+GY M
Sbjct: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459

Query: 478 PCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQP 525
             P  CP  LY+ M   W+  PE+RPTF+YL+S LED+FT+ E QYQP
Sbjct: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 507


>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score =  545 bits (1403), Expect = e-155
 Identities = 271/443 (61%), Positives = 336/443 (75%), Gaps = 5/443 (1%)

Query: 83  IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
           +ALYDY A  + DL   KGEK  +L  T GDWW ARSL +G+ G +PSN+VA V+S++ E
Sbjct: 64  VALYDYTAMNDRDLQMLKGEKLQVLKGT-GDWWLARSLVTGREGYVPSNFVARVESLEME 122

Query: 143 EWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRK 202
            W+F   GRK+AERQLL+P N  G+FLIRESET KGA+SLS++D   T+G+ +KHYKIR 
Sbjct: 123 RWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQGELIKHYKIRC 181

Query: 203 LDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISRSS 262
           LD GGYYI+ R+ F S+Q LVQHY +  DGLC  L  PC    PQ    A+D WEI R S
Sbjct: 182 LDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQN-PWAQDEWEIPRQS 240

Query: 263 ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLY 322
           + L R+LG+G FG+VW+G +  + KVA+KTLK GTMSP+AFL EA VMK L+H++LV+LY
Sbjct: 241 LRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLY 300

Query: 323 AVVSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRD 382
           AVV++EPIYIVTE+M  G LLDFLK  EG  L LP+L+DM+AQ+AEGMAY+ERMN IHRD
Sbjct: 301 AVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRD 360

Query: 383 LRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVW 442
           LRAANILV E L CKIADFGLAR+I D EY   +G+KFPIKWTAPEA  FG FTIK+DVW
Sbjct: 361 LRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVW 419

Query: 443 SFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYE-AMEQTWRLDPEE 501
           SFG+LL E++T GR+PYPGM+  EV+  +E+GY MP P  CP  LY   + + WR  PEE
Sbjct: 420 SFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEE 479

Query: 502 RPTFEYLQSFLEDYFTSAEPQYQ 524
           RPTFE+LQS LED++T+ E QY+
Sbjct: 480 RPTFEFLQSVLEDFYTATERQYE 502


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  462 bits (1189), Expect = e-130
 Identities = 240/450 (53%), Positives = 303/450 (67%), Gaps = 20/450 (4%)

Query: 82  FIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGC-------IPSNYVA 134
           F+AL+DY+ART +DL+F  G+K  +L+     WW AR L   + G        IPSNYVA
Sbjct: 47  FVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVA 106

Query: 135 PVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH 194
              S+QAE W+FG IGR DAE+QLL   N  G+FLIRESE+ KG +SLS+ D     G  
Sbjct: 107 EDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-----GAV 161

Query: 195 VKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCT-IMKPQTLGLAK 253
           VKHY+I++LD GG+++T R  F+++ E V HY + +DGLC  L  PC  I  P    L+ 
Sbjct: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221

Query: 254 ---DAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVM 310
              D WEI R+SI L +RLG+G FG+VW G WN +T VAVKTLKPG+M P  FL EAQ+M
Sbjct: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281

Query: 311 KLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEG 369
           K LRH KL+QLYAV + E+PIYI+TE M HGSL ++L+N  G  + L Q VDMAAQVA G
Sbjct: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341

Query: 370 MAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIK---DDEYNPCQGSKFPIKWTA 426
           MAY+E  NYIHRDL A N+LVGE    K+ADFGLAR+ K   +D Y      K P+KWTA
Sbjct: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401

Query: 427 PEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPAS 486
           PEA    +F+IKSDVWSFGILL E+IT G++PY GM   +V++ + Q Y +P P  CP  
Sbjct: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461

Query: 487 LYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
            Y  M + W  +P+ERPTFE L+  LEDYF
Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF 491


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  364 bits (935), Expect = e-101
 Identities = 197/452 (43%), Positives = 278/452 (61%), Gaps = 15/452 (3%)

Query: 71  IRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIP 129
           + G S     LF+ALYD+ A  ++ L+ TKGEK  +L  N  G+W EA++ +    G +P
Sbjct: 55  LAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG--QGWVP 112

Query: 130 SNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQ 189
           SNY+ PV+S++   WY G + R  AE  L S  N  G+FL+RESE++ G  S+S+R    
Sbjct: 113 SNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---- 166

Query: 190 TRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM-KPQT 248
                V HY+I     G  Y+++  +FN++ ELV H+  V DGL   L  P     KP  
Sbjct: 167 -YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTV 225

Query: 249 LGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLKPGTMSPKAFLE 305
            G++   D WE+ R+ IT++ +LG G +G+V+ G W   S  VAVKTLK  TM  + FL+
Sbjct: 226 YGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 285

Query: 306 EAQVMKLLRHDKLVQLYAVVSEEP-IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAA 364
           EA VMK ++H  LVQL  V + EP  YI+TEFM +G+LLD+L+    Q++    L+ MA 
Sbjct: 286 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 345

Query: 365 QVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKW 424
           Q++  M Y+E+ N+IHRDL A N LVGE    K+ADFGL+RL+  D Y    G+KFPIKW
Sbjct: 346 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 405

Query: 425 TAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCP 484
           TAPE+  + +F+IKSDVW+FG+LL E+ T G  PYPG++  +V E +E+ Y M  P GCP
Sbjct: 406 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 465

Query: 485 ASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
             +YE M   W+ +P +RP+F  +    E  F
Sbjct: 466 EKVYELMRACWQWNPSDRPSFAEIHQAFETMF 497


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  364 bits (935), Expect = e-101
 Identities = 197/452 (43%), Positives = 278/452 (61%), Gaps = 15/452 (3%)

Query: 71  IRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIP 129
           + G S     LF+ALYD+ A  ++ L+ TKGEK  +L  N  G+W EA++ +    G +P
Sbjct: 74  LAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG--QGWVP 131

Query: 130 SNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQ 189
           SNY+ PV+S++   WY G + R  AE  L S  N  G+FL+RESE++ G  S+S+R    
Sbjct: 132 SNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR---- 185

Query: 190 TRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM-KPQT 248
                V HY+I     G  Y+++  +FN++ ELV H+  V DGL   L  P     KP  
Sbjct: 186 -YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTV 244

Query: 249 LGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLKPGTMSPKAFLE 305
            G++   D WE+ R+ IT++ +LG G +G+V+ G W   S  VAVKTLK  TM  + FL+
Sbjct: 245 YGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 304

Query: 306 EAQVMKLLRHDKLVQLYAVVSEEP-IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAA 364
           EA VMK ++H  LVQL  V + EP  YI+TEFM +G+LLD+L+    Q++    L+ MA 
Sbjct: 305 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 364

Query: 365 QVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKW 424
           Q++  M Y+E+ N+IHRDL A N LVGE    K+ADFGL+RL+  D Y    G+KFPIKW
Sbjct: 365 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 424

Query: 425 TAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCP 484
           TAPE+  + +F+IKSDVW+FG+LL E+ T G  PYPG++  +V E +E+ Y M  P GCP
Sbjct: 425 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 484

Query: 485 ASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
             +YE M   W+ +P +RP+F  +    E  F
Sbjct: 485 EKVYELMRACWQWNPSDRPSFAEIHQAFETMF 516


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  364 bits (935), Expect = e-101
 Identities = 206/489 (42%), Positives = 288/489 (58%), Gaps = 23/489 (4%)

Query: 36  PDPTKARPASSFAHIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTE 93
           PD T+A       H P   +   QA+N     S    + G +     LF+ALYD+ A  +
Sbjct: 34  PDLTEA------LHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGD 87

Query: 94  DDLTFTKGEKFHILN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRK 152
           + L+ TKGEK  +L  N  G+W E RS +    G +PSNY+ PV+S++   WY G + R 
Sbjct: 88  NTLSITKGEKLRVLGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRS 145

Query: 153 DAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITT 212
            AE  L S  N  G+FL+RESE++ G  S+S+R         V HY+I     G  Y+T 
Sbjct: 146 AAEYLLSSLIN--GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTA 198

Query: 213 RVQFNSVQELVQHYMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRL 269
             +F+++ ELV H+  V DGL   L  P     KP   G++   D WE+ R+ IT++ +L
Sbjct: 199 ESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKL 258

Query: 270 GTGCFGDVWLGTWNG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-E 327
           G G +G+V++G W   S  VAVKTLK  TM  + FL+EA VMK ++H  LVQL  V + E
Sbjct: 259 GGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLE 318

Query: 328 EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAAN 387
            P YIVTE+M +G+LLD+L+    +++    L+ MA Q++  M Y+E+ N+IHRDL A N
Sbjct: 319 PPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARN 378

Query: 388 ILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGIL 447
            LVGE    K+ADFGL+RL+  D Y    G+KFPIKWTAPE+  +  F+IKSDVW+FG+L
Sbjct: 379 CLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVL 438

Query: 448 LTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEY 507
           L E+ T G  PYPG++  +V + +E+GY M  P GCP  +YE M   W+  P +RP+F  
Sbjct: 439 LWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAE 498

Query: 508 LQSFLEDYF 516
                E  F
Sbjct: 499 THQAFETMF 507


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  364 bits (934), Expect = e-100
 Identities = 213/523 (40%), Positives = 300/523 (57%), Gaps = 26/523 (4%)

Query: 11  PVATAKEDAG--LEGDFRSYGAADHY------GPDPTKARPASSFA-HIPNYSNFSSQAI 61
           P    ++ AG   E  F  +   DH+      G +  K   +S  A H P   +   QA+
Sbjct: 30  PSGRRRDPAGRTTETGFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQAL 89

Query: 62  NPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHILN-NTEGDWWEAR 118
           N     S    + G +     LF+ALYD+ A  ++ L+ TKGEK  +L  N  G+W E R
Sbjct: 90  NEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR 149

Query: 119 SLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKG 178
           S +    G +PSNY+ PV+S++   WY G + R  AE  L S  N  G+FL+RESE++ G
Sbjct: 150 SKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPG 205

Query: 179 AYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLI 238
             S+S+R         V HY+I     G  Y+T   +F+++ ELV H+  V DGL   L 
Sbjct: 206 QLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLH 260

Query: 239 APCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTWNG-STKVAVKTLK 294
            P     KP   G++   D WE+ R+ IT++ +LG G +G+V++G W   S  VAVKTLK
Sbjct: 261 YPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLK 320

Query: 295 PGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQD 353
             TM  + FL+EA VMK ++H  LVQL  V + E P YIVTE+M +G+LLD+L+    ++
Sbjct: 321 EDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREE 380

Query: 354 LRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYN 413
           +    L+ MA Q++  M Y+E+ N+IHRDL A N LVGE    K+ADFGL+RL+  D Y 
Sbjct: 381 VTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYT 440

Query: 414 PCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQ 473
              G+KFPIKWTAPE+  +  F+IKSDVW+FG+LL E+ T G  PYPG++  +V + +E+
Sbjct: 441 AHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEK 500

Query: 474 GYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
           GY M  P GCP  +YE M   W+  P +RP+F       E  F
Sbjct: 501 GYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 543


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  363 bits (933), Expect = e-100
 Identities = 202/476 (42%), Positives = 283/476 (59%), Gaps = 17/476 (3%)

Query: 49  HIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHI 106
           H P   +   QA+N     S    + G +     LF+ALYD+ A  ++ L+ TKGEK  +
Sbjct: 62  HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRV 121

Query: 107 LN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQ 165
           L  N  G+W E RS +    G +PSNY+ PV+S++   WY G + R  AE  L S  N  
Sbjct: 122 LGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-- 177

Query: 166 GAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225
           G+FL+RESE++ G  S+S+R         V HY+I     G  Y+T   +F+++ ELV H
Sbjct: 178 GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 232

Query: 226 YMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTW 282
           +  V DGL   L  P     KP   G++   D WE+ R+ IT++ +LG G +G+V++G W
Sbjct: 233 HSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 292

Query: 283 NG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHG 340
              S  VAVKTLK  TM  + FL+EA VMK ++H  LVQL  V + E P YIVTE+M +G
Sbjct: 293 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYG 352

Query: 341 SLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIAD 400
           +LLD+L+    +++    L+ MA Q++  M Y+E+ N+IHRDL A N LVGE    K+AD
Sbjct: 353 NLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 412

Query: 401 FGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYP 460
           FGL+RL+  D Y    G+KFPIKWTAPE+  +  F+IKSDVW+FG+LL E+ T G  PYP
Sbjct: 413 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP 472

Query: 461 GMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
           G++  +V + +E+GY M  P GCP  +YE M   W+  P +RP+F       E  F
Sbjct: 473 GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 528


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  363 bits (933), Expect = e-100
 Identities = 202/476 (42%), Positives = 283/476 (59%), Gaps = 17/476 (3%)

Query: 49  HIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHI 106
           H P   +   QA+N     S    + G +     LF+ALYD+ A  ++ L+ TKGEK  +
Sbjct: 56  HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRV 115

Query: 107 LN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQ 165
           L  N  G+W E RS +    G +PSNY+ PV+S++   WY G + R  AE  L S  N  
Sbjct: 116 LGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-- 171

Query: 166 GAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225
           G+FL+RESE++ G  S+S+R         V HY+I     G  Y+T   +F+++ ELV H
Sbjct: 172 GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 226

Query: 226 YMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTW 282
           +  V DGL   L  P     KP   G++   D WE+ R+ IT++ +LG G +G+V++G W
Sbjct: 227 HSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 286

Query: 283 NG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHG 340
              S  VAVKTLK  TM  + FL+EA VMK ++H  LVQL  V + E P YIVTE+M +G
Sbjct: 287 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYG 346

Query: 341 SLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIAD 400
           +LLD+L+    +++    L+ MA Q++  M Y+E+ N+IHRDL A N LVGE    K+AD
Sbjct: 347 NLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 406

Query: 401 FGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYP 460
           FGL+RL+  D Y    G+KFPIKWTAPE+  +  F+IKSDVW+FG+LL E+ T G  PYP
Sbjct: 407 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP 466

Query: 461 GMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
           G++  +V + +E+GY M  P GCP  +YE M   W+  P +RP+F       E  F
Sbjct: 467 GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 522


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  363 bits (933), Expect = e-100
 Identities = 202/476 (42%), Positives = 283/476 (59%), Gaps = 17/476 (3%)

Query: 49  HIPNYSNFSSQAINPGFLDSG--TIRGVSGIGVTLFIALYDYEARTEDDLTFTKGEKFHI 106
           H P   +   QA+N     S    + G +     LF+ALYD+ A  ++ L+ TKGEK  +
Sbjct: 62  HRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRV 121

Query: 107 LN-NTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAEEWYFGKIGRKDAERQLLSPGNPQ 165
           L  N  G+W E RS +    G +PSNY+ PV+S++   WY G + R  AE  L S  N  
Sbjct: 122 LGYNQNGEWSEVRSKNG--QGWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLIN-- 177

Query: 166 GAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225
           G+FL+RESE++ G  S+S+R         V HY+I     G  Y+T   +F+++ ELV H
Sbjct: 178 GSFLVRESESSPGQLSISLR-----YEGRVYHYRINTTADGKVYVTAESRFSTLAELVHH 232

Query: 226 YMEVNDGLCNLLIAPCT-IMKPQTLGLAK--DAWEISRSSITLERRLGTGCFGDVWLGTW 282
           +  V DGL   L  P     KP   G++   D WE+ R+ IT++ +LG G +G+V++G W
Sbjct: 233 HSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW 292

Query: 283 NG-STKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVS-EEPIYIVTEFMCHG 340
              S  VAVKTLK  TM  + FL+EA VMK ++H  LVQL  V + E P YIVTE+M +G
Sbjct: 293 KKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYG 352

Query: 341 SLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIAD 400
           +LLD+L+    +++    L+ MA Q++  M Y+E+ N+IHRDL A N LVGE    K+AD
Sbjct: 353 NLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVAD 412

Query: 401 FGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYP 460
           FGL+RL+  D Y    G+KFPIKWTAPE+  +  F+IKSDVW+FG+LL E+ T G  PYP
Sbjct: 413 FGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYP 472

Query: 461 GMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYF 516
           G++  +V + +E+GY M  P GCP  +YE M   W+  P +RP+F       E  F
Sbjct: 473 GIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMF 528


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  359 bits (922), Expect = 3e-99
 Identities = 193/435 (44%), Positives = 261/435 (60%), Gaps = 12/435 (2%)

Query: 81  LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV--DS 138
           LF+ALYD+ AR   +L+  +G++   L    G  +  R       G +P  +VA    ++
Sbjct: 55  LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET 114

Query: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHY 198
           +  + WYF  + R  A++ LLSP N  GAFLIR SE++ G YSLS+R   +     V HY
Sbjct: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAK-----VCHY 169

Query: 199 KIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEI 258
           ++     G  Y+     F  ++EL+ +Y      + N L+ PC   K       +D WE 
Sbjct: 170 RVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPR----QDVWER 225

Query: 259 SRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKL 318
             S   L R+LG G FG+VW G W GS  VA+K +K   M      +E Q +K LRH++L
Sbjct: 226 PHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERL 285

Query: 319 VQLYAVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMN 377
           ++L+AV S  EP+YIVTE M  G+L  FL  PEG+ LRLP L+  A QVAEGM+Y+E   
Sbjct: 286 IRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQR 345

Query: 378 YIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTI 437
            +HRDL A N+LV + LACK+ADFGLARL+KDD Y+P   SK P+KWTAPEAA +  F+ 
Sbjct: 346 VVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQ 405

Query: 438 KSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRL 497
           KSDVWSFG+LL E+ T G+ PY GM   E L+Q+ +GY +P P  CPA +Y  M + WR 
Sbjct: 406 KSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRS 465

Query: 498 DPEERPTFEYLQSFL 512
            PEERP+F  L+  L
Sbjct: 466 SPEERPSFATLREKL 480


>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
          Length = 451

 Score =  357 bits (915), Expect = 2e-98
 Identities = 196/446 (43%), Positives = 275/446 (61%), Gaps = 17/446 (3%)

Query: 82  FIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKT---GCIPSNYVAPVDS 138
           ++ L+D+++RT+++L+F  G+ FH+    E  WW      +G     G +P NY+A  ++
Sbjct: 13  YVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERET 72

Query: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHY 198
           +++E W+FG I R +A R+L + GN  GAFLIR SE     Y LS+RD        V+HY
Sbjct: 73  VESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQA-----VRHY 127

Query: 199 KIRKLDMGGYYITTRVQFNSVQELVQHY--MEVNDGLCNLLIAPCTIMKPQTLGLAKDAW 256
           KI +   G  ++   V F S+ ELV ++    ++ GL   L APC   +P+ L    D W
Sbjct: 128 KIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGL--RLAAPCRKHEPEPLPHWDD-W 184

Query: 257 EISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLE-EAQVMKLLRH 315
           E  R   TL R+LG+G FG+V+ G W    +VA+K +    +  +  L+ E Q MK LRH
Sbjct: 185 ERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRH 244

Query: 316 DKLVQLYAVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYME 374
             ++ LYAVVS  +P+YI+TE M  GSLL+ L++ + + L + +L+D+A QVAEGM Y+E
Sbjct: 245 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 304

Query: 375 RMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGR 434
             NYIHRDL A NILVGE   CK+ DFGLARLIK+D Y        P KWTAPEA   G 
Sbjct: 305 SQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLS-HDHNIPYKWTAPEALSRGH 363

Query: 435 FTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQT 494
           ++ KSDVWSFGILL E+ ++G++PYPGM+  E   +V+ GY MPCP  CP S+++ M   
Sbjct: 364 YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTC 423

Query: 495 WRLDPEERPTFEYLQSFLEDYFTSAE 520
           W  DPE+RP F+ L+  L   FTS E
Sbjct: 424 WCRDPEQRPCFKALRERLSS-FTSYE 448


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  320 bits (821), Expect = 2e-87
 Identities = 175/432 (40%), Positives = 255/432 (59%), Gaps = 11/432 (2%)

Query: 84  ALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAP--VDSIQA 141
           ALYD+  R   +L   + E++ IL      WW+AR    G  G IPSNYV    + +++ 
Sbjct: 89  ALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD-RLGNEGLIPSNYVTENKITNLEI 147

Query: 142 EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI-RDWDQTRGDHVKHYKI 200
            EWY   I R  AE  LL   + +GAF++R+S    G+Y++S+     ++    +KHY+I
Sbjct: 148 YEWYHRNITRNQAEH-LLRQESKEGAFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQI 205

Query: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLGLAKDAWE 257
           +K D G +Y+  R  F S+ EL+ ++     GL   L  P  +M    P T G + + WE
Sbjct: 206 KKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWE 265

Query: 258 ISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDK 317
           I  S +   + +G+G FG V LG W    +VA+K +  G+MS + F+EEA+VM  L H K
Sbjct: 266 IDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSK 325

Query: 318 LVQLYAV-VSEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERM 376
           LVQLY V +  +P+YIVTEFM +G LL++L+  +G+ LR   L+ +   + EGM Y+ER 
Sbjct: 326 LVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGK-LRKEMLLSVCQDICEGMEYLERN 384

Query: 377 NYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFT 436
            YIHRDL A N LV      KI+DFG+ R + DDEY    G+KFPIKW+ PE  LF +++
Sbjct: 385 GYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYS 444

Query: 437 IKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWR 496
            KSDVWSFG+L+ E+ T+G++P+   +  +V+E + +G+ +  P   P S+YE M   W 
Sbjct: 445 SKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWH 504

Query: 497 LDPEERPTFEYL 508
             PE RPTF  L
Sbjct: 505 EKPEGRPTFAEL 516


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score =  310 bits (793), Expect = 3e-84
 Identities = 167/440 (37%), Positives = 254/440 (57%), Gaps = 14/440 (3%)

Query: 83  IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV-DSIQA 141
           +ALYDY     +DL   KG+++ IL  +   WW AR   +G+ G IPSNYV    DSI+ 
Sbjct: 220 VALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEM 278

Query: 142 EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH---VKHY 198
            EWY   + R  AE QLL     +G F++R+S    G Y++S+  + ++ GD    ++HY
Sbjct: 279 YEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSV--FAKSTGDPQGVIRHY 334

Query: 199 KIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLGLAKDA 255
            +       YY+  +  F+++ EL+ ++   + GL + L  P +      P T GL   +
Sbjct: 335 VVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGS 394

Query: 256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRH 315
           WEI    +T  + LGTG FG V  G W G   VA+K +K G+MS   F+EEA+VM  L H
Sbjct: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454

Query: 316 DKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYME 374
           +KLVQLY V +++ PI+I+TE+M +G LL++L+    +  +  QL++M   V E M Y+E
Sbjct: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEYLE 513

Query: 375 RMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGR 434
              ++HRDL A N LV ++   K++DFGL+R + DDEY    GSKFP++W+ PE  ++ +
Sbjct: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573

Query: 435 FTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQT 494
           F+ KSD+W+FG+L+ E+ + G++PY      E  E + QG  +  P      +Y  M   
Sbjct: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633

Query: 495 WRLDPEERPTFEYLQSFLED 514
           W    +ERPTF+ L S + D
Sbjct: 634 WHEKADERPTFKILLSNILD 653


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  309 bits (791), Expect = 5e-84
 Identities = 174/443 (39%), Positives = 255/443 (57%), Gaps = 13/443 (2%)

Query: 81  LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDS-- 138
           + +A+YD++A    DL   +G+++ IL   +  WW AR    G  G IPSNYV    S  
Sbjct: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241

Query: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH-VKH 197
           +   EWY   + R  AE QLL   + +G F++R+S +  G Y++S+       G    +H
Sbjct: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299

Query: 198 YKIRKLDMGG--YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM---KPQTLGLA 252
           Y I++       YY+  +  F S+ E+++++     GL   L  P ++     P T G +
Sbjct: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359

Query: 253 KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKL 312
            + WEI+ S +T  R LG+G FG V LG W    KVA+K ++ G M  + F+EEA+VM  
Sbjct: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419

Query: 313 LRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371
           L H KLVQLY V +++ PIYIVTEFM  G LL+FL+  +G   R   L+ M   V EGM 
Sbjct: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478

Query: 372 YMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAAL 431
           Y+ER ++IHRDL A N LV E    K++DFG+AR + DD+Y    G+KFP+KW  PE   
Sbjct: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538

Query: 432 FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAM 491
           + RF+ KSDVWSFG+L+ E+ T+GR+P+      EV+  V +G+ +  P      +YE M
Sbjct: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598

Query: 492 EQTWRLDPEERPTFEYLQSFLED 514
            + W+  PE RP+FE L   +++
Sbjct: 599 LRCWQEKPEGRPSFEDLLRTIDE 621


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  305 bits (780), Expect = 9e-83
 Identities = 168/439 (38%), Positives = 249/439 (56%), Gaps = 14/439 (3%)

Query: 80  TLFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV--D 137
           T+ IALYDY+     +L   + E++ +L+++E  WW  +   +G  G +PS+Y+     +
Sbjct: 174 TVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLVEKSPN 232

Query: 138 SIQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSI--RDWDQTRGDHV 195
           +++  EWY   I R  AE+ LL  G  +GAF++R+S T  G Y++S+  +         +
Sbjct: 233 NLETYEWYNKSISRDKAEKLLLDTGK-EGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCI 290

Query: 196 KHYKIRKLDMGG--YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLG 250
           KHY I++ +     YY+  +  F+S+  L+ ++     GL   L  P    +   P T G
Sbjct: 291 KHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG 350

Query: 251 LAKDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVM 310
           L    W I  S +T  + +G+G FG V LG W    KVA+KT++ G MS + F+EEA+VM
Sbjct: 351 LRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVM 410

Query: 311 KLLRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEG 369
             L H KLVQLY V  E+ PI +V EFM HG L D+L+   G       L+ M   V EG
Sbjct: 411 MKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL-FAAETLLGMCLDVCEG 469

Query: 370 MAYMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEA 429
           MAY+E    IHRDL A N LVGE    K++DFG+ R + DD+Y    G+KFP+KW +PE 
Sbjct: 470 MAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEV 529

Query: 430 ALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYE 489
             F R++ KSDVWSFG+L+ E+ ++G+IPY   +  EV+E +  G+ +  P      +Y+
Sbjct: 530 FSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQ 589

Query: 490 AMEQTWRLDPEERPTFEYL 508
            M   W+  PE+RP F  L
Sbjct: 590 IMNHCWKERPEDRPAFSRL 608


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  285 bits (730), Expect = 6e-77
 Identities = 174/442 (39%), Positives = 243/442 (54%), Gaps = 26/442 (5%)

Query: 83  IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
           IA Y++    E DL F KG+   I+  T+   W       G+ G IP+NYV   + ++A 
Sbjct: 15  IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74

Query: 143 E------WYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVK 196
                  W+ GKI R+ AER L  P    G FL+RES    G Y+L +     +    V+
Sbjct: 75  TKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCV-----SCDGKVE 127

Query: 197 HYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLG---LAK 253
           HY+I         I   V F ++ +LV+HY    DGLC  LI P  +M+          +
Sbjct: 128 HYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP-KVMEGTVAAQDEFYR 185

Query: 254 DAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLL 313
             W ++   + L + +G G FGDV LG + G+ KVAVK +K    + +AFL EA VM  L
Sbjct: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMTQL 243

Query: 314 RHDKLVQLYAVVSEEP--IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371
           RH  LVQL  V+ EE   +YIVTE+M  GSL+D+L++     L    L+  +  V E M 
Sbjct: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303

Query: 372 YMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAAL 431
           Y+E  N++HRDL A N+LV E    K++DFGL +     +       K P+KWTAPEA  
Sbjct: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAPEALR 359

Query: 432 FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAM 491
             +F+ KSDVWSFGILL E+ + GR+PYP +  ++V+ +VE+GY M  P GCP ++YE M
Sbjct: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419

Query: 492 EQTWRLDPEERPTFEYLQSFLE 513
           +  W LD   RP+F  L+  LE
Sbjct: 420 KNCWHLDAAMRPSFLQLREQLE 441


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.422 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,368,704
Number of Sequences: 37866
Number of extensions: 984508
Number of successful extensions: 4606
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 775
Number of HSP's successfully gapped in prelim test: 302
Number of HSP's that attempted gapping in prelim test: 2224
Number of HSP's gapped (non-prelim): 1370
length of query: 529
length of database: 18,247,518
effective HSP length: 107
effective length of query: 422
effective length of database: 14,195,856
effective search space: 5990651232
effective search space used: 5990651232
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.