Search of human proteins with 48475052

Search of human proteins with 48475052

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|48475052 secreted frizzled-related protein 2 precursor [Homo
sapiens]
         (295 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|48475052 secreted frizzled-related protein 2 precursor [Homo ...   618   e-177
gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]       238   6e-63
gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]        233   2e-61
gi|13994190 frizzled 8 [Homo sapiens]                                 107   1e-23
gi|4503835 frizzled 9 [Homo sapiens]                                  107   2e-23
gi|22547161 frizzled 4 [Homo sapiens]                                 106   2e-23
gi|27894385 frizzled 5 precursor [Homo sapiens]                       105   6e-23
gi|4503825 frizzled 1 [Homo sapiens]                                  104   8e-23
gi|6005762 frizzled 10 [Homo sapiens]                                 104   1e-22
gi|4503833 frizzled 7 [Homo sapiens]                                  103   2e-22
gi|4503827 frizzled 2 [Homo sapiens]                                  101   9e-22
gi|38455388 frizzled-related protein [Homo sapiens]                    91   2e-18
gi|29244926 corin [Homo sapiens]                                       88   1e-17
gi|8393378 frizzled 3 [Homo sapiens]                                   87   2e-17
gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]       81   1e-15
gi|34734079 frizzled 6 [Homo sapiens]                                  80   3e-15
gi|13899255 membrane frizzled-related protein [Homo sapiens]           69   5e-12
gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]      61   1e-09
gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]                61   1e-09
gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho...    58   9e-09
gi|50658087 abhydrolase domain containing 4 [Homo sapiens]             33   0.39 
gi|148886718 zinc finger, CCHC domain containing 4 [Homo sapiens]      32   0.87 
gi|23111038 sorting nexin 2 [Homo sapiens]                             30   1.9  
gi|148613884 netrin 1 [Homo sapiens]                                   30   1.9  
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]                30   1.9  
gi|28212222 WFIKKN2 protein [Homo sapiens]                             30   1.9  
gi|4505489 ornithine decarboxylase 1 [Homo sapiens]                    30   2.5  
gi|133778961 testis expressed 15 [Homo sapiens]                        30   2.5  
gi|71274180 PLAC8-like 1 [Homo sapiens]                                29   4.3  
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof...    29   5.6  

>gi|48475052 secreted frizzled-related protein 2 precursor [Homo
           sapiens]
          Length = 295

 Score =  618 bits (1594), Expect = e-177
 Identities = 295/295 (100%), Positives = 295/295 (100%)

Query: 1   MLQGPGSLLLLFLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRL 60
           MLQGPGSLLLLFLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRL
Sbjct: 1   MLQGPGSLLLLFLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRL 60

Query: 61  PNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQ 120
           PNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQ
Sbjct: 61  PNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQ 120

Query: 121 VKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPLASSDHLLPATEEAPKVCEACKNKND 180
           VKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPLASSDHLLPATEEAPKVCEACKNKND
Sbjct: 121 VKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPLASSDHLLPATEEAPKVCEACKNKND 180

Query: 181 DDNDIMETLCKNDFALKIKVKEITYINRDTKIILETKSKTIYKLNGVSERDLKKSVLWLK 240
           DDNDIMETLCKNDFALKIKVKEITYINRDTKIILETKSKTIYKLNGVSERDLKKSVLWLK
Sbjct: 181 DDNDIMETLCKNDFALKIKVKEITYINRDTKIILETKSKTIYKLNGVSERDLKKSVLWLK 240

Query: 241 DSLQCTCEEMNDINAPYLVMGQKQGGELVITSVKRWQKGQREFKRISRSIRKLQC 295
           DSLQCTCEEMNDINAPYLVMGQKQGGELVITSVKRWQKGQREFKRISRSIRKLQC
Sbjct: 241 DSLQCTCEEMNDINAPYLVMGQKQGGELVITSVKRWQKGQREFKRISRSIRKLQC 295


>gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]
          Length = 317

 Score =  238 bits (606), Expect = 6e-63
 Identities = 113/249 (45%), Positives = 159/249 (63%), Gaps = 5/249 (2%)

Query: 36  KRSNCKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFL 95
           K   C  IPA+L LCH + Y+ MRLPNLL HE++ EV +QA +W+PL+ K+CH DT+ FL
Sbjct: 49  KPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL 108

Query: 96  CSLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPL 155
           CSLFAPVC   LD  I PC SLC  V+  CAP+M A+GFPWP+ML C +FP DNDLCI +
Sbjct: 109 CSLFAPVC---LDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAV 165

Query: 156 ASSDHLLPATEEAPKVCEACKNKNDDDNDIMETLCKNDFALKIKVKEITYINRDTKIILE 215
               HL        K+C  C+ ++  D  +ME +C +DF +K+++KEI   N D K+I  
Sbjct: 166 -QFGHLPATAPPVTKICAQCEMEHSADG-LMEQMCSSDFVVKMRIKEIKIENGDRKLIGA 223

Query: 216 TKSKTIYKLNGVSERDLKKSVLWLKDSLQCTCEEMNDINAPYLVMGQKQGGELVITSVKR 275
            K K + K   +  +D K+ VL +K+   C C +++ +   +LVMG+K  G+L++ +V R
Sbjct: 224 QKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYR 283

Query: 276 WQKGQREFK 284
           W K  +E K
Sbjct: 284 WDKKNKEMK 292


>gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]
          Length = 314

 Score =  233 bits (593), Expect = 2e-61
 Identities = 112/263 (42%), Positives = 166/263 (63%), Gaps = 7/263 (2%)

Query: 33  FSYKRSNCKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTK 92
           F  K   C  IPA+L+LCH + Y+ M LPNLL HETM EV +QA +W+PL+ K CH  T+
Sbjct: 51  FYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQ 110

Query: 93  KFLCSLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDNDLC 152
            FLCSLFAPVC   LD  I PC  LC  V+D C PVM  FGF WP+ML+CD+FP + D+C
Sbjct: 111 VFLCSLFAPVC---LDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFP-EGDVC 166

Query: 153 IPLASSDHLLPATEEAPKVCEACKNKNDDDNDIMETLCKNDFALKIKVKEITYINRDTKI 212
           I +   +    +  +   VC  C N+   +  I+E LC ++FAL++K+KE+   N D KI
Sbjct: 167 IAMTPPNATEASKPQGTTVCPPCDNELKSE-AIIEHLCASEFALRMKIKEVKKENGDKKI 225

Query: 213 ILETKSKTIYKLNGVSERDLKKSVLWLKDSLQCTCEEMNDINAPYLVMGQKQGGELVITS 272
           +   K K   KL  + ++DLKK VL+LK+   C C ++++++  +L+MG+K   + ++T+
Sbjct: 226 V--PKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTA 283

Query: 273 VKRWQKGQREFKRISRSIRKLQC 295
           + +W K  +EFK   + ++  +C
Sbjct: 284 IHKWDKKNKEFKNFMKKMKNHEC 306


>gi|13994190 frizzled 8 [Homo sapiens]
          Length = 694

 Score =  107 bits (268), Expect = 1e-23
 Identities = 54/140 (38%), Positives = 76/140 (54%), Gaps = 6/140 (4%)

Query: 34  SYKRSNCKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKK 93
           S K   C+ I   + LC GI Y    +PN   H+T  E   +   + PLV  QC PD K 
Sbjct: 29  SAKELACQEI--TVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKF 86

Query: 94  FLCSLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDND--- 150
           FLCS++ P+CL+D  + + PC S+C + K  CAP+M  +GF WPD + CDR P+  +   
Sbjct: 87  FLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDT 146

Query: 151 LCIPLASSDHLLPATEEAPK 170
           LC+    +D L  A    P+
Sbjct: 147 LCMDYNRTD-LTTAAPSPPR 165


>gi|4503835 frizzled 9 [Homo sapiens]
          Length = 591

 Score =  107 bits (266), Expect = 2e-23
 Identities = 46/104 (44%), Positives = 60/104 (57%)

Query: 47  LQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDD 106
           + +C GI Y   R+PNLLGH +  E   +   + PLV   CH   + FLCSL+AP+C D 
Sbjct: 44  IPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQ 103

Query: 107 LDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDND 150
           +   I  C  +C Q + RCAP+M  F F WPD L+C R P  ND
Sbjct: 104 VSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRND 147


>gi|22547161 frizzled 4 [Homo sapiens]
          Length = 537

 Score =  106 bits (265), Expect = 2e-23
 Identities = 58/169 (34%), Positives = 84/169 (49%), Gaps = 13/169 (7%)

Query: 4   GPGSLLLLFLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNL 63
           G G  L L L     LG ARG   FG  +       C PI   + +C  + Y   ++PNL
Sbjct: 16  GVGLSLGLLLQLLLLLGPARG---FGDEE----ERRCDPI--RISMCQNLGYNVTKMPNL 66

Query: 64  LGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKD 123
           +GHE   +   Q   + PL+   C    + FLCS++ P+C + ++  I PC  +C+ VK 
Sbjct: 67  VGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKR 126

Query: 124 RCAPVMSAFGFPWPDMLECDRFPQDND---LCIPLASSDHLLPATEEAP 169
           RC PV+  FGF WP+ L C +FP  ND   +C+     D  +P   + P
Sbjct: 127 RCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCME-GPGDEEVPLPHKTP 174


>gi|27894385 frizzled 5 precursor [Homo sapiens]
          Length = 585

 Score =  105 bits (261), Expect = 6e-23
 Identities = 53/142 (37%), Positives = 75/142 (52%), Gaps = 13/142 (9%)

Query: 5   PGSLLLLFLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLL 64
           P SLLLL LA            L G+   + K   C+ I   + +C GI Y    +PN  
Sbjct: 9   PPSLLLLLLAQ-----------LVGRAAAASKAPVCQEI--TVPMCRGIGYNLTHMPNQF 55

Query: 65  GHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKDR 124
            H+T  E   +   + PLV  QC PD + FLCS++ P+CL D  + + PC S+C + K  
Sbjct: 56  NHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAG 115

Query: 125 CAPVMSAFGFPWPDMLECDRFP 146
           C+P+M  +GF WP+ + CDR P
Sbjct: 116 CSPLMRQYGFAWPERMSCDRLP 137


>gi|4503825 frizzled 1 [Homo sapiens]
          Length = 647

 Score =  104 bits (260), Expect = 8e-23
 Identities = 54/142 (38%), Positives = 79/142 (55%), Gaps = 9/142 (6%)

Query: 31  PDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPD 90
           PD  Y    C+PI  ++ LC  I Y    +PNLLGH   ++   +   + PLV  QC  +
Sbjct: 111 PDHGY----CQPI--SIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSAE 164

Query: 91  TKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQD-- 148
            K FLCS++APVC   L++ + PC SLC + +  C  +M+ FGF WPD L+C++FP    
Sbjct: 165 LKFFLCSMYAPVC-TVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPVHGA 223

Query: 149 NDLCIPLASSDHLLPATEEAPK 170
            +LC+   +SD   P     P+
Sbjct: 224 GELCVGQNTSDKGTPTPSLLPE 245


>gi|6005762 frizzled 10 [Homo sapiens]
          Length = 581

 Score =  104 bits (259), Expect = 1e-22
 Identities = 45/111 (40%), Positives = 64/111 (57%), Gaps = 2/111 (1%)

Query: 40  CKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLF 99
           C+PI   + +C  I Y   R+PNL+GHE  +E   Q   + PLV   CH   + FLCSL+
Sbjct: 34  CQPI--EIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLY 91

Query: 100 APVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDND 150
           AP+C + +   I  C  +C Q + +C+P+M  F F WPD L+C + P  ND
Sbjct: 92  APMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKND 142


>gi|4503833 frizzled 7 [Homo sapiens]
          Length = 574

 Score =  103 bits (256), Expect = 2e-22
 Identities = 50/122 (40%), Positives = 72/122 (59%), Gaps = 5/122 (4%)

Query: 40  CKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLF 99
           C+PI  ++ LC  I Y    LPNLLGH   ++   +   + PLV  QC P+ + FLCS++
Sbjct: 49  CQPI--SIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMY 106

Query: 100 APVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQD--NDLCIPLAS 157
           APVC   LD+ I PC SLC + +  C  +M+ FGF WP+ L C+ FP     ++C+   +
Sbjct: 107 APVC-TVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNT 165

Query: 158 SD 159
           SD
Sbjct: 166 SD 167


>gi|4503827 frizzled 2 [Homo sapiens]
          Length = 565

 Score =  101 bits (251), Expect = 9e-22
 Identities = 56/159 (35%), Positives = 85/159 (53%), Gaps = 12/159 (7%)

Query: 8   LLLLFLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLLGHE 67
           LLLL  A        +G+ +   PD  +    C+PI  ++ LC  I Y    +PNLLGH 
Sbjct: 14  LLLLPAAGPAQFHGEKGISI---PDHGF----CQPI--SIPLCTDIAYNQTIMPNLLGHT 64

Query: 68  TMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKDRCAP 127
             ++   +   + PLV  QC P+ + FLCS++APVC   L++ I PC S+C + +  C  
Sbjct: 65  NQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVC-TVLEQAIPPCRSICERARQGCEA 123

Query: 128 VMSAFGFPWPDMLECDRFPQD--NDLCIPLASSDHLLPA 164
           +M+ FGF WP+ L C+ FP+     +C+    S+   PA
Sbjct: 124 LMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPA 162


>gi|38455388 frizzled-related protein [Homo sapiens]
          Length = 325

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 73/269 (27%), Positives = 124/269 (46%), Gaps = 28/269 (10%)

Query: 5   PGSLLLLFLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLL 64
           PG +LLL       L +   L L   P    + + C+P+   + LC  + +   ++PN L
Sbjct: 6   PGGMLLL----RAGLLALAALCLLRVP--GARAAACEPV--RIPLCKSLPWNMTKMPNHL 57

Query: 65  GHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVC-LDDLDETIQPCHSLCVQVKD 123
            H T    +     +  L+   C PD   FLC+++AP+C +D   E I+PC S+C + + 
Sbjct: 58  HHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAPICTIDFQHEPIKPCKSVCERARQ 117

Query: 124 RCAPVMSAFGFPWPDMLECDRFP-QDNDLCI---PLASSDHLLPATEEAPKVC-----EA 174
            C P++  +   WP+ L C+  P  D  +CI    + ++D      + +   C     E 
Sbjct: 118 GCEPILIKYRHSWPENLACEELPVYDRGVCISPEAIVTADGADFPMDSSNGNCRGASSER 177

Query: 175 CKNKNDDDNDIMETLCKN--DFALKIKVKEITYINRDTKIILETKSKTIYKLNGVSERDL 232
           CK K        +T  +N  ++ ++ KVKEI     D   ++E K   I K + V   ++
Sbjct: 178 CKCK--PIRATQKTYFRNNYNYVIRAKVKEIKTKCHDVTAVVEVKE--ILKSSLV---NI 230

Query: 233 KKSVLWLKDSLQCTCEEMNDINAPYLVMG 261
            +  + L  S  C C  +N +N  Y++MG
Sbjct: 231 PRDTVNLYTSSGCLCPPLN-VNEEYIIMG 258


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 53/184 (28%), Positives = 79/184 (42%), Gaps = 13/184 (7%)

Query: 18  CLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLLGHETMKE--VLEQ 75
           CL S  G  L    +     S C+PI   L+LC  + Y +   PN  GH T KE  +  +
Sbjct: 433 CLDSCGGSSLCDPNNSLNNCSQCEPI--TLELCMNLPYNSTSYPNYFGHRTQKEASISWE 490

Query: 76  AGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFP 135
           +  +  LV   C+     F C++  P C  +  E I PC +LC   K+RC  V+   G  
Sbjct: 491 SSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQ 550

Query: 136 WPDMLECDRFPQDN---------DLCIPLASSDHLLPATEEAPKVCEACKNKNDDDNDIM 186
           WP+  +C +FP++N         D  +   S  H    + +       C  + D D+D  
Sbjct: 551 WPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSD 610

Query: 187 ETLC 190
           E  C
Sbjct: 611 EENC 614



 Score = 49.3 bits (116), Expect = 4e-06
 Identities = 21/61 (34%), Positives = 31/61 (50%), Gaps = 2/61 (3%)

Query: 87  CHPDTKKFLCSLFAPVCLDDLDET--IQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDR 144
           C+     F C+L  P C+ D D++  + PC S C   K+ C  V+    + WPD L C +
Sbjct: 183 CYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQ 242

Query: 145 F 145
           F
Sbjct: 243 F 243


>gi|8393378 frizzled 3 [Homo sapiens]
          Length = 666

 Score = 86.7 bits (213), Expect = 2e-17
 Identities = 44/131 (33%), Positives = 68/131 (51%), Gaps = 3/131 (2%)

Query: 39  NCKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSL 98
           +C+PI   L++C  + Y    +PNLL H   +        + P+V   C  D + FLC+L
Sbjct: 27  SCEPI--TLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCAL 84

Query: 99  FAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPLASS 158
           +AP+C++    T+ PC  LC +    C+ +M  FG PWP+ +EC RFP  ++    L   
Sbjct: 85  YAPICMEYGRVTL-PCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFPDCDEPYPRLVDL 143

Query: 159 DHLLPATEEAP 169
           +     TE AP
Sbjct: 144 NLAGEPTEGAP 154


>gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]
          Length = 346

 Score = 80.9 bits (198), Expect = 1e-15
 Identities = 48/183 (26%), Positives = 86/183 (46%), Gaps = 9/183 (4%)

Query: 47  LQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVC-LD 105
           + +C  + +   R+PN L H T +  +     +  LV   C    + FLC+++AP+C L+
Sbjct: 29  IPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAPICTLE 88

Query: 106 DLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFP-QDNDLCIPLASSDHLLPA 164
            L + I+PC S+C + +D C P+M  +   WP+ L CD  P  D  +CI   +    LP 
Sbjct: 89  FLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPE 148

Query: 165 ----TEEAPKVCEACKNKNDDDNDIMETLCKNDFALKIKVKEITYINRDTKIILETKSKT 220
                +  P +    +  + D   +    CK     K+K    TY++++   ++  K K 
Sbjct: 149 DVKWIDITPDMMVQERPLDVDCKRLSPDRCK---CKKVKPTLATYLSKNYSYVIHAKIKA 205

Query: 221 IYK 223
           + +
Sbjct: 206 VQR 208


>gi|34734079 frizzled 6 [Homo sapiens]
          Length = 706

 Score = 79.7 bits (195), Expect = 3e-15
 Identities = 39/121 (32%), Positives = 59/121 (48%), Gaps = 4/121 (3%)

Query: 40  CKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLF 99
           C+PI   +  C  + Y     PNL+GH        +   ++PL   +C P+ + FLC  F
Sbjct: 24  CEPI--TVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAF 81

Query: 100 APVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPLASSD 159
            P C++ +   + PC  LC +V   C  ++  FG  WP+ LECDR  Q  D  +P+    
Sbjct: 82  VPTCIEQI-HVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRL-QYCDETVPVTFDP 139

Query: 160 H 160
           H
Sbjct: 140 H 140


>gi|13899255 membrane frizzled-related protein [Homo sapiens]
          Length = 579

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 37/126 (29%), Positives = 62/126 (49%), Gaps = 11/126 (8%)

Query: 27  LFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNL-LGHETMKEVLEQAGAWIPLVMK 85
           LF  P+ +     C+P+   +++C G+ Y     PN+ +G  T +EV+E    +  L   
Sbjct: 458 LFPPPELA-----CEPV--QVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSL 510

Query: 86  QCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRF 145
            C+   ++ LC L  P C   L   + PC S+C + + +C   ++  G PWP    C+R 
Sbjct: 511 PCYQHFRRLLCGLLVPRCTP-LGSVLPPCRSVCQEAEHQCQSGLALLGTPWP--FNCNRL 567

Query: 146 PQDNDL 151
           P+  DL
Sbjct: 568 PEAADL 573


>gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]
          Length = 641

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 40/135 (29%), Positives = 63/135 (46%), Gaps = 11/135 (8%)

Query: 43  IPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWI------PLVMKQCHPDTKKFLC 96
           +   L+ C    Y +   PNLL H +  EV+E +  +I       L+  QC+PD +   C
Sbjct: 33  VDLQLRTCSDAAYNHTTFPNLLQHRSW-EVVEASSEYILLSVLHQLLEGQCNPDLRLLGC 91

Query: 97  SLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDR-FPQDNDLCI-P 154
           ++ AP C  +     +PC  +C  +++ C P   A    WP  L+C R F ++++ C  P
Sbjct: 92  AVLAPRC--EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDP 149

Query: 155 LASSDHLLPATEEAP 169
           L      L A E  P
Sbjct: 150 LEKLRGGLEADEALP 164


>gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]
          Length = 652

 Score = 60.8 bits (146), Expect = 1e-09
 Identities = 40/135 (29%), Positives = 63/135 (46%), Gaps = 11/135 (8%)

Query: 43  IPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWI------PLVMKQCHPDTKKFLC 96
           +   L+ C    Y +   PNLL H +  EV+E +  +I       L+  QC+PD +   C
Sbjct: 44  VDLQLRTCSDAAYNHTTFPNLLQHRSW-EVVEASSEYILLSVLHQLLEGQCNPDLRLLGC 102

Query: 97  SLFAPVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDR-FPQDNDLCI-P 154
           ++ AP C  +     +PC  +C  +++ C P   A    WP  L+C R F ++++ C  P
Sbjct: 103 AVLAPRC--EGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDP 160

Query: 155 LASSDHLLPATEEAP 169
           L      L A E  P
Sbjct: 161 LEKLRGGLEADEALP 175


>gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo
           sapiens]
          Length = 1751

 Score = 58.2 bits (139), Expect = 9e-09
 Identities = 34/115 (29%), Positives = 49/115 (42%), Gaps = 5/115 (4%)

Query: 40  CKPIPANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLF 99
           C P+P +L +C  +      LPN L HE+ ++V   A AW  L+   CHP    F C L 
Sbjct: 334 CLPLPPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCLLL 393

Query: 100 APVCLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFP-QDNDLCI 153
            P C         PC   C  ++D C   +     P    + C   P Q++  C+
Sbjct: 394 VPPCGSVPPPAPPPCCQFCEALQDACWSRLGGGRLP----VACASLPTQEDGYCV 444


>gi|50658087 abhydrolase domain containing 4 [Homo sapiens]
          Length = 342

 Score = 32.7 bits (73), Expect = 0.39
 Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 3/80 (3%)

Query: 62  NLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQV 121
           ++LG      VL  AG W P ++++  PD K+     F     D + E I  C++     
Sbjct: 196 SVLGRSNPLAVLRVAGPWGPGLVQRFRPDFKRKFADFFED---DTISEYIYHCNAQNPSG 252

Query: 122 KDRCAPVMSAFGFPWPDMLE 141
           +     +M +FG+    MLE
Sbjct: 253 ETAFKAMMESFGWARRPMLE 272


>gi|148886718 zinc finger, CCHC domain containing 4 [Homo sapiens]
          Length = 513

 Score = 31.6 bits (70), Expect = 0.87
 Identities = 18/55 (32%), Positives = 25/55 (45%), Gaps = 2/55 (3%)

Query: 16  HCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLLGHETMK 70
           H C G   G F+ G+ D  +KRS C  I  + +    +  Q  R  N +  ET K
Sbjct: 436 HSCEGPKHGCFICGELD--HKRSTCPNIATSKRANKAVRKQKQRKSNKMKMETTK 488


>gi|23111038 sorting nexin 2 [Homo sapiens]
          Length = 519

 Score = 30.4 bits (67), Expect = 1.9
 Identities = 20/84 (23%), Positives = 40/84 (47%), Gaps = 6/84 (7%)

Query: 213 ILETKSKTIYKLNGVSERDLKKSVLWLKDSLQCTCEEMNDINAPYLVMGQKQGGELVITS 272
           +L    + I  + GV +  +K    W  +  Q T  +  +  A  +V  +    +     
Sbjct: 392 LLSDYIRLIAAVKGVFDHRMKCWQKW--EDAQITLLKKREAEAKMMVANKPDKIQQAKNE 449

Query: 273 VKRW----QKGQREFKRISRSIRK 292
           ++ W    Q+G+R+F++IS++IRK
Sbjct: 450 IREWEAKVQQGERDFEQISKTIRK 473


>gi|148613884 netrin 1 [Homo sapiens]
          Length = 604

 Score = 30.4 bits (67), Expect = 1.9
 Identities = 34/146 (23%), Positives = 60/146 (41%), Gaps = 18/146 (12%)

Query: 153 IPLASSDHLLPATEEAPKVCEA-CKNKNDDDNDIMETLCKNDFALKIKVKEITYINRDTK 211
           IP+A       + EE P+ C++ CK         M+  CK D+A++I + +        K
Sbjct: 454 IPVAPPTTAASSVEE-PEDCDSYCKASKGKLKINMKKYCKKDYAVQIHILKADKAGDWWK 512

Query: 212 IILETKSKTIYKLNGVSERDLKKSVLWLKD-SLQCTCEEMNDINAPYLVMGQKQG----- 265
             +   S  +YK  G S        LW++   + C C ++  +   YL++G  +      
Sbjct: 513 FTVNIIS--VYK-QGTSRIRRGDQSLWIRSRDIACKCPKIKPLK-KYLLLGNAEDSPDQS 568

Query: 266 ------GELVITSVKRWQKGQREFKR 285
                   LVI     W +  R+F++
Sbjct: 569 GIVADKSSLVIQWRDTWARRLRKFQQ 594


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score = 30.4 bits (67), Expect = 1.9
 Identities = 37/144 (25%), Positives = 64/144 (44%), Gaps = 20/144 (13%)

Query: 158  SDHLLPATEEAPKVC----EACKNKNDDDNDIMETLCKNDFA---LKIKVKEITYINRDT 210
            SDHL    E++ +      +A K  ND    + E L K++     LK KV+E+T  N +T
Sbjct: 1527 SDHLKEQFEKSHEQLLQNIKAEKENNDKIQRLNEELEKSNECAEMLKQKVEELTRQNNET 1586

Query: 211  KIILETKSKTIYKLNGVSERDLKKSVLWLKDSLQCTCEEMNDINAPYLVMGQKQGGELVI 270
            K++++       ++   SE     +++  K ++Q  CE +  I A       +   E + 
Sbjct: 1587 KLMMQ-------RIQAESE-----NIVLEKQTIQQRCEALK-IQADGFKDQLRSTNEHLH 1633

Query: 271  TSVKRWQKGQREFKRISRSIRKLQ 294
               K  Q  QR+ K +   + K Q
Sbjct: 1634 KQTKTEQDFQRKIKCLEEDLAKSQ 1657


>gi|28212222 WFIKKN2 protein [Homo sapiens]
          Length = 576

 Score = 30.4 bits (67), Expect = 1.9
 Identities = 23/99 (23%), Positives = 45/99 (45%), Gaps = 11/99 (11%)

Query: 172 CEACKNKNDDDNDIMETLCKNDFALKIKVKEITYINRDTKIILETKSKTIYK----LNGV 227
           C ACK +      ++ + C++DF +  +V E+T    D+   L T  + +      L  +
Sbjct: 445 CRACKPRQK----LVTSFCRSDFVILGRVSELTE-EPDSGRALVTVDEVLKDEKMGLKFL 499

Query: 228 SERDLKKSVLWLKDSLQCTCEEMNDINAPYLVMGQKQGG 266
            +  L+ ++L +     C C  +     P ++MG+  GG
Sbjct: 500 GQEPLEVTLLHV--DWACPCPNVTVSEMPLIIMGEVDGG 536


>gi|4505489 ornithine decarboxylase 1 [Homo sapiens]
          Length = 461

 Score = 30.0 bits (66), Expect = 2.5
 Identities = 13/34 (38%), Positives = 20/34 (58%), Gaps = 1/34 (2%)

Query: 81  PLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPC 114
           PL+ K+  PD K +  S++ P C D LD  ++ C
Sbjct: 338 PLLQKRPKPDEKYYSSSIWGPTC-DGLDRIVERC 370


>gi|133778961 testis expressed 15 [Homo sapiens]
          Length = 2789

 Score = 30.0 bits (66), Expect = 2.5
 Identities = 12/46 (26%), Positives = 26/46 (56%), Gaps = 3/46 (6%)

Query: 164  ATEEAPKVCEACKNKNDDDNDIMETLCKNDFALKIKVKEITYINRD 209
            ++++ P   + C++  +   D   + CK    LK+ +K++T INR+
Sbjct: 2308 SSKKRPSTVDKCEDSQEQQQDTTVSSCKK---LKVDMKDVTKINRE 2350


>gi|71274180 PLAC8-like 1 [Homo sapiens]
          Length = 177

 Score = 29.3 bits (64), Expect = 4.3
 Identities = 12/41 (29%), Positives = 20/41 (48%), Gaps = 1/41 (2%)

Query: 65  GHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLD 105
           G  T+  +++  G W   +   C  D +   C LF P+CL+
Sbjct: 58  GRTTITAIVQTGGGWSTGLFSVCR-DRRICFCGLFCPMCLE 97


>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
            [Homo sapiens]
          Length = 6907

 Score = 28.9 bits (63), Expect = 5.6
 Identities = 34/130 (26%), Positives = 58/130 (44%), Gaps = 4/130 (3%)

Query: 161  LLPATEEAPKVCEACKNKNDDDNDIMETLCKND--FALKIKVKEITYINRDTKIILETKS 218
            ++PA  E+ +V E  K   D D  I   + K+   +A++ K++EI     + + +L+ KS
Sbjct: 3652 IVPAEIES-QVEECRKALEDIDEKISNEVLKSSPSYAMRRKIEEINNGLHNVEKMLQQKS 3710

Query: 219  KTIYKLNGVSERDLKKSVLWLKDSLQCTCEEMNDINAPYLVMGQKQGGELVITSVKRWQK 278
            K I K   + ++   +  LW    L     E+ DI        Q+    L+I   +  Q 
Sbjct: 3711 KNIEKAQEIQKKMWDELDLW-HSKLNELDSEVQDIVEQDPGQAQEWMDNLMIPFQQYQQV 3769

Query: 279  GQREFKRISR 288
             QR   R S+
Sbjct: 3770 SQRAECRTSQ 3779


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,002,819
Number of Sequences: 37866
Number of extensions: 562343
Number of successful extensions: 1460
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 1415
Number of HSP's gapped (non-prelim): 41
length of query: 295
length of database: 18,247,518
effective HSP length: 102
effective length of query: 193
effective length of database: 14,385,186
effective search space: 2776340898
effective search space used: 2776340898
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.