Guide to the Human Genome
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Search of human proteins with 13375997

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13375997 dehydrogenase/reductase (SDR family) member 12
isoform 2 [Homo sapiens]
         (242 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13375997 dehydrogenase/reductase (SDR family) member 12 isofo...   495   e-140
gi|72534732 dehydrogenase/reductase (SDR family) member 12 isofo...   382   e-106
gi|166795268 retinol dehydrogenase 11 [Homo sapiens]                   85   6e-17
gi|186928839 retinol dehydrogenase 12 [Homo sapiens]                   82   4e-16
gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo...    78   8e-15
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]         74   9e-14
gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens]          74   9e-14
gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo...    70   1e-12
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s...    47   1e-05
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         45   6e-05
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    45   7e-05
gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Hom...    42   4e-04
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...    40   0.001
gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo...    37   0.012
gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Hom...    37   0.012
gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Hom...    37   0.012
gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo...    37   0.012
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]         37   0.020
gi|223646115 short chain dehydrogenase/reductase family 16C, mem...    36   0.034
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B...    35   0.077
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]           34   0.13 
gi|38679977 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo ...    33   0.17 
gi|38679974 acetyl-Coenzyme A carboxylase alpha isoform 4 [Homo ...    33   0.17 
gi|38679971 acetyl-Coenzyme A carboxylase alpha isoform 3 [Homo ...    33   0.17 
gi|38679967 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo ...    33   0.17 
gi|38679960 acetyl-Coenzyme A carboxylase alpha isoform 1 [Homo ...    33   0.17 
gi|7705421 hydroxysteroid (17-beta) dehydrogenase 7 [Homo sapiens]     33   0.29 
gi|22507405 short chain dehydrogenase/reductase family 9C, membe...    30   1.4  
gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo sapi...    30   1.9  
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo...    30   2.5  

>gi|13375997 dehydrogenase/reductase (SDR family) member 12 isoform
           2 [Homo sapiens]
          Length = 242

 Score =  495 bits (1275), Expect = e-140
 Identities = 242/242 (100%), Positives = 242/242 (100%)

Query: 1   MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKF 60
           MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKF
Sbjct: 1   MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKF 60

Query: 61  VENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPR 120
           VENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPR
Sbjct: 61  VENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPR 120

Query: 121 VITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHP 180
           VITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHP
Sbjct: 121 VITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHP 180

Query: 181 GWADTPGVRQAMPGFHARFGDRLRSEAQGADTMLWLALSSAAAAQPSGRFFQGDFLPGCE 240
           GWADTPGVRQAMPGFHARFGDRLRSEAQGADTMLWLALSSAAAAQPSGRFFQGDFLPGCE
Sbjct: 181 GWADTPGVRQAMPGFHARFGDRLRSEAQGADTMLWLALSSAAAAQPSGRFFQGDFLPGCE 240

Query: 241 GS 242
           GS
Sbjct: 241 GS 242


>gi|72534732 dehydrogenase/reductase (SDR family) member 12 isoform
           1 [Homo sapiens]
          Length = 271

 Score =  382 bits (980), Expect = e-106
 Identities = 186/186 (100%), Positives = 186/186 (100%)

Query: 1   MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKF 60
           MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKF
Sbjct: 1   MNLHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKF 60

Query: 61  VENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPR 120
           VENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPR
Sbjct: 61  VENFKQEHKLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPR 120

Query: 121 VITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHP 180
           VITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHP
Sbjct: 121 VITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHP 180

Query: 181 GWADTP 186
           GWADTP
Sbjct: 181 GWADTP 186


>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
          Length = 318

 Score = 84.7 bits (208), Expect = 6e-17
 Identities = 60/200 (30%), Positives = 104/200 (52%), Gaps = 6/200 (3%)

Query: 25  LEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQEHK-LHVLINNAGCMVNK 83
           +E+   +AK++   + ++ + +  +DLSD K I  F + F  E K LHVLINNAG M+  
Sbjct: 75  VEKGELVAKEIQTTTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCP 134

Query: 84  RELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSER 143
              T DG E +   N LG ++LT  L+  L++    R++ VSS    + +++ ++LQ E+
Sbjct: 135 YSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEK 194

Query: 144 TPFDGTMVYAQNKRQQVVLTERWAQ--GHPAIHFSSMHPGWADTPGVRQA--MPGFHARF 199
             ++  + Y  +K   ++ T+  A+      +   S+HPG   +  VR +  M      F
Sbjct: 195 F-YNAGLAYCHSKLANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLF 253

Query: 200 GDRLRSEAQGADTMLWLALS 219
              +++  QGA T L  AL+
Sbjct: 254 SFFIKTPQQGAQTSLHCALT 273


>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
          Length = 316

 Score = 82.0 bits (201), Expect = 4e-16
 Identities = 67/207 (32%), Positives = 103/207 (49%), Gaps = 11/207 (5%)

Query: 32  AKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQEHK-LHVLINNAGCMVNKRELTEDG 90
           A ++ + + +  + +  +DLSD K I  F E F  E K LH+LINNAG M+     T DG
Sbjct: 80  ASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADG 139

Query: 91  LEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTM 150
            E +   N LG ++LT  L+  L+     RV+ VSS    + K+  +DLQSE+  +    
Sbjct: 140 FETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKR-YSRGF 198

Query: 151 VYAQNKRQQVVLTERWA---QGHPAIHFSSMHPGWADTPGVRQA--MPGFHARFGDRLRS 205
            Y  +K   V+ T   A   QG   +   ++HPG   +  VR +  +      F   +++
Sbjct: 199 AYCHSKLANVLFTRELAKRLQG-TGVTTYAVHPGVVRSELVRHSSLLCLLWRLFSPFVKT 257

Query: 206 EAQGADTMLWLALSSAAAAQP-SGRFF 231
             +GA T L  AL  A   +P SG++F
Sbjct: 258 AREGAQTSLHCAL--AEGLEPLSGKYF 282


>gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo
           sapiens]
          Length = 330

 Score = 77.8 bits (190), Expect = 8e-15
 Identities = 56/142 (39%), Positives = 78/142 (54%), Gaps = 12/142 (8%)

Query: 32  AKQLPLKSPSENI-----FLHIVDLSDPKQIWKFVENFKQEH-KLHVLINNAGCMVNKRE 85
           AKQ+  K   E +     FL+  DL+    I +FV+ FK +   LHVLINNAG M+  + 
Sbjct: 80  AKQVVSKIKEETLNDKVEFLYC-DLASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQR 138

Query: 86  LTEDGLEKNFAANTLGVYILTTGLIPVLEKE----HDPRVITVSSGGMLVQKLNTNDLQS 141
            T DG E++F  N LG ++LT  L+  L++     H  RV+TVSS    V +LN +DLQS
Sbjct: 139 KTRDGFEEHFGLNYLGHFLLTNLLLDTLKESGSPGHSARVVTVSSATHYVAELNMDDLQS 198

Query: 142 ERTPFDGTMVYAQNKRQQVVLT 163
               +     YAQ+K   V+ T
Sbjct: 199 SAC-YSPHAAYAQSKLALVLFT 219


>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score = 74.3 bits (181), Expect = 9e-14
 Identities = 63/208 (30%), Positives = 101/208 (48%), Gaps = 13/208 (6%)

Query: 25  LEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENF-KQEHKLHVLINNAGCMVNK 83
           +E+  A AK +  ++ + ++    +DL+  K I +F     ++E ++ +LINNAG M   
Sbjct: 72  MEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCP 131

Query: 84  RELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSER 143
              TEDG E  F  N LG ++LT  L+  L+     R+I +SS   +   ++ +DL  + 
Sbjct: 132 HWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQT 191

Query: 144 TPFDGTMVYAQNKRQQVVLTE---RWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFG 200
             ++    Y Q+K   V+ T+   R  QG   +  +++HPG A T   R    G H   G
Sbjct: 192 RKYNTKAAYCQSKLAIVLFTKELSRRLQG-SGVTVNALHPGVARTELGRHT--GIH---G 245

Query: 201 DRLRSEAQGADTMLWLALSS-AAAAQPS 227
               S   G   + WL + S   AAQPS
Sbjct: 246 STFSSTTLG--PIFWLLVKSPELAAQPS 271


>gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens]
          Length = 260

 Score = 74.3 bits (181), Expect = 9e-14
 Identities = 63/208 (30%), Positives = 101/208 (48%), Gaps = 13/208 (6%)

Query: 25  LEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENF-KQEHKLHVLINNAGCMVNK 83
           +E+  A AK +  ++ + ++    +DL+  K I +F     ++E ++ +LINNAG M   
Sbjct: 1   MEKCEAAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCP 60

Query: 84  RELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSER 143
              TEDG E  F  N LG ++LT  L+  L+     R+I +SS   +   ++ +DL  + 
Sbjct: 61  HWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQT 120

Query: 144 TPFDGTMVYAQNKRQQVVLTE---RWAQGHPAIHFSSMHPGWADTPGVRQAMPGFHARFG 200
             ++    Y Q+K   V+ T+   R  QG   +  +++HPG A T   R    G H   G
Sbjct: 121 RKYNTKAAYCQSKLAIVLFTKELSRRLQG-SGVTVNALHPGVARTELGRHT--GIH---G 174

Query: 201 DRLRSEAQGADTMLWLALSS-AAAAQPS 227
               S   G   + WL + S   AAQPS
Sbjct: 175 STFSSTTLG--PIFWLLVKSPELAAQPS 200


>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
           sapiens]
          Length = 336

 Score = 70.5 bits (171), Expect = 1e-12
 Identities = 57/192 (29%), Positives = 93/192 (48%), Gaps = 11/192 (5%)

Query: 49  VDLSDPKQIWKFVENFKQEH-KLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTT 107
           +DL+  + +  F +   QE  +L VLINNAG        TEDG E  F  N LG ++LT 
Sbjct: 114 LDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTN 173

Query: 108 GLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWA 167
            L+ +L+     R++ VSS       +N +DL SE++ ++ +  Y+++K   ++ T   A
Sbjct: 174 LLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQS-YNKSFCYSRSKLANILFTRELA 232

Query: 168 QGHPA--IHFSSMHPGWADTPGVRQ------AMPGFHARFGDRLRSEAQGADTMLWLALS 219
           +      +  + +HPG   T   R         P F+       ++  +GA T ++LA S
Sbjct: 233 RRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLA-S 291

Query: 220 SAAAAQPSGRFF 231
           S      SGR+F
Sbjct: 292 SPEVEGVSGRYF 303


>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
           sapiens]
          Length = 414

 Score = 47.4 bits (111), Expect = 1e-05
 Identities = 32/79 (40%), Positives = 42/79 (53%), Gaps = 1/79 (1%)

Query: 49  VDLSDPKQIWKFVENFKQEH-KLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTT 107
           +DL+  + +  F E FK ++  LHVL+ NA        LT+DGLE  F  N LG + L  
Sbjct: 182 LDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQ 241

Query: 108 GLIPVLEKEHDPRVITVSS 126
            L  VL +    RVI VSS
Sbjct: 242 LLQDVLCRSAPARVIVVSS 260


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 45.1 bits (105), Expect = 6e-05
 Identities = 33/105 (31%), Positives = 52/105 (49%), Gaps = 8/105 (7%)

Query: 25  LEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQE-HKLHVLINNAGCMVNK 83
           LEETAA  K L  K     +   +VD S+ + I+   +  K E   + +L+NNAG +   
Sbjct: 73  LEETAAKCKGLGAK-----VHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTS 127

Query: 84  REL-TEDG-LEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSS 126
               T+D  +EK F  N L  +  T   +P + K +   ++TV+S
Sbjct: 128 DLFATQDPQIEKTFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVAS 172


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 44.7 bits (104), Expect = 7e-05
 Identities = 28/105 (26%), Positives = 61/105 (58%), Gaps = 8/105 (7%)

Query: 25  LEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQE-HKLHVLINNAGCMVNK 83
           +EETAA  ++L + + +     ++VD S+ ++I++ +   K+E   + +++NNAG +   
Sbjct: 73  VEETAAECRKLGVTAHA-----YVVDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPA 127

Query: 84  RELT--EDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSS 126
             L+  ++ + K F  N LG + +T  L+P + + +   ++TV+S
Sbjct: 128 DLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVAS 172


>gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Homo
           sapiens]
          Length = 377

 Score = 42.4 bits (98), Expect = 4e-04
 Identities = 54/217 (24%), Positives = 88/217 (40%), Gaps = 12/217 (5%)

Query: 24  SLEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENF-KQEHKLHVLINNAGCMVN 82
           S E   A A  L  +S +  +    +DL+    +  F   F   E +L +LI+NAG  ++
Sbjct: 69  SQERGEAAAFDLRQESGNNEVIFMALDLASLASVRAFATAFLSSEPRLDILIHNAG--IS 126

Query: 83  KRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSE 142
               T +        N +G ++LT  L+P L+     RV+ V+S      +L+   L   
Sbjct: 127 SCGRTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVASAAHCRGRLDFKRLDRP 186

Query: 143 RTPFDGTM-VYAQNKRQQVVLTERWAQGHPA--IHFSSMHPGWADTPGVRQAMPGF---- 195
              +   +  YA  K   V+     A    A  +   + HPG  ++    + +PG+    
Sbjct: 187 VVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPVNSELFLRHVPGWLRPL 246

Query: 196 -HARFGDRLRSEAQGADTMLWLALSSAAAAQPSGRFF 231
                   LR+   GA T L+ AL        SGR+F
Sbjct: 247 LRPLAWLVLRAPRGGAQTPLYCALQEGIEPL-SGRYF 282


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score = 40.4 bits (93), Expect = 0.001
 Identities = 42/161 (26%), Positives = 69/161 (42%), Gaps = 37/161 (22%)

Query: 41  SENIFLHIVDLSDPKQIW---KFVENFKQEHKLHVLINN---AGCMVNKRELTEDGLEKN 94
           S  +   ++D++DP+ +    K+VE   +E  L  L+NN   AG +     LT D  ++ 
Sbjct: 73  SSRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWLTRDDFQRV 132

Query: 95  FAANTLGVYILTTGLIPVLEKEHDPRVITVSS---------GGMLVQKLNTNDLQSERTP 145
              NT+G   +T  L+P+L++    RVI ++S         GG  V K            
Sbjct: 133 LNVNTMGPIGVTLALLPLLQQARG-RVINITSVLGRLAANGGGYCVSKF----------- 180

Query: 146 FDGTMVYAQNKRQQVVLTERWAQGHPAIHFSSMHPGWADTP 186
             G   ++ + R+ V         H  I  S + PG+  TP
Sbjct: 181 --GLEAFSDSLRRDV--------AHFGIRVSIVEPGFFRTP 211


>gi|40548397 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 37.4 bits (85), Expect = 0.012
 Identities = 30/107 (28%), Positives = 50/107 (46%), Gaps = 4/107 (3%)

Query: 25  LEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNA---GCMV 81
           L E+ + A +         + L + D  + K+  ++V+N   E  L  LINNA   G + 
Sbjct: 61  LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120

Query: 82  NKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGG 128
               LT +   +    N  G+  +T  ++P+++K    RVI VSS G
Sbjct: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQG-RVINVSSVG 166


>gi|214010158 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 37.4 bits (85), Expect = 0.012
 Identities = 30/107 (28%), Positives = 50/107 (46%), Gaps = 4/107 (3%)

Query: 25  LEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNA---GCMV 81
           L E+ + A +         + L + D  + K+  ++V+N   E  L  LINNA   G + 
Sbjct: 61  LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120

Query: 82  NKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGG 128
               LT +   +    N  G+  +T  ++P+++K    RVI VSS G
Sbjct: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQG-RVINVSSVG 166


>gi|214010156 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 37.4 bits (85), Expect = 0.012
 Identities = 30/107 (28%), Positives = 50/107 (46%), Gaps = 4/107 (3%)

Query: 25  LEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNA---GCMV 81
           L E+ + A +         + L + D  + K+  ++V+N   E  L  LINNA   G + 
Sbjct: 61  LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120

Query: 82  NKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGG 128
               LT +   +    N  G+  +T  ++P+++K    RVI VSS G
Sbjct: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQG-RVINVSSVG 166


>gi|22758144 NADP-dependent retinol dehydrogenase/reductase [Homo
           sapiens]
          Length = 319

 Score = 37.4 bits (85), Expect = 0.012
 Identities = 30/107 (28%), Positives = 50/107 (46%), Gaps = 4/107 (3%)

Query: 25  LEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNA---GCMV 81
           L E+ + A +         + L + D  + K+  ++V+N   E  L  LINNA   G + 
Sbjct: 61  LTESGSTALKAETSERLRTVLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGVLA 120

Query: 82  NKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGG 128
               LT +   +    N  G+  +T  ++P+++K    RVI VSS G
Sbjct: 121 PTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQG-RVINVSSVG 166


>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
          Length = 418

 Score = 36.6 bits (83), Expect = 0.020
 Identities = 24/81 (29%), Positives = 39/81 (48%), Gaps = 3/81 (3%)

Query: 48  IVDLSDPKQIWKFVEN-FKQEHKLHVLINNAGC--MVNKRELTEDGLEKNFAANTLGVYI 104
           IVD+ D +QI   VE   K+   + +L+NNA    + N  +     L+     NT G Y+
Sbjct: 72  IVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTRGTYL 131

Query: 105 LTTGLIPVLEKEHDPRVITVS 125
            +   IP L+K     ++ +S
Sbjct: 132 ASKACIPYLKKSKVAHILNIS 152


>gi|223646115 short chain dehydrogenase/reductase family 16C, member
           6 [Homo sapiens]
          Length = 323

 Score = 35.8 bits (81), Expect = 0.034
 Identities = 22/103 (21%), Positives = 52/103 (50%), Gaps = 7/103 (6%)

Query: 27  ETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQEH-KLHVLINNAGCMVNKR- 84
           ET  LAK+       + +F +  D S+ +++++  +  ++E   + +L+NNA  +  K  
Sbjct: 75  ETCRLAKE----KGGKKVFPYTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPF 130

Query: 85  -ELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSS 126
            ++ +  +EK+F  N +  +      +P + K +   ++ +SS
Sbjct: 131 LDIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISS 173


>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
           [Homo sapiens]
          Length = 264

 Score = 34.7 bits (78), Expect = 0.077
 Identities = 18/72 (25%), Positives = 39/72 (54%), Gaps = 2/72 (2%)

Query: 57  IWKFVENFKQEHKLHVLINNAGCMVNKRELT--EDGLEKNFAANTLGVYILTTGLIPVLE 114
           +W   +  K+   + +++NNAG +     L+  ++ + K F  N LG + +T  L+P + 
Sbjct: 65  LWDINKVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMM 124

Query: 115 KEHDPRVITVSS 126
           + +   ++TV+S
Sbjct: 125 ERNHGHIVTVAS 136


>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
          Length = 309

 Score = 33.9 bits (76), Expect = 0.13
 Identities = 27/111 (24%), Positives = 52/111 (46%), Gaps = 14/111 (12%)

Query: 26  EETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVENFKQE-HKLHVLINNAGCMVNKR 84
           EET  +A++    + +  +  +  D S  + +++  +  K+E   + +LINNAG +  K+
Sbjct: 78  EETCKMARE----AGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKK 133

Query: 85  ------ELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDPRVITVSSGGM 129
                 EL E   + NF A+   ++     L  ++  +H   V   SS G+
Sbjct: 134 FLDCPDELMEKSFDVNFKAH---LWTYKAFLPAMIANDHGHLVCISSSAGL 181


>gi|38679977 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo
           sapiens]
          Length = 2346

 Score = 33.5 bits (75), Expect = 0.17
 Identities = 55/196 (28%), Positives = 87/196 (44%), Gaps = 31/196 (15%)

Query: 3   LHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVE 62
           LHV  +SL    S FL     SLE    L        P+  + L+ VD+    +  K+V 
Sbjct: 637 LHVADVSLRNSVSNFLH----SLERGQVL--------PAHTL-LNTVDVELIYEGVKYVL 683

Query: 63  NF-KQEHKLHVLINNAGCM-VNKRELTEDGLEKNFAANTLGVYI--------LTTG-LIP 111
              +Q    +V+I N  C+ V+   L++ GL  ++  ++   Y+        +T G    
Sbjct: 684 KVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTC 743

Query: 112 VLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHP 171
           V EKE+DP V+   S G L+Q +    ++     F G   YA+ +  ++V+T   A    
Sbjct: 744 VFEKENDPSVMRSPSAGKLIQYI----VEDGGHVFAG-QCYAEIEVMKMVMT-LTAVESG 797

Query: 172 AIHFSSMHPGWADTPG 187
            IH+    PG A  PG
Sbjct: 798 CIHYVK-RPGAALDPG 812


>gi|38679974 acetyl-Coenzyme A carboxylase alpha isoform 4 [Homo
           sapiens]
          Length = 2268

 Score = 33.5 bits (75), Expect = 0.17
 Identities = 55/196 (28%), Positives = 87/196 (44%), Gaps = 31/196 (15%)

Query: 3   LHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVE 62
           LHV  +SL    S FL     SLE    L        P+  + L+ VD+    +  K+V 
Sbjct: 559 LHVADVSLRNSVSNFLH----SLERGQVL--------PAHTL-LNTVDVELIYEGVKYVL 605

Query: 63  NF-KQEHKLHVLINNAGCM-VNKRELTEDGLEKNFAANTLGVYI--------LTTG-LIP 111
              +Q    +V+I N  C+ V+   L++ GL  ++  ++   Y+        +T G    
Sbjct: 606 KVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTC 665

Query: 112 VLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHP 171
           V EKE+DP V+   S G L+Q +    ++     F G   YA+ +  ++V+T   A    
Sbjct: 666 VFEKENDPSVMRSPSAGKLIQYI----VEDGGHVFAG-QCYAEIEVMKMVMT-LTAVESG 719

Query: 172 AIHFSSMHPGWADTPG 187
            IH+    PG A  PG
Sbjct: 720 CIHYVK-RPGAALDPG 734


>gi|38679971 acetyl-Coenzyme A carboxylase alpha isoform 3 [Homo
           sapiens]
          Length = 2288

 Score = 33.5 bits (75), Expect = 0.17
 Identities = 55/196 (28%), Positives = 87/196 (44%), Gaps = 31/196 (15%)

Query: 3   LHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVE 62
           LHV  +SL    S FL     SLE    L        P+  + L+ VD+    +  K+V 
Sbjct: 579 LHVADVSLRNSVSNFLH----SLERGQVL--------PAHTL-LNTVDVELIYEGVKYVL 625

Query: 63  NF-KQEHKLHVLINNAGCM-VNKRELTEDGLEKNFAANTLGVYI--------LTTG-LIP 111
              +Q    +V+I N  C+ V+   L++ GL  ++  ++   Y+        +T G    
Sbjct: 626 KVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTC 685

Query: 112 VLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHP 171
           V EKE+DP V+   S G L+Q +    ++     F G   YA+ +  ++V+T   A    
Sbjct: 686 VFEKENDPSVMRSPSAGKLIQYI----VEDGGHVFAG-QCYAEIEVMKMVMT-LTAVESG 739

Query: 172 AIHFSSMHPGWADTPG 187
            IH+    PG A  PG
Sbjct: 740 CIHYVK-RPGAALDPG 754


>gi|38679967 acetyl-Coenzyme A carboxylase alpha isoform 2 [Homo
           sapiens]
          Length = 2346

 Score = 33.5 bits (75), Expect = 0.17
 Identities = 55/196 (28%), Positives = 87/196 (44%), Gaps = 31/196 (15%)

Query: 3   LHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVE 62
           LHV  +SL    S FL     SLE    L        P+  + L+ VD+    +  K+V 
Sbjct: 637 LHVADVSLRNSVSNFLH----SLERGQVL--------PAHTL-LNTVDVELIYEGVKYVL 683

Query: 63  NF-KQEHKLHVLINNAGCM-VNKRELTEDGLEKNFAANTLGVYI--------LTTG-LIP 111
              +Q    +V+I N  C+ V+   L++ GL  ++  ++   Y+        +T G    
Sbjct: 684 KVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTC 743

Query: 112 VLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHP 171
           V EKE+DP V+   S G L+Q +    ++     F G   YA+ +  ++V+T   A    
Sbjct: 744 VFEKENDPSVMRSPSAGKLIQYI----VEDGGHVFAG-QCYAEIEVMKMVMT-LTAVESG 797

Query: 172 AIHFSSMHPGWADTPG 187
            IH+    PG A  PG
Sbjct: 798 CIHYVK-RPGAALDPG 812


>gi|38679960 acetyl-Coenzyme A carboxylase alpha isoform 1 [Homo
           sapiens]
          Length = 2383

 Score = 33.5 bits (75), Expect = 0.17
 Identities = 55/196 (28%), Positives = 87/196 (44%), Gaps = 31/196 (15%)

Query: 3   LHVKTLSLMTWRSRFLEESFWSLEETAALAKQLPLKSPSENIFLHIVDLSDPKQIWKFVE 62
           LHV  +SL    S FL     SLE    L        P+  + L+ VD+    +  K+V 
Sbjct: 674 LHVADVSLRNSVSNFLH----SLERGQVL--------PAHTL-LNTVDVELIYEGVKYVL 720

Query: 63  NF-KQEHKLHVLINNAGCM-VNKRELTEDGLEKNFAANTLGVYI--------LTTG-LIP 111
              +Q    +V+I N  C+ V+   L++ GL  ++  ++   Y+        +T G    
Sbjct: 721 KVTRQSPNSYVVIMNGSCVEVDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTC 780

Query: 112 VLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWAQGHP 171
           V EKE+DP V+   S G L+Q +    ++     F G   YA+ +  ++V+T   A    
Sbjct: 781 VFEKENDPSVMRSPSAGKLIQYI----VEDGGHVFAG-QCYAEIEVMKMVMT-LTAVESG 834

Query: 172 AIHFSSMHPGWADTPG 187
            IH+    PG A  PG
Sbjct: 835 CIHYVK-RPGAALDPG 849


>gi|7705421 hydroxysteroid (17-beta) dehydrogenase 7 [Homo sapiens]
          Length = 341

 Score = 32.7 bits (73), Expect = 0.29
 Identities = 20/75 (26%), Positives = 34/75 (45%), Gaps = 1/75 (1%)

Query: 70  LHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTTGLIPVLEKEHDP-RVITVSSGG 128
           +H+     G +    ++T DGL++ F  N  G +IL   L P+L    +P ++I  SS  
Sbjct: 114 IHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWTSSRS 173

Query: 129 MLVQKLNTNDLQSER 143
                 +  D Q  +
Sbjct: 174 ARKSNFSLEDFQHSK 188


>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
           [Homo sapiens]
          Length = 313

 Score = 30.4 bits (67), Expect = 1.4
 Identities = 23/90 (25%), Positives = 42/90 (46%), Gaps = 4/90 (4%)

Query: 42  ENIFLHIVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNKRE---LTEDGLEKNFAAN 98
           +   L +      K   ++V +   E  L  L+NNAG  +       LT+D   K    N
Sbjct: 74  QTTLLDVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVN 133

Query: 99  TLGVYILTTGLIPVLEKEHDPRVITVSSGG 128
            +G+  +T  ++P++++    RV+ +SS G
Sbjct: 134 LVGLIEVTLHMLPMVKRARG-RVVNMSSSG 162


>gi|119392083 hydroxysteroid (11-beta) dehydrogenase 2 [Homo
           sapiens]
          Length = 405

 Score = 30.0 bits (66), Expect = 1.9
 Identities = 36/112 (32%), Positives = 51/112 (45%), Gaps = 18/112 (16%)

Query: 31  LAKQLPLKSP---------SENIFLHIVDLSDPKQIWKFVENFKQEHK----LHVLINNA 77
           LA  L L SP         S  + L  +DL+ P  I + +E F + H     L  L+NNA
Sbjct: 110 LATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLE-FTKAHTTSTGLWGLVNNA 168

Query: 78  GC--MVNKRELTEDGLEKN-FAANTLGVYILTTGLIPVLEKEHDPRVITVSS 126
           G   +V   EL+     ++    N  G   LT GL+P+L      R++TV S
Sbjct: 169 GHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRG-RIVTVGS 219


>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
           sapiens]
          Length = 330

 Score = 29.6 bits (65), Expect = 2.5
 Identities = 21/88 (23%), Positives = 43/88 (48%), Gaps = 12/88 (13%)

Query: 48  IVDLSDPKQIWKFVENFKQEHKLHVLINNAGCMVNK----RELTEDGL----EKNFAANT 99
           + D S  ++I+  +    ++  + +L+NN G          +L+ED L      N AA +
Sbjct: 123 VADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAAS 182

Query: 100 LGVYILTTGLIPVLEKEHDPRVITVSSG 127
           L V+++  G++    +     ++T+SSG
Sbjct: 183 LMVHVVLPGMV----ERKKGAIVTISSG 206


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,625,022
Number of Sequences: 37866
Number of extensions: 416766
Number of successful extensions: 926
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 901
Number of HSP's gapped (non-prelim): 40
length of query: 242
length of database: 18,247,518
effective HSP length: 99
effective length of query: 143
effective length of database: 14,498,784
effective search space: 2073326112
effective search space used: 2073326112
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 60 (27.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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