Guide to the Human Genome
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Search of human proteins with 13325070

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase
isoform b [Homo sapiens]
         (893 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase iso...  1820   0.0  
gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase iso...  1813   0.0  
gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precurs...   787   0.0  
gi|26190608 synaptojanin 2 [Homo sapiens]                             223   6e-58
gi|237757312 synaptojanin 1 isoform c [Homo sapiens]                  206   8e-53
gi|237757310 synaptojanin 1 isoform a [Homo sapiens]                  206   8e-53
gi|237757308 synaptojanin 1 isoform b [Homo sapiens]                  206   8e-53
gi|237757326 synaptojanin 1 isoform d [Homo sapiens]                  206   8e-53
gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatas...   174   4e-43
gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sap...   167   4e-41
gi|40254823 SH2 containing inositol phosphatase isoform b [Homo ...   162   1e-39
gi|64085167 SH2 containing inositol phosphatase isoform a [Homo ...   162   1e-39
gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Ho...   151   3e-36
gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [H...   138   2e-32
gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Ho...   138   2e-32
gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens]     115   2e-25
gi|56119110 family with sequence similarity 13, member A1 isofor...    67   1e-10
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]             64   8e-10
gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo sa...    62   2e-09
gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo sa...    62   2e-09
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa...    62   2e-09
gi|226423858 PRR5-ARHGAP8 fusion protein [Homo sapiens]                60   9e-09
gi|66346660 Rho GTPase activating protein 8 isoform 2 [Homo sapi...    60   9e-09
gi|66346662 Rho GTPase activating protein 8 isoform 1 [Homo sapi...    60   9e-09
gi|4757980 beta chimerin isoform 2 [Homo sapiens]                      55   2e-07
gi|91106928 beta chimerin isoform 1 [Homo sapiens]                     55   2e-07
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]        55   2e-07
gi|55770898 Rho GTPase activating protein 25 isoform a [Homo sap...    54   5e-07
gi|7661882 Rho GTPase activating protein 25 isoform b [Homo sapi...    54   5e-07
gi|134304853 PTPL1-associated RhoGAP 1 [Homo sapiens]                  54   8e-07

>gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase
           isoform b [Homo sapiens]
          Length = 893

 Score = 1820 bits (4715), Expect = 0.0
 Identities = 893/893 (100%), Positives = 893/893 (100%)

Query: 1   MEPPLPVGAQPLATVEGMEMKGPLREPCALTLAQRNGQYELIIQLHEKEQHVQDIIPINS 60
           MEPPLPVGAQPLATVEGMEMKGPLREPCALTLAQRNGQYELIIQLHEKEQHVQDIIPINS
Sbjct: 1   MEPPLPVGAQPLATVEGMEMKGPLREPCALTLAQRNGQYELIIQLHEKEQHVQDIIPINS 60

Query: 61  HFRCVQEAEETLLIDIASNSGCKIRVQGDWIRERRFEIPDEEHCLKFLSAVLAAQKAQSQ 120
           HFRCVQEAEETLLIDIASNSGCKIRVQGDWIRERRFEIPDEEHCLKFLSAVLAAQKAQSQ
Sbjct: 61  HFRCVQEAEETLLIDIASNSGCKIRVQGDWIRERRFEIPDEEHCLKFLSAVLAAQKAQSQ 120

Query: 121 LLVPEQKDSSSWYQKLDTKDKPSVFSGLLGFEDNFSSMNLDKKINSQNQPTGIHREPPPP 180
           LLVPEQKDSSSWYQKLDTKDKPSVFSGLLGFEDNFSSMNLDKKINSQNQPTGIHREPPPP
Sbjct: 121 LLVPEQKDSSSWYQKLDTKDKPSVFSGLLGFEDNFSSMNLDKKINSQNQPTGIHREPPPP 180

Query: 181 PFSVNKMLPREKEASNKEQPKVTNTMRKLFVPNTQSGQREGLIKHILAKREKEYVNIQTF 240
           PFSVNKMLPREKEASNKEQPKVTNTMRKLFVPNTQSGQREGLIKHILAKREKEYVNIQTF
Sbjct: 181 PFSVNKMLPREKEASNKEQPKVTNTMRKLFVPNTQSGQREGLIKHILAKREKEYVNIQTF 240

Query: 241 RFFVGTWNVNGQSPDSGLEPWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMA 300
           RFFVGTWNVNGQSPDSGLEPWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMA
Sbjct: 241 RFFVGTWNVNGQSPDSGLEPWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMA 300

Query: 301 VERGLHSKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAV 360
           VERGLHSKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAV
Sbjct: 301 VERGLHSKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAV 360

Query: 361 RFVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWL 420
           RFVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWL
Sbjct: 361 RFVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWL 420

Query: 421 GDLNYRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYD 480
           GDLNYRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYD
Sbjct: 421 GDLNYRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYD 480

Query: 481 SKTDRWDSSGKCRVPAWCDRILWRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDE 540
           SKTDRWDSSGKCRVPAWCDRILWRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDE
Sbjct: 481 SKTDRWDSSGKCRVPAWCDRILWRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDE 540

Query: 541 RRYRKVFEDSVRIMDRMENDFLPSLELSRREFVFENVKFRQLQKEKFQISNNGQVPCHFS 600
           RRYRKVFEDSVRIMDRMENDFLPSLELSRREFVFENVKFRQLQKEKFQISNNGQVPCHFS
Sbjct: 541 RRYRKVFEDSVRIMDRMENDFLPSLELSRREFVFENVKFRQLQKEKFQISNNGQVPCHFS 600

Query: 601 FIPKLNDSQYCKPWLRAEPFEGYLEPNETVDISLDVYVSKDSVTILNSGEDKIEDILVLH 660
           FIPKLNDSQYCKPWLRAEPFEGYLEPNETVDISLDVYVSKDSVTILNSGEDKIEDILVLH
Sbjct: 601 FIPKLNDSQYCKPWLRAEPFEGYLEPNETVDISLDVYVSKDSVTILNSGEDKIEDILVLH 660

Query: 661 LDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVTKLIDLEKSLLQMVPLDEGAS 720
           LDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVTKLIDLEKSLLQMVPLDEGAS
Sbjct: 661 LDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVTKLIDLEKSLLQMVPLDEGAS 720

Query: 721 ERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSNHSVA 780
           ERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSNHSVA
Sbjct: 721 ERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSNHSVA 780

Query: 781 EALLIFLEALPEPVICYELYQRCLDSAYDPRICRQVISQLPRCHRNVFRYLMAFLRELLK 840
           EALLIFLEALPEPVICYELYQRCLDSAYDPRICRQVISQLPRCHRNVFRYLMAFLRELLK
Sbjct: 781 EALLIFLEALPEPVICYELYQRCLDSAYDPRICRQVISQLPRCHRNVFRYLMAFLRELLK 840

Query: 841 FSEYNSVNANMIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLGFLLGSEED 893
           FSEYNSVNANMIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLGFLLGSEED
Sbjct: 841 FSEYNSVNANMIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLGFLLGSEED 893


>gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase
           isoform a [Homo sapiens]
          Length = 901

 Score = 1813 bits (4696), Expect = 0.0
 Identities = 893/901 (99%), Positives = 893/901 (99%), Gaps = 8/901 (0%)

Query: 1   MEPPLPVGAQPLATVEGMEMKGPLREPCALTLAQRNGQYELIIQLHEKEQHVQDIIPINS 60
           MEPPLPVGAQPLATVEGMEMKGPLREPCALTLAQRNGQYELIIQLHEKEQHVQDIIPINS
Sbjct: 1   MEPPLPVGAQPLATVEGMEMKGPLREPCALTLAQRNGQYELIIQLHEKEQHVQDIIPINS 60

Query: 61  HFRCVQEAEETLLIDIASNSGCKIRVQGDWIRERRFEIPDEEHCLKFLSAVLAAQKAQSQ 120
           HFRCVQEAEETLLIDIASNSGCKIRVQGDWIRERRFEIPDEEHCLKFLSAVLAAQKAQSQ
Sbjct: 61  HFRCVQEAEETLLIDIASNSGCKIRVQGDWIRERRFEIPDEEHCLKFLSAVLAAQKAQSQ 120

Query: 121 LLVPEQKDSSSWYQKLDTKDKPSVFSGLLGFEDNFSSMNLDKKINSQNQPTGIHREPPPP 180
           LLVPEQKDSSSWYQKLDTKDKPSVFSGLLGFEDNFSSMNLDKKINSQNQPTGIHREPPPP
Sbjct: 121 LLVPEQKDSSSWYQKLDTKDKPSVFSGLLGFEDNFSSMNLDKKINSQNQPTGIHREPPPP 180

Query: 181 PFSVNKMLPREKEASNKEQPKVTNTMRKLFVPNTQSGQREGLIKHILAKREKEYVNIQTF 240
           PFSVNKMLPREKEASNKEQPKVTNTMRKLFVPNTQSGQREGLIKHILAKREKEYVNIQTF
Sbjct: 181 PFSVNKMLPREKEASNKEQPKVTNTMRKLFVPNTQSGQREGLIKHILAKREKEYVNIQTF 240

Query: 241 RFFVGTWNVNGQSPDSGLEPWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMA 300
           RFFVGTWNVNGQSPDSGLEPWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMA
Sbjct: 241 RFFVGTWNVNGQSPDSGLEPWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMA 300

Query: 301 VERGLHSKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAV 360
           VERGLHSKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAV
Sbjct: 301 VERGLHSKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAV 360

Query: 361 RFVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWL 420
           RFVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWL
Sbjct: 361 RFVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWL 420

Query: 421 GDLNYRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYD 480
           GDLNYRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYD
Sbjct: 421 GDLNYRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYD 480

Query: 481 SKTDRWDSSGKCRVPAWCDRILWRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDE 540
           SKTDRWDSSGKCRVPAWCDRILWRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDE
Sbjct: 481 SKTDRWDSSGKCRVPAWCDRILWRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDE 540

Query: 541 RRYRKVFEDSVRIMDRMENDFLPSLELSRREFVFENVKFRQLQKEKFQISNNGQVPCHFS 600
           RRYRKVFEDSVRIMDRMENDFLPSLELSRREFVFENVKFRQLQKEKFQISNNGQVPCHFS
Sbjct: 541 RRYRKVFEDSVRIMDRMENDFLPSLELSRREFVFENVKFRQLQKEKFQISNNGQVPCHFS 600

Query: 601 FIPKLNDSQYCKPWLRAEPFEGYLEPNETVDISLDVYVSKDSVTILNSGEDKIEDILVLH 660
           FIPKLNDSQYCKPWLRAEPFEGYLEPNETVDISLDVYVSKDSVTILNSGEDKIEDILVLH
Sbjct: 601 FIPKLNDSQYCKPWLRAEPFEGYLEPNETVDISLDVYVSKDSVTILNSGEDKIEDILVLH 660

Query: 661 LDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVTKLIDL--------EKSLLQM 712
           LDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVTKLIDL        EKSLLQM
Sbjct: 661 LDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVTKLIDLEEDSFLEKEKSLLQM 720

Query: 713 VPLDEGASERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETI 772
           VPLDEGASERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETI
Sbjct: 721 VPLDEGASERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETI 780

Query: 773 PGSNHSVAEALLIFLEALPEPVICYELYQRCLDSAYDPRICRQVISQLPRCHRNVFRYLM 832
           PGSNHSVAEALLIFLEALPEPVICYELYQRCLDSAYDPRICRQVISQLPRCHRNVFRYLM
Sbjct: 781 PGSNHSVAEALLIFLEALPEPVICYELYQRCLDSAYDPRICRQVISQLPRCHRNVFRYLM 840

Query: 833 AFLRELLKFSEYNSVNANMIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLGFLLGSEE 892
           AFLRELLKFSEYNSVNANMIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLGFLLGSEE
Sbjct: 841 AFLRELLKFSEYNSVNANMIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLGFLLGSEE 900

Query: 893 D 893
           D
Sbjct: 901 D 901


>gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precursor
           [Homo sapiens]
          Length = 913

 Score =  787 bits (2033), Expect = 0.0
 Identities = 387/748 (51%), Positives = 528/748 (70%), Gaps = 32/748 (4%)

Query: 150 GFEDNFSSMNLDKKINSQNQPTGIHREPPPPPFSVNKMLPREKEASNKEQPKVTNTMR-- 207
           G   N   + +D+    Q++P  +               PR+    NK + ++T+ +R  
Sbjct: 184 GLRPNGKGVPMDQSSRGQDKPESLQ--------------PRQ----NKSKSEITDMVRSS 225

Query: 208 ------KLFVPNTQS-GQREGLIKHILAKREKEYVNIQTFRFFVGTWNVNGQSPDSGLEP 260
                 K  + + Q  G R+ ++K  L ++E++Y  IQ FRFF GT+NVNGQSP   L  
Sbjct: 226 TITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRL 285

Query: 261 WLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLV 320
           WL+     PD+YC+GFQELDLS EAFF+ ++ KE+EW  AV  GLH  AKY KV+L+RLV
Sbjct: 286 WLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLV 345

Query: 321 GMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHV 380
           G+MLL++ +++   YI ++  ETVGTGIMG+MGNKGGVA+RF FHNT+ C+VNSHLAAH+
Sbjct: 346 GIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHI 405

Query: 381 EDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLIN 440
           E++ERRNQDYKDIC+RM F  P+ +LP L I  H+V++WLGDLNYR+   D  +VK LI 
Sbjct: 406 EEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKVKKLIE 465

Query: 441 KKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDR 500
           +KD Q L  +DQL IQ   K  F  F EGE+ F PTYKYD+ +D WD+S KCR PAWCDR
Sbjct: 466 EKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDR 525

Query: 501 ILWRGTNVNQLNYRSHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDSVRIMDRMEND 560
           ILW+G N+ QL+Y+SHM LKTSDHKPVS++F IGV+VV++  YRK  E+ VR +D+MEN 
Sbjct: 526 ILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENA 585

Query: 561 FLPSLELSRREFVFENVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDSQYCKPWLRAEPF 620
            +PS+ LS+REF F+NVK+ QL+ E F I +NGQVPCHF FI K ++  YCK WL A P 
Sbjct: 586 NIPSVSLSKREFCFQNVKYMQLKVESFTI-HNGQVPCHFEFINKPDEESYCKQWLNANPS 644

Query: 621 EGYLEPNETVDISLDVYVSKDSVTILNSGEDKIEDILVLHLDRGKDYFLTISGNYLPSCF 680
            G+L P+  V+I L+++V+K + T LNSGEDKIEDILVLHLDRGKDYFL++SGNYLPSCF
Sbjct: 645 RGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCF 704

Query: 681 GTSLEALCRMKRPIREVPVTKLIDLEKSLLQMVPLDEGAS-ERPLQVPKEIWLLVDHLFK 739
           G+ +  LC M+ PI ++P+  + +L  +L+ +   D+G+  + P+++PKE+W++VD+L++
Sbjct: 705 GSPIHTLCYMREPILDLPLETISEL--TLMPVWTGDDGSQLDSPMEIPKELWMMVDYLYR 762

Query: 740 YACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSNHSVAEALLIFLEALPEPVICYEL 799
            A  QEDLFQ PG++ E + I DCLDT + + +  SNHSVAEALL+FLE+LPEPVICY  
Sbjct: 763 NAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICYST 822

Query: 800 YQRCLDSAYDPRICRQVISQLPRCHRNVFRYLMAFLRELLKFSEYNSVNANMIATLFTSL 859
           Y  CL+ + +    +QVIS LP  H+NVF YLMAFLRELLK S  N ++ N++A++F SL
Sbjct: 823 YHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSL 882

Query: 860 LLRPPPNLMARQTPSDRQRAIQFLLGFL 887
           LLR P     +   +++++A +F+  FL
Sbjct: 883 LLRNPAG-HQKLDMTEKKKAQEFIHQFL 909


>gi|26190608 synaptojanin 2 [Homo sapiens]
          Length = 1496

 Score =  223 bits (568), Expect = 6e-58
 Identities = 127/371 (34%), Positives = 192/371 (51%), Gaps = 55/371 (14%)

Query: 227 LAKREKEYVNIQTFRFFVGTWNVNGQSP-------DSGLEPWL------------NCDPN 267
           + +R+ E+ N +  R  +GTWNVNG           + L  WL              D +
Sbjct: 517 MTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSS 576

Query: 268 PPDIYCIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLI 326
           P DI+ +GF+E+ +LS        +  ++ W   +++ +    +Y  +   +LVG+ L I
Sbjct: 577 PADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYI 636

Query: 327 FARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERR 386
           F R     +IRD+A +TV TG+ GK GNKG V +RF FH+T+FC + SHL A     + R
Sbjct: 637 FVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKER 696

Query: 387 NQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQR 446
           N+DYK+I  ++ F +        N+  H+ V W GD NYR+ +    EV   + ++D ++
Sbjct: 697 NEDYKEITQKLCFPMGR------NVFSHDYVFWCGDFNYRIDL-TYEEVFYFVKRQDWKK 749

Query: 447 LLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILW--- 503
           LL+FDQL +Q++  K F DF+EG I F PTYKYD  +  +D+S KCR PAW DR+LW   
Sbjct: 750 LLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRK 809

Query: 504 ------------------------RGT-NVNQLNYRSHMELKTSDHKPVSALFHIGVKVV 538
                                   R T +   L Y    EL+ SDH+PV A+  + V+ V
Sbjct: 810 KHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEV 869

Query: 539 DERRYRKVFED 549
           D     +VF++
Sbjct: 870 DVGARERVFQE 880


>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
          Length = 1295

 Score =  206 bits (524), Expect = 8e-53
 Identities = 125/388 (32%), Positives = 194/388 (50%), Gaps = 56/388 (14%)

Query: 233 EYVNIQTFRFFVGTWNVNGQSP-------DSGLEPWLNCDPN-------------PPDIY 272
           +Y   +  R  VGTWNVNG          +  L  WL   P              P DI+
Sbjct: 526 KYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIF 585

Query: 273 CIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLIFARKD 331
            IGF+E+ +L+        +  ++ W++ +++ +    KY  +   +LVG+ L +F R  
Sbjct: 586 AIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQ 645

Query: 332 QCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQDYK 391
              +IRD+A +TV TG+ G  GNKG VA+R +FH T+ C V SH AA     + RN+D+ 
Sbjct: 646 HAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFI 705

Query: 392 DICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQRLLKFD 451
           +I  ++SF +         +  H+ V W GD NYR+ +P+  EVK LI +++   L+  D
Sbjct: 706 EIARKLSFPMGRM------LFSHDYVFWCGDFNYRIDLPN-EEVKELIRQQNWDSLIAGD 758

Query: 452 QLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWR------- 504
           QL  Q+   + F  F EG++ F PTYKYD  +D +D+S KCR PAW DR+LWR       
Sbjct: 759 QLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFD 818

Query: 505 --GTNVNQLN-------------------YRSHMELKTSDHKPVSALFHIGVKVVDERRY 543
               +++ LN                   +    ELKTSDH+PV AL  I +  V+    
Sbjct: 819 RSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEER 878

Query: 544 RKVFEDSVRIMDRMENDFLPSLELSRRE 571
           + ++++ + +    +   L S++ S  E
Sbjct: 879 QNIYKEVIAVQGPPDGTVLVSIKSSLPE 906


>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
          Length = 1612

 Score =  206 bits (524), Expect = 8e-53
 Identities = 125/388 (32%), Positives = 194/388 (50%), Gaps = 56/388 (14%)

Query: 233 EYVNIQTFRFFVGTWNVNGQSP-------DSGLEPWLNCDPN-------------PPDIY 272
           +Y   +  R  VGTWNVNG          +  L  WL   P              P DI+
Sbjct: 565 KYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIF 624

Query: 273 CIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLIFARKD 331
            IGF+E+ +L+        +  ++ W++ +++ +    KY  +   +LVG+ L +F R  
Sbjct: 625 AIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQ 684

Query: 332 QCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQDYK 391
              +IRD+A +TV TG+ G  GNKG VA+R +FH T+ C V SH AA     + RN+D+ 
Sbjct: 685 HAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFI 744

Query: 392 DICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQRLLKFD 451
           +I  ++SF +         +  H+ V W GD NYR+ +P+  EVK LI +++   L+  D
Sbjct: 745 EIARKLSFPMGRM------LFSHDYVFWCGDFNYRIDLPN-EEVKELIRQQNWDSLIAGD 797

Query: 452 QLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWR------- 504
           QL  Q+   + F  F EG++ F PTYKYD  +D +D+S KCR PAW DR+LWR       
Sbjct: 798 QLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFD 857

Query: 505 --GTNVNQLN-------------------YRSHMELKTSDHKPVSALFHIGVKVVDERRY 543
               +++ LN                   +    ELKTSDH+PV AL  I +  V+    
Sbjct: 858 RSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEER 917

Query: 544 RKVFEDSVRIMDRMENDFLPSLELSRRE 571
           + ++++ + +    +   L S++ S  E
Sbjct: 918 QNIYKEVIAVQGPPDGTVLVSIKSSLPE 945


>gi|237757308 synaptojanin 1 isoform b [Homo sapiens]
          Length = 1350

 Score =  206 bits (524), Expect = 8e-53
 Identities = 125/388 (32%), Positives = 194/388 (50%), Gaps = 56/388 (14%)

Query: 233 EYVNIQTFRFFVGTWNVNGQSP-------DSGLEPWLNCDPN-------------PPDIY 272
           +Y   +  R  VGTWNVNG          +  L  WL   P              P DI+
Sbjct: 565 KYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIF 624

Query: 273 CIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLIFARKD 331
            IGF+E+ +L+        +  ++ W++ +++ +    KY  +   +LVG+ L +F R  
Sbjct: 625 AIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQ 684

Query: 332 QCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQDYK 391
              +IRD+A +TV TG+ G  GNKG VA+R +FH T+ C V SH AA     + RN+D+ 
Sbjct: 685 HAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFI 744

Query: 392 DICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQRLLKFD 451
           +I  ++SF +         +  H+ V W GD NYR+ +P+  EVK LI +++   L+  D
Sbjct: 745 EIARKLSFPMGRM------LFSHDYVFWCGDFNYRIDLPN-EEVKELIRQQNWDSLIAGD 797

Query: 452 QLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWR------- 504
           QL  Q+   + F  F EG++ F PTYKYD  +D +D+S KCR PAW DR+LWR       
Sbjct: 798 QLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFD 857

Query: 505 --GTNVNQLN-------------------YRSHMELKTSDHKPVSALFHIGVKVVDERRY 543
               +++ LN                   +    ELKTSDH+PV AL  I +  V+    
Sbjct: 858 RSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEER 917

Query: 544 RKVFEDSVRIMDRMENDFLPSLELSRRE 571
           + ++++ + +    +   L S++ S  E
Sbjct: 918 QNIYKEVIAVQGPPDGTVLVSIKSSLPE 945


>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
          Length = 1526

 Score =  206 bits (524), Expect = 8e-53
 Identities = 125/388 (32%), Positives = 194/388 (50%), Gaps = 56/388 (14%)

Query: 233 EYVNIQTFRFFVGTWNVNGQSP-------DSGLEPWLNCDPN-------------PPDIY 272
           +Y   +  R  VGTWNVNG          +  L  WL   P              P DI+
Sbjct: 521 KYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIF 580

Query: 273 CIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLIFARKD 331
            IGF+E+ +L+        +  ++ W++ +++ +    KY  +   +LVG+ L +F R  
Sbjct: 581 AIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQ 640

Query: 332 QCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQDYK 391
              +IRD+A +TV TG+ G  GNKG VA+R +FH T+ C V SH AA     + RN+D+ 
Sbjct: 641 HAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFI 700

Query: 392 DICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQRLLKFD 451
           +I  ++SF +         +  H+ V W GD NYR+ +P+  EVK LI +++   L+  D
Sbjct: 701 EIARKLSFPMGRM------LFSHDYVFWCGDFNYRIDLPN-EEVKELIRQQNWDSLIAGD 753

Query: 452 QLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWR------- 504
           QL  Q+   + F  F EG++ F PTYKYD  +D +D+S KCR PAW DR+LWR       
Sbjct: 754 QLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFD 813

Query: 505 --GTNVNQLN-------------------YRSHMELKTSDHKPVSALFHIGVKVVDERRY 543
               +++ LN                   +    ELKTSDH+PV AL  I +  V+    
Sbjct: 814 RSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEER 873

Query: 544 RKVFEDSVRIMDRMENDFLPSLELSRRE 571
           + ++++ + +    +   L S++ S  E
Sbjct: 874 QNIYKEVIAVQGPPDGTVLVSIKSSLPE 901


>gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatase,
           A [Homo sapiens]
          Length = 638

 Score =  174 bits (440), Expect = 4e-43
 Identities = 106/311 (34%), Positives = 157/311 (50%), Gaps = 26/311 (8%)

Query: 241 RFFVGTWNVNGQSPDSGLEPWLNC----DPNPPDIYCIGFQELDLSTEAFFYFESVKEQE 296
           R  V TWNV    P   +   L+     D +  D+  IG QE++         +++   +
Sbjct: 56  RITVVTWNVGTAMPPDDVTSLLHLGGGDDSDGADMIAIGLQEVNSMLNKRLK-DALFTDQ 114

Query: 297 WSMAVERGLHSKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKG 356
           WS      L     +  V  VR+ G++LL+FA+     ++RD+ T+   TG+ G  GNKG
Sbjct: 115 WSELFMDAL-GPFNFVLVSSVRMQGVILLLFAKYYHLPFLRDVQTDCTRTGLGGYWGNKG 173

Query: 357 GVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEV 416
           GV+VR        C +N HL AH++  E+R  +++ I +   F  P        I+ H++
Sbjct: 174 GVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGAQ----GILDHDL 229

Query: 417 VIWLGDLNYRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPT 476
           V W GDLN+R+   D + VK  I+   L +L + DQLN+ +        F EG + F PT
Sbjct: 230 VFWFGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILKGFQEGPLNFAPT 289

Query: 477 YKYDSKTDRWDSSGKCRVPAWCDRILWR----------------GTNVNQLNYRSHMELK 520
           +K+D  T+++D+S K R PAW DRILW+                   V Q +YRSHME  
Sbjct: 290 FKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKSHRLQVTQHSYRSHMEYT 349

Query: 521 TSDHKPVSALF 531
            SDHKPV+A F
Sbjct: 350 VSDHKPVAAQF 360


>gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo
           sapiens]
          Length = 1258

 Score =  167 bits (423), Expect = 4e-41
 Identities = 106/317 (33%), Positives = 162/317 (51%), Gaps = 38/317 (11%)

Query: 243 FVGTWNVNGQSPDSGLEPWLNCD-----------PNPPDIYCIGFQELDLSTEAFFYFES 291
           F+GTWN+    P   +  W                 P DIY  G QE            S
Sbjct: 427 FIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQE-----------NS 475

Query: 292 VKEQEWSMAVERGLH--SKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIM 349
           V ++EW   +  GL   +   Y+ + +  L  + + +  + +    I  ++T +V TGI 
Sbjct: 476 VGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIA 535

Query: 350 GKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQL 409
             +GNKG V V F+F+ T+F  VN HL +  E   RRNQ+Y DI   +S  + ++ L   
Sbjct: 536 NTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLS--LGDRQLNAF 593

Query: 410 NI-MKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNE 468
           +I ++   + W GDLNYRL M D  E+ + I++K+ + LL+ DQLN++R + K F+ F+E
Sbjct: 594 DISLRFTHLFWFGDLNYRLDM-DIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSE 652

Query: 469 GEIKFIPTYKYD---SKTDRW----DSSGKCRVPAWCDRILWRG---TNVNQLNYRSHME 518
            EI F PTY+Y+     T  W     +  +  VP+WCDRILW+    T++   +Y    +
Sbjct: 653 EEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDD 712

Query: 519 LKTSDHKPVSALFHIGV 535
           + TSDH PV   F +GV
Sbjct: 713 IVTSDHSPVFGTFEVGV 729


>gi|40254823 SH2 containing inositol phosphatase isoform b [Homo
           sapiens]
          Length = 1188

 Score =  162 bits (410), Expect = 1e-39
 Identities = 114/358 (31%), Positives = 175/358 (48%), Gaps = 42/358 (11%)

Query: 206 MRKLFVPNTQSGQREGLIKHILAKREK--EYVNIQTFRFFVGTWNVNGQSPDSGLEPWL- 262
           +RK +V    S +REG  + +   + K  E         F+GTWN+    P   +  W  
Sbjct: 368 LRKEYV-FADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFL 426

Query: 263 ----------NCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMAVERGLH--SKAK 310
                     + D  P DIY IG QE  LS           E+EW   ++  L   +   
Sbjct: 427 SKGQGKTRDDSADYIPHDIYVIGTQEDPLS-----------EKEWLEILKHSLQEITSVT 475

Query: 311 YKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFC 370
           +K V +  L  + +++ A+ +    I  I T+ V TGI   +GNKG V V F+F+ T+  
Sbjct: 476 FKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLG 535

Query: 371 IVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIM-KHEVVIWLGDLNYRLCM 429
            VNSHL +  E   RRNQ+Y +I   ++  + ++ L   NI  +   + W GDLNYR+ +
Sbjct: 536 FVNSHLTSGSEKKLRRNQNYMNILRFLA--LGDKKLSPFNITHRFTHLFWFGDLNYRVDL 593

Query: 430 P--DANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYD------- 480
           P  +A  +   I ++    LL  DQL  +R ++K F+ F E EI F PTY+++       
Sbjct: 594 PTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKY 653

Query: 481 SKTDRWDSSGKCRVPAWCDRILWRG---TNVNQLNYRSHMELKTSDHKPVSALFHIGV 535
           + T +  +  K  +P+WCDR+LW+     +V   +Y S  ++ TSDH PV A F  GV
Sbjct: 654 AYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGV 711


>gi|64085167 SH2 containing inositol phosphatase isoform a [Homo
           sapiens]
          Length = 1189

 Score =  162 bits (410), Expect = 1e-39
 Identities = 114/358 (31%), Positives = 175/358 (48%), Gaps = 42/358 (11%)

Query: 206 MRKLFVPNTQSGQREGLIKHILAKREK--EYVNIQTFRFFVGTWNVNGQSPDSGLEPWL- 262
           +RK +V    S +REG  + +   + K  E         F+GTWN+    P   +  W  
Sbjct: 369 LRKEYV-FADSKKREGFCQLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFL 427

Query: 263 ----------NCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWSMAVERGLH--SKAK 310
                     + D  P DIY IG QE  LS           E+EW   ++  L   +   
Sbjct: 428 SKGQGKTRDDSADYIPHDIYVIGTQEDPLS-----------EKEWLEILKHSLQEITSVT 476

Query: 311 YKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFC 370
           +K V +  L  + +++ A+ +    I  I T+ V TGI   +GNKG V V F+F+ T+  
Sbjct: 477 FKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLG 536

Query: 371 IVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIM-KHEVVIWLGDLNYRLCM 429
            VNSHL +  E   RRNQ+Y +I   ++  + ++ L   NI  +   + W GDLNYR+ +
Sbjct: 537 FVNSHLTSGSEKKLRRNQNYMNILRFLA--LGDKKLSPFNITHRFTHLFWFGDLNYRVDL 594

Query: 430 P--DANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYD------- 480
           P  +A  +   I ++    LL  DQL  +R ++K F+ F E EI F PTY+++       
Sbjct: 595 PTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKY 654

Query: 481 SKTDRWDSSGKCRVPAWCDRILWRG---TNVNQLNYRSHMELKTSDHKPVSALFHIGV 535
           + T +  +  K  +P+WCDR+LW+     +V   +Y S  ++ TSDH PV A F  GV
Sbjct: 655 AYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGV 712


>gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Homo
           sapiens]
          Length = 448

 Score =  151 bits (381), Expect = 3e-36
 Identities = 100/312 (32%), Positives = 155/312 (49%), Gaps = 25/312 (8%)

Query: 244 VGTWNVNGQSPDSGLEPWLNCDPNPP--DIYCIGFQELDLSTEAFFYFESVKEQEWSMAV 301
           V TWNV   +P   L   L  +      DIY IG QEL+    +    ++     WS  +
Sbjct: 18  VVTWNVASAAPPLDLSDLLQLNNRNLNLDIYVIGLQELNSGIISLLS-DAAFNDSWSSFL 76

Query: 302 ERGLHSKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVR 361
              L S   + KV  VR+ G++LL+FA+     YI+ ++T++  TG+ G  GNKGGV + 
Sbjct: 77  MDVL-SPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNIC 135

Query: 362 FVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLG 421
              +     I+N HL  H+ +  +R + +  I    +     + +P  NI+ H+++IW G
Sbjct: 136 LKLYGYYVSIINCHLPPHISNNYQRLEHFDRILEMQN--CEGRDIP--NILDHDLIIWFG 191

Query: 422 DLNYRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDS 481
           D+N+R+     + V+  I  +    L + DQL+I +       +F EG + F PTYK+D 
Sbjct: 192 DMNFRIEDFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDR 251

Query: 482 KTDRWDSSGKCRVPAWCDRILWR-----------------GTNVNQLNYRSHMELKTSDH 524
            ++ +D+S K R PAW DRILWR                   +++   Y SHM    SDH
Sbjct: 252 NSNDYDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDH 311

Query: 525 KPVSALFHIGVK 536
           KPVS  F + +K
Sbjct: 312 KPVSGTFDLELK 323


>gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
           sapiens]
          Length = 372

 Score =  138 bits (348), Expect = 2e-32
 Identities = 81/247 (32%), Positives = 129/247 (52%), Gaps = 21/247 (8%)

Query: 307 SKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHN 366
           S   + KV  VR+ G++LL+FA+     YI+ ++T++  TG+ G  GNKGGV +    + 
Sbjct: 5   SPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYG 64

Query: 367 TTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYR 426
               I+N HL  H+ +  +R + +  I    +     + +P  NI+ H+++IW GD+N+R
Sbjct: 65  YYVSIINCHLPPHISNNYQRLEHFDRILEMQN--CEGRDIP--NILDHDLIIWFGDMNFR 120

Query: 427 LCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRW 486
           +     + V+  I  +    L + DQL+I +       +F EG + F PTYK+D  ++ +
Sbjct: 121 IEDFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDY 180

Query: 487 DSSGKCRVPAWCDRILWR-----------------GTNVNQLNYRSHMELKTSDHKPVSA 529
           D+S K R PAW DRILWR                   +++   Y SHM    SDHKPVS 
Sbjct: 181 DTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSG 240

Query: 530 LFHIGVK 536
            F + +K
Sbjct: 241 TFDLELK 247


>gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
           sapiens]
          Length = 372

 Score =  138 bits (348), Expect = 2e-32
 Identities = 81/247 (32%), Positives = 129/247 (52%), Gaps = 21/247 (8%)

Query: 307 SKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHN 366
           S   + KV  VR+ G++LL+FA+     YI+ ++T++  TG+ G  GNKGGV +    + 
Sbjct: 5   SPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYG 64

Query: 367 TTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYR 426
               I+N HL  H+ +  +R + +  I    +     + +P  NI+ H+++IW GD+N+R
Sbjct: 65  YYVSIINCHLPPHISNNYQRLEHFDRILEMQN--CEGRDIP--NILDHDLIIWFGDMNFR 120

Query: 427 LCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRW 486
           +     + V+  I  +    L + DQL+I +       +F EG + F PTYK+D  ++ +
Sbjct: 121 IEDFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDY 180

Query: 487 DSSGKCRVPAWCDRILWR-----------------GTNVNQLNYRSHMELKTSDHKPVSA 529
           D+S K R PAW DRILWR                   +++   Y SHM    SDHKPVS 
Sbjct: 181 DTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGISDHKPVSG 240

Query: 530 LFHIGVK 536
            F + +K
Sbjct: 241 TFDLELK 247


>gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens]
          Length = 644

 Score =  115 bits (287), Expect = 2e-25
 Identities = 90/313 (28%), Positives = 145/313 (46%), Gaps = 37/313 (11%)

Query: 243 FVGTWNVNGQS--PDSGLEPWLNCDPN-PPDIYCIGFQELDLSTEAFFYFESVKEQEWSM 299
           FV TWN+ GQ   P S  E  L  + +   D+Y IG QE                +EW  
Sbjct: 302 FVATWNMQGQKELPPSLDEFLLPAEADYAQDLYVIGVQE-----------GCSDRREWET 350

Query: 300 AVERGLHSKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIMGKMGNKGGVA 359
            ++  L     Y  +       + + +F R+D   +  ++   TV T I+ ++  KG + 
Sbjct: 351 RLQETLGPH--YVLLSSAAHGVLYMSLFIRRDLIWFCSEVECSTVTTRIVSQIKTKGALG 408

Query: 360 VRFVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQLN--------- 410
           + F F  T+F  + SH  +       R  DY       + V+P + +P  N         
Sbjct: 409 ISFTFFGTSFLFITSHFTSGDGKVAERLLDYTRTV--QALVLP-RNVPDTNPYRSSAADV 465

Query: 411 IMKHEVVIWLGDLNYRLC----MPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDF 466
             + + V W GD N+RL     + DA   + L+   D+  LL+ DQL  +  +   F  F
Sbjct: 466 TTRFDEVFWFGDFNFRLSGGRTVVDALLCQGLV--VDVPALLQHDQLIREMRKGSIFKGF 523

Query: 467 NEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWRGT---NVNQLNYRSHMELKTSD 523
            E +I F+P+YK+D   D +DS+ K R P++ DR+L+R     ++  ++Y S   +KTSD
Sbjct: 524 QEPDIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYRSRHKGDICPVSYSSCPGIKTSD 583

Query: 524 HKPVSALFHIGVK 536
           H+PV  LF + V+
Sbjct: 584 HRPVYGLFRVKVR 596


>gi|56119110 family with sequence similarity 13, member A1 isoform a
           [Homo sapiens]
          Length = 1023

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 56/208 (26%), Positives = 92/208 (44%), Gaps = 23/208 (11%)

Query: 681 GTSLEALCRMKRPIR---------EVPVTKLIDLEKSLLQMVPLDE----GASERPLQVP 727
           G    A+C+ K  +R          VP+ +  D     L  V L E    G +E    +P
Sbjct: 2   GAGALAICQSKAAVRLKEDMKKIVAVPLNEQKDFTYQKLFGVSLQELERQGLTENG--IP 59

Query: 728 KEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETI--PGSNHSVAEALLI 785
             +W +V++L ++   QE LF+  G  + ++Q+    ++ +P  +   G   S A  L +
Sbjct: 60  AVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKDGDVCSAASLLKL 119

Query: 786 FLEALPEPVICYELYQRCLDSAYDPR------ICRQVISQLPRCHRNVFRYLMAFLRELL 839
           FL  LP+ +I   L  R +    D R        R +I +LP  H  + +YL  FL ++ 
Sbjct: 120 FLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHYCLLKYLCQFLTKVA 179

Query: 840 KFSEYNSVNANMIATLFTSLLLRPPPNL 867
           K    N +N + +AT+F       PP L
Sbjct: 180 KHHVQNRMNVHNLATVFGPNCFHVPPGL 207


>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
          Length = 698

 Score = 63.5 bits (153), Expect = 8e-10
 Identities = 45/153 (29%), Positives = 75/153 (49%), Gaps = 14/153 (9%)

Query: 723 PLQVPKEIWLLVDHLFKYACHQEDLFQTPG---MQEELQQIIDCLDTSIPETIPGSNHSV 779
           P   P  +   VD + +    +E LF+ PG   +  +LQ   DC +  + ++     H+V
Sbjct: 169 PRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDV-HTV 227

Query: 780 AEALLIFLEALPEPVICYELYQRCLDSAY---------DPRICRQVISQLPRCHRNVFRY 830
           A  L ++L  LPEPV+ +  Y+  L  A             + +QV S LP+ + N+ RY
Sbjct: 228 ASLLKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQV-SNLPQANYNLLRY 286

Query: 831 LMAFLRELLKFSEYNSVNANMIATLFTSLLLRP 863
           +  FL E+  +S  N ++   +AT+F   +LRP
Sbjct: 287 ICKFLDEVQAYSNVNKMSVQNLATVFGPNILRP 319


>gi|111154090 Rho GTPase activating protein 24 isoform 3 [Homo
           sapiens]
          Length = 653

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 42/141 (29%), Positives = 70/141 (49%), Gaps = 12/141 (8%)

Query: 734 VDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSN--HSVAEALLIFLEALP 791
           VD + +    +E LF+ PG    ++++ D  D     +   +   H+VA  L ++L  LP
Sbjct: 65  VDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELP 124

Query: 792 EPVICYELYQRCL---------DSAYDPRICRQVISQLPRCHRNVFRYLMAFLRELLKFS 842
           EPVI Y  Y+  L         + A    + +QV S LP  + N+ +Y+  FL E+  +S
Sbjct: 125 EPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKS-LPVVNYNLLKYICRFLDEVQSYS 183

Query: 843 EYNSVNANMIATLFTSLLLRP 863
             N ++   +AT+F   +LRP
Sbjct: 184 GVNKMSVQNLATVFGPNILRP 204


>gi|111154099 Rho GTPase activating protein 24 isoform 2 [Homo
           sapiens]
          Length = 655

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 42/141 (29%), Positives = 70/141 (49%), Gaps = 12/141 (8%)

Query: 734 VDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSN--HSVAEALLIFLEALP 791
           VD + +    +E LF+ PG    ++++ D  D     +   +   H+VA  L ++L  LP
Sbjct: 67  VDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELP 126

Query: 792 EPVICYELYQRCL---------DSAYDPRICRQVISQLPRCHRNVFRYLMAFLRELLKFS 842
           EPVI Y  Y+  L         + A    + +QV S LP  + N+ +Y+  FL E+  +S
Sbjct: 127 EPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKS-LPVVNYNLLKYICRFLDEVQSYS 185

Query: 843 EYNSVNANMIATLFTSLLLRP 863
             N ++   +AT+F   +LRP
Sbjct: 186 GVNKMSVQNLATVFGPNILRP 206


>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
           sapiens]
          Length = 748

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 42/141 (29%), Positives = 70/141 (49%), Gaps = 12/141 (8%)

Query: 734 VDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSN--HSVAEALLIFLEALP 791
           VD + +    +E LF+ PG    ++++ D  D     +   +   H+VA  L ++L  LP
Sbjct: 160 VDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELP 219

Query: 792 EPVICYELYQRCL---------DSAYDPRICRQVISQLPRCHRNVFRYLMAFLRELLKFS 842
           EPVI Y  Y+  L         + A    + +QV S LP  + N+ +Y+  FL E+  +S
Sbjct: 220 EPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKS-LPVVNYNLLKYICRFLDEVQSYS 278

Query: 843 EYNSVNANMIATLFTSLLLRP 863
             N ++   +AT+F   +LRP
Sbjct: 279 GVNKMSVQNLATVFGPNILRP 299


>gi|226423858 PRR5-ARHGAP8 fusion protein [Homo sapiens]
          Length = 555

 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 39/145 (26%), Positives = 71/145 (48%), Gaps = 7/145 (4%)

Query: 726 VPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIP--GSNHSVAEAL 783
           +P  +   V +L +     E LF+     + +++I    +   P      G  H  A  L
Sbjct: 331 IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVIL 390

Query: 784 LIFLEALPEPVICYELYQR-----CLDSAYDPRICRQVISQLPRCHRNVFRYLMAFLREL 838
             FL  LP+P++ ++ Y++     C++S+     CRQ++  LP  +  V RYLM FL  +
Sbjct: 391 KTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAV 450

Query: 839 LKFSEYNSVNANMIATLFTSLLLRP 863
            + S +N +N++ +A +F   L+ P
Sbjct: 451 SRESIFNKMNSSNLACVFGLNLIWP 475


>gi|66346660 Rho GTPase activating protein 8 isoform 2 [Homo
           sapiens]
          Length = 433

 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 39/145 (26%), Positives = 71/145 (48%), Gaps = 7/145 (4%)

Query: 726 VPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIP--GSNHSVAEAL 783
           +P  +   V +L +     E LF+     + +++I    +   P      G  H  A  L
Sbjct: 209 IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVIL 268

Query: 784 LIFLEALPEPVICYELYQR-----CLDSAYDPRICRQVISQLPRCHRNVFRYLMAFLREL 838
             FL  LP+P++ ++ Y++     C++S+     CRQ++  LP  +  V RYLM FL  +
Sbjct: 269 KTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAV 328

Query: 839 LKFSEYNSVNANMIATLFTSLLLRP 863
            + S +N +N++ +A +F   L+ P
Sbjct: 329 SRESIFNKMNSSNLACVFGLNLIWP 353


>gi|66346662 Rho GTPase activating protein 8 isoform 1 [Homo
           sapiens]
          Length = 464

 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 39/145 (26%), Positives = 71/145 (48%), Gaps = 7/145 (4%)

Query: 726 VPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIP--GSNHSVAEAL 783
           +P  +   V +L +     E LF+     + +++I    +   P      G  H  A  L
Sbjct: 240 IPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVIL 299

Query: 784 LIFLEALPEPVICYELYQR-----CLDSAYDPRICRQVISQLPRCHRNVFRYLMAFLREL 838
             FL  LP+P++ ++ Y++     C++S+     CRQ++  LP  +  V RYLM FL  +
Sbjct: 300 KTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAV 359

Query: 839 LKFSEYNSVNANMIATLFTSLLLRP 863
            + S +N +N++ +A +F   L+ P
Sbjct: 360 SRESIFNKMNSSNLACVFGLNLIWP 384


>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
          Length = 468

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 38/151 (25%), Positives = 67/151 (44%), Gaps = 11/151 (7%)

Query: 725 QVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLD-----TSIPETIPGSNHSV 779
           Q P  + + +  +       E L++  G  E ++ +    D       I   +    + +
Sbjct: 289 QRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINII 348

Query: 780 AEALLIFLEALPEPVICYELYQRCLDSAY----DPRI--CRQVISQLPRCHRNVFRYLMA 833
             AL ++   LP PVI Y+ Y + +D+A     D R+    +V+  LP  H    RYLM 
Sbjct: 349 TGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMI 408

Query: 834 FLRELLKFSEYNSVNANMIATLFTSLLLRPP 864
            L+++    + N +NA  +  +F   L+RPP
Sbjct: 409 HLKKVTMNEKDNFMNAENLGIVFGPTLMRPP 439


>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
          Length = 332

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 38/151 (25%), Positives = 67/151 (44%), Gaps = 11/151 (7%)

Query: 725 QVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLD-----TSIPETIPGSNHSV 779
           Q P  + + +  +       E L++  G  E ++ +    D       I   +    + +
Sbjct: 153 QRPMVVDICIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISANVYPDINII 212

Query: 780 AEALLIFLEALPEPVICYELYQRCLDSAY----DPRI--CRQVISQLPRCHRNVFRYLMA 833
             AL ++   LP PVI Y+ Y + +D+A     D R+    +V+  LP  H    RYLM 
Sbjct: 213 TGALKLYFRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMI 272

Query: 834 FLRELLKFSEYNSVNANMIATLFTSLLLRPP 864
            L+++    + N +NA  +  +F   L+RPP
Sbjct: 273 HLKKVTMNEKDNFMNAENLGIVFGPTLMRPP 303


>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
          Length = 818

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 40/159 (25%), Positives = 76/159 (47%), Gaps = 10/159 (6%)

Query: 714 PLDEGASERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQI---IDCLDTSIPE 770
           PL+E  +    ++   I   V  L +    +E LF+      +L+++   +DC    + E
Sbjct: 256 PLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQE 315

Query: 771 TIPGSNHSVAEALLIFLEALPEPVICYELYQRCLDSA----YDPRI--CRQVISQLPRCH 824
                 H++A AL  +L  LPEP++ +ELY   + ++     D ++        +LP+ +
Sbjct: 316 -YSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKAN 374

Query: 825 RNVFRYLMAFLRELLKFSEYNSVNANMIATLFTSLLLRP 863
            N  RYL+ FL +L ++ + N +  + +A +    LL P
Sbjct: 375 HNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWP 413


>gi|55770898 Rho GTPase activating protein 25 isoform a [Homo
           sapiens]
          Length = 645

 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 41/164 (25%), Positives = 76/164 (46%), Gaps = 13/164 (7%)

Query: 723 PLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSN--HSVA 780
           P  VP  +    + + ++  ++E +F+ PG    ++Q+ D  D     +       H+VA
Sbjct: 173 PHLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVA 232

Query: 781 EALLIFLEALPEPVICYELYQRCL--------DSAYDPRICRQVISQLPRCHRNVFRYLM 832
             L ++L  LPEPV+ +  Y+  L        D A   +   + +S LPR + ++  Y+ 
Sbjct: 233 SLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYIC 292

Query: 833 AFLRELLKFSEYNSVNANMIATLFTSLLLR---PPPNLMARQTP 873
            FL E+      N ++ + +AT+    L+R     P ++ R TP
Sbjct: 293 RFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTP 336


>gi|7661882 Rho GTPase activating protein 25 isoform b [Homo
           sapiens]
          Length = 638

 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 41/164 (25%), Positives = 76/164 (46%), Gaps = 13/164 (7%)

Query: 723 PLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSN--HSVA 780
           P  VP  +    + + ++  ++E +F+ PG    ++Q+ D  D     +       H+VA
Sbjct: 166 PHLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVA 225

Query: 781 EALLIFLEALPEPVICYELYQRCL--------DSAYDPRICRQVISQLPRCHRNVFRYLM 832
             L ++L  LPEPV+ +  Y+  L        D A   +   + +S LPR + ++  Y+ 
Sbjct: 226 SLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYIC 285

Query: 833 AFLRELLKFSEYNSVNANMIATLFTSLLLR---PPPNLMARQTP 873
            FL E+      N ++ + +AT+    L+R     P ++ R TP
Sbjct: 286 RFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTP 329


>gi|134304853 PTPL1-associated RhoGAP 1 [Homo sapiens]
          Length = 1261

 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 39/205 (19%), Positives = 89/205 (43%), Gaps = 37/205 (18%)

Query: 719 ASERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIIDCLDTS--IPETIPGSN 776
           A + P  +P  + +    +   A   + +++  G + + +++   L+    + +    S+
Sbjct: 677 AKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSS 736

Query: 777 HSVAEALLIFLEALPEPVICYELYQRCLDSAYD--------------------PRIC--- 813
           H + + L ++L  LPEP I + LY+  +D A +                    P +C   
Sbjct: 737 HDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEI 796

Query: 814 -------RQVISQLPRCHRNVFRYLMAFLRELLKFSEYNSVNANMIATLFTSLLLRPPP- 865
                  + ++ QLP  + N   +L+  L+ ++  +E N +N+  +  +F   L+RP P 
Sbjct: 797 NRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPT 856

Query: 866 ----NLMARQTPSDRQRAIQFLLGF 886
                + +    S++ R ++FL+ +
Sbjct: 857 TAPITISSLAEYSNQARLVEFLITY 881


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.415 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,755,200
Number of Sequences: 37866
Number of extensions: 1681208
Number of successful extensions: 4678
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 4480
Number of HSP's gapped (non-prelim): 152
length of query: 893
length of database: 18,247,518
effective HSP length: 111
effective length of query: 782
effective length of database: 14,044,392
effective search space: 10982714544
effective search space used: 10982714544
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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