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Search of human proteins with 48255881
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens]
(285 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens] 560 e-160
gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens] 554 e-158
gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens] 551 e-157
gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens] 540 e-154
gi|187173290 troponin T1, skeletal, slow isoform b [Homo sapiens] 323 8e-89
gi|187173292 troponin T1, skeletal, slow isoform c [Homo sapiens] 318 3e-87
gi|187173288 troponin T1, skeletal, slow isoform a [Homo sapiens] 313 1e-85
gi|5803203 troponin T3, skeletal, fast isoform 1 [Homo sapiens] 306 2e-83
gi|112789541 troponin T3, skeletal, fast isoform 4 [Homo sapiens] 300 7e-82
gi|112789538 troponin T3, skeletal, fast isoform 2 [Homo sapiens] 300 1e-81
gi|112789536 troponin T3, skeletal, fast isoform 3 [Homo sapiens] 292 2e-79
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 74 2e-13
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 73 2e-13
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 73 2e-13
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 73 3e-13
gi|148746195 trichohyalin [Homo sapiens] 73 3e-13
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 72 4e-13
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 72 6e-13
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 72 7e-13
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 71 9e-13
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 71 1e-12
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 71 1e-12
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 70 2e-12
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 70 2e-12
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 70 2e-12
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 70 2e-12
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 70 2e-12
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 70 2e-12
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 70 2e-12
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 70 2e-12
>gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens]
Length = 285
Score = 560 bits (1442), Expect = e-160
Identities = 285/285 (100%), Positives = 285/285 (100%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM
Sbjct: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
Query: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL
Sbjct: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
Query: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN
Sbjct: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
Query: 181 MMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNL 240
MMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNL
Sbjct: 181 MMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNL 240
Query: 241 EAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 285
EAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
Sbjct: 241 EAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 285
>gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens]
Length = 288
Score = 554 bits (1428), Expect = e-158
Identities = 285/288 (98%), Positives = 285/288 (98%), Gaps = 3/288 (1%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM
Sbjct: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
Query: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL
Sbjct: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
Query: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN
Sbjct: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
Query: 181 MMHFGGYIQK---TERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI 237
MMHFGGYIQK TERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI
Sbjct: 181 MMHFGGYIQKQAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI 240
Query: 238 YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 285
YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
Sbjct: 241 YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 288
>gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens]
Length = 295
Score = 551 bits (1421), Expect = e-157
Identities = 285/295 (96%), Positives = 285/295 (96%), Gaps = 10/295 (3%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEE----------QEEAAEEDAEAEAETEETRAEEDEEEE 50
MSDIEEVVEEYEEEEQEEAAVEE QEEAAEEDAEAEAETEETRAEEDEEEE
Sbjct: 1 MSDIEEVVEEYEEEEQEEAAVEEEEDWREDEDEQEEAAEEDAEAEAETEETRAEEDEEEE 60
Query: 51 EAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF 110
EAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF
Sbjct: 61 EAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF 120
Query: 111 ENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAED 170
ENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAED
Sbjct: 121 ENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAED 180
Query: 171 EARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKA 230
EARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKA
Sbjct: 181 EARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKA 240
Query: 231 KELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 285
KELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
Sbjct: 241 KELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 295
>gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens]
Length = 282
Score = 540 bits (1391), Expect = e-154
Identities = 280/287 (97%), Positives = 280/287 (97%), Gaps = 7/287 (2%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
MSDIEEVVEEYEEEEQEE QEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM
Sbjct: 1 MSDIEEVVEEYEEEEQEE-----QEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 55
Query: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL
Sbjct: 56 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 115
Query: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN
Sbjct: 116 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 175
Query: 181 MMHFGGYIQK--TERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIY 238
MMHFGGYIQK TERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIY
Sbjct: 176 MMHFGGYIQKAQTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIY 235
Query: 239 NLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 285
NLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK
Sbjct: 236 NLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 282
>gi|187173290 troponin T1, skeletal, slow isoform b [Homo sapiens]
Length = 262
Score = 323 bits (829), Expect = 8e-89
Identities = 178/287 (62%), Positives = 211/287 (73%), Gaps = 27/287 (9%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
MSD EE +EYEEE+ EE A EE+EEA EE E AE EE R
Sbjct: 1 MSDTEE--QEYEEEQPEEEAAEEEEEAPEE-PEPVAEPEEER------------------ 39
Query: 61 EESKPKP-RSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE 119
PKP R +P L+PPKIP+GERVDFDDIHRKRMEKDL ELQ LI+ HFE RKKEEEE
Sbjct: 40 ----PKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEE 95
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALS 179
LV+LK+RIERRR+ERAEQQR R E+E+ERQ +LAEE+ R+EEEE +++AED+A+KKK LS
Sbjct: 96 LVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLS 155
Query: 180 NM-MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIY 238
NM HFGGY+ K E+K GKRQT RE K +IL+ER+K L ID++ E+QLREKA+EL I+
Sbjct: 156 NMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLREKAQELSDWIH 215
Query: 239 NLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 285
LE+EKFDL K KQQKYEINVL NRI+ QK K GK +V GRWK
Sbjct: 216 QLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGGRWK 262
>gi|187173292 troponin T1, skeletal, slow isoform c [Homo sapiens]
Length = 251
Score = 318 bits (816), Expect = 3e-87
Identities = 165/252 (65%), Positives = 201/252 (79%), Gaps = 4/252 (1%)
Query: 36 AETEETRAEEDEEEEEAKEAEDGPMEESKPKP-RSFMPNLVPPKIPDGERVDFDDIHRKR 94
++TEE EE++ EEEA E E+ EE +PKP R +P L+PPKIP+GERVDFDDIHRKR
Sbjct: 2 SDTEEQEYEEEQPEEEAAEEEEE--EEERPKPSRPVVPPLIPPKIPEGERVDFDDIHRKR 59
Query: 95 MEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE 154
MEKDL ELQ LI+ HFE RKKEEEELV+LK+RIERRR+ERAEQQR R E+E+ERQ +LAE
Sbjct: 60 MEKDLLELQTLIDVHFEQRKKEEEELVALKERIERRRSERAEQQRFRTEKERERQAKLAE 119
Query: 155 ERARREEEENRRKAEDEARKKKALSNM-MHFGGYIQKTERKSGKRQTEREKKKKILAERR 213
E+ R+EEEE +++AED+A+KKK LSNM HFGGY+ K E+K GKRQT RE K +IL+ER+
Sbjct: 120 EKMRKEEEEAKKRAEDDAKKKKVLSNMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERK 179
Query: 214 KVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSK 273
K L ID++ E+QLREKA+EL I+ LE+EKFDL K KQQKYEINVL NRI+ QK K
Sbjct: 180 KPLDIDYMGEEQLREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRK 239
Query: 274 TRGKAKVTGRWK 285
GK +V GRWK
Sbjct: 240 GAGKGRVGGRWK 251
>gi|187173288 troponin T1, skeletal, slow isoform a [Homo sapiens]
Length = 278
Score = 313 bits (802), Expect = 1e-85
Identities = 178/303 (58%), Positives = 211/303 (69%), Gaps = 43/303 (14%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPM 60
MSD EE +EYEEE+ EE A EE+EEA EE E AE EE R
Sbjct: 1 MSDTEE--QEYEEEQPEEEAAEEEEEAPEE-PEPVAEPEEER------------------ 39
Query: 61 EESKPKP-RSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE 119
PKP R +P L+PPKIP+GERVDFDDIHRKRMEKDL ELQ LI+ HFE RKKEEEE
Sbjct: 40 ----PKPSRPVVPPLIPPKIPEGERVDFDDIHRKRMEKDLLELQTLIDVHFEQRKKEEEE 95
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALS 179
LV+LK+RIERRR+ERAEQQR R E+E+ERQ +LAEE+ R+EEEE +++AED+A+KKK LS
Sbjct: 96 LVALKERIERRRSERAEQQRFRTEKERERQAKLAEEKMRKEEEEAKKRAEDDAKKKKVLS 155
Query: 180 NM-MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQL------------ 226
NM HFGGY+ K E+K GKRQT RE K +IL+ER+K L ID++ E+QL
Sbjct: 156 NMGAHFGGYLVKAEQKRGKRQTGREMKVRILSERKKPLDIDYMGEEQLRARSAWLPPSQP 215
Query: 227 ----REKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTG 282
REKA+EL I+ LE+EKFDL K KQQKYEINVL NRI+ QK K GK +V G
Sbjct: 216 SCPAREKAQELSDWIHQLESEKFDLMAKLKQQKYEINVLYNRISHAQKFRKGAGKGRVGG 275
Query: 283 RWK 285
RWK
Sbjct: 276 RWK 278
>gi|5803203 troponin T3, skeletal, fast isoform 1 [Homo sapiens]
Length = 258
Score = 306 bits (783), Expect = 2e-83
Identities = 166/278 (59%), Positives = 206/278 (74%), Gaps = 27/278 (9%)
Query: 12 EEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFM 71
EE EQ E EE+EEA EE+ E +E AEED EEE KP+P+
Sbjct: 4 EEVEQVEEQYEEEEEAQEEE-----EVQEDTAEEDAEEE-------------KPRPK--- 42
Query: 72 PNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRR 131
L PKIP+GE+VDFDDI +KR KDL ELQALI++HFE RKKEEEELV+LK+RIE+RR
Sbjct: 43 --LTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRR 100
Query: 132 AERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNM-MHFGGYIQK 190
AERAEQQRIR E+E+ERQNRLAEE+ARREEE+ +R+AED+ +KKKALS+M ++ Y+ K
Sbjct: 101 AERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAK 160
Query: 191 TERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEK 250
++K GK+QT RE KKKILAERRK L IDHL ED+LR+KAKELW++++ LE +KF+ EK
Sbjct: 161 ADQKRGKKQTAREMKKKILAERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEK 220
Query: 251 FKQQKYEINVLRNRINDNQKVSKTRG---KAKVTGRWK 285
K+QKY+I LR+RI+ QK SK G K KV GRWK
Sbjct: 221 LKRQKYDITTLRSRIDQAQKHSKKAGTPAKGKVGGRWK 258
>gi|112789541 troponin T3, skeletal, fast isoform 4 [Homo sapiens]
Length = 250
Score = 300 bits (769), Expect = 7e-82
Identities = 155/254 (61%), Positives = 197/254 (77%), Gaps = 9/254 (3%)
Query: 36 AETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRM 95
++ E + EE EEEE + E+ EE KP+P+ L PKIP+GE+VDFDDI +KR
Sbjct: 2 SDEEVEQVEEQYEEEEEAQEEEEVQEEEKPRPK-----LTAPKIPEGEKVDFDDIQKKRQ 56
Query: 96 EKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEE 155
KDL ELQALI++HFE RKKEEEELV+LK+RIE+RRAERAEQQRIR E+E+ERQNRLAEE
Sbjct: 57 NKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEE 116
Query: 156 RARREEEENRRKAEDEARKKKALSNM-MHFGGYIQKTERKSGKRQTEREKKKKILAERRK 214
+ARREEE+ +R+AED+ +KKKALS+M ++ Y+ K ++K GK+QT RE KKKILAERRK
Sbjct: 117 KARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRK 176
Query: 215 VLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKT 274
L IDHL ED+LR+KAKELW++++ LE +KF+ EK K+QKY+I LR+RI+ QK SK
Sbjct: 177 PLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDITTLRSRIDQAQKHSKK 236
Query: 275 RG---KAKVTGRWK 285
G K KV GRWK
Sbjct: 237 AGTPAKGKVGGRWK 250
>gi|112789538 troponin T3, skeletal, fast isoform 2 [Homo sapiens]
Length = 256
Score = 300 bits (768), Expect = 1e-81
Identities = 159/259 (61%), Positives = 200/259 (77%), Gaps = 9/259 (3%)
Query: 31 DAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDI 90
D E E + EE EE+E +EEA E + + E + KPR P L PKIP+GE+VDFDDI
Sbjct: 3 DEEVE-QVEEQYEEEEEAQEEAAEVHE-EVHEPEEKPR---PKLTAPKIPEGEKVDFDDI 57
Query: 91 HRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQN 150
+KR KDL ELQALI++HFE RKKEEEELV+LK+RIE+RRAERAEQQRIR E+E+ERQN
Sbjct: 58 QKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQN 117
Query: 151 RLAEERARREEEENRRKAEDEARKKKALSNM-MHFGGYIQKTERKSGKRQTEREKKKKIL 209
RLAEE+ARREEE+ +R+AED+ +KKKALS+M ++ Y+ K ++K GK+QT RE KKKIL
Sbjct: 118 RLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKIL 177
Query: 210 AERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQ 269
AERRK L IDHL ED+LR+KAKELW++++ LE +KF+ EK K+QKY+I LR+RI+ Q
Sbjct: 178 AERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDITTLRSRIDQAQ 237
Query: 270 KVSKTRG---KAKVTGRWK 285
K SK G K KV GRWK
Sbjct: 238 KHSKKAGTPAKGKVGGRWK 256
Score = 32.0 bits (71), Expect = 0.64
Identities = 36/193 (18%), Positives = 77/193 (39%), Gaps = 21/193 (10%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
I+ E ++EE+E A++E+ E + AE + RAE++ E + E EE
Sbjct: 73 IDSHFEARKKEEEELVALKERIEKRRAE---RAEQQRIRAEKERERQNRLAEEKARREEE 129
Query: 64 KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSL 123
D +R DD+ +K+ + + A + ++ +++ +
Sbjct: 130 -----------------DAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREM 172
Query: 124 KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMH 183
K +I R + + ++ +++ L E + E + E R+K ++ +
Sbjct: 173 KKKILAERRKPLNIDHLGEDKLRDKAKEL-WETLHQLEIDKFEFGEKLKRQKYDITTLRS 231
Query: 184 FGGYIQKTERKSG 196
QK +K+G
Sbjct: 232 RIDQAQKHSKKAG 244
>gi|112789536 troponin T3, skeletal, fast isoform 3 [Homo sapiens]
Length = 250
Score = 292 bits (748), Expect = 2e-79
Identities = 152/254 (59%), Positives = 194/254 (76%), Gaps = 9/254 (3%)
Query: 36 AETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRM 95
++ E + EE EEEE + E+ EE KP+P+ L PKIP+GE+VDFDDI +KR
Sbjct: 2 SDEEVEQVEEQYEEEEEAQEEEEVQEEEKPRPK-----LTAPKIPEGEKVDFDDIQKKRQ 56
Query: 96 EKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEE 155
KDL ELQALI++HFE RKKEEEELV+LK+RIE+RRAERAEQQRIR E+E+ERQNRLAEE
Sbjct: 57 NKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEE 116
Query: 156 RARREEEENRRKAEDEARKKKALSNM-MHFGGYIQKTERKSGKRQTEREKKKKILAERRK 214
+ARREEE+ +R+AED+ +KKKALS+M ++ Y+ K ++K GK+QT RE KKKILAERRK
Sbjct: 117 KARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRK 176
Query: 215 VLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKT 274
L IDHL ED+LR+KAKELW++++ LE +KF+ EK K+QKY+I +R R+ K SK
Sbjct: 177 PLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDIMNVRARVQMLAKFSKK 236
Query: 275 RG---KAKVTGRWK 285
G K KV GRWK
Sbjct: 237 AGTPAKGKVGGRWK 250
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 73.6 bits (179), Expect = 2e-13
Identities = 74/289 (25%), Positives = 133/289 (46%), Gaps = 44/289 (15%)
Query: 9 EEYEEEEQEEAAVEEQEEAAE-----EDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
EE E QE +EE E + + +AE +E + +E+EEEE+ K G +
Sbjct: 150 EEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVE 209
Query: 64 ---KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
+ K V + +G+ + + E+ +E+ +H E ++E++E
Sbjct: 210 VMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEI-----SHHEKMEEEDKE- 263
Query: 121 VSLKDRIERRRAERAEQQRIRNEREK------------------ERQNRLAEERARREEE 162
+ ER R E E++RI+ E++K ER+ R AEER R EE
Sbjct: 264 ---RAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREE 320
Query: 163 ENRRKAEDEARKKKALSNMMHFGGYIQKTERKSG-KRQTEREKKKKILAERRKVLAIDHL 221
E +R AE+ R K+ I++ E+++ +RQ +E++K+ ER++ A
Sbjct: 321 E-KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARA---- 375
Query: 222 NEDQLREKAKELWQSIYNLEAEKFDLQE-KFKQQKYEINVLRNRINDNQ 269
E++ + K +E ++ LE +K +QE K K +K E + +N+ +
Sbjct: 376 -EEEEKAKVEEQKRN-KQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKK 422
Score = 72.8 bits (177), Expect = 3e-13
Identities = 67/288 (23%), Positives = 133/288 (46%), Gaps = 26/288 (9%)
Query: 10 EYEEEEQEEAAVEEQEEAAEEDAEAEAETEETR----AEEDEEEEEAKEAEDGPMEESKP 65
E E E+EE + QE E+ E ++ + AEE+++E++ KE E EE KP
Sbjct: 143 ENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEE----EEEKP 198
Query: 66 KPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKD 125
K S N V + + ++ ++ N + E E +++ + +S +
Sbjct: 199 KRGSIGENQVEVMVEEKTTESQEETVVMSLK---NGQISSEEPKQEEEREQGSDEISHHE 255
Query: 126 RIERRRAERAEQQRIRNEREK------ERQNRLAEERARREEEENRRKAEDEARKKKALS 179
++E ERAE +R R E E+ E+ ++A+ERAR E EE E E R+ +
Sbjct: 256 KMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERE 315
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYN 239
M ++ +R + +RQ +E++K+ ER+++ + ++ + +E ++
Sbjct: 316 RMR------EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 369
Query: 240 LEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRG---KAKVTGRW 284
+ + + +EK K ++ + N + +K +G + K+ G+W
Sbjct: 370 RQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKW 417
Score = 68.2 bits (165), Expect = 8e-12
Identities = 63/279 (22%), Positives = 123/279 (44%), Gaps = 32/279 (11%)
Query: 2 SDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
+ +E +VEE E QEE V + E + E E + ++ E E ED
Sbjct: 206 NQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERA 265
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKD--LNELQALIEAHFENRKKEEEE 119
E+ + R++ ++ R + E+D + + +A IEA + +E E
Sbjct: 266 EA-----------------ERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERE- 307
Query: 120 LVSLKDRIERRRAERAEQQRIRNERE--KERQNRLAEERARREEEENRRKAEDEARKKKA 177
+ E R R E++R ER+ KE + R AEER R +EEE +R AE+ R K+
Sbjct: 308 ----RREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE-KRAAEERQRIKEE 362
Query: 178 LSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI 237
+ E + K + E +K+ K L E++ + + +++ +K + W +
Sbjct: 363 EKRAAEERQRARAEEEE--KAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNE 420
Query: 238 YNLEAEKFD---LQEKFKQQKYEINVLRNRINDNQKVSK 273
+ +K L+++ +++ ++ R ++ +++ K
Sbjct: 421 KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFK 459
Score = 58.5 bits (140), Expect = 6e-09
Identities = 67/281 (23%), Positives = 116/281 (41%), Gaps = 50/281 (17%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE--EEEEAKEAEDGPMEESKPK 66
E+ EEE++E A E AEE +AE ++ A+E E EE A++ E++ +
Sbjct: 255 EKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEER 314
Query: 67 PRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDR 126
R R+ ++ E Q + K+EE+ + R
Sbjct: 315 ERM----------------------REEEKRAAEERQRI--------KEEEKRAAEERQR 344
Query: 127 IERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGG 186
I+ AE++ +R KE + R AEER R EE + +E ++ K L H
Sbjct: 345 IKEEEKRAAEER----QRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH--- 397
Query: 187 YIQKTERKSGKRQTEREKK----KKILAERRKVLAIDHLNEDQ------LREKAKELWQS 236
+Q+T+ K K + + E K KK ++ + + E++ REK +E +
Sbjct: 398 AMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQE-DKP 456
Query: 237 IYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGK 277
+ E K + +K K+ K E+ +R +V G+
Sbjct: 457 TFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGE 497
Score = 52.0 bits (123), Expect = 6e-07
Identities = 48/197 (24%), Positives = 94/197 (47%), Gaps = 42/197 (21%)
Query: 12 EEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME------ESKP 65
++ E++ V+ + E +ED + + EE + E+ ++++E KE M+ E K
Sbjct: 435 KQGEEKGTKVQAKREKLQED-KPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKS 493
Query: 66 KPRSFMPNLVP-----------------------PKIPDGERVDFDDIHRKRMEKDLNEL 102
+ FM + + P++ G+R++ ++ R+R E + E
Sbjct: 494 QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE--ELRRRRGETESEEF 551
Query: 103 QALIEAHFENRKKEEE---ELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARR 159
+ L ++K++E EL LK + E RR E+++ R + E +R+ R EE+ R
Sbjct: 552 EKL-------KQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRL 604
Query: 160 EEEENRRKAEDEARKKK 176
+EE RR+AE +++K
Sbjct: 605 KEEIERRRAEAAEKRQK 621
Score = 47.8 bits (112), Expect = 1e-05
Identities = 71/313 (22%), Positives = 127/313 (40%), Gaps = 60/313 (19%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEE-----DAEAEAETEETRAEED-------------EEEE 50
EE E+ + EE++ AAEE + E A E R +E+ EEEE
Sbjct: 320 EEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEE 379
Query: 51 EAK----------EAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIH----RKRME 96
+AK E + M+E+K K + + K + ++ D + +K+ E
Sbjct: 380 KAKVEEQKRNKQLEEKKHAMQETKIKGEK-VEQKIEGKWVNEKKAQEDKLQTAVLKKQGE 438
Query: 97 KDLNELQALIEAHFENR---KKEE-------------EELVSLKDRIERRRAERAEQQRI 140
+ ++QA E E++ KKEE EE+ S DR + +++
Sbjct: 439 EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEF 498
Query: 141 RNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGG-----YIQKTERKS 195
+ K +N + R + + + K L + G +K ++K
Sbjct: 499 MTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQ 558
Query: 196 GKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQK 255
+ E E+ KK ERRKV L E++ R K +E + + E EK L+E+ ++++
Sbjct: 559 QEAALELEELKKKREERRKV-----LEEEEQRRKQEEADRKLRE-EEEKRRLKEEIERRR 612
Query: 256 YEINVLRNRINDN 268
E R ++ ++
Sbjct: 613 AEAAEKRQKMPED 625
Score = 47.0 bits (110), Expect = 2e-05
Identities = 46/219 (21%), Positives = 100/219 (45%), Gaps = 16/219 (7%)
Query: 12 EEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE-EEEEAKEAEDGPMEESKPKPRSF 70
+E++ + A +++Q E E+ + +A+ E+ + ++ ++EE K+ + +E K + +SF
Sbjct: 424 QEDKLQTAVLKKQGE--EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSF 481
Query: 71 MPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERR 130
M + +F K E + A + ++ E V R+E
Sbjct: 482 MDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG--RASVDTKEAEGAPQVEAGKRLEEL 539
Query: 131 RAERAEQQRIRNEREKERQNRLAEE----RARREEEENRRKAEDEARKKKALSNMMHFGG 186
R R E + E+ K++Q A E + +REE + E++ RK++ +
Sbjct: 540 RRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL---- 595
Query: 187 YIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQ 225
+ E + + + E E+++ AE+R+ + D L++D+
Sbjct: 596 ---REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDK 631
Score = 38.5 bits (88), Expect = 0.007
Identities = 34/171 (19%), Positives = 71/171 (41%), Gaps = 8/171 (4%)
Query: 107 EAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARR------- 159
E E R+++ EE+ +RI +R + E++ R R + RQ RL +++
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 160 EEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAID 219
+ E N + + + K +N G + +R+ R+K+ + ER+K
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD-P 123
Query: 220 HLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 270
+ + L ++ + E + + + + +Q++YEI QK
Sbjct: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQK 174
Score = 38.5 bits (88), Expect = 0.007
Identities = 50/247 (20%), Positives = 93/247 (37%), Gaps = 48/247 (19%)
Query: 23 EQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDG 82
E E+ EAE + +D+EEE A+E
Sbjct: 9 ELRRQKREEMRLEAERIAYQRNDDDEEEAARERR-------------------------- 42
Query: 83 ERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRN 142
R + + +K+ E+ L ++ +E + +N +EE + + E A +R+
Sbjct: 43 RRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLA- 101
Query: 143 EREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTER 202
RE+ RQ RL E R++E + + + + N + TE+
Sbjct: 102 RREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQN------------DTAENETTEK 149
Query: 203 EKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLR 262
E+K + ER ++ E + K W+ +AE+ ++K K+++ E R
Sbjct: 150 EEKSESRQERYEI----EETETVTKSYQKNDWR-----DAEENKKEDKEKEEEEEEKPKR 200
Query: 263 NRINDNQ 269
I +NQ
Sbjct: 201 GSIGENQ 207
Score = 34.7 bits (78), Expect = 0.098
Identities = 30/112 (26%), Positives = 50/112 (44%), Gaps = 3/112 (2%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + EEEEQ E + EE+ + + E R + E+ K EDG ++ K
Sbjct: 573 EERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 632
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKE 116
P + F P KI ER +F + ++ + QA I + ++R ++
Sbjct: 633 PF-KCFTPKGSSLKIE--ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQ 681
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 73.2 bits (178), Expect = 2e-13
Identities = 68/265 (25%), Positives = 120/265 (45%), Gaps = 40/265 (15%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPR 68
+E +E E+E E + E E E E E E R E E+E E + D + +K + R
Sbjct: 300 KERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDR 359
Query: 69 SFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIE 128
D +R D R+R D N+ ++ +R++E E ++R
Sbjct: 360 ------------DRDRERDRDRDRER-SSDRNKDRSRSREKSRDRERERER---ERERER 403
Query: 129 RRRAERAEQQRIRNEREKERQNRLAEERARREEEEN---RRKAEDEARKKKALSNMMHFG 185
R ER ++ ERE+ER+ ++R R E+EE+ RRK E + R+K+A +
Sbjct: 404 EREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAA-----YQ 458
Query: 186 GYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKF 245
++ E + K+ E EK+ + ERR+ +A ++AK L + + + + ++
Sbjct: 459 ERLKNWEIRERKKTREYEKEAEREEERRREMA----------KEAKRLKEFLEDYDDDRD 508
Query: 246 DLQEKFKQQKYEINVLRNRINDNQK 270
D + Y + L+ R+ D +K
Sbjct: 509 D------PKYYRGSALQKRLRDREK 527
Score = 65.1 bits (157), Expect = 7e-11
Identities = 47/171 (27%), Positives = 83/171 (48%), Gaps = 8/171 (4%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
D EE E+ E + E + E+E A +E + E + E E+E E +E M +
Sbjct: 432 DREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAK 491
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ + F+ + D +R D ++K L + + +EA +RK+E+EEL
Sbjct: 492 EAKRLKEFLEDY------DDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEE 545
Query: 123 LKDRI--ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDE 171
++ R+ E AE QR+ E E+ RQ ++ +E EEEE +++ E++
Sbjct: 546 IRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEK 596
Score = 62.4 bits (150), Expect = 4e-10
Identities = 73/293 (24%), Positives = 124/293 (42%), Gaps = 39/293 (13%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEE-DEEEEEAKEAE----- 56
+IE+ E E E + E E+E E + E E E E R E D + + KE +
Sbjct: 304 EIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDR 363
Query: 57 --DGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRK 114
D + + R+ + K D ER + R+R + E + E E +
Sbjct: 364 ERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERERER 423
Query: 115 KEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLA-------------EERARREE 161
+ E++ ++ E ER + +R E+E Q RL E+ A REE
Sbjct: 424 EREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREE 483
Query: 162 EENRRKAEDEARKKKALSN--------MMHFGGYIQKTERKSGKR----QTEREKKKKIL 209
E R A++ R K+ L + + G +QK R K + +R+++K+ L
Sbjct: 484 ERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEEL 543
Query: 210 AE-RRKVLAIDHLNED----QLREKAKELWQSIYNLEAEKFDLQEKFKQQKYE 257
E R+++LA H + D ++ ++A+ Q E E + +E+ KQ+K E
Sbjct: 544 EEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPES-EEEEEEKQEKEE 595
Score = 61.6 bits (148), Expect = 8e-10
Identities = 67/291 (23%), Positives = 121/291 (41%), Gaps = 45/291 (15%)
Query: 18 EAAVEEQEEAAEEDAEAEAETEETRAE------EDEEEEEAKEAEDGPMEESKPKPRSFM 71
E + EEA +E+ + + + E E ++E++ P ++ K K
Sbjct: 186 ETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIF 245
Query: 72 PNL-VPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF---------ENRKKEEEELV 121
V P IP + +DI+ ME+D +L + + F E KKE+E
Sbjct: 246 RRFPVAPLIPY-PLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQE 304
Query: 122 SLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEE---------------NRR 166
K+R ER R E++R ERE+ER+ +E+ R E E +R
Sbjct: 305 IEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRE 364
Query: 167 KAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQL 226
+ D R++ + N ++ KS R+ ERE++++ ER + + E +
Sbjct: 365 RDRDRDRERSSDRNKDR-----SRSREKSRDRERERERERERERERERERERERERERE- 418
Query: 227 REKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGK 277
RE+ +E E +K +E+ ++ YE L ++ + + + R K
Sbjct: 419 RERERE-------REKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLK 462
Score = 57.8 bits (138), Expect = 1e-08
Identities = 49/224 (21%), Positives = 99/224 (44%), Gaps = 19/224 (8%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
D E E E E+E E+E E + E E E E+ + + EE+EE +
Sbjct: 390 DREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERK 449
Query: 63 SKPKPRSFMPNLVPPKIPDGERV-------DFDDIHRKRMEKDLNELQALIEAHFENRKK 115
+ K ++ L +I + ++ + ++ R+ M K+ L+ +E + ++R
Sbjct: 450 LREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDD 509
Query: 116 EEEELVS-----LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAED 170
+ S L+DR + A+ +++R + E E+ RQ LAE + E R + E
Sbjct: 510 PKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEA 569
Query: 171 EARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRK 214
E R++ + ++E + ++Q + EK+++ + E +
Sbjct: 570 ERRRQPQIKQE-------PESEEEEEEKQEKEEKREEPMEEEEE 606
Score = 34.7 bits (78), Expect = 0.098
Identities = 23/73 (31%), Positives = 38/73 (52%), Gaps = 6/73 (8%)
Query: 2 SDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
++++ + +E E Q + +QE +EE+ E + E EE R E EEEE E E P
Sbjct: 560 AELQRMEQEAERRRQPQI---KQEPESEEEEEEKQEKEEKREEPMEEEE---EPEQKPCL 613
Query: 62 ESKPKPRSFMPNL 74
+ +P S P++
Sbjct: 614 KPTLRPISSAPSV 626
Score = 30.4 bits (67), Expect = 1.9
Identities = 18/72 (25%), Positives = 29/72 (40%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
+ ++ E + E EQE + + E E EE+++E+E K E EE
Sbjct: 548 QRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEP 607
Query: 65 PKPRSFMPNLVP 76
+ P L P
Sbjct: 608 EQKPCLKPTLRP 619
Score = 28.5 bits (62), Expect = 7.0
Identities = 17/72 (23%), Positives = 29/72 (40%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
+E +EE + E + E + EAE + +E E EEE +E ++ + +
Sbjct: 540 KEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREE 599
Query: 65 PKPRSFMPNLVP 76
P P P
Sbjct: 600 PMEEEEEPEQKP 611
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 73.2 bits (178), Expect = 2e-13
Identities = 59/229 (25%), Positives = 102/229 (44%), Gaps = 18/229 (7%)
Query: 24 QEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGE 83
Q E E + E E E + E E ++E +E E E K + R K GE
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRER-----GKKEKKGE 89
Query: 84 RVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNE 143
R + +KR + EN++ EE+E K++ ER R + ++R R E
Sbjct: 90 RKKEERERKKRRREK------------ENKEGEEKEKRKKKEKKERGRTSKEGKERERKE 137
Query: 144 REKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTERE 203
E++R+ R ER + E E+ R + E + R++K + ++ ERK +R +
Sbjct: 138 -ERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKER 196
Query: 204 KKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFK 252
KK++ ERR+ E++ +E+ K+ + E K + +E+ K
Sbjct: 197 KKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 72.0 bits (175), Expect = 6e-13
Identities = 58/225 (25%), Positives = 103/225 (45%), Gaps = 27/225 (12%)
Query: 10 EYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRS 69
E E E+E +E ++ E + + E E R E E+E + + + E K + R
Sbjct: 37 EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERE 96
Query: 70 FMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIER 129
+ +GE + KR +K+ E + E +KE ER
Sbjct: 97 RKKRRREKENKEGEEKE------KRKKKEKKERGRTSKEGKERERKE-----------ER 139
Query: 130 RRAERAEQQRIRNEREKERQNRLAEERARR---EEEENRRKAEDEARKKKALSNMMHFGG 186
+R ER E++R + EREKER+ + ++R R+ E+EE R++ E + RKK+ +
Sbjct: 140 KREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRK----- 194
Query: 187 YIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK 231
++ + + K + ER+K++K ER+K D + +E+ K
Sbjct: 195 --ERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGK 237
Score = 66.6 bits (161), Expect = 2e-11
Identities = 55/204 (26%), Positives = 99/204 (48%), Gaps = 28/204 (13%)
Query: 5 EEVVEEYEEEEQEEAAVEEQE-EAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
E+ E E+E + E +E++ E +E+ E + E +E EE+E+ K+ +E
Sbjct: 67 EKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKK------KEK 120
Query: 64 KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSL 123
K + R+ + + +R + + RK+ E++ E + RKK E + V
Sbjct: 121 KERGRTSKEGKERERKEERKREERKERERKKEEREK-------ERERKERKKRERKQVGE 173
Query: 124 K--DRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNM 181
K +R E+ R ER +++R R ER+KER ER R E + RK ++E +K++
Sbjct: 174 KEEERKEKERKERKKRERNRKERKKER------ERKERRERKKERKKKEERKKERQKDRQ 227
Query: 182 MHFGGYIQKTERKSGKRQTEREKK 205
++ E++ GKR+ + KK
Sbjct: 228 TNW------REKERGKRERKERKK 245
Score = 64.7 bits (156), Expect = 9e-11
Identities = 50/187 (26%), Positives = 93/187 (49%), Gaps = 12/187 (6%)
Query: 96 EKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAER-AEQQRIRNEREK--ERQNRL 152
+ ++ E + IE E +K+ E E + E+R+ ER E++R R ++EK ER+
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 153 AEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAER 212
E + RR E+EN+ E E RKKK ++ ERK +++ ER+++++ ER
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154
Query: 213 RKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVS 272
K E + +E+ K + + E E+ + +E+ +++K E N + +K
Sbjct: 155 EK--------ERERKERKKRERKQVGEKEEERKE-KERKERKKRERNRKERKKERERKER 205
Query: 273 KTRGKAK 279
+ R K +
Sbjct: 206 RERKKER 212
Score = 28.9 bits (63), Expect = 5.4
Identities = 16/65 (24%), Positives = 28/65 (43%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
+ E EE +E+E++E E+ + E E + E ++EE KE +
Sbjct: 171 VGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNW 230
Query: 64 KPKPR 68
+ K R
Sbjct: 231 REKER 235
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 72.8 bits (177), Expect = 3e-13
Identities = 61/263 (23%), Positives = 129/263 (49%), Gaps = 48/263 (18%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
+E + E EE+ QEE + EQE+ E++A+ + E+ R E+EE+ +E E + +
Sbjct: 389 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR----EQEEKIREQEKKMWRQEE 444
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
KI + E++ ++ KR E++ Q E + +E+EE+ K
Sbjct: 445 -------------KIHEQEKIREEE---KRQEQEEMWRQ-------EEKIREQEEIWRQK 481
Query: 125 DRIERRRAERAEQQRIRNEREK----ERQNRLAEERARREEE---ENRRKAEDEARKKKA 177
+++ + R +++++ + EK E + R EE+ R+EE E K ++ K +
Sbjct: 482 EKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIRE 541
Query: 178 LSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHL---NEDQLREKAKELW 234
MM Q+ E K G+++ + ++++K+ + K+ + ++++RE+ +++W
Sbjct: 542 QEEMM------QEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIW 595
Query: 235 QSIYNLEAEKFDLQEKFKQQKYE 257
+ + EK QE+ Q++ E
Sbjct: 596 E-----QEEKIREQEEMMQEQEE 613
Score = 66.2 bits (160), Expect = 3e-11
Identities = 68/292 (23%), Positives = 138/292 (47%), Gaps = 40/292 (13%)
Query: 4 IEEVVEEYEEEE----QEEAAVEEQEEAAEEDAEAEAETEETRAEEDE---EEEEAKEAE 56
I+E E+ +E+E ++E + EQEE E E EE ++E E+EE
Sbjct: 309 IQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRL 368
Query: 57 DGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEK-----DLNELQALIEAHFE 111
+ M E + K R + K+ + E++ + R+ EK E +A + E
Sbjct: 369 EEMMWEKEEKIRE-----LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 423
Query: 112 NRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDE 171
+++EE++ + ++ R+ + EQ++IR E +++ Q E R+EE+ R + E
Sbjct: 424 KIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQ-----EEMWRQEEKIREQEEIW 478
Query: 172 ARKKKALSNMMHFGGYIQKTERKSGKRQTE--------REKKKKILAERRKVLAIDHL-- 221
+K+K MH I+K E K +++ + RE+++K+ + K+ +
Sbjct: 479 RQKEK-----MHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIR 533
Query: 222 -NEDQLREKAKELWQSIYNL--EAEKFDLQEKFKQQKYEINVLRNRINDNQK 270
E+++RE+ + + + + + EK QEK ++Q+ +I +I + ++
Sbjct: 534 EQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKE 585
Score = 60.1 bits (144), Expect = 2e-09
Identities = 56/282 (19%), Positives = 125/282 (44%), Gaps = 68/282 (24%)
Query: 4 IEEVVEEYE-----EEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE--EEEEAKEAE 56
++ VEE E ++QEE ++E+ E + + + + E+ R +E++ E+EE +
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 340
Query: 57 DGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKE 116
+ M E + K R R E+ + E + E ++
Sbjct: 341 EEMMWEKEEKMR-------------------------RQEEMMWEKE-------EKMRRL 368
Query: 117 EEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKK 176
EE + +++I + EQ++IR + EK ++ E+ +R+E+E + ++E
Sbjct: 369 EEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK---- 424
Query: 177 ALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQS 236
I++ E K RE++KK+ + K+ + + E++ R++ +E+W+
Sbjct: 425 -----------IREQEEKI------REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQ 467
Query: 237 IYNL--------EAEKFDLQEKFKQQKYEINVLRNRINDNQK 270
+ + EK QEK ++Q+ ++ +++D ++
Sbjct: 468 EEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEE 509
Score = 57.8 bits (138), Expect = 1e-08
Identities = 55/272 (20%), Positives = 130/272 (47%), Gaps = 24/272 (8%)
Query: 25 EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGER 84
EE E++A+ + + + +E+ E + KE ++ + + +P D
Sbjct: 217 EELKEKNAKLQEKLQLVESEKSEIQLNVKE-----LKRKLERAKLLLPQQQLQAEADHLG 271
Query: 85 VDFDDIHRK-RMEKDLNEL-QALIEAHFENRKKEEEELVSLKDRIERRRAE-RAEQQRIR 141
+ + K + + + NEL L + E ++EE++ +++I+ + + R ++++IR
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331
Query: 142 NEREKERQNRLA----EERARREEE------ENRRKAED----EARKKKALSNMMHFGGY 187
+ EK R+ EE+ RR+EE E R+ E+ + K + L MH
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEK 391
Query: 188 IQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNE--DQLREKAKELWQSIYNLEAEKF 245
I++ E K + + RE++K+ E + + + E +++RE+ K++W+ + ++
Sbjct: 392 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK 451
Query: 246 DLQEKFKQQKYEINVLRNRINDNQKVSKTRGK 277
+E+ +Q++ E+ +I + +++ + + K
Sbjct: 452 IREEEKRQEQEEMWRQEEKIREQEEIWRQKEK 483
Score = 54.3 bits (129), Expect = 1e-07
Identities = 42/173 (24%), Positives = 85/173 (49%), Gaps = 15/173 (8%)
Query: 1 MSDIEEVVEEYEEEE-QEEAAVEEQEEAAEEDAEAEAETEETRAEEDE----EEEEAKEA 55
M D EE + E EE+ ++E + EQEE E E E EE E++E +EE+ +E
Sbjct: 504 MHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQ 563
Query: 56 EDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK 115
E +E K + + KI + E ++ E+ + E + +++ E +
Sbjct: 564 EKMRRQEEKIREQEEKIREQKEKIREQEEKIWE------QEEKIREQEEMMQEQEEKMWE 617
Query: 116 EEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKA 168
+EE++ +++++ E+ E+ R + E+ E++ RL ++ + +E + +A
Sbjct: 618 QEEKMCEQEEKMQ----EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666
Score = 30.8 bits (68), Expect = 1.4
Identities = 26/143 (18%), Positives = 66/143 (46%), Gaps = 12/143 (8%)
Query: 128 ERRRAERAEQQRIRNEREKERQN-------RLAEERARREEEENRRKAEDEARKK-KALS 179
+ ++A Q+ +R E E + + + A + ++ E EAR L
Sbjct: 109 DEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH 168
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAID----HLNEDQLREKAKELWQ 235
+ F G +++ ++ + ++ + L + R L+++ + +++L+EK +L +
Sbjct: 169 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 228
Query: 236 SIYNLEAEKFDLQEKFKQQKYEI 258
+ +E+EK ++Q K+ K ++
Sbjct: 229 KLQLVESEKSEIQLNVKELKRKL 251
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 72.8 bits (177), Expect = 3e-13
Identities = 62/253 (24%), Positives = 119/253 (47%), Gaps = 33/253 (13%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
+E+ E +EEEQ++ + +++ + E E +E R E+ E E+ +E + + +
Sbjct: 284 QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ 343
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKE--EEELVS 122
+ R + R+ E++ E Q E E R+++ E+ +
Sbjct: 344 EERR-------------------EQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
+ ++ R + R EQQ +R E++ R+ +L E+ R E++ RR+ E+E ++K
Sbjct: 385 REQQLRREQQLRREQQ-LRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR 443
Query: 183 HFGGYIQKTERKSG-KRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLE 241
++ ER+ KR+ E E+ ++ ERRK L DQ E+ +E W + E
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQ---ERRK----QQLKRDQ-EEERRERWLKLE--E 493
Query: 242 AEKFDLQEKFKQQ 254
E+ + QE+ +QQ
Sbjct: 494 EERREQQERREQQ 506
Score = 72.8 bits (177), Expect = 3e-13
Identities = 62/259 (23%), Positives = 122/259 (47%), Gaps = 21/259 (8%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE----EEEEAKEAEDGP 59
++E EE + EE+E+ +EQE E+ + + E E+ EE E +E E + +D
Sbjct: 906 LQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK 965
Query: 60 MEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE 119
+++ + + L+ + R + + +R+ E E Q L E + R++E E
Sbjct: 966 LQQKEEQ-------LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWER 1018
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREK----ERQNRLAEERARREEEENRRKAEDEARKK 175
KD +++ E+Q +R EREK ER+ + EE ++EEE E E R++
Sbjct: 1019 QYRKKDELQQE-----EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073
Query: 176 KALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLR-EKAKELW 234
+ L +Q+ E + + + E+ ++++ + R+ + E LR E+ K
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR 1133
Query: 235 QSIYNLEAEKFDLQEKFKQ 253
Q + E+ ++Q++ +Q
Sbjct: 1134 QELERQYREEEEVQQEEEQ 1152
Score = 72.8 bits (177), Expect = 3e-13
Identities = 71/297 (23%), Positives = 132/297 (44%), Gaps = 60/297 (20%)
Query: 5 EEVVEEYEE----EEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE------------E 48
EE +++ EE EE+E+ +E+E +D + + + E+ EE E E
Sbjct: 933 EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYRE 992
Query: 49 EEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEA 108
EEE ++ E+ + E + K R R +++ +RK+ E E Q L E
Sbjct: 993 EEELQQEEEQLLREEREKRR---------------RQEWERQYRKKDELQQEEEQLLREE 1037
Query: 109 HFENRKKE-------------EEELVSLKDRIERRRAE------------RAEQQRIRNE 143
+ R +E EEE + ++R RRR E + E+Q +R E
Sbjct: 1038 REKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREE 1097
Query: 144 REK----ERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQ 199
EK ER+ + EE ++EEE + E E R+++ L +Q+ E + + +
Sbjct: 1098 PEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREE 1157
Query: 200 TEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKY 256
E+ +++++ + R+ + E LRE+ ++ Q E+ +LQ + ++Q+Y
Sbjct: 1158 PEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Score = 72.0 bits (175), Expect = 6e-13
Identities = 63/261 (24%), Positives = 122/261 (46%), Gaps = 19/261 (7%)
Query: 5 EEVVEEYEEE---EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
E+++ E E+ ++ E E+EE +E+ + E ETR ++ E + KE E E
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090
Query: 62 ES--KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE 119
E + +P + + E + ++ R E++ Q L + E + ++EE
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALS 179
L++ E+RR + E+Q RE+E + E+ R E+E+ R++ E + R+++ L
Sbjct: 1151 EQLLREEPEKRRRQELERQY----REEEELQQEEEQLLREEQEKRRQERERQYREEEELQ 1206
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKK-----KKILAERRKVLAIDHLNEDQLREKAKELW 234
Y + +R K Q E EK+ K+ + R+ L + QLR++ +
Sbjct: 1207 RQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQ-- 1264
Query: 235 QSIYNLEAEKFDLQEKFKQQK 255
Q + +L E+ QE+ ++Q+
Sbjct: 1265 QDLQHLLGEQ---QERDREQE 1282
Score = 69.7 bits (169), Expect = 3e-12
Identities = 67/289 (23%), Positives = 138/289 (47%), Gaps = 22/289 (7%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE E+ E+E+ E ++ ++E + + E ETE R E++ +++ K ++ E
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETE--RHEQERRKQQLKRDQEEERRERW 488
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNE--LQALIEAHFENRKKEEEELVS 122
K + R + ++ +R+++ E LQ + + + R+++EE
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 123 LKDRIERRRAER-AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNM 181
L R E +R E+ +QR++ E+E+ R L E RR++ R K E E R ++ L
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQ---RLKREQEERLEQRLKR- 604
Query: 182 MHFGGYIQKTER-KSGKRQTEREKKKKILAERRKVLAIDHLNED----QLREKAKELWQS 236
++ ER + +R+ +R K+++ ERR+ L E+ QLR + +E +
Sbjct: 605 -------EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Query: 237 IYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGRWK 285
E E+ L+++ K++ E + + Q+ ++ R K+++ +W+
Sbjct: 658 RLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIP-KWQ 705
Score = 66.6 bits (161), Expect = 2e-11
Identities = 59/258 (22%), Positives = 119/258 (46%), Gaps = 27/258 (10%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGP----- 59
E+ + E E+E +EE+E+ + + + EE +ED+E ++E
Sbjct: 818 EQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ 877
Query: 60 MEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE 119
+EE + + R + P + + R + + + E E + E + +EEE+
Sbjct: 878 LEEERKRRRHTL--YAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ 935
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALS 179
L ++++ R E+ +Q + K+++ + EE+ EE E RR+ E R+KK
Sbjct: 936 LQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE---REKK--- 989
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYN 239
Y ++ E + + Q RE+++K RR+ + +D+L+++ ++L +
Sbjct: 990 -------YREEEELQQEEEQLLREEREK---RRRQEWERQYRKKDELQQEEEQLLRE--- 1036
Query: 240 LEAEKFDLQEKFKQQKYE 257
E EK LQE+ +Q + E
Sbjct: 1037 -EREKRRLQERERQYREE 1053
Score = 65.9 bits (159), Expect = 4e-11
Identities = 60/265 (22%), Positives = 127/265 (47%), Gaps = 30/265 (11%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEET--RAEEDEEEEEAKEAEDGPM 60
++ E+ + EE+Q++ E Q+ +E+ E E ET R EE++ +EE + +
Sbjct: 214 ELLELRRKGREEKQQQRR-ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
EE + +++ ++ R+R E++ + Q + + R+K+EEE
Sbjct: 273 EEEEQL----------------RKLERQELRRERQEEE--QQQQRLRREQQLRRKQEEER 314
Query: 121 VSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
++ ER EQQ R ++E+ R+ +L E+ R E++ RR+ E+E R+++ L
Sbjct: 315 -------REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE-RREQQLRR 366
Query: 181 MMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHL-NEDQLREKAKELWQSIYN 239
Q+ R+ R+ ++ ++++ L +++ L E QLR + + +
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 240 LEAEKFDLQEKFKQQKYEINVLRNR 264
E E+ ++K +Q++ E + R +
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQ 451
Score = 65.5 bits (158), Expect = 5e-11
Identities = 63/262 (24%), Positives = 116/262 (44%), Gaps = 19/262 (7%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAET---EETRAEEDEEEEEAKEAEDGPME 61
EE E+ EE +++ E+QEE E+ E E ++ R E++EE E + + E
Sbjct: 312 EERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEE 371
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRK----RMEKDLNELQALIEAHFENRKKEE 117
+ + R ++ +++ + R+ R E+ L Q L R++EE
Sbjct: 372 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE 431
Query: 118 EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENR-----RKAEDEA 172
E R E++ + +QR++ E+E+ R EE R E+E R R E+E
Sbjct: 432 E-------RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER 484
Query: 173 RKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 232
R++ ++ E++ + Q ER +++ E + L +E QLR + +E
Sbjct: 485 RERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE 544
Query: 233 LWQSIYNLEAEKFDLQEKFKQQ 254
+ + E EK QE+ +Q+
Sbjct: 545 RREQLLKREEEKRLEQERREQR 566
Score = 65.5 bits (158), Expect = 5e-11
Identities = 54/249 (21%), Positives = 113/249 (45%), Gaps = 35/249 (14%)
Query: 14 EEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPN 73
EE+ + +E+E+ D + + EE +E EE++ ++ D E + + R
Sbjct: 1647 EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLR----- 1701
Query: 74 LVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAE 133
++R K L E Q L E + +EEE+L ++ + RR E
Sbjct: 1702 -----------------RQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE 1744
Query: 134 R----AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQ 189
R E++++R ERE+++ R +R REEE+ R++ E++ + + ++
Sbjct: 1745 RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLR 1804
Query: 190 KTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQE 249
+ + R +R+ K + E+ ++ E +LR++ +++ E+F QE
Sbjct: 1805 QEREEQQLRPQQRDGKYRWEEEQLQL----EEQEQRLRQERDRQYRA-----EEQFATQE 1855
Query: 250 KFKQQKYEI 258
K ++++ E+
Sbjct: 1856 KSRREEQEL 1864
Score = 64.7 bits (156), Expect = 9e-11
Identities = 58/247 (23%), Positives = 121/247 (48%), Gaps = 13/247 (5%)
Query: 14 EEQEEAAVEEQEEAAEEDAEAEAETEET--RAEED--EEEEEAKEAEDGPMEESKPK-PR 68
EE+++ E Q+ +E+ E E ET R EE+ +EEE ++ E EE K R
Sbjct: 224 EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283
Query: 69 SFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIE 128
+ + +R+ + R++ E++ E Q E R+++EE + ++
Sbjct: 284 QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR---EQQLR 340
Query: 129 RRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYI 188
R + ER EQQ +R E+E+ER+ E++ RRE+EE RR+ + ++ + +
Sbjct: 341 REQEERREQQ-LRREQEEERR----EQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395
Query: 189 QKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQ 248
++ ++ ++Q RE++ + + R+ + E++ E+ E + L+ E+ + +
Sbjct: 396 RREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455
Query: 249 EKFKQQK 255
+ K+++
Sbjct: 456 DWLKREE 462
Score = 64.3 bits (155), Expect = 1e-10
Identities = 55/237 (23%), Positives = 118/237 (49%), Gaps = 20/237 (8%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEED-----AEAEAETEETRAEEDEEEE-EAKEAEDG 58
E + E EE+ +++ +E+++ ++ + E EE RAEE++ + + E E+
Sbjct: 145 ERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEF 204
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDD-IHRKRMEKDLNELQALIEAHFENRKKEE 117
P EE + + +R + D + ++ EK+ + + ++ E ++EE
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE 264
Query: 118 -EELVSLKDRIER-RRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKK 175
+ L++ E+ R+ ER E +R R E E+++Q E++ RR++EE RR+ ++E R++
Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324
Query: 176 KALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 232
+ Q+ ER+ + + E+E++++ R + + E QLR + +E
Sbjct: 325 QERRE--------QQEERREQQLRREQEERREQQLRREQE---EERREQQLRREQEE 370
Score = 63.5 bits (153), Expect = 2e-10
Identities = 63/271 (23%), Positives = 122/271 (45%), Gaps = 30/271 (11%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKE------AEDG 58
E + E +++E+ + E+EE + + +E + E+EE+ + +E E+
Sbjct: 795 ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEED 854
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRK--KE 116
++E + + RS + R ++ RKR L AL E + ++ +E
Sbjct: 855 GLQEDQERRRS-----QEQRRDQKWRWQLEE-ERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 117 EEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKK 176
EEE + ++R +RRR E+ Q R + ++E + L EER +R +E R + RK K
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER----QYRKDK 964
Query: 177 ALSNMMHFGGYIQKTERKSGKRQTER---EKKKKILAERRKVLAIDHLNEDQLREKAKEL 233
L QK E+ G+ +R E++KK E + L ++ ++ ++
Sbjct: 965 KLQ---------QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015
Query: 234 WQSIYNLEAEKFDLQEKFKQQKYEINVLRNR 264
W+ Y + E +E+ +++ E L+ R
Sbjct: 1016 WERQYRKKDELQQEEEQLLREEREKRRLQER 1046
Score = 61.6 bits (148), Expect = 8e-10
Identities = 66/279 (23%), Positives = 123/279 (44%), Gaps = 30/279 (10%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKE--AEDGPM 60
D EE E + +EE E+QE ++ + E E R + EEEE ++ + +
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Query: 61 EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEEL 120
+ + R + K + ER + + R++ E+ L+ E + K+E+EE
Sbjct: 539 RREQEERREQLLKREEEKRLEQERRE-QRLKREQEERRDQLLKREEERRQQRLKREQEE- 596
Query: 121 VSLKDRIERRRAERAEQQRIRNER------EKERQNRLAEERARREEEENRRKAEDEARK 174
L+ R++R ER EQ+ R +R E+ER+ +L + + E + + + E + R+
Sbjct: 597 -RLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERR 655
Query: 175 KKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE-- 232
++ L ++ + KR+ E E++++ LAE ++Q RE+ K
Sbjct: 656 EQRLKREEE-----EERLEQRLKREHEEERREQELAEE---------EQEQARERIKSRI 701
Query: 233 -LWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 270
WQ + LE+E Q K + + R R +K
Sbjct: 702 PKWQ--WQLESEADARQSKVYSRPRKQEGQRRRQEQEEK 738
Score = 61.2 bits (147), Expect = 1e-09
Identities = 67/265 (25%), Positives = 127/265 (47%), Gaps = 20/265 (7%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES-- 63
E ++ +E+E +EE+++ +E E E+ E +E++ +E + +EE
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493
Query: 64 ---KPKPRSFMPNLVPPKIPDGERVDFD-DIHR-KRMEKDLNELQALIEAHFENRKKEEE 118
+ + R F + + P+ + ++ + +HR +R K L E Q L +++++
Sbjct: 1494 LRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR 1553
Query: 119 ELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKAL 178
+ ++ E+ R ER EQQ R ER +R+ RL E++ RR+E+E R+ EDE + ++
Sbjct: 1554 DRKFREE--EQLRQEREEQQLSRQER--DRKFRLEEQKVRRQEQE-RKFMEDEQQLRRQ- 1607
Query: 179 SNMMHFGGYIQKTERKSGKRQTEREKKKKILAER-RKVLAIDHLNEDQLREKAKELWQSI 237
+ R+ + ERE+++ ER RK L E QLR + +E Q +
Sbjct: 1608 EGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLE----EEPQLRRQERE--QQL 1661
Query: 238 YNLEAEKFDLQEKFKQQKYEINVLR 262
+ KF +E+ Q+ E + R
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRR 1686
Score = 60.8 bits (146), Expect = 1e-09
Identities = 62/275 (22%), Positives = 126/275 (45%), Gaps = 29/275 (10%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPR 68
EE +EQ +EE++ ++ E + EE + E E++ ++ D E + +
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQ-- 1422
Query: 69 SFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIE 128
L + R + + R+ E+ E + + + +EEE+L+
Sbjct: 1423 -----LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ------ 1471
Query: 129 RRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYI 188
ER EQQ R ER+++ L EE+ R +E +R+ E E R ++ + +
Sbjct: 1472 ----EREEQQLHRQERDRKF---LEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQL 1524
Query: 189 QKTERKSGKRQTERE-KKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAE-KFD 246
+ +R+ Q E++ ++++ +RR+ E+QLR++ +E Q + E + KF
Sbjct: 1525 HRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREE--QQLSRQERDRKFR 1582
Query: 247 LQE-KFKQQKYEINVLRNRINDNQKVSKTRGKAKV 280
L+E K ++Q+ E R + D Q++ + G+ ++
Sbjct: 1583 LEEQKVRRQEQE----RKFMEDEQQLRRQEGQQQL 1613
Score = 60.5 bits (145), Expect = 2e-09
Identities = 54/248 (21%), Positives = 110/248 (44%), Gaps = 14/248 (5%)
Query: 11 YEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEE----EAKEAEDGPMEESKPK 66
++EEE++E E EE+ E E + R ++EEE+ E +E EE + +
Sbjct: 238 FQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQ 297
Query: 67 PRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDR 126
R + K + R ++ ++ ++ E + + E ++ E++L ++
Sbjct: 298 QRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE 357
Query: 127 IERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGG 186
R + R EQ+ R E++ R+ +L E+ R E++ RR E + R+++ L
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRR--EQQLRREQQLRREQQLRR 415
Query: 187 YIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFD 246
Q + +R+ E E+ ++ + R+ E +L+ + +E + E +
Sbjct: 416 EQQLRREQQLRREQEEERHEQKHEQERR--------EQRLKREQEERRDWLKREEETERH 467
Query: 247 LQEKFKQQ 254
QE+ KQQ
Sbjct: 468 EQERRKQQ 475
Score = 60.1 bits (144), Expect = 2e-09
Identities = 52/230 (22%), Positives = 105/230 (45%), Gaps = 17/230 (7%)
Query: 9 EEYEEEEQEEAAVEEQEEAAE--EDAEAEAETEET-RAEEDEEEEEAKEAEDGPMEESKP 65
++ +E+E+E A EEQ E E E + + EE R ++ +E E + AE+ ++ K
Sbjct: 139 QKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKG 198
Query: 66 KPRSFMPNLVPPKIPDGERV---DFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ PD E++ + ++ RK E+ + + + F+ +++E
Sbjct: 199 HETE--------EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE 250
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
R E + + E QR R +E+E Q R E + R E + + + R+++ L
Sbjct: 251 TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ 310
Query: 183 HFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 232
Q+ ER+ + + E++++++ RR+ + E QLR + +E
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQ---EERREQQLRREQEE 357
Score = 58.2 bits (139), Expect = 8e-09
Identities = 64/292 (21%), Positives = 125/292 (42%), Gaps = 45/292 (15%)
Query: 9 EEYEEEEQEEAAVEEQE------EAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
EE EE Q++ E+QE + EE+ E + EE E+E A+E ++ E
Sbjct: 637 EEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARER 696
Query: 63 SKPKPRSFMPNLVP------------PKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF 110
K + + L P+ +G+R + ++R + + Q AH
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHR 756
Query: 111 ENRKKE-----------EEELVSLKDRI--------ERRRAERAEQQRIRNER----EKE 147
+ +++E EE+ + R+ +R R RAE+++ R +R E+E
Sbjct: 757 QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE 816
Query: 148 RQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKK 207
++ R + R R +E + + E R+++A G + ER+ + Q +K +
Sbjct: 817 KEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRW 876
Query: 208 ILAERRK----VLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQK 255
L E RK L ++QLR++ + L + L+ E+ + + + +Q++
Sbjct: 877 QLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928
Score = 57.8 bits (138), Expect = 1e-08
Identities = 61/277 (22%), Positives = 127/277 (45%), Gaps = 47/277 (16%)
Query: 9 EEYEEEEQEEAA-----VEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
E+ E EEQ+EA +E+++ E+ E + +ET + EEE+ +E E+ P+
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 64 KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSL 123
+ + R F + H+++ K L E Q L E + +EE+ +
Sbjct: 1357 E-RDRKFREEELR--------------HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRC 1401
Query: 124 KDRIERRRAERAEQQRIRNEREKERQ-NRLAEERARREEEENRRKAEDEARKKKALSNMM 182
++R ++ R Q R R RE+E+Q +R +R REEE+ R+ E E +
Sbjct: 1402 QEREQQLR-----QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERK--------- 1447
Query: 183 HFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEA 242
++++ ++ +R + +++++L ER + L+ + K E Q + E
Sbjct: 1448 ----FLEEEQQLRQERHRKFREEEQLLQEREE----QQLHRQERDRKFLEEEQQLRRQER 1499
Query: 243 EKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAK 279
++ +++ + Q+ E R + + Q++ + + + K
Sbjct: 1500 DRKFREQELRSQEPE----RKFLEEEQQLHRQQRQRK 1532
Score = 56.6 bits (135), Expect = 2e-08
Identities = 61/258 (23%), Positives = 123/258 (47%), Gaps = 35/258 (13%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEA---ETEETRAEEDEEEEEAKEAEDGPME 61
E+ + +EE +E+ E+E+ E++ + E EE R + + EEE ++ +
Sbjct: 535 EQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ 594
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
E + + R K + ER++ ++ +R++++ E E + K EE+
Sbjct: 595 EERLEQRL--------KREEVERLEQEERREQRLKREEPE-----EERRQQLLKSEEQEE 641
Query: 122 SLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAE--DEARKKKALS 179
+ ++ R + ER E QR++ E E+ER E+R +RE EE RR+ E +E +++
Sbjct: 642 RRQQQLRREQQERRE-QRLKREEEEER----LEQRLKREHEEERREQELAEEEQEQARER 696
Query: 180 NMMHFGGYIQKTERKSGKRQTE-REKKKKILAERRKVLAIDHLNEDQLREKAKEL-WQSI 237
+ + E ++ RQ++ + +K +RR+ E++ R + EL WQ
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRR-----QEQEEKRRRRESELQWQ-- 749
Query: 238 YNLEAEKFDLQEKFKQQK 255
E E+ Q++ ++Q+
Sbjct: 750 ---EEERAHRQQQEEEQR 764
Score = 56.2 bits (134), Expect = 3e-08
Identities = 63/287 (21%), Positives = 123/287 (42%), Gaps = 55/287 (19%)
Query: 10 EYEEEEQEEAAVEEQEEA--------AEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
+++EEE+ +E+E+ AEE +E + R E+ E AE+
Sbjct: 747 QWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK-----E 116
E + F+P E + + R+R E++ ELQ L E R++ +
Sbjct: 807 EQR-----FLP----------EEEEKEQRRRQRRERE-KELQFLEEEEQLQRRERAQQLQ 850
Query: 117 EEELVSLKDRIERRRAERAEQQRIRNEREKERQNRL----------------------AE 154
EEE +D+ RR E+ Q+ R + E+ER+ R E
Sbjct: 851 EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE 910
Query: 155 ERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRK 214
E +REE E RR+ E E + ++ +++ K +++ ER+ +K ++++
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKE 970
Query: 215 VLAIDHLNEDQLREKAKELWQSIYNLEAEKFDL----QEKFKQQKYE 257
+ E + R++ ++ ++ L+ E+ L +EK ++Q++E
Sbjct: 971 EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017
Score = 56.2 bits (134), Expect = 3e-08
Identities = 65/293 (22%), Positives = 138/293 (47%), Gaps = 56/293 (19%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
+E+ +Y EEE+ + +E+E+ E+ E + E + E+EE + K + E+ +
Sbjct: 1164 QELERQYREEEELQ---QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR 1220
Query: 65 P---------KPRSFMPNLVPPKIPDGER---VDFDDIHRKRMEKDLNELQALIEAHFEN 112
K + N V K + E+ ++ + ++ ++DL L L E +
Sbjct: 1221 SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHL--LGEQQERD 1278
Query: 113 RKKE------------EEELVSLKDRIERRRAER---AEQQRIRNEREKERQNRLAEERA 157
R++E EEE + +++ E +R +R E+Q +R ERE++R+ + + +
Sbjct: 1279 REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKF 1338
Query: 158 R--------REEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKIL 209
R REE+ RR+ D +++ L + ++++ +R +RQ E+++K L
Sbjct: 1339 REEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL--RRQ---ERERKFL 1393
Query: 210 AERRKVLAIDHLNEDQLRE----KAKELWQSIYNLEAEKFDLQEKFKQQKYEI 258
E +++ + E QLR+ K +E Q + E ++ KF++++ ++
Sbjct: 1394 KEEQQLRCQE--REQQLRQDRDRKFREEEQQLSRQERDR-----KFREEEQQV 1439
Score = 56.2 bits (134), Expect = 3e-08
Identities = 56/275 (20%), Positives = 128/275 (46%), Gaps = 29/275 (10%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
+EE + + ++ Q + EEQ+ +E + + + + E+E+ + +E + +E
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE- 1576
Query: 64 KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSL 123
+ R F + + ER +D + R ++ +L+ + F +E+E+L+
Sbjct: 1577 --RDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF----REDEQLLQE 1630
Query: 124 KDRIERRRAER-----AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKAL 178
++ + R ER E+ ++R + E+E+Q R +R REEE+ ++ E++ +++
Sbjct: 1631 REEQQLHRQERDRKFLEEEPQLRRQ-EREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER 1689
Query: 179 SNMMHFGGYIQKTERKSGKRQTEREKKKKILAE----RRKVLAIDHLNEDQLREKAKELW 234
R+ ++ +E+++K L E RR+ L E+QLR++ ++
Sbjct: 1690 DRKF----------REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ-- 1737
Query: 235 QSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQ 269
+ + E + L+E+ + + E LR + D +
Sbjct: 1738 EQLRRQERYRKILEEEQLRPEREEQQLRRQERDRK 1772
Score = 53.9 bits (128), Expect = 2e-07
Identities = 69/304 (22%), Positives = 132/304 (43%), Gaps = 65/304 (21%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEE-----------DAEAEAETEET------------ 41
+ + E+EEE +E+ EE++E A E E+EA+ ++
Sbjct: 670 QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQ 729
Query: 42 -RAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEK--D 98
R +E EE+ +E+E EE + + + + + R+R+
Sbjct: 730 RRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP 789
Query: 99 LNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAE--------------QQRIRNER 144
L E Q + E R++ E+ + ++ E+RR +R E Q+R R ++
Sbjct: 790 LRE-QRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQ 848
Query: 145 EKERQNRLAEERARREEEENRRKAE-----DEARK--------KKALSNMMHFGGYIQKT 191
+E ++ L E++ RR +E RR + +E RK K AL + + +
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQE 908
Query: 192 ERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKF 251
E + +R+ EREK+++ ER+ + E+QL+++ ++L + E EK QE+
Sbjct: 909 EEEELQRE-EREKRRRQEQERQ------YREEEQLQQEEEQLLRE----EREKRRRQERE 957
Query: 252 KQQK 255
+Q +
Sbjct: 958 RQYR 961
Score = 53.5 bits (127), Expect = 2e-07
Identities = 72/296 (24%), Positives = 130/296 (43%), Gaps = 54/296 (18%)
Query: 12 EEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFM 71
EEE +++ EQEE E+ + E E R E++E E+ + E+ E + +S
Sbjct: 582 EEERRQQRLKREQEERLEQRLKRE---EVERLEQEERREQRLKREEPEEERRQQLLKSEE 638
Query: 72 PNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE---EELVSLKDRIE 128
+ E+ + + KR E++ Q L H E R+++E EE ++RI+
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK 698
Query: 129 RR---------------------RAERAEQQRIRNEREKERQNRLAE------ERA-RRE 160
R R + E QR R E+E++R+ R +E ERA R++
Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758
Query: 161 EEENRRK--------AEDEARKKKALSNMMHFGGYIQKTERKSGKRQ---------TERE 203
+EE +R+ E R ++ LS ++ R ++Q E+E
Sbjct: 759 QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKE 818
Query: 204 KKKKILAERRKVLA-IDHLNEDQLREKAKELWQSIYNL--EAEKFDLQEKFKQQKY 256
++++ ER K L ++ + Q RE+A++L + L + E+ QE+ + QK+
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874
Score = 53.1 bits (126), Expect = 3e-07
Identities = 46/203 (22%), Positives = 91/203 (44%), Gaps = 13/203 (6%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
+E+ ++ EEEQ E+++ +E E E+ R E +E++ +E + EE +
Sbjct: 1719 QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ L + D + + + + ++R E+ L Q + + + EEE + L+
Sbjct: 1779 LRQEREEQQLRSQE-SDRKFREEEQLRQEREEQQLRPQQR------DGKYRWEEEQLQLE 1831
Query: 125 DRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRK------AEDEARKKKAL 178
++ +R R ER Q R + + ++R E+ +EEE+ RR+ E+ R+++
Sbjct: 1832 EQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKE 1891
Query: 179 SNMMHFGGYIQKTERKSGKRQTE 201
G I+ E K R E
Sbjct: 1892 EQRHRQVGEIKSQEGKGHGRLLE 1914
Score = 52.0 bits (123), Expect = 6e-07
Identities = 58/249 (23%), Positives = 116/249 (46%), Gaps = 43/249 (17%)
Query: 16 QEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEE-EAKEAEDGPMEESKPKPRSFMPNL 74
Q+ E+Q D + E E + R ++ +E+E E E E+ ++ + + R
Sbjct: 111 QDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQR------ 164
Query: 75 VPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE------EELVSLKDRIE 128
D +R D +++ R+R E E + E ++ K E EE + ++ +E
Sbjct: 165 ------DRQRRD-EELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLE 217
Query: 129 -RRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGY 187
RR+ +QQ + +ERQ+R+ +E EEE+ RK E RK++
Sbjct: 218 LRRKGREEKQQ-----QRRERQDRVFQE----EEEKEWRKRETVLRKEE----------- 257
Query: 188 IQKTERKSGKRQTE-REKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFD 246
+K + + +RQ E +E+++++ R+ L + E+Q +++ + Q E E+ +
Sbjct: 258 -EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERRE 316
Query: 247 LQEKFKQQK 255
QE+ ++Q+
Sbjct: 317 QQEERREQQ 325
Score = 49.7 bits (117), Expect = 3e-06
Identities = 51/227 (22%), Positives = 103/227 (45%), Gaps = 31/227 (13%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAE-AETEETRAEEDEEEEEAKEAEDGPMEESK 64
E ++ +E+E ++E+++ ++ E + E E+ R E ++E+ +E +EE +
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+P L + D + + + + ++R E+ L ++ + + +EEE+L
Sbjct: 1755 LRPEREEQQLRRQE-RDRKFREEEQLRQEREEQQLRSQES------DRKFREEEQL---- 1803
Query: 125 DRIERRRAERAEQQRIRNEREKERQNRLAEE--RARREEEENRRKAEDEARKKKALSNMM 182
R ER + QQR R +E Q +L E+ R R+E + R E A +
Sbjct: 1804 -RQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQ-------- 1854
Query: 183 HFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREK 229
+K+ R+ + E E+K++ ER + L +H+ Q E+
Sbjct: 1855 ------EKSRREEQELWQEEEQKRR--QERERKLREEHIRRQQKEEQ 1893
Score = 39.3 bits (90), Expect = 0.004
Identities = 39/173 (22%), Positives = 79/173 (45%), Gaps = 28/173 (16%)
Query: 82 GERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRI------ERRRAERA 135
G+ D+ R R + + LQ + R++E++ +DR +RRR +R
Sbjct: 90 GQATGLDEEKRARCDGKESLLQ-------DRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQ 142
Query: 136 EQQR--IRNEREKERQNRLAEERARREEEEN--RRKAEDEARKKKALSNMMHFGGYIQKT 191
EQ+R E + E+Q RL E+R R+ +E R++ E + R+++ ++
Sbjct: 143 EQERELAEGEEQSEKQERL-EQRDRQRRDEELWRQRQEWQEREERR----------AEEE 191
Query: 192 ERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEK 244
+ +S K E + RR++L + ++ +++ +E ++ E EK
Sbjct: 192 QLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEK 244
Score = 35.0 bits (79), Expect = 0.075
Identities = 29/153 (18%), Positives = 73/153 (47%), Gaps = 13/153 (8%)
Query: 128 ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGY 187
E+R ++ +++ R++E Q R + EEE +R+ + +++ L+
Sbjct: 98 EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGE----- 152
Query: 188 IQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDL 247
+++E++ Q +R+++ + L +R+ E + R +E QS E E+F
Sbjct: 153 -EQSEKQERLEQRDRQRRDEELWRQRQ-----EWQEREERRAEEEQLQSCKGHETEEFPD 206
Query: 248 QEKFKQQKYEINVLRNRINDNQKVSKTRGKAKV 280
+E+ +++ E+ LR + + ++ + + +V
Sbjct: 207 EEQLRRR--ELLELRRKGREEKQQQRRERQDRV 237
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 72.4 bits (176), Expect = 4e-13
Identities = 62/258 (24%), Positives = 119/258 (46%), Gaps = 32/258 (12%)
Query: 23 EQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDG 82
++E E + E E E R +E+++ K+ E G E K K R +
Sbjct: 37 KKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKER------------EK 84
Query: 83 ERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQQRIRN 142
+R + + R++ +K+ + + E +KK+E + ++R ++R ER ++R +
Sbjct: 85 QRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKE---RERENKQRRERKRKKRRKK 141
Query: 143 EREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTER 202
+R KER+ +ER +RE + +RK E+ R+KK N ++ ER+ K++ ++
Sbjct: 142 KRRKERKRE--KERGKRERKRKKRKKEE--REKKRERNRKERKKERERKERRERKKERKK 197
Query: 203 EKKKKILAERRKVLAIDHLNEDQ----LREKAKE-------LWQSIYNLEAEKFDLQEKF 251
E++KK ER+K D + Q LRE A I++ + F ++
Sbjct: 198 ERRKK--KERKKDRKTDRQTDSQVFRPLRESAFNRVTVTGVFRYRIFHTGLDHFPIKTNI 255
Query: 252 KQQKYEINVLRNRINDNQ 269
++E+N +ND +
Sbjct: 256 LLSRHEVNDGEIEVNDGE 273
Score = 60.8 bits (146), Expect = 1e-09
Identities = 48/183 (26%), Positives = 91/183 (49%), Gaps = 26/183 (14%)
Query: 107 EAHFENRKKEEEELVSLKDRIERRRAERA-EQQRIRNEREKERQNRLAEERARREEEENR 165
E R+KE + K++ +R++ ER E++R R EREK+R+ R +ER +R++E+ +
Sbjct: 44 EKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKK 103
Query: 166 RKAEDEARKKKALSNMMHFGGYIQKTERK----SGKRQTEREKKKKILAERRKVLAID-- 219
R+ + R+++ +K ERK K++ ER++KK+ +RRK +
Sbjct: 104 RERKQRGRRERK-----------KKKERKERERENKQRRERKRKKRRKKKRRKERKREKE 152
Query: 220 --------HLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKV 271
+ + REK +E + E E+ + +E+ K++K E + R D +
Sbjct: 153 RGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTD 212
Query: 272 SKT 274
+T
Sbjct: 213 RQT 215
Score = 47.8 bits (112), Expect = 1e-05
Identities = 29/158 (18%), Positives = 74/158 (46%), Gaps = 11/158 (6%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPR 68
+E ++ ++ E E + + E + + + E+ R + +E+++ + + G E K K R
Sbjct: 61 KEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKER 120
Query: 69 SFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIE 128
+ ER + RKR ++ + + + E K+E + K+ E
Sbjct: 121 K-----------ERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEERE 169
Query: 129 RRRAERAEQQRIRNEREKERQNRLAEERARREEEENRR 166
++R ++++ ER++ R+ + ++ RR+++E ++
Sbjct: 170 KKRERNRKERKKERERKERRERKKERKKERRKKKERKK 207
Score = 40.8 bits (94), Expect = 0.001
Identities = 32/145 (22%), Positives = 65/145 (44%), Gaps = 1/145 (0%)
Query: 139 RIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKR 198
++ E + + +++ +RE E + + E E RK++ G +K +RK +R
Sbjct: 12 KLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRER 71
Query: 199 QTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEI 258
ERE+K+K ++RK + + +K +E Q +K + +E+ ++ K
Sbjct: 72 GKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRR 131
Query: 259 NVLRNRINDNQKVSKTRGKAKVTGR 283
R + +K K R + K G+
Sbjct: 132 ERKRKK-RRKKKRRKERKREKERGK 155
Score = 40.4 bits (93), Expect = 0.002
Identities = 40/148 (27%), Positives = 72/148 (48%), Gaps = 15/148 (10%)
Query: 142 NEREKERQNRLAEERARREEEENRR---KAEDEARKKKALSNMMHFGGYIQKTERKSGKR 198
+ER+KER+ R E+R R E+E +R K E + RKK+ ++ ERK +R
Sbjct: 34 SERKKERRER--EKRKREREKERKRERGKKEKKKRKKRERG---------KERERKRKER 82
Query: 199 QTER-EKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYE 257
+ +R E+++K +R+K + RE+ K+ + E ++ +++ K++K +
Sbjct: 83 EKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKK 142
Query: 258 INVLRNRINDNQKVSKTRGKAKVTGRWK 285
R R + K + R K K R K
Sbjct: 143 RRKERKREKERGKRERKRKKRKKEEREK 170
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 72.0 bits (175), Expect = 6e-13
Identities = 62/276 (22%), Positives = 139/276 (50%), Gaps = 25/276 (9%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEED----EEEEEAKEAEDGP 59
I+E E+ +E+E++ + EQEE E E EE ++ E+EE+ +E E+
Sbjct: 297 IQEREEKIQEQEEK---IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 353
Query: 60 MEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE 119
E+ K + + KI + E+ + R E+ + E + I E +++EE+
Sbjct: 354 HEQEKIREQE-EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEK 412
Query: 120 LVSLKDRI---ERRRAERAEQQRIRNEREKERQNRLAEERAR-REEEENRRKAEDEARKK 175
+ ++++ E E+ E+ R + E+ +E++ ++ E+ + RE+EE ++ E++ ++
Sbjct: 413 MGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQ 472
Query: 176 KALSNMMHFGGYIQKTERKSGKRQTE--REKKKKILAERRKVLAIDHLNEDQLREKAKEL 233
+ M +Q+ E K +RQ E RE++KKI + K+ E+ ++E+ +++
Sbjct: 473 E--GKMCEQEAKMQEQEEKM-RRQEEKIREQEKKIREQEEKI----REQEEMMQEQEEKM 525
Query: 234 WQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQ 269
W+ E + + +EK ++Q+ ++ ++ + +
Sbjct: 526 WEQ----EEKMCEQEEKMQEQEEKMRRQEEKMREQE 557
Score = 65.9 bits (159), Expect = 4e-11
Identities = 51/234 (21%), Positives = 116/234 (49%), Gaps = 30/234 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE--EEEEAKEAEDGPMEE 62
+E + E EE+ QEE + EQE+ E++A+ + E+ R +E++ E+EE + ++ M E
Sbjct: 356 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGE 415
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ K E + + +R E+ + E + I E +++EE +
Sbjct: 416 QEEK-----------MWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 464
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
++++ + + EQ+ E+E++ + +E RE+E+ R+ E++ R+++ +
Sbjct: 465 QEEKMGEQEGKMCEQEAKMQEQEEKMRR---QEEKIREQEKKIREQEEKIREQEEM---- 517
Query: 183 HFGGYIQKTERKSGKRQTER-EKKKKILAERRKVLAIDHLNEDQLREKAKELWQ 235
+Q+ E K +++ + E+++K+ + K+ E+++RE+ L Q
Sbjct: 518 -----MQEQEEKMWEQEEKMCEQEEKMQEQEEKM----RRQEEKMREQEVRLRQ 562
Score = 59.3 bits (142), Expect = 4e-09
Identities = 60/258 (23%), Positives = 123/258 (47%), Gaps = 34/258 (13%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
+Q+E + QEE +E E E EE + E+EE ++ M E + K R
Sbjct: 284 QQQEEKMWRQEEKIQEREEKIQEQEE----KIREQEEKMRRQEEMMWEKEEKMRR----- 334
Query: 75 VPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAER 134
E + + + +E+ ++E + + E E +++EEE++ + R E+
Sbjct: 335 ------QEEMMWEKEEKIRELEEKMHEQEKIREQ--EEKRQEEEKIREQEKRQEQEAKMW 386
Query: 135 AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERK 194
++++IR + EK R+ +E +E+EE + E++ +++ +Q+ E K
Sbjct: 387 RQEEKIREQEEKIRE----QEEMMQEQEEKMGEQEEKMWEQEE---------EMQEQEEK 433
Query: 195 SGKRQTE--REKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFK 252
+RQ E RE++KKI + K+ + + ++Q EK E + EA+ + +EK +
Sbjct: 434 M-RRQEEKIREQEKKIREQEEKIREQEEMMQEQ-EEKMGEQEGKMCEQEAKMQEQEEKMR 491
Query: 253 QQKYEINVLRNRINDNQK 270
+Q+ +I +I + ++
Sbjct: 492 RQEEKIREQEKKIREQEE 509
Score = 51.2 bits (121), Expect = 1e-06
Identities = 38/154 (24%), Positives = 80/154 (51%), Gaps = 6/154 (3%)
Query: 1 MSDIEEVVEEYEEE--EQEEAAVEEQEEAAEEDAEAEAETEETRAEED--EEEEEAKEAE 56
M + EE + E EEE EQEE ++E+ E++ + + E+ R +E+ +E+EE +
Sbjct: 413 MGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQ 472
Query: 57 DGPM--EESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRK 114
+G M +E+K + + KI + E+ + + R ++++ + Q E +
Sbjct: 473 EGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 532
Query: 115 KEEEELVSLKDRIERRRAERAEQQRIRNEREKER 148
E+EE + ++ RR+ E+ +Q +R +++E+
Sbjct: 533 CEQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEK 566
Score = 42.0 bits (97), Expect = 6e-04
Identities = 61/305 (20%), Positives = 130/305 (42%), Gaps = 47/305 (15%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEA------------KEAED----- 57
E E+ A + +EA + EA+ +T + E + A EA D
Sbjct: 96 EDEQKASHQHQEALRRELEAQVQTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRL 155
Query: 58 -------GPMEES-------KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQ 103
G +E++ K K ++ L + + + + +++L E
Sbjct: 156 HDSWKFAGELEQALSAVATQKKKADRYIEELTKER----DALSLELYRNTITDEELKEKN 211
Query: 104 ALIEAHFENRKKEEEELVSLKDRIERRRAERAE----QQRIRNERE---KERQNRLAEER 156
A ++ + + E+ E + L + +R+ ERA+ QQ+++ E + KE Q+ A+ +
Sbjct: 212 AKLQEKLQLVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQ 270
Query: 157 ARREEEE--NRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRK 214
A+ EE E NR + E + + + IQ+ E K +++ + ++++++ E+ +
Sbjct: 271 AQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEE 330
Query: 215 VLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKT 274
+ + EK +EL + ++ E EK QE+ +Q++ +I R K+ +
Sbjct: 331 KMRRQEEMMWEKEEKIRELEEKMH--EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ 388
Query: 275 RGKAK 279
K +
Sbjct: 389 EEKIR 393
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 71.6 bits (174), Expect = 7e-13
Identities = 60/257 (23%), Positives = 131/257 (50%), Gaps = 23/257 (8%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEED---EEEEEAKEAEDGPME 61
+E + E EE+ QEE + EQE+ E++A+ + E+ R +E+ E+EE+ E+ E
Sbjct: 450 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE 509
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
+ K + + + + ++I R++ + ++E + I E ++EE++
Sbjct: 510 QEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK--EKIHEQEEKIRKQEEKMWRQEEKMH 567
Query: 122 SLKDRI-ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
+++I E+ ++++IR + EK R+ EE+ R +EE + + E +++ +
Sbjct: 568 DQEEKIREQEEKVWRQEEKIREQEEKIREQ---EEKIREQEEMTQEQEEKMGEQEEKMCE 624
Query: 181 MMHFGGYIQKTERKSGKRQTE--REKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIY 238
+Q+ E K +RQ E RE++KKI + K+ E+ ++E+ +++W+
Sbjct: 625 QEE---KMQEQEEKM-RRQEEKIREQEKKIREQEEKI----REQEEMMQEQEEKMWEQ-- 674
Query: 239 NLEAEKFDLQEKFKQQK 255
E + + +EK ++Q+
Sbjct: 675 --EEKMCEQEEKMQEQE 689
Score = 66.2 bits (160), Expect = 3e-11
Identities = 60/271 (22%), Positives = 127/271 (46%), Gaps = 50/271 (18%)
Query: 5 EEVVEEYEEEEQE-EAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
EE ++E+EE+ QE E + EQEE E E EE E++E+ +E M E
Sbjct: 367 EEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM----MWEK 422
Query: 64 KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSL 123
+ K R R E+ + E E + +E EE +
Sbjct: 423 EEKMR-------------------------RQEEMMWEK--------EEKIRELEEKMHE 449
Query: 124 KDRIERRRAERAEQQRIRNEREKERQNRLA---EERARREEEENRRKAEDEARKKKALSN 180
+++I + +R E+++IR + +++ Q EE+ R +EE+ R + E R+++ +
Sbjct: 450 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHE 509
Query: 181 MMHFGGYIQKTERKSGKRQTER-EKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYN 239
++ E++ RQ E+ ++++I ++ K+ H E+++R++ +++W+
Sbjct: 510 QEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKI----HEQEEKIRKQEEKMWRQ--- 562
Query: 240 LEAEKFDLQEKFKQQKYEINVLRNRINDNQK 270
E + D +EK ++Q+ ++ +I + ++
Sbjct: 563 -EEKMHDQEEKIREQEEKVWRQEEKIREQEE 592
Score = 56.2 bits (134), Expect = 3e-08
Identities = 54/272 (19%), Positives = 130/272 (47%), Gaps = 24/272 (8%)
Query: 25 EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGER 84
EE E++A+ + + + +E+ E + KE ++ + + +P D
Sbjct: 278 EELKEKNAKLQEKLQLVESEKSEIQLNVKE-----LKRKLERAKLLLPQQQLQAEADHLG 332
Query: 85 VDFDDIHRK-RMEKDLNEL-QALIEAHFENRKKEEEELVSLKDRIERRRAE-RAEQQRIR 141
+ + K + + + NEL L + E ++EE++ +++I+ + + R ++++IR
Sbjct: 333 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 392
Query: 142 NEREKERQNRLA----EERARREEE------ENRRKAED----EARKKKALSNMMHFGGY 187
+ EK R+ EE+ RR+EE E R+ E+ + K + L MH
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 452
Query: 188 IQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNE--DQLREKAKELWQSIYNLEAEKF 245
I++ E K + + RE++K+ E + + + E +++RE+ +++W+ + ++
Sbjct: 453 IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEK 512
Query: 246 DLQEKFKQQKYEINVLRNRINDNQKVSKTRGK 277
+E+ +Q++ E+ +I + +++ + + K
Sbjct: 513 IREEEKRQEQEEMWRQEEKIREQEEIWRQKEK 544
Score = 55.8 bits (133), Expect = 4e-08
Identities = 41/172 (23%), Positives = 84/172 (48%), Gaps = 19/172 (11%)
Query: 1 MSDIEEVVEEYEEEE-QEEAAVEEQEEAAEEDAEAEAETEETRAEEDE---EEEEAKEAE 56
M D EE + E EE+ ++E + EQEE E E E EE E++E E+EE +
Sbjct: 566 MHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQ 625
Query: 57 DGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKE 116
+ M+E + K R E++ + + E+ + E + +++ E ++
Sbjct: 626 EEKMQEQEEKMRR-----------QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 674
Query: 117 EEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKA 168
EE++ +++++ E+ E+ R + E+ E++ RL ++ + +E + +A
Sbjct: 675 EEKMCEQEEKMQ----EQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 722
Score = 49.3 bits (116), Expect = 4e-06
Identities = 36/178 (20%), Positives = 88/178 (49%), Gaps = 17/178 (9%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE---EEEEAKEAEDGPME 61
EE + E EE +++ + EQEE + E EE +++E E+EE ++ +
Sbjct: 529 EEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIR 588
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
E + K R E++ + + E+ + E + + E +++EE++
Sbjct: 589 EQEEKIRE-----------QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMR 637
Query: 122 SLKDRI-ERRRAERAEQQRIRNERE--KERQNRLAEERARREEEENRRKAEDEARKKK 176
+++I E+ + R ++++IR + E +E++ ++ E+ + E+E + + ++E +++
Sbjct: 638 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 695
Score = 48.9 bits (115), Expect = 5e-06
Identities = 34/172 (19%), Positives = 81/172 (47%), Gaps = 7/172 (4%)
Query: 5 EEVVEEYEEE--EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
EE + + EE+ QEE +++E+ E++ + + E+ R E EE+ +E + EE
Sbjct: 549 EEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIR--EQEEKIREQEEKIREQEE 606
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ M E++ + +R E+ + E + I E +++EE +
Sbjct: 607 MTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQE 666
Query: 123 LKDRI---ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDE 171
++++ E + E+ E+ + + E+ + ++ ++ E+ R ++E + + E
Sbjct: 667 QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718
Score = 30.8 bits (68), Expect = 1.4
Identities = 26/143 (18%), Positives = 66/143 (46%), Gaps = 12/143 (8%)
Query: 128 ERRRAERAEQQRIRNEREKERQN-------RLAEERARREEEENRRKAEDEARKK-KALS 179
+ ++A Q+ +R E E + + + A + ++ E EAR L
Sbjct: 170 DEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH 229
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAID----HLNEDQLREKAKELWQ 235
+ F G +++ ++ + ++ + L + R L+++ + +++L+EK +L +
Sbjct: 230 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 289
Query: 236 SIYNLEAEKFDLQEKFKQQKYEI 258
+ +E+EK ++Q K+ K ++
Sbjct: 290 KLQLVESEKSEIQLNVKELKRKL 312
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 71.2 bits (173), Expect = 9e-13
Identities = 63/280 (22%), Positives = 120/280 (42%), Gaps = 25/280 (8%)
Query: 10 EYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRS 69
E + E++ + E E + E E ETE R + + E + + + E+ + R+
Sbjct: 192 ERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERA 251
Query: 70 FMPNLVPPKIPDGERVDFDDIHRKRMEKDLN---ELQALIEAHFENRKKEEEELVSLKDR 126
K + ER D R++ E++ + Q E E +K E + ++R
Sbjct: 252 SERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERER 311
Query: 127 IERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGG 186
R+ ER ERE+ER+ + ER R +E E +RK + E +++
Sbjct: 312 ERNRKRER------ERERERERERQRETERDREKERERKRKRQTEMDRER---------- 355
Query: 187 YIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE---LWQSIYNLEAE 243
+ + G+RQ ERE++++ +R+ + D+ R++ KE + + + E
Sbjct: 356 --NRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRE 413
Query: 244 KFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAKVTGR 283
+E+ K ++ E R R + QK + R + + T R
Sbjct: 414 TEKQREREKDRESERGRERGREREKQK-GRERDRERQTDR 452
Score = 60.5 bits (145), Expect = 2e-09
Identities = 60/266 (22%), Positives = 109/266 (40%), Gaps = 31/266 (11%)
Query: 13 EEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEE---EEAKEAEDGPMEESKPKPRS 69
E+E+E E++ E + + E E E+ R E E E E+ + ED E + + R
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERE 215
Query: 70 FMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIER 129
+ +R +R + E + E E K+ E E +DR R
Sbjct: 216 RETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRR 275
Query: 130 -----RRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHF 184
R+ +R Q+R +RE ER+ E + RE E R + + R+++
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKR---ERQRERERERERNRKRERERERE-------- 324
Query: 185 GGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAEK 244
+ +R+TER+++K+ +R++ +D Q + + + E E+
Sbjct: 325 -------RERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERER 377
Query: 245 FDLQEKFKQQKYEINVLRNRINDNQK 270
D Q ++++ E R+R D QK
Sbjct: 378 -DRQSAREREERE----RDRDRDRQK 398
Score = 58.5 bits (140), Expect = 6e-09
Identities = 57/267 (21%), Positives = 112/267 (41%), Gaps = 32/267 (11%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEEDAE--------AEAETEETRAEEDEEEEEAKEAEDGPM 60
E + E+E +E+E E + E + E E R E E E +
Sbjct: 112 ERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQT 171
Query: 61 EESKPKPRSFMPNLVPPKIPDGERV---DFDDIHRKRMEKDLNELQALIEAHFENRKKEE 117
E ++ K R N + + +R +D H +R + E + E + + E
Sbjct: 172 ERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRE 231
Query: 118 EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKA 177
+ +R ++AER ER+KER+ +R R ++ R + D R+++
Sbjct: 232 RDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRT 291
Query: 178 LSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSI 237
+ ++TERK +RQ ERE++++ +R + ++ RE+ +E
Sbjct: 292 ERD--------RETERKR-ERQRERERERERNRKRER-----ERERERERERQRE----- 332
Query: 238 YNLEAEKFDLQEKFKQQKYEINVLRNR 264
E ++ +E+ ++++ E++ RNR
Sbjct: 333 --TERDREKERERKRKRQTEMDRERNR 357
Score = 57.4 bits (137), Expect = 1e-08
Identities = 56/272 (20%), Positives = 107/272 (39%), Gaps = 34/272 (12%)
Query: 12 EEEEQEEAAVEEQEEAAEEDAEAEAETE-ETRAEEDEEEEEAKEAEDGPMEESKPKPRSF 70
+E + + ++A +D E + E E R E+ + E E + E+ + + R
Sbjct: 34 QESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKR-- 91
Query: 71 MPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERR 130
D HR+R E + + + ++++E ++R R
Sbjct: 92 ------------------DRHRERQRDREKERERQTDRERDRQREKERNRQKERERETER 133
Query: 131 RAERAEQQRIRNEREKERQNRLAEERAR-------REEEENRRKAEDEARKKKALSNMMH 183
ER ++ +RE+ERQ +ER R R+ E NR+K + + ++
Sbjct: 134 EGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERER 193
Query: 184 FGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAE 243
KTE + +R ERE++++ E + D D+ R+ +E +AE
Sbjct: 194 QREKENKTEDRHSERGRERERERETETETERKRQTDR-ERDRQRKTERE-----REKQAE 247
Query: 244 KFDLQEKFKQQKYEINVLRNRINDNQKVSKTR 275
+ E+ ++ E R+R D + K R
Sbjct: 248 RERASERETERDKERERERDRDRDRDRRQKER 279
Score = 55.5 bits (132), Expect = 5e-08
Identities = 46/210 (21%), Positives = 86/210 (40%), Gaps = 19/210 (9%)
Query: 13 EEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMP 72
++E+E +++ E D E E + E R E E E K + E + + R
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQR---- 331
Query: 73 NLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRA 132
+ ER + RKR + + + + E R++ E E ER R
Sbjct: 332 --------ETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERER-------ERERE 376
Query: 133 ERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTE 192
+ R R ERE++R +ER R+ E++ + E E ++++ G +
Sbjct: 377 RDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRER 436
Query: 193 RKSGKRQTEREKKKKILAERRKVLAIDHLN 222
K R+ +RE++ A R++ + ++N
Sbjct: 437 EKQKGRERDRERQTDRQAGRQRKRSTLYVN 466
Score = 52.0 bits (123), Expect = 6e-07
Identities = 43/214 (20%), Positives = 94/214 (43%), Gaps = 10/214 (4%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAE---DGPME 61
E E +E E+E +++ +E + R E D E E +E + + E
Sbjct: 253 ERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERE 312
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
++ + R + + ER + RKR + + + + E R++ E E
Sbjct: 313 RNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERE 372
Query: 122 SLKDRIERRRAERAEQQRIRN-EREKERQNRLAEERARREEEENRRKAEDEARKKKALSN 180
++R + ER E++R R+ +R+KER+ + ++R + E E +R+ E + ++
Sbjct: 373 RERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRER 432
Query: 181 MMHFGGYIQKTERKSGKRQTEREKKKKILAERRK 214
++ ++K +R ER+ ++ +R++
Sbjct: 433 GR------EREKQKGRERDRERQTDRQAGRQRKR 460
Score = 51.2 bits (121), Expect = 1e-06
Identities = 45/204 (22%), Positives = 88/204 (43%), Gaps = 26/204 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
E+ E E+E +E+E + D + + +E + D + + E D E +
Sbjct: 243 EKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE-RDRETERKR 301
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ R + + ER R+R + E + E E ++K + E+ +
Sbjct: 302 ERQRERERERERNRKRERER------ERERERERQRETERDREKERERKRKRQTEMDRER 355
Query: 125 DRIERRRAER-AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMH 183
+R R R AE++R ERE+ER + A ER RE + +R + ++ R
Sbjct: 356 NRQTGREGRRQAERER---ERERERDRQSAREREERERDRDRDRQKERER---------- 402
Query: 184 FGGYIQKTERKSGKRQTEREKKKK 207
Q + + G+R+TE++++++
Sbjct: 403 -----QTEKDRDGQRETEKQRERE 421
Score = 44.3 bits (103), Expect = 1e-04
Identities = 38/169 (22%), Positives = 70/169 (41%), Gaps = 17/169 (10%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+ E E E E+E ++E E + E E E + + E+E E K M+
Sbjct: 296 ETERKRERQRERERERERNRKRER--ERERERERERQRETERDREKERERKRKRQTEMDR 353
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ + + + ER R+R E++ + + +++E E +
Sbjct: 354 ERNRQTGREGRRQAERERERERERDRQSAREREERERDR---------DRDRQKERERQT 404
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDE 171
KDR +R E+ + EREK+R++ ER R E++ R+ + E
Sbjct: 405 EKDRDGQRETEK------QREREKDRESERGRERGREREKQKGRERDRE 447
Score = 35.8 bits (81), Expect = 0.044
Identities = 38/164 (23%), Positives = 70/164 (42%), Gaps = 14/164 (8%)
Query: 132 AERAEQQRIRN-EREKERQNRLAEERARREEEENRRKAEDEARKK---------KALSNM 181
A+ +++R R ERE+ R+ R E R+ E RR+ +D RK+ +
Sbjct: 49 ADGDDRERNRQKERERRREKRQTERETDRKRE--RRREKDRHRKRDRHRERQRDREKERE 106
Query: 182 MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLE 241
+ K RQ ERE++ + ER + D E + + A++ + + E
Sbjct: 107 RQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRE 166
Query: 242 AEKFDLQEKFKQQKYEIN--VLRNRINDNQKVSKTRGKAKVTGR 283
++ + + K+++ E N R R +K +KT + GR
Sbjct: 167 RQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGR 210
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 70.9 bits (172), Expect = 1e-12
Identities = 63/279 (22%), Positives = 138/279 (49%), Gaps = 27/279 (9%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAE--AEAETEETRAEEDEEEEEAKEAEDG 58
M + EE + E EE+ E+ + EQEE +E+ + + + +E A+ +EE+ +E E+
Sbjct: 386 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEE 118
E+ K R KI + E++ ++ KR E++ Q E + E+E
Sbjct: 446 IREQEKKMWRQ------EEKIHEQEKIREEE---KRQEQEEMWRQ-------EEKIHEQE 489
Query: 119 ELVSLKDRI-ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKA 177
E+ K+++ E+ R +++++ + EK R+ +E RE+EE + E++ R+++
Sbjct: 490 EIWRQKEKMHEQEEKIRKQEEKVWRQEEKIRE----QEEKIREQEEKMWRQEEKIREQEE 545
Query: 178 L---SNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELW 234
+ MH I + E++ + +++KI + KV + +Q EK +E
Sbjct: 546 MWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQ-EEKRQEQE 604
Query: 235 QSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSK 273
+ ++ E + + +EK ++Q+ +I +I + +++++
Sbjct: 605 EKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ 643
Score = 66.2 bits (160), Expect = 3e-11
Identities = 60/267 (22%), Positives = 118/267 (44%), Gaps = 63/267 (23%)
Query: 5 EEVVEEYEEEEQE-EAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEES 63
EE ++E+EE+ QE E + EQEE E E EE E++E+ +E M E
Sbjct: 306 EEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM----MWEK 361
Query: 64 KPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSL 123
+ K R R E+ + E + E +++EE +
Sbjct: 362 EEKMR-------------------------RQEEMMWEKE-------EKMRRQEEMMWEK 389
Query: 124 KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMMH 183
+++I + EQ++IR + EK ++ E+ +R+E+E + ++E
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK----------- 438
Query: 184 FGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAE 243
I++ E K RE++KK+ + K+ + + E++ R++ +E+W+ + E
Sbjct: 439 ----IREQEEKI------REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR-----QEE 483
Query: 244 KFDLQEKFKQQKYEINVLRNRINDNQK 270
K QE+ +QK +++ +I ++
Sbjct: 484 KIHEQEEIWRQKEKMHEQEEKIRKQEE 510
Score = 66.2 bits (160), Expect = 3e-11
Identities = 65/290 (22%), Positives = 137/290 (47%), Gaps = 34/290 (11%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDE----------EEEEAKE 54
+E + E EE+ QEE + EQE+ E++A+ + E+ R +E++ +EE+ E
Sbjct: 403 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 462
Query: 55 AEDGPMEESKPKPRSFMPNLVPPKIPDGERV--------DFDDIHRKRMEKDLNELQALI 106
E EE + + KI + E + + ++ RK+ EK + + +
Sbjct: 463 QEKIREEEKRQEQEEMWRQ--EEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIR 520
Query: 107 EAHFENRKKEE-----EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREE 161
E + R++EE EE + ++ + R + EQ++I E +++ Q E++ R+E
Sbjct: 521 EQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQ----EDKMWRQE 576
Query: 162 EENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTE-REKKKKILAERRKVLAIDH 220
E+ R + E R+++ + Q+ E K K++ + RE+++KI + K+ +
Sbjct: 577 EKIREQEEKVWRQEEKIREQEE---KRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEE 633
Query: 221 LNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 270
+Q E +E + + E + + +EK ++Q+ + +I + +K
Sbjct: 634 KIREQ-EEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEK 682
Score = 60.8 bits (146), Expect = 1e-09
Identities = 44/194 (22%), Positives = 102/194 (52%), Gaps = 10/194 (5%)
Query: 94 RMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRA---ERAEQQRIRNER--EKER 148
R E+ + E + I+ E +++EE++ ++++ R+ E+ E+ R + E EKE
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 363
Query: 149 QNRLAEERARREEEENRRKAE---DEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKK 205
+ R EE +EE+ RR+ E ++ K + L MH I++ E K + + RE++
Sbjct: 364 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQE 423
Query: 206 KKILAERRKVLAIDHLNE--DQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRN 263
K+ E + + + E +++RE+ K++W+ + ++ +E+ +Q++ E+
Sbjct: 424 KRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 483
Query: 264 RINDNQKVSKTRGK 277
+I++ +++ + + K
Sbjct: 484 KIHEQEEIWRQKEK 497
Score = 59.3 bits (142), Expect = 4e-09
Identities = 54/248 (21%), Positives = 113/248 (45%), Gaps = 38/248 (15%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + E EE +EE + EQE+ EE+ E E + R EE E+E K +E K
Sbjct: 537 EEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR----QEEK 592
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ + E+ + + E+ + E + I+ E +++EE++ +
Sbjct: 593 IREQE-------------EKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQE 639
Query: 125 DRIERRRAERAEQQRIRNEREKERQNRLAEERARREEE---ENRRKAEDEARKKKALSNM 181
+ + + + EQ+ E+E++ Q + EE R+EE E +K ++ K + M
Sbjct: 640 EMTQEQEEKMGEQEEKMCEQEEKMQEQ--EETMWRQEEKIREQEKKIREQEEKIREQEEM 697
Query: 182 MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLE 241
M Q+ E K +++ + ++++ + E+ E+++R + +++W+ L
Sbjct: 698 M------QEQEEKMWEQEEKMCEQEEKMQEQ----------EEKMRRQEEKMWEQEVRLR 741
Query: 242 AEKFDLQE 249
++ +QE
Sbjct: 742 QQEEKMQE 749
Score = 50.8 bits (120), Expect = 1e-06
Identities = 37/162 (22%), Positives = 78/162 (48%), Gaps = 9/162 (5%)
Query: 4 IEEVVEEYEEEEQ----EEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGP 59
I E E+ +E+E+ +E + EQEE +E E E EE + E EE + +E + G
Sbjct: 593 IREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEE-KIREQEEMTQEQEEKMGE 651
Query: 60 MEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE 119
EE + M E++ + + E+ + E + +++ E ++EE+
Sbjct: 652 QEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK 711
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREE 161
+ +++++ E+ E+ R + E+ E++ RL ++ + +E
Sbjct: 712 MCEQEEKMQ----EQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 35.0 bits (79), Expect = 0.075
Identities = 26/79 (32%), Positives = 38/79 (48%), Gaps = 11/79 (13%)
Query: 1 MSDIEEVVEEYEEEEQE--------EAAVEEQEEAAEEDAEAEAETEETRAEEDE---EE 49
M + EE + E EE+ QE E + EQE+ E E E EE E++E E+
Sbjct: 649 MGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQ 708
Query: 50 EEAKEAEDGPMEESKPKPR 68
EE ++ M+E + K R
Sbjct: 709 EEKMCEQEEKMQEQEEKMR 727
Score = 30.8 bits (68), Expect = 1.4
Identities = 26/143 (18%), Positives = 66/143 (46%), Gaps = 12/143 (8%)
Query: 128 ERRRAERAEQQRIRNEREKERQN-------RLAEERARREEEENRRKAEDEARKK-KALS 179
+ ++A Q+ +R E E + + + A + ++ E EAR L
Sbjct: 109 DEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLISRLH 168
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAID----HLNEDQLREKAKELWQ 235
+ F G +++ ++ + ++ + L + R L+++ + +++L+EK +L +
Sbjct: 169 DSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQE 228
Query: 236 SIYNLEAEKFDLQEKFKQQKYEI 258
+ +E+EK ++Q K+ K ++
Sbjct: 229 KLQLVESEKSEIQLNVKELKRKL 251
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 70.9 bits (172), Expect = 1e-12
Identities = 64/271 (23%), Positives = 132/271 (48%), Gaps = 29/271 (10%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEE--EEEAKEAEDG 58
M + E+ + EE+ QEE + E+E+ E+ E E EE +++E E+E KE +
Sbjct: 432 MQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 491
Query: 59 PMEESKPK--PRSFMPNL------VPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHF 110
+ E K K + M KI D E + + R EK + E + +
Sbjct: 492 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEK-MREQEDQMWEQE 550
Query: 111 ENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAED 170
E + +E+++ ++R+E++ E+ ++ + E+ +E + E+ REEEE R+ E+
Sbjct: 551 EKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE 610
Query: 171 EARKKKALSNMMHFGGYIQKTERKSGKRQTE-REKKKKILAERRKVLAIDH--LNEDQLR 227
+ ++++ +Q+ E K +++ + +E+++K+ + K+ + + +L
Sbjct: 611 KMQEQEE---------KMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 228 EKAKELWQSIYNLEAEKFDLQEKFKQQKYEI 258
E+ ++LW E EK QEK ++Q+ +I
Sbjct: 662 EQKEKLW------EHEKMQEQEKMQEQEEKI 686
Score = 68.2 bits (165), Expect = 8e-12
Identities = 57/269 (21%), Positives = 127/269 (47%), Gaps = 38/269 (14%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEE---EEEAKEAEDGPME 61
E+ + E E+E +E+ + EQEE +E E E EE E++E+ +EE ++ M
Sbjct: 327 EKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMR 386
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIE--AHFENRKKEEEE 119
E + K R ER+ D + E+ + E + + E KK +E+
Sbjct: 387 EQEQKMRD-----------QEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALS 179
+D+ E+ + E ++R + RE+E R EE+ +++EE + E E ++++
Sbjct: 436 EKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR--- 492
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHL--------NEDQLREKAK 231
+ + + K +++ +E+++KI + K+ + + ++++RE+
Sbjct: 493 --------LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQED 544
Query: 232 ELW---QSIYNLEAEKFDLQEKFKQQKYE 257
++W + + + E + +D +E+ +++ E
Sbjct: 545 QMWEQEEKMRDQEQKMWDQEERMEKKTQE 573
Score = 66.2 bits (160), Expect = 3e-11
Identities = 59/286 (20%), Positives = 140/286 (48%), Gaps = 33/286 (11%)
Query: 1 MSDIEEVVEEYEEE--EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDG 58
M + EE ++E EE+ EQEE E++E+ E+ E + + E+ +E+E+ +E E+
Sbjct: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKD------LNELQALIEAHFEN 112
E+ K + ++ K D E++ ++ R+R +K + E + ++ E
Sbjct: 686 IWEQEKMEKKTQEQE---KKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEK 742
Query: 113 RKKEEEELVSLKDRIERRRAERAEQQRIRNEREK-ERQNRLAEERARREEEENRRKAEDE 171
+++EEE+ ++++ + + EQQR+ ++EK ++ E+ E+EE R E++
Sbjct: 743 MQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEK 802
Query: 172 ARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK 231
R ++ E+ G+ + R +++K+ + K+ E+++ + +
Sbjct: 803 MRGQE---------------EKMRGQEEKMRGQEEKMWGQEEKMWG----QEEKMWGQEE 843
Query: 232 ELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGK 277
++W +E + +EK ++Q+ ++ ++ + ++ K RG+
Sbjct: 844 KMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE--KMRGQ 887
Score = 65.5 bits (158), Expect = 5e-11
Identities = 47/258 (18%), Positives = 129/258 (50%), Gaps = 20/258 (7%)
Query: 5 EEVVEEYEEE--EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+E + E E++ EQEE +++++ +++ E +T+E + ++EE+ +E E M E
Sbjct: 536 QEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEER--MRE 593
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ K R + E + + + E+ + E + + E +++EE++
Sbjct: 594 REKKMRE-----------EEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWE 642
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
++++ + + EQQR+ ++EK ++ +E+ + +E+E + +++ KK
Sbjct: 643 QEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKK 702
Query: 183 HFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNL-- 240
+ + E +R+ + ++++++ E+ + + E++++E+ +E+W+ +
Sbjct: 703 TWDQEKMREEESMREREKKMREEEEMMREQEEKM---QEQEEKMQEQEEEMWEQEEKMWE 759
Query: 241 EAEKFDLQEKFKQQKYEI 258
+ EK Q++ +QK ++
Sbjct: 760 QEEKMWEQQRLPEQKEKL 777
Score = 63.9 bits (154), Expect = 2e-10
Identities = 58/262 (22%), Positives = 125/262 (47%), Gaps = 20/262 (7%)
Query: 24 QEEAAEEDAEAEAETEETRAEEDE--EEEEAKEAEDGPMEESKPKPRSFMPNL--VPPKI 79
QEE ++ E + ++ R +E++ +EE ++G M E + K L ++
Sbjct: 271 QEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKEL 330
Query: 80 PDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLKDRI-ERRRAERAEQQ 138
+ E+ + + E+ + E + + E +++EE++ ++R+ E+ + R ++Q
Sbjct: 331 REQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQ 390
Query: 139 RIRNEREK--ERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSG 196
++R++ E+ E+ RL E+ R E+E + ++ R++K + +KT +
Sbjct: 391 KMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQE------KKTRDQEE 444
Query: 197 KRQTE---REKKKKILAE----RRKVLAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQE 249
K Q E RE++KK+ E R + + E+ ++ KE Q + EK QE
Sbjct: 445 KMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE 504
Query: 250 KFKQQKYEINVLRNRINDNQKV 271
K ++Q+ +I +I D +++
Sbjct: 505 KMQEQEEKIWEQEEKIRDQEEM 526
Score = 62.0 bits (149), Expect = 6e-10
Identities = 58/273 (21%), Positives = 136/273 (49%), Gaps = 30/273 (10%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEED-EEEEEAKEAEDGPMEESKPKP 67
+E + EQEE +++ E++ E + +E R +++ E+EE + ++ M E + K
Sbjct: 305 QEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKM 364
Query: 68 RSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEE---ELVSLK 124
R + + ER+ + + E+ + + + + E +++EE E +
Sbjct: 365 REQEEKMWRQE----ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 420
Query: 125 DRIERRRAERAEQQRIRNEREKE----RQNRLAE-ERARREEEENRRKAEDEARKKKALS 179
+++E+ R E+ Q++ + R++E + R+ E E+ REEEE R+ E++ +K++
Sbjct: 421 EQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQE--E 478
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHL--NEDQLREKAKELWQSI 237
NM + E K ++Q E+K+K+ + + + + E+++R++ +E+W
Sbjct: 479 NMW-------EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ-EEMWG-- 528
Query: 238 YNLEAEKFDLQEKFKQQKYEINVLRNRINDNQK 270
+ +K QEK ++Q+ ++ ++ D ++
Sbjct: 529 ---QEKKMWRQEKMREQEDQMWEQEEKMRDQEQ 558
Score = 62.0 bits (149), Expect = 6e-10
Identities = 53/263 (20%), Positives = 122/263 (46%), Gaps = 22/263 (8%)
Query: 9 EEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPR 68
+E + EQE+ +++E E+D + E R +E E+ K E+ M+E + K R
Sbjct: 381 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR 440
Query: 69 SFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEE------LVS 122
K+ + ER+ + + E+ + E + ++ EN ++EE+ L
Sbjct: 441 D-----QEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 495
Query: 123 LKDRIERRRAERAEQQRIRNEREKER--------QNRLAEERARREEEENRRKAEDEAR- 173
K+++ + + ++++I + EK R + ++ + RE+E+ + E++ R
Sbjct: 496 QKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 555
Query: 174 -KKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 232
++K Q+ E+K+ Q E+ ++++ + ER K + + + EK +E
Sbjct: 556 QEQKMWDQEERMEKKTQEQEKKTWD-QEEKMREEERMREREKKMREEEEMMREQEEKMQE 614
Query: 233 LWQSIYNLEAEKFDLQEKFKQQK 255
+ + E + ++ +EK ++Q+
Sbjct: 615 QEEKMQEQEEKMWEQEEKMQEQE 637
Score = 61.6 bits (148), Expect = 8e-10
Identities = 49/272 (18%), Positives = 130/272 (47%), Gaps = 17/272 (6%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAK------- 53
M + +E + E EE +E+ + EQ E E+ + + + ++TR +E++ +EE +
Sbjct: 399 MWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKK 458
Query: 54 -EAEDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFEN 112
E+ M E + K + N+ + + ++ + K E++ + Q E
Sbjct: 459 MREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 518
Query: 113 RKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRL----AEERARREEEENRRKA 168
+ +++EE+ + ++ R+ R ++ ++ + EK R EER ++ +E +K
Sbjct: 519 KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKT 578
Query: 169 EDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLRE 228
D+ K + M +++ E +++ + +++++ + E+ + + E++++E
Sbjct: 579 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKM---WEQEEKMQE 635
Query: 229 KAKELWQSIYNL--EAEKFDLQEKFKQQKYEI 258
+ +++W+ + + EK Q++ +QK ++
Sbjct: 636 QEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKL 667
Score = 59.7 bits (143), Expect = 3e-09
Identities = 61/289 (21%), Positives = 137/289 (47%), Gaps = 43/289 (14%)
Query: 3 DIEEVVEEYEEEEQ---EEAAVEEQEEAAEEDAEAEAETEETRAEED----EEEEEAKEA 55
++ E E E+EEQ +E + EQEE E E EE E++ E+E++ ++
Sbjct: 336 ELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQ 395
Query: 56 EDGPMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKK 115
E+ E+ + ++ + E++ ++ + + R EK + E E + +
Sbjct: 396 EERMWEQDERLREK------EERMREQEKM-WEQVEKMREEKKMQEQ--------EKKTR 440
Query: 116 EEEELVSLKDRI-ERRRAERAEQQRIRNEREKE---------------RQNRLAEERARR 159
++EE + ++RI ER + R E++ +R + EK +Q RL E++ +
Sbjct: 441 DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 500
Query: 160 EEEENRRKAEDEA-RKKKALSNMMHFGGYIQKTERKSGKRQTER---EKKKKILAERRKV 215
E+E ++ E++ +++ + + G +K R+ R+ E E+++K+ + +K+
Sbjct: 501 WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 560
Query: 216 LAIDHLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNR 264
+ E + +E+ K+ W + E+ ++E+ K+ + E ++R +
Sbjct: 561 WDQEERMEKKTQEQEKKTWDQEEKMREEE-RMREREKKMREEEEMMREQ 608
Score = 52.4 bits (124), Expect = 5e-07
Identities = 55/260 (21%), Positives = 120/260 (46%), Gaps = 15/260 (5%)
Query: 24 QEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNLVPPKIPDGE 83
+E E DA + T E+ +++ A+ E P+ ES+ + K+ +
Sbjct: 200 EELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAK 259
Query: 84 ----RVDFDDIHRK--RMEKDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAERAEQ 137
+V + + + R E++L E + I E ++EE L + ++ + + Q
Sbjct: 260 FLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQ 319
Query: 138 QRIRNEREK---ERQNRLAEERARREEEENRRKAEDEARKKKALSNMMHFGGYIQKTERK 194
++ E+EK E++ L E++ RE+EE ++ E++ +++ + Q+ ER
Sbjct: 320 EKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQE-ERL 378
Query: 195 SGKRQTEREKKKKILAERRKVLAIDHL---NEDQLREKAKELWQSIYNL-EAEKFDLQEK 250
+ + RE+++K+ + ++ D E+++RE+ K +W+ + + E +K QEK
Sbjct: 379 WEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEK-MWEQVEKMREEKKMQEQEK 437
Query: 251 FKQQKYEINVLRNRINDNQK 270
+ + E RI + +K
Sbjct: 438 KTRDQEEKMQEEERIREREK 457
Score = 48.1 bits (113), Expect = 9e-06
Identities = 45/181 (24%), Positives = 79/181 (43%), Gaps = 12/181 (6%)
Query: 1 MSDIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEE--EEEAKEAEDG 58
M + E + E ++ +EE + EQEE +E E E EE E++E+ E+E K E
Sbjct: 709 MREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ 768
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR-MEKDLNELQALIEAHFENRKKEE 117
+ E K K KI + E D + R E+ + + + E +E
Sbjct: 769 RLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQE 828
Query: 118 EELVSLKDRI---------ERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKA 168
E++ ++++ + + E Q + RE+E + R EE+ R +EE+ R +
Sbjct: 829 EKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQE 888
Query: 169 E 169
E
Sbjct: 889 E 889
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 70.1 bits (170), Expect = 2e-12
Identities = 69/276 (25%), Positives = 130/276 (47%), Gaps = 28/276 (10%)
Query: 1 MSDIEEVVEEYEEEEQE-----EAAVEEQEEAAEEDAEAEAETE-ETRAEEDEEEEEAKE 54
M + E + E+ EE+E EAA+E+Q + AE A+A+A+ E E + + +EE
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 55 AEDGPMEESKPKPRSFMPNLVPPKIPD-------GERVDFDDIHRKRMEKDLNELQALIE 107
E+ ++ + K RS L + + + + R R+E+++ ++ +E
Sbjct: 1404 REEAAVDAQQQK-RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 108 AHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEE---- 163
A R E EL +L R RAE AE Q+ + + E ER R ++ ++R+ +
Sbjct: 1463 ATERQRGGAEGELQAL-----RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 164 -NRRKAEDEA--RKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDH 220
+R KAE EA K++AL + ++ ER+ + + ER ++ ++ E + A
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577
Query: 221 LNEDQ--LREKAKELWQSIYNLEAEKFDLQEKFKQQ 254
L + EK +L +S+ L+E+ +++
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613
Score = 62.0 bits (149), Expect = 6e-10
Identities = 74/301 (24%), Positives = 130/301 (43%), Gaps = 47/301 (15%)
Query: 14 EEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPN 73
EE + +E+AA + AEAE E A E EAE E+ R +
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRR 1868
Query: 74 LVPPKIPDGERVDFD------DIH------RKRMEKDLNELQALIEAHFENRKKEEEELV 121
L + R++ DI RK + +L + L+E R++ EEE++
Sbjct: 1869 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1928
Query: 122 SLKDRIERRRAERAEQQ----RIRN------------EREKERQNRLA--EERARREEEE 163
+LK E+ A +AE + RIR+ E E RQ +LA EER RRE EE
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
Query: 164 NRRKA----EDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAID 219
+K+ E+ AR++KA +++ ER K + R +++ AE+ +
Sbjct: 1989 RVQKSLAAEEEAARQRKAA---------LEEVERLKAKVEEARRLRER--AEQESARQLQ 2037
Query: 220 HLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAK 279
E + E + ++ ++ +LQ+ +Q++ ++ LR ++ ++ +A+
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 280 V 280
V
Sbjct: 2098 V 2098
Score = 55.8 bits (133), Expect = 4e-08
Identities = 71/273 (26%), Positives = 118/273 (43%), Gaps = 46/273 (16%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETR-AEEDEEEEEAKEAEDGPMEESK 64
E E ++ +E+A Q +AA E EAE E R A+ ++ K+A D ME
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--- 2168
Query: 65 PKPRSFMPNLVPPKIPDGE-------RVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE 117
K + F + K + +++ D + ++++L L+A R + E
Sbjct: 2169 -KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 118 EELVS----------LKDRIERRR-----AERAEQQRIRNEREKERQNRLAEERAR---- 158
EEL S LK RIE ++ QR E E E+ ++AEE AR
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVA 2286
Query: 159 -REEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+E R+ AE++ +++AL+ M E+ ++ R K + L +++K LA
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKM-------LKEKMQAVQEATRLKAEAELLQQQKELA 2339
Query: 218 ID---HLNED--QLREKAKELWQSIY-NLEAEK 244
+ L ED Q+ ++ E Q LEAE+
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372
Score = 51.6 bits (122), Expect = 8e-07
Identities = 61/259 (23%), Positives = 108/259 (41%), Gaps = 32/259 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE E EE+ + ++ +EEAA + A E E +A+ +E + AE + +
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ L + H +++ ELQ ++ +E+ L L+
Sbjct: 2038 LAQEAAQKRLQAE----------EKAHAFAVQQKEQELQQTLQ-------QEQSVLDQLR 2080
Query: 125 DRIE--RRRAERAEQQRIRNEREKERQNRLAEERARRE---EEENRRKAEDEARKKKALS 179
E RR AE AE+ R++ ERE + R EE R + EE+ + +A+ +A +K
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK-ELWQSIY 238
Q+ R++ Q +K+ AE K E LR+KA+ E +
Sbjct: 2141 EAE------QEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTL 2191
Query: 239 NLEAEKFDLQEKFKQQKYE 257
L+ E+ D Q+ ++ +
Sbjct: 2192 RLQLEETDHQKNLLDEELQ 2210
Score = 50.1 bits (118), Expect = 2e-06
Identities = 58/238 (24%), Positives = 102/238 (42%), Gaps = 51/238 (21%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
++E AV + E AE A+ +AE E R E + E E +
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ--------------------- 1635
Query: 75 VPPKIPDGERVDFDDIHRKRME-KDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAE 133
+ ++ R R++ +++ + ++L +A E +K+E E E RR
Sbjct: 1636 ----------LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER--------EARRRG 1677
Query: 134 RAEQQRIRN----EREKERQNRLAE----ERARREEEENRRKAEDEARKKKALSNMMHFG 185
+AE+Q +R E+E E+Q +LAE +R E+E R +AE E +++
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 186 GYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAE 243
++ + KRQ + K+ AE +LA E++ R ++ +S LEAE
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE---KSKQRLEAE 1792
Score = 49.3 bits (116), Expect = 4e-06
Identities = 56/230 (24%), Positives = 96/230 (41%), Gaps = 10/230 (4%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE V + E+ E ++Q EA EAE E E + + +E +AE+ ++S
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657
Query: 65 PKPRSFMPNLVPPKIP--DGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ + + G+ + R+ E++L + + L E + R E+EL+
Sbjct: 1658 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1717
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
L R E+ EQQR E E R R A ++ +E A+ A + L++
Sbjct: 1718 L-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1772
Query: 183 HFGGYIQKTERKSGKRQTEREKKKKILAE---RRKVLAIDHLNEDQLREK 229
+ T KS +R + + LAE R + LA + + QL E+
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Score = 46.6 bits (109), Expect = 2e-05
Identities = 67/276 (24%), Positives = 114/276 (41%), Gaps = 59/276 (21%)
Query: 10 EYEEEEQEEAAVEE-----QEEAA---EEDAEAEAETEETRAEED---EEEEEAKEAEDG 58
E E+ EQ+ +EE Q EAA ++ E EAE + RAE + + A+E
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEE 118
E+SK +R++ + + + ++ L+AL E R+ EE
Sbjct: 1781 TSEKSK------------------QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 119 ELVSLKDRIERRRAER----AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARK 174
+ + ER AE+ E R++ E E +A + E E RR AEDEA +
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAE------IALKEKEAENERLRRLAEDEAFQ 1876
Query: 175 KKALSNM--MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 232
++ L H ++ + +E E++K ++ ED LR++ ++
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-------------EDTLRQR-RQ 1922
Query: 233 LWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDN 268
+ + I L+A EK K E+ + RI N
Sbjct: 1923 VEEEILALKAS----FEKAAAGKAELELELGRIRSN 1954
Score = 43.1 bits (100), Expect = 3e-04
Identities = 47/230 (20%), Positives = 101/230 (43%), Gaps = 29/230 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + + ++ +E + E A ++ +T E + ++ + + E +E K
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRM---EKDLNELQALI--EAHFENRKKEEEE 119
K + L+ K + + V + + ++ + L+E +L+ E E K + E+
Sbjct: 2460 EKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2518
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLA------------EERARREEEENRRK 167
L +D + + + R EQQR + + E+ERQ +A EE RR++EE ++
Sbjct: 2519 L--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Query: 168 AEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ ++++ L+ ++ +R + Q E+ + LA +V A
Sbjct: 2577 EQQRRQQEELLA---------EENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Score = 40.8 bits (94), Expect = 0.001
Identities = 52/221 (23%), Positives = 96/221 (43%), Gaps = 28/221 (12%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+I E + E QE+ + + E + ++ +AE E E E+E + E
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE------ 2465
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR---MEKDLNELQALI--EAHFENRKKEE 117
L+ K + + V + + ++ + L+E +L+ E E K +
Sbjct: 2466 ---------AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 118 EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE-ERARREEEENRRKAEDEARKKK 176
E+L +D + + + R EQQR + + E+ERQ +A E ARR + E AE+ R+K+
Sbjct: 2517 EQL--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQ 2570
Query: 177 ALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ Q+ E + + Q RE+ + + + R LA
Sbjct: 2571 EELQQLE-QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2610
Score = 28.5 bits (62), Expect = 7.0
Identities = 37/174 (21%), Positives = 63/174 (36%), Gaps = 23/174 (13%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
IE+ + E+ Q+E A +Q EE + + E E + A +E EAE+G
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
+ + + + +R +++ + ++ +LQ L E H EE
Sbjct: 2569 KQEELQQL-----------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 122 SL----------KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENR 165
S +D ++ AE + R K RL E EE R
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 70.1 bits (170), Expect = 2e-12
Identities = 69/276 (25%), Positives = 130/276 (47%), Gaps = 28/276 (10%)
Query: 1 MSDIEEVVEEYEEEEQE-----EAAVEEQEEAAEEDAEAEAETE-ETRAEEDEEEEEAKE 54
M + E + E+ EE+E EAA+E+Q + AE A+A+A+ E E + + +EE
Sbjct: 1348 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 55 AEDGPMEESKPKPRSFMPNLVPPKIPD-------GERVDFDDIHRKRMEKDLNELQALIE 107
E+ ++ + K RS L + + + + R R+E+++ ++ +E
Sbjct: 1408 REEAAVDAQQQK-RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1466
Query: 108 AHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEE---- 163
A R E EL +L R RAE AE Q+ + + E ER R ++ ++R+ +
Sbjct: 1467 ATERQRGGAEGELQAL-----RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1521
Query: 164 -NRRKAEDEA--RKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDH 220
+R KAE EA K++AL + ++ ER+ + + ER ++ ++ E + A
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1581
Query: 221 LNEDQ--LREKAKELWQSIYNLEAEKFDLQEKFKQQ 254
L + EK +L +S+ L+E+ +++
Sbjct: 1582 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1617
Score = 62.0 bits (149), Expect = 6e-10
Identities = 74/301 (24%), Positives = 130/301 (43%), Gaps = 47/301 (15%)
Query: 14 EEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPN 73
EE + +E+AA + AEAE E A E EAE E+ R +
Sbjct: 1815 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRR 1872
Query: 74 LVPPKIPDGERVDFD------DIH------RKRMEKDLNELQALIEAHFENRKKEEEELV 121
L + R++ DI RK + +L + L+E R++ EEE++
Sbjct: 1873 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1932
Query: 122 SLKDRIERRRAERAEQQ----RIRN------------EREKERQNRLA--EERARREEEE 163
+LK E+ A +AE + RIR+ E E RQ +LA EER RRE EE
Sbjct: 1933 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1992
Query: 164 NRRKA----EDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAID 219
+K+ E+ AR++KA +++ ER K + R +++ AE+ +
Sbjct: 1993 RVQKSLAAEEEAARQRKAA---------LEEVERLKAKVEEARRLRER--AEQESARQLQ 2041
Query: 220 HLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAK 279
E + E + ++ ++ +LQ+ +Q++ ++ LR ++ ++ +A+
Sbjct: 2042 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2101
Query: 280 V 280
V
Sbjct: 2102 V 2102
Score = 55.8 bits (133), Expect = 4e-08
Identities = 71/273 (26%), Positives = 118/273 (43%), Gaps = 46/273 (16%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETR-AEEDEEEEEAKEAEDGPMEESK 64
E E ++ +E+A Q +AA E EAE E R A+ ++ K+A D ME
Sbjct: 2116 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--- 2172
Query: 65 PKPRSFMPNLVPPKIPDGE-------RVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE 117
K + F + K + +++ D + ++++L L+A R + E
Sbjct: 2173 -KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2231
Query: 118 EELVS----------LKDRIERRR-----AERAEQQRIRNEREKERQNRLAEERAR---- 158
EEL S LK RIE ++ QR E E E+ ++AEE AR
Sbjct: 2232 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVA 2290
Query: 159 -REEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+E R+ AE++ +++AL+ M E+ ++ R K + L +++K LA
Sbjct: 2291 AQEAARLRQLAEEDLAQQRALAEKM-------LKEKMQAVQEATRLKAEAELLQQQKELA 2343
Query: 218 ID---HLNED--QLREKAKELWQSIY-NLEAEK 244
+ L ED Q+ ++ E Q LEAE+
Sbjct: 2344 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2376
Score = 51.6 bits (122), Expect = 8e-07
Identities = 61/259 (23%), Positives = 108/259 (41%), Gaps = 32/259 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE E EE+ + ++ +EEAA + A E E +A+ +E + AE + +
Sbjct: 1982 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2041
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ L + H +++ ELQ ++ +E+ L L+
Sbjct: 2042 LAQEAAQKRLQAE----------EKAHAFAVQQKEQELQQTLQ-------QEQSVLDQLR 2084
Query: 125 DRIE--RRRAERAEQQRIRNEREKERQNRLAEERARRE---EEENRRKAEDEARKKKALS 179
E RR AE AE+ R++ ERE + R EE R + EE+ + +A+ +A +K
Sbjct: 2085 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2144
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK-ELWQSIY 238
Q+ R++ Q +K+ AE K E LR+KA+ E +
Sbjct: 2145 EAE------QEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTL 2195
Query: 239 NLEAEKFDLQEKFKQQKYE 257
L+ E+ D Q+ ++ +
Sbjct: 2196 RLQLEETDHQKNLLDEELQ 2214
Score = 50.1 bits (118), Expect = 2e-06
Identities = 58/238 (24%), Positives = 102/238 (42%), Gaps = 51/238 (21%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
++E AV + E AE A+ +AE E R E + E E +
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ--------------------- 1639
Query: 75 VPPKIPDGERVDFDDIHRKRME-KDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAE 133
+ ++ R R++ +++ + ++L +A E +K+E E E RR
Sbjct: 1640 ----------LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER--------EARRRG 1681
Query: 134 RAEQQRIRN----EREKERQNRLAE----ERARREEEENRRKAEDEARKKKALSNMMHFG 185
+AE+Q +R E+E E+Q +LAE +R E+E R +AE E +++
Sbjct: 1682 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1741
Query: 186 GYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAE 243
++ + KRQ + K+ AE +LA E++ R ++ +S LEAE
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE---KSKQRLEAE 1796
Score = 49.3 bits (116), Expect = 4e-06
Identities = 56/230 (24%), Positives = 96/230 (41%), Gaps = 10/230 (4%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE V + E+ E ++Q EA EAE E E + + +E +AE+ ++S
Sbjct: 1602 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1661
Query: 65 PKPRSFMPNLVPPKIP--DGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ + + G+ + R+ E++L + + L E + R E+EL+
Sbjct: 1662 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1721
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
L R E+ EQQR E E R R A ++ +E A+ A + L++
Sbjct: 1722 L-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1776
Query: 183 HFGGYIQKTERKSGKRQTEREKKKKILAE---RRKVLAIDHLNEDQLREK 229
+ T KS +R + + LAE R + LA + + QL E+
Sbjct: 1777 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826
Score = 46.6 bits (109), Expect = 2e-05
Identities = 67/276 (24%), Positives = 114/276 (41%), Gaps = 59/276 (21%)
Query: 10 EYEEEEQEEAAVEE-----QEEAA---EEDAEAEAETEETRAEED---EEEEEAKEAEDG 58
E E+ EQ+ +EE Q EAA ++ E EAE + RAE + + A+E
Sbjct: 1725 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEE 118
E+SK +R++ + + + ++ L+AL E R+ EE
Sbjct: 1785 TSEKSK------------------QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1826
Query: 119 ELVSLKDRIERRRAER----AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARK 174
+ + ER AE+ E R++ E E +A + E E RR AEDEA +
Sbjct: 1827 DAARQRAEAERVLAEKLAAIGEATRLKTEAE------IALKEKEAENERLRRLAEDEAFQ 1880
Query: 175 KKALSNM--MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 232
++ L H ++ + +E E++K ++ ED LR++ ++
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-------------EDTLRQR-RQ 1926
Query: 233 LWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDN 268
+ + I L+A EK K E+ + RI N
Sbjct: 1927 VEEEILALKAS----FEKAAAGKAELELELGRIRSN 1958
Score = 43.1 bits (100), Expect = 3e-04
Identities = 47/230 (20%), Positives = 101/230 (43%), Gaps = 29/230 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + + ++ +E + E A ++ +T E + ++ + + E +E K
Sbjct: 2404 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2463
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRM---EKDLNELQALI--EAHFENRKKEEEE 119
K + L+ K + + V + + ++ + L+E +L+ E E K + E+
Sbjct: 2464 EKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2522
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLA------------EERARREEEENRRK 167
L +D + + + R EQQR + + E+ERQ +A EE RR++EE ++
Sbjct: 2523 L--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2580
Query: 168 AEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ ++++ L+ ++ +R + Q E+ + LA +V A
Sbjct: 2581 EQQRRQQEELLA---------EENQRLREQLQLLEEQHRAALAHSEEVTA 2621
Score = 40.8 bits (94), Expect = 0.001
Identities = 52/221 (23%), Positives = 96/221 (43%), Gaps = 28/221 (12%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+I E + E QE+ + + E + ++ +AE E E E+E + E
Sbjct: 2416 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE------ 2469
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR---MEKDLNELQALI--EAHFENRKKEE 117
L+ K + + V + + ++ + L+E +L+ E E K +
Sbjct: 2470 ---------AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2520
Query: 118 EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE-ERARREEEENRRKAEDEARKKK 176
E+L +D + + + R EQQR + + E+ERQ +A E ARR + E AE+ R+K+
Sbjct: 2521 EQL--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQ 2574
Query: 177 ALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ Q+ E + + Q RE+ + + + R LA
Sbjct: 2575 EELQQLE-QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2614
Score = 28.5 bits (62), Expect = 7.0
Identities = 37/174 (21%), Positives = 63/174 (36%), Gaps = 23/174 (13%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
IE+ + E+ Q+E A +Q EE + + E E + A +E EAE+G
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2572
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
+ + + + +R +++ + ++ +LQ L E H EE
Sbjct: 2573 KQEELQQL-----------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2621
Query: 122 SL----------KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENR 165
S +D ++ AE + R K RL E EE R
Sbjct: 2622 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2675
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 70.1 bits (170), Expect = 2e-12
Identities = 69/276 (25%), Positives = 130/276 (47%), Gaps = 28/276 (10%)
Query: 1 MSDIEEVVEEYEEEEQE-----EAAVEEQEEAAEEDAEAEAETE-ETRAEEDEEEEEAKE 54
M + E + E+ EE+E EAA+E+Q + AE A+A+A+ E E + + +EE
Sbjct: 1344 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 55 AEDGPMEESKPKPRSFMPNLVPPKIPD-------GERVDFDDIHRKRMEKDLNELQALIE 107
E+ ++ + K RS L + + + + R R+E+++ ++ +E
Sbjct: 1404 REEAAVDAQQQK-RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1462
Query: 108 AHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEE---- 163
A R E EL +L R RAE AE Q+ + + E ER R ++ ++R+ +
Sbjct: 1463 ATERQRGGAEGELQAL-----RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1517
Query: 164 -NRRKAEDEA--RKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDH 220
+R KAE EA K++AL + ++ ER+ + + ER ++ ++ E + A
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1577
Query: 221 LNEDQ--LREKAKELWQSIYNLEAEKFDLQEKFKQQ 254
L + EK +L +S+ L+E+ +++
Sbjct: 1578 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1613
Score = 62.0 bits (149), Expect = 6e-10
Identities = 74/301 (24%), Positives = 130/301 (43%), Gaps = 47/301 (15%)
Query: 14 EEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPN 73
EE + +E+AA + AEAE E A E EAE E+ R +
Sbjct: 1811 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRR 1868
Query: 74 LVPPKIPDGERVDFD------DIH------RKRMEKDLNELQALIEAHFENRKKEEEELV 121
L + R++ DI RK + +L + L+E R++ EEE++
Sbjct: 1869 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1928
Query: 122 SLKDRIERRRAERAEQQ----RIRN------------EREKERQNRLA--EERARREEEE 163
+LK E+ A +AE + RIR+ E E RQ +LA EER RRE EE
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988
Query: 164 NRRKA----EDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAID 219
+K+ E+ AR++KA +++ ER K + R +++ AE+ +
Sbjct: 1989 RVQKSLAAEEEAARQRKAA---------LEEVERLKAKVEEARRLRER--AEQESARQLQ 2037
Query: 220 HLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAK 279
E + E + ++ ++ +LQ+ +Q++ ++ LR ++ ++ +A+
Sbjct: 2038 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2097
Query: 280 V 280
V
Sbjct: 2098 V 2098
Score = 55.8 bits (133), Expect = 4e-08
Identities = 71/273 (26%), Positives = 118/273 (43%), Gaps = 46/273 (16%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETR-AEEDEEEEEAKEAEDGPMEESK 64
E E ++ +E+A Q +AA E EAE E R A+ ++ K+A D ME
Sbjct: 2112 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--- 2168
Query: 65 PKPRSFMPNLVPPKIPDGE-------RVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE 117
K + F + K + +++ D + ++++L L+A R + E
Sbjct: 2169 -KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 118 EELVS----------LKDRIERRR-----AERAEQQRIRNEREKERQNRLAEERAR---- 158
EEL S LK RIE ++ QR E E E+ ++AEE AR
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVA 2286
Query: 159 -REEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+E R+ AE++ +++AL+ M E+ ++ R K + L +++K LA
Sbjct: 2287 AQEAARLRQLAEEDLAQQRALAEKM-------LKEKMQAVQEATRLKAEAELLQQQKELA 2339
Query: 218 ID---HLNED--QLREKAKELWQSIY-NLEAEK 244
+ L ED Q+ ++ E Q LEAE+
Sbjct: 2340 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2372
Score = 51.6 bits (122), Expect = 8e-07
Identities = 61/259 (23%), Positives = 108/259 (41%), Gaps = 32/259 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE E EE+ + ++ +EEAA + A E E +A+ +E + AE + +
Sbjct: 1978 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2037
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ L + H +++ ELQ ++ +E+ L L+
Sbjct: 2038 LAQEAAQKRLQAE----------EKAHAFAVQQKEQELQQTLQ-------QEQSVLDQLR 2080
Query: 125 DRIE--RRRAERAEQQRIRNEREKERQNRLAEERARRE---EEENRRKAEDEARKKKALS 179
E RR AE AE+ R++ ERE + R EE R + EE+ + +A+ +A +K
Sbjct: 2081 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK-ELWQSIY 238
Q+ R++ Q +K+ AE K E LR+KA+ E +
Sbjct: 2141 EAE------QEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTL 2191
Query: 239 NLEAEKFDLQEKFKQQKYE 257
L+ E+ D Q+ ++ +
Sbjct: 2192 RLQLEETDHQKNLLDEELQ 2210
Score = 50.1 bits (118), Expect = 2e-06
Identities = 58/238 (24%), Positives = 102/238 (42%), Gaps = 51/238 (21%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
++E AV + E AE A+ +AE E R E + E E +
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ--------------------- 1635
Query: 75 VPPKIPDGERVDFDDIHRKRME-KDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAE 133
+ ++ R R++ +++ + ++L +A E +K+E E E RR
Sbjct: 1636 ----------LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER--------EARRRG 1677
Query: 134 RAEQQRIRN----EREKERQNRLAE----ERARREEEENRRKAEDEARKKKALSNMMHFG 185
+AE+Q +R E+E E+Q +LAE +R E+E R +AE E +++
Sbjct: 1678 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1737
Query: 186 GYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAE 243
++ + KRQ + K+ AE +LA E++ R ++ +S LEAE
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE---KSKQRLEAE 1792
Score = 49.3 bits (116), Expect = 4e-06
Identities = 56/230 (24%), Positives = 96/230 (41%), Gaps = 10/230 (4%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE V + E+ E ++Q EA EAE E E + + +E +AE+ ++S
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657
Query: 65 PKPRSFMPNLVPPKIP--DGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ + + G+ + R+ E++L + + L E + R E+EL+
Sbjct: 1658 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1717
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
L R E+ EQQR E E R R A ++ +E A+ A + L++
Sbjct: 1718 L-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1772
Query: 183 HFGGYIQKTERKSGKRQTEREKKKKILAE---RRKVLAIDHLNEDQLREK 229
+ T KS +R + + LAE R + LA + + QL E+
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Score = 46.6 bits (109), Expect = 2e-05
Identities = 67/276 (24%), Positives = 114/276 (41%), Gaps = 59/276 (21%)
Query: 10 EYEEEEQEEAAVEE-----QEEAA---EEDAEAEAETEETRAEED---EEEEEAKEAEDG 58
E E+ EQ+ +EE Q EAA ++ E EAE + RAE + + A+E
Sbjct: 1721 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEE 118
E+SK +R++ + + + ++ L+AL E R+ EE
Sbjct: 1781 TSEKSK------------------QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1822
Query: 119 ELVSLKDRIERRRAER----AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARK 174
+ + ER AE+ E R++ E E +A + E E RR AEDEA +
Sbjct: 1823 DAARQRAEAERVLAEKLAAIGEATRLKTEAE------IALKEKEAENERLRRLAEDEAFQ 1876
Query: 175 KKALSNM--MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 232
++ L H ++ + +E E++K ++ ED LR++ ++
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-------------EDTLRQR-RQ 1922
Query: 233 LWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDN 268
+ + I L+A EK K E+ + RI N
Sbjct: 1923 VEEEILALKAS----FEKAAAGKAELELELGRIRSN 1954
Score = 43.1 bits (100), Expect = 3e-04
Identities = 47/230 (20%), Positives = 101/230 (43%), Gaps = 29/230 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + + ++ +E + E A ++ +T E + ++ + + E +E K
Sbjct: 2400 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2459
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRM---EKDLNELQALI--EAHFENRKKEEEE 119
K + L+ K + + V + + ++ + L+E +L+ E E K + E+
Sbjct: 2460 EKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2518
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLA------------EERARREEEENRRK 167
L +D + + + R EQQR + + E+ERQ +A EE RR++EE ++
Sbjct: 2519 L--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2576
Query: 168 AEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ ++++ L+ ++ +R + Q E+ + LA +V A
Sbjct: 2577 EQQRRQQEELLA---------EENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Score = 40.8 bits (94), Expect = 0.001
Identities = 52/221 (23%), Positives = 96/221 (43%), Gaps = 28/221 (12%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+I E + E QE+ + + E + ++ +AE E E E+E + E
Sbjct: 2412 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE------ 2465
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR---MEKDLNELQALI--EAHFENRKKEE 117
L+ K + + V + + ++ + L+E +L+ E E K +
Sbjct: 2466 ---------AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 118 EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE-ERARREEEENRRKAEDEARKKK 176
E+L +D + + + R EQQR + + E+ERQ +A E ARR + E AE+ R+K+
Sbjct: 2517 EQL--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQ 2570
Query: 177 ALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ Q+ E + + Q RE+ + + + R LA
Sbjct: 2571 EELQQLE-QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2610
Score = 28.5 bits (62), Expect = 7.0
Identities = 37/174 (21%), Positives = 63/174 (36%), Gaps = 23/174 (13%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
IE+ + E+ Q+E A +Q EE + + E E + A +E EAE+G
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
+ + + + +R +++ + ++ +LQ L E H EE
Sbjct: 2569 KQEELQQL-----------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617
Query: 122 SL----------KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENR 165
S +D ++ AE + R K RL E EE R
Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 70.1 bits (170), Expect = 2e-12
Identities = 69/276 (25%), Positives = 130/276 (47%), Gaps = 28/276 (10%)
Query: 1 MSDIEEVVEEYEEEEQE-----EAAVEEQEEAAEEDAEAEAETE-ETRAEEDEEEEEAKE 54
M + E + E+ EE+E EAA+E+Q + AE A+A+A+ E E + + +EE
Sbjct: 1312 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371
Query: 55 AEDGPMEESKPKPRSFMPNLVPPKIPD-------GERVDFDDIHRKRMEKDLNELQALIE 107
E+ ++ + K RS L + + + + R R+E+++ ++ +E
Sbjct: 1372 REEAAVDAQQQK-RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1430
Query: 108 AHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEE---- 163
A R E EL +L R RAE AE Q+ + + E ER R ++ ++R+ +
Sbjct: 1431 ATERQRGGAEGELQAL-----RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1485
Query: 164 -NRRKAEDEA--RKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDH 220
+R KAE EA K++AL + ++ ER+ + + ER ++ ++ E + A
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1545
Query: 221 LNEDQ--LREKAKELWQSIYNLEAEKFDLQEKFKQQ 254
L + EK +L +S+ L+E+ +++
Sbjct: 1546 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1581
Score = 62.0 bits (149), Expect = 6e-10
Identities = 74/301 (24%), Positives = 130/301 (43%), Gaps = 47/301 (15%)
Query: 14 EEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPN 73
EE + +E+AA + AEAE E A E EAE E+ R +
Sbjct: 1779 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRR 1836
Query: 74 LVPPKIPDGERVDFD------DIH------RKRMEKDLNELQALIEAHFENRKKEEEELV 121
L + R++ DI RK + +L + L+E R++ EEE++
Sbjct: 1837 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1896
Query: 122 SLKDRIERRRAERAEQQ----RIRN------------EREKERQNRLA--EERARREEEE 163
+LK E+ A +AE + RIR+ E E RQ +LA EER RRE EE
Sbjct: 1897 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1956
Query: 164 NRRKA----EDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAID 219
+K+ E+ AR++KA +++ ER K + R +++ AE+ +
Sbjct: 1957 RVQKSLAAEEEAARQRKAA---------LEEVERLKAKVEEARRLRER--AEQESARQLQ 2005
Query: 220 HLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAK 279
E + E + ++ ++ +LQ+ +Q++ ++ LR ++ ++ +A+
Sbjct: 2006 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2065
Query: 280 V 280
V
Sbjct: 2066 V 2066
Score = 55.8 bits (133), Expect = 4e-08
Identities = 71/273 (26%), Positives = 118/273 (43%), Gaps = 46/273 (16%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETR-AEEDEEEEEAKEAEDGPMEESK 64
E E ++ +E+A Q +AA E EAE E R A+ ++ K+A D ME
Sbjct: 2080 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--- 2136
Query: 65 PKPRSFMPNLVPPKIPDGE-------RVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE 117
K + F + K + +++ D + ++++L L+A R + E
Sbjct: 2137 -KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2195
Query: 118 EELVS----------LKDRIERRR-----AERAEQQRIRNEREKERQNRLAEERAR---- 158
EEL S LK RIE ++ QR E E E+ ++AEE AR
Sbjct: 2196 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVA 2254
Query: 159 -REEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+E R+ AE++ +++AL+ M E+ ++ R K + L +++K LA
Sbjct: 2255 AQEAARLRQLAEEDLAQQRALAEKM-------LKEKMQAVQEATRLKAEAELLQQQKELA 2307
Query: 218 ID---HLNED--QLREKAKELWQSIY-NLEAEK 244
+ L ED Q+ ++ E Q LEAE+
Sbjct: 2308 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2340
Score = 51.6 bits (122), Expect = 8e-07
Identities = 61/259 (23%), Positives = 108/259 (41%), Gaps = 32/259 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE E EE+ + ++ +EEAA + A E E +A+ +E + AE + +
Sbjct: 1946 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2005
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ L + H +++ ELQ ++ +E+ L L+
Sbjct: 2006 LAQEAAQKRLQAE----------EKAHAFAVQQKEQELQQTLQ-------QEQSVLDQLR 2048
Query: 125 DRIE--RRRAERAEQQRIRNEREKERQNRLAEERARRE---EEENRRKAEDEARKKKALS 179
E RR AE AE+ R++ ERE + R EE R + EE+ + +A+ +A +K
Sbjct: 2049 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2108
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK-ELWQSIY 238
Q+ R++ Q +K+ AE K E LR+KA+ E +
Sbjct: 2109 EAE------QEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTL 2159
Query: 239 NLEAEKFDLQEKFKQQKYE 257
L+ E+ D Q+ ++ +
Sbjct: 2160 RLQLEETDHQKNLLDEELQ 2178
Score = 50.1 bits (118), Expect = 2e-06
Identities = 58/238 (24%), Positives = 102/238 (42%), Gaps = 51/238 (21%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
++E AV + E AE A+ +AE E R E + E E +
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ--------------------- 1603
Query: 75 VPPKIPDGERVDFDDIHRKRME-KDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAE 133
+ ++ R R++ +++ + ++L +A E +K+E E E RR
Sbjct: 1604 ----------LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER--------EARRRG 1645
Query: 134 RAEQQRIRN----EREKERQNRLAE----ERARREEEENRRKAEDEARKKKALSNMMHFG 185
+AE+Q +R E+E E+Q +LAE +R E+E R +AE E +++
Sbjct: 1646 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1705
Query: 186 GYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAE 243
++ + KRQ + K+ AE +LA E++ R ++ +S LEAE
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE---KSKQRLEAE 1760
Score = 49.3 bits (116), Expect = 4e-06
Identities = 56/230 (24%), Positives = 96/230 (41%), Gaps = 10/230 (4%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE V + E+ E ++Q EA EAE E E + + +E +AE+ ++S
Sbjct: 1566 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1625
Query: 65 PKPRSFMPNLVPPKIP--DGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ + + G+ + R+ E++L + + L E + R E+EL+
Sbjct: 1626 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1685
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
L R E+ EQQR E E R R A ++ +E A+ A + L++
Sbjct: 1686 L-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1740
Query: 183 HFGGYIQKTERKSGKRQTEREKKKKILAE---RRKVLAIDHLNEDQLREK 229
+ T KS +R + + LAE R + LA + + QL E+
Sbjct: 1741 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790
Score = 46.6 bits (109), Expect = 2e-05
Identities = 67/276 (24%), Positives = 114/276 (41%), Gaps = 59/276 (21%)
Query: 10 EYEEEEQEEAAVEE-----QEEAA---EEDAEAEAETEETRAEED---EEEEEAKEAEDG 58
E E+ EQ+ +EE Q EAA ++ E EAE + RAE + + A+E
Sbjct: 1689 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEE 118
E+SK +R++ + + + ++ L+AL E R+ EE
Sbjct: 1749 TSEKSK------------------QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1790
Query: 119 ELVSLKDRIERRRAER----AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARK 174
+ + ER AE+ E R++ E E +A + E E RR AEDEA +
Sbjct: 1791 DAARQRAEAERVLAEKLAAIGEATRLKTEAE------IALKEKEAENERLRRLAEDEAFQ 1844
Query: 175 KKALSNM--MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 232
++ L H ++ + +E E++K ++ ED LR++ ++
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-------------EDTLRQR-RQ 1890
Query: 233 LWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDN 268
+ + I L+A EK K E+ + RI N
Sbjct: 1891 VEEEILALKAS----FEKAAAGKAELELELGRIRSN 1922
Score = 43.1 bits (100), Expect = 3e-04
Identities = 47/230 (20%), Positives = 101/230 (43%), Gaps = 29/230 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + + ++ +E + E A ++ +T E + ++ + + E +E K
Sbjct: 2368 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2427
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRM---EKDLNELQALI--EAHFENRKKEEEE 119
K + L+ K + + V + + ++ + L+E +L+ E E K + E+
Sbjct: 2428 EKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2486
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLA------------EERARREEEENRRK 167
L +D + + + R EQQR + + E+ERQ +A EE RR++EE ++
Sbjct: 2487 L--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2544
Query: 168 AEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ ++++ L+ ++ +R + Q E+ + LA +V A
Sbjct: 2545 EQQRRQQEELLA---------EENQRLREQLQLLEEQHRAALAHSEEVTA 2585
Score = 40.8 bits (94), Expect = 0.001
Identities = 52/221 (23%), Positives = 96/221 (43%), Gaps = 28/221 (12%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+I E + E QE+ + + E + ++ +AE E E E+E + E
Sbjct: 2380 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE------ 2433
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR---MEKDLNELQALI--EAHFENRKKEE 117
L+ K + + V + + ++ + L+E +L+ E E K +
Sbjct: 2434 ---------AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2484
Query: 118 EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE-ERARREEEENRRKAEDEARKKK 176
E+L +D + + + R EQQR + + E+ERQ +A E ARR + E AE+ R+K+
Sbjct: 2485 EQL--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQ 2538
Query: 177 ALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ Q+ E + + Q RE+ + + + R LA
Sbjct: 2539 EELQQLE-QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2578
Score = 28.5 bits (62), Expect = 7.0
Identities = 37/174 (21%), Positives = 63/174 (36%), Gaps = 23/174 (13%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
IE+ + E+ Q+E A +Q EE + + E E + A +E EAE+G
Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2536
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
+ + + + +R +++ + ++ +LQ L E H EE
Sbjct: 2537 KQEELQQL-----------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2585
Query: 122 SL----------KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENR 165
S +D ++ AE + R K RL E EE R
Sbjct: 2586 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2639
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 70.1 bits (170), Expect = 2e-12
Identities = 69/276 (25%), Positives = 130/276 (47%), Gaps = 28/276 (10%)
Query: 1 MSDIEEVVEEYEEEEQE-----EAAVEEQEEAAEEDAEAEAETE-ETRAEEDEEEEEAKE 54
M + E + E+ EE+E EAA+E+Q + AE A+A+A+ E E + + +EE
Sbjct: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540
Query: 55 AEDGPMEESKPKPRSFMPNLVPPKIPD-------GERVDFDDIHRKRMEKDLNELQALIE 107
E+ ++ + K RS L + + + + R R+E+++ ++ +E
Sbjct: 1541 REEAAVDAQQQK-RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1599
Query: 108 AHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEE---- 163
A R E EL +L R RAE AE Q+ + + E ER R ++ ++R+ +
Sbjct: 1600 ATERQRGGAEGELQAL-----RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1654
Query: 164 -NRRKAEDEA--RKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDH 220
+R KAE EA K++AL + ++ ER+ + + ER ++ ++ E + A
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1714
Query: 221 LNEDQ--LREKAKELWQSIYNLEAEKFDLQEKFKQQ 254
L + EK +L +S+ L+E+ +++
Sbjct: 1715 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1750
Score = 62.0 bits (149), Expect = 6e-10
Identities = 74/301 (24%), Positives = 130/301 (43%), Gaps = 47/301 (15%)
Query: 14 EEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPN 73
EE + +E+AA + AEAE E A E EAE E+ R +
Sbjct: 1948 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRR 2005
Query: 74 LVPPKIPDGERVDFD------DIH------RKRMEKDLNELQALIEAHFENRKKEEEELV 121
L + R++ DI RK + +L + L+E R++ EEE++
Sbjct: 2006 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 2065
Query: 122 SLKDRIERRRAERAEQQ----RIRN------------EREKERQNRLA--EERARREEEE 163
+LK E+ A +AE + RIR+ E E RQ +LA EER RRE EE
Sbjct: 2066 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125
Query: 164 NRRKA----EDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAID 219
+K+ E+ AR++KA +++ ER K + R +++ AE+ +
Sbjct: 2126 RVQKSLAAEEEAARQRKAA---------LEEVERLKAKVEEARRLRER--AEQESARQLQ 2174
Query: 220 HLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAK 279
E + E + ++ ++ +LQ+ +Q++ ++ LR ++ ++ +A+
Sbjct: 2175 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2234
Query: 280 V 280
V
Sbjct: 2235 V 2235
Score = 55.8 bits (133), Expect = 4e-08
Identities = 71/273 (26%), Positives = 118/273 (43%), Gaps = 46/273 (16%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETR-AEEDEEEEEAKEAEDGPMEESK 64
E E ++ +E+A Q +AA E EAE E R A+ ++ K+A D ME
Sbjct: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--- 2305
Query: 65 PKPRSFMPNLVPPKIPDGE-------RVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE 117
K + F + K + +++ D + ++++L L+A R + E
Sbjct: 2306 -KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2364
Query: 118 EELVS----------LKDRIERRR-----AERAEQQRIRNEREKERQNRLAEERAR---- 158
EEL S LK RIE ++ QR E E E+ ++AEE AR
Sbjct: 2365 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVA 2423
Query: 159 -REEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+E R+ AE++ +++AL+ M E+ ++ R K + L +++K LA
Sbjct: 2424 AQEAARLRQLAEEDLAQQRALAEKM-------LKEKMQAVQEATRLKAEAELLQQQKELA 2476
Query: 218 ID---HLNED--QLREKAKELWQSIY-NLEAEK 244
+ L ED Q+ ++ E Q LEAE+
Sbjct: 2477 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2509
Score = 51.6 bits (122), Expect = 8e-07
Identities = 61/259 (23%), Positives = 108/259 (41%), Gaps = 32/259 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE E EE+ + ++ +EEAA + A E E +A+ +E + AE + +
Sbjct: 2115 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2174
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ L + H +++ ELQ ++ +E+ L L+
Sbjct: 2175 LAQEAAQKRLQAE----------EKAHAFAVQQKEQELQQTLQ-------QEQSVLDQLR 2217
Query: 125 DRIE--RRRAERAEQQRIRNEREKERQNRLAEERARRE---EEENRRKAEDEARKKKALS 179
E RR AE AE+ R++ ERE + R EE R + EE+ + +A+ +A +K
Sbjct: 2218 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2277
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK-ELWQSIY 238
Q+ R++ Q +K+ AE K E LR+KA+ E +
Sbjct: 2278 EAE------QEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTL 2328
Query: 239 NLEAEKFDLQEKFKQQKYE 257
L+ E+ D Q+ ++ +
Sbjct: 2329 RLQLEETDHQKNLLDEELQ 2347
Score = 50.1 bits (118), Expect = 2e-06
Identities = 58/238 (24%), Positives = 102/238 (42%), Gaps = 51/238 (21%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
++E AV + E AE A+ +AE E R E + E E +
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ--------------------- 1772
Query: 75 VPPKIPDGERVDFDDIHRKRME-KDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAE 133
+ ++ R R++ +++ + ++L +A E +K+E E E RR
Sbjct: 1773 ----------LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER--------EARRRG 1814
Query: 134 RAEQQRIRN----EREKERQNRLAE----ERARREEEENRRKAEDEARKKKALSNMMHFG 185
+AE+Q +R E+E E+Q +LAE +R E+E R +AE E +++
Sbjct: 1815 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1874
Query: 186 GYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAE 243
++ + KRQ + K+ AE +LA E++ R ++ +S LEAE
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE---KSKQRLEAE 1929
Score = 49.3 bits (116), Expect = 4e-06
Identities = 56/230 (24%), Positives = 96/230 (41%), Gaps = 10/230 (4%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE V + E+ E ++Q EA EAE E E + + +E +AE+ ++S
Sbjct: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1794
Query: 65 PKPRSFMPNLVPPKIP--DGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ + + G+ + R+ E++L + + L E + R E+EL+
Sbjct: 1795 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1854
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
L R E+ EQQR E E R R A ++ +E A+ A + L++
Sbjct: 1855 L-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1909
Query: 183 HFGGYIQKTERKSGKRQTEREKKKKILAE---RRKVLAIDHLNEDQLREK 229
+ T KS +R + + LAE R + LA + + QL E+
Sbjct: 1910 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1959
Score = 46.6 bits (109), Expect = 2e-05
Identities = 67/276 (24%), Positives = 114/276 (41%), Gaps = 59/276 (21%)
Query: 10 EYEEEEQEEAAVEE-----QEEAA---EEDAEAEAETEETRAEED---EEEEEAKEAEDG 58
E E+ EQ+ +EE Q EAA ++ E EAE + RAE + + A+E
Sbjct: 1858 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEE 118
E+SK +R++ + + + ++ L+AL E R+ EE
Sbjct: 1918 TSEKSK------------------QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1959
Query: 119 ELVSLKDRIERRRAER----AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARK 174
+ + ER AE+ E R++ E E +A + E E RR AEDEA +
Sbjct: 1960 DAARQRAEAERVLAEKLAAIGEATRLKTEAE------IALKEKEAENERLRRLAEDEAFQ 2013
Query: 175 KKALSNM--MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 232
++ L H ++ + +E E++K ++ ED LR++ ++
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-------------EDTLRQR-RQ 2059
Query: 233 LWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDN 268
+ + I L+A EK K E+ + RI N
Sbjct: 2060 VEEEILALKAS----FEKAAAGKAELELELGRIRSN 2091
Score = 43.1 bits (100), Expect = 3e-04
Identities = 47/230 (20%), Positives = 101/230 (43%), Gaps = 29/230 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + + ++ +E + E A ++ +T E + ++ + + E +E K
Sbjct: 2537 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2596
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRM---EKDLNELQALI--EAHFENRKKEEEE 119
K + L+ K + + V + + ++ + L+E +L+ E E K + E+
Sbjct: 2597 EKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2655
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLA------------EERARREEEENRRK 167
L +D + + + R EQQR + + E+ERQ +A EE RR++EE ++
Sbjct: 2656 L--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2713
Query: 168 AEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ ++++ L+ ++ +R + Q E+ + LA +V A
Sbjct: 2714 EQQRRQQEELLA---------EENQRLREQLQLLEEQHRAALAHSEEVTA 2754
Score = 40.8 bits (94), Expect = 0.001
Identities = 52/221 (23%), Positives = 96/221 (43%), Gaps = 28/221 (12%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+I E + E QE+ + + E + ++ +AE E E E+E + E
Sbjct: 2549 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE------ 2602
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR---MEKDLNELQALI--EAHFENRKKEE 117
L+ K + + V + + ++ + L+E +L+ E E K +
Sbjct: 2603 ---------AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2653
Query: 118 EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE-ERARREEEENRRKAEDEARKKK 176
E+L +D + + + R EQQR + + E+ERQ +A E ARR + E AE+ R+K+
Sbjct: 2654 EQL--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQ 2707
Query: 177 ALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ Q+ E + + Q RE+ + + + R LA
Sbjct: 2708 EELQQLE-QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2747
Score = 28.5 bits (62), Expect = 7.0
Identities = 37/174 (21%), Positives = 63/174 (36%), Gaps = 23/174 (13%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
IE+ + E+ Q+E A +Q EE + + E E + A +E EAE+G
Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2705
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
+ + + + +R +++ + ++ +LQ L E H EE
Sbjct: 2706 KQEELQQL-----------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754
Query: 122 SL----------KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENR 165
S +D ++ AE + R K RL E EE R
Sbjct: 2755 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2808
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 70.1 bits (170), Expect = 2e-12
Identities = 69/276 (25%), Positives = 130/276 (47%), Gaps = 28/276 (10%)
Query: 1 MSDIEEVVEEYEEEEQE-----EAAVEEQEEAAEEDAEAEAETE-ETRAEEDEEEEEAKE 54
M + E + E+ EE+E EAA+E+Q + AE A+A+A+ E E + + +EE
Sbjct: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
Query: 55 AEDGPMEESKPKPRSFMPNLVPPKIPD-------GERVDFDDIHRKRMEKDLNELQALIE 107
E+ ++ + K RS L + + + + R R+E+++ ++ +E
Sbjct: 1382 REEAAVDAQQQK-RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440
Query: 108 AHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEE---- 163
A R E EL +L R RAE AE Q+ + + E ER R ++ ++R+ +
Sbjct: 1441 ATERQRGGAEGELQAL-----RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495
Query: 164 -NRRKAEDEA--RKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDH 220
+R KAE EA K++AL + ++ ER+ + + ER ++ ++ E + A
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1555
Query: 221 LNEDQ--LREKAKELWQSIYNLEAEKFDLQEKFKQQ 254
L + EK +L +S+ L+E+ +++
Sbjct: 1556 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1591
Score = 62.0 bits (149), Expect = 6e-10
Identities = 74/301 (24%), Positives = 130/301 (43%), Gaps = 47/301 (15%)
Query: 14 EEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPN 73
EE + +E+AA + AEAE E A E EAE E+ R +
Sbjct: 1789 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRR 1846
Query: 74 LVPPKIPDGERVDFD------DIH------RKRMEKDLNELQALIEAHFENRKKEEEELV 121
L + R++ DI RK + +L + L+E R++ EEE++
Sbjct: 1847 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1906
Query: 122 SLKDRIERRRAERAEQQ----RIRN------------EREKERQNRLA--EERARREEEE 163
+LK E+ A +AE + RIR+ E E RQ +LA EER RRE EE
Sbjct: 1907 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1966
Query: 164 NRRKA----EDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAID 219
+K+ E+ AR++KA +++ ER K + R +++ AE+ +
Sbjct: 1967 RVQKSLAAEEEAARQRKAA---------LEEVERLKAKVEEARRLRER--AEQESARQLQ 2015
Query: 220 HLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAK 279
E + E + ++ ++ +LQ+ +Q++ ++ LR ++ ++ +A+
Sbjct: 2016 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2075
Query: 280 V 280
V
Sbjct: 2076 V 2076
Score = 55.8 bits (133), Expect = 4e-08
Identities = 71/273 (26%), Positives = 118/273 (43%), Gaps = 46/273 (16%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETR-AEEDEEEEEAKEAEDGPMEESK 64
E E ++ +E+A Q +AA E EAE E R A+ ++ K+A D ME
Sbjct: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--- 2146
Query: 65 PKPRSFMPNLVPPKIPDGE-------RVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE 117
K + F + K + +++ D + ++++L L+A R + E
Sbjct: 2147 -KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2205
Query: 118 EELVS----------LKDRIERRR-----AERAEQQRIRNEREKERQNRLAEERAR---- 158
EEL S LK RIE ++ QR E E E+ ++AEE AR
Sbjct: 2206 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVA 2264
Query: 159 -REEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+E R+ AE++ +++AL+ M E+ ++ R K + L +++K LA
Sbjct: 2265 AQEAARLRQLAEEDLAQQRALAEKM-------LKEKMQAVQEATRLKAEAELLQQQKELA 2317
Query: 218 ID---HLNED--QLREKAKELWQSIY-NLEAEK 244
+ L ED Q+ ++ E Q LEAE+
Sbjct: 2318 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2350
Score = 51.6 bits (122), Expect = 8e-07
Identities = 61/259 (23%), Positives = 108/259 (41%), Gaps = 32/259 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE E EE+ + ++ +EEAA + A E E +A+ +E + AE + +
Sbjct: 1956 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2015
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ L + H +++ ELQ ++ +E+ L L+
Sbjct: 2016 LAQEAAQKRLQAE----------EKAHAFAVQQKEQELQQTLQ-------QEQSVLDQLR 2058
Query: 125 DRIE--RRRAERAEQQRIRNEREKERQNRLAEERARRE---EEENRRKAEDEARKKKALS 179
E RR AE AE+ R++ ERE + R EE R + EE+ + +A+ +A +K
Sbjct: 2059 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2118
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK-ELWQSIY 238
Q+ R++ Q +K+ AE K E LR+KA+ E +
Sbjct: 2119 EAE------QEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTL 2169
Query: 239 NLEAEKFDLQEKFKQQKYE 257
L+ E+ D Q+ ++ +
Sbjct: 2170 RLQLEETDHQKNLLDEELQ 2188
Score = 50.1 bits (118), Expect = 2e-06
Identities = 58/238 (24%), Positives = 102/238 (42%), Gaps = 51/238 (21%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
++E AV + E AE A+ +AE E R E + E E +
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ--------------------- 1613
Query: 75 VPPKIPDGERVDFDDIHRKRME-KDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAE 133
+ ++ R R++ +++ + ++L +A E +K+E E E RR
Sbjct: 1614 ----------LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER--------EARRRG 1655
Query: 134 RAEQQRIRN----EREKERQNRLAE----ERARREEEENRRKAEDEARKKKALSNMMHFG 185
+AE+Q +R E+E E+Q +LAE +R E+E R +AE E +++
Sbjct: 1656 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1715
Query: 186 GYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAE 243
++ + KRQ + K+ AE +LA E++ R ++ +S LEAE
Sbjct: 1716 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE---KSKQRLEAE 1770
Score = 49.3 bits (116), Expect = 4e-06
Identities = 56/230 (24%), Positives = 96/230 (41%), Gaps = 10/230 (4%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE V + E+ E ++Q EA EAE E E + + +E +AE+ ++S
Sbjct: 1576 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1635
Query: 65 PKPRSFMPNLVPPKIP--DGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ + + G+ + R+ E++L + + L E + R E+EL+
Sbjct: 1636 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1695
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
L R E+ EQQR E E R R A ++ +E A+ A + L++
Sbjct: 1696 L-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1750
Query: 183 HFGGYIQKTERKSGKRQTEREKKKKILAE---RRKVLAIDHLNEDQLREK 229
+ T KS +R + + LAE R + LA + + QL E+
Sbjct: 1751 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800
Score = 46.6 bits (109), Expect = 2e-05
Identities = 67/276 (24%), Positives = 114/276 (41%), Gaps = 59/276 (21%)
Query: 10 EYEEEEQEEAAVEE-----QEEAA---EEDAEAEAETEETRAEED---EEEEEAKEAEDG 58
E E+ EQ+ +EE Q EAA ++ E EAE + RAE + + A+E
Sbjct: 1699 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEE 118
E+SK +R++ + + + ++ L+AL E R+ EE
Sbjct: 1759 TSEKSK------------------QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800
Query: 119 ELVSLKDRIERRRAER----AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARK 174
+ + ER AE+ E R++ E E +A + E E RR AEDEA +
Sbjct: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAE------IALKEKEAENERLRRLAEDEAFQ 1854
Query: 175 KKALSNM--MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 232
++ L H ++ + +E E++K ++ ED LR++ ++
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-------------EDTLRQR-RQ 1900
Query: 233 LWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDN 268
+ + I L+A EK K E+ + RI N
Sbjct: 1901 VEEEILALKAS----FEKAAAGKAELELELGRIRSN 1932
Score = 43.1 bits (100), Expect = 3e-04
Identities = 47/230 (20%), Positives = 101/230 (43%), Gaps = 29/230 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + + ++ +E + E A ++ +T E + ++ + + E +E K
Sbjct: 2378 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2437
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRM---EKDLNELQALI--EAHFENRKKEEEE 119
K + L+ K + + V + + ++ + L+E +L+ E E K + E+
Sbjct: 2438 EKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2496
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLA------------EERARREEEENRRK 167
L +D + + + R EQQR + + E+ERQ +A EE RR++EE ++
Sbjct: 2497 L--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2554
Query: 168 AEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ ++++ L+ ++ +R + Q E+ + LA +V A
Sbjct: 2555 EQQRRQQEELLA---------EENQRLREQLQLLEEQHRAALAHSEEVTA 2595
Score = 40.8 bits (94), Expect = 0.001
Identities = 52/221 (23%), Positives = 96/221 (43%), Gaps = 28/221 (12%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+I E + E QE+ + + E + ++ +AE E E E+E + E
Sbjct: 2390 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE------ 2443
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR---MEKDLNELQALI--EAHFENRKKEE 117
L+ K + + V + + ++ + L+E +L+ E E K +
Sbjct: 2444 ---------AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2494
Query: 118 EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE-ERARREEEENRRKAEDEARKKK 176
E+L +D + + + R EQQR + + E+ERQ +A E ARR + E AE+ R+K+
Sbjct: 2495 EQL--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQ 2548
Query: 177 ALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ Q+ E + + Q RE+ + + + R LA
Sbjct: 2549 EELQQLE-QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2588
Score = 28.5 bits (62), Expect = 7.0
Identities = 37/174 (21%), Positives = 63/174 (36%), Gaps = 23/174 (13%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
IE+ + E+ Q+E A +Q EE + + E E + A +E EAE+G
Sbjct: 2487 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2546
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
+ + + + +R +++ + ++ +LQ L E H EE
Sbjct: 2547 KQEELQQL-----------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2595
Query: 122 SL----------KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENR 165
S +D ++ AE + R K RL E EE R
Sbjct: 2596 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2649
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 70.1 bits (170), Expect = 2e-12
Identities = 69/276 (25%), Positives = 130/276 (47%), Gaps = 28/276 (10%)
Query: 1 MSDIEEVVEEYEEEEQE-----EAAVEEQEEAAEEDAEAEAETE-ETRAEEDEEEEEAKE 54
M + E + E+ EE+E EAA+E+Q + AE A+A+A+ E E + + +EE
Sbjct: 1330 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389
Query: 55 AEDGPMEESKPKPRSFMPNLVPPKIPD-------GERVDFDDIHRKRMEKDLNELQALIE 107
E+ ++ + K RS L + + + + R R+E+++ ++ +E
Sbjct: 1390 REEAAVDAQQQK-RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1448
Query: 108 AHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEE---- 163
A R E EL +L R RAE AE Q+ + + E ER R ++ ++R+ +
Sbjct: 1449 ATERQRGGAEGELQAL-----RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1503
Query: 164 -NRRKAEDEA--RKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDH 220
+R KAE EA K++AL + ++ ER+ + + ER ++ ++ E + A
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1563
Query: 221 LNEDQ--LREKAKELWQSIYNLEAEKFDLQEKFKQQ 254
L + EK +L +S+ L+E+ +++
Sbjct: 1564 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1599
Score = 62.0 bits (149), Expect = 6e-10
Identities = 74/301 (24%), Positives = 130/301 (43%), Gaps = 47/301 (15%)
Query: 14 EEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPN 73
EE + +E+AA + AEAE E A E EAE E+ R +
Sbjct: 1797 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRR 1854
Query: 74 LVPPKIPDGERVDFD------DIH------RKRMEKDLNELQALIEAHFENRKKEEEELV 121
L + R++ DI RK + +L + L+E R++ EEE++
Sbjct: 1855 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1914
Query: 122 SLKDRIERRRAERAEQQ----RIRN------------EREKERQNRLA--EERARREEEE 163
+LK E+ A +AE + RIR+ E E RQ +LA EER RRE EE
Sbjct: 1915 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1974
Query: 164 NRRKA----EDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAID 219
+K+ E+ AR++KA +++ ER K + R +++ AE+ +
Sbjct: 1975 RVQKSLAAEEEAARQRKAA---------LEEVERLKAKVEEARRLRER--AEQESARQLQ 2023
Query: 220 HLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAK 279
E + E + ++ ++ +LQ+ +Q++ ++ LR ++ ++ +A+
Sbjct: 2024 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2083
Query: 280 V 280
V
Sbjct: 2084 V 2084
Score = 55.8 bits (133), Expect = 4e-08
Identities = 71/273 (26%), Positives = 118/273 (43%), Gaps = 46/273 (16%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETR-AEEDEEEEEAKEAEDGPMEESK 64
E E ++ +E+A Q +AA E EAE E R A+ ++ K+A D ME
Sbjct: 2098 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--- 2154
Query: 65 PKPRSFMPNLVPPKIPDGE-------RVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE 117
K + F + K + +++ D + ++++L L+A R + E
Sbjct: 2155 -KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2213
Query: 118 EELVS----------LKDRIERRR-----AERAEQQRIRNEREKERQNRLAEERAR---- 158
EEL S LK RIE ++ QR E E E+ ++AEE AR
Sbjct: 2214 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVA 2272
Query: 159 -REEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+E R+ AE++ +++AL+ M E+ ++ R K + L +++K LA
Sbjct: 2273 AQEAARLRQLAEEDLAQQRALAEKM-------LKEKMQAVQEATRLKAEAELLQQQKELA 2325
Query: 218 ID---HLNED--QLREKAKELWQSIY-NLEAEK 244
+ L ED Q+ ++ E Q LEAE+
Sbjct: 2326 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2358
Score = 51.6 bits (122), Expect = 8e-07
Identities = 61/259 (23%), Positives = 108/259 (41%), Gaps = 32/259 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE E EE+ + ++ +EEAA + A E E +A+ +E + AE + +
Sbjct: 1964 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2023
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ L + H +++ ELQ ++ +E+ L L+
Sbjct: 2024 LAQEAAQKRLQAE----------EKAHAFAVQQKEQELQQTLQ-------QEQSVLDQLR 2066
Query: 125 DRIE--RRRAERAEQQRIRNEREKERQNRLAEERARRE---EEENRRKAEDEARKKKALS 179
E RR AE AE+ R++ ERE + R EE R + EE+ + +A+ +A +K
Sbjct: 2067 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2126
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK-ELWQSIY 238
Q+ R++ Q +K+ AE K E LR+KA+ E +
Sbjct: 2127 EAE------QEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTL 2177
Query: 239 NLEAEKFDLQEKFKQQKYE 257
L+ E+ D Q+ ++ +
Sbjct: 2178 RLQLEETDHQKNLLDEELQ 2196
Score = 50.1 bits (118), Expect = 2e-06
Identities = 58/238 (24%), Positives = 102/238 (42%), Gaps = 51/238 (21%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
++E AV + E AE A+ +AE E R E + E E +
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ--------------------- 1621
Query: 75 VPPKIPDGERVDFDDIHRKRME-KDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAE 133
+ ++ R R++ +++ + ++L +A E +K+E E E RR
Sbjct: 1622 ----------LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER--------EARRRG 1663
Query: 134 RAEQQRIRN----EREKERQNRLAE----ERARREEEENRRKAEDEARKKKALSNMMHFG 185
+AE+Q +R E+E E+Q +LAE +R E+E R +AE E +++
Sbjct: 1664 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1723
Query: 186 GYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAE 243
++ + KRQ + K+ AE +LA E++ R ++ +S LEAE
Sbjct: 1724 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE---KSKQRLEAE 1778
Score = 49.3 bits (116), Expect = 4e-06
Identities = 56/230 (24%), Positives = 96/230 (41%), Gaps = 10/230 (4%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE V + E+ E ++Q EA EAE E E + + +E +AE+ ++S
Sbjct: 1584 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1643
Query: 65 PKPRSFMPNLVPPKIP--DGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ + + G+ + R+ E++L + + L E + R E+EL+
Sbjct: 1644 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1703
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
L R E+ EQQR E E R R A ++ +E A+ A + L++
Sbjct: 1704 L-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1758
Query: 183 HFGGYIQKTERKSGKRQTEREKKKKILAE---RRKVLAIDHLNEDQLREK 229
+ T KS +R + + LAE R + LA + + QL E+
Sbjct: 1759 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1808
Score = 46.6 bits (109), Expect = 2e-05
Identities = 67/276 (24%), Positives = 114/276 (41%), Gaps = 59/276 (21%)
Query: 10 EYEEEEQEEAAVEE-----QEEAA---EEDAEAEAETEETRAEED---EEEEEAKEAEDG 58
E E+ EQ+ +EE Q EAA ++ E EAE + RAE + + A+E
Sbjct: 1707 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEE 118
E+SK +R++ + + + ++ L+AL E R+ EE
Sbjct: 1767 TSEKSK------------------QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1808
Query: 119 ELVSLKDRIERRRAER----AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARK 174
+ + ER AE+ E R++ E E +A + E E RR AEDEA +
Sbjct: 1809 DAARQRAEAERVLAEKLAAIGEATRLKTEAE------IALKEKEAENERLRRLAEDEAFQ 1862
Query: 175 KKALSNM--MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 232
++ L H ++ + +E E++K ++ ED LR++ ++
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-------------EDTLRQR-RQ 1908
Query: 233 LWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDN 268
+ + I L+A EK K E+ + RI N
Sbjct: 1909 VEEEILALKAS----FEKAAAGKAELELELGRIRSN 1940
Score = 43.1 bits (100), Expect = 3e-04
Identities = 47/230 (20%), Positives = 101/230 (43%), Gaps = 29/230 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + + ++ +E + E A ++ +T E + ++ + + E +E K
Sbjct: 2386 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2445
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRM---EKDLNELQALI--EAHFENRKKEEEE 119
K + L+ K + + V + + ++ + L+E +L+ E E K + E+
Sbjct: 2446 EKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2504
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLA------------EERARREEEENRRK 167
L +D + + + R EQQR + + E+ERQ +A EE RR++EE ++
Sbjct: 2505 L--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2562
Query: 168 AEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ ++++ L+ ++ +R + Q E+ + LA +V A
Sbjct: 2563 EQQRRQQEELLA---------EENQRLREQLQLLEEQHRAALAHSEEVTA 2603
Score = 40.8 bits (94), Expect = 0.001
Identities = 52/221 (23%), Positives = 96/221 (43%), Gaps = 28/221 (12%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+I E + E QE+ + + E + ++ +AE E E E+E + E
Sbjct: 2398 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE------ 2451
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR---MEKDLNELQALI--EAHFENRKKEE 117
L+ K + + V + + ++ + L+E +L+ E E K +
Sbjct: 2452 ---------AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2502
Query: 118 EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE-ERARREEEENRRKAEDEARKKK 176
E+L +D + + + R EQQR + + E+ERQ +A E ARR + E AE+ R+K+
Sbjct: 2503 EQL--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQ 2556
Query: 177 ALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ Q+ E + + Q RE+ + + + R LA
Sbjct: 2557 EELQQLE-QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2596
Score = 28.5 bits (62), Expect = 7.0
Identities = 37/174 (21%), Positives = 63/174 (36%), Gaps = 23/174 (13%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
IE+ + E+ Q+E A +Q EE + + E E + A +E EAE+G
Sbjct: 2495 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2554
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
+ + + + +R +++ + ++ +LQ L E H EE
Sbjct: 2555 KQEELQQL-----------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2603
Query: 122 SL----------KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENR 165
S +D ++ AE + R K RL E EE R
Sbjct: 2604 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2657
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 70.1 bits (170), Expect = 2e-12
Identities = 69/276 (25%), Positives = 130/276 (47%), Gaps = 28/276 (10%)
Query: 1 MSDIEEVVEEYEEEEQE-----EAAVEEQEEAAEEDAEAEAETE-ETRAEEDEEEEEAKE 54
M + E + E+ EE+E EAA+E+Q + AE A+A+A+ E E + + +EE
Sbjct: 1371 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
Query: 55 AEDGPMEESKPKPRSFMPNLVPPKIPD-------GERVDFDDIHRKRMEKDLNELQALIE 107
E+ ++ + K RS L + + + + R R+E+++ ++ +E
Sbjct: 1431 REEAAVDAQQQK-RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489
Query: 108 AHFENRKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEE---- 163
A R E EL +L R RAE AE Q+ + + E ER R ++ ++R+ +
Sbjct: 1490 ATERQRGGAEGELQAL-----RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1544
Query: 164 -NRRKAEDEA--RKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDH 220
+R KAE EA K++AL + ++ ER+ + + ER ++ ++ E + A
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAE 1604
Query: 221 LNEDQ--LREKAKELWQSIYNLEAEKFDLQEKFKQQ 254
L + EK +L +S+ L+E+ +++
Sbjct: 1605 LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1640
Score = 62.0 bits (149), Expect = 6e-10
Identities = 74/301 (24%), Positives = 130/301 (43%), Gaps = 47/301 (15%)
Query: 14 EEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPN 73
EE + +E+AA + AEAE E A E EAE E+ R +
Sbjct: 1838 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER--LRR 1895
Query: 74 LVPPKIPDGERVDFD------DIH------RKRMEKDLNELQALIEAHFENRKKEEEELV 121
L + R++ DI RK + +L + L+E R++ EEE++
Sbjct: 1896 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1955
Query: 122 SLKDRIERRRAERAEQQ----RIRN------------EREKERQNRLA--EERARREEEE 163
+LK E+ A +AE + RIR+ E E RQ +LA EER RRE EE
Sbjct: 1956 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2015
Query: 164 NRRKA----EDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAID 219
+K+ E+ AR++KA +++ ER K + R +++ AE+ +
Sbjct: 2016 RVQKSLAAEEEAARQRKAA---------LEEVERLKAKVEEARRLRER--AEQESARQLQ 2064
Query: 220 HLNEDQLREKAKELWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDNQKVSKTRGKAK 279
E + E + ++ ++ +LQ+ +Q++ ++ LR ++ ++ +A+
Sbjct: 2065 LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEAR 2124
Query: 280 V 280
V
Sbjct: 2125 V 2125
Score = 55.8 bits (133), Expect = 4e-08
Identities = 71/273 (26%), Positives = 118/273 (43%), Gaps = 46/273 (16%)
Query: 6 EVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETR-AEEDEEEEEAKEAEDGPMEESK 64
E E ++ +E+A Q +AA E EAE E R A+ ++ K+A D ME
Sbjct: 2139 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--- 2195
Query: 65 PKPRSFMPNLVPPKIPDGE-------RVDFDDIHRKRMEKDLNELQALIEAHFENRKKEE 117
K + F + K + +++ D + ++++L L+A R + E
Sbjct: 2196 -KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2254
Query: 118 EELVS----------LKDRIERRR-----AERAEQQRIRNEREKERQNRLAEERAR---- 158
EEL S LK RIE ++ QR E E E+ ++AEE AR
Sbjct: 2255 EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVA 2313
Query: 159 -REEEENRRKAEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+E R+ AE++ +++AL+ M E+ ++ R K + L +++K LA
Sbjct: 2314 AQEAARLRQLAEEDLAQQRALAEKM-------LKEKMQAVQEATRLKAEAELLQQQKELA 2366
Query: 218 ID---HLNED--QLREKAKELWQSIY-NLEAEK 244
+ L ED Q+ ++ E Q LEAE+
Sbjct: 2367 QEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2399
Score = 51.6 bits (122), Expect = 8e-07
Identities = 61/259 (23%), Positives = 108/259 (41%), Gaps = 32/259 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE E EE+ + ++ +EEAA + A E E +A+ +E + AE + +
Sbjct: 2005 EEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ 2064
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVSLK 124
+ L + H +++ ELQ ++ +E+ L L+
Sbjct: 2065 LAQEAAQKRLQAE----------EKAHAFAVQQKEQELQQTLQ-------QEQSVLDQLR 2107
Query: 125 DRIE--RRRAERAEQQRIRNEREKERQNRLAEERARRE---EEENRRKAEDEARKKKALS 179
E RR AE AE+ R++ ERE + R EE R + EE+ + +A+ +A +K
Sbjct: 2108 GEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK 2167
Query: 180 NMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAK-ELWQSIY 238
Q+ R++ Q +K+ AE K E LR+KA+ E +
Sbjct: 2168 EAE------QEAARRAQAEQAALRQKQAADAEMEK---HKKFAEQTLRQKAQVEQELTTL 2218
Query: 239 NLEAEKFDLQEKFKQQKYE 257
L+ E+ D Q+ ++ +
Sbjct: 2219 RLQLEETDHQKNLLDEELQ 2237
Score = 50.1 bits (118), Expect = 2e-06
Identities = 58/238 (24%), Positives = 102/238 (42%), Gaps = 51/238 (21%)
Query: 15 EQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESKPKPRSFMPNL 74
++E AV + E AE A+ +AE E R E + E E +
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ--------------------- 1662
Query: 75 VPPKIPDGERVDFDDIHRKRME-KDLNELQALIEAHFENRKKEEEELVSLKDRIERRRAE 133
+ ++ R R++ +++ + ++L +A E +K+E E E RR
Sbjct: 1663 ----------LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER--------EARRRG 1704
Query: 134 RAEQQRIRN----EREKERQNRLAE----ERARREEEENRRKAEDEARKKKALSNMMHFG 185
+AE+Q +R E+E E+Q +LAE +R E+E R +AE E +++
Sbjct: 1705 KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1764
Query: 186 GYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKELWQSIYNLEAE 243
++ + KRQ + K+ AE +LA E++ R ++ +S LEAE
Sbjct: 1765 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE---KSKQRLEAE 1819
Score = 49.3 bits (116), Expect = 4e-06
Identities = 56/230 (24%), Positives = 96/230 (41%), Gaps = 10/230 (4%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE V + E+ E ++Q EA EAE E E + + +E +AE+ ++S
Sbjct: 1625 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1684
Query: 65 PKPRSFMPNLVPPKIP--DGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELVS 122
+ + + G+ + R+ E++L + + L E + R E+EL+
Sbjct: 1685 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1744
Query: 123 LKDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARKKKALSNMM 182
L R E+ EQQR E E R R A ++ +E A+ A + L++
Sbjct: 1745 L-----RAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1799
Query: 183 HFGGYIQKTERKSGKRQTEREKKKKILAE---RRKVLAIDHLNEDQLREK 229
+ T KS +R + + LAE R + LA + + QL E+
Sbjct: 1800 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1849
Score = 46.6 bits (109), Expect = 2e-05
Identities = 67/276 (24%), Positives = 114/276 (41%), Gaps = 59/276 (21%)
Query: 10 EYEEEEQEEAAVEE-----QEEAA---EEDAEAEAETEETRAEED---EEEEEAKEAEDG 58
E E+ EQ+ +EE Q EAA ++ E EAE + RAE + + A+E
Sbjct: 1748 ETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1807
Query: 59 PMEESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEE 118
E+SK +R++ + + + ++ L+AL E R+ EE
Sbjct: 1808 TSEKSK------------------QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1849
Query: 119 ELVSLKDRIERRRAER----AEQQRIRNEREKERQNRLAEERARREEEENRRKAEDEARK 174
+ + ER AE+ E R++ E E +A + E E RR AEDEA +
Sbjct: 1850 DAARQRAEAERVLAEKLAAIGEATRLKTEAE------IALKEKEAENERLRRLAEDEAFQ 1903
Query: 175 KKALSNM--MHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLAIDHLNEDQLREKAKE 232
++ L H ++ + +E E++K ++ ED LR++ ++
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV-------------EDTLRQR-RQ 1949
Query: 233 LWQSIYNLEAEKFDLQEKFKQQKYEINVLRNRINDN 268
+ + I L+A EK K E+ + RI N
Sbjct: 1950 VEEEILALKAS----FEKAAAGKAELELELGRIRSN 1981
Score = 43.1 bits (100), Expect = 3e-04
Identities = 47/230 (20%), Positives = 101/230 (43%), Gaps = 29/230 (12%)
Query: 5 EEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEESK 64
EE + + ++ +E + E A ++ +T E + ++ + + E +E K
Sbjct: 2427 EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREK 2486
Query: 65 PKPRSFMPNLVPPKIPDGERVDFDDIHRKRM---EKDLNELQALI--EAHFENRKKEEEE 119
K + L+ K + + V + + ++ + L+E +L+ E E K + E+
Sbjct: 2487 EKLQQ-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQ 2545
Query: 120 LVSLKDRIERRRAERAEQQRIRNEREKERQNRLA------------EERARREEEENRRK 167
L +D + + + R EQQR + + E+ERQ +A EE RR++EE ++
Sbjct: 2546 L--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQL 2603
Query: 168 AEDEARKKKALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ ++++ L+ ++ +R + Q E+ + LA +V A
Sbjct: 2604 EQQRRQQEELLA---------EENQRLREQLQLLEEQHRAALAHSEEVTA 2644
Score = 40.8 bits (94), Expect = 0.001
Identities = 52/221 (23%), Positives = 96/221 (43%), Gaps = 28/221 (12%)
Query: 3 DIEEVVEEYEEEEQEEAAVEEQEEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPMEE 62
+I E + E QE+ + + E + ++ +AE E E E+E + E
Sbjct: 2439 EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE------ 2492
Query: 63 SKPKPRSFMPNLVPPKIPDGERVDFDDIHRKR---MEKDLNELQALI--EAHFENRKKEE 117
L+ K + + V + + ++ + L+E +L+ E E K +
Sbjct: 2493 ---------AKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2543
Query: 118 EELVSLKDRIERRRAERAEQQRIRNEREKERQNRLAE-ERARREEEENRRKAEDEARKKK 176
E+L +D + + + R EQQR + + E+ERQ +A E ARR + E AE+ R+K+
Sbjct: 2544 EQL--FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE----AEEGVRRKQ 2597
Query: 177 ALSNMMHFGGYIQKTERKSGKRQTEREKKKKILAERRKVLA 217
+ Q+ E + + Q RE+ + + + R LA
Sbjct: 2598 EELQQLE-QQRRQQEELLAEENQRLREQLQLLEEQHRAALA 2637
Score = 28.5 bits (62), Expect = 7.0
Identities = 37/174 (21%), Positives = 63/174 (36%), Gaps = 23/174 (13%)
Query: 4 IEEVVEEYEEEEQEEAAVEEQ--EEAAEEDAEAEAETEETRAEEDEEEEEAKEAEDGPME 61
IE+ + E+ Q+E A +Q EE + + E E + A +E EAE+G
Sbjct: 2536 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2595
Query: 62 ESKPKPRSFMPNLVPPKIPDGERVDFDDIHRKRMEKDLNELQALIEAHFENRKKEEEELV 121
+ + + + +R +++ + ++ +LQ L E H EE
Sbjct: 2596 KQEELQQL-----------EQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2644
Query: 122 SL----------KDRIERRRAERAEQQRIRNEREKERQNRLAEERARREEEENR 165
S +D ++ AE + R K RL E EE R
Sbjct: 2645 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2698
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.124 0.323
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,135,893
Number of Sequences: 37866
Number of extensions: 636843
Number of successful extensions: 43817
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1304
Number of HSP's successfully gapped in prelim test: 1212
Number of HSP's that attempted gapping in prelim test: 7386
Number of HSP's gapped (non-prelim): 14468
length of query: 285
length of database: 18,247,518
effective HSP length: 101
effective length of query: 184
effective length of database: 14,423,052
effective search space: 2653841568
effective search space used: 2653841568
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.