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Search of human proteins with 47933346
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47933346 zinc finger, DHHC domain containing 13 isoform 1
[Homo sapiens]
(622 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47933346 zinc finger, DHHC domain containing 13 isoform 1 [Ho... 1296 0.0
gi|47933348 zinc finger, DHHC domain containing 13 isoform 2 [Ho... 1023 0.0
gi|103471993 huntingtin interacting protein 14 [Homo sapiens] 617 e-177
gi|30348954 mindbomb homolog 1 [Homo sapiens] 90 5e-18
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 90 7e-18
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 90 7e-18
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 89 9e-18
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 89 9e-18
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 89 9e-18
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 89 9e-18
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 89 9e-18
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 87 5e-17
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 86 1e-16
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 85 2e-16
gi|90186267 ankyrin repeat domain 55 isoform 1 [Homo sapiens] 85 2e-16
gi|37594451 Abl-philin 2 isoform 2 [Homo sapiens] 84 4e-16
gi|37594449 Abl-philin 2 isoform 1 [Homo sapiens] 83 9e-16
gi|37594455 Abl-philin 2 isoform 1 [Homo sapiens] 83 9e-16
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 82 1e-15
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 82 2e-15
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 82 2e-15
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 82 2e-15
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 81 3e-15
gi|134133226 protein expressed in prostate, ovary, testis, and p... 81 3e-15
gi|209977003 ANKRD26-like family C, member 3 [Homo sapiens] 81 3e-15
gi|153791352 prostate, ovary, testis expressed protein on chromo... 81 3e-15
gi|224282147 prostate-specific P704P [Homo sapiens] 80 4e-15
gi|37594447 Abl-philin 2 isoform 4 [Homo sapiens] 80 4e-15
gi|113413200 PREDICTED: similar to protein expressed in prostate... 80 6e-15
gi|239741769 PREDICTED: similar to protein expressed in prostate... 80 6e-15
>gi|47933346 zinc finger, DHHC domain containing 13 isoform 1 [Homo
sapiens]
Length = 622
Score = 1296 bits (3354), Expect = 0.0
Identities = 622/622 (100%), Positives = 622/622 (100%)
Query: 1 MEGPGLGSQCRNHSHGPHPPGFGRYGICAHENKELANAREALPLIEDSSNCDIVKATQYG 60
MEGPGLGSQCRNHSHGPHPPGFGRYGICAHENKELANAREALPLIEDSSNCDIVKATQYG
Sbjct: 1 MEGPGLGSQCRNHSHGPHPPGFGRYGICAHENKELANAREALPLIEDSSNCDIVKATQYG 60
Query: 61 IFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPL 120
IFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPL
Sbjct: 61 IFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPL 120
Query: 121 HWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDV 180
HWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDV
Sbjct: 121 HWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDV 180
Query: 181 NGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAG 240
NGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAG
Sbjct: 181 NGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAG 240
Query: 241 SSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLWRWLQKCELFLLLMLSV 300
SSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLWRWLQKCELFLLLMLSV
Sbjct: 241 SSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLWRWLQKCELFLLLMLSV 300
Query: 301 ITMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIF 360
ITMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIF
Sbjct: 301 ITMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIF 360
Query: 361 MTWFILFFPDLAGAPFYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETG 420
MTWFILFFPDLAGAPFYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETG
Sbjct: 361 MTWFILFFPDLAGAPFYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETG 420
Query: 421 SLDFRTFCTSCLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSM 480
SLDFRTFCTSCLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSM
Sbjct: 421 SLDFRTFCTSCLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSM 480
Query: 481 VCGWIIYGSFIYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLN 540
VCGWIIYGSFIYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLN
Sbjct: 481 VCGWIIYGSFIYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLN 540
Query: 541 QLFQIAFLGLTSHERISLQKQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCV 600
QLFQIAFLGLTSHERISLQKQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCV
Sbjct: 541 QLFQIAFLGLTSHERISLQKQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCV 600
Query: 601 VDWTSQYTMVFHPAREKVLRSV 622
VDWTSQYTMVFHPAREKVLRSV
Sbjct: 601 VDWTSQYTMVFHPAREKVLRSV 622
>gi|47933348 zinc finger, DHHC domain containing 13 isoform 2 [Homo
sapiens]
Length = 492
Score = 1023 bits (2644), Expect = 0.0
Identities = 492/492 (100%), Positives = 492/492 (100%)
Query: 131 MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSA 190
MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSA
Sbjct: 1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSA 60
Query: 191 HKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKG 250
HKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKG
Sbjct: 61 HKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKG 120
Query: 251 ETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLWRWLQKCELFLLLMLSVITMWAIGYIL 310
ETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLWRWLQKCELFLLLMLSVITMWAIGYIL
Sbjct: 121 ETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLWRWLQKCELFLLLMLSVITMWAIGYIL 180
Query: 311 DFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIFMTWFILFFPD 370
DFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIFMTWFILFFPD
Sbjct: 181 DFNSDSWLLKGCLLVTLFFLTSLFPRFLVGYKNLVYLPTAFLLSSVFWIFMTWFILFFPD 240
Query: 371 LAGAPFYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFRTFCTS 430
LAGAPFYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFRTFCTS
Sbjct: 241 LAGAPFYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFRTFCTS 300
Query: 431 CLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSF 490
CLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSF
Sbjct: 301 CLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSF 360
Query: 491 IYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAFLGL 550
IYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAFLGL
Sbjct: 361 IYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLNQLFQIAFLGL 420
Query: 551 TSHERISLQKQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCVVDWTSQYTMV 610
TSHERISLQKQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCVVDWTSQYTMV
Sbjct: 421 TSHERISLQKQSKHMKQTLSLRKTPYNLGFMQNLADFFQCGCFGLVKPCVVDWTSQYTMV 480
Query: 611 FHPAREKVLRSV 622
FHPAREKVLRSV
Sbjct: 481 FHPAREKVLRSV 492
Score = 34.3 bits (77), Expect = 0.35
Identities = 31/135 (22%), Positives = 56/135 (41%), Gaps = 34/135 (25%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVD------------------ 109
L++ G D D E S +H A + + ++ + ISKG V+
Sbjct: 5 LLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVI 64
Query: 110 ---------QLGGDLN-------STPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSI 153
+ LN +TPLHWA+ G++ V LL+ G+ + + +G + +
Sbjct: 65 GPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPL 124
Query: 154 HLAVLFQHMPIIAYL 168
+A+ ++ II L
Sbjct: 125 DMALQNKNQLIIHML 139
>gi|103471993 huntingtin interacting protein 14 [Homo sapiens]
Length = 632
Score = 617 bits (1592), Expect = e-177
Identities = 291/570 (51%), Positives = 396/570 (69%), Gaps = 4/570 (0%)
Query: 45 IEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISK 104
I+D S DIVKATQYGI+ERC+ELVEAGYDVRQPDKENV+LLHWAAINNR+DLVK+YISK
Sbjct: 53 IDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISK 112
Query: 105 GAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPI 164
GA+VDQLGGDLNSTPLHWA RQGHL MV+ L+++GADP+LIDGEG S IHLA F H I
Sbjct: 113 GAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSI 172
Query: 165 IAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWA 224
+AYLI+KGQ V+M D NG TPLM +A++ +PT LL FN S+N+ DK H+NT LHWA
Sbjct: 173 VAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWA 232
Query: 225 VAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRANQKFRLW 284
V AGN + LLEAG+++D QN+KGE+ LD+A Q KN +I+ L+ + +
Sbjct: 233 VLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFL 292
Query: 285 RWLQKCELF---LLLMLSVITMWAIGYILDFNSDSWLLKGCLLVTLFFLTSLFPRFLVGY 341
R L+ + F ++L + +W +G+I D N DSWL+KG + ++ + +
Sbjct: 293 RKLKADKEFRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDH 352
Query: 342 KNLVYLPTAFLLSSVFWIFMTWFILFFPDLAGAPFYFSFIFSIVAFLYFFYKTWATDPGF 401
LP L++ FW+++TWF F+ DL + F+ + VA Y F K+W +DPG
Sbjct: 353 SMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGI 412
Query: 402 TKASEEEKKVNIITLAETGSLDFRTFCTSCLIRKPLRSLHCHVCNCCVARYDQHCLWTGR 461
KA+EE+KK I+ LAETGSLD FC++CLIRKP+RS HC VCN C+A++D HC W G
Sbjct: 413 IKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGN 472
Query: 462 CIGFGNHHYYIFFLFFLSMVCGWIIYGSFIYLSSHCATTFKEDGLWTYLNQIVACSPWVL 521
C+G GNH Y++ +LFFL + W+IYG Y HC TT+ +DG WTY+ QI CSPW+
Sbjct: 473 CVGAGNHRYFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMF 532
Query: 522 YILMLATFHFSWSTFLLLNQLFQIAFLGLTSHERISLQKQSKHMKQTLSLRKTPYNLGFM 581
++ + + FHF W LL+ Q++QI+ LG+T++ER++ ++ KH K T + ++P+N G +
Sbjct: 533 WMFLNSVFHFMWVAVLLMCQMYQISCLGITTNERMNARRY-KHFKVTTTSIESPFNHGCV 591
Query: 582 QNLADFFQCGCFGLVKPCVVDWTSQYTMVF 611
+N+ DFF+ C GL +P +VDWT QYT+ +
Sbjct: 592 RNIIDFFEFRCCGLFRPVIVDWTRQYTIEY 621
Score = 46.2 bits (108), Expect = 9e-05
Identities = 34/128 (26%), Positives = 63/128 (49%), Gaps = 2/128 (1%)
Query: 43 PLIEDSSNCDIVK-ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAI-NNRLDLVKF 100
P + D C + A Q+G L+ G DV D+ ++ L WAA + +D +
Sbjct: 150 PSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRL 209
Query: 101 YISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQ 160
++ V+ +T LHWA+ G+ ++ LLL+ GA+ + +G S++ LA +
Sbjct: 210 LLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRK 269
Query: 161 HMPIIAYL 168
++ +I +L
Sbjct: 270 NVWMINHL 277
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 90.1 bits (222), Expect = 5e-18
Identities = 75/238 (31%), Positives = 118/238 (49%), Gaps = 24/238 (10%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQL---G 112
A+Q G + K L++ DV DK+ +H AA + +GAV++ L
Sbjct: 471 ASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGD----------EGAVIEVLHRGS 520
Query: 113 GDLNS------TPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIA 166
DLN+ TPLH A+ +GHL +V LL G P+L D EG + +H A+ + I+A
Sbjct: 521 ADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILA 580
Query: 167 YLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQN--TPLHWA 224
L+ G V +T+ NG L +A + P LL P +VD+ + T LH A
Sbjct: 581 VLLEAGADVTITNNNGFNALHHAALRG-NPSAMRVLLSKLPRPWIVDEKKDDGYTALHLA 639
Query: 225 VAAGNVNAVDKLLEAG-SSLDIQNVKGETPLDMALQNKNQLIIHML-KTEAKMRANQK 280
+V + L+ G ++LDIQNV +T L +A++ ++ I+ +L + AK+ K
Sbjct: 640 ALNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDK 697
Score = 60.1 bits (144), Expect = 6e-09
Identities = 56/203 (27%), Positives = 92/203 (45%), Gaps = 19/203 (9%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGA---VVDQLGGDLNSTPLHWAI 124
L+EAG DV + + LH AA+ ++ +SK +VD+ D T LH A
Sbjct: 582 LLEAGADVTITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDD-GYTALHLAA 640
Query: 125 RQGHLPMVILLLQHG-ADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQ 183
H+ + LL+ G A+ + + +++HLAV QH I+ L+ G +++ D +G
Sbjct: 641 LNNHVEVAELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGD 700
Query: 184 TPLMLSAHKVIGPEPTGFLLKFNPSLNV--VDKIHQNTPLHWAVAAGNVNAVDK------ 235
TPL H+ + L + +V VD + + + G A K
Sbjct: 701 TPL----HEALRHHTLSQLRQLQDMQDVGKVDAAWEPSKNTLIMGLGTQGAEKKSAASIA 756
Query: 236 --LLEAGSSLDIQNVKGETPLDM 256
L G+ L I+N KG++PLD+
Sbjct: 757 CFLAANGADLSIRNKKGQSPLDL 779
Score = 52.0 bits (123), Expect = 2e-06
Identities = 54/207 (26%), Positives = 92/207 (44%), Gaps = 4/207 (1%)
Query: 63 ERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHW 122
ER +L++ ++ ++ N L+ AA N + V+ + K VD G T +
Sbjct: 413 ERLSQLLKKLFETQESGDLNEELVK-AAANGDVAKVEDLL-KRPDVDVNGQCAGHTAMQA 470
Query: 123 AIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNG 182
A + GH+ ++ LLL+ D D +G ++H A +I L +N +
Sbjct: 471 ASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRR 530
Query: 183 QTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSS 242
QTPL ++ +K + LL F ++ D +TPLH A++ + + LLEAG+
Sbjct: 531 QTPLHIAVNKG-HLQVVKTLLDFGCHPSLQDS-EGDTPLHDAISKKRDDILAVLLEAGAD 588
Query: 243 LDIQNVKGETPLDMALQNKNQLIIHML 269
+ I N G L A N + +L
Sbjct: 589 VTITNNNGFNALHHAALRGNPSAMRVL 615
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 89.7 bits (221), Expect = 7e-18
Identities = 73/252 (28%), Positives = 114/252 (45%), Gaps = 14/252 (5%)
Query: 29 AHENKELANAREALPLIEDSSNCD------IVKATQYGIFERCKELVEAGYDVRQPDKEN 82
A NK + A +PL+ + D + A G E L+ G ++ DK++
Sbjct: 89 AAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKD 148
Query: 83 VSLLHWAAINNRLDLVKFYISKGAVV---DQLGGDLNSTPLHWAIRQGHLPMVILLLQHG 139
LHWAA LD+V I+ GA V D+ G TPLH A G + +V LL G
Sbjct: 149 RRALHWAAYMGHLDVVALLINHGAEVTCKDKKG----YTPLHAAASNGQINVVKHLLNLG 204
Query: 140 ADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPT 199
+ I+ G +++H+A ++ LI G +VN + NG TPL +A G
Sbjct: 205 VEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCL 264
Query: 200 GFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQ 259
L+ +N+ K +PLH G L++ G +D + G TPL +A +
Sbjct: 265 ELLVNNGADVNIQSK-DGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAAR 323
Query: 260 NKNQLIIHMLKT 271
++L+I+ L+T
Sbjct: 324 YGHELLINTLRT 335
Score = 70.1 bits (170), Expect = 6e-12
Identities = 60/223 (26%), Positives = 107/223 (47%), Gaps = 14/223 (6%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A G + + L+++ D+ D++ + L AA + V+ I+ GA +
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLI---DGEGFSSIHLAVLFQHMPIIAYLISKG 172
TPLH ++ GH + LLL+ +P + D +G + + LAV + H+ ++ L+ K
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668
Query: 173 QSVNMTDVNGQTPL---MLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGN 229
+V+ D+ G T L +++ H+ E LL+ S+ D TPLH+A A G+
Sbjct: 669 ANVDTVDILGCTALHRGIMTGHE----ECVQMLLEQEVSILCKDS-RGRTPLHYAAARGH 723
Query: 230 VNAVDKLLEAGSSLD---IQNVKGETPLDMALQNKNQLIIHML 269
+ +LL+ S + ++ +G TPL A N N+ I +L
Sbjct: 724 ATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
Score = 69.7 bits (169), Expect = 8e-12
Identities = 59/209 (28%), Positives = 81/209 (38%), Gaps = 40/209 (19%)
Query: 63 ERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYIS--KGAVVDQLGGDLNSTPL 120
E + L++ DV DK + LH AA N + + I V GG T L
Sbjct: 63 EAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG---RTAL 119
Query: 121 HWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDV 180
H A GH+ MV LLL GA+ D + ++H A H+ ++A LI+ G V D
Sbjct: 120 HHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDK 179
Query: 181 NGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAG 240
G TPL H A + G +N V LL G
Sbjct: 180 KGYTPL-----------------------------------HAAASNGQINVVKHLLNLG 204
Query: 241 SSLDIQNVKGETPLDMALQNKNQLIIHML 269
+D NV G T L +A N +++ L
Sbjct: 205 VEIDEINVYGNTALHIACYNGQDAVVNEL 233
Score = 68.9 bits (167), Expect = 1e-11
Identities = 58/213 (27%), Positives = 97/213 (45%), Gaps = 7/213 (3%)
Query: 67 ELVEAGYDVRQPDKENVSLLHWAAINNRLDL-VKFYISKGAVVDQLGGDLNSTPLHWAIR 125
EL++ G +V QP+ + LH+AA + L ++ ++ GA V+ D +PLH
Sbjct: 232 ELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKD-GKSPLHMTAV 290
Query: 126 QGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTP 185
G L+Q+G + +D +G + +H+A + H +I L + G ++ P
Sbjct: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP 350
Query: 186 LMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDI 245
L L+A + LL ++ DK + T LH A A GNV + L +G+
Sbjct: 351 LHLAALNAHS-DCCRKLLSSGFEIDTPDKFGR-TCLHAAAAGGNVECIKLLQSSGADFHK 408
Query: 246 QNVKGETPLDMALQNKNQLIIHMLKTEAKMRAN 278
++ G TPL A N + H ++T AN
Sbjct: 409 KDKCGRTPLHYAAANCH---FHCIETLVTTGAN 438
Score = 67.8 bits (164), Expect = 3e-11
Identities = 57/190 (30%), Positives = 84/190 (44%), Gaps = 3/190 (1%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQG 127
LV G DV K+ S LH A++ R + I G +D + D N TPLH A R G
Sbjct: 267 LVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGN-TPLHVAARYG 325
Query: 128 HLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLM 187
H ++ L GAD +HLA L H L+S G ++ D G+T L
Sbjct: 326 HELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLH 385
Query: 188 LSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQN 247
+A E L + DK + TPLH+A A + + ++ L+ G++++ +
Sbjct: 386 AAAAGG-NVECIKLLQSSGADFHKKDKCGR-TPLHYAAANCHFHCIETLVTTGANVNETD 443
Query: 248 VKGETPLDMA 257
G T L A
Sbjct: 444 DWGRTALHYA 453
Score = 65.1 bits (157), Expect = 2e-10
Identities = 54/198 (27%), Positives = 94/198 (47%), Gaps = 11/198 (5%)
Query: 79 DKENVSLLHWAAINNRLDLVKFYISK-GAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQ 137
DKE + +H+AA ++ + + + ++ +PLH A GH + +LLQ
Sbjct: 504 DKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQ 563
Query: 138 HGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTD-VNGQTPL---MLSAHKV 193
D + D +G +++ LA H + LI+ G S+ + D V +TPL +++ H +
Sbjct: 564 SLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTL 623
Query: 194 IGPEPTGFLLKF--NPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGE 251
LL+ NP V TPL AVA G+++AV LLE +++D ++ G
Sbjct: 624 C----LRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGC 679
Query: 252 TPLDMALQNKNQLIIHML 269
T L + ++ + ML
Sbjct: 680 TALHRGIMTGHEECVQML 697
Score = 62.4 bits (150), Expect = 1e-09
Identities = 64/265 (24%), Positives = 110/265 (41%), Gaps = 68/265 (25%)
Query: 60 GIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTP 119
G E K L +G D + DK + LH+AA N ++ ++ GA V++ D T
Sbjct: 391 GNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETD-DWGRTA 449
Query: 120 LHWA---------------------------IRQGHLPMVI-LLLQHGADPTLIDGEGFS 151
LH+A +++ + + LLQ+ A+P++ D EG++
Sbjct: 450 LHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYN 509
Query: 152 SIHLAVLFQHMPIIAYLISKGQS-----------------------------------VN 176
SIH A + H + L+ + S ++
Sbjct: 510 SIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLD 569
Query: 177 MTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKL 236
+ D G+T L L+A K E L+ S+ V D + + TPLH +V G+ + L
Sbjct: 570 IRDEKGRTALDLAAFKG-HTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLL 628
Query: 237 LEAG---SSLDIQNVKGETPLDMAL 258
LE ++D+++ KG+TPL +A+
Sbjct: 629 LEIADNPEAVDVKDAKGQTPLMLAV 653
Score = 57.4 bits (137), Expect = 4e-08
Identities = 38/122 (31%), Positives = 60/122 (49%), Gaps = 1/122 (0%)
Query: 118 TPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNM 177
TPL A+ GH+ V LLL+ A+ +D G +++H ++ H + L+ + S+
Sbjct: 647 TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILC 706
Query: 178 TDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQN-TPLHWAVAAGNVNAVDKL 236
D G+TPL +A + + L + K +Q TPLHWA GN N ++ L
Sbjct: 707 KDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
Query: 237 LE 238
LE
Sbjct: 767 LE 768
Score = 56.2 bits (134), Expect = 9e-08
Identities = 64/254 (25%), Positives = 105/254 (41%), Gaps = 31/254 (12%)
Query: 45 IEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISK 104
++ N + A +YG L +G D + ++ LH AA+N D + +S
Sbjct: 310 VDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSS 369
Query: 105 GAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPI 164
G +D T LH A G++ + LL GAD D G + +H A H
Sbjct: 370 GFEIDT-PDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHC 428
Query: 165 IAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPT------------------------- 199
I L++ G +VN TD G+T L +A + T
Sbjct: 429 IETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATL 488
Query: 200 --GFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGET--PLD 255
FLL+ + + ++ DK N+ +H+A A G+ ++ LLE +S ++ G T PL
Sbjct: 489 CLEFLLQNDANPSIRDKEGYNS-IHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLH 547
Query: 256 MALQNKNQLIIHML 269
+A N + + +L
Sbjct: 548 LAAYNGHHQALEVL 561
Score = 49.3 bits (116), Expect = 1e-05
Identities = 40/139 (28%), Positives = 63/139 (45%), Gaps = 8/139 (5%)
Query: 134 LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKV 193
+L+ D +D E + +H+A II LI G VN D TPL H+
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPL----HRA 56
Query: 194 I---GPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKG 250
+ E L+K + +N DK Q TPLH A A V + ++ SS+++ + G
Sbjct: 57 VASRSEEAVQVLIKHSADVNARDKNWQ-TPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 115
Query: 251 ETPLDMALQNKNQLIIHML 269
T L A N + ++++L
Sbjct: 116 RTALHHAALNGHVEMVNLL 134
Score = 45.4 bits (106), Expect = 2e-04
Identities = 58/263 (22%), Positives = 103/263 (39%), Gaps = 11/263 (4%)
Query: 18 HPPGFGRYGICAHENKELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQ 77
H + +C E+A+ EA+ + + ++ A YG + L+E +V
Sbjct: 614 HASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDT 673
Query: 78 PDKENVSLLHWAAINNRLDLVKFYISKGAVV---DQLGGDLNSTPLHWAIRQGHLPMVIL 134
D + LH + + V+ + + + D G TPLH+A +GH +
Sbjct: 674 VDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRG----RTPLHYAAARGHATWLSE 729
Query: 135 LLQHGA---DPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAH 191
LLQ D D +G++ +H A + I L+ + + N TPL +
Sbjct: 730 LLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQ-KCFRKFIGNPFTPLHCAII 788
Query: 192 KVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGE 251
G + L + S+ TPL A A +V + LL + ++ + G+
Sbjct: 789 NDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGK 848
Query: 252 TPLDMALQNKNQLIIHMLKTEAK 274
T L MA +N + +L A+
Sbjct: 849 TALMMAAENGQAGAVDILVNSAQ 871
Score = 34.7 bits (78), Expect = 0.27
Identities = 29/111 (26%), Positives = 50/111 (45%), Gaps = 6/111 (5%)
Query: 86 LHWAAINNRLDLVKFYISKGAVVDQLGG---DLNSTPLHWAIRQGHLPMVILLLQHGADP 142
LH A IN+ + + GA+ + D TPL A H+ + LLL+H A
Sbjct: 783 LHCAIINDHGNCASLLL--GAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPV 840
Query: 143 TLIDGEGFSSIHLAVLFQHMPIIAYLISKGQS-VNMTDVNGQTPLMLSAHK 192
+D G +++ +A + L++ Q+ + + D + TPL L+ K
Sbjct: 841 NAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSK 891
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 89.7 bits (221), Expect = 7e-18
Identities = 70/245 (28%), Positives = 119/245 (48%), Gaps = 12/245 (4%)
Query: 34 ELANAREALPLIEDSSNCDI---------VKATQYGIFERCKELVEAGYDVRQPDKENVS 84
E N LI++ +NC++ + A++ G +EL++ G ++ D +
Sbjct: 47 EQGNLEIVKELIKNGANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWT 106
Query: 85 LLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTL 144
L WA R D+V+ +S GA + G + P+ WA +GH +V LLLQ+GA
Sbjct: 107 ALMWACYKGRTDVVELLLSHGAN-PSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNC 165
Query: 145 IDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLK 204
D G + + A H+ + +L++ G V+ N T L++ A K + +LK
Sbjct: 166 SDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIV-AVKGGYTQSVKEILK 224
Query: 205 FNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQL 264
NP++N+ DK NT L A G+ V LL+AG+ ++I + G+T L A++ +
Sbjct: 225 RNPNVNLTDK-DGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVE 283
Query: 265 IIHML 269
I+ L
Sbjct: 284 IVRAL 288
Score = 78.2 bits (191), Expect = 2e-14
Identities = 63/214 (29%), Positives = 108/214 (50%), Gaps = 4/214 (1%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQG 127
L++ G V DK + L WAA L+ VK ++ GA VDQ G + + T L A++ G
Sbjct: 156 LLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGAN-SMTALIVAVKGG 214
Query: 128 HLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLM 187
+ V +L+ + L D +G +++ +A H I+ L+ G VN+ D +G T ++
Sbjct: 215 YTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDT-VL 273
Query: 188 LSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQN 247
+ A + E LL+ +++ + ++ T L+WAV GN V +L+ +I
Sbjct: 274 IGAVRGGHVEIVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVRDILQCNPDTEICT 332
Query: 248 VKGETPLDMALQNKNQLIIHMLKTE-AKMRANQK 280
GETPL A + +N ++ +L + AK+ A K
Sbjct: 333 KDGETPLIKATKMRNIEVVELLLDKGAKVSAVDK 366
Score = 70.9 bits (172), Expect = 3e-12
Identities = 43/157 (27%), Positives = 81/157 (51%), Gaps = 1/157 (0%)
Query: 33 KELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAIN 92
KE+ + L + N ++ A++ G E ++L++AG V PD+ ++L A
Sbjct: 220 KEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRG 279
Query: 93 NRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSS 152
+++V+ + K A +D G D N T L+WA+ +G+ MV +LQ D + +G +
Sbjct: 280 GHVEIVRALLQKYADIDIRGQD-NKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETP 338
Query: 153 IHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLS 189
+ A +++ ++ L+ KG V+ D G TPL ++
Sbjct: 339 LIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIA 375
Score = 57.4 bits (137), Expect = 4e-08
Identities = 47/173 (27%), Positives = 87/173 (50%), Gaps = 4/173 (2%)
Query: 98 VKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAV 157
+K + K VD+ + TPL A QG+L +V L+++GA+ L D + ++++ A
Sbjct: 21 LKALLEKCKDVDERN-ECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALISAS 79
Query: 158 LFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQ 217
H+ I+ L+ G ++ D+ G T LM + +K G LL + + V ++
Sbjct: 80 KEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYK--GRTDVVELLLSHGANPSVTGLYS 137
Query: 218 NTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKN-QLIIHML 269
P+ WA G+ + V LL+ G+ ++ + G TPL A + + + + H+L
Sbjct: 138 VYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLL 190
Score = 39.3 bits (90), Expect = 0.011
Identities = 31/110 (28%), Positives = 59/110 (53%), Gaps = 2/110 (1%)
Query: 160 QHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNT 219
+++P + L+ K + V+ + GQTPLM++A + E L+K + N+ D + T
Sbjct: 16 ENIPALKALLEKCKDVDERNECGQTPLMIAAEQG-NLEIVKELIKNGANCNLED-LDNWT 73
Query: 220 PLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
L A G+V+ V++LL+ G +L+ +++ G T L A ++ +L
Sbjct: 74 ALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELL 123
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 89.4 bits (220), Expect = 9e-18
Identities = 67/246 (27%), Positives = 115/246 (46%), Gaps = 35/246 (14%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQL---------------- 111
L++ G ++ K +S +H AA + LD V+ + A +D +
Sbjct: 324 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 383
Query: 112 ----------GGDLNS------TPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHL 155
G NS TPLH A ++ H+ ++ LLL+ GA + G + +H+
Sbjct: 384 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 443
Query: 156 AVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKI 215
A H+PI+ L+ +G S N+++V +TPL ++A + E +LL+ +N K
Sbjct: 444 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA-RAGHTEVAKYLLQNKAKVNAKAKD 502
Query: 216 HQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKN-QLIIHMLKTEAK 274
Q TPLH A G+ N V LLE ++ ++ G TPL +A + + + ++ +L+ EA
Sbjct: 503 DQ-TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 561
Query: 275 MRANQK 280
K
Sbjct: 562 QACMTK 567
Score = 87.4 bits (215), Expect = 4e-17
Identities = 78/286 (27%), Positives = 129/286 (45%), Gaps = 44/286 (15%)
Query: 37 NAREALPLIEDSSNCDIVKAT---------QYGIFERCKELVEAGYDVRQPDKENVSLLH 87
+ R A L+++ N D++ T Y + L+ G V + ++ LH
Sbjct: 218 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 277
Query: 88 WAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDG 147
A+ + +V+ + +GA ++ D TPLH A R GH+ + +LL HGA
Sbjct: 278 IASRRGNVIMVRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAPIQAKTK 336
Query: 148 EGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAH-------KVI---GPE 197
G S IH+A H+ + L+ ++ ++ TPL ++AH KV+ G +
Sbjct: 337 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 396
Query: 198 P-----TGF-----------------LLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDK 235
P GF LLK S++ V + TPLH A G++ V
Sbjct: 397 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE-SGLTPLHVASFMGHLPIVKN 455
Query: 236 LLEAGSSLDIQNVKGETPLDMALQ-NKNQLIIHMLKTEAKMRANQK 280
LL+ G+S ++ NVK ETPL MA + ++ ++L+ +AK+ A K
Sbjct: 456 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 501
Score = 83.2 bits (204), Expect = 7e-16
Identities = 71/235 (30%), Positives = 106/235 (45%), Gaps = 26/235 (11%)
Query: 29 AHENKELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHW 88
AH N N L + +N DIVK L+ G P + LH
Sbjct: 593 AHPNAAGKNGLTPLHVAVHHNNLDIVKL-----------LLPRGGSPHSPAWNGYTPLHI 641
Query: 89 AAINNRLDLVKFYISKGAVVDQLGGDLNS------TPLHWAIRQGHLPMVILLLQHGADP 142
AA N++++ + + Q GG N+ TPLH A ++GH MV LLL A+
Sbjct: 642 AAKQNQVEVARSLL-------QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694
Query: 143 TLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFL 202
L + G + +HL H+P+ LI G V+ T G TPL +++H + FL
Sbjct: 695 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH-YGNIKLVKFL 753
Query: 203 LKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMA 257
L+ +N K+ +PLH A G+ + V LL+ G+S + + G TPL +A
Sbjct: 754 LQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807
Score = 81.3 bits (199), Expect = 3e-15
Identities = 71/267 (26%), Positives = 119/267 (44%), Gaps = 36/267 (13%)
Query: 34 ELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINN 93
EL + L N + A G E +ELV G +V ++ + L+ AA N
Sbjct: 96 ELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 155
Query: 94 RLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVI-------------------- 133
L++VKF + GA + D TPL A++QGH +V
Sbjct: 156 HLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA 214
Query: 134 ---------LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQT 184
+LLQ+ +P ++ GF+ +H+A ++++ + L+++G SVN T NG T
Sbjct: 215 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 274
Query: 185 PLMLSAHK--VIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSS 242
PL +++ + VI LL + K + TPLH A G+V + LL+ G+
Sbjct: 275 PLHIASRRGNVI---MVRLLLDRGAQIETKTK-DELTPLHCAARNGHVRISEILLDHGAP 330
Query: 243 LDIQNVKGETPLDMALQNKNQLIIHML 269
+ + G +P+ MA Q + + +L
Sbjct: 331 IQAKTKNGLSPIHMAAQGDHLDCVRLL 357
Score = 79.0 bits (193), Expect = 1e-14
Identities = 62/215 (28%), Positives = 102/215 (47%), Gaps = 5/215 (2%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A +YG + L+E K ++ LH A +N LD+VK + +G +
Sbjct: 576 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN- 634
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A +Q + + LLQ+G +G + +HLA H ++A L+SK +
Sbjct: 635 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694
Query: 176 NMTDVNGQTPLMLSAHKVIGPEPTG-FLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVD 234
N+ + +G TPL L A + G P L+K ++ ++ TPLH A GN+ V
Sbjct: 695 NLGNKSGLTPLHLVAQE--GHVPVADVLIKHGVMVDATTRMGY-TPLHVASHYGNIKLVK 751
Query: 235 KLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
LL+ + ++ + G +PL A Q + I+ +L
Sbjct: 752 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 786
Score = 78.2 bits (191), Expect = 2e-14
Identities = 61/221 (27%), Positives = 101/221 (45%), Gaps = 17/221 (7%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A + G E K L++ V K++ + LH AA ++VK + A + L
Sbjct: 477 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN-LATTA 535
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A R+GH+ V+ LL+ A + +GF+ +H+A + + + L+ +
Sbjct: 536 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 595
Query: 176 NMTDVNGQTPLMLSAH-------KVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAG 228
N NG TPL ++ H K++ P +P+ N TPLH A
Sbjct: 596 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS---PHSPAWN------GYTPLHIAAKQN 646
Query: 229 NVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
V LL+ G S + ++V+G TPL +A Q + ++ +L
Sbjct: 647 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 687
Score = 73.6 bits (179), Expect = 5e-13
Identities = 64/226 (28%), Positives = 102/226 (45%), Gaps = 4/226 (1%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A + G E L+E K+ + LH AA ++ + + + + A + G +
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 601
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A+ +L +V LLL G P G++ +H+A + + L+ G S
Sbjct: 602 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 661
Query: 176 NMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDK 235
N V G TPL L+A + E LL + N+ +K TPLH G+V D
Sbjct: 662 NAESVQGVTPLHLAAQEGHA-EMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVADV 719
Query: 236 LLEAGSSLDIQNVKGETPLDMALQNKN-QLIIHMLKTEAKMRANQK 280
L++ G +D G TPL +A N +L+ +L+ +A + A K
Sbjct: 720 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK 765
Score = 67.0 bits (162), Expect = 5e-11
Identities = 53/202 (26%), Positives = 86/202 (42%), Gaps = 3/202 (1%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQG 127
L++ G + + ++ LH A+ L +VK + +GA + TPLH A R G
Sbjct: 423 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAG 481
Query: 128 HLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLM 187
H + LLQ+ A + + +H A H ++ L+ + N+ G TPL
Sbjct: 482 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLH 541
Query: 188 LSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQN 247
++A + G T L + TPLH A G V + LLE + +
Sbjct: 542 IAARE--GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 599
Query: 248 VKGETPLDMALQNKNQLIIHML 269
G TPL +A+ + N I+ +L
Sbjct: 600 KNGLTPLHVAVHHNNLDIVKLL 621
Score = 52.8 bits (125), Expect = 1e-06
Identities = 43/158 (27%), Positives = 79/158 (50%), Gaps = 7/158 (4%)
Query: 123 AIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNG 182
A R G+L + L++G D + G + +HLA H+ ++ L+ K + T G
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111
Query: 183 QTPLMLSAHKVIG-PEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGS 241
T L ++A + G E L+ + ++N + TPL+ A ++ V LLE G+
Sbjct: 112 NTALHIAA--LAGQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENGA 168
Query: 242 SLDIQNVKGETPLDMALQNKNQ-LIIHMLK--TEAKMR 276
+ ++ G TPL +ALQ ++ ++ H++ T+ K+R
Sbjct: 169 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 206
Score = 52.0 bits (123), Expect = 2e-06
Identities = 57/243 (23%), Positives = 99/243 (40%), Gaps = 65/243 (26%)
Query: 89 AAINNRLDLVKFYISKGAVVDQLGGD-LNSTPLHWAIRQGHLPMVILLL----------- 136
AA + LD ++ G ++ + LN LH A ++GH+ MV+ LL
Sbjct: 52 AARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEIILETTTK 109
Query: 137 ----------------------QHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQS 174
+GA+ +GF+ +++A H+ ++ +L+ G +
Sbjct: 110 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 169
Query: 175 VNMTDVNGQTPLMLS---------AH--------KVIGP-----------EPTGFLLKFN 206
N+ +G TPL ++ AH KV P LL+ +
Sbjct: 170 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 229
Query: 207 PSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLII 266
P+ +V+ K TPLH A N+N LL G+S++ G TPL +A + N +++
Sbjct: 230 PNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 288
Query: 267 HML 269
+L
Sbjct: 289 RLL 291
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 89.4 bits (220), Expect = 9e-18
Identities = 67/246 (27%), Positives = 115/246 (46%), Gaps = 35/246 (14%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQL---------------- 111
L++ G ++ K +S +H AA + LD V+ + A +D +
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
Query: 112 ----------GGDLNS------TPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHL 155
G NS TPLH A ++ H+ ++ LLL+ GA + G + +H+
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410
Query: 156 AVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKI 215
A H+PI+ L+ +G S N+++V +TPL ++A + E +LL+ +N K
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA-RAGHTEVAKYLLQNKAKVNAKAKD 469
Query: 216 HQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKN-QLIIHMLKTEAK 274
Q TPLH A G+ N V LLE ++ ++ G TPL +A + + + ++ +L+ EA
Sbjct: 470 DQ-TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 275 MRANQK 280
K
Sbjct: 529 QACMTK 534
Score = 87.4 bits (215), Expect = 4e-17
Identities = 78/286 (27%), Positives = 129/286 (45%), Gaps = 44/286 (15%)
Query: 37 NAREALPLIEDSSNCDIVKAT---------QYGIFERCKELVEAGYDVRQPDKENVSLLH 87
+ R A L+++ N D++ T Y + L+ G V + ++ LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 88 WAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDG 147
A+ + +V+ + +GA ++ D TPLH A R GH+ + +LL HGA
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 148 EGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAH-------KVI---GPE 197
G S IH+A H+ + L+ ++ ++ TPL ++AH KV+ G +
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 198 P-----TGF-----------------LLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDK 235
P GF LLK S++ V + TPLH A G++ V
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE-SGLTPLHVASFMGHLPIVKN 422
Query: 236 LLEAGSSLDIQNVKGETPLDMALQ-NKNQLIIHMLKTEAKMRANQK 280
LL+ G+S ++ NVK ETPL MA + ++ ++L+ +AK+ A K
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 468
Score = 83.2 bits (204), Expect = 7e-16
Identities = 71/235 (30%), Positives = 106/235 (45%), Gaps = 26/235 (11%)
Query: 29 AHENKELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHW 88
AH N N L + +N DIVK L+ G P + LH
Sbjct: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKL-----------LLPRGGSPHSPAWNGYTPLHI 608
Query: 89 AAINNRLDLVKFYISKGAVVDQLGGDLNS------TPLHWAIRQGHLPMVILLLQHGADP 142
AA N++++ + + Q GG N+ TPLH A ++GH MV LLL A+
Sbjct: 609 AAKQNQVEVARSLL-------QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 143 TLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFL 202
L + G + +HL H+P+ LI G V+ T G TPL +++H + FL
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH-YGNIKLVKFL 720
Query: 203 LKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMA 257
L+ +N K+ +PLH A G+ + V LL+ G+S + + G TPL +A
Sbjct: 721 LQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 81.3 bits (199), Expect = 3e-15
Identities = 71/267 (26%), Positives = 119/267 (44%), Gaps = 36/267 (13%)
Query: 34 ELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINN 93
EL + L N + A G E +ELV G +V ++ + L+ AA N
Sbjct: 63 ELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 122
Query: 94 RLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVI-------------------- 133
L++VKF + GA + D TPL A++QGH +V
Sbjct: 123 HLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA 181
Query: 134 ---------LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQT 184
+LLQ+ +P ++ GF+ +H+A ++++ + L+++G SVN T NG T
Sbjct: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241
Query: 185 PLMLSAHK--VIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSS 242
PL +++ + VI LL + K + TPLH A G+V + LL+ G+
Sbjct: 242 PLHIASRRGNVI---MVRLLLDRGAQIETKTK-DELTPLHCAARNGHVRISEILLDHGAP 297
Query: 243 LDIQNVKGETPLDMALQNKNQLIIHML 269
+ + G +P+ MA Q + + +L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 79.0 bits (193), Expect = 1e-14
Identities = 62/215 (28%), Positives = 102/215 (47%), Gaps = 5/215 (2%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A +YG + L+E K ++ LH A +N LD+VK + +G +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN- 601
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A +Q + + LLQ+G +G + +HLA H ++A L+SK +
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 176 NMTDVNGQTPLMLSAHKVIGPEPTG-FLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVD 234
N+ + +G TPL L A + G P L+K ++ ++ TPLH A GN+ V
Sbjct: 662 NLGNKSGLTPLHLVAQE--GHVPVADVLIKHGVMVDATTRMGY-TPLHVASHYGNIKLVK 718
Query: 235 KLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
LL+ + ++ + G +PL A Q + I+ +L
Sbjct: 719 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 78.2 bits (191), Expect = 2e-14
Identities = 61/221 (27%), Positives = 101/221 (45%), Gaps = 17/221 (7%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A + G E K L++ V K++ + LH AA ++VK + A + L
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN-LATTA 502
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A R+GH+ V+ LL+ A + +GF+ +H+A + + + L+ +
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 176 NMTDVNGQTPLMLSAH-------KVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAG 228
N NG TPL ++ H K++ P +P+ N TPLH A
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS---PHSPAWN------GYTPLHIAAKQN 613
Query: 229 NVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
V LL+ G S + ++V+G TPL +A Q + ++ +L
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 73.6 bits (179), Expect = 5e-13
Identities = 64/226 (28%), Positives = 102/226 (45%), Gaps = 4/226 (1%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A + G E L+E K+ + LH AA ++ + + + + A + G +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 568
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A+ +L +V LLL G P G++ +H+A + + L+ G S
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 176 NMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDK 235
N V G TPL L+A + E LL + N+ +K TPLH G+V D
Sbjct: 629 NAESVQGVTPLHLAAQEGHA-EMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVADV 686
Query: 236 LLEAGSSLDIQNVKGETPLDMALQNKN-QLIIHMLKTEAKMRANQK 280
L++ G +D G TPL +A N +L+ +L+ +A + A K
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK 732
Score = 67.0 bits (162), Expect = 5e-11
Identities = 53/202 (26%), Positives = 86/202 (42%), Gaps = 3/202 (1%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQG 127
L++ G + + ++ LH A+ L +VK + +GA + TPLH A R G
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAG 448
Query: 128 HLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLM 187
H + LLQ+ A + + +H A H ++ L+ + N+ G TPL
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLH 508
Query: 188 LSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQN 247
++A + G T L + TPLH A G V + LLE + +
Sbjct: 509 IAARE--GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 248 VKGETPLDMALQNKNQLIIHML 269
G TPL +A+ + N I+ +L
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLL 588
Score = 52.8 bits (125), Expect = 1e-06
Identities = 43/158 (27%), Positives = 79/158 (50%), Gaps = 7/158 (4%)
Query: 123 AIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNG 182
A R G+L + L++G D + G + +HLA H+ ++ L+ K + T G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 183 QTPLMLSAHKVIG-PEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGS 241
T L ++A + G E L+ + ++N + TPL+ A ++ V LLE G+
Sbjct: 79 NTALHIAA--LAGQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 242 SLDIQNVKGETPLDMALQNKNQ-LIIHMLK--TEAKMR 276
+ ++ G TPL +ALQ ++ ++ H++ T+ K+R
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 52.0 bits (123), Expect = 2e-06
Identities = 57/243 (23%), Positives = 99/243 (40%), Gaps = 65/243 (26%)
Query: 89 AAINNRLDLVKFYISKGAVVDQLGGD-LNSTPLHWAIRQGHLPMVILLL----------- 136
AA + LD ++ G ++ + LN LH A ++GH+ MV+ LL
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 137 ----------------------QHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQS 174
+GA+ +GF+ +++A H+ ++ +L+ G +
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 175 VNMTDVNGQTPLMLS---------AH--------KVIGP-----------EPTGFLLKFN 206
N+ +G TPL ++ AH KV P LL+ +
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196
Query: 207 PSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLII 266
P+ +V+ K TPLH A N+N LL G+S++ G TPL +A + N +++
Sbjct: 197 PNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
Query: 267 HML 269
+L
Sbjct: 256 RLL 258
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 89.4 bits (220), Expect = 9e-18
Identities = 67/246 (27%), Positives = 115/246 (46%), Gaps = 35/246 (14%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQL---------------- 111
L++ G ++ K +S +H AA + LD V+ + A +D +
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
Query: 112 ----------GGDLNS------TPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHL 155
G NS TPLH A ++ H+ ++ LLL+ GA + G + +H+
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410
Query: 156 AVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKI 215
A H+PI+ L+ +G S N+++V +TPL ++A + E +LL+ +N K
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA-RAGHTEVAKYLLQNKAKVNAKAKD 469
Query: 216 HQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKN-QLIIHMLKTEAK 274
Q TPLH A G+ N V LLE ++ ++ G TPL +A + + + ++ +L+ EA
Sbjct: 470 DQ-TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 275 MRANQK 280
K
Sbjct: 529 QACMTK 534
Score = 87.4 bits (215), Expect = 4e-17
Identities = 78/286 (27%), Positives = 129/286 (45%), Gaps = 44/286 (15%)
Query: 37 NAREALPLIEDSSNCDIVKAT---------QYGIFERCKELVEAGYDVRQPDKENVSLLH 87
+ R A L+++ N D++ T Y + L+ G V + ++ LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 88 WAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDG 147
A+ + +V+ + +GA ++ D TPLH A R GH+ + +LL HGA
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 148 EGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAH-------KVI---GPE 197
G S IH+A H+ + L+ ++ ++ TPL ++AH KV+ G +
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 198 P-----TGF-----------------LLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDK 235
P GF LLK S++ V + TPLH A G++ V
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE-SGLTPLHVASFMGHLPIVKN 422
Query: 236 LLEAGSSLDIQNVKGETPLDMALQ-NKNQLIIHMLKTEAKMRANQK 280
LL+ G+S ++ NVK ETPL MA + ++ ++L+ +AK+ A K
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 468
Score = 83.2 bits (204), Expect = 7e-16
Identities = 71/235 (30%), Positives = 106/235 (45%), Gaps = 26/235 (11%)
Query: 29 AHENKELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHW 88
AH N N L + +N DIVK L+ G P + LH
Sbjct: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKL-----------LLPRGGSPHSPAWNGYTPLHI 608
Query: 89 AAINNRLDLVKFYISKGAVVDQLGGDLNS------TPLHWAIRQGHLPMVILLLQHGADP 142
AA N++++ + + Q GG N+ TPLH A ++GH MV LLL A+
Sbjct: 609 AAKQNQVEVARSLL-------QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 143 TLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFL 202
L + G + +HL H+P+ LI G V+ T G TPL +++H + FL
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH-YGNIKLVKFL 720
Query: 203 LKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMA 257
L+ +N K+ +PLH A G+ + V LL+ G+S + + G TPL +A
Sbjct: 721 LQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 81.3 bits (199), Expect = 3e-15
Identities = 71/267 (26%), Positives = 119/267 (44%), Gaps = 36/267 (13%)
Query: 34 ELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINN 93
EL + L N + A G E +ELV G +V ++ + L+ AA N
Sbjct: 63 ELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 122
Query: 94 RLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVI-------------------- 133
L++VKF + GA + D TPL A++QGH +V
Sbjct: 123 HLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA 181
Query: 134 ---------LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQT 184
+LLQ+ +P ++ GF+ +H+A ++++ + L+++G SVN T NG T
Sbjct: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241
Query: 185 PLMLSAHK--VIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSS 242
PL +++ + VI LL + K + TPLH A G+V + LL+ G+
Sbjct: 242 PLHIASRRGNVI---MVRLLLDRGAQIETKTK-DELTPLHCAARNGHVRISEILLDHGAP 297
Query: 243 LDIQNVKGETPLDMALQNKNQLIIHML 269
+ + G +P+ MA Q + + +L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 79.0 bits (193), Expect = 1e-14
Identities = 62/215 (28%), Positives = 102/215 (47%), Gaps = 5/215 (2%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A +YG + L+E K ++ LH A +N LD+VK + +G +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN- 601
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A +Q + + LLQ+G +G + +HLA H ++A L+SK +
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 176 NMTDVNGQTPLMLSAHKVIGPEPTG-FLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVD 234
N+ + +G TPL L A + G P L+K ++ ++ TPLH A GN+ V
Sbjct: 662 NLGNKSGLTPLHLVAQE--GHVPVADVLIKHGVMVDATTRMGY-TPLHVASHYGNIKLVK 718
Query: 235 KLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
LL+ + ++ + G +PL A Q + I+ +L
Sbjct: 719 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 78.2 bits (191), Expect = 2e-14
Identities = 61/221 (27%), Positives = 101/221 (45%), Gaps = 17/221 (7%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A + G E K L++ V K++ + LH AA ++VK + A + L
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN-LATTA 502
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A R+GH+ V+ LL+ A + +GF+ +H+A + + + L+ +
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 176 NMTDVNGQTPLMLSAH-------KVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAG 228
N NG TPL ++ H K++ P +P+ N TPLH A
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS---PHSPAWN------GYTPLHIAAKQN 613
Query: 229 NVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
V LL+ G S + ++V+G TPL +A Q + ++ +L
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 73.6 bits (179), Expect = 5e-13
Identities = 64/226 (28%), Positives = 102/226 (45%), Gaps = 4/226 (1%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A + G E L+E K+ + LH AA ++ + + + + A + G +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 568
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A+ +L +V LLL G P G++ +H+A + + L+ G S
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 176 NMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDK 235
N V G TPL L+A + E LL + N+ +K TPLH G+V D
Sbjct: 629 NAESVQGVTPLHLAAQEGHA-EMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVADV 686
Query: 236 LLEAGSSLDIQNVKGETPLDMALQNKN-QLIIHMLKTEAKMRANQK 280
L++ G +D G TPL +A N +L+ +L+ +A + A K
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK 732
Score = 67.0 bits (162), Expect = 5e-11
Identities = 53/202 (26%), Positives = 86/202 (42%), Gaps = 3/202 (1%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQG 127
L++ G + + ++ LH A+ L +VK + +GA + TPLH A R G
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAG 448
Query: 128 HLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLM 187
H + LLQ+ A + + +H A H ++ L+ + N+ G TPL
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLH 508
Query: 188 LSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQN 247
++A + G T L + TPLH A G V + LLE + +
Sbjct: 509 IAARE--GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 248 VKGETPLDMALQNKNQLIIHML 269
G TPL +A+ + N I+ +L
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLL 588
Score = 52.8 bits (125), Expect = 1e-06
Identities = 43/158 (27%), Positives = 79/158 (50%), Gaps = 7/158 (4%)
Query: 123 AIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNG 182
A R G+L + L++G D + G + +HLA H+ ++ L+ K + T G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 183 QTPLMLSAHKVIG-PEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGS 241
T L ++A + G E L+ + ++N + TPL+ A ++ V LLE G+
Sbjct: 79 NTALHIAA--LAGQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 242 SLDIQNVKGETPLDMALQNKNQ-LIIHMLK--TEAKMR 276
+ ++ G TPL +ALQ ++ ++ H++ T+ K+R
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 52.0 bits (123), Expect = 2e-06
Identities = 57/243 (23%), Positives = 99/243 (40%), Gaps = 65/243 (26%)
Query: 89 AAINNRLDLVKFYISKGAVVDQLGGD-LNSTPLHWAIRQGHLPMVILLL----------- 136
AA + LD ++ G ++ + LN LH A ++GH+ MV+ LL
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 137 ----------------------QHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQS 174
+GA+ +GF+ +++A H+ ++ +L+ G +
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 175 VNMTDVNGQTPLMLS---------AH--------KVIGP-----------EPTGFLLKFN 206
N+ +G TPL ++ AH KV P LL+ +
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196
Query: 207 PSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLII 266
P+ +V+ K TPLH A N+N LL G+S++ G TPL +A + N +++
Sbjct: 197 PNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
Query: 267 HML 269
+L
Sbjct: 256 RLL 258
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 89.4 bits (220), Expect = 9e-18
Identities = 67/246 (27%), Positives = 115/246 (46%), Gaps = 35/246 (14%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQL---------------- 111
L++ G ++ K +S +H AA + LD V+ + A +D +
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
Query: 112 ----------GGDLNS------TPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHL 155
G NS TPLH A ++ H+ ++ LLL+ GA + G + +H+
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410
Query: 156 AVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKI 215
A H+PI+ L+ +G S N+++V +TPL ++A + E +LL+ +N K
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA-RAGHTEVAKYLLQNKAKVNAKAKD 469
Query: 216 HQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKN-QLIIHMLKTEAK 274
Q TPLH A G+ N V LLE ++ ++ G TPL +A + + + ++ +L+ EA
Sbjct: 470 DQ-TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 275 MRANQK 280
K
Sbjct: 529 QACMTK 534
Score = 87.4 bits (215), Expect = 4e-17
Identities = 78/286 (27%), Positives = 129/286 (45%), Gaps = 44/286 (15%)
Query: 37 NAREALPLIEDSSNCDIVKAT---------QYGIFERCKELVEAGYDVRQPDKENVSLLH 87
+ R A L+++ N D++ T Y + L+ G V + ++ LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 88 WAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDG 147
A+ + +V+ + +GA ++ D TPLH A R GH+ + +LL HGA
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 148 EGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAH-------KVI---GPE 197
G S IH+A H+ + L+ ++ ++ TPL ++AH KV+ G +
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 198 P-----TGF-----------------LLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDK 235
P GF LLK S++ V + TPLH A G++ V
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE-SGLTPLHVASFMGHLPIVKN 422
Query: 236 LLEAGSSLDIQNVKGETPLDMALQ-NKNQLIIHMLKTEAKMRANQK 280
LL+ G+S ++ NVK ETPL MA + ++ ++L+ +AK+ A K
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 468
Score = 83.2 bits (204), Expect = 7e-16
Identities = 71/235 (30%), Positives = 106/235 (45%), Gaps = 26/235 (11%)
Query: 29 AHENKELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHW 88
AH N N L + +N DIVK L+ G P + LH
Sbjct: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKL-----------LLPRGGSPHSPAWNGYTPLHI 608
Query: 89 AAINNRLDLVKFYISKGAVVDQLGGDLNS------TPLHWAIRQGHLPMVILLLQHGADP 142
AA N++++ + + Q GG N+ TPLH A ++GH MV LLL A+
Sbjct: 609 AAKQNQVEVARSLL-------QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 143 TLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFL 202
L + G + +HL H+P+ LI G V+ T G TPL +++H + FL
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH-YGNIKLVKFL 720
Query: 203 LKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMA 257
L+ +N K+ +PLH A G+ + V LL+ G+S + + G TPL +A
Sbjct: 721 LQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 81.3 bits (199), Expect = 3e-15
Identities = 71/267 (26%), Positives = 119/267 (44%), Gaps = 36/267 (13%)
Query: 34 ELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINN 93
EL + L N + A G E +ELV G +V ++ + L+ AA N
Sbjct: 63 ELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 122
Query: 94 RLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVI-------------------- 133
L++VKF + GA + D TPL A++QGH +V
Sbjct: 123 HLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA 181
Query: 134 ---------LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQT 184
+LLQ+ +P ++ GF+ +H+A ++++ + L+++G SVN T NG T
Sbjct: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241
Query: 185 PLMLSAHK--VIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSS 242
PL +++ + VI LL + K + TPLH A G+V + LL+ G+
Sbjct: 242 PLHIASRRGNVI---MVRLLLDRGAQIETKTK-DELTPLHCAARNGHVRISEILLDHGAP 297
Query: 243 LDIQNVKGETPLDMALQNKNQLIIHML 269
+ + G +P+ MA Q + + +L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 79.0 bits (193), Expect = 1e-14
Identities = 62/215 (28%), Positives = 102/215 (47%), Gaps = 5/215 (2%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A +YG + L+E K ++ LH A +N LD+VK + +G +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN- 601
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A +Q + + LLQ+G +G + +HLA H ++A L+SK +
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 176 NMTDVNGQTPLMLSAHKVIGPEPTG-FLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVD 234
N+ + +G TPL L A + G P L+K ++ ++ TPLH A GN+ V
Sbjct: 662 NLGNKSGLTPLHLVAQE--GHVPVADVLIKHGVMVDATTRMGY-TPLHVASHYGNIKLVK 718
Query: 235 KLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
LL+ + ++ + G +PL A Q + I+ +L
Sbjct: 719 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 78.2 bits (191), Expect = 2e-14
Identities = 61/221 (27%), Positives = 101/221 (45%), Gaps = 17/221 (7%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A + G E K L++ V K++ + LH AA ++VK + A + L
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN-LATTA 502
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A R+GH+ V+ LL+ A + +GF+ +H+A + + + L+ +
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 176 NMTDVNGQTPLMLSAH-------KVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAG 228
N NG TPL ++ H K++ P +P+ N TPLH A
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS---PHSPAWN------GYTPLHIAAKQN 613
Query: 229 NVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
V LL+ G S + ++V+G TPL +A Q + ++ +L
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 73.6 bits (179), Expect = 5e-13
Identities = 64/226 (28%), Positives = 102/226 (45%), Gaps = 4/226 (1%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A + G E L+E K+ + LH AA ++ + + + + A + G +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 568
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A+ +L +V LLL G P G++ +H+A + + L+ G S
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 176 NMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDK 235
N V G TPL L+A + E LL + N+ +K TPLH G+V D
Sbjct: 629 NAESVQGVTPLHLAAQEGHA-EMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVADV 686
Query: 236 LLEAGSSLDIQNVKGETPLDMALQNKN-QLIIHMLKTEAKMRANQK 280
L++ G +D G TPL +A N +L+ +L+ +A + A K
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK 732
Score = 67.0 bits (162), Expect = 5e-11
Identities = 53/202 (26%), Positives = 86/202 (42%), Gaps = 3/202 (1%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQG 127
L++ G + + ++ LH A+ L +VK + +GA + TPLH A R G
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAG 448
Query: 128 HLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLM 187
H + LLQ+ A + + +H A H ++ L+ + N+ G TPL
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLH 508
Query: 188 LSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQN 247
++A + G T L + TPLH A G V + LLE + +
Sbjct: 509 IAARE--GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 248 VKGETPLDMALQNKNQLIIHML 269
G TPL +A+ + N I+ +L
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLL 588
Score = 52.8 bits (125), Expect = 1e-06
Identities = 43/158 (27%), Positives = 79/158 (50%), Gaps = 7/158 (4%)
Query: 123 AIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNG 182
A R G+L + L++G D + G + +HLA H+ ++ L+ K + T G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 183 QTPLMLSAHKVIG-PEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGS 241
T L ++A + G E L+ + ++N + TPL+ A ++ V LLE G+
Sbjct: 79 NTALHIAA--LAGQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 242 SLDIQNVKGETPLDMALQNKNQ-LIIHMLK--TEAKMR 276
+ ++ G TPL +ALQ ++ ++ H++ T+ K+R
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 52.0 bits (123), Expect = 2e-06
Identities = 57/243 (23%), Positives = 99/243 (40%), Gaps = 65/243 (26%)
Query: 89 AAINNRLDLVKFYISKGAVVDQLGGD-LNSTPLHWAIRQGHLPMVILLL----------- 136
AA + LD ++ G ++ + LN LH A ++GH+ MV+ LL
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 137 ----------------------QHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQS 174
+GA+ +GF+ +++A H+ ++ +L+ G +
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 175 VNMTDVNGQTPLMLS---------AH--------KVIGP-----------EPTGFLLKFN 206
N+ +G TPL ++ AH KV P LL+ +
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196
Query: 207 PSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLII 266
P+ +V+ K TPLH A N+N LL G+S++ G TPL +A + N +++
Sbjct: 197 PNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
Query: 267 HML 269
+L
Sbjct: 256 RLL 258
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 89.4 bits (220), Expect = 9e-18
Identities = 67/246 (27%), Positives = 115/246 (46%), Gaps = 35/246 (14%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQL---------------- 111
L++ G ++ K +S +H AA + LD V+ + A +D +
Sbjct: 291 LLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGH 350
Query: 112 ----------GGDLNS------TPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHL 155
G NS TPLH A ++ H+ ++ LLL+ GA + G + +H+
Sbjct: 351 HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHV 410
Query: 156 AVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKI 215
A H+PI+ L+ +G S N+++V +TPL ++A + E +LL+ +N K
Sbjct: 411 ASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAA-RAGHTEVAKYLLQNKAKVNAKAKD 469
Query: 216 HQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKN-QLIIHMLKTEAK 274
Q TPLH A G+ N V LLE ++ ++ G TPL +A + + + ++ +L+ EA
Sbjct: 470 DQ-TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEAS 528
Query: 275 MRANQK 280
K
Sbjct: 529 QACMTK 534
Score = 87.4 bits (215), Expect = 4e-17
Identities = 78/286 (27%), Positives = 129/286 (45%), Gaps = 44/286 (15%)
Query: 37 NAREALPLIEDSSNCDIVKAT---------QYGIFERCKELVEAGYDVRQPDKENVSLLH 87
+ R A L+++ N D++ T Y + L+ G V + ++ LH
Sbjct: 185 DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLH 244
Query: 88 WAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDG 147
A+ + +V+ + +GA ++ D TPLH A R GH+ + +LL HGA
Sbjct: 245 IASRRGNVIMVRLLLDRGAQIETKTKD-ELTPLHCAARNGHVRISEILLDHGAPIQAKTK 303
Query: 148 EGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAH-------KVI---GPE 197
G S IH+A H+ + L+ ++ ++ TPL ++AH KV+ G +
Sbjct: 304 NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAK 363
Query: 198 P-----TGF-----------------LLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDK 235
P GF LLK S++ V + TPLH A G++ V
Sbjct: 364 PNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTE-SGLTPLHVASFMGHLPIVKN 422
Query: 236 LLEAGSSLDIQNVKGETPLDMALQ-NKNQLIIHMLKTEAKMRANQK 280
LL+ G+S ++ NVK ETPL MA + ++ ++L+ +AK+ A K
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAK 468
Score = 83.2 bits (204), Expect = 7e-16
Identities = 71/235 (30%), Positives = 106/235 (45%), Gaps = 26/235 (11%)
Query: 29 AHENKELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHW 88
AH N N L + +N DIVK L+ G P + LH
Sbjct: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKL-----------LLPRGGSPHSPAWNGYTPLHI 608
Query: 89 AAINNRLDLVKFYISKGAVVDQLGGDLNS------TPLHWAIRQGHLPMVILLLQHGADP 142
AA N++++ + + Q GG N+ TPLH A ++GH MV LLL A+
Sbjct: 609 AAKQNQVEVARSLL-------QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 143 TLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFL 202
L + G + +HL H+P+ LI G V+ T G TPL +++H + FL
Sbjct: 662 NLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASH-YGNIKLVKFL 720
Query: 203 LKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMA 257
L+ +N K+ +PLH A G+ + V LL+ G+S + + G TPL +A
Sbjct: 721 LQHQADVNAKTKLGY-SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774
Score = 81.3 bits (199), Expect = 3e-15
Identities = 71/267 (26%), Positives = 119/267 (44%), Gaps = 36/267 (13%)
Query: 34 ELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINN 93
EL + L N + A G E +ELV G +V ++ + L+ AA N
Sbjct: 63 ELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQEN 122
Query: 94 RLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVI-------------------- 133
L++VKF + GA + D TPL A++QGH +V
Sbjct: 123 HLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAA 181
Query: 134 ---------LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQT 184
+LLQ+ +P ++ GF+ +H+A ++++ + L+++G SVN T NG T
Sbjct: 182 RNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGIT 241
Query: 185 PLMLSAHK--VIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSS 242
PL +++ + VI LL + K + TPLH A G+V + LL+ G+
Sbjct: 242 PLHIASRRGNVI---MVRLLLDRGAQIETKTK-DELTPLHCAARNGHVRISEILLDHGAP 297
Query: 243 LDIQNVKGETPLDMALQNKNQLIIHML 269
+ + G +P+ MA Q + + +L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Score = 79.0 bits (193), Expect = 1e-14
Identities = 62/215 (28%), Positives = 102/215 (47%), Gaps = 5/215 (2%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A +YG + L+E K ++ LH A +N LD+VK + +G +
Sbjct: 543 AAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWN- 601
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A +Q + + LLQ+G +G + +HLA H ++A L+SK +
Sbjct: 602 GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661
Query: 176 NMTDVNGQTPLMLSAHKVIGPEPTG-FLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVD 234
N+ + +G TPL L A + G P L+K ++ ++ TPLH A GN+ V
Sbjct: 662 NLGNKSGLTPLHLVAQE--GHVPVADVLIKHGVMVDATTRMGY-TPLHVASHYGNIKLVK 718
Query: 235 KLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
LL+ + ++ + G +PL A Q + I+ +L
Sbjct: 719 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLL 753
Score = 78.2 bits (191), Expect = 2e-14
Identities = 61/221 (27%), Positives = 101/221 (45%), Gaps = 17/221 (7%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A + G E K L++ V K++ + LH AA ++VK + A + L
Sbjct: 444 AARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPN-LATTA 502
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A R+GH+ V+ LL+ A + +GF+ +H+A + + + L+ +
Sbjct: 503 GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHP 562
Query: 176 NMTDVNGQTPLMLSAH-------KVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAG 228
N NG TPL ++ H K++ P +P+ N TPLH A
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS---PHSPAWN------GYTPLHIAAKQN 613
Query: 229 NVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
V LL+ G S + ++V+G TPL +A Q + ++ +L
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Score = 73.6 bits (179), Expect = 5e-13
Identities = 64/226 (28%), Positives = 102/226 (45%), Gaps = 4/226 (1%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A + G E L+E K+ + LH AA ++ + + + + A + G +
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKN- 568
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A+ +L +V LLL G P G++ +H+A + + L+ G S
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 628
Query: 176 NMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDK 235
N V G TPL L+A + E LL + N+ +K TPLH G+V D
Sbjct: 629 NAESVQGVTPLHLAAQEGHA-EMVALLLSKQANGNLGNKSGL-TPLHLVAQEGHVPVADV 686
Query: 236 LLEAGSSLDIQNVKGETPLDMALQNKN-QLIIHMLKTEAKMRANQK 280
L++ G +D G TPL +A N +L+ +L+ +A + A K
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTK 732
Score = 67.0 bits (162), Expect = 5e-11
Identities = 53/202 (26%), Positives = 86/202 (42%), Gaps = 3/202 (1%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQG 127
L++ G + + ++ LH A+ L +VK + +GA + TPLH A R G
Sbjct: 390 LLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA-SPNVSNVKVETPLHMAARAG 448
Query: 128 HLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLM 187
H + LLQ+ A + + +H A H ++ L+ + N+ G TPL
Sbjct: 449 HTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLH 508
Query: 188 LSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQN 247
++A + G T L + TPLH A G V + LLE + +
Sbjct: 509 IAARE--GHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAG 566
Query: 248 VKGETPLDMALQNKNQLIIHML 269
G TPL +A+ + N I+ +L
Sbjct: 567 KNGLTPLHVAVHHNNLDIVKLL 588
Score = 52.8 bits (125), Expect = 1e-06
Identities = 43/158 (27%), Positives = 79/158 (50%), Gaps = 7/158 (4%)
Query: 123 AIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNG 182
A R G+L + L++G D + G + +HLA H+ ++ L+ K + T G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 183 QTPLMLSAHKVIG-PEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGS 241
T L ++A + G E L+ + ++N + TPL+ A ++ V LLE G+
Sbjct: 79 NTALHIAA--LAGQDEVVRELVNYGANVNAQSQ-KGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 242 SLDIQNVKGETPLDMALQNKNQ-LIIHMLK--TEAKMR 276
+ ++ G TPL +ALQ ++ ++ H++ T+ K+R
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 52.0 bits (123), Expect = 2e-06
Identities = 57/243 (23%), Positives = 99/243 (40%), Gaps = 65/243 (26%)
Query: 89 AAINNRLDLVKFYISKGAVVDQLGGD-LNSTPLHWAIRQGHLPMVILLL----------- 136
AA + LD ++ G ++ + LN LH A ++GH+ MV+ LL
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNG--LHLASKEGHVKMVVELLHKEIILETTTK 76
Query: 137 ----------------------QHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQS 174
+GA+ +GF+ +++A H+ ++ +L+ G +
Sbjct: 77 KGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGAN 136
Query: 175 VNMTDVNGQTPLMLS---------AH--------KVIGP-----------EPTGFLLKFN 206
N+ +G TPL ++ AH KV P LL+ +
Sbjct: 137 QNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQND 196
Query: 207 PSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLII 266
P+ +V+ K TPLH A N+N LL G+S++ G TPL +A + N +++
Sbjct: 197 PNPDVLSKT-GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMV 255
Query: 267 HML 269
+L
Sbjct: 256 RLL 258
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 87.0 bits (214), Expect = 5e-17
Identities = 69/249 (27%), Positives = 113/249 (45%), Gaps = 8/249 (3%)
Query: 29 AHENKELANAREALPLIEDSSNCDIVKATQY------GIFERCKELVEAGYDVRQPDKEN 82
A NK + A +PL+ + + D T G E K L+ G ++ DK++
Sbjct: 114 AAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKD 173
Query: 83 VSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADP 142
+HWAA +++VK +S GA V + TPLH A G + +V LL G D
Sbjct: 174 RRAIHWAAYMGHIEVVKLLVSHGAEVT-CKDKKSYTPLHAAASSGMISVVKYLLDLGVDM 232
Query: 143 TLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFL 202
+ G + +H+A ++ LI G VN + G TPL +A G L
Sbjct: 233 NEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELL 292
Query: 203 LKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKN 262
+ +N+ K TPLH G + ++++G+ +D ++ G TPL +A + +
Sbjct: 293 VGNGADVNMKSK-DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGH 351
Query: 263 QLIIHMLKT 271
+L+I+ L T
Sbjct: 352 ELLINTLIT 360
Score = 75.5 bits (184), Expect = 1e-13
Identities = 65/228 (28%), Positives = 102/228 (44%), Gaps = 5/228 (2%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A G+ K L++ G D+ +P+ + LH A N + +V I GA+V+Q +
Sbjct: 213 AASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKN-EK 271
Query: 116 NSTPLHWAIRQGHLPMVI-LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQS 174
TPLH+A H + + LL+ +GAD + +G + +H+ L +I G
Sbjct: 272 GFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAV 331
Query: 175 VNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVD 234
++ D NG TPL ++A G E L + + IH PLH A +G +
Sbjct: 332 IDCEDKNGNTPLHIAAR--YGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCR 389
Query: 235 KLLEAGSSLDIQNVKGETPLDMALQNKN-QLIIHMLKTEAKMRANQKF 281
KLL +G +D + G T L A N + + +L T A KF
Sbjct: 390 KLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKF 437
Score = 67.8 bits (164), Expect = 3e-11
Identities = 52/209 (24%), Positives = 97/209 (46%), Gaps = 12/209 (5%)
Query: 60 GIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTP 119
G + C++L+ +G+D+ PD + LH AA L+ + ++ GA ++ +P
Sbjct: 383 GFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKD-KFGRSP 441
Query: 120 LHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQ-HMPIIAYLISKGQSVNMT 178
LH+A + + L+ GA +D G + +H A + YL+ + +
Sbjct: 442 LHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIR 501
Query: 179 DVNGQTPLMLSA---HK-----VIGPEPTGFLLKFNPSLNVVDKIHQNT--PLHWAVAAG 228
D G + SA H+ + P L++ + + + D ++ T PLH A G
Sbjct: 502 DKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHG 561
Query: 229 NVNAVDKLLEAGSSLDIQNVKGETPLDMA 257
+ A++ L+++ LD++N G TPLD+A
Sbjct: 562 HHQALEVLVQSLLDLDVRNSSGRTPLDLA 590
Score = 67.0 bits (162), Expect = 5e-11
Identities = 55/197 (27%), Positives = 90/197 (45%), Gaps = 4/197 (2%)
Query: 67 ELVEAGYDVRQPDKENVSLLHWAAINNRLDL-VKFYISKGAVVDQLGGDLNSTPLHWAIR 125
EL++ G V Q +++ + LH+AA + L ++ + GA V+ D TPLH
Sbjct: 257 ELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKD-GKTPLHMTAL 315
Query: 126 QGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTP 185
G ++Q GA D G + +H+A + H +I LI+ G ++G P
Sbjct: 316 HGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFP 375
Query: 186 LMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDI 245
L L+A + LL ++ D + T LH A A GN+ ++ LL G+ +
Sbjct: 376 LHLAALSGFS-DCCRKLLSSGFDIDTPDDFGR-TCLHAAAAGGNLECLNLLLNTGADFNK 433
Query: 246 QNVKGETPLDMALQNKN 262
++ G +PL A N N
Sbjct: 434 KDKFGRSPLHYAAANCN 450
Score = 65.9 bits (159), Expect = 1e-10
Identities = 65/249 (26%), Positives = 104/249 (41%), Gaps = 34/249 (13%)
Query: 53 IVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLG 112
+V+A G + + L+ DV D E + LH AA ++++ I GA V+
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD 71
Query: 113 GDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKG 172
TPLH A+ V +LL+H AD D + +H+A + + L+
Sbjct: 72 SKW-LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
Query: 173 QSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDK-----IH----------- 216
+VN++D G+T L +A G E LL ++N DK IH
Sbjct: 131 SNVNVSDRAGRTALHHAAFSGHG-EMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVV 189
Query: 217 ----------------QNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQN 260
TPLH A ++G ++ V LL+ G ++ N G TPL +A N
Sbjct: 190 KLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYN 249
Query: 261 KNQLIIHML 269
++++ L
Sbjct: 250 GQDVVVNEL 258
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/199 (27%), Positives = 91/199 (45%), Gaps = 14/199 (7%)
Query: 79 DKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAI---RQGHLPMVILL 135
D + LHWA N V+ + + V + G+ S PLH A+ +G M+I
Sbjct: 753 DNHGYTALHWACYNGHETCVELLLEQ-EVFQKTEGNAFS-PLHCAVINDNEGAAEMLIDT 810
Query: 136 LQHGAD-PTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVI 194
L GA D +G + +H A H+ + L+S VN D G+TPLM++A
Sbjct: 811 L--GASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAEN-- 866
Query: 195 GPEPTGFLLKFNPSLNV-VDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKG--- 250
G T +L + S + + +NT LH A + G+ + +LE + ++ N
Sbjct: 867 GQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAAL 926
Query: 251 ETPLDMALQNKNQLIIHML 269
+TPL +A +N +++ L
Sbjct: 927 QTPLHVAARNGLTMVVQEL 945
Score = 58.2 bits (139), Expect = 2e-08
Identities = 56/244 (22%), Positives = 103/244 (42%), Gaps = 10/244 (4%)
Query: 36 ANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRL 95
A + A+ + + + ++ + G + L+ G +V DK + LH A+
Sbjct: 640 AEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHE 699
Query: 96 DLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGA----DPTLIDGEGFS 151
+ V + GA L TP+H + GH+ ++ LLQ A +P D G++
Sbjct: 700 ECVDALLQHGAKC-LLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYT 758
Query: 152 SIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNV 211
++H A H + L+ + + T+ N +PL + + E +L ++
Sbjct: 759 ALHWACYNGHETCVELLLEQ-EVFQKTEGNAFSPLHCAV--INDNEGAAEMLIDTLGASI 815
Query: 212 VDKIHQN--TPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
V+ TPLH A +V + LL + ++ + G+TPL MA +N + ML
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Query: 270 KTEA 273
+ A
Sbjct: 876 VSSA 879
Score = 55.8 bits (133), Expect = 1e-07
Identities = 60/232 (25%), Positives = 95/232 (40%), Gaps = 7/232 (3%)
Query: 36 ANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRL 95
A + +A P D+ + Y E C EL+ ++ + S LH A IN+
Sbjct: 742 AASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNE 801
Query: 96 DLVKFYISK-GAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIH 154
+ I GA + TPLH A H+ + LLL H A +D G + +
Sbjct: 802 GAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLM 861
Query: 155 LAVLFQHMPIIAYLISKGQS-VNMTDVNGQTPLMLSAHKVIGPEPTGFL-LKFNPSLNVV 212
+A + L+S + + + D + T L L+ K G E + L L+ N++
Sbjct: 862 MAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK--GHETSALLILEKITDRNLI 919
Query: 213 DKIHQ--NTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKN 262
+ + TPLH A G V +LL G+S+ + G TP NK+
Sbjct: 920 NATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKD 971
Score = 55.5 bits (132), Expect = 1e-07
Identities = 57/193 (29%), Positives = 83/193 (43%), Gaps = 15/193 (7%)
Query: 86 LHWAAINNRLDLVKFYISKGA---VVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADP 142
+H AA N + ++ I VD G+ TPL ++ GH V LL GA+
Sbjct: 621 IHAAATNGHSECLRLLIGNAEPQNAVDIQDGN-GQTPLMLSVLNGHTDCVYSLLNKGANV 679
Query: 143 TLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAH-KVIGPEPTGF 201
D G +++H + H + L+ G + D G+TP+ LSA IG G
Sbjct: 680 DAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIG--VLGA 737
Query: 202 LLKFNPSLN---VVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGE--TPLDM 256
LL+ S++ H T LHWA G+ V+ LLE Q +G +PL
Sbjct: 738 LLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV---FQKTEGNAFSPLHC 794
Query: 257 ALQNKNQLIIHML 269
A+ N N+ ML
Sbjct: 795 AVINDNEGAAEML 807
Score = 50.1 bits (118), Expect = 6e-06
Identities = 60/250 (24%), Positives = 99/250 (39%), Gaps = 53/250 (21%)
Query: 79 DKENVSLLHWAAINNR---LDLVKFYISKGAVVDQLGGDLNS--------TPLHWAIRQG 127
DK+ + +H++A L L+ +++ G D+ S +PLH A G
Sbjct: 502 DKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHG 561
Query: 128 HLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQS------------- 174
H + +L+Q D + + G + + LA H+ + LI++G S
Sbjct: 562 HHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPI 621
Query: 175 ------------------------VNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLN 210
V++ D NGQTPLMLS V+ N N
Sbjct: 622 HAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS---VLNGHTDCVYSLLNKGAN 678
Query: 211 VVDKIH-QNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDM-ALQNKNQLIIHM 268
V K T LH G+ VD LL+ G+ +++ +G TP+ + A ++ +
Sbjct: 679 VDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGAL 738
Query: 269 LKTEAKMRAN 278
L++ A M AN
Sbjct: 739 LQSAASMDAN 748
Score = 46.2 bits (108), Expect = 9e-05
Identities = 47/162 (29%), Positives = 66/162 (40%), Gaps = 9/162 (5%)
Query: 123 AIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNG 182
AI G V L+ D D E + +H A II LI G VN D
Sbjct: 15 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
Query: 183 QTPLMLSAHKVI---GPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEA 239
TPL H+ + E LLK + +N DK Q TPLH A A V + L+
Sbjct: 75 LTPL----HRAVASCSEEAVQVLLKHSADVNARDKNWQ-TPLHIAAANKAVKCAEALVPL 129
Query: 240 GSSLDIQNVKGETPL-DMALQNKNQLIIHMLKTEAKMRANQK 280
S++++ + G T L A +++ +L A + A K
Sbjct: 130 LSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDK 171
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 85.9 bits (211), Expect = 1e-16
Identities = 65/206 (31%), Positives = 103/206 (50%), Gaps = 4/206 (1%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A + G + C LV+AG ++ ++ + L AA NN L+ VK+ I GA+VD +
Sbjct: 780 AAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAE- 838
Query: 116 NSTPLHWAIRQGHLPMVILLLQHG-ADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQS 174
ST LH A ++GH +V LL +G D D G++ + A ++H+ ++ L+SKG
Sbjct: 839 GSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSD 898
Query: 175 VNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVD 234
+N+ D L +A + LL L+ V+ IH ++PLH A + V
Sbjct: 899 INIRDNEENICLHWAAFSGC-VDIAEILLAAKCDLHAVN-IHGDSPLHIAARENRYDCVV 956
Query: 235 KLLEAGSSLDIQNVKGETPLDMALQN 260
L S + ++N +GETPL A N
Sbjct: 957 LFLSRDSDVTLKNKEGETPLQCASLN 982
Score = 64.3 bits (155), Expect = 3e-10
Identities = 55/200 (27%), Positives = 85/200 (42%), Gaps = 41/200 (20%)
Query: 118 TPLHWAIRQGHLPMVILLLQHGA-----------------------------------DP 142
+PLH A GH+ + +L+Q GA DP
Sbjct: 775 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 834
Query: 143 TLIDGEGFSSIHLAVLFQHMPIIAYLISKGQ-SVNMTDVNGQTPLMLSAHKVIGPEPTGF 201
D EG + +HLA H ++ YL+S GQ VN D G TP M+ A + +
Sbjct: 835 K--DAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTP-MIWATEYKHVDLVKL 891
Query: 202 LLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMAL-QN 260
LL +N+ D +N LHWA +G V+ + LL A L N+ G++PL +A +N
Sbjct: 892 LLSKGSDINIRDN-EENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAAREN 950
Query: 261 KNQLIIHMLKTEAKMRANQK 280
+ ++ L ++ + K
Sbjct: 951 RYDCVVLFLSRDSDVTLKNK 970
Score = 50.1 bits (118), Expect = 6e-06
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 8/173 (4%)
Query: 120 LHWAIRQGHLPMVILLLQHGADPT--LIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNM 177
L+++ RQG L V+L+L G DP + S +H A H+ I L+ G +++
Sbjct: 742 LYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDT 801
Query: 178 TDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLL 237
+ +TPLM +A E +L+K ++ D +T LH A G+ V LL
Sbjct: 802 CSEDQRTPLMEAAEN-NHLEAVKYLIKAGALVDPKD-AEGSTCLHLAAKKGHYEVVQYLL 859
Query: 238 EAGS-SLDIQNVKGETPLDMALQNKNQLIIHML---KTEAKMRANQKFRLWRW 286
G ++ Q+ G TP+ A + K+ ++ +L ++ +R N++ W
Sbjct: 860 SNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHW 912
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 85.1 bits (209), Expect = 2e-16
Identities = 66/214 (30%), Positives = 103/214 (48%), Gaps = 4/214 (1%)
Query: 65 CKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAI 124
C L+ G D + D++ + LH+AA N + + GA VD + TPLH A
Sbjct: 411 CALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE-GWTPLHLAA 469
Query: 125 RQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQT 184
+ + LL+ ADP L + EG + +H+A F H+ ++ L S+G ++ N +T
Sbjct: 470 QNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRT 529
Query: 185 PLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLD 244
PL L+ + LLK + +D+ PLH A A G LL G+SL+
Sbjct: 530 PLHLAVERG-KVRAIQHLLKSGAVPDALDQSGYG-PLHTAAARGKYLICKMLLRYGASLE 587
Query: 245 IQNVKGETPLDMALQNKNQLIIHML-KTEAKMRA 277
+ +G TPL +A + IIH+L ++ A M A
Sbjct: 588 LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGA 621
Score = 79.0 bits (193), Expect = 1e-14
Identities = 59/215 (27%), Positives = 105/215 (48%), Gaps = 3/215 (1%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A + G + L+++G D+ LH AA + + K + GA ++ L
Sbjct: 534 AVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLE-LPTHQ 592
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A +GHL ++ LL + A+ + ++ +HLA +++ L+ G
Sbjct: 593 GWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADP 652
Query: 176 NMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDK 235
N + +G TPL L+ + LL+ + +++ +K+ TP H A GN +
Sbjct: 653 NAAEQSGWTPLHLAVQRSTFLSVIN-LLEHHANVHARNKVGW-TPAHLAALKGNTAILKV 710
Query: 236 LLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLK 270
L+EAG+ LD+Q+ TPL +AL+++ Q I+ L+
Sbjct: 711 LVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLE 745
Score = 60.8 bits (146), Expect = 4e-09
Identities = 53/190 (27%), Positives = 78/190 (41%), Gaps = 36/190 (18%)
Query: 118 TPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNM 177
TPLH+ + QG + V LLL H D G++ + +A Q + A L++ G N
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 178 TDVNGQTPLMLSAHKVIGPEPTGFLL------------------------------KFNP 207
D +G PL +A G + T LL +
Sbjct: 424 VDEDGWAPLHFAAQN--GDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
Query: 208 SLNVVDKIHQ---NTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQ-NKNQ 263
S +H+ TPLH A G+V+ V L G+ LD Q TPL +A++ K +
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVR 541
Query: 264 LIIHMLKTEA 273
I H+LK+ A
Sbjct: 542 AIQHLLKSGA 551
>gi|90186267 ankyrin repeat domain 55 isoform 1 [Homo sapiens]
Length = 614
Score = 84.7 bits (208), Expect = 2e-16
Identities = 63/223 (28%), Positives = 101/223 (45%), Gaps = 5/223 (2%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
AT G E C L+ G PDK LH A + L+ + + + + D
Sbjct: 101 ATYLGWLEGCVSLLRNGAKHNIPDKNGRLPLHAATAEPDMRLLTVLLQQSNISEINHQDN 160
Query: 116 NS-TPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQS 174
TPLHWA +LL+ GADPTL+D + +++H AV + + + ++S Q
Sbjct: 161 EGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTALHWAVQSGNRILCSIILSHHQG 220
Query: 175 ---VNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVN 231
+N D +G+T + ++A +L +D + TPLHWA AAG
Sbjct: 221 PSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALD-VDDRTPLHWAAAAGKAE 279
Query: 232 AVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAK 274
V LLE G +++++ TPL AL + + +L E++
Sbjct: 280 CVQSLLELGMDSNLRDINESTPLAYALYCGHTACVKLLSQESR 322
Score = 55.1 bits (131), Expect = 2e-07
Identities = 46/195 (23%), Positives = 85/195 (43%), Gaps = 8/195 (4%)
Query: 79 DKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQH 138
++ ++++++ AA N ++ + I + + + TPL A+ V LLL+
Sbjct: 24 EEVDLTMVYQAASNGDVNALTAVIREDPSILECCDSEGCTPLMHAVSGRQADTVKLLLKM 83
Query: 139 GADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEP 198
GA+ + D G +S+ LA + L+ G N+ D NG+ PL H
Sbjct: 84 GANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGAKHNIPDKNGRLPL----HAATAEPD 139
Query: 199 TGFLLKFNPSLNVVDKIHQN----TPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPL 254
L N+ + HQ+ TPLHWA LL+ G+ + + +T L
Sbjct: 140 MRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTAL 199
Query: 255 DMALQNKNQLIIHML 269
A+Q+ N+++ ++
Sbjct: 200 HWAVQSGNRILCSII 214
>gi|37594451 Abl-philin 2 isoform 2 [Homo sapiens]
Length = 361
Score = 84.0 bits (206), Expect = 4e-16
Identities = 55/214 (25%), Positives = 101/214 (47%), Gaps = 25/214 (11%)
Query: 376 FYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFRTFCTSCLIRK 435
F++S ++++ ++ +Y+ T PG+ + I T++ C C+ K
Sbjct: 119 FFYSH-WNLILIVFHYYQAITTPPGYPPQGRND----IATVS---------ICKKCIYPK 164
Query: 436 PLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSF-IYLS 494
P R+ HC +CN CV + D HC W C+G NH Y+ F FF+++ C + YGS+ ++
Sbjct: 165 PARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSYGSWDLFRE 224
Query: 495 SHCA-TTFKEDGLWTYLNQIVACSPWVLYILMLATFHFSWSTFLLLNQL----FQIAFLG 549
++ A T+ + T+ + ++Y+ L + S L L L + G
Sbjct: 225 AYAAIETYHQTPPPTFSFRERMTHKSLVYLWFLCS-----SVALALGALTVWHAVLISRG 279
Query: 550 LTSHERISLQKQSKHMKQTLSLRKTPYNLGFMQN 583
TS ER +K+ + ++ + + PYN G + N
Sbjct: 280 ETSIERHINKKERRRLQAKGRVFRNPYNYGCLDN 313
>gi|37594449 Abl-philin 2 isoform 1 [Homo sapiens]
Length = 377
Score = 82.8 bits (203), Expect = 9e-16
Identities = 56/225 (24%), Positives = 97/225 (43%), Gaps = 31/225 (13%)
Query: 376 FYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFRTFCTSCLIRK 435
F++S ++++ ++ +Y+ T PG+ + I T++ C C+ K
Sbjct: 119 FFYSH-WNLILIVFHYYQAITTPPGYPPQGRND----IATVS---------ICKKCIYPK 164
Query: 436 PLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSF----- 490
P R+ HC +CN CV + D HC W C+G NH Y+ F FF+++ C + YGS+
Sbjct: 165 PARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSYGSWDLFRE 224
Query: 491 IYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFS--WSTFLLLNQLFQIAFL 548
Y + ++ L NQ +P + H S + FL + + L
Sbjct: 225 AYAAIEKMKQLDKNKLQAVANQTYHQTPPPTFSFRERMTHKSLVYLWFLCSSVALALGAL 284
Query: 549 ----------GLTSHERISLQKQSKHMKQTLSLRKTPYNLGFMQN 583
G TS ER +K+ + ++ + + PYN G + N
Sbjct: 285 TVWHAVLISRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDN 329
>gi|37594455 Abl-philin 2 isoform 1 [Homo sapiens]
Length = 377
Score = 82.8 bits (203), Expect = 9e-16
Identities = 56/225 (24%), Positives = 97/225 (43%), Gaps = 31/225 (13%)
Query: 376 FYFSFIFSIVAFLYFFYKTWATDPGFTKASEEEKKVNIITLAETGSLDFRTFCTSCLIRK 435
F++S ++++ ++ +Y+ T PG+ + I T++ C C+ K
Sbjct: 119 FFYSH-WNLILIVFHYYQAITTPPGYPPQGRND----IATVS---------ICKKCIYPK 164
Query: 436 PLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHHYYIFFLFFLSMVCGWIIYGSF----- 490
P R+ HC +CN CV + D HC W C+G NH Y+ F FF+++ C + YGS+
Sbjct: 165 PARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHRYFFSFCFFMTLGCVYCSYGSWDLFRE 224
Query: 491 IYLSSHCATTFKEDGLWTYLNQIVACSPWVLYILMLATFHFS--WSTFLLLNQLFQIAFL 548
Y + ++ L NQ +P + H S + FL + + L
Sbjct: 225 AYAAIEKMKQLDKNKLQAVANQTYHQTPPPTFSFRERMTHKSLVYLWFLCSSVALALGAL 284
Query: 549 ----------GLTSHERISLQKQSKHMKQTLSLRKTPYNLGFMQN 583
G TS ER +K+ + ++ + + PYN G + N
Sbjct: 285 TVWHAVLISRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDN 329
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 82.4 bits (202), Expect = 1e-15
Identities = 66/240 (27%), Positives = 109/240 (45%), Gaps = 8/240 (3%)
Query: 35 LANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNR 94
LA +L + + S + A G E L+ G + DK+ LHWAA
Sbjct: 126 LAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGH 185
Query: 95 LDLVKFYISKGAVV---DQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFS 151
L+++K +++GA + D+ G L LH A G + +V LL+ GA+ + G +
Sbjct: 186 LEVLKLLVARGADLGCKDRKGYGL----LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNT 241
Query: 152 SIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNV 211
++H+A + L++ G +VN + G TPL ++A G L+ +N
Sbjct: 242 ALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNY 301
Query: 212 VDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKT 271
K +PLH A G L++ GS +D + G TPL +A + ++L+I L T
Sbjct: 302 QSK-EGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMT 360
Score = 77.0 bits (188), Expect = 5e-14
Identities = 58/193 (30%), Positives = 83/193 (43%), Gaps = 18/193 (9%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQG 127
LV G DV KE S LH AAI+ R + I G+ +D +TPLH A R G
Sbjct: 292 LVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEID-CADKFGNTPLHVAARYG 350
Query: 128 HLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLM 187
H ++ L+ +GAD +HLAVLF L+S GQ ++ ++
Sbjct: 351 HELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVL 410
Query: 188 LSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQN 247
+ + P+ G T LH A + GNV ++ LL +G+ L ++
Sbjct: 411 SAGFDINTPDNLG-----------------RTCLHAAASGGNVECLNLLLSSGADLRRRD 453
Query: 248 VKGETPLDMALQN 260
G TPL A N
Sbjct: 454 KFGRTPLHYAAAN 466
Score = 72.4 bits (176), Expect = 1e-12
Identities = 61/226 (26%), Positives = 108/226 (47%), Gaps = 6/226 (2%)
Query: 35 LANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNR 94
L N +L + + + A G E K LV G D+ D++ LLH AA + +
Sbjct: 159 LLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQ 218
Query: 95 LDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIH 154
+++VK+ + GA +D+ +T LH A G + I L+ GA+ + +GF+ +H
Sbjct: 219 IEVVKYLLRMGAEIDEPNA-FGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLH 277
Query: 155 LAVLFQHMPI-IAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPS-LNVV 212
+A + + + + L++ G VN G++PL ++A + G +L N S ++
Sbjct: 278 VAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAA--IHGRFTRSQILIQNGSEIDCA 335
Query: 213 DKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMAL 258
DK NTPLH A G+ + L+ G+ + + PL +A+
Sbjct: 336 DKF-GNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAV 380
Score = 62.0 bits (149), Expect = 2e-09
Identities = 64/280 (22%), Positives = 113/280 (40%), Gaps = 68/280 (24%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A G E L+ +G D+R+ DK + LH+AA N ++ GA V++
Sbjct: 430 AASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCK- 488
Query: 116 NSTPLHWAIR-------QGHLPM---------------------VILLLQHGADPTLIDG 147
+PLH+A + H P + LL +GADP+L D
Sbjct: 489 GCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDR 548
Query: 148 EGFSSIHLAVLF-----------------------------------QHMPIIAYLISKG 172
+G++++H A + H + L
Sbjct: 549 QGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETL 608
Query: 173 QSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNA 232
++++ D G+T L L+ + E L S + ++ + TPLH A A+G+ ++
Sbjct: 609 VNLDVRDHKGRTALFLATERG-STECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDS 667
Query: 233 VDKLLEAGSSLDIQNVK---GETPLDMALQNKNQLIIHML 269
+ L+++G DI +V G+TPL +A+ N + +H+L
Sbjct: 668 LHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLL 707
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/140 (32%), Positives = 71/140 (50%), Gaps = 2/140 (1%)
Query: 118 TPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNM 177
TPLH A G +P++ LLL GA+ D + +H A ++ ++ L++ VN
Sbjct: 43 TPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNA 102
Query: 178 TDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLL 237
D QTPL ++A + L SLNV D+ ++ LH AV +G++ V+ LL
Sbjct: 103 RDKLWQTPLHVAAAN-RATKCAEALAPLLSSLNVADRSGRSA-LHHAVHSGHLETVNLLL 160
Query: 238 EAGSSLDIQNVKGETPLDMA 257
G+SL++ + K PL A
Sbjct: 161 NKGASLNVCDKKERQPLHWA 180
Score = 54.3 bits (129), Expect = 3e-07
Identities = 63/243 (25%), Positives = 96/243 (39%), Gaps = 8/243 (3%)
Query: 33 KELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPD-KENVSLLHWAAI 91
K LA L + + + AT+ G E + L G + K + LH AA
Sbjct: 602 KTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAA 661
Query: 92 NNRLDLVKFYISKG--AVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEG 149
+ D + I G A + + TPL AI GH+ V LLL+ G+ D G
Sbjct: 662 SGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRG 721
Query: 150 FSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSA---HKVIGPEPTGFLLKFN 206
+++H + +A L+ V D G+TP+ L++ H + L +
Sbjct: 722 RTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTD 781
Query: 207 PSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLII 266
P VD +P+HWA G+ + ++ LLE S TPL A+ N
Sbjct: 782 PLDAGVD-YSGYSPMHWASYTGHEDCLELLLE-HSPFSYLEGNPFTPLHCAVINNQDSTT 839
Query: 267 HML 269
ML
Sbjct: 840 EML 842
Score = 50.8 bits (120), Expect = 4e-06
Identities = 43/151 (28%), Positives = 69/151 (45%), Gaps = 2/151 (1%)
Query: 119 PLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMT 178
PL AI + V LL + ++D E + +H A +PI+ L+ G +VN
Sbjct: 11 PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70
Query: 179 DVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLE 238
D TPL +A + G LL + +N DK+ Q TPLH A A + L
Sbjct: 71 DTLWLTPLHRAAAS-RNEKVLGLLLAHSADVNARDKLWQ-TPLHVAAANRATKCAEALAP 128
Query: 239 AGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
SSL++ + G + L A+ + + +++L
Sbjct: 129 LLSSLNVADRSGRSALHHAVHSGHLETVNLL 159
Score = 48.1 bits (113), Expect = 2e-05
Identities = 47/182 (25%), Positives = 80/182 (43%), Gaps = 7/182 (3%)
Query: 86 LHWAAINNRLDLVKFYISK-GAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTL 144
LH A INN+ + + GA + TPLH A ++ + +LLQH A+
Sbjct: 827 LHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNA 886
Query: 145 IDGEGFSSIHLAVLFQHMPIIAYLISKGQS-VNMTDVNGQTPLMLSAHKVIGPEPTG-FL 202
D G +++ A + +L+ +G++ + + D N T L L+ K G E +
Sbjct: 887 TDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSK--GHEKCALMI 944
Query: 203 LKFNPSLNVVDKIHQ--NTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQN 260
L L +++ + PLH A G + V LL G+++ + +G TP N
Sbjct: 945 LAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPN 1004
Query: 261 KN 262
K+
Sbjct: 1005 KD 1006
Score = 44.7 bits (104), Expect = 3e-04
Identities = 72/281 (25%), Positives = 109/281 (38%), Gaps = 54/281 (19%)
Query: 50 NCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKG---A 106
N + A +YG L+ G D + ++ LH A + D + +S G +
Sbjct: 340 NTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYS 399
Query: 107 VVDQL--------GGDLNS------TPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSS 152
+V L G D+N+ T LH A G++ + LLL GAD D G +
Sbjct: 400 IVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTP 459
Query: 153 IHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLML---------------SAHKVIGPE 197
+H A L++ G VN D G +PL S+H E
Sbjct: 460 LHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHTPSSHDAEEDE 519
Query: 198 P--------TGFLLKF------NPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSL 243
P F L+F +PSL D+ T +H+A A GN ++ LLE +
Sbjct: 520 PLKESRRKEAFFCLEFLLDNGADPSLR--DR-QGYTAVHYAAAYGNRQNLELLLEMSFNC 576
Query: 244 --DIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRANQKFR 282
D+++ +PL +A N + LKT A+ N R
Sbjct: 577 LEDVESTIPVSPLHLAAYNGH---CEALKTLAETLVNLDVR 614
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/214 (25%), Positives = 84/214 (39%), Gaps = 12/214 (5%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNS-TPLHWAIRQ 126
L+E G D + LH A+ D + + A V L D TP+H A
Sbjct: 707 LLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFV--LCRDFKGRTPIHLASAC 764
Query: 127 GHLPMVILLLQHG--ADP--TLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNG 182
GH ++ LLQ DP +D G+S +H A H + L+ + + N
Sbjct: 765 GHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSP-FSYLEGNP 823
Query: 183 QTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDK--IHQNTPLHWAVAAGNVNAVDKLLEAG 240
TPL + + + T +L +V+ TPLH A A NV+ + LL+
Sbjct: 824 FTPLHCAV--INNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQ 881
Query: 241 SSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAK 274
+ ++ + G T L A +N + L K
Sbjct: 882 AEVNATDHTGRTALMTAAENGQTAAVEFLLYRGK 915
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/84 (28%), Positives = 48/84 (57%), Gaps = 2/84 (2%)
Query: 202 LLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNK 261
LL ++NV+D+ + TPLH A G+V + LL +G++++ ++ TPL A ++
Sbjct: 27 LLSQKENINVLDQ-ERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASR 85
Query: 262 NQLIIHMLKTEAKMRANQKFRLWR 285
N+ ++ +L + N + +LW+
Sbjct: 86 NEKVLGLLLAHS-ADVNARDKLWQ 108
Score = 39.7 bits (91), Expect = 0.008
Identities = 31/126 (24%), Positives = 55/126 (43%), Gaps = 3/126 (2%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQG 127
L++ +V D + L AA N + V+F + +G + + +T LH A +G
Sbjct: 877 LLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKG 936
Query: 128 HLPMVILLLQHGADPTLIDGEGFS---SIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQT 184
H +++L D LI+ + +H+A ++ L+S G +V D G T
Sbjct: 937 HEKCALMILAETQDLGLINATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHT 996
Query: 185 PLMLSA 190
P + A
Sbjct: 997 PALACA 1002
Score = 30.8 bits (68), Expect = 3.9
Identities = 31/95 (32%), Positives = 38/95 (40%), Gaps = 22/95 (23%)
Query: 119 PLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMT 178
PLH A R G +V LL HGA +D EG H P +A +K
Sbjct: 964 PLHIAARNGLASVVQALLSHGATVLAVDEEG-----------HTPALACAPNK------- 1005
Query: 179 DVNGQTPLMLSAHKVIGPE----PTGFLLKFNPSL 209
DV L+LS K P+ P F L N S+
Sbjct: 1006 DVADCLALILSTMKPFPPKDAVSPFSFSLLKNCSI 1040
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 81.6 bits (200), Expect = 2e-15
Identities = 63/212 (29%), Positives = 103/212 (48%), Gaps = 4/212 (1%)
Query: 46 EDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKG 105
+ S + A Q G E C L++AG ++ DK+ + L A +NN L++ ++ + +G
Sbjct: 648 QQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRG 707
Query: 106 AVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHG-ADPTLIDGEGFSSIHLAVLFQHMPI 164
V D ST LH A + G+L MV LLL G D D G++ I A +H+ +
Sbjct: 708 GCVYSKEED-GSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEV 766
Query: 165 IAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWA 224
I L+++G V +TD N + + A LL L+ V+ H +TPLH A
Sbjct: 767 IRMLLTRGADVTLTD-NEENICLHWASFTGSAAIAEVLLNARCDLHAVN-YHGDTPLHIA 824
Query: 225 VAAGNVNAVDKLLEAGSSLDIQNVKGETPLDM 256
+ V L G++ +++N +G+T D+
Sbjct: 825 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 856
Score = 48.1 bits (113), Expect = 2e-05
Identities = 43/158 (27%), Positives = 75/158 (47%), Gaps = 11/158 (6%)
Query: 120 LHWAIRQGHLPMVILLLQHGADPTLIDGEGF--SSIHLAVLFQHMPIIAYLISKGQSVNM 177
L+ +++QG L VIL+L DP + + +H A + I L+ G ++N
Sbjct: 620 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 679
Query: 178 TDVNGQTPLM---LSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVD 234
D +TPLM ++ H E ++++ + ++ +T LH A GN+ V
Sbjct: 680 VDKQQRTPLMEAVVNNHL----EVARYMVQRGGCVYSKEE-DGSTCLHHAAKIGNLEMVS 734
Query: 235 KLLEAGS-SLDIQNVKGETPLDMALQNKNQLIIHMLKT 271
LL G ++ Q+ G TP+ A ++K+ +I ML T
Sbjct: 735 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 772
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 81.6 bits (200), Expect = 2e-15
Identities = 63/212 (29%), Positives = 103/212 (48%), Gaps = 4/212 (1%)
Query: 46 EDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKG 105
+ S + A Q G E C L++AG ++ DK+ + L A +NN L++ ++ + +G
Sbjct: 682 QQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEVARYMVQRG 741
Query: 106 AVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHG-ADPTLIDGEGFSSIHLAVLFQHMPI 164
V D ST LH A + G+L MV LLL G D D G++ I A +H+ +
Sbjct: 742 GCVYSKEED-GSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEV 800
Query: 165 IAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWA 224
I L+++G V +TD N + + A LL L+ V+ H +TPLH A
Sbjct: 801 IRMLLTRGADVTLTD-NEENICLHWASFTGSAAIAEVLLNARCDLHAVN-YHGDTPLHIA 858
Query: 225 VAAGNVNAVDKLLEAGSSLDIQNVKGETPLDM 256
+ V L G++ +++N +G+T D+
Sbjct: 859 ARESYHDCVLLFLSRGANPELRNKEGDTAWDL 890
Score = 48.1 bits (113), Expect = 2e-05
Identities = 43/158 (27%), Positives = 75/158 (47%), Gaps = 11/158 (6%)
Query: 120 LHWAIRQGHLPMVILLLQHGADPTLIDGEGF--SSIHLAVLFQHMPIIAYLISKGQSVNM 177
L+ +++QG L VIL+L DP + + +H A + I L+ G ++N
Sbjct: 654 LYLSVKQGELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINA 713
Query: 178 TDVNGQTPLM---LSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVD 234
D +TPLM ++ H E ++++ + ++ +T LH A GN+ V
Sbjct: 714 VDKQQRTPLMEAVVNNHL----EVARYMVQRGGCVYSKEE-DGSTCLHHAAKIGNLEMVS 768
Query: 235 KLLEAGS-SLDIQNVKGETPLDMALQNKNQLIIHMLKT 271
LL G ++ Q+ G TP+ A ++K+ +I ML T
Sbjct: 769 LLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLT 806
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 81.6 bits (200), Expect = 2e-15
Identities = 65/230 (28%), Positives = 111/230 (48%), Gaps = 10/230 (4%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A++ G K L++ G + ++ ++ LH A + +V+ + + A + L
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI--LSKTK 332
Query: 116 NS-TPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQS 174
N +PLH A + HL V LLLQH + + +++H+A H + L+ K +
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
Query: 175 VNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVD 234
N +NG TPL ++ K + LLK S+ V + TP+H A G+VN V
Sbjct: 393 PNAKALNGFTPLHIACKKN-RIKVMELLLKHGASIQAVTESGL-TPIHVAAFMGHVNIVS 450
Query: 235 KLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML-----KTEAKMRANQ 279
+L+ G+S + NV+GET L MA ++ ++ L + EAK + +Q
Sbjct: 451 QLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ 500
Score = 80.1 bits (196), Expect = 6e-15
Identities = 57/214 (26%), Positives = 104/214 (48%), Gaps = 3/214 (1%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A +YG E L++ K ++ LH AA + + + +GA +
Sbjct: 572 AAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN- 630
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH A ++ + + LL++GAD + +G +S+HLA H+ +++ L+ + +V
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANV 690
Query: 176 NMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDK 235
N+++ +G TPL L+A + L+ ++ K+ TPLH GN+ V+
Sbjct: 691 NLSNKSGLTPLHLAAQE-DRVNVAEVLVNQGAHVDAQTKMGY-TPLHVGCHYGNIKIVNF 748
Query: 236 LLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
LL+ + ++ + G TPL A Q + II++L
Sbjct: 749 LLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVL 782
Score = 77.8 bits (190), Expect = 3e-14
Identities = 62/226 (27%), Positives = 107/226 (47%), Gaps = 7/226 (3%)
Query: 41 ALPLIEDSSN--CDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLV 98
A P++ + N + ATQ + L++ V + ++ LH AA +
Sbjct: 324 AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVA 383
Query: 99 KFYISKGAVVDQLGGDLNS-TPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAV 157
K + K A + LN TPLH A ++ + ++ LLL+HGA + G + IH+A
Sbjct: 384 KVLLDKKANPNAKA--LNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAA 441
Query: 158 LFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQ 217
H+ I++ L+ G S N T+V G+T L ++A E +L++ + K Q
Sbjct: 442 FMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSG-QAEVVRYLVQDGAQVEAKAKDDQ 500
Query: 218 NTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQ 263
TPLH + G + V +LL+ G+S + G TPL ++ + ++
Sbjct: 501 -TPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHE 545
Score = 77.0 bits (188), Expect = 5e-14
Identities = 63/218 (28%), Positives = 100/218 (45%), Gaps = 7/218 (3%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A+ G E K LV G +V + + L+ AA N L++VKF + GA L +
Sbjct: 114 ASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGAS-QSLATED 172
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPL A++QGH +V LLL++ + ++H+A A L+ +
Sbjct: 173 GFTPLAVALQQGHDQVVSLLLENDTKGKV----RLPALHIAARKDDTKAAALLLQNDNNA 228
Query: 176 NMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDK 235
++ +G TPL ++AH G LL + + TPLH A GN N V
Sbjct: 229 DVESKSGFTPLHIAAH--YGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKL 286
Query: 236 LLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKTEA 273
LL+ G+ +D + G TPL ++ ++ ++ ML A
Sbjct: 287 LLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
Score = 73.9 bits (180), Expect = 4e-13
Identities = 64/246 (26%), Positives = 109/246 (44%), Gaps = 34/246 (13%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A + G E + LV+ G V K++ + LH +A + D+V+ + +GA +
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTS- 531
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH + R+GH + LL HGA ++ +GF+ +H+A + + + L+ K S
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASP 591
Query: 176 NMTDVNGQTPLMLSAH----KVI------GPEP-----TGF-----------------LL 203
+ +G TPL ++AH KV G P G+ LL
Sbjct: 592 DAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLL 651
Query: 204 KFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQ 263
++ N V + +H A G+V+ V LL +++++ N G TPL +A Q
Sbjct: 652 EYGADANAVTR-QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRV 710
Query: 264 LIIHML 269
+ +L
Sbjct: 711 NVAEVL 716
Score = 73.2 bits (178), Expect = 7e-13
Identities = 62/265 (23%), Positives = 119/265 (44%), Gaps = 37/265 (13%)
Query: 46 EDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKG 105
+ +N ++A + G E+ + ++ G D+ ++ ++ LH A+ +++V + +
Sbjct: 38 KSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQRE 97
Query: 106 AVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPII 165
A VD +T LH A G +V +L+ +GA+ GF+ +++A H+ ++
Sbjct: 98 ANVD-AATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156
Query: 166 AYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFN--------PSLNVVDK--- 214
+L+ G S ++ +G TPL ++ + G + LL N P+L++ +
Sbjct: 157 KFLLDNGASQSLATEDGFTPLAVALQQ--GHDQVVSLLLENDTKGKVRLPALHIAARKDD 214
Query: 215 ------IHQN------------TPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDM 256
+ QN TPLH A GN+N LL +++D TPL +
Sbjct: 215 TKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHV 274
Query: 257 ALQNKNQLIIHML-----KTEAKMR 276
A + N ++ +L K +AK R
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTR 299
Score = 72.4 bits (176), Expect = 1e-12
Identities = 54/194 (27%), Positives = 92/194 (47%), Gaps = 11/194 (5%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQG 127
L++ G K + LH AA N++D+ + GA + + +H A ++G
Sbjct: 617 LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQ-GIASVHLAAQEG 675
Query: 128 HLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLM 187
H+ MV LLL A+ L + G + +HLA + + L+++G V+ G TPL
Sbjct: 676 HVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLH 735
Query: 188 LSAH----KVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSL 243
+ H K++ FLL+ + +N K + TPLH A G+ + ++ LL+ +S
Sbjct: 736 VGCHYGNIKIVN-----FLLQHSAKVNAKTK-NGYTPLHQAAQQGHTHIINVLLQNNASP 789
Query: 244 DIQNVKGETPLDMA 257
+ V G T L +A
Sbjct: 790 NELTVNGNTALGIA 803
Score = 63.2 bits (152), Expect = 7e-10
Identities = 52/214 (24%), Positives = 95/214 (44%), Gaps = 10/214 (4%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQG 127
L++ + K +S LH A + L+ V+ + VD + D T LH A G
Sbjct: 320 LLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDY-LTALHVAAHCG 378
Query: 128 HLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLM 187
H + +LL A+P GF+ +H+A + ++ L+ G S+ +G TP+
Sbjct: 379 HYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIH 438
Query: 188 LSA---HKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLD 244
++A H I + L+ S N + + T LH A +G V L++ G+ ++
Sbjct: 439 VAAFMGHVNIVSQ----LMHHGASPNTTN-VRGETALHMAARSGQAEVVRYLVQDGAQVE 493
Query: 245 IQNVKGETPLDMALQ-NKNQLIIHMLKTEAKMRA 277
+ +TPL ++ + K ++ +L+ A A
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQQGASPNA 527
Score = 58.9 bits (141), Expect = 1e-08
Identities = 40/131 (30%), Positives = 62/131 (47%), Gaps = 1/131 (0%)
Query: 56 ATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDL 115
A Q G + L+ +V +K ++ LH AA +R+++ + +++GA VD +
Sbjct: 671 AAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT-KM 729
Query: 116 NSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSV 175
TPLH G++ +V LLQH A G++ +H A H II L+ S
Sbjct: 730 GYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASP 789
Query: 176 NMTDVNGQTPL 186
N VNG T L
Sbjct: 790 NELTVNGNTAL 800
Score = 56.2 bits (134), Expect = 9e-08
Identities = 50/200 (25%), Positives = 92/200 (46%), Gaps = 6/200 (3%)
Query: 80 KENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHG 139
K + LH AA +++ +++ A VD + + TPLH A ++G+ MV LLL G
Sbjct: 233 KSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN-DITPLHVASKRGNANMVKLLLDRG 291
Query: 140 ADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPT 199
A +G + +H H ++ L+ + + NG +PL ++ G
Sbjct: 292 AKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQ---GDHLN 348
Query: 200 GFLLKFNPSLNVVDKIHQN-TPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMAL 258
L ++ V D + T LH A G+ LL+ ++ + + + G TPL +A
Sbjct: 349 CVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIAC 408
Query: 259 -QNKNQLIIHMLKTEAKMRA 277
+N+ +++ +LK A ++A
Sbjct: 409 KKNRIKVMELLLKHGASIQA 428
Score = 54.3 bits (129), Expect = 3e-07
Identities = 52/207 (25%), Positives = 89/207 (42%), Gaps = 42/207 (20%)
Query: 74 DVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGD-LNSTPLHWAIRQGHLPMV 132
D ++ N S L AA L+ YI G ++ + LN+ LH A ++GH+ +V
Sbjct: 34 DRKKKSDANASYLR-AARAGHLEKALDYIKNGVDINICNQNGLNA--LHLASKEGHVEVV 90
Query: 133 ILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHK 192
LLQ A+ +G +++H+A L ++ L++ G +VN NG TPL ++A +
Sbjct: 91 SELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQE 150
Query: 193 VIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGET 252
++ V LL+ G+S + G T
Sbjct: 151 -----------------------------------NHLEVVKFLLDNGASQSLATEDGFT 175
Query: 253 PLDMALQNKNQLIIHML---KTEAKMR 276
PL +ALQ + ++ +L T+ K+R
Sbjct: 176 PLAVALQQGHDQVVSLLLENDTKGKVR 202
Score = 39.7 bits (91), Expect = 0.008
Identities = 33/130 (25%), Positives = 57/130 (43%), Gaps = 7/130 (5%)
Query: 68 LVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQG 127
LV G V K + LH + +V F + A V+ + TPLH A +QG
Sbjct: 716 LVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKN-GYTPLHQAAQQG 774
Query: 128 HLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLM 187
H ++ +LLQ+ A P + G +++ +A ++ ++ L +T+ T +
Sbjct: 775 HTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL------KIVTEETMTTTTV 828
Query: 188 LSAHKVIGPE 197
HK+ PE
Sbjct: 829 TEKHKMNVPE 838
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 81.3 bits (199), Expect = 3e-15
Identities = 67/230 (29%), Positives = 108/230 (46%), Gaps = 7/230 (3%)
Query: 45 IEDS-SNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYIS 103
IED+ + + A + G + L+ G ++ D++ + L AA ++V +
Sbjct: 573 IEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLY 632
Query: 104 KGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMP 163
G VD D + T L A GH +V+ LLQHGA+ D EG +++ A H
Sbjct: 633 AGVKVDCADAD-SRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHRE 691
Query: 164 IIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPE----PTGFLLKFNPSLNVVDKIHQNT 219
I+ +L+ G VN DV+G+T L ++A V + L+ ++ DK T
Sbjct: 692 IVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDK-DGMT 750
Query: 220 PLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
PL A G+V+ VD LLE G+ +D + G TPL A + +++ L
Sbjct: 751 PLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTL 800
Score = 70.9 bits (172), Expect = 3e-12
Identities = 53/205 (25%), Positives = 93/205 (45%), Gaps = 3/205 (1%)
Query: 65 CKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAI 124
C+ L+E G + D + A+ D V+ + + +DQ G D L A
Sbjct: 863 CEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYD-GRNALRVAA 921
Query: 125 RQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQT 184
+GH +V LL HGAD D +G ++++ L + + Y + G +V +D G+T
Sbjct: 922 LEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRT 981
Query: 185 PLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLD 244
L +S + E L+ ++ +N D + + L A G+V V L+E G+ +D
Sbjct: 982 ALHVSCWQG-HMEMVQVLIAYHADVNAADN-EKRSALQSAAWQGHVKVVQLLIEHGAVVD 1039
Query: 245 IQNVKGETPLDMALQNKNQLIIHML 269
+G T L +A Q + ++ +L
Sbjct: 1040 HTCNQGATALCIAAQEGHIDVVQVL 1064
Score = 63.2 bits (152), Expect = 7e-10
Identities = 58/236 (24%), Positives = 101/236 (42%), Gaps = 45/236 (19%)
Query: 44 LIEDSSNCDIV-----KATQYGIFERCKELVEA----GYDVRQPDKENVSLLHWAAINNR 94
L+E+ SN D A + E +++VE G DV D + L+ A+ N+
Sbjct: 899 LLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958
Query: 95 LDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIH 154
L + ++++ GA V+ + T LH + QGH+ MV +L+ + AD D E S++
Sbjct: 959 LTMAEYFLENGANVEASDAE-GRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQ 1017
Query: 155 LAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDK 214
A H+ ++ LI G V+ T G T L ++A +
Sbjct: 1018 SAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQE---------------------- 1055
Query: 215 IHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLK 270
G+++ V LLE G+ + + G T + +A +N + II +L+
Sbjct: 1056 -------------GHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLE 1098
Score = 62.8 bits (151), Expect = 9e-10
Identities = 63/237 (26%), Positives = 106/237 (44%), Gaps = 17/237 (7%)
Query: 53 IVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAI-----NNRLDLVKFYISKGAV 107
++ A G E + L++ G +V D + + L AA+ +V I +GA
Sbjct: 681 LIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAE 740
Query: 108 VDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAY 167
VD D TPL A +GH+ +V LLL+ GAD D G + + A H ++
Sbjct: 741 VDHCDKD-GMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNT 799
Query: 168 LISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFLLKFNPSLNVVDKIHQN----TPLHW 223
L+ G +V+ D G+T L +++ + E LL +D+ H++ TPLH
Sbjct: 800 LLFWGAAVDSIDSEGRTVLSIASAQG-NVEVVRTLLD-----RGLDENHRDDAGWTPLHM 853
Query: 224 AVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKTEAKMRANQK 280
A G+ + L+E G+ + + G P +A Q + + +L E K +Q+
Sbjct: 854 AAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQIL-LENKSNIDQR 909
Score = 57.8 bits (138), Expect = 3e-08
Identities = 43/126 (34%), Positives = 61/126 (48%), Gaps = 5/126 (3%)
Query: 60 GIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTP 119
G E + L+ DV D E S L AA + +V+ I GAVVD +T
Sbjct: 990 GHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQ-GATA 1048
Query: 120 LHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTD 179
L A ++GH+ +V +LL+HGADP D G +++ +A H II L G S
Sbjct: 1049 LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS----S 1104
Query: 180 VNGQTP 185
+NG +P
Sbjct: 1105 LNGCSP 1110
Score = 47.8 bits (112), Expect = 3e-05
Identities = 48/228 (21%), Positives = 98/228 (42%), Gaps = 11/228 (4%)
Query: 46 EDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVKFYISKG 105
+++ ++ A G L+ G V D E ++L A+ +++V+ + +G
Sbjct: 778 DNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRG 837
Query: 106 AVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPII 165
+ + D TPLH A +GH + L++ GA ID +G LA H +
Sbjct: 838 -LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCV 896
Query: 166 AYLISKGQSVNMTDVNGQTPLMLSA---HKVIGPEPTGFLLKFNPSLNVVDKIHQNTPLH 222
L+ +++ +G+ L ++A H+ I L F+ +V K P
Sbjct: 897 QILLENKSNIDQRGYDGRNALRVAALEGHRDI------VELLFSHGADVNCKDADGRPTL 950
Query: 223 WAVAAGN-VNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHML 269
+ +A N + + LE G++++ + +G T L ++ + ++ +L
Sbjct: 951 YILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
Score = 43.5 bits (101), Expect = 6e-04
Identities = 60/254 (23%), Positives = 101/254 (39%), Gaps = 18/254 (7%)
Query: 33 KELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAIN 92
K L NA E ++ S C T E L+ + + E L W N
Sbjct: 424 KYLCNAAEGHRMLAMSYTCQAKNLTPLEAQEFALHLINSNLQL-----ETAELALWMIWN 478
Query: 93 NR--LDLVKFYISKGAVVDQL----GGDLNSTPLHWA--IRQG--HLPMVILLLQHGADP 142
D + I K V QL G +NS + +RQ + LL +GA
Sbjct: 479 GTPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASV 538
Query: 143 TLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVIGPEPTGFL 202
D G + + A + ++ L+S+G + + D +G TPL L+A + + L
Sbjct: 539 NQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQG-HTKVVNCL 597
Query: 203 LKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKN 262
+ ++N D+ T L A G+ V LL AG +D + T L A +
Sbjct: 598 IGCGANINHTDQ-DGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGH 656
Query: 263 Q-LIIHMLKTEAKM 275
+ +++++L+ A++
Sbjct: 657 EDIVLNLLQHGAEV 670
>gi|134133226 protein expressed in prostate, ovary, testis, and
placenta 2 [Homo sapiens]
Length = 1075
Score = 80.9 bits (198), Expect = 3e-15
Identities = 53/196 (27%), Positives = 99/196 (50%), Gaps = 3/196 (1%)
Query: 74 DVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVI 133
DV + DK+ + LH A+ N ++VK + + ++ L T L A++ +
Sbjct: 165 DVNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNVLDNK-KRTALIKAVQCQEDECAL 223
Query: 134 LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKV 193
+LL+HG DP + D G +++H A+ + + L+ G + + +G TPL+L H+
Sbjct: 224 MLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQ 283
Query: 194 IGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETP 253
+ FL+K +LN +D+ + T L AV G+ + V LLE + Q++ G+T
Sbjct: 284 -KQQVVKFLIKKKANLNALDR-YGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTA 341
Query: 254 LDMALQNKNQLIIHML 269
+ A+ + + +I +L
Sbjct: 342 REYAVSSHHHVICQLL 357
Score = 48.9 bits (115), Expect = 1e-05
Identities = 39/152 (25%), Positives = 71/152 (46%), Gaps = 1/152 (0%)
Query: 33 KELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAIN 92
K L + R L ++++ ++KA Q E L+E G D PD+ + LH+A N
Sbjct: 190 KLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYN 249
Query: 93 NRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSS 152
+ K + GA ++ TPL + + +V L++ A+ +D G ++
Sbjct: 250 EDKLMAKALLLYGADIESKNKH-GLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTA 308
Query: 153 IHLAVLFQHMPIIAYLISKGQSVNMTDVNGQT 184
+ LAV I++ L+ + V+ D++GQT
Sbjct: 309 LILAVCCGSASIVSLLLEQNIDVSSQDLSGQT 340
>gi|209977003 ANKRD26-like family C, member 3 [Homo sapiens]
Length = 545
Score = 80.9 bits (198), Expect = 3e-15
Identities = 52/196 (26%), Positives = 100/196 (51%), Gaps = 3/196 (1%)
Query: 74 DVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVI 133
D+ + DK+ + LH A+ N ++VK + + ++ L T L A++ +
Sbjct: 202 DMNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNILDNK-KRTALTKAVQCQEDECAL 260
Query: 134 LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKV 193
+LL+HG DP + D G +++H A+ + + L+ G + + +G TPL+L H+
Sbjct: 261 MLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQ 320
Query: 194 IGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETP 253
+ FL+K +LN +D+ + T L AV G+ + V LLE + Q++ G+T
Sbjct: 321 -KQQVVKFLIKKKANLNALDR-YGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTA 378
Query: 254 LDMALQNKNQLIIHML 269
+ A+ +++ +I +L
Sbjct: 379 REYAVSSRHNVICQLL 394
Score = 48.9 bits (115), Expect = 1e-05
Identities = 43/165 (26%), Positives = 75/165 (45%), Gaps = 4/165 (2%)
Query: 33 KELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAIN 92
K L + R L ++++ + KA Q E L+E G D PD+ + LH+A N
Sbjct: 227 KLLLDRRCQLNILDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYN 286
Query: 93 NRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSS 152
+ K + GA ++ TPL + + +V L++ A+ +D G ++
Sbjct: 287 EDKLMAKALLLYGADIESKNKH-GLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTA 345
Query: 153 IHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTP---LMLSAHKVI 194
+ LAV I++ L+ + V+ D++GQT + S H VI
Sbjct: 346 LILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSRHNVI 390
>gi|153791352 prostate, ovary, testis expressed protein on
chromosome 2 [Homo sapiens]
Length = 1075
Score = 80.9 bits (198), Expect = 3e-15
Identities = 53/196 (27%), Positives = 99/196 (50%), Gaps = 3/196 (1%)
Query: 74 DVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVI 133
DV + DK+ + LH A+ N ++VK + + ++ L T L A++ +
Sbjct: 165 DVNKQDKQKRTALHLASANGNSEVVKLLLDRRCQLNVLDNK-KRTALIKAVQCQEDECAL 223
Query: 134 LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKV 193
+LL+HG DP + D G +++H A+ + + L+ G + + +G TPL+L H+
Sbjct: 224 MLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQ 283
Query: 194 IGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETP 253
+ FL+K +LN +D+ + T L AV G+ + V LLE + Q++ G+T
Sbjct: 284 -KQQVVKFLIKKKANLNALDR-YGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTA 341
Query: 254 LDMALQNKNQLIIHML 269
+ A+ + + +I +L
Sbjct: 342 REYAVSSHHHVICQLL 357
Score = 48.9 bits (115), Expect = 1e-05
Identities = 39/152 (25%), Positives = 71/152 (46%), Gaps = 1/152 (0%)
Query: 33 KELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAIN 92
K L + R L ++++ ++KA Q E L+E G D PD+ + LH+A N
Sbjct: 190 KLLLDRRCQLNVLDNKKRTALIKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYN 249
Query: 93 NRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSS 152
+ K + GA ++ TPL + + +V L++ A+ +D G ++
Sbjct: 250 EDKLMAKALLLYGADIESKNKH-GLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTA 308
Query: 153 IHLAVLFQHMPIIAYLISKGQSVNMTDVNGQT 184
+ LAV I++ L+ + V+ D++GQT
Sbjct: 309 LILAVCCGSASIVSLLLEQNIDVSSQDLSGQT 340
>gi|224282147 prostate-specific P704P [Homo sapiens]
Length = 508
Score = 80.5 bits (197), Expect = 4e-15
Identities = 52/196 (26%), Positives = 100/196 (51%), Gaps = 3/196 (1%)
Query: 74 DVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVI 133
D+ + DK+ + LH A+ N ++VK + + ++ L T L A++ +
Sbjct: 165 DMNKKDKQKRTALHLASANGNSEVVKLLLDRRCQLNILDNK-KRTALTKAVQCQEDECAL 223
Query: 134 LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKV 193
+LL+HG DP + D G +++H A+ + + L+ G + + +G TPL+L H+
Sbjct: 224 MLLEHGTDPNIPDEYGNTALHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQ 283
Query: 194 IGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETP 253
+ FL+K +LN +D+ + T L AV G+ + V LLE + Q++ G+T
Sbjct: 284 -KQQVVKFLIKKKANLNALDR-YGRTVLILAVCCGSASIVSLLLEQNIDVSSQDLSGQTA 341
Query: 254 LDMALQNKNQLIIHML 269
+ A+ +++ +I +L
Sbjct: 342 REYAVSSRHNVICQLL 357
Score = 47.8 bits (112), Expect = 3e-05
Identities = 43/165 (26%), Positives = 74/165 (44%), Gaps = 4/165 (2%)
Query: 33 KELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAIN 92
K L + R L ++++ + KA Q E L+E G D PD+ + LH+A N
Sbjct: 190 KLLLDRRCQLNILDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTALHYAIYN 249
Query: 93 NRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSS 152
+ K + GA ++ TPL + + +V L++ A+ +D G +
Sbjct: 250 EDKLMAKALLLYGADIESKNKH-GLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTV 308
Query: 153 IHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTP---LMLSAHKVI 194
+ LAV I++ L+ + V+ D++GQT + S H VI
Sbjct: 309 LILAVCCGSASIVSLLLEQNIDVSSQDLSGQTAREYAVSSRHNVI 353
>gi|37594447 Abl-philin 2 isoform 4 [Homo sapiens]
Length = 296
Score = 80.5 bits (197), Expect = 4e-15
Identities = 52/180 (28%), Positives = 85/180 (47%), Gaps = 13/180 (7%)
Query: 412 NIITLAETGSLDFRT--FCTSCLIRKPLRSLHCHVCNCCVARYDQHCLWTGRCIGFGNHH 469
N+I G D T C C+ KP R+ HC +CN CV + D HC W C+G NH
Sbjct: 74 NVIRWFGVGRNDIATVSICKKCIYPKPARTHHCSICNRCVLKMDHHCPWLNNCVGHYNHR 133
Query: 470 YYIFFLFFLSMVCGWIIYGSF-IYLSSHCA-TTFKEDGLWTYLNQIVACSPWVLYILMLA 527
Y+ F FF+++ C + YGS+ ++ ++ A T+ + T+ + ++Y+ L
Sbjct: 134 YFFSFCFFMTLGCVYCSYGSWDLFREAYAAIETYHQTPPPTFSFRERMTHKSLVYLWFLC 193
Query: 528 TFHFSWSTFLLLNQL----FQIAFLGLTSHERISLQKQSKHMKQTLSLRKTPYNLGFMQN 583
+ S L L L + G TS ER +K+ + ++ + + PYN G + N
Sbjct: 194 S-----SVALALGALTVWHAVLISRGETSIERHINKKERRRLQAKGRVFRNPYNYGCLDN 248
>gi|113413200 PREDICTED: similar to protein expressed in prostate,
ovary, testis, and placenta 2 [Homo sapiens]
Length = 1038
Score = 80.1 bits (196), Expect = 6e-15
Identities = 53/196 (27%), Positives = 98/196 (50%), Gaps = 3/196 (1%)
Query: 74 DVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVI 133
DV + DK+ + LH A+ N +VK + + ++ L T L A++ +
Sbjct: 128 DVNKQDKQKRTALHLASANGNSGVVKLLLDRRCQLNVLDNK-KRTALTKAVQCQEDECAL 186
Query: 134 LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKV 193
+LL+HG DP + D G +++H A+ + + L+ G + + +G TPL+L H+
Sbjct: 187 MLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQ 246
Query: 194 IGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETP 253
+ FL+K +LN +D+ + T L AV G+ + V LLE + Q++ G+T
Sbjct: 247 -KQQVVKFLIKKKANLNALDR-YGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTA 304
Query: 254 LDMALQNKNQLIIHML 269
+ A+ + + +I +L
Sbjct: 305 REYAVSSHHHVICQLL 320
Score = 47.8 bits (112), Expect = 3e-05
Identities = 39/152 (25%), Positives = 70/152 (46%), Gaps = 1/152 (0%)
Query: 33 KELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAIN 92
K L + R L ++++ + KA Q E L+E G D PD+ + LH+A N
Sbjct: 153 KLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYN 212
Query: 93 NRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSS 152
+ K + GA ++ TPL + + +V L++ A+ +D G ++
Sbjct: 213 EDKLMAKALLLYGADIESKNKH-GLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTA 271
Query: 153 IHLAVLFQHMPIIAYLISKGQSVNMTDVNGQT 184
+ LAV I++ L+ + V+ D++GQT
Sbjct: 272 LILAVCCGSASIVSLLLEQNIDVSSQDLSGQT 303
>gi|239741769 PREDICTED: similar to protein expressed in prostate,
ovary, testis, and placenta 2 [Homo sapiens]
Length = 952
Score = 80.1 bits (196), Expect = 6e-15
Identities = 53/196 (27%), Positives = 98/196 (50%), Gaps = 3/196 (1%)
Query: 74 DVRQPDKENVSLLHWAAINNRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVI 133
DV + DK+ + LH A+ N +VK + + ++ L T L A++ +
Sbjct: 165 DVNKQDKQKRTALHLASANGNSGVVKLLLDRRCQLNVLDNK-KRTALTKAVQCQEDECAL 223
Query: 134 LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKV 193
+LL+HG DP + D G +++H A+ + + L+ G + + +G TPL+L H+
Sbjct: 224 MLLEHGTDPNIPDEYGNTTLHYAIYNEDKLMAKALLLYGADIESKNKHGLTPLLLGVHEQ 283
Query: 194 IGPEPTGFLLKFNPSLNVVDKIHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETP 253
+ FL+K +LN +D+ + T L AV G+ + V LLE + Q++ G+T
Sbjct: 284 -KQQVVKFLIKKKANLNALDR-YGRTALILAVCCGSASIVSLLLEQNIDVSSQDLSGQTA 341
Query: 254 LDMALQNKNQLIIHML 269
+ A+ + + +I +L
Sbjct: 342 REYAVSSHHHVICQLL 357
Score = 47.8 bits (112), Expect = 3e-05
Identities = 39/152 (25%), Positives = 70/152 (46%), Gaps = 1/152 (0%)
Query: 33 KELANAREALPLIEDSSNCDIVKATQYGIFERCKELVEAGYDVRQPDKENVSLLHWAAIN 92
K L + R L ++++ + KA Q E L+E G D PD+ + LH+A N
Sbjct: 190 KLLLDRRCQLNVLDNKKRTALTKAVQCQEDECALMLLEHGTDPNIPDEYGNTTLHYAIYN 249
Query: 93 NRLDLVKFYISKGAVVDQLGGDLNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSS 152
+ K + GA ++ TPL + + +V L++ A+ +D G ++
Sbjct: 250 EDKLMAKALLLYGADIESKNKH-GLTPLLLGVHEQKQQVVKFLIKKKANLNALDRYGRTA 308
Query: 153 IHLAVLFQHMPIIAYLISKGQSVNMTDVNGQT 184
+ LAV I++ L+ + V+ D++GQT
Sbjct: 309 LILAVCCGSASIVSLLLEQNIDVSSQDLSGQT 340
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.328 0.141 0.461
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,154,179
Number of Sequences: 37866
Number of extensions: 1058654
Number of successful extensions: 6371
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 347
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 2883
Number of HSP's gapped (non-prelim): 1574
length of query: 622
length of database: 18,247,518
effective HSP length: 108
effective length of query: 514
effective length of database: 14,157,990
effective search space: 7277206860
effective search space used: 7277206860
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.