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Search of human proteins with 4758700
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758700 mitogen-activated protein kinase-activated protein
kinase 3 [Homo sapiens]
(382 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758700 mitogen-activated protein kinase-activated protein ki... 793 0.0
gi|32481209 mitogen-activated protein kinase-activated protein k... 535 e-152
gi|10863901 mitogen-activated protein kinase-activated protein k... 484 e-137
gi|21237768 MAP kinase-activated protein kinase 5 isoform 2 [Hom... 263 1e-70
gi|21237765 MAP kinase-activated protein kinase 5 isoform 1 [Hom... 263 1e-70
gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo... 199 3e-51
gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo s... 191 7e-49
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 191 1e-48
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 191 1e-48
gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4 is... 190 2e-48
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 189 3e-48
gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4 iso... 187 2e-47
gi|9966875 calcium/calmodulin-dependent protein kinase ID isofor... 186 4e-47
gi|23943850 calcium/calmodulin-dependent protein kinase ID isofo... 186 4e-47
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 186 4e-47
gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo ... 184 9e-47
gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a... 183 2e-46
gi|207113186 MAP kinase-interacting serine/threonine kinase 1 is... 181 1e-45
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 177 1e-44
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 177 1e-44
gi|39752689 MAP kinase-interacting serine/threonine kinase 1 iso... 175 7e-44
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 174 9e-44
gi|40018631 MAP kinase-interacting serine/threonine kinase 2 iso... 174 2e-43
gi|40018627 MAP kinase-interacting serine/threonine kinase 2 iso... 172 3e-43
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 170 2e-42
gi|54112407 protein kinase CHK2 isoform c [Homo sapiens] 169 3e-42
gi|6005850 protein kinase CHK2 isoform a [Homo sapiens] 169 3e-42
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 168 7e-42
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 167 2e-41
gi|27901803 protein serine kinase H1 [Homo sapiens] 165 6e-41
>gi|4758700 mitogen-activated protein kinase-activated protein
kinase 3 [Homo sapiens]
Length = 382
Score = 793 bits (2048), Expect = 0.0
Identities = 382/382 (100%), Positives = 382/382 (100%)
Query: 1 MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE 60
MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE
Sbjct: 1 MDGETAEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLE 60
Query: 61 CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC 120
CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC
Sbjct: 61 CFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMEC 120
Query: 121 MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD 180
MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD
Sbjct: 121 MEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKD 180
Query: 181 AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP 240
AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP
Sbjct: 181 AVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFP 240
Query: 241 PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN 300
PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN
Sbjct: 241 PFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMN 300
Query: 301 HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR 360
HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR
Sbjct: 301 HPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNR 360
Query: 361 LLNKRRKKQAGSSSASQGCNNQ 382
LLNKRRKKQAGSSSASQGCNNQ
Sbjct: 361 LLNKRRKKQAGSSSASQGCNNQ 382
>gi|32481209 mitogen-activated protein kinase-activated protein
kinase 2 isoform 2 [Homo sapiens]
Length = 400
Score = 535 bits (1377), Expect = e-152
Identities = 265/393 (67%), Positives = 315/393 (80%), Gaps = 22/393 (5%)
Query: 6 AEEQGGPVP-----PPVAPGGPGLGGAPGGRREP----------------KKYAVTDDYQ 44
++ Q PVP PP P P L P P KK A+ DDY+
Sbjct: 5 SQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYK 64
Query: 45 LSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVY 104
++ QVLGLG+NGKVL+ F++RT +K ALK+L D PKAR+EV+ HW+AS PHIV I+DVY
Sbjct: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVY 124
Query: 105 ENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAH 164
EN++ G++CLLI+MEC++GGELFSRIQ+RGDQAFTEREA+EIM+ IG AIQ+LHS NIAH
Sbjct: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184
Query: 165 RDVKPENLLYTSKEKDAVLKLTDFGFAKETTQ-NALQTPCYTPYYVAPEVLGPEKYDKSC 223
RDVKPENLLYTSK +A+LKLTDFGFAKETT N+L TPCYTPYYVAPEVLGPEKYDKSC
Sbjct: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSC 244
Query: 224 DMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRL 283
DMWSLGVIMYILLCG+PPFYSN G AISPGMK RIR+GQY FPNPEWSEVSE+ K LIR
Sbjct: 245 DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRN 304
Query: 284 LLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMR 343
LLKT+PT+R+TIT+FMNHPWI QS VPQTPLHT+RVL+EDK+ W++VKEEMTSALATMR
Sbjct: 305 LLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMR 364
Query: 344 VDYDQVKIKDLKTSNNRLLNKRRKKQAGSSSAS 376
VDY+Q+KIK ++ ++N LL KRRKK +A+
Sbjct: 365 VDYEQIKIKKIEDASNPLLLKRRKKARALEAAA 397
>gi|10863901 mitogen-activated protein kinase-activated protein
kinase 2 isoform 1 [Homo sapiens]
Length = 370
Score = 484 bits (1246), Expect = e-137
Identities = 238/349 (68%), Positives = 280/349 (80%), Gaps = 22/349 (6%)
Query: 6 AEEQGGPVP-----PPVAPGGPGLGGAPGGRREP----------------KKYAVTDDYQ 44
++ Q PVP PP P P L P P KK A+ DDY+
Sbjct: 5 SQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYK 64
Query: 45 LSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVY 104
++ QVLGLG+NGKVL+ F++RT +K ALK+L D PKAR+EV+ HW+AS PHIV I+DVY
Sbjct: 65 VTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVY 124
Query: 105 ENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAH 164
EN++ G++CLLI+MEC++GGELFSRIQ+RGDQAFTEREA+EIM+ IG AIQ+LHS NIAH
Sbjct: 125 ENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAH 184
Query: 165 RDVKPENLLYTSKEKDAVLKLTDFGFAKETTQ-NALQTPCYTPYYVAPEVLGPEKYDKSC 223
RDVKPENLLYTSK +A+LKLTDFGFAKETT N+L TPCYTPYYVAPEVLGPEKYDKSC
Sbjct: 185 RDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSC 244
Query: 224 DMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRL 283
DMWSLGVIMYILLCG+PPFYSN G AISPGMK RIR+GQY FPNPEWSEVSE+ K LIR
Sbjct: 245 DMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRN 304
Query: 284 LLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWDEVK 332
LLKT+PT+R+TIT+FMNHPWI QS VPQTPLHT+RVL+EDK+ W++VK
Sbjct: 305 LLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVK 353
>gi|21237768 MAP kinase-activated protein kinase 5 isoform 2 [Homo
sapiens]
Length = 473
Score = 263 bits (673), Expect = 1e-70
Identities = 150/358 (41%), Positives = 218/358 (60%), Gaps = 31/358 (8%)
Query: 35 KKYAVTDDYQLS-KQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASG 93
K+ ++ ++Y ++ Q LG G++G V C + T ++ ALK+L D PKAR EV H +
Sbjct: 12 KETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCAT 71
Query: 94 GPHIVCILDVYENM----HHG--KRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIM 147
P+IV I++V+ N H + LLI+ME MEGGELF RI + + FTE++A+++
Sbjct: 72 HPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQH--RHFTEKQASQVT 129
Query: 148 RDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPY 207
+ I A++ H NIAHRD+KPENLL+ DA +KL DFGFAK Q L TP +TPY
Sbjct: 130 KQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK-IDQGDLMTPQFTPY 188
Query: 208 YVAPEVLG------------------PEKYDKSCDMWSLGVIMYILLCGFPPFYS-NTGQ 248
YVAP+VL P Y+KSCD+WSLGVI+Y++LCG+PPFYS + +
Sbjct: 189 YVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSR 248
Query: 249 AISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSM 308
I M+R+I G + FP EWS++SE AK ++R LLK P ERLTI ++HPW+N +
Sbjct: 249 TIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTE 308
Query: 309 VVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRR 366
+ L +A+++ DK +++ LA MR+ +V +K L + NN +L KR+
Sbjct: 309 ALDNV-LPSAQLMM-DKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK 364
>gi|21237765 MAP kinase-activated protein kinase 5 isoform 1 [Homo
sapiens]
Length = 471
Score = 263 bits (673), Expect = 1e-70
Identities = 150/358 (41%), Positives = 218/358 (60%), Gaps = 31/358 (8%)
Query: 35 KKYAVTDDYQLS-KQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASG 93
K+ ++ ++Y ++ Q LG G++G V C + T ++ ALK+L D PKAR EV H +
Sbjct: 12 KETSILEEYSINWTQKLGAGISGPVRVCVKKSTQERFALKILLDRPKARNEVRLHMMCAT 71
Query: 94 GPHIVCILDVYENM----HHG--KRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIM 147
P+IV I++V+ N H + LLI+ME MEGGELF RI + + FTE++A+++
Sbjct: 72 HPNIVQIIEVFANSVQFPHESSPRARLLIVMEMMEGGELFHRISQH--RHFTEKQASQVT 129
Query: 148 RDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPY 207
+ I A++ H NIAHRD+KPENLL+ DA +KL DFGFAK Q L TP +TPY
Sbjct: 130 KQIALALRHCHLLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK-IDQGDLMTPQFTPY 188
Query: 208 YVAPEVLG------------------PEKYDKSCDMWSLGVIMYILLCGFPPFYS-NTGQ 248
YVAP+VL P Y+KSCD+WSLGVI+Y++LCG+PPFYS + +
Sbjct: 189 YVAPQVLEAQRRHQKEKSGIIPTSPTPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSR 248
Query: 249 AISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSM 308
I M+R+I G + FP EWS++SE AK ++R LLK P ERLTI ++HPW+N +
Sbjct: 249 TIPKDMRRKIMTGSFEFPEEEWSQISEMAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTE 308
Query: 309 VVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRR 366
+ L +A+++ DK +++ LA MR+ +V +K L + NN +L KR+
Sbjct: 309 ALDNV-LPSAQLMM-DKAVVAGIQQAHAEQLANMRIQDLKVSLKPLHSVNNPILRKRK 364
>gi|14196445 calcium/calmodulin-dependent protein kinase IG [Homo
sapiens]
Length = 476
Score = 199 bits (506), Expect = 3e-51
Identities = 107/269 (39%), Positives = 159/269 (59%), Gaps = 28/269 (10%)
Query: 48 QVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKAR-----------QEVDHHWQASGGPH 96
+VLG G +V R TG+ ALK + SP R +++ H +
Sbjct: 27 EVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHE-------N 79
Query: 97 IVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQF 156
IV + D+YE+ H ++M+ + GGELF RI ERG +TE++A+ +++ + +A+++
Sbjct: 80 IVTLEDIYESTTH----YYLVMQLVSGGELFDRILERG--VYTEKDASLVIQQVLSAVKY 133
Query: 157 LHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGP 216
LH + I HRD+KPENLLY + E+++ + +TDFG +K + T C TP YVAPEVL
Sbjct: 134 LHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQ 193
Query: 217 EKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSED 276
+ Y K+ D WS+GVI YILLCG+PPFY T + +I+ G Y F +P W ++SE
Sbjct: 194 KPYSKAVDCWSIGVITYILLCGYPPFYEETESKLF----EKIKEGYYEFESPFWDDISES 249
Query: 277 AKQLIRLLLKTDPTERLTITQFMNHPWIN 305
AK I LL+ DP ER T + ++HPWI+
Sbjct: 250 AKDFICHLLEKDPNERYTCEKALSHPWID 278
>gi|4502553 calcium/calmodulin-dependent protein kinase I [Homo
sapiens]
Length = 370
Score = 191 bits (486), Expect = 7e-49
Identities = 110/285 (38%), Positives = 163/285 (57%), Gaps = 17/285 (5%)
Query: 26 GAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEV 85
GA G R + + D Y + VLG G +V+ +RT + A+K + +E
Sbjct: 3 GAVEGPRWKQAEDIRDIYDF-RDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEG 61
Query: 86 DHHWQAS-----GGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTE 140
+ + P+IV + D+YE+ H L +IM+ + GGELF RI E+G +TE
Sbjct: 62 SMENEIAVLHKIKHPNIVALDDIYESGGH----LYLIMQLVSGGELFDRIVEKG--FYTE 115
Query: 141 REAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-ETTQNAL 199
R+A+ ++ + A+++LH I HRD+KPENLLY S ++D+ + ++DFG +K E + L
Sbjct: 116 RDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVL 175
Query: 200 QTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIR 259
T C TP YVAPEVL + Y K+ D WS+GVI YILLCG+PPFY + +I
Sbjct: 176 STACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLF----EQIL 231
Query: 260 LGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWI 304
+Y F +P W ++S+ AK IR L++ DP +R T Q + HPWI
Sbjct: 232 KAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform b [Homo sapiens]
Length = 744
Score = 191 bits (484), Expect = 1e-48
Identities = 112/345 (32%), Positives = 188/345 (54%), Gaps = 26/345 (7%)
Query: 36 KYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPK-ARQEVDHHWQASGG 94
K V D + K+ +G+G + C H+ T + A+K++ S + +E++ +
Sbjct: 419 KNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQH 478
Query: 95 PHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAI 154
P+I+ + DVY++ H + ++ E M GGEL +I + + F+EREA+ ++ IG +
Sbjct: 479 PNIITLKDVYDDGKH----VYLVTELMRGGELLDKILRQ--KFFSEREASFVLHTIGKTV 532
Query: 155 QFLHSHNIAHRDVKPENLLYTSKEKDA-VLKLTDFGFAKE--TTQNALQTPCYTPYYVAP 211
++LHS + HRD+KP N+LY + + L++ DFGFAK+ L TPCYT +VAP
Sbjct: 533 EYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAP 592
Query: 212 EVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWS 271
EVL + YD+ CD+WSLG+++Y +L G+ PF +N + RI G++ W+
Sbjct: 593 EVLKRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWN 651
Query: 272 EVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWD-- 329
VSE AK L+ +L DP +RLT Q + HPW+ Q +PQ+ L H D
Sbjct: 652 TVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQL----------SHQDLQ 701
Query: 330 EVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSS 374
VK M + + + ++K +++S +L +RR ++ S++
Sbjct: 702 LVKGAMAATYSALNSSKPTPQLKPIESS---ILAQRRVRKLPSTT 743
Score = 97.4 bits (241), Expect = 2e-20
Identities = 58/183 (31%), Positives = 103/183 (56%), Gaps = 17/183 (9%)
Query: 114 LLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLL 173
L +I++ + GG+LF+R+ + + FTE + + ++ + LHS I +RD+KPEN+L
Sbjct: 146 LYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENIL 203
Query: 174 YTSKEKDAVLKLTDFGFAKETTQNALQTP--CYTPYYVAPEVLGPEKYDKSCDMWSLGVI 231
+++ +KLTDFG +KE + + C T Y+APEV+ + + S D WS GV+
Sbjct: 204 L---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVL 260
Query: 232 MYILLCGFPPFY-SNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPT 290
M+ +L G PF + + ++ +K ++ + Q+ +S +A+ L+R L K +P
Sbjct: 261 MFEMLTGSLPFQGKDRKETMTLILKAKLGMPQF---------LSTEAQSLLRALFKRNPA 311
Query: 291 ERL 293
RL
Sbjct: 312 NRL 314
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1
isoform a [Homo sapiens]
Length = 735
Score = 191 bits (484), Expect = 1e-48
Identities = 112/345 (32%), Positives = 188/345 (54%), Gaps = 26/345 (7%)
Query: 36 KYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPK-ARQEVDHHWQASGG 94
K V D + K+ +G+G + C H+ T + A+K++ S + +E++ +
Sbjct: 410 KNLVFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSEEIEILLRYGQH 469
Query: 95 PHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAI 154
P+I+ + DVY++ H + ++ E M GGEL +I + + F+EREA+ ++ IG +
Sbjct: 470 PNIITLKDVYDDGKH----VYLVTELMRGGELLDKILRQ--KFFSEREASFVLHTIGKTV 523
Query: 155 QFLHSHNIAHRDVKPENLLYTSKEKDA-VLKLTDFGFAKE--TTQNALQTPCYTPYYVAP 211
++LHS + HRD+KP N+LY + + L++ DFGFAK+ L TPCYT +VAP
Sbjct: 524 EYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAP 583
Query: 212 EVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWS 271
EVL + YD+ CD+WSLG+++Y +L G+ PF +N + RI G++ W+
Sbjct: 584 EVLKRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGSGKFTLSGGNWN 642
Query: 272 EVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWD-- 329
VSE AK L+ +L DP +RLT Q + HPW+ Q +PQ+ L H D
Sbjct: 643 TVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQSQL----------SHQDLQ 692
Query: 330 EVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRKKQAGSSS 374
VK M + + + ++K +++S +L +RR ++ S++
Sbjct: 693 LVKGAMAATYSALNSSKPTPQLKPIESS---ILAQRRVRKLPSTT 734
Score = 97.4 bits (241), Expect = 2e-20
Identities = 58/183 (31%), Positives = 103/183 (56%), Gaps = 17/183 (9%)
Query: 114 LLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLL 173
L +I++ + GG+LF+R+ + + FTE + + ++ + LHS I +RD+KPEN+L
Sbjct: 137 LYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENIL 194
Query: 174 YTSKEKDAVLKLTDFGFAKETTQNALQTP--CYTPYYVAPEVLGPEKYDKSCDMWSLGVI 231
+++ +KLTDFG +KE + + C T Y+APEV+ + + S D WS GV+
Sbjct: 195 L---DEEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAPEVVNRQGHSHSADWWSYGVL 251
Query: 232 MYILLCGFPPFY-SNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPT 290
M+ +L G PF + + ++ +K ++ + Q+ +S +A+ L+R L K +P
Sbjct: 252 MFEMLTGSLPFQGKDRKETMTLILKAKLGMPQF---------LSTEAQSLLRALFKRNPA 302
Query: 291 ERL 293
RL
Sbjct: 303 NRL 305
>gi|55743138 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform b [Homo sapiens]
Length = 766
Score = 190 bits (482), Expect = 2e-48
Identities = 124/369 (33%), Positives = 199/369 (53%), Gaps = 27/369 (7%)
Query: 22 PGLGGAPGGRREPKKYAVTDDYQLS--KQVLGLGVNGKVLECFHRRTGQKCALKLLYDSP 79
PG G PG R + A+ Y+L + LG G C R++GQ+ A+K+L
Sbjct: 382 PGAGDRPG-RAAVARSAMMQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKILSRRL 440
Query: 80 KA--RQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQA 137
+A ++EV P++V + +V HH + +++E + GGEL I+++ +
Sbjct: 441 EANTQREVAALRLCQSHPNVVNLHEV----HHDQLHTYLVLELLRGGELLEHIRKK--RH 494
Query: 138 FTEREAAEIMRDIGTAIQFLHSH-NIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQ 196
F+E EA++I+R + +A+ F+H + HRD+KPEN+LY A +K+ DFGFA+ Q
Sbjct: 495 FSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFARLRPQ 554
Query: 197 NA---LQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNT---GQAI 250
+ +QTPC+T Y APE+L + YD+SCD+WSLGVI+Y++L G PF + GQ+
Sbjct: 555 SPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQ 614
Query: 251 SPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVV 310
+ + +IR G++ W VSE+AK+L+R LL DP +RL + W+
Sbjct: 615 AAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSAR 674
Query: 311 PQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKD--LKTSNNRLLNKRRKK 368
PL T VL+ + S L + +++ K + LK+ N L KRRK+
Sbjct: 675 SSPPLRTPDVLESS-------GPAVRSGLNATFMAFNRGKREGFFLKSVENAPLAKRRKQ 727
Query: 369 QAGSSSASQ 377
+ S++AS+
Sbjct: 728 KLRSATASR 736
Score = 85.5 bits (210), Expect = 7e-17
Identities = 82/280 (29%), Positives = 134/280 (47%), Gaps = 27/280 (9%)
Query: 41 DDYQLSKQVLGLGVNGKVL---ECFHRRTGQKCALKLLYDSPKA-RQEVDHHWQASGGP- 95
++++L K VLG G GKV + G+ A+K+L + R + H +
Sbjct: 31 ENFELLK-VLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVL 89
Query: 96 HIVCILDVYENMHHGKRC---LLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGT 152
+V +H+ + L +I++ + GGE+F+ + +R Q F E E +I
Sbjct: 90 ELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQR--QYFKEAEVRVYGGEIVL 147
Query: 153 AIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTP---CYTPYYV 209
A++ LH I +RD+K EN+L S + + LTDFG +KE + C T Y+
Sbjct: 148 ALEHLHKLGIIYRDLKLENVLLDS---EGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYM 204
Query: 210 APEVLGPEK-YDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNP 268
APE++ + + K+ D WSLG++++ LL G PF + + RRI FP P
Sbjct: 205 APEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFP-P 263
Query: 269 EWSEVSEDAKQLIRLLLKTDPTERL-----TITQFMNHPW 303
V++D L++ LL DP +RL + NHP+
Sbjct: 264 RIGPVAQD---LLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 189 bits (481), Expect = 3e-48
Identities = 117/315 (37%), Positives = 168/315 (53%), Gaps = 30/315 (9%)
Query: 11 GPVPPPVAPGGPGLGGAPGGRREPKKY---AVTDDYQLSKQV------------LGLGVN 55
GP P + G GG R P + A+ D L K LG G
Sbjct: 50 GPAGPQLREAARASSGLGGGGRHPSRIPAIALQDMLLLKKHTEDISSVYEIRERLGSGAF 109
Query: 56 GKVLECFHRRTGQKCALKLLYDSPKARQE--VDHH---WQASGGPHIVCILDVYENMHHG 110
+V+ R + ALK + +E V++ + P+IV + DV+E+ H
Sbjct: 110 SEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSH- 168
Query: 111 KRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPE 170
L + ME + GGELF RI ERG ++TE++A+ ++ + A+ +LHS I HRD+KPE
Sbjct: 169 ---LYLAMELVTGGELFDRIMERG--SYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPE 223
Query: 171 NLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 230
NLLY + +D+ + ++DFG +K N L T C TP YVAPE+L + Y K+ D+W+LGV
Sbjct: 224 NLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGV 283
Query: 231 IMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPT 290
I YILLCG+PPFY + P + +I Y F +P W ++SE AK IR LL+ DP
Sbjct: 284 ISYILLCGYPPFYDES----DPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQ 339
Query: 291 ERLTITQFMNHPWIN 305
+R T Q + H WI+
Sbjct: 340 KRFTCQQALRHLWIS 354
>gi|4506735 ribosomal protein S6 kinase, 90kDa, polypeptide 4
isoform a [Homo sapiens]
Length = 772
Score = 187 bits (474), Expect = 2e-47
Identities = 122/374 (32%), Positives = 197/374 (52%), Gaps = 31/374 (8%)
Query: 22 PGLGGAPGGRREPKKYAVTD-------DYQLSKQVLGLGVNGKVLECFHRRTGQKCALKL 74
PG G PG + + D + L + LG G C R++GQ+ A+K+
Sbjct: 382 PGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPALGQGSFSVCRRCRQRQSGQEFAVKI 441
Query: 75 LYDSPKA--RQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQE 132
L +A ++EV P++V + +V HH + +++E + GGEL I++
Sbjct: 442 LSRRLEANTQREVAALRLCQSHPNVVNLHEV----HHDQLHTYLVLELLRGGELLEHIRK 497
Query: 133 RGDQAFTEREAAEIMRDIGTAIQFLHSH-NIAHRDVKPENLLYTSKEKDAVLKLTDFGFA 191
+ + F+E EA++I+R + +A+ F+H + HRD+KPEN+LY A +K+ DFGFA
Sbjct: 498 K--RHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYADDTPGAPVKIIDFGFA 555
Query: 192 KETTQNA---LQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNT-- 246
+ Q+ +QTPC+T Y APE+L + YD+SCD+WSLGVI+Y++L G PF +
Sbjct: 556 RLRPQSPGVPMQTPCFTLQYAAPELLAQQGYDESCDLWSLGVILYMMLSGQVPFQGASGQ 615
Query: 247 -GQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWIN 305
GQ+ + + +IR G++ W VSE+AK+L+R LL DP +RL + W+
Sbjct: 616 GGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQ 675
Query: 306 QSMVVPQTPLHTARVLQEDKDHWDEVKEEMTSALATMRVDYDQVKIKD--LKTSNNRLLN 363
PL T VL+ + S L + +++ K + LK+ N L
Sbjct: 676 DGSARSSPPLRTPDVLESS-------GPAVRSGLNATFMAFNRGKREGFFLKSVENAPLA 728
Query: 364 KRRKKQAGSSSASQ 377
KRRK++ S++AS+
Sbjct: 729 KRRKQKLRSATASR 742
Score = 85.5 bits (210), Expect = 7e-17
Identities = 82/280 (29%), Positives = 134/280 (47%), Gaps = 27/280 (9%)
Query: 41 DDYQLSKQVLGLGVNGKVL---ECFHRRTGQKCALKLLYDSPKA-RQEVDHHWQASGGP- 95
++++L K VLG G GKV + G+ A+K+L + R + H +
Sbjct: 31 ENFELLK-VLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVL 89
Query: 96 HIVCILDVYENMHHGKRC---LLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGT 152
+V +H+ + L +I++ + GGE+F+ + +R Q F E E +I
Sbjct: 90 ELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQR--QYFKEAEVRVYGGEIVL 147
Query: 153 AIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTP---CYTPYYV 209
A++ LH I +RD+K EN+L S + + LTDFG +KE + C T Y+
Sbjct: 148 ALEHLHKLGIIYRDLKLENVLLDS---EGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYM 204
Query: 210 APEVLGPEK-YDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNP 268
APE++ + + K+ D WSLG++++ LL G PF + + RRI FP P
Sbjct: 205 APEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFP-P 263
Query: 269 EWSEVSEDAKQLIRLLLKTDPTERL-----TITQFMNHPW 303
V++D L++ LL DP +RL + NHP+
Sbjct: 264 RIGPVAQD---LLQRLLCKDPKKRLGAGPQGAQEVRNHPF 300
>gi|9966875 calcium/calmodulin-dependent protein kinase ID isoform 1
[Homo sapiens]
Length = 357
Score = 186 bits (471), Expect = 4e-47
Identities = 100/264 (37%), Positives = 155/264 (58%), Gaps = 16/264 (6%)
Query: 47 KQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQAS-----GGPHIVCIL 101
K+ LG G +V+ + TG+ A+K + +E + + +IV +
Sbjct: 26 KETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALE 85
Query: 102 DVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHN 161
D+YE+ +H L ++M+ + GGELF RI E+G +TE++A+ ++R + A+ +LH
Sbjct: 86 DIYESPNH----LYLVMQLVSGGELFDRIVEKG--FYTEKDASTLIRQVLDAVYYLHRMG 139
Query: 162 IAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-ETTQNALQTPCYTPYYVAPEVLGPEKYD 220
I HRD+KPENLLY S+++++ + ++DFG +K E + + T C TP YVAPEVL + Y
Sbjct: 140 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYS 199
Query: 221 KSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQL 280
K+ D WS+GVI YILLCG+PPFY + +I +Y F +P W ++S+ AK
Sbjct: 200 KAVDCWSIGVIAYILLCGYPPFYDENDSKLF----EQILKAEYEFDSPYWDDISDSAKDF 255
Query: 281 IRLLLKTDPTERLTITQFMNHPWI 304
IR L++ DP +R T Q HPWI
Sbjct: 256 IRNLMEKDPNKRYTCEQAARHPWI 279
>gi|23943850 calcium/calmodulin-dependent protein kinase ID isoform
2 [Homo sapiens]
Length = 385
Score = 186 bits (471), Expect = 4e-47
Identities = 100/264 (37%), Positives = 155/264 (58%), Gaps = 16/264 (6%)
Query: 47 KQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQAS-----GGPHIVCIL 101
K+ LG G +V+ + TG+ A+K + +E + + +IV +
Sbjct: 26 KETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALE 85
Query: 102 DVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHN 161
D+YE+ +H L ++M+ + GGELF RI E+G +TE++A+ ++R + A+ +LH
Sbjct: 86 DIYESPNH----LYLVMQLVSGGELFDRIVEKG--FYTEKDASTLIRQVLDAVYYLHRMG 139
Query: 162 IAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-ETTQNALQTPCYTPYYVAPEVLGPEKYD 220
I HRD+KPENLLY S+++++ + ++DFG +K E + + T C TP YVAPEVL + Y
Sbjct: 140 IVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYS 199
Query: 221 KSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQL 280
K+ D WS+GVI YILLCG+PPFY + +I +Y F +P W ++S+ AK
Sbjct: 200 KAVDCWSIGVIAYILLCGYPPFYDENDSKLF----EQILKAEYEFDSPYWDDISDSAKDF 255
Query: 281 IRLLLKTDPTERLTITQFMNHPWI 304
IR L++ DP +R T Q HPWI
Sbjct: 256 IRNLMEKDPNKRYTCEQAARHPWI 279
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 186 bits (471), Expect = 4e-47
Identities = 95/211 (45%), Positives = 135/211 (63%), Gaps = 10/211 (4%)
Query: 95 PHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAI 154
P+IV + DV+E+ H L + ME + GGELF RI ERG ++TE++A+ ++ + A+
Sbjct: 88 PNIVALEDVHESPSH----LYLAMELVTGGELFDRIMERG--SYTEKDASHLVGQVLGAV 141
Query: 155 QFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYVAPEVL 214
+LHS I HRD+KPENLLY + +D+ + ++DFG +K N L T C TP YVAPE+L
Sbjct: 142 SYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELL 201
Query: 215 GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVS 274
+ Y K+ D+W+LGVI YILLCG+PPFY + P + +I Y F +P W ++S
Sbjct: 202 EQKPYGKAVDVWALGVISYILLCGYPPFYDES----DPELFSQILRASYEFDSPFWDDIS 257
Query: 275 EDAKQLIRLLLKTDPTERLTITQFMNHPWIN 305
E AK IR LL+ DP +R T Q + H WI+
Sbjct: 258 ESAKDFIRHLLERDPQKRFTCQQALRHLWIS 288
>gi|4502557 calcium/calmodulin-dependent protein kinase IV [Homo
sapiens]
Length = 473
Score = 184 bits (468), Expect = 9e-47
Identities = 109/271 (40%), Positives = 157/271 (57%), Gaps = 15/271 (5%)
Query: 38 AVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL---YDSPKARQEVDHHWQASGG 94
A++D +++ + LG G V C + T + ALK+L D R E+ + S
Sbjct: 41 ALSDFFEVESE-LGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSH- 98
Query: 95 PHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAI 154
P+I+ + +++E + +++E + GGELF RI E+G ++ER+AA+ ++ I A+
Sbjct: 99 PNIIKLKEIFETPTE----ISLVLELVTGGELFDRIVEKG--YYSERDAADAVKQILEAV 152
Query: 155 QFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNAL-QTPCYTPYYVAPEV 213
+LH + I HRD+KPENLLY + DA LK+ DFG +K L +T C TP Y APE+
Sbjct: 153 AYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEI 212
Query: 214 LGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEV 273
L Y DMWS+G+I YILLCGF PFY G M RRI +Y F +P W EV
Sbjct: 213 LRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQF---MFRRILNCEYYFISPWWDEV 269
Query: 274 SEDAKQLIRLLLKTDPTERLTITQFMNHPWI 304
S +AK L+R L+ DP +RLT Q + HPW+
Sbjct: 270 SLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 300
>gi|32528295 ribosomal protein S6 kinase, polypeptide 5 isoform a
[Homo sapiens]
Length = 802
Score = 183 bits (465), Expect = 2e-46
Identities = 101/287 (35%), Positives = 162/287 (56%), Gaps = 13/287 (4%)
Query: 42 DYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKA--RQEVDHHWQASGGPHIVC 99
D L + LG G +C H+++ Q A+K++ +A ++E+ G P+IV
Sbjct: 424 DLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCEGHPNIVK 483
Query: 100 ILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHS 159
+ +V+ + H ++ME + GGELF RI+++ + F+E EA+ IMR + +A+ +H
Sbjct: 484 LHEVFHDQLH----TFLVMELLNGGELFERIKKK--KHFSETEASYIMRKLVSAVSHMHD 537
Query: 160 HNIAHRDVKPENLLYTSKEKDAVLKLTDFGFA--KETTQNALQTPCYTPYYVAPEVLGPE 217
+ HRD+KPENLL+T + + +K+ DFGFA K L+TPC+T +Y APE+L
Sbjct: 538 VGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELLNQN 597
Query: 218 KYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPG---MKRRIRLGQYGFPNPEWSEVS 274
YD+SCD+WSLGVI+Y +L G PF S+ + ++I+ G + F W VS
Sbjct: 598 GYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVS 657
Query: 275 EDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVL 321
++AK LI+ LL DP +RL ++ + W+ + PL T +L
Sbjct: 658 QEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDIL 704
Score = 105 bits (262), Expect = 7e-23
Identities = 88/273 (32%), Positives = 140/273 (51%), Gaps = 37/273 (13%)
Query: 41 DDYQLSKQVLGLGVNGKVL---ECFHRRTGQKCALKLLYDSP------------KARQEV 85
++++L K VLG G GKV + TG+ A+K+L + RQ +
Sbjct: 47 ENFELLK-VLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVL 105
Query: 86 DHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAE 145
+H Q+ P +V + ++ + L +I++ + GGELF+ + +R + FTE E
Sbjct: 106 EHIRQS---PFLVTLHYAFQT----ETKLHLILDYINGGELFTHLSQR--ERFTEHEVQI 156
Query: 146 IMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTP--- 202
+ +I A++ LH I +RD+K EN+L S + + LTDFG +KE + +
Sbjct: 157 YVGEIVLALEHLHKLGIIYRDIKLENILLDS---NGHVVLTDFGLSKEFVADETERAYSF 213
Query: 203 CYTPYYVAPEVL--GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRL 260
C T Y+AP+++ G +DK+ D WSLGV+MY LL G PF + + + RRI
Sbjct: 214 CGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILK 273
Query: 261 GQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERL 293
+ +P E+S AK LI+ LL DP +RL
Sbjct: 274 SEPPYP----QEMSALAKDLIQRLLMKDPKKRL 302
>gi|207113186 MAP kinase-interacting serine/threonine kinase 1
isoform 3 [Homo sapiens]
Length = 424
Score = 181 bits (458), Expect = 1e-45
Identities = 114/355 (32%), Positives = 183/355 (51%), Gaps = 43/355 (12%)
Query: 8 EQGGPVPPPVAPGGPGLGGAPGGRRE---PKKYAVTDDYQLSKQVLGLGVNGKVLECFHR 64
E G P P+A G GR P K+ D Y+L+ ++LG G KV
Sbjct: 12 EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFE--DMYKLTSELLGEGAYAKVQGAVSL 69
Query: 65 RTGQKCALKLL-----YDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIME 119
+ G++ A+K++ + + +EV+ +Q G +I+ +++ +E+ ++ E
Sbjct: 70 QNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTR----FYLVFE 125
Query: 120 CMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEK 179
++GG + + IQ++ + F EREA+ ++RD+ A+ FLH+ IAHRD+KPEN+L S EK
Sbjct: 126 KLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEK 183
Query: 180 DAVLKLTDFGFAK---------ETTQNALQTPCYTPYYVAPEVL-----GPEKYDKSCDM 225
+ +K+ DF T L TPC + Y+APEV+ YDK CD+
Sbjct: 184 VSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDL 243
Query: 226 WSLGVIMYILLCGFPPFYSNTG-----------QAISPGMKRRIRLGQYGFPNPEWSEVS 274
WSLGV++YI+L G+PPF + G + + I+ G+Y FP+ +W+ +S
Sbjct: 244 WSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHIS 303
Query: 275 EDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLHTARVLQEDKDHWD 329
+AK LI LL D +RL+ Q + HPW+ P+ L T +VLQ + D
Sbjct: 304 SEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQ--APEKGLPTPQVLQRNSSTMD 356
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform b [Homo sapiens]
Length = 741
Score = 177 bits (450), Expect = 1e-44
Identities = 95/269 (35%), Positives = 155/269 (57%), Gaps = 12/269 (4%)
Query: 40 TDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPK-ARQEVDHHWQASGGPHIV 98
TD Y++ K+ +G+G C H+ T + A+K++ S + +E++ + P+I+
Sbjct: 420 TDGYEI-KEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNII 478
Query: 99 CILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLH 158
+ DVY++ + + ++ME M GGEL RI + + F+EREA++++ I + +LH
Sbjct: 479 TLKDVYDD----GKFVYLVMELMRGGELLDRILRQ--RYFSEREASDVLCTITKTMDYLH 532
Query: 159 SHNIAHRDVKPENLLYTSKE-KDAVLKLTDFGFAKETT--QNALQTPCYTPYYVAPEVLG 215
S + HRD+KP N+LY + +++ DFGFAK+ L TPCYT +VAPEVL
Sbjct: 533 SQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLK 592
Query: 216 PEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSE 275
+ YD +CD+WSLG+++Y +L GF PF +N + RI G+Y W +S+
Sbjct: 593 RQGYDAACDIWSLGILLYTMLAGFTPF-ANGPDDTPEEILARIGSGKYALSGGNWDSISD 651
Query: 276 DAKQLIRLLLKTDPTERLTITQFMNHPWI 304
AK ++ +L DP +RLT Q + HPW+
Sbjct: 652 AAKDVVSKMLHVDPHQRLTAMQVLKHPWV 680
Score = 99.0 bits (245), Expect = 6e-21
Identities = 80/273 (29%), Positives = 138/273 (50%), Gaps = 35/273 (12%)
Query: 48 QVLGLGVNGKVL---ECFHRRTGQKCALKLLYDSP-KARQEVDHHWQAS-----GGPHIV 98
+VLG G GKV + GQ A+K+L + K R V + P IV
Sbjct: 71 KVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIV 130
Query: 99 CILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLH 158
+ ++ GK L +I++ + GG+LF+R+ + + FTE + + ++ A+ LH
Sbjct: 131 KLHYAFQT--EGK--LYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALALDHLH 184
Query: 159 SHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTP--CYTPYYVAPEVLGP 216
S I +RD+KPEN+L +++ +K+TDFG +KE + + C T Y+APEV+
Sbjct: 185 SLGIIYRDLKPENILL---DEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNR 241
Query: 217 EKYDKSCDMWSLGVIMYILLCGFPPFY-SNTGQAISPGMKRRIRLGQYGFPNPEWSEVSE 275
+ +S D WS GV+M+ +L G PF + + ++ +K ++ + Q+ +S
Sbjct: 242 RGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQF---------LSG 292
Query: 276 DAKQLIRLLLKTDPTERL-----TITQFMNHPW 303
+A+ L+R L K +P RL + + HP+
Sbjct: 293 EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPF 325
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2
isoform a [Homo sapiens]
Length = 733
Score = 177 bits (450), Expect = 1e-44
Identities = 95/269 (35%), Positives = 155/269 (57%), Gaps = 12/269 (4%)
Query: 40 TDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPK-ARQEVDHHWQASGGPHIV 98
TD Y++ K+ +G+G C H+ T + A+K++ S + +E++ + P+I+
Sbjct: 412 TDGYEI-KEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNII 470
Query: 99 CILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLH 158
+ DVY++ + + ++ME M GGEL RI + + F+EREA++++ I + +LH
Sbjct: 471 TLKDVYDD----GKFVYLVMELMRGGELLDRILRQ--RYFSEREASDVLCTITKTMDYLH 524
Query: 159 SHNIAHRDVKPENLLYTSKE-KDAVLKLTDFGFAKETT--QNALQTPCYTPYYVAPEVLG 215
S + HRD+KP N+LY + +++ DFGFAK+ L TPCYT +VAPEVL
Sbjct: 525 SQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLK 584
Query: 216 PEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSE 275
+ YD +CD+WSLG+++Y +L GF PF +N + RI G+Y W +S+
Sbjct: 585 RQGYDAACDIWSLGILLYTMLAGFTPF-ANGPDDTPEEILARIGSGKYALSGGNWDSISD 643
Query: 276 DAKQLIRLLLKTDPTERLTITQFMNHPWI 304
AK ++ +L DP +RLT Q + HPW+
Sbjct: 644 AAKDVVSKMLHVDPHQRLTAMQVLKHPWV 672
Score = 99.0 bits (245), Expect = 6e-21
Identities = 80/273 (29%), Positives = 138/273 (50%), Gaps = 35/273 (12%)
Query: 48 QVLGLGVNGKVL---ECFHRRTGQKCALKLLYDSP-KARQEVDHHWQAS-----GGPHIV 98
+VLG G GKV + GQ A+K+L + K R V + P IV
Sbjct: 63 KVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIV 122
Query: 99 CILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLH 158
+ ++ GK L +I++ + GG+LF+R+ + + FTE + + ++ A+ LH
Sbjct: 123 KLHYAFQT--EGK--LYLILDFLRGGDLFTRLSK--EVMFTEEDVKFYLAELALALDHLH 176
Query: 159 SHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTP--CYTPYYVAPEVLGP 216
S I +RD+KPEN+L +++ +K+TDFG +KE + + C T Y+APEV+
Sbjct: 177 SLGIIYRDLKPENILL---DEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNR 233
Query: 217 EKYDKSCDMWSLGVIMYILLCGFPPFY-SNTGQAISPGMKRRIRLGQYGFPNPEWSEVSE 275
+ +S D WS GV+M+ +L G PF + + ++ +K ++ + Q+ +S
Sbjct: 234 RGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQF---------LSG 284
Query: 276 DAKQLIRLLLKTDPTERL-----TITQFMNHPW 303
+A+ L+R L K +P RL + + HP+
Sbjct: 285 EAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPF 317
>gi|39752689 MAP kinase-interacting serine/threonine kinase 1
isoform 2 [Homo sapiens]
Length = 347
Score = 175 bits (443), Expect = 7e-44
Identities = 107/330 (32%), Positives = 173/330 (52%), Gaps = 41/330 (12%)
Query: 8 EQGGPVPPPVAPGGPGLGGAPGGRRE---PKKYAVTDDYQLSKQVLGLGVNGKVLECFHR 64
E G P P+A G GR P K+ D Y+L+ ++LG G KV
Sbjct: 12 EMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFE--DMYKLTSELLGEGAYAKVQGAVSL 69
Query: 65 RTGQKCALKLL-----YDSPKARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIME 119
+ G++ A+K++ + + +EV+ +Q G +I+ +++ +E+ ++ E
Sbjct: 70 QNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTR----FYLVFE 125
Query: 120 CMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEK 179
++GG + + IQ++ + F EREA+ ++RD+ A+ FLH+ IAHRD+KPEN+L S EK
Sbjct: 126 KLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEK 183
Query: 180 DAVLKLTDFGFAK---------ETTQNALQTPCYTPYYVAPEVL-----GPEKYDKSCDM 225
+ +K+ DF T L TPC + Y+APEV+ YDK CD+
Sbjct: 184 VSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDL 243
Query: 226 WSLGVIMYILLCGFPPFYSNTG-----------QAISPGMKRRIRLGQYGFPNPEWSEVS 274
WSLGV++YI+L G+PPF + G + + I+ G+Y FP+ +W+ +S
Sbjct: 244 WSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHIS 303
Query: 275 EDAKQLIRLLLKTDPTERLTITQFMNHPWI 304
+AK LI LL D +RL+ Q + HPW+
Sbjct: 304 SEAKDLISKLLVRDAKQRLSAAQVLQHPWV 333
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 174 bits (442), Expect = 9e-44
Identities = 96/281 (34%), Positives = 161/281 (57%), Gaps = 12/281 (4%)
Query: 40 TDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPK-ARQEVDHHWQASGGPHIV 98
TD Y++ K+ +G+G C H+ T + A+K++ S + +E++ + P+I+
Sbjct: 419 TDGYEV-KEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNII 477
Query: 99 CILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLH 158
+ DVY++ + + ++ E M+GGEL +I + + F+EREA+ ++ I +++LH
Sbjct: 478 TLKDVYDDGKY----VYVVTELMKGGELLDKILRQ--KFFSEREASAVLFTITKTVEYLH 531
Query: 159 SHNIAHRDVKPENLLYTSKEKDAV-LKLTDFGFAKE--TTQNALQTPCYTPYYVAPEVLG 215
+ + HRD+KP N+LY + + +++ DFGFAK+ L TPCYT +VAPEVL
Sbjct: 532 AQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLK 591
Query: 216 PEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSE 275
+ YD +CD+WSLGV++Y +L G+ PF +N + RI G++ W+ VS+
Sbjct: 592 RQGYDAACDIWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARIGSGKFSLSGGYWNSVSD 650
Query: 276 DAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQTPLH 316
AK L+ +L DP +RLT + HPWI +PQ L+
Sbjct: 651 TAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLN 691
Score = 102 bits (254), Expect = 6e-22
Identities = 84/275 (30%), Positives = 141/275 (51%), Gaps = 33/275 (12%)
Query: 32 REPKKYAVTDDYQLSKQVLGLGVNGKVL-----------ECFHRRTGQKCALKLLYDSPK 80
+E + A ++L K VLG G GKV + + + +K LK+ D +
Sbjct: 57 KEGHEKADPSQFELLK-VLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVR-DRVR 114
Query: 81 ARQEVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTE 140
+ E D + + P IV + ++ GK L +I++ + GG+LF+R+ + + FTE
Sbjct: 115 TKMERDILVEVNH-PFIVKLHYAFQT--EGK--LYLILDFLRGGDLFTRLSK--EVMFTE 167
Query: 141 REAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQ 200
+ + ++ A+ LHS I +RD+KPEN+L +++ +KLTDFG +KE+ + +
Sbjct: 168 EDVKFYLAELALALDHLHSLGIIYRDLKPENILL---DEEGHIKLTDFGLSKESIDHEKK 224
Query: 201 TP--CYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRI 258
C T Y+APEV+ + +S D WS GV+M+ +L G PF + + M +
Sbjct: 225 AYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKE-TMTMILKA 283
Query: 259 RLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERL 293
+LG F +PE A+ L+R+L K +P RL
Sbjct: 284 KLGMPQFLSPE-------AQSLLRMLFKRNPANRL 311
>gi|40018631 MAP kinase-interacting serine/threonine kinase 2
isoform 1 [Homo sapiens]
Length = 414
Score = 174 bits (440), Expect = 2e-43
Identities = 107/318 (33%), Positives = 164/318 (51%), Gaps = 38/318 (11%)
Query: 41 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSP-----KARQEVDHHWQASGGP 95
D YQL + VLG G + +V C + T Q+ A+K++ P + +EV+ +Q G
Sbjct: 81 DVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHR 140
Query: 96 HIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQ 155
+++ +++ +E ++ E M GG + S I +R + F E EA+ +++D+ +A+
Sbjct: 141 NVLELIEFFEEEDR----FYLVFEKMRGGSILSHIHKR--RHFNELEASVVVQDVASALD 194
Query: 156 FLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNA---------LQTPCYTP 206
FLH+ IAHRD+KPEN+L + + +K+ DF N L TPC +
Sbjct: 195 FLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSA 254
Query: 207 YYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQ-----------AI 250
Y+APEV+ YDK CD+WSLGVI+YILL G+PPF G A
Sbjct: 255 EYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPAC 314
Query: 251 SPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVV 310
+ I+ G+Y FP+ +W+ +S AK LI LL D +RL+ Q + HPW+
Sbjct: 315 QNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQG--CA 372
Query: 311 PQTPLHTARVLQEDKDHW 328
P+ L T VLQ H+
Sbjct: 373 PENTLPTPMVLQRWDSHF 390
>gi|40018627 MAP kinase-interacting serine/threonine kinase 2
isoform 2 [Homo sapiens]
Length = 465
Score = 172 bits (437), Expect = 3e-43
Identities = 106/314 (33%), Positives = 163/314 (51%), Gaps = 38/314 (12%)
Query: 41 DDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSP-----KARQEVDHHWQASGGP 95
D YQL + VLG G + +V C + T Q+ A+K++ P + +EV+ +Q G
Sbjct: 81 DVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHR 140
Query: 96 HIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQ 155
+++ +++ +E ++ E M GG + S I +R + F E EA+ +++D+ +A+
Sbjct: 141 NVLELIEFFEEEDR----FYLVFEKMRGGSILSHIHKR--RHFNELEASVVVQDVASALD 194
Query: 156 FLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNA---------LQTPCYTP 206
FLH+ IAHRD+KPEN+L + + +K+ DF N L TPC +
Sbjct: 195 FLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSA 254
Query: 207 YYVAPEVL-----GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQ-----------AI 250
Y+APEV+ YDK CD+WSLGVI+YILL G+PPF G A
Sbjct: 255 EYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPAC 314
Query: 251 SPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVV 310
+ I+ G+Y FP+ +W+ +S AK LI LL D +RL+ Q + HPW+
Sbjct: 315 QNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQG--CA 372
Query: 311 PQTPLHTARVLQED 324
P+ L T VLQ +
Sbjct: 373 PENTLPTPMVLQRN 386
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 170 bits (430), Expect = 2e-42
Identities = 108/292 (36%), Positives = 162/292 (55%), Gaps = 20/292 (6%)
Query: 21 GPGLGGAPGGRREPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPK 80
GPG + G + P +T+ Y++ + + G G V EC R T ++ ALK++ S
Sbjct: 370 GPGEEVSEEGFQIPA--TITERYKVGRTI-GDGNFAVVKECVERSTAREYALKIIKKSKC 426
Query: 81 ARQEVDHHWQAS-----GGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGD 135
+E + S P+IV +++ + L ++ME ++GG+LF I
Sbjct: 427 RGKEHMIQNEVSILRRVKHPNIVLLIEEMDVPTE----LYLVMELVKGGDLFDAITSTNK 482
Query: 136 QAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLL-YTSKEKDAVLKLTDFGFAKET 194
+TER+A+ ++ ++ +AI++LHS NI HRD+KPENLL Y ++ LKL DFG A
Sbjct: 483 --YTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLAT-I 539
Query: 195 TQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFY-SNTGQAISPG 253
L T C TP YVAPE++ Y D+W+ GVI YILLCGFPPF S Q +
Sbjct: 540 VDGPLYTVCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEV--- 596
Query: 254 MKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWIN 305
+ +I +GQ FP+P W VS+ AK+LI ++L D +R + Q + HPW+N
Sbjct: 597 LFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVN 648
>gi|54112407 protein kinase CHK2 isoform c [Homo sapiens]
Length = 586
Score = 169 bits (429), Expect = 3e-42
Identities = 101/283 (35%), Positives = 162/283 (57%), Gaps = 27/283 (9%)
Query: 38 AVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHI 97
A+ D+Y +SK LG G G+V F R+T +K A+K++ K + + +A ++
Sbjct: 258 ALRDEYIMSK-TLGSGACGEVKLAFERKTCKKVAIKII---SKRKFAIGSAREADPALNV 313
Query: 98 VCILDVYENMHHGKRCLL------------IIMECMEGGELFSRIQERGDQAFTEREAAE 145
+++ + ++H C++ I++E MEGGELF ++ G++ E
Sbjct: 314 ETEIEILKKLNHP--CIIKIKNFFDAEDYYIVLELMEGGELFDKVV--GNKRLKEATCKL 369
Query: 146 IMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNAL-QTPCY 204
+ A+Q+LH + I HRD+KPEN+L +S+E+D ++K+TDFG +K + +L +T C
Sbjct: 370 YFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCG 429
Query: 205 TPYYVAPEVL---GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLG 261
TP Y+APEVL G Y+++ D WSLGVI++I L G+PPF + Q +K +I G
Sbjct: 430 TPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQV---SLKDQITSG 486
Query: 262 QYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWI 304
+Y F W+EVSE A L++ LL DP R T + + HPW+
Sbjct: 487 KYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 529
>gi|6005850 protein kinase CHK2 isoform a [Homo sapiens]
Length = 543
Score = 169 bits (429), Expect = 3e-42
Identities = 101/283 (35%), Positives = 162/283 (57%), Gaps = 27/283 (9%)
Query: 38 AVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHI 97
A+ D+Y +SK LG G G+V F R+T +K A+K++ K + + +A ++
Sbjct: 215 ALRDEYIMSK-TLGSGACGEVKLAFERKTCKKVAIKII---SKRKFAIGSAREADPALNV 270
Query: 98 VCILDVYENMHHGKRCLL------------IIMECMEGGELFSRIQERGDQAFTEREAAE 145
+++ + ++H C++ I++E MEGGELF ++ G++ E
Sbjct: 271 ETEIEILKKLNHP--CIIKIKNFFDAEDYYIVLELMEGGELFDKVV--GNKRLKEATCKL 326
Query: 146 IMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNAL-QTPCY 204
+ A+Q+LH + I HRD+KPEN+L +S+E+D ++K+TDFG +K + +L +T C
Sbjct: 327 YFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCG 386
Query: 205 TPYYVAPEVL---GPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLG 261
TP Y+APEVL G Y+++ D WSLGVI++I L G+PPF + Q +K +I G
Sbjct: 387 TPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQV---SLKDQITSG 443
Query: 262 QYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWI 304
+Y F W+EVSE A L++ LL DP R T + + HPW+
Sbjct: 444 KYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWL 486
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 168 bits (426), Expect = 7e-42
Identities = 111/287 (38%), Positives = 156/287 (54%), Gaps = 20/287 (6%)
Query: 28 PGGRREPKKYAV----TDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQ 83
P GR+ P+ + + + + +V+G G V EC HR T Q A+K++ S +
Sbjct: 337 PSGRK-PRPMGIIAANVEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGK 395
Query: 84 E--VDHHW---QASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAF 138
E VD Q+ P+IV + +VYE + +I+E ++GG+LF I E F
Sbjct: 396 EDMVDSEILIIQSLSHPNIVKLHEVYETDME----IYLILEYVQGGDLFDAIIE--SVKF 449
Query: 139 TEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKE-KDAVLKLTDFGFAKETTQN 197
E +AA ++ D+ A+ +H +I HRD+KPENLL E K LKL DFG AK +
Sbjct: 450 PEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVR- 508
Query: 198 ALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRR 257
+ T C TP YVAPE+L + Y DMW+ GVI+YILLCGFPPF S + +
Sbjct: 509 PIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYILLCGFPPFRS--PERDQDELFNI 566
Query: 258 IRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWI 304
I+LG + F P W +S+ AK L+ LL DP +R T Q + HPWI
Sbjct: 567 IQLGHFEFLPPYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHPWI 613
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 167 bits (422), Expect = 2e-41
Identities = 93/273 (34%), Positives = 152/273 (55%), Gaps = 12/273 (4%)
Query: 43 YQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPK-ARQEVDHHWQASGGPHIVCIL 101
Y+L K+ +G+G C H T + A+K++ S + +E++ + P+I+ +
Sbjct: 426 YEL-KEDIGVGSYSVCKRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLK 484
Query: 102 DVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHN 161
DV+++ R + ++ + M+GGEL RI ++ + F+EREA++I+ I + +LH
Sbjct: 485 DVFDD----GRYVYLVTDLMKGGELLDRILKQ--KCFSEREASDILYVISKTVDYLHCQG 538
Query: 162 IAHRDVKPENLLYTSKEKDA-VLKLTDFGFAKETT--QNALQTPCYTPYYVAPEVLGPEK 218
+ HRD+KP N+LY + A +++ DFGFAK+ L TPCYT +VAPEVL +
Sbjct: 539 VVHRDLKPSNILYMDESASADSIRICDFGFAKQLRGENGLLLTPCYTANFVAPEVLMQQG 598
Query: 219 YDKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAK 278
YD +CD+WSLGV+ Y +L G+ PF +N + RI G++ W +S+ AK
Sbjct: 599 YDAACDIWSLGVLFYTMLAGYTPF-ANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAK 657
Query: 279 QLIRLLLKTDPTERLTITQFMNHPWINQSMVVP 311
L+ +L DP +R T Q + H WI +P
Sbjct: 658 DLLSHMLHMDPHQRYTAEQILKHSWITHRDQLP 690
Score = 100 bits (248), Expect = 3e-21
Identities = 79/259 (30%), Positives = 135/259 (52%), Gaps = 32/259 (12%)
Query: 48 QVLGLGVNGKVLECFHRRTG----QKCALKLLYD-SPKARQEVDHHWQAS-----GGPHI 97
+VLG G GKV ++TG Q A+K+L S K R V + P I
Sbjct: 77 KVLGQGSFGKVF-LVRKKTGPDAGQLYAMKVLKKASLKVRDRVRTKMERDILVEVNHPFI 135
Query: 98 VCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFL 157
V + ++ GK L +I++ + GG++F+R+ + + FTE + + ++ A+ L
Sbjct: 136 VKLHYAFQT--EGK--LYLILDFLRGGDVFTRLSK--EVLFTEEDVKFYLAELALALDHL 189
Query: 158 HSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETT--QNALQTPCYTPYYVAPEVLG 215
H I +RD+KPEN+L ++ +KLTDFG +KE+ + + C T Y+APEV+
Sbjct: 190 HQLGIVYRDLKPENILL---DEIGHIKLTDFGLSKESVDQEKKAYSFCGTVEYMAPEVVN 246
Query: 216 PEKYDKSCDMWSLGVIMYILLCGFPPFY-SNTGQAISPGMKRRIRLGQYGFPNPEWSEVS 274
+ +S D WS GV+M+ +L G PF + + ++ +K ++ + Q+ +S
Sbjct: 247 RRGHSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGMPQF---------LS 297
Query: 275 EDAKQLIRLLLKTDPTERL 293
+A+ L+R+L K +P RL
Sbjct: 298 AEAQSLLRMLFKRNPANRL 316
>gi|27901803 protein serine kinase H1 [Homo sapiens]
Length = 424
Score = 165 bits (418), Expect = 6e-41
Identities = 106/311 (34%), Positives = 158/311 (50%), Gaps = 22/311 (7%)
Query: 6 AEEQGGPVPPPVAPGGPGLGGAPGGRREPKKYAVTDDYQLS-----KQVLGLGVNGKVLE 60
A + P P P G P R KY D +++ K ++G G +V+
Sbjct: 55 ASQYAHPCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVR 114
Query: 61 CFHRRTGQKCALKLLYDSPKARQEVDHH----WQASGGPHIVCILDVYENMHHGKRCLLI 116
HR T Q A+K++ + +EV + +I+ +++V+E + +
Sbjct: 115 VEHRATRQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQER----VYM 170
Query: 117 IMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTS 176
+ME GGELF RI +G +FTER+A +++ + +++LH+ I HRD+KPENLLY
Sbjct: 171 VMELATGGELFDRIIAKG--SFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYH 228
Query: 177 KEKDAVLKLTDFGFA---KETTQNALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMY 233
D+ + +TDFG A K+ ++T C TP Y+APEVL + Y S DMW+LGVI Y
Sbjct: 229 PGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAY 288
Query: 234 ILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERL 293
ILL G PF + + R+I G+Y + W VS AK I LL DP R+
Sbjct: 289 ILLSGTMPFEDDN----RTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARM 344
Query: 294 TITQFMNHPWI 304
T Q + HPW+
Sbjct: 345 TALQALRHPWV 355
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,120,190
Number of Sequences: 37866
Number of extensions: 863950
Number of successful extensions: 9064
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 596
Number of HSP's successfully gapped in prelim test: 237
Number of HSP's that attempted gapping in prelim test: 6143
Number of HSP's gapped (non-prelim): 1777
length of query: 382
length of database: 18,247,518
effective HSP length: 104
effective length of query: 278
effective length of database: 14,309,454
effective search space: 3978028212
effective search space used: 3978028212
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.