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Search of human proteins with 4758666
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758666 LATS homolog 1 [Homo sapiens]
(1130 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758666 LATS homolog 1 [Homo sapiens] 2328 0.0
gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens] 1033 0.0
gi|24307971 serine/threonine kinase 38 like [Homo sapiens] 387 e-107
gi|6005814 serine/threonine kinase 38 [Homo sapiens] 377 e-104
gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo s... 253 6e-67
gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo s... 253 6e-67
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 252 1e-66
gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Hom... 247 4e-65
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 247 5e-65
gi|115527097 CDC42-binding protein kinase beta [Homo sapiens] 246 1e-64
gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo s... 243 1e-63
gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo s... 243 1e-63
gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo sa... 243 1e-63
gi|148727255 microtubule associated serine/threonine kinase fami... 240 6e-63
gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo s... 239 1e-62
gi|150170729 microtubule associated serine/threonine kinase 3 [H... 231 2e-60
gi|112363080 microtubule associated serine/threonine kinase 2 [H... 228 2e-59
gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Ho... 220 7e-57
gi|45120119 microtubule associated serine/threonine kinase 1 [Ho... 219 9e-57
gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 218 2e-56
gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 is... 218 2e-56
gi|32698688 citron [Homo sapiens] 216 1e-55
gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 211 2e-54
gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 is... 211 2e-54
gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha... 211 4e-54
gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Ho... 208 3e-53
gi|46909584 cAMP-dependent protein kinase catalytic subunit alph... 207 3e-53
gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens] 207 5e-53
gi|33636738 cAMP-dependent protein kinase catalytic subunit beta... 203 9e-52
gi|4506057 cAMP-dependent protein kinase catalytic subunit beta ... 202 1e-51
>gi|4758666 LATS homolog 1 [Homo sapiens]
Length = 1130
Score = 2328 bits (6032), Expect = 0.0
Identities = 1130/1130 (100%), Positives = 1130/1130 (100%)
Query: 1 MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTE 60
MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTE
Sbjct: 1 MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTE 60
Query: 61 DPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVI 120
DPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVI
Sbjct: 61 DPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVI 120
Query: 121 QALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKG 180
QALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKG
Sbjct: 121 QALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKG 180
Query: 181 SKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPP 240
SKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPP
Sbjct: 181 SKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPP 240
Query: 241 QVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGY 300
QVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGY
Sbjct: 241 QVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGY 300
Query: 301 PPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQ 360
PPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQ
Sbjct: 301 PPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQ 360
Query: 361 NVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNME 420
NVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNME
Sbjct: 361 NVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNME 420
Query: 421 LYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQ 480
LYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQ
Sbjct: 421 LYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQ 480
Query: 481 PSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNV 540
PSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNV
Sbjct: 481 PSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNV 540
Query: 541 TVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENV 600
TVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENV
Sbjct: 541 TVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENV 600
Query: 601 DSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHR 660
DSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHR
Sbjct: 601 DSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHR 660
Query: 661 KKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVC 720
KKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVC
Sbjct: 661 KKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVC 720
Query: 721 LARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF 780
LARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF
Sbjct: 721 LARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF 780
Query: 781 VMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDG 840
VMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDG
Sbjct: 781 VMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDG 840
Query: 841 HIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAAR 900
HIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAAR
Sbjct: 841 HIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAAR 900
Query: 901 QHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQM 960
QHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQM
Sbjct: 901 QHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQM 960
Query: 961 KVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLR 1020
KVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLR
Sbjct: 961 KVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLR 1020
Query: 1021 QQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTF 1080
QQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTF
Sbjct: 1021 QQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTF 1080
Query: 1081 RRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV 1130
RRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV
Sbjct: 1081 RRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV 1130
>gi|126507091 LATS, large tumor suppressor, homolog 2 [Homo sapiens]
Length = 1088
Score = 1033 bits (2670), Expect = 0.0
Identities = 594/1149 (51%), Positives = 729/1149 (63%), Gaps = 105/1149 (9%)
Query: 13 MRPKTFPASNYTVSSRQMLQEIRESLRNLSKPS-----------DAAKAEHNMSKMSTED 61
MRPKTFPA+ Y+ +SRQ LQEIRE L+ SK S + A+ SK +T
Sbjct: 1 MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSDTSLDAKVLGSKDATRQ 60
Query: 62 PRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVIQ 121
+Q+R PKFG + KAL+EIR SLLPFANE+ +S + +EVN QMLQ+L AG D++M +
Sbjct: 61 QQQMRATPKFGPYQKALREIRYSLLPFANESGTS-AAAEVNRQMLQELVNAGCDQEMAGR 119
Query: 122 ALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKGS 181
AL++T +RSIEAA+E+ISKM Y DPR EQ+ + S G + V R+ S++G+
Sbjct: 120 ALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQ---TSPGKGLMPTPVTRRPSFEGT 176
Query: 182 KESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQ 241
+S +YH S G P G A + P P
Sbjct: 177 GDSF------------ASYHQLS-------GTPYEGPSFGA------DGPTALEEMPRPY 211
Query: 242 VRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYP 301
V + P G P P + K Y ++E + P G P
Sbjct: 212 VDYLFP------------GVGPHGPGHQHQHPPKGYGASVEAAGAHF---PLQGAHYGRP 256
Query: 302 PPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQN 361
+ P+ G+ P + ++ + P+ G G G
Sbjct: 257 HLLVPGEPLG------YGVQRSPSFQSKTPPETGGYASLPTKGQGGPPGAGL-------- 302
Query: 362 VVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNMEL 421
P P P+ A G + L GS + + + S PQS++ P+RNS N++L
Sbjct: 303 AFPPPAAGLYVPHPHHKQA--GPAAHQLHVLGSRS-QVFASDSPPQSLLTPSRNSLNVDL 359
Query: 422 YNISVPGLQTNWPQSSSAPAQSSPSSGHEIP-----TWQPNIPV--RSNSFNN--PLGNR 472
Y + +Q WP ++ A S G E P ++P+ PV R+NSFN+ P
Sbjct: 360 YELGSTSVQ-QWPAATLARRDSLQKPGLEAPPRAHVAFRPDCPVPSRTNSFNSHQPRPGP 418
Query: 473 ASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPF 532
+ S P+ TVTA+T A I PVKS+RVL+PE QTA+ P+HP+W+P P P+P
Sbjct: 419 PGKAEPSLPAPNTVTAVTAAHILHPVKSVRVLRPEPQTAVGPSHPAWVPAPAPAPAPAPA 478
Query: 533 PEGTASNVTVMPPVA-------------EAPNYQGPPPPYPKHLLHQNPSVP-PYESISK 578
P + +A P+ + PPPPYPKHLL ++ S +S+
Sbjct: 479 PAAEGLDAKEEHALALGGAGAFPLDVEYGGPDRRCPPPPYPKHLLLRSKSEQYDLDSLCA 538
Query: 579 PSKEDQPSLPKE----DESEKSYENVDSGDKEKKQITTSPITVRKNKKDEERRESRIQSY 634
++ + P E D+S KS + D G K+KKQI TSP+ VRKN +DEE+RESRI+SY
Sbjct: 539 GMEQSLRAGPNEPEGGDKSRKSAKG-DKGGKDKKQIQTSPVPVRKNSRDEEKRESRIKSY 597
Query: 635 SPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIR 694
SP AFKFFMEQHVENV+K++QQ+++R+ QLE EM + GL + Q+QMRK+L QKESNY R
Sbjct: 598 SPYAFKFFMEQHVENVIKTYQQKVNRRLQLEQEMAKAGLCEAEQEQMRKILYQKESNYNR 657
Query: 695 LKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAER 754
LKRAKMDKSMFVKIKTLGIGAFGEVCLA KVDT ALYA KTLRKKDVL RNQVAHVKAER
Sbjct: 658 LKRAKMDKSMFVKIKTLGIGAFGEVCLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAER 717
Query: 755 DILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTC 814
DILAEADNEWVV+LYYSFQDKD+LYFVMDYIPGGDMMSLLIRM +FPE LARFYIAELT
Sbjct: 718 DILAEADNEWVVKLYYSFQDKDSLYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTL 777
Query: 815 AVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMD 874
A+ESVHKMGFIHRDIKPDNILID DGHIKLTDFGLCTGFRWTH+SKYYQ G H RQDSM+
Sbjct: 778 AIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSME 837
Query: 875 FSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWW 934
S+ W D S+CRCGDRLK LE+RA +QHQRCLAHSLVGTPNYIAPEVLLR GYTQLCDWW
Sbjct: 838 PSDLWDDVSNCRCGDRLKTLEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWW 897
Query: 935 SVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPED 994
SVGVILFEMLVGQPPFLA TP ETQ+KVINW+ +LHIP Q KLSPEA DLI KLC +
Sbjct: 898 SVGVILFEMLVGQPPFLAPTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADH 957
Query: 995 RLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNE- 1053
RLG+NGAD++KAHPFF IDFSSD+R+Q A Y+P I+HP DTSNFDPVD + W+D +E
Sbjct: 958 RLGRNGADDLKAHPFFSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEG 1017
Query: 1054 EENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSE-QQSD 1112
DTL N KHPEHAFYEFTFRRFFDDNGYP+ PKP E ++ S+ + SD
Sbjct: 1018 STKAWDTLTS--PNNKHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSD 1075
Query: 1113 EDDQNTGSE 1121
DQ G +
Sbjct: 1076 LVDQTEGCQ 1084
>gi|24307971 serine/threonine kinase 38 like [Homo sapiens]
Length = 464
Score = 387 bits (994), Expect = e-107
Identities = 192/444 (43%), Positives = 287/444 (64%), Gaps = 22/444 (4%)
Query: 640 KFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAK 699
K +E N++ H++R R+K+LE M GL+ + + R +KE+ ++RLKR +
Sbjct: 25 KLTLENFYSNLILQHEERETRQKKLEVAMEEEGLADEEKKLRRSQHARKETEFLRLKRTR 84
Query: 700 MDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAE 759
+ F +K +G GAFGEV L +K DT +YA K LRK D+L + QVAH++AERDIL E
Sbjct: 85 LGLDDFESLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVE 144
Query: 760 ADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESV 819
AD WVV+++YSFQDK NLY +M+++PGGDMM+LL++ E +FYI+E A++++
Sbjct: 145 ADGAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAI 204
Query: 820 HKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEW 879
H++GFIHRDIKPDN+L+D GH+KL+DFGLCTG + H +++Y++ H F N
Sbjct: 205 HQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFSFQN-- 262
Query: 880 GDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVI 939
+S R + K +++R LA+S VGTP+YIAPEV ++TGY +LCDWWS+GVI
Sbjct: 263 --MNSKRKAETWK--------KNRRQLAYSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVI 312
Query: 940 LFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKN 999
++EML+G PPF ++TP ET KV+NW+ +L PP+ +S +A DLI++ C E+R+G +
Sbjct: 313 MYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISEKAKDLILRFCIDSENRIGNS 372
Query: 1000 GADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVND 1059
G +EIK HPFF+ +D+ +R++ A+ +I DTSNFD D E + +
Sbjct: 373 GVEEIKGHPFFEGVDW-EHIRERPAAIPIEIKSIDDTSNFD---------DFPESDILQP 422
Query: 1060 TLNGWYKNGKHPEHAFYEFTFRRF 1083
N + K + F +T++RF
Sbjct: 423 VPNTTEPDYKSKDWVFLNYTYKRF 446
>gi|6005814 serine/threonine kinase 38 [Homo sapiens]
Length = 465
Score = 377 bits (967), Expect = e-104
Identities = 190/444 (42%), Positives = 284/444 (63%), Gaps = 19/444 (4%)
Query: 640 KFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAK 699
K +E N++ H++R R+K+LE M GL + + R +KE+ ++RLKR +
Sbjct: 24 KVTLENFYSNLIAQHEEREMRQKKLEKVMEEEGLKDEEKRLRRSAHARKETEFLRLKRTR 83
Query: 700 MDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAE 759
+ F +K +G GAFGEV L +K DT +YA K LRK D+L + QV H++AERDIL E
Sbjct: 84 LGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVE 143
Query: 760 ADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESV 819
AD+ WVV+++YSFQDK NLY +M+++PGGDMM+LL++ E +FYIAE A++S+
Sbjct: 144 ADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSI 203
Query: 820 HKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEW 879
H++GFIHRDIKPDN+L+D GH+KL+DFGLCTG + H +++Y++ +H F N
Sbjct: 204 HQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQN-- 261
Query: 880 GDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVI 939
+S R + K +++R LA S VGTP+YIAPEV ++TGY +LCDWWS+GVI
Sbjct: 262 --MNSKRKAETWK--------RNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVI 311
Query: 940 LFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKN 999
++EML+G PPF ++TP ET KV+NW+ +L PP+ +S +A DLI++ C E R+G
Sbjct: 312 MYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEWEHRIGAP 371
Query: 1000 GADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVND 1059
G +EIK++ FF+ +D+ +R++ A+ +I DTSNFD + N +
Sbjct: 372 GVEEIKSNSFFEGVDW-EHIRERPAAISIEIKSIDDTSNFDEFPESDILKPTVATSNHPE 430
Query: 1060 TLNGWYKNGKHPEHAFYEFTFRRF 1083
T + K+ + F +T++RF
Sbjct: 431 T------DYKNKDWVFINYTYKRF 448
>gi|30089962 CDC42-binding protein kinase alpha isoform B [Homo
sapiens]
Length = 1719
Score = 253 bits (647), Expect = 6e-67
Identities = 142/377 (37%), Positives = 213/377 (56%), Gaps = 55/377 (14%)
Query: 694 RLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAE 753
++K+ ++ + F +K +G GAFGEV + + + ++A K L K ++L R + A + E
Sbjct: 66 KVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREE 125
Query: 754 RDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRM-GIFPESLARFYIAEL 812
RD+L DN+W+ L+Y+FQD +NLY VMDY GGD+++LL + PE +ARFY+AE+
Sbjct: 126 RDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEM 185
Query: 813 TCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDS 872
A++SVH++ ++HRDIKPDNIL+D +GHI+L DFG C
Sbjct: 186 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSC---------------------- 223
Query: 873 MDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLL-----RTGY 927
LK +E + + VGTP+YI+PE+L + Y
Sbjct: 224 ------------------LKLMEDGTVQ------SSVAVGTPDYISPEILQAMEDGKGRY 259
Query: 928 TQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQ-AKLSPEASDLII 986
CDWWS+GV ++EML G+ PF A++ +ET K++N + P Q +S A DLI
Sbjct: 260 GPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIR 319
Query: 987 KLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDK 1046
+L E RLG+NG ++ K HPFF ID+ ++R A YIP+++ PTDTSNFD VD D
Sbjct: 320 RLICSREHRLGQNGIEDFKKHPFFSGIDW-DNIRNCEAPYIPEVSSPTDTSNFD-VDDDC 377
Query: 1047 LWSDDNEEENVNDTLNG 1063
L + + + +G
Sbjct: 378 LKNSETMPPPTHTAFSG 394
>gi|30089960 CDC42-binding protein kinase alpha isoform A [Homo
sapiens]
Length = 1638
Score = 253 bits (647), Expect = 6e-67
Identities = 142/377 (37%), Positives = 213/377 (56%), Gaps = 55/377 (14%)
Query: 694 RLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAE 753
++K+ ++ + F +K +G GAFGEV + + + ++A K L K ++L R + A + E
Sbjct: 66 KVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREE 125
Query: 754 RDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRM-GIFPESLARFYIAEL 812
RD+L DN+W+ L+Y+FQD +NLY VMDY GGD+++LL + PE +ARFY+AE+
Sbjct: 126 RDVLVNGDNKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEM 185
Query: 813 TCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDS 872
A++SVH++ ++HRDIKPDNIL+D +GHI+L DFG C
Sbjct: 186 VIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSC---------------------- 223
Query: 873 MDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLL-----RTGY 927
LK +E + + VGTP+YI+PE+L + Y
Sbjct: 224 ------------------LKLMEDGTVQ------SSVAVGTPDYISPEILQAMEDGKGRY 259
Query: 928 TQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQ-AKLSPEASDLII 986
CDWWS+GV ++EML G+ PF A++ +ET K++N + P Q +S A DLI
Sbjct: 260 GPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIR 319
Query: 987 KLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDK 1046
+L E RLG+NG ++ K HPFF ID+ ++R A YIP+++ PTDTSNFD VD D
Sbjct: 320 RLICSREHRLGQNGIEDFKKHPFFSGIDW-DNIRNCEAPYIPEVSSPTDTSNFD-VDDDC 377
Query: 1047 LWSDDNEEENVNDTLNG 1063
L + + + +G
Sbjct: 378 LKNSETMPPPTHTAFSG 394
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 252 bits (644), Expect = 1e-66
Identities = 143/358 (39%), Positives = 201/358 (56%), Gaps = 52/358 (14%)
Query: 694 RLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAE 753
+++ +M + +K +G GAFGEV L R T+ +YA K L K +++ R+ A E
Sbjct: 65 KIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEE 124
Query: 754 RDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELT 813
RDI+A A++ WVV+L+Y+FQD LY VM+Y+PGGD+++L+ + PE ARFY AE+
Sbjct: 125 RDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWARFYTAEVV 183
Query: 814 CAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSM 873
A++++H MGFIHRD+KPDN+L+D+ GH+KL DFG C M
Sbjct: 184 LALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTC----------------------M 221
Query: 874 DFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTG----YTQ 929
+ E RC + VGTP+YI+PEVL G Y +
Sbjct: 222 KMNKE----GMVRC--------------------DTAVGTPDYISPEVLKSQGGDGYYGR 257
Query: 930 LCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLC 989
CDWWSVGV L+EMLVG PF A + + T K++N + SL P +S EA +LI
Sbjct: 258 ECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFL 317
Query: 990 RGPEDRLGKNGADEIKAHPFFKTIDFS-SDLRQQSASYIPKITHPTDTSNFDPVDPDK 1046
E RLG+NG +EIK H FFK ++ LR A +P ++ DTSNFD ++ DK
Sbjct: 318 TDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDK 375
>gi|156766068 CDC42 binding protein kinase gamma (DMPK-like) [Homo
sapiens]
Length = 1551
Score = 247 bits (631), Expect = 4e-65
Identities = 138/361 (38%), Positives = 203/361 (56%), Gaps = 55/361 (15%)
Query: 694 RLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAE 753
++K ++ + F +K +G GAFGEV + R+ DT ++A K L K ++L R + A + E
Sbjct: 60 KVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREE 119
Query: 754 RDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRM-GIFPESLARFYIAEL 812
RD+L + D+ WV L+Y+FQD++ LY VMDY GGD+++LL R P LA+FY+AE+
Sbjct: 120 RDVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEM 179
Query: 813 TCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDS 872
A+ S+H++G++HRD+KPDN+L+D +GHI+L DFG C
Sbjct: 180 VLAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLN------------------ 221
Query: 873 MDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLL-----RTGY 927
+N D S VGTP+YI+PE+L + Y
Sbjct: 222 ---TNGMVDSSVA-------------------------VGTPDYISPEILQAMEEGKGHY 253
Query: 928 TQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSP-EASDLII 986
CDWWS+GV +E+L G+ PF A++ +ET K++N + L PP P A DLI
Sbjct: 254 GPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIR 313
Query: 987 KLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDK 1046
+L E+RLG+ G D+ + HPFF+ +D+ L +A YIP++ P DTSNFD VD D
Sbjct: 314 QLLCRQEERLGRGGLDDFRNHPFFEGVDWER-LASSTAPYIPELRGPMDTSNFD-VDDDT 371
Query: 1047 L 1047
L
Sbjct: 372 L 372
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 247 bits (630), Expect = 5e-65
Identities = 137/358 (38%), Positives = 204/358 (56%), Gaps = 52/358 (14%)
Query: 694 RLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAE 753
+++ +M + +K +G GAFGEV L R ++ +YA K L K +++ R+ A E
Sbjct: 81 KIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEE 140
Query: 754 RDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELT 813
RDI+A A++ WVV+L+Y+FQD LY VM+Y+PGGD+++L+ + PE A+FY AE+
Sbjct: 141 RDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDV-PEKWAKFYTAEVV 199
Query: 814 CAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSM 873
A++++H MG IHRD+KPDN+L+D+ GH+KL DFG C M
Sbjct: 200 LALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCM--------------------KM 239
Query: 874 DFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTG----YTQ 929
D + C + VGTP+YI+PEVL G Y +
Sbjct: 240 D------ETGMVHC--------------------DTAVGTPDYISPEVLKSQGGDGFYGR 273
Query: 930 LCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLC 989
CDWWSVGV L+EMLVG PF A + + T K+++ + SL P A++S A +LI
Sbjct: 274 ECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFL 333
Query: 990 RGPEDRLGKNGADEIKAHPFFKTIDFSSD-LRQQSASYIPKITHPTDTSNFDPVDPDK 1046
E RLG+NG +EI+ HPFFK + D +R+ +A +P+++ D+SNFD ++ DK
Sbjct: 334 TDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDK 391
>gi|115527097 CDC42-binding protein kinase beta [Homo sapiens]
Length = 1711
Score = 246 bits (627), Expect = 1e-64
Identities = 147/401 (36%), Positives = 220/401 (54%), Gaps = 60/401 (14%)
Query: 695 LKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAER 754
+K ++ + F IK +G GAFGEV + + +T+ +YA K L K ++L R + A + ER
Sbjct: 66 VKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREER 125
Query: 755 DILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRM-GIFPESLARFYIAELT 813
D+L D +W+ L+Y+FQD+++LY VMDY GGD+++LL + PE +ARFYI E+
Sbjct: 126 DVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMV 185
Query: 814 CAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSM 873
A++S+H++ ++HRDIKPDN+L+D +GHI+L DFG C + D Q S+
Sbjct: 186 LAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSC----------LKMNDDGTVQSSV 235
Query: 874 DFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVL--LRTG---YT 928
VGTP+YI+PE+L + G Y
Sbjct: 236 ------------------------------------AVGTPDYISPEILQAMEDGMGKYG 259
Query: 929 QLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQ-AKLSPEASDLIIK 987
CDWWS+GV ++EML G+ PF A++ +ET K++N + P +S EA DLI +
Sbjct: 260 PECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQR 319
Query: 988 LCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKL 1047
L E RLG+NG ++ K H FF+ +++ ++R A YIP ++ P+DTSNFD VD D L
Sbjct: 320 LICSRERRLGQNGIEDFKKHAFFEGLNW-ENIRNLEAPYIPDVSSPSDTSNFD-VDDDVL 377
Query: 1048 WSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNG 1088
N E + G+ +G H + FT F D G
Sbjct: 378 ---RNTEILPPGSHTGF--SGLHLPFIGFTFTTESCFSDRG 413
>gi|126091040 myotonic dystrophy protein kinase isoform 4 [Homo
sapiens]
Length = 625
Score = 243 bits (619), Expect = 1e-63
Identities = 140/383 (36%), Positives = 208/383 (54%), Gaps = 57/383 (14%)
Query: 671 VGLSQDAQDQ-MRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKA 729
+G S+ AQD+ + L E +RLK ++ + F +K +G GAF EV + + T
Sbjct: 36 LGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQ 95
Query: 730 LYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGD 789
+YA K + K D+L R +V+ + ERD+L D W+ +L+++FQD++ LY VM+Y GGD
Sbjct: 96 VYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGD 155
Query: 790 MMSLLIRMG-IFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFG 848
+++LL + G P +ARFY+AE+ A++SVH++G++HRDIKPDNIL+DR GHI+L DFG
Sbjct: 156 LLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFG 215
Query: 849 LCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAH 908
C L+ RA + +A
Sbjct: 216 SC-------------------------------------------LKLRADGTVRSLVA- 231
Query: 909 SLVGTPNYIAPEVLLRTG-------YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMK 961
VGTP+Y++PE+L G Y CDWW++GV +EM GQ PF A + ET K
Sbjct: 232 --VGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGK 289
Query: 962 VINWQTSLHIPPQAKLSP-EASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLR 1020
+++++ L +P + P EA D I +L PE RLG+ GA + + HPFF +D+ LR
Sbjct: 290 IVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDG-LR 348
Query: 1021 QQSASYIPKITHPTDTSNFDPVD 1043
+ P TDT NFD V+
Sbjct: 349 DSVPPFTPDFEGATDTCNFDLVE 371
>gi|126131093 myotonic dystrophy protein kinase isoform 3 [Homo
sapiens]
Length = 624
Score = 243 bits (619), Expect = 1e-63
Identities = 140/383 (36%), Positives = 208/383 (54%), Gaps = 57/383 (14%)
Query: 671 VGLSQDAQDQ-MRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKA 729
+G S+ AQD+ + L E +RLK ++ + F +K +G GAF EV + + T
Sbjct: 36 LGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQ 95
Query: 730 LYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGD 789
+YA K + K D+L R +V+ + ERD+L D W+ +L+++FQD++ LY VM+Y GGD
Sbjct: 96 VYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGD 155
Query: 790 MMSLLIRMG-IFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFG 848
+++LL + G P +ARFY+AE+ A++SVH++G++HRDIKPDNIL+DR GHI+L DFG
Sbjct: 156 LLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFG 215
Query: 849 LCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAH 908
C L+ RA + +A
Sbjct: 216 SC-------------------------------------------LKLRADGTVRSLVA- 231
Query: 909 SLVGTPNYIAPEVLLRTG-------YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMK 961
VGTP+Y++PE+L G Y CDWW++GV +EM GQ PF A + ET K
Sbjct: 232 --VGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGK 289
Query: 962 VINWQTSLHIPPQAKLSP-EASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLR 1020
+++++ L +P + P EA D I +L PE RLG+ GA + + HPFF +D+ LR
Sbjct: 290 IVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDG-LR 348
Query: 1021 QQSASYIPKITHPTDTSNFDPVD 1043
+ P TDT NFD V+
Sbjct: 349 DSVPPFTPDFEGATDTCNFDLVE 371
>gi|47059024 myotonic dystrophy protein kinase isoform 2 [Homo
sapiens]
Length = 629
Score = 243 bits (619), Expect = 1e-63
Identities = 140/383 (36%), Positives = 208/383 (54%), Gaps = 57/383 (14%)
Query: 671 VGLSQDAQDQ-MRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKA 729
+G S+ AQD+ + L E +RLK ++ + F +K +G GAF EV + + T
Sbjct: 36 LGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQ 95
Query: 730 LYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGD 789
+YA K + K D+L R +V+ + ERD+L D W+ +L+++FQD++ LY VM+Y GGD
Sbjct: 96 VYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGD 155
Query: 790 MMSLLIRMG-IFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFG 848
+++LL + G P +ARFY+AE+ A++SVH++G++HRDIKPDNIL+DR GHI+L DFG
Sbjct: 156 LLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFG 215
Query: 849 LCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAH 908
C L+ RA + +A
Sbjct: 216 SC-------------------------------------------LKLRADGTVRSLVA- 231
Query: 909 SLVGTPNYIAPEVLLRTG-------YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMK 961
VGTP+Y++PE+L G Y CDWW++GV +EM GQ PF A + ET K
Sbjct: 232 --VGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGK 289
Query: 962 VINWQTSLHIPPQAKLSP-EASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLR 1020
+++++ L +P + P EA D I +L PE RLG+ GA + + HPFF +D+ LR
Sbjct: 290 IVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDG-LR 348
Query: 1021 QQSASYIPKITHPTDTSNFDPVD 1043
+ P TDT NFD V+
Sbjct: 349 DSVPPFTPDFEGATDTCNFDLVE 371
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 240 bits (612), Expect = 6e-63
Identities = 142/368 (38%), Positives = 201/368 (54%), Gaps = 43/368 (11%)
Query: 697 RAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDI 756
R K +S F IK + GA+G V R +++ +A K + K++++LRNQ+ ERDI
Sbjct: 373 RRKPRESDFETIKLISNGAYGAVYFVRHKESRQRFAMKKINKQNLILRNQIQQAFVERDI 432
Query: 757 LAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAV 816
L A+N +VV +Y SF+ + +L VM+Y+ GGD +L+ MG P +AR Y AE A+
Sbjct: 433 LTFAENPFVVSMYCSFETRRHLCMVMEYVEGGDCATLMKNMGPLPVDMARMYFAETVLAL 492
Query: 817 ESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFS 876
E +H G +HRD+KPDN+L+ GHIKLTDFGL + + Y+ H +D+ +F
Sbjct: 493 EYLHNYGIVHRDLKPDNLLVTSMGHIKLTDFGLSKVGLMSMTTNLYEG--HIEKDAREF- 549
Query: 877 NEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSV 936
L + GTP YIAPEV+LR GY + DWW++
Sbjct: 550 -----------------------------LDKQVCGTPEYIAPEVILRQGYGKPVDWWAM 580
Query: 937 GVILFEMLVGQPPFLAQTPLETQMKV----INWQTSLHIPPQAKLSPEASDLIIKLCR-G 991
G+IL+E LVG PF TP E +V INW PP P+A DLI L R
Sbjct: 581 GIILYEFLVGCVPFFGDTPEELFGQVISDEINWPEKDEAPP-----PDAQDLITLLLRQN 635
Query: 992 PEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDD 1051
P +RLG GA E+K H FF+++D++S LRQ+ A +IP++ DTS FD +
Sbjct: 636 PLERLGTGGAYEVKQHRFFRSLDWNSLLRQK-AEFIPQLESEDDTSYFDTRSEKYHHMET 694
Query: 1052 NEEENVND 1059
EE++ ND
Sbjct: 695 EEEDDTND 702
Score = 33.1 bits (74), Expect = 1.5
Identities = 97/442 (21%), Positives = 163/442 (36%), Gaps = 105/442 (23%)
Query: 271 NSQTKRYSGNMEYVISR--ISPVPPGAWQEGYPPPPLNTSPMNP--------------PN 314
+++ K+ SG + +S +S + PG + + PL SPM+P P+
Sbjct: 884 STEKKKISGKVTKSLSASALSLMIPG---DMFAVSPLG-SPMSPHSLSSDPSSSRDSSPS 939
Query: 315 QGQRGISSVPVGRQPIIMQSSSK-------------------------FNFPSGRPGMQN 349
+ S+ P QPI++ SS K +N G P Q
Sbjct: 940 RDSSAASASP--HQPIVIHSSGKNYGFTIRAIRVYVGDSDIYTVHHIVWNVEEGSPACQA 997
Query: 350 GTGQTDFMIHQNVVPA-GTVNRQPPPPYPLTAANGQSPSALQTG--------GSAAPSSY 400
G D + H N P G V+ + L +G S T G A +SY
Sbjct: 998 GLKAGDLITHINGEPVHGLVHTEV---IELLLKSGNKVSITTTPFENTSIKTGPARRNSY 1054
Query: 401 TNGSIPQSMM------VPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIP-- 452
+ + +S + R S +L P L T+ S + S SSG +P
Sbjct: 1055 KSRMVRRSKKSKKKESLERRRSLFKKLAKQPSPLLHTS---RSFSCLNRSLSSGESLPGS 1111
Query: 453 ---TWQPNIPVRS--NSFNNPLGNRASHSANSQPSA------------TTVTAITPAPIQ 495
+ P P S ++ + P G +S S++ SA +T+ + P
Sbjct: 1112 PTHSLSPRSPTPSYRSTPDFPSGTNSSQSSSPSSSAPNSPAGSGHIRPSTLHGLAPKLGG 1171
Query: 496 QPVKSMRVLKPELQTALAPTH--PSWIPQPIQTVQ-PSPFPEGTASNVTVMPPVAEA-PN 551
Q +S R K L+P PS PQP + PSP + N +A+A P+
Sbjct: 1172 QRYRSGR-RKSAGNIPLSPLARTPSPTPQPTSPQRSPSPLLGHSLGN----SKIAQAFPS 1226
Query: 552 YQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENVDSGDKEKKQIT 611
PP +H++ + PP + K + ++ P +K K ++T
Sbjct: 1227 KMHSPPTIVRHIVRPKSAEPPRSPLLKRVQSEEKLSPSYGSDKKHL----CSRKHSLEVT 1282
Query: 612 TSPITVRKNKKDEERRESRIQS 633
+ ++++ +RE+ +QS
Sbjct: 1283 QEEV-----QREQSQREAPLQS 1299
Score = 30.8 bits (68), Expect = 7.6
Identities = 65/294 (22%), Positives = 99/294 (33%), Gaps = 33/294 (11%)
Query: 374 PPYPLTAANGQSPSALQTGGS----------AAPSSYTNGSIPQSMMVPNRNSHNMELYN 423
PP PLTA + SP+A Q S A PS+ S PQ P +H+ +
Sbjct: 1945 PPPPLTAKDLSSPAARQHCSSPSHASGREPGAKPSTAEPSSSPQDPPKPVA-AHSESSSH 2003
Query: 424 ISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSA 483
PG P + P +S S + + P + LG + S
Sbjct: 2004 KPRPGPDPG-PPKTKHPDRSLSSQKPSVGATKGKEPATQS-----LGGSSREGKGHSKSG 2057
Query: 484 TTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVM 543
V TP + + Q P+ P + +P P G V
Sbjct: 2058 PDVFPATPGSQNKASDGIG------QGEGGPSVPLHTDRAPLDAKPQPTSGGRPLEVLEK 2111
Query: 544 PPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSK-EDQPSLPKEDESEKSYENVDS 602
P P + GP P + L KPS +D P+L K+ ++ ++
Sbjct: 2112 PVHLPRPGHPGPSEPADQKLSAVGEKQTLSPKHPKPSTVKDCPTLCKQTDNRQT------ 2165
Query: 603 GDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQ 656
DK Q + + KK E + + +A F+ H EN LK ++
Sbjct: 2166 -DKSPSQPAANTDRRAEGKKCTEALYAPAEGDKLEAGLSFV--HSENRLKGAER 2216
>gi|126091095 myotonic dystrophy protein kinase isoform 1 [Homo
sapiens]
Length = 639
Score = 239 bits (610), Expect = 1e-62
Identities = 133/360 (36%), Positives = 197/360 (54%), Gaps = 56/360 (15%)
Query: 693 IRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKA 752
+RLK ++ + F +K +G GAF EV + + T +YA K + K D+L R +V+ +
Sbjct: 69 VRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE 128
Query: 753 ERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMG-IFPESLARFYIAE 811
ERD+L D W+ +L+++FQD++ LY VM+Y GGD+++LL + G P +ARFY+AE
Sbjct: 129 ERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAE 188
Query: 812 LTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQD 871
+ A++SVH++G++HRDIKPDNIL+DR GHI+L DFG C
Sbjct: 189 IVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSC--------------------- 227
Query: 872 SMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTG----- 926
L+ RA + +A VGTP+Y++PE+L G
Sbjct: 228 ----------------------LKLRADGTVRSLVA---VGTPDYLSPEILQAVGGGPGT 262
Query: 927 --YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSP-EASD 983
Y CDWW++GV +EM GQ PF A + ET K+++++ L +P + P EA D
Sbjct: 263 GSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARD 322
Query: 984 LIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVD 1043
I +L PE RLG+ GA + + HPFF +D+ LR + P TDT NFD V+
Sbjct: 323 FIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDG-LRDSVPPFTPDFEGATDTCNFDLVE 381
>gi|150170729 microtubule associated serine/threonine kinase 3 [Homo
sapiens]
Length = 1309
Score = 231 bits (590), Expect = 2e-60
Identities = 146/427 (34%), Positives = 223/427 (52%), Gaps = 40/427 (9%)
Query: 697 RAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDI 756
R K +S F IK + GA+G V L R DT+ +A K + K++++LRNQ+ V ERDI
Sbjct: 359 RRKPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDI 418
Query: 757 LAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAV 816
L A+N +VV ++ SF+ + +L VM+Y+ GGD +LL MG P +AR Y AE A+
Sbjct: 419 LTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLAL 478
Query: 817 ESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFS 876
E +H G +HRD+KPDN+LI GHIKLTDFGL + + Y+ H +D+ +F
Sbjct: 479 EYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEG--HIEKDAREFI 536
Query: 877 NEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSV 936
++ + GTP YIAPEV+ R GY + DWW++
Sbjct: 537 DK------------------------------QVCGTPEYIAPEVIFRQGYGKPVDWWAM 566
Query: 937 GVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCR-GPEDR 995
GV+L+E LVG PF TP E +V++ + +A L +A DLI +L R P DR
Sbjct: 567 GVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEA-LPADAQDLITRLLRQSPLDR 625
Query: 996 LGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEE 1055
LG G E+K HPFF +D++ LR + A ++P++ DTS FD ++ +E++
Sbjct: 626 LGTGGTHEVKQHPFFLALDWAGLLRHK-AEFVPQLEAEDDTSYFD-TRSERYRHLGSEDD 683
Query: 1056 NVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDD 1115
ND + + P+ + F + + + + P P E S+ E+ + +
Sbjct: 684 ETNDE----ESSTEIPQFSSCSHRFSKVYSSSEFLAVQPTPTFAERSFSEDREEGWERSE 739
Query: 1116 QNTGSEI 1122
+ G +
Sbjct: 740 VDYGRRL 746
Score = 32.0 bits (71), Expect = 3.4
Identities = 27/80 (33%), Positives = 35/80 (43%), Gaps = 8/80 (10%)
Query: 197 SVAYHSESPNSQTDVG--RPLSGSGISAFV-QAHPSNGQRVNP---PPPPQVRSVTPPPP 250
S + S SP S G RP S G++A + P G+R + PP P PP
Sbjct: 1139 SASPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPP 1198
Query: 251 PRGQTPPPRGTTPPPPSWEP 270
PR +P P PP P+ P
Sbjct: 1199 PRSPSPLP--GHPPAPARSP 1216
>gi|112363080 microtubule associated serine/threonine kinase 2 [Homo
sapiens]
Length = 1798
Score = 228 bits (581), Expect = 2e-59
Identities = 137/356 (38%), Positives = 193/356 (54%), Gaps = 35/356 (9%)
Query: 705 FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW 764
F IK + GA+G V L R T+ +A K + K++++LRNQ+ ERDIL A+N +
Sbjct: 512 FETIKLISNGAYGAVFLVRHKSTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF 571
Query: 765 VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGF 824
VV ++ SF K +L VM+Y+ GGD +LL +G P + R Y AE A+E +H G
Sbjct: 572 VVSMFCSFDTKRHLCMVMEYVEGGDCATLLKNIGALPVDMVRLYFAETVLALEYLHNYGI 631
Query: 825 IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSS 884
+HRD+KPDN+LI GHIKLTDFGL + + Y+ H +D+ +F
Sbjct: 632 VHRDLKPDNLLITSMGHIKLTDFGLSKIGLMSLTTNLYEG--HIEKDAREF--------- 680
Query: 885 CRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML 944
L + GTP YIAPEV+LR GY + DWW++G+IL+E L
Sbjct: 681 ---------------------LDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFL 719
Query: 945 VGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLC-RGPEDRLGKNGADE 1003
VG PF TP E +VI+ + +A L P+A DL KL + P +RLG A E
Sbjct: 720 VGCVPFFGDTPEELFGQVISDEIVWPEGDEA-LPPDAQDLTSKLLHQNPLERLGTGSAYE 778
Query: 1004 IKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVND 1059
+K HPFF +D++ LRQ+ A +IP++ DTS FD D +EE V++
Sbjct: 779 VKQHPFFTGLDWTGLLRQK-AEFIPQLESEDDTSYFDTRSERYHHMDSEDEEEVSE 833
>gi|4759050 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Homo
sapiens]
Length = 740
Score = 220 bits (560), Expect = 7e-57
Identities = 133/359 (37%), Positives = 199/359 (55%), Gaps = 59/359 (16%)
Query: 690 SNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKV---DTKALYATKTLRKKDVLLRNQ 746
+++++ K D S F +K LG G+FG+V L +K+ D + LYA K L+K + +R++
Sbjct: 53 THHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDR 112
Query: 747 VAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLAR 806
V K ERDIL E ++ ++V+L+Y+FQ + LY ++D++ GGD+ + L + +F E +
Sbjct: 113 V-RTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVK 171
Query: 807 FYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGD 866
FY+AEL A++ +H +G I+RD+KP+NIL+D +GHIKLTDFGL +S D
Sbjct: 172 FYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSK-----------ESID 220
Query: 867 HPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTG 926
H ++ A+S GT Y+APEV+ R G
Sbjct: 221 HEKK------------------------------------AYSFCGTVEYMAPEVVNRRG 244
Query: 927 YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLII 986
+TQ DWWS GV++FEML G PF + ET ++ + + PQ LSPEA L+
Sbjct: 245 HTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGM---PQF-LSPEAQSLLR 300
Query: 987 KLC-RGPEDRL--GKNGADEIKAHPFFKTIDFSSDLRQQ-SASYIPKITHPTDTSNFDP 1041
L R P +RL G +G +EIK H FF TID++ R++ + P P DT FDP
Sbjct: 301 MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDP 359
Score = 85.1 bits (209), Expect = 3e-16
Identities = 67/236 (28%), Positives = 101/236 (42%), Gaps = 47/236 (19%)
Query: 765 VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGF 824
++ L + D +Y V + + GG+++ ++R F E A + +T VE +H G
Sbjct: 476 IITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGV 535
Query: 825 IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSS 884
+HRD+KP NIL + +E G+P S
Sbjct: 536 VHRDLKPSNIL---------------------------------------YVDESGNPES 556
Query: 885 CRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML 944
R D + RA + L + T N++APEVL R GY CD WS+GV+L+ ML
Sbjct: 557 IRICDFGFAKQLRA----ENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTML 612
Query: 945 VGQPPFL---AQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCR-GPEDRL 996
G PF TP E ++ + + SL +S A DL+ K+ P RL
Sbjct: 613 TGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRL 668
>gi|45120119 microtubule associated serine/threonine kinase 1 [Homo
sapiens]
Length = 1570
Score = 219 bits (559), Expect = 9e-57
Identities = 131/338 (38%), Positives = 185/338 (54%), Gaps = 37/338 (10%)
Query: 705 FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW 764
F IK + GA+G V L R DT+ +A K + K++++LRNQ+ ERDIL A+N +
Sbjct: 374 FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPF 433
Query: 765 VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGF 824
VV ++ SF+ + +L VM+Y+ GGD +LL +G P +AR Y AE A+E +H G
Sbjct: 434 VVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGI 493
Query: 825 IHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSS 884
+HRD+KPDN+LI GHIKLTDFGL + + Y+ H +D+ +F
Sbjct: 494 VHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEG--HIEKDAREF--------- 542
Query: 885 CRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEML 944
L + GTP YIAPEV+LR GY + DWW++G+IL+E L
Sbjct: 543 ---------------------LDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFL 581
Query: 945 VGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIK--LCRGPEDRLGKNGAD 1002
VG PF TP E +VI+ + P + P + L+I L P RLG GA
Sbjct: 582 VGCVPFFGDTPEELFGQVIS--DDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAF 639
Query: 1003 EIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFD 1040
E+K H FF+ +D++ LRQ+ A +IP + DTS FD
Sbjct: 640 EVKQHSFFRDLDWTGLLRQK-AEFIPHLESEDDTSYFD 676
Score = 30.4 bits (67), Expect = 9.9
Identities = 32/124 (25%), Positives = 52/124 (41%), Gaps = 7/124 (5%)
Query: 336 SKFNFPSGRPG-MQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGS 394
S F+ PS G M T ++++ T P P PL G SP L + +
Sbjct: 10 SNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSSP--LDSPRN 67
Query: 395 AAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTW 454
+P++ + S S R L ++ G TN P S+ + + SS H++P +
Sbjct: 68 FSPNTPAHFSFASSRRADGRR---WSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLP-Y 123
Query: 455 QPNI 458
QP +
Sbjct: 124 QPTV 127
>gi|55743136 ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform
b [Homo sapiens]
Length = 741
Score = 218 bits (556), Expect = 2e-56
Identities = 134/359 (37%), Positives = 202/359 (56%), Gaps = 59/359 (16%)
Query: 690 SNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKV---DTKALYATKTLRKKDVLLRNQ 746
S++++ K D S F +K LG G++G+V L RKV D LYA K L+K + +R++
Sbjct: 52 SHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDR 111
Query: 747 VAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLAR 806
V K ERDILAE ++ ++V+L+Y+FQ + LY ++D++ GGD+ + L + +F E +
Sbjct: 112 VRS-KMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVK 170
Query: 807 FYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGD 866
FY+AEL A++ +H +G I+RD+KP+NIL+D +GHIK+TDFGL ++ D
Sbjct: 171 FYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSK-----------EAID 219
Query: 867 HPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTG 926
H ++ A+S GT Y+APEV+ R G
Sbjct: 220 HDKR------------------------------------AYSFCGTIEYMAPEVVNRRG 243
Query: 927 YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLII 986
+TQ DWWS GV++FEML G PF + ET ++ + + PQ LS EA L+
Sbjct: 244 HTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGM---PQF-LSGEAQSLLR 299
Query: 987 KLC-RGPEDRLGK--NGADEIKAHPFFKTIDFSSDLRQQ-SASYIPKITHPTDTSNFDP 1041
L R P +RLG +G +EIK HPFF TID+++ R++ + P + P DT +FDP
Sbjct: 300 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDP 358
Score = 87.0 bits (214), Expect = 9e-17
Identities = 78/313 (24%), Positives = 134/313 (42%), Gaps = 60/313 (19%)
Query: 711 LGIGAFG--EVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRL 768
+G+G++ + C+ + DT+ YA K + K R+ ++ +L + ++ L
Sbjct: 429 IGVGSYSVCKRCVHKATDTE--YAVKIIDKSK---RDPSEEIEI---LLRYGQHPNIITL 480
Query: 769 YYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRD 828
+ D +Y VM+ + GG+++ ++R F E A + +T ++ +H G +HRD
Sbjct: 481 KDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRD 540
Query: 829 IKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCG 888
+KP NIL + +E G P S R
Sbjct: 541 LKPSNIL---------------------------------------YRDESGSPESIRVC 561
Query: 889 DRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQP 948
D + RA L + T N++APEVL R GY CD WS+G++L+ ML G
Sbjct: 562 DFGFAKQLRAGNG----LLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFT 617
Query: 949 PFL---AQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCR-GPEDRLGKNGADEI 1004
PF TP E ++ + + +L +S A D++ K+ P RL A ++
Sbjct: 618 PFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRL---TAMQV 674
Query: 1005 KAHPFFKTIDFSS 1017
HP+ ++ S
Sbjct: 675 LKHPWVVNREYLS 687
>gi|19923570 ribosomal protein S6 kinase, 90kDa, polypeptide 2 isoform
a [Homo sapiens]
Length = 733
Score = 218 bits (556), Expect = 2e-56
Identities = 134/359 (37%), Positives = 202/359 (56%), Gaps = 59/359 (16%)
Query: 690 SNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKV---DTKALYATKTLRKKDVLLRNQ 746
S++++ K D S F +K LG G++G+V L RKV D LYA K L+K + +R++
Sbjct: 44 SHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDR 103
Query: 747 VAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLAR 806
V K ERDILAE ++ ++V+L+Y+FQ + LY ++D++ GGD+ + L + +F E +
Sbjct: 104 VRS-KMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVK 162
Query: 807 FYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGD 866
FY+AEL A++ +H +G I+RD+KP+NIL+D +GHIK+TDFGL ++ D
Sbjct: 163 FYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSK-----------EAID 211
Query: 867 HPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTG 926
H ++ A+S GT Y+APEV+ R G
Sbjct: 212 HDKR------------------------------------AYSFCGTIEYMAPEVVNRRG 235
Query: 927 YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLII 986
+TQ DWWS GV++FEML G PF + ET ++ + + PQ LS EA L+
Sbjct: 236 HTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGM---PQF-LSGEAQSLLR 291
Query: 987 KLC-RGPEDRLGK--NGADEIKAHPFFKTIDFSSDLRQQ-SASYIPKITHPTDTSNFDP 1041
L R P +RLG +G +EIK HPFF TID+++ R++ + P + P DT +FDP
Sbjct: 292 ALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDP 350
Score = 87.0 bits (214), Expect = 9e-17
Identities = 78/313 (24%), Positives = 134/313 (42%), Gaps = 60/313 (19%)
Query: 711 LGIGAFG--EVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRL 768
+G+G++ + C+ + DT+ YA K + K R+ ++ +L + ++ L
Sbjct: 421 IGVGSYSVCKRCVHKATDTE--YAVKIIDKSK---RDPSEEIEI---LLRYGQHPNIITL 472
Query: 769 YYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRD 828
+ D +Y VM+ + GG+++ ++R F E A + +T ++ +H G +HRD
Sbjct: 473 KDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRD 532
Query: 829 IKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCG 888
+KP NIL + +E G P S R
Sbjct: 533 LKPSNIL---------------------------------------YRDESGSPESIRVC 553
Query: 889 DRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQP 948
D + RA L + T N++APEVL R GY CD WS+G++L+ ML G
Sbjct: 554 DFGFAKQLRAGNG----LLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFT 609
Query: 949 PFL---AQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCR-GPEDRLGKNGADEI 1004
PF TP E ++ + + +L +S A D++ K+ P RL A ++
Sbjct: 610 PFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRL---TAMQV 666
Query: 1005 KAHPFFKTIDFSS 1017
HP+ ++ S
Sbjct: 667 LKHPWVVNREYLS 679
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 216 bits (550), Expect = 1e-55
Identities = 130/345 (37%), Positives = 188/345 (54%), Gaps = 63/345 (18%)
Query: 711 LGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYY 770
+G G F EV + R+ T +YA K ++KK +L + QV+ + ER+IL+ + + W+ +L Y
Sbjct: 103 VGCGHFAEVQVVREKATGDIYAMKVMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQY 162
Query: 771 SFQDKDNLYFVMDYIPGGDMMSLLIRM-GIFPESLARFYIAELTCAVESVHKMGFIHRDI 829
+FQDK++LY VM+Y PGGD++SLL R E+L +FY+AEL AV SVH MG++HRDI
Sbjct: 163 AFQDKNHLYLVMEYQPGGDLLSLLNRYEDQLDENLIQFYLAELILAVHSVHLMGYVHRDI 222
Query: 830 KPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGD 889
KP+NIL+DR GHIKL DFG
Sbjct: 223 KPENILVDRTGHIKLVDFG----------------------------------------- 241
Query: 890 RLKPLERRAARQHQRCLAHSL--VGTPNYIAPEVLL------RTGYTQLCDWWSVGVILF 941
AA+ + + ++ +GTP+Y+APEVL + Y CDWWSVGVI +
Sbjct: 242 -------SAAKMNSNKMVNAKLPIGTPDYMAPEVLTVMNGDGKGTYGLDCDWWSVGVIAY 294
Query: 942 EMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGA 1001
EM+ G+ PF T T ++N+Q L P K+S + DLI L G ++RL G
Sbjct: 295 EMIYGRSPFAEGTSARTFNNIMNFQRFLKFPDDPKVSSDFLDLIQSLLCGQKERLKFEG- 353
Query: 1002 DEIKAHPFFKTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDK 1046
+ HPFF ID+ +++R ++P + DTSNFD +P+K
Sbjct: 354 --LCCHPFFSKIDW-NNIRNSPPPFVPTLKSDDDTSNFD--EPEK 393
>gi|55743134 ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform
b [Homo sapiens]
Length = 744
Score = 211 bits (538), Expect = 2e-54
Identities = 130/358 (36%), Positives = 198/358 (55%), Gaps = 59/358 (16%)
Query: 690 SNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKV---DTKALYATKTLRKKDVLLRNQ 746
+++++ K D S F +K LG G+FG+V L RKV D+ LYA K L+K + +R++
Sbjct: 56 THHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDR 115
Query: 747 VAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLAR 806
V K ERDILA+ ++ +VV+L+Y+FQ + LY ++D++ GGD+ + L + +F E +
Sbjct: 116 V-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVK 174
Query: 807 FYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGD 866
FY+AEL ++ +H +G I+RD+KP+NIL+D +GHIKLTDFGL ++ D
Sbjct: 175 FYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSK-----------EAID 223
Query: 867 HPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTG 926
H ++ A+S GT Y+APEV+ R G
Sbjct: 224 HEKK------------------------------------AYSFCGTVEYMAPEVVNRQG 247
Query: 927 YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLII 986
++ DWWS GV++FEML G PF + ET ++ + + PQ LS EA L+
Sbjct: 248 HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGM---PQF-LSTEAQSLLR 303
Query: 987 KLC-RGPEDRLGK--NGADEIKAHPFFKTIDFSSDLRQQ-SASYIPKITHPTDTSNFD 1040
L R P +RLG +GA+EIK H F+ TID++ R++ + P + P DT FD
Sbjct: 304 ALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFD 361
Score = 92.8 bits (229), Expect = 2e-18
Identities = 79/317 (24%), Positives = 134/317 (42%), Gaps = 72/317 (22%)
Query: 705 FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW 764
+V +T+G+G++ E T YA K + K R+ ++ +L +
Sbjct: 427 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSK---RDPSEEIEI---LLRYGQHPN 480
Query: 765 VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGF 824
++ L + D ++Y V + + GG+++ ++R F E A F + + VE +H G
Sbjct: 481 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGV 540
Query: 825 IHRDIKPDNIL-IDRDGH---IKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWG 880
+HRD+KP NIL +D G+ +++ DFG R
Sbjct: 541 VHRDLKPSNILYVDESGNPECLRICDFGFAKQLR-------------------------- 574
Query: 881 DPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTP----NYIAPEVLLRTGYTQLCDWWSV 936
+ L+ TP N++APEVL R GY + CD WS+
Sbjct: 575 -------------------------AENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSL 609
Query: 937 GVILFEMLVGQPPFL---AQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCR-GP 992
G++L+ ML G PF + TP E ++ + + +L +S A DL+ K+ P
Sbjct: 610 GILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 669
Query: 993 EDRLGKNGADEIKAHPF 1009
RL A ++ HP+
Sbjct: 670 HQRL---TAKQVLQHPW 683
>gi|20149547 ribosomal protein S6 kinase, 90kDa, polypeptide 1 isoform
a [Homo sapiens]
Length = 735
Score = 211 bits (538), Expect = 2e-54
Identities = 130/358 (36%), Positives = 198/358 (55%), Gaps = 59/358 (16%)
Query: 690 SNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKV---DTKALYATKTLRKKDVLLRNQ 746
+++++ K D S F +K LG G+FG+V L RKV D+ LYA K L+K + +R++
Sbjct: 47 THHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDR 106
Query: 747 VAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLAR 806
V K ERDILA+ ++ +VV+L+Y+FQ + LY ++D++ GGD+ + L + +F E +
Sbjct: 107 V-RTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVK 165
Query: 807 FYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGD 866
FY+AEL ++ +H +G I+RD+KP+NIL+D +GHIKLTDFGL ++ D
Sbjct: 166 FYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSK-----------EAID 214
Query: 867 HPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTG 926
H ++ A+S GT Y+APEV+ R G
Sbjct: 215 HEKK------------------------------------AYSFCGTVEYMAPEVVNRQG 238
Query: 927 YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLII 986
++ DWWS GV++FEML G PF + ET ++ + + PQ LS EA L+
Sbjct: 239 HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGM---PQF-LSTEAQSLLR 294
Query: 987 KLC-RGPEDRLGK--NGADEIKAHPFFKTIDFSSDLRQQ-SASYIPKITHPTDTSNFD 1040
L R P +RLG +GA+EIK H F+ TID++ R++ + P + P DT FD
Sbjct: 295 ALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAVAQPDDTFYFD 352
Score = 92.8 bits (229), Expect = 2e-18
Identities = 79/317 (24%), Positives = 134/317 (42%), Gaps = 72/317 (22%)
Query: 705 FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW 764
+V +T+G+G++ E T YA K + K R+ ++ +L +
Sbjct: 418 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSK---RDPSEEIEI---LLRYGQHPN 471
Query: 765 VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGF 824
++ L + D ++Y V + + GG+++ ++R F E A F + + VE +H G
Sbjct: 472 IITLKDVYDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGV 531
Query: 825 IHRDIKPDNIL-IDRDGH---IKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWG 880
+HRD+KP NIL +D G+ +++ DFG R
Sbjct: 532 VHRDLKPSNILYVDESGNPECLRICDFGFAKQLR-------------------------- 565
Query: 881 DPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTP----NYIAPEVLLRTGYTQLCDWWSV 936
+ L+ TP N++APEVL R GY + CD WS+
Sbjct: 566 -------------------------AENGLLMTPCYTANFVAPEVLKRQGYDEGCDIWSL 600
Query: 937 GVILFEMLVGQPPFL---AQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCR-GP 992
G++L+ ML G PF + TP E ++ + + +L +S A DL+ K+ P
Sbjct: 601 GILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKMLHVDP 660
Query: 993 EDRLGKNGADEIKAHPF 1009
RL A ++ HP+
Sbjct: 661 HQRL---TAKQVLQHPW 674
>gi|4506055 cAMP-dependent protein kinase catalytic subunit alpha
isoform 1 [Homo sapiens]
Length = 351
Score = 211 bits (536), Expect = 4e-54
Identities = 132/401 (32%), Positives = 204/401 (50%), Gaps = 72/401 (17%)
Query: 661 KKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVC 720
KK E E ++ L++ +D ++K ++ A +D+ F +IKTLG G+FG V
Sbjct: 8 KKGSEQESVKEFLAKAKEDFLKKWESPAQNT------AHLDQ--FERIKTLGTGSFGRVM 59
Query: 721 LARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF 780
L + +T YA K L K+ V+ Q+ H E+ IL + ++V+L +SF+D NLY
Sbjct: 60 LVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYM 119
Query: 781 VMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDG 840
VM+Y+PGG+M S L R+G F E ARFY A++ E +H + I+RD+KP+N+LID+ G
Sbjct: 120 VMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG 179
Query: 841 HIKLTDFGLC---TGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERR 897
+I++TDFG G WT
Sbjct: 180 YIQVTDFGFAKRVKGRTWT----------------------------------------- 198
Query: 898 AARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLE 957
L GTP Y+APE++L GY + DWW++GV+++EM G PPF A P++
Sbjct: 199 ------------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ 246
Query: 958 TQMKVINWQTSLHIPPQAKLSPEASDLIIKLCR-GPEDRLG--KNGADEIKAHPFFKTID 1014
K+++ + + S + DL+ L + R G KNG ++IK H +F T D
Sbjct: 247 IYEKIVSGKVRF----PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTD 302
Query: 1015 FSSDL-RQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEE 1054
+ + R+ A +IPK P DTSNFD + +++ NE+
Sbjct: 303 WIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEK 343
>gi|15619015 protein kinase, cAMP-dependent, catalytic, gamma [Homo
sapiens]
Length = 351
Score = 208 bits (529), Expect = 3e-53
Identities = 123/357 (34%), Positives = 186/357 (52%), Gaps = 64/357 (17%)
Query: 705 FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW 764
F +++TLG+G+FG V L R +T YA K L K+ V+ QV H+ E+ IL D +
Sbjct: 44 FERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPF 103
Query: 765 VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGF 824
+V+L +SF+D LY VM+Y+PGG+M S L R+G F E A FY A++ AV+ +H +
Sbjct: 104 LVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDL 163
Query: 825 IHRDIKPDNILIDRDGHIKLTDFGLC---TGFRWTHDSKYYQSGDHPRQDSMDFSNEWGD 881
IHRD+KP+N+LID+ G++++TDFG G WT
Sbjct: 164 IHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWT------------------------- 198
Query: 882 PSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILF 941
L GTP Y+APE++L GY + DWW++GV+++
Sbjct: 199 ----------------------------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIY 230
Query: 942 EMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCR-GPEDRLG--K 998
EM VG PPF A P++ K+++ + +KLS + L+ L + R G +
Sbjct: 231 EMAVGFPPFYADQPIQIYEKIVSGRVRF----PSKLSSDLKHLLRSLLQVDLTKRFGNLR 286
Query: 999 NGADEIKAHPFFKTIDFSSDLRQQ-SASYIPKITHPTDTSNFDPVDPDKLWSDDNEE 1054
NG +IK H +F T + + ++ A +IPK T P D SNFD + ++L NE+
Sbjct: 287 NGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEK 343
>gi|46909584 cAMP-dependent protein kinase catalytic subunit alpha
isoform 2 [Homo sapiens]
Length = 343
Score = 207 bits (528), Expect = 3e-53
Identities = 123/357 (34%), Positives = 184/357 (51%), Gaps = 64/357 (17%)
Query: 705 FVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEW 764
F +IKTLG G+FG V L + +T YA K L K+ V+ Q+ H E+ IL + +
Sbjct: 36 FERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 95
Query: 765 VVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGF 824
+V+L +SF+D NLY VM+Y+PGG+M S L R+G F E ARFY A++ E +H +
Sbjct: 96 LVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL 155
Query: 825 IHRDIKPDNILIDRDGHIKLTDFGLC---TGFRWTHDSKYYQSGDHPRQDSMDFSNEWGD 881
I+RD+KP+N+LID+ G+I++TDFG G WT
Sbjct: 156 IYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWT------------------------- 190
Query: 882 PSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILF 941
L GTP Y+APE++L GY + DWW++GV+++
Sbjct: 191 ----------------------------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIY 222
Query: 942 EMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCR-GPEDRLG--K 998
EM G PPF A P++ K+++ + + S + DL+ L + R G K
Sbjct: 223 EMAAGYPPFFADQPIQIYEKIVSGKVRF----PSHFSSDLKDLLRNLLQVDLTKRFGNLK 278
Query: 999 NGADEIKAHPFFKTIDFSSDL-RQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEE 1054
NG ++IK H +F T D+ + R+ A +IPK P DTSNFD + +++ NE+
Sbjct: 279 NGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEK 335
>gi|7657526 ribosomal protein S6 kinase polypeptide 6 [Homo sapiens]
Length = 745
Score = 207 bits (527), Expect = 5e-53
Identities = 129/357 (36%), Positives = 192/357 (53%), Gaps = 57/357 (15%)
Query: 690 SNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKV---DTKALYATKTLRKKDVLLRNQ 746
+++++ K D + F +K LG G+FG+V L RK D LYA K L+K + +R++
Sbjct: 58 THHVKEGYEKADPAQFELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKASLKVRDR 117
Query: 747 VAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLAR 806
V K ERDIL E ++ ++V+L+Y+FQ + LY ++D++ GGD+ + L + +F E +
Sbjct: 118 V-RTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDVFTRLSKEVLFTEEDVK 176
Query: 807 FYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWTHDSKYYQSGD 866
FY+AEL A++ +H++G ++RD+KP+NIL+D GHIKLTDFGL
Sbjct: 177 FYLAELALALDHLHQLGIVYRDLKPENILLDEIGHIKLTDFGL----------------- 219
Query: 867 HPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTG 926
++S+D Q A+S GT Y+APEV+ R G
Sbjct: 220 --SKESVD----------------------------QEKKAYSFCGTVEYMAPEVVNRRG 249
Query: 927 YTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIPPQAKLSPEASDLII 986
++Q DWWS GV++FEML G PF + ET ++ + + PQ LS EA L+
Sbjct: 250 HSQSADWWSYGVLMFEMLTGTLPFQGKDRNETMNMILKAKLGM---PQF-LSAEAQSLLR 305
Query: 987 KLC-RGPEDRLGKNGADEIKAHPFFKTIDFSS-DLRQQSASYIPKITHPTDTSNFDP 1041
L R P +RLG G +EIK H FF ID+ R+ + P P DT FDP
Sbjct: 306 MLFKRNPANRLGSEGVEEIKRHLFFANIDWDKLYKREVQPPFKPASGKPDDTFCFDP 362
Score = 77.8 bits (190), Expect = 5e-14
Identities = 82/356 (23%), Positives = 138/356 (38%), Gaps = 75/356 (21%)
Query: 711 LGIGAFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAE-ADNEWVVRLY 769
+G+G++ VC + ++AT + ++ E +IL + ++ L
Sbjct: 432 IGVGSYS-VC------KRCIHATTNMEFAVKIIDKSKRDPSEEIEILMRYGQHPNIITLK 484
Query: 770 YSFQDKDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDI 829
F D +Y V D + GG+++ +++ F E A + ++ V+ +H G +HRD+
Sbjct: 485 DVFDDGRYVYLVTDLMKGGELLDRILKQKCFSEREASDILYVISKTVDYLHCQGVVHRDL 544
Query: 830 KPDNILIDRDG----HIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSC 885
KP NIL + I++ DFG R +
Sbjct: 545 KPSNILYMDESASADSIRICDFGFAKQLRGEN---------------------------- 576
Query: 886 RCGDRLKPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLV 945
G L P T N++APEVL++ GY CD WS+GV+ + ML
Sbjct: 577 --GLLLTPCY-----------------TANFVAPEVLMQQGYDAACDIWSLGVLFYTMLA 617
Query: 946 GQPPFL---AQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGAD 1002
G PF TP E +++ N + SL +S A DL+ + D + A+
Sbjct: 618 GYTPFANGPNDTPEEILLRIGNGKFSLSGGNWDNISDGAKDLLSHMLH--MDPHQRYTAE 675
Query: 1003 EIKAHPFF-----------KTIDFSSDLRQQSASYIPKITHPTDTSNFDPVDPDKL 1047
+I H + K D S ++ + +TH T +PV L
Sbjct: 676 QILKHSWITHRDQLPNDQPKRNDVSHVVKGAMVATYSALTHKTFQPVLEPVAASSL 731
>gi|33636738 cAMP-dependent protein kinase catalytic subunit beta
isoform 1 [Homo sapiens]
Length = 398
Score = 203 bits (516), Expect = 9e-52
Identities = 127/400 (31%), Positives = 196/400 (49%), Gaps = 69/400 (17%)
Query: 660 RKKQLENEMMRVGLSQDAQDQ-MRKMLCQKESNYIRLKRAKMDKSM----FVKIKTLGIG 714
+K LEN+ + D+ M++ L + + ++++ + F + KTLG G
Sbjct: 41 QKTALENDSLHFSEHTALWDRSMKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTG 100
Query: 715 AFGEVCLARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQD 774
+FG V L + T+ YA K L K+ V+ Q+ H E+ IL + ++VRL Y+F+D
Sbjct: 101 SFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKD 160
Query: 775 KDNLYFVMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNI 834
NLY VM+Y+PGG+M S L R+G F E ARFY A++ E +H + I+RD+KP+N+
Sbjct: 161 NSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENL 220
Query: 835 LIDRDGHIKLTDFGLC---TGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRL 891
LID G+I++TDFG G WT
Sbjct: 221 LIDHQGYIQVTDFGFAKRVKGRTWT----------------------------------- 245
Query: 892 KPLERRAARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFL 951
L GTP Y+APE++L GY + DWW++GV+++EM G PPF
Sbjct: 246 ------------------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF 287
Query: 952 AQTPLETQMKVINWQTSLHIPPQAKLSPEASDLIIKLCR-GPEDRLG--KNGADEIKAHP 1008
A P++ K+++ + + S + DL+ L + R G KNG +IK H
Sbjct: 288 ADQPIQIYEKIVSGKVRF----PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHK 343
Query: 1009 FFKTIDFSSDL-RQQSASYIPKITHPTDTSNFDPVDPDKL 1047
+F T D+ + R+ A +IPK DTSNFD + + +
Sbjct: 344 WFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDI 383
>gi|4506057 cAMP-dependent protein kinase catalytic subunit beta
isoform 2 [Homo sapiens]
Length = 351
Score = 202 bits (515), Expect = 1e-51
Identities = 129/394 (32%), Positives = 196/394 (49%), Gaps = 72/394 (18%)
Query: 661 KKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVC 720
KK E E ++ L++ +D ++K ++N A ++ F + KTLG G+FG V
Sbjct: 8 KKGSEVESVKEFLAKAKEDFLKKWENPTQNN------AGLED--FERKKTLGTGSFGRVM 59
Query: 721 LARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF 780
L + T+ YA K L K+ V+ Q+ H E+ IL + ++VRL Y+F+D NLY
Sbjct: 60 LVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYM 119
Query: 781 VMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDG 840
VM+Y+PGG+M S L R+G F E ARFY A++ E +H + I+RD+KP+N+LID G
Sbjct: 120 VMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQG 179
Query: 841 HIKLTDFGLC---TGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERR 897
+I++TDFG G WT
Sbjct: 180 YIQVTDFGFAKRVKGRTWT----------------------------------------- 198
Query: 898 AARQHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLE 957
L GTP Y+APE++L GY + DWW++GV+++EM G PPF A P++
Sbjct: 199 ------------LCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQ 246
Query: 958 TQMKVINWQTSLHIPPQAKLSPEASDLIIKLCR-GPEDRLG--KNGADEIKAHPFFKTID 1014
K+++ + + S + DL+ L + R G KNG +IK H +F T D
Sbjct: 247 IYEKIVSGKVRF----PSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 302
Query: 1015 FSSDL-RQQSASYIPKITHPTDTSNFDPVDPDKL 1047
+ + R+ A +IPK DTSNFD + + +
Sbjct: 303 WIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDI 336
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,857,979
Number of Sequences: 37866
Number of extensions: 3385245
Number of successful extensions: 35752
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 985
Number of HSP's successfully gapped in prelim test: 1274
Number of HSP's that attempted gapping in prelim test: 16000
Number of HSP's gapped (non-prelim): 10866
length of query: 1130
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1017
effective length of database: 13,968,660
effective search space: 14206127220
effective search space used: 14206127220
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.