BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|47578107 delangin isoform B [Homo sapiens] (2697 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|47578107 delangin isoform B [Homo sapiens] 5329 0.0 gi|47578105 delangin isoform A [Homo sapiens] 5306 0.0 gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 100 3e-20 gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 99 6e-20 gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 87 2e-16 gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 82 9e-15 gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 82 9e-15 gi|87299628 biorientation of chromosomes in cell division 1-like... 81 1e-14 gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 81 1e-14 gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 80 2e-14 gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 79 5e-14 gi|6631100 natural killer-tumor recognition sequence [Homo sapiens] 78 1e-13 gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 77 3e-13 gi|217330641 IWS1 homolog [Homo sapiens] 74 1e-12 gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 74 3e-12 gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens] 73 3e-12 gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 73 4e-12 gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 73 4e-12 gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 73 4e-12 gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 73 4e-12 gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 72 6e-12 gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 72 6e-12 gi|104526627 triadin [Homo sapiens] 72 7e-12 gi|148746195 trichohyalin [Homo sapiens] 72 1e-11 gi|150170670 piccolo isoform 2 [Homo sapiens] 72 1e-11 gi|150378539 piccolo isoform 1 [Homo sapiens] 72 1e-11 gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 69 8e-11 gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 69 8e-11 gi|117676384 splicing factor, arginine/serine-rich 2, interactin... 68 1e-10 gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 68 1e-10 >gi|47578107 delangin isoform B [Homo sapiens] Length = 2697 Score = 5329 bits (13823), Expect = 0.0 Identities = 2697/2697 (100%), Positives = 2697/2697 (100%) Query: 1 MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDN 60 MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDN Sbjct: 1 MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDN 60 Query: 61 LVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSG 120 LVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSG Sbjct: 61 LVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSG 120 Query: 121 MMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP 180 MMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP Sbjct: 121 MMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP 180 Query: 181 QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPR 240 QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPR Sbjct: 181 QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPR 240 Query: 241 HGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQ 300 HGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQ Sbjct: 241 HGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQ 300 Query: 301 SLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL 360 SLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL Sbjct: 301 SLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL 360 Query: 361 RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCL 420 RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCL Sbjct: 361 RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCL 420 Query: 421 SQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI 480 SQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI Sbjct: 421 SQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI 480 Query: 481 ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540 ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM Sbjct: 481 ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540 Query: 541 VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600 VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP Sbjct: 541 VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600 Query: 601 KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660 KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE Sbjct: 601 KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660 Query: 661 CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG 720 CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG Sbjct: 661 CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG 720 Query: 721 HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS 780 HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS Sbjct: 721 HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS 780 Query: 781 KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV 840 KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV Sbjct: 781 KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV 840 Query: 841 RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900 RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS Sbjct: 841 RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900 Query: 901 NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK 960 NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK Sbjct: 901 NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK 960 Query: 961 IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR 1020 IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR Sbjct: 961 IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR 1020 Query: 1021 EDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN 1080 EDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN Sbjct: 1021 EDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN 1080 Query: 1081 EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRS 1140 EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRS Sbjct: 1081 EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRS 1140 Query: 1141 SGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200 SGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK Sbjct: 1141 SGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200 Query: 1201 RFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD 1260 RFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD Sbjct: 1201 RFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD 1260 Query: 1261 KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTS 1320 KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTS Sbjct: 1261 KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTS 1320 Query: 1321 PNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQ 1380 PNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQ Sbjct: 1321 PNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQ 1380 Query: 1381 RVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA 1440 RVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA Sbjct: 1381 RVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA 1440 Query: 1441 VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQC 1500 VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQC Sbjct: 1441 VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQC 1500 Query: 1501 VVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRP 1560 VVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRP Sbjct: 1501 VVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRP 1560 Query: 1561 LFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL 1620 LFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL Sbjct: 1561 LFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL 1620 Query: 1621 RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQW 1680 RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQW Sbjct: 1621 RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQW 1680 Query: 1681 FRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFST 1740 FRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFST Sbjct: 1681 FRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFST 1740 Query: 1741 LKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV 1800 LKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV Sbjct: 1741 LKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV 1800 Query: 1801 AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDT 1860 AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDT Sbjct: 1801 AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDT 1860 Query: 1861 GISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPH 1920 GISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPH Sbjct: 1861 GISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPH 1920 Query: 1921 NDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE 1980 NDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE Sbjct: 1921 NDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE 1980 Query: 1981 HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQND 2040 HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQND Sbjct: 1981 HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQND 2040 Query: 2041 FMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVT 2100 FMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVT Sbjct: 2041 FMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVT 2100 Query: 2101 QNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED 2160 QNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED Sbjct: 2101 QNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED 2160 Query: 2161 FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNIL 2220 FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNIL Sbjct: 2161 FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNIL 2220 Query: 2221 SDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQ 2280 SDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQ Sbjct: 2221 SDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQ 2280 Query: 2281 LYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ 2340 LYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ Sbjct: 2281 LYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ 2340 Query: 2341 QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIR 2400 QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIR Sbjct: 2341 QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIR 2400 Query: 2401 GNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVS 2460 GNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVS Sbjct: 2401 GNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVS 2460 Query: 2461 GSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN 2520 GSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN Sbjct: 2461 GSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN 2520 Query: 2521 SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAI 2580 SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAI Sbjct: 2521 SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAI 2580 Query: 2581 NRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVS 2640 NRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVS Sbjct: 2581 NRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVS 2640 Query: 2641 ASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGVRRRRSQRISQRIT 2697 ASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGVRRRRSQRISQRIT Sbjct: 2641 ASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGVRRRRSQRISQRIT 2697 >gi|47578105 delangin isoform A [Homo sapiens] Length = 2804 Score = 5306 bits (13764), Expect = 0.0 Identities = 2685/2687 (99%), Positives = 2685/2687 (99%) Query: 1 MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDN 60 MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDN Sbjct: 1 MNGDMPHVPITTLAGIASLTDLLNQLPLPSPLPATTTKSLLFNARIAEEVNCLLACRDDN 60 Query: 61 LVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSG 120 LVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSG Sbjct: 61 LVSQLVHSLNQVSTDHIELKDNLGSDDPEGDIPVLLQAVLARSPNVFREKSMQNRYVQSG 120 Query: 121 MMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP 180 MMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP Sbjct: 121 MMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAP 180 Query: 181 QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPR 240 QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPR Sbjct: 181 QSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPR 240 Query: 241 HGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQ 300 HGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQ Sbjct: 241 HGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQ 300 Query: 301 SLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL 360 SLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL Sbjct: 301 SLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTL 360 Query: 361 RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCL 420 RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCL Sbjct: 361 RLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCL 420 Query: 421 SQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI 480 SQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI Sbjct: 421 SQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI 480 Query: 481 ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540 ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM Sbjct: 481 ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540 Query: 541 VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600 VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP Sbjct: 541 VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600 Query: 601 KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660 KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE Sbjct: 601 KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660 Query: 661 CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG 720 CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG Sbjct: 661 CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG 720 Query: 721 HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS 780 HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS Sbjct: 721 HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS 780 Query: 781 KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV 840 KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV Sbjct: 781 KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV 840 Query: 841 RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900 RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS Sbjct: 841 RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900 Query: 901 NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK 960 NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK Sbjct: 901 NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK 960 Query: 961 IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR 1020 IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR Sbjct: 961 IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR 1020 Query: 1021 EDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN 1080 EDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN Sbjct: 1021 EDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVN 1080 Query: 1081 EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRS 1140 EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRS Sbjct: 1081 EKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRS 1140 Query: 1141 SGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200 SGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK Sbjct: 1141 SGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200 Query: 1201 RFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD 1260 RFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD Sbjct: 1201 RFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMGIMDKLSTD 1260 Query: 1261 KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTS 1320 KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTS Sbjct: 1261 KTVKVLNILEKNIQDGSKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTS 1320 Query: 1321 PNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQ 1380 PNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQ Sbjct: 1321 PNMPKAVYIEDVIERVIQYTKFHLQNTLYPQYDPVYRLDPHGGGLLSSKAKRAKCSTHKQ 1380 Query: 1381 RVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA 1440 RVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA Sbjct: 1381 RVIVMLYNKVCDIVSSLSELLEIQLLTDTTILQVSSMGITPFFVENVSELQLCAIKLVTA 1440 Query: 1441 VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQC 1500 VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQC Sbjct: 1441 VFSRYEKHRQLILEEIFTSLARLPTSKRSLRNFRLNSSDMDGEPMYIQMVTALVLQLIQC 1500 Query: 1501 VVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRP 1560 VVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRP Sbjct: 1501 VVHLPSSEKDSNAEEDSNKKIDQDVVITNSYETAMRTAQNFLSIFLKKCGSKQGEEDYRP 1560 Query: 1561 LFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL 1620 LFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL Sbjct: 1561 LFENFVQDLLSTVNKPEWPAAELLLSLLGRLLVHQFSNKSTEMALRVASLDYLGTVAARL 1620 Query: 1621 RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQW 1680 RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQW Sbjct: 1621 RKDAVTSKMDQGSIERILKQVSGGEDEIQQLQKALLDYLDENTETDPSLVFSRKFYIAQW 1680 Query: 1681 FRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFST 1740 FRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFST Sbjct: 1681 FRDTTLETEKAMKSQKDEESSEGTHHAKEIETTGQIMHRAENRKKFLRSIIKTTPSQFST 1740 Query: 1741 LKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV 1800 LKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV Sbjct: 1741 LKMNSDTVDYDDACLIVRYLASMRPFAQSFDIYLTQILRVLGENAIAVRTKAMKCLSEVV 1800 Query: 1801 AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDT 1860 AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDT Sbjct: 1801 AVDPSILARLDMQRGVHGRLMDNSTSVREAAVELLGRFVLCRPQLAEQYYDMLIERILDT 1860 Query: 1861 GISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPH 1920 GISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPH Sbjct: 1861 GISVRKRVIKILRDICIEQPTFPKITEMCVKMIRRVNDEEGIKKLVNETFQKLWFTPTPH 1920 Query: 1921 NDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE 1980 NDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE Sbjct: 1921 NDKEAMTRKILNITDVVAACRDTGYDWFEQLLQNLLKSEEDSSYKPVKKACTQLVDNLVE 1980 Query: 1981 HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQND 2040 HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQND Sbjct: 1981 HILKYEESLADSDNKGVNSGRLVACITTLFLFSKIRPQLMVKHAMTMQPYLTTKCSTQND 2040 Query: 2041 FMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVT 2100 FMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVT Sbjct: 2041 FMVICNVAKILELVVPLMEHPSETFLATIEEDLMKLIIKYGMTVVQHCVSCLGAVVNKVT 2100 Query: 2101 QNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED 2160 QNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED Sbjct: 2101 QNFKFVWACFNRYYGAISKLKSQHQEDPNNTSLLTNKPALLRSLFTVGALCRHFDFDLED 2160 Query: 2161 FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNIL 2220 FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNIL Sbjct: 2161 FKGNSKVNIKDKVLELLMYFTKHSDEEVQTKAIIGLGFAFIQHPSLMFEQEVKNLYNNIL 2220 Query: 2221 SDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQ 2280 SDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQ Sbjct: 2221 SDKNSSVNLKIQVLKNLQTYLQEEDTRMQQADRDWKKVAKQEDLKEMGDVSSGMSSSIMQ 2280 Query: 2281 LYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ 2340 LYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ Sbjct: 2281 LYLKQVLEAFFHTQSSVRHFALNVIALTLNQGLIHPVQCVPYLIAMGTDPEPAMRNKADQ 2340 Query: 2341 QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIR 2400 QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIR Sbjct: 2341 QLVEIDKKYAGFIHMKAVAGMKMSYQVQQAINTCLKDPVRGFRQDESSSALCSHLYSMIR 2400 Query: 2401 GNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVS 2460 GNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVS Sbjct: 2401 GNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPYQTQEEPLFIMHHIDITLSVS 2460 Query: 2461 GSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN 2520 GSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN Sbjct: 2461 GSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDIN 2520 Query: 2521 SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAI 2580 SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAI Sbjct: 2521 SVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAI 2580 Query: 2581 NRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVS 2640 NRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVS Sbjct: 2581 NRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVS 2640 Query: 2641 ASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGVRRR 2687 ASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSG RR Sbjct: 2641 ASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRR 2687 >gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] Length = 715 Score = 100 bits (248), Expect = 3e-20 Identities = 157/678 (23%), Positives = 233/678 (34%), Gaps = 104/678 (15%) Query: 588 SLKSTPENHPETPKKKS-------DPELSKSEMKQSESRLAESKPNENRLVETKSSENKL 640 S KS N P K + P SKS S R ++P+ V +K+ + Sbjct: 34 STKSATPNRSLVPTKPATSRNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKA---RT 90 Query: 641 ETKVETQTEELKQNESRTTECKQNESTIVE---PKQNENRLSDTKPNDNKQNNGRSETTK 697 ++V T T K +++ C Q T P + +R S P+ GR T Sbjct: 91 PSRVSTDTRTSKASKASDVRCHQRRGTHSRGRTPGRRGSRSSKRSPS-RASTPGRIRTHG 149 Query: 698 SRP--------ETPKQKGE-----SRPETP-KQKSDGHPETPKQKGDGRPETPKQKGESR 743 +RP T +QKG RP T +++SD P +K RP G S Sbjct: 150 ARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSY-RPPGGSGIGRSS 208 Query: 744 -----PETPK-QKNEGRPETPKHRHDNRRDSGKPSTEKK---------PEVSKHKQDTKS 788 P T K Q G P K D+ PS+ +K P K T+ Sbjct: 209 ELAVTPSTAKCQTPTGIPSKEKS------DNPSPSSSRKVKSYGQMIIPSREKSYSPTEM 262 Query: 789 DSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQK-------------SDDRGESERHRG 835 S R+KS + + RP S S S RR QK + R S +G Sbjct: 263 SS-RVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSRARSRTRKG 321 Query: 836 DQSRVRRPETLRSSSRNE---------HGIKSDSSKTDKLERKHRHESGDSRERPSSGEQ 886 S++ R RS S+ + G + S+ ER H H S+ER G Sbjct: 322 ILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSS 381 Query: 887 KSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLL 946 R +S R + G NK R ++D R+ D +++ NKA S Sbjct: 382 SPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSRSPNKARDCS--- 438 Query: 947 GGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQ 1006 RS + P RD+ + + + + +K D ++ P Sbjct: 439 --RSRS------PYKARDRSRSRSPNKARDHSRSRSPNK------ARDRSRSRSPSKERD 484 Query: 1007 KLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLC 1066 L K R +S S + + S S + +S P + +S P Sbjct: 485 HSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRS---RSPSKERQRRQSRSPNK 541 Query: 1067 ERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDR-RSS 1125 ER + R S E + S + D + R+R + EERD RS Sbjct: 542 ERDRSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSS----EERDHSRSR 597 Query: 1126 GDHRRSGHSHEGRRSSGGGRYRNRSP------SDSDMEDYSPPPSLSEVARKMKKKEKQK 1179 +++SG+S S R+R+P S S PS S V R K Sbjct: 598 SPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPT 657 Query: 1180 KRKAYEPKLTPEEMMDSS 1197 + + TP + S Sbjct: 658 RTSSLSQNRTPSKTSSHS 675 Score = 50.4 bits (119), Expect = 2e-05 Identities = 48/211 (22%), Positives = 96/211 (45%), Gaps = 14/211 (6%) Query: 599 TPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKS-SENKLETKVETQTEELKQNESR 657 +P K+ D S+S K+ + R + S E ++S S+ + + + +E +++SR Sbjct: 490 SPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSR 549 Query: 658 TTECKQNESTIVEPKQNENRL---SDTKPNDNKQNNGRSETTK-SRPETP-KQKGESRPE 712 + ++ P + +R S +K + +Q+ SE SR +P KQ G SRP Sbjct: 550 SPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPR 609 Query: 713 -TPKQKSDGHPETPKQKGDGRPE--TPKQKGESRPETPKQKNEGRPET-----PKHRHDN 764 + K+K+ TP ++G+ + K+ S+ P+ + R T ++R + Sbjct: 610 ASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPS 669 Query: 765 RRDSGKPSTEKKPEVSKHKQDTKSDSPRLKS 795 + S PST + + D+++D+ K+ Sbjct: 670 KTSSHSPSTFPSGGQTLSQDDSQADATTSKA 700 Score = 39.7 bits (91), Expect = 0.041 Identities = 27/120 (22%), Positives = 52/120 (43%), Gaps = 2/120 (1%) Query: 597 PETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNES 656 P +++ S E S SR + +R SS+ K ++ T ++E ++S Sbjct: 575 PSKERERRQSRSSSEERDHSRSRSPNKQSGYSR--PRASSKEKAHSRSRTPSKEGNHSQS 632 Query: 657 RTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQ 716 RT+ + + S P+ + + S T+ + QN S+T+ P T G++ + Q Sbjct: 633 RTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQ 692 Score = 35.8 bits (81), Expect = 0.59 Identities = 37/186 (19%), Positives = 71/186 (38%), Gaps = 29/186 (15%) Query: 590 KSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLE-TKVETQT 648 K +P K+ S+S K+ + R + S E + +++S + + ++ + + Sbjct: 493 KERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQSRSPS 552 Query: 649 EELKQNESRTTECKQNESTIVEP-KQNENRLSDTKPNDNKQNNGRS-------------- 693 EE + +SR+ +++ P K+ E R S + + + RS Sbjct: 553 EEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSRPRASS 612 Query: 694 -ETTKSRPETPKQKGE-SRPETPKQKSDGHPETPKQKGD-----------GRPETPKQKG 740 E SR TP ++G S+ T ++SD T + D + TP + Sbjct: 613 KEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLSQNRTPSKTS 672 Query: 741 ESRPET 746 P T Sbjct: 673 SHSPST 678 >gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] Length = 2752 Score = 99.0 bits (245), Expect = 6e-20 Identities = 158/736 (21%), Positives = 270/736 (36%), Gaps = 104/736 (14%) Query: 253 RLSSDDGDSSTMRNAASF-PLRSPQPVCSPAGSEGTPKGSRP-PLILQSQSLPCSSPRDV 310 RL + G S + + +SF P R + PA P+ +P L+ +S S +P+ Sbjct: 134 RLRAAFGISDSYVDGSSFDPQRRAREAKQPA-----PEPPKPYSLVRESSSSRSPTPKQK 188 Query: 311 PPDILLD--------SPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRL 362 D SP R++KK K K + E E ++ SP+ S + + Sbjct: 189 KKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESESKKRKH-----RSPTPKSKRKSKDK 243 Query: 363 SRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQ 422 R RS S P + + TS + D +R + ++ Sbjct: 244 KRKRSR-----------------STTPAPKSRRAHRSTSADSASSSDTSRS-RSRSAAAK 285 Query: 423 QEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIER 482 TA + P + A + Q+ S Sbjct: 286 THTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSP--------------------- 324 Query: 483 ESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVS 542 E+A ++ E +DKDK K + S P +TG PA + +G P + + Sbjct: 325 ETATKQPSSPYEDKDKDKKEKSATRPS-PSPERSSTGPEPPAPTPLLAERHGGSPQPLAT 383 Query: 543 IDLHQAG-RVDSQASITQDSDSIKKPEEIKQCN---DAPVSVLQEDIVGSLKSTPENHPE 598 L Q S+AS T+D K PE++ Q + +P S + S+PE+ Sbjct: 384 TPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKP 443 Query: 599 TPKKKSDPELSKSEMKQSESR------LAESKPNENRLVETKSSENKLETKVETQTEELK 652 P S E+S S ++ S + S R+ ++S + ++T + Sbjct: 444 APAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKR 503 Query: 653 -QNESRTTECKQNEST-----IVEPKQNENRLSDTKP----NDNKQNNGRSETT---KSR 699 + SR+ + +++ S P++ S +P + N Q GRS + +S Sbjct: 504 GHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSH 563 Query: 700 PETPKQKGESRPETPKQKSDGHPETPKQKGD---------GRPETPKQKGESRPETPKQK 750 +P +G SR TP ++ TP ++ R TP ++G SR TP ++ Sbjct: 564 SRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARR 623 Query: 751 NEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV 810 R +P R R + S + + ++S +P + R GRS Sbjct: 624 -RSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSR 682 Query: 811 SESLRRDHDNKQKSDDRGESERH---RGDQSRVRRPETL-RSSSRNEHGIKSDSSKTDKL 866 S + R ++ ++ RG S R +S R P+ RS S +E KS +S Sbjct: 683 SRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTS----- 737 Query: 867 ERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKS 926 +R+ R S ++ ++SR S + S S L SP K +T +S Sbjct: 738 QRRSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRS 797 Query: 927 KVDTNKAHPDNKAEFP 942 + + + P K+ P Sbjct: 798 R--SGSSQPKAKSRTP 811 Score = 85.1 bits (209), Expect = 8e-16 Identities = 121/544 (22%), Positives = 203/544 (37%), Gaps = 103/544 (18%) Query: 483 ESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVS 542 E+A ++ E +DKDK K + S P +TG PA + +G P + + Sbjct: 325 ETATKQPSSPYEDKDKDKKEKSATRPS-PSPERSSTGPEPPAPTPLLAERHGGSPQPLAT 383 Query: 543 IDLHQAG-RVDSQASITQDSDSIKKPEEIKQCNDA---PVSVLQEDIVGSLKSTPENHPE 598 L Q S+AS T+D K PE++ Q + + P S + S+PE+ Sbjct: 384 TPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKP 443 Query: 599 TPKKKSDPELSKSEMKQSESR------LAESKPNENRLVETKSSENKLETKVETQTEELK 652 P S E+S S ++ S + S R+ ++S + ++T + Sbjct: 444 APAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKR 503 Query: 653 -QNESRTTECKQNEST-----IVEPKQNENRLSDTKP----NDNKQNNGRSETTK----- 697 + SR+ + +++ S P++ S +P + N Q GRS + + Sbjct: 504 GHSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSH 563 Query: 698 ---------SRPETPKQKGESRPETPKQKSD--------------------GHPETP--- 725 SR TP ++G SR TP ++ TP Sbjct: 564 SRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARR 623 Query: 726 ------------------KQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRD 767 ++ G R TP ++G SR TP ++ R TP R Sbjct: 624 RSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARR------ 677 Query: 768 SGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRR----DHDNKQK 823 S + + ++S +PR R+ +L +R GRS S + +R +++K Sbjct: 678 ----SGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRR--GRSHSRTPQRRGRSGSSSERK 731 Query: 824 SDDRGESERHRGDQSRVRRPETLRS--SSRNEHGIKSDSSKTDKLERKHRHESGDS---R 878 + R R R + S PE +S SSR + S SK R SG S + Sbjct: 732 NKSRTSQRRSRSNSS----PEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPK 787 Query: 879 ERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNK 938 ++ + ++SR S + K R + SP K +T +S ++ HP K Sbjct: 788 QKSQTPPRRSRSGSSQPKAKSRTPPRRSR-SSSSPPPKQKSKTPSRQSH-SSSSPHPKVK 845 Query: 939 AEFP 942 + P Sbjct: 846 SGTP 849 Score = 68.9 bits (167), Expect = 6e-11 Identities = 220/1134 (19%), Positives = 374/1134 (32%), Gaps = 183/1134 (16%) Query: 124 SQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSP 183 S+ L ++ SSP QT S S P S R P+++ SP Q Sbjct: 771 SRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKS---RTPPRRSRSSSSPPPKQKS 827 Query: 184 AGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGS 243 SH SS + HP+++ + P G + + N+ S S + +P S Sbjct: 828 KTPSRQSHSSS-SPHPKVKSGT---PPRQGSITSPQANEQSVTPQRRSCFESSPDPELKS 883 Query: 244 SEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQP----VCSPAGSEGTPKGSRPPLILQS 299 H S SST + SPQP + SP + S P + S Sbjct: 884 RTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTS 943 Query: 300 QSLPCSSPRDVPPDILLDS-------------PERKQKKQKKMKLGKDEKEQSEKAAMYD 346 ++ P S R V P ++S P+ K K + + Sbjct: 944 RTTPRRS-RSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQ 1002 Query: 347 IISSPSKDSTKLTLRLSRVRSSDMDQQEDMIS---GVENSNVSENDI--PFNVQYPGQTS 401 PS +K + + S + +S GV++S ++Q GQ+ Sbjct: 1003 TPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQ 1062 Query: 402 KTPITPQDINRP---LNAAQCLSQQEQTAFLP--------------ANQVPVLQQNTSVA 444 +P D + P + ++ S Q ++ P A++ P+ Q + Sbjct: 1063 TSPDHRSDTSSPEVRQSHSESPSLQSKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFS 1122 Query: 445 AKQP-QTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIER-------ERFSKEVQ 496 A ++ + Q + Y V+ ++L R+E + E+ + + + Sbjct: 1123 ASPMLKSGMSPEQSRFQSDSSSYPTVDSNSLLGQSRLETAESKEKMALPPQEDATASPPR 1182 Query: 497 DKDK----PLKKRKQDSY---------PQEAGGATGGNRPASQETGSTGNGSRPALMVSI 543 KDK P++ R + S P+E GA Q + + LM + Sbjct: 1183 QKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAGSSPETKEQNSALPTSSQDEELMEVV 1242 Query: 544 DLHQ--AGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENH-PETP 600 + + AG++ S S S E + + P L D S S P Sbjct: 1243 EKSEEPAGQILSHLSSELKEMSTSNFESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMA 1302 Query: 601 KKKSDPELSKSEMKQSESRLAESK-------PNENRLVETKSSENKLETKVETQTEELKQ 653 P S + S S L E+ N L ++ E K + L Q Sbjct: 1303 SSWGGPHFSPEHKELSNSPLRENSFGSPLEFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQ 1362 Query: 654 NESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGR--SETTKSRPETPKQKGESRP 711 E+ + + +ST + D +N S + P TP ++ S Sbjct: 1363 LETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSA 1422 Query: 712 ETPKQKSDGHPETPKQK-----------GDGRPETPKQKGES--RPETPKQKNEGR---- 754 +P+ K DG P TP ++ G G P G S + P+ + GR Sbjct: 1423 SSPEMK-DGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECD 1481 Query: 755 --------PETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPD 806 P+TP+ R R P K + ++ S K+ L QR Sbjct: 1482 SSPEPKALPQTPRPRS---RSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSR 1538 Query: 807 GRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKL 866 S E D +R ES+ +++ R P RS S + + S S + + Sbjct: 1539 SGSSQEL---DVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPR- 1594 Query: 867 ERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKS 926 R SG SS E K +P + Q S+ S K +P + + G+ S Sbjct: 1595 ----RSRSG------SSPEVKDKPRAAPRAQSGSDSSPEPKA--PAPRALPRRSRSGSSS 1642 Query: 927 K----VDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEP 982 K + ++ E P PK + + G+ + K + + P Sbjct: 1643 KGRGPSPEGSSSTESSPEHP----------------PKSRTARRGSRSSPEPKTKSRTPP 1686 Query: 983 KDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGS 1042 + + + S + +K R +S SS +++ ++ S Sbjct: 1687 RRR-------------------SSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRS 1727 Query: 1043 IDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFES 1102 + S P E+ + ++R+RS + + K + + Sbjct: 1728 --------------PSVSSPEP-AEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQR 1772 Query: 1103 SRKRHKKDDDKAWEYEERDRRSSGDHRR----SGHSHEGRRSSGGGRYRNRSPS 1152 SR R +++ + +R S RR S RR GG Y +RSP+ Sbjct: 1773 SRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPA 1826 Score = 64.3 bits (155), Expect = 2e-09 Identities = 138/695 (19%), Positives = 249/695 (35%), Gaps = 116/695 (16%) Query: 395 QYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPA-NQVPVLQQNTSVAAKQPQTSVV 453 Q P S++P +P+ N+ L + S E + + P+ Q++ S ++++ Sbjct: 1491 QTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPS 1550 Query: 454 QNQQQISQQG-----------PIYDEVELDALAEIERIERESAIE-RERFSKEVQDKDK- 500 + Q+ S+ P+ + E++ R S R S EV+DK + Sbjct: 1551 ASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRA 1610 Query: 501 -PLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQ 559 P + DS P+ A P +GS+ G P+ +S T+ Sbjct: 1611 APRAQSGSDSSPEPKAPAPRA-LPRRSRSGSSSKGRGPS-------------PEGSSSTE 1656 Query: 560 DSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESR 619 S PE + A + TP P +S PEL++ SR Sbjct: 1657 SS-----PEHPPKSRTARRGSRSSPEPKTKSRTP---PRRRSSRSSPELTRKARLSRRSR 1708 Query: 620 LAESKPN-------ENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPK 672 A S P +R + SS E ++ + T ++ S +P+ Sbjct: 1709 SASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPR 1768 Query: 673 -----QNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG---HPET 724 ++ +R T+ + +G S++T R +Q+ SR +++ G H + Sbjct: 1769 GLQRSRSRSRREKTRTTRRRDRSGSSQSTSRR----RQRSRSRSRVTRRRRGGSGYHSRS 1824 Query: 725 PKQKGDGRPETPKQKGESR-PETPKQKNEGRPETPKHRHDNRRDSG---KPSTEKKPEVS 780 P ++ R + +++G SR P T ++++ R + R S + S + P +S Sbjct: 1825 PARQESSRTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLIS 1884 Query: 781 KHKQDTKSD--SPRLKSERAEALKQRPDGRSVSESLRRDHDN-----KQKSDDRGESERH 833 + + +++ S R R ++R R+ S RR +++S R + R Sbjct: 1885 RRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRR 1944 Query: 834 RGD---------QSRVRRPETLRSSSRNEHGI----------------KSDSSKTDKLER 868 R +SR R P R SR+ +S S + R Sbjct: 1945 RSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRR 2004 Query: 869 KHRHESGD-----SRER-PSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTE 922 + R + SR R P + ++SR +P + + S +SRS + S+ + Sbjct: 2005 RSRSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRS-RSRSPLAIRRRSRSRTPRTAR 2063 Query: 923 GNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQET--------- 973 G +S + A A G S P R+ G+ T Sbjct: 2064 GKRSLTRSPPAIRRRSAS-------GSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSC 2116 Query: 974 -KKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQK 1007 + M P D+ G++E L P+ VLQ+ Sbjct: 2117 FSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQ 2151 Score = 63.9 bits (154), Expect = 2e-09 Identities = 173/884 (19%), Positives = 313/884 (35%), Gaps = 124/884 (14%) Query: 285 EGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAM 344 E + GS P Q+ +LP SS + +++ S E Q L + KE S Sbjct: 1212 ERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEE--PAGQILSHLSSELKEMSTS--- 1266 Query: 345 YDIISSPS---KDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSEN--DIPFNVQYPGQ 399 + SSP + + LTL D Q + + VE +++ + F+ ++ + Sbjct: 1267 -NFESSPEVEERPAVSLTL--------DQSQSQASLEAVEVPSMASSWGGPHFSPEHK-E 1316 Query: 400 TSKTPITPQDINRPLNAAQC--LSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQ 457 S +P+ PL L + T F +++V + + S+ +Q Sbjct: 1317 LSNSPLRENSFGSPLEFRNSGPLGTEMNTGF--SSEVKEDLNGPFLNQLETDPSLDMKEQ 1374 Query: 458 QISQQGPIYDEVELDALAE-------------IERIERESAIERERFSKEVQDKD----K 500 G E+ DA+ + ++ + R + ER + + KD Sbjct: 1375 STRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRT 1434 Query: 501 PLKKRKQDSYPQEAGGA-------TGGNRPASQETGSTGNGSRPALMVSID---LHQAGR 550 P ++ + S P G+ G+ P ++ T + R S + L Q R Sbjct: 1435 PSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPR 1494 Query: 551 VDSQAS---------ITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPK 601 S++ +T + + Q A + Q GS + +P+ Sbjct: 1495 PRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQ 1554 Query: 602 KKSDPELSKSEMKQSESRLAE-SKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660 ++S+ + S ++ + L + S+ + V++KS + ++ + E+K Sbjct: 1555 ERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSR-SGSSPEVKDKPRAAPR 1613 Query: 661 CKQNESTIVEPKQNENRLSDTKPNDNKQNNGR------SETTKSRPETPKQ-----KGES 709 + + EPK R + + GR S +T+S PE P + +G Sbjct: 1614 AQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSR 1673 Query: 710 RPETPKQKSDGHPETPKQKGDGR--PE-TPKQKGESRPETPKQKNEGRPETPKHRHDNRR 766 PK KS TP ++ R PE T K + R + E R TP RH Sbjct: 1674 SSPEPKTKS----RTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPP-RHRRSP 1728 Query: 767 DSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDG--RSVSESLRRDHDNKQKS 824 P +K S+ ++ S + S R + +P G RS S S R ++ Sbjct: 1729 SVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRTTRRR 1788 Query: 825 DDRGESE-----RHRG-DQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSR 878 D G S+ R R +SRV R S + + +SS+T R+ G SR Sbjct: 1789 DRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRRRR-----GRSR 1843 Query: 879 ERPSSGEQKSRPDSP--------RVKQGDSNKSRS-----DKLGFKSPTSKDDKRTEGNK 925 P+S ++ SP R +SRS + +S TS +R ++ Sbjct: 1844 TPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSR 1903 Query: 926 SKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEP--- 982 + V ++ P RS P + R + + T T++ P Sbjct: 1904 TSVTRRRS---RSRASPVSRRRSRSRT------PPVTRRRSRSRTPTTRRRSRSRTPPVT 1954 Query: 983 -KDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKG 1041 + + V ++ + ++ S + + R SRS P+ + S+S Sbjct: 1955 RRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRR---SRSRTSPVTRRRSRSRTS 2011 Query: 1042 SIDQSVLK-ELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPK 1084 + + + PP + S PL R + R + + + Sbjct: 2012 PVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSR 2055 Score = 55.8 bits (133), Expect = 5e-07 Identities = 111/563 (19%), Positives = 199/563 (35%), Gaps = 107/563 (19%) Query: 437 LQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQ 496 L++ + K+P ++ ++++ VEL L E+E + E E ++ ++V Sbjct: 42 LRRLEAALVKRPNPDILDHERK--------RRVELRCL-ELEEMMEEQGYEEQQIQEKVA 92 Query: 497 DKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGS-------RPALMVSIDLHQAG 549 L ++ + +E T G RPA ET + R A +S Sbjct: 93 TFRLMLLEKDVNPGGKEE---TPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGS 149 Query: 550 RVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELS 609 D Q + +P + P S+++E S+ P +KK + Sbjct: 150 SFDPQRRAREAKQPAPEPPK-------PYSLVRE-------SSSSRSPTPKQKKKKKKKD 195 Query: 610 KSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIV 669 + +S S E K + + SE+K + K + T + K+ +S+ + K++ ST Sbjct: 196 RGRRSESSSPRRERKKSSKKKKHRSESESK-KRKHRSPTPKSKR-KSKDKKRKRSRSTTP 253 Query: 670 EPKQNENRLSDT--KPNDNKQNNGRSETTKSRPETPKQKGE----------------SRP 711 PK S + + + + RS + ++ T G S P Sbjct: 254 APKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEP 313 Query: 712 ETPKQKSDGHPET----PKQKGDGRPETPKQKGESRPETPKQKNEGRPETP------KHR 761 T + PET P + + + K+K +RP +++ PE P R Sbjct: 314 GTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAER 373 Query: 762 HDN-----------------------RRDSGKP-STEKKPEVSKHKQDTKSDSPRLKSER 797 H RD P S EK P+ S + S P S Sbjct: 374 HGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRH 433 Query: 798 AEALKQRP-------DGRSVSES-LRRDHDNKQKSDDRGESERHRGDQSRVRRPETL-RS 848 A + + P R +S S ++ + + D+ S R R P T R Sbjct: 434 ASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRG 493 Query: 849 SSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPR----------VKQG 898 SR+ K S++ + + R S R S +++ R SP+ ++G Sbjct: 494 RSRSRTPTKRGHSRS-RSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRG 552 Query: 899 DSNKSRSDKLGFKSPTSKDDKRT 921 S +R + +SP ++ R+ Sbjct: 553 RSRSARRGRSHSRSPATRGRSRS 575 Score = 54.3 bits (129), Expect = 2e-06 Identities = 97/446 (21%), Positives = 158/446 (35%), Gaps = 66/446 (14%) Query: 731 GRPETPKQKG-----ESRPETPKQKNE--------------GRPETPKHRHDNRRDSGKP 771 G+ ETP Q+ E ++KNE G P+ R R++ +P Sbjct: 107 GKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRR---AREAKQP 163 Query: 772 STEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESE 831 + E S ++ + S SP K ++ + K R RS S S RR+ K Sbjct: 164 APEPPKPYSLVRESSSSRSPTPKQKKKKKKKDR-GRRSESSSPRRERKKSSKKKKHRSES 222 Query: 832 RHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD 891 + + R P++ R S + ++ K R HR S DS SS +SR Sbjct: 223 ESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSAS--SSDTSRSRSR 280 Query: 892 SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNK--SKVDTNKAHPDNKAEFPSYLLGGR 949 S + K+ + L +SP+ +R EG+ S+ T + E Sbjct: 281 SA------AAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPE--------- 325 Query: 950 SGALKNFVIPKIKRDKD---GNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQ 1006 A K P +DKD + T+ + E + L+ + + G+ + Sbjct: 326 -TATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATT 384 Query: 1007 KLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLC 1066 LS + V + + RS K + P S+ ES+ P Sbjct: 385 PLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSS-------------------ESSPPSP 425 Query: 1067 ERVKMNKRKRST-VNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSS 1125 + K+++ S+ + KP A S E + S + S R K+D + R RS Sbjct: 426 QPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSR 485 Query: 1126 GDHRRSGHSHEGRRSSGGGRYRNRSP 1151 R + G R+RSP Sbjct: 486 SPATAKRGRSRSRTPTKRGHSRSRSP 511 Score = 45.4 bits (106), Expect = 7e-04 Identities = 46/239 (19%), Positives = 85/239 (35%), Gaps = 17/239 (7%) Query: 601 KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660 +++S S S S S + S + + + S + L + E + + E Sbjct: 2529 ERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKE 2588 Query: 661 C-KQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSD 719 ++ P + + R S + + + ++ S ++ S + S + S Sbjct: 2589 AVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2648 Query: 720 GHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEV 779 P P G PK +P ++++ + D+R S P ++P Sbjct: 2649 PSPAKP-----GPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSP 2703 Query: 780 SKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQS 838 +D +S S SER QR D RS S RR+ + + RHR +S Sbjct: 2704 QPSPRDQQSSS----SERGSRRGQRGDSRSPSHKRRRETPSPRPM-------RHRSSRS 2751 Score = 37.7 bits (86), Expect = 0.15 Identities = 54/250 (21%), Positives = 91/250 (36%), Gaps = 27/250 (10%) Query: 129 SQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMP 188 SQ+ M S A S + + +PS +PP Q SPVPS ++ QS Sbjct: 2415 SQSRMTSERAPS--PSSRMGQAPSQSLLPPAQD-------QPRSPVPSAFSDQSRCLIAQ 2465 Query: 189 YSHPSSYTTHPQMQQASVSSPIVAGGLRNI--HDNKVSGPLSGNSANHHADNPRHGSSED 246 T P S+SS VA + H+ +S P G + + P ++ Sbjct: 2466 --------TTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQ 2517 Query: 247 YLHMV--------HRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQ 298 + SS SS+ +++S S S + SEG+ +P + L+ Sbjct: 2518 PSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALK 2577 Query: 299 SQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKL 358 P +P++ + P ++K++ S ++ SS S S+ Sbjct: 2578 RVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2637 Query: 359 TLRLSRVRSS 368 + S SS Sbjct: 2638 SSSSSSSSSS 2647 Score = 34.3 bits (77), Expect = 1.7 Identities = 54/276 (19%), Positives = 103/276 (37%), Gaps = 52/276 (18%) Query: 500 KPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASI-- 557 +P K+R+ S + ++ + +S + S+G+ S DS+ S Sbjct: 2525 QPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSS---------------DSEGSSLP 2569 Query: 558 TQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSE 617 Q ++K+ + AP ++E PE P K++S S S S Sbjct: 2570 VQPEVALKR---VPSPTPAPKEAVREG------RPPEPTPAKRKRRSSSSSSSSSSSSSS 2620 Query: 618 SRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENR 677 S + S + + SS + + + + + ++ +P E R Sbjct: 2621 SSSSSSSSS------SSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERR 2674 Query: 678 -LSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPE-TPKQKSDGHPETPKQKGDGRPET 735 S KP D+ ++ ++S +P ++ P+ +P+ + E ++G Sbjct: 2675 SRSPRKPIDSLRD------SRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRRG------ 2722 Query: 736 PKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKP 771 Q+G+SR + K+ R ETP R R S P Sbjct: 2723 --QRGDSRSPSHKR----RRETPSPRPMRHRSSRSP 2752 >gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] Length = 1020 Score = 87.0 bits (214), Expect = 2e-16 Identities = 115/605 (19%), Positives = 230/605 (38%), Gaps = 82/605 (13%) Query: 477 IERIERESAI-----ERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGS- 530 +E+ E+E+ I E + ++EV ++++ K+ K++ +E GG +ET S Sbjct: 447 VEKSEKETVIVEEQTEETQVTEEVTEEEE--KEAKEEEGKEEEGGEEEEAEGGEEETKSP 504 Query: 531 -TGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQE-DIVGS 588 + P + + + ++A + + + K P E+K A +E Sbjct: 505 PAEEAASPEKEAKSPVKEEAKSPAEAK-SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPE 563 Query: 589 LKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQT 648 KS + ++P + PE +KS K+ AE+K S K ++ V+ Sbjct: 564 AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAK-----------SPEKAKSPVK--- 609 Query: 649 EELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGE 708 EE K + K+ + E K E S TK +S PE + K Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS------PEKEEAKSP 663 Query: 709 SRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDS 768 + ++P + PE K P + K + ++P ++ PE K + + ++ Sbjct: 664 EKAKSPVKAEAKSPEKAKS-----PVKAEAKSPEKAKSPVKEEAKSPE--KAKSPVKEEA 716 Query: 769 GKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRG 828 P K P + K K+ SP + ++ + P+ + + K + R Sbjct: 717 KSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARS 776 Query: 829 ESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDK-----------LERKHRHESGDS 877 +++ ++++ E ++S + + +K D+ +K ++ + + + Sbjct: 777 PADKF-PEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKV 835 Query: 878 RERPSSGEQKSRPDSPRVKQ-GDSNKSRSDKLGFKSPTSKDDKRTEGNK---SKVDTNKA 933 +E P E++ P +P+ ++ DS K + K P ++ K K SKV+ K Sbjct: 836 KEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKE 895 Query: 934 HPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVE 993 ++K + P+ +K+ E K+ +PK+K E Sbjct: 896 EAEDKKKVPT-------------------PEKEAPAKVEVKE---DAKPKEKTEVAKKEP 933 Query: 994 DLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPP 1053 D K +P +K ++ +++D K + KP K D L + P Sbjct: 934 DDAKAKEPSKPAEK------KEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPS 987 Query: 1054 ELLAE 1058 + AE Sbjct: 988 KPKAE 992 Score = 77.4 bits (189), Expect = 2e-13 Identities = 122/597 (20%), Positives = 229/597 (38%), Gaps = 68/597 (11%) Query: 591 STPENHPETP------KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKV 644 S PE P+ P K KS+ ++ E + E+ + E + E ++ E + E + E K Sbjct: 421 SLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKE 480 Query: 645 ET-------QTEELKQNESRTTECKQNESTIVEPKQN----ENRLSDTKPNDNKQNNGRS 693 E + EE + E T E+ E + E S + ++ +S Sbjct: 481 EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS 540 Query: 694 ETTKSRPETPKQKGESR---------PETPKQKSDGHPETPKQKGDGRPETPKQKGESR- 743 PE K + PE + KS ++P++ E K E++ Sbjct: 541 PAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKS 600 Query: 744 PETPKQKNEGRPETPKHRHDNRRDSGK-PSTEKKPEVSKHKQDTKSDSP-RLKSERAEAL 801 PE K + ++P ++ K P+ K PE +K ++ SP + KS E Sbjct: 601 PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA 660 Query: 802 KQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRR----PETLRSSSRNE---- 853 K +S ++ + + K KS + E++ +S V+ PE +S + E Sbjct: 661 KSPEKAKSPVKAEAKSPE-KAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP 719 Query: 854 HGIKS---DSSKTDKLERKHRHESGDSRERPSSGEQKSRPD--SPRVKQGDSNKSRSDKL 908 KS + +KT + + E S E+ S E+ D SP K ++RS Sbjct: 720 EKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPAD 779 Query: 909 GF----KSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRD 964 F KSP ++ K E KS + + P+ E P + +K+ + + ++ Sbjct: 780 KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEK--EIP------KKEEVKS-PVKEEEKP 830 Query: 965 KDGNVTQETKKMEMK---GEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDRE 1021 ++ V + KK E + PK + +K E+ K P +++ V+K + + Sbjct: 831 QEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKV 890 Query: 1022 DKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNE 1081 + + + K P+ + V ++ P+ E+ P + K + Sbjct: 891 EAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA 950 Query: 1082 KPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAW-------EYEERDRRSSGDHRRS 1131 P+ + ++ +E ++ K K+DDK + E+ ++ SS D + S Sbjct: 951 APEKKDTKEEKAKKPEEKPKTEAK--AKEDDKTLSKEPSKPKAEKAEKSSSTDQKDS 1005 Score = 68.2 bits (165), Expect = 1e-10 Identities = 129/647 (19%), Positives = 240/647 (37%), Gaps = 68/647 (10%) Query: 302 LPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLR 361 +P S P +P I S K K ++K+K+ E+SEK +I + T++T Sbjct: 418 IPFSLPEGLPK-IPSVSTHIKVKSEEKIKV----VEKSEKET---VIVEEQTEETQVTEE 469 Query: 362 LSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLS 421 ++ + ++E G E E + G +T P A+ + Sbjct: 470 VTEEEEKEAKEEE----GKEEEGGEEEEAE------GGEEETKSPP---------AEEAA 510 Query: 422 QQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIE 481 E+ A P + + + AK P+ ++ ++ + +A + E Sbjct: 511 SPEKEAKSPVKE----EAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKS 566 Query: 482 RESAIERERFSKEVQDKDKPLKKRKQDSY-PQEAGGATGGNRPASQETGSTGNGSRPALM 540 E E + EV+ +K K+++ P EA P +E S P Sbjct: 567 PEK--EEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSP--- 621 Query: 541 VSIDLHQAGRVDS-QASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPET 599 V + V S + + + + K PE+ K ++ KS + ++ Sbjct: 622 VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEK-----AKSPVKAEAKS 676 Query: 600 PKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTT 659 P+K P K+E K E + K E + E S K E K + + + E++T Sbjct: 677 PEKAKSPV--KAEAKSPEKAKSPVK-EEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP 733 Query: 660 ECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSET-TKSRPETPKQKGESRPETPKQKS 718 E K E K E S K + ++T K +P K + ++P ++ Sbjct: 734 E-KAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE 792 Query: 719 DGHPETPKQ--KGDGRP---ETPKQKGESRPETPKQK-NEGRPETPKHRHDNRRDSGKPS 772 PE K K D + E PK++ P ++K E + + P + + + P Sbjct: 793 VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPK 852 Query: 773 TEKKPEVSKHKQDTKSDSPRLK-SERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESE 831 TE+K + SK ++ K ++P+ K E+ E ++P V D K+ E+ Sbjct: 853 TEEKKD-SKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAP 911 Query: 832 RHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD 891 ++V E + + E K K K + + E+ + E+K++ Sbjct: 912 ------AKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAK-- 963 Query: 892 SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNK 938 P K K++ D SK+ + + K++ ++ D+K Sbjct: 964 KPEEKPKTEAKAKEDD----KTLSKEPSKPKAEKAEKSSSTDQKDSK 1006 Score = 66.2 bits (160), Expect = 4e-10 Identities = 97/500 (19%), Positives = 194/500 (38%), Gaps = 43/500 (8%) Query: 318 SPERKQKKQKKMKLGKDEKEQS---EKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQE 374 SPE+++ K ++ EK +S E+A SP K+ K + + +E Sbjct: 532 SPEKEEAKSPA-EVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKE 590 Query: 375 DMISGVENSNVSENDIPFNVQYPGQT-SKTPI-----TPQDINRPLNAAQCLSQQEQTAF 428 + S E + + P + +K+P+ +P ++ P A+ +++E + Sbjct: 591 EAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSP-EKAKSPTKEEAKSP 649 Query: 429 LPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIER 488 A + + AK P + ++ ++ + P+ E + A+ +E A Sbjct: 650 EKAKSPEKEEAKSPEKAKSPVKAEAKSPEKA--KSPVKAEAKSPEKAKSP--VKEEAKSP 705 Query: 489 ERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQA 548 E+ V+++ K +K K +EA P +E S P ++D+ Sbjct: 706 EKAKSPVKEEAKSPEKAKSP-VKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSP 764 Query: 549 -----GRVDSQASITQDSDSIKKP--EEIKQCNDAPVSVLQEDIVGSLKSTP-------- 593 + ++++ + + K P EE+K A S L+ED K P Sbjct: 765 EAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAK-SPLKEDAKAPEKEIPKKEEVKSP 823 Query: 594 ---ENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSEN-KLETKVETQTE 649 E P+ K K P+ ++ E + + E K ++ K + K+E K E E Sbjct: 824 VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883 Query: 650 ELKQNESRTTECKQNESTIVE--PKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKG 707 + K+++ E K+ E+ + P + + + ++ + ++E K P+ K K Sbjct: 884 KPKESK---VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE 940 Query: 708 ESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRD 767 S+P K+ + +T ++K E PK + +++ + E P PK + Sbjct: 941 PSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE--PSKPKAEKAEKSS 998 Query: 768 SGKPSTEKKPEVSKHKQDTK 787 S K PE + + K Sbjct: 999 STDQKDSKPPEKATEDKAAK 1018 Score = 52.4 bits (124), Expect = 6e-06 Identities = 83/480 (17%), Positives = 170/480 (35%), Gaps = 42/480 (8%) Query: 272 LRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKL 331 ++SP+ SPA E PP + SP +V SP +++ K + Sbjct: 544 VKSPEKAKSPAKEEA----KSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPA-EA 598 Query: 332 GKDEKEQS---EKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSEN 388 EK +S E+A SP K+ K + + +E+ S + + + Sbjct: 599 KSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658 Query: 389 DIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQP 448 + + +P+ P+ A ++ + A P + + K+ Sbjct: 659 EAKSPEKAKSPVKAEAKSPEKAKSPVKAE---AKSPEKAKSPVKEEAKSPEKAKSPVKEE 715 Query: 449 QTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERF----SKEVQDKDKPLKK 504 S + + + ++ ++ + E + E+ + E+ + S E + K + Sbjct: 716 AKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEAR 775 Query: 505 RKQDSYPQEAGGATGGNRPASQETGSTGNGSRP----ALMVSIDLHQAGRVDSQASITQD 560 D +P++A P +E S P A ++ + V S + Sbjct: 776 SPADKFPEKA------KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829 Query: 561 SDSIKKPEEIKQCND--APVSVLQEDIVGSLKS-TPENHPETPK--KKSDPELSKSEMKQ 615 +K E K+ + AP + E+ S K P+ PK +K +P + K + + Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK 889 Query: 616 SESRLAESKPNENRLVETKSSENKLETKVETQTEELKQ------------NESRTTECKQ 663 E++ E++ + K + K+E K + + +E + S+ E K+ Sbjct: 890 VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKE 949 Query: 664 NESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPE 723 + K+ + + + KP + +T P PK + + + QK PE Sbjct: 950 AAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPE 1009 Score = 50.1 bits (118), Expect = 3e-05 Identities = 87/448 (19%), Positives = 170/448 (37%), Gaps = 45/448 (10%) Query: 775 KKPEVSKHKQDTKSDSPRL--KSERAEAL-KQRPDGRSVSESLRRDHDNKQKSDDR---- 827 K P VS H + + ++ KSE+ + +++ + V+E + + + + K ++ Sbjct: 428 KIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEE 487 Query: 828 -GESERHRGDQSRVRRPETLRSSS---------RNEHGIKSDSSKTDKLERKHRHE--SG 875 GE E G + + P ++S + E +++ +K E K E S Sbjct: 488 GGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSP 547 Query: 876 DSRERPSSGEQKSRPD--SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKA 933 + + P+ E KS P+ SP ++ S KSP +K++ ++ + K+ Sbjct: 548 EKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSP-AKEEAKSPAEAKSPEKAKS 606 Query: 934 HPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVE 993 +A+ P+ K+ K +K + T+E K K + +K E + Sbjct: 607 PVKEEAKSPAEAKSPVKEEAKSPAEVK-SPEKAKSPTKEEAKSPEKAKSPEKEE----AK 661 Query: 994 DLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPP 1053 K PV K S + + +K + P+K + K + P Sbjct: 662 SPEKAKSPVKAEAK-SPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720 Query: 1054 ELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDK 1113 + + ++ E+ K ++ + EK K E + D S EA +++ + DK Sbjct: 721 KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK 780 Query: 1114 AWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPP-PSLSEVARKM 1172 + E+ + + +S + +SP D + P EV + Sbjct: 781 ---FPEKAKSPVKEEVKSPE-------------KAKSPLKEDAKAPEKEIPKKEEVKSPV 824 Query: 1173 KKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200 K++EK ++ K EP EE +T K Sbjct: 825 KEEEKPQEVKVKEPPKKAEEEKAPATPK 852 Score = 49.3 bits (116), Expect = 5e-05 Identities = 106/579 (18%), Positives = 219/579 (37%), Gaps = 97/579 (16%) Query: 109 EKSMQNRYVQSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMP 168 EK ++ + ++ K + SPA + S + PP+ S + Sbjct: 513 EKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEA 572 Query: 169 QQNSPVPSPYAPQSPAGYMPYSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLS 228 + + V SP +SPA A SP K P+ Sbjct: 573 KSPAEVKSPEKAKSPA------------KEEAKSPAEAKSP-----------EKAKSPV- 608 Query: 229 GNSANHHADNPRHGSS---EDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSE 285 A +P S E+ S + S T A +SP+ SP E Sbjct: 609 ----KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEA-----KSPEKAKSPEKEE 659 Query: 286 G-TPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLG-KDEKEQSEKAA 343 +P+ ++ P+ +++S P+ + + K +K K K+E + EKA Sbjct: 660 AKSPEKAKSPVKAEAKS----------PEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKA- 708 Query: 344 MYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKT 403 SP K+ K + + E S V+ S + +K+ Sbjct: 709 -----KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP-----------EKAKS 752 Query: 404 PITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQG 463 P + ++ + + + + ++ A PA++ P AK P V++ ++ + Sbjct: 753 PEKAKTLD--VKSPEAKTPAKEEARSPADKFP-------EKAKSPVKEEVKSPEK--AKS 801 Query: 464 PIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRP 523 P+ ++ + ++ E +S ++ E +EV+ K+ P KK +++ P A T + Sbjct: 802 PLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPP-KKAEEEKAP--ATPKTEEKKD 858 Query: 524 ASQETGSTGNGSRPAL----MVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVS 579 + +E +P + +++ + +V+++ +D + PE+ +AP Sbjct: 859 SKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEK-----EAPAK 913 Query: 580 V-LQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSEN 638 V ++ED + P+ E KK+ D +K K +E + A + + + + K E Sbjct: 914 VEVKED------AKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEE 967 Query: 639 KLETKVETQTEE--LKQNESRTTECKQNESTIVEPKQNE 675 K +T+ + + ++ L + S+ K +S+ + K ++ Sbjct: 968 KPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSK 1006 >gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens] Length = 1758 Score = 81.6 bits (200), Expect = 9e-15 Identities = 140/697 (20%), Positives = 273/697 (39%), Gaps = 105/697 (15%) Query: 582 QEDIVGSL----KSTPENHPETPKKK---SDPELSKSEMKQSESRLAESKPNENRLVETK 634 +ED VG ++ N+PE + + + +KS+ K+SE+ + K N+++ + Sbjct: 846 REDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKR 905 Query: 635 SSENKLETKVETQTEELKQNESRTTECKQN--ESTIVEPKQNENRLSDTKPNDNKQNNGR 692 + E + + E + T ++N +S V P +++ +P D + + Sbjct: 906 RKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFK 965 Query: 693 SETTKSRPET--PKQKGESRPETPKQKSDGH-----------PETPKQKGDG-RPETPKQ 738 S + K + E PK KG+ K+K+DG + P++K DG R +P+ Sbjct: 966 SVSEKDKRERDKPKAKGDK----TKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRS 1021 Query: 739 K---GESRPETPK----------QKNEGRPETPKHRHDNRRDSGKPSTEKKP-EVSKHKQ 784 + +++ ETPK QK+E TP+ H S K E KP + K K+ Sbjct: 1022 EPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSK---SAKEHQETKPVKEEKVKK 1078 Query: 785 DTKSD--SPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRR 842 D D S +L ++ +A K + + + K+K++++G + ++ + Sbjct: 1079 DYSKDVKSEKLTTKEEKAKKPNEKNKPLD---NKGEKRKRKTEEKGVDKDFESSSMKISK 1135 Query: 843 ---PETLRSSSRNEHGIKSDSSKTD-----------------KLERKHRHESGDSRERPS 882 E ++ S + + ++ D+ K D KL R+ + G + + Sbjct: 1136 LEVTEIVKPSPKRK--MEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISN 1193 Query: 883 SGE--QKSRPDSPRVKQ-----------GDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVD 929 + E +K S +VKQ + S S + + S +S ++ K D Sbjct: 1194 TKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTD 1253 Query: 930 TNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQE-----TKKMEMKGEPKD 984 T + E+ + + +P+ K DKD ++E T+ + G+P Sbjct: 1254 TKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPAS 1313 Query: 985 KVEKI-----GLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSN 1039 ++ + +V+ K ++P +QK + D ++I+ S++S K K Sbjct: 1314 VIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDR- 1372 Query: 1040 KGSIDQSVLKELPPELLAEIESTMPLCER--VKMNKRKR-STVNEKPKYAEISSDEDND- 1095 D SVL++ PE ST P E ++N++ ++++ K A S D+ Sbjct: 1373 ----DYSVLEKENPE--KRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTR 1426 Query: 1096 SDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSD 1155 + + + R KK D EY RR + R +N+ + D Sbjct: 1427 ASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERD 1486 Query: 1156 MEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEE 1192 + S + + ++ + Y+ K EE Sbjct: 1487 LPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEE 1523 Score = 75.1 bits (183), Expect = 9e-13 Identities = 163/782 (20%), Positives = 310/782 (39%), Gaps = 110/782 (14%) Query: 478 ERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRP 537 E ++ ES + K+ +++DKP K K D ++ G+ S++ P Sbjct: 955 EPMDAESITFKSVSEKDKRERDKP--KAKGDKTKRKNDGSA-----VSKKENIVKPAKGP 1007 Query: 538 ALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGS-----LKST 592 V + ++ R S+ I + + K + K + S E I G+ KS Sbjct: 1008 QEKVDGERERSPR--SEPPIKKAKEETPKTDNTKSSSS---SQKDEKITGTPRKAHSKSA 1062 Query: 593 PENHPETPKKKSDPELSKSEMKQSESRLAES----KPNE-NRLVETKSSENKLETKVETQ 647 E+ P K+ + S+ +SE + KPNE N+ ++ K + K +T+ + Sbjct: 1063 KEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGV 1122 Query: 648 TEELKQNESRTTECKQNESTIVEPKQ----NENRLSDTKPNDNKQNNGRSETTKSRPETP 703 ++ + + + ++ + E PK+ + ++ T D + ++ K ET Sbjct: 1123 DKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETG 1182 Query: 704 KQKGE----SRPETPKQKSDGHPETPKQ---KGDGRPETPKQKGESRP-----------E 745 K+ G S + P +K + KQ KG R + +G S Sbjct: 1183 KKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGG 1242 Query: 746 TPKQKNEGRPETP----KHRHDNRRDSGKPSTE-----KKPEVSKHKQDTKSDSPRLKSE 796 +P +K+E + +T K + D+ P+ + + P+ K D +S+ +KS Sbjct: 1243 SPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKST 1302 Query: 797 RAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGI 856 + + +P SV +++ N K ++ ESE ++++ S +H + Sbjct: 1303 QPISSVGKP--ASVIKNVSTKPSNIVKYPEK-ESE----PSEKIQKFTKDVSHEIIQHEV 1355 Query: 857 KS--DSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLG-FKS- 912 KS +S+ ++K + K R S +E P + ++P+ +SN R ++ G FKS Sbjct: 1356 KSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEK------ESNLDRLNEQGNFKSL 1409 Query: 913 -PTSKDDKRTEGNKS-KVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVT 970 +SK+ + ++ + S + +NK N+ + Y S + + ++ R KD Sbjct: 1410 SQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSR 1469 Query: 971 QETKKMEMKGEPKDK--VEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSL 1028 + K +P+++ + K G + + P + + E+ Sbjct: 1470 NKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDK 1529 Query: 1029 KPIKNKP-----SKSNKGSIDQSVLKEL-PPELLAEIESTMPLCERVKMNKRKRSTVNEK 1082 P K++ +++NK S +L L PPE E E ++ STV K Sbjct: 1530 NPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDK--------STVKPK 1581 Query: 1083 PKYAE---ISSDEDNDSDEA-FESSRKRHKKDDDKAWEYEERDRRSSGDHR--------- 1129 P+ + +SSD ++DEA FE + + + + EE S D + Sbjct: 1582 PQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKE 1641 Query: 1130 --------RSGHSHEGRRSSGG-GRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKK 1180 + G S SS R+ SPS S +S S +E KKK+K++K Sbjct: 1642 SLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEK 1701 Query: 1181 RK 1182 +K Sbjct: 1702 KK 1703 Score = 72.4 bits (176), Expect = 6e-12 Identities = 151/849 (17%), Positives = 314/849 (36%), Gaps = 119/849 (14%) Query: 381 ENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQN 440 E + V EN P + TP+ + ++ + +S++++ ++ Sbjct: 928 EPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDK------------RER 975 Query: 441 TSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI--ERESAIERERFSKEVQDK 498 AK +T + +S++ + + A E++ ERE + E K+ +++ Sbjct: 976 DKPKAKGDKTKRKNDGSAVSKK----ENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEE 1031 Query: 499 DKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASIT 558 K S Q+ TG R A ++ ++P + + V S+ +T Sbjct: 1032 TPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSE-KLT 1090 Query: 559 QDSDSIKKPEEI---------------------KQCNDAPVSVLQEDIVGSLKSTPEN-- 595 + KKP E K + + + + ++ +K +P+ Sbjct: 1091 TKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKM 1150 Query: 596 HPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLET--KVETQTEELKQ 653 P+T K PE K + ++ ++ ++ T++ N E K+E+ + ++KQ Sbjct: 1151 EPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQ 1210 Query: 654 NE------SRTTECKQNESTIVE----------PKQNENRLSDTK-------PNDNKQNN 690 + + T + + ST+V+ P + +DTK N N Sbjct: 1211 EKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNT 1270 Query: 691 GRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPET---- 746 +E + P+ K + + + + + T G+P + + ++P Sbjct: 1271 APAEDVIIMIQVPQSKWDK--DDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKY 1328 Query: 747 PKQKNEGRPETPKHRHDNRRDSGKPSTEK-KPEVSKHKQDTKS-DSPRLKSERAEALKQ- 803 P++++E + K D + + + K S K TK D L+ E E K Sbjct: 1329 PEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNS 1388 Query: 804 -RPDGRSVSESLRRDHDNK---QKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIK-- 857 +P+ S + L + K Q S + S++H ++ + T + ++ + Sbjct: 1389 TQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREY 1448 Query: 858 SDSSKTDKLERKHRHESGDSRERPSSGEQKSRP----DSPRVKQGDSNKSRSDKLGFKSP 913 S S + D+ R + SR + S+ QK++P D P+ GDS KS S + P Sbjct: 1449 SSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKP 1508 Query: 914 ----TSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVI--PKIKRDKDG 967 + D KR VD N K + SG +++ P+ + +K+ Sbjct: 1509 HDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKE- 1567 Query: 968 NVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSS 1027 +T + K +K +P+ L DL + + D + + +E++S + Sbjct: 1568 QITGQIDKSTVKPKPQLS-HSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGN 1626 Query: 1028 L-KPIKNKPSKSNKGSIDQSVLKEL---------PPELL---------------AEIEST 1062 + K +K+K + K S+D + + ++ P + + S+ Sbjct: 1627 ISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASS 1686 Query: 1063 MPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDR 1122 + K K+K ++K K + E +S + +HKK K + +E+++ Sbjct: 1687 AESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEK 1746 Query: 1123 RSSGDHRRS 1131 +S Sbjct: 1747 EKDDQKVKS 1755 Score = 70.9 bits (172), Expect = 2e-11 Identities = 155/797 (19%), Positives = 317/797 (39%), Gaps = 118/797 (14%) Query: 307 PRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVR 366 P P + + ER + + +K K+E +++ SS S+ K+T + Sbjct: 1003 PAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKS----SSSSQKDEKITGTPRKAH 1058 Query: 367 SSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPIT--PQDINRPLN--------- 415 S + ++ V+ V + D +V+ T+K P + N+PL+ Sbjct: 1059 SKSAKEHQET-KPVKEEKVKK-DYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRK 1116 Query: 416 -AAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDAL 474 + + + +++ + +++ V T + P+ + + +++ + P D++ L A Sbjct: 1117 TEEKGVDKDFESSSMKISKLEV----TEIVKPSPKRKMEPDTEKMDRT-PEKDKISLSAP 1171 Query: 475 AEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNG 534 A+ ++ RE+ ++ ++ + + +P +K + S + G R + TG+ G+ Sbjct: 1172 AKKIKLNRETG-KKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVR--RKVTGTEGSS 1228 Query: 535 SRPALMVSIDLHQAGRVDSQASITQDSDS-IKKPEEIKQCNDAPVSVLQEDIVGSLKSTP 593 S S V T + IK EE N AP ED++ ++ Sbjct: 1229 STLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPA----EDVIIMIQV-- 1282 Query: 594 ENHPETPKKKSDPELSKSEMKQSESRLAESKP---------NENRLVETKSSENKLETKV 644 P++ K D E + ++K ++ + KP + +V+ E++ K+ Sbjct: 1283 ---PQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKI 1339 Query: 645 ETQTE----ELKQNESRTTE---------CKQNESTIVEPKQNENRLSDTKPND------ 685 + T+ E+ Q+E ++++ K + +++E + E R + T+P Sbjct: 1340 QKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDR 1399 Query: 686 -NKQNNGRSETTKSRPETPKQKGES------RPETP----KQKSDGHPETPKQKGDGRPE 734 N+Q N +S + S+ K +S + TP K D + ++ D + E Sbjct: 1400 LNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNE 1459 Query: 735 TPKQK---GESRPETPKQKNEGRPETP---KHRHDNRRDSGKPSTEKKPEVSKHKQDTKS 788 ++K ++ QKN+ R E K D+++ + PS ++KP K DTK Sbjct: 1460 LTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKR 1519 Query: 789 DSPRLKSERAEALKQRPDGRSVSESLRRDHDNK-----QKSDDRGESERHRG--DQSRVR 841 + KS K R + + + NK + + E E+ G D+S V+ Sbjct: 1520 PNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVK 1579 Query: 842 RPETLRSSSRNEHGIKSD-SSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900 L SSR + SD + +TD+ + + DS S E++S G+ Sbjct: 1580 PKPQLSHSSR----LSSDLTRETDEAAFEPDYNESDSESNVSVKEEES--------SGNI 1627 Query: 901 NKSRSDKLGFKSPTSKDD--------KRTEGNKS-KVDTNKAHPDNKAEFPSYLLGGRSG 951 +K DK+ K+ S D R + + S V +++H + ++ S+ S Sbjct: 1628 SKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSA 1687 Query: 952 ALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLD 1011 ++ K K++K KK + + K + G +L K K +K + Sbjct: 1688 ESQDSKKKKKKKEK--------KKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN 1739 Query: 1012 DVQKLIKDREDKSRSSL 1028 ++ K+++D+ S+ Sbjct: 1740 KDKEKEKEKDDQKVKSV 1756 Score = 33.9 bits (76), Expect = 2.2 Identities = 27/105 (25%), Positives = 43/105 (40%), Gaps = 8/105 (7%) Query: 124 SQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQT--SSGNRFMPQQNSPVPSPYAPQ 181 S Y+ H S S Q ++ +P VPP +P P ++PQ Sbjct: 527 SCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQ 586 Query: 182 SPAGYMPYSHPSSYTTHPQ---MQQASVSSPIVAGGLRNIHDNKV 223 P G P P+ Y+ P A++S+P V+ G++ H N + Sbjct: 587 FPPGQPP---PAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTI 628 >gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens] Length = 1792 Score = 81.6 bits (200), Expect = 9e-15 Identities = 140/697 (20%), Positives = 273/697 (39%), Gaps = 105/697 (15%) Query: 582 QEDIVGSL----KSTPENHPETPKKK---SDPELSKSEMKQSESRLAESKPNENRLVETK 634 +ED VG ++ N+PE + + + +KS+ K+SE+ + K N+++ + Sbjct: 880 REDYVGGQSHRSRNIGSNYPEKLSARDGHNQKDNTKSKEKESENAPGDGKGNKHKKHRKR 939 Query: 635 SSENKLETKVETQTEELKQNESRTTECKQN--ESTIVEPKQNENRLSDTKPNDNKQNNGR 692 + E + + E + T ++N +S V P +++ +P D + + Sbjct: 940 RKGEESEGFLNPELLETSRKSREPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFK 999 Query: 693 SETTKSRPET--PKQKGESRPETPKQKSDGH-----------PETPKQKGDG-RPETPKQ 738 S + K + E PK KG+ K+K+DG + P++K DG R +P+ Sbjct: 1000 SVSEKDKRERDKPKAKGDK----TKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRS 1055 Query: 739 K---GESRPETPK----------QKNEGRPETPKHRHDNRRDSGKPSTEKKP-EVSKHKQ 784 + +++ ETPK QK+E TP+ H S K E KP + K K+ Sbjct: 1056 EPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSK---SAKEHQETKPVKEEKVKK 1112 Query: 785 DTKSD--SPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRR 842 D D S +L ++ +A K + + + K+K++++G + ++ + Sbjct: 1113 DYSKDVKSEKLTTKEEKAKKPNEKNKPLD---NKGEKRKRKTEEKGVDKDFESSSMKISK 1169 Query: 843 ---PETLRSSSRNEHGIKSDSSKTD-----------------KLERKHRHESGDSRERPS 882 E ++ S + + ++ D+ K D KL R+ + G + + Sbjct: 1170 LEVTEIVKPSPKRK--MEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISN 1227 Query: 883 SGE--QKSRPDSPRVKQ-----------GDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVD 929 + E +K S +VKQ + S S + + S +S ++ K D Sbjct: 1228 TKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTD 1287 Query: 930 TNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQE-----TKKMEMKGEPKD 984 T + E+ + + +P+ K DKD ++E T+ + G+P Sbjct: 1288 TKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKSTQPISSVGKPAS 1347 Query: 985 KVEKI-----GLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSN 1039 ++ + +V+ K ++P +QK + D ++I+ S++S K K Sbjct: 1348 VIKNVSTKPSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDR- 1406 Query: 1040 KGSIDQSVLKELPPELLAEIESTMPLCER--VKMNKRKR-STVNEKPKYAEISSDEDND- 1095 D SVL++ PE ST P E ++N++ ++++ K A S D+ Sbjct: 1407 ----DYSVLEKENPE--KRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTR 1460 Query: 1096 SDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSD 1155 + + + R KK D EY RR + R +N+ + D Sbjct: 1461 ASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERD 1520 Query: 1156 MEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEE 1192 + S + + ++ + Y+ K EE Sbjct: 1521 LPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEE 1557 Score = 75.1 bits (183), Expect = 9e-13 Identities = 163/782 (20%), Positives = 310/782 (39%), Gaps = 110/782 (14%) Query: 478 ERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRP 537 E ++ ES + K+ +++DKP K K D ++ G+ S++ P Sbjct: 989 EPMDAESITFKSVSEKDKRERDKP--KAKGDKTKRKNDGSA-----VSKKENIVKPAKGP 1041 Query: 538 ALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGS-----LKST 592 V + ++ R S+ I + + K + K + S E I G+ KS Sbjct: 1042 QEKVDGERERSPR--SEPPIKKAKEETPKTDNTKSSSS---SQKDEKITGTPRKAHSKSA 1096 Query: 593 PENHPETPKKKSDPELSKSEMKQSESRLAES----KPNE-NRLVETKSSENKLETKVETQ 647 E+ P K+ + S+ +SE + KPNE N+ ++ K + K +T+ + Sbjct: 1097 KEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGV 1156 Query: 648 TEELKQNESRTTECKQNESTIVEPKQ----NENRLSDTKPNDNKQNNGRSETTKSRPETP 703 ++ + + + ++ + E PK+ + ++ T D + ++ K ET Sbjct: 1157 DKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETG 1216 Query: 704 KQKGE----SRPETPKQKSDGHPETPKQ---KGDGRPETPKQKGESRP-----------E 745 K+ G S + P +K + KQ KG R + +G S Sbjct: 1217 KKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGG 1276 Query: 746 TPKQKNEGRPETP----KHRHDNRRDSGKPSTE-----KKPEVSKHKQDTKSDSPRLKSE 796 +P +K+E + +T K + D+ P+ + + P+ K D +S+ +KS Sbjct: 1277 SPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKST 1336 Query: 797 RAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGI 856 + + +P SV +++ N K ++ ESE ++++ S +H + Sbjct: 1337 QPISSVGKP--ASVIKNVSTKPSNIVKYPEK-ESE----PSEKIQKFTKDVSHEIIQHEV 1389 Query: 857 KS--DSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLG-FKS- 912 KS +S+ ++K + K R S +E P + ++P+ +SN R ++ G FKS Sbjct: 1390 KSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEK------ESNLDRLNEQGNFKSL 1443 Query: 913 -PTSKDDKRTEGNKS-KVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVT 970 +SK+ + ++ + S + +NK N+ + Y S + + ++ R KD Sbjct: 1444 SQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSR 1503 Query: 971 QETKKMEMKGEPKDK--VEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSL 1028 + K +P+++ + K G + + P + + E+ Sbjct: 1504 NKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDK 1563 Query: 1029 KPIKNKP-----SKSNKGSIDQSVLKEL-PPELLAEIESTMPLCERVKMNKRKRSTVNEK 1082 P K++ +++NK S +L L PPE E E ++ STV K Sbjct: 1564 NPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDK--------STVKPK 1615 Query: 1083 PKYAE---ISSDEDNDSDEA-FESSRKRHKKDDDKAWEYEERDRRSSGDHR--------- 1129 P+ + +SSD ++DEA FE + + + + EE S D + Sbjct: 1616 PQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKE 1675 Query: 1130 --------RSGHSHEGRRSSGG-GRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKK 1180 + G S SS R+ SPS S +S S +E KKK+K++K Sbjct: 1676 SLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEK 1735 Query: 1181 RK 1182 +K Sbjct: 1736 KK 1737 Score = 72.4 bits (176), Expect = 6e-12 Identities = 151/849 (17%), Positives = 314/849 (36%), Gaps = 119/849 (14%) Query: 381 ENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQN 440 E + V EN P + TP+ + ++ + +S++++ ++ Sbjct: 962 EPTGVEENKTDSLFVLPSRDDATPVRDEPMDAESITFKSVSEKDK------------RER 1009 Query: 441 TSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERI--ERESAIERERFSKEVQDK 498 AK +T + +S++ + + A E++ ERE + E K+ +++ Sbjct: 1010 DKPKAKGDKTKRKNDGSAVSKK----ENIVKPAKGPQEKVDGERERSPRSEPPIKKAKEE 1065 Query: 499 DKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASIT 558 K S Q+ TG R A ++ ++P + + V S+ +T Sbjct: 1066 TPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSE-KLT 1124 Query: 559 QDSDSIKKPEEI---------------------KQCNDAPVSVLQEDIVGSLKSTPEN-- 595 + KKP E K + + + + ++ +K +P+ Sbjct: 1125 TKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKM 1184 Query: 596 HPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLET--KVETQTEELKQ 653 P+T K PE K + ++ ++ ++ T++ N E K+E+ + ++KQ Sbjct: 1185 EPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENISNTKEPSEKLESTSSKVKQ 1244 Query: 654 NE------SRTTECKQNESTIVE----------PKQNENRLSDTK-------PNDNKQNN 690 + + T + + ST+V+ P + +DTK N N Sbjct: 1245 EKVKGKVRRKVTGTEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNT 1304 Query: 691 GRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPET---- 746 +E + P+ K + + + + + T G+P + + ++P Sbjct: 1305 APAEDVIIMIQVPQSKWDK--DDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKY 1362 Query: 747 PKQKNEGRPETPKHRHDNRRDSGKPSTEK-KPEVSKHKQDTKS-DSPRLKSERAEALKQ- 803 P++++E + K D + + + K S K TK D L+ E E K Sbjct: 1363 PEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNS 1422 Query: 804 -RPDGRSVSESLRRDHDNK---QKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIK-- 857 +P+ S + L + K Q S + S++H ++ + T + ++ + Sbjct: 1423 TQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREY 1482 Query: 858 SDSSKTDKLERKHRHESGDSRERPSSGEQKSRP----DSPRVKQGDSNKSRSDKLGFKSP 913 S S + D+ R + SR + S+ QK++P D P+ GDS KS S + P Sbjct: 1483 SSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKP 1542 Query: 914 ----TSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVI--PKIKRDKDG 967 + D KR VD N K + SG +++ P+ + +K+ Sbjct: 1543 HDHKATYDTKRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKE- 1601 Query: 968 NVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSS 1027 +T + K +K +P+ L DL + + D + + +E++S + Sbjct: 1602 QITGQIDKSTVKPKPQLS-HSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEESSGN 1660 Query: 1028 L-KPIKNKPSKSNKGSIDQSVLKEL---------PPELL---------------AEIEST 1062 + K +K+K + K S+D + + ++ P + + S+ Sbjct: 1661 ISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASS 1720 Query: 1063 MPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDR 1122 + K K+K ++K K + E +S + +HKK K + +E+++ Sbjct: 1721 AESQDSKKKKKKKEKKKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKNKDKEKEK 1780 Query: 1123 RSSGDHRRS 1131 +S Sbjct: 1781 EKDDQKVKS 1789 Score = 70.9 bits (172), Expect = 2e-11 Identities = 155/797 (19%), Positives = 317/797 (39%), Gaps = 118/797 (14%) Query: 307 PRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVR 366 P P + + ER + + +K K+E +++ SS S+ K+T + Sbjct: 1037 PAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKS----SSSSQKDEKITGTPRKAH 1092 Query: 367 SSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPIT--PQDINRPLN--------- 415 S + ++ V+ V + D +V+ T+K P + N+PL+ Sbjct: 1093 SKSAKEHQET-KPVKEEKVKK-DYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRK 1150 Query: 416 -AAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDAL 474 + + + +++ + +++ V T + P+ + + +++ + P D++ L A Sbjct: 1151 TEEKGVDKDFESSSMKISKLEV----TEIVKPSPKRKMEPDTEKMDRT-PEKDKISLSAP 1205 Query: 475 AEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNG 534 A+ ++ RE+ ++ ++ + + +P +K + S + G R + TG+ G+ Sbjct: 1206 AKKIKLNRETG-KKIGSTENISNTKEPSEKLESTSSKVKQEKVKGKVR--RKVTGTEGSS 1262 Query: 535 SRPALMVSIDLHQAGRVDSQASITQDSDS-IKKPEEIKQCNDAPVSVLQEDIVGSLKSTP 593 S S V T + IK EE N AP ED++ ++ Sbjct: 1263 STLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPA----EDVIIMIQV-- 1316 Query: 594 ENHPETPKKKSDPELSKSEMKQSESRLAESKP---------NENRLVETKSSENKLETKV 644 P++ K D E + ++K ++ + KP + +V+ E++ K+ Sbjct: 1317 ---PQSKWDKDDFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYPEKESEPSEKI 1373 Query: 645 ETQTE----ELKQNESRTTE---------CKQNESTIVEPKQNENRLSDTKPND------ 685 + T+ E+ Q+E ++++ K + +++E + E R + T+P Sbjct: 1374 QKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKENPEKRKNSTQPEKESNLDR 1433 Query: 686 -NKQNNGRSETTKSRPETPKQKGES------RPETP----KQKSDGHPETPKQKGDGRPE 734 N+Q N +S + S+ K +S + TP K D + ++ D + E Sbjct: 1434 LNEQGNFKSLSQSSKEARTSDKHDSTRASSNKDFTPNRDKKTDYDTREYSSSKRRDEKNE 1493 Query: 735 TPKQK---GESRPETPKQKNEGRPETP---KHRHDNRRDSGKPSTEKKPEVSKHKQDTKS 788 ++K ++ QKN+ R E K D+++ + PS ++KP K DTK Sbjct: 1494 LTRRKDSPSRNKDSASGQKNKPREERDLPKKGTGDSKKSNSSPSRDRKPHDHKATYDTKR 1553 Query: 789 DSPRLKSERAEALKQRPDGRSVSESLRRDHDNK-----QKSDDRGESERHRG--DQSRVR 841 + KS K R + + + NK + + E E+ G D+S V+ Sbjct: 1554 PNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKSTVK 1613 Query: 842 RPETLRSSSRNEHGIKSD-SSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900 L SSR + SD + +TD+ + + DS S E++S G+ Sbjct: 1614 PKPQLSHSSR----LSSDLTRETDEAAFEPDYNESDSESNVSVKEEES--------SGNI 1661 Query: 901 NKSRSDKLGFKSPTSKDD--------KRTEGNKS-KVDTNKAHPDNKAEFPSYLLGGRSG 951 +K DK+ K+ S D R + + S V +++H + ++ S+ S Sbjct: 1662 SKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSA 1721 Query: 952 ALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLD 1011 ++ K K++K KK + + K + G +L K K +K + Sbjct: 1722 ESQDSKKKKKKKEK--------KKHKKHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN 1773 Query: 1012 DVQKLIKDREDKSRSSL 1028 ++ K+++D+ S+ Sbjct: 1774 KDKEKEKEKDDQKVKSV 1790 Score = 33.9 bits (76), Expect = 2.2 Identities = 27/105 (25%), Positives = 43/105 (40%), Gaps = 8/105 (7%) Query: 124 SQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQT--SSGNRFMPQQNSPVPSPYAPQ 181 S Y+ H S S Q ++ +P VPP +P P ++PQ Sbjct: 527 SCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQ 586 Query: 182 SPAGYMPYSHPSSYTTHPQ---MQQASVSSPIVAGGLRNIHDNKV 223 P G P P+ Y+ P A++S+P V+ G++ H N + Sbjct: 587 FPPGQPP---PAGYSVPPPGFPPAPANLSTPWVSSGVQTAHSNTI 628 >gi|87299628 biorientation of chromosomes in cell division 1-like [Homo sapiens] Length = 3051 Score = 81.3 bits (199), Expect = 1e-14 Identities = 165/853 (19%), Positives = 317/853 (37%), Gaps = 134/853 (15%) Query: 437 LQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESA----------- 485 L Q S A +TS + ++ S++ P + D + ER + A Sbjct: 211 LNQEASAARASTETSNAKTSERASKKLP--SQPTTDTSTDKERTSEDMADKEKSTADSGG 268 Query: 486 --IERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSI 543 +E S+E D P+++ K +Y +E N+ QE+ N S Sbjct: 269 EGLETAPKSEEFSDLPCPVEEIK--NYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKP 326 Query: 544 DLHQAG--RVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPK 601 D ++ G + + + + D KK E+ ++ D + +E V SLK E + K Sbjct: 327 DSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQA--KEKEVESLKLPSEKNSNKAK 384 Query: 602 K----KSDPELSKSEM--------------------KQSESRLAESKPNENRLVETKSSE 637 K D L S++ + +E + S E + + E Sbjct: 385 TVEGTKEDFSLIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEE 444 Query: 638 NKLETKVETQTEELKQNESRTTEC---------------KQNESTIVEPKQN-----ENR 677 + K +TQT + + ++++ +E T+ + +Q+ E R Sbjct: 445 KNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEER 504 Query: 678 LSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPK 737 L + N K R + + + ++ K KG+ R ++S PK E K Sbjct: 505 LLRRQINREKLEEKRKQKAE-KTKSSKTKGQGRSSVDLEESSTKSLEPKAARI--KEVLK 561 Query: 738 QKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTK-SDSPRLKSE 796 ++ + K + + ++ + +++ + S+H + K S S LK Sbjct: 562 ERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKEKISSSKELKHV 621 Query: 797 RAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRG------------DQSRVRR-- 842 A++ +P R +SESL +NK +S E +R D V+R Sbjct: 622 HAKSEPSKP-ARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQV 680 Query: 843 ---------PETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSP 893 P+ +S+ +NE +K D S+T L+ + E S+E+P E++ P Sbjct: 681 ERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLLKKEVKSSKEKP---EREKTPSED 737 Query: 894 RV------------KQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEF 941 ++ K GD + S + G K + + + S D + ++ E Sbjct: 738 KLSVKHKYKGDCMHKTGDETELHSSEKGLKVEENIQKQSQQTKLSSDDKTERKSKHRNER 797 Query: 942 PSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKME-------MKGEPKDKVEKIGLVED 994 +LG + ++I D NV +E K E K E K + ++ Sbjct: 798 KLSVLGKDGKPVSEYII-----KTDENVRKENNKKERRLSAEKTKAEHKSRRSSDSKIQK 852 Query: 995 LNKGAKP-VVVLQKLSLDDVQKLIKDREDKSRSSLKP--IKNKPSKSNKGSIDQSVLKEL 1051 + G+K + LQ+ S + S+LKP + +K + K +++ ++ L Sbjct: 853 DSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEVVHKEKRRTKSLLEEKLV--L 910 Query: 1052 PPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDD 1111 + + + + ++ K++T PK + + E+NDS++ S+ K + Sbjct: 911 KSKSKTQGKQVKVVETELQEGATKQATT---PKPDKEKNTEENDSEKQ-RKSKVEDKPFE 966 Query: 1112 DKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDS-----DMEDYSPPPSLS 1166 + E SS + SH + +Y++ S S + D SL Sbjct: 967 ETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLK 1026 Query: 1167 EVARKMKKKEKQK 1179 ++ +KKK++ K Sbjct: 1027 HSSKDIKKKDENK 1039 Score = 78.6 bits (192), Expect = 8e-14 Identities = 198/989 (20%), Positives = 366/989 (37%), Gaps = 166/989 (16%) Query: 320 ERKQKKQKKMKLGK---------DEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDM 370 E+K+K +KK K DEK+ EK + S + T+ ++ S + Sbjct: 337 EKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLI 396 Query: 371 DQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLP 430 D D ++ + S+V +D+ + T + +T + + S E+ Sbjct: 397 DSDVDGLTDITVSSVHTSDLS---SFEEDTEEEVVTSDSMEE----GEITSDDEEK---- 445 Query: 431 ANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERER 490 N+ + TS +++ SV + + +Y + D+ E+ +R +I +E+ Sbjct: 446 -NKQNKTKTQTSDSSEGKTKSV---RHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEK 501 Query: 491 FSKEVQ---DKDKPLKKRKQDSYPQEAGGATG-GNRPASQETGSTGNGSRPALMVSIDLH 546 + ++ +++K +KRKQ + ++ G G E ST + A + L Sbjct: 502 EERLLRRQINREKLEEKRKQKAEKTKSSKTKGQGRSSVDLEESSTKSLEPKAARIKEVLK 561 Query: 547 QAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDP 606 + ++ + ++++ KK + N +ED +LK++ H E K S Sbjct: 562 ERKVLEKKVALSKKR---KKDSRNVEENSKKKQQYEEDSKETLKTS--EHCEKEKISSSK 616 Query: 607 ELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNES 666 EL K S+ A +V+ +E+KLE ++++ RT+ Sbjct: 617 ELKHVHAKSEPSKPARRLSESLHVVDENKNESKLE----------REHKRRTST-----P 661 Query: 667 TIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPK 726 I+E Q E T D K+ RSE P+ KQK + E +K D ETP Sbjct: 662 VIMEGVQEE-----TDTRDVKRQVERSEICTEEPQ--KQKSTLKNEKHLKKDDS--ETPH 712 Query: 727 QKGDGRPETPKQKGESRPETPKQKNEGRPETPKHR------HDNRRDSGKPSTEK----K 776 K + E K +PE K +E + KH+ H ++ S+EK + Sbjct: 713 LKSLLKKEVKSSK--EKPEREKTPSEDKLSV-KHKYKGDCMHKTGDETELHSSEKGLKVE 769 Query: 777 PEVSKHKQDTKSDSPRLKSERAEALKQRP------DGRSVSESLRRDHDNKQKSDDR--- 827 + K Q TK S +++ +R DG+ VSE + + +N +K +++ Sbjct: 770 ENIQKQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKENNKKER 829 Query: 828 --------GESERHRGDQSRVRRPE--------TL--RSSSRNEHGIKSDSS------KT 863 E + R S++++ TL RS S +E DS+ K Sbjct: 830 RLSAEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKP 889 Query: 864 DKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEG 923 +++ K + + E + KS+ +VK ++ +P +K TE Sbjct: 890 EEVVHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEE 949 Query: 924 NKSKVDTNKAHPDNKAE----------FPSYLLGGRSGALKNFVIP----KIKRDKDGNV 969 N S+ D E S + + +P K K DKD Sbjct: 950 NDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKDSSHRAKLPLAKEKYKSDKDSTS 1009 Query: 970 TQETKKME-------MKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDRED 1022 T+ +K+ +K KD +K D NK S D K + + Sbjct: 1010 TRLERKLSDGHKSRSLKHSSKDIKKK-----DENK-----------SDDKDGKEVDSSHE 1053 Query: 1023 KSRSSLKPIKNKPSK----SNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRST 1078 K+R + ++ K S+ + +GS+ Q + K E LA + P ++ K+ Sbjct: 1054 KARGNSSLMEKKLSRRLCENRRGSLSQEMAKG--EEKLAANTLSTPSGSSLQRPKKSGDM 1111 Query: 1079 ----------VNEKP---KYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSS 1125 ++ +P E+S +DN ++ + + + K A ++ R + Sbjct: 1112 TLIPEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTSATVQKDELRTCT 1171 Query: 1126 GDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYE 1185 D + + +++ R G G N + + KM EK+ + Sbjct: 1172 ADSKATAPAYKPGR--GTGVNSNSEKHADHRSTLTKKMHIQSAVSKMNPGEKEPIHRG-- 1227 Query: 1186 PKLTPEEMMDSSTFKRFTASIENILDNLE 1214 T E +DS T R S + D ++ Sbjct: 1228 ---TTEVNIDSETVHRMLLSAPSENDRVQ 1253 Score = 58.2 bits (139), Expect = 1e-07 Identities = 94/508 (18%), Positives = 197/508 (38%), Gaps = 81/508 (15%) Query: 734 ETPKQKGESRPETPKQKNEGRP-ETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPR 792 E +K S+P T ++ R E + + DSG E P K + SD P Sbjct: 231 ERASKKLPSQPTTDTSTDKERTSEDMADKEKSTADSGGEGLETAP-----KSEEFSDLPC 285 Query: 793 LKSERAEALKQRPDGRSVSESLRRDH-DNKQKSDDRGESERHRGDQSRVRRPETLRSSSR 851 E K+ + +++ ++++ + K KS D+GE + ++ ++ + ++ + Sbjct: 286 PVEEIKNYTKEHNNLILLNKDVQQESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKK 345 Query: 852 NEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQG------------- 898 +H KS+ ++ K E++ + + +S + PS K+ Sbjct: 346 FDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDGLTD 405 Query: 899 --DSNKSRSDKLGFKSPTSKD----DKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGA 952 S+ SD F+ T ++ D EG + D K + S G++ + Sbjct: 406 ITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKS 465 Query: 953 L------KNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQ 1006 + K ++ K D D +T E ++ + E +++ ++ + Sbjct: 466 VRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEER-----------------LLRR 508 Query: 1007 KLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLC 1066 +++ + +++ K + +K++SS K K + +++S K L P+ Sbjct: 509 QINREKLEEKRKQKAEKTKSS----KTKGQGRSSVDLEESSTKSLEPK-----------A 553 Query: 1067 ERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDD-----KAWEYEERD 1121 R+K ++R + +K +S DS E+S+K+ + ++D K E+ E++ Sbjct: 554 ARIKEVLKERKVLEKK---VALSKKRKKDSRNVEENSKKKQQYEEDSKETLKTSEHCEKE 610 Query: 1122 RRSSGD-----HRRSGHSHEGRRSSGG----GRYRNRSPSDSDMEDYSPPPSLSEVARKM 1172 + SS H +S S RR S +N S + + + + P + E ++ Sbjct: 611 KISSSKELKHVHAKSEPSKPARRLSESLHVVDENKNESKLEREHKRRTSTPVIMEGVQEE 670 Query: 1173 KKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200 K++ T E ST K Sbjct: 671 TDTRDVKRQVERSEICTEEPQKQKSTLK 698 Score = 57.0 bits (136), Expect = 2e-07 Identities = 71/285 (24%), Positives = 118/285 (41%), Gaps = 45/285 (15%) Query: 644 VETQTEELKQNESRTTECKQNE---STIVEPKQNENRLS-----------DTKPNDNKQN 689 VE +E+++ E + K+ + S+ EP N + L +T+P+D K+ Sbjct: 2754 VEADPKEVEEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEE 2813 Query: 690 NGRS-----ETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRP 744 N R +T+ T + E + E ++ G E P+Q D +T K + E +P Sbjct: 2814 NSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTG--EKPEQNDD---DTIKSQEEDQP 2868 Query: 745 ETPKQKNEGRPE------TPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERA 798 K+K GRP T K + D++ D+G + E+ P SK K +S + + Sbjct: 2869 IIIKRK-RGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQ 2927 Query: 799 EALKQRPDG--RSVSESLRRDHDNKQK---SDDRGESERHRGDQSRVRRPETLRSSSRNE 853 E DG + V+ RR K+ SDD SE R Q V P E Sbjct: 2928 ERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPV--------E 2979 Query: 854 HGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD-SPRVKQ 897 + +S + ++ E + +R S Q+S+ SP +K+ Sbjct: 2980 DKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKR 3024 Score = 48.5 bits (114), Expect = 9e-05 Identities = 85/407 (20%), Positives = 159/407 (39%), Gaps = 41/407 (10%) Query: 548 AGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPE 607 +G+ QAS + D + + D V+V E+ V + + E+P Sbjct: 2610 SGKWTDQASAEKTGDDNSTRKSFPEEGDIMVTVSSEENVCDI-----GNEESPLNVLGGL 2664 Query: 608 LSKSEMKQSESRLAESKPNENRLVETKS-SENKLETKVETQTEELKQNESRTTECK--QN 664 K+ +K +E + N L +S K E Q E L NES E + Sbjct: 2665 KLKANLKMEAYVPSEEEKNGEILAPPESLCGGKPSGIAELQREPLLVNESLNVENSGFRT 2724 Query: 665 ESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPET 724 I N+ +S +++N + + S PK+ E PK+K H + Sbjct: 2725 NEEIHSESYNKGEISS-----GRKDNAEAISGHSVEADPKEVEEEERHMPKRKRKQHYLS 2779 Query: 725 PKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQ 784 + + D P+ +SR ET +++ PET H D+ + ++ E+ K Sbjct: 2780 SEDEPDDNPDVL----DSRIETAQRQ---CPETEPH------DTKEENSRDLEELPKTSS 2826 Query: 785 DTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGES---ERHRGDQSRVR 841 +T S + R+ E+ E G E ++ D+ KS + + +R RG + Sbjct: 2827 ETNSTTSRVMEEKDEYSSSETTG----EKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYP 2882 Query: 842 RPETL--RSSSRNEHGI----KSDSSKTDKLER--KHRHESGDSRERPSSGEQKSRPDSP 893 TL + S+ + GI +S SS K+ + + E+ + +ER S + Sbjct: 2883 VETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVT 2942 Query: 894 RVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAE 940 V++ RS + + +S+ +++ + + S +K ++ E Sbjct: 2943 SVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEE 2989 Score = 45.8 bits (107), Expect = 6e-04 Identities = 168/792 (21%), Positives = 272/792 (34%), Gaps = 133/792 (16%) Query: 317 DSPERKQKKQKKMKL---GKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRV-------- 365 D ERK K + + KL GKD K SE D + K++ K RLS Sbjct: 785 DKTERKSKHRNERKLSVLGKDGKPVSEYIIKTD--ENVRKENNKKERRLSAEKTKAEHKS 842 Query: 366 -RSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQE 424 RSSD Q+D + ++ + + Y T D N L + + +++ Sbjct: 843 RRSSDSKIQKDSLGSKQHGITLQRR---SESYSEDKCDMDSTNMDSN--LKPEEVVHKEK 897 Query: 425 QTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERES 484 + + VL+ + KQ + + Q+ ++Q + E+ E+ Sbjct: 898 RRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATT-------PKPDKEKNTEEN 950 Query: 485 AIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSID 544 E++R SK V+DK P E G AS ST S Sbjct: 951 DSEKQRKSK-VEDK------------PFEETGVEPVLETASSSAHSTQKDSS-------- 989 Query: 545 LHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKS 604 H+A ++ D DS E ++ +D S SLK + ++ + + KS Sbjct: 990 -HRAKLPLAKEKYKSDKDSTSTRLE-RKLSDGHKS-------RSLKHSSKDIKKKDENKS 1040 Query: 605 DPELSKS-----EMKQSESRLAESKPN----ENRLVETKSSENKLETKVETQTEELKQNE 655 D + K E + S L E K + ENR K E K+ T Sbjct: 1041 DDKDGKEVDSSHEKARGNSSLMEKKLSRRLCENRRGSLSQEMAKGEEKLAANTLSTPSGS 1100 Query: 656 SRTTECKQNESTIVEPKQN----------ENRLSDTKPNDNKQNNGR----SETTKSRPE 701 S K + T++ P+Q EN +K DN+ NN + SE K + Sbjct: 1101 SLQRPKKSGDMTLI-PEQEPMEIDSEPGVENVFEVSKTQDNRNNNSQQDIDSENMKQKTS 1159 Query: 702 TPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHR 761 QK E R T K+ P +G ++ + R K Sbjct: 1160 ATVQKDELRTCTADSKATA------------PAYKPGRGTGVNSNSEKHADHRSTLTKKM 1207 Query: 762 HDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNK 821 H S EK+P + + + DS + + S ++D Sbjct: 1208 HIQSAVSKMNPGEKEP-IHRGTTEVNIDSETV--------------HRMLLSAPSENDRV 1252 Query: 822 QKSDDRGESERH--RGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRE 879 QK+ +E H +GD TL S+ + S L + + + Sbjct: 1253 QKNLKNTAAEEHVAQGD-------ATLEHSTNLDSSPSLSSVTVVPLRESYDPDVIPLFD 1305 Query: 880 RPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDT-NKAHPDNK 938 + + E + SP N+S + + TS D + G VDT KA +K Sbjct: 1306 KRTVLEGSTASTSPADHSALPNQSLTVRESEVLKTS--DSKEGGEGFTVDTPAKASITSK 1363 Query: 939 AEFP----SYLLGGRSG--------ALKNFVIPKIKRDKDGNVTQETKK-MEMKGEPKDK 985 P + LL G+ G L ++ K+G + KK ++ EP K Sbjct: 1364 RHIPEAHQATLLDGKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLK 1423 Query: 986 VEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGS-ID 1044 VE+ K V + L+ + + +K + +S +K I + N+ S +D Sbjct: 1424 QTIKATVENGKKDGIAVDHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRNENSEVD 1483 Query: 1045 QSVLKELPPELL 1056 S P +L Sbjct: 1484 TSAGSGSAPSVL 1495 Score = 43.9 bits (102), Expect = 0.002 Identities = 51/241 (21%), Positives = 88/241 (36%), Gaps = 25/241 (10%) Query: 527 ETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIV 586 +T S N + +M D + + + D D+IK EE D P+ I+ Sbjct: 2823 KTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEE-----DQPI------II 2871 Query: 587 GSLKSTPENHP-ETPKK-----KSDPELSKSEMKQSESRLA-----ESKPNENRLVETKS 635 + P +P ET K K+D + E S S+L ES L E Sbjct: 2872 KRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSI 2931 Query: 636 SENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNG--RS 693 S + E K+ T + R+ + + ++ + +SD + +Q + Sbjct: 2932 SNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEE 2991 Query: 694 ETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEG 753 E + P + +R E + K+ P K+K + P + +G+ R E K Sbjct: 2992 EEEEDEPSGATTRSTTRSEAQRSKTQLSPSI-KRKREVSPPGARTRGQQRVEEAPVKKAK 3050 Query: 754 R 754 R Sbjct: 3051 R 3051 Score = 37.7 bits (86), Expect = 0.15 Identities = 64/378 (16%), Positives = 142/378 (37%), Gaps = 42/378 (11%) Query: 810 VSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERK 869 V+ESL ++ + +++ ++G+ S R+ S H +++D + +E + Sbjct: 2711 VNESLNVENSGFRTNEEIHSESYNKGEISSGRKDNAEAISG---HSVEADPKE---VEEE 2764 Query: 870 HRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVD 929 RH R++ + D+P V SR + + P ++ E N ++ Sbjct: 2765 ERHMPKRKRKQHYLSSEDEPDDNPDVLD-----SRIETAQRQCPETEPHDTKEENSRDLE 2819 Query: 930 TNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKI 989 E P ++ + N ++ +KD + ET + + D ++ Sbjct: 2820 ----------ELP------KTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKS- 2862 Query: 990 GLVEDLNKGAKPVVVLQKLSLD---DVQKLIKDRED-KSRSSLKPIKNKPSKSNKGSIDQ 1045 + +P+++ +K V+ +K ++D K+ + + ++ PS S + Sbjct: 2863 ------QEEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQT 2916 Query: 1046 SVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYA-EISSDEDNDSDEAFESSR 1104 + L S E++ + R+R KPK + +S D ++ E Sbjct: 2917 DESNKETANLQERSISNDDGEEKIVTSVRRRG---RKPKRSLTVSDDAESSEPERKRQKS 2973 Query: 1105 KRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPS 1164 +D K E +E + D + RS SPS + SPP + Sbjct: 2974 VSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVSPPGA 3033 Query: 1165 LSEVARKMKKKEKQKKRK 1182 + +++++ +K ++ Sbjct: 3034 RTRGQQRVEEAPVKKAKR 3051 Score = 32.3 bits (72), Expect = 6.5 Identities = 46/214 (21%), Positives = 83/214 (38%), Gaps = 27/214 (12%) Query: 2439 PYQTQEEPLFIMHHIDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSD----SE 2494 P+ T+EE + + T S + S + +E KD+ +++ K ++ D S+ Sbjct: 2807 PHDTKEENSRDLEELPKTSSETNSTTSRVMEE---KDEYSSSETTGEKPEQNDDDTIKSQ 2863 Query: 2495 EE-----VSRPRKSRKRVDSDSDSDSEDDINSVMKCLPENSAPLIEFANVSQGILLLLML 2549 EE + R R ++ ++ +DD + + +P S L ++ Sbjct: 2864 EEDQPIIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSP-------SSSKLKVMQT 2916 Query: 2550 KQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEE 2609 + K + I E + RK PK++L SD A S E Sbjct: 2917 DESNKETANLQERSISNDDGEEKIVTSVRRRGRK------PKRSLTV--SDDAESSEPER 2968 Query: 2610 VKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSAST 2643 ++ V ++ K E + +EEEEE E S +T Sbjct: 2969 KRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGAT 3002 >gi|42560244 peptidylprolyl isomerase G [Homo sapiens] Length = 754 Score = 81.3 bits (199), Expect = 1e-14 Identities = 121/583 (20%), Positives = 212/583 (36%), Gaps = 61/583 (10%) Query: 553 SQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSE 612 S +S + DSDS + +D+ + ++ K + +KK + KS Sbjct: 196 SSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSA 255 Query: 613 MKQSESRLAESKPN------------ENRLVETKSSENKLETKVETQTEELKQNESRTTE 660 +SE+ E++P ENR + KS + E + R E Sbjct: 256 SSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPK------ADEKERKNRERERERE 309 Query: 661 CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG 720 C S +P + RL T+ + G R TP + SR + ++ Sbjct: 310 CNPPNS---QPASYQRRLLVTRSGRKIKGRG-----PRRYRTP-SRSRSRDRFRRSETPP 360 Query: 721 HPETPKQKGDGRPETPKQ---KGESRPETPKQKNEGRPETPKHR----HDNRRDSGKPST 773 H Q+ + + KG+ ++N+ P K R H N +S Sbjct: 361 HWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKN 420 Query: 774 EKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERH 833 EK+ +V HK ++K R SE+ + K + R+ S+S R K KS +R +S+ + Sbjct: 421 EKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKS-RSKSKEKSKSKER-DSKHN 478 Query: 834 RGDQSRVRRPETLRSSSRNEHGIK----------SDSSKTDKLERKHRHESGDSRERPSS 883 R ++ R+R RS R+ +K D ++ E+ + ES + S Sbjct: 479 RNEEKRMRS----RSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSK 534 Query: 884 GEQKSRPDSPRVKQGDSNK---SRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAE 940 ++K R R ++ D K S + + +S + +R D +++ ++ Sbjct: 535 SKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYR 594 Query: 941 FPSYLLGGRSGALKNFVIPKIKRDKD----GNVTQETKKMEMKGEPKDKVEKIGLVEDLN 996 Y GRS + + P R KD ++ +++ E + KDK Sbjct: 595 EQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHR 654 Query: 997 KGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELL 1056 K D RE K+ P S + S+LK E Sbjct: 655 KENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDE-- 712 Query: 1057 AEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEA 1099 +I S++ E K ++ V+EK K + S D D++ Sbjct: 713 -KIRSSVEK-ENQKSKGQENDHVHEKNKKFDHESSPGTDEDKS 753 Score = 66.6 bits (161), Expect = 3e-10 Identities = 113/547 (20%), Positives = 199/547 (36%), Gaps = 49/547 (8%) Query: 740 GESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAE 799 GE P++ +K E K RH + S S++ SDS E+++ Sbjct: 175 GELIPKSKVKKEE------KKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSK 228 Query: 800 ALKQ--RPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIK 857 K+ R + R + ++ +K+ + E+E RPE + N ++ Sbjct: 229 KRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMR 288 Query: 858 SDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRV-KQGDSNKSRSDKLGFKSPTSK 916 K D+ ERK+R + P + + S V + G K R + +++P S+ Sbjct: 289 KSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPR-RYRTP-SR 346 Query: 917 DDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKM 976 R +S+ + +A+ G R + +IK ++ V + +K+ Sbjct: 347 SRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKI 406 Query: 977 ----EMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIK 1032 + P K EK V+D +K + + DD K + KS+S K + Sbjct: 407 TDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKE 466 Query: 1033 NKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRK---RSTVNEKPKYAEIS 1089 SK +++ K + + E+ +K K RS EK K E Sbjct: 467 KSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESK 526 Query: 1090 SDEDNDSDEAFESSRKRHKKDDD-------KAWEYEERDRRSSGDH----RRSGHSHEGR 1138 S+E +D ++ E R+ + + ++ R+R S D R H + Sbjct: 527 SNE-HDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRS 585 Query: 1139 RSSGGGRYRN---RSPSDSDMEDYSPPPSLSEV---------ARKMKKKEKQKKRK---- 1182 RS RYR R S + PP S +R +++E Q + K Sbjct: 586 RSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYR 645 Query: 1183 AYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQELLLGKHQLNELG 1242 E K + + S + ++ S ++ N + D D+ P + Q NEL Sbjct: 646 NQESKSSHRKENSESEKRMYSKSRDH---NSSNNSREKKADRDQSPFSKIKQSSQDNELK 702 Query: 1243 SESAKIK 1249 S K K Sbjct: 703 SSMLKNK 709 Score = 64.3 bits (155), Expect = 2e-09 Identities = 94/538 (17%), Positives = 195/538 (36%), Gaps = 32/538 (5%) Query: 472 DALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGST 531 D+ + + + ESA E + ++ + + K +K+ +++ + A Sbjct: 209 DSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQP 268 Query: 532 GNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCN---DAPVSVLQEDIVGS 588 + RP + I ++ S + ++ E ++CN P S + +V Sbjct: 269 QSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLV-- 326 Query: 589 LKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETK-----SSENKLETK 643 +S + P++ P S+S + R +E+ P+ + ++ SS + Sbjct: 327 TRSGRKIKGRGPRRYRTPSRSRS---RDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKG 383 Query: 644 VETQTEELKQNESRTTECKQNESTI---VEPKQNENRLSDTKPNDNKQNNGRSETTKSRP 700 +++ E+K+N+ K+ + T V N + K D+K N+ + ++ Sbjct: 384 DKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSE 443 Query: 701 ETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKH 760 + K K + + + E K K ++ R + + +E E K Sbjct: 444 KDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQ 503 Query: 761 RHDNRRDSGKP-STEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPD---GRSVSESLRR 816 +D + S EK ++ + + K RA++ + D G+ S R Sbjct: 504 SDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTR 563 Query: 817 DHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGI------KSDSSKTDKLERKH 870 + + R S H D+SR + R G ++ ++ +R+ Sbjct: 564 ERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRR 623 Query: 871 RHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDT 930 R S ER S Q D R ++ S+ + + K SK N S+ Sbjct: 624 RRRDSRSSEREES--QSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSR--- 678 Query: 931 NKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEK 988 K +++ F + LK+ ++ K K D+ + E + + KG+ D V + Sbjct: 679 EKKADRDQSPFSKIKQSSQDNELKSSML-KNKEDEKIRSSVEKENQKSKGQENDHVHE 735 Score = 62.4 bits (150), Expect = 6e-09 Identities = 120/614 (19%), Positives = 222/614 (36%), Gaps = 97/614 (15%) Query: 639 KLETKVETQTEELKQNESRTTECKQN-ESTIVEPKQNENRLSDTKPNDNKQNNGRSETTK 697 +L K + + EE K+++S ++ + +S Q+ + SD++ +++ R + + Sbjct: 176 ELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHR 235 Query: 698 SRPETPKQKGESRPETPKQ---KSDGHPETPKQKGDGRPE----TPKQKGESRPETPK-- 748 K++ + R ++ K +S+ + + RPE P+ + R PK Sbjct: 236 KNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKAD 295 Query: 749 QKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGR 808 +K E + R N +S S +++ V++ + K PR R Sbjct: 296 EKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRY-------------R 342 Query: 809 SVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLER 868 + S S RD + ++ E R + RV S E IK D S+ ++++ Sbjct: 343 TPSRSRSRDRFRRSETPPHWRQEMQRAQRMRV---------SSGERWIKGDKSELNEIKE 393 Query: 869 KHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKV 928 R P +++ D V + + K+ +K ++ ++ N K Sbjct: 394 NQR--------SPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKD 445 Query: 929 DTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETK-KMEMKGEPKDKVE 987 D K +A+ S K +RD N +E + + KG + V+ Sbjct: 446 DKYKNKVKKRAKSKSRSKSKEKSKSK-------ERDSKHNRNEEKRMRSRSKGRDHENVK 498 Query: 988 KIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSV 1047 + D +KG KD+E +SRS K K SKSN+ +S Sbjct: 499 EKEKQSD-SKG-------------------KDQE-RSRSKEKS-KQLESKSNEHDHSKSK 536 Query: 1048 LKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRH 1107 K+ R + R+ K Y + + D + + H Sbjct: 537 EKD----------------RRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTH 580 Query: 1108 KKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSE 1167 +D ++ EY R ++RR G S R + GR R++ + S S+ Sbjct: 581 DRDRSRSKEYH---RYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQ 637 Query: 1168 VARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAF------ 1221 K K + ++ K + E+ M S + R S N + D D + F Sbjct: 638 SRNKDKYRNQESKSSHRKENSESEKRMYSKS--RDHNSSNNSREKKADRDQSPFSKIKQS 695 Query: 1222 GDDDEIPQELLLGK 1235 D+E+ +L K Sbjct: 696 SQDNELKSSMLKNK 709 Score = 32.7 bits (73), Expect = 5.0 Identities = 40/175 (22%), Positives = 63/175 (36%), Gaps = 54/175 (30%) Query: 2381 GFRQDESSSALCSHLYSMIRGNRQHRRAFLISLLNLFDDTAKTDVTMLLYIADNLACFPY 2440 GF +DES + +H + FL+S+ N DT N + F Sbjct: 93 GFFEDESFAV-------------KHNKEFLLSMANRGKDT-------------NGSQFFI 126 Query: 2441 QTQEEPLFIMHHIDITLSVSGSNLLQSF-------------------------KESMVKD 2475 T+ P HH+ +SG +++ K + K+ Sbjct: 127 TTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKE 186 Query: 2476 KRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPENS 2530 ++K KSS S + SSDS+ S SDS+S +E+ K +NS Sbjct: 187 EKKRHKSSSSSSSSSSDSDSSSDSQSSSDS---SDSESATEEKSKKRKKKHRKNS 238 >gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] Length = 1007 Score = 80.5 bits (197), Expect = 2e-14 Identities = 129/596 (21%), Positives = 234/596 (39%), Gaps = 66/596 (11%) Query: 470 ELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETG 529 +LD LA +E +E++ A+ + E+ ++ + Q G G+ + Sbjct: 99 KLDDLALLEDLEKQRALIKAELDNEL------MEGKVQSGMGLILQGYESGSEEEGEIHE 152 Query: 530 STGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSL 589 NG+R + S + VD++ + + S S K E + +D S +IV Sbjct: 153 KARNGNRSSTRSSSTKGKLELVDNKITTKKRSKSRSK-ERTRHRSDKKKSKGGIEIVKE- 210 Query: 590 KSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTE 649 K+T E K KS + SKS Q ++R ++S R S+ K+ K + T+ Sbjct: 211 KTTRSKSKERKKSKSPSKRSKS---QDQARKSKSPTLRRR------SQEKIG-KARSPTD 260 Query: 650 ELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGES 709 + + E ++ + +S I+ ++ +R K G+S+ +SR + K K Sbjct: 261 DKVKIEDKSKSKDRKKSPIINESRSRDR--GKKSRSPVDLRGKSKDRRSRSKERKSK--- 315 Query: 710 RPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSG 769 R ET K+K K + + ++ S P + + R +PK R +RR Sbjct: 316 RSETDKEKKP-------IKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRS 368 Query: 770 KPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDN----KQKSD 825 +++ + SK T S R KS E ++ P+ R +S R D+ +++S Sbjct: 369 PLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSK 428 Query: 826 DRGESERHRGDQSRVRRPETLRSSS--RNEHGIKSDSSKTDKLERKHRHESGDSRERPSS 883 D R + R R P RS S R + S + +R R S R S Sbjct: 429 DASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSR 488 Query: 884 GEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPS 943 G ++ R S +VK+ S S+ + + +S DD + + + D + + Sbjct: 489 GGRRRRSRS-KVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQ--- 544 Query: 944 YLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVV 1003 + ++ K K E M + EP + P Sbjct: 545 ----------RQAIVQKYK------YLAEDSNMSVPSEPSSPQS-----STRTRSPSPDD 583 Query: 1004 VLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPS-KSNKGSIDQSVLKELPPELLAE 1058 +L++++ DV++ ++ D +S+K N + + N GS S K L P++ E Sbjct: 584 ILERVAA-DVKEYERENVDTFEASVKAKHNLMTVEQNNGS---SQKKLLAPDMFTE 635 Score = 61.2 bits (147), Expect = 1e-08 Identities = 128/616 (20%), Positives = 218/616 (35%), Gaps = 131/616 (21%) Query: 641 ETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRP 700 ET+ + E++ S + ++N + QN++ K + ++ + + + + Sbjct: 5 ETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEED 64 Query: 701 ETPKQKGESRPETPKQK-------SDGHPETPKQKGDG---RPETPKQKGESRPETPKQK 750 + K K + + + K+K +G + K D + KQ+ + E + Sbjct: 65 KDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDDLALLEDLEKQRALIKAELDNEL 124 Query: 751 NEGRPET--------------------PKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDS 790 EG+ ++ K R+ NR + ST+ K E+ +K TK Sbjct: 125 MEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTKGKLELVDNKITTKK-- 182 Query: 791 PRLKSERAEALKQRPDGRS-------VSESLRRDHDNKQKSDDRGESERHRGDQSRVRRP 843 R KS E + R D + V E R ++K DQ+R + Sbjct: 183 -RSKSRSKERTRHRSDKKKSKGGIEIVKEKTTRSKSKERKKSKSPSKRSKSQDQARKSKS 241 Query: 844 ETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKS 903 TLR S+ + G K+ S DK++ + + +S D ++ P E +SR +G ++S Sbjct: 242 PTLRRRSQEKIG-KARSPTDDKVKIEDKSKSKDRKKSPIINESRSR------DRGKKSRS 294 Query: 904 RSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKR 963 D G K + +S+ D K + PS K+ K R Sbjct: 295 PVDLRGKSKDRRSRSKERKSKRSETDKEK----KPIKSPS----------KDASSGKENR 340 Query: 964 DKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDK 1023 + K+ + +P+D K Sbjct: 341 SPSRRPGRSPKRRSLSPKPRD--------------------------------------K 362 Query: 1024 SRSSLKPIKN-KPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEK 1082 SR S P+ N + SK +K S + L P A+ S +RKR + Sbjct: 363 SRRSRSPLLNDRRSKQSK-----SPSRTLSPGRRAKSRSL----------ERKR----RE 403 Query: 1083 PKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSG 1142 P+ +SS D+ SR+ KD + RRS RR S R S Sbjct: 404 PERRRLSSPRTRPRDDIL--SRRERSKDASPINRWSPTRRRSRSPIRR--RSRSPLRRSR 459 Query: 1143 GGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRF 1202 R R+RSP D S S + R+ + + +++R + K E+ S + Sbjct: 460 SPRRRSRSPRRRD----RGRRSRSRLRRRSRSRGGRRRRSRSKVK---EDKFKGSLSEGM 512 Query: 1203 TASIENIL-DNLEDMD 1217 E+ DNLED D Sbjct: 513 KVEQESSSDDNLEDFD 528 Score = 57.8 bits (138), Expect = 1e-07 Identities = 83/418 (19%), Positives = 163/418 (38%), Gaps = 43/418 (10%) Query: 793 LKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRN 852 + + ++L+++P+ + + +N + S+D+ +++ SR ++ + S Sbjct: 1 MAAAETQSLREQPEMEDANSEKSINEENGEVSEDQSQNKH-----SRHKKKKHKHRSKHK 55 Query: 853 EHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKS 912 +H S+ K K + KH+H+ +E + +++ + R K D + Sbjct: 56 KHKHSSEEDKDKKHKHKHKHKKHKRKEIIDASDKEGMSPAKRTKLDD-----------LA 104 Query: 913 PTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQE 972 +K+ K+++D ++ L G SG+ + I ++ ++GN Sbjct: 105 LLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIH--EKARNGN-RSS 161 Query: 973 TKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDRED--KSRSSLKP 1030 T+ KG K+ LV+ NK + +K S ++ + R D KS+ ++ Sbjct: 162 TRSSSTKG-------KLELVD--NK-----ITTKKRSKSRSKERTRHRSDKKKSKGGIEI 207 Query: 1031 IKNKP--SKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNK--RKRSTVNEKPKYA 1086 +K K SKS + +S K + A +S P R K + RS ++K K Sbjct: 208 VKEKTTRSKSKERKKSKSPSKRSKSQDQAR-KSKSPTLRRRSQEKIGKARSPTDDKVKIE 266 Query: 1087 EISSDEDNDSDEAFESSRKRHKKDDDKA---WEYEERDRRSSGDHRRSGHSHEGRRSSGG 1143 + S +D SR R + ++ + +DRRS R+S S + Sbjct: 267 DKSKSKDRKKSPIINESRSRDRGKKSRSPVDLRGKSKDRRSRSKERKSKRSETDKEKKPI 326 Query: 1144 GRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKR 1201 + S + S P S R + K + K R++ P L S + R Sbjct: 327 KSPSKDASSGKENRSPSRRPGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSKSPSR 384 >gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] Length = 1564 Score = 79.3 bits (194), Expect = 5e-14 Identities = 164/884 (18%), Positives = 327/884 (36%), Gaps = 109/884 (12%) Query: 261 SSTMRNAASFPLRSPQPVCSPAGSEG--TPKGSRPPLILQSQSLPCSS----------PR 308 S ++R ++ P R P S A + T S P L Q S S P Sbjct: 209 SPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPP 268 Query: 309 DVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSS 368 +P DI L +K K++ K+K +EK + K D K + + S Sbjct: 269 PIPEDIALG---KKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHS 325 Query: 369 DMDQQEDMISGVENSNVSEND-IPFNVQYPGQTSKTPITPQDINRPLNA--AQCLSQQEQ 425 + + S S++ + P + P + + +TP + R + + LS ++ Sbjct: 326 PISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPP-LRRSASPYPSHSLSSPQR 384 Query: 426 TAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESA 485 P ++ P+ ++ + ++ SQ E D + +R E++S Sbjct: 385 KQSPPRHRSPMREKGR------------HDHERTSQSHDRRHERREDTRGKRDR-EKDSR 431 Query: 486 IERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDL 545 ERE + +D + D P++ G +R +++T R L S D+ Sbjct: 432 EEREYEQDQSSSRD-----HRDDREPRD-----GRDRRDARDTRD-----RRELRDSRDM 476 Query: 546 HQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSD 605 + + + T++S + P + + DA + +K D Sbjct: 477 RDSREMRDYSRDTKES---RDPRDSRSTRDA-------------HDYRDREGRDTHRKED 520 Query: 606 PELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNE 665 +S ES E R +E++ E++ E + + + ++ R E + Sbjct: 521 TYPEESRSYGRNHLREESSRTEIR------NESRNESRSEIRNDRMGRSRGRVPELPEKG 574 Query: 666 STIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETP 725 S Q ++ S++ +D+ + PE + ++R + +++ Sbjct: 575 SRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDN-RDQARDSSFERRHGERDRRD 633 Query: 726 KQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQ- 784 ++ D RP +P + E +++E R E R D+RRD +++ E + ++ Sbjct: 634 NRERDQRPSSPIRHQGRNDEL--ERDERREERRVDRVDDRRDERARERDRERERDRERER 691 Query: 785 DTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPE 844 + + + R + + E ++R R RD + + D E ER R ++ R + E Sbjct: 692 ERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERER-ERDREKERE 750 Query: 845 TLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRP-DSPRVKQGDSNKS 903 R E + + + + ER+ E RER E K + D R K+ + + Sbjct: 751 REREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIRED 810 Query: 904 RSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGG----RSGALKNFVIP 959 R+ + G SK R EG+ S + K ++ + +Y G + L V P Sbjct: 811 RNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRP 870 Query: 960 KIKR---------DKDGNVTQETKKMEMKGEPK--DKVEKIGLVEDLNKGAKPVVVLQKL 1008 + R D+ G +E +K E K + ++ E V ++K + +L+ Sbjct: 871 QESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESS 930 Query: 1009 SLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCER 1068 + Q +I + + R + ++ K K I + +K+ + + Sbjct: 931 RMR-AQDIIGHHQSEDRETSDRAHDENKK--KAKIQKKPIKKKKEDDVGI---------- 977 Query: 1069 VKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDD 1112 +R + + ++ S + ++ E RK+ K D D Sbjct: 978 ------ERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSD 1015 Score = 72.0 bits (175), Expect = 7e-12 Identities = 137/721 (19%), Positives = 254/721 (35%), Gaps = 96/721 (13%) Query: 481 ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540 ER + RER + QD D +KR + + P +E+ + + + Sbjct: 79 ERPTGDLRERMKNKRQDVDTEPQKRNTEE----------SSSPVRKESSRGRHREKEDIK 128 Query: 541 VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600 ++ + ++ T DS ++ + + ++ I L + + E Sbjct: 129 ITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKR 188 Query: 601 -----KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEEL--KQ 653 KK+ PE+ +S++ S S SK + + SS +K + K + L +Q Sbjct: 189 EEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQ 248 Query: 654 NESRTTECKQNESTIVEPKQ--------NENRLSDTKPNDNKQNNGRSETTKSRPETPKQ 705 S+T + K+ P + K D + R + R ++ Sbjct: 249 RNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQR 308 Query: 706 KGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNR 765 + +P + H + ++ P +P++K P + Sbjct: 309 EKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSP-SPRRKRTPSPSYQRTLTPPL 367 Query: 766 RDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSD 825 R S P P S K PR +S E K R D S+S R H+ ++ D Sbjct: 368 RRSASP----YPSHSLSSPQRKQSPPRHRSPMRE--KGRHDHERTSQSHDRRHERRE--D 419 Query: 826 DRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGE 885 RG+ +R + D R E +SSSR+ + D D +R+ ++ D RE S + Sbjct: 420 TRGKRDREK-DSREEREYEQDQSSSRDH---RDDREPRDGRDRRDARDTRDRRELRDSRD 475 Query: 886 QKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYL 945 + DS + R S+D K + + T AH E Sbjct: 476 MR-----------DSREMRD--------YSRDTKESRDPRDSRSTRDAHDYRDRE----- 511 Query: 946 LGGRSGALKNFVIPKIKRDKDGN-VTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVV 1004 GR K P+ R N + +E+ + E++ E ++ Sbjct: 512 --GRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRN-------------------- 549 Query: 1005 LQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMP 1064 + ++ DR +SR + + K S+ ++GS S E S+ P Sbjct: 550 ------ESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYP 603 Query: 1065 LCERV--KMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDR 1122 +R + N+ + + + ++ E ++ + D+ SS RH+ +D+ E R+ Sbjct: 604 ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQR-PSSPIRHQGRNDELERDERREE 662 Query: 1123 R--SSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKK 1180 R D RR + E R R R R + L + +++E++K+ Sbjct: 663 RRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKE 722 Query: 1181 R 1181 R Sbjct: 723 R 723 Score = 50.1 bits (118), Expect = 3e-05 Identities = 95/497 (19%), Positives = 178/497 (35%), Gaps = 62/497 (12%) Query: 441 TSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIE-RERFSKEVQDKD 499 +SV ++ QT ++++ + +Q D + + +RE++ + K+ + + Sbjct: 915 SSVDKQREQTEILESSRMRAQ----------DIIGHHQSEDRETSDRAHDENKKKAKIQK 964 Query: 500 KPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQ 559 KP+KK+K+D G GN + E G + + Q Sbjct: 965 KPIKKKKEDDV-----GIERGNIETTSEDGQVFSPKKG---------------------Q 998 Query: 560 DSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESR 619 SI+K + K D+ +S D + +S + P TP + EL EM ++ Sbjct: 999 KKKSIEKKRK-KSKGDSDIS----DEEAAQQSKKKRGPRTPPITTKEELV--EMCNGKNG 1051 Query: 620 LAE-SKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRL 678 + E S+ E+ S E+ + T+ E + + S + P Sbjct: 1052 ILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATAT 1111 Query: 679 SDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQ---KSDGHPETPKQKGDGRPET 735 + T P + T+ S + T D H + + + + + ET Sbjct: 1112 ATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVE-KVET 1170 Query: 736 PKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKS 795 P E + +R + SG+ + + D L S Sbjct: 1171 PHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHS 1230 Query: 796 -----ERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSS 850 E+ ++L+ + +S + L+R ++ S DR +S H SR PE S Sbjct: 1231 GSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSH---SSRRSSPE----SD 1283 Query: 851 RNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGF 910 R H D+L+ + R+E RER ++ D K N+ R D+L Sbjct: 1284 RQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDR-DRLRE 1342 Query: 911 KSPTSKDDKRTEGNKSK 927 + + DKR + ++ + Sbjct: 1343 RERERERDKRRDLDRER 1359 Score = 49.3 bits (116), Expect = 5e-05 Identities = 96/452 (21%), Positives = 166/452 (36%), Gaps = 48/452 (10%) Query: 721 HPETPKQKGDGR-----PETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEK 775 H +P+ KG PE P R + +Q + P+ +R++ + S+ Sbjct: 61 HGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQ--------KRNTEESSSPV 112 Query: 776 KPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRG 835 + E S+ + K D K E+ ++ + E+ R D DN + D Sbjct: 113 RKESSRGRHREKEDIKITKERTPESEEENVEW----ETNRDDSDNGDINYDYVHELSLEM 168 Query: 836 DQSRVRRP----ETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD 891 + +++R E R E IK + S ++ R S R+ S ++KS P Sbjct: 169 KRQKIQRELMKLEQENMEKREEIIIKKEVSP--EVVRSKLSPSPSLRKSSKSPKRKSSPK 226 Query: 892 SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSG 951 S + D S SP + ++ N+SK + P P + G+ Sbjct: 227 SSSASKKDRKTS-----AVSSPLLDQQRNSKTNQSKKKGPRT-PSPPPPIPEDIALGKKY 280 Query: 952 ALKNFVIPKIK-RDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSL 1010 K V +I+ + +DG + E + E +DK + P+ S Sbjct: 281 KEKYKVKDRIEEKTRDGK--DRGRDFERQREKRDKPRS---TSPAGQHHSPISSRHHSSS 335 Query: 1011 DDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVK 1070 I+ R K PS S + ++ + + P + S +R + Sbjct: 336 SQSGSSIQRHSPSPRR-----KRTPSPSYQRTLTPPLRRSASPYPSHSLSSP----QRKQ 386 Query: 1071 MNKRKRSTVNEKPKYAEISSDEDNDS-DEAFESSRKRHKKDDDKAWEYE-ERDRRSSGDH 1128 R RS + EK ++ + + +D E E +R + ++ D E E E+D+ SS DH Sbjct: 387 SPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDH 446 Query: 1129 RRSGHSHEG--RRSSGGGRYRNRSPSDSDMED 1158 R +G RR + R R DM D Sbjct: 447 RDDREPRDGRDRRDARDTRDRRELRDSRDMRD 478 Score = 42.7 bits (99), Expect = 0.005 Identities = 41/180 (22%), Positives = 78/180 (43%), Gaps = 21/180 (11%) Query: 1015 KLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAE-IESTMPLCERVKMNK 1073 K+ K+R +S + S+ G I+ + EL E+ + I+ + E+ M K Sbjct: 128 KITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEK 187 Query: 1074 RKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSG------D 1127 R+ + +K E+ + + S +SS+ +K K+ ++DR++S D Sbjct: 188 REEIII-KKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLD 246 Query: 1128 HRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPK 1187 +R+ +++ ++ R+PS PPP ++A K KEK K + E K Sbjct: 247 QQRNSKTNQSKKKGP------RTPSP-------PPPIPEDIALGKKYKEKYKVKDRIEEK 293 Score = 41.2 bits (95), Expect = 0.014 Identities = 76/343 (22%), Positives = 121/343 (35%), Gaps = 46/343 (13%) Query: 828 GESERHRGDQSRVRR-PETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQ 886 G S R +G S RR PE R K T+ +R S R+ S G Sbjct: 62 GPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRH 121 Query: 887 KSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLL 946 + + D K+ ++P S+++ + +TN+ DN Y+ Sbjct: 122 REKEDIKITKE-------------RTPESEEEN------VEWETNRDDSDNGDINYDYV- 161 Query: 947 GGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQ 1006 + + ++KR K + +E K+E E +K E+I + K P VV Sbjct: 162 --------HELSLEMKRQK---IQRELMKLEQ--ENMEKREEI----IIKKEVSPEVVRS 204 Query: 1007 KLS----LDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQ---SVLKELPPELLAEI 1059 KLS L K K + SS K S + +DQ S + + Sbjct: 205 KLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTP 264 Query: 1060 ESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEE 1119 P+ E + + K+ + K + E + D D FE R++ K + + Sbjct: 265 SPPPPIPEDIALGKKYKEKYKVKDRIEEKTRD-GKDRGRDFERQREKRDKPRSTSPAGQH 323 Query: 1120 RDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPP 1162 SS H S S + R R+PS S +PP Sbjct: 324 HSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPP 366 >gi|6631100 natural killer-tumor recognition sequence [Homo sapiens] Length = 1462 Score = 77.8 bits (190), Expect = 1e-13 Identities = 140/669 (20%), Positives = 247/669 (36%), Gaps = 75/669 (11%) Query: 589 LKSTPENHPETPKK---KSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVE 645 L+S+ + + + KK S+ L +K + K +E+R SS+++ + Sbjct: 759 LRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQA 818 Query: 646 TQT--EELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETP 703 TQ+ E+ KQ + T KQ ++ E ++E +K K+N S+P+ Sbjct: 819 TQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRK 878 Query: 704 KQKGES--------RPETPKQKSDGHPETPKQKGDGRPETPKQKGE----SRPETPKQKN 751 G R T K+D HP + K++G+ ++ + E +P T N Sbjct: 879 NYAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTN 938 Query: 752 EGRPE------TPKHRHDNRRDSGKPSTEK--KPEVSKHKQDTKSDSPRLKSERAEALKQ 803 P+ + K R G S + + + KHK +K + LK E + +K+ Sbjct: 939 TSLPDDNGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKEN---LKREHTKKVKE 995 Query: 804 RPDGRSVSE---SLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDS 860 + G+ + R+ + Q + GE E D +V + + S N IK + Sbjct: 996 KLKGKKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNI 1055 Query: 861 SKTDKLERKHRHESGDSRERPSSGEQKSRPD-----SPRVKQGDSNKSRSDKLGF---KS 912 KT+K + D+ S +Q ++ D SP + N + + Sbjct: 1056 LKTEKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSISPTALNTEENVACLQNIQHVEESV 1115 Query: 913 PTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALK-NFVI--------PKIKR 963 P +D + ++ T K E S L R N V+ P+ + Sbjct: 1116 PNGVEDVLQTDDNMEICTPDRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQAEV 1175 Query: 964 DKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDK 1023 K + E+K + G+ + + + G K V +++L DK Sbjct: 1176 VKQESSMSESKVLGEVGKQDSSSASLASAGE-STGKKEVAEKSQINL----------IDK 1224 Query: 1024 SRSSLKPIKN--KPSKSNKGSIDQSVLKELP---PE-LLAEIESTMPLCERVKMNK-RKR 1076 L+ + N P+ + +++ VL +P P+ L EI+S + ++ RK Sbjct: 1225 KWKPLQGVGNLAAPNAATSSAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKT 1284 Query: 1077 STVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHE 1136 + +N +P+ E SSDE S + SR + + R R S H RS Sbjct: 1285 ARLNRRPRNQESSSDEQTPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRS----- 1339 Query: 1137 GRRSSGGGRYRNRSPSDSDMEDY---SPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEM 1193 R S YR+RS S S + S S R K + ++ P Sbjct: 1340 -RSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSR 1398 Query: 1194 MDSSTFKRF 1202 S T+ + Sbjct: 1399 SRSYTYDSY 1407 Score = 64.7 bits (156), Expect = 1e-09 Identities = 121/636 (19%), Positives = 222/636 (34%), Gaps = 96/636 (15%) Query: 630 LVETKSSENKLETKVE--TQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNK 687 ++ TKS ++ E K + T +E + + ++ + + + +E +++ R +P + Sbjct: 175 VLATKSIKDVFEKKRKKPTHSEGSDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKR 234 Query: 688 QNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETP 747 R E + S E P+ K P+ ++SD + E ++ E P Sbjct: 235 SKKRRKEASSS--EEPRNKHAMNPKGHSERSDTN------------EKRSVDSSAKREKP 280 Query: 748 KQKNEGRPETPKHRHDNRRDSGKPSTEKKPE-------VSKHKQDTKSDSPRLKSERAEA 800 + E P P++R RRD + E +P+ VS K ++K Sbjct: 281 VVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQKPSVSKSGRKIKGRGTIR 340 Query: 801 LKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDS 860 P RS SES D D+ ++ + E R R RP + S+ + S Sbjct: 341 YHTPPRSRSCSES---DDDDSSETPPHWKEEMQR---LRAYRPPSGEKWSKGDKLSDPCS 394 Query: 861 SKTDKLERKHRHES-------GDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSP 913 S+ D+ R S D SG K R +VK K + K Sbjct: 395 SRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKGKKQKHCRRHKQT 454 Query: 914 TSKD---DKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVT 970 + E +KS K+ D + S L + +++ K +D ++T Sbjct: 455 KKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDW--SKSDKDVQSSLT 512 Query: 971 QETK---------KMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDRE 1021 ++ + +G + + ++ + S +K Sbjct: 513 HSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKS-----RSSSKSGHRKRASKSP 567 Query: 1022 DKSRSSL---KPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRST 1078 K+ S L KP+K +P ++ + V++ ++AE +PL + ++ K Sbjct: 568 RKTASQLSENKPVKTEPLRATMAQNENVVVQ----PVVAENIPVIPLSDSPPPSRWKPGQ 623 Query: 1079 VNEKPKYAEI--------------------------SSDEDNDSDEAFESSRKRHKKDDD 1112 KP Y I SS + ++ ES + + K D Sbjct: 624 KPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNSESDQSTYSKYSD 683 Query: 1113 KAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSD--------SDMEDYSPPPS 1164 ++ E R R S R S+ RS R+RSPS SD S S Sbjct: 684 RSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSS 743 Query: 1165 LSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFK 1200 + ++ ++ K++ R + + + SS+ K Sbjct: 744 YTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEK 779 Score = 64.7 bits (156), Expect = 1e-09 Identities = 184/862 (21%), Positives = 329/862 (38%), Gaps = 92/862 (10%) Query: 118 QSGMMMSQYKLSQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSP 177 ++G S +K +NS S Y + SP SR ++ S +R + S S Sbjct: 657 ETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSH 716 Query: 178 YAPQSPAGYMPYSHP-SSYTTHPQMQQASVSSPIVA-GGLRNIHDNKVSGPLSGNSANHH 235 +SP+ SH + Y+ H Q ++S + I + G R + SG + S H Sbjct: 717 SRSRSPSS---RSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKH 773 Query: 236 ADNPRHGSSEDYLHMVHRLSSDDGDSSTMR----NAASFPLRSPQPVCSPAGSEGTPKGS 291 + SSE LH + D SS +R + +S S S ++ + Sbjct: 774 S-----SSSEKTLHSKYVKGRD--RSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKE 826 Query: 292 RPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKK-----MKLGKDEKEQSEKAAMYD 346 + + ++ + + + + P K++ K+ ++ G K ++ + +D Sbjct: 827 KQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWD 886 Query: 347 IISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPIT 406 S+ +D TK + S S D++E + S VSE I V+ ++S Sbjct: 887 SESNSERDVTKNSKNDSHPSS---DKEEGEATSDSESEVSE--IHIKVKPTTKSSTNTSL 941 Query: 407 PQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIY 466 P D N A S+Q + + N K S +++ +++ + Sbjct: 942 PDD-----NGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKK--VK 994 Query: 467 DEVELDALAEIERIERESAIERE---RFSKEVQDK--DKPLKKRKQDSYPQEAGGATGGN 521 ++++ + + +R+ A + F +E +++ DK + + ++ E N Sbjct: 995 EKLKGKKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDN 1054 Query: 522 RPASQETGSTG-NGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSV 580 ++++ +G + VS DL Q + DS+ SI S + EE C Sbjct: 1055 ILKTEKSSEEDLSGKHDTVTVSSDLDQFTKDDSKLSI---SPTALNTEENVAC------- 1104 Query: 581 LQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKL 640 ++I +S P + + + E+ + + S +++ E+ P N ++T L Sbjct: 1105 -LQNIQHVEESVPNGVEDVLQTDDNMEICTPD-RSSPAKVEETSPLGNARLDTPDINIVL 1162 Query: 641 ETKVET---QTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTK 697 + + T Q E +KQ ES +E K + + + S + K+ +S+ Sbjct: 1163 KQDMATEHPQAEVVKQ-ESSMSESKVLGEVGKQDSSSASLASAGESTGKKEVAEKSQINL 1221 Query: 698 SRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRP-- 755 + +G P + E P+ K + K KN+ RP Sbjct: 1222 IDKKWKPLQGVGNLAAPNAATSSAVEVKV-----LTTVPEMKPQGLRIEIKSKNKVRPGS 1276 Query: 756 ---ETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSE 812 E K NRR + S+ + S+ D++S SP ++E K R RSVS Sbjct: 1277 LFDEVRKTARLNRRPRNQESSSDEQTPSR-DDDSQSRSPSRSRSKSET-KSRHRTRSVSY 1334 Query: 813 SLRRDHDNKQKSDDRGES---ERHRGDQSRVR---RPETLRS--SSRNEHGIKSDSSKTD 864 S R S R S R RG SR R R + RS S R +S SS D Sbjct: 1335 SHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYD 1394 Query: 865 --KLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTE 922 R + ++S SR R S Q+S DS + + +SRS R+ Sbjct: 1395 PHSRSRSYTYDSYYSRSRSRSRSQRS--DSYHRGRSYNRRSRS-------------CRSY 1439 Query: 923 GNKSKVDTNKAHPDNKAEFPSY 944 G+ S+ D + +H + +E Y Sbjct: 1440 GSDSESDRSYSHHRSPSESSRY 1461 Score = 57.8 bits (138), Expect = 1e-07 Identities = 159/812 (19%), Positives = 276/812 (33%), Gaps = 119/812 (14%) Query: 470 ELDALAEIERIERESAIERERFSK--EVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQE 527 E + + + E+ S ++ +SK + + P + + + T AS Sbjct: 657 ETGSSSSYHKREKNSESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSH 716 Query: 528 TGSTGNGSRPALMVSIDLH-QAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIV 586 + S SR H Q R S SI+ SD ++ + + + SV + Sbjct: 717 SRSRSPSSRSHSRNKYSDHSQCSRSSSYTSIS--SDDGRRAKRRLRSSGKKNSVSHKKHS 774 Query: 587 GSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVET 646 S + T + + +S SE S S L S +E V+ S + E + + Sbjct: 775 SSSEKTLHSKYVKGRDRSSCVRKYSE---SRSSLDYSSDSEQSSVQATQSAQEKEKQGQM 831 Query: 647 QTEELKQNESRTTECKQNESTIVEPKQN--ENRLSDTKPNDNK-------------QNNG 691 + KQ ++R E ++E K+ + LSD N +K ++N Sbjct: 832 ERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNS 891 Query: 692 RSETTK-----SRPETPKQKGESRPETPKQKSDGHPET-PKQKGDGRPETPKQKG---ES 742 + TK S P + K++GE+ ++ + S+ H + P K P G S Sbjct: 892 ERDVTKNSKNDSHPSSDKEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSS 951 Query: 743 RPETPKQKNEG--------RPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLK 794 + T +EG R + KH+H ++ + + T+K E K K+D K +P+ K Sbjct: 952 KQRTSTSDSEGSCSNSENNRGKPQKHKHGSKENLKREHTKKVKEKLKGKKDKKHKAPKRK 1011 Query: 795 S------------ERAEALK-----QRPDGRSVSESLRRDHDN---KQKSDDRGESERH- 833 E E + Q + VSE+ DN +KS + S +H Sbjct: 1012 QAFHWQPPLEFGEEEEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKHD 1071 Query: 834 -----------RGDQSRVRRPETLRSSSRN--------------EHGIKSDSSKTDKLER 868 D S++ T ++ N +G++ D +E Sbjct: 1072 TVTVSSDLDQFTKDDSKLSISPTALNTEENVACLQNIQHVEESVPNGVEDVLQTDDNMEI 1131 Query: 869 KHRHESGDSRERPSSGEQKSRPDSPRVK---QGDSNKSRSDKLGFKSPTSKDDKRTEGNK 925 S ++ +S +R D+P + + D K +S + + G Sbjct: 1132 CTPDRSSPAKVEETSPLGNARLDTPDINIVLKQDMATEHPQAEVVKQESSMSESKVLGEV 1191 Query: 926 SKVDTNKAHPDNKAEFPSYLLGGRSGALK-------------NFVIPKIKRDKDGNVTQE 972 K D++ A + E + N P V Sbjct: 1192 GKQDSSSASLASAGESTGKKEVAEKSQINLIDKKWKPLQGVGNLAAPNAATSSAVEVKVL 1251 Query: 973 TKKMEMKGE-------PKDKVEKIGLVEDLNKGAK----PVVVLQKLSLDDVQKLIKDRE 1021 T EMK + K+KV L +++ K A+ P + S D Q +D + Sbjct: 1252 TTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRRP---RNQESSSDEQTPSRDDD 1308 Query: 1022 DKSRSSLKPIKNKPSKSNKG--SIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTV 1079 +SRS + +KS S+ S + + S R + + T Sbjct: 1309 SQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYRSRSYSRSRSRGWYSRGRTR 1368 Query: 1080 NEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRR 1139 + Y S + + SS H + ++ RS +RS H GR Sbjct: 1369 SRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRSRSRSQRSDSYHRGRS 1428 Query: 1140 SSGGGRYRNRSPSDSDME-DYSPPPSLSEVAR 1170 + R SDS+ + YS S SE +R Sbjct: 1429 YNRRSRSCRSYGSDSESDRSYSHHRSPSESSR 1460 Score = 57.0 bits (136), Expect = 2e-07 Identities = 113/585 (19%), Positives = 215/585 (36%), Gaps = 53/585 (9%) Query: 583 EDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLET 642 +D+ SL + + + S + + + S+ +KS K + Sbjct: 505 KDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSRSKSRSSSKSGHRKRAS 564 Query: 643 KVETQT-EELKQNESRTTE-----CKQNESTIVEPKQNEN----RLSDTKPNDNKQNNGR 692 K +T +L +N+ TE QNE+ +V+P EN LSD+ P ++ G+ Sbjct: 565 KSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLSDSPP-PSRWKPGQ 623 Query: 693 SETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNE 752 S + K ++ P Q + K+ G S ++KN Sbjct: 624 KPWKPSYERIQEMKAKTTHLLPIQSTYSLANI------------KETGSSSSYHKREKNS 671 Query: 753 GRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSE 812 ++ ++ +R P + + S+ + + S L S + + + P RS S Sbjct: 672 ESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRS--RSPSSRSHSR 729 Query: 813 SLRRDHDNKQKSDDRG--ESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKH 870 + DH +S S+ R + R+R S S +H S+ + K K Sbjct: 730 NKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYV-KG 788 Query: 871 RHESGDSR---ERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSK 927 R S R E SS + S + V+ S + + + + +K +K KSK Sbjct: 789 RDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSK 848 Query: 928 VDTNKAHPDN---KAEFPSYLLGGRSGALKNFVIPK------IKRDKDGNVTQETKKMEM 978 + H K +L G KN+ K +RD N ++ Sbjct: 849 SERECPHSKKRTLKENLSDHLRNGSKPKRKNYAGSKWDSESNSERDVTKNSKNDSHPSSD 908 Query: 979 KGEPKDKVEKIGLVEDLNKGAKPVVVLQ-KLSLDD--------VQKLIKDREDKSRSSLK 1029 K E + + V +++ KP SL D Q+ + S S+ + Sbjct: 909 KEEGEATSDSESEVSEIHIKVKPTTKSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSNSE 968 Query: 1030 PIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKP-KYAEI 1088 + KP K GS +++ +E ++ +++ ++ K KRK++ + P ++ E Sbjct: 969 NNRGKPQKHKHGS-KENLKREHTKKVKEKLKGKKD--KKHKAPKRKQAFHWQPPLEFGEE 1025 Query: 1089 SSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGH 1133 +E +D ES K+ ++++ + + +SS + H Sbjct: 1026 EEEEIDDKQVTQESKEKKVSENNETIKDNILKTEKSSEEDLSGKH 1070 Score = 49.7 bits (117), Expect = 4e-05 Identities = 129/651 (19%), Positives = 220/651 (33%), Gaps = 90/651 (13%) Query: 595 NHPETPKKKSDPELS-KSEMKQSESRLAESKPNENRLVETKSSE---NKLETKVETQTEE 650 N + + S+ EL + ++ R + K ++ R E SSE NK + +E Sbjct: 203 NSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNKHAMNPKGHSER 262 Query: 651 LKQNESRTTECK-QNESTIVEPKQ----NENR------------------------LSDT 681 NE R+ + + E +V P++ ENR +SD Sbjct: 263 SDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSDQ 322 Query: 682 KPNDNKQNN---GRSETTKSRPETPKQKGES------------RPETPKQKSDGHPETPK 726 KP+ +K GR P + ES + E + ++ P K Sbjct: 323 KPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYRPPSGEK 382 Query: 727 -QKGDGRPETPKQKGESRPETPKQKNEGRP------ETPKH--RHDNRRDSGKPSTEKKP 777 KGD + + + R + + ++ T +H H RR K +KK Sbjct: 383 WSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKKVKHKKKG 442 Query: 778 EVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQ 837 + KH + K R ++ + R + S R+ ++ S S + + Sbjct: 443 KKQKHCRRHKQTKKRRILIPSDIESSKSSTRRMKSSCDRERSSRSSSLSSHHSSKRDWSK 502 Query: 838 SRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQ 897 S +L SSR+ + KS S + G SR R +S + S R K Sbjct: 503 SDKDVQSSLTHSSRDSYRSKSHSQS---------YSRGSSRSRTAS--KSSSHSRSRSKS 551 Query: 898 GDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKA-HPDNKAEFPSYLLGGRSGALKNF 956 S+KS K KSP + +E K + +A N+ ++ + Sbjct: 552 RSSSKSGHRKRASKSPRKTASQLSENKPVKTEPLRATMAQNENVVVQPVVAENIPVIPLS 611 Query: 957 VIPKIKRDKDGNVTQE---TKKMEMKGEPKDKV---EKIGLVEDLNKGAKPVVVLQKLSL 1010 P R K G + + EMK + + L G+ ++ + Sbjct: 612 DSPPPSRWKPGQKPWKPSYERIQEMKAKTTHLLPIQSTYSLANIKETGSSSSYHKREKNS 671 Query: 1011 DDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVK 1070 + Q D+S S +++ S+S S + + L + S P Sbjct: 672 ESDQSTYSKYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLAS---SHSRSRSPSSRSHS 728 Query: 1071 MNK-RKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHR 1129 NK S + Y ISSD+ + SS K++ ++ S Sbjct: 729 RNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVS----------HKKHSSSSE 778 Query: 1130 RSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKK 1180 ++ HS + R S S S + DYS S V +EK+K+ Sbjct: 779 KTLHSKYVKGRDRSSCVRKYSESRSSL-DYSSDSEQSSVQATQSAQEKEKQ 828 >gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] Length = 494 Score = 76.6 bits (187), Expect = 3e-13 Identities = 82/349 (23%), Positives = 150/349 (42%), Gaps = 27/349 (7%) Query: 602 KKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTEC 661 K++ +L +E+ + RL E KP R S ++ ++ +++ +++ SR+ Sbjct: 154 KRALEKLDGTEVNGRKIRLVEDKPGSRR--RRSYSRSRSHSRSRSRSRHSRKSRSRSGSS 211 Query: 662 KQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETP---KQKS 718 K + S ++ +R S +K Q+ RS+ KSR + K+K SR + + KS Sbjct: 212 KSSHSKSRSRSRSGSR-SRSKSRSRSQSRSRSKKEKSRSPS-KEKSRSRSHSAGKSRSKS 269 Query: 719 DGHPETPKQKGD--GRPETPK-QKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEK 775 E Q D G+P++ + +S+ ++ + E R E K +R S + S + Sbjct: 270 KDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQ 329 Query: 776 KPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRG 835 S+ K ++S S R +S+ + K R R S S R ++S RG + Sbjct: 330 SRSRSRSKGGSRSRS-RSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKA 388 Query: 836 DQSRVRRPE-TLRSSSRN---------EHGIKSDSSKTDKLERKHRHESGDSRERPSSGE 885 S+ ++ E T RS SR+ EH S + + E ++ + ++R R S Sbjct: 389 GSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSR-SRSN 447 Query: 886 QKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAH 934 KS+P+ P ++SRS SK R+ +++H Sbjct: 448 SKSKPNLP-----SESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSH 491 Score = 66.2 bits (160), Expect = 4e-10 Identities = 76/325 (23%), Positives = 139/325 (42%), Gaps = 34/325 (10%) Query: 594 ENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQ 653 E+ P + +++S S+S + S SR S+ + +R +KSS +K ++ + + + Sbjct: 174 EDKPGSRRRRSYSR-SRSHSR-SRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSK 231 Query: 654 NESRT---TECKQNESTIVEPKQNENRLSDTKPNDNK---------QNNGRSETTKSR-P 700 + SR+ + K+ +S +++ +R + +K QNN KSR P Sbjct: 232 SRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSP 291 Query: 701 ETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQ-------KGESRPET-----PK 748 K K +SR + +++ + +G + ++ +Q KG SR + K Sbjct: 292 SRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSK 351 Query: 749 QKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKS-DSPRLKSERAEALKQRPDG 807 K +GR + R ++R S S ++ K+D+K+ S + K E + + R Sbjct: 352 DKRKGRKRS---REESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPS 408 Query: 808 RSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLE 867 RSVS+ + + RGESE +Q R RS+S+++ + S+S K Sbjct: 409 RSVSKEREHAKSESSQREGRGESENAGTNQETRSRS---RSNSKSKPNLPSESRSRSKSA 465 Query: 868 RKHRHESGDSRERPSSGEQKSRPDS 892 K R S S +SR S Sbjct: 466 SKTRSRSKSRSRSASRSPSRSRSRS 490 Score = 63.9 bits (154), Expect = 2e-09 Identities = 58/293 (19%), Positives = 129/293 (44%), Gaps = 22/293 (7%) Query: 591 STPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEE 650 S+ +H ++ + S+S+ + + SK ++R + S ++ + +++++ Sbjct: 210 SSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKS 269 Query: 651 LKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESR 710 Q E + QN + +PK S + ++ RS + + R E K+ SR Sbjct: 270 KDQAEEKI----QNNDNVGKPK------SRSPSRHKSKSKSRSRSQERRVEEEKRGSVSR 319 Query: 711 PETPKQKSDGHPETPKQKGDGRPET-------PKQKGESRP-ETPKQKNEGRPETPKHR- 761 + ++ + KG R + K+KG R E + ++ R ++ + R Sbjct: 320 GRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRK 379 Query: 762 HDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSER--AEALKQRPDGRSVSESLRRDHD 819 ++RDS S++KK + + ++S S + ER A++ + +GR SE+ + + Sbjct: 380 RGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQE 439 Query: 820 NKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRH 872 + +S +S+ + +SR R ++ SR++ +S +S++ R H Sbjct: 440 TRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRS-ASRSPSRSRSRSH 491 Score = 48.5 bits (114), Expect = 9e-05 Identities = 61/312 (19%), Positives = 108/312 (34%), Gaps = 33/312 (10%) Query: 741 ESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEA 800 E +P + ++++ R + R S K + S H + R +S Sbjct: 174 EDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKS------RSRSRSGSR 227 Query: 801 LKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGI---K 857 + + RS S S + ++ S ++ S H +SR + + +N + K Sbjct: 228 SRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPK 287 Query: 858 SDSSKTDKLERKHRHESGDSR----ERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSP 913 S S K + K R S + R +R S +S+ S R + S + +S Sbjct: 288 SRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSR 347 Query: 914 TSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQET 973 + DKR +S+ ++ S G + + K K D D + ++ Sbjct: 348 SKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSP 407 Query: 974 KKMEMKGEPKDKVE---KIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKP 1030 + K K E + G E N G ++ +SRS+ K Sbjct: 408 SRSVSKEREHAKSESSQREGRGESENAGTN-----------------QETRSRSRSNSKS 450 Query: 1031 IKNKPSKSNKGS 1042 N PS+S S Sbjct: 451 KPNLPSESRSRS 462 Score = 47.4 bits (111), Expect = 2e-04 Identities = 72/330 (21%), Positives = 119/330 (36%), Gaps = 29/330 (8%) Query: 857 KSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSK 916 K S + R H SR R S +KSR S K S + G +S + Sbjct: 176 KPGSRRRRSYSRSRSHSRSRSRSRHS---RKSRSRSGSSKSSHSKSRSRSRSGSRSRSKS 232 Query: 917 DDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKM 976 + ++SK + +++ K+ S+ G K+ KI+ + + + Sbjct: 233 RSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPS 292 Query: 977 EMKGEPKDKVE-KIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKP 1035 K + K + + VE+ +G+ Q+ SL R+ +SRS K Sbjct: 293 RHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSL---------RQSRSRSRSKGGSRSR 343 Query: 1036 SKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTV--NEKPKYAEISSDED 1093 S+S S D+ ++ E + ER + KR + + K K E + Sbjct: 344 SRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQ 403 Query: 1094 NDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSD 1153 + S S + H K E R G+ +G + E R R+RS S Sbjct: 404 SRSPSRSVSKEREHAKS-------ESSQREGRGESENAGTNQETRS-------RSRSNSK 449 Query: 1154 SDMEDYSPPPSLSEVARKMKKKEKQKKRKA 1183 S S S S+ A K + + K + R A Sbjct: 450 SKPNLPSESRSRSKSASKTRSRSKSRSRSA 479 Score = 46.6 bits (109), Expect = 3e-04 Identities = 79/368 (21%), Positives = 134/368 (36%), Gaps = 41/368 (11%) Query: 803 QRPDGRSVSESLRRDHDNKQKSDDRGESERHRG-DQSRVRRPETLRSSSRNEHGIKSDSS 861 ++ DG V+ R ++K S R R R +SR R + +S SR+ KS S Sbjct: 158 EKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSS-KSSHS 216 Query: 862 KTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRT 921 K+ R SR R S +S+ + R + ++SRS G SKD Sbjct: 217 KSRSRSRSGSRSRSKSRSR-SQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQA-- 273 Query: 922 EGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGE 981 + K+ N DN + S RS + R ++ V +E + +G Sbjct: 274 ---EEKIQNN----DNVGKPKS-----RSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGR 321 Query: 982 PKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKG 1041 ++K + +KG + D +K K ++SRS + +G Sbjct: 322 SQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRG 381 Query: 1042 SIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEA-F 1100 S S + +K+K+ ++ + S + + A Sbjct: 382 SKRDS---------------------KAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKS 420 Query: 1101 ESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGH--SHEGRRSSGGGRYRNRSPSDSDMED 1158 ESS++ + + + A +E RS + + + S RS + R+RS S S Sbjct: 421 ESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSAS 480 Query: 1159 YSPPPSLS 1166 SP S S Sbjct: 481 RSPSRSRS 488 Score = 33.5 bits (75), Expect = 2.9 Identities = 45/200 (22%), Positives = 71/200 (35%), Gaps = 11/200 (5%) Query: 1018 KDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRS 1077 K KSRS + SKS S +S K+ ++ +S K + + Sbjct: 212 KSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKD 271 Query: 1078 TVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEG 1137 EK + + + S +S K + ++ E E+R S G + Sbjct: 272 QAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSR 331 Query: 1138 RRSSGGGRYRNRSPSDSDMEDYSPPPSLSEV-----ARKMKKKEKQKKR------KAYEP 1186 RS G R+RS S S +D S +R K E+ +KR KA Sbjct: 332 SRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGSS 391 Query: 1187 KLTPEEMMDSSTFKRFTASI 1206 K +E D S + + S+ Sbjct: 392 KKKKKEDTDRSQSRSPSRSV 411 Score = 32.7 bits (73), Expect = 5.0 Identities = 33/157 (21%), Positives = 62/157 (39%), Gaps = 11/157 (7%) Query: 1038 SNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKP------KYAEISSD 1091 ++KG ++ V++ + ++++ + + ++N RK V +KP Y+ S Sbjct: 135 AHKGRKNEGVIEFVS---YSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSR-SRS 190 Query: 1092 EDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSP 1151 + S + R + K+ + R R SG RS + S + ++RSP Sbjct: 191 HSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSP 250 Query: 1152 SDSDMEDYSPPPSLSEVARKMKKKEK-QKKRKAYEPK 1187 S S S K + +EK Q +PK Sbjct: 251 SKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPK 287 >gi|217330641 IWS1 homolog [Homo sapiens] Length = 819 Score = 74.3 bits (181), Expect = 1e-12 Identities = 140/695 (20%), Positives = 263/695 (37%), Gaps = 92/695 (13%) Query: 581 LQEDIVGSLKSTPENHPETPKKKSDPELSKSE-MKQSES----RLAESKPNENRLVETKS 635 + E GS + E H E + L K + SE+ L S L K Sbjct: 33 VNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHRQKD 92 Query: 636 SENKLETKVE-----TQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNN 690 S+++ E + E ++ E++ Q+ S +E ++ +NE L+ + ++ Sbjct: 93 SDSESEERAEPPASDSENEDVNQHGS-DSESEETRKLPGSDSENEELLNGHASDSENEDV 151 Query: 691 GRSETTKSRPE----TPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPET 746 G+ + S E +P E+ Q SD E P R + + E P+ Sbjct: 152 GKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPP-----RHQASDSENEEPPK- 205 Query: 747 PKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPD 806 P+ + E PK + S S E + ++ + PR+ +E + Sbjct: 206 PRMSDSESEELPKPQV-----SDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQA 260 Query: 807 GRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRN-EHGIKSDSSKTDK 865 S +E L + + +S+D ++ + + +P S S + G SDS D Sbjct: 261 SDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDA 320 Query: 866 LERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNK 925 K + ES D +R + GE D+ + S D+ F S S+++ E K Sbjct: 321 SRHKQKPESDDDSDRENKGE-----DTEMQNDSFHSDSHMDRKKFHSSDSEEE---EHKK 372 Query: 926 SKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDK 985 K+D+++ + + E K+ + K ++ + + E K Sbjct: 373 QKMDSDEDEKEGEEE-------------------KVAKRKAAVLS------DSEDEEKAS 407 Query: 986 VEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQ 1045 +K +V D + V S + + D E+++ L KN+ K GS + Sbjct: 408 AKKSRVVSDADDSDSDAV--SDKSGKREKTIASDSEEEAGKELSDKKNE-EKDLFGSDSE 464 Query: 1046 SVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRK 1105 S +E L+A+I E + + + E+ ++ ED+DSD+ + R Sbjct: 465 SGNEE--ENLIADIFGESGDEEEEEFTGFNQEDLEEEKGETQVKEAEDSDSDDNIK--RG 520 Query: 1106 RHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSL 1165 +H D ++E + R+ S + RR+ GG + SD+D + + Sbjct: 521 KHM---DFLSDFEMMLQ------RKKSMSGKRRRNRDGGTF----ISDADDVVSAMIVKM 567 Query: 1166 SEVARKMKKKEKQKKRKAYEPKLTP--------EEMMDSSTFKRFTASIENILDNLEDMD 1217 +E A + ++ QKK + L P +++ ++ ++I+ L L D Sbjct: 568 NEAAEEDRQLNNQKKPALKKLTLLPAVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRS 627 Query: 1218 FTAFGDDDEIPQELLLGKHQLNELGSESAKIKAMG 1252 A +I +ELL +L + E+ K +G Sbjct: 628 LPAL----KIREELLKILQELPSVSQETLKHSGIG 658 Score = 63.2 bits (152), Expect = 3e-09 Identities = 104/509 (20%), Positives = 184/509 (36%), Gaps = 63/509 (12%) Query: 456 QQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQE-- 513 + +++Q D ++ +E E +RE + + + + D+PL DS +E Sbjct: 30 EDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTD-SENDEPLNLNASDSESEELH 88 Query: 514 ------AGGATGGNRPASQ-------ETGSTGNGSRPALMVSIDLHQAGRVDSQASITQD 560 + PAS + GS + D ++ AS +++ Sbjct: 89 RQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSEN 148 Query: 561 SDSIKKP---EEIKQCNDAPVS------VLQEDIVGSLKSTPENHPETPKKKSDPELSKS 611 D K P EI++ +P S L+ I S P H + + +P K Sbjct: 149 EDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQASDSENEEP--PKP 206 Query: 612 EMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEP 671 M SES E P + ++ +++S E +++ EEL + +E + Sbjct: 207 RMSDSES---EELP-KPQVSDSESEEPPRHQASDSENEELPKPRISDSESEDPPRHQASD 262 Query: 672 KQNEN----RLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETP-- 725 +NE R+SD++ D +N + P+ ES SD E Sbjct: 263 SENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASR 322 Query: 726 -KQKGDGRPETPKQ-KGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHK 783 KQK + ++ ++ KGE +T Q + ++ R + KK ++ + Sbjct: 323 HKQKPESDDDSDRENKGE---DTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDE 379 Query: 784 QDTKSDSPRLKSERAEALKQRPDGRSVSESLRR------DHDNKQKSDDRGESERHRGDQ 837 + + + ++ +A L D S R D D+ SD G+ E+ Sbjct: 380 DEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASD 439 Query: 838 SRVRRPETLRSSSRNEH----GIKSDS-SKTDKLERKHRHESGDSRERPSSG-------E 885 S + L S +NE G S+S ++ + L ESGD E +G E Sbjct: 440 SEEEAGKEL-SDKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEE 498 Query: 886 QKSRPDSPRVKQGDS--NKSRSDKLGFKS 912 +K + DS N R + F S Sbjct: 499 EKGETQVKEAEDSDSDDNIKRGKHMDFLS 527 Score = 41.2 bits (95), Expect = 0.014 Identities = 71/284 (25%), Positives = 105/284 (36%), Gaps = 59/284 (20%) Query: 133 MHSSPASSNYQQTTISH--SPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYS 190 + SPAS + + + S S PP+ + + +N P P S + +P Sbjct: 164 LQKSPASDSETEDALKPQISDSESEEPPRHQASD----SENEEPPKPRMSDSESEELPKP 219 Query: 191 HPS-SYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLH 249 S S + P QAS S + ++ P +S + D PRH +S+ Sbjct: 220 QVSDSESEEPPRHQASDSE-----------NEELPKPRISDSESE--DPPRHQASDSENE 266 Query: 250 MVHRLSSDDGDSSTM-RNAASFPLRS--PQPVCSPAGSEGTPKG--------------SR 292 + + D +S RN AS P+P S + SEG KG + Sbjct: 267 ELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASRHKQK 326 Query: 293 PP-------------LILQSQSLPCSSPRDVPPDILLDSPERKQKKQKK-----MKLGKD 334 P +Q+ S S D DS E + KKQK K G++ Sbjct: 327 PESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEE 386 Query: 335 EKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMIS 378 EK KAA + S S+D K + + SRV S D D +S Sbjct: 387 EKVAKRKAA----VLSDSEDEEKASAKKSRVVSDADDSDSDAVS 426 >gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1 [Homo sapiens] Length = 651 Score = 73.6 bits (179), Expect = 3e-12 Identities = 71/331 (21%), Positives = 138/331 (41%), Gaps = 34/331 (10%) Query: 590 KSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTE 649 K ++ + K + K K +ES AES +++ +TK + KL+ + Sbjct: 304 KDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKK------D 357 Query: 650 ELKQNESRTTECKQNESTIVEPKQNENR-LSDTKPNDNKQNNGRSETTKSRPETPKQKGE 708 + K++ + E ES + +N++R L ND+K+ + + T + E+ + E Sbjct: 358 DKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKE 417 Query: 709 SRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDS 768 S+ + K K D + K + T +S P+ +K G+ + K + D+++D Sbjct: 418 SQKDEKKDKKDSKTDNKKSVKNDEEST---DADSEPKGDSKK--GKKDEKKGKKDSKKDD 472 Query: 769 GKPSTEKKPEVSKHKQD--TKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQK--- 823 K +K E ++ + D K D K ++ + D R +ES + D K Sbjct: 473 KKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGF 532 Query: 824 --------SDDRGESERHR-GDQSRVRRPETLRSSSRNE-----HGIKSDSSKTDKLERK 869 SD E ++ G + ++ + ++S+ E G + S KT E+ Sbjct: 533 KTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKG 592 Query: 870 HRHESG---DSRERPSSGEQKSRPDSPRVKQ 897 + +G SRE+P + SP+V++ Sbjct: 593 EKASTGRVPPSREKPPLPACEPSLPSPKVRR 623 Score = 62.4 bits (150), Expect = 6e-09 Identities = 89/481 (18%), Positives = 194/481 (40%), Gaps = 38/481 (7%) Query: 492 SKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRV 551 SK++ + +K ++ + D P ++ ++ S+ + T S+ + VS + Q + Sbjct: 144 SKQIVE-EKTKRQNEADKTPLKSSHENEQSKK-SKSSSETNPESQNSKTVSKNCSQKDKK 201 Query: 552 DSQASITQDSDSI-------KKPEEIKQCNDAPVSVLQED--------IVGSLKSTPENH 596 DS+ S +++ + K + K ND + E+ +VG N Sbjct: 202 DSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINF 261 Query: 597 PETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEE-LKQNE 655 + S +K ++ ++K N + + +S ++K K + ++ +K+++ Sbjct: 262 DAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDD 321 Query: 656 SRTTECKQNESTIVEPKQNENRLSDTKPNDNK-QNNGRSETTKSRPE-TPKQKGESRPET 713 + K EST E +++ DTK + K + + + + TK PE T + G+++ Sbjct: 322 KKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDAR 381 Query: 714 PKQKS-DGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRR------ 766 ++ + +K D + T ES E+ + + + + + + DN++ Sbjct: 382 NDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDE 441 Query: 767 DSGKPSTEKKPEVSKHKQDTKSDSP-RLKSERAEALKQRPDGRSVSESLRRDHDNKQKSD 825 +S +E K + K K+D K K ++ + K+ + + L D K + Sbjct: 442 ESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKE 501 Query: 826 DRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGE 885 +G + D + R +T + + + K+ + K++ ES +S +P G Sbjct: 502 KKGSKK----DIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDT-ESEESLYKP--GA 554 Query: 886 QKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKS---KVDTNKAHPDNKAEFP 942 +K +S + K GF+ + K +G K+ +V ++ P A P Sbjct: 555 KKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKPPLPACEP 614 Query: 943 S 943 S Sbjct: 615 S 615 Score = 62.0 bits (149), Expect = 8e-09 Identities = 104/541 (19%), Positives = 203/541 (37%), Gaps = 85/541 (15%) Query: 590 KSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTE 649 + TP H T K L K+E K+S+ + ++ + S E+K + + Sbjct: 96 EQTPFRHLYTSKT----HLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEK 151 Query: 650 ELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGES 709 +QNE+ T K + E +Q++ S ++ N QN+ S+ + K Sbjct: 152 TKRQNEADKTPLKSSH----ENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSK 207 Query: 710 RPETPKQKSDGHPETP----KQKGDGRPETPKQK----------GESRPET--------- 746 + T + +P+ K D E + G+S E+ Sbjct: 208 KTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRN 267 Query: 747 ---PKQKNEGRPETPKHRHDNRRDSGKPST-------EKKPEVSKHKQDTKSDSPR--LK 794 KN T + D ++++ K S + K + K K++ K D + +K Sbjct: 268 YSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVK 327 Query: 795 SERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEH 854 + + D + + ++D +K D + +++++ PE+ + S + Sbjct: 328 KDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKY---------PESTDTESGDAK 378 Query: 855 GIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPT 914 ++DS K K+ + D+++ S + +S +S ++ + + K K Sbjct: 379 DARNDSRNLKKAS-KNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSV 437 Query: 915 SKDDKRTEG-NKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQET 973 D++ T+ ++ K D+ K D K G+ + K+ K K+ T+ Sbjct: 438 KNDEESTDADSEPKGDSKKGKKDEKK--------GKKDSKKD--DKKKDAKKNAESTEME 487 Query: 974 KKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKL-------IKDREDKSRS 1026 +E+K + K EK G +D+ K A+ D+ K IK + +S Sbjct: 488 SDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEE 547 Query: 1027 SL-KPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKY 1085 SL KP K + G+ S ++ L + + S K++T NEK + Sbjct: 548 SLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSS-------------KKTTFNEKGEK 594 Query: 1086 A 1086 A Sbjct: 595 A 595 Score = 60.8 bits (146), Expect = 2e-08 Identities = 133/606 (21%), Positives = 218/606 (35%), Gaps = 131/606 (21%) Query: 693 SETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNE 752 S+T + E K K E + TP +K K+KG P+ K + E K++NE Sbjct: 106 SKTHLKKAEYKKSKDE-KGGTPLKKDS------KKKGGSYATNPESK-QIVEEKTKRQNE 157 Query: 753 GRPETPKHRHDNRRDS-GKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVS 811 K H+N + K S+E PE K +K+ S + K + + K + Sbjct: 158 ADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTK 217 Query: 812 ESLRRDHDNKQKSDDR-----GESERH--------RGDQSRVRRPETLRSSSRNEHGIKS 858 + ++D + S+D E+ + + D + LR+ S+N K+ Sbjct: 218 NNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNS--KN 275 Query: 859 DSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDD 918 S K K +K +K+ S + DS ++ D K KDD Sbjct: 276 YSLKYTKYTKKDT--------------KKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDD 321 Query: 919 KRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEM 978 K+ + K T+ D+K E ++D T++ KK Sbjct: 322 KKKDVKKDTESTDAESGDSKDE---------------------RKD-----TKKDKKKLK 355 Query: 979 KGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKS 1038 K + K +K D G KD + SR+ K KN K Sbjct: 356 KDDKKKDTKKYPESTDTESGDA-----------------KDARNDSRNLKKASKNDDKKK 398 Query: 1039 NKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDN-DSD 1097 + I S E +E+ES + K +K+ T N+K + +DE++ D+D Sbjct: 399 DAKKITFSTDSE------SELESKESQKDE-KKDKKDSKTDNKK----SVKNDEESTDAD 447 Query: 1098 EAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDME 1157 + K+ KKD+ K + ++D + D +++ S E +SD+E Sbjct: 448 SEPKGDSKKGKKDEKKGKKDSKKDDKKK-DAKKNAESTE---------------MESDLE 491 Query: 1158 DYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMD 1217 +K KK K+KK + K + + ST F S + + Sbjct: 492 -----------LKKDKKHSKEKKGSKKDIKKDARKDTE-STDAEFDESSKTGFKTSTKIK 539 Query: 1218 FTAFGDDDEIPQELLL--GKHQLNELGSESAKIKAMGIMDKLSTDKTVKVLNILEKNIQD 1275 G D E + L K +++E SA K G+ K + K EK Sbjct: 540 ----GSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEK---- 591 Query: 1276 GSKLST 1281 G K ST Sbjct: 592 GEKAST 597 Score = 45.8 bits (107), Expect = 6e-04 Identities = 56/306 (18%), Positives = 127/306 (41%), Gaps = 29/306 (9%) Query: 467 DEVELDALAEIERIERESAI---ERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRP 523 D+ + D + E + ES ER+ K+ + K KK+ YP+ +G + Sbjct: 320 DDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKD 379 Query: 524 ASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQE 583 A ++ + S+ + + + + DS+S + +E ++ + Sbjct: 380 ARNDSRNLKKASKN--------DDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKT 431 Query: 584 DIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETK 643 D S+K+ E+ + K D + K + K+ + +SK ++ + K++E+ T+ Sbjct: 432 DNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKK---DSKKDDKKKDAKKNAES---TE 485 Query: 644 VETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETP 703 +E+ ELK+++ + E K ++ I + + + +D + +++ + ++ T +T Sbjct: 486 MESDL-ELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTE 544 Query: 704 KQKGESRPETPKQ--KSDGHPETPKQKG---------DGRPETPKQKGESRPETPKQKNE 752 ++ +P K+ +SDG K +G + T +KGE + Sbjct: 545 SEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSR 604 Query: 753 GRPETP 758 +P P Sbjct: 605 EKPPLP 610 Score = 35.8 bits (81), Expect = 0.59 Identities = 48/228 (21%), Positives = 83/228 (36%), Gaps = 39/228 (17%) Query: 2476 KRKERKSSPSKENESSDSEEEVS--RPRKSRKRVDSDSDSDSEDDINSVMKCLPENSAPL 2533 K ++K K S+DSE E+ +K K+ DS +D++ + + + +S P Sbjct: 392 KNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPK 451 Query: 2534 IEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQT 2593 + +G K +K +S K K +K + Sbjct: 452 ---GDSKKG-------------------KKDEKKGKKDSKKDDKKKDAKKNAESTEMESD 489 Query: 2594 LDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSL 2653 L+ L+ D +SK + K+ I K D E + E S+ K T + Sbjct: 490 LE-LKKDKKHSKEKKGSKKDIKKD----------ARKDTESTDAEFDESSKTGFKTSTKI 538 Query: 2654 LGGGSPKNNT----AAETEDDESDGEDRGGGTSGVRRRRSQRISQRIT 2697 G + + A+ + DESDG G+ +R R+S + T Sbjct: 539 KGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKT 586 >gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens] Length = 1163 Score = 73.2 bits (178), Expect = 3e-12 Identities = 128/630 (20%), Positives = 232/630 (36%), Gaps = 77/630 (12%) Query: 322 KQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVE 381 K+ +Q G+ ++ K + S KD KL+ S D D ++D + Sbjct: 350 KESQQSNFGTGEQKRYNPSKTSNGHQSKSMLKDDLKLS------SSEDSDGEQDCDKTMP 403 Query: 382 NSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNT 441 S N P + G + + ++ + ++ AN+ Q+ Sbjct: 404 RSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEP---SQSA 460 Query: 442 SVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIER-----ERFSKEVQ 496 S + P T+ Q +++ P ++ S+++ + + KE + Sbjct: 461 SPEPEPPPTNKWQLDNWLNKVNP-------------HKVSPASSVDSNIPSSQGYKKEGR 507 Query: 497 DKDKPLKKRKQDSYPQEAGGATGGNRPASQETGS-TGNGSRPALMVSIDLHQAGRVDSQA 555 ++ S P+E AT G + + GS +G G + + S Q V + Sbjct: 508 EQGTG-NSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQ 566 Query: 556 SITQDSDSIKKPEE-IKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMK 614 + + ++P +K ++ PV D+ S+ S+ H K P + K E K Sbjct: 567 PKKAEKAAAEEPRGGLKIESETPV-----DLASSMPSS--RHKAATKGSRKPNIKK-ESK 618 Query: 615 QSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQN 674 S AE K ++ T S K +ET T +ES + PK Sbjct: 619 SSPRPTAEKKKYKS----TSKSSQKSREIIETDTSSSDSDESESLPPSSQT-----PKYP 669 Query: 675 ENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQ-------------KSDGH 721 E+ + KP+ ++ + P K+ E + + G Sbjct: 670 ESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGK 729 Query: 722 P--ETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNR-RDSGKPSTEKKPE 778 P ET KG+ + K E++ + ++ + K+ DNR +S KP TE K Sbjct: 730 PYKETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNS 789 Query: 779 VSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQS 838 HK + +S + + + + L P G S+ + +H +++++ + S + + + Sbjct: 790 AG-HKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSN 848 Query: 839 RVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQG 898 + ET SS + S +SK K E K S + +E+ S P +P + Sbjct: 849 K----ETSGSSKNS-----SSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTL--- 896 Query: 899 DSNKSRSDKLGFKSPT-SKDDKRTEGNKSK 927 DS+K R KL F S D E K K Sbjct: 897 DSSKPRRTKLVFDDRNYSADHYLQEAKKLK 926 Score = 65.5 bits (158), Expect = 7e-10 Identities = 113/608 (18%), Positives = 216/608 (35%), Gaps = 65/608 (10%) Query: 590 KSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTE 649 K+ P P K+ E K+ P++ S K + K+ + + Sbjct: 339 KTEPSKFPFPTKESQQSNFGTGEQKRYN-------PSKTSNGHQSKSMLKDDLKLSSSED 391 Query: 650 ELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGES 709 + + T + + EP + + +D +D+ ++G ++ S E+ +S Sbjct: 392 SDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDS 451 Query: 710 RPETPKQKSDGHPETPK----------QKGDGRPETPKQKGESR-PETPKQKNEGRPETP 758 P Q + PE P K + +P +S P + K EGR + Sbjct: 452 EANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGT 511 Query: 759 KHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDH 818 + + + S K+ + +D+K+ +S R +Q+ +S S + RR Sbjct: 512 GNSYTDT------SGPKETSSATPGRDSKTIQKGSESGRG---RQKSPAQSDSTTQRRTV 562 Query: 819 DNKQ-KSDDRGESERHRGD-QSRVRRPETLRSSS-RNEHGIKSDSSKTDKLERKHRHESG 875 KQ K ++ +E RG + P L SS + H + S+ ++++ + Sbjct: 563 GKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSPR 622 Query: 876 DSRERPS-SGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAH 934 + E+ KS S + + D++ S SD+ P+S+ K E N++ V Sbjct: 623 PTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVK----- 677 Query: 935 PDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVED 994 P + E S+ R + + +E + + EP D+ I + D Sbjct: 678 PSSVEEEDSFF-----------------RQRMFSPMEEKELLSPLSEPDDRYPLIVKI-D 719 Query: 995 LNK----GAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKE 1050 LN KP + + K + + + + + NK + +K D + Sbjct: 720 LNLLTRIPGKPYKETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASES 779 Query: 1051 LPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKD 1110 P+ E +++ K+S EK + + + SRKR Sbjct: 780 KKPK--TEDKNSAGHKPSSNRESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQ 837 Query: 1111 DDKAWEYEERDRRSSGDHRRSGHSH-----EGRRSSGGGRYRNRSPSDSDMEDYSPPPSL 1165 ++ +SG + S + EG+ SS + ++PS S S P Sbjct: 838 SSSLKSSSNSNKETSGSSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLD 897 Query: 1166 SEVARKMK 1173 S R+ K Sbjct: 898 SSKPRRTK 905 Score = 48.5 bits (114), Expect = 9e-05 Identities = 124/662 (18%), Positives = 224/662 (33%), Gaps = 65/662 (9%) Query: 602 KKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTEC 661 + + E E++Q E S P + S E+KL +++++ + + + Sbjct: 10 RMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSKEDKLSSRIQSMLGNYDEMKDFIGD- 68 Query: 662 KQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGH 721 + + PK +D K N N + +S TP S ++ K+ S Sbjct: 69 RSIPKLVAIPKPTVPPSADEKSNPNFFEQRHGGSHQSSKWTPVGPAPSTSQSQKRSSGLQ 128 Query: 722 PETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEV-- 779 Q+ + R + N G K +H + + S+ KP+ Sbjct: 129 SGHSSQRTSAGSSSGTNSSGQRHDRESYNNSGSSSRKKGQHGSEHSKSRSSSPGKPQAVS 188 Query: 780 ---SKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGD 836 S H + +D + +R+++ + PD S S R + Q S Sbjct: 189 SLNSSHSRSHGNDHHSKEHQRSKSPRD-PDANWDSPS-RVPFSSGQHSTQSFPPSLMSKS 246 Query: 837 QSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKH----RHESGDSRERPSSGEQKSR--- 889 S +++P + + S KL +H H + + +PSS ++ Sbjct: 247 NSMLQKP------TAYVRPMDGQESMEPKLSSEHYSSQSHGNSMTELKPSSKAHLTKLKI 300 Query: 890 PDSPRVKQGDSNKSRSDKL------GFKSPTS--KDDKRTEGNKSKVDTNKAHPDN---- 937 P P + S D++ + P + +TE +K T ++ N Sbjct: 301 PSQPLDASASGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNFGTG 360 Query: 938 --KAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDL 995 K PS G K+ +D + Q+ K + P E Sbjct: 361 EQKRYNPSKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEP---SHHN 417 Query: 996 NKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKS----------NKGSIDQ 1045 ++GA D E +S SS N+PS+S NK +D Sbjct: 418 SEGADNSRDDSSSHSGSESSSGSDSESESSSS-DSEANEPSQSASPEPEPPPTNKWQLDN 476 Query: 1046 SVLKELPPEL--LAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESS 1103 + K P ++ + ++S +P + K R++ T N Y + S ++ S S Sbjct: 477 WLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGN---SYTDTSGPKETSSATPGRDS 533 Query: 1104 RKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSS--------GGGRYRNRSPSDSD 1155 + K + + + S RR+ + +++ GG + + +P D Sbjct: 534 KTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLA 593 Query: 1156 MEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLED 1215 S P S + A K +K KK P+ T E+ ST K S E I + Sbjct: 594 S---SMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSS 650 Query: 1216 MD 1217 D Sbjct: 651 SD 652 Score = 42.7 bits (99), Expect = 0.005 Identities = 71/396 (17%), Positives = 145/396 (36%), Gaps = 73/396 (18%) Query: 318 SPERKQKKQKKMKLGKDEKEQSEKAAM--------------YDIISS------------- 350 SP + ++ +GK + +++EKAA D+ SS Sbjct: 549 SPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGS 608 Query: 351 -------PSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKT 403 SK S + T + +S+ Q+ +++ S++D ++ QT K Sbjct: 609 RKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKY 668 Query: 404 PITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQG 463 P + + +P + + S Q F P + +L + + P + G Sbjct: 669 PESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPG 728 Query: 464 PIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRP 523 Y E E + E+ + +++ S++V +K K K + D+ E+ +P Sbjct: 729 KPYKETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASES------KKP 782 Query: 524 ASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQE 583 +++ S G+ +P+ + R S+ S ++ D + P PV Sbjct: 783 KTEDKNSAGH--KPS---------SNRESSKQSAAKEKDLLPSPA-------GPV----- 819 Query: 584 DIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETK 643 P P+T +S+S +S S + ++ + S + K E K Sbjct: 820 ---------PSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSKQKKTEGK 870 Query: 644 VETQTEELKQN-ESRTTECKQNESTIVEPKQNENRL 678 + ++E+K+ S ++ C + T+ K +L Sbjct: 871 TSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPRRTKL 906 Score = 33.9 bits (76), Expect = 2.2 Identities = 19/70 (27%), Positives = 34/70 (48%) Query: 2453 IDITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSD 2512 +D+ S+ S + K S + +KE KSSP E + +KSR+ +++D+ Sbjct: 590 VDLASSMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSREIIETDTS 649 Query: 2513 SDSEDDINSV 2522 S D+ S+ Sbjct: 650 SSDSDESESL 659 >gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] Length = 2454 Score = 72.8 bits (177), Expect = 4e-12 Identities = 163/877 (18%), Positives = 311/877 (35%), Gaps = 114/877 (12%) Query: 408 QDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYD 467 +D+N A +++++ T + V+ A++ + ++ IS+ Sbjct: 373 EDLNSEFRAMDAVNKEKNT-----KEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLS 427 Query: 468 EVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQE 527 ++D+ E + + E +R +K + K ++++ Y N + Sbjct: 428 RKQVDS----EHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEP-------ANTSEDLD 476 Query: 528 TGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVG 587 S + +L A V Q+S+ D E+ + + +++ +D G Sbjct: 477 MDIVSVPSSVPEDIFENLETAMEV--QSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRG 534 Query: 588 SLKS--------------TP---ENHP-------ETPKKKSDPELSKSEMKQSESRLAES 623 +KS TP N P E P+ K + K + L + Sbjct: 535 GIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQE 594 Query: 624 KPNENRLVETKSS----ENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLS 679 + LVE + S E+ L +T L++ ++ E + + +LS Sbjct: 595 NSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLS 654 Query: 680 DTKPNDNKQNNGRSETTKSRP-ETPKQKGESRPETPKQKSDGHP------ETPKQKGDGR 732 +K+N+ S +P + PK K + ET Q SD E + Sbjct: 655 VPVRKKDKRNSSDSAIDNPKPNKLPKSK---QSETVDQNSDSDEMLAILKEVSRMSHSSS 711 Query: 733 PETPKQKGESRPET-------PKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQD 785 +T + + +T + ++G+ + + D+ K + K +SK K+ Sbjct: 712 SDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQ 771 Query: 786 TKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPET 845 T+S+S SE + +K + + +R + K D E E+H + + Sbjct: 772 TQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDF--DSSEDEKHSKKGMDNQGHKN 829 Query: 846 LRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGE---QKSRPDSPRVKQGDSNK 902 L++S +D ERK E+ S E + + R P+ +Q ++ Sbjct: 830 LKTSQEGS---------SDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASAST 880 Query: 903 SRSDKLGFK--SPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK 960 DKL K S TS + ++ K K K K + G S + F Sbjct: 881 DGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQ------DGLSDIAEKF---- 930 Query: 961 IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR 1020 +K+D+ +++ KK KG + K D K + + S D +KL +R Sbjct: 931 LKKDQSDETSEDDKKQSKKGTEEKKKPS-----DFKKKVIKMEQQYESSSDGTEKL-PER 984 Query: 1021 EDKSR--SSLKPIKNKPS----KSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKR 1074 E+ +K IKN + KS K S K+ + + C+ + K Sbjct: 985 EEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKS 1044 Query: 1075 KRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHS 1134 K + K ++ + S +++ +D ++R +R RR+ S Sbjct: 1045 KNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSS 1104 Query: 1135 HEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMM 1194 + G S SD E+ S K KK+ K+KA K + Sbjct: 1105 KRNTKEIQSGS------SSSDAEESSED-------NKKKKQRTSSKKKAVIVKEKKRNSL 1151 Query: 1195 DSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQEL 1231 +ST ++ + ++ED D + G+ Q++ Sbjct: 1152 RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKI 1188 Score = 72.0 bits (175), Expect = 7e-12 Identities = 131/646 (20%), Positives = 246/646 (38%), Gaps = 111/646 (17%) Query: 617 ESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNE---STIVEPKQ 673 + + + S ++L + S LE + +T+E K +T CK+ + S I E Sbjct: 873 KQQASASTDGVDKLSGKEQSFTSLEVRKVAETKE-KSKHLKTKTCKKVQDGLSDIAEKFL 931 Query: 674 NENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETP-------- 725 +++ +T +D KQ+ +E K +P K+K + + SDG + P Sbjct: 932 KKDQSDETSEDDKKQSKKGTEE-KKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHF 990 Query: 726 ----KQKGDGRPETPKQKGESRPETPKQKNE---------GRPETPKHRHDNRRDSGKPS 772 KQ +G + K+ + R +T K+K+E G+ ++ D + +G Sbjct: 991 PKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1050 Query: 773 TEKK-----PEVSKHKQDTKSDSPRLKSERAEA------------------------LKQ 803 EKK + S+ +QD S S + + K+ Sbjct: 1051 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKE 1110 Query: 804 RPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKT 863 G S S++ DNK+K + S + + + ++ +LR+S++ + + SS + Sbjct: 1111 IQSGSSSSDAEESSEDNKKKK--QRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSS 1168 Query: 864 DKLERKHRHESGDSRERPSSGEQKSRPDSPRV----KQGDSNKSRSDKLGFKSPTSKDDK 919 D +E ++ G+ SS EQK +P + + G S + L P + DD Sbjct: 1169 D-IEDDDQNSIGEG----SSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDD- 1222 Query: 920 RTEGNKSKVDTNKAHPDNK-------AEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQE 972 D + P+N+ E + L G+ + P+ + + G +E Sbjct: 1223 ---------DDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDD--EPEEGKKRTGKQNEE 1271 Query: 973 TKKMEMKGEPKDKVEKIGLVEDLNKGAKP----VVVLQKLSLDD----VQKLIKDREDKS 1024 E E K++V D + KP ++ KL++ D +K K +E K Sbjct: 1272 NPGDE---EAKNQVNSES-DSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKE 1327 Query: 1025 RSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPK 1084 K S +S + E E E ++ ++ + +RS +K K Sbjct: 1328 VKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRS-YKQKKK 1386 Query: 1085 YAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGG 1144 I ED+ S+ S + +K++++ E EE + ++ +S G G Sbjct: 1387 RRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEED--------ENDDSKSPGKG 1438 Query: 1145 RYRNRSPSDSDMEDYSPPPSLSEVARKMKK-----KEKQKKRKAYE 1185 R + R D +L E + K+ +E++K R+ E Sbjct: 1439 RKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIE 1484 Score = 68.6 bits (166), Expect = 8e-11 Identities = 199/1013 (19%), Positives = 378/1013 (37%), Gaps = 147/1013 (14%) Query: 322 KQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVE 381 K+K K+ K+ D K +++ + KD +K +LSR + +++ + + Sbjct: 387 KEKNTKEHKV-IDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQ 445 Query: 382 NSNVS------ENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVP 435 +N S ++D QY + + ++ P + + + + +TA + V Sbjct: 446 RTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVD 505 Query: 436 VLQQNTSVAAKQPQTSVVQ-NQQQISQQGPIYDEVELDALAEIERIERESAIERERFSK- 493 +S ++ ++S V+ N +G I + + + + +E + K Sbjct: 506 HQGDGSSGTEQEVESSSVKLNISSKDNRGGI-------------KSKTTAKVTKELYVKL 552 Query: 494 -EVQDKDKPLKKRKQDSYPQEAGGATG-GNRPASQETGSTGNGSR---------PALMVS 542 V + P+K PQ+ G G P ++ G S L+ Sbjct: 553 TPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEE 612 Query: 543 IDLHQAGRVDSQA--------SITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPE 594 DL ++ RV + +T +SD + E +K+ V V ++D S S + Sbjct: 613 SDLRRSPRVKTTPLRRPTETNPVTSNSDE-ECNETVKEKQKLSVPVRKKDKRNSSDSAID 671 Query: 595 N----------HPETPKKKSDP--------ELSK-SEMKQSESRLAESKPNENRLVETKS 635 N ET + SD E+S+ S S++ + E N L + K+ Sbjct: 672 NPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKT 731 Query: 636 SENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNN----- 690 K + + ++ T + K +S+I+ K+ + + + + + Sbjct: 732 QAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMS 791 Query: 691 --GRSETTKSRPETPKQKGESRPETPKQK---SDGHPE-TPKQKGDGRPETPKQKGE--S 742 G + TTK R K S E +K + GH Q+G KQ+ E S Sbjct: 792 KIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFS 851 Query: 743 RPETPKQKN----EGRPETPKHRHDNR------RDSGKPSTEKKPEVSKHKQDTKSDSPR 792 E K+ E R PK + + + SGK + EV K +TK S Sbjct: 852 SAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRK-VAETKEKSKH 910 Query: 793 LKSERAEALKQRPDGRS--VSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSS 850 LK+ + K+ DG S + L++D ++ DD+ +S+ +G + + + + + Sbjct: 911 LKT---KTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSK--KGTEEKKKPSDFKKKVI 965 Query: 851 RNEHGIKSDSSKTDKLERKHR-----HESGDSRERPSSGEQKSRPDSPRVK--------- 896 + E +S S T+KL + + + GE+KS+ + Sbjct: 966 KMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDY 1025 Query: 897 ------QGDSNKSRSDKLGFKSPTSKDDKRTE--GNKSKVDTNKAHPDNKAEFPSYLLGG 948 +GDS S DK ++ KR + G S+ + + D E S G Sbjct: 1026 AEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD--TEKYSMKEDG 1083 Query: 949 RSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNK------GAKPV 1002 + + K +++ ++ + + TK+++ D E ED K K Sbjct: 1084 CNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEES---SEDNKKKKQRTSSKKKA 1140 Query: 1003 VVLQKLSLDDVQKLIKDRE-DKSRSSLKPIKNKPSKS-NKGSIDQSVLKELPPELLAEIE 1060 V++++ + ++ K ++ D + SS I++ S +GS D+ +K + L+ + Sbjct: 1141 VIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLV--LS 1198 Query: 1061 STMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEER 1120 S C+ S K ++ D+D+D ++ K+ ++ KA + Sbjct: 1199 SHTGFCQ--------SSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDE 1250 Query: 1121 DRRSSGD----HRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKE 1176 D S + +R+G +E + + S SDSD E+ P + R K Sbjct: 1251 DGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLR--HKLT 1308 Query: 1177 KQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQ 1229 E K P+E + R S E + ED DF G +E+ + Sbjct: 1309 VSDGESGEEKKTKPKEHKEVKGRNRRKVSSE----DSEDSDFQESGVSEEVSE 1357 Score = 33.1 bits (74), Expect = 3.8 Identities = 50/219 (22%), Positives = 84/219 (38%), Gaps = 40/219 (18%) Query: 2460 SGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVD--SDSDSDSED 2517 SGS+ + + S K+K+R SS K + + R RK+ D S S SD ED Sbjct: 1113 SGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIED 1172 Query: 2518 DINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYD 2577 D + + E S+ + V++ L+L H GF S D Sbjct: 1173 DDQN---SIGEGSSDEQKIKPVTEN----LVLSSH----TGFCQSS------------GD 1209 Query: 2578 KAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEG 2637 +A+++ V + + +A + EE+K ++ E D+E EEG Sbjct: 1210 EALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD--------EDGSSDDEPEEG 1261 Query: 2638 EV-SASTNARNKAITSLLGGGSPKNNTAAETEDDESDGE 2675 + + N N G KN +E++ D + + Sbjct: 1262 KKRTGKQNEENP------GDEEAKNQVNSESDSDSEESK 1294 >gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] Length = 2492 Score = 72.8 bits (177), Expect = 4e-12 Identities = 163/877 (18%), Positives = 311/877 (35%), Gaps = 114/877 (12%) Query: 408 QDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYD 467 +D+N A +++++ T + V+ A++ + ++ IS+ Sbjct: 411 EDLNSEFRAMDAVNKEKNT-----KEHKVIDAKFETKARKGEKPCALEKKDISKSEAKLS 465 Query: 468 EVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQE 527 ++D+ E + + E +R +K + K ++++ Y N + Sbjct: 466 RKQVDS----EHMHQNVPTEEQRTNKSTGGEHKKSDRKEEPQYEP-------ANTSEDLD 514 Query: 528 TGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVG 587 S + +L A V Q+S+ D E+ + + +++ +D G Sbjct: 515 MDIVSVPSSVPEDIFENLETAMEV--QSSVDHQGDGSSGTEQEVESSSVKLNISSKDNRG 572 Query: 588 SLKS--------------TP---ENHP-------ETPKKKSDPELSKSEMKQSESRLAES 623 +KS TP N P E P+ K + K + L + Sbjct: 573 GIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQE 632 Query: 624 KPNENRLVETKSS----ENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLS 679 + LVE + S E+ L +T L++ ++ E + + +LS Sbjct: 633 NSDNEHLVENEVSLLLEESDLRRSPRVKTTPLRRPTETNPVTSNSDEECNETVKEKQKLS 692 Query: 680 DTKPNDNKQNNGRSETTKSRP-ETPKQKGESRPETPKQKSDGHP------ETPKQKGDGR 732 +K+N+ S +P + PK K + ET Q SD E + Sbjct: 693 VPVRKKDKRNSSDSAIDNPKPNKLPKSK---QSETVDQNSDSDEMLAILKEVSRMSHSSS 749 Query: 733 PETPKQKGESRPET-------PKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQD 785 +T + + +T + ++G+ + + D+ K + K +SK K+ Sbjct: 750 SDTDINEIHTNHKTLYDLKTQAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQ 809 Query: 786 TKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPET 845 T+S+S SE + +K + + +R + K D E E+H + + Sbjct: 810 TQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKDF--DSSEDEKHSKKGMDNQGHKN 867 Query: 846 LRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGE---QKSRPDSPRVKQGDSNK 902 L++S +D ERK E+ S E + + R P+ +Q ++ Sbjct: 868 LKTSQEGS---------SDDAERKQERETFSSAEGTVDKDTTIMELRDRLPKKQQASAST 918 Query: 903 SRSDKLGFK--SPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPK 960 DKL K S TS + ++ K K K K + G S + F Sbjct: 919 DGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKKVQ------DGLSDIAEKF---- 968 Query: 961 IKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR 1020 +K+D+ +++ KK KG + K D K + + S D +KL +R Sbjct: 969 LKKDQSDETSEDDKKQSKKGTEEKKKPS-----DFKKKVIKMEQQYESSSDGTEKL-PER 1022 Query: 1021 EDKSR--SSLKPIKNKPS----KSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKR 1074 E+ +K IKN + KS K S K+ + + C+ + K Sbjct: 1023 EEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKS 1082 Query: 1075 KRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHS 1134 K + K ++ + S +++ +D ++R +R RR+ S Sbjct: 1083 KNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSS 1142 Query: 1135 HEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMM 1194 + G S SD E+ S K KK+ K+KA K + Sbjct: 1143 KRNTKEIQSGS------SSSDAEESSED-------NKKKKQRTSSKKKAVIVKEKKRNSL 1189 Query: 1195 DSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQEL 1231 +ST ++ + ++ED D + G+ Q++ Sbjct: 1190 RTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKI 1226 Score = 72.0 bits (175), Expect = 7e-12 Identities = 131/646 (20%), Positives = 246/646 (38%), Gaps = 111/646 (17%) Query: 617 ESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNE---STIVEPKQ 673 + + + S ++L + S LE + +T+E K +T CK+ + S I E Sbjct: 911 KQQASASTDGVDKLSGKEQSFTSLEVRKVAETKE-KSKHLKTKTCKKVQDGLSDIAEKFL 969 Query: 674 NENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETP-------- 725 +++ +T +D KQ+ +E K +P K+K + + SDG + P Sbjct: 970 KKDQSDETSEDDKKQSKKGTEE-KKKPSDFKKKVIKMEQQYESSSDGTEKLPEREEICHF 1028 Query: 726 ----KQKGDGRPETPKQKGESRPETPKQKNE---------GRPETPKHRHDNRRDSGKPS 772 KQ +G + K+ + R +T K+K+E G+ ++ D + +G Sbjct: 1029 PKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKNGAYG 1088 Query: 773 TEKK-----PEVSKHKQDTKSDSPRLKSERAEA------------------------LKQ 803 EKK + S+ +QD S S + + K+ Sbjct: 1089 REKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKE 1148 Query: 804 RPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKT 863 G S S++ DNK+K + S + + + ++ +LR+S++ + + SS + Sbjct: 1149 IQSGSSSSDAEESSEDNKKKK--QRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSS 1206 Query: 864 DKLERKHRHESGDSRERPSSGEQKSRPDSPRV----KQGDSNKSRSDKLGFKSPTSKDDK 919 D +E ++ G+ SS EQK +P + + G S + L P + DD Sbjct: 1207 D-IEDDDQNSIGEG----SSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDD- 1260 Query: 920 RTEGNKSKVDTNKAHPDNK-------AEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQE 972 D + P+N+ E + L G+ + P+ + + G +E Sbjct: 1261 ---------DDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDD--EPEEGKKRTGKQNEE 1309 Query: 973 TKKMEMKGEPKDKVEKIGLVEDLNKGAKP----VVVLQKLSLDD----VQKLIKDREDKS 1024 E E K++V D + KP ++ KL++ D +K K +E K Sbjct: 1310 NPGDE---EAKNQVNSES-DSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKE 1365 Query: 1025 RSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPK 1084 K S +S + E E E ++ ++ + +RS +K K Sbjct: 1366 VKGRNRRKVSSEDSEDSDFQESGVSEEVSESEDEQRPRTRSAKKAELEENQRS-YKQKKK 1424 Query: 1085 YAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGG 1144 I ED+ S+ S + +K++++ E EE + ++ +S G G Sbjct: 1425 RRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEED--------ENDDSKSPGKG 1476 Query: 1145 RYRNRSPSDSDMEDYSPPPSLSEVARKMKK-----KEKQKKRKAYE 1185 R + R D +L E + K+ +E++K R+ E Sbjct: 1477 RKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIE 1522 Score = 68.6 bits (166), Expect = 8e-11 Identities = 199/1013 (19%), Positives = 378/1013 (37%), Gaps = 147/1013 (14%) Query: 322 KQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVE 381 K+K K+ K+ D K +++ + KD +K +LSR + +++ + + Sbjct: 425 KEKNTKEHKV-IDAKFETKARKGEKPCALEKKDISKSEAKLSRKQVDSEHMHQNVPTEEQ 483 Query: 382 NSNVS------ENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVP 435 +N S ++D QY + + ++ P + + + + +TA + V Sbjct: 484 RTNKSTGGEHKKSDRKEEPQYEPANTSEDLDMDIVSVPSSVPEDIFENLETAMEVQSSVD 543 Query: 436 VLQQNTSVAAKQPQTSVVQ-NQQQISQQGPIYDEVELDALAEIERIERESAIERERFSK- 493 +S ++ ++S V+ N +G I + + + + +E + K Sbjct: 544 HQGDGSSGTEQEVESSSVKLNISSKDNRGGI-------------KSKTTAKVTKELYVKL 590 Query: 494 -EVQDKDKPLKKRKQDSYPQEAGGATG-GNRPASQETGSTGNGSR---------PALMVS 542 V + P+K PQ+ G G P ++ G S L+ Sbjct: 591 TPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGLGQENSDNEHLVENEVSLLLEE 650 Query: 543 IDLHQAGRVDSQA--------SITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPE 594 DL ++ RV + +T +SD + E +K+ V V ++D S S + Sbjct: 651 SDLRRSPRVKTTPLRRPTETNPVTSNSDE-ECNETVKEKQKLSVPVRKKDKRNSSDSAID 709 Query: 595 N----------HPETPKKKSDP--------ELSK-SEMKQSESRLAESKPNENRLVETKS 635 N ET + SD E+S+ S S++ + E N L + K+ Sbjct: 710 NPKPNKLPKSKQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKT 769 Query: 636 SENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNN----- 690 K + + ++ T + K +S+I+ K+ + + + + + Sbjct: 770 QAGKDDKGKRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMS 829 Query: 691 --GRSETTKSRPETPKQKGESRPETPKQK---SDGHPE-TPKQKGDGRPETPKQKGE--S 742 G + TTK R K S E +K + GH Q+G KQ+ E S Sbjct: 830 KIGAARTTKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFS 889 Query: 743 RPETPKQKN----EGRPETPKHRHDNR------RDSGKPSTEKKPEVSKHKQDTKSDSPR 792 E K+ E R PK + + + SGK + EV K +TK S Sbjct: 890 SAEGTVDKDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRK-VAETKEKSKH 948 Query: 793 LKSERAEALKQRPDGRS--VSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSS 850 LK+ + K+ DG S + L++D ++ DD+ +S+ +G + + + + + Sbjct: 949 LKT---KTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSK--KGTEEKKKPSDFKKKVI 1003 Query: 851 RNEHGIKSDSSKTDKLERKHR-----HESGDSRERPSSGEQKSRPDSPRVK--------- 896 + E +S S T+KL + + + GE+KS+ + Sbjct: 1004 KMEQQYESSSDGTEKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDY 1063 Query: 897 ------QGDSNKSRSDKLGFKSPTSKDDKRTE--GNKSKVDTNKAHPDNKAEFPSYLLGG 948 +GDS S DK ++ KR + G S+ + + D E S G Sbjct: 1064 AEKSTGKGDSCDSSEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSD--TEKYSMKEDG 1121 Query: 949 RSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNK------GAKPV 1002 + + K +++ ++ + + TK+++ D E ED K K Sbjct: 1122 CNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAEES---SEDNKKKKQRTSSKKKA 1178 Query: 1003 VVLQKLSLDDVQKLIKDRE-DKSRSSLKPIKNKPSKS-NKGSIDQSVLKELPPELLAEIE 1060 V++++ + ++ K ++ D + SS I++ S +GS D+ +K + L+ + Sbjct: 1179 VIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLV--LS 1236 Query: 1061 STMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEER 1120 S C+ S K ++ D+D+D ++ K+ ++ KA + Sbjct: 1237 SHTGFCQ--------SSGDEALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSDE 1288 Query: 1121 DRRSSGD----HRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKE 1176 D S + +R+G +E + + S SDSD E+ P + R K Sbjct: 1289 DGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLR--HKLT 1346 Query: 1177 KQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLEDMDFTAFGDDDEIPQ 1229 E K P+E + R S E + ED DF G +E+ + Sbjct: 1347 VSDGESGEEKKTKPKEHKEVKGRNRRKVSSE----DSEDSDFQESGVSEEVSE 1395 Score = 33.1 bits (74), Expect = 3.8 Identities = 50/219 (22%), Positives = 84/219 (38%), Gaps = 40/219 (18%) Query: 2460 SGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVD--SDSDSDSED 2517 SGS+ + + S K+K+R SS K + + R RK+ D S S SD ED Sbjct: 1151 SGSSSSDAEESSEDNKKKKQRTSSKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIED 1210 Query: 2518 DINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYD 2577 D + + E S+ + V++ L+L H GF S D Sbjct: 1211 DDQN---SIGEGSSDEQKIKPVTEN----LVLSSH----TGFCQSS------------GD 1247 Query: 2578 KAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEG 2637 +A+++ V + + +A + EE+K ++ E D+E EEG Sbjct: 1248 EALSKSVPVTVDDDDDDNDPENRIAKKMLLEEIKANLSSD--------EDGSSDDEPEEG 1299 Query: 2638 EV-SASTNARNKAITSLLGGGSPKNNTAAETEDDESDGE 2675 + + N N G KN +E++ D + + Sbjct: 1300 KKRTGKQNEENP------GDEEAKNQVNSESDSDSEESK 1332 >gi|116089325 splicing factor, arginine/serine-rich 12 isoform a [Homo sapiens] Length = 624 Score = 72.8 bits (177), Expect = 4e-12 Identities = 82/382 (21%), Positives = 148/382 (38%), Gaps = 62/382 (16%) Query: 589 LKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQT 648 LK N+ + P+ + E+++ R+ E++ + +E +S ++ Sbjct: 251 LKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSN--------- 301 Query: 649 EELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRS-ETTKSRPETPKQKG 707 E K SR+ ++ S+ + + S +K N RS + + R ++P +K Sbjct: 302 -ERKGGRSRSHTRSKSRSS--SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 358 Query: 708 ESRPETPKQKSDGHP--------ETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPK 759 E K +S H E K+K + + +++ E E K+K G+ + Sbjct: 359 SKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 418 Query: 760 HRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHD 819 + R+ K ++ +H++D + K + + K+R RS ++ D Sbjct: 419 KEREKDREKDKEKDREREREKEHEKDRDKE----KEKEQDKEKEREKDRS------KEID 468 Query: 820 NKQKSDDRG-------ESERHRGDQSRVRRPETLRSSSRNEHGIKS------------DS 860 K+K D + + R SR RR RSSSR+ K+ Sbjct: 469 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 528 Query: 861 SKTDKLERKHRHESGDSRERPSS-----------GEQKSRPDSPRVKQGDSNKSRSDKLG 909 +K DK K R + RER S G++K +S +K+ + NK + Sbjct: 529 NKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVS 588 Query: 910 FKSPTSKDDKRTEGNKSKVDTN 931 K KD RTE NK + + N Sbjct: 589 -KEVDDKDAPRTEENKIQHNGN 609 Score = 48.5 bits (114), Expect = 9e-05 Identities = 75/383 (19%), Positives = 144/383 (37%), Gaps = 86/383 (22%) Query: 794 KSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNE 853 KS + + R RS S S + H +++S + S H ++SR R+ + RS S ++ Sbjct: 299 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSH--NRSRSRQKDRRRSKSPHK 356 Query: 854 HGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSP 913 KS + + R + D+RE+ E RVK+ D K R + Sbjct: 357 KRSKSRERRKSRSRSHSRDKRKDTREKIKEKE--------RVKEKDREKERERE------ 402 Query: 914 TSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQET 973 + +K E K+K D +K ++ ++DK+ + +E Sbjct: 403 -KEREKEKERGKNK-DRDKEREKDR-----------------------EKDKEKDRERER 437 Query: 974 KKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKN 1033 +K K K+K ++ ++ K D K I ++ K + S P Sbjct: 438 EKEHEKDRDKEKEKEQDKEKEREK--------------DRSKEIDEKRKKDKKSRTP--- 480 Query: 1034 KPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDED 1093 P N +S +E + +R RS+ + P+ ++ + Sbjct: 481 -PRSYNASRRSRSSSRE-------------------RRRRRSRSS-SRSPRTSKTIKRKS 519 Query: 1094 NDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSD 1153 + S ++K K++ ++ E R+R S R+S + +G+ + S S Sbjct: 520 SRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKE-----KLEKNSTSL 574 Query: 1154 SDMEDYSPPPSLSEVARKMKKKE 1176 + E P S V++++ K+ Sbjct: 575 KEKEHNKEPD--SSVSKEVDDKD 595 Score = 43.5 bits (101), Expect = 0.003 Identities = 41/191 (21%), Positives = 78/191 (40%), Gaps = 27/191 (14%) Query: 1020 REDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTV 1079 ++D+ RS K S+ + S +S ++ + +I+ + E+ + +R+R Sbjct: 345 QKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKE 404 Query: 1080 NEKPKYAEISSDEDNDSDEAFESSR---------KRHKKDDDKAWEYEERDRRSSGDHRR 1130 EK K + D D + ++ E + K H+KD DK E +E+D+ + R Sbjct: 405 REKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKE-KEQDKEKEREKDR 463 Query: 1131 SGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTP 1190 S E R+ D + +PP S + R ++++R++ +P Sbjct: 464 SKEIDEKRK--------------KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSP 509 Query: 1191 EEMMDSSTFKR 1201 S T KR Sbjct: 510 R---TSKTIKR 517 Score = 38.5 bits (88), Expect = 0.090 Identities = 66/345 (19%), Positives = 121/345 (35%), Gaps = 67/345 (19%) Query: 878 RERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDN 937 RE S P+S + + +SRS +SK R + ++SK +++ N Sbjct: 283 REAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK---HRSRSHN 339 Query: 938 KAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNK 997 ++ R + P KR K + + + + KD EKI E + + Sbjct: 340 RSR-------SRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 392 Query: 998 GAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLA 1057 KDRE + + K K NK Sbjct: 393 --------------------KDREKEREREKEREKEKERGKNKDR--------------- 417 Query: 1058 EIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSR-KRHKKDDDKAWE 1116 ++ + R++ ++ + E ++D D ++ E + K +KD K + Sbjct: 418 ---------DKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEID 468 Query: 1117 YEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARK----- 1171 + + + S RS ++ RSS R R RS S S P + + RK Sbjct: 469 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS-----RSPRTSKTIKRKSSRSP 523 Query: 1172 --MKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLE 1214 + +K KKR+ ++ + ST R +++ + + LE Sbjct: 524 SPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLE 568 >gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [Homo sapiens] Length = 508 Score = 72.8 bits (177), Expect = 4e-12 Identities = 82/382 (21%), Positives = 148/382 (38%), Gaps = 62/382 (16%) Query: 589 LKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQT 648 LK N+ + P+ + E+++ R+ E++ + +E +S ++ Sbjct: 135 LKINHSNNAIVKPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSN--------- 185 Query: 649 EELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRS-ETTKSRPETPKQKG 707 E K SR+ ++ S+ + + S +K N RS + + R ++P +K Sbjct: 186 -ERKGGRSRSHTRSKSRSS--SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 242 Query: 708 ESRPETPKQKSDGHP--------ETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPK 759 E K +S H E K+K + + +++ E E K+K G+ + Sbjct: 243 SKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRD 302 Query: 760 HRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHD 819 + R+ K ++ +H++D + K + + K+R RS ++ D Sbjct: 303 KEREKDREKDKEKDREREREKEHEKDRDKE----KEKEQDKEKEREKDRS------KEID 352 Query: 820 NKQKSDDRG-------ESERHRGDQSRVRRPETLRSSSRNEHGIKS------------DS 860 K+K D + + R SR RR RSSSR+ K+ Sbjct: 353 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 412 Query: 861 SKTDKLERKHRHESGDSRERPSS-----------GEQKSRPDSPRVKQGDSNKSRSDKLG 909 +K DK K R + RER S G++K +S +K+ + NK + Sbjct: 413 NKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVS 472 Query: 910 FKSPTSKDDKRTEGNKSKVDTN 931 K KD RTE NK + + N Sbjct: 473 -KEVDDKDAPRTEENKIQHNGN 493 Score = 48.5 bits (114), Expect = 9e-05 Identities = 75/383 (19%), Positives = 144/383 (37%), Gaps = 86/383 (22%) Query: 794 KSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNE 853 KS + + R RS S S + H +++S + S H ++SR R+ + RS S ++ Sbjct: 183 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSH--NRSRSRQKDRRRSKSPHK 240 Query: 854 HGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSP 913 KS + + R + D+RE+ E RVK+ D K R + Sbjct: 241 KRSKSRERRKSRSRSHSRDKRKDTREKIKEKE--------RVKEKDREKERERE------ 286 Query: 914 TSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQET 973 + +K E K+K D +K ++ ++DK+ + +E Sbjct: 287 -KEREKEKERGKNK-DRDKEREKDR-----------------------EKDKEKDRERER 321 Query: 974 KKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKN 1033 +K K K+K ++ ++ K D K I ++ K + S P Sbjct: 322 EKEHEKDRDKEKEKEQDKEKEREK--------------DRSKEIDEKRKKDKKSRTP--- 364 Query: 1034 KPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDED 1093 P N +S +E + +R RS+ + P+ ++ + Sbjct: 365 -PRSYNASRRSRSSSRE-------------------RRRRRSRSS-SRSPRTSKTIKRKS 403 Query: 1094 NDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSD 1153 + S ++K K++ ++ E R+R S R+S + +G+ + S S Sbjct: 404 SRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKE-----KLEKNSTSL 458 Query: 1154 SDMEDYSPPPSLSEVARKMKKKE 1176 + E P S V++++ K+ Sbjct: 459 KEKEHNKEPD--SSVSKEVDDKD 479 Score = 43.5 bits (101), Expect = 0.003 Identities = 41/191 (21%), Positives = 78/191 (40%), Gaps = 27/191 (14%) Query: 1020 REDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTV 1079 ++D+ RS K S+ + S +S ++ + +I+ + E+ + +R+R Sbjct: 229 QKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKE 288 Query: 1080 NEKPKYAEISSDEDNDSDEAFESSR---------KRHKKDDDKAWEYEERDRRSSGDHRR 1130 EK K + D D + ++ E + K H+KD DK E +E+D+ + R Sbjct: 289 REKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKE-KEQDKEKEREKDR 347 Query: 1131 SGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTP 1190 S E R+ D + +PP S + R ++++R++ +P Sbjct: 348 SKEIDEKRK--------------KDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSP 393 Query: 1191 EEMMDSSTFKR 1201 S T KR Sbjct: 394 R---TSKTIKR 401 Score = 38.5 bits (88), Expect = 0.090 Identities = 66/345 (19%), Positives = 121/345 (35%), Gaps = 67/345 (19%) Query: 878 RERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDN 937 RE S P+S + + +SRS +SK R + ++SK +++ N Sbjct: 167 REAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSK---HRSRSHN 223 Query: 938 KAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNK 997 ++ R + P KR K + + + + KD EKI E + + Sbjct: 224 RSR-------SRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKE 276 Query: 998 GAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLA 1057 KDRE + + K K NK Sbjct: 277 --------------------KDREKEREREKEREKEKERGKNKDR--------------- 301 Query: 1058 EIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSR-KRHKKDDDKAWE 1116 ++ + R++ ++ + E ++D D ++ E + K +KD K + Sbjct: 302 ---------DKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEID 352 Query: 1117 YEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARK----- 1171 + + + S RS ++ RSS R R RS S S P + + RK Sbjct: 353 EKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSS-----RSPRTSKTIKRKSSRSP 407 Query: 1172 --MKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNLE 1214 + +K KKR+ ++ + ST R +++ + + LE Sbjct: 408 SPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLE 452 >gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo sapiens] Length = 600 Score = 72.4 bits (176), Expect = 6e-12 Identities = 56/350 (16%), Positives = 141/350 (40%), Gaps = 13/350 (3%) Query: 595 NHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQN 654 N + +++++ E + +Q++ + + + + ++ + + + E ++ ++ Sbjct: 122 NRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERER 181 Query: 655 ESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETP 714 E E ++ E + + E+R S+ ++ +ET + R ++ + + E Sbjct: 182 EKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERE 241 Query: 715 KQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTE 774 ++K +++ + E +++ R +QK R K + RD TE Sbjct: 242 REKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDR---ETE 298 Query: 775 KKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHR 834 +K E + ++ + + + + ER E ++R R ++ + K+K + ER+R Sbjct: 299 RKRERQRERERERERNRKRERER-ERERERERQRETERDREKERERKRKRQTEMDRERNR 357 Query: 835 ---------GDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGE 885 ++ R R E R S+R + D + + ER+ + E +R + + Sbjct: 358 QTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQ 417 Query: 886 QKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHP 935 ++ D + + + R + G + + R G + K T +P Sbjct: 418 REREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNP 467 Score = 67.8 bits (164), Expect = 1e-10 Identities = 76/413 (18%), Positives = 158/413 (38%), Gaps = 27/413 (6%) Query: 596 HPETPKKKSDPELSKSEMKQSESRLAESKPNENR-LVETKSSENKLETKVETQTEELKQN 654 H + + K ++ E R E + + R K K + E Q + K+ Sbjct: 46 HKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKER 105 Query: 655 ESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETP 714 E +T + + +Q E + + + GR T + E +Q+ + Sbjct: 106 ERQTDRERDRQREKERNRQKERE----RETEREGERGRDRQTDGQRERERQRDAEKERER 161 Query: 715 KQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTE 774 + + +T + + R E K + E R +++ E + E RH R + E Sbjct: 162 QTDRERQRQTERNRQKER-EREKNRQERRERERQREKENKTE---DRHSERGRERERERE 217 Query: 775 KKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSD-----DRGE 829 + E + +Q + + K+ER E KQ R+ RD + +++ D DR + Sbjct: 218 TETETERKRQTDRERDRQRKTER-EREKQAERERASERETERDKERERERDRDRDRDRRQ 276 Query: 830 SERHR-GDQSRVRRPETLRSSSR---NEHGIKSDSSKTDKLERKHRHESGDSRERPSSGE 885 ER R D+ R RR E R + R + + + + K ER+ E R+R + + Sbjct: 277 KERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERD 336 Query: 886 QKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYL 945 ++ + R +Q + ++ R+ + G + + +R + + + + + + Sbjct: 337 REKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERD----- 391 Query: 946 LGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKG 998 R + + ++D+DG E ++ K ++ + G + KG Sbjct: 392 ---RDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKG 441 Score = 65.9 bits (159), Expect = 5e-10 Identities = 68/399 (17%), Positives = 157/399 (39%), Gaps = 23/399 (5%) Query: 601 KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660 ++++D E + K+ + + E + + + + E Q + K+ E +T Sbjct: 106 ERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDR 165 Query: 661 CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETP-----K 715 +Q ++ K+ E + + + ++ + T+ R ++ E ET K Sbjct: 166 ERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERK 225 Query: 716 QKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEK 775 +++D + ++ R + +++ S ET + K R D R+ + T++ Sbjct: 226 RQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDR 285 Query: 776 KPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHR- 834 K + + ++D +++ R + E ++R R R+ + +++++ E ER R Sbjct: 286 KRQ-RRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERK 344 Query: 835 ----GDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRP 890 + R R +T R R + + D+ + R E R+R E++ + Sbjct: 345 RKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQT 404 Query: 891 DSPRVKQGDSNKSRSDKLGFKSPTSKD-DKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGR 949 + R Q ++ K R + +S ++ + E K + + D +A G + Sbjct: 405 EKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQA-------GRQ 457 Query: 950 SGALKNFVIPKIKRDKDGNVTQE----TKKMEMKGEPKD 984 +V P + + G V + T+ + K P+D Sbjct: 458 RKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPED 496 Score = 65.5 bits (158), Expect = 7e-10 Identities = 78/427 (18%), Positives = 155/427 (36%), Gaps = 63/427 (14%) Query: 481 ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540 ER+ E+ER + +++D+ +K + +E G R ++T Sbjct: 96 ERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQT------------ 143 Query: 541 VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600 D Q + D+ K+ E Q D ++ E Sbjct: 144 -----------DGQRERERQRDAEKERER------------QTDRERQRQTERNRQKERE 180 Query: 601 KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTE 660 ++K+ E + E ++ + E + +E + E + ET+ + QT+ + + +T Sbjct: 181 REKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTER 240 Query: 661 CKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDG 720 ++ ++ + E + + ++ R K R +K + R E + Sbjct: 241 EREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDR----- 295 Query: 721 HPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVS 780 ET + K++ + E +++N R + + R +K Sbjct: 296 --ETER----------KRERQRERERERERNRKRERERERERERERQRETERDREKERER 343 Query: 781 KHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRV 840 K K+ T+ D R + E +Q + E R ++Q + +R E ER D+ R Sbjct: 344 KRKRQTEMDRERNRQTGREGRRQ-----AERERERERERDRQSAREREERER---DRDRD 395 Query: 841 RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900 R+ E R + ++ G + + ER+ ES RER E++ + R +Q D Sbjct: 396 RQKERERQTEKDRDGQRETEKQR---EREKDRESERGRERGREREKQKGRERDRERQTDR 452 Query: 901 NKSRSDK 907 R K Sbjct: 453 QAGRQRK 459 Score = 61.6 bits (148), Expect = 1e-08 Identities = 85/464 (18%), Positives = 186/464 (40%), Gaps = 44/464 (9%) Query: 731 GRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDS 790 G E+P+++G + D D + + +K+ E + K+ T+ ++ Sbjct: 32 GSQESPRRRGLGQA----------------HKDADGDDRERNRQKERERRREKRQTERET 75 Query: 791 PRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSS 850 R + R E K R R +RD + +++ E +R R ++ R R+ E R + Sbjct: 76 DRKRERRRE--KDRHRKRDRHRERQRDREKERERQTDRERDRQR-EKERNRQKERERETE 132 Query: 851 RNEHGIKSDSSKTD-KLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLG 909 R G + +TD + ER+ + ++ RER + E++ + + R K+ + K+R ++ Sbjct: 133 R--EGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRE 190 Query: 910 FKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNV 969 + K++K + + + + + + E R + K +++ Sbjct: 191 RERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQR------KTEREREK 244 Query: 970 TQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLK 1029 E ++ + +DK + D ++ + ++ ++ +DRE + + + Sbjct: 245 QAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQ 304 Query: 1030 PIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEIS 1089 + + + N+ ++ +E E E E E+ + KRKR T ++ + + Sbjct: 305 RERERERERNR-KRERERERERERERQRETERDR---EKERERKRKRQTEMDRERNRQTG 360 Query: 1090 SDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNR 1149 + ++ E R+R D A E EER+R D ++ + G + Sbjct: 361 REGRRQAERERERERER---DRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQ 417 Query: 1150 SPSDSDMEDYSPPPSLSEVARKM-KKKEKQKKRKAYEPKLTPEE 1192 + D E SE R+ +++EKQK R+ + T + Sbjct: 418 REREKDRE--------SERGRERGREREKQKGRERDRERQTDRQ 453 Score = 60.8 bits (146), Expect = 2e-08 Identities = 89/445 (20%), Positives = 171/445 (38%), Gaps = 64/445 (14%) Query: 475 AEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNG 534 AE ER ER++ ER+R ++ + K++ +K +Q+ +E R +E + Sbjct: 155 AEKER-ERQTDRERQRQTERNRQKEREREKNRQERRERE--------RQREKENKTEDRH 205 Query: 535 SRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPE 594 S + + + ++ D +K E Sbjct: 206 SERGRERERERETETETERKRQTDRERDRQRKTER------------------------- 240 Query: 595 NHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQN 654 E K+ S+ E ++ + R E + +R K E + + K + +TE Sbjct: 241 ---EREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE----- 292 Query: 655 ESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETP 714 R TE K+ E ++ NR + + ++ + ET + R + ++K + + E Sbjct: 293 RDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMD 352 Query: 715 KQKSDGHPETPKQKG-DGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPST 773 ++++ +Q G +GR + +++ R E +Q R E + R +R+ + T Sbjct: 353 RERN-------RQTGREGRRQAERERERER-ERDRQSAREREERERDRDRDRQKERERQT 404 Query: 774 EKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERH 833 EK + +++T+ R K +E ++R GR + R+ D ++++D + +R Sbjct: 405 EKDRD---GQRETEKQREREKDRESERGRER--GREREKQKGRERDRERQTDRQAGRQRK 459 Query: 834 RGDQSRVRRPETLRSS------SRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQK 887 R P T RS +R GI+ SS D R G + Sbjct: 460 RSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFPWGRPAKASRGRVAG 519 Query: 888 SRPDSPRV--KQGDSNKSRSDKLGF 910 R PR+ K+G + R GF Sbjct: 520 RRRWEPRLGEKRGQGGEGRRPSGGF 544 Score = 59.7 bits (143), Expect = 4e-08 Identities = 84/503 (16%), Positives = 185/503 (36%), Gaps = 51/503 (10%) Query: 712 ETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPK------QKNEGRPETPKHR-HDN 764 E+P+++ G GD R +++ E R E + +K E R E +HR D Sbjct: 35 ESPRRRGLGQAHKDAD-GDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR 93 Query: 765 RRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQR---------PDGRSVSESLR 815 R+ + +++ + ++D + + R + + E +R DG+ E R Sbjct: 94 HRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQR 153 Query: 816 RDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESG 875 +++ DR + ++ + R E R R + +KT+ + E Sbjct: 154 DAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE 213 Query: 876 DSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHP 935 RE + E+K + D R +Q + + R + + + ++ +R + + + D ++ Sbjct: 214 RERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRD 273 Query: 936 DNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDL 995 + E R + + KR++ +E ++ + +++ + + Sbjct: 274 RRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRET 333 Query: 996 NKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPEL 1055 + + K+RE K + + + + ++ + Q+ E Sbjct: 334 ERDRE-----------------KERERKRKRQTEMDRERNRQTGREGRRQA-------ER 369 Query: 1056 LAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAW 1115 E E + +R+R ++ K E +++D D E R+R K + + Sbjct: 370 ERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERG 429 Query: 1116 EYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKK 1175 R+R R R++ GR R RS +PPP + + + Sbjct: 430 RERGREREKQKGRERDRERQTDRQA---GRQRKRSTL-----YVNPPPRTARSG--VVQS 479 Query: 1176 EKQKKRKAYEPKLTPEEMMDSST 1198 + + + K +PE+ +ST Sbjct: 480 DPNRPTRGIRWKSSPEDPKAAST 502 Score = 58.2 bits (139), Expect = 1e-07 Identities = 79/445 (17%), Positives = 170/445 (38%), Gaps = 52/445 (11%) Query: 749 QKNEGRPETPKHR------HDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALK 802 ++ G E+P+ R D D + + +K+ E + K+ T+ ++ R + R E K Sbjct: 28 RRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRRE--K 85 Query: 803 QRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSK 862 R R +RD + +++ E +R R ++ R R+ E R + R G + + Sbjct: 86 DRHRKRDRHRERQRDREKERERQTDRERDRQR-EKERNRQKERERETERE--GERGRDRQ 142 Query: 863 TD-KLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRT 921 TD + ER+ + ++ RER + E++ + + R K+ + K+R ++ ++ +R Sbjct: 143 TDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQER------RERERQRE 196 Query: 922 EGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGE 981 + NK T H + E R+++ ET++ Sbjct: 197 KENK----TEDRHSERGRE----------------------RERERETETETERKRQTDR 230 Query: 982 PKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKG 1041 +D+ K + + + ++ D ++ +DR+ K + + + + Sbjct: 231 ERDRQRKTERERE-KQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQR 289 Query: 1042 SIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEA-- 1099 ++ E E E E ER + +R+R E+ + E D + + + Sbjct: 290 RTERDRETERKRERQRERERER---ERNRKRERERERERERERQRETERDREKERERKRK 346 Query: 1100 --FESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDME 1157 E R+R+++ + ER+R + R R R R + + Sbjct: 347 RQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEK 406 Query: 1158 DYSPPPSLSEVARKMKKKEKQKKRK 1182 D + + K +E ++ R+ Sbjct: 407 DRDGQRETEKQREREKDRESERGRE 431 Score = 42.4 bits (98), Expect = 0.006 Identities = 68/340 (20%), Positives = 133/340 (39%), Gaps = 27/340 (7%) Query: 850 SRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLG 909 SR G +S + L + H+ GD RER E++ R + + ++ K ++ Sbjct: 27 SRRRPG-SQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKR--ERRR 83 Query: 910 FKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNV 969 K K D+ E + + + D + + R + + +R +D Sbjct: 84 EKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQT 143 Query: 970 TQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLK 1029 + ++ + K++ + ++ + + + +K ++R ++ R K Sbjct: 144 DGQRERERQRDAEKERERQT------DRERQRQTERNRQKEREREKNRQERRERERQREK 197 Query: 1030 PIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYA--E 1087 K + S +G +E E E E+ + + R+R T E+ K A E Sbjct: 198 ENKTEDRHSERG-------RERERERETETETERKR-QTDRERDRQRKTEREREKQAERE 249 Query: 1088 ISSDEDNDSDEAFESSRKRHKKDDDKAWEYE-----ERDRRSSGDHRRSGHSHEGRRSSG 1142 +S+ + + D+ E R R + D + E E +R RR+ D R + E +R Sbjct: 250 RASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERD-RETERKRERQRERE 308 Query: 1143 GGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRK 1182 R RNR + + E E R ++KE+++KRK Sbjct: 309 RERERNRK-RERERERERERERQRETERD-REKERERKRK 346 >gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] Length = 1301 Score = 72.4 bits (176), Expect = 6e-12 Identities = 111/625 (17%), Positives = 205/625 (32%), Gaps = 35/625 (5%) Query: 552 DSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKS 611 DS +S + DSDS + +D+ S D S S+ ++ ++ K +SD S S Sbjct: 584 DSDSSDSSDSDS----SDSSNSSDSSDSSDSSDSSDSSDSS-DSKSDSSKSESDSSDSDS 638 Query: 612 EMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEP 671 + S+S ++S N + ++ +S N ++ + + + + + ++S+ Sbjct: 639 KSDSSDSNSSDSSDNSDSS-DSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN 697 Query: 672 KQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDG 731 + SD+ +D+ ++ S + S ++ S SD + Sbjct: 698 SSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSD 757 Query: 732 RPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTK--SD 789 ++ S ++ + + N DS S S D+ SD Sbjct: 758 SSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSD 817 Query: 790 SPRLKSERAEALKQRPDGRSVSESLRR-------DHDNKQKSDDRGESERHRGDQSRVRR 842 S S + D + S+S D D+ +SD S+ S Sbjct: 818 SDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSS-NS 876 Query: 843 PETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNK 902 ++ SS NE SDSS + +S DS S + + DS N Sbjct: 877 SDSSDSSDSNESSNSSDSSDS---SNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNS 933 Query: 903 SRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIK 962 + SD S +S ++ + S +N + N ++ S + + Sbjct: 934 NSSD----SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSS 989 Query: 963 RDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDRED 1022 D + + ++ + D + + N S D D D Sbjct: 990 DSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSD------SSNSSDS-----SDSSD 1038 Query: 1023 KSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEK 1082 S SS + S S+ S ++ + E + S+ + Sbjct: 1039 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSD 1098 Query: 1083 PKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSG 1142 + SSD + SD + S D + + D +S D S S + SS Sbjct: 1099 SSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSD 1158 Query: 1143 GGRYRNRSPSDSDMEDYSPPPSLSE 1167 + S S SD D S + S+ Sbjct: 1159 SSDSSDSSDS-SDSSDSSDSSNSSD 1182 Score = 71.2 bits (173), Expect = 1e-11 Identities = 114/655 (17%), Positives = 202/655 (30%), Gaps = 41/655 (6%) Query: 518 TGGNRPASQETGSTGNGSRPALMVSIDLHQAGR-VDSQASITQDSDSIKKPEEIKQCNDA 576 + GN A+ E+ + + A S + G DS+ + DSDS Sbjct: 471 SNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTS----------- 519 Query: 577 PVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSS 636 D S + N+ KSD KS+ S+S + + + + ++ SS Sbjct: 520 -------DTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSS 572 Query: 637 ENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETT 696 ++ + ++ + + + N S + + + + +D+K ++ +SE+ Sbjct: 573 DSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESD 632 Query: 697 KSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPE 756 S ++ +S SD + ++ S ++ Sbjct: 633 SSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDS 692 Query: 757 TPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRR 816 + DS S + S SDS S + D S+S Sbjct: 693 SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDS-SN 751 Query: 817 DHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSS----KTDKLERKHRH 872 D+ SD S+ S ++ SS N+ SDSS +D Sbjct: 752 SSDSSDSSDSSNSSDSSDSSDSS-DSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSS 810 Query: 873 ESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNK 932 +S DS + SS S S +S+ S S R++ + S ++ Sbjct: 811 DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDS 870 Query: 933 AHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLV 992 + N ++ S + D D + + + D E Sbjct: 871 SDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSS 930 Query: 993 EDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELP 1052 ++ N S D D D S SS + S S+ S D S Sbjct: 931 DNSN------------SSDSSNS--SDSSDSSDSSNSSDSSNSSDSSNSS-DSSDSNSSD 975 Query: 1053 PELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDD 1112 + + + + S+ + + SSD N SD + S D Sbjct: 976 SSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD 1035 Query: 1113 KAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSE 1167 + + D S D S +S + SS + S S SD D S S+ Sbjct: 1036 SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDS-SDSSDSSESSDSSD 1089 Score = 69.7 bits (169), Expect = 4e-11 Identities = 157/926 (16%), Positives = 284/926 (30%), Gaps = 65/926 (7%) Query: 257 DDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILL 316 DD DSS +N+ S P+ P K S+ S+ P D + Sbjct: 289 DDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSK------SEENSAGIPEDNGSQRIE 342 Query: 317 DSPERKQKKQKKMK-----------LGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRV 365 D+ + ++ K+++ +GK + + E I PS + +T + + Sbjct: 343 DTQKLNHRESKRVENRITKESETHAVGKSQDKGIE-------IKGPSSGNRNITKEVGKG 395 Query: 366 RSSDMDQ-QEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQE 424 D+ Q MI G NV N++ PGQ S+ + + S Sbjct: 396 NEGKEDKGQHGMILG--KGNVKTQGEVVNIEGPGQKSEPG---NKVGHSNTGSDSNSDGY 450 Query: 425 QTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPI-YDEVELDALAEIERIERE 483 + + N+S + + ++ S +G Y+ E ++ Sbjct: 451 DSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDE----------SKD 500 Query: 484 SAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSI 543 + + E D D DS G GN + G S Sbjct: 501 NGNGSDSKGAEDDDSDSTSDTNNSDSN----GNGNNGNDDNDKSDSGKGKSDSSDSDSSD 556 Query: 544 DLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKK 603 + + DS S + DS+S + + D S S+ + Sbjct: 557 SSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDS 616 Query: 604 SDPELSKSEMKQSES--RLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTEC 661 SD SKS+ +SES ++SK + + + SS+N + + + + + + Sbjct: 617 SDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDN-------SDSSDSSNSSNSSDSS 669 Query: 662 KQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGH 721 ++S+ + + SD+ + + N+ S + ++ + SD Sbjct: 670 DSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSS 729 Query: 722 PETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSK 781 + ++ S ++ + + DS S S Sbjct: 730 NSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSS 789 Query: 782 HKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVR 841 + D+ S S + D S D N S D S D S Sbjct: 790 NSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSS-DSSDSSDSS 848 Query: 842 RPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSN 901 SS+R++ SDSS D + + +S DS + S DS DS+ Sbjct: 849 DGSDSDSSNRSDSSNSSDSS--DSSDSSNSSDSSDSSDSNESSNSSDSSDSS--NSSDSD 904 Query: 902 KSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKI 961 S S S +S +E + S ++N + N ++ S N Sbjct: 905 SSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSN 964 Query: 962 KRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDRE 1021 D + + ++ + D + + + S D Sbjct: 965 SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024 Query: 1022 DKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTVNE 1081 S +S + S + S D S + + + + + S+ + Sbjct: 1025 SDSSNSSDSSDSSDSSDSSDSSDSSDSSD-----SSNSSDSSDSSDSSDSSDSSDSSDSS 1079 Query: 1082 KPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSS 1141 + SSD N SD + S D + + D +S D S S + SS Sbjct: 1080 DSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1139 Query: 1142 GGGRYRNRSPSDSDMEDYSPPPSLSE 1167 + S S SD D S S+ Sbjct: 1140 NSSDSSDSSES-SDSSDSSDSSDSSD 1164 Score = 65.1 bits (157), Expect = 9e-10 Identities = 136/805 (16%), Positives = 255/805 (31%), Gaps = 60/805 (7%) Query: 129 SQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMP 188 S + S +S + + + S SS +S N +S S + S + Sbjct: 540 SDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSS 599 Query: 189 YSHPSSYTTHPQ-MQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDY 247 S SS ++ +S SS + ++ D+ S S +S ++ +D+ + S D Sbjct: 600 NSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDS 659 Query: 248 LHMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSP 307 + + SSD DSS +++S S S + S S S Sbjct: 660 SNSSN--SSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSS--DSSDSDSSDS 715 Query: 308 RDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRS 367 D DS D + S+ + D SS S DS+ S Sbjct: 716 SDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSD--SSDSSDSSN---------S 764 Query: 368 SDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTA 427 SD D ++SN S+++ N +S + D + +++ + + Sbjct: 765 SDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNS----SDSSNSSDSSDSSDSSDSDS 820 Query: 428 FLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIE 487 N+S ++ +S N S D + D+ Sbjct: 821 -----------SNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSS------------N 857 Query: 488 RERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQ 547 R S D DS + + +S + S+ + S + S Sbjct: 858 RSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDS--- 914 Query: 548 AGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPE 607 S +S + DS + +D+ S D S S+ ++ SD Sbjct: 915 -----SDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 969 Query: 608 LSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNEST 667 S S S ++S + + + SS++ + + + + + + + ++S+ Sbjct: 970 DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSS-NSSDSSDSSDSSDSSNSSDSSNSSDSS 1028 Query: 668 IVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQ 727 + + SD+ + + ++ S + ++ S SD + Sbjct: 1029 NSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088 Query: 728 KGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTK 787 ++ S ++ + + DS S S D+ Sbjct: 1089 DSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSS 1148 Query: 788 SDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLR 847 S S + D S+S D N S D +S ++ Sbjct: 1149 ESSDSSDSSDSSDSSDSSDSSDSSDS--SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1206 Query: 848 SSSRNEHGIKSDSS-KTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSD 906 SS ++ SDSS +D + +ES DS + S + + DS DS+ S SD Sbjct: 1207 SSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSS--DSSDSSDSTSD 1264 Query: 907 KLGFKSPTSKDDKRTEGNKSKVDTN 931 + K GN + D++ Sbjct: 1265 S---NDESDSQSKSGNGNNNGSDSD 1286 Score = 60.1 bits (144), Expect = 3e-08 Identities = 121/725 (16%), Positives = 238/725 (32%), Gaps = 37/725 (5%) Query: 220 DNKVSGPLSGNSANHHADNPRHGSSEDYLHMVHRLSSDDGDSSTMRNAASFPLRSPQPVC 279 DN S G S + +D+ +S D SSD DS + + +S S Sbjct: 536 DNDKSDSGKGKSDSSDSDSSDSSNSSD--------SSDSSDSDSSDSNSSSDSDSSDSDS 587 Query: 280 SPAGSEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQS 339 S + + S S S S D DS + K K D +S Sbjct: 588 SDSSDSDSSDSSN-----SSDSSDSSDSSDSSDSS--DSSDSKSDSSKSESDSSDSDSKS 640 Query: 340 EKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQ 399 + + SS + DS+ + + SSD D S ++SN S++ + + Sbjct: 641 DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSE 700 Query: 400 TS-KTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQ 458 +S + + D + +++ S ++ + ++S ++ +S + Sbjct: 701 SSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 760 Query: 459 ISQQGPIYDEVEL----DALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEA 514 S D + D+ + + ++ + S + DS ++ Sbjct: 761 SSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDS 820 Query: 515 GGATGGNRPASQETGSTGNGSRPALMVS--IDLHQAGRVDSQ-ASITQDSDSIKKPEEIK 571 ++ + + S + S + S D + R DS +S + DS + Sbjct: 821 SNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSS 880 Query: 572 QCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLV 631 +D+ S D S S+ + ++ SD S + SES + S N N Sbjct: 881 DSSDSNESSNSSDSSDSSNSSDSDSSDS-SNSSDSSDSSNSSDSSES--SNSSDNSNSSD 937 Query: 632 ETKSSENKLETKVETQTEELKQNES-RTTECKQNESTIVEPKQNENRLSDTKPNDNKQNN 690 + SS++ + ++ ++S +++ + S+ N + SD+ + + ++ Sbjct: 938 SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDS 997 Query: 691 GRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQK 750 S + ++ S SD + ++ S Sbjct: 998 SDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNS 1057 Query: 751 NEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSV 810 ++ + + DS S S D+ S S + D Sbjct: 1058 SDSSDSSDSSDSSDSSDSSDSSD------SSESSDSSDSSNSSDSSDSSDSSDSSDSSDS 1111 Query: 811 SESL-RRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSS-KTDKLER 868 S+S D N S D +S + ++ SS ++ SDSS +D + Sbjct: 1112 SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDS 1171 Query: 869 KHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKV 928 +S +S + S + DS DS+ S S S D + + Sbjct: 1172 SDSSDSSNSSDSSDSSDSSDSSDSS--DSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1229 Query: 929 DTNKA 933 D+N++ Sbjct: 1230 DSNES 1234 Score = 50.8 bits (120), Expect = 2e-05 Identities = 112/540 (20%), Positives = 183/540 (33%), Gaps = 61/540 (11%) Query: 664 NESTIVEPK-QNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHP 722 NE I+E +NE S+ P N + NG E + P T + G SDG P Sbjct: 195 NEDEIIENSCRNEGNTSEITPQINSKRNGTKE-AEVTPGTGEDAG-------LDNSDGSP 246 Query: 723 -----ETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKP 777 + + +G G E + + EG+ + HD+ S E Sbjct: 247 SGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYD 306 Query: 778 EVSKH--KQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDR--GESERH 833 K + D E + + + + + ++ + +H ++ ++R ESE H Sbjct: 307 PEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETH 366 Query: 834 RGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRH----------ESGDSRERPSS 883 +S+ + E SS N + K + E K +H G+ Sbjct: 367 AVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGP 426 Query: 884 GEQKSRPDSPRVKQGDSNK-SRSDKLGFKS------------PTSKDDKRTEGNKSKVDT 930 G QKS P + K G SN S S+ G+ S P S D+ + + Sbjct: 427 G-QKSEPGN---KVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESD 482 Query: 931 NKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKG---EPKDKVE 987 N + A + S S N K D D + T +T + G D + Sbjct: 483 NNSSSRGDASYNS----DESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDND 538 Query: 988 KIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPS--KSNKGSIDQ 1045 K + + + S D D D + SS + S S+ S D Sbjct: 539 KSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDS 598 Query: 1046 SVLKELPPELLAEIESTMPLCERVKMNKRK----RSTVNEKPKYAEISSDEDNDSDEAFE 1101 S + + S K + K S + K ++ +S + +D+ ++ + Sbjct: 599 SNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSD 658 Query: 1102 SSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRS-PSDSDMEDYS 1160 SS + D + + D SS D S S + SS + S SDSD D S Sbjct: 659 SSNSSNSSDSSDS--SDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSS 716 Score = 43.5 bits (101), Expect = 0.003 Identities = 102/698 (14%), Positives = 206/698 (29%), Gaps = 22/698 (3%) Query: 129 SQNSMHSSPASSNYQQTTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMP 188 S S S S + ++ S+S S + S N +S S + Sbjct: 626 SSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSN 685 Query: 189 YSHPSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYL 248 S S + ++S SS + D+ S +S+N + SS+ Sbjct: 686 SSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSD 745 Query: 249 HMVHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPR 308 SSD DSS N++ S S + + S S S Sbjct: 746 SSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSN 805 Query: 309 DVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSS 368 DS + D + S + D S + + R SS Sbjct: 806 SSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSS 865 Query: 369 DMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAF 428 D D + ++S+ S+++ N +S + + D + N++ Sbjct: 866 DSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNS--SDSDSSDSSNSSDSSDSS----- 918 Query: 429 LPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIER 488 N+S +++ +S N S D + ++ S Sbjct: 919 -----------NSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSS---N 964 Query: 489 ERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQA 548 S + D DS + + +S + S+ + S D + Sbjct: 965 SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024 Query: 549 GRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPEL 608 + + + SDS + + + S + S S + ++ E Sbjct: 1025 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES 1084 Query: 609 SKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTI 668 S S + S ++S + + + SS++ + ++ ++S + N S Sbjct: 1085 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 1144 Query: 669 VEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQK 728 + ++ + + +D+ ++ S+++ S ++ S SD + Sbjct: 1145 SDSSESSDSSDSSDSSDSSDSSDSSDSSDSS-DSSNSSDSSDSSDSSDSSDSSDSSDSSD 1203 Query: 729 GDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKS 788 ++ S ++ + DS S S D+ S Sbjct: 1204 SSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTS 1263 Query: 789 DSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDD 826 DS ++++ +G N SDD Sbjct: 1264 DSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSDD 1301 Score = 34.3 bits (77), Expect = 1.7 Identities = 47/219 (21%), Positives = 77/219 (35%), Gaps = 18/219 (8%) Query: 2458 SVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSED 2517 S S S+ S S D SS S ++ +S + S S DS SDS D Sbjct: 719 SNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSD 778 Query: 2518 DINSVMKCLPENSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYD 2577 NS NS+ + +N S N SDS S S+S+ D Sbjct: 779 SSNSSDSNDSSNSSDSSDSSNSSDS-----------SNSSDSSDS--SDSSDSDSSNSSD 825 Query: 2578 KAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQYLDFKLLMEHLDPDEEEEEG 2637 + + + + + D SD ++ ++ RS D + D + Sbjct: 826 SSNSSDSSDSSNSSDSSD--SSDSSDGSDSDSSNRSDSSNSSDSS---DSSDSSNSSDSS 880 Query: 2638 EVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGED 2676 + S S + N + +S S +++ + D SD + Sbjct: 881 DSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSN 919 Score = 33.1 bits (74), Expect = 3.8 Identities = 21/68 (30%), Positives = 29/68 (42%) Query: 2454 DITLSVSGSNLLQSFKESMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDS 2513 D + S S S+ S S D +SS S ++ SDS + + DS + S Sbjct: 673 DSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSS 732 Query: 2514 DSEDDINS 2521 DS D NS Sbjct: 733 DSSDSSNS 740 >gi|104526627 triadin [Homo sapiens] Length = 729 Score = 72.0 bits (175), Expect = 7e-12 Identities = 121/591 (20%), Positives = 220/591 (37%), Gaps = 75/591 (12%) Query: 283 GSEGTPKGS--RPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSE 340 G E T KG PPL + + ++ P + K+K++ K K+ + EK + + Sbjct: 124 GDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPE-K 182 Query: 341 KAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQT 400 KA + I K TK TL + ++ ++ E+ E + + + Sbjct: 183 KATHKEKIEKKEKPETK-TLAKEQKKAKTAEKSEEKTKK-EVKGGKQEKVKQTAAKVKEV 240 Query: 401 SKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQIS 460 KTP P++ AA +Q+ + + + P +Q S Sbjct: 241 QKTPSKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQAS 300 Query: 461 QQGPIYDEVELDALAEIERIERESAIERERFSKEVQD-KDKPLKKRKQDSYPQEAGGATG 519 + P +E E E+ + E + E KE +D K K K+ D +E G A+ Sbjct: 301 RPTPASPALEEK---EGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKAS- 356 Query: 520 GNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVS 579 T G+ V I A + D + +DS KKP E++Q Sbjct: 357 ----------ETKQGT-----VKIAAQAAAKKDEKK---EDSKKTKKPAEVEQPK----- 393 Query: 580 VLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENK 639 G + E H E P K E S KQ +++ +K + K+ K Sbjct: 394 -------GKKQEKKEKHVE-PAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGK 445 Query: 640 LETKV-ETQTEELKQNESRTTECKQNESTIVEPKQNE--NRLSDTKPNDNKQNNGRSETT 696 E K +T +E+++ +S T + ++ K+ + L + +P K Sbjct: 446 KEEKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGK 505 Query: 697 KSRPETPKQKG--ESRPETPKQKSDGHP--------------ETPKQKGDGRPETPKQKG 740 + +P+ P+ +G E +PE P+ K + P + K G+PE K Sbjct: 506 EVKPKPPQLQGKKEEKPE-PQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQ 564 Query: 741 --------ESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTE------KKPEVSKHKQDT 786 ++P+ K+ E P + D + + K ++E KK E+S+ + Sbjct: 565 VKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKE 624 Query: 787 KSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQ 837 K+D L+ E+ K+ +V+++ + +K D + G + Sbjct: 625 KADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTE 675 Score = 68.9 bits (167), Expect = 6e-11 Identities = 113/566 (19%), Positives = 217/566 (38%), Gaps = 74/566 (13%) Query: 582 QEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESK-------PNENRLVETK 634 +ED G + E P +K + K+E ++ R ++K + ++ E + Sbjct: 119 EEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKE 178 Query: 635 SSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSE 694 E K K + + +E + ++ E K+ ++ ++ + + K KQ + + Sbjct: 179 KPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVK 238 Query: 695 TTKSRPETPKQKGESRPETPKQKSDGHPE----------------TPKQKGDGRPETPKQ 738 + P PK+K E + + K + + P Q P P + Sbjct: 239 EVQKTPSKPKEK-EDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTE 297 Query: 739 KGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERA 798 + SRP TP E K + + + S EK+ K +++T D + + +A Sbjct: 298 QA-SRP-TPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKA 355 Query: 799 EALKQRPDGRSVSESLRRDH--DNKQKSDDRGESERHRG-DQSRVRRPETLRSSSRNEHG 855 KQ + + ++D ++ +K+ E E+ +G Q + + S + EH Sbjct: 356 SETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHS 415 Query: 856 IKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTS 915 + SD K ER + E G + + +K + V+Q + R +K G S Sbjct: 416 VPSDKQVKAKTERA-KEEIGAVSIKKAVPGKKEEKTTKTVEQ----EIRKEKSGKTSSIL 470 Query: 916 KDDKRTEGNKSKVDTN--KAHPDNKAEFPSYLLGGR--------SGALKNFVIPKIKRDK 965 KD + +G + KV + + P+ K + G G + P+IK++ Sbjct: 471 KDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEA 530 Query: 966 DGNVTQET----------KKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQK 1015 ++++ +K G+P++KV K + K AKP K Sbjct: 531 KPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKP-------------K 577 Query: 1016 LIKDREDKSRS--SLKPIKNKPSKSNKGSIDQSVLKELP-PELLAEIESTMPLCERVKMN 1072 K E + R S+K K KP+ + +S K+ E ++ ++ M K++ Sbjct: 578 PTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREEKVS 637 Query: 1073 KRKRS----TVNEKPKYAEISSDEDN 1094 RK S V + K A +S D ++ Sbjct: 638 TRKESLQLHNVTKAEKPARVSKDVED 663 Score = 47.0 bits (110), Expect = 3e-04 Identities = 74/347 (21%), Positives = 139/347 (40%), Gaps = 39/347 (11%) Query: 873 ESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGF---KSPTSKDDKRTEGNKSKVD 929 E D E GE D P +++ + +K +++K K T K E K KV Sbjct: 120 EDDDGDEDTDKGEI----DEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKV- 174 Query: 930 TNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKI 989 K P+ KA + K + K+ K ++E K E+KG ++KV++ Sbjct: 175 REKEKPEKKATHKEKIEKKEKPETKTLAKEQ-KKAKTAEKSEEKTKKEVKGGKQEKVKQT 233 Query: 990 GL-VEDLNKG-AKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSN-KGSIDQS 1046 V+++ K +KP K++EDK ++++ + K + + ID Sbjct: 234 AAKVKEVQKTPSKP----------------KEKEDKEKAAVSKHEQKDQYAFCRYMIDIF 277 Query: 1047 VLKELPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKR 1106 V +L P I +P E+ + EK E +++ S K+ Sbjct: 278 VHGDLKPGQSPAIPPPLPT-EQASRPTPASPALEEK-------EGEKKKAEKKVTSETKK 329 Query: 1107 HKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLS 1166 +K+D K + E++ + + G + E ++ + + + D ED + Sbjct: 330 KEKEDIK--KKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPA 387 Query: 1167 EVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRFTASIENILDNL 1213 EV + K K+++KK K EP +P++ + K+ A E + + Sbjct: 388 EVEQP-KGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEI 433 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 71.6 bits (174), Expect = 1e-11 Identities = 142/913 (15%), Positives = 340/913 (37%), Gaps = 85/913 (9%) Query: 321 RKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQEDMISGV 380 R+QK+Q++ + + +EQSEK + +D R + +E+ + Sbjct: 137 RRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSC 196 Query: 381 ENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQN 440 + +T + P Q R L + ++E+ Q V Q+ Sbjct: 197 KGH---------------ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEE 241 Query: 441 TSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQD--- 497 ++ +T + + ++++ ++ P + ++ ++ER+ + RER +E Q Sbjct: 242 EEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE-LRRERQEEEQQQQRL 300 Query: 498 -KDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQAS 556 +++ L++++++ ++ R QE R L + + Sbjct: 301 RREQQLRRKQEEERREQQ-----EERREQQERREQQEERREQ-----QLRREQEERREQQ 350 Query: 557 ITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQS 616 + ++ + ++ +++++ + Q L+ + E ++ + ++++ Sbjct: 351 LRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 410 Query: 617 ESRLAESKPNENRLVETKSSENKLETKVETQTEE---LKQNESRTTECKQNESTIVEPKQ 673 + E + + + + E + E K E + E ++ E R K+ E T E + Sbjct: 411 QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEET--ERHE 468 Query: 674 NENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRP 733 E R K + ++ R K E +++ E R + +++ + E + K Sbjct: 469 QERRKQQLKRDQEEER--RERWLKLEEEERREQQERREQQLRREQEERRE-QRLKRQEEE 525 Query: 734 ETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKH-----KQDTKS 788 E +Q+ S + +++ E R + K + R + + K E + K++ + Sbjct: 526 ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEER 585 Query: 789 DSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERH----RGDQSRVRRPE 844 RLK E+ E L+QR V + + ++ + E ER + ++ RR + Sbjct: 586 RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQ 645 Query: 845 TLR--SSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQ----- 897 LR R E +K + + ++LE++ + E + R E++ R+K Sbjct: 646 QLRREQQERREQRLKREEEE-ERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKW 704 Query: 898 ----GDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGAL 953 +R K+ + + +R + + K ++ + E ++ Sbjct: 705 QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQR 764 Query: 954 KNFVIPKIKRDKDGNVTQ---------ETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVV 1004 ++F +K Q E ++ +++ E + + E+ L E+ K + Sbjct: 765 RDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR--- 821 Query: 1005 LQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMP 1064 Q+ + + +++ E R + + + + + + + E + + Sbjct: 822 RQRREREKELQFLEEEEQLQRRE----RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ 877 Query: 1065 LCERVKMNKRKRSTVNEKPKYAEISSDED---NDSDEAFESSRKRHKKDDDKAWEYEERD 1121 L E KR+R T+ KP E E + +E + + ++ ++ +Y E + Sbjct: 878 LEEE---RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE 934 Query: 1122 RRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKR 1181 + + + E RR R + E+ L E K +++E++KK Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE----QLLGEEPEKRRRQEREKKY 990 Query: 1182 KAYEPKLTPEEMM 1194 + E EE + Sbjct: 991 REEEELQQEEEQL 1003 Score = 69.7 bits (169), Expect = 4e-11 Identities = 110/674 (16%), Positives = 268/674 (39%), Gaps = 59/674 (8%) Query: 543 IDLHQAGRVDSQASITQD----SDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPE 598 +D + R D + S+ QD D + +Q + P ++ + E + Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154 Query: 599 TPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEE------LK 652 + K++ L + + ++ + L + E ++ E +L++ +TEE L+ Sbjct: 155 SEKQE---RLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLR 211 Query: 653 QNESRTTECKQNESTIVEPKQNENRL---SDTKPNDNKQNNGRSETTKSRPETPKQKGES 709 + E K E + ++ ++R+ + K ++ R E K + E P+++ E Sbjct: 212 RRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQREL 271 Query: 710 RPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSG 769 + E + + E +++ + E +Q+ + +++ E R E + R + + Sbjct: 272 QEEEEQLRKLERQELRRERQE--EEQQQQRLRREQQLRRKQEEERREQQEERREQQERRE 329 Query: 770 KPSTEKKPEVSKHKQDTKSDSPRLKSE---RAEALKQRPDGRSVSESLRRDHDNKQKSDD 826 + ++ ++ + +++ + R + E R + L++ + + LRR+ +++ Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQL 389 Query: 827 RGESERHRGDQSRVRRPETLRSSS--RNEHGIKSDSSKTDKLERKHRHESG---DSRERP 881 R E + R Q +RR + LR R E ++ + + E + RHE + RE+ Sbjct: 390 RREQQLRREQQ--LRREQQLRREQQLRREQQLRREQQLRREQEEE-RHEQKHEQERREQR 446 Query: 882 SSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEF 941 EQ+ R D + ++ + + ++++R K + + + + + + Sbjct: 447 LKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ- 505 Query: 942 PSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKME--------MKGEPKDKVEKIGLVE 993 +++R+++ Q K+ E ++ E + + E+ E Sbjct: 506 ------------------QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERRE 547 Query: 994 DLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPP 1053 L K + + Q+ Q+L +++E++ LK + + + K ++ + + L Sbjct: 548 QLLKREEEKRLEQERR---EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR 604 Query: 1054 ELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDK 1113 E + +E +R+K + + + K E + R++ K +++ Sbjct: 605 EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664 Query: 1114 AWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMK 1173 E+R +R + RR E + R ++R P + S+V + + Sbjct: 665 EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724 Query: 1174 KKEKQKKRKAYEPK 1187 K+E Q++R+ E K Sbjct: 725 KQEGQRRRQEQEEK 738 Score = 63.5 bits (153), Expect = 3e-09 Identities = 150/900 (16%), Positives = 344/900 (38%), Gaps = 92/900 (10%) Query: 314 ILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMDQQ 373 + + E++ +K++ + ++EK Q E+ + + KL + R + +QQ Sbjct: 237 VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQ 296 Query: 374 EDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQ 433 + + + + + Q + + Q+ R Q +QE+ + Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERRE---QQLRREQEE------RR 347 Query: 434 VPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSK 493 L++ ++ Q Q +++ QQ L +++ RE + RE+ + Sbjct: 348 EQQLRREQEEERREQQLRREQEEERREQQ-----------LRREQQLRREQQLRREQQLR 396 Query: 494 EVQD--KDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRV 551 Q +++ L++ +Q Q+ R +E H+ R Sbjct: 397 REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHE-------------QKHEQERR 443 Query: 552 DSQASITQDS--DSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELS 609 + + Q+ D +K+ EE ++ QE LK E K + E Sbjct: 444 EQRLKREQEERRDWLKREEETERHE-------QERRKQQLKRDQEEERRERWLKLEEEER 496 Query: 610 KSEMKQSESRLA-ESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTEC-KQNEST 667 + + ++ E +L E + + ++ + E +L+ ++ ++ + ++ E R + K+ E Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK 556 Query: 668 IVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQ 727 +E ++ E RL + Q R E + R + K++ E R E ++ + ++ Sbjct: 557 RLEQERREQRLKREQEERRDQLLKREE--ERRQQRLKREQEERLEQRLKREEVERLEQEE 614 Query: 728 KGDGRPETPKQKGESRPETPK-QKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDT 786 + + R + + + E R + K ++ E R + R R + E++ E + + Sbjct: 615 RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR 674 Query: 787 KSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGES--ERHRGDQSRVRRPE 844 + + R + E AE +++ R S + + ++D R R R + + RR E Sbjct: 675 EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE 734 Query: 845 TLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS---- 900 R E ++ ER HR + + + R + + ++ S R +Q S Sbjct: 735 QEEKRRRRESELQWQEE-----ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPP 789 Query: 901 -NKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIP 959 + R +L + ++ + + K + + + E L + Sbjct: 790 LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKEL--QFLEEEEQLQRRERAQ 847 Query: 960 KIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKG-----AKPVVVLQKLSLDDVQ 1014 +++ ++DG + ++ ++ + + +D+ + L E+ + AKP LQ+ + Q Sbjct: 848 QLQEEEDG-LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP--ALQEQLRKEQQ 904 Query: 1015 KLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKR 1074 L ++ E+ R + K + + + ++ L++ +LL E ER K ++ Sbjct: 905 LLQEEEEELQREERE--KRRRQEQERQYREEEQLQQEEEQLLRE--------EREKRRRQ 954 Query: 1075 KRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHS 1134 +R K K + + E KR +++ +K + EE + + + Sbjct: 955 ERERQYRKDKKL-----QQKEEQLLGEEPEKRRRQEREKKYR-EEEELQQEEEQLLREER 1008 Query: 1135 HEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMM 1194 + RR +YR + + E L E K + +E++++ + E EE + Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQL-----LREEREKRRLQERERQYREEEELQQEEEQL 1063 Score = 63.5 bits (153), Expect = 3e-09 Identities = 129/748 (17%), Positives = 278/748 (37%), Gaps = 103/748 (13%) Query: 454 QNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQE 513 + +QQ+ ++ E L E ER+++ E++ ++ + +++ LK+ ++ QE Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561 Query: 514 AGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQC 573 Q R L+ + + R+ + + + K EE+++ Sbjct: 562 R---------REQRLKREQEERRDQLLKREEERRQQRLKREQE--ERLEQRLKREEVERL 610 Query: 574 NDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVET 633 E E K+ +PE + + E + + R + Sbjct: 611 EQ------------------EERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652 Query: 634 KSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNE------NRLSDTKPNDNK 687 + E +L K E + E L+Q R E ++ E + E +Q + +R+ + Sbjct: 653 ERREQRL--KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLES 710 Query: 688 QNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESR---- 743 + + R SRP KQ+G+ R + ++K + + + R +Q+ E R Sbjct: 711 EADARQSKVYSRPR--KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFT 768 Query: 744 --------PETPKQKNEGRPETPKHRHDNRRDSGKPSTEKK--PEVSKHKQDTKSDSPRL 793 E +Q+ RP + R R + E++ PE + +Q + R Sbjct: 769 WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828 Query: 794 KSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQ--------SRVRRPET 845 K + +++ R ++ L+ + D Q+ +R S+ R DQ R RR T Sbjct: 829 KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888 Query: 846 LRSSSRNEHGIKSDSSKTDKLERKHRHESGDSR-----ERPSSGEQKSRPDSPRVKQGDS 900 L + + ++ + + E + + E + R ER E++ + + ++ + + Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREER 948 Query: 901 NKSRSDKLGFKSPTSKDDKRTEGNKSKV------DTNKAHPDNKAEFPSYLLGGRSGALK 954 K R + + + DK+ + + ++ + + K L L+ Sbjct: 949 EKRRRQE---RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLR 1005 Query: 955 NFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQ 1014 + KR + Q KK E++ E + + + L + + ++L ++ Q Sbjct: 1006 E---EREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ 1062 Query: 1015 KLIKDREDKSRSSLKP---------------IKNKPSKSNKGSIDQSVLKELPPELLAEI 1059 L ++RE + R L+ ++ +P K + ++ +E EL E Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE--EELQQEE 1120 Query: 1060 ESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEE 1119 E + R + KR+R + +Y E + + E KR +++ ++ +Y E Sbjct: 1121 EQLL----REEREKRRRQELER--QYREEEEVQQEEEQLLREEPEKRRRQELER--QYRE 1172 Query: 1120 RDRRSSGDHRRSGHSHEGRRSSGGGRYR 1147 + + + E RR +YR Sbjct: 1173 EEELQQEEEQLLREEQEKRRQERERQYR 1200 Score = 60.1 bits (144), Expect = 3e-08 Identities = 116/749 (15%), Positives = 281/749 (37%), Gaps = 73/749 (9%) Query: 481 ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALM 540 E E + ER + +Q++++ + R+++ QE G R + R L Sbjct: 1029 EEEQLLREEREKRRLQERER--QYREEEELQQEEEQLLGEERETRR---------RQELE 1077 Query: 541 VSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETP 600 + + + + + ++ + ++ E +QC + LQ++ L+ E Sbjct: 1078 RQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE--EELQQEEEQLLREEREKRRRQE 1135 Query: 601 KKKSDPELSKSEMKQSESRLAESKPNENRLVETKSS---ENKLETKVET--QTEELKQNE 655 ++ E + E++Q E +L +P + R E + E +L+ + E + E+ K+ + Sbjct: 1136 LERQYRE--EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193 Query: 656 SRTTECKQNESTIVEPKQ----NENRLSDTK-----PNDNKQNNGRSETTKSRPETPKQK 706 R + ++ E + ++ +E++ SD K +N + + E +Q Sbjct: 1194 ERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253 Query: 707 GESRPETPKQKSD-GHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNR 765 +S+ + + D H +Q+ D E + + R +++ E + R D + Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK 1313 Query: 766 RDSGKPSTEKKPEVSKHKQDTKS---DSPRLKSERAEA--LKQRPDGRSVSESLRRDHDN 820 K ++ E + +Q+T + +L ER E +Q D + E LR Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQG 1373 Query: 821 KQKSDDRGESERHRGDQSRVRRPETLRSSSRNEH-------GIKSDSSKTDKLERKHRHE 873 ++ ++ R ++ ++ + LR R + + + + + ER + Sbjct: 1374 RKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR 1433 Query: 874 SGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKA 933 + + R E+K + +++Q K R ++ + + R E ++ ++ + Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493 Query: 934 HPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVE 993 + + +RD+ QE + E + + ++ +++ + Sbjct: 1494 ------------------------LRRQERDRKFR-EQELRSQEPERKFLEEEQQLHRQQ 1528 Query: 994 DLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPP 1053 K + L++ ++ +DR+ + L+ + + S + + L+E Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKV 1588 Query: 1054 ELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDE----DNDSDEAFESSRKRHKK 1109 + M ++++ + ++ E+ + + DE + + + R R Sbjct: 1589 RRQEQERKFMEDEQQLRRQEGQQQLRQERDR--KFREDEQLLQEREEQQLHRQERDRKFL 1646 Query: 1110 DDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVA 1169 +++ +ER+++ D R E G + R D + E Sbjct: 1647 EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE 1706 Query: 1170 RKMKKKEKQKKRKAYEPKLTPEEMMDSST 1198 RK ++E+Q +R+ E K EE + T Sbjct: 1707 RKFLQEEQQLRRQELERKFREEEQLRQET 1735 Score = 58.2 bits (139), Expect = 1e-07 Identities = 157/952 (16%), Positives = 369/952 (38%), Gaps = 97/952 (10%) Query: 298 QSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTK 357 + Q L P + LL S E+++++Q++++ ++++E+ E+ + ++ + Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLR--REQQERREQRLKRE------EEEER 667 Query: 358 LTLRLSRVRSSDMDQQEDMISGVEN------SNVSENDIPFNVQYPGQTSKTPITP---- 407 L RL R + +QE E S + + + + SK P Sbjct: 668 LEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727 Query: 408 -------QDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQIS 460 Q+ R ++ Q+E+ A Q Q+ Q + + +Q++S Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAH--RQQQEEEQRRDFTWQWQAEEKSERGRQRLS 785 Query: 461 QQGPIYDEVELDALAEIERIERESAI-----ERERFSKEVQDKDKPL-----------KK 504 + P+ ++ E AE ER +RE E+E+ ++ ++++K L ++ Sbjct: 786 ARPPLREQRERQLRAE-ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844 Query: 505 RKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQDSDSI 564 R Q +E G R SQE ++ + R + + + + Sbjct: 845 RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRW-----QLEEERKRRRHTLYAKPALQEQL 899 Query: 565 KKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESK 624 +K +++ Q + + + + + + E ++ + +L + E ++ + E + Sbjct: 900 RKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ 959 Query: 625 PNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPN 684 +++ ++ K + E + + +E ++ E +Q E ++ ++ + R + + Sbjct: 960 YRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE-- 1017 Query: 685 DNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRP 744 +Q + E + + +++ E R +++ E +Q E + GE R Sbjct: 1018 --RQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ------EEEQLLGEERE 1069 Query: 745 ETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQR 804 +Q+ E + + + EK+ + +Q + + L+ E + L++ Sbjct: 1070 TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE--ELQQEEEQLLREE 1127 Query: 805 PDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTD 864 + R E L R + +++ + + E E+ ++ RR + L R E ++ + + Sbjct: 1128 REKRRRQE-LERQY--REEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE---E 1181 Query: 865 KLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGN 924 +L R+ + + RER E++ + + + D ++ RSD P +K Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ-RSDLKWQWEP----EKENAVR 1236 Query: 925 KSKVDTNKAHPDNKAEFPSYLLGGRSGA--LKNFVIPKIKRDKDGNVTQETKKMEMKGEP 982 +KV + + L R L++ + + +RD++ QE ++ + + Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDRE----QERRRWQQRDRH 1292 Query: 983 KDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGS 1042 + E++ E K + S ++ Q L ++RE+K R K + + Sbjct: 1293 FPEEEQLEREEQ-----KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347 Query: 1043 IDQSVL------KELPPELLAEIESTMPLCE---RVKMNKRKRSTVNEKP--KYAEISSD 1091 ++ L ++ E L E E R++ +R+R + E+ + E Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407 Query: 1092 EDNDSDEAF-ESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRS 1150 D D F E ++ +++ D+ + EE+ R R+ + R ++R Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467 Query: 1151 PSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEEMMDSSTFKRF 1202 + E+ E RK ++E+Q +R+ + K +E+ ++F Sbjct: 1468 QLLQEREEQQ--LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKF 1517 Score = 57.0 bits (136), Expect = 2e-07 Identities = 136/898 (15%), Positives = 342/898 (38%), Gaps = 68/898 (7%) Query: 324 KKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTKLTLRLSRVRSSDMD--QQEDMISGVE 381 ++Q++ +L +E++Q E+ + P ++ + R R R ++ ++E+ + E Sbjct: 791 REQRERQLRAEERQQREQRFL------PEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844 Query: 382 NSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFL-PANQVPVLQQN 440 + + + +Q + ++ +D + ++ T + PA Q + ++ Sbjct: 845 RAQQLQEEED-GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903 Query: 441 TSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQ-DKD 499 + ++ + + +++ Q+ E E E++ RE +R R +E Q KD Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963 Query: 500 KPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPALMVSIDLHQAGRVDSQASITQ 559 K L+++++ G P + R + + Q R + + Q Sbjct: 964 KKLQQKEEQLL---------GEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014 Query: 560 DSD-SIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSES 618 + + +K +E++Q + +L+E E +++ + E++Q E Sbjct: 1015 EWERQYRKKDELQQEEE---QLLRE----------EREKRRLQERERQYREEEELQQEEE 1061 Query: 619 RLAESKPNENRLVETKSSENKLETKVETQTEEL-------KQNESRTTECKQNESTIVEP 671 +L + R E + K E +++ + E+L ++ + R +C++ E E Sbjct: 1062 QLLGEERETRRRQELERQYRK-EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEE 1120 Query: 672 KQ--NENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKG 729 +Q E R + +Q E + + +++ E R ++ E +Q+ Sbjct: 1121 EQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEE 1180 Query: 730 DG--RPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTK 787 + R E K++ E R +++ E + + K R+ + + +PE +D K Sbjct: 1181 EQLLREEQEKRRQE-RERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239 Query: 788 -----SDSPRLKSERAEALKQRPDGRSVSESL--RRDHDNKQKSDDRGESERHRGDQSRV 840 ++ + + L+ R + + L +++ D +Q+ + +RH ++ ++ Sbjct: 1240 VYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQL 1299 Query: 841 RRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGDS 900 R E + R+ + ++ E K R + D + R + R + P +Q Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD 1359 Query: 901 NKSRSDKLGFKSPTSK---DDKRTEGNKSKVDTNKAHPDNKA-EFPSYLLGGRSGALKNF 956 K R ++L + K +++R + + K + E L R + Sbjct: 1360 RKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREE 1419 Query: 957 VIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKL 1016 ++++D +E +++ + + +E+ + L + ++ L + ++ Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEE---EQQLRQERHRKFREEEQLLQEREEQ 1476 Query: 1017 IKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKR 1076 R+++ R L+ + + + L+ PE E +++ +R+R Sbjct: 1477 QLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE-----QQLHRQQRQR 1531 Query: 1077 STVNEKPKYA--EISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHS 1134 + E+ + E D D F + ++ +++ +ERDR+ + ++ Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591 Query: 1135 HEGRRSSGGGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLTPEE 1192 + R+ + R + + +++E+Q R+ + K EE Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEE 1649 Score = 38.9 bits (89), Expect = 0.069 Identities = 58/331 (17%), Positives = 136/331 (41%), Gaps = 27/331 (8%) Query: 594 ENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQ 653 E + +++ D + + E++ E + E +L + L+ + + + +E Q Sbjct: 1489 EEEQQLRRQERDRKFREQELRSQEPE-RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547 Query: 654 NESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPET 713 + + K E + ++ E +LS +Q R K R E K + R E Sbjct: 1548 QRRQDRDRKFREEEQLRQEREEQQLS-------RQERDR----KFRLEEQKVR---RQEQ 1593 Query: 714 PKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPST 773 ++ + + +Q+G + +Q+ + + +Q + R E HR + R Sbjct: 1594 ERKFMEDEQQLRRQEGQ---QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKF----L 1646 Query: 774 EKKPEVSKHK--QDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESE 831 E++P++ + + Q + D R E + L++ + + + R +++ R E E Sbjct: 1647 EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE 1706 Query: 832 RHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHES--GDSRERPSSGEQKSR 889 R + + R + L R E ++ ++ + ++L R+ R+ + + RP EQ+ R Sbjct: 1707 RKFLQEEQQLRRQELERKFREEEQLRQETEQ-EQLRRQERYRKILEEEQLRPEREEQQLR 1765 Query: 890 PDSPRVKQGDSNKSRSDKLGFKSPTSKDDKR 920 K + + R ++ + + + D++ Sbjct: 1766 RQERDRKFREEEQLRQEREEQQLRSQESDRK 1796 >gi|150170670 piccolo isoform 2 [Homo sapiens] Length = 4935 Score = 71.6 bits (174), Expect = 1e-11 Identities = 264/1350 (19%), Positives = 490/1350 (36%), Gaps = 232/1350 (17%) Query: 143 QQTTISHSPSSRFV-PPQTSSGNRFMPQQNSPVPS-----PYA---PQSPAGYMPYSH-- 191 +Q T+ SPS++ PP+ S ++ P + VPS P A P+ P P + Sbjct: 708 KQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLV 767 Query: 192 -PSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHM 250 SS TT P + + V S + K + PL +SA P G Sbjct: 768 SSSSATTKPDIPSSKVQSQA---------EEKTTPPLKTDSAKPSQSFPPTGEKVSPFDS 818 Query: 251 VHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDV 310 + DS + + Q P + PK ++ + + + P Sbjct: 819 -KAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPT 877 Query: 311 PPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMY--DIISSPSKDSTK----LTLRLSR 364 PP + + Q+ K +EQS + ++ I +P T +T +L Sbjct: 878 PPGPRPTAGQTVPTPQQSPK----PQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFG 933 Query: 365 VRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQE 424 +S Q ++IS P + PG K P ++P + Sbjct: 934 FGASIFSQASNLISTAGQPG------PHSQSGPGAPMKQAPAP---SQPPTSQGPPKSTG 984 Query: 425 QTAFLPANQVPVLQQNTSVAA-----KQPQTSVVQNQQQISQQGPIYDEVELDALAEIER 479 Q PA +PV ++ + AA K Q V+ + + PI D L A Sbjct: 985 QAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTA------ 1038 Query: 480 IERESAIERERFSKEVQDKDK-PLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPA 538 E + A+ + K + + PL K + + ++ +Q G P Sbjct: 1039 -EPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPH 1097 Query: 539 LMVSIDLHQAGRVDSQASITQDSDSIKK----------------PEEIKQCNDAPVSVL- 581 L I +Q +I+ I+K E Q P V Sbjct: 1098 L-TEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKL 1156 Query: 582 -----QEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSS 636 QE + K E ET + P + ++ KQ ES+L + K + + + Sbjct: 1157 VKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPE 1216 Query: 637 ENKL---ETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRS 693 E KL E K+ ++ ++ E + T E K+ + P + K Sbjct: 1217 EKKLIPEEEKIRSEEKKPLLEEKKPTP---------EDKKLLPEAKTSAPEEQKH----- 1262 Query: 694 ETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPE-TPKQKGESRPETPKQKNE 752 + KS+ + ++K E R PK +G + P+ K +G P TP+ + +T K E Sbjct: 1263 DLLKSQVQIAEEKLEGRV-APKTVQEG--KQPQTKMEGLPSGTPQSLPKEDDKTTKTIKE 1319 Query: 753 GRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSER-------AEALKQRP 805 +P+ P ++ + GK TEK+ + S + SP+ S+ + +L + P Sbjct: 1320 -QPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIP 1378 Query: 806 -----DGRSVSESLRRDHDNKQKS--------------------------DDRGE--SER 832 D + + + L++D +++ S D++ E ++ Sbjct: 1379 SLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQP 1438 Query: 833 HRGDQSRVRRPETLRSSSRN-EHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD 891 H + + E +S S E I + K + ERK + ++ PSS + K + + Sbjct: 1439 HEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSE 1498 Query: 892 -----SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLL 946 + R + DS + S+ SP + +RT S D K Sbjct: 1499 FVDDITTRREPYDSVEESSE--SENSPVPQRKRRTSVGSSSSDEYKQEDSQ--------- 1547 Query: 947 GGRSGALKNFV---IPKIKRDKDGN-------VTQETKKMEMKGEPKDKVEKIGLVEDLN 996 SG ++F+ I ++ D+D + + + K++ E + K E G + Sbjct: 1548 --GSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITA 1605 Query: 997 KGAKPVVVLQKLSLDD---VQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLK---E 1050 + + S+D+ + D +D++ +K + +KS + ++ V+ Sbjct: 1606 GKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQES--EELVVTGGGG 1663 Query: 1051 LPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEA-FESSRKRHKK 1109 L E+ ST+ + +++K S ++ E+ S D+ D + E S H Sbjct: 1664 LRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHAS 1723 Query: 1110 D-----DDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPS 1164 + + D SS H++ G S + R++ R+R P +ED S Sbjct: 1724 SFTPGTSPTSVSSLDEDSDSSPSHKK-GESKQQRKA----RHRPHGPLLPTIEDSSEEEE 1778 Query: 1165 LSEVARKMKKKEKQKKRKAYEPKLTPEEM---MDSSTFKRFTASIENILDNLEDMDFTAF 1221 L E +K++EKQ++ + + K + ++ D +R + NL + Sbjct: 1779 LREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPI----- 1833 Query: 1222 GDDDEIPQELLLGKHQLNELGSESAKIKAMGIMD-----KLSTDKTVKVLNILEKNIQDG 1276 +D P E L ++ EL S + I ++S +K ++V + Sbjct: 1834 --EDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVY------- 1884 Query: 1277 SKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERV 1336 KL T ++ + T+E+ + ++ ++ KSA+ E+++ + Sbjct: 1885 -KLPTAVSLYSPTDEQSIMQKE-GSQKALKSAEE-----------------MYEEMMHKT 1925 Query: 1337 IQYTKFHLQNTLYPQYDPVYRLDPHGGGLL 1366 +Y F N + D V+ +P GG+L Sbjct: 1926 HKYKAFPAAN----ERDEVFEKEPLYGGML 1951 Score = 45.8 bits (107), Expect = 6e-04 Identities = 153/746 (20%), Positives = 246/746 (32%), Gaps = 102/746 (13%) Query: 285 EGTPKGS-RPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAA 343 +G P+G +PPL Q P P+ P P ++ K + + EK +S+ Sbjct: 200 QGKPEGIIKPPL---QQQPPKPIPKQQGPG---RDPLQQDGTPKSISSQQPEKIKSQPPG 253 Query: 344 MYDIISSPSK----DSTKLTLRLSRVRSSDMDQQEDMISG--VENSNVSENDIPFN---- 393 I P++ D KL L+ R S +Q D++ G V+ S S + P Sbjct: 254 TGKPIQGPTQTPQTDHAKLPLQ--RDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTP 311 Query: 394 ----VQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQ 449 Q PG P + +P + L+QQ T + PV T+ QP Sbjct: 312 GKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTV-----KPPVQPPGTTKPPAQPL 366 Query: 450 TSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQD--KDKPLKKRKQ 507 QQ + P ++ ALA+ + + A + Q KPL ++ Sbjct: 367 GPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPG 426 Query: 508 DSYPQEAGGAT-----------------GGNRPASQETGSTGNGSRPALMVSIDLHQAG- 549 P +A G T G + ++Q+TG T S+ Q G Sbjct: 427 LQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGP 486 Query: 550 ------RVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKK 603 + S +Q S K P + Q A S Q GS K + Sbjct: 487 AKPPPQQPGSAKPPSQQPGSTKPPPQ--QPGPAKPSPQQP---GSTKPPSQQPGSAKPSA 541 Query: 604 SDPELSKSEMKQSE---SRLAESKPNENRLVETKSSENKLETKVET-----QTEEL---- 651 P +K +QS S+ KP + V + + + +T T EL Sbjct: 542 QQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHV 601 Query: 652 --KQNESRTTECKQNESTIV--EPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKG 707 K N + TEC+ ++ P + + + + + P +P+ K Sbjct: 602 PEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKL 661 Query: 708 ESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKN-------EGRPETPKH 760 ++ P T P+Q + PKQ PE K G P Sbjct: 662 KTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAK 721 Query: 761 RHDNRRDSGKPSTEKKPEV--SKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDH 818 + KP+ K+P V + K D P+ + + +K D S S + + Sbjct: 722 QPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPK----QPKMVKPTTDLVSSSSATTKPD 777 Query: 819 DNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSR 878 K + E + ++ +P S S G K + + R S Sbjct: 778 IPSSKVQSQAEEKTTPPLKTDSAKP----SQSFPPTGEKVSPFDSKAIPRPASDSKIISH 833 Query: 879 ERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFK---------SPTSKDDKRTEGNKSKVD 929 PSS E K + V++ + K K+ K SPT + T G Sbjct: 834 PGPSS-ESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTP 892 Query: 930 TNKAHPDNKAEFPSYLLGGRSGALKN 955 P ++ S LG + A K+ Sbjct: 893 QQSPKPQEQSRRFSLNLGSITDAPKS 918 Score = 41.2 bits (95), Expect = 0.014 Identities = 100/530 (18%), Positives = 188/530 (35%), Gaps = 71/530 (13%) Query: 284 SEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAA 343 ++G PKGS PP +S S+ LDS ++ + G+ + K+ Sbjct: 63 AQGLPKGSVPPAAAESPSMHRKQE--------LDSSHPPKQSGRPPDPGRPAQPGLSKSR 114 Query: 344 MYDIISS----PSKDSTKLTLRLSRVRSSDMDQQED-MISGVEN--------SNVSENDI 390 D S P + + ++L+ S+ R+ ++ + M+ G + S+V Sbjct: 115 TTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFN 174 Query: 391 PFNVQYPGQ------TSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVP---VLQQN- 440 PF++ + T K + ++ +P + QQ+ +P Q P LQQ+ Sbjct: 175 PFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDG 234 Query: 441 --TSVAAKQPQTSVVQ-----NQQQISQQGPIYDEVELDALAEIERIERESA--IERERF 491 S++++QP+ Q Q Q P D +L + R + + A + E Sbjct: 235 TPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESV 294 Query: 492 SKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQ---ETGSTGNGSRPALMVSIDLHQA 548 + KP ++ T G PA Q E G PA + A Sbjct: 295 KPSLPSPSKPPIQQP-----------TPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLA 343 Query: 549 GRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPEL 608 + + Q + K P + P + S + P+ + P P Sbjct: 344 QQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQ 403 Query: 609 SKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTI 668 K ++ KP L + ++ + T+T + + + Sbjct: 404 QPGPAKPPTQQVGTPKP----LAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPG-- 457 Query: 669 VEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETP--KQKGESRPETPKQKSDGHPETPK 726 K + + TKP + + P P +Q G ++P P Q+ P+ Sbjct: 458 ---KTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKP--PSQQPGSTKPPPQ 512 Query: 727 QKGDGRPETPKQKGESRPETPKQKNEGRP--ETPKHRHDNRRDSGKPSTE 774 Q G +P +P+Q G ++P + +Q +P + P + + S KP ++ Sbjct: 513 QPGPAKP-SPQQPGSTKPPS-QQPGSAKPSAQQPSPAKPSAQQSTKPVSQ 560 Score = 35.4 bits (80), Expect = 0.77 Identities = 41/195 (21%), Positives = 80/195 (41%), Gaps = 20/195 (10%) Query: 28 LPSPLPATTTKSLLFNARIAEEVNCLLACRDDNL-----VSQLVHSLNQVSTDHIELKDN 82 LP+P P + V+ CR + + + + L+ V + +L+ Sbjct: 3724 LPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKILQDIDRELDLVERESAKLRKK 3783 Query: 83 LGS-DDPEGDIPVLLQ----AVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSP 137 D+ E +I L+ + R + +E+ + R G+ + +S + + S+ Sbjct: 3784 QAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTR 3843 Query: 138 ASSNYQQ------TTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYSH 191 + Q T + S+F+PPQT + ++ +P SP + Y SPA +P Sbjct: 3844 PTRIESQHGIERPRTAPQTEFSQFIPPQTQTESQLVP-PTSPY-TQYQYSSPA--LPTQA 3899 Query: 192 PSSYTTHPQMQQASV 206 P+SYT +Q ++ Sbjct: 3900 PTSYTQQSHFEQQTL 3914 >gi|150378539 piccolo isoform 1 [Homo sapiens] Length = 5142 Score = 71.6 bits (174), Expect = 1e-11 Identities = 264/1350 (19%), Positives = 490/1350 (36%), Gaps = 232/1350 (17%) Query: 143 QQTTISHSPSSRFV-PPQTSSGNRFMPQQNSPVPS-----PYA---PQSPAGYMPYSH-- 191 +Q T+ SPS++ PP+ S ++ P + VPS P A P+ P P + Sbjct: 708 KQPTLHGSPSAKAKQPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPKQPKMVKPTTDLV 767 Query: 192 -PSSYTTHPQMQQASVSSPIVAGGLRNIHDNKVSGPLSGNSANHHADNPRHGSSEDYLHM 250 SS TT P + + V S + K + PL +SA P G Sbjct: 768 SSSSATTKPDIPSSKVQSQA---------EEKTTPPLKTDSAKPSQSFPPTGEKVSPFDS 818 Query: 251 VHRLSSDDGDSSTMRNAASFPLRSPQPVCSPAGSEGTPKGSRPPLILQSQSLPCSSPRDV 310 + DS + + Q P + PK ++ + + + P Sbjct: 819 -KAIPRPASDSKIISHPGPSSESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPT 877 Query: 311 PPDILLDSPERKQKKQKKMKLGKDEKEQSEKAAMY--DIISSPSKDSTK----LTLRLSR 364 PP + + Q+ K +EQS + ++ I +P T +T +L Sbjct: 878 PPGPRPTAGQTVPTPQQSPK----PQEQSRRFSLNLGSITDAPKSQPTTPQETVTGKLFG 933 Query: 365 VRSSDMDQQEDMISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQE 424 +S Q ++IS P + PG K P ++P + Sbjct: 934 FGASIFSQASNLISTAGQPG------PHSQSGPGAPMKQAPAP---SQPPTSQGPPKSTG 984 Query: 425 QTAFLPANQVPVLQQNTSVAA-----KQPQTSVVQNQQQISQQGPIYDEVELDALAEIER 479 Q PA +PV ++ + AA K Q V+ + + PI D L A Sbjct: 985 QAPPAPAKSIPVKKETKAPAAEKLEPKAEQAPTVKRTETEKKPPPIKDSKSLTA------ 1038 Query: 480 IERESAIERERFSKEVQDKDK-PLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPA 538 E + A+ + K + + PL K + + ++ +Q G P Sbjct: 1039 -EPQKAVLPTKLEKSPKPESTCPLCKTELNIGSKDPPNFNTCTECKNQVCNLCGFNPTPH 1097 Query: 539 LMVSIDLHQAGRVDSQASITQDSDSIKK----------------PEEIKQCNDAPVSVL- 581 L I +Q +I+ I+K E Q P V Sbjct: 1098 L-TEIQEWLCLNCQTQRAISGQLGDIRKMPPAPSGPKASPMPVPTESSSQKTAVPPQVKL 1156 Query: 582 -----QEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSS 636 QE + K E ET + P + ++ KQ ES+L + K + + + Sbjct: 1157 VKKQEQEVKTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKASALQEKKPLPE 1216 Query: 637 ENKL---ETKVETQTEELKQNESRTTECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRS 693 E KL E K+ ++ ++ E + T E K+ + P + K Sbjct: 1217 EKKLIPEEEKIRSEEKKPLLEEKKPTP---------EDKKLLPEAKTSAPEEQKH----- 1262 Query: 694 ETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPE-TPKQKGESRPETPKQKNE 752 + KS+ + ++K E R PK +G + P+ K +G P TP+ + +T K E Sbjct: 1263 DLLKSQVQIAEEKLEGRV-APKTVQEG--KQPQTKMEGLPSGTPQSLPKEDDKTTKTIKE 1319 Query: 753 GRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSER-------AEALKQRP 805 +P+ P ++ + GK TEK+ + S + SP+ S+ + +L + P Sbjct: 1320 -QPQPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIP 1378 Query: 806 -----DGRSVSESLRRDHDNKQKS--------------------------DDRGE--SER 832 D + + + L++D +++ S D++ E ++ Sbjct: 1379 SLIPTDEKDILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQP 1438 Query: 833 HRGDQSRVRRPETLRSSSRN-EHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD 891 H + + E +S S E I + K + ERK + ++ PSS + K + + Sbjct: 1439 HEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPSSKDHKEKSE 1498 Query: 892 -----SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNKAEFPSYLL 946 + R + DS + S+ SP + +RT S D K Sbjct: 1499 FVDDITTRREPYDSVEESSE--SENSPVPQRKRRTSVGSSSSDEYKQEDSQ--------- 1547 Query: 947 GGRSGALKNFV---IPKIKRDKDGN-------VTQETKKMEMKGEPKDKVEKIGLVEDLN 996 SG ++F+ I ++ D+D + + + K++ E + K E G + Sbjct: 1548 --GSGEEEDFIRKQIIEMSADEDASGSEDDEFIRNQLKEISSSTESQKKEETKGKGKITA 1605 Query: 997 KGAKPVVVLQKLSLDD---VQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLK---E 1050 + + S+D+ + D +D++ +K + +KS + ++ V+ Sbjct: 1606 GKHRRLTRKSSTSIDEDAGRRHSWHDEDDEAFDESPELKYRETKSQES--EELVVTGGGG 1663 Query: 1051 LPPELLAEIESTMPLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEA-FESSRKRHKK 1109 L E+ ST+ + +++K S ++ E+ S D+ D + E S H Sbjct: 1664 LRRFKTIELNSTIADKYSAESSQKKTSLYFDEEPELEMESLTDSPEDRSRGEGSSSLHAS 1723 Query: 1110 D-----DDKAWEYEERDRRSSGDHRRSGHSHEGRRSSGGGRYRNRSPSDSDMEDYSPPPS 1164 + + D SS H++ G S + R++ R+R P +ED S Sbjct: 1724 SFTPGTSPTSVSSLDEDSDSSPSHKK-GESKQQRKA----RHRPHGPLLPTIEDSSEEEE 1778 Query: 1165 LSEVARKMKKKEKQKKRKAYEPKLTPEEM---MDSSTFKRFTASIENILDNLEDMDFTAF 1221 L E +K++EKQ++ + + K + ++ D +R + NL + Sbjct: 1779 LREEEELLKEQEKQREIEQQQRKSSSKKSKKDKDELRAQRRRERPKTPPSNLSPI----- 1833 Query: 1222 GDDDEIPQELLLGKHQLNELGSESAKIKAMGIMD-----KLSTDKTVKVLNILEKNIQDG 1276 +D P E L ++ EL S + I ++S +K ++V + Sbjct: 1834 --EDASPTEELRQAAEMEELHRSSCSEYSPSIESDPEGFEISPEKIIEVQKVY------- 1884 Query: 1277 SKLSTLLNHNNDTEEEERLWRDLIMERVTKSADACLTTINIMTSPNMPKAVYIEDVIERV 1336 KL T ++ + T+E+ + ++ ++ KSA+ E+++ + Sbjct: 1885 -KLPTAVSLYSPTDEQSIMQKE-GSQKALKSAEE-----------------MYEEMMHKT 1925 Query: 1337 IQYTKFHLQNTLYPQYDPVYRLDPHGGGLL 1366 +Y F N + D V+ +P GG+L Sbjct: 1926 HKYKAFPAAN----ERDEVFEKEPLYGGML 1951 Score = 45.8 bits (107), Expect = 6e-04 Identities = 153/746 (20%), Positives = 246/746 (32%), Gaps = 102/746 (13%) Query: 285 EGTPKGS-RPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAA 343 +G P+G +PPL Q P P+ P P ++ K + + EK +S+ Sbjct: 200 QGKPEGIIKPPL---QQQPPKPIPKQQGPG---RDPLQQDGTPKSISSQQPEKIKSQPPG 253 Query: 344 MYDIISSPSK----DSTKLTLRLSRVRSSDMDQQEDMISG--VENSNVSENDIPFN---- 393 I P++ D KL L+ R S +Q D++ G V+ S S + P Sbjct: 254 TGKPIQGPTQTPQTDHAKLPLQ--RDASRPQTKQADIVRGESVKPSLPSPSKPPIQQPTP 311 Query: 394 ----VQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVPVLQQNTSVAAKQPQ 449 Q PG P + +P + L+QQ T + PV T+ QP Sbjct: 312 GKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTV-----KPPVQPPGTTKPPAQPL 366 Query: 450 TSVVQNQQQISQQGPIYDEVELDALAEIERIERESAIERERFSKEVQD--KDKPLKKRKQ 507 QQ + P ++ ALA+ + + A + Q KPL ++ Sbjct: 367 GPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGTPKPLAQQPG 426 Query: 508 DSYPQEAGGAT-----------------GGNRPASQETGSTGNGSRPALMVSIDLHQAG- 549 P +A G T G + ++Q+TG T S+ Q G Sbjct: 427 LQSPAKAPGPTKTPVQQPGPGKIPAQQAGPGKTSAQQTGPTKPPSQLPGPAKPPPQQPGP 486 Query: 550 ------RVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKK 603 + S +Q S K P + Q A S Q GS K + Sbjct: 487 AKPPPQQPGSAKPPSQQPGSTKPPPQ--QPGPAKPSPQQP---GSTKPPSQQPGSAKPSA 541 Query: 604 SDPELSKSEMKQSE---SRLAESKPNENRLVETKSSENKLETKVET-----QTEEL---- 651 P +K +QS S+ KP + V + + + +T T EL Sbjct: 542 QQPSPAKPSAQQSTKPVSQTGSGKPLQPPTVSPSAKQPPSQGLPKTICPLCNTTELLLHV 601 Query: 652 --KQNESRTTECKQNESTIV--EPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKG 707 K N + TEC+ ++ P + + + + + P +P+ K Sbjct: 602 PEKANFNTCTECQTTVCSLCGFNPNPHLTEVKEWLCLNCQMKRALGGDLAPVPSSPQPKL 661 Query: 708 ESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKN-------EGRPETPKH 760 ++ P T P+Q + PKQ PE K G P Sbjct: 662 KTAPVTTTSAVSKSSPQPQQTSPKKDAAPKQDLSKAPEPKKPPPLVKQPTLHGSPSAKAK 721 Query: 761 RHDNRRDSGKPSTEKKPEV--SKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDH 818 + KP+ K+P V + K D P+ + + +K D S S + + Sbjct: 722 QPPEADSLSKPAPPKEPSVPSEQDKAPVADDKPK----QPKMVKPTTDLVSSSSATTKPD 777 Query: 819 DNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSR 878 K + E + ++ +P S S G K + + R S Sbjct: 778 IPSSKVQSQAEEKTTPPLKTDSAKP----SQSFPPTGEKVSPFDSKAIPRPASDSKIISH 833 Query: 879 ERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFK---------SPTSKDDKRTEGNKSKVD 929 PSS E K + V++ + K K+ K SPT + T G Sbjct: 834 PGPSS-ESKGQKQVDPVQKKEEPKKAQTKMSPKPDAKPMPKGSPTPPGPRPTAGQTVPTP 892 Query: 930 TNKAHPDNKAEFPSYLLGGRSGALKN 955 P ++ S LG + A K+ Sbjct: 893 QQSPKPQEQSRRFSLNLGSITDAPKS 918 Score = 41.2 bits (95), Expect = 0.014 Identities = 100/530 (18%), Positives = 188/530 (35%), Gaps = 71/530 (13%) Query: 284 SEGTPKGSRPPLILQSQSLPCSSPRDVPPDILLDSPERKQKKQKKMKLGKDEKEQSEKAA 343 ++G PKGS PP +S S+ LDS ++ + G+ + K+ Sbjct: 63 AQGLPKGSVPPAAAESPSMHRKQE--------LDSSHPPKQSGRPPDPGRPAQPGLSKSR 114 Query: 344 MYDIISS----PSKDSTKLTLRLSRVRSSDMDQQED-MISGVEN--------SNVSENDI 390 D S P + + ++L+ S+ R+ ++ + M+ G + S+V Sbjct: 115 TTDTFRSEQKLPGRSPSTISLKESKSRTDLKEEHKSSMMPGFLSEVNALSAVSSVVNKFN 174 Query: 391 PFNVQYPGQ------TSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVP---VLQQN- 440 PF++ + T K + ++ +P + QQ+ +P Q P LQQ+ Sbjct: 175 PFDLISDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDG 234 Query: 441 --TSVAAKQPQTSVVQ-----NQQQISQQGPIYDEVELDALAEIERIERESA--IERERF 491 S++++QP+ Q Q Q P D +L + R + + A + E Sbjct: 235 TPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESV 294 Query: 492 SKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQ---ETGSTGNGSRPALMVSIDLHQA 548 + KP ++ T G PA Q E G PA + A Sbjct: 295 KPSLPSPSKPPIQQP-----------TPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLA 343 Query: 549 GRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPEL 608 + + Q + K P + P + S + P+ + P P Sbjct: 344 QQPGTVKPPVQPPGTTKPPAQPLGPAKPPAQQTGSEKPSSEQPGPKALAQPPGVGKTPAQ 403 Query: 609 SKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTI 668 K ++ KP L + ++ + T+T + + + Sbjct: 404 QPGPAKPPTQQVGTPKP----LAQQPGLQSPAKAPGPTKTPVQQPGPGKIPAQQAGPG-- 457 Query: 669 VEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETP--KQKGESRPETPKQKSDGHPETPK 726 K + + TKP + + P P +Q G ++P P Q+ P+ Sbjct: 458 ---KTSAQQTGPTKPPSQLPGPAKPPPQQPGPAKPPPQQPGSAKP--PSQQPGSTKPPPQ 512 Query: 727 QKGDGRPETPKQKGESRPETPKQKNEGRP--ETPKHRHDNRRDSGKPSTE 774 Q G +P +P+Q G ++P + +Q +P + P + + S KP ++ Sbjct: 513 QPGPAKP-SPQQPGSTKPPS-QQPGSAKPSAQQPSPAKPSAQQSTKPVSQ 560 Score = 35.4 bits (80), Expect = 0.77 Identities = 41/195 (21%), Positives = 80/195 (41%), Gaps = 20/195 (10%) Query: 28 LPSPLPATTTKSLLFNARIAEEVNCLLACRDDNL-----VSQLVHSLNQVSTDHIELKDN 82 LP+P P + V+ CR + + + + L+ V + +L+ Sbjct: 3724 LPNPPPEEISTGTQSTFSTMGTVSRRRICRTNTMARAKILQDIDRELDLVERESAKLRKK 3783 Query: 83 LGS-DDPEGDIPVLLQ----AVLARSPNVFREKSMQNRYVQSGMMMSQYKLSQNSMHSSP 137 D+ E +I L+ + R + +E+ + R G+ + +S + + S+ Sbjct: 3784 QAELDEEEKEIDAKLRYLEMGINRRKEALLKEREKRERAYLQGVAEDRDYMSDSEVSSTR 3843 Query: 138 ASSNYQQ------TTISHSPSSRFVPPQTSSGNRFMPQQNSPVPSPYAPQSPAGYMPYSH 191 + Q T + S+F+PPQT + ++ +P SP + Y SPA +P Sbjct: 3844 PTRIESQHGIERPRTAPQTEFSQFIPPQTQTESQLVP-PTSPY-TQYQYSSPA--LPTQA 3899 Query: 192 PSSYTTHPQMQQASV 206 P+SYT +Q ++ Sbjct: 3900 PTSYTQQSHFEQQTL 3914 >gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] Length = 2039 Score = 68.6 bits (166), Expect = 8e-11 Identities = 130/670 (19%), Positives = 256/670 (38%), Gaps = 88/670 (13%) Query: 567 PEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPN 626 P+ K P VL S + +N + PE S S+M+ + + + Sbjct: 385 PKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHK 444 Query: 627 ENRLVETK-SSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNE--NRLSDTKP 683 + V+ K ++NK + E + E+ + +R T N K E N P Sbjct: 445 QKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSP 504 Query: 684 NDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDG----RPETPK-- 737 D+ + +T P+ E + KQ+ H +T G +P+ + Sbjct: 505 KDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQE---HTKTCLSPGSSEMSLQPDLVRYD 561 Query: 738 -QKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSE 796 + E PE+ K+ E KH+ D + G+ S K + + SP ++ Sbjct: 562 NTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKD--------EDHSPTFENS 613 Query: 797 RAEALKQRPDGRSVSESLRRDHD---NKQKSDDRGESERHRGDQS--RVRRPETLRSSSR 851 K +G+++ + + + K K + GE E+++ S ++R Sbjct: 614 DCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFW 673 Query: 852 NEHGIKSDSS---------------KTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVK 896 E+ KSD + K KLE K+ + ++E+ S E+ + + ++K Sbjct: 674 KENFFKSDETEDLFLNMEHESLTLEKKSKLE-KNIKDDKSTKEKHVSKERNFKEERDKIK 732 Query: 897 QGDSNKSRSDKL------GFKSPTSKDDKRTEGNKSKVD-------TNKAHPDNKAEFPS 943 + R +K+ PT KD + T S ++ K K E Sbjct: 733 KESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE--K 790 Query: 944 YLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVV 1003 ++ + K I + +K T E K+ ++K E K + +K+ L E ++K + Sbjct: 791 HIKESKEKPEKRSQIKEKDIEKMERKTFE-KEKKIKHEHKSEKDKLDLSECVDK----IK 845 Query: 1004 VLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTM 1063 KL +K K+ E KS+++ K + ++ +D+ KE P Sbjct: 846 EKDKLYSHHTEKCHKEGE-KSKNTAAIKKTDDREKSREKMDRKHDKEKP----------- 893 Query: 1064 PLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRR 1123 +++R K K+ ++ +D+ E +S + ++K+ D + + E+ + Sbjct: 894 ---------EKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 944 Query: 1124 SSGDHRRSGHSHEGRRSS--GGGRYRNRSP---SDSDMEDYSPPPSLSEVARKMKKKEKQ 1178 S + S H E ++SS G + ++ P + ++ P E +K K ++ Sbjct: 945 ESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRY 1004 Query: 1179 KKRKAYEPKL 1188 K+R ++ K+ Sbjct: 1005 KERDKHKDKI 1014 Score = 68.2 bits (165), Expect = 1e-10 Identities = 111/562 (19%), Positives = 223/562 (39%), Gaps = 78/562 (13%) Query: 560 DSDSIKKPEEIKQCNDAPVSVLQEDI------VGSLKSTPENHPETPK------KKSDPE 607 +S+ + + +K C S Q+D + K E+H T + KK D E Sbjct: 564 ESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKE 623 Query: 608 ---LSKSEMKQSESRLAESKPN---ENRLVETKSSENKLETKVETQTEELKQNESRTTEC 661 L K ++K E + K E +TK S +L+ VE E K+N ++ E Sbjct: 624 GKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDET 683 Query: 662 K------QNESTIVEPKQN-ENRLSDTKPND----NKQNNGRSETTKSRPETPKQKGESR 710 + ++ES +E K E + D K +K+ N + E K + E+ K E + Sbjct: 684 EDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEK 743 Query: 711 PETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGK 770 + K++ + P + + ++ K+ + + E KH +++ K Sbjct: 744 IKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE--KHIKESKEKPEK 801 Query: 771 PSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGES 830 S K+ ++ K ++ T ++K E K D +SE + + + + E Sbjct: 802 RSQIKEKDIEKMERKTFEKEKKIKHEH----KSEKDKLDLSECVDKIKEKDKLYSHHTEK 857 Query: 831 ERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKT---DKLERKHRHESGDSRERPSSGEQK 887 G++S+ N IK + +K++RKH E + + ++K Sbjct: 858 CHKEGEKSK------------NTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 905 Query: 888 SRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEG-NKSKVD-TNKAHPDNKAEFPSYL 945 + + +S S+S+K K + DK+ + +K ++ TN H + E S + Sbjct: 906 HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKH--IQEEKKSSI 963 Query: 946 LGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMK---GEPKDKVEKIGLVEDLNKGAKPV 1002 + G K + +K ++ ++TK +K G+ KDK +K D+++ + Sbjct: 964 VDGN----------KAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK-----DIDRYKERD 1008 Query: 1003 VVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIEST 1062 K+ ++ + KL K DK + P K ++ +++ +L + Sbjct: 1009 KHKDKIQINSLLKL-KSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERML-----S 1062 Query: 1063 MPLCERVKMNKRKRSTVNEKPK 1084 + E + +K+ + + +K K Sbjct: 1063 LKDLEIEQWHKKHKEKIKQKEK 1084 Score = 52.0 bits (123), Expect = 8e-06 Identities = 67/345 (19%), Positives = 136/345 (39%), Gaps = 43/345 (12%) Query: 551 VDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSK 610 V + + ++ D IKK E +E+ + LK EN P T K L Sbjct: 718 VSKERNFKEERDKIKKESE---------KSFREEKIKDLKEERENIP-TDKDSEFTSLGM 767 Query: 611 SEMKQS---------------ESRLAESKPNENRLVETKSSE-NKLETKVETQTEELKQN 654 S +++S E + ESK + + K + K+E K + +++K + Sbjct: 768 SAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIK-H 826 Query: 655 ESRTTECKQNESTIVEPKQNENRLSDT------KPNDNKQNNGRSETTKSRPETPKQKGE 708 E ++ + K + S V+ + +++L K + +N + T R E ++K + Sbjct: 827 EHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR-EKSREKMD 885 Query: 709 SRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDS 768 + + K + + H K+K ++K + + K+E K R ++++ Sbjct: 886 RKHDKEKPEKERHLAESKEK-----HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEK 940 Query: 769 GKPSTEKKPEVSKHKQDTKS----DSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKS 824 + SKH Q+ K D + + E+ +LK++ + ++ D K K Sbjct: 941 SRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKD 1000 Query: 825 DDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERK 869 DR + D+ ++ L+S + S +SK + + K Sbjct: 1001 IDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEK 1045 Score = 40.0 bits (92), Expect = 0.031 Identities = 41/181 (22%), Positives = 71/181 (39%), Gaps = 8/181 (4%) Query: 665 ESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPET 724 +S +P Q+EN SD+ + + S +TPK + + K+KS + Sbjct: 3 KSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKL 62 Query: 725 PKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQ 784 P R E ++ ++ E P++K + K G P +E+K + Sbjct: 63 PFTISPSRNE--ERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQM 120 Query: 785 DTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERH----RGDQSRV 840 + +SP S + P + S R D K ++RGE+ H RGD +V Sbjct: 121 TARDNSP--DSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERGETPLHMAAIRGDVKQV 178 Query: 841 R 841 + Sbjct: 179 K 179 Score = 37.7 bits (86), Expect = 0.15 Identities = 44/172 (25%), Positives = 69/172 (40%), Gaps = 22/172 (12%) Query: 610 KSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQ--TEELKQNESRTTECKQNEST 667 +SE S+S + E KP + + +S +K K+E ++E+K+ S K+ Sbjct: 11 QSENSDSDSNMVE-KPYGRKSKDKIASYSKTP-KIERSDVSKEMKEKSSM----KRKLPF 64 Query: 668 IVEPKQNENRLSDTKPN--DNKQNNGRSETTKSRP---------ETPKQKGESRPETPKQ 716 + P +NE R SDT+ + K+ + KS P KQ T + Sbjct: 65 TISPSRNEERDSDTEKEGPEKKKTKKEAGNKKSTPVSILFGYPLSERKQMALLMQMTARD 124 Query: 717 KS-DGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRD 767 S D P P Q + +TP + + K+ G ETP H R D Sbjct: 125 NSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNERG--ETPLHMAAIRGD 174 Score = 33.1 bits (74), Expect = 3.8 Identities = 25/80 (31%), Positives = 41/80 (51%), Gaps = 8/80 (10%) Query: 2443 QEEPLFI-MHHIDITLSVSGS---NLL--QSFKESMVKDKR--KERKSSPSKENESSDSE 2494 + E LF+ M H +TL N+ +S KE V +R KE + KE+E S E Sbjct: 682 ETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFRE 741 Query: 2495 EEVSRPRKSRKRVDSDSDSD 2514 E++ ++ R+ + +D DS+ Sbjct: 742 EKIKDLKEERENIPTDKDSE 761 >gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] Length = 2062 Score = 68.6 bits (166), Expect = 8e-11 Identities = 130/670 (19%), Positives = 256/670 (38%), Gaps = 88/670 (13%) Query: 567 PEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPN 626 P+ K P VL S + +N + PE S S+M+ + + + Sbjct: 408 PKSFKSKKQKPSRVLYSSTESSDEEALQNKKISTSCSVIPETSNSDMQTKKEYVVSGEHK 467 Query: 627 ENRLVETK-SSENKLETKVETQTEELKQNESRTTECKQNESTIVEPKQNE--NRLSDTKP 683 + V+ K ++NK + E + E+ + +R T N K E N P Sbjct: 468 QKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSEKTREEGNFRKSFSP 527 Query: 684 NDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDG----RPETPK-- 737 D+ + +T P+ E + KQ+ H +T G +P+ + Sbjct: 528 KDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQE---HTKTCLSPGSSEMSLQPDLVRYD 584 Query: 738 -QKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSE 796 + E PE+ K+ E KH+ D + G+ S K + + SP ++ Sbjct: 585 NTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKD--------EDHSPTFENS 636 Query: 797 RAEALKQRPDGRSVSESLRRDHD---NKQKSDDRGESERHRGDQS--RVRRPETLRSSSR 851 K +G+++ + + + K K + GE E+++ S ++R Sbjct: 637 DCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFW 696 Query: 852 NEHGIKSDSS---------------KTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVK 896 E+ KSD + K KLE K+ + ++E+ S E+ + + ++K Sbjct: 697 KENFFKSDETEDLFLNMEHESLTLEKKSKLE-KNIKDDKSTKEKHVSKERNFKEERDKIK 755 Query: 897 QGDSNKSRSDKL------GFKSPTSKDDKRTEGNKSKVD-------TNKAHPDNKAEFPS 943 + R +K+ PT KD + T S ++ K K E Sbjct: 756 KESEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE--K 813 Query: 944 YLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMKGEPKDKVEKIGLVEDLNKGAKPVV 1003 ++ + K I + +K T E K+ ++K E K + +K+ L E ++K + Sbjct: 814 HIKESKEKPEKRSQIKEKDIEKMERKTFE-KEKKIKHEHKSEKDKLDLSECVDK----IK 868 Query: 1004 VLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIESTM 1063 KL +K K+ E KS+++ K + ++ +D+ KE P Sbjct: 869 EKDKLYSHHTEKCHKEGE-KSKNTAAIKKTDDREKSREKMDRKHDKEKP----------- 916 Query: 1064 PLCERVKMNKRKRSTVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRR 1123 +++R K K+ ++ +D+ E +S + ++K+ D + + E+ + Sbjct: 917 ---------EKERHLAESKEKHLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDK 967 Query: 1124 SSGDHRRSGHSHEGRRSS--GGGRYRNRSP---SDSDMEDYSPPPSLSEVARKMKKKEKQ 1178 S + S H E ++SS G + ++ P + ++ P E +K K ++ Sbjct: 968 ESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKDIDRY 1027 Query: 1179 KKRKAYEPKL 1188 K+R ++ K+ Sbjct: 1028 KERDKHKDKI 1037 Score = 68.2 bits (165), Expect = 1e-10 Identities = 111/562 (19%), Positives = 223/562 (39%), Gaps = 78/562 (13%) Query: 560 DSDSIKKPEEIKQCNDAPVSVLQEDI------VGSLKSTPENHPETPK------KKSDPE 607 +S+ + + +K C S Q+D + K E+H T + KK D E Sbjct: 587 ESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKMDKE 646 Query: 608 ---LSKSEMKQSESRLAESKPN---ENRLVETKSSENKLETKVETQTEELKQNESRTTEC 661 L K ++K E + K E +TK S +L+ VE E K+N ++ E Sbjct: 647 GKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRSVEFDREFWKENFFKSDET 706 Query: 662 K------QNESTIVEPKQN-ENRLSDTKPND----NKQNNGRSETTKSRPETPKQKGESR 710 + ++ES +E K E + D K +K+ N + E K + E+ K E + Sbjct: 707 EDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEK 766 Query: 711 PETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGK 770 + K++ + P + + ++ K+ + + E KH +++ K Sbjct: 767 IKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQE--KHIKESKEKPEK 824 Query: 771 PSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGES 830 S K+ ++ K ++ T ++K E K D +SE + + + + E Sbjct: 825 RSQIKEKDIEKMERKTFEKEKKIKHEH----KSEKDKLDLSECVDKIKEKDKLYSHHTEK 880 Query: 831 ERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKT---DKLERKHRHESGDSRERPSSGEQK 887 G++S+ N IK + +K++RKH E + + ++K Sbjct: 881 CHKEGEKSK------------NTAAIKKTDDREKSREKMDRKHDKEKPEKERHLAESKEK 928 Query: 888 SRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEG-NKSKVD-TNKAHPDNKAEFPSYL 945 + + +S S+S+K K + DK+ + +K ++ TN H + E S + Sbjct: 929 HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKH--IQEEKKSSI 986 Query: 946 LGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMK---GEPKDKVEKIGLVEDLNKGAKPV 1002 + G K + +K ++ ++TK +K G+ KDK +K D+++ + Sbjct: 987 VDGN----------KAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDK-----DIDRYKERD 1031 Query: 1003 VVLQKLSLDDVQKLIKDREDKSRSSLKPIKNKPSKSNKGSIDQSVLKELPPELLAEIEST 1062 K+ ++ + KL K DK + P K ++ +++ +L + Sbjct: 1032 KHKDKIQINSLLKL-KSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTSFERML-----S 1085 Query: 1063 MPLCERVKMNKRKRSTVNEKPK 1084 + E + +K+ + + +K K Sbjct: 1086 LKDLEIEQWHKKHKEKIKQKEK 1107 Score = 52.0 bits (123), Expect = 8e-06 Identities = 67/345 (19%), Positives = 136/345 (39%), Gaps = 43/345 (12%) Query: 551 VDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSK 610 V + + ++ D IKK E +E+ + LK EN P T K L Sbjct: 741 VSKERNFKEERDKIKKESE---------KSFREEKIKDLKEERENIP-TDKDSEFTSLGM 790 Query: 611 SEMKQS---------------ESRLAESKPNENRLVETKSSE-NKLETKVETQTEELKQN 654 S +++S E + ESK + + K + K+E K + +++K + Sbjct: 791 SAIEESIGLHLVEKEIDIEKQEKHIKESKEKPEKRSQIKEKDIEKMERKTFEKEKKIK-H 849 Query: 655 ESRTTECKQNESTIVEPKQNENRLSDT------KPNDNKQNNGRSETTKSRPETPKQKGE 708 E ++ + K + S V+ + +++L K + +N + T R E ++K + Sbjct: 850 EHKSEKDKLDLSECVDKIKEKDKLYSHHTEKCHKEGEKSKNTAAIKKTDDR-EKSREKMD 908 Query: 709 SRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDS 768 + + K + + H K+K ++K + + K+E K R ++++ Sbjct: 909 RKHDKEKPEKERHLAESKEK-----HLMEKKNKQSDNSEYSKSEKGKNKEKDRELDKKEK 963 Query: 769 GKPSTEKKPEVSKHKQDTKS----DSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKS 824 + SKH Q+ K D + + E+ +LK++ + ++ D K K Sbjct: 964 SRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKDEPLKTPDGKEKDKKDKD 1023 Query: 825 DDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERK 869 DR + D+ ++ L+S + S +SK + + K Sbjct: 1024 IDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEK 1068 Score = 38.5 bits (88), Expect = 0.090 Identities = 50/193 (25%), Positives = 78/193 (40%), Gaps = 41/193 (21%) Query: 610 KSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQ--TEELKQNESRTTECKQNEST 667 +SE S+S + E KP + + +S +K K+E ++E+K+ S K+ Sbjct: 11 QSENSDSDSNMVE-KPYGRKSKDKIASYSKTP-KIERSDVSKEMKEKSSM----KRKLPF 64 Query: 668 IVEPKQNENRLSDT--KPNDNKQNNG-------RSETTKSRPETPKQKGE--SRPETPKQ 716 + P +NE R SDT P +N G R+ + K PE K K E ++ TP Sbjct: 65 TISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTPVS 124 Query: 717 KSDGHPETPKQK-------------GDGRPETPKQKGESRPETPK---------QKNEGR 754 G+P + +++ D P P Q ++ +TP K R Sbjct: 125 ILFGYPLSERKQMALLMQMTARDNSPDSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNER 184 Query: 755 PETPKHRHDNRRD 767 ETP H R D Sbjct: 185 GETPLHMAAIRGD 197 Score = 35.8 bits (81), Expect = 0.59 Identities = 43/202 (21%), Positives = 72/202 (35%), Gaps = 27/202 (13%) Query: 665 ESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESRPETPKQKSDGHPET 724 +S +P Q+EN SD+ + + S +TPK + + K+KS + Sbjct: 3 KSGFTKPIQSENSDSDSNMVEKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKL 62 Query: 725 PKQKGDGRPETPKQKGESRP---------------ETPKQKNEGRPETPKHRHDNRRDS- 768 P R E +S P T +K + K N++ + Sbjct: 63 PFTISPSRNEERDSDTDSDPGHTSENWGERLISSYRTYSEKEGPEKKKTKKEAGNKKSTP 122 Query: 769 -----GKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQK 823 G P +E+K + + +SP S + P + S R D K Sbjct: 123 VSILFGYPLSERKQMALLMQMTARDNSP--DSTPNHPSQTTPAQKKTPSSSSRQKDKVNK 180 Query: 824 SDDRGESERH----RGDQSRVR 841 ++RGE+ H RGD +V+ Sbjct: 181 RNERGETPLHMAAIRGDVKQVK 202 Score = 33.1 bits (74), Expect = 3.8 Identities = 25/80 (31%), Positives = 41/80 (51%), Gaps = 8/80 (10%) Query: 2443 QEEPLFI-MHHIDITLSVSGS---NLL--QSFKESMVKDKR--KERKSSPSKENESSDSE 2494 + E LF+ M H +TL N+ +S KE V +R KE + KE+E S E Sbjct: 705 ETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFRE 764 Query: 2495 EEVSRPRKSRKRVDSDSDSD 2514 E++ ++ R+ + +D DS+ Sbjct: 765 EKIKDLKEERENIPTDKDSE 784 >gi|117676384 splicing factor, arginine/serine-rich 2, interacting protein [Homo sapiens] Length = 1463 Score = 68.2 bits (165), Expect = 1e-10 Identities = 83/336 (24%), Positives = 133/336 (39%), Gaps = 55/336 (16%) Query: 621 AESKPNENRLVETKSSENKLETKVETQTEELKQNESRTTECKQNESTIVEPK-------- 672 +E+ +N L+ TK E LE K E+ TE + E T +Q + E Sbjct: 663 SENNLLKNNLLNTKL-EKSLEEKNESLTEHPRSTELPKTHIEQIQKHFSEDNNEMIPMEC 721 Query: 673 ------QNENRLSDTKPNDNKQNNGRSETTKSRPETPKQK-GESRPETPKQKSDGHPET- 724 QNE+ + + D KQ N S T S P + + ET Q S+ +T Sbjct: 722 DSFCSDQNESEVEPSVNADLKQMNENSVTHCSENNMPSSDLADEKVETVSQPSESPKDTI 781 Query: 725 -----PKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPSTEKKPEV 779 P+ + R +P +TP++K RP++P R R++GK S Sbjct: 782 DKTKKPRTRRS-RFHSPSTTWSPNKDTPQEKK--RPQSPSPR----RETGKESR------ 828 Query: 780 SKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESERHRGDQSR 839 KS SP K+E A K+ + R ++ +S R + R +S Sbjct: 829 -------KSQSPSPKNESARGRKKSRSQSPKKDIARERRQSQSRSPKRDTTRESRRSESL 881 Query: 840 VRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPDSPRVKQGD 899 R ET R + R++ +K DSS +K SRER S + + R R ++ Sbjct: 882 SPRRETSRENKRSQPRVK-DSSPGEK-------SRSQSRERESDRDGQRRERERRTRKWS 933 Query: 900 SNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHP 935 ++S S +SP+ K + ++D + P Sbjct: 934 RSRSHS-----RSPSRCRTKSKSSSFGRIDRDSYSP 964 Score = 57.4 bits (137), Expect = 2e-07 Identities = 84/395 (21%), Positives = 145/395 (36%), Gaps = 52/395 (13%) Query: 574 NDAPVSVLQEDIVGSLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVET 633 N+ P S L ++ V ++ E+ +T K P +S + + +K Sbjct: 755 NNMPSSDLADEKVETVSQPSESPKDTIDKTKKPRTRRSRFHSPSTTWSPNKDTPQEKKRP 814 Query: 634 KSSENKLETKVETQTEELK--QNESRTTECKQNESTIVEPKQNENRLSDTKP--NDNKQN 689 +S + ET E++ + +NES K + + E R S ++ D + Sbjct: 815 QSPSPRRETGKESRKSQSPSPKNESARGRKKSRSQSPKKDIARERRQSQSRSPKRDTTRE 874 Query: 690 NGRSETTKSRPETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQ 749 + RSE+ R ET ++ S+P K S G K + R + G+ R + Sbjct: 875 SRRSESLSPRRETSRENKRSQPRV-KDSSPGE----KSRSQSRERESDRDGQRRERERRT 929 Query: 750 KNEGRPETPKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSE---------RAEA 800 + R + R K S S + D S SPR K R Sbjct: 930 RKWSRSRSHSRSPSRCRTKSKSS-------SFGRIDRDSYSPRWKGRWANDGWRCPRGND 982 Query: 801 LKQRPDGRSVSESLRRD-HDNKQKSDDRGESERHRGD-------------QSRVRRPETL 846 ++ D +E+ R++ +D +DD +++HR D R R PE L Sbjct: 983 RYRKNDPEKQNENTRKEKNDIHLDADDPNSADKHRNDCPNWITEKINSGPDPRTRNPEKL 1042 Query: 847 RSS----SRNEHGIKSDSSKTDKLERKHRHESGDSRERPS-------SGEQKSRPDSPRV 895 + S +RNE+ S + +R +R R + + ++R + + Sbjct: 1043 KESHWEENRNENSGNSWNKNFGSGWVSNRGRGRGNRGRGTYRSSFAYKDQNENRWQNRKP 1102 Query: 896 KQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDT 930 G+SN S S+ FK + KR + DT Sbjct: 1103 LSGNSNSSGSE--SFKFVEQQSYKRKSEQEFSFDT 1135 Score = 54.7 bits (130), Expect = 1e-06 Identities = 80/407 (19%), Positives = 154/407 (37%), Gaps = 32/407 (7%) Query: 553 SQASITQDSDSIKKPEEIKQCNDAPVSVLQ-------------EDIVGSLKSTPENHPET 599 SQ+ + D ++ P + C + V Q E +V K T + E Sbjct: 533 SQSEVKTDVCTVHLPNDFPTCLTSESKVYQPVSCPLSDLSENVESVVNEEKITESSLVEI 592 Query: 600 PKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVE----TQTEELKQNE 655 + K D L E+ +S + + +E +++T ++ +V+ +TE+++ Sbjct: 593 TEHK-DFTLKTEELIESP----KLESSEGEIIQTVDRQSVKSPEVQLLGHVETEDVEIIA 647 Query: 656 SRTTECKQNESTIVEPKQN--ENRLSDTKPNDNKQNNGRSETTKSRP-ETPKQKGESRPE 712 + T ++ + I + + N +N L +TK + + S T R E PK E + Sbjct: 648 TCDTFGNEDFNNIQDSENNLLKNNLLNTKLEKSLEEKNESLTEHPRSTELPKTHIE---Q 704 Query: 713 TPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKHRHDNRRDSGKPS 772 K S+ + E + D + + + E P + + H +N S + Sbjct: 705 IQKHFSEDNNEMIPMECDSFC-SDQNESEVEPSVNADLKQMNENSVTHCSENNMPSSDLA 763 Query: 773 TEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRRDHDNKQKSDDRGESER 832 EK VS+ + K + K R + R S + S +D ++K R Sbjct: 764 DEKVETVSQPSESPKDTIDKTKKPRTR--RSRFHSPSTTWSPNKDTPQEKKRPQSPSPRR 821 Query: 833 HRGDQSRVRR-PETLRSSSRNEHGIKSDSSKTDKLERKHRHESGDSRERPSSGEQKSRPD 891 G +SR + P S+R +S S K D + + +S + + ++S Sbjct: 822 ETGKESRKSQSPSPKNESARGRKKSRSQSPKKDIARERRQSQSRSPKRDTTRESRRSESL 881 Query: 892 SPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNKSKVDTNKAHPDNK 938 SPR + NK ++ SP K ++ +S D + + + Sbjct: 882 SPRRETSRENKRSQPRVKDSSPGEKSRSQSRERESDRDGQRRERERR 928 Score = 37.7 bits (86), Expect = 0.15 Identities = 38/146 (26%), Positives = 63/146 (43%), Gaps = 14/146 (9%) Query: 1023 KSRSSLKPI-KNKPSKSNKGSIDQSVLKELPPELLAEIESTMPLCERVKMNKRKRSTV-- 1079 +SR S P KN+ ++ K S QS K++ E + +S P + + ++R S Sbjct: 826 ESRKSQSPSPKNESARGRKKSRSQSPKKDIARER-RQSQSRSPKRDTTRESRRSESLSPR 884 Query: 1080 NEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHEGRR 1139 E + + S DS +S + +++ D+ + ER+RR+ R HS Sbjct: 885 RETSRENKRSQPRVKDSSPGEKSRSQSRERESDRDGQRRERERRTRKWSRSRSHSR---- 940 Query: 1140 SSGGGRYRNRSPSDS----DMEDYSP 1161 R R +S S S D + YSP Sbjct: 941 --SPSRCRTKSKSSSFGRIDRDSYSP 964 >gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] Length = 793 Score = 68.2 bits (165), Expect = 1e-10 Identities = 91/478 (19%), Positives = 189/478 (39%), Gaps = 34/478 (7%) Query: 476 EIERIERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGS 535 EIE E + ++ ++ ++ K K+++++ + G+ G N+ T Sbjct: 161 EIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQ 220 Query: 536 RPALMVSIDLHQAGRVD--SQASITQDSDSI----KKPEEIKQCNDAPVSVLQEDIVGSL 589 +++S+ Q + + Q SD I K EE K+ +A + L+ + + Sbjct: 221 EETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI 280 Query: 590 KSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPN----ENRLVETKSSENKLETKVE 645 K+ + + + + E K+ ++ E R AE + E R E + + E + Sbjct: 281 KAEQDKKIADERARIEAE-EKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAA 339 Query: 646 TQTEELKQNESRTTE----CKQNESTIVEPKQNENRLSDTKPN-DNKQNNGRSETTKSRP 700 + + +K+ E R E K+ E E +Q + K + ++ N + E K Sbjct: 340 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAM 399 Query: 701 ETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETP--KQKGESRPETPKQKNEGRPET- 757 + K KGE +QK +G K+ + + +T K++GE + + K E E Sbjct: 400 QETKIKGEK----VEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDK 455 Query: 758 PKHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQ----------RPDG 807 P + + +D ++ E K D K +KS+ E + RP G Sbjct: 456 PTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGG 515 Query: 808 RSVSESLRRDHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLE 867 R+ ++ + + ++ R E R R ++ E L+ + E ++ + K + E Sbjct: 516 RASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLK-QKQQEAALELEELKKKREE 574 Query: 868 RKHRHESGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGFKSPTSKDDKRTEGNK 925 R+ E + R + ++K R + + + + + R + K +D ++ K Sbjct: 575 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 632 Score = 48.1 bits (113), Expect = 1e-04 Identities = 88/501 (17%), Positives = 201/501 (40%), Gaps = 48/501 (9%) Query: 317 DSPERKQKKQKKMKLGKDEKEQSEKAAMYDIISSPSKDSTK-LTLRLSRVRSSDMDQQED 375 + E+++++++K K G + Q E M + ++ S++ T ++L+ ++ S + Q+E+ Sbjct: 186 EDKEKEEEEEEKPKRGSIGENQVE--VMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243 Query: 376 MISGVENSNVSENDIPFNVQYPGQTSKTPITPQDINRPLNAAQCLSQQEQTAFLPANQVP 435 G + + E + + + + + ++ R + A Q ++ A + A + Sbjct: 244 REQGSDEISHHEK-MEEEDKERAEAERARLEAEERER-IKAEQDKKIADERARIEAEEKA 301 Query: 436 VLQQNTSVAAKQPQTS-------------VVQNQQQISQQGPIYDEVELDALAEIERI-- 480 Q+ A++ + + + +++ +++ E E A E +RI Sbjct: 302 AAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKE 361 Query: 481 -ERESAIERERFSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGS---- 535 E+ +A ER+R E ++K K ++++K++ +E A + ++ G Sbjct: 362 EEKRAAEERQRARAEEEEKAK-VEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNE 420 Query: 536 --------RPALMVSIDLHQAGRVDSQASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVG 587 + A++ + +V ++ Q+ K EEIK +E++ Sbjct: 421 KKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKS 480 Query: 588 SLKSTPENHPETPKKKSDPELSKSEMKQSESRLAESKPNENRLVETKSSENKLETKVETQ 647 + T K + E ++K +E+ S+P V+TK +E + + + Sbjct: 481 FMD---RKKGFTEVKSQNGEFMTHKLKHTENTF--SRPGGRASVDTKEAEGAPQVEAGKR 535 Query: 648 TEELKQNESRT-------TECKQNESTIVEPKQNENRLSDTKPNDNKQNNGRSETTKSRP 700 EEL++ T + KQ E+ + + + R K + ++ + E + Sbjct: 536 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 595 Query: 701 ETPKQKGESRPETPKQKSDGHPETPKQKGDGRPETPKQKGESRPETPKQKNEGRPETPKH 760 ++K + E +++++ + K DG + K P+ K E R E Sbjct: 596 REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEF--L 653 Query: 761 RHDNRRDSGKPSTEKKPEVSK 781 ++ SG ST + VSK Sbjct: 654 NKSVQKSSGVKSTHQAAIVSK 674 Score = 45.8 bits (107), Expect = 6e-04 Identities = 86/502 (17%), Positives = 189/502 (37%), Gaps = 47/502 (9%) Query: 422 QQEQTAFLPANQVPVLQQNTSVAAKQPQTSVVQNQQQISQQGPIYDEVELDALAEIERIE 481 Q+E++ +QV V QN SV ++ +T+ Q + + + + A E R + Sbjct: 54 QEEESLGQVTDQVEVNAQN-SVPDEEAKTTTTNTQVEGDDEAAFLERL---ARREERRQK 109 Query: 482 R-ESAIERER-FSKEVQDKDKPLKKRKQDSYPQEAGGATGGNRPASQETGSTGNGSRPAL 539 R + A+ER++ F + D L R+ + T N +E S R + Sbjct: 110 RLQEALERQKEFDPTITDASLSLPSRRMQN-------DTAENETTEKEEKSESRQERYEI 162 Query: 540 MVSIDLHQAGRVDS--QASITQDSDSIKKPEEIKQCNDAPVSVLQEDIVGSLKSTPENHP 597 + + ++ + + A + D K+ EE ++ + Q +++ K+T Sbjct: 163 EETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEE 222 Query: 598 ETPKKKSDPELSKSEMKQSESRLAESKP-NENRLVETKSSENKLETKVETQTEELKQNES 656 + ++S E KQ E R S + + +E + E + + EE ++ ++ Sbjct: 223 TVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKA 282 Query: 657 RTTECKQNESTIVEPKQN------ENRLSDTKPNDNKQNNGRSETTKSRPETPKQKGESR 710 + +E +E ++ E R ++ + ++ +E + E K+ E R Sbjct: 283 EQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEER 342 Query: 711 PETPKQKSDGHPETPKQKGDGRP-----ETPKQKGESRPETPKQKNEGRPETPKHRHDN- 764 +++ E + K + + + + + E + + +QK + E KH Sbjct: 343 QRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQET 402 Query: 765 --------RRDSGKPSTEKKPEVSKHKQDTKSDSPRLKSERAEALKQRPDGRSVSESLRR 816 ++ GK EKK + K + K + +A + E L+ Sbjct: 403 KIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKR---------EKLQE 453 Query: 817 DHDNKQKSDDRGESERHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERKHRHESGD 876 D +K + + E+ + D+ ++ + +KS + + + KH + Sbjct: 454 DKPTFKKEEIK--DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFS 511 Query: 877 SRERPSSGEQKSRPDSPRVKQG 898 +S + K +P+V+ G Sbjct: 512 RPGGRASVDTKEAEGAPQVEAG 533 Score = 38.5 bits (88), Expect = 0.090 Identities = 88/505 (17%), Positives = 183/505 (36%), Gaps = 85/505 (16%) Query: 759 KHRHDNRRDSGKPSTEKKPEVSKHKQDTKSDSP---RLKSERAEALKQRPDGRSVSESLR 815 + R + RR + + ++ + D + R + R E L+Q+ + S+ + Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64 Query: 816 RDHDNKQKSDDRGESE------RHRGDQSRVRRPETLRSSSRNEHGIKSDSSKTDKLERK 869 + N Q S E++ + GD R R + ++ + LER+ Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQ------EALERQ 118 Query: 870 HRHE---SGDSRERPSSGEQKSRPDSPRVKQGDSNKSRSDKLGF-------KSPTSKDDK 919 + + S PS Q ++ ++ + ++SR ++ KS D + Sbjct: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178 Query: 920 RTEGNKSKVDTNKAHPDNKAEFPSYLLGGRSGALKNFVIPKIKRDKDGNVTQETKKMEMK 979 E NK + +K + + E P + G++ + + +K +ET M +K Sbjct: 179 DAEENKKE---DKEKEEEEEEKP------KRGSIGENQVEVMVEEKTTESQEETVVMSLK 229 Query: 980 G------EPKDKVEKIGLVEDLNKGAKPVVVLQKLSLDDVQKLIKDR---EDKSRSSLKP 1030 EPK + E+ +G+ + +K+ +D ++ +R E + R +K Sbjct: 230 NGQISSEEPKQEEER-------EQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKA 282 Query: 1031 IKNKPSKSNKGSIDQSVL--------------KELPPELLAEIESTMPLCERVKMNKRKR 1076 ++K + I+ + + E E + E K +R Sbjct: 283 EQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEER 342 Query: 1077 STVNEKPKYAEISSDEDNDSDEAFESSRKRHKKDDDKAWEYEERDRRSSGDHRRSGHSHE 1136 + E+ K A + ++ R+R + ++++ + EE+ R + ++ H+ + Sbjct: 343 QRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKK--HAMQ 400 Query: 1137 GRRSSG-------GGRYRNRSPSDSDMEDYSPPPSLSEVARKMKKKEKQKKRKAYEPKLT 1189 + G G++ N + D L K + +EK K +A KL Sbjct: 401 ETKIKGEKVEQKIEGKWVNEKKAQED--------KLQTAVLKKQGEEKGTKVQAKREKL- 451 Query: 1190 PEEMMDSSTFKRFTASIENILDNLE 1214 D TFK+ E I + E Sbjct: 452 ---QEDKPTFKKEEIKDEKIKKDKE 473 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.312 0.128 0.355 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 102,105,928 Number of Sequences: 37866 Number of extensions: 5002241 Number of successful extensions: 36972 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 181 Number of HSP's successfully gapped in prelim test: 1307 Number of HSP's that attempted gapping in prelim test: 22794 Number of HSP's gapped (non-prelim): 11606 length of query: 2697 length of database: 18,247,518 effective HSP length: 120 effective length of query: 2577 effective length of database: 13,703,598 effective search space: 35314172046 effective search space used: 35314172046 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.