Guide to the Human Genome
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Search of human proteins with 4755140

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4755140 inositol polyphosphate-4-phosphatase, type 1 isoform
a [Homo sapiens]
         (938 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4755140 inositol polyphosphate-4-phosphatase, type 1 isoform ...  1875   0.0  
gi|197116359 inositol polyphosphate-4-phosphatase, type 1 isofor...  1853   0.0  
gi|197116361 inositol polyphosphate-4-phosphatase, type 1 isofor...  1833   0.0  
gi|4504705 inositol polyphosphate-4-phosphatase, type 1 isoform ...  1791   0.0  
gi|156104897 inositol polyphosphate-4-phosphatase, type II, 105k...   738   0.0  
gi|156104895 inositol polyphosphate-4-phosphatase, type II, 105k...   738   0.0  
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]          122   1e-27
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...   120   8e-27
gi|88703066 copine-like protein [Homo sapiens]                         36   0.15 
gi|25141328 copine 7 isoform a [Homo sapiens]                          35   0.25 
gi|7656993 copine 7 isoform b [Homo sapiens]                           35   0.25 
gi|25141323 copine V [Homo sapiens]                                    35   0.33 
gi|45269137 mitofusin 1 [Homo sapiens]                                 34   0.56 
gi|25121972 copine VIII [Homo sapiens]                                 34   0.73 
gi|126116565 MYC binding protein 2 [Homo sapiens]                      33   1.2  
gi|34304360 nephrocystin 3 [Homo sapiens]                              33   1.6  
gi|95147555 microtubule-associated protein 1A [Homo sapiens]           33   1.6  
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo...    33   1.6  
gi|189083768 mitofusin 2 [Homo sapiens]                                32   2.8  
gi|7662004 mitofusin 2 [Homo sapiens]                                  32   2.8  
gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Hom...    32   3.6  
gi|64464726 KN motif and ankyrin repeat domains 1 isoform a [Hom...    32   3.6  
gi|223278381 ribosomal RNA processing 12 homolog isoform 2 [Homo...    30   8.1  
gi|223278379 ribosomal RNA processing 12 homolog isoform 1 [Homo...    30   8.1  
gi|5730102 transient receptor potential cation channel, subfamil...    30   8.1  
gi|157676340 zinc finger protein 142 [Homo sapiens]                    30   8.1  
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom...    30   8.1  
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom...    30   8.1  
gi|16933559 protocadherin LKC precursor [Homo sapiens]                 30   8.1  

>gi|4755140 inositol polyphosphate-4-phosphatase, type 1 isoform a
           [Homo sapiens]
          Length = 938

 Score = 1875 bits (4856), Expect = 0.0
 Identities = 938/938 (100%), Positives = 938/938 (100%)

Query: 1   MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSL 60
           MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSL
Sbjct: 1   MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSL 60

Query: 61  DRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVY 120
           DRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVY
Sbjct: 61  DRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVY 120

Query: 121 DVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQR 180
           DVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQR
Sbjct: 121 DVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQR 180

Query: 181 PPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDG 240
           PPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDG
Sbjct: 181 PPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDG 240

Query: 241 NHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT 300
           NHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT
Sbjct: 241 NHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT 300

Query: 301 IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTI 360
           IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTI
Sbjct: 301 IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTI 360

Query: 361 GAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINT 420
           GAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINT
Sbjct: 361 GAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINT 420

Query: 421 LKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPD 480
           LKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPD
Sbjct: 421 LKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPD 480

Query: 481 YIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLEC 540
           YIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLEC
Sbjct: 481 YIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLEC 540

Query: 541 IIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKDCSPPPEESSPGEWSEALYPLLTTLTD 600
           IIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKDCSPPPEESSPGEWSEALYPLLTTLTD
Sbjct: 541 IIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKDCSPPPEESSPGEWSEALYPLLTTLTD 600

Query: 601 CVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHD 660
           CVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHD
Sbjct: 601 CVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHD 660

Query: 661 DGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLP 720
           DGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLP
Sbjct: 661 DGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLP 720

Query: 721 VITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQ 780
           VITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQ
Sbjct: 721 VITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQ 780

Query: 781 EVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQ 840
           EVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQ
Sbjct: 781 EVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQ 840

Query: 841 AAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRR 900
           AAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRR
Sbjct: 841 AAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRR 900

Query: 901 ENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET 938
           ENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET
Sbjct: 901 ENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET 938


>gi|197116359 inositol polyphosphate-4-phosphatase, type 1 isoform d
           [Homo sapiens]
          Length = 977

 Score = 1853 bits (4799), Expect = 0.0
 Identities = 937/977 (95%), Positives = 937/977 (95%), Gaps = 39/977 (3%)

Query: 1   MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSL 60
           MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSL
Sbjct: 1   MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSL 60

Query: 61  DRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVY 120
           DRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVY
Sbjct: 61  DRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVY 120

Query: 121 DVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQR 180
           DVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQR
Sbjct: 121 DVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQR 180

Query: 181 PPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDG 240
           PPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDG
Sbjct: 181 PPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDG 240

Query: 241 NHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT 300
           NHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT
Sbjct: 241 NHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT 300

Query: 301 IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTI 360
           IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTI
Sbjct: 301 IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTI 360

Query: 361 GAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINT 420
           GAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINT
Sbjct: 361 GAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINT 420

Query: 421 LKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPD 480
           LKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPD
Sbjct: 421 LKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPD 480

Query: 481 YIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLEC 540
           YIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLEC
Sbjct: 481 YIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLEC 540

Query: 541 IIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKK--------------------------- 573
           IIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKK                           
Sbjct: 541 IIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKGNPDSHAYWIRPEDPFCDVPSSPCPST 600

Query: 574 ------------DCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDS 621
                        CSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDS
Sbjct: 601 MPSTACHPHLTTHCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDS 660

Query: 622 APTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLS 681
           APTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLS
Sbjct: 661 APTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLS 720

Query: 682 TYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFD 741
           TYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFD
Sbjct: 721 TYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFD 780

Query: 742 ALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEV 801
           ALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEV
Sbjct: 781 ALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEV 840

Query: 802 LPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKD 861
           LPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKD
Sbjct: 841 LPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKD 900

Query: 862 RTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKA 921
           RTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKA
Sbjct: 901 RTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKA 960

Query: 922 FPKHYRPPEGTYGKVET 938
           FPKHYRPPEGTYGKVET
Sbjct: 961 FPKHYRPPEGTYGKVET 977


>gi|197116361 inositol polyphosphate-4-phosphatase, type 1 isoform c
           [Homo sapiens]
          Length = 972

 Score = 1833 bits (4749), Expect = 0.0
 Identities = 932/977 (95%), Positives = 932/977 (95%), Gaps = 44/977 (4%)

Query: 1   MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSL 60
           MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSL
Sbjct: 1   MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSL 60

Query: 61  DRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVY 120
           DRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVY
Sbjct: 61  DRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVY 120

Query: 121 DVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQR 180
           DVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQR
Sbjct: 121 DVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQR 180

Query: 181 PPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDG 240
           PPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDG
Sbjct: 181 PPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDG 240

Query: 241 NHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT 300
           NHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT
Sbjct: 241 NHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT 300

Query: 301 IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTI 360
           IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTI
Sbjct: 301 IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTI 360

Query: 361 GAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINT 420
           GAPAAHCQGFKSGGLRKKLHKFEETKKH     TSSGCQSIIYIPQDVVRAKEIIAQINT
Sbjct: 361 GAPAAHCQGFKSGGLRKKLHKFEETKKH-----TSSGCQSIIYIPQDVVRAKEIIAQINT 415

Query: 421 LKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPD 480
           LKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPD
Sbjct: 416 LKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPD 475

Query: 481 YIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLEC 540
           YIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLEC
Sbjct: 476 YIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLEC 535

Query: 541 IIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKK--------------------------- 573
           IIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKK                           
Sbjct: 536 IIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKGNPDSHAYWIRPEDPFCDVPSSPCPST 595

Query: 574 ------------DCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDS 621
                        CSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDS
Sbjct: 596 MPSTACHPHLTTHCSPPPEESSPGEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDS 655

Query: 622 APTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLS 681
           APTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLS
Sbjct: 656 APTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQFESLLS 715

Query: 682 TYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFD 741
           TYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFD
Sbjct: 716 TYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPLPGPLFD 775

Query: 742 ALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEV 801
           ALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEV
Sbjct: 776 ALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEV 835

Query: 802 LPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKD 861
           LPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKD
Sbjct: 836 LPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTSCKSAKD 895

Query: 862 RTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKA 921
           RTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKA
Sbjct: 896 RTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKA 955

Query: 922 FPKHYRPPEGTYGKVET 938
           FPKHYRPPEGTYGKVET
Sbjct: 956 FPKHYRPPEGTYGKVET 972


>gi|4504705 inositol polyphosphate-4-phosphatase, type 1 isoform b
           [Homo sapiens]
          Length = 954

 Score = 1791 bits (4640), Expect = 0.0
 Identities = 900/907 (99%), Positives = 901/907 (99%)

Query: 1   MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSL 60
           MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSL
Sbjct: 1   MTAREHSPRHGARARAMQRASTIDVAADMLGLSLAGNIQDPDEPILEFSLACSELHTPSL 60

Query: 61  DRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVY 120
           DRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVY
Sbjct: 61  DRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQVKLSVY 120

Query: 121 DVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQR 180
           DVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQR
Sbjct: 121 DVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQR 180

Query: 181 PPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDG 240
           PPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDG
Sbjct: 181 PPVTRSVDTVNGRMVLPVDESLTEALGIRSKYASLRKDTLLKSVFGGAICRMYRFPTTDG 240

Query: 241 NHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT 300
           NHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT
Sbjct: 241 NHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQT 300

Query: 301 IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTI 360
           IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTI
Sbjct: 301 IILTYQENLTDLHQYRGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTI 360

Query: 361 GAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINT 420
           GAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINT
Sbjct: 361 GAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINT 420

Query: 421 LKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPD 480
           LKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPD
Sbjct: 421 LKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPD 480

Query: 481 YIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLEC 540
           YIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLEC
Sbjct: 481 YIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLEC 540

Query: 541 IIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKDCSPPPEESSPGEWSEALYPLLTTLTD 600
           IIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKDCSPPPEESSPGEWSEALYPLLTTLTD
Sbjct: 541 IIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKDCSPPPEESSPGEWSEALYPLLTTLTD 600

Query: 601 CVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHD 660
           CVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHD
Sbjct: 601 CVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHD 660

Query: 661 DGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLP 720
           DGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLP
Sbjct: 661 DGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLP 720

Query: 721 VITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQ 780
           VITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQ
Sbjct: 721 VITGNRDGFNVRVPLPGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQ 780

Query: 781 EVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQ 840
           EVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQ
Sbjct: 781 EVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQ 840

Query: 841 AAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRR 900
           AAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRS G R 
Sbjct: 841 AAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSIGTRE 900

Query: 901 ENTMKNV 907
             T KN+
Sbjct: 901 VVTQKNL 907


>gi|156104897 inositol polyphosphate-4-phosphatase, type II, 105kD
           [Homo sapiens]
          Length = 924

 Score =  738 bits (1905), Expect = 0.0
 Identities = 413/923 (44%), Positives = 586/923 (63%), Gaps = 59/923 (6%)

Query: 41  PDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSS 100
           P+EP LEF LAC +L  P  DRK N+ V +SV  P +   T+++ TEI+EGT +P+FL+ 
Sbjct: 36  PNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTG 95

Query: 101 IAFFQDSLINQMTQVKLSVYDVKDRSQGTMY-----------------LLGSGTFIVKDL 143
           + F  +  I + T++KL+VYDVKD+S  T+                   LG  +F V +L
Sbjct: 96  VTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGEL 155

Query: 144 LQDRHHRLHLTLRSAESDRV-GNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESL 202
           L+ +   L L+LR+++  +V G I V   +M E  D       + D    +  L  + + 
Sbjct: 156 LKSKEQLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHI-TTDVQGQKCALVCECTA 214

Query: 203 TEALGIRSKYASLRKDTL--LKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPR 260
            E++          KD L  L SV    +C++YRFPT+D   +RI EQM+ES+LS H+P+
Sbjct: 215 PESVS--------GKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPK 266

Query: 261 QFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSF 320
           + + L ++ED  R  E++ELGELSP W++LR+ ++T    ++  YQ+ LT+L +  G SF
Sbjct: 267 ELISLHIKEDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSF 326

Query: 321 KASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLH 380
           K+SS K +K LEFVP NLH+QRM+V      D  YD++T+GAPAAH QGFK+GGLRK LH
Sbjct: 327 KSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLH 386

Query: 381 KFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRS 440
           +FE  +++       +G Q I Y P++  +AKE+++ IN L+  ++ +A+ L  +A   S
Sbjct: 387 RFETERRN-------TGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHS 439

Query: 441 ATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKA-SPTSTEEEQVMLR 499
              L+ +L +L++KT   V     +L+ +++  L  ARP  I  K  SP S+ EE     
Sbjct: 440 PDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSP-- 497

Query: 500 NDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGC 559
            DQ  +M    G++S      D+ EEEW++VW NV KSL CII  VDKL++++     G 
Sbjct: 498 QDQPPVMR---GQDSIPH-HSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDG----GS 549

Query: 560 EDVFPCAGSCTSKKDCSPPPEESSPG----EWSEALYPLLTTLTDCVAMMSDKAKKAMVF 615
           E      G+   +K+  P   ++ P     +W E LYPL+ TL DC+  + ++AK+++ F
Sbjct: 550 EG---SGGNNDGEKE--PSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTF 604

Query: 616 LLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQ 675
           +L+Q+ A ++   L L  RRD+VF Q L  L+CGFIIKL+  L+D GFL+QL+T+GL+ Q
Sbjct: 605 VLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQ 664

Query: 676 FESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPL 735
           +E LLSTY +E+ MLEDM++GI DL+ V FK+ +A S+   D+LPVITG R+ + V V L
Sbjct: 665 YEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSN---DVLPVITGRREHYVVEVKL 721

Query: 736 PGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYF 795
           P  +F++LP +I+ G LL V PVLFNVGINEQQTLAERFGD SLQE IN E+   L  Y+
Sbjct: 722 PARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYY 781

Query: 796 EQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTS 855
           + F E +P D +   + Q  L  LL  L QN+ ++K KNV+I+W AA ICR+LNG+RFT 
Sbjct: 782 KIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTC 841

Query: 856 CKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFN 915
           CKSAKDRT+MSVTLEQC IL+ EH +    F +AL+CMR EGCR EN +KN+  RKYAFN
Sbjct: 842 CKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFN 901

Query: 916 SLQLKAFPKHYRPPEGTYGKVET 938
            LQL AFPK+YRPPEGTYGK +T
Sbjct: 902 MLQLMAFPKYYRPPEGTYGKADT 924


>gi|156104895 inositol polyphosphate-4-phosphatase, type II, 105kD
           [Homo sapiens]
          Length = 924

 Score =  738 bits (1905), Expect = 0.0
 Identities = 413/923 (44%), Positives = 586/923 (63%), Gaps = 59/923 (6%)

Query: 41  PDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSS 100
           P+EP LEF LAC +L  P  DRK N+ V +SV  P +   T+++ TEI+EGT +P+FL+ 
Sbjct: 36  PNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTG 95

Query: 101 IAFFQDSLINQMTQVKLSVYDVKDRSQGTMY-----------------LLGSGTFIVKDL 143
           + F  +  I + T++KL+VYDVKD+S  T+                   LG  +F V +L
Sbjct: 96  VTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGEL 155

Query: 144 LQDRHHRLHLTLRSAESDRV-GNITVIGWQMEEKSDQRPPVTRSVDTVNGRMVLPVDESL 202
           L+ +   L L+LR+++  +V G I V   +M E  D       + D    +  L  + + 
Sbjct: 156 LKSKEQLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHI-TTDVQGQKCALVCECTA 214

Query: 203 TEALGIRSKYASLRKDTL--LKSVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPR 260
            E++          KD L  L SV    +C++YRFPT+D   +RI EQM+ES+LS H+P+
Sbjct: 215 PESVS--------GKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPK 266

Query: 261 QFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPSF 320
           + + L ++ED  R  E++ELGELSP W++LR+ ++T    ++  YQ+ LT+L +  G SF
Sbjct: 267 ELISLHIKEDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSF 326

Query: 321 KASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLH 380
           K+SS K +K LEFVP NLH+QRM+V      D  YD++T+GAPAAH QGFK+GGLRK LH
Sbjct: 327 KSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLH 386

Query: 381 KFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRS 440
           +FE  +++       +G Q I Y P++  +AKE+++ IN L+  ++ +A+ L  +A   S
Sbjct: 387 RFETERRN-------TGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHS 439

Query: 441 ATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKA-SPTSTEEEQVMLR 499
              L+ +L +L++KT   V     +L+ +++  L  ARP  I  K  SP S+ EE     
Sbjct: 440 PDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSP-- 497

Query: 500 NDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGC 559
            DQ  +M    G++S      D+ EEEW++VW NV KSL CII  VDKL++++     G 
Sbjct: 498 QDQPPVMR---GQDSIPH-HSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDG----GS 549

Query: 560 EDVFPCAGSCTSKKDCSPPPEESSPG----EWSEALYPLLTTLTDCVAMMSDKAKKAMVF 615
           E      G+   +K+  P   ++ P     +W E LYPL+ TL DC+  + ++AK+++ F
Sbjct: 550 EG---SGGNNDGEKE--PSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTF 604

Query: 616 LLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDDGFLRQLYTIGLLAQ 675
           +L+Q+ A ++   L L  RRD+VF Q L  L+CGFIIKL+  L+D GFL+QL+T+GL+ Q
Sbjct: 605 VLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQ 664

Query: 676 FESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVITGNRDGFNVRVPL 735
           +E LLSTY +E+ MLEDM++GI DL+ V FK+ +A S+   D+LPVITG R+ + V V L
Sbjct: 665 YEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSN---DVLPVITGRREHYVVEVKL 721

Query: 736 PGPLFDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYF 795
           P  +F++LP +I+ G LL V PVLFNVGINEQQTLAERFGD SLQE IN E+   L  Y+
Sbjct: 722 PARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYY 781

Query: 796 EQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEICRRLNGVRFTS 855
           + F E +P D +   + Q  L  LL  L QN+ ++K KNV+I+W AA ICR+LNG+RFT 
Sbjct: 782 KIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTC 841

Query: 856 CKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFN 915
           CKSAKDRT+MSVTLEQC IL+ EH +    F +AL+CMR EGCR EN +KN+  RKYAFN
Sbjct: 842 CKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFN 901

Query: 916 SLQLKAFPKHYRPPEGTYGKVET 938
            LQL AFPK+YRPPEGTYGK +T
Sbjct: 902 MLQLMAFPKYYRPPEGTYGKADT 924


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score =  122 bits (307), Expect = 1e-27
 Identities = 192/857 (22%), Positives = 337/857 (39%), Gaps = 163/857 (19%)

Query: 175  EKSDQRPPVTRSVDTVNGRMVLPVDESLTEAL-GIRSKYASLRKDTLLKSVFGGAICRMY 233
            +KS  +PP   + D  + ++   +D+  T A+   + ++ SL  D +      G +   Y
Sbjct: 769  QKSHSKPPGDEAGDAFDCKVEEVIDKFNTMAIIDGKKEHVSLTVDNVHLEY--GVV---Y 823

Query: 234  RFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARV---CELEELGELSPC---- 286
             + +T G    ++E+M E      +  + ++ L + D   V     L  L E+ P     
Sbjct: 824  EYDSTAGIKCNVVEKMIEPKGFFSLTAKILEALAKSDEHFVQNCTSLNSLNEVIPTDLQS 883

Query: 287  -WESLRRQIVTQYQTIILTYQENLTDLHQYRGPSFKASSLKADK--KLEFVPTNLHIQRM 343
             + +L  + +      I +Y++    L     P+FK +  K       +F PTN H+  M
Sbjct: 884  KFSALCSERIEHLCQRISSYKKFSRVLKNRAWPTFKQAKSKISPLHSSDFCPTNCHVNVM 943

Query: 344  R---------------VQDDGGSDQNYD--------------------IVTIGAPAAHCQ 368
                            VQ D     ++D                    I T+ AP+    
Sbjct: 944  EVSYPKTSTSLGSAFGVQLDSRKHNSHDKENKSSEQGKLSPMVYIQHTITTMAAPSGLSL 1003

Query: 369  GFKSG-GLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEI-IAQINTLKTQVS 426
            G + G GLR  L +        E+  T    Q ++   Q  ++  E+ + QI+ L + ++
Sbjct: 1004 GQQDGHGLRYLLKE--------EDLETQDIYQKLLGKLQTALKEVEMCVCQIDDLLSSIT 1055

Query: 427  YYAERLSRAAKDRSATGLERTLAILADKTRQLVTVC-------------DCKLLANSIHG 473
            Y + +L R    +++ G+  T +      R    VC             D     +S   
Sbjct: 1056 Y-SPKLER----KTSEGIIPTDSDNEKGERNSKRVCFNVAGDEQEDSGHDTISNRDSYSD 1110

Query: 474  LNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLN 533
             N+ R + IAS  S  S++       ++ D+      G     S+++   +++       
Sbjct: 1111 CNSNR-NSIASFTSICSSQCSSYFHSDEMDS------GDELPLSVRISHDKQD------K 1157

Query: 534  VDKSLECIIQRVDKLLQKERLHGEGCEDVFPCAGSCTSKKDCSPPPEESSP--------- 584
            +   LE +  +VD +     L G+     F      T  +      +E  P         
Sbjct: 1158 IHSCLEHLFSQVDSITNL--LKGQAVVRAFDQTKYLTPGRGLQEFQQEMEPKLSCPKRLR 1215

Query: 585  -----GEWSEALYPLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVF 639
                   W+  L   + TL   +    ++ K  ++  L++ S          Q RRD+VF
Sbjct: 1216 LHIKQDPWN--LPSSVRTLAQNIRKFVEEVKCRLLLALLEYSDS------ETQLRRDMVF 1267

Query: 640  CQTLTALICGFIIKLR---NCLHDDG-------------FLRQLYTIGLLAQFESLLS-T 682
            CQTL A +C F  +L    N + D+              +L Q+   G+L  F+SLLS  
Sbjct: 1268 CQTLVATVCAFSEQLMAALNQMFDNSKENEMETWEASRRWLDQIANAGVLFHFQSLLSPN 1327

Query: 683  YGEELAMLEDMSLGIMDLRNVTFKVTQATSSASADMLPVI---TGNRDGFNVRVPLPGPL 739
              +E AMLED  + + DL  V+F    +        +P+     G+R    V   +    
Sbjct: 1328 LTDEQAMLEDTLVALFDLEKVSFYFKPSEEEPLVANVPLTYQAEGSRQALKVYFYIDSYH 1387

Query: 740  FDALPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEV---INVESLVRLNSYFE 796
            F+ LP+ +++G   ++ PVLF   +   +    R  + S++E    IN  SL ++  Y +
Sbjct: 1388 FEQLPQRLKNGGGFKIHPVLFAQALESMEGYYYR-DNVSVEEFQAQINAASLEKVKQYNQ 1446

Query: 797  QFKEVLPE--DCLPRSRSQTC-----------LPELLRFLGQNVHARKN----------K 833
            + +    +  +  P S S+             L EL R +   + +++            
Sbjct: 1447 KLRAFYLDKSNSPPNSTSKAAYVDKLMRPLNALDELYRLVASFIRSKRTAACANTACSAS 1506

Query: 834  NVDILWQAAEICRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECM 893
             V +L  ++E+C RL       C S   R  +SVTLEQ +IL   HG+ P+   QA + M
Sbjct: 1507 GVGLLSVSSELCNRLGACHIIMCSSGVHRCTLSVTLEQAIILARSHGLPPRYIMQATDVM 1566

Query: 894  RSEGCRRENTMKNVGSR 910
            R +G R +NT KN+G R
Sbjct: 1567 RKQGARVQNTAKNLGVR 1583


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
            exchange factor 1 [Homo sapiens]
          Length = 1659

 Score =  120 bits (300), Expect = 8e-27
 Identities = 101/352 (28%), Positives = 157/352 (44%), Gaps = 45/352 (12%)

Query: 595  LTTLTDCVAMMSDKAKKAMVFLLMQDSAPTIATYLSLQYRRDVVFCQTLTALICGFIIKL 654
            + TL D +    +  K  ++  L++       T   LQ RRD +FCQ L A +C F  +L
Sbjct: 1289 IKTLVDNIQRYVEDGKNQLLLALLK------CTDTELQLRRDAIFCQALVAAVCTFSEQL 1342

Query: 655  RNCL----HDDG------------FLRQLYTIGLLAQFESLLS--TYGEELAMLEDMSLG 696
               L    +++G            +L Q+   G+L   +SLLS  T  EE  MLED+ + 
Sbjct: 1343 LAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHCQSLLSPATVKEERTMLEDIWVT 1402

Query: 697  IMDLRNVTFKVTQATSS--ASADMLPVITGNRDGFNVRVPLPGPLFDALPREIQSGMLLR 754
            + +L NVTF   Q   +  A+ ++   I G+R    V   L    F  LP  ++ G  LR
Sbjct: 1403 LSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVIFYLDSYHFSKLPSRLEGGASLR 1462

Query: 755  VQPVLFNVGINEQQTLAERFGDTS--LQEVINVESLVRLNSYFEQFKEV-LPEDCLPRSR 811
            +   LF   +   + L       +  LQ+ IN +SL ++  Y+ + +   L    LP   
Sbjct: 1463 LHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEKVQQYYRKLRAFYLERSNLPTDA 1522

Query: 812  SQTC------------LPELLRFLGQNVH----ARKNKNVDILWQAAEICRRLNGVRFTS 855
            S T             L EL R +   VH    A  +    ++  ++E+C RL   +   
Sbjct: 1523 STTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSVGAGLIPISSELCYRLGACQMVM 1582

Query: 856  CKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNV 907
            C +   R+ +SV+LEQ  IL   HG+ P+   QA + MR +G R E   KN+
Sbjct: 1583 CGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIMRKQGPRVEILAKNL 1634



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 32/124 (25%), Positives = 51/124 (41%), Gaps = 10/124 (8%)

Query: 232 MYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESL- 290
           +Y + +T G    +LE++ E      +  + ++     D+  V     L  LS    ++ 
Sbjct: 856 VYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVENCRRLMALSSAIVTMP 915

Query: 291 ----RRQIVTQYQTI---ILTYQENLTDLHQYRGPSFKASSLKADKK--LEFVPTNLHIQ 341
               R    T+ ++I   I  YQE    L     P FK + L+      L+F PTN HI 
Sbjct: 916 HFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPHPLCGLDFCPTNCHIN 975

Query: 342 RMRV 345
            M V
Sbjct: 976 LMEV 979


>gi|88703066 copine-like protein [Homo sapiens]
          Length = 553

 Score = 36.2 bits (82), Expect = 0.15
 Identities = 27/135 (20%), Positives = 53/135 (39%), Gaps = 4/135 (2%)

Query: 46  LEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQ 105
           +E +++C  L       K +  V +   +     W +  +TE+I+ T NP F+    F  
Sbjct: 16  IEITVSCRNLLDLDTFSKSDPMVVLYTQSRASQEWREFGRTEVIDNTLNPDFVRK--FVL 73

Query: 106 DSLINQMTQVKLSVYDV--KDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAESDRV 163
           D    +   ++  VY+V  K         LG     + +++  +  R+  TL      + 
Sbjct: 74  DYFFEEKQNLRFDVYNVDSKTNISKPKDFLGQAFLALGEVIGGQGSRVERTLTGVPGKKC 133

Query: 164 GNITVIGWQMEEKSD 178
           G I +   ++    D
Sbjct: 134 GTILLTAEELSNCRD 148


>gi|25141328 copine 7 isoform a [Homo sapiens]
          Length = 558

 Score = 35.4 bits (80), Expect = 0.25
 Identities = 24/88 (27%), Positives = 42/88 (47%), Gaps = 8/88 (9%)

Query: 36  GNIQDPDEPILEFSLACSELHTPSLDRKP--NSFVAVSVTTPPQAFWTKHAQTEIIEGTN 93
           G +  P    +E  L+C  L    LDR P   S  +V++    Q  W +  +TE++  + 
Sbjct: 14  GGLPAPCASKVELRLSCRHL----LDRDPLTKSDPSVALLQQAQGQWVQVGRTEVVRSSL 69

Query: 94  NPIFLSSIAFFQDSLINQMTQVKLSVYD 121
           +P+F  S  F  D    ++ +++  VYD
Sbjct: 70  HPVF--SKVFTVDYYFEEVQRLRFEVYD 95


>gi|7656993 copine 7 isoform b [Homo sapiens]
          Length = 633

 Score = 35.4 bits (80), Expect = 0.25
 Identities = 24/88 (27%), Positives = 42/88 (47%), Gaps = 8/88 (9%)

Query: 36  GNIQDPDEPILEFSLACSELHTPSLDRKP--NSFVAVSVTTPPQAFWTKHAQTEIIEGTN 93
           G +  P    +E  L+C  L    LDR P   S  +V++    Q  W +  +TE++  + 
Sbjct: 14  GGLPAPCASKVELRLSCRHL----LDRDPLTKSDPSVALLQQAQGQWVQVGRTEVVRSSL 69

Query: 94  NPIFLSSIAFFQDSLINQMTQVKLSVYD 121
           +P+F  S  F  D    ++ +++  VYD
Sbjct: 70  HPVF--SKVFTVDYYFEEVQRLRFEVYD 95


>gi|25141323 copine V [Homo sapiens]
          Length = 593

 Score = 35.0 bits (79), Expect = 0.33
 Identities = 23/94 (24%), Positives = 41/94 (43%), Gaps = 5/94 (5%)

Query: 33  SLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGT 92
           SLAG+I       +E +++C  L    +  K +    +         W +  +TE+I+ T
Sbjct: 15  SLAGSIPATK---VEITVSCRNLLDKDMFSKSDPLCVMYTQGMENKQWREFGRTEVIDNT 71

Query: 93  NNPIFLSSIAFFQDSLINQMTQVKLSVYDVKDRS 126
            NP F+    F  D    +   ++  +YDV  +S
Sbjct: 72  LNPDFVRK--FIVDYFFEEKQNLRFDLYDVDSKS 103


>gi|45269137 mitofusin 1 [Homo sapiens]
          Length = 741

 Score = 34.3 bits (77), Expect = 0.56
 Identities = 17/57 (29%), Positives = 31/57 (54%), Gaps = 2/57 (3%)

Query: 374 GLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAE 430
           G   +L +F+  ++ FEEC + S  ++     Q  +RAK+I+A +  +   V+  AE
Sbjct: 309 GFHARLQEFQNFEQIFEECISQSAVKT--KFEQHTIRAKQILATVKNIMDSVNLAAE 363


>gi|25121972 copine VIII [Homo sapiens]
          Length = 564

 Score = 33.9 bits (76), Expect = 0.73
 Identities = 20/81 (24%), Positives = 35/81 (43%), Gaps = 2/81 (2%)

Query: 46  LEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQ 105
           +E S++C  L       K +    + V       W +  +TE+I+ T NP F+    F  
Sbjct: 26  VEVSVSCRNLLDRDTFSKSDPICVLYVQGVGNKEWREFGRTEVIDNTLNPDFVRK--FIL 83

Query: 106 DSLINQMTQVKLSVYDVKDRS 126
           D    +   ++  +YDV  +S
Sbjct: 84  DYFFEERENLRFDLYDVDSKS 104


>gi|126116565 MYC binding protein 2 [Homo sapiens]
          Length = 4640

 Score = 33.1 bits (74), Expect = 1.2
 Identities = 38/137 (27%), Positives = 63/137 (45%), Gaps = 24/137 (17%)

Query: 201  SLTEALGIRSKYASLRKDTLLKSVFGGAICRM-YRFPTTDGNHLRILEQMAESVLSLHVP 259
            S+T   G+  ++ S +K      V  G I ++ YR PT+DG+  +  +Q +E V   H+ 
Sbjct: 1313 SITTDDGVVFQFKSSKKSNNGTDVNAGQIPQLLYRLPTSDGSASKGKQQTSEPV---HI- 1368

Query: 260  RQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPS 319
                   L+   AR   +E       C+ESL   +   + T++L  +E    L   +G  
Sbjct: 1369 -------LKRSFARTVSVE-------CFESLLSILHWSWTTLVLGVEE----LRGLKGFQ 1410

Query: 320  FKASSLKADKKLEFVPT 336
            F A+ L  + +L FV T
Sbjct: 1411 FTATLLDLE-RLRFVGT 1426


>gi|34304360 nephrocystin 3 [Homo sapiens]
          Length = 1330

 Score = 32.7 bits (73), Expect = 1.6
 Identities = 26/116 (22%), Positives = 53/116 (45%), Gaps = 13/116 (11%)

Query: 260 RQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYRGPS 319
           + + K+L E+++A   + + + E +  +E  R ++  Q++    T +  + DL       
Sbjct: 135 KTYQKILREKESALEAKYQAM-ERAATFEHDRDKVKRQFKIFRETKENEIQDL------- 186

Query: 320 FKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGL 375
                L+A ++LE     L  Q ++V D G SD + +   + A    C+ +  G L
Sbjct: 187 -----LRAKRELESKLQRLQAQGIQVFDPGESDSDDNCTDVTAAGTQCEYWTGGAL 237


>gi|95147555 microtubule-associated protein 1A [Homo sapiens]
          Length = 2803

 Score = 32.7 bits (73), Expect = 1.6
 Identities = 40/152 (26%), Positives = 56/152 (36%), Gaps = 14/152 (9%)

Query: 479  PDYIASKASPTSTEEEQVMLRNDQDTL-MARWTGRNSRSSLQVDWHEEEWEKVWLNVDKS 537
            P +      P   E E+  L  D  T+ MA        S+    +H+   E      +KS
Sbjct: 966  PGHALHPGEPALGEAEERCLSPDDSTVKMASPPPSGPPSATHTPFHQSPVE------EKS 1019

Query: 538  LECIIQRVDKLLQKERLHGEGCED-----VFPCAGSCTSKKDCSPPPEESSPGEWSEALY 592
                 Q  D     +R  G G ED     V P     T +K+   PP  S   +  EA  
Sbjct: 1020 EPQDFQEADSWGDTKRTPGVGKEDAAEETVKPGPEEGTLEKEEKVPPPRSPQAQ--EAPV 1077

Query: 593  PLLTTLTDCVAMMSDKAKKAMVFLLMQDSAPT 624
             +   LT C   +     KA+VF +M+   PT
Sbjct: 1078 NIDEGLTGCTIQLLPAQDKAIVFEIMEAGEPT 1109


>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
           sapiens]
          Length = 1866

 Score = 32.7 bits (73), Expect = 1.6
 Identities = 29/111 (26%), Positives = 55/111 (49%), Gaps = 11/111 (9%)

Query: 249 MAESVLSLHVPRQFVKLLLEEDAARVCELE-ELGELSPCWESLRRQIVTQYQTIILTYQE 307
           MAE+   LH+ R   KL L ++   V  +   L  +S CW      I  Q++T+I  + +
Sbjct: 890 MAEAASQLHIAR---KLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMFAQ 946

Query: 308 NLTDLHQYRGPSFKASSLKADKKLEFVPTNLHI--QRMRVQDDGGSDQNYD 356
              +  + +GP  +A+ L  D  +  +P+ L +  +RMR+   G  +++ +
Sbjct: 947 ---EPEEQKGPQERAAFL--DSLMLQMPSELPLSSRRMRLTHCGLQEKHLE 992


>gi|189083768 mitofusin 2 [Homo sapiens]
          Length = 757

 Score = 32.0 bits (71), Expect = 2.8
 Identities = 36/165 (21%), Positives = 64/165 (38%), Gaps = 38/165 (23%)

Query: 305 YQENLTDLHQYRGPSFKASSL------KADKKLEFVPT----NLHIQRMRVQDDGGSDQN 354
           Y E +   H  R  SF    L      +A  ++ FV      N  IQ+ +   +GG    
Sbjct: 269 YMEEVRRQHMERCTSFLVDELGVVDRSQAGDRIFFVSAKEVLNARIQKAQGMPEGG---- 324

Query: 355 YDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEI 414
                         G  + G + ++ +F+  ++ FEEC + S  ++     Q  VRAK+I
Sbjct: 325 --------------GALAEGFQVRMFEFQNFERRFEECISQSAVKT--KFEQHTVRAKQI 368

Query: 415 IAQINTLKTQV-------SYYAERLSRAAKDRSATGLERTLAILA 452
              +  +   +         Y E +    +DR    +++ L +LA
Sbjct: 369 AEAVRLIMDSLHMAAREQQVYCEEMREERQDR-LKFIDKQLELLA 412


>gi|7662004 mitofusin 2 [Homo sapiens]
          Length = 757

 Score = 32.0 bits (71), Expect = 2.8
 Identities = 36/165 (21%), Positives = 64/165 (38%), Gaps = 38/165 (23%)

Query: 305 YQENLTDLHQYRGPSFKASSL------KADKKLEFVPT----NLHIQRMRVQDDGGSDQN 354
           Y E +   H  R  SF    L      +A  ++ FV      N  IQ+ +   +GG    
Sbjct: 269 YMEEVRRQHMERCTSFLVDELGVVDRSQAGDRIFFVSAKEVLNARIQKAQGMPEGG---- 324

Query: 355 YDIVTIGAPAAHCQGFKSGGLRKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEI 414
                         G  + G + ++ +F+  ++ FEEC + S  ++     Q  VRAK+I
Sbjct: 325 --------------GALAEGFQVRMFEFQNFERRFEECISQSAVKT--KFEQHTVRAKQI 368

Query: 415 IAQINTLKTQV-------SYYAERLSRAAKDRSATGLERTLAILA 452
              +  +   +         Y E +    +DR    +++ L +LA
Sbjct: 369 AEAVRLIMDSLHMAAREQQVYCEEMREERQDR-LKFIDKQLELLA 412


>gi|23510377 KN motif and ankyrin repeat domains 1 isoform b [Homo
           sapiens]
          Length = 1194

 Score = 31.6 bits (70), Expect = 3.6
 Identities = 31/141 (21%), Positives = 59/141 (41%), Gaps = 17/141 (12%)

Query: 421 LKTQVSYYAERLSRAAKD-RSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARP 479
           ++ Q++   +RL    +  R+   L+  +++L ++ RQLV+    +  A+ I+     + 
Sbjct: 105 IREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGVRKR 164

Query: 480 DYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLE 539
            Y A  AS    + EQ+               R S   L +D+ EEE E V  +  +  E
Sbjct: 165 SYSAGNAS----QLEQLS------------RARRSGGELYIDYEEEEMETVEQSTQRIKE 208

Query: 540 CIIQRVDKLLQKERLHGEGCE 560
                 D    ++++    CE
Sbjct: 209 FRQLTADMQALEQKIQDSSCE 229


>gi|64464726 KN motif and ankyrin repeat domains 1 isoform a [Homo
           sapiens]
          Length = 1352

 Score = 31.6 bits (70), Expect = 3.6
 Identities = 31/141 (21%), Positives = 59/141 (41%), Gaps = 17/141 (12%)

Query: 421 LKTQVSYYAERLSRAAKD-RSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARP 479
           ++ Q++   +RL    +  R+   L+  +++L ++ RQLV+    +  A+ I+     + 
Sbjct: 263 IREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGVRKR 322

Query: 480 DYIASKASPTSTEEEQVMLRNDQDTLMARWTGRNSRSSLQVDWHEEEWEKVWLNVDKSLE 539
            Y A  AS    + EQ+               R S   L +D+ EEE E V  +  +  E
Sbjct: 323 SYSAGNAS----QLEQLS------------RARRSGGELYIDYEEEEMETVEQSTQRIKE 366

Query: 540 CIIQRVDKLLQKERLHGEGCE 560
                 D    ++++    CE
Sbjct: 367 FRQLTADMQALEQKIQDSSCE 387


>gi|223278381 ribosomal RNA processing 12 homolog isoform 2 [Homo
            sapiens]
          Length = 1236

 Score = 30.4 bits (67), Expect = 8.1
 Identities = 31/143 (21%), Positives = 58/143 (40%), Gaps = 22/143 (15%)

Query: 43   EPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIA 102
            E +LE         T  + +    F+ V+VT    A   KH Q          + + +I 
Sbjct: 880  EQLLENVCLLLASRTRDVVKSALGFIKVAVTVMDVAHLAKHVQ----------LVMEAIG 929

Query: 103  FFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAES-- 160
               D +           + +K R+  T ++   G  +VK LL + +HR+ + +R AE+  
Sbjct: 930  KLSDDMRRH--------FRMKLRNLFTKFIRKFGFELVKRLLPEEYHRVLVNIRKAEARA 981

Query: 161  --DRVGNITVIGWQMEEKSDQRP 181
               R  +   +  + EE+ ++ P
Sbjct: 982  KRHRALSQAAVEEEEEEEEEEEP 1004


>gi|223278379 ribosomal RNA processing 12 homolog isoform 1 [Homo
            sapiens]
          Length = 1297

 Score = 30.4 bits (67), Expect = 8.1
 Identities = 31/143 (21%), Positives = 58/143 (40%), Gaps = 22/143 (15%)

Query: 43   EPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIA 102
            E +LE         T  + +    F+ V+VT    A   KH Q          + + +I 
Sbjct: 941  EQLLENVCLLLASRTRDVVKSALGFIKVAVTVMDVAHLAKHVQ----------LVMEAIG 990

Query: 103  FFQDSLINQMTQVKLSVYDVKDRSQGTMYLLGSGTFIVKDLLQDRHHRLHLTLRSAES-- 160
               D +           + +K R+  T ++   G  +VK LL + +HR+ + +R AE+  
Sbjct: 991  KLSDDMRRH--------FRMKLRNLFTKFIRKFGFELVKRLLPEEYHRVLVNIRKAEARA 1042

Query: 161  --DRVGNITVIGWQMEEKSDQRP 181
               R  +   +  + EE+ ++ P
Sbjct: 1043 KRHRALSQAAVEEEEEEEEEEEP 1065


>gi|5730102 transient receptor potential cation channel, subfamily
           C, member 6 [Homo sapiens]
          Length = 931

 Score = 30.4 bits (67), Expect = 8.1
 Identities = 44/195 (22%), Positives = 78/195 (40%), Gaps = 19/195 (9%)

Query: 329 KKLEFVPTNLHIQR--MRVQDDGGSDQNYDIVTIGAPAAHCQGFKSGGLRKKLHKFEETK 386
           K+L   P+   +Q+      D+ G+  ++D+  I   AAHCQ ++   +   L K    +
Sbjct: 190 KRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPI-ILAAHCQEYEI--VHTLLRKGARIE 246

Query: 387 KHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLER 446
           +  +  C  + C       Q         ++IN  K   S     LS      +A  L  
Sbjct: 247 RPHDYFCKCNDCNQ----KQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSN 302

Query: 447 TLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPT-STEEEQVMLRNDQDTL 505
            LA+LA+  ++           N    L+    D++        +TEE + +L  D +TL
Sbjct: 303 ELAVLANIEKEF---------KNDYKKLSMQCKDFVVGLLDLCRNTEEVEAILNGDVETL 353

Query: 506 MARWTGRNSRSSLQV 520
            +   GR + S L++
Sbjct: 354 QSGDHGRPNLSRLKL 368


>gi|157676340 zinc finger protein 142 [Homo sapiens]
          Length = 1687

 Score = 30.4 bits (67), Expect = 8.1
 Identities = 13/35 (37%), Positives = 21/35 (60%)

Query: 42  DEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPP 76
           + P+LE  ++    + PSL+  PN++V    TTPP
Sbjct: 754 ENPLLEKPVSEPSTNPPSLEEAPNNWVGTFKTTPP 788


>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
           sapiens]
          Length = 1133

 Score = 30.4 bits (67), Expect = 8.1
 Identities = 46/197 (23%), Positives = 80/197 (40%), Gaps = 30/197 (15%)

Query: 376 RKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRA 435
           R+ + + EE K+  +E    S  + I  + Q+  R K++I Q   +K+Q     E+  R 
Sbjct: 169 RQTILELEEEKRKHKEYMEKSD-EFICLLEQECERLKKLIDQ--EIKSQEEKEQEKEKRV 225

Query: 436 AKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGL--NAARPDYIASKASPTSTEE 493
              +      ++ A++    +Q +T     L    I  L  NA       + A     EE
Sbjct: 226 TTLKEELTKLKSFALMVVDEQQRLTA-QLTLQRQKIQELTTNAKETHTKLALAEARVQEE 284

Query: 494 EQVMLR-------------NDQDTLMARWTGRNSRS----------SLQVDWHEEEWEKV 530
           EQ   R              DQDT+MA+ T  +S++          S Q+D   EE  + 
Sbjct: 285 EQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQID-ELEETNRS 343

Query: 531 WLNVDKSLECIIQRVDK 547
               ++ L+ I +++ K
Sbjct: 344 LRKAEEELQDIKEKISK 360


>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
           sapiens]
          Length = 1135

 Score = 30.4 bits (67), Expect = 8.1
 Identities = 46/197 (23%), Positives = 80/197 (40%), Gaps = 30/197 (15%)

Query: 376 RKKLHKFEETKKHFEECCTSSGCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRA 435
           R+ + + EE K+  +E    S  + I  + Q+  R K++I Q   +K+Q     E+  R 
Sbjct: 169 RQTILELEEEKRKHKEYMEKSD-EFICLLEQECERLKKLIDQ--EIKSQEEKEQEKEKRV 225

Query: 436 AKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGL--NAARPDYIASKASPTSTEE 493
              +      ++ A++    +Q +T     L    I  L  NA       + A     EE
Sbjct: 226 TTLKEELTKLKSFALMVVDEQQRLTA-QLTLQRQKIQELTTNAKETHTKLALAEARVQEE 284

Query: 494 EQVMLR-------------NDQDTLMARWTGRNSRS----------SLQVDWHEEEWEKV 530
           EQ   R              DQDT+MA+ T  +S++          S Q+D   EE  + 
Sbjct: 285 EQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQID-ELEETNRS 343

Query: 531 WLNVDKSLECIIQRVDK 547
               ++ L+ I +++ K
Sbjct: 344 LRKAEEELQDIKEKISK 360


>gi|16933559 protocadherin LKC precursor [Homo sapiens]
          Length = 1310

 Score = 30.4 bits (67), Expect = 8.1
 Identities = 25/99 (25%), Positives = 37/99 (37%), Gaps = 10/99 (10%)

Query: 413  EIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIH 472
            E    +N      SY +       K+      +   A L   TR  V + D +     I 
Sbjct: 1033 EATTTLNLFTVDQSYRSRLQFSTPKEEVGANRQAINAALTQATRTTVYIVDIQ----DID 1088

Query: 473  GLNAARPD------YIASKASPTSTEEEQVMLRNDQDTL 505
                ARP       ++    S  + +E  VM+RNDQD+L
Sbjct: 1089 SAARARPHSYLDAYFVFPNGSALTLDELSVMIRNDQDSL 1127


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,464,856
Number of Sequences: 37866
Number of extensions: 1485644
Number of successful extensions: 3953
Number of sequences better than 10.0: 29
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 3919
Number of HSP's gapped (non-prelim): 35
length of query: 938
length of database: 18,247,518
effective HSP length: 112
effective length of query: 826
effective length of database: 14,006,526
effective search space: 11569390476
effective search space used: 11569390476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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