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Search of human proteins with 47519490
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47519490 reticulon 4 isoform D [Homo sapiens]
(392 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47519490 reticulon 4 isoform D [Homo sapiens] 775 0.0
gi|24431933 reticulon 4 isoform B [Homo sapiens] 729 0.0
gi|24431935 reticulon 4 isoform A [Homo sapiens] 418 e-117
gi|47519562 reticulon 4 isoform E [Homo sapiens] 364 e-101
gi|5902016 reticulon 4 isoform C [Homo sapiens] 361 e-100
gi|10863935 reticulon 1 isoform A [Homo sapiens] 286 3e-77
gi|45827778 reticulon 1 isoform B [Homo sapiens] 282 4e-76
gi|45827776 reticulon 1 isoform C [Homo sapiens] 268 6e-72
gi|41393604 reticulon 3 isoform c [Homo sapiens] 254 1e-67
gi|5174655 reticulon 3 isoform a [Homo sapiens] 250 1e-66
gi|41393608 reticulon 3 isoform b [Homo sapiens] 244 7e-65
gi|41393606 reticulon 3 isoform d [Homo sapiens] 214 1e-55
gi|46255005 reticulon 2 isoform B [Homo sapiens] 198 8e-51
gi|5032055 reticulon 2 isoform A [Homo sapiens] 192 3e-49
gi|46255007 reticulon 2 isoform C [Homo sapiens] 187 1e-47
gi|153792074 proline rich 12 [Homo sapiens] 78 2e-14
gi|33356148 formin-like 1 [Homo sapiens] 68 1e-11
gi|210032580 SET domain containing 1B [Homo sapiens] 65 8e-11
gi|47132519 Ras association and pleckstrin homology domains 1 is... 65 1e-10
gi|7706501 WW domain binding protein 11 [Homo sapiens] 65 1e-10
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 64 2e-10
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 64 2e-10
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 64 3e-10
gi|55741677 SET domain containing 1A [Homo sapiens] 62 1e-09
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 62 1e-09
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 62 1e-09
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 62 1e-09
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 62 1e-09
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s... 62 1e-09
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 61 2e-09
>gi|47519490 reticulon 4 isoform D [Homo sapiens]
Length = 392
Score = 775 bits (2001), Expect = 0.0
Identities = 392/392 (100%), Positives = 392/392 (100%)
Query: 1 MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPA 60
MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPA
Sbjct: 1 MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPA 60
Query: 61 AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAP 120
AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAP
Sbjct: 61 AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAP 120
Query: 121 SPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRG 180
SPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRG
Sbjct: 121 SPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRG 180
Query: 181 SSGSVDETLFALPAASEPVIRSSAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT 240
SSGSVDETLFALPAASEPVIRSSAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT
Sbjct: 181 SSGSVDETLFALPAASEPVIRSSAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT 240
Query: 241 AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVN 300
AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVN
Sbjct: 241 AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVN 300
Query: 301 CTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQA 360
CTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQA
Sbjct: 301 CTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQA 360
Query: 361 QIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE 392
QIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE
Sbjct: 361 QIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE 392
>gi|24431933 reticulon 4 isoform B [Homo sapiens]
Length = 373
Score = 729 bits (1881), Expect = 0.0
Identities = 373/392 (95%), Positives = 373/392 (95%), Gaps = 19/392 (4%)
Query: 1 MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPA 60
MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPA
Sbjct: 1 MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPA 60
Query: 61 AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAP 120
AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAP
Sbjct: 61 AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAP 120
Query: 121 SPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRG 180
SPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRG
Sbjct: 121 SPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRG 180
Query: 181 SSGSVDETLFALPAASEPVIRSSAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT 240
SSGSV VVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT
Sbjct: 181 SSGSV-------------------VVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVT 221
Query: 241 AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVN 300
AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVN
Sbjct: 222 AYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVN 281
Query: 301 CTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQA 360
CTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQA
Sbjct: 282 CTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQA 341
Query: 361 QIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE 392
QIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE
Sbjct: 342 QIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE 373
>gi|24431935 reticulon 4 isoform A [Homo sapiens]
Length = 1192
Score = 418 bits (1074), Expect = e-117
Identities = 204/204 (100%), Positives = 204/204 (100%)
Query: 1 MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPA 60
MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPA
Sbjct: 1 MEDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPA 60
Query: 61 AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAP 120
AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAP
Sbjct: 61 AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAP 120
Query: 121 SPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRG 180
SPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRG
Sbjct: 121 SPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRG 180
Query: 181 SSGSVDETLFALPAASEPVIRSSA 204
SSGSVDETLFALPAASEPVIRSSA
Sbjct: 181 SSGSVDETLFALPAASEPVIRSSA 204
Score = 364 bits (935), Expect = e-101
Identities = 199/250 (79%), Positives = 210/250 (84%), Gaps = 11/250 (4%)
Query: 145 PPPPASVSPQAE--PVWTPPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRS 202
PP ++++ QAE + P A P+ ++ S S A +
Sbjct: 952 PPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPS---------AIFSAELSK 1002
Query: 203 SAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ 262
++VVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ
Sbjct: 1003 TSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ 1062
Query: 263 AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA 322
AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA
Sbjct: 1063 AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA 1122
Query: 323 VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA 382
VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA
Sbjct: 1123 VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA 1182
Query: 383 KIPGLKRKAE 392
KIPGLKRKAE
Sbjct: 1183 KIPGLKRKAE 1192
>gi|47519562 reticulon 4 isoform E [Homo sapiens]
Length = 986
Score = 364 bits (935), Expect = e-101
Identities = 199/250 (79%), Positives = 210/250 (84%), Gaps = 11/250 (4%)
Query: 145 PPPPASVSPQAE--PVWTPPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRS 202
PP ++++ QAE + P A P+ ++ S S A +
Sbjct: 746 PPDVSALATQAEIESIVKPKVLVKEAEKKLPSDTEKEDRSPS---------AIFSAELSK 796
Query: 203 SAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ 262
++VVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ
Sbjct: 797 TSVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ 856
Query: 263 AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA 322
AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA
Sbjct: 857 AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA 916
Query: 323 VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA 382
VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA
Sbjct: 917 VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA 976
Query: 383 KIPGLKRKAE 392
KIPGLKRKAE
Sbjct: 977 KIPGLKRKAE 986
>gi|5902016 reticulon 4 isoform C [Homo sapiens]
Length = 199
Score = 361 bits (927), Expect = e-100
Identities = 188/188 (100%), Positives = 188/188 (100%)
Query: 205 VVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAI 264
VVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAI
Sbjct: 12 VVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAI 71
Query: 265 QKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVL 324
QKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVL
Sbjct: 72 QKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVL 131
Query: 325 MWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKI 384
MWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKI
Sbjct: 132 MWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKI 191
Query: 385 PGLKRKAE 392
PGLKRKAE
Sbjct: 192 PGLKRKAE 199
>gi|10863935 reticulon 1 isoform A [Homo sapiens]
Length = 776
Score = 286 bits (731), Expect = 3e-77
Identities = 182/429 (42%), Positives = 237/429 (55%), Gaps = 72/429 (16%)
Query: 4 LDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGL 63
L P V + PP + P D E E + E +E++ P A
Sbjct: 380 LADRPEVKARSGPPT---------IPSPLDHEASSAESGDSE------IELVSEDPMAAE 424
Query: 64 SAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVA-----PERQPSWDPSPVSSTVP 118
A P + + FG+ PP P PA+P + ER+ D + +
Sbjct: 425 DALP--------SGYVSFGHVGGPP----PSPASPSIQYSILREEREAELDSELIIESCD 472
Query: 119 APSPLSAAAVSPSKLPEDDEPPARPPP-------------PPPASVSPQAEP------VW 159
A S A+ SP + E D PP +P S AEP
Sbjct: 473 ASS---ASEESPKR--EQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPS 527
Query: 160 TPPAPAPAAPPS-------TPAAPKRRGSSGSVDETLFAL-------PAASEPVI--RSS 203
T P P P PP TP P++ S +++ A P A P++
Sbjct: 528 TEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQ 587
Query: 204 AVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQA 263
+DLLYWRDIK+TG+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK V+QA
Sbjct: 588 KAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQA 647
Query: 264 IQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAV 323
+QK+DEGHPF+AYLE E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSLKFAV
Sbjct: 648 VQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAV 707
Query: 324 LMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAK 383
LMW+ TYVGALFNGLTLL++A++S+F++PV+Y +HQAQID YLGL ++ +AKIQAK
Sbjct: 708 LMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAK 767
Query: 384 IPGLKRKAE 392
IPG KR AE
Sbjct: 768 IPGAKRHAE 776
Score = 35.0 bits (79), Expect = 0.12
Identities = 46/181 (25%), Positives = 72/181 (39%), Gaps = 17/181 (9%)
Query: 22 AFKYQFVREPEDEEEEEEEEEEDEDEDLE---ELEVLERKPAAGLSAAPVPTAPAAGAPL 78
A+KY + PE+ + +E+ E ED+DL+ + + KP P AP G +
Sbjct: 193 AYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEG--VREPDKPAPVEGKII 250
Query: 79 MDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDE 138
D + AP +R+ +PV T+ P S + K PE +
Sbjct: 251 KDHLLEESTFAPY----IDDLSEEQRRAPQITTPVKITLTEIEP-SVETTTQEKTPEKQD 305
Query: 139 PPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSG----SVDETLFALPA 194
+P P +V+ +EP +P PPS+ P S G S DE + A+
Sbjct: 306 ICLKPSPDTVPTVT-VSEP--EDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAIKE 362
Query: 195 A 195
A
Sbjct: 363 A 363
>gi|45827778 reticulon 1 isoform B [Homo sapiens]
Length = 356
Score = 282 bits (721), Expect = 4e-76
Identities = 163/341 (47%), Positives = 209/341 (61%), Gaps = 40/341 (11%)
Query: 87 PPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPP- 145
PP+P P + ER+ D + + A S A+ SP + E D PP +P
Sbjct: 21 PPSPASPSIQYSILREEREAELDSELIIESCDASS---ASEESPKR--EQDSPPMKPSAL 75
Query: 146 ------------PPPASVSPQAEP------VWTPPAPAPAAPPS-------TPAAPKRRG 180
S AEP T P P P PP TP P++
Sbjct: 76 DAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPE 135
Query: 181 SSGSVDETLFAL-------PAASEPVI--RSSAVVDLLYWRDIKKTGVVFGASLFLLLSL 231
S +++ A P A P++ +DLLYWRDIK+TG+VFG+ L LL SL
Sbjct: 136 EDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSL 195
Query: 232 TVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKY 291
T FS+VSV AY+ALA LS TISFRIYK V+QA+QK+DEGHPF+AYLE E+ +S+E +QKY
Sbjct: 196 TQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKY 255
Query: 292 SNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSV 351
++ +VN T+KELRRLFLV DLVDSLKFAVLMW+ TYVGALFNGLTLL++A++S+F++
Sbjct: 256 TDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTL 315
Query: 352 PVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGLKRKAE 392
PV+Y +HQAQID YLGL ++ +AKIQAKIPG KR AE
Sbjct: 316 PVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE 356
>gi|45827776 reticulon 1 isoform C [Homo sapiens]
Length = 208
Score = 268 bits (685), Expect = 6e-72
Identities = 129/190 (67%), Positives = 160/190 (84%)
Query: 203 SAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ 262
S +DLLYWRDIK+TG+VFG+ L LL SLT FS+VSV AY+ALA LS TISFRIYK V+Q
Sbjct: 19 SQAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQ 78
Query: 263 AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA 322
A+QK+DEGHPF+AYLE E+ +S+E +QKY++ +VN T+KELRRLFLV DLVDSLKFA
Sbjct: 79 AVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFA 138
Query: 323 VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA 382
VLMW+ TYVGALFNGLTLL++A++S+F++PV+Y +HQAQID YLGL ++ +AKIQA
Sbjct: 139 VLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQA 198
Query: 383 KIPGLKRKAE 392
KIPG KR AE
Sbjct: 199 KIPGAKRHAE 208
>gi|41393604 reticulon 3 isoform c [Homo sapiens]
Length = 255
Score = 254 bits (648), Expect = 1e-67
Identities = 129/236 (54%), Positives = 172/236 (72%), Gaps = 6/236 (2%)
Query: 161 PPAPAPAAPPST-PAAPKRRGSSGSVDETLFALPAASEPV--IRSSAVVDLLYWRDIKKT 217
P AP P PA + SS D F ++S+PV +S V DL++WRD+KKT
Sbjct: 22 PSAPGGGGSPGACPALGTKSCSSSCADS--FVSSSSSQPVSLFSTSQVHDLIFWRDVKKT 79
Query: 218 GVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYL 277
G VFG +L +LLSL FS++SV +Y+ LALLSVTISFRIYK VIQA+QKS+EGHPF+AYL
Sbjct: 80 GFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYL 139
Query: 278 ESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNG 337
+ ++ +S E Y N+A+ H+N +K + RLFLV+DLVDSLK AV MW+ TYVGA+FNG
Sbjct: 140 DVDITLSSEAFHNYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNG 199
Query: 338 LTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGL-KRKAE 392
+TLLILA + +FSVP++YE+++ QIDHY+G+A K + KIQAK+PG+ K+KAE
Sbjct: 200 ITLLILAELLIFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE 255
>gi|5174655 reticulon 3 isoform a [Homo sapiens]
Length = 236
Score = 250 bits (639), Expect = 1e-66
Identities = 127/222 (57%), Positives = 166/222 (74%), Gaps = 9/222 (4%)
Query: 173 PAAPKRRGSSGSVDETLFALPAASEPVIRSS-AVVDLLYWRDIKKTGVVFGASLFLLLSL 231
P+AP GS G A PA SS AV DL++WRD+KKTG VFG +L +LLSL
Sbjct: 22 PSAPGGGGSPG-------ACPALGTKSCSSSCAVHDLIFWRDVKKTGFVFGTTLIMLLSL 74
Query: 232 TVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKY 291
FS++SV +Y+ LALLSVTISFRIYK VIQA+QKS+EGHPF+AYL+ ++ +S E Y
Sbjct: 75 AAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNY 134
Query: 292 SNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSV 351
N+A+ H+N +K + RLFLV+DLVDSLK AV MW+ TYVGA+FNG+TLLILA + +FSV
Sbjct: 135 MNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFSV 194
Query: 352 PVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGL-KRKAE 392
P++YE+++ QIDHY+G+A K + KIQAK+PG+ K+KAE
Sbjct: 195 PIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE 236
>gi|41393608 reticulon 3 isoform b [Homo sapiens]
Length = 1013
Score = 244 bits (624), Expect = 7e-65
Identities = 120/224 (53%), Positives = 164/224 (73%), Gaps = 1/224 (0%)
Query: 170 PSTPAAPKRRGSSGSVDETLFALPAASEPVIRSSAVVDLLYWRDIKKTGVVFGASLFLLL 229
P T R + S+ +T ++ +V DL++WRD+KKTG VFG +L +LL
Sbjct: 790 PITIRETTRVDAVSSLSKTELVKKHVLARLLTDFSVHDLIFWRDVKKTGFVFGTTLIMLL 849
Query: 230 SLTVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQ 289
SL FS++SV +Y+ LALLSVTISFRIYK VIQA+QKS+EGHPF+AYL+ ++ +S E
Sbjct: 850 SLAAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFH 909
Query: 290 KYSNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLF 349
Y N+A+ H+N +K + RLFLV+DLVDSLK AV MW+ TYVGA+FNG+TLLILA + +F
Sbjct: 910 NYMNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIF 969
Query: 350 SVPVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPGL-KRKAE 392
SVP++YE+++ QIDHY+G+A K + KIQAK+PG+ K+KAE
Sbjct: 970 SVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE 1013
>gi|41393606 reticulon 3 isoform d [Homo sapiens]
Length = 241
Score = 214 bits (544), Expect = 1e-55
Identities = 108/188 (57%), Positives = 141/188 (75%), Gaps = 8/188 (4%)
Query: 173 PAAPKRRGSSGSVDETLFALPAASEPVIRSS-AVVDLLYWRDIKKTGVVFGASLFLLLSL 231
P+AP GS G A PA SS AV DL++WRD+KKTG VFG +L +LLSL
Sbjct: 22 PSAPGGGGSPG-------ACPALGTKSCSSSCAVHDLIFWRDVKKTGFVFGTTLIMLLSL 74
Query: 232 TVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKY 291
FS++SV +Y+ LALLSVTISFRIYK VIQA+QKS+EGHPF+AYL+ ++ +S E Y
Sbjct: 75 AAFSVISVVSYLILALLSVTISFRIYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHNY 134
Query: 292 SNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSV 351
N+A+ H+N +K + RLFLV+DLVDSLK AV MW+ TYVGA+FNG+TLLILA + +FSV
Sbjct: 135 MNAAMVHINRALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLIFSV 194
Query: 352 PVIYERHQ 359
P++YE+++
Sbjct: 195 PIVYEKYK 202
>gi|46255005 reticulon 2 isoform B [Homo sapiens]
Length = 472
Score = 198 bits (503), Expect = 8e-51
Identities = 138/395 (34%), Positives = 194/395 (49%), Gaps = 52/395 (13%)
Query: 17 PRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGA 76
PRPQ + V EP D+ + + LE + L + P G P TAP +
Sbjct: 86 PRPQG----RSVSEPRDQHPQPSL-----GDSLESIPSLSQSPEPGRRGDP-DTAPPSER 135
Query: 77 PLMDFGN--DFVPPAPRG-------------PLPAAPPVAPERQPSWDPSP-VSSTVPAP 120
PL D D + RG PL P P R + + + +
Sbjct: 136 PLEDLRLRLDHLGWVARGTGSGEDSSTSSSTPLEDEEPQEPNRLETGEAGEELDLRLRLA 195
Query: 121 SPLSAAAVSPSKLPEDDEPPARPPPP---------PPASVSPQAEPVWTPPAPAPAAPPS 171
P S ++P P P A P P P + + E W P
Sbjct: 196 QPSSPEVLTPQLSPGSGTPQAGTPSPSRSRDSNSGPEEPLLEEEEKQWGP---------- 245
Query: 172 TPAAPKRRGSSGSVDETLFALPAASEPVIRSSAVVDLLYWRDIKKTGVVFGASLFLLLSL 231
P R S D+ F + EP + V DLLYW+D + +GVVF + LL L
Sbjct: 246 LEREPVRGQCLDSTDQLEFTV----EPRL---LVADLLYWKDTRTSGVVFTGLMVSLLCL 298
Query: 232 TVFSIVSVTAYIALALLSVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKY 291
FSIVSV A++AL LL TIS R+Y+ V+QA+ + D +PF+AYL+ ++ ++ E ++
Sbjct: 299 LHFSIVSVAAHLALLLLCGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERL 358
Query: 292 SNSALGHVNCTIKELRRLFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSV 351
S+ V +LR FLV+DLVDSLK A+L ++ T+VGA+FNGLTLLIL +I LF++
Sbjct: 359 SHQITSRVVSAATQLRHFFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTI 418
Query: 352 PVIYERHQAQIDHYLGLANKNVKDAMAKIQAKIPG 386
P++Y +HQAQID Y+GL + AKI+AKIPG
Sbjct: 419 PLLYRQHQAQIDQYVGLVTNQLSHIKAKIRAKIPG 453
>gi|5032055 reticulon 2 isoform A [Homo sapiens]
Length = 545
Score = 192 bits (489), Expect = 3e-49
Identities = 137/378 (36%), Positives = 192/378 (50%), Gaps = 40/378 (10%)
Query: 31 PEDEEEEEEEEEEDEDEDLEELEVLER--KPAAGL----SAAPVPTAPAAGAPLMDFGND 84
P ++EE +E + E EEL++ R +P++ +P P AG P D
Sbjct: 167 PLEDEEPQEPNRLETGEAGEELDLRLRLAQPSSPEVLTPQLSPGSGTPQAGTPSPSRSRD 226
Query: 85 FVPPAPRGPLPAAPPVAPERQPSWDP---SPVSSTVPAPSPLSAAAVSPSKLPEDDE--- 138
+ GP P+ E + W P PV + V P L E
Sbjct: 227 ----SNSGP---EEPLLEEEEKQWGPLEREPVRGQCLDSTDQLEFTVEPRLLGTAMEWLK 279
Query: 139 ---PPARPPPPPPASVSPQAEPVWTPPAPAPAAP-PSTPAA------PKRRGSSGSVDET 188
A P +SP P+WT P P TP K SSG
Sbjct: 280 TSLLLAVYKTVPILELSP---PLWTAIGWVQRGPTPPTPVLRVLLKWAKSPRSSG----- 331
Query: 189 LFALPAASEPVIRSSAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALL 248
+P+ S S V DLLYW+D + +GVVF + LL L FSIVSV A++AL LL
Sbjct: 332 ---VPSLSLGADMGSKVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLL 388
Query: 249 SVTISFRIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRR 308
TIS R+Y+ V+QA+ + D +PF+AYL+ ++ ++ E ++ S+ V +LR
Sbjct: 389 CGTISLRVYRKVLQAVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRH 448
Query: 309 LFLVDDLVDSLKFAVLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGL 368
FLV+DLVDSLK A+L ++ T+VGA+FNGLTLLIL +I LF++P++Y +HQAQID Y+GL
Sbjct: 449 FFLVEDLVDSLKLALLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGL 508
Query: 369 ANKNVKDAMAKIQAKIPG 386
+ AKI+AKIPG
Sbjct: 509 VTNQLSHIKAKIRAKIPG 526
>gi|46255007 reticulon 2 isoform C [Homo sapiens]
Length = 205
Score = 187 bits (476), Expect = 1e-47
Identities = 92/184 (50%), Positives = 129/184 (70%)
Query: 203 SAVVDLLYWRDIKKTGVVFGASLFLLLSLTVFSIVSVTAYIALALLSVTISFRIYKGVIQ 262
S V DLLYW+D + +GVVF + LL L FSIVSV A++AL LL TIS R+Y+ V+Q
Sbjct: 3 SKVADLLYWKDTRTSGVVFTGLMVSLLCLLHFSIVSVAAHLALLLLCGTISLRVYRKVLQ 62
Query: 263 AIQKSDEGHPFRAYLESEVAISEELVQKYSNSALGHVNCTIKELRRLFLVDDLVDSLKFA 322
A+ + D +PF+AYL+ ++ ++ E ++ S+ V +LR FLV+DLVDSLK A
Sbjct: 63 AVHRGDGANPFQAYLDVDLTLTREQTERLSHQITSRVVSAATQLRHFFLVEDLVDSLKLA 122
Query: 323 VLMWVFTYVGALFNGLTLLILALISLFSVPVIYERHQAQIDHYLGLANKNVKDAMAKIQA 382
+L ++ T+VGA+FNGLTLLIL +I LF++P++Y +HQAQID Y+GL + AKI+A
Sbjct: 123 LLFYILTFVGAIFNGLTLLILGVIGLFTIPLLYRQHQAQIDQYVGLVTNQLSHIKAKIRA 182
Query: 383 KIPG 386
KIPG
Sbjct: 183 KIPG 186
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 77.8 bits (190), Expect = 2e-14
Identities = 59/158 (37%), Positives = 68/158 (43%), Gaps = 26/158 (16%)
Query: 38 EEEEEEDEDEDLEE-----LEVLERKPAAGLSAAPVPT----APAA---------GAPLM 79
+EE+ ++ DL+E + L+ P AG P APAA G P
Sbjct: 1383 DEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLPSA 1442
Query: 80 DFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEP 139
+ PP P PP AP QP P P PSP A +PS P P
Sbjct: 1443 NSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPP----P 1498
Query: 140 PARPPPPPPASVSPQAEPVWTPPAPAP-AAPPSTPAAP 176
P PPPPPPA SP P PPA AP AAPP PAAP
Sbjct: 1499 PPLPPPPPPAMPSPPPPP---PPAAAPLAAPPEEPAAP 1533
Score = 43.1 bits (100), Expect = 4e-04
Identities = 43/141 (30%), Positives = 55/141 (39%), Gaps = 20/141 (14%)
Query: 61 AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPL-----PAAPPVAPERQPSWDPSPVSS 115
A L +P P P A + P P G L P P V P P PS V S
Sbjct: 758 AFLQKSPPPPPPTAQS---------TQPTPHGLLLEAGGPDLPLVLPPPPPQLLPS-VLS 807
Query: 116 TVPAPSPLSAAA----VSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPS 171
P+PSP ++ + P+ +PP PPPPPP + Q E PAAP
Sbjct: 808 HAPSPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPP-PMPLQLEAHLRSHGLEPAAPSP 866
Query: 172 TPAAPKRRGSSGSVDETLFAL 192
+ G++ E L AL
Sbjct: 867 RLRPEESLDPPGAMQELLGAL 887
Score = 42.0 bits (97), Expect = 0.001
Identities = 35/117 (29%), Positives = 46/117 (39%), Gaps = 5/117 (4%)
Query: 63 LSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAP--PVAPERQPSWDPSPVSSTVPAP 120
L + PT P++ G + PA GP P P P+ P P + A
Sbjct: 191 LKPSQAPTVPSSLGFERLAGGGVLGPAGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLAS 250
Query: 121 SPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPV---WTPPAPAPAAPPSTPA 174
S +AAA S + A P PPPP P+ + V + PA A PP PA
Sbjct: 251 SSAAAAAAEQSSPQLYNFSGAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPA 307
Score = 37.0 bits (84), Expect = 0.031
Identities = 18/61 (29%), Positives = 24/61 (39%)
Query: 118 PAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPK 177
P P S A +P PP + P PPP +P+ PP P P AP+
Sbjct: 1671 PVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPE 1730
Query: 178 R 178
+
Sbjct: 1731 K 1731
Score = 35.0 bits (79), Expect = 0.12
Identities = 38/147 (25%), Positives = 52/147 (35%), Gaps = 16/147 (10%)
Query: 62 GLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPS 121
G S P +A +A FG+ P P PP +P P V P+ +
Sbjct: 138 GSSTFPSSSALSAYQHPASFGSRPFP-VPSSLSLQDPPFSPPANGLLSPHDVLHLKPSQA 196
Query: 122 PL-----------SAAAVSPSKLPEDDEPPARP----PPPPPASVSPQAEPVWTPPAPAP 166
P + P+ L PP RP PPPPP + Q + + A A
Sbjct: 197 PTVPSSLGFERLAGGGVLGPAGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAA 256
Query: 167 AAPPSTPAAPKRRGSSGSVDETLFALP 193
AA S+P G++ ALP
Sbjct: 257 AAEQSSPQLYNFSGAAPGPPPPERALP 283
Score = 33.5 bits (75), Expect = 0.34
Identities = 27/84 (32%), Positives = 32/84 (38%), Gaps = 15/84 (17%)
Query: 87 PPAPRGPLPAAP------PVAPERQPSWDP-SPVSSTVPAPSPLSAAAVSPSKL------ 133
P A GP P P P P R P +P P P + V+ L
Sbjct: 974 PKAGAGPPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSG 1033
Query: 134 PEDDEPPARPPPPPPASVSPQAEP 157
P PP PPPPPP +P +EP
Sbjct: 1034 PHQAAPPPPPPPPPPP--APASEP 1055
Score = 32.3 bits (72), Expect = 0.76
Identities = 34/125 (27%), Positives = 43/125 (34%), Gaps = 23/125 (18%)
Query: 66 APVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPS-PLS 124
+P P+A G L++ PA R P PP P P P P+ S L
Sbjct: 811 SPSPSASKVGVHLLE-------PATRDGAPQPPPPPPPPPP---PMPLQLEAHLRSHGLE 860
Query: 125 AAAVSPSKLPEDD-EPPAR-----------PPPPPPASVSPQAEPVWTPPAPAPAAPPST 172
AA SP PE+ +PP PP P V P P + P
Sbjct: 861 PAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSPSPQG 920
Query: 173 PAAPK 177
AP+
Sbjct: 921 TKAPR 925
Score = 31.6 bits (70), Expect = 1.3
Identities = 21/61 (34%), Positives = 27/61 (44%), Gaps = 1/61 (1%)
Query: 66 APVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSA 125
AP P++P PL +P P P PAA P+A + PSP +P PL
Sbjct: 1490 APTPSSPPP-PPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDTRPLHL 1548
Query: 126 A 126
A
Sbjct: 1549 A 1549
Score = 31.6 bits (70), Expect = 1.3
Identities = 30/131 (22%), Positives = 45/131 (34%), Gaps = 7/131 (5%)
Query: 52 LEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDP- 110
+ V RKP PVP + A P P+ P P P PE+ S P
Sbjct: 1659 VRVCARKP---WHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPP 1715
Query: 111 --SPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAA 168
+P ++ P+P + + P + ++ E R P + P
Sbjct: 1716 EQTPETAMPEPPAPEKPSLLRPVEKEKEKEKVTRGERPLRGERATSGRQT-RPERSLATG 1774
Query: 169 PPSTPAAPKRR 179
P+T PK R
Sbjct: 1775 QPATSRLPKAR 1785
Score = 31.2 bits (69), Expect = 1.7
Identities = 32/121 (26%), Positives = 41/121 (33%), Gaps = 23/121 (19%)
Query: 75 GAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDP-SPVSSTVPAPSPLSAAAVSPSKL 133
G D+G P P A P P P++DP P P S A
Sbjct: 956 GGAADDYGKAGPPEDEGDPKAGAGP--PPGPPAYDPYGPY-----CPGRASGAG------ 1002
Query: 134 PEDDEPPARPPPPPPASVSPQAEPVW---------TPPAPAPAAPPSTPAAPKRRGSSGS 184
PE P PP + AEP+ PP P P PP PA+ + G +
Sbjct: 1003 PETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPPPAPASEPKGGLTSP 1062
Query: 185 V 185
+
Sbjct: 1063 I 1063
Score = 30.4 bits (67), Expect = 2.9
Identities = 34/124 (27%), Positives = 46/124 (37%), Gaps = 11/124 (8%)
Query: 72 PAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPS 131
P G P D + P G P P + + P + STV A PL P
Sbjct: 980 PPPGPPAYDPYGPYCPGRASGAGPETPGLGLDPNK---PPELPSTVNA-EPLGLIQSGPH 1035
Query: 132 KL-PEDDEPPARPPPPPPASVSPQ---AEPVWTPPAPAPAAPPSTPAAPKRRGSSGSVDE 187
+ P PP PPPP PAS P+ P++ P S+ +RR +
Sbjct: 1036 QAAPPPPPPP--PPPPAPAS-EPKGGLTSPIFCSTKPKKLLKTSSFHLLRRRDPPFQTPK 1092
Query: 188 TLFA 191
L+A
Sbjct: 1093 KLYA 1096
Score = 29.6 bits (65), Expect = 4.9
Identities = 26/87 (29%), Positives = 34/87 (39%), Gaps = 21/87 (24%)
Query: 59 PAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVP 118
P L + P AP +P +PP P +P+ PP P P
Sbjct: 1478 PQPALPSPPPLVAPTPSSP----PPPPLPPPPPPAMPSPPPPPP---------------P 1518
Query: 119 APSPLSAAAVSP-SKLPEDDE-PPARP 143
A +PL+A P + PED E P RP
Sbjct: 1519 AAAPLAAPPEEPAAPSPEDPELPDTRP 1545
>gi|33356148 formin-like 1 [Homo sapiens]
Length = 1100
Score = 68.2 bits (165), Expect = 1e-11
Identities = 75/243 (30%), Positives = 94/243 (38%), Gaps = 50/243 (20%)
Query: 2 EDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEED---------EDEDLEEL 52
E +S + +S PP P+ A R E + EE EE+ + +E L
Sbjct: 445 ERFSESTAMGASRRPPEPEKAPPAAPTRPSALELKVEELEEKGLIRILRGPGDAVSIEIL 504
Query: 53 EVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVP-----PAPRGPLPA------APPVA 101
V P+ G AP P P G+P D P P P PLP APP A
Sbjct: 505 PVAVATPSGG--DAPTPGVPT-GSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSA 561
Query: 102 PERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTP 161
P + P SP P P+P LP D PP PPPPPP + P P P
Sbjct: 562 PPQAPPLPGSPE----PPPAP---------PLPGDLPPPPPPPPPPPGTDGPVPPPP-PP 607
Query: 162 PAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRSSAVVDLLYWRDIKK---TG 218
P P P PP + G D L A +P I++ + LL W +K TG
Sbjct: 608 PPPPPGGPPD---------ALGRRDSELGPGVKAKKP-IQTKFRMPLLNWVALKPSQITG 657
Query: 219 VVF 221
VF
Sbjct: 658 TVF 660
>gi|210032580 SET domain containing 1B [Homo sapiens]
Length = 1923
Score = 65.5 bits (158), Expect = 8e-11
Identities = 78/254 (30%), Positives = 98/254 (38%), Gaps = 59/254 (23%)
Query: 2 EDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEE---EEEEEEEDEDEDLEELEVLERK 58
E + S SSS+S P EDEEE EEEEEE+E+E + E +
Sbjct: 1114 ESSESSEFESSSESSPSSS-----------EDEEEVVAREEEEEEEEEEMVAEESMASAG 1162
Query: 59 PAA----GLSAAPVPTAPAAGAPLM----DFGNDFVPPAPRGPLPAAPPV-------APE 103
P G AA P APA + M D + V P R + PP+ A
Sbjct: 1163 PEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADS 1222
Query: 104 RQPSWDPSP-------VSSTVPAPSPLSAAAVSPSKLPEDD-----EPPAR--------- 142
R+P +P +S PA + +SP + PE D EPP
Sbjct: 1223 REPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPL 1282
Query: 143 PPPPPPASVSPQAEPVWT-------PPAP-APAAPPSTPAAPKRRGSSGSVDETLFALPA 194
PPP PP SP EP T PP P A PP TP S S ET+ A P
Sbjct: 1283 PPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQST-ETVPATPG 1341
Query: 195 ASEPVIRSSAVVDL 208
P+ S+ + L
Sbjct: 1342 GEPPLSGGSSGLSL 1355
Score = 60.8 bits (146), Expect = 2e-09
Identities = 54/202 (26%), Positives = 74/202 (36%), Gaps = 53/202 (26%)
Query: 1 MEDLDQSPLVSSSDS-----------PPRPQP-------------AFKYQFVREPEDEEE 36
+ED+ +PL S + PP P P A R P E+
Sbjct: 569 LEDISPTPLPDSDEDEELDLGLGPRPPPEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKM 628
Query: 37 EEEEEEEDEDEDLEELEVLERKPAAGLSAA--PVPTAPAAGAPLMDFGNDFVPPAPRGPL 94
+E ++ ED ++ + E+ P+A +++A P P GA + + P P P
Sbjct: 629 DEGQQSSGEDMEISDDEM----PSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLPPP 684
Query: 95 PAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQ 154
P PP+ P P P P P PL P PPPPPPA +
Sbjct: 685 PGFPPLPPPPPPP----PPQPGFPMPPPL----------------PPPPPPPPPAHPAVT 724
Query: 155 AEPVWTPPAPAPAAPPSTPAAP 176
P PP PAP P P P
Sbjct: 725 VPP---PPLPAPPGVPPPPILP 743
Score = 39.7 bits (91), Expect = 0.005
Identities = 37/115 (32%), Positives = 46/115 (40%), Gaps = 12/115 (10%)
Query: 72 PAAGAPLMDFGNDFVP---PAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAV 128
PA P F + F P P P P P A + D S PAP PL A
Sbjct: 384 PAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARD-SGEFRRAPAPPPLPPA-- 440
Query: 129 SPSKLPEDDEPPARPPPPPPASVSPQAEPV--WTP-PAPAPAAP--PSTPAAPKR 178
P + PP PPPP S+ P W+P P +P P S+PA P++
Sbjct: 441 EPLAKEKPGTPPG-PPPPDTNSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEK 494
Score = 36.6 bits (83), Expect = 0.040
Identities = 28/77 (36%), Positives = 36/77 (46%), Gaps = 5/77 (6%)
Query: 93 PLPAAPPVAPERQPSWDP--SPVSSTVPAPS-PLSAAAVSPSKLPEDDEPPARPPPPPPA 149
P PA AP + ++ P +PV+ P P P + AA E PA PPP PPA
Sbjct: 382 PPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRAPA-PPPLPPA 440
Query: 150 SVSPQAEPVWTPPAPAP 166
+ +P TPP P P
Sbjct: 441 EPLAKEKP-GTPPGPPP 456
Score = 36.2 bits (82), Expect = 0.052
Identities = 29/96 (30%), Positives = 38/96 (39%), Gaps = 24/96 (25%)
Query: 75 GAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSW-DPSPVSSTVPAPSPLSAAAVSPSKL 133
G+P+ + P AP G QP + P+P SS PS +SP+ L
Sbjct: 530 GSPISSSSSQLSPLAPFGT---------NSQPGFRGPTPPSSR---PSSTGLEDISPTPL 577
Query: 134 PEDDE-----------PPARPPPPPPASVSPQAEPV 158
P+ DE PP P PP PA + Q V
Sbjct: 578 PDSDEDEELDLGLGPRPPPEPGPPDPAGLLSQTAEV 613
Score = 35.4 bits (80), Expect = 0.089
Identities = 44/143 (30%), Positives = 51/143 (35%), Gaps = 23/143 (16%)
Query: 66 APVPTAPAAGAPLMDFGNDF----VPPAPRGPL--PAAPPVAPERQPSWDP--SPVSSTV 117
AP P+ + G P G DF P GPL P P R P SPV
Sbjct: 1369 APSPSLSSGGLPRTP-GRDFSFTPTFSEPSGPLLLPVCPLPTGRRDERSGPLASPVLLET 1427
Query: 118 PAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPP---STPA 174
P PL P LP AR P P P + PAP + PP P
Sbjct: 1428 GLPLPLPLPLPLPLALPAVLRAQARAPTPLPPLL----------PAPLASCPPPMKRKPG 1477
Query: 175 APKRRGSSG-SVDETLFALPAAS 196
P+R S S+D L PA +
Sbjct: 1478 RPRRSPPSMLSLDGPLVRPPAGA 1500
Score = 34.7 bits (78), Expect = 0.15
Identities = 47/176 (26%), Positives = 67/176 (38%), Gaps = 14/176 (7%)
Query: 11 SSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDED--EDLEELEVLERKPAAGLSAAPV 68
S S QP Y F ++P + E + D E + PA ++A
Sbjct: 284 SQDSSYSSRQPTPSYLFSQDPAVTFKARRHESKFTDAYNRRHEHHYVHNSPA--VTAVAG 341
Query: 69 PTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAV 128
TA G+ + FG GP A P + P P +T P+P +A
Sbjct: 342 ATAAFRGSSDLPFGAVGGTGGSSGPPFKAQP-QDSATFAHTPPPAQAT---PAPGFKSAF 397
Query: 129 SPSKLPEDDEPPARPPPPPPASVSPQAEPVWT---PPAPAPAAPPSTPAAPKRRGS 181
SP + P PP PP P A+ + A PAP P PP+ P A ++ G+
Sbjct: 398 SPYQTPVAHFPP--PPEEPTATAAFGARDSGEFRRAPAPPPL-PPAEPLAKEKPGT 450
Score = 34.3 bits (77), Expect = 0.20
Identities = 14/27 (51%), Positives = 21/27 (77%)
Query: 30 EPEDEEEEEEEEEEDEDEDLEELEVLE 56
E E+E EEEEEEE+D+D+D ++ + E
Sbjct: 1049 EEEEEAEEEEEEEDDDDDDSDDRDESE 1075
Score = 32.7 bits (73), Expect = 0.58
Identities = 40/149 (26%), Positives = 45/149 (30%), Gaps = 40/149 (26%)
Query: 66 APVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSA 125
AP P P APL PP R P P R P PS +S P P +
Sbjct: 1453 APTPLPPLLPAPLASCP----PPMKR------KPGRPRRSP---PSMLSLDGPLVRPPAG 1499
Query: 126 AAVSPSKL-----------PEDDEP----------------PARPPPPPPASVSPQAEPV 158
AA+ L P +P P PP PPP P EP
Sbjct: 1500 AALGRELLLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPT 1559
Query: 159 WTPPAPAPAAPPSTPAAPKRRGSSGSVDE 187
P PS P RG +E
Sbjct: 1560 KLPFKELDNQWPSEAIPPGPRGRDEVTEE 1588
Score = 32.0 bits (71), Expect = 0.99
Identities = 13/20 (65%), Positives = 17/20 (85%)
Query: 29 REPEDEEEEEEEEEEDEDED 48
+E +EEEE EEEEE+ED+D
Sbjct: 1045 QESTEEEEEAEEEEEEEDDD 1064
Score = 30.8 bits (68), Expect = 2.2
Identities = 14/25 (56%), Positives = 16/25 (64%)
Query: 24 KYQFVREPEDEEEEEEEEEEDEDED 48
K E E EEEEE EEE+E+ED
Sbjct: 1038 KESLSEEQESTEEEEEAEEEEEEED 1062
Score = 30.4 bits (67), Expect = 2.9
Identities = 16/47 (34%), Positives = 27/47 (57%), Gaps = 2/47 (4%)
Query: 9 LVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDED--EDLEELE 53
L S + + + + + E E+ EEEEEEE++D+D +D +E E
Sbjct: 1029 LDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESE 1075
Score = 30.0 bits (66), Expect = 3.8
Identities = 18/66 (27%), Positives = 27/66 (40%)
Query: 134 PEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGSVDETLFALP 193
P+D A PPP A+ +P + ++P A P P P + G+ D F
Sbjct: 372 PQDSATFAHTPPPAQATPAPGFKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRA 431
Query: 194 AASEPV 199
A P+
Sbjct: 432 PAPPPL 437
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 65.1 bits (157), Expect = 1e-10
Identities = 45/129 (34%), Positives = 59/129 (45%), Gaps = 17/129 (13%)
Query: 59 PAAGLSAAPVPTAPAAGAPLMD-FGNDFVPPAP-RGPLPAAPPVAPERQPSWDPSPVSST 116
P +A P PT P A F ++PP+P P+P PP P++Q P S
Sbjct: 796 PVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPL 855
Query: 117 VPAPSPLSAAAVSPSKLPEDDEPPA---RPPPPPPASVSPQ------AEPVWTP---PAP 164
P PS + A S+ P PPA +P P PA+V+PQ A+P W P P P
Sbjct: 856 SPVPSVVKQIA---SQFPPPPTPPAMESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVP 912
Query: 165 APAAPPSTP 173
+P PP P
Sbjct: 913 SPDFPPPPP 921
Score = 53.1 bits (126), Expect = 4e-07
Identities = 38/116 (32%), Positives = 49/116 (42%), Gaps = 20/116 (17%)
Query: 67 PVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPS--PVSSTVPAPSPLS 124
P PT PA + + P P P +PP A + +P W PS PV S P P
Sbjct: 871 PPPTPPAMESQPLK-------PVPANVAPQSPP-AVKAKPKWQPSSIPVPSPDFPPPPPE 922
Query: 125 AAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTP-------PAPAPAAPPSTP 173
++ V P P P PPPPPP + SP + +P +P PP TP
Sbjct: 923 SSLVFP---PPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTP 975
Score = 50.8 bits (120), Expect = 2e-06
Identities = 48/162 (29%), Positives = 66/162 (40%), Gaps = 33/162 (20%)
Query: 59 PAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVP 118
P L P PT+ AP++ PP P P+P A ++QP++ P S P
Sbjct: 778 PPKPLVTIPAPTSTKTVAPVV---TQAAPPTPTPPVPPA-----KKQPAF---PASYIPP 826
Query: 119 APSPLSAAAVSPSKLPEDDEPPARPPPPPPAS--------VSPQAEPVWTPPA------- 163
+P P V P LP+ A+PPP P S ++ Q P TPPA
Sbjct: 827 SP-PTPPVPVPPPTLPKQQSFCAKPPPSP-LSPVPSVVKQIASQFPPPPTPPAMESQPLK 884
Query: 164 -----PAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVI 200
AP +PP+ A PK + SS V F P ++
Sbjct: 885 PVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLV 926
Score = 48.9 bits (115), Expect = 8e-06
Identities = 37/125 (29%), Positives = 48/125 (38%), Gaps = 21/125 (16%)
Query: 61 AGLSAAP-VPTAPAAGAP-------LMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSP 112
A L AP P+ P AP + PP P P P P+ P+ +P
Sbjct: 726 AQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQ-------AP 778
Query: 113 VSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAP----APAA 168
V P+P S V+P + PP PP PPA P + PP+P P
Sbjct: 779 PKPLVTIPAPTSTKTVAP--VVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVP 836
Query: 169 PPSTP 173
PP+ P
Sbjct: 837 PPTLP 841
Score = 42.0 bits (97), Expect = 0.001
Identities = 25/65 (38%), Positives = 31/65 (47%), Gaps = 3/65 (4%)
Query: 112 PVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPS 171
P +S VP SP V+P + P PPPPPP P P PP P+ +AP +
Sbjct: 601 PYTSLVPPLSP-QPKIVTPYTASQPSPP--LPPPPPPPPPPPPPPPPPPPPLPSQSAPSA 657
Query: 172 TPAAP 176
AAP
Sbjct: 658 GSAAP 662
Score = 41.6 bits (96), Expect = 0.001
Identities = 29/96 (30%), Positives = 37/96 (38%), Gaps = 6/96 (6%)
Query: 86 VPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPP 145
+PP P P P PP P P S S+ AP + + ++ + PP
Sbjct: 628 LPPPPPPPPPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPP 687
Query: 146 PPPA----SVSPQ--AEPVWTPPAPAPAAPPSTPAA 175
PP SV PQ P P P P PP TP +
Sbjct: 688 TPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGS 723
Score = 41.2 bits (95), Expect = 0.002
Identities = 32/95 (33%), Positives = 38/95 (40%), Gaps = 9/95 (9%)
Query: 87 PPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPP 146
PP P P P + + P P S P P + P P PPPP
Sbjct: 713 PPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAP----PTPPPPPP 768
Query: 147 PPASVSPQA--EPVWTPPAPA---PAAPPSTPAAP 176
PA + PQA +P+ T PAP AP T AAP
Sbjct: 769 IPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAP 803
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/145 (28%), Positives = 53/145 (36%), Gaps = 46/145 (31%)
Query: 55 LERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVS 114
++ KP S+ PVP+ DF PP P L PP PS P+P
Sbjct: 898 VKAKPKWQPSSIPVPSP------------DFPPPPPESSLVFPPP-----PPSPVPAPPP 940
Query: 115 STVPAPSPLSAAAVSP-SKLPEDDEPPARPPPPPP--------ASVSPQAEP-------- 157
P SP + SP K + P + PPP P +S + EP
Sbjct: 941 PPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPKRPSVDSL 1000
Query: 158 --VWTPPA----------PAPAAPP 170
+TPPA P PAAPP
Sbjct: 1001 VSKFTPPAESGSPSKETLPPPAAPP 1025
Score = 39.3 bits (90), Expect = 0.006
Identities = 32/109 (29%), Positives = 43/109 (39%), Gaps = 25/109 (22%)
Query: 87 PPAPRGPLPAAPPVAPERQPS-WDPSPVS---STV----------------PAPSPLSAA 126
PP P P P PP+ + PS +P+ ST+ P P + +
Sbjct: 636 PPPPPPPPPPPPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHSGALFKPPTPPVMQSQ 695
Query: 127 AVSPSKLPEDD----EPPARPPPPPPASVSPQAEPV-WTPPAPAPAAPP 170
+V P L + PP PPPP P S Q +P P P +APP
Sbjct: 696 SVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPP 744
Score = 31.6 bits (70), Expect = 1.3
Identities = 31/95 (32%), Positives = 41/95 (43%), Gaps = 9/95 (9%)
Query: 83 NDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPAR 142
+DF PP P LP PP+ S + SP + V P P + +S K P PP R
Sbjct: 1071 SDFPPPPPETELP-LPPIEIPAVFSGNTSPKVAVV-NPQPQQWSKMSVKKAP----PPTR 1124
Query: 143 PPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPK 177
P ++ QAE + P A P P +PK
Sbjct: 1125 PKRNDSTRLT-QAE-ISEQPTMATVV-PQVPTSPK 1156
Score = 30.4 bits (67), Expect = 2.9
Identities = 20/59 (33%), Positives = 31/59 (52%), Gaps = 9/59 (15%)
Query: 98 PPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPP-PASVSPQA 155
PP++P+ + +P +++ P+P PL P P PP PPPPP P+ +P A
Sbjct: 607 PPLSPQPKIV---TPYTASQPSP-PLPP----PPPPPPPPPPPPPPPPPPLPSQSAPSA 657
>gi|7706501 WW domain binding protein 11 [Homo sapiens]
Length = 641
Score = 64.7 bits (156), Expect = 1e-10
Identities = 51/161 (31%), Positives = 65/161 (40%), Gaps = 28/161 (17%)
Query: 31 PEDEEEEEEEEEEDEDEDLEELEV--------LERKPAAGLS-AAPVPTAPAAGAPLMDF 81
PE+ E EE E+D+++D ++ E E + G S A+ AP P
Sbjct: 343 PEEGREVEEFSEDDDEDDSDDSEAEKQSQKQHKEESHSDGTSTASSQQQAPPQSVPPSQI 402
Query: 82 GNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPA 141
PP P GP P PP AP +P P P + P P P + + P +P P
Sbjct: 403 Q---APPMP-GPPPLGPPPAPPLRP---PGPPTGLPPGPPPGAPPFLRPPGMPGLRGPLP 455
Query: 142 R--PPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRG 180
R PP PPP PP P P PP P P RG
Sbjct: 456 RLLPPGPPPGR----------PPGPPPGPPPGLPPGPPPRG 486
Score = 35.8 bits (81), Expect = 0.068
Identities = 35/119 (29%), Positives = 48/119 (40%), Gaps = 10/119 (8%)
Query: 39 EEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAP 98
E+E D ++L +LEV + A LS A + +P AP L
Sbjct: 97 EKENPDIYKELRKLEVEYEQKRAQLSQYFDAVKNAQHVEVESIPLPDMPHAPSNILIQDI 156
Query: 99 PVAPERQPSWDPSPVSSTVPAPSPLSAAAVSP------SKLPEDDEPPARPPPPPPASV 151
P+ P QP PS + T P A ++ P +LP +PP PP PPP V
Sbjct: 157 PL-PGAQP---PSILKKTSAYGPPTRAVSILPLLGHGVPRLPPGRKPPGPPPGPPPPQV 211
Score = 33.9 bits (76), Expect = 0.26
Identities = 44/174 (25%), Positives = 58/174 (33%), Gaps = 27/174 (15%)
Query: 59 PAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQ--------PSWDP 110
P G P P P P G P PR P PA P + P R P P
Sbjct: 462 PPPGRPPGPPPGPPPGLPP----GPPPRGPPPRLPPPAPPGIPPPRPGMMRPPLVPPLGP 517
Query: 111 SPVSSTVPAPSPLSAAAVSPSKLPE----DDEPPARPPPPPPASVSPQAEPVWTPPAPAP 166
+P PAP P +P L + DD A A++S + + + P A
Sbjct: 518 APPGLFPPAPLPNPGVLSAPPNLIQRPKADDTSAATIEKKATATISAKPQ-ITNPKAEIT 576
Query: 167 AAPPS----------TPAAPKRRGSSGSVDETLFALPAASEPVIRSSAVVDLLY 210
P+ AAP+R+ S A P + V S D +Y
Sbjct: 577 RFVPTALRVRRENKGATAAPQRKSEDDSAVPLAKAAPKSGPSVPVSVQTKDDVY 630
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 855
Score = 63.9 bits (154), Expect = 2e-10
Identities = 47/145 (32%), Positives = 62/145 (42%), Gaps = 27/145 (18%)
Query: 59 PAAGLSAAPVPTAPAA---------GAPLMDFGNDFVPPAPRGPLPAAPPVAP------- 102
P+A S +P+ PA G+P + + F+P P PL PP AP
Sbjct: 345 PSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP 404
Query: 103 -ERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPAS--VSPQAEPVW 159
+ PS SP S + PSP + A++ L PP PP P S SP P
Sbjct: 405 LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA 464
Query: 160 TPPAPAPAA--------PPSTPAAP 176
TPP+ AP + PPS PA+P
Sbjct: 465 TPPSQAPPSLAAPPLQVPPSPPASP 489
Score = 53.5 bits (127), Expect = 3e-07
Identities = 46/155 (29%), Positives = 64/155 (41%), Gaps = 13/155 (8%)
Query: 65 AAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLS 124
A P P AP A A + PP+P P +PP +P PS P + A PL
Sbjct: 421 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ 480
Query: 125 AAAVSPSKLPEDDEPPARPPP--PPP--------ASVSPQAEP-VWTPPAPAPAAPPSTP 173
P+ P P A PPP PPP A PQA P + TPP A +PP++
Sbjct: 481 VPPSPPASPPMS--PSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASF 538
Query: 174 AAPKRRGSSGSVDETLFALPAASEPVIRSSAVVDL 208
S S+ + A P P + ++ ++ +
Sbjct: 539 PGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQV 573
Score = 53.1 bits (126), Expect = 4e-07
Identities = 51/158 (32%), Positives = 67/158 (42%), Gaps = 25/158 (15%)
Query: 59 PAAG-LSAAPVPTAPAAGAPLMDFGNDFVPPAPRG---------PLPAAPPVAPERQPSW 108
PA G LS++P+ T P+ A L +P P PLP APP +P PS
Sbjct: 294 PALGPLSSSPLAT-PSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPP-SPSAPPSL 351
Query: 109 DPSPVSSTVPAPSPLSAAAVSP------SKLPEDDEPPARPPPP--PPASVSPQAEPVWT 160
P P PS + + SP S LP P PPP PPA P P+
Sbjct: 352 QTLPSPPATP-PSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP---PLQA 407
Query: 161 PPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEP 198
PP+P PA+PP +P A + ++ L P + P
Sbjct: 408 PPSP-PASPPLSPLATPSPQAPNALAVHLLQAPFSPPP 444
Score = 52.8 bits (125), Expect = 5e-07
Identities = 44/136 (32%), Positives = 55/136 (40%), Gaps = 26/136 (19%)
Query: 59 PAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVP 118
P A +P T P+ P + VPP+P A+PP++ PS P P +
Sbjct: 454 PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPP----ASPPMS----PSATPPPQAPPPL 505
Query: 119 APSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQA----------EPVWTPPAPAP-- 166
A PL A P P PP + P PPAS QA P+ TPP AP
Sbjct: 506 AAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV 565
Query: 167 ------AAPPSTPAAP 176
PPS PA+P
Sbjct: 566 LAAPLLQVPPSPPASP 581
Score = 51.6 bits (122), Expect = 1e-06
Identities = 55/196 (28%), Positives = 77/196 (39%), Gaps = 30/196 (15%)
Query: 17 PRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAG----------LSAA 66
PRP P+ + + P E + E E R+P+AG LS++
Sbjct: 190 PRPAPSARPR----PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSS 245
Query: 67 PVP-TAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSA 125
P ++PA P P AP P P +P P PA PLS+
Sbjct: 246 ATPLSSPARSGP----SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 301
Query: 126 ---AAVSPSKLPEDDEPPARPPPPPPASVSPQ-AEPVWTPPAPAPAAP------PSTPAA 175
A SPS + PP P P +S++ Q A P+ P P+P+AP PS PA
Sbjct: 302 SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAP-PSPSAPPSLQTLPSPPAT 360
Query: 176 PKRRGSSGSVDETLFA 191
P + ++ TL A
Sbjct: 361 PPSQATTSLGSPTLQA 376
Score = 47.4 bits (111), Expect = 2e-05
Identities = 46/150 (30%), Positives = 59/150 (39%), Gaps = 15/150 (10%)
Query: 63 LSAAP--VPTAPAAGAPLMDFGNDFVPPAPRGPLP-AAPPVAPERQPSWDPSPVSSTVPA 119
L+A P VP +P A P+ + P P+ P P AAPP+ + P P P +T P
Sbjct: 474 LAAPPLQVPPSPPASPPM----SPSATPPPQAPPPLAAPPLQLAKPPPQAP-PALATPPL 528
Query: 120 PSPLSAAAVSPSKLPEDDE------PPARPPPP-PPASVSPQAEPVWTPPAPAPAAPPST 172
+ S A P + P P A PPP PP +P + +PPA P
Sbjct: 529 QALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRR 588
Query: 173 PAAPKRRGSSGSVDETLFALPAASEPVIRS 202
P P S TL P P RS
Sbjct: 589 PPTPGPDTSVSGPRLTLALAPGPPPPPSRS 618
Score = 40.4 bits (93), Expect = 0.003
Identities = 41/149 (27%), Positives = 57/149 (38%), Gaps = 37/149 (24%)
Query: 59 PAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPV-APERQPSWDPSPVSST- 116
P+A L +P+ T P P++ VPP+P PA+P + AP R P+ P P +S
Sbjct: 546 PSASLPMSPLATPPPQAPPVLAAPLLQVPPSP----PASPTLQAPRRPPT--PGPDTSVS 599
Query: 117 --------VPAPSP------------------LSAAAVSPSKLPEDDEPP---ARPPPPP 147
P P P S+A +P +L D P A PPP
Sbjct: 600 GPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPP 659
Query: 148 PASVSPQAEPVWTPPAPAPAAPPSTPAAP 176
A ++ W+ P A P AP
Sbjct: 660 DAELAACHPAAWSRGPAPPLAFRGAPGAP 688
Score = 38.9 bits (89), Expect = 0.008
Identities = 47/171 (27%), Positives = 58/171 (33%), Gaps = 33/171 (19%)
Query: 57 RKP----AAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSP 112
RKP A G+ A +P + P G PA R P AP + + P P
Sbjct: 55 RKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNT-SPGP 113
Query: 113 VSSTVPA-----PSPLSA----------------------AAVSPSKLPEDDEPPARPPP 145
VSS A P PL +A+S + P P
Sbjct: 114 VSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS 173
Query: 146 PPPASVSPQAEPVWTPPAPAPAAPPSTPA-APKRRGSSGSVDETLFALPAA 195
P A S A P PAP+A P P P++ SS S T PAA
Sbjct: 174 PAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAA 224
Score = 31.2 bits (69), Expect = 1.7
Identities = 24/83 (28%), Positives = 30/83 (36%), Gaps = 9/83 (10%)
Query: 50 EELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPP-----APRGPLPAAPPVAPER 104
EEL + P G +A+P P A A + PP AP PLP P P
Sbjct: 640 EELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGS 699
Query: 105 QPS----WDPSPVSSTVPAPSPL 123
++ S PAP L
Sbjct: 700 ADGLCTIYETEGPESATPAPGAL 722
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
Length = 816
Score = 63.9 bits (154), Expect = 2e-10
Identities = 47/145 (32%), Positives = 62/145 (42%), Gaps = 27/145 (18%)
Query: 59 PAAGLSAAPVPTAPAA---------GAPLMDFGNDFVPPAPRGPLPAAPPVAP------- 102
P+A S +P+ PA G+P + + F+P P PL PP AP
Sbjct: 306 PSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP 365
Query: 103 -ERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPAS--VSPQAEPVW 159
+ PS SP S + PSP + A++ L PP PP P S SP P
Sbjct: 366 LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSA 425
Query: 160 TPPAPAPAA--------PPSTPAAP 176
TPP+ AP + PPS PA+P
Sbjct: 426 TPPSQAPPSLAAPPLQVPPSPPASP 450
Score = 53.5 bits (127), Expect = 3e-07
Identities = 46/155 (29%), Positives = 64/155 (41%), Gaps = 13/155 (8%)
Query: 65 AAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLS 124
A P P AP A A + PP+P P +PP +P PS P + A PL
Sbjct: 382 ATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ 441
Query: 125 AAAVSPSKLPEDDEPPARPPP--PPP--------ASVSPQAEP-VWTPPAPAPAAPPSTP 173
P+ P P A PPP PPP A PQA P + TPP A +PP++
Sbjct: 442 VPPSPPASPPMS--PSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASF 499
Query: 174 AAPKRRGSSGSVDETLFALPAASEPVIRSSAVVDL 208
S S+ + A P P + ++ ++ +
Sbjct: 500 PGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQV 534
Score = 52.8 bits (125), Expect = 5e-07
Identities = 44/136 (32%), Positives = 55/136 (40%), Gaps = 26/136 (19%)
Query: 59 PAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVP 118
P A +P T P+ P + VPP+P A+PP++ PS P P +
Sbjct: 415 PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPP----ASPPMS----PSATPPPQAPPPL 466
Query: 119 APSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQA----------EPVWTPPAPAP-- 166
A PL A P P PP + P PPAS QA P+ TPP AP
Sbjct: 467 AAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV 526
Query: 167 ------AAPPSTPAAP 176
PPS PA+P
Sbjct: 527 LAAPLLQVPPSPPASP 542
Score = 52.0 bits (123), Expect = 9e-07
Identities = 52/200 (26%), Positives = 71/200 (35%), Gaps = 44/200 (22%)
Query: 17 PRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAG----------LSAA 66
PRP P+ + + P E + E E R+P+AG LS++
Sbjct: 181 PRPAPSARPR----PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSS 236
Query: 67 PVPTAPAAGAPLMDFGNDFVPPAPRGPLPAA------PPVAPERQPSWDPSPVSSTVPAP 120
P + A + G P P P P P V P R+ + S+ P
Sbjct: 237 ATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLA 296
Query: 121 SPLSAAAVSPSKLPEDDEPPARPPPPPPASV----------------SPQAEPVWTPPAP 164
+P +A SPS P P+ P PP + SP P+ TPP
Sbjct: 297 TPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQ 356
Query: 165 AP--------AAPPSTPAAP 176
AP APPS PA+P
Sbjct: 357 APPALALPPLQAPPSPPASP 376
Score = 47.4 bits (111), Expect = 2e-05
Identities = 46/150 (30%), Positives = 59/150 (39%), Gaps = 15/150 (10%)
Query: 63 LSAAP--VPTAPAAGAPLMDFGNDFVPPAPRGPLP-AAPPVAPERQPSWDPSPVSSTVPA 119
L+A P VP +P A P+ + P P+ P P AAPP+ + P P P +T P
Sbjct: 435 LAAPPLQVPPSPPASPPM----SPSATPPPQAPPPLAAPPLQLAKPPPQAP-PALATPPL 489
Query: 120 PSPLSAAAVSPSKLPEDDE------PPARPPPP-PPASVSPQAEPVWTPPAPAPAAPPST 172
+ S A P + P P A PPP PP +P + +PPA P
Sbjct: 490 QALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRR 549
Query: 173 PAAPKRRGSSGSVDETLFALPAASEPVIRS 202
P P S TL P P RS
Sbjct: 550 PPTPGPDTSVSGPRLTLALAPGPPPPPSRS 579
Score = 40.4 bits (93), Expect = 0.003
Identities = 41/149 (27%), Positives = 57/149 (38%), Gaps = 37/149 (24%)
Query: 59 PAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPV-APERQPSWDPSPVSST- 116
P+A L +P+ T P P++ VPP+P PA+P + AP R P+ P P +S
Sbjct: 507 PSASLPMSPLATPPPQAPPVLAAPLLQVPPSP----PASPTLQAPRRPPT--PGPDTSVS 560
Query: 117 --------VPAPSP------------------LSAAAVSPSKLPEDDEPP---ARPPPPP 147
P P P S+A +P +L D P A PPP
Sbjct: 561 GPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPP 620
Query: 148 PASVSPQAEPVWTPPAPAPAAPPSTPAAP 176
A ++ W+ P A P AP
Sbjct: 621 DAELAACHPAAWSRGPAPPLAFRGAPGAP 649
Score = 31.6 bits (70), Expect = 1.3
Identities = 50/172 (29%), Positives = 60/172 (34%), Gaps = 44/172 (25%)
Query: 57 RKP----AAGLSAAPVP-TAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPS 111
RKP A G+ A +P +AP AG PPA G APP + P
Sbjct: 55 RKPLAERAGGIGGATIPESAPRAGPTRTSR-----PPAS-GRGERAPPAK-----NTSPG 103
Query: 112 PVSSTVPA-----PSPLSA----------------------AAVSPSKLPEDDEPPARPP 144
PVSS A P PL +A+S + P P
Sbjct: 104 PVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTP 163
Query: 145 PPPPASVSPQAEPVWTPPAPAPAAPPSTPA-APKRRGSSGSVDETLFALPAA 195
P A S A P PAP+A P P P++ SS S T PAA
Sbjct: 164 SPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAA 215
Score = 31.2 bits (69), Expect = 1.7
Identities = 24/83 (28%), Positives = 30/83 (36%), Gaps = 9/83 (10%)
Query: 50 EELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPP-----APRGPLPAAPPVAPER 104
EEL + P G +A+P P A A + PP AP PLP P P
Sbjct: 601 EELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGS 660
Query: 105 QPS----WDPSPVSSTVPAPSPL 123
++ S PAP L
Sbjct: 661 ADGLCTIYETEGPESATPAPGAL 683
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 63.5 bits (153), Expect = 3e-10
Identities = 55/172 (31%), Positives = 73/172 (42%), Gaps = 38/172 (22%)
Query: 23 FKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAG---LSAAPVPTAPAAGAPLM 79
F+ +F E + EEEEEEE+E+E+E+LEE+E LE A G A P PT P A
Sbjct: 931 FEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPA----- 985
Query: 80 DFGNDFVPPAPRGPLPAAPPVAPE-------RQPSWDPSPVSSTVPAPSPLSAAAVSPSK 132
+PP P P P PE +P + + T P +P A S +
Sbjct: 986 ------LPP-PESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAP--EALPSQGE 1036
Query: 133 LPEDDEPPARPPPP----------PPASVSPQAEPVWTPPAPAPAAPPSTPA 174
+ + E PA PPP PP + + E P PP TPA
Sbjct: 1037 VEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQP----PPETPA 1084
Score = 52.4 bits (124), Expect = 7e-07
Identities = 50/179 (27%), Positives = 66/179 (36%), Gaps = 55/179 (30%)
Query: 5 DQSPLVSSSDSPPR------------PQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEEL 52
++ P+++ S +PP P+PAF + E D E E + +D + E
Sbjct: 735 NEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPE- 793
Query: 53 EVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSP 112
GL P P A P P AP GP A+PPV + +P P+
Sbjct: 794 ---------GLPPLPPPPPSGATPP---------PIAPTGPPTASPPVPAKEEPEELPA- 834
Query: 113 VSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVS---PQAEPVWTPPAPAPAA 168
AP PL PP PPPP P V+ PQ P TP P A
Sbjct: 835 ------APGPLP--------------PPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPA 873
Score = 45.4 bits (106), Expect = 9e-05
Identities = 43/168 (25%), Positives = 59/168 (35%), Gaps = 19/168 (11%)
Query: 30 EPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPA 89
E E+EEEEEEEEEE+E+E+ E+ E E +F +F
Sbjct: 888 EEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEE--------EFEEEF--EE 937
Query: 90 PRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPA 149
G L E + + + + V P PPA PPP P
Sbjct: 938 EEGELEE----EEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPP 993
Query: 150 SVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASE 197
V P+ E P P P + RG+ + ALP+ E
Sbjct: 994 KVQPEPE-----PEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGE 1036
Score = 40.8 bits (94), Expect = 0.002
Identities = 38/118 (32%), Positives = 45/118 (38%), Gaps = 19/118 (16%)
Query: 59 PAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVP 118
P S P PT P P FG R P PA E + S V ++
Sbjct: 738 PILAPSGTPPPTIP----PDETFGG-------RVPRPAFVHYDKE-----EASDVEISLE 781
Query: 119 APSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAP 176
+ S S V P LP PP PPP ++P P +PP PA P PAAP
Sbjct: 782 SDSDDSVVIV-PEGLPPLPPPPPSGATPPP--IAPTGPPTASPPVPAKEEPEELPAAP 836
Score = 36.6 bits (83), Expect = 0.040
Identities = 29/98 (29%), Positives = 41/98 (41%), Gaps = 14/98 (14%)
Query: 88 PAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARP---- 143
P+PR P PP+A Q ++ ++ S S A V+ + L PP +P
Sbjct: 590 PSPRCP----PPLACALQ-AFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPT 644
Query: 144 -----PPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAP 176
P PPP + SP P + PP P P+ A P
Sbjct: 645 CPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGP 682
Score = 33.9 bits (76), Expect = 0.26
Identities = 29/95 (30%), Positives = 33/95 (34%), Gaps = 22/95 (23%)
Query: 95 PAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPP-------P 147
P PP+ P P+PV APSP A PP PP P P
Sbjct: 633 PRVPPLQPMGPTCPTPAPVPPP-EAPSPFRA-------------PPFHPPGPMPSVGSMP 678
Query: 148 PASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSS 182
A P A P+ P P+A P P G S
Sbjct: 679 SAGPMPSAGPM-PSAGPVPSARPGPPTTANHLGLS 712
Score = 33.5 bits (75), Expect = 0.34
Identities = 50/196 (25%), Positives = 61/196 (31%), Gaps = 67/196 (34%)
Query: 66 APVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPA--PSPL 123
APVP P A +P F PP P + + P P PS P P + VP+ P P
Sbjct: 649 APVPP-PEAPSPFR--APPFHPPGPMPSVGSMPSAGP--MPSAGPMPSAGPVPSARPGPP 703
Query: 124 SAA-----------AVSPSKLPEDDE------------PPARPPP------------PPP 148
+ A +V P LP + P PPP P P
Sbjct: 704 TTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRP 763
Query: 149 ASVS------------------------PQAEPVWTPPAPAPAAPPS-TPAAPKRRGSSG 183
A V P+ P PP P+ A PP P P
Sbjct: 764 AFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPV 823
Query: 184 SVDETLFALPAASEPV 199
E LPAA P+
Sbjct: 824 PAKEEPEELPAAPGPL 839
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 61.6 bits (148), Expect = 1e-09
Identities = 57/197 (28%), Positives = 73/197 (37%), Gaps = 17/197 (8%)
Query: 11 SSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERK---PAAGLSAAP 67
SSS S + E E+EEEE+ L R+ P P
Sbjct: 1036 SSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVP 1095
Query: 68 VPTAPAAGAPLMDFGNDFVPPA-PRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAA 126
VP AG+P+ PA P GP +PP AP R P P PAP+P
Sbjct: 1096 VPER-VAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGP-----PAPAP---- 1145
Query: 127 AVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTP-AAPKRRGSSGSV 185
P + P P PP +VS A V P P PA PP P R + V
Sbjct: 1146 --RPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGV 1203
Query: 186 DETLFALPAASEPVIRS 202
+ T+ LP +++S
Sbjct: 1204 ERTIRNLPLDHASLVKS 1220
Score = 51.2 bits (121), Expect = 2e-06
Identities = 52/220 (23%), Positives = 83/220 (37%), Gaps = 57/220 (25%)
Query: 29 REPEDEEEEEEEEEEDEDEDLEELEVLERKP----------------------------- 59
+E E++EE++EE++EDED EE +K
Sbjct: 970 QESSSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDS 1029
Query: 60 ----------AAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWD 109
++ S++ ++ ++ + D LP+A P P P
Sbjct: 1030 TSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASP-PPREVPVPT 1088
Query: 110 PSPVSSTVPAP------SPLSAAAVSPSKL--PEDDEPPA---RPPPPPPASVSPQAEPV 158
P+PV VP +PL SP++ P ++ PP+ RPP PP +P P
Sbjct: 1089 PAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPRPD 1148
Query: 159 WTPPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEP 198
P +P P PP PK+R + S + +PA P
Sbjct: 1149 ERPSSPIPLLPP-----PKKRRKTVSF-SAIEVVPAPEPP 1182
Score = 42.7 bits (99), Expect = 6e-04
Identities = 44/152 (28%), Positives = 58/152 (38%), Gaps = 22/152 (14%)
Query: 37 EEEEEEEDEDEDLEELEVLERKPA-AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGP-L 94
+ EEEEE+ L + P+ +G P APA +F AP G
Sbjct: 509 DTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPA----------NFEDVAPTGSGE 558
Query: 95 PAAPPVAPERQPSWDPSPVSS--TVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPP---- 148
P A +P+ SP SS + + P+ P PP PPPPPP
Sbjct: 559 PGATRESPKANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYL 618
Query: 149 ASVS---PQAEPVW-TPPAPAPAAPPSTPAAP 176
AS+ P +P + PP P PP P P
Sbjct: 619 ASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPP 650
Score = 40.0 bits (92), Expect = 0.004
Identities = 22/62 (35%), Positives = 26/62 (41%), Gaps = 4/62 (6%)
Query: 87 PPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPP 146
PPAP P PP P P P +++P P A P+ PP PPPP
Sbjct: 595 PPAPTPPQQPPPPPPPPPPPP----PYLASLPLGYPPHQPAYLLPPRPDGPPPPEYPPPP 650
Query: 147 PP 148
PP
Sbjct: 651 PP 652
Score = 38.9 bits (89), Expect = 0.008
Identities = 28/89 (31%), Positives = 35/89 (39%), Gaps = 4/89 (4%)
Query: 90 PRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPP--- 146
PR PP AP + + + P S T P S + P + PP PP P
Sbjct: 384 PRRATREEPPGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGG 443
Query: 147 -PPASVSPQAEPVWTPPAPAPAAPPSTPA 174
SP+ E V T P PA A +PA
Sbjct: 444 GGGGGPSPEREEVRTSPRPASPARSGSPA 472
Score = 33.5 bits (75), Expect = 0.34
Identities = 38/148 (25%), Positives = 53/148 (35%), Gaps = 25/148 (16%)
Query: 32 EDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPA--------AGAPLMDFGN 83
ED E E +E + L +LE A L+ P P APA A A L
Sbjct: 1275 EDSEATETSDEAERPRPLLSHILLEHNYA--LAVKPTPPAPALRPPEPVPAPAALFSSPA 1332
Query: 84 DFVPPAPRGPLPAAPPVAPER------------QPSWDPSPVSSTVPAPSPLSAAAVSPS 131
D V AP + A P++ + + S+ + S A+
Sbjct: 1333 DEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDGEGALRRR 1392
Query: 132 KLPEDDE---PPARPPPPPPASVSPQAE 156
L PP PPPPPP + P++E
Sbjct: 1393 SLRSHARRRRPPPPPPPPPPRAYEPRSE 1420
Score = 32.7 bits (73), Expect = 0.58
Identities = 18/45 (40%), Positives = 24/45 (53%)
Query: 2 EDLDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDED 46
E L+ +V + P+PQ + + E E EEE EEEEEE D
Sbjct: 1334 EVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSD 1378
Score = 32.3 bits (72), Expect = 0.76
Identities = 30/87 (34%), Positives = 37/87 (42%), Gaps = 17/87 (19%)
Query: 88 PAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPP 147
PA RG LPA P V + + S P PL +S L + +P PP
Sbjct: 1263 PARRG-LPALPAVEDS-----EATETSDEAERPRPL----LSHILLEHNYALAVKPTPPA 1312
Query: 148 PASVSPQAEPVWTPPAPAPAAPPSTPA 174
PA P+ P PAPAA S+PA
Sbjct: 1313 PALRPPE-------PVPAPAALFSSPA 1332
Score = 31.6 bits (70), Expect = 1.3
Identities = 26/96 (27%), Positives = 33/96 (34%), Gaps = 17/96 (17%)
Query: 71 APAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSP 130
+P + M+ +D RG P P P++ P P P P P S P
Sbjct: 575 SPCSSGDDMEISDD-----DRGGSPPPAPTPPQQPP---PPPPPPPPPPPYLASLPLGYP 626
Query: 131 SKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAP 166
P PP PPPP + PP P P
Sbjct: 627 PHQPAYLLPPRPDGPPPPE---------YPPPPPPP 653
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 61.6 bits (148), Expect = 1e-09
Identities = 59/219 (26%), Positives = 83/219 (37%), Gaps = 29/219 (13%)
Query: 4 LDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGL 63
L++SPL +SPP PA + PE EE EEL A+ L
Sbjct: 515 LEESPLSPPEESPP--SPALETPLSPPPEASPLSPPFEESPLSPPPEELPTSPPPEASRL 572
Query: 64 SA-------------APVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDP 110
S +P+ P A F + P P + PP A P +
Sbjct: 573 SPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPED 632
Query: 111 SPVS--------STVPAPSPLSAAAVSPSKLPEDDEPPARPPPPP-PASVSPQAEPVWTP 161
SP+S S P S LS V P +E P PPP P S P+A + P
Sbjct: 633 SPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLSPP 692
Query: 162 PAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVI 200
P +P +PP P+ +S +++L +LP P++
Sbjct: 693 PEDSPTSPP-----PEDSPASPPPEDSLMSLPLEESPLL 726
Score = 52.8 bits (125), Expect = 5e-07
Identities = 46/158 (29%), Positives = 64/158 (40%), Gaps = 10/158 (6%)
Query: 31 PEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPP-- 88
P +E EE E L P L A+P+P A PL + + PP
Sbjct: 443 PPEESPLSPPPEESPTSPPPEASRLSPPPEE-LPASPLPEALHLSRPLEE--SPLSPPPE 499
Query: 89 -APRGPLPAAPPVAPERQPSWDPSPVSSTVPA-PSPLSAAAVSPSKLPEDDEPPARPPPP 146
+P P P + P +P + P S PA +PLS + P +E P PPP
Sbjct: 500 ESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEESPLSPPPE 559
Query: 147 P-PASVSPQAEPVWTPPAPAPAAPP--STPAAPKRRGS 181
P S P+A + PP +P +PP +P +P S
Sbjct: 560 ELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEAS 597
Score = 52.8 bits (125), Expect = 5e-07
Identities = 51/186 (27%), Positives = 67/186 (36%), Gaps = 27/186 (14%)
Query: 2 EDLDQSPLVSS-------SDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEV 54
E+L SPL + +SP P P P E E+ L E
Sbjct: 472 EELPASPLPEALHLSRPLEESPLSPPPE------ESPLSPPPESSPFSPLEESPLSPPEE 525
Query: 55 LERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVS 114
PA +P P A P F + P P + PP A P + SP+S
Sbjct: 526 SPPSPALETPLSPPPEASPLSPP---FEESPLSPPPEELPTSPPPEASRLSPPPEESPMS 582
Query: 115 STVPAPSPLSAAAVSPSKLPEDDEPPARPPP------PPPA----SVSPQAEPVWTPPAP 164
P SP+S + P +E P PPP PPP S P+ P+ PP
Sbjct: 583 PP-PEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEE 641
Query: 165 APAAPP 170
+P +PP
Sbjct: 642 SPMSPP 647
Score = 49.7 bits (117), Expect = 5e-06
Identities = 55/199 (27%), Positives = 75/199 (37%), Gaps = 40/199 (20%)
Query: 5 DQSPLVSSSDSP---PRPQPA-FKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPA 60
++S L S+ P PRP+ + + + P E+ EE + EEL + P
Sbjct: 829 EESHLSPQSEEPCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFP--PP 886
Query: 61 AGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPS--PVSSTVP 118
S +P+ PA P P PLP P++P +PS P P P
Sbjct: 887 GEPSLSPLLGEPALSEP---------GEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPP 937
Query: 119 APSPLSAAAVSPSKLP-------------EDDEPPARPP------PPPPASVSPQAEPVW 159
SP+ AA P+ P D E P P PPP + EPV
Sbjct: 938 PLSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPV- 996
Query: 160 TPPAPAPAAP--PSTPAAP 176
PP P +P P PA+P
Sbjct: 997 -PPMILPPSPGSPVGPASP 1014
Score = 48.5 bits (114), Expect = 1e-05
Identities = 48/158 (30%), Positives = 64/158 (40%), Gaps = 25/158 (15%)
Query: 56 ERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSS 115
E KP L A V P APL + +PP PL +PP PE P+ P S
Sbjct: 415 EAKP---LGKAGVQLEPQLEAPLNE-EMPLLPPPEESPL--SPP--PEESPTSPPPEASR 466
Query: 116 TVPAPSPLSAAAV------------SPSKLPEDDEPPARPP---PPPPASVSPQAEPVWT 160
P P L A+ + SP P ++ P + PP P P SP + P +
Sbjct: 467 LSPPPEELPASPLPEALHLSRPLEESPLSPPPEESPLSPPPESSPFSPLEESPLSPPEES 526
Query: 161 PPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEP 198
PP+PA P S P P+ S +E+ + P P
Sbjct: 527 PPSPALETPLSPP--PEASPLSPPFEESPLSPPPEELP 562
Score = 45.4 bits (106), Expect = 9e-05
Identities = 43/174 (24%), Positives = 59/174 (33%), Gaps = 10/174 (5%)
Query: 2 EDLDQSPLVSSSDSPPRPQ-----PAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLE 56
ED SP S P P+ P + P +E EE E L
Sbjct: 631 EDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEESPLSPPPEESPTSPPPEASRLS 690
Query: 57 RKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSST 116
P ++ P +PA+ P + + +P PLP P + P + P S
Sbjct: 691 PPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEPQLCPRSE-----GPHLSP 745
Query: 117 VPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPP 170
P LS P P+ +EP P P P + EP +P A P P
Sbjct: 746 RPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEEPHLSPQAEGPHLSP 799
Score = 43.1 bits (100), Expect = 4e-04
Identities = 38/115 (33%), Positives = 48/115 (41%), Gaps = 10/115 (8%)
Query: 90 PRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPA 149
P P P PP P + P+ + P+ PS LS P+ L E EPP P P
Sbjct: 859 PLSPRPEKPPEEPGQCPAPEELPLFPPPGEPS-LSPLLGEPA-LSEPGEPPLSPLPEE-L 915
Query: 150 SVSPQAEPVWTP------PAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEP 198
+SP EP +P P P P +P T AAP G + E F S+P
Sbjct: 916 PLSPSGEPSLSPQLMPPDPLPPPLSPIITAAAPPALSPLGEL-EYPFGAKGDSDP 969
Score = 39.7 bits (91), Expect = 0.005
Identities = 42/126 (33%), Positives = 52/126 (41%), Gaps = 17/126 (13%)
Query: 56 ERKPAAGLSAAPVPTAP---AAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDP-- 110
E PA L+ +P P+ P G+ + + P P+ P P + P R DP
Sbjct: 2351 EPPPAQALAPSP-PSHPDIFRPGSYTDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFS 2409
Query: 111 -------SPVSSTVP-APSPLSAAAVSPSKL-PEDDEP-PARPPPPPPASVSPQAEPVWT 160
S SS P P PLSA A PS + P P P PP P S P A P+
Sbjct: 2410 RVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFA-PLHK 2468
Query: 161 PPAPAP 166
PP P P
Sbjct: 2469 PPRPQP 2474
Score = 39.7 bits (91), Expect = 0.005
Identities = 21/61 (34%), Positives = 30/61 (49%), Gaps = 3/61 (4%)
Query: 87 PPAPRGPLPAAPPVAPERQPSWDP---SPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARP 143
PP+P P PA+PP P + +P PV S +P S +A P P ++ +RP
Sbjct: 4917 PPSPLAPSPASPPTEPLVELPTEPLAEPPVPSPLPLASSPESARPKPRARPPEEGEDSRP 4976
Query: 144 P 144
P
Sbjct: 4977 P 4977
Score = 38.9 bits (89), Expect = 0.008
Identities = 44/186 (23%), Positives = 66/186 (35%), Gaps = 25/186 (13%)
Query: 10 VSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVP 69
V ++D P Q A K ++ +++ E + ++ + ++ +PA L P P
Sbjct: 2052 VPAADKAPYLQKA-KDNRAAHRINKVQKQAESQINKQTKVGDIARKTDRPALHLRIPPQP 2110
Query: 70 TA----PAAGAPLMDFGNDFVPPA-----------PRGPLPAAPPVAPERQPSWDPSPVS 114
A P A AP + G+ P P G +P P +P P V
Sbjct: 2111 GALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSVPG--PDSPGELFLKLPPQVP 2168
Query: 115 STVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQ-------AEPVWTPPAPAPA 167
+ VP+ P A P + PP PP P P Q + P P
Sbjct: 2169 AQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFHT 2228
Query: 168 APPSTP 173
PP TP
Sbjct: 2229 TPPGTP 2234
Score = 38.5 bits (88), Expect = 0.011
Identities = 44/177 (24%), Positives = 61/177 (34%), Gaps = 22/177 (12%)
Query: 2 EDLDQSPLVSSSDSPPRPQ-----PAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLE 56
E+ SP S P P+ P F+ + P +E E E +
Sbjct: 577 EESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMS 636
Query: 57 RKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSST 116
P + P + + P++ + PP PL +PP PE P+ P S
Sbjct: 637 PPPEESPMSPPPEVSRLSPLPVV---SRLSPPPEESPL--SPP--PEESPTSPPPEASRL 689
Query: 117 VPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTP 173
P P SP+ P +D P A PPP P E +P P P P P
Sbjct: 690 SPPPED------SPTSPPPEDSP-ASPPPEDSLMSLPLEE---SPLLPLPEEPQLCP 736
Score = 38.5 bits (88), Expect = 0.011
Identities = 50/228 (21%), Positives = 78/228 (34%), Gaps = 27/228 (11%)
Query: 4 LDQSPLVSSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGL 63
L++SPL+ + P + PE+ EE EE + + L
Sbjct: 720 LEESPLLPLPEEPQLCPRSEGPHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCL 779
Query: 64 SAAPVPT--APAAGAPLMDFGNDFVPPAPR------GPLPAAPPVAPERQPSW----DPS 111
A P +P A P + + + +P+ P+P P ++P+ + S
Sbjct: 780 CAVPEEPHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEE 839
Query: 112 PVSSTVPAPSPLSAAAVSPSKLPEDDEPPARP-------------PPPPPASVSPQAEPV 158
P S P S LS P P ++PP P PP P+ EP
Sbjct: 840 PCLSPRPEESHLSPELEKPPLSPRPEKPPEEPGQCPAPEELPLFPPPGEPSLSPLLGEPA 899
Query: 159 WTPPAPAPAA--PPSTPAAPKRRGSSGSVDETLFALPAASEPVIRSSA 204
+ P P + P P +P S LP P+I ++A
Sbjct: 900 LSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAAA 947
Score = 36.6 bits (83), Expect = 0.040
Identities = 26/101 (25%), Positives = 39/101 (38%), Gaps = 10/101 (9%)
Query: 92 GPLPAAPPVAPERQPSWDPSPVSSTV-PAPSPLSAAAVSPSKLPEDDEPPARPPPPPPAS 150
GP P PP P + PV V P P P S P++ + P++ P P
Sbjct: 4280 GPRPQGPPRLPAPPGALSTGPVLGPVHPTPPPSS---------PQEPKRPSQLPSPSSQL 4330
Query: 151 VSPQAEPVWTPPAPAPAAPPSTPAAPKRRGSSGSVDETLFA 191
+ P P P P P P + ++ + +TLF+
Sbjct: 4331 PTEAQLPPTHPGTPKPQGPTLEPPPGRVSPAAAQLADTLFS 4371
Score = 35.8 bits (81), Expect = 0.068
Identities = 33/122 (27%), Positives = 48/122 (39%), Gaps = 18/122 (14%)
Query: 37 EEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPA 96
+ E E++ + + L EL + ++ L A AAGA PP G P+
Sbjct: 2674 QTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGA--------VGPPGSWGAEPS 2725
Query: 97 APPVAPERQPSWDPSPVSSTVPA-------PSPLSAAAVSPSKLPEDDEPPARPPPPPPA 149
+P Q S +P + T PS LS + P P DD PPP P+
Sbjct: 2726 SPAF---EQLSRGQTPFAGTQDKSSLVGLPPSKLSGPILGPGSFPSDDRLSRPPPPATPS 2782
Query: 150 SV 151
S+
Sbjct: 2783 SM 2784
Score = 35.8 bits (81), Expect = 0.068
Identities = 24/84 (28%), Positives = 30/84 (35%), Gaps = 13/84 (15%)
Query: 102 PERQPSWDPSPVSSTVPA-------PSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQ 154
P ++P SP+ + P P + P PP P PP S P
Sbjct: 4242 PYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPV 4301
Query: 155 AEPVWTPPAPAPAAPPSTPAAPKR 178
PV P PPS+P PKR
Sbjct: 4302 LGPV------HPTPPPSSPQEPKR 4319
Score = 35.0 bits (79), Expect = 0.12
Identities = 40/152 (26%), Positives = 54/152 (35%), Gaps = 31/152 (20%)
Query: 65 AAPVPTAPAAGAPLMDFGND------FVPPAPRGPLPAAPPV-----------------A 101
AAP+ P + P + + +PP+P P+ A P+
Sbjct: 974 AAPILETPISPPPEANCTDPEPVPPMILPPSPGSPVGPASPILMEPLPPQCSPLLQHSLV 1033
Query: 102 PERQPSWDPSPVSSTVPAPSPLS--AAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVW 159
P+ P SP + + PSPLS V S E E P P EP
Sbjct: 1034 PQNSPPSQCSPPALPLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPEC---PALEPSA 1090
Query: 160 TPPAPAPAAPPSTPA---APKRRGSSGSVDET 188
T P P+P S PA AP SG ++T
Sbjct: 1091 TSPLPSPMGDLSCPAPSPAPALDDFSGLGEDT 1122
Score = 34.3 bits (77), Expect = 0.20
Identities = 25/82 (30%), Positives = 32/82 (39%), Gaps = 7/82 (8%)
Query: 102 PERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTP 161
P +PS PSP+ APSP S +LP EP A PP P P ++ E
Sbjct: 4910 PPEEPSPPPSPL-----APSPASPPTEPLVELP--TEPLAEPPVPSPLPLASSPESARPK 4962
Query: 162 PAPAPAAPPSTPAAPKRRGSSG 183
P P P+ + G
Sbjct: 4963 PRARPPEEGEDSRPPRLKKWKG 4984
Score = 33.5 bits (75), Expect = 0.34
Identities = 26/81 (32%), Positives = 32/81 (39%), Gaps = 19/81 (23%)
Query: 118 PAPSP---------LSAAAVSPSKLPEDDEPPARPPPPPPASVSP--------QAEPVWT 160
PAP P +S V P +EP P P P+ SP EP+
Sbjct: 4884 PAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLVELPTEPLAE 4943
Query: 161 PPAPAPAAPPSTP--AAPKRR 179
PP P+P S+P A PK R
Sbjct: 4944 PPVPSPLPLASSPESARPKPR 4964
Score = 33.1 bits (74), Expect = 0.44
Identities = 34/109 (31%), Positives = 43/109 (39%), Gaps = 22/109 (20%)
Query: 86 VPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLPEDDEP-PARP- 143
+PP P G L + PP A P+ + P+ LS +A K P P P P
Sbjct: 2106 IPPQP-GALGSPPPAAA-------PTIFIGSPTTPAGLSTSADGFLKPPAGSVPGPDSPG 2157
Query: 144 ------PPPPPASVSPQAEPVWTPPAPA-----PAAPPSTPAAPKRRGS 181
PP PA V P +P PA P APP+ P P G+
Sbjct: 2158 ELFLKLPPQVPAQV-PSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGA 2205
Score = 32.7 bits (73), Expect = 0.58
Identities = 32/106 (30%), Positives = 44/106 (41%), Gaps = 14/106 (13%)
Query: 87 PPAPRGPL-PAAPPVAPER-----QPSWDPSPVSSTVPAPSPLSAAAVSPSKLPED-DEP 139
P + PL P A V P+ +P +P P + P+P P P + +P
Sbjct: 2324 PDVFKAPLTPRASQVEPQSPGLGLRPQ-EPPPAQALAPSP-PSHPDIFRPGSYTDPYAQP 2381
Query: 140 PARPPPPPPASVSPQAEPVWTPPAPAPAAPPS-TPAAPKRRGSSGS 184
P P P PP P PP P+ P S PA+P+ + SS S
Sbjct: 2382 PLTPRPQPP----PPESCCALPPRSLPSDPFSRVPASPQSQSSSQS 2423
Score = 32.7 bits (73), Expect = 0.58
Identities = 53/208 (25%), Positives = 66/208 (31%), Gaps = 28/208 (13%)
Query: 11 SSSDSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPT 70
SSS SP P+P F P + + + R P A L P P
Sbjct: 2419 SSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQS-----RDPFAPLHKPPRPQ 2473
Query: 71 AP-----AAGAPLMDFGNDFVPPA-PRGPLPAAPPVAPERQP-SWDPSP-VSSTVPAPSP 122
P A G P A P GP P QP ++ SP + V PSP
Sbjct: 2474 PPEVAFKAGSLAHTSLGAGGFPAALPAGPAGELHAKVPSGQPPNFVRSPGTGAFVGTPSP 2533
Query: 123 LSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPST---------- 172
+ P + EP +PP P P P P P P ST
Sbjct: 2534 MRFTF--PQAV---GEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGNFH 2588
Query: 173 PAAPKRRGSSGSVDETLFALPAASEPVI 200
P+ SSGS E+ P V+
Sbjct: 2589 PSGSPLGPSSGSTGESYGLSPLRPPSVL 2616
Score = 31.6 bits (70), Expect = 1.3
Identities = 27/112 (24%), Positives = 42/112 (37%), Gaps = 6/112 (5%)
Query: 68 VPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAA 127
+PT P + L+ N PP P LP PP + +++ +P P ++A
Sbjct: 4600 LPTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTPSEELGEHPKDAASAR 4659
Query: 128 VSPSKLPEDDEP------PARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTP 173
S L + E A P PP + + E +P P S+P
Sbjct: 4660 DSERALRDTSEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSP 4711
Score = 30.8 bits (68), Expect = 2.2
Identities = 39/138 (28%), Positives = 52/138 (37%), Gaps = 29/138 (21%)
Query: 85 FVPPAPRGPLPAAPP----VAPERQP------SWDPSPVSSTVPAPSPLSAAAVSPS--- 131
F PP P G P P VA + QP S P PL A V
Sbjct: 372 FSPPEP-GDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQL 430
Query: 132 KLPEDDE-----PPARPP--PPP---PASVSPQAEPVWTPPAPAPAAPPSTPAAPKRRGS 181
+ P ++E PP P PPP P S P+A + PP PA+P P+
Sbjct: 431 EAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASP-----LPEALHL 485
Query: 182 SGSVDETLFALPAASEPV 199
S ++E+ + P P+
Sbjct: 486 SRPLEESPLSPPPEESPL 503
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 61.6 bits (148), Expect = 1e-09
Identities = 49/162 (30%), Positives = 68/162 (41%), Gaps = 12/162 (7%)
Query: 14 DSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPA 73
++P +P + RE E++ +E ++ ++ +E E ER AG S P T P
Sbjct: 500 EAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKER--GAGASGGP-STDPL 556
Query: 74 AGAPLMDFGNDFVPPAPRGPLPAAPPV----APERQPSWDPSPVSSTVPAPSPLS-AAAV 128
AG L D + R PAAP + AP P+ P+PV T P P P++
Sbjct: 557 AGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGP 616
Query: 129 SPSKLPEDDEPPARPPPPPPASVSPQAEPVWTP-PAPAPAAP 169
P P +P PPP P P P P P PA P
Sbjct: 617 QPQSAGSTSGPVPQPACPPP---GPAPHPTGPPGPIPVPAPP 655
Score = 43.5 bits (101), Expect = 3e-04
Identities = 37/119 (31%), Positives = 44/119 (36%), Gaps = 16/119 (13%)
Query: 59 PAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVP 118
P S P P A G G+ P P PA PP P P+ P P+ P
Sbjct: 599 PVQPTSPPPGPVAQPTGPQPQSAGSTSGPV----PQPACPPPGPAPHPTGPPGPI----P 650
Query: 119 APSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPK 177
P+P A S S L PPP P S +P P + P P PP AP+
Sbjct: 651 VPAP-PQIATSTSLLAAQS---LVPPPGLPGSSTPGVLPYFPPGLP----PPDAGGAPQ 701
Score = 33.5 bits (75), Expect = 0.34
Identities = 41/167 (24%), Positives = 60/167 (35%), Gaps = 8/167 (4%)
Query: 14 DSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPA 73
D P P F + F RE E +E + ++ E + ++ S PV + P
Sbjct: 354 DDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEP- 412
Query: 74 AGAPLMDFGNDFVPPAPRGPLPA-APPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSK 132
G P ++ + P AP G +PP AP P P + T+ P P+S A
Sbjct: 413 -GCPDVEMPS---PWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKD 468
Query: 133 LPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRR 179
D A S+ + P AP A P P + R
Sbjct: 469 GAISDNTKAALKAALLKSLRSRLRD--GPSAPLEAPEPRKPVTAQER 513
Score = 32.0 bits (71), Expect = 0.99
Identities = 30/101 (29%), Positives = 39/101 (38%), Gaps = 16/101 (15%)
Query: 105 QPSWDP---SPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTP 161
QPS P P V PSP + + + P PP P P ++ Q P +
Sbjct: 402 QPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSE 461
Query: 162 PAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRS 202
PAP PK+ G+ D T AL AA +RS
Sbjct: 462 PAP-----------PKKDGAIS--DNTKAALKAALLKSLRS 489
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 61.6 bits (148), Expect = 1e-09
Identities = 49/162 (30%), Positives = 68/162 (41%), Gaps = 12/162 (7%)
Query: 14 DSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPA 73
++P +P + RE E++ +E ++ ++ +E E ER AG S P T P
Sbjct: 500 EAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKER--GAGASGGP-STDPL 556
Query: 74 AGAPLMDFGNDFVPPAPRGPLPAAPPV----APERQPSWDPSPVSSTVPAPSPLS-AAAV 128
AG L D + R PAAP + AP P+ P+PV T P P P++
Sbjct: 557 AGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGP 616
Query: 129 SPSKLPEDDEPPARPPPPPPASVSPQAEPVWTP-PAPAPAAP 169
P P +P PPP P P P P P PA P
Sbjct: 617 QPQSAGSTSGPVPQPACPPP---GPAPHPTGPPGPIPVPAPP 655
Score = 43.5 bits (101), Expect = 3e-04
Identities = 37/119 (31%), Positives = 44/119 (36%), Gaps = 16/119 (13%)
Query: 59 PAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVP 118
P S P P A G G+ P P PA PP P P+ P P+ P
Sbjct: 599 PVQPTSPPPGPVAQPTGPQPQSAGSTSGPV----PQPACPPPGPAPHPTGPPGPI----P 650
Query: 119 APSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPK 177
P+P A S S L PPP P S +P P + P P PP AP+
Sbjct: 651 VPAP-PQIATSTSLLAAQS---LVPPPGLPGSSTPGVLPYFPPGLP----PPDAGGAPQ 701
Score = 33.5 bits (75), Expect = 0.34
Identities = 41/167 (24%), Positives = 60/167 (35%), Gaps = 8/167 (4%)
Query: 14 DSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPA 73
D P P F + F RE E +E + ++ E + ++ S PV + P
Sbjct: 354 DDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEP- 412
Query: 74 AGAPLMDFGNDFVPPAPRGPLPA-APPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSK 132
G P ++ + P AP G +PP AP P P + T+ P P+S A
Sbjct: 413 -GCPDVEMPS---PWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKD 468
Query: 133 LPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRR 179
D A S+ + P AP A P P + R
Sbjct: 469 GAISDNTKAALKAALLKSLRSRLRD--GPSAPLEAPEPRKPVTAQER 513
Score = 32.0 bits (71), Expect = 0.99
Identities = 30/101 (29%), Positives = 39/101 (38%), Gaps = 16/101 (15%)
Query: 105 QPSWDP---SPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTP 161
QPS P P V PSP + + + P PP P P ++ Q P +
Sbjct: 402 QPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSE 461
Query: 162 PAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRS 202
PAP PK+ G+ D T AL AA +RS
Sbjct: 462 PAP-----------PKKDGAIS--DNTKAALKAALLKSLRS 489
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 61.6 bits (148), Expect = 1e-09
Identities = 49/162 (30%), Positives = 68/162 (41%), Gaps = 12/162 (7%)
Query: 14 DSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPA 73
++P +P + RE E++ +E ++ ++ +E E ER AG S P T P
Sbjct: 500 EAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKER--GAGASGGP-STDPL 556
Query: 74 AGAPLMDFGNDFVPPAPRGPLPAAPPV----APERQPSWDPSPVSSTVPAPSPLS-AAAV 128
AG L D + R PAAP + AP P+ P+PV T P P P++
Sbjct: 557 AGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGP 616
Query: 129 SPSKLPEDDEPPARPPPPPPASVSPQAEPVWTP-PAPAPAAP 169
P P +P PPP P P P P P PA P
Sbjct: 617 QPQSAGSTSGPVPQPACPPP---GPAPHPTGPPGPIPVPAPP 655
Score = 43.5 bits (101), Expect = 3e-04
Identities = 37/119 (31%), Positives = 44/119 (36%), Gaps = 16/119 (13%)
Query: 59 PAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVP 118
P S P P A G G+ P P PA PP P P+ P P+ P
Sbjct: 599 PVQPTSPPPGPVAQPTGPQPQSAGSTSGPV----PQPACPPPGPAPHPTGPPGPI----P 650
Query: 119 APSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPK 177
P+P A S S L PPP P S +P P + P P PP AP+
Sbjct: 651 VPAP-PQIATSTSLLAAQS---LVPPPGLPGSSTPGVLPYFPPGLP----PPDAGGAPQ 701
Score = 33.5 bits (75), Expect = 0.34
Identities = 41/167 (24%), Positives = 60/167 (35%), Gaps = 8/167 (4%)
Query: 14 DSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPA 73
D P P F + F RE E +E + ++ E + ++ S PV + P
Sbjct: 354 DDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEP- 412
Query: 74 AGAPLMDFGNDFVPPAPRGPLPA-APPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSK 132
G P ++ + P AP G +PP AP P P + T+ P P+S A
Sbjct: 413 -GCPDVEMPS---PWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKD 468
Query: 133 LPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRR 179
D A S+ + P AP A P P + R
Sbjct: 469 GAISDNTKAALKAALLKSLRSRLRD--GPSAPLEAPEPRKPVTAQER 513
Score = 32.0 bits (71), Expect = 0.99
Identities = 30/101 (29%), Positives = 39/101 (38%), Gaps = 16/101 (15%)
Query: 105 QPSWDP---SPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTP 161
QPS P P V PSP + + + P PP P P ++ Q P +
Sbjct: 402 QPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSE 461
Query: 162 PAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRS 202
PAP PK+ G+ D T AL AA +RS
Sbjct: 462 PAP-----------PKKDGAIS--DNTKAALKAALLKSLRS 489
>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
sapiens]
Length = 677
Score = 61.6 bits (148), Expect = 1e-09
Identities = 49/162 (30%), Positives = 68/162 (41%), Gaps = 12/162 (7%)
Query: 14 DSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPA 73
++P +P + RE E++ +E ++ ++ +E E ER AG S P T P
Sbjct: 361 EAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKER--GAGASGGP-STDPL 417
Query: 74 AGAPLMDFGNDFVPPAPRGPLPAAPPV----APERQPSWDPSPVSSTVPAPSPLS-AAAV 128
AG L D + R PAAP + AP P+ P+PV T P P P++
Sbjct: 418 AGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGP 477
Query: 129 SPSKLPEDDEPPARPPPPPPASVSPQAEPVWTP-PAPAPAAP 169
P P +P PPP P P P P P PA P
Sbjct: 478 QPQSAGSTSGPVPQPACPPP---GPAPHPTGPPGPIPVPAPP 516
Score = 43.5 bits (101), Expect = 3e-04
Identities = 37/119 (31%), Positives = 44/119 (36%), Gaps = 16/119 (13%)
Query: 59 PAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVP 118
P S P P A G G+ P P PA PP P P+ P P+ P
Sbjct: 460 PVQPTSPPPGPVAQPTGPQPQSAGSTSGPV----PQPACPPPGPAPHPTGPPGPI----P 511
Query: 119 APSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPK 177
P+P A S S L PPP P S +P P + P P PP AP+
Sbjct: 512 VPAP-PQIATSTSLLAAQS---LVPPPGLPGSSTPGVLPYFPPGLP----PPDAGGAPQ 562
Score = 33.5 bits (75), Expect = 0.34
Identities = 41/167 (24%), Positives = 60/167 (35%), Gaps = 8/167 (4%)
Query: 14 DSPPRPQPAFKYQFVREPEDEEEEEEEEEEDEDEDLEELEVLERKPAAGLSAAPVPTAPA 73
D P P F + F RE E +E + ++ E + ++ S PV + P
Sbjct: 215 DDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEP- 273
Query: 74 AGAPLMDFGNDFVPPAPRGPLPA-APPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSK 132
G P ++ + P AP G +PP AP P P + T+ P P+S A
Sbjct: 274 -GCPDVEMPS---PWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKD 329
Query: 133 LPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKRR 179
D A S+ + P AP A P P + R
Sbjct: 330 GAISDNTKAALKAALLKSLRSRLRD--GPSAPLEAPEPRKPVTAQER 374
Score = 32.0 bits (71), Expect = 0.99
Identities = 30/101 (29%), Positives = 39/101 (38%), Gaps = 16/101 (15%)
Query: 105 QPSWDP---SPVSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTP 161
QPS P P V PSP + + + P PP P P ++ Q P +
Sbjct: 263 QPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSE 322
Query: 162 PAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEPVIRS 202
PAP PK+ G+ D T AL AA +RS
Sbjct: 323 PAP-----------PKKDGAIS--DNTKAALKAALLKSLRS 350
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 61.2 bits (147), Expect = 2e-09
Identities = 62/203 (30%), Positives = 83/203 (40%), Gaps = 31/203 (15%)
Query: 21 PAFKYQFVREPEDEEEEEEEEEED-EDEDLEELEVLERK-PAAGLSAAPVP----TAPAA 74
P +K Q + ++EEE++EEEE+D E E+ EE V E PAA A +P T PA
Sbjct: 352 PCWKKQEQKLDDEEEEKKEEEEKDKEGEEKEERAVAEEMMPAAEKEEAKLPPPPLTPPAP 411
Query: 75 GAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSSTVPAPSPLSAAAVSPSKLP 134
P PP P PP+ P P P P+ S P P+ P +P
Sbjct: 412 SPP---------PPLPPPSTSPPPPLCPPPPPPVSPPPLPSPPPPPAQEEQEESPPPVVP 462
Query: 135 ED-DEPPARPPPPPPASVSPQAEPV----WTPPAPAPA----APP--STPAAPKRRGSSG 183
RPP P +A +PP P P+ PP S APK
Sbjct: 463 ATCSRKRGRPPLTPSQRAEREAARAGPEGTSPPTPTPSTATGGPPEDSPTVAPKSTTFLK 522
Query: 184 SVDETLFALPAASEPVIRSSAVV 206
++ + F +P S RSS V+
Sbjct: 523 NIRQ--FIMPVVS---ARSSRVI 540
Score = 49.7 bits (117), Expect = 5e-06
Identities = 48/158 (30%), Positives = 61/158 (38%), Gaps = 45/158 (28%)
Query: 86 VPPAPRGPLPAAPPV----APERQPSWDPSPVSSTVPAPSPLSAAAVSPS----KLPEDD 137
V P R P+ +PPV AP P P+P S+ VP P + P+ L +
Sbjct: 559 VSPVLRPPITTSPPVPQEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTREL 618
Query: 138 EPPARPPPPPPASVSPQA--------------------------EPVWTPP------APA 165
PP PPPPPA P A E V TPP AP
Sbjct: 619 PPPPPAPPPPPAPSPPPAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPE 678
Query: 166 PAAPPS--TPAAPKRR--GSSGSVDETLFALPAASEPV 199
P PP+ +PA P+ R G + + FA P + PV
Sbjct: 679 PEPPPADDSPAEPEPRAVGRTNHLSLPRFA-PVVTTPV 715
Score = 46.6 bits (109), Expect = 4e-05
Identities = 41/152 (26%), Positives = 55/152 (36%), Gaps = 34/152 (22%)
Query: 57 RKPAAGLSAAPVPTAPAAGAPLMDFGNDFV-----------------PPAPRGPLPAAPP 99
++PA S PT P+ PL + + PPAP P +PP
Sbjct: 575 QEPAPVPSPPRAPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPPPAPSPP 634
Query: 100 VAPE---------RQPSWDPSP----VSSTVPAPSPLSAAAVSPSKLPEDDEPPARPPPP 146
AP R P + PS + +V P PL A + P D+ PA P P
Sbjct: 635 PAPATSSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGAPEAPEPEPPPADDSPAEPEPR 694
Query: 147 PPASVS----PQAEPVWTPPAPAPAAPPSTPA 174
+ P+ PV T P A +P PA
Sbjct: 695 AVGRTNHLSLPRFAPVVTTPVKAEVSPHGAPA 726
Score = 43.1 bits (100), Expect = 4e-04
Identities = 35/113 (30%), Positives = 42/113 (37%), Gaps = 21/113 (18%)
Query: 57 RKPAAGLSAAPVPTA----------PAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQP 106
R+P G+S P+P+ P G P DF P R P+ P+AP P
Sbjct: 1874 RRPLGGVSFGPLPSPGSPSSLTHHIPTVGDP------DFPAPPRRSRRPS--PLAPRPPP 1925
Query: 107 SWDPSPVSSTVP---APSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAE 156
S SP T P P P S E P P PPPP + P E
Sbjct: 1926 SRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFE 1978
Score = 42.4 bits (98), Expect = 7e-04
Identities = 43/145 (29%), Positives = 60/145 (41%), Gaps = 40/145 (27%)
Query: 58 KPAAGLSAAPV-PTAPAAGAPLMDFGNDFVPPAPRGPLPAAPPVAPERQPSWDPSPVSST 116
+P+ GL+A+P PT A ++P AP + + P APE P P +S
Sbjct: 2147 QPSQGLTASPADPTRTFA----------WLPGAPGVRVLSLGP-APE-----PPKPATSK 2190
Query: 117 VPAPSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWT---------------- 160
+ + L V + E PP + PP PP ++SP A WT
Sbjct: 2191 IILVNKLGQVFVKMAGEGEPVPPPVKQPPLPP-TISPTAPTSWTLPPGPLLGVLPVVGVV 2249
Query: 161 PPAPAPAAPPST------PAAPKRR 179
PAP P PP T PA+P R+
Sbjct: 2250 RPAPPPPPPPLTLVLSSGPASPPRQ 2274
Score = 39.7 bits (91), Expect = 0.005
Identities = 43/148 (29%), Positives = 53/148 (35%), Gaps = 39/148 (26%)
Query: 68 VPTAPAAGAPLMDF-------GNDFVPPAPR---GPLPAAPPVAPERQP----SWDP--- 110
VP AP +P+ + PPAPR G P +P R+P S+ P
Sbjct: 1828 VPGAPERHSPIQNLDPPLRPDSGSAPPPAPRSFSGARIKVPNYSPSRRPLGGVSFGPLPS 1887
Query: 111 --SPVSSTVPAPSPLSAAAVSPSKLPEDDEPPA-RPPP----------------PPPASV 151
SP S T P+ +P + P A RPPP PPP SV
Sbjct: 1888 PGSPSSLTHHIPTVGDPDFPAPPRRSRRPSPLAPRPPPSRWASPPLKTSPQLRVPPPTSV 1947
Query: 152 SPQAEPV---WTPPAPAPAAPPSTPAAP 176
P PP PAP+ PP P
Sbjct: 1948 VTALTPTSGELAPPGPAPSPPPPEDLGP 1975
Score = 39.7 bits (91), Expect = 0.005
Identities = 40/120 (33%), Positives = 48/120 (40%), Gaps = 20/120 (16%)
Query: 63 LSAAPVPTAPAAGAPLM--DFGNDFVPPAPRGPLPAAPPVA-PERQPSWDPS-PVSSTVP 118
L AP P PA ++ G FV A G P PPV P P+ P+ P S T+P
Sbjct: 2177 LGPAPEPPKPATSKIILVNKLGQVFVKMAGEGE-PVPPPVKQPPLPPTISPTAPTSWTLP 2235
Query: 119 APSPLSAAAVSPSKLPEDDEPPARPPPPPPASVSPQAEPVWTPPAPAPAAPPSTPAAPKR 178
P PL LP PPPPPP P+ + PA+PP KR
Sbjct: 2236 -PGPLLGV------LPVVGVVRPAPPPPPP--------PLTLVLSSGPASPPRQAIRVKR 2280
Score = 30.0 bits (66), Expect = 3.8
Identities = 29/90 (32%), Positives = 34/90 (37%), Gaps = 9/90 (10%)
Query: 67 PVPTAPAAGAPLMDFGNDFVPPA---PRGPLPAAPPVAPERQPSWDPSP-----VSSTVP 118
PVP P PL + P + P GPL PV +P+ P P V S+ P
Sbjct: 2210 PVPP-PVKQPPLPPTISPTAPTSWTLPPGPLLGVLPVVGVVRPAPPPPPPPLTLVLSSGP 2268
Query: 119 APSPLSAAAVSPSKLPEDDEPPARPPPPPP 148
A P A V PPA PP P
Sbjct: 2269 ASPPRQAIRVKRVSTFSGRSPPAPPPYKAP 2298
Score = 29.3 bits (64), Expect = 6.4
Identities = 38/158 (24%), Positives = 53/158 (33%), Gaps = 17/158 (10%)
Query: 57 RKPAAGLSAAPVPTAPAAGAPLMDFGNDFVPP-----APRGPLPAAPPVAPERQPSWDPS 111
R P + ++ P+ T+P P + P AP GP P+ PP D
Sbjct: 1922 RPPPSRWASPPLKTSPQLRVPPPTSVVTALTPTSGELAPPGPAPSPPPPEDLGPDFEDME 1981
Query: 112 PVSSTVPAPSPLSAAAVSPSKLPED-------DEPPARPPPPPPASVSPQAE----PVWT 160
VS A +A+ + E+ P SP + PV
Sbjct: 1982 VVSGLSAADLDFAASLLGTEPFQEEIVAAGAMGSSHGGPGDSSEEESSPTSRYIHFPVTV 2041
Query: 161 PPAPAPAAPPSTPAAPKRRGSSGSVDETLFALPAASEP 198
AP AP +TP AP+ G D T A +P
Sbjct: 2042 VSAPG-LAPSATPGAPRIEQLDGVDDGTDSEAEAVQQP 2078
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.385
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,354,908
Number of Sequences: 37866
Number of extensions: 1426218
Number of successful extensions: 62690
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1585
Number of HSP's successfully gapped in prelim test: 1868
Number of HSP's that attempted gapping in prelim test: 17219
Number of HSP's gapped (non-prelim): 22042
length of query: 392
length of database: 18,247,518
effective HSP length: 104
effective length of query: 288
effective length of database: 14,309,454
effective search space: 4121122752
effective search space used: 4121122752
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.