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Search of human proteins with 47078229
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
(474 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 957 0.0
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens] 957 0.0
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens] 941 0.0
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens] 652 0.0
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens] 603 e-172
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens] 603 e-172
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens] 370 e-102
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens] 345 4e-95
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens] 329 4e-90
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 316 3e-86
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 314 1e-85
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens] 313 3e-85
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens] 311 1e-84
gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens] 247 1e-65
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens] 229 3e-60
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 225 6e-59
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 224 1e-58
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 224 1e-58
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 224 1e-58
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 224 1e-58
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof... 224 1e-58
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 224 1e-58
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 223 3e-58
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 223 3e-58
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens] 215 8e-56
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens] 215 8e-56
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens] 215 8e-56
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 213 4e-55
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1... 213 4e-55
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens] 211 1e-54
>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 957 bits (2473), Expect = 0.0
Identities = 474/474 (100%), Positives = 474/474 (100%)
Query: 1 MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST 60
MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST
Sbjct: 1 MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST 60
Query: 61 FSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDL 120
FSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDL
Sbjct: 61 FSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDL 120
Query: 121 PKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE 180
PKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE
Sbjct: 121 PKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE 180
Query: 181 EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMH 240
EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMH
Sbjct: 181 EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMH 240
Query: 241 NVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNE 300
NVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNE
Sbjct: 241 NVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNE 300
Query: 301 VVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTP 360
VVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTP
Sbjct: 301 VVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTP 360
Query: 361 TEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAAL 420
TEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAAL
Sbjct: 361 TEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAAL 420
Query: 421 SHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF 474
SHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF
Sbjct: 421 SHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF 474
>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
Length = 474
Score = 957 bits (2473), Expect = 0.0
Identities = 474/474 (100%), Positives = 474/474 (100%)
Query: 1 MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST 60
MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST
Sbjct: 1 MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST 60
Query: 61 FSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDL 120
FSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDL
Sbjct: 61 FSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDL 120
Query: 121 PKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE 180
PKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE
Sbjct: 121 PKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE 180
Query: 181 EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMH 240
EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMH
Sbjct: 181 EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMH 240
Query: 241 NVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNE 300
NVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNE
Sbjct: 241 NVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNE 300
Query: 301 VVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTP 360
VVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTP
Sbjct: 301 VVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTP 360
Query: 361 TEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAAL 420
TEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAAL
Sbjct: 361 TEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAAL 420
Query: 421 SHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF 474
SHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF
Sbjct: 421 SHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF 474
>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
Length = 504
Score = 941 bits (2432), Expect = 0.0
Identities = 474/504 (94%), Positives = 474/504 (94%), Gaps = 30/504 (5%)
Query: 1 MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST 60
MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST
Sbjct: 1 MIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECST 60
Query: 61 FSPTDSGEEPGQLSPGVQFQRRQNQRRFSME----------------------------- 91
FSPTDSGEEPGQLSPGVQFQRRQNQRRFSME
Sbjct: 61 FSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEVRASGALPRQVAGCTHKGVHRRAAALQPD 120
Query: 92 -DVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKL 150
DVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKL
Sbjct: 121 FDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKL 180
Query: 151 GEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIH 210
GEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIH
Sbjct: 181 GEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIH 240
Query: 211 TDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQN 270
TDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQN
Sbjct: 241 TDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQN 300
Query: 271 LLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 330
LLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI
Sbjct: 301 LLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 360
Query: 331 HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 390
HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH
Sbjct: 361 HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 420
Query: 391 APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQ 450
APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQ
Sbjct: 421 APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQ 480
Query: 451 KDPGYRGLAFQQPGRGKNRRQSIF 474
KDPGYRGLAFQQPGRGKNRRQSIF
Sbjct: 481 KDPGYRGLAFQQPGRGKNRRQSIF 504
>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
Length = 523
Score = 652 bits (1682), Expect = 0.0
Identities = 331/521 (63%), Positives = 394/521 (75%), Gaps = 53/521 (10%)
Query: 6 MKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPP---------Q 56
MK FKRR SL++ ++TI+ESL+E EQ N +N + GR P Q
Sbjct: 1 MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60
Query: 57 ECSTF---------------------------------------SPTDSGEEPGQLSPGV 77
+F S +S + G S V
Sbjct: 61 YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120
Query: 78 QFQ-----RRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRAS 132
Q R + RR SMED++KRLSLP DIR+P +L+KLQ+ SP +P+SR SRRAS
Sbjct: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180
Query: 133 LSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 192
LS+IGFGK+ETY+KL+KLGEGTYATV+KGRSKLTENLVALKEIRLEHEEGAPCTAIREVS
Sbjct: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240
Query: 193 LLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRG 252
LLK+LKHANIVTLHD++HTD+SLTLVFEYLD DLKQY+D CGN+MSMHNVK+F++Q+LRG
Sbjct: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300
Query: 253 LAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 312
LAYCH RK+LHRDLKPQNLLINE+GELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL
Sbjct: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360
Query: 313 LGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFS 372
LGS+EYST IDMWGVGCI +EMA+GRPLFPGSTV++ELHLIFRLLGTP++ETWPG+++
Sbjct: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420
Query: 373 EFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERV 432
EF+ Y+FP Y PQPLINHAPRLD++GI L++ L YESK R+SAE A+ H YFRSLG R+
Sbjct: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480
Query: 433 HQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSI 473
H L ++ SIFSLKEIQLQKDPG+R ++ + G GKNRRQS+
Sbjct: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETGHGKNRRQSM 521
>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
Length = 502
Score = 603 bits (1555), Expect = e-172
Identities = 297/424 (70%), Positives = 351/424 (82%), Gaps = 8/424 (1%)
Query: 42 NENLQLGPLGRDPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPM 101
+E+L++G G E S T S E SP R R+ S ED++KRLSLP
Sbjct: 77 HEDLKMGSDG-----ESDQASATSSDEVQ---SPVRVRMRNHPPRKISTEDINKRLSLPA 128
Query: 102 DIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKG 161
DIRLP+ +L+KL + SP KPLSR RR SLS+IGFGKLETY+KLDKLGEGTYATV+KG
Sbjct: 129 DIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKG 188
Query: 162 RSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEY 221
+SKLT+NLVALKEIRLEHEEGAPCTAIREVSLLK+LKHANIVTLHD+IHT++SLTLVFEY
Sbjct: 189 KSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEY 248
Query: 222 LDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKL 281
LD DLKQYLD CGN+++MHNVK+F+FQLLRGLAYCH +K+LHRDLKPQNLLINERGELKL
Sbjct: 249 LDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKL 308
Query: 282 ADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLF 341
ADFGLARAKS+PTKTYSNEVVTLWYRPPD+LLGST+YST IDMWGVGCI YEMATGRPLF
Sbjct: 309 ADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLF 368
Query: 342 PGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHL 401
PGSTV+E+LH IFR+LGTPTEETWPG+ + EF+TY++P Y + L++HAPRLD+DG L
Sbjct: 369 PGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADL 428
Query: 402 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 461
L+ LL +E ++R+SAE A+ H +F SLGER+H+L DT SIF+LKEIQLQK+ R +
Sbjct: 429 LTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMP 488
Query: 462 QPGR 465
GR
Sbjct: 489 DSGR 492
>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
Length = 496
Score = 603 bits (1555), Expect = e-172
Identities = 297/424 (70%), Positives = 351/424 (82%), Gaps = 8/424 (1%)
Query: 42 NENLQLGPLGRDPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPM 101
+E+L++G G E S T S E SP R R+ S ED++KRLSLP
Sbjct: 71 HEDLKMGSDG-----ESDQASATSSDEVQ---SPVRVRMRNHPPRKISTEDINKRLSLPA 122
Query: 102 DIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKG 161
DIRLP+ +L+KL + SP KPLSR RR SLS+IGFGKLETY+KLDKLGEGTYATV+KG
Sbjct: 123 DIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKG 182
Query: 162 RSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEY 221
+SKLT+NLVALKEIRLEHEEGAPCTAIREVSLLK+LKHANIVTLHD+IHT++SLTLVFEY
Sbjct: 183 KSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEY 242
Query: 222 LDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKL 281
LD DLKQYLD CGN+++MHNVK+F+FQLLRGLAYCH +K+LHRDLKPQNLLINERGELKL
Sbjct: 243 LDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKL 302
Query: 282 ADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLF 341
ADFGLARAKS+PTKTYSNEVVTLWYRPPD+LLGST+YST IDMWGVGCI YEMATGRPLF
Sbjct: 303 ADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLF 362
Query: 342 PGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHL 401
PGSTV+E+LH IFR+LGTPTEETWPG+ + EF+TY++P Y + L++HAPRLD+DG L
Sbjct: 363 PGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADL 422
Query: 402 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 461
L+ LL +E ++R+SAE A+ H +F SLGER+H+L DT SIF+LKEIQLQK+ R +
Sbjct: 423 LTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMP 482
Query: 462 QPGR 465
GR
Sbjct: 483 DSGR 486
>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
Length = 451
Score = 370 bits (949), Expect = e-102
Identities = 204/367 (55%), Positives = 250/367 (68%), Gaps = 23/367 (6%)
Query: 112 KLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVA 171
K + PK + R S +S + FGK ++Y KL+KLGEG+YATV+KG+SK+ LVA
Sbjct: 86 KTSSTGKESPK-VRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVA 144
Query: 172 LKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLD 231
LK IRL+ EEG P TAIRE SLLK LKHANIV LHD+IHT +LTLVFEY+ +DL QY+D
Sbjct: 145 LKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMD 204
Query: 232 HCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKS 291
+ NVK+F+FQLLRGL+Y H R ILHRDLKPQNLLI++ GELKLADFGLARAKS
Sbjct: 205 KHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKS 264
Query: 292 VPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPG-STVKEEL 350
VP+ TYSNEVVTLWYRPPDVLLGSTEYST +DMWGVGCI EM G FPG ++++L
Sbjct: 265 VPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQL 324
Query: 351 HLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPL---------INHAPRLDTDGIHL 401
IF +LGTP E+TWPGV + F+ F Y + L +NHA L
Sbjct: 325 ERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAE-------DL 377
Query: 402 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 461
S LL K+R+SA+AALSH YF L R+ +L D +SIF++ ++LQ + G AF
Sbjct: 378 ASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAF- 436
Query: 462 QPGRGKN 468
GKN
Sbjct: 437 ----GKN 439
>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
Length = 384
Score = 345 bits (886), Expect = 4e-95
Identities = 175/318 (55%), Positives = 227/318 (71%), Gaps = 3/318 (0%)
Query: 138 FGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNL 197
FG +Y+ L+KLGEG+YATV+KG S++ LVALK I + EEG P TAIRE SLLK L
Sbjct: 46 FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105
Query: 198 KHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCH 257
KHANIV LHD+IHT +LT VFEY+ +DL QY+ + HNV++FMFQLLRGLAY H
Sbjct: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165
Query: 258 HRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTE 317
H+ +LHRDLKPQNLLI+ GELKLADFGLARAKS+P++TYS+EVVTLWYRPPD LLG+TE
Sbjct: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225
Query: 318 YSTPIDMWGVGCIHYEMATGRPLFPG-STVKEELHLIFRLLGTPTEETWPGVTAFSEFRT 376
YS+ +D+WG GCI EM G+PLFPG S + E+L I+ +LG PTE+TWPGV+ +
Sbjct: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285
Query: 377 YSFPCYLPQPLINHAPRLD--TDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQ 434
FP P+ L RL + L S +L + R+SA+ AL H YF +L +++Q
Sbjct: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345
Query: 435 LEDTASIFSLKEIQLQKD 452
L D S+F++ ++L+ +
Sbjct: 346 LPDEESLFTVSGVRLKPE 363
>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
Length = 292
Score = 329 bits (843), Expect = 4e-90
Identities = 164/288 (56%), Positives = 205/288 (71%), Gaps = 5/288 (1%)
Query: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 199
++ Y KL+K+GEGTY TVFK +++ T +VALK +RL+ + EG P +A+RE+ LLK LKH
Sbjct: 1 MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60
Query: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHR 259
NIV LHD++H+D+ LTLVFE+ D DLK+Y D C + VK F+FQLL+GL +CH R
Sbjct: 61 KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120
Query: 260 KILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYS 319
+LHRDLKPQNLLIN GELKLADFGLARA +P + YS EVVTLWYRPPDVL G+ YS
Sbjct: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180
Query: 320 TPIDMWGVGCIHYEMA-TGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 378
T IDMW GCI E+A GRPLFPG+ V ++L IFRLLGTPTEE WP +T +++ Y
Sbjct: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPY- 239
Query: 379 FPCY-LPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF 425
P Y L+N P+L+ G LL +LL R+SAE AL H YF
Sbjct: 240 -PMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 316 bits (809), Expect = 3e-86
Identities = 151/298 (50%), Positives = 212/298 (71%), Gaps = 4/298 (1%)
Query: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLE-HEEGAPCTAIREVSLLKNLKH 199
+E Y K++K+GEGTY V+KGR K T +VA+K+IRLE EEG P TAIRE+SLLK L+H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHC--GNLMSMHNVKIFMFQLLRGLAYCH 257
NIV+L D++ D L L+FE+L DLK+YLD G M VK +++Q+L+G+ +CH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 258 HRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTE 317
R++LHRDLKPQNLLI+++G +KLADFGLARA +P + Y++EVVTLWYR P+VLLGS
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180
Query: 318 YSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTY 377
YSTP+D+W +G I E+AT +PLF G + ++L IFR LGTP E WP V + +++
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239
Query: 378 SFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 435
+FP + P L +H LD +G+ LLS +L+Y+ R+S + AL+H YF L ++ ++
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 314 bits (804), Expect = 1e-85
Identities = 149/298 (50%), Positives = 211/298 (70%), Gaps = 4/298 (1%)
Query: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLE-HEEGAPCTAIREVSLLKNLKH 199
+E Y K++K+GEGTY V+KGR K T +VA+K+IRLE EEG P TAIRE+SLLK L+H
Sbjct: 1 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60
Query: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHC--GNLMSMHNVKIFMFQLLRGLAYCH 257
NIV+L D++ D L L+FE+L DLK+YLD G M VK +++Q+L+G+ +CH
Sbjct: 61 PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120
Query: 258 HRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTE 317
R++LHRDLKPQNLLI+++G +KLADFGLARA +P + Y++E +TLWYR P+VLLGS
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSAR 180
Query: 318 YSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTY 377
YSTP+D+W +G I E+AT +PLF G + ++L IFR LGTP E WP V + +++
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239
Query: 378 SFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 435
+FP + P L +H LD +G+ LLS +L+Y+ R+S + AL+H YF L ++ ++
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297
>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
Length = 305
Score = 313 bits (801), Expect = 3e-85
Identities = 152/289 (52%), Positives = 213/289 (73%), Gaps = 3/289 (1%)
Query: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 199
++ + K++K+GEGTY V+K +++ T LVALK+IRL+ E EG P TAIRE+SLLK LKH
Sbjct: 1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60
Query: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHC-GNLMSMHNVKIFMFQLLRGLAYCHH 258
NIV L D++H +R L LVFE+L DLK+Y+D G+ + +H +K ++FQLL+G+++CH
Sbjct: 61 PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120
Query: 259 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 318
+++HRDLKPQNLLINE G +KLADFGLARA VP +TY++EVVTLWYR P++LLGS Y
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY 180
Query: 319 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 378
+T +D+W +GCI EM T + LFPG + ++L IFR+LGTP+E+TWPGVT +++ S
Sbjct: 181 TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG-S 239
Query: 379 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRS 427
FP + + L P L+ +G LL LL Y+ R++A+ AL+H YF S
Sbjct: 240 FPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSS 288
>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
Length = 298
Score = 311 bits (796), Expect = 1e-84
Identities = 158/297 (53%), Positives = 210/297 (70%), Gaps = 3/297 (1%)
Query: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 199
+E + K++K+GEGTY V+K R+KLT +VALK+IRL+ E EG P TAIRE+SLLK L H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLLRGLAYCHH 258
NIV L D+IHT+ L LVFE+L DLK+++D + + +K ++FQLL+GLA+CH
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 259 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 318
++LHRDLKPQNLLIN G +KLADFGLARA VP +TY++EVVTLWYR P++LLG Y
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180
Query: 319 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 378
ST +D+W +GCI EM T R LFPG + ++L IFR LGTP E WPGVT+ +++ S
Sbjct: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239
Query: 379 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 435
FP + Q P LD DG LLS +L Y+ R+SA+AAL+H +F+ + + V L
Sbjct: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 296
>gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]
Length = 264
Score = 247 bits (631), Expect = 1e-65
Identities = 138/297 (46%), Positives = 185/297 (62%), Gaps = 37/297 (12%)
Query: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKH 199
+E + K++K+GEGTY V+K R+KLT +VALK+IRL+ E EG P TAIRE+SLLK L H
Sbjct: 1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60
Query: 200 ANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLLRGLAYCHH 258
NIV L D+IHT+ L LVFE+L DLK+++D + + +K ++FQLL+GLA+CH
Sbjct: 61 PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120
Query: 259 RKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEY 318
++LHRDLKPQNLLIN G +KLADFGLARA VP +TY++EV
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV----------------- 163
Query: 319 STPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYS 378
T R LFPG + ++L IFR LGTP E WPGVT+ +++ S
Sbjct: 164 -----------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 205
Query: 379 FPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQL 435
FP + Q P LD DG LLS +L Y+ R+SA+AAL+H +F+ + + V L
Sbjct: 206 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHL 262
>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
Length = 360
Score = 229 bits (585), Expect = 3e-60
Identities = 130/328 (39%), Positives = 191/328 (58%), Gaps = 11/328 (3%)
Query: 102 DIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKG 161
D+ Q L+ ++ E P R+ R S+ + + KL+++GEGTY V++
Sbjct: 5 DLECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKE--------FEKLNRIGEGTYGIVYRA 56
Query: 162 RSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--SLTLV 218
R T+ +VALK++R++ E +G P +++RE++LL L+H NIV L +++ + S+ LV
Sbjct: 57 RDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLV 116
Query: 219 FEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGE 278
Y + DL L++ S VK + Q+LRGL Y H I+HRDLK NLL+ ++G
Sbjct: 117 MGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGC 176
Query: 279 LKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGR 338
+K ADFGLARA VP K + +VVTLWYR P++LLG+T +T IDMW VGCI E+ R
Sbjct: 177 VKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHR 236
Query: 339 PLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDG 398
PL PG++ ++ LI +LLGTP+E WPG + YS L + P L G
Sbjct: 237 PLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAG 296
Query: 399 IHLLSSLLLYESKSRMSAEAALSHSYFR 426
+ LL L +Y+ K R +A L SYF+
Sbjct: 297 LRLLHFLFMYDPKKRATAGDCLESSYFK 324
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 225 bits (574), Expect = 6e-59
Identities = 119/291 (40%), Positives = 178/291 (61%), Gaps = 8/291 (2%)
Query: 140 KLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEH----EEGAPCTAIREVSLLK 195
+ + Y KLD LGEG +ATV+K R K T +VA+K+I+L H ++G TA+RE+ LL+
Sbjct: 8 RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67
Query: 196 NLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAY 255
L H NI+ L D +++LVF+++++DL+ + +++ ++K +M L+GL Y
Sbjct: 68 ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127
Query: 256 CHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGS 315
H ILHRDLKP NLL++E G LKLADFGLA++ P + Y+++VVT WYR P++L G+
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187
Query: 316 TEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFR 375
Y +DMW VGCI E+ P PG + ++L IF LGTPTEE WP + + ++
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247
Query: 376 TY-SFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF 425
T+ SFP PL + D + L+ L L+ +R++A AL YF
Sbjct: 248 TFKSFPGI---PLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF 295
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 224 bits (572), Expect = 1e-58
Identities = 120/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 137 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 195
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 407 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 466
Query: 196 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 253
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 467 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 526
Query: 254 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 313
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++LL
Sbjct: 527 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLL 586
Query: 314 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 373
G+ EYST +DMW VGCI E+ T +PLFPG + ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 587 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG---YSE 643
Query: 374 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 426
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 644 LPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 700
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 224 bits (572), Expect = 1e-58
Identities = 120/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 137 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 195
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 416 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 475
Query: 196 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 253
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 476 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 535
Query: 254 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 313
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++LL
Sbjct: 536 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLL 595
Query: 314 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 373
G+ EYST +DMW VGCI E+ T +PLFPG + ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 596 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG---YSE 652
Query: 374 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 426
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 653 LPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 709
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 224 bits (572), Expect = 1e-58
Identities = 120/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 137 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 195
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 384 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 443
Query: 196 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 253
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 444 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 503
Query: 254 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 313
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++LL
Sbjct: 504 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLL 563
Query: 314 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 373
G+ EYST +DMW VGCI E+ T +PLFPG + ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 564 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG---YSE 620
Query: 374 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 426
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 621 LPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 677
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 224 bits (572), Expect = 1e-58
Identities = 120/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 137 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 195
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 373 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 432
Query: 196 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 253
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 433 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 492
Query: 254 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 313
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++LL
Sbjct: 493 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLL 552
Query: 314 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 373
G+ EYST +DMW VGCI E+ T +PLFPG + ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 553 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG---YSE 609
Query: 374 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 426
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 610 LPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 666
>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
3 [Homo sapiens]
Length = 526
Score = 224 bits (572), Expect = 1e-58
Identities = 120/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 137 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 195
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 162 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 221
Query: 196 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 253
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 222 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 281
Query: 254 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 313
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++LL
Sbjct: 282 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLL 341
Query: 314 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 373
G+ EYST +DMW VGCI E+ T +PLFPG + ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 342 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG---YSE 398
Query: 374 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 426
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 399 LPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 455
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 224 bits (572), Expect = 1e-58
Identities = 120/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 137 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 195
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 418 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 477
Query: 196 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 253
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 478 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 537
Query: 254 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 313
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVTLWYR P++LL
Sbjct: 538 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLL 597
Query: 314 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 373
G+ EYST +DMW VGCI E+ T +PLFPG + ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 598 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG---YSE 654
Query: 374 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 426
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 655 LPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 711
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 223 bits (568), Expect = 3e-58
Identities = 119/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 137 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 195
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 406 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 465
Query: 196 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 253
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 466 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 525
Query: 254 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 313
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVT WYR P++LL
Sbjct: 526 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLL 585
Query: 314 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 373
G+ EYST +DMW VGCI E+ T +PLFPG++ ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 586 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPG---YSE 642
Query: 374 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 426
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 643 LPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 699
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 223 bits (568), Expect = 3e-58
Identities = 119/297 (40%), Positives = 175/297 (58%), Gaps = 10/297 (3%)
Query: 137 GFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 195
G +E + L+++ EGTY V++ + K T+ +VALK +++E E EG P T++RE++ +
Sbjct: 416 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 475
Query: 196 NLKHANIVTLHDLIHTDR--SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGL 253
+H NIVT+ +++ + +V Y++ DLK ++ VK M QLLRG+
Sbjct: 476 KAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGV 535
Query: 254 AYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLL 313
+ H ILHRDLK NLL++ G LK+ DFGLAR P K Y+ VVT WYR P++LL
Sbjct: 536 KHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLL 595
Query: 314 GSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSE 373
G+ EYST +DMW VGCI E+ T +PLFPG++ ++++ +F+ LGTP+E+ WPG +SE
Sbjct: 596 GAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPG---YSE 652
Query: 374 FRTYSFPCYLPQPLINHAPR----LDTDGIHLLSSLLLYESKSRMSAEAALSHSYFR 426
+ P N R L G L++ L Y R+SAE L H YFR
Sbjct: 653 LPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 709
>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
Length = 346
Score = 215 bits (547), Expect = 8e-56
Identities = 111/288 (38%), Positives = 168/288 (58%), Gaps = 3/288 (1%)
Query: 141 LETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEH-EEGAPCTAIREVSLLKNLK- 198
++ Y L ++GEG + VFK + T +VALK++ L E+G P A+RE+ L+ ++
Sbjct: 1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMED 60
Query: 199 HANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHH 258
+ +V L + L FE++ SDL + + H ++ VK ++ LL+G+A+CH
Sbjct: 61 NQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHA 120
Query: 259 RKILHRDLKPQNLLINERGELKLADFGLARAKSVP-TKTYSNEVVTLWYRPPDVLLGSTE 317
I+HRDLKP NLLI+ G+LK+ADFGLAR S ++ Y+++V T WYR P++L G+ +
Sbjct: 121 NNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQ 180
Query: 318 YSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTY 377
Y +D+W VGCI E+ G PLFPG E+L + R+LGTP + WP +T ++
Sbjct: 181 YDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKI 240
Query: 378 SFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYF 425
SF +P PL P + + LL LLY R++A AL H YF
Sbjct: 241 SFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF 288
>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
Length = 1512
Score = 215 bits (547), Expect = 8e-56
Identities = 124/338 (36%), Positives = 186/338 (55%), Gaps = 16/338 (4%)
Query: 106 PQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGK--LETYVKLDKLGEGTYATVFKGRS 163
P+E Q+ S PK DI +GK ++ + + +GEGTY V+K R
Sbjct: 665 PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARD 724
Query: 164 KLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--------- 213
K T +VALK++RL++E EG P TAIRE+ +L+ L H +I+ + +++ TD+
Sbjct: 725 KDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIV-TDKEDALDFKKD 783
Query: 214 --SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNL 271
+ LVFEY+D DL L+ + +++K FM QL+ GL YCH + LHRD+K N+
Sbjct: 784 KGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNI 843
Query: 272 LINERGELKLADFGLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 330
L+N RG++KLADFGLAR S ++ Y+N+V+TLWYRPP++LLG Y+ ID+W GCI
Sbjct: 844 LLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCI 903
Query: 331 HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 390
E+ T +P+F + +L LI R+ G+P WP V F T + L
Sbjct: 904 LGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREE 963
Query: 391 APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSL 428
+ + L +L + R +AE AL + R +
Sbjct: 964 FVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDV 1001
>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
Length = 1452
Score = 215 bits (547), Expect = 8e-56
Identities = 124/338 (36%), Positives = 186/338 (55%), Gaps = 16/338 (4%)
Query: 106 PQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGK--LETYVKLDKLGEGTYATVFKGRS 163
P+E Q+ S PK DI +GK ++ + + +GEGTY V+K R
Sbjct: 665 PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARD 724
Query: 164 KLTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR--------- 213
K T +VALK++RL++E EG P TAIRE+ +L+ L H +I+ + +++ TD+
Sbjct: 725 KDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIV-TDKEDALDFKKD 783
Query: 214 --SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNL 271
+ LVFEY+D DL L+ + +++K FM QL+ GL YCH + LHRD+K N+
Sbjct: 784 KGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNI 843
Query: 272 LINERGELKLADFGLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCI 330
L+N RG++KLADFGLAR S ++ Y+N+V+TLWYRPP++LLG Y+ ID+W GCI
Sbjct: 844 LLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCI 903
Query: 331 HYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINH 390
E+ T +P+F + +L LI R+ G+P WP V F T + L
Sbjct: 904 LGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREE 963
Query: 391 APRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSL 428
+ + L +L + R +AE AL + R +
Sbjct: 964 FVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDV 1001
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 213 bits (541), Expect = 4e-55
Identities = 135/397 (34%), Positives = 206/397 (51%), Gaps = 23/397 (5%)
Query: 54 PPQECSTFSPTDSG-EEPGQLSPGVQFQRRQNQR-RFSMEDVSKRLSLPMDIRLPQEFLQ 111
PP P D + P + P ++ + QR R + D+ LP P + +
Sbjct: 628 PPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPE 687
Query: 112 KLQMESPDLP-KPLSRM------SRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSK 164
+ P P K ++ RR + SD G ++ + + +GEGTY V+K + K
Sbjct: 688 PKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDK 747
Query: 165 LTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR---------- 213
T LVALK++RL++E EG P TAIRE+ +L+ L H ++V + +++ TD+
Sbjct: 748 DTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIV-TDKQDALDFKKDK 806
Query: 214 -SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLL 272
+ LVFEY+D DL L+ S ++K FM QL+ GL YCH + LHRD+K N+L
Sbjct: 807 GAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNIL 866
Query: 273 INERGELKLADFGLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIH 331
+N G++KLADFGLAR S ++ Y+N+V+TLWYRPP++LLG Y+ ID+W GCI
Sbjct: 867 LNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCIL 926
Query: 332 YEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHA 391
E+ T +P+F + +L LI RL G+P WP V F T + L
Sbjct: 927 GELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEF 986
Query: 392 PRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSL 428
+ + + LL +L + R +AE L + + +
Sbjct: 987 SFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDV 1023
>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
[Homo sapiens]
Length = 1490
Score = 213 bits (541), Expect = 4e-55
Identities = 135/397 (34%), Positives = 206/397 (51%), Gaps = 23/397 (5%)
Query: 54 PPQECSTFSPTDSG-EEPGQLSPGVQFQRRQNQR-RFSMEDVSKRLSLPMDIRLPQEFLQ 111
PP P D + P + P ++ + QR R + D+ LP P + +
Sbjct: 628 PPLPLPPLLPGDDDMDSPKETLPSKPVKKEKEQRTRHLLTDLPLPPELPGGDLSPPDSPE 687
Query: 112 KLQMESPDLP-KPLSRM------SRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSK 164
+ P P K ++ RR + SD G ++ + + +GEGTY V+K + K
Sbjct: 688 PKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDK 747
Query: 165 LTENLVALKEIRLEHE-EGAPCTAIREVSLLKNLKHANIVTLHDLIHTDR---------- 213
T LVALK++RL++E EG P TAIRE+ +L+ L H ++V + +++ TD+
Sbjct: 748 DTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIV-TDKQDALDFKKDK 806
Query: 214 -SLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLL 272
+ LVFEY+D DL L+ S ++K FM QL+ GL YCH + LHRD+K N+L
Sbjct: 807 GAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNIL 866
Query: 273 INERGELKLADFGLARA-KSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIH 331
+N G++KLADFGLAR S ++ Y+N+V+TLWYRPP++LLG Y+ ID+W GCI
Sbjct: 867 LNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCIL 926
Query: 332 YEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHA 391
E+ T +P+F + +L LI RL G+P WP V F T + L
Sbjct: 927 GELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEF 986
Query: 392 PRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSL 428
+ + + LL +L + R +AE L + + +
Sbjct: 987 SFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDV 1023
>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
Length = 326
Score = 211 bits (537), Expect = 1e-54
Identities = 130/298 (43%), Positives = 177/298 (59%), Gaps = 16/298 (5%)
Query: 142 ETYVKLDKLGEGTYATVFKGRS-KLTENLVALKEIRLEH-EEGAPCTAIREVSLLKNLK- 198
+ Y + ++GEG Y VFK R K VALK +R++ EEG P + IREV++L++L+
Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70
Query: 199 --HANIVTLHDLI---HTDRS--LTLVFEYLDSDLKQYLDHCGNL-MSMHNVKIFMFQLL 250
H N+V L D+ TDR LTLVFE++D DL YLD + +K MFQLL
Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130
Query: 251 RGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPD 310
RGL + H +++HRDLKPQN+L+ G++KLADFGLAR S ++ VVTLWYR P+
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRAPE 189
Query: 311 VLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTA 370
VLL S+ Y+TP+D+W VGCI EM +PLF GS+ ++L I ++G P EE WP A
Sbjct: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248
Query: 371 FSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSL 428
+F QP+ +D G LL L + R+SA +ALSH YF+ L
Sbjct: 249 LPR---QAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,783,687
Number of Sequences: 37866
Number of extensions: 906397
Number of successful extensions: 4390
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 728
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 2306
Number of HSP's gapped (non-prelim): 927
length of query: 474
length of database: 18,247,518
effective HSP length: 106
effective length of query: 368
effective length of database: 14,233,722
effective search space: 5238009696
effective search space used: 5238009696
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.