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Search of human proteins with 46593000
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens]
(625 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens] 1186 0.0
gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens] 1115 0.0
gi|210032790 hypothetical protein LOC27146 [Homo sapiens] 108 1e-23
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 107 3e-23
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 105 1e-22
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 105 1e-22
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 105 1e-22
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 105 1e-22
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 105 2e-22
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 104 2e-22
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 104 2e-22
gi|21735548 centrosomal protein 2 [Homo sapiens] 103 4e-22
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 100 5e-21
gi|71061468 centromere protein E [Homo sapiens] 100 7e-21
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 99 9e-21
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 99 9e-21
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 99 9e-21
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 99 9e-21
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 99 9e-21
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 99 9e-21
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 99 9e-21
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 99 9e-21
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 99 9e-21
gi|148746195 trichohyalin [Homo sapiens] 99 1e-20
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 99 2e-20
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 99 2e-20
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 99 2e-20
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 99 2e-20
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 98 3e-20
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 97 3e-20
>gi|46593000 GRIP1 associated protein 1 isoform 2 [Homo sapiens]
Length = 625
Score = 1186 bits (3067), Expect = 0.0
Identities = 625/625 (100%), Positives = 625/625 (100%)
Query: 1 MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS
Sbjct: 1 MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
Query: 61 KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQG 120
KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQG
Sbjct: 61 KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQG 120
Query: 121 DPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE 180
DPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE
Sbjct: 121 DPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE 180
Query: 181 KLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLA 240
KLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLA
Sbjct: 181 KLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLA 240
Query: 241 ELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT 300
ELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT
Sbjct: 241 ELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT 300
Query: 301 QELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE 360
QELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE
Sbjct: 301 QELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE 360
Query: 361 QLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYEREL 420
QLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYEREL
Sbjct: 361 QLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYEREL 420
Query: 421 RELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAE 480
RELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAE
Sbjct: 421 RELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAE 480
Query: 481 GKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLH 540
GKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLH
Sbjct: 481 GKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLH 540
Query: 541 LERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREK 600
LERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREK
Sbjct: 541 LERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREK 600
Query: 601 ESSAVPARVRGKEEPTAPASLNPKI 625
ESSAVPARVRGKEEPTAPASLNPKI
Sbjct: 601 ESSAVPARVRGKEEPTAPASLNPKI 625
>gi|46592991 GRIP1 associated protein 1 isoform 1 [Homo sapiens]
Length = 841
Score = 1115 bits (2884), Expect = 0.0
Identities = 612/704 (86%), Positives = 615/704 (87%), Gaps = 82/704 (11%)
Query: 1 MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS
Sbjct: 1 MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
Query: 61 KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSK------------------ 102
KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSK
Sbjct: 61 KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQMEQLEQENQQLKEG 120
Query: 103 -----------------------------------ERYGKEAGKFSAVSEGQGDPPGGPA 127
ERYGKEAGKFSAVSEGQGDPPGGPA
Sbjct: 121 AAGAGVAQAGPLVDGELLRLQAENTALQKNVAALQERYGKEAGKFSAVSEGQGDPPGGPA 180
Query: 128 PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE 187
PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE
Sbjct: 181 PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE 240
Query: 188 SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQ 247
SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQ
Sbjct: 241 SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQ 300
Query: 248 GERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLR 307
GERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLR
Sbjct: 301 GERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLR 360
Query: 308 EQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ 367
EQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ
Sbjct: 361 EQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ 420
Query: 368 EARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDK 427
EARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDK
Sbjct: 421 EARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDK 480
Query: 428 KRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAE------- 480
KRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAE
Sbjct: 481 KRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQ 540
Query: 481 -------------------GKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQ 521
GKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQ
Sbjct: 541 QEQEEALKQCREQHAAELKGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQ 600
Query: 522 RILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ 581
RILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ
Sbjct: 601 RILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ 660
Query: 582 TGDSSSISSFSYREILREKESSAVPARVRG---KEEPTAPASLN 622
TGDSSSISSFSYREILREKESSAVPAR + +P PA L+
Sbjct: 661 TGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPPRPAELS 704
Score = 35.4 bits (80), Expect = 0.16
Identities = 50/232 (21%), Positives = 97/232 (41%), Gaps = 22/232 (9%)
Query: 32 RKNGVELTSLRQKVAYLDKEFSKAQKAL------SKSKKAQEVEVLLSENEMLQAKLHSQ 85
+K L L++++ K K Q+ L SKS+ E E++LSE + + +Q
Sbjct: 605 KKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE-ELVLSE---MNSPSRTQ 660
Query: 86 EEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEM 145
D +S E +E+ S S Q PP P L+ +AE+ +
Sbjct: 661 TGDSSSISSFSYREILREKESSAVPARSLSSSPQAQPP---RPAELSDEEVAELFQRLAE 717
Query: 146 EKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL--KKKQESFCRLQTEKETLFNDS 203
++EK +L E+++ LE S + L + A + + + S T++ L +
Sbjct: 718 TQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVL 777
Query: 204 RN-------KIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQG 248
R+ + E+ ++ + + QL + L +++E +Q + L + G
Sbjct: 778 RDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKECVG 829
>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
Length = 1060
Score = 108 bits (270), Expect = 1e-23
Identities = 151/648 (23%), Positives = 281/648 (43%), Gaps = 108/648 (16%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQ 66
+E Q + QL E R N +L +K G +L + ++ + ++ A+ K++
Sbjct: 294 KERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAM-KTELVS 352
Query: 67 EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGP 126
E +VL EN++ LH Q++ L+ M + + KEA SA +E
Sbjct: 353 ENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEA---SAETEYMKQQYEED 409
Query: 127 APTVLAPMPLAEVELKWEMEKEEKRLLWE---QLQGLESSKQAETSRLQEEL-AKLSEKL 182
+ + LK ++ K + L+ + +++ + SS +AE +LQ E+ A+L E
Sbjct: 410 LRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVR 469
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAEL 242
KK ++ +L+ EK L +N + E+ + +E + + T + E Q + L
Sbjct: 470 KKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSIL 529
Query: 243 RDQRQGERLEHAAAL-RALQDQVSIQ---SADAQEQVEGLLAENNALRTSLAALEQIQTA 298
Q +L+ + QD+++ + S+D +E+ + LL E + + L +L + +T+
Sbjct: 530 ETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKEKTS 589
Query: 299 KTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQE 358
K Q L + Q Q+A+ + + Q Q + R + + L+QL ++ E
Sbjct: 590 KIQRLE----------EDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDL--E 637
Query: 359 KEQLTQELQEARKSAEKRKAMLDELAMETLQ--EKSQH-----------KEELGAVRLRH 405
+E+L +ELQE + KA L+ L+ EK++H KE +++++H
Sbjct: 638 REKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQH 697
Query: 406 EKEVLGVRARYERELRELHEDKKRQE-------EELRGQIREEKA----RTRELETLQQT 454
+ L ++A E+ +EL E+++R + E LR ++ E++A ++LE LQ
Sbjct: 698 QTHRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEALQAE 757
Query: 455 VEEL-------------------------QAQVHSMDGAKG---------WFE------- 473
+ L Q S GA G W E
Sbjct: 758 LRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGLWEENAQLQDA 817
Query: 474 -RRLK-EAEGKEEELQDVRDQ---LEQAQEERDCHLKTISSLKQE--------VKDTVDG 520
RRL+ E E ++E Q +RDQ LE+ Q+ + + + +L+QE V D
Sbjct: 818 VRRLRAEVEQHQQEAQKLRDQRRFLEETQQAQ--RAREVETLRQEHRKEMQAMVADFSSA 875
Query: 521 QRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEE 568
Q L+ A L L+ +L ++ K R +D+ + ++ L+E
Sbjct: 876 QAQLQ----ARLAALEAELKDSGEKPGKGASRPEDLQLIGRLQTRLKE 919
Score = 72.8 bits (177), Expect = 9e-13
Identities = 128/551 (23%), Positives = 234/551 (42%), Gaps = 82/551 (14%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK---AQKALSKS 62
+EEE + ++ QL++ +L D ++K+ VE+ S+R V K+ + AQ +
Sbjct: 417 TEEEKKHLKDQLVK------RLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRK 470
Query: 63 KKAQEVEVLLSENEMLQAKLHS------QEEDFRLQNSTLM--AEFSKERYGKEAGKFSA 114
K +E++ L E L KL + + E+F QN T AE S + G++
Sbjct: 471 KSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILE 530
Query: 115 VSE-----GQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWE-------------- 155
+ + P G LA AE + E+ K LL E
Sbjct: 531 TQDPCLKLDETSPRGEEYQDKLA----AEEGTSSDEEERTKVLLKEGSDPQPPLGSLLKE 586
Query: 156 ---QLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIE-ELQ 211
++Q LE Q++ ++LQ +++++ + L++ ++ + L + R K++ ELQ
Sbjct: 587 KTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQ 646
Query: 212 QRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADA 271
+ + +H ++ +LEA++Q + ++ + + L+ + S+Q
Sbjct: 647 ETTQQNHA--------MKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQIQHQ 698
Query: 272 QEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQK 331
++E E A + E++Q + L LR+ EL +QQA G +
Sbjct: 699 THRLELQALEEKARQELQEERERMQAQQALLLESLRQ-------ELSEQQAA---CSGHQ 748
Query: 332 DDLNSQLQESLRANSRLLEQLQEIGQEKEQ-LTQELQEARKSAEKRKAMLDELAMETLQE 390
DL + LQ LRA R Q G K+ + E + A + + E
Sbjct: 749 KDLEA-LQAELRALGRQQASSQCPGDSKDHIIATEERGGPGQAGSPPGAAGQGSGEGCGL 807
Query: 391 KSQHKEELGAV-RLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELE 449
++ + AV RLR E E ++++E ++L + ++ EE + Q R RE+E
Sbjct: 808 WEENAQLQDAVRRLRAEVE------QHQQEAQKLRDQRRFLEETQQAQ------RAREVE 855
Query: 450 TL-QQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTIS 508
TL Q+ +E+QA V A+ + RL E EL+D ++ + R L+ I
Sbjct: 856 TLRQEHRKEMQAMVADFSSAQAQLQARLAALEA---ELKDSGEKPGKG-ASRPEDLQLIG 911
Query: 509 SLKQEVKDTVD 519
L+ +K+ D
Sbjct: 912 RLQTRLKERED 922
Score = 64.7 bits (156), Expect = 2e-10
Identities = 125/618 (20%), Positives = 257/618 (41%), Gaps = 50/618 (8%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
+AL E + +Q + E + Q + E +L Q++ L+ + QK L++
Sbjct: 64 EALREAHQEELQNAVAETKARLLQ-----EQGCAEEEALLQRIQALESAL-ELQKRLTEE 117
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
A+ L E + ++ ++ + L S M E + + S + QG
Sbjct: 118 ALAESASCRLETKER-ELRVEAEHAERVLTLSREMLELKADYERRLQHLTSHEATPQGRL 176
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
P T P E++ E+ E +RL E Q L + LQ + +E +
Sbjct: 177 PQESPETKSEPGQGPEMQ---EVLLEVQRLRVENQQ-LSKDYARKAEELQATYERENEAI 232
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAEL 242
++ + Q+ + L+ + K +L++ + A A+ +KL+ +LE + +++L
Sbjct: 233 RQAMQ-----QSVSQALWQ-WQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGRKISDL 286
Query: 243 RD--QRQGERLEHA-AALRALQDQVSIQSADAQEQVEGL-LAENNALRTSLAALEQIQTA 298
+ Q+ ER++ L+ + + S A++ E L +A++ + +Q
Sbjct: 287 KKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAM 346
Query: 299 KTQ---ELNMLREQTTGLAAEL--QQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQ 353
KT+ E +LRE+ A L QQ Q+ ++ K + Q ++ A + +
Sbjct: 347 KTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYM---- 402
Query: 354 EIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQE-KSQHKEELGAVRLRHEKEVLGV 412
K+Q ++L++ + E+ K L + ++ L++ +H E+ +VR E E
Sbjct: 403 -----KQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAE---- 453
Query: 413 RARYERELR-ELHEDKKRQEEELRGQIREEKA------RTRELETLQQTVEELQAQVHSM 465
R + +RE+ +L E +K+ E+E++ Q+ EEKA + LE L+ +EE Q +
Sbjct: 454 RKKLQREVEAQLEEVRKKSEKEIK-QLEEEKAALNVKLQNSLLEVLR--LEEFIQQNKTR 510
Query: 466 DGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE 525
+ L E QD +L++ + + +++ + D + ++L
Sbjct: 511 PTGAEESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLL 570
Query: 526 KKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDS 585
K+GS L L + + +L+E Q +++ + L + S R
Sbjct: 571 KEGSDPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQAL 630
Query: 586 SSISSFSYREILREKESS 603
+S ++ RE + +
Sbjct: 631 KQLSDLEREKLQRELQET 648
Score = 52.0 bits (123), Expect = 2e-06
Identities = 60/259 (23%), Positives = 115/259 (44%), Gaps = 13/259 (5%)
Query: 309 QTTGLAAELQQQQAEYEDLM-GQKDDLNSQLQESLRANSRLLEQLQEIG-QEKEQLTQEL 366
Q T + L +Q E E M ++ +LQ ++ L LQE G E+E L Q +
Sbjct: 44 QLTKVIYALNTRQDEAEASMEALREAHQEELQNAVAETKARL--LQEQGCAEEEALLQRI 101
Query: 367 QEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH-------EKEVLGVRARYERE 419
Q + E +K + +E E+ + + KE V H +E+L ++A YER
Sbjct: 102 QALESALELQKRLTEEALAESASCRLETKERELRVEAEHAERVLTLSREMLELKADYERR 161
Query: 420 LRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQ-AQVHSMDGAKGWFERRLKE 478
L+ L + + L + E K+ + +Q+ + E+Q +V + +K + + +
Sbjct: 162 LQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYARKAEEL 221
Query: 479 AEGKEEELQDVRDQLEQAQEERDCH-LKTISSLKQEVKDTVDGQRILEKKGSAALKDLKR 537
E E + +R ++Q+ + + S L++ + + +K L+ R
Sbjct: 222 QATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEHRGR 281
Query: 538 QLHLERKRADKLQERLQDI 556
++ +K A KL+ER+QD+
Sbjct: 282 KISDLKKYAQKLKERIQDL 300
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 107 bits (267), Expect = 3e-23
Identities = 145/641 (22%), Positives = 274/641 (42%), Gaps = 104/641 (16%)
Query: 3 QALSEE-EFQRMQAQLLELRTNNY-----QLSDELRKNGVELTSLRQKVAYLDKEFSKAQ 56
+ L EE E +R E + ++Y +LS+ L + G ++ + + EF K +
Sbjct: 1117 EELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLR 1176
Query: 57 KALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVS 116
+ L ++ E V + + E+ LQ E K + E S+
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM 1236
Query: 117 EGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELA 176
E L ++ E + E R E++Q S + SRLQ E
Sbjct: 1237 ESVSKSKAN----------LEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG 1286
Query: 177 KLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEAD-----------HKAQLART 225
+LS +L++K+ +L K+ + +L++ +A H L R
Sbjct: 1287 ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLRE 1346
Query: 226 Q---------KLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE 276
Q +LQ+ L AN +A+ R + + + ++ L + +++ + D++EQVE
Sbjct: 1347 QYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVE 1406
Query: 277 GLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ------ 330
+ NA SL +Q + ++L + E+ LAA L ++Q ++ ++ +
Sbjct: 1407 AV----NAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCE 1462
Query: 331 --KDDLNSQLQESLRANSRL----------LEQLQEIGQEKEQLTQE------------- 365
+ +L + L+ES ++ L L+QL+ + +E + L QE
Sbjct: 1463 ESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGK 1522
Query: 366 ----LQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELR 421
L+++RK E KA + +LA+E + +H+E A LR + E+ V++ +R++
Sbjct: 1523 TIHELEKSRKQIELEKADI-QLALEEAEAALEHEE---AKILRIQLELTQVKSEIDRKIA 1578
Query: 422 ELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEG 481
E ++EE+ Q++ RT +ET+Q L A+V S + A R K+ EG
Sbjct: 1579 E-------KDEEIE-QLKRNYQRT--VETMQSA---LDAEVRSRNEAI----RLKKKMEG 1621
Query: 482 KEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHL 541
+L ++ QL A + LK + S++ ++KDT ++ +DLK QL +
Sbjct: 1622 ---DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDT----QLHLDDALRGQEDLKEQLAI 1674
Query: 542 ERKRADKLQERLQDILTNSKSRSGLEELVLSE-MNSPSRTQ 581
+RA+ LQ ++++ + +L E ++S R Q
Sbjct: 1675 VERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQ 1715
Score = 94.0 bits (232), Expect = 4e-19
Identities = 123/529 (23%), Positives = 236/529 (44%), Gaps = 58/529 (10%)
Query: 43 QKVAYLDKEFSKAQKALSKSK-KAQEVE----VLLSENEMLQAKLHSQEEDFRLQNSTLM 97
+++A + +EF K + L+KS+ K +E+E L+ E LQ ++ ++ E+ L
Sbjct: 848 KEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENL-LDAEERC 906
Query: 98 AEFSKERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQL 157
+ K ++ EA K V+E D A L + K E E E + + L
Sbjct: 907 DQLIKAKFQLEA-KIKEVTERAEDEEEINAE-------LTAKKRKLEDECSELKKDIDDL 958
Query: 158 QGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEAD 217
+ + + E + ++ L+E+L E+ +L EK+ L + +++LQ E D
Sbjct: 959 ELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQA--EED 1016
Query: 218 HKAQLARTQ-KLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE 276
L +T+ KL+Q++E SL +Q + R++ R L+ + + AQE +
Sbjct: 1017 KVNSLNKTKSKLEQQVEDLESSL----EQEKKLRVDLERNKRKLEGDLKL----AQESIL 1068
Query: 277 GLLAENNALRTSLAALE----QIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKD 332
L + L L + Q+Q+ K ++ EQT GL Q Q + ++L + +
Sbjct: 1069 DLENDKQQLDERLKKKDFEYCQLQS-KVED-----EQTLGL-----QFQKKIKELQARIE 1117
Query: 333 DLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEAR-------KSAEKRKAMLDELAM 385
+L +++ ++ +Q + +E E+L++ L+EA + +KR+A +L
Sbjct: 1118 ELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRR 1177
Query: 386 ETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKART 445
+ + QH+ + A+R +H V EL E ++ +R +++L + E K
Sbjct: 1178 DLEEATLQHEAMVAALRKKHADSVA--------ELGEQIDNLQRVKQKLEKEKSEFKLEI 1229
Query: 446 RELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLK 505
+L + ++V + +A + + E +L EA GK EE+Q +L +
Sbjct: 1230 DDLSSSMESVSKSKANLEKICRT---LEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG 1286
Query: 506 TISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 554
+S +E + V ++ + ++LKRQL E K + L LQ
Sbjct: 1287 ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQ 1335
Score = 90.1 bits (222), Expect = 5e-18
Identities = 125/572 (21%), Positives = 245/572 (42%), Gaps = 74/572 (12%)
Query: 1 MAQAL--SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKA 58
+AQ L SEE+ + + A+ L +L E+ V++ A LDK+ K
Sbjct: 1394 LAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKV 1453
Query: 59 LSKSK-----KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFS 113
L++ K E+E L E+ L +L F+L+N+ A E +E
Sbjct: 1454 LAEWKTKCEESQAELEASLKESRSLSTEL------FKLKNAYEEALDQLETVKRENKNLE 1507
Query: 114 AVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQE 173
+ T+ L + + E+EK + +L E+ + ++A+ R+Q
Sbjct: 1508 QEIADLTEQIAENGKTI---HELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQL 1564
Query: 174 EL----AKLSEKLKKKQESFCRLQTEKETLFNDSRNKIE-ELQQRKEADH--KAQLARTQ 226
EL +++ K+ +K E +L+ + ++ ++ E++ R EA K
Sbjct: 1565 ELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLN 1624
Query: 227 KLQQELEAANQSLAE-------LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 279
+++ +L AN+ AE ++ Q + +L ALR Q+ + Q A + + L
Sbjct: 1625 EIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRG-QEDLKEQLAIVERRANLLQ 1683
Query: 280 AENNALRTSLAALEQIQTAKTQEL-------NMLREQTTGLA-------AELQQQQAEYE 325
AE LR +L E+ + QEL +L Q T L +L Q Q+E E
Sbjct: 1684 AEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVE 1743
Query: 326 DLMGQKDDLNSQLQESLRANSRLLEQL---QEIGQEKEQLTQELQEARKSAEKRKAMLDE 382
D + + ++++ + + E+L Q+ E++ + L++ K + R ++
Sbjct: 1744 DASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1803
Query: 383 LAMETLQEKSQHKE--------ELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEEL 434
LA++ +++ Q E EL + ++ + V G+R +YER ++EL + EE+
Sbjct: 1804 LALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLR-KYERRVKEL---TYQSEEDR 1859
Query: 435 RGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLE 494
+ +R LQ V++LQ +V S K E ++A + + + +LE
Sbjct: 1860 KNVLR-----------LQDLVDKLQVKVKSY---KRQAEEADEQANAHLTKFRKAQHELE 1905
Query: 495 QAQEERDCHLKTISSLKQEVKDTVDGQRILEK 526
+A+E D ++ L+ + +D + ++ +
Sbjct: 1906 EAEERADIAESQVNKLRAKTRDFTSSRMVVHE 1937
Score = 80.1 bits (196), Expect = 6e-15
Identities = 150/681 (22%), Positives = 280/681 (41%), Gaps = 136/681 (19%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEF-------SKAQKAL 59
EE + +A + LR + EL + L ++QK+ EF S + +++
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV 1239
Query: 60 SKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQ 119
SKSK E E+++ +A+ ++E +Q S K R EAG+ S E +
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKNEE----IQRSLSELTTQKSRLQTEAGELSRQLEEK 1295
Query: 120 GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSK------QAETSRLQE 173
+ + A E ELK ++E+E K L+SS+ + + QE
Sbjct: 1296 ESIVSQLSRSKQAFTQQTE-ELKRQLEEENKAKN-ALAHALQSSRHDCDLLREQYEEEQE 1353
Query: 174 ELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELE 233
A+L L K + +T+ ET D+ + EEL++ K K R Q ++++E
Sbjct: 1354 GKAELQRALSKANSEVAQWRTKYET---DAIQRTEELEEAK----KKLAQRLQDSEEQVE 1406
Query: 234 AANQSLAEL---RDQRQGE------RLEHAAALRALQDQVS-----------IQSADAQE 273
A N A L + + QGE +E A +L A D+ + ++Q
Sbjct: 1407 AVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQA 1466
Query: 274 QVEGLLAENNALRTSL--------AALEQIQTAKTQELNM------LREQTTGLAAELQQ 319
++E L E+ +L T L AL+Q++T K + N+ L EQ + +
Sbjct: 1467 ELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHE 1526
Query: 320 QQAEYEDLMGQKDDLNSQLQESLRA----NSRLLEQLQEIGQEKEQLTQELQEARKSAEK 375
+ + + +K D+ L+E+ A +++L E+ Q K ++ +++ E + E+
Sbjct: 1527 LEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQ 1586
Query: 376 RKAMLDELAMETLQE---------------KSQHKEELGAV--RLRHEKEVLGVRARYER 418
K +ET+Q K + + +L + +L H ++ R
Sbjct: 1587 LKRNYQR-TVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLR 1645
Query: 419 ELR-ELHEDKKRQEEELRGQ--IREEKART-RELETLQQTVEELQAQVHSMDGAKGWFER 474
++ +L + + ++ LRGQ ++E+ A R LQ VEEL+A + + A+ E+
Sbjct: 1646 SVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQ 1705
Query: 475 RLKEAEGK------------------EEELQDVRDQLEQA-------------------- 496
L ++ + E +L ++ ++E A
Sbjct: 1706 ELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAM 1765
Query: 497 -------QEERDCHLKTIS-SLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADK 548
+++ HL+ + +L+Q VKD Q L++ ALK K+Q+ R +
Sbjct: 1766 MAEELKKEQDTSAHLERMKKNLEQTVKDL---QHRLDEAEQLALKGGKKQIQKLETRIRE 1822
Query: 549 LQERLQ-DILTNSKSRSGLEE 568
L+ L+ + N++S GL +
Sbjct: 1823 LEFELEGEQKKNTESVKGLRK 1843
Score = 47.8 bits (112), Expect = 3e-05
Identities = 56/239 (23%), Positives = 114/239 (47%), Gaps = 32/239 (13%)
Query: 350 EQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR---LRHE 406
E +E+ KE+ + E KS KRK L+E + +QEK+ + ++ A L E
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKRKE-LEEKLVTLVQEKNDLQLQVQAESENLLDAE 903
Query: 407 K---EVLGVRARYERELRELHEDKKRQEEELRGQIREEKAR--------TRELETLQQTV 455
+ +++ + + E +++E+ E + EEE+ ++ +K + ++++ L+ T+
Sbjct: 904 ERCDQLIKAKFQLEAKIKEVTE-RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 962
Query: 456 EELQAQVHS-----------MDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHL 504
+++ + H+ + G + +E + +E Q D L+ +++ +
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLN 1022
Query: 505 KTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSR 563
KT S L+Q+V+D ++ EKK L+ KR+L + K A QE + D L N K +
Sbjct: 1023 KTKSKLEQQVED-LESSLEQEKKLRVDLERNKRKLEGDLKLA---QESILD-LENDKQQ 1076
Score = 35.4 bits (80), Expect = 0.16
Identities = 40/183 (21%), Positives = 76/183 (41%), Gaps = 12/183 (6%)
Query: 414 ARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFE 473
A E+E+ + E+ ++ ++EL + K +L TL Q +LQ QV +
Sbjct: 844 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAE-------S 896
Query: 474 RRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALK 533
L +AE + ++L + QLE +E + + E+ +R LE + S K
Sbjct: 897 ENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAEL---TAKKRKLEDECSELKK 953
Query: 534 DLKRQLHLERKRADKLQERLQDILTN-SKSRSGLEELVLSEMNSPSRTQTGDSSSISSFS 592
D+ L L + +K + ++ + N ++ SGL+E + Q ++
Sbjct: 954 DID-DLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQ 1012
Query: 593 YRE 595
E
Sbjct: 1013 AEE 1015
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 105 bits (263), Expect = 1e-22
Identities = 153/707 (21%), Positives = 293/707 (41%), Gaps = 123/707 (17%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLD-KEFSKAQKALSKSKKA 65
E + Q +Q++ + +L+D++ K E+ S+ + + K A+ S S +
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 66 QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE--AGKFSAVSEGQGDPP 123
Q+ + LL E + + ++ + ++L + +E K+ S ++ D
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 124 GGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEEL-------- 175
L E + +++ E E +E+ + +RLQ+EL
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 176 --AKLSEKLKKKQESFCRLQTEKETL---FNDSRNKIEELQQRKEA-------------D 217
+L L+KKQ F +L E++ + + D R++ E + KE +
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 218 HKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEG 277
K +L RT K+ L+A + L +D E + RAL+ Q+ +E +
Sbjct: 1498 AKEELERTNKM---LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 278 LLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYED----------- 326
L A +A ++ ++ ++L EQ +LQ+Q EYE
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 327 -------LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEK---- 375
L G DL Q +++ ++QL+++ + + +EL++AR S ++
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 376 -----RKAMLDELAMETLQE---------------KSQHKEEL-----GAVRLRHEKEVL 410
+KA E + LQE K + EEL G L+ EK L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 411 GVR-ARYERELRELHEDKK----------RQEEELRGQIREEKARTRELETLQQTVE--- 456
R A+ E EL E + + +Q E+L ++ E++ ++ E+ +Q +E
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 457 -ELQAQVHSMDGA-KGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEV 514
EL++++H M+GA K F+ + E K +L++ Q+EQ E+ K++ +++
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE---QVEQEAREKQAATKSLKQKDKKL 1851
Query: 515 KDTV----DGQRILEK------KGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRS 564
K+ + D +++ E+ KG+A +K LKRQL ++ +E Q I N +
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-------EEAEEESQRINANRRKL- 1903
Query: 565 GLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARVRG 611
+ L E + + +++ S ++ R E+S VP+R G
Sbjct: 1904 ---QRELDEATESNEAMGREVNALKS----KLRRGNETSFVPSRRSG 1943
Score = 95.9 bits (237), Expect = 1e-19
Identities = 130/606 (21%), Positives = 255/606 (42%), Gaps = 85/606 (14%)
Query: 8 EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
E+ +QAQ+ EL+ + +EL+ +A LD E ++ AL KK +E
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQA----------ALARLDDEIAQKNNAL---KKIRE 1115
Query: 68 VEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGPA 127
+E +S+ LQ L S+ + AE K G+E E D
Sbjct: 1116 LEGHISD---LQEDLDSERA------ARNKAEKQKRDLGEELEALKTELEDTLDSTA--- 1163
Query: 128 PTVLAPMPLAEVELKWEMEKEE---KRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKK 184
+ EL+ + E+E K+ L E+ + E+ Q + + + +L+E+L++
Sbjct: 1164 ---------TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 185 KQESFCRLQTEKETLFNDSRNKIEEL----QQRKEADHKAQL--ARTQKLQQELEAANQS 238
+ + L K+TL ++ + EL Q ++E +HK + A+ Q+LQ + ++
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274
Query: 239 LAELRD-----QRQGERLE------HAAALRALQDQVSIQSA--DAQEQVEGLLAENNAL 285
AEL D Q + E + A++ +D S+ S D QE ++ + +
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 345
T L LE+ + + +L+ E L + + D + D S ++
Sbjct: 1335 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1394
Query: 346 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME---------TLQEKSQHKE 396
R ++++ + Q+ E+ + K+ + + LD+L ++ L++K + +
Sbjct: 1395 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 397 ELGAVRLRHEKEVLGVRARYERELRELH----------EDKKRQEEELRGQIREEKARTR 446
+L A + R R E E RE E+ +EEL R K
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE---RTNKMLKA 1511
Query: 447 ELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKT 506
E+E L + +++ VH ++ +K E +++E + + EEL+D E A+ + +++
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ- 1570
Query: 507 ISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLH-LERKRADKLQERLQDILTNSKSRSG 565
+LK + + + + +++ + L+RQLH E + D+ ++R K
Sbjct: 1571 --ALKGQFERDLQAR---DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 566 LEELVL 571
L++L L
Sbjct: 1626 LKDLEL 1631
Score = 90.1 bits (222), Expect = 5e-18
Identities = 132/601 (21%), Positives = 255/601 (42%), Gaps = 97/601 (16%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYL------DKEFSKAQKA 58
L+ + F + Q QL ++ + L+ + L KV L ++E +
Sbjct: 801 LARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDE 860
Query: 59 LSKSKKAQEVEVLLSENEMLQAKL-HSQ-EEDFRLQNSTLMAEFSKERYGKEAGKFSAVS 116
L K+K+ Q+ +ENE+ + + HSQ E+ L L AE E Y +
Sbjct: 861 LQKTKERQQK----AENELKELEQKHSQLTEEKNLLQEQLQAE--TELYAE--------- 905
Query: 117 EGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELA 176
A + + + EL+ + + E RL E+ +G + QAE ++ +++
Sbjct: 906 ----------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL--QAERKKMAQQML 953
Query: 177 KLSEKLKKKQESFCRLQTEKET-------------LFNDSRNKIEELQQRKEADHKAQLA 223
L E+L++++ + +LQ EK T + +D NK+ + +RK + +
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK--ERKLLEERISDL 1011
Query: 224 RTQKLQQELEAAN--------QSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQV 275
T ++E +A N +S+ + R + + L L+ ++ ++D EQ+
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 276 EGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLN 335
L A+ L+ LA K +EL + A+ + +L G DL
Sbjct: 1072 ADLQAQIAELKMQLA-------KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124
Query: 336 SQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHK 395
L A ++ +Q +++G+E E L EL++ S A EL + QE + K
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST----ATQQELRAKREQEVTVLK 1180
Query: 396 EELGAVRLRHEKEVLGVRARYERELRELHE------------DKKRQ-----EEELRGQI 438
+ L HE +V +R ++ + + EL E DK +Q +L G++
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
Query: 439 REEKARTRELE----TLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLE 494
R +E+E L+ V+ELQ++ + A+ ++ + + E++ V L
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL---QNEVESVTGMLN 1297
Query: 495 QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 554
+A+ + K ++SL +++DT Q +L+++ L + LE +R + LQ++L
Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDT---QELLQEETRQKLNVSTKLRQLEEER-NSLQDQLD 1353
Query: 555 D 555
+
Sbjct: 1354 E 1354
Score = 40.0 bits (92), Expect = 0.006
Identities = 33/149 (22%), Positives = 70/149 (46%), Gaps = 3/149 (2%)
Query: 429 RQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQD 488
RQEEE++ + E + + + ++EL+ + + K + +L+ E ++
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 489 VRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADK 548
+R +L ++E + L + + +E +D + KK + + DL+ QL E K
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 549 LQERLQDILTNSKSRSGLEE-LVLSEMNS 576
LQ L+ + +K + +E LV+ + N+
Sbjct: 969 LQ--LEKVTAEAKIKKLEDEILVMDDQNN 995
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 105 bits (263), Expect = 1e-22
Identities = 153/707 (21%), Positives = 293/707 (41%), Gaps = 123/707 (17%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLD-KEFSKAQKALSKSKKA 65
E + Q +Q++ + +L+D++ K E+ S+ + + K A+ S S +
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 66 QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE--AGKFSAVSEGQGDPP 123
Q+ + LL E + + ++ + ++L + +E K+ S ++ D
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 124 GGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEEL-------- 175
L E + +++ E E +E+ + +RLQ+EL
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 176 --AKLSEKLKKKQESFCRLQTEKETL---FNDSRNKIEELQQRKEA-------------D 217
+L L+KKQ F +L E++ + + D R++ E + KE +
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 218 HKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEG 277
K +L RT K+ L+A + L +D E + RAL+ Q+ +E +
Sbjct: 1505 AKEELERTNKM---LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 278 LLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYED----------- 326
L A +A ++ ++ ++L EQ +LQ+Q EYE
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 327 -------LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEK---- 375
L G DL Q +++ ++QL+++ + + +EL++AR S ++
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 376 -----RKAMLDELAMETLQE---------------KSQHKEEL-----GAVRLRHEKEVL 410
+KA E + LQE K + EEL G L+ EK L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 411 GVR-ARYERELRELHEDKK----------RQEEELRGQIREEKARTRELETLQQTVE--- 456
R A+ E EL E + + +Q E+L ++ E++ ++ E+ +Q +E
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 457 -ELQAQVHSMDGA-KGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEV 514
EL++++H M+GA K F+ + E K +L++ Q+EQ E+ K++ +++
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE---QVEQEAREKQAATKSLKQKDKKL 1858
Query: 515 KDTV----DGQRILEK------KGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRS 564
K+ + D +++ E+ KG+A +K LKRQL ++ +E Q I N +
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-------EEAEEESQRINANRRKL- 1910
Query: 565 GLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARVRG 611
+ L E + + +++ S ++ R E+S VP+R G
Sbjct: 1911 ---QRELDEATESNEAMGREVNALKS----KLRRGNETSFVPSRRSG 1950
Score = 95.9 bits (237), Expect = 1e-19
Identities = 130/606 (21%), Positives = 255/606 (42%), Gaps = 85/606 (14%)
Query: 8 EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
E+ +QAQ+ EL+ + +EL+ +A LD E ++ AL KK +E
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQA----------ALARLDDEIAQKNNAL---KKIRE 1122
Query: 68 VEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGPA 127
+E +S+ LQ L S+ + AE K G+E E D
Sbjct: 1123 LEGHISD---LQEDLDSERA------ARNKAEKQKRDLGEELEALKTELEDTLDSTA--- 1170
Query: 128 PTVLAPMPLAEVELKWEMEKEE---KRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKK 184
+ EL+ + E+E K+ L E+ + E+ Q + + + +L+E+L++
Sbjct: 1171 ---------TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 185 KQESFCRLQTEKETLFNDSRNKIEEL----QQRKEADHKAQL--ARTQKLQQELEAANQS 238
+ + L K+TL ++ + EL Q ++E +HK + A+ Q+LQ + ++
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281
Query: 239 LAELRD-----QRQGERLE------HAAALRALQDQVSIQSA--DAQEQVEGLLAENNAL 285
AEL D Q + E + A++ +D S+ S D QE ++ + +
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 345
T L LE+ + + +L+ E L + + D + D S ++
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1401
Query: 346 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME---------TLQEKSQHKE 396
R ++++ + Q+ E+ + K+ + + LD+L ++ L++K + +
Sbjct: 1402 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 397 ELGAVRLRHEKEVLGVRARYERELRELH----------EDKKRQEEELRGQIREEKARTR 446
+L A + R R E E RE E+ +EEL R K
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE---RTNKMLKA 1518
Query: 447 ELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKT 506
E+E L + +++ VH ++ +K E +++E + + EEL+D E A+ + +++
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ- 1577
Query: 507 ISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLH-LERKRADKLQERLQDILTNSKSRSG 565
+LK + + + + +++ + L+RQLH E + D+ ++R K
Sbjct: 1578 --ALKGQFERDLQAR---DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 566 LEELVL 571
L++L L
Sbjct: 1633 LKDLEL 1638
Score = 90.1 bits (222), Expect = 5e-18
Identities = 132/601 (21%), Positives = 255/601 (42%), Gaps = 97/601 (16%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYL------DKEFSKAQKA 58
L+ + F + Q QL ++ + L+ + L KV L ++E +
Sbjct: 808 LARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDE 867
Query: 59 LSKSKKAQEVEVLLSENEMLQAKL-HSQ-EEDFRLQNSTLMAEFSKERYGKEAGKFSAVS 116
L K+K+ Q+ +ENE+ + + HSQ E+ L L AE E Y +
Sbjct: 868 LQKTKERQQK----AENELKELEQKHSQLTEEKNLLQEQLQAE--TELYAE--------- 912
Query: 117 EGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELA 176
A + + + EL+ + + E RL E+ +G + QAE ++ +++
Sbjct: 913 ----------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL--QAERKKMAQQML 960
Query: 177 KLSEKLKKKQESFCRLQTEKET-------------LFNDSRNKIEELQQRKEADHKAQLA 223
L E+L++++ + +LQ EK T + +D NK+ + +RK + +
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK--ERKLLEERISDL 1018
Query: 224 RTQKLQQELEAAN--------QSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQV 275
T ++E +A N +S+ + R + + L L+ ++ ++D EQ+
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 276 EGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLN 335
L A+ L+ LA K +EL + A+ + +L G DL
Sbjct: 1079 ADLQAQIAELKMQLA-------KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 336 SQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHK 395
L A ++ +Q +++G+E E L EL++ S A EL + QE + K
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST----ATQQELRAKREQEVTVLK 1187
Query: 396 EELGAVRLRHEKEVLGVRARYERELRELHE------------DKKRQ-----EEELRGQI 438
+ L HE +V +R ++ + + EL E DK +Q +L G++
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
Query: 439 REEKARTRELE----TLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLE 494
R +E+E L+ V+ELQ++ + A+ ++ + + E++ V L
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL---QNEVESVTGMLN 1304
Query: 495 QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 554
+A+ + K ++SL +++DT Q +L+++ L + LE +R + LQ++L
Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDT---QELLQEETRQKLNVSTKLRQLEEER-NSLQDQLD 1360
Query: 555 D 555
+
Sbjct: 1361 E 1361
Score = 40.0 bits (92), Expect = 0.006
Identities = 33/149 (22%), Positives = 70/149 (46%), Gaps = 3/149 (2%)
Query: 429 RQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQD 488
RQEEE++ + E + + + ++EL+ + + K + +L+ E ++
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 489 VRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADK 548
+R +L ++E + L + + +E +D + KK + + DL+ QL E K
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 549 LQERLQDILTNSKSRSGLEE-LVLSEMNS 576
LQ L+ + +K + +E LV+ + N+
Sbjct: 976 LQ--LEKVTAEAKIKKLEDEILVMDDQNN 1002
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 105 bits (263), Expect = 1e-22
Identities = 149/685 (21%), Positives = 283/685 (41%), Gaps = 115/685 (16%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLD-KEFSKAQKALSKSKKA 65
E + Q +Q++ + +L+D++ K E+ S+ + + K A+ S S +
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 66 QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE--AGKFSAVSEGQGDPP 123
Q+ + LL E + + ++ + ++L + +E K+ S ++ D
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1384
Query: 124 GGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEEL-------- 175
L E + +++ E E +E+ + +RLQ+EL
Sbjct: 1385 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1444
Query: 176 --AKLSEKLKKKQESFCRLQTEKETL---FNDSRNKIEELQQRKEA-------------D 217
+L L+KKQ F +L E++ + + D R++ E + KE +
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 218 HKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEG 277
K +L RT K+ L+A + L +D E + RAL+ Q+ +E +
Sbjct: 1505 AKEELERTNKM---LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 278 LLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYED----------- 326
L A +A ++ ++ ++L EQ +LQ+Q EYE
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 327 -------LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEK---- 375
L G DL Q +++ ++QL+++ + + +EL++AR S ++
Sbjct: 1622 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1681
Query: 376 -----RKAMLDELAMETLQE---------------KSQHKEEL-----GAVRLRHEKEVL 410
+KA E + LQE K + EEL G L+ EK L
Sbjct: 1682 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1741
Query: 411 GVR-ARYERELRELHEDKK----------RQEEELRGQIREEKARTRELETLQQTVE--- 456
R A+ E EL E + + +Q E+L ++ E++ ++ E+ +Q +E
Sbjct: 1742 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1801
Query: 457 -ELQAQVHSMDGA-KGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEV 514
EL++++H M+GA K F+ + E K +L++ Q+EQ E+ K++ +++
Sbjct: 1802 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE---QVEQEAREKQAATKSLKQKDKKL 1858
Query: 515 KDTV----DGQRILEK------KGSAALKDLKRQLHLERKRADKLQ------ERLQDILT 558
K+ + D +++ E+ KG+A +K LKRQL + + ++ +R D T
Sbjct: 1859 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918
Query: 559 NSKSRSGLEELVL-SEMNSPSRTQT 582
S G E L S++ P +T
Sbjct: 1919 ESNEAMGREVNALKSKLRGPPPQET 1943
Score = 95.9 bits (237), Expect = 1e-19
Identities = 130/606 (21%), Positives = 255/606 (42%), Gaps = 85/606 (14%)
Query: 8 EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
E+ +QAQ+ EL+ + +EL+ +A LD E ++ AL KK +E
Sbjct: 1076 EQIADLQAQIAELKMQLAKKEEELQA----------ALARLDDEIAQKNNAL---KKIRE 1122
Query: 68 VEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGPA 127
+E +S+ LQ L S+ + AE K G+E E D
Sbjct: 1123 LEGHISD---LQEDLDSERA------ARNKAEKQKRDLGEELEALKTELEDTLDSTA--- 1170
Query: 128 PTVLAPMPLAEVELKWEMEKEE---KRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKK 184
+ EL+ + E+E K+ L E+ + E+ Q + + + +L+E+L++
Sbjct: 1171 ---------TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1221
Query: 185 KQESFCRLQTEKETLFNDSRNKIEEL----QQRKEADHKAQL--ARTQKLQQELEAANQS 238
+ + L K+TL ++ + EL Q ++E +HK + A+ Q+LQ + ++
Sbjct: 1222 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1281
Query: 239 LAELRD-----QRQGERLE------HAAALRALQDQVSIQSA--DAQEQVEGLLAENNAL 285
AEL D Q + E + A++ +D S+ S D QE ++ + +
Sbjct: 1282 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1341
Query: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 345
T L LE+ + + +L+ E L + + D + D S ++
Sbjct: 1342 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1401
Query: 346 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME---------TLQEKSQHKE 396
R ++++ + Q+ E+ + K+ + + LD+L ++ L++K + +
Sbjct: 1402 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1461
Query: 397 ELGAVRLRHEKEVLGVRARYERELRELH----------EDKKRQEEELRGQIREEKARTR 446
+L A + R R E E RE E+ +EEL R K
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE---RTNKMLKA 1518
Query: 447 ELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKT 506
E+E L + +++ VH ++ +K E +++E + + EEL+D E A+ + +++
Sbjct: 1519 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ- 1577
Query: 507 ISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLH-LERKRADKLQERLQDILTNSKSRSG 565
+LK + + + + +++ + L+RQLH E + D+ ++R K
Sbjct: 1578 --ALKGQFERDLQAR---DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 566 LEELVL 571
L++L L
Sbjct: 1633 LKDLEL 1638
Score = 90.1 bits (222), Expect = 5e-18
Identities = 132/601 (21%), Positives = 255/601 (42%), Gaps = 97/601 (16%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYL------DKEFSKAQKA 58
L+ + F + Q QL ++ + L+ + L KV L ++E +
Sbjct: 808 LARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDE 867
Query: 59 LSKSKKAQEVEVLLSENEMLQAKL-HSQ-EEDFRLQNSTLMAEFSKERYGKEAGKFSAVS 116
L K+K+ Q+ +ENE+ + + HSQ E+ L L AE E Y +
Sbjct: 868 LQKTKERQQK----AENELKELEQKHSQLTEEKNLLQEQLQAE--TELYAE--------- 912
Query: 117 EGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELA 176
A + + + EL+ + + E RL E+ +G + QAE ++ +++
Sbjct: 913 ----------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL--QAERKKMAQQML 960
Query: 177 KLSEKLKKKQESFCRLQTEKET-------------LFNDSRNKIEELQQRKEADHKAQLA 223
L E+L++++ + +LQ EK T + +D NK+ + +RK + +
Sbjct: 961 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK--ERKLLEERISDL 1018
Query: 224 RTQKLQQELEAAN--------QSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQV 275
T ++E +A N +S+ + R + + L L+ ++ ++D EQ+
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 276 EGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLN 335
L A+ L+ LA K +EL + A+ + +L G DL
Sbjct: 1079 ADLQAQIAELKMQLA-------KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 336 SQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHK 395
L A ++ +Q +++G+E E L EL++ S A EL + QE + K
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST----ATQQELRAKREQEVTVLK 1187
Query: 396 EELGAVRLRHEKEVLGVRARYERELRELHE------------DKKRQ-----EEELRGQI 438
+ L HE +V +R ++ + + EL E DK +Q +L G++
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1247
Query: 439 REEKARTRELE----TLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLE 494
R +E+E L+ V+ELQ++ + A+ ++ + + E++ V L
Sbjct: 1248 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL---QNEVESVTGMLN 1304
Query: 495 QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 554
+A+ + K ++SL +++DT Q +L+++ L + LE +R + LQ++L
Sbjct: 1305 EAEGKAIKLAKDVASLSSQLQDT---QELLQEETRQKLNVSTKLRQLEEER-NSLQDQLD 1360
Query: 555 D 555
+
Sbjct: 1361 E 1361
Score = 40.0 bits (92), Expect = 0.006
Identities = 33/149 (22%), Positives = 70/149 (46%), Gaps = 3/149 (2%)
Query: 429 RQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQD 488
RQEEE++ + E + + + ++EL+ + + K + +L+ E ++
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 489 VRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADK 548
+R +L ++E + L + + +E +D + KK + + DL+ QL E K
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 549 LQERLQDILTNSKSRSGLEE-LVLSEMNS 576
LQ L+ + +K + +E LV+ + N+
Sbjct: 976 LQ--LEKVTAEAKIKKLEDEILVMDDQNN 1002
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 105 bits (263), Expect = 1e-22
Identities = 149/685 (21%), Positives = 283/685 (41%), Gaps = 115/685 (16%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLD-KEFSKAQKALSKSKKA 65
E + Q +Q++ + +L+D++ K E+ S+ + + K A+ S S +
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 66 QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE--AGKFSAVSEGQGDPP 123
Q+ + LL E + + ++ + ++L + +E K+ S ++ D
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSK 1377
Query: 124 GGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEEL-------- 175
L E + +++ E E +E+ + +RLQ+EL
Sbjct: 1378 KKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLD 1437
Query: 176 --AKLSEKLKKKQESFCRLQTEKETL---FNDSRNKIEELQQRKEA-------------D 217
+L L+KKQ F +L E++ + + D R++ E + KE +
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 218 HKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEG 277
K +L RT K+ L+A + L +D E + RAL+ Q+ +E +
Sbjct: 1498 AKEELERTNKM---LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 278 LLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYED----------- 326
L A +A ++ ++ ++L EQ +LQ+Q EYE
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 327 -------LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEK---- 375
L G DL Q +++ ++QL+++ + + +EL++AR S ++
Sbjct: 1615 AAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFAT 1674
Query: 376 -----RKAMLDELAMETLQE---------------KSQHKEEL-----GAVRLRHEKEVL 410
+KA E + LQE K + EEL G L+ EK L
Sbjct: 1675 AKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRL 1734
Query: 411 GVR-ARYERELRELHEDKK----------RQEEELRGQIREEKARTRELETLQQTVE--- 456
R A+ E EL E + + +Q E+L ++ E++ ++ E+ +Q +E
Sbjct: 1735 EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN 1794
Query: 457 -ELQAQVHSMDGA-KGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEV 514
EL++++H M+GA K F+ + E K +L++ Q+EQ E+ K++ +++
Sbjct: 1795 KELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEE---QVEQEAREKQAATKSLKQKDKKL 1851
Query: 515 KDTV----DGQRILEK------KGSAALKDLKRQLHLERKRADKLQ------ERLQDILT 558
K+ + D +++ E+ KG+A +K LKRQL + + ++ +R D T
Sbjct: 1852 KEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911
Query: 559 NSKSRSGLEELVL-SEMNSPSRTQT 582
S G E L S++ P +T
Sbjct: 1912 ESNEAMGREVNALKSKLRGPPPQET 1936
Score = 95.9 bits (237), Expect = 1e-19
Identities = 130/606 (21%), Positives = 255/606 (42%), Gaps = 85/606 (14%)
Query: 8 EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
E+ +QAQ+ EL+ + +EL+ +A LD E ++ AL KK +E
Sbjct: 1069 EQIADLQAQIAELKMQLAKKEEELQA----------ALARLDDEIAQKNNAL---KKIRE 1115
Query: 68 VEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGPA 127
+E +S+ LQ L S+ + AE K G+E E D
Sbjct: 1116 LEGHISD---LQEDLDSERA------ARNKAEKQKRDLGEELEALKTELEDTLDSTA--- 1163
Query: 128 PTVLAPMPLAEVELKWEMEKEE---KRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKK 184
+ EL+ + E+E K+ L E+ + E+ Q + + + +L+E+L++
Sbjct: 1164 ---------TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQ 1214
Query: 185 KQESFCRLQTEKETLFNDSRNKIEEL----QQRKEADHKAQL--ARTQKLQQELEAANQS 238
+ + L K+TL ++ + EL Q ++E +HK + A+ Q+LQ + ++
Sbjct: 1215 FKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERA 1274
Query: 239 LAELRD-----QRQGERLE------HAAALRALQDQVSIQSA--DAQEQVEGLLAENNAL 285
AEL D Q + E + A++ +D S+ S D QE ++ + +
Sbjct: 1275 RAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV 1334
Query: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 345
T L LE+ + + +L+ E L + + D + D S ++
Sbjct: 1335 STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1394
Query: 346 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME---------TLQEKSQHKE 396
R ++++ + Q+ E+ + K+ + + LD+L ++ L++K + +
Sbjct: 1395 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD 1454
Query: 397 ELGAVRLRHEKEVLGVRARYERELRELH----------EDKKRQEEELRGQIREEKARTR 446
+L A + R R E E RE E+ +EEL R K
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE---RTNKMLKA 1511
Query: 447 ELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKT 506
E+E L + +++ VH ++ +K E +++E + + EEL+D E A+ + +++
Sbjct: 1512 EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ- 1570
Query: 507 ISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLH-LERKRADKLQERLQDILTNSKSRSG 565
+LK + + + + +++ + L+RQLH E + D+ ++R K
Sbjct: 1571 --ALKGQFERDLQAR---DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 566 LEELVL 571
L++L L
Sbjct: 1626 LKDLEL 1631
Score = 90.1 bits (222), Expect = 5e-18
Identities = 132/601 (21%), Positives = 255/601 (42%), Gaps = 97/601 (16%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYL------DKEFSKAQKA 58
L+ + F + Q QL ++ + L+ + L KV L ++E +
Sbjct: 801 LARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDE 860
Query: 59 LSKSKKAQEVEVLLSENEMLQAKL-HSQ-EEDFRLQNSTLMAEFSKERYGKEAGKFSAVS 116
L K+K+ Q+ +ENE+ + + HSQ E+ L L AE E Y +
Sbjct: 861 LQKTKERQQK----AENELKELEQKHSQLTEEKNLLQEQLQAE--TELYAE--------- 905
Query: 117 EGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELA 176
A + + + EL+ + + E RL E+ +G + QAE ++ +++
Sbjct: 906 ----------AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL--QAERKKMAQQML 953
Query: 177 KLSEKLKKKQESFCRLQTEKET-------------LFNDSRNKIEELQQRKEADHKAQLA 223
L E+L++++ + +LQ EK T + +D NK+ + +RK + +
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSK--ERKLLEERISDL 1011
Query: 224 RTQKLQQELEAAN--------QSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQV 275
T ++E +A N +S+ + R + + L L+ ++ ++D EQ+
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 276 EGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLN 335
L A+ L+ LA K +EL + A+ + +L G DL
Sbjct: 1072 ADLQAQIAELKMQLA-------KKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124
Query: 336 SQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHK 395
L A ++ +Q +++G+E E L EL++ S A EL + QE + K
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDST----ATQQELRAKREQEVTVLK 1180
Query: 396 EELGAVRLRHEKEVLGVRARYERELRELHE------------DKKRQ-----EEELRGQI 438
+ L HE +V +R ++ + + EL E DK +Q +L G++
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGEL 1240
Query: 439 REEKARTRELE----TLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLE 494
R +E+E L+ V+ELQ++ + A+ ++ + + E++ V L
Sbjct: 1241 RVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL---QNEVESVTGMLN 1297
Query: 495 QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQ 554
+A+ + K ++SL +++DT Q +L+++ L + LE +R + LQ++L
Sbjct: 1298 EAEGKAIKLAKDVASLSSQLQDT---QELLQEETRQKLNVSTKLRQLEEER-NSLQDQLD 1353
Query: 555 D 555
+
Sbjct: 1354 E 1354
Score = 40.0 bits (92), Expect = 0.006
Identities = 33/149 (22%), Positives = 70/149 (46%), Gaps = 3/149 (2%)
Query: 429 RQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQD 488
RQEEE++ + E + + + ++EL+ + + K + +L+ E ++
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 489 VRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADK 548
+R +L ++E + L + + +E +D + KK + + DL+ QL E K
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 549 LQERLQDILTNSKSRSGLEE-LVLSEMNS 576
LQ L+ + +K + +E LV+ + N+
Sbjct: 969 LQ--LEKVTAEAKIKKLEDEILVMDDQNN 995
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 105 bits (261), Expect = 2e-22
Identities = 164/656 (25%), Positives = 272/656 (41%), Gaps = 114/656 (17%)
Query: 9 EFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKA-------QKALSK 61
E +M ++ +L N LS +LR+ L L+ + L +E SKA Q L K
Sbjct: 305 EKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEK 364
Query: 62 SKKA--QEVEVLLSENEMLQAKLHSQEEDF-RLQNST------LMAEFSKERYGKEAGKF 112
A Q+ + L +NE+LQ KL EE +LQ++ ++ + + K+
Sbjct: 365 ELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAAT 424
Query: 113 SAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRL-------------LWEQLQG 159
A + Q T + + E+E+++L L + +
Sbjct: 425 LAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEE 484
Query: 160 LESSKQAETSRL---------------------QEELAKLSEKLKKKQESFCRLQTEKET 198
LE + QA +RL +ELA L ++ K+KQ + ++E
Sbjct: 485 LEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQ 544
Query: 199 LFNDSRNKIEEL--------QQRKEADHKAQLARTQKLQQELEAANQSLAELRDQ----R 246
R+++E+L QQ KE K + R QQ AA + A LR++ +
Sbjct: 545 ASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALK 604
Query: 247 QGERL--EHAAALRALQDQVSIQSA---DAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
Q E L E AA L LQ Q+ + + AQ V E L + L+ Q
Sbjct: 605 QLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQ 664
Query: 302 ELNMLREQTTGLAAEL--QQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEK 359
E + + Q L +L +QQ+A ++ + Q+ D QLQE L+A L E L+ K
Sbjct: 665 EQHEAQAQVAELELQLRSEQQKATEKERVAQEKD---QLQEQLQA---LKESLK---VTK 715
Query: 360 EQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE 419
L +E + A + E+++ + EL ET QHK E R E+E G R E
Sbjct: 716 GSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRE----RKELEEERAG-RKGLEAR 770
Query: 420 LRELHEDKKRQEEELRGQIREEKARTRELET-LQQTVEELQAQVHSMDGAK-------GW 471
L++L E + + E LR ++ E A E+ +Q V+E+ A + ++
Sbjct: 771 LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAM 830
Query: 472 FERRL----KEAEGKEEELQDVRDQL------------EQAQEERDCHLKTISSLKQEVK 515
F+ +L +E E +ELQ+ ++++ Q E + H +L+Q +
Sbjct: 831 FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQE 890
Query: 516 DTVDGQRI------LEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSG 565
V Q++ L++K +A K++ R L RK A + QE L +R+G
Sbjct: 891 KEVRAQKLADDLSTLQEKMAATSKEVARLETLVRK-AGEQQETASRELVKEPARAG 945
Score = 102 bits (255), Expect = 8e-22
Identities = 146/641 (22%), Positives = 273/641 (42%), Gaps = 70/641 (10%)
Query: 1 MAQALSEEEFQ--RMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKA--- 55
M L +FQ R++ QL + R+N +L EL +N LT ++A + + +
Sbjct: 205 MGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALL 264
Query: 56 -QKALSKSKKAQEVEVLLSENEMLQAKLH---SQEEDFRLQNSTLMAEFSKERYGKEAGK 111
+K + + +E+E L +NE L +LH Q +D + + S + K
Sbjct: 265 NEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQM------------DRK 312
Query: 112 FSAVSEGQGDPPG--GPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA--- 166
+ +SE GD + L + A EL E K + L +Q Q LE A
Sbjct: 313 INQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQ-LEKELSAALQ 371
Query: 167 ETSRLQEELAKLSEKLKKKQESFCRLQ----TEKETLFNDSRNKIEELQQRKE--ADHKA 220
+ L+E+ L KL + +E +LQ EK + D ++E L+Q A +
Sbjct: 372 DKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVL-QLETLKQEAATLAANNT 430
Query: 221 QL-ARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 279
QL AR + L+ E L R + E+ + ++ + LQ +S S +E +
Sbjct: 431 QLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQ 490
Query: 280 AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ 339
A L +A+L T + ++ GL + +++QA+ + Q++ + L+
Sbjct: 491 AHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLR 550
Query: 340 ESLRANSRLL----EQLQEIGQEKEQLTQE-LQEARKSAEKRKAMLDELAMETLQEKSQH 394
+ S L +QL+E+ +++E Q+ Q+ +AE+R+A L E Q ++
Sbjct: 551 HQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALE 610
Query: 395 KEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQT 454
KE+ + E+L + + E R+ + Q + RE+ +R++E LQ
Sbjct: 611 KEKAAKL------EILQQQLQVANEARDSAQTSVTQAQ------REKAELSRKVEELQAC 658
Query: 455 VEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEV 514
VE + + H E +L+ + K E + V + +Q QE+ + +LK+ +
Sbjct: 659 VETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQ-------LQALKESL 711
Query: 515 KDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEM 574
K T +++ + AL++ +R + + L E+ + + R LEE
Sbjct: 712 KVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQ------HKRERKELEEERAGRK 765
Query: 575 NSPSR-TQTGDSSSISSFSYREILREKESSAVPARVRGKEE 614
+R Q G++ + E+LR + + A+ A+ + E
Sbjct: 766 GLEARLQQLGEAHQAET----EVLRRELAEAMAAQHTAESE 802
Score = 100 bits (248), Expect = 5e-21
Identities = 137/591 (23%), Positives = 252/591 (42%), Gaps = 71/591 (12%)
Query: 8 EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
+ + Q + EL+ L ++ ++ EL R L+ + +A E
Sbjct: 727 DALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEA-----HQAE 781
Query: 68 VEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYG---KEAGKFSAVSEGQGDPPG 124
EVL E A H+ E + + A +ERY +E ++ A+ + Q
Sbjct: 782 TEVLRRELAEAMAAQHTAESECEQLVKEVAAW--RERYEDSQQEEAQYGAMFQEQ----- 834
Query: 125 GPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKK 184
L ++ + E ++E + E++ G+ES + + SR Q ELA+L L +
Sbjct: 835 -----------LMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLAR 883
Query: 185 KQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQ----KLQQELEAANQSLA 240
+ + + L +D + LQ++ A K ++AR + K ++ E A++ L
Sbjct: 884 ALQQVQEKEVRAQKLADD----LSTLQEKMAATSK-EVARLETLVRKAGEQQETASRELV 938
Query: 241 E---LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQT 297
+ RQ E LE + Q ++Q+ + + + G N L AAL + Q
Sbjct: 939 KEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMG-----NELERLRAALMESQG 993
Query: 298 AKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN----SRLLEQLQ 353
+ +E + L E + QA+ + +L +LQ +L + L E L
Sbjct: 994 QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 1053
Query: 354 EIGQEKEQLTQELQEAR-------KSAEKRKAMLDELAMETLQEKSQHKEELGAV-RLRH 405
EKE QEL + R K E+ + + +L + +++ +H GA
Sbjct: 1054 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113
Query: 406 EKEVLGVRARYER-ELRELHEDKKRQEEE---LRGQIREEKARTRE----LETLQQTVEE 457
E G + R E+ +L + ++Q+E+ L + E+A E LETLQ +EE
Sbjct: 1114 RTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEE 1173
Query: 458 LQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRD----QLEQAQEERDCHLKTISSLKQE 513
++ A +R L K ++ D Q+ + ++E + ISSL++E
Sbjct: 1174 KAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEE 1233
Query: 514 VKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRS 564
V ++ +++LEK+G + K+LKR + E +++ KL+ERL+ + + S S
Sbjct: 1234 V--SILNRQVLEKEGES--KELKRLVMAESEKSQKLEERLRLLQAETASNS 1280
Score = 85.1 bits (209), Expect = 2e-16
Identities = 137/541 (25%), Positives = 229/541 (42%), Gaps = 62/541 (11%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGV-------ELTSLRQKVAYLDKEFSKAQKA 58
SE + R Q +L EL N + ++++ V +L++L++K+A KE ++ +
Sbjct: 863 SELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETL 922
Query: 59 LSKSKKAQEV-------EVLLSENEMLQAKLHSQEEDFRLQNSTLMA-EFSKERYGKEAG 110
+ K+ + QE E + + + Q F + L A E E+ G E
Sbjct: 923 VRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELE 982
Query: 111 KFSAV---SEGQGDPPGGPAPTVLAPMPL--AEVELKWEMEKEEKRLLWEQLQGLESSKQ 165
+ A S+GQ G +A + + +EK + L +LQ + ++
Sbjct: 983 RLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQR 1042
Query: 166 AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 225
E + LQE LA + + K + +L+ + + +EEL+Q + K QLA+
Sbjct: 1043 VEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKE----LEELRQTVK-QLKEQLAKK 1097
Query: 226 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 285
+K + + QS A R + G +LE ALRA ++ Q QEQ + L A
Sbjct: 1098 EK-EHASGSGAQSEAAGRTEPTGPKLE---ALRAEVSKLEQQCQKQQEQADSLERSLEAE 1153
Query: 286 RTSLA----ALEQIQ---TAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQL 338
R S A ALE +Q K QEL + EL + + +D +D+ +Q+
Sbjct: 1154 RASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQV 1213
Query: 339 ----QESLRANSRL--LEQ---------LQEIGQEKEQLTQELQEARKSAEKRKAMLDEL 383
QE+ R NS + LE+ L++ G+ KE + E+ KS +K + L L
Sbjct: 1214 ARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKS-QKLEERLRLL 1272
Query: 384 AMETLQEKSQHKEELGAVR-----LRHEKEVLGVRARYERELRELHEDKKRQEE---ELR 435
ET ++ E A+R LR E E V + R+ EL +R EE EL+
Sbjct: 1273 QAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQ--ELTSQAERAEELGQELK 1330
Query: 436 GQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQ 495
+ + + L TLQ QA V + AK ++ E E+ ++ +Q +Q
Sbjct: 1331 AWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQ 1390
Query: 496 A 496
A
Sbjct: 1391 A 1391
Score = 84.0 bits (206), Expect = 4e-16
Identities = 153/635 (24%), Positives = 259/635 (40%), Gaps = 95/635 (14%)
Query: 1 MAQALSEE--EFQRMQAQLLELRTNNYQLSDELRK-NGVE------LTSLRQKVAYLDKE 51
+ AL+E+ EF +Q L T EL K G+E L LRQ V L ++
Sbjct: 1034 LQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQ 1093
Query: 52 FSKAQKALSKSKKAQ------------EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAE 99
+K +K + AQ ++E L +E L+ + Q+E Q +L
Sbjct: 1094 LAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQE----QADSLERS 1149
Query: 100 FSKERYGKEAGKFSAVSEGQGDPPG-----GPAPTVLAPMPL------------AEVELK 142
ER + A + SA+ QG G + + LA ++ E +
Sbjct: 1150 LEAERASR-AERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE 1208
Query: 143 WEMEKEEKRLLWEQLQGLESSKQAETSRLQ----------EELAKL----SEKLKKKQES 188
W+ + R E+ L SS + E S L +EL +L SEK +K +E
Sbjct: 1209 WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEER 1268
Query: 189 FCRLQTEKETLFNDSRNKI------EELQQRKEADHKAQLARTQKLQQELEAANQSLAEL 242
LQ E T N +R EE+Q +E K ++A ++ L+QEL + + EL
Sbjct: 1269 LRLLQAE--TASNSARAAERSSALREEVQSLREEAEKQRVA-SENLRQELTSQAERAEEL 1325
Query: 243 RDQR---QGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAK 299
+ Q + + AL LQ ++ Q V LL + + A +
Sbjct: 1326 GQELKAWQEKFFQKEQALSTLQ----LEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRH 1381
Query: 300 TQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEK 359
+EL ++ GL AEL + Q E +L+ + + Q + + + + +++ K
Sbjct: 1382 REELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLK 1441
Query: 360 EQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE 419
+ +E R E+ L +E Q + ++ +EL AVR E + V+ +
Sbjct: 1442 KAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQST 1501
Query: 420 LREL------HEDKKRQEEELRGQIREEK----ARTRELETLQ----QTVEELQAQVHSM 465
REL +E K + E R + +EE+ A+ +LE Q + VEEL ++
Sbjct: 1502 ARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADS 1561
Query: 466 DGAKGWFERRLK--EAEGKE--EELQDVRDQLEQAQEERDCHLKTISSLK---QEVKDTV 518
D A +++LK +A+G E +E Q ++ QL + Q + + K ++ K
Sbjct: 1562 DQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHY 1621
Query: 519 DGQRILEKKGSAALKDLKRQLHLERKRADKLQERL 553
D ++ ++ L+ L+ QL E K ERL
Sbjct: 1622 DAKKQQNQELQEQLRSLE-QLQKENKELRAEAERL 1655
Score = 75.9 bits (185), Expect = 1e-13
Identities = 124/575 (21%), Positives = 230/575 (40%), Gaps = 74/575 (12%)
Query: 2 AQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK 61
++A + + +Q QL E L EL + R KV K + + +++
Sbjct: 1156 SRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVAR 1215
Query: 62 SKKAQE-----VEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVS 116
++ E + L E +L ++ +E + + +MAE K + +E +
Sbjct: 1216 GRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLL--- 1272
Query: 117 EGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELA 176
Q + A L E E E++R+ E L+ +S+ L +EL
Sbjct: 1273 --QAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELK 1330
Query: 177 KLSEKLKKKQESFCRLQ---TEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELE 233
EK +K+++ LQ T + L ++ QQ + A+ ++L+Q +
Sbjct: 1331 AWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQ 1390
Query: 234 AANQSLAEL-RDQRQ-GERL---EHAAALRALQDQVSIQSADAQEQVE------GLLAEN 282
AA AEL R QR+ GE + + A Q+ + A EQ+ GLLAE
Sbjct: 1391 AAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE 1450
Query: 283 N---ALRTSLAA------LEQIQTAKTQELNMLR-----------EQTTGLAAELQQQQA 322
N R +L L+Q + QEL +R + A EL+ A
Sbjct: 1451 NRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTA 1510
Query: 323 EYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ-------EARKSAEK 375
+YE + + + QE + + +EQL+ +E+ + +EL +A K ++
Sbjct: 1511 KYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQ 1570
Query: 376 RKAMLDELAMETLQEKSQHKEELGAVRLR-HEKEVLGVRARYERELRELHED-KKRQEEE 433
+ + E+ QE + + +L ++ + +KE + + E + H D KK+Q +E
Sbjct: 1571 KLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQE 1630
Query: 434 LRGQIR-------EEKARTRELETL--------------QQTVEELQAQVHSMDGAKGWF 472
L+ Q+R E K E E L +QT L AQV S++
Sbjct: 1631 LQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHA 1690
Query: 473 ERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTI 507
+++L++ + ++ + QA+ + D + ++
Sbjct: 1691 DQQLRDLGKFQVATDALKSREPQAKPQLDLSIDSL 1725
Score = 67.4 bits (163), Expect = 4e-11
Identities = 109/513 (21%), Positives = 209/513 (40%), Gaps = 65/513 (12%)
Query: 139 VELKWEMEKEEKRLLWEQLQG-LESSKQAET--SRLQEELAKLSEKLKKKQESFCRLQTE 195
V LK+ ++ E+ L E L+ L+ + T S EEL+ S + K++ L+ +
Sbjct: 129 VILKFVLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRF---LELQ 185
Query: 196 KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 255
K + N + A + +T + Q + + LA+ R R LE A
Sbjct: 186 KVASSSSGNNFLSG----SPASPMGDILQTPQFQ--MRRLKKQLADERSNRDELELE-LA 238
Query: 256 ALRALQDQVSIQSADAQEQVEGLLAENNALRTS------LAALEQIQTAKTQELNMLREQ 309
R L + Q A Q++++ L N S L L + T L+ +Q
Sbjct: 239 ENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQ 298
Query: 310 TTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEA 369
L E Q + L + DL+ +L+E +L + L E+ +E + TQE E
Sbjct: 299 CQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLE- 357
Query: 370 RKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVL-GVRARYERELRELHEDKK 428
++A L++ LQ+K L + E+L G ++ E L +L ++
Sbjct: 358 ------KQAQLEKELSAALQDKK---------CLEEKNEILQGKLSQLEEHLSQLQDNPP 402
Query: 429 RQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEE--- 485
+++ E+ G + + + +E TL +LQA+V ++ +G E +L G EE
Sbjct: 403 QEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQ 462
Query: 486 ---------------LQDVRDQLEQAQEERDCHLKT-ISSLKQE---VKDTVDGQ----R 522
L +++LEQA + L ++SL E + T+ Q
Sbjct: 463 QLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELA 522
Query: 523 ILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSR-SGLEELVLSEMNSPSRTQ 581
L+++ L + L + + + L+ +++ + ++ K + L+E ++E +R
Sbjct: 523 GLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE--VAEKQEATRQD 580
Query: 582 TGDSSSISSFSYREILREKESSAVPARVRGKEE 614
+ ++ LRE++++ KE+
Sbjct: 581 HAQQLATAAEEREASLRERDAALKQLEALEKEK 613
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 104 bits (260), Expect = 2e-22
Identities = 157/687 (22%), Positives = 296/687 (43%), Gaps = 98/687 (14%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQ 66
EE ++ + EL +L E ++ L+ ++ L + +K ++ L +
Sbjct: 1040 EERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARG 1099
Query: 67 EVEVLLSENEM-----LQAKLHSQEEDFRLQNSTL-MAEFSKERYGKEAGKFSAVSEGQG 120
+ E L N + LQA++ +EDF + ++ AE K +E E
Sbjct: 1100 DDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTL 1159
Query: 121 DPPGGPAPTVLAPMPLAEVELKWEMEKEE---KRLLWEQLQGLESSKQAETSRLQEELAK 177
D A+ EL+ + E+E K+ L E+ + E+ Q R L +
Sbjct: 1160 DTTA------------AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEE 1207
Query: 178 LSEKLKKKQESFCRLQTEKETLFNDSRN---KIEELQQRK-EADHKAQL--ARTQKLQQE 231
LSE+L++ + L+ K+ L D++ +++ LQQ K E++HK + A+ Q+L +
Sbjct: 1208 LSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAK 1267
Query: 232 LEAANQ---SLAELRDQRQGER------LEHAA--ALRALQDQVSIQSA--DAQEQVE-- 276
+ ++ LAE + Q E LE A ++ +D S++S D QE ++
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEE 1327
Query: 277 -----GLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQK 331
L + L +L++ Q + + L +Q L ++L + + +D +G
Sbjct: 1328 TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTI 1387
Query: 332 DDLNSQLQESLRANSRLLEQLQE--------------IGQEKEQLTQELQEARKSA---E 374
+ L ++ L+ L ++L+E + QE + LT +L R+ A E
Sbjct: 1388 ESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE 1447
Query: 375 KRKAMLDELAMETLQEKSQHKEELGAVRLR-HEKEVLGVR-ARYERELRELHEDKKRQEE 432
K++ D+L E +++ EE EKE + AR E E E+ +RQ +
Sbjct: 1448 KKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNK 1507
Query: 433 ELRGQIRE------------------EKARTRELETLQQTVEELQAQVHSMDGAKGWFER 474
+LR + + ++A +++E ++ +EEL+ ++ + + AK E
Sbjct: 1508 QLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEV 1567
Query: 475 RLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRIL----EKKGSA 530
++ + + E RD EQ +E++ +K + L+ E++D QR L +KK
Sbjct: 1568 NMQAMKAQFERDLQTRD--EQNEEKKRLLIKQVRELEAELEDERK-QRALAVASKKKMEI 1624
Query: 531 ALKDLKRQLHLERKRADKLQERLQDILTNSKS-RSGLEELVLS--EMNSPSRTQTGDSSS 587
LKDL+ Q+ K D++ ++L+ + K + LEE S E+ + S+ S
Sbjct: 1625 DLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKS 1684
Query: 588 ISSFSYREILREKESSAVPARVRGKEE 614
+ + EIL+ +E A R R E
Sbjct: 1685 LEA----EILQLQEELASSERARRHAE 1707
Score = 97.1 bits (240), Expect = 4e-20
Identities = 126/545 (23%), Positives = 232/545 (42%), Gaps = 76/545 (13%)
Query: 136 LAEVELKWEMEKEEKRLLWEQLQG----------LESSKQAETSRLQEELAKLSEKLKKK 185
L E+E K + EEK +L EQLQ + + A+ L+E L L +++++
Sbjct: 875 LEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEE 934
Query: 186 QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQL------ARTQKLQQE---LEAAN 236
+E LQ EK+ + ++ E+L + + A K QL A+ +K+++E LE N
Sbjct: 935 EERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQN 994
Query: 237 QS-----------LAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 285
+AE Q E E A L ++++ + +D +E+++ L
Sbjct: 995 SKFIKEKKLMEDRIAECSSQ-LAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053
Query: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 345
+ L+ T ++ L+ Q L +L +++ E + + + DD +L+
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113
Query: 346 SRLLEQLQEIGQ--------------EKEQLTQELQEARKSAE---KRKAMLDELAMETL 388
L Q+ E+ + +K L++EL+ + E A EL +
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE 1173
Query: 389 QEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHED-------KKRQEEELRGQIREE 441
QE ++ K+ L HE ++ +R R+ L EL E K E+ +G +
Sbjct: 1174 QEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN 1233
Query: 442 KARTRELETLQQTVEE-------LQAQVHSMDGAKGWFERRLKEAEGK----EEELQDVR 490
K E++ LQQ E L AQV + +R E K + EL +V
Sbjct: 1234 KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVS 1293
Query: 491 DQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQ 550
LE+A+++ K +SL+ +++DT Q +L+++ L R LE ++ + LQ
Sbjct: 1294 TLLEEAEKKGIKFAKDAASLESQLQDT---QELLQEETRQKLNLSSRIRQLEEEK-NSLQ 1349
Query: 551 ERLQDILTNSKSRSGLEELVL---SEMNSPSRTQTGDSSSISSFSYREILREKESSAVPA 607
E+ ++ ++R LE+ VL S++ + D +I S + K++ A+
Sbjct: 1350 EQQEE---EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQ 1406
Query: 608 RVRGK 612
R+ K
Sbjct: 1407 RLEEK 1411
Score = 95.9 bits (237), Expect = 1e-19
Identities = 136/628 (21%), Positives = 281/628 (44%), Gaps = 77/628 (12%)
Query: 3 QALSEEEFQRMQAQLLELR---TNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK----- 54
+A SE + +++ AQ+ EL + +L EL + +L + V+ L +E K
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306
Query: 55 AQKALSKSKKAQEVEVLLSENEMLQAKLHS-----QEEDFRLQNSTLMAEFSKERYGKEA 109
A+ A S + Q+ + LL E + L S +EE LQ E +++ K+
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366
Query: 110 ----GKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQ 165
+ + + D G A L + EEK L +++L+ ++ Q
Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQ 1426
Query: 166 AETSRLQEEL---AKLSEKLKKKQESFCRLQTEKETL---FNDSRNKIEELQQRKEADHK 219
E L +L +++ L+KKQ+ F +L E++++ + + R++ E + KE
Sbjct: 1427 QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKAL 1486
Query: 220 A---QLARTQKLQQELEAANQSL-AELRDQRQ-----GERL-EHAAALRALQDQVSIQSA 269
+ L + ++E E N+ L A++ D G+ + E + RAL+ QV
Sbjct: 1487 SLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRT 1546
Query: 270 DAQEQVEGLLAENNA---LRTSLAALE-----QIQTAKTQ---ELNMLREQTTGLAAELQ 318
+E + L A +A L ++ A++ +QT Q + +L +Q L AEL+
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE 1606
Query: 319 QQQAEYEDLMGQKD-------DLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARK 371
++ + + K DL +Q++ + +A +++QL+++ + + +EL+EAR
Sbjct: 1607 DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 372 SAEK--RKAMLDELAMETLQ-EKSQHKEELGA---VRLRHEKE----------------- 408
S ++ ++ E +++L+ E Q +EEL + R E+E
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSA 1726
Query: 409 VLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGA 468
+L + R E + +L E+ + ++ + + T +++TL + ++ D A
Sbjct: 1727 LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNA 1786
Query: 469 KGWFERRLKEAEGKEEELQD-VRDQLEQAQEERDCHLKTISS-LKQEVKDTVDGQRILEK 526
+ ER+ KE + K +EL+ V+ + + + + + L+QE K+ +++ +
Sbjct: 1787 RQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLV-R 1845
Query: 527 KGSAALKDLKRQLHLERKRADKLQERLQ 554
+ LK++ Q+ ER+ AD+ +E+++
Sbjct: 1846 RTEKKLKEIFMQVEDERRHADQYKEQME 1873
Score = 94.4 bits (233), Expect = 3e-19
Identities = 127/585 (21%), Positives = 249/585 (42%), Gaps = 80/585 (13%)
Query: 2 AQALSEEEFQRMQAQLL---ELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKA 58
A+ALS QR++ + L +L +L EL V+L RQ + L+K+ K +
Sbjct: 1401 AEALS----QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQL 1456
Query: 59 LSKSK---------------KAQEVEV-LLSENEMLQAKLHSQEEDFRLQNSTLMAEF-- 100
L++ K +A+E E LS L+ L ++EE F QN L A+
Sbjct: 1457 LAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE-FERQNKQLRADMED 1515
Query: 101 ---SKERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQL 157
SK+ GK + + E+ + E ++E + +
Sbjct: 1516 LMSSKDDVGKNVHELEKSKRA-------------LEQQVEEMRTQLEELEDELQATEDAK 1562
Query: 158 QGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEAD 217
LE + QA ++ + +L E+ ++K+ + E E D R + + A
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ----RALAVAS 1618
Query: 218 HKAQLARTQKLQQELEAANQSLAELRDQR---QGERLEHAAAL---RALQDQVSIQSADA 271
K + L+ ++EAAN++ E+ Q Q + ++ L RA +D++ QS ++
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678
Query: 272 QEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQK 331
+++++ L AE L+ LA+ E+ + QE + L ++ T A+ E L +
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738
Query: 332 DDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEK 391
L +L+E L ++ ++ + + L EL R +A+K +L + + K
Sbjct: 1739 AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK 1798
Query: 392 SQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETL 451
++ +E GAV+ + + + + A+ + EE+L + +E A + +
Sbjct: 1799 AKLQELEGAVKSKFKATISALEAKI-----------GQLEEQLEQEAKERAAANKLVRRT 1847
Query: 452 QQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLK 511
++ ++E+ QV ++ ++++A + ++L + QLE+A+EE + L+
Sbjct: 1848 EKKLKEIFMQVEDERRHADQYKEQMEKANARMKQL---KRQLEEAEEEATRANASRRKLQ 1904
Query: 512 QEVKDTVDGQRILEKKGSAALKDL--------------KRQLHLE 542
+E+ D + L ++ S L +RQLHLE
Sbjct: 1905 RELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLE 1949
Score = 89.4 bits (220), Expect = 9e-18
Identities = 129/616 (20%), Positives = 253/616 (41%), Gaps = 86/616 (13%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQ 66
+ E ++MQA + +L + +K +E + K+ +++E + SK K +
Sbjct: 942 QNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK 1001
Query: 67 EVEVLLSENEMLQAKLHSQEEDFRLQN-------STLMAEFSKERYGKEAGKFSAVSEGQ 119
+ L E+ + + EE+ + +N +M +ER KE + + +
Sbjct: 1002 K----LMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAK 1057
Query: 120 GDPPGGPAPTV--LAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAET--------- 168
G +A + ELK ++ K+E E+LQG + ET
Sbjct: 1058 RKLDGETTDLQDQIAELQAQIDELKLQLAKKE-----EELQGALARGDDETLHKNNALKV 1112
Query: 169 -SRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQK 227
LQ ++A+L E + ++ S + + +K L + EL+ + Q RT++
Sbjct: 1113 VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR 1172
Query: 228 LQQELEAANQSLAELRD---QRQGERLEHAAALRALQDQVSIQS---ADAQEQVEGLLAE 281
Q+ E E ++ Q Q R HA AL L +Q+ A+ ++ +GL +
Sbjct: 1173 EQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETD 1232
Query: 282 NNALRTSLAALEQIQT-----------------AKTQELNMLREQTTGLAAELQQQQAEY 324
N L + L+Q++ AK E + LR + A++LQ +
Sbjct: 1233 NKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNV 1292
Query: 325 EDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA 384
L+ + + + + + L+ QE+ QE+ + L + E+ K
Sbjct: 1293 STLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK------- 1345
Query: 385 METLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIRE---- 440
+LQE+ + +EE R EK+VL +++ +L + KK+ +++L G I
Sbjct: 1346 -NSLQEQQEEEEE---ARKNLEKQVLALQS-------QLADTKKKVDDDL-GTIESLEEA 1393
Query: 441 EKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEER 500
+K ++ E L Q +EE ++ K ++ L + + + V LE+ Q++
Sbjct: 1394 KKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKF 1453
Query: 501 DCHL---KTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDIL 557
D L K+IS+ E +D + + A + + L L R + L+ + +
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAE---------AREKETKALSLARALEEALEAKEEFER 1504
Query: 558 TNSKSRSGLEELVLSE 573
N + R+ +E+L+ S+
Sbjct: 1505 QNKQLRADMEDLMSSK 1520
Score = 79.7 bits (195), Expect = 7e-15
Identities = 97/453 (21%), Positives = 209/453 (46%), Gaps = 54/453 (11%)
Query: 143 WEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFND 202
W + + K LL Q+ E QA+ EEL K+ EK K + ++ + + L +
Sbjct: 835 WRVFTKVKPLL--QVTRQEEELQAK----DEELLKVKEKQTKVEGELEEMERKHQQLLEE 888
Query: 203 SRNKIEELQQRKE--ADHKAQLARTQKLQQELEAA---NQSLAELRDQR----QGERLEH 253
E+LQ E A+ + AR +QELE +S E ++R Q E+ +
Sbjct: 889 KNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKM 948
Query: 254 AAALRALQDQVSIQSADAQE-QVEGLLAEN--NALRTSLAALEQIQTAKTQELNMLREQT 310
A ++ L++Q+ + Q+ Q+E + AE + + LE + +E ++ ++
Sbjct: 949 QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008
Query: 311 TGLAAELQQQQAEYEDL---MGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ 367
+++L +++ + ++L +++ + S L+E L+ + ++L++ ++ + T +LQ
Sbjct: 1009 AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQ 1068
Query: 368 EARKSAEKRKAMLDELAMETLQEKSQHKEEL--GAVRLRHEKEVLGVRARYERELRELHE 425
+ + +A +DEL ++ +++ + + L G H+ L V + ++ EL E
Sbjct: 1069 D---QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125
Query: 426 DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEE 485
D + ++ ++++ + ELE L+ +E+ ++D E R K +E+E
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELED------TLDTTAAQQELRTK----REQE 1175
Query: 486 LQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKR 545
+ +++ LE EE H I ++Q + + AL++L QL ++
Sbjct: 1176 VAELKKALE---EETKNHEAQIQDMRQ--------------RHATALEELSEQLEQAKRF 1218
Query: 546 ADKLQERLQDILTNSKSRSGLEELVLSEMNSPS 578
L++ Q + T++K + E VL ++ + S
Sbjct: 1219 KANLEKNKQGLETDNKELA-CEVKVLQQVKAES 1250
Score = 60.5 bits (145), Expect = 5e-09
Identities = 73/351 (20%), Positives = 160/351 (45%), Gaps = 42/351 (11%)
Query: 293 EQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ---------ESLR 343
E++Q AK +EL ++E+ T + EL++ + +++ L+ +K+ L QLQ E +R
Sbjct: 852 EELQ-AKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMR 910
Query: 344 AN--------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHK 395
A +L L+ +E+E+ Q LQ +K K +A + +L E L E+ +
Sbjct: 911 ARLAAKKQELEEILHDLESRVEEEEERNQILQNEKK---KMQAHIQDLE-EQLDEEEGAR 966
Query: 396 EELGAVRLRHEKEVLGVRAR---YERELRELHEDKKRQEE---ELRGQIREEKARTRELE 449
++L ++ E ++ + E + + ++KK E+ E Q+ EE+ + + L
Sbjct: 967 QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLA 1026
Query: 450 TLQQ----TVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLK 505
++ + +L+ ++ + + E+ ++ +G+ +LQD +L+ +E L
Sbjct: 1027 KIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1086
Query: 506 TISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSG 565
Q D + + + +++L+ Q+ +LQE + S++++
Sbjct: 1087 KKEEELQGALARGDDETLHKNNALKVVRELQAQI-------AELQEDFESEKA-SRNKAE 1138
Query: 566 LEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARVRGKEEPT 616
++ LSE +T+ D ++ + + ++ LR K V + EE T
Sbjct: 1139 KQKRDLSEELEALKTELED--TLDTTAAQQELRTKREQEVAELKKALEEET 1187
Score = 47.0 bits (110), Expect = 5e-05
Identities = 47/191 (24%), Positives = 94/191 (49%), Gaps = 11/191 (5%)
Query: 429 RQEEELRGQIREEKARTRELET-LQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQ 487
RQEEEL+ + EE + +E +T ++ +EE++ + + K +L+ E +
Sbjct: 849 RQEEELQAK-DEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAE 907
Query: 488 DVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE---KKGSAALKDLKRQLHLERK 544
++R +L ++E + + + L+ V++ + +IL+ KK A ++DL+ QL E
Sbjct: 908 EMRARLAAKKQELE---EILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 545 RADKLQERLQDILTNSKSRSGLEE-LVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 603
KLQ L+ + +K + EE L+L + NS + + ++ E+E +
Sbjct: 965 ARQKLQ--LEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022
Query: 604 AVPARVRGKEE 614
A++R K+E
Sbjct: 1023 KNLAKIRNKQE 1033
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 104 bits (260), Expect = 2e-22
Identities = 138/620 (22%), Positives = 272/620 (43%), Gaps = 85/620 (13%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQK---ALSK 61
+ EEE ++++++ ++ T +L ++ K S R L+K S AQK A K
Sbjct: 379 MKEEEIAQLRSRIKQMTTQGEELREQKEK------SERAAFEELEKALSTAQKTEEARRK 432
Query: 62 SKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGD 121
K + ++ E + ++ Q+E R++ + + K+ ++ K + E +
Sbjct: 433 LKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV--DVMKKSSEEQIAKLQKLHEKE-- 488
Query: 122 PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 181
+ E EL +++ E+ + LE S Q E K+S++
Sbjct: 489 ------------LARKEQELTKKLQTREREFQEQMKVALEKS--------QSEYLKISQE 528
Query: 182 LKKKQESFC--RLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSL 239
K++QES L+ +K+ + +S NK+ +LQQ E L L++ L+
Sbjct: 529 -KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQS 587
Query: 240 AELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAK 299
+L + E+ +H ++++ + ++E L + +AL T E++Q K
Sbjct: 588 KDLAVHLEAEKNKH-------NKEITVMVEKHKTELESLKHQQDALWT-----EKLQVLK 635
Query: 300 TQ---ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIG 356
Q E+ LRE+ + E E L+ K+ + E + N + LE+L
Sbjct: 636 QQYQTEMEKLREKC----------EQEKETLLKDKEIIFQAHIEEM--NEKTLEKLDVKQ 683
Query: 357 QEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARY 416
E E L+ EL E K+ K + L L +T + K + + ++ + H+++V + +
Sbjct: 684 TELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEH 743
Query: 417 ERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRL 476
E ++ + K Q +L ++E R + L+ Q VE L+A + +G L
Sbjct: 744 EVSIQRTEKALKDQINQLELLLKE---RDKHLKEHQAHVENLEADIKRSEG-------EL 793
Query: 477 KEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK 536
++A K + Q + E+ + + ++ L+Q++ D ++ +RIL K A ++ K
Sbjct: 794 QQASAKLDVFQSYQ---SATHEQTKAYEEQLAQLQQKLLD-LETERILLTKQVAEVEAQK 849
Query: 537 RQLHLERKRADKLQERLQDILTN-SKSRSGLEELVLS-EMNSPSRTQTGDSSSISSFSYR 594
+ + E A K+Q +QD++ K S +E+ V S S+ + G+ + +
Sbjct: 850 KDVCTELD-AHKIQ--VQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQT---K 903
Query: 595 EILREKESSAVPARVRGKEE 614
+IL EKE+ + R K+E
Sbjct: 904 QILVEKENMILQMREGQKKE 923
Score = 86.3 bits (212), Expect = 8e-17
Identities = 139/661 (21%), Positives = 259/661 (39%), Gaps = 127/661 (19%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
Q + E + Q + ++ EL+ E + E+T L+++ D ++ Q+ L
Sbjct: 1059 QEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL--K 1116
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDF------------RLQNSTLMAEFSKERYGKEAG 110
+K+ V L + L+A L E D +L ++AE K + +
Sbjct: 1117 QKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTS 1176
Query: 111 KFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSR 170
K E LK EK K L K E +
Sbjct: 1177 KLKTTDE-------------------EFQSLKSSHEKSNKSL---------EDKSLEFKK 1208
Query: 171 LQEELAKLSEKLKKKQESFCRLQTEKETLFNDSR-----NKIEELQQRKEADHKAQLART 225
L EELA + KK E+ +T + + S+ ++I Q R +A L +T
Sbjct: 1209 LSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKT 1268
Query: 226 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 285
+ ELEA + L E ++ + L ++Q+ AD +E L+ E AL
Sbjct: 1269 CTV-SELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKAD----IESLVTEKEAL 1323
Query: 286 RTSLAALEQIQTAKTQELNMLREQ-------TTGLAAELQQQQAEYEDLMGQKDDLNSQL 338
+ +Q + K + L+++ T + EL++++ E L Q DLN QL
Sbjct: 1324 QKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL 1383
Query: 339 QESLRANSR-----------------LLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLD 381
Q S+ + + LL+Q+Q++ + + L++E A + +
Sbjct: 1384 QNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS 1443
Query: 382 ELAMETLQEKSQHKEELGAVRLRHE-----------------KEVLGVRARYERELRELH 424
E + +QH+ + ++++ E +E+ R++ E+
Sbjct: 1444 EWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEME 1503
Query: 425 EDK---KRQEEELRGQIREEKARTRELE--TLQQTVE--------------------ELQ 459
+DK +++E L +++ + AR ELE Q+T+E EL
Sbjct: 1504 DDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELV 1563
Query: 460 AQVHSMDGAKGWFERRLKEAEGK----EEELQDVRDQLEQAQEERDCHLKTISSLKQEVK 515
++ + R+KEAE K E ++ ++ +LE ++E + ++ S ++E+K
Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELK 1623
Query: 516 DTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 575
D LE + +A L +LKR+ E+K A ++ L + + E LSE+N
Sbjct: 1624 ALEDR---LESESAAKLAELKRK--AEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELN 1678
Query: 576 S 576
+
Sbjct: 1679 T 1679
Score = 84.0 bits (206), Expect = 4e-16
Identities = 129/605 (21%), Positives = 262/605 (43%), Gaps = 97/605 (16%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA 65
SE E Q+ A+L ++ ++ + +L L+QK+ L+ E + +K+
Sbjct: 789 SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE------RILLTKQV 842
Query: 66 QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGG 125
EVE + + ++ + ++Q LM + K+ E S
Sbjct: 843 AEVEAQKKD-------VCTELDAHKIQVQDLMQQLEKQNSEMEQKVKS------------ 883
Query: 126 PAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKK 185
L + +++E + +++ K++L E+ + ++ + ++E+ L++KL K
Sbjct: 884 -----LTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQ----KKEIEILTQKLSAK 934
Query: 186 QESFCRLQTEKETLFNDSRNKIEELQQR----KEADHKAQLARTQKLQQELEAANQSLAE 241
++S L E ET F + K+E+++Q+ +E K L + KL++ELE L++
Sbjct: 935 EDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQ 994
Query: 242 LRDQRQGERLEHAAALRA-LQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT 300
Q + LE A A A + D VS + +EQ+E +L ++ +
Sbjct: 995 KEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIE--------------SLTEVHRREL 1040
Query: 301 QELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE 360
++ + E+ +L QQ E +++ QLQE + + L +++ G EKE
Sbjct: 1041 NDVISIWEK------KLNQQAEELQEIH------EIQLQEKEQEVAELKQKILLFGCEKE 1088
Query: 361 QLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYEREL 420
++ +E+ ++ K+ L+EL E L++KS H L + + + + + L
Sbjct: 1089 EMNKEITWLKEEGVKQDTTLNEL-QEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSL 1147
Query: 421 RELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAE 480
+E + + Q EL+ E+K + EL + +T +E K E+ K E
Sbjct: 1148 KE-NTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDE------EFQSLKSSHEKSNKSLE 1200
Query: 481 GKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLH 540
K E + + ++L A + C KT + L+ + + ++ I K +A L + H
Sbjct: 1201 DKSLEFKKLSEEL--AIQLDICCKKTEALLEAKTNELIN---ISSSKTNAILSRISHCQH 1255
Query: 541 LERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREI---L 597
R K++E L ++ +SE+ + R T + +++ + S+++ L
Sbjct: 1256 ----RTTKVKEALL-----------IKTCTVSELEAQLRQLTEEQNTL-NISFQQATHQL 1299
Query: 598 REKES 602
EKE+
Sbjct: 1300 EEKEN 1304
Score = 69.7 bits (169), Expect = 8e-12
Identities = 109/613 (17%), Positives = 264/613 (43%), Gaps = 59/613 (9%)
Query: 27 LSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLHSQE 86
L +EL + L+ ++ + K + L K+Q ++ E+ + Q + +
Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIES 1543
Query: 87 EDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEME 146
+ L+N + + ++ F + E + D A + + +K E+E
Sbjct: 1544 LNEVLKNYNQQKDIEHKELVQKLQHFQELGE-EKDNRVKEAEEKILTLENQVYSMKAELE 1602
Query: 147 KEEKRLLWEQLQGLESSKQAETSRLQEEL-----AKLSEKLKKKQESFCRLQTEKETLFN 201
++K L E + SK+ E L++ L AKL+E +K ++ ++
Sbjct: 1603 TKKKEL--EHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIK-------- 1652
Query: 202 DSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQ 261
+ + ++++++E K + +L +L+ + + L ++ + + L +
Sbjct: 1653 --KQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPR 1710
Query: 262 DQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQ 321
++ + QE+ + ++ L++ T K + L + ++ + + +
Sbjct: 1711 SAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMR 1770
Query: 322 AEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQE--LQEARKSAEKRKAM 379
+Y++ + + + ++ E L E+L+E ++ + + +E K+ + K
Sbjct: 1771 CQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQN 1830
Query: 380 LDEL---AMETLQEK-------SQHKEELGAVRLR----HEKEVLGVRARYERELRELHE 425
L+ + +TLQEK Q +EL + +R H E+ + ++YE+
Sbjct: 1831 LENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQM 1890
Query: 426 DKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMD----GAKGWFERRLKEAEG 481
D + + EL + EEK+++ ++ + + ++AQ + ++ GA+ ++ KE
Sbjct: 1891 DGRNKPTELLEENTEEKSKSHLVQ--PKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR 1948
Query: 482 KEEELQDVRDQLEQAQE--ERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 539
+++L+ +R + +Q E +++ + +KQE +D LE K ++ LK L R+
Sbjct: 1949 LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQED-------LELKHNSTLKQLMREF 2001
Query: 540 HLE-RKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSR-----TQTGDSSSISSFSY 593
+ + ++ +L+ +++ T +K++ EL+ S ++ + D ++ Y
Sbjct: 2002 NTQLAQKEQELEMTIKE--TINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRY 2059
Query: 594 REIL--REKESSA 604
EIL RE+E +A
Sbjct: 2060 EEILDAREEEMTA 2072
Score = 62.4 bits (150), Expect = 1e-09
Identities = 128/630 (20%), Positives = 251/630 (39%), Gaps = 113/630 (17%)
Query: 1 MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
+ Q +SEE+ Q QA ++N +R T + L
Sbjct: 5 LKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFT-----------------EQLD 47
Query: 61 KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQ-NSTLMAEFSKERYGKEAGKFSA----- 114
+ +E S + LQ ++ S E FR +L SKE + + + S
Sbjct: 48 EGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDL 107
Query: 115 -VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQE 173
S DPP + M +L + K L ++L+ +E S + + E
Sbjct: 108 DSSTASFDPP--------SDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSE 159
Query: 174 ELA--KLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQE 231
+ ++ ++ KKK + +K S +I EL++ + D +A+ ++
Sbjct: 160 LVTAYQMLQREKKKLQGILSQSQDK------SLRRIAELREELQMDQQAKKHLQEEFDAS 213
Query: 232 LEAANQSLAELRDQ--------RQGE-RLEHAAALRALQDQVSIQSADAQEQVEGLLAEN 282
LE +Q ++ L+ Q R G ++ L L+ Q + + + + +G
Sbjct: 214 LEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVE 273
Query: 283 NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 342
+ TS+ LE +Q ++ N+L+ +Q + + L +K+ L QL E
Sbjct: 274 DG--TSVKTLETLQQRVKRQENLLKR----CKETIQSHKEQCTLLTSEKEALQEQLDE-- 325
Query: 343 RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 402
+LQE+ + K+ E + K ++++L + ++ K ++
Sbjct: 326 --------RLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETL 377
Query: 403 LRHEKEVLGVRARYER------ELRELHEDKKRQ-----EEELRGQIREEKARTR----- 446
E+E+ +R+R ++ ELRE E +R E+ L + E+AR +
Sbjct: 378 EMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEM 437
Query: 447 --ELETLQQTVEE----LQAQV-----HSMDGAKGWFERRL--------KEAEGKEEEL- 486
+++T+++T EE LQ ++ +D K E ++ KE KE+EL
Sbjct: 438 DEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELT 497
Query: 487 -------QDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKK-----GSAALKD 534
++ ++Q++ A E+ IS K++ + + L+KK L+D
Sbjct: 498 KKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRD 557
Query: 535 LKRQLHLERKRADKLQERLQDILTNSKSRS 564
L+++ R R +L+ L+ L +K++S
Sbjct: 558 LQQEAETYRTRILELESSLEKSLQENKNQS 587
Score = 62.4 bits (150), Expect = 1e-09
Identities = 100/449 (22%), Positives = 193/449 (42%), Gaps = 46/449 (10%)
Query: 25 YQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLHS 84
Y +E G + +K++ L + ++ +K L + + +E E + S EM +
Sbjct: 1718 YTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKE-ETVSSHFEM---RCQY 1773
Query: 85 QEEDFRLQNSTL-------MAEFSKERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLA 137
QE +L+++ M +E ++ K+S + + GG + A L
Sbjct: 1774 QERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKN-NIQAKQNLE 1832
Query: 138 EVELKWEMEKEEKRL----LWEQLQGLESS--KQAETSRLQ-EELAKLSEKLKKKQESFC 190
V + +EK L L ++++ L+S +Q E R++ EEL EKL+ Q+
Sbjct: 1833 NVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQM-- 1890
Query: 191 RLQTEKETLFNDSRNKIEEL-QQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGE 249
D RNK EL ++ E K+ L + KL +EA + L + E
Sbjct: 1891 -----------DGRNKPTELLEENTEEKSKSHLVQP-KLLSNMEAQHNDLEFKLAGAERE 1938
Query: 250 RLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQ--IQTAKTQELNML- 306
+ + + LQ + + + Q+++E L E + R EQ ++ L L
Sbjct: 1939 KQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLM 1998
Query: 307 REQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLT--- 363
RE T LA + Q+ + ++ + + ++ ++L ES + + L L++I ++ + L
Sbjct: 1999 REFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQL--LKKIAEKDDDLKRTA 2056
Query: 364 ---QELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYEREL 420
+E+ +AR+ K + +E LQ+K Q K E ++ ++ + ++
Sbjct: 2057 KRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKT 2116
Query: 421 RELHEDKKRQEEELRGQIREEKARTRELE 449
L D K +E+E R QI + R ++ E
Sbjct: 2117 T-LISDSKLKEQEFREQIHNLEDRLKKYE 2144
Score = 46.2 bits (108), Expect = 9e-05
Identities = 72/332 (21%), Positives = 143/332 (43%), Gaps = 42/332 (12%)
Query: 48 LDKEFSKAQKALSKSKKAQEVEV--LLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERY 105
L+++ + L + K+ VE+ L S+ E LQA Q+ D R + + L+ E ++E+
Sbjct: 1852 LEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQAL---QQMDGRNKPTELLEENTEEK- 1907
Query: 106 GKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEME--KEEKRLLWEQLQGLESS 163
K V P +L+ M +L++++ + EK+ L +++ L+
Sbjct: 1908 ----SKSHLVQ-----------PKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKD 1952
Query: 164 KQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 223
+ Q+EL L ++ +++E +++ E+E L + +++L + + QLA
Sbjct: 1953 LRMLRKEHQQELEILKKEYDQEREE--KIKQEQEDLELKHNSTLKQLMR----EFNTQLA 2006
Query: 224 RTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENN 283
+ + QELE + + + E LE + Q++ + E+ + L
Sbjct: 2007 QKE---QELEMTIKETINKAQEVEAELLE------SHQEETNQLLKKIAEKDDDLKRTAK 2057
Query: 284 ALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLR 343
L A E+ TAK ++L E+ + QQ+ E E+ G + +LQ L
Sbjct: 2058 RYEEILDAREEEMTAKVRDLQTQLEELQ----KKYQQKLEQEENPGNDNVTIMELQTQLA 2113
Query: 344 ANSRLLEQLQEIGQEKEQLTQELQEARKSAEK 375
+ L+ + QE + L++ K EK
Sbjct: 2114 QKTTLISDSKLKEQEFREQIHNLEDRLKKYEK 2145
Score = 35.8 bits (81), Expect = 0.12
Identities = 51/239 (21%), Positives = 94/239 (39%), Gaps = 30/239 (12%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
QAL + + + +LLE T S ++ + + + D EF A K
Sbjct: 1885 QALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS----NMEAQHNDLEFKLAGAEREKQ 1940
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
K +E+ L + ML+ K H QE + L E+ +ER K + + Q D
Sbjct: 1941 KLGKEIVRLQKDLRMLR-KEHQQELEI------LKKEYDQEREEK-------IKQEQED- 1985
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
+ L ++ +E L ++ Q LE + + ++ QE A+L E
Sbjct: 1986 -----------LELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESH 2034
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAE 241
+++ + EK+ + + EE+ +E + A++ Q +EL+ Q E
Sbjct: 2035 QEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLE 2093
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 103 bits (258), Expect = 4e-22
Identities = 139/632 (21%), Positives = 271/632 (42%), Gaps = 84/632 (13%)
Query: 8 EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
+E Q +Q+ +L +++ L+ EL++ E+ S R+++ +E + ++ L++ + ++
Sbjct: 1602 QELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQI----EELQRQKEHLTQDLERRD 1657
Query: 68 VEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGPA 127
E++L + + + + L+ + S G+E + + + + GP+
Sbjct: 1658 QELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPS 1717
Query: 128 PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQE---ELAKLSEKLKK 184
+ +R E ++ + K+ E QE EL +L ++L++
Sbjct: 1718 --------------------KAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQ 1757
Query: 185 KQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRD 244
+ + R E L + +I LQQ+ Q+ +++ E QSL D
Sbjct: 1758 QLQGLHRKVGETSLLLSQREQEIVVLQQQ-----------LQEAREQGELKEQSLQSQLD 1806
Query: 245 QRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELN 304
+ Q + L ALQ + AQ Q E + + +AL+ +L + EL
Sbjct: 1807 EAQRALAQRDQELEALQQ----EQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQ 1862
Query: 305 MLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQ 364
+EQ L EL + + L DL ++ +E +A L +Q E QE E T+
Sbjct: 1863 DHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETR 1922
Query: 365 ELQ----EARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYEREL 420
LQ +A+ ++R L+ L E+ + S+H+EE R +E LG
Sbjct: 1923 ALQDSWLQAQAVLKERDQELEALRAES--QSSRHQEEAARARAEALQEALG--------- 1971
Query: 421 RELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAE 480
+ H + +E+ L Q ++ TLQ +++ QA ++ A R++E E
Sbjct: 1972 -KAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEA-----LRIQEGE 2025
Query: 481 GKEEELQDVRD--QLEQAQEERDCHLK--------TISSLKQEVKDTV--DGQRILEKKG 528
++++L+ D QL+QA +RD L+ SL Q V++ + + Q + +++
Sbjct: 2026 IQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQERE 2085
Query: 529 SAALKDLKRQL-HLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSS 587
++ L + + L+ A K QE L+ L ++ R+ LE L S SP Q+ S
Sbjct: 2086 EEEIRGLHQSVRELQLTLAQKEQEILE--LRETQQRNNLEALPHSHKTSPMEEQSLKLDS 2143
Query: 588 ISSFSYREI------LREKESSAVPARVRGKE 613
+ RE+ LR+ E+ + R + ++
Sbjct: 2144 LEPRLQRELERLQAALRQTEAREIEWREKAQD 2175
Score = 102 bits (253), Expect = 1e-21
Identities = 101/432 (23%), Positives = 201/432 (46%), Gaps = 51/432 (11%)
Query: 149 EKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLK----KKQESFCRLQTEKETLFNDSR 204
E +L + QG + +Q E E +L E L K+ ES L T +E L +S
Sbjct: 495 ELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREAL--ESS 552
Query: 205 NKIEELQQRKEADHKAQLARTQKLQQELEAANQSL-AELRDQRQGERLEHAAALRALQDQ 263
+ EL ++++ + A LAR ++ EL ++ +L E+ D R A L AL +
Sbjct: 553 HLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAA-----AVKLSALNEA 607
Query: 264 VSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAE 323
+++ +Q+ L EN ++ + + A EQ + A L +L + +
Sbjct: 608 LALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNA--------------LQVDLAEAEKR 653
Query: 324 YEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDEL 383
E L + L +QLQ++ A + L L++I +EKE++ ++L E+R E L
Sbjct: 654 REALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQL--- 710
Query: 384 AMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKA 443
E L ++++ +EE+ A ++ ++ ++ +A E L+ + D++ E+L+G
Sbjct: 711 --EQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQG------- 761
Query: 444 RTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQ--------DVRDQLEQ 495
+ E L+ ++ E Q Q ++ KG E +++ +E +Q ++ + Q
Sbjct: 762 LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQ 821
Query: 496 AQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQD 555
A++ERD + ++ +QE K ++ Q+ +K L++ E++R+ QE +
Sbjct: 822 AEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLRE-----KWEKERSWHQQELAKA 876
Query: 556 ILTNSKSRSGLE 567
+ + + + LE
Sbjct: 877 LESLEREKMELE 888
Score = 97.4 bits (241), Expect = 3e-20
Identities = 122/564 (21%), Positives = 252/564 (44%), Gaps = 62/564 (10%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA 65
+EE +QA L +++ ++ +L ++ + + ++ L +E + ++ L+++
Sbjct: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARA--V 728
Query: 66 QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGG 125
QE E L+ E L+ +L + E D R + + S + E+ F A +
Sbjct: 729 QEKEALVREKAALEVRLQAVERD-RQDLAEQLQGLSSAKELLESSLFEAQQQNS------ 781
Query: 126 PAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKK 185
+ + ++E++ + + K ++ +++ L+ E S+ ++E + +L +
Sbjct: 782 -----VIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQA 836
Query: 186 QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART--------QKLQQELEAANQ 237
++ +++ N++ E +++ + H+ +LA+ +L+ L+
Sbjct: 837 EQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQT 896
Query: 238 SLAELRDQRQGERLEHAAALRALQ-----DQVSI---------QSADAQEQVEGLLAENN 283
+ ++ QR+ ER + +AL +Q ++VS+ + ADA +Q+E L +
Sbjct: 897 EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMK 956
Query: 284 ALR-----TSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQA----EYEDLMGQKDDL 334
+ T+ Q+Q A+ + R+ LAA LQ++ + + DL Q +DL
Sbjct: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAA-LQEESSSLLQDKMDLQKQVEDL 1015
Query: 335 NSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME------TL 388
SQL + + RL+E QE+ QEK + TQE +K E+ KA L ME L
Sbjct: 1016 KSQL-VAQDDSQRLVE--QEV-QEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVL 1071
Query: 389 QE-KSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRE 447
QE S ++EL A+R + +E G + ++ L ++ K +E + + +E E
Sbjct: 1072 QEADSIRQQELSALR-QDMQEAQGEQKELSAQMELLRQEVKEKEADF---LAQEAQLLEE 1127
Query: 448 LETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTI 507
LE T ++L+A + + + + RL+ E + E L + QAQ +
Sbjct: 1128 LEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL-ASLY 1186
Query: 508 SSLKQEVKDTVDGQRILEKKGSAA 531
S+L+Q + + + L G +A
Sbjct: 1187 SALQQALGSVCESRPELSGGGDSA 1210
Score = 93.2 bits (230), Expect = 6e-19
Identities = 129/628 (20%), Positives = 259/628 (41%), Gaps = 98/628 (15%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQ-------LSDELRKNGVELTSLRQKVAYLDKEFSKAQK 57
L+ E +R+Q L+ L + L + L + +E LRQ+ + ++A++
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 58 ALSK-SKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSK--ERYGKEAGKFSA 114
++++ S ++ +++ KL + E L L + + E + A
Sbjct: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 115 VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSK---QAETSRL 171
+ + + LAE E + E E+ L QLQ E + QA+ +
Sbjct: 636 AEQARN----------ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDI 685
Query: 172 QEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQE 231
QEE ++ +KL + + T+ E L +++ + EE+ R + +A + L+
Sbjct: 686 QEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ-EEVLARAVQEKEALVREKAALEVR 744
Query: 232 LEAANQSLAELRDQRQG-------------ERLEHAAALRALQDQVSIQSADAQEQVEGL 278
L+A + +L +Q QG E + + + + Q+ +Q + E +
Sbjct: 745 LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVI 804
Query: 279 LAENNALRTSL--------------------------AALEQIQTAKTQELNMLREQTTG 312
E L+ L ALEQ + A +E+N LRE+
Sbjct: 805 QGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEK 864
Query: 313 LAAELQQQQAE-YEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARK 371
+ QQ+ A+ E L +K +L +L+E + Q +E E+ Q L + +
Sbjct: 865 ERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREE---ERTQAESALCQMQL 921
Query: 372 SAEKRKAMLDELAMETLQEKSQHKEELGAVRLR------HEKEVLGV-RARYERELRELH 424
EK + L E ++T +E + ++L +R E+E G+ + + + REL
Sbjct: 922 ETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELK 981
Query: 425 EDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEE 484
E ++ ++L E + ++ LQ+ VE+L++Q+ + D ++ E+ ++E + +
Sbjct: 982 EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQ 1041
Query: 485 ELQDVRDQLEQ------------------AQEERDCHLKTISSLKQEVKDTVDGQRILEK 526
E ++ +LE+ QE + +S+L+Q++++ E+
Sbjct: 1042 EYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQG-----EQ 1096
Query: 527 KGSAALKDLKRQLHLERKRADKLQERLQ 554
K +A +L RQ ++ K AD L + Q
Sbjct: 1097 KELSAQMELLRQ-EVKEKEADFLAQEAQ 1123
Score = 91.7 bits (226), Expect = 2e-18
Identities = 148/643 (23%), Positives = 271/643 (42%), Gaps = 99/643 (15%)
Query: 9 EFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQEV 68
E Q +Q QL + + + + EL L + +A L +A+ L + + E
Sbjct: 1286 ELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAE--LQRMEAQGER 1343
Query: 69 EVLLSENEMLQAKL-HSQ----------------EEDFRLQNSTLMAEFSKERYGKEAGK 111
E+L + E L A++ H Q EED R S L + E E +
Sbjct: 1344 ELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSAL--KLKNEEVESERER 1401
Query: 112 FSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRL 171
A+ E QG+ + + L L +EE L Q+Q LE ++ + + L
Sbjct: 1402 AQALQE-QGELKVAQGKALQENLALLTQTLA--EREEEVETLRGQIQELEKQREMQKAAL 1458
Query: 172 QEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQE 231
+ LS LKK+ + LQ E+ I+EL++ + +A Q+ +Q+
Sbjct: 1459 E----LLSLDLKKRNQEV-DLQQEQ----------IQELEKCRSVLEHLPMA-VQEREQK 1502
Query: 232 LEAANQSLAELRDQRQGER--LEHAAALRALQDQVSI----QSADAQEQVEGL------L 279
L + + EL R+ +R LEH +DQ+ Q D ++Q+ L L
Sbjct: 1503 LTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALEL 1562
Query: 280 AENN-ALRTSLAALEQIQTAKTQELNMLREQTTGL---AAELQQQQAEYEDLMGQKDDLN 335
EN+ + +++++ + + L T L + ELQ Q ++ DL L
Sbjct: 1563 EENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLA 1622
Query: 336 SQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHK 395
+LQE + EQ++E+ ++KE LTQ+L+ + +K + L + ++ +
Sbjct: 1623 RELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILE 1682
Query: 396 EELGAVRLRHEKEVLGVRARYEREL-RELHEDKKRQEEELRGQI-----------REEKA 443
E+L ++L + G +R+L +E E+ K + RG + +E +
Sbjct: 1683 EDLEQIKLSLRER--GRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVEC 1740
Query: 444 RTRELETLQQTVEELQAQVHSMDGAKG--------------WFERRLKEA----EGKEEE 485
+ + LQ+ ++L+ Q+ + G +++L+EA E KE+
Sbjct: 1741 QQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQS 1800
Query: 486 LQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLE-RK 544
LQ D+ ++A +RD L+ + +Q+ + GQ K+ + AL+ Q H+ ++
Sbjct: 1801 LQSQLDEAQRALAQRDQELEALQQEQQQAQ----GQEERVKEKADALQGALEQAHMTLKE 1856
Query: 545 RADKLQE------RLQDILTNSKSRSGLEELVLSEMNSPSRTQ 581
R +LQ+ RL++ L R E VL ++ + SR Q
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQ 1899
Score = 75.5 bits (184), Expect = 1e-13
Identities = 105/454 (23%), Positives = 187/454 (41%), Gaps = 57/454 (12%)
Query: 26 QLSDELRKNGVELTSLRQKVAYLDKEFSKAQKAL-------SKSKKAQEVEVLLSENEML 78
+L +EL G + +L + + L E + +KAL ++ + EVE ++ L
Sbjct: 1870 RLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWL 1929
Query: 79 QAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAE 138
QA+ +E D L+ L AE R+ +EA + A + + A L +
Sbjct: 1930 QAQAVLKERDQELE--ALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQ 1987
Query: 139 VELKWEME-------------KEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKK 185
EL +E + R L E L+ E Q + R QE++ +L + L ++
Sbjct: 1988 AELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR 2047
Query: 186 QESFCRLQTEKETLFNDS------RNKIEELQ----QRKEADHKAQLARTQKLQQELEAA 235
E R Q E+E L S N I+E Q +R+E + + ++LQ L
Sbjct: 2048 DEEL-RHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQK 2106
Query: 236 NQSLAELRDQRQGERLE---HAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAAL 292
Q + ELR+ +Q LE H+ +++Q S++ + +++ L A A
Sbjct: 2107 EQEILELRETQQRNNLEALPHSHKTSPMEEQ-SLKLDSLEPRLQRELERLQAALRQTEAR 2165
Query: 293 EQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQ- 351
E K Q+L + QT + LQ+ + + ++D +LQ+ L R LE+
Sbjct: 2166 EIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKE 2225
Query: 352 ---------LQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKE------ 396
E+G E Q +Q S + + D + ++ +++ +H +
Sbjct: 2226 RLHSPGATSTAELGSRGE---QGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARL 2282
Query: 397 ELGAVRL-RHEKEVLGVRARYERELRELHEDKKR 429
E+ RL RH ++ + ERE R+L + R
Sbjct: 2283 EIDRSRLQRHNVQLRSTLEQVERERRKLKREAMR 2316
Score = 72.4 bits (176), Expect = 1e-12
Identities = 140/604 (23%), Positives = 249/604 (41%), Gaps = 100/604 (16%)
Query: 3 QALSEEEFQR-MQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK 61
Q L E+E +Q QL E + +L + R++ +L +L+++ + L ++ QK +
Sbjct: 958 QKLKEQETTGILQTQLQEAQR---ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Query: 62 SKK---AQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEG 118
K AQ+ L E E+ Q KL +E R+Q E +E+
Sbjct: 1015 LKSQLVAQDDSQRLVEQEV-QEKLRETQEYNRIQK-----ELEREKAS------------ 1056
Query: 119 QGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQ---AETSRLQEEL 175
+ L E E + + +E + ++L L Q E L ++
Sbjct: 1057 -------------LTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQM 1103
Query: 176 AKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAA 235
L +++K+K+ F L E + L + I E Q R A AQ A+ +LQ L +
Sbjct: 1104 ELLRQEVKEKEADF--LAQEAQLLEELEASHITEQQLR--ASLWAQEAKAAQLQLRLRST 1159
Query: 236 NQSLAELR-DQRQGERLEHAAALRALQDQVSIQSA---------------DAQEQVEGLL 279
L L +Q+ G + + A L +L ++Q A D+ V GL
Sbjct: 1160 ESQLEALAAEQQPGNQAQAQAQLASLYS--ALQQALGSVCESRPELSGGGDSAPSVWGLE 1217
Query: 280 AENNALRTS------LAALEQIQTAKT-----QELNMLREQTTGLAAELQQQQAEYEDLM 328
+ N R+ L AL A Q+L ++ L ++Q+ + D
Sbjct: 1218 PDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTE 1277
Query: 329 GQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETL 388
+K ++++LQ+ R S+ E+ + ++ L EL E ++ ++ L ++ +
Sbjct: 1278 AEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRM 1337
Query: 389 QEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTREL 448
+ + + +E L A + +V ++A E R EE+LR K + E+
Sbjct: 1338 EAQGE-RELLQAAKENLTAQVEHLQAAVV-EARAQASAAGILEEDLRTARSALKLKNEEV 1395
Query: 449 ETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTIS 508
E+ ++ + LQ Q LK A+GK LQ+ L Q ER+ ++T+
Sbjct: 1396 ESERERAQALQEQ------------GELKVAQGK--ALQENLALLTQTLAEREEEVETLR 1441
Query: 509 SLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEE 568
QE ++ QR ++K AAL+ L L + D QE++Q++ K RS LE
Sbjct: 1442 GQIQE----LEKQREMQK---AALELLSLDLKKRNQEVDLQQEQIQEL---EKCRSVLEH 1491
Query: 569 LVLS 572
L ++
Sbjct: 1492 LPMA 1495
Score = 70.9 bits (172), Expect = 3e-12
Identities = 98/436 (22%), Positives = 182/436 (41%), Gaps = 68/436 (15%)
Query: 153 LWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQ 212
L E L + Q E LQ+ + +++ + ++ ++ + + +L DS I
Sbjct: 323 LMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDS--SIFSQFD 380
Query: 213 RKEADHKAQLART---------QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQ-- 261
++AD L R+ Q L+Q+L +++ L+ Q E A + LQ
Sbjct: 381 YQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKL 440
Query: 262 ----DQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAEL 317
D ++ Q+ D Q +V+ L E L+ + L Q +L +L ++ L
Sbjct: 441 TGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQ-------QLEVLEQEAWRLRRVN 493
Query: 318 QQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRK 377
+ Q + + GQK++ +L ++R RL E L + ++ + EL R++ E
Sbjct: 494 VELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALE--- 550
Query: 378 AMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDK---KRQEEEL 434
S H E G + + + EV AR E+ + EL + K + +L
Sbjct: 551 --------------SSHLE--GELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADL 594
Query: 435 RGQIREEKARTREL--------ETLQQTVEELQ---AQVHSMDGAKGWFERRLKEAEGKE 483
R + A L + L Q EE Q +++ + + A+ + L EAE +
Sbjct: 595 RAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRR 654
Query: 484 EELQD----VRDQLEQAQE---ERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK 536
E L + + QL++A+E E L+ I K+E++ + R ++ + L+
Sbjct: 655 EALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLE--- 711
Query: 537 RQLHLERKRADKLQER 552
QLH E KR +++ R
Sbjct: 712 -QLHQEAKRQEEVLAR 726
Score = 56.2 bits (134), Expect = 9e-08
Identities = 111/519 (21%), Positives = 209/519 (40%), Gaps = 97/519 (18%)
Query: 136 LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCR-LQT 194
LAEV + + E+ ++ + L+ + SR ++EL + + + +QE F L+
Sbjct: 113 LAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKG 172
Query: 195 EKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHA 254
E L + R + R L+ + A ++ L EL+ + RL +
Sbjct: 173 EHGRLLSLWREVVT--------------FRRHFLEMK-SATDRDLMELKAEHV--RLSGS 215
Query: 255 AALRALQDQVSIQSA--------DAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNML 306
L+ V QS D +E + LL L LE+ ++QEL L
Sbjct: 216 LLTCCLRLTVGAQSREPNGSGRMDGREPAQLLL-----LLAKTQELEKEAHERSQELIQL 270
Query: 307 REQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQ----EIGQEKEQL 362
+ Q AELQ + E L+ Q N ++ ++A +E L+ E+ + + L
Sbjct: 271 KSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASL 330
Query: 363 TQELQEARKSAEKRKAMLDELAME---TLQEKSQHKEEL--------------GAVRLRH 405
++ QE + S ++ + ++ +E + + S H+ L L
Sbjct: 331 SRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTL 390
Query: 406 EKEVLGVRARYERELRE-----------LHEDKKRQEEELRGQIREEKARTRELETLQQT 454
+ VL R + ++LR+ L + + EEE + + + T E +TL
Sbjct: 391 VRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQ 450
Query: 455 VEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEV 514
+LQ +V S+ KE E ++ +++R QLE ++E L+ ++ Q
Sbjct: 451 TVDLQGEVDSLS----------KERELLQKAREELRQQLEVLEQEA-WRLRRVNVELQLQ 499
Query: 515 KDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEM 574
D+ GQ+ ++ + +LHL + ++LQE L + +K L EL+
Sbjct: 500 GDSAQGQK----------EEQQEELHLAVRERERLQEMLMGL--EAKQSESLSELI---- 543
Query: 575 NSPSRTQTGDSSSISSFSYREILREKESSAVPARVRGKE 613
T + SS E+LR++++ A R ++
Sbjct: 544 -------TLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Score = 35.0 bits (79), Expect = 0.21
Identities = 69/337 (20%), Positives = 134/337 (39%), Gaps = 54/337 (16%)
Query: 14 QAQLLELRT----NNYQL------SDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK 63
+ ++LELR NN + + + + ++L SL + L +E + Q AL +++
Sbjct: 2107 EQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPR---LQRELERLQAALRQTE 2163
Query: 64 --------KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFS-A 114
KAQ++ + L++ + + L QE LQ S L + ++R E A
Sbjct: 2164 AREIEWREKAQDLALSLAQTKASVSSL--QEVAMFLQASVLERDSEQQRLQDELELTRRA 2221
Query: 115 VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEE 174
+ + + PG + L V+L G S +AE S E
Sbjct: 2222 LEKERLHSPGATSTAELGSRGEQGVQL-----------------GEVSGVEAEPSPDGME 2264
Query: 175 LAKLSEKLKKKQESFCRLQTEKETLFNDS---RNKIEELQQRKEADHKAQLARTQKLQQE 231
++L+ Q++ RL+ ++ L + R+ +E++++ + + + Q E
Sbjct: 2265 KQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLE 2324
Query: 232 LEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSAD---AQEQVEGLLAENNALRTS 288
+ A S +D R G++ A + LQ +V + A ++Q + + +
Sbjct: 2325 ISKATASSPTQQDGR-GQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRE 2383
Query: 289 LAALEQ------IQTAKTQELNMLREQTTGLAAELQQ 319
LA L + A+ E +L +T L L Q
Sbjct: 2384 LAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 100 bits (248), Expect = 5e-21
Identities = 138/582 (23%), Positives = 253/582 (43%), Gaps = 123/582 (21%)
Query: 137 AEVELKWEMEKEEKRLLWEQLQGL---------ESSKQAETSRLQ---------EELAKL 178
AE K+E E+EE R ++ L E QAE SRL+ E++ L
Sbjct: 194 AEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHL 253
Query: 179 SEKLKK------KQESFCRLQ-TEKET-------LFNDSRNKIEELQQRKEADHKAQLAR 224
++ KK KQ S +Q TEKE L +SR+K+ +L+++ + +
Sbjct: 254 EQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKL-------Q 306
Query: 225 TQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQS---ADAQEQVEGLLAE 281
++ L+Q +E + EL D + + + +AL++ + I + E+ E + E
Sbjct: 307 SENLKQSIEKQHHLTKELEDIKVSLQ-RSVSTQKALEEDLQIATKTICQLTEEKETQMEE 365
Query: 282 NNALR-----------TSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ 330
+N R T++ +LE++ + Q L +Q L ELQ++ +E E++
Sbjct: 366 SNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEM--T 423
Query: 331 KDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDEL-AMETLQ 389
K N +++ LE+L+++ EKE L E ++ K AE+ K EL + +
Sbjct: 424 KLTNNKEVE---------LEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAR 474
Query: 390 EKSQHKEELGAVRLRHEKEVLGVRARYERELRELH---EDKKRQEEELRGQIREEKARTR 446
EK H E+ + ++ Y +E+++L E++K + EL + +
Sbjct: 475 EKEVHDLEIQLTAITTSEQY------YSKEVKDLKTELENEKLKNTELTSHCNKLSLENK 528
Query: 447 EL--ETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEE-------ELQDVRDQLEQAQ 497
EL ET T+ EL+ Q ++ K ER LK+ E +E EL+ VR++L+Q +
Sbjct: 529 ELTQETSDMTL-ELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKR 587
Query: 498 EERDCHL-----------KTISSLKQEVKDTVDGQRILEKKGSAALKDL--------KRQ 538
+E C L K + + + +++ + L+KKG+A K L K +
Sbjct: 588 DEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLE 647
Query: 539 LHLERKR------ADKLQERLQD--------ILTNSKSRSGLEELVLSEMNSPSRTQTGD 584
L LE + D Q+ ++D + K++ +E V + R Q
Sbjct: 648 LELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKI 707
Query: 585 SSSIS-----SFSYREILREKESSAVPARVRGKEEPTAPASL 621
+ ++ Y +I+ E++S + + +E+ + ASL
Sbjct: 708 AEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASL 749
Score = 86.7 bits (213), Expect = 6e-17
Identities = 124/575 (21%), Positives = 248/575 (43%), Gaps = 80/575 (13%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQ 66
E + + + L E R QL ++ + L +K +L KE + +L +S Q
Sbjct: 279 ENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQ 338
Query: 67 EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGP 126
+ L E+ + K Q + + T M E +K R A V+E +
Sbjct: 339 KA---LEEDLQIATKTICQLTE---EKETQMEESNKAR----AAHSFVVTEFE------- 381
Query: 127 APTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQ 186
TV + L E + +EK E +QL+ L Q ++S L EE+ KL+ + +
Sbjct: 382 -TTVCSLEELLRTEQQ-RLEKNE-----DQLKILTMELQKKSSEL-EEMTKLTNNKEVEL 433
Query: 187 ESFCRLQTEKETLFNDSRN--KIEE------------LQQRKEADHKAQLARTQKLQQEL 232
E ++ EKETL +++ KI E LQ R++ H ++ T E
Sbjct: 434 EELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSE- 492
Query: 233 EAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAAL 292
+ ++ + +L+ + + E+L++ L + +++S+++ + ++ + E + +
Sbjct: 493 QYYSKEVKDLKTELENEKLKNTE-LTSHCNKLSLENKELTQETSDMTLELKNQQEDINNN 551
Query: 293 EQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQL 352
++ + +++ L+E T L EL+ + E+L ++D++ +L +S + L +Q+
Sbjct: 552 KKQEERMLKQIENLQETETQLRNELEYVR---EELKQKRDEVKCKLDKSEENCNNLRKQV 608
Query: 353 QEIGQEKEQLTQELQEARK--SAEKRKAMLDELAMETLQ-EKSQHKEELGAVRLRHEKEV 409
+ + E+L QE + +K +AE ++ + E+ + L+ E K++ G + ++KE+
Sbjct: 609 ENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEI 668
Query: 410 LGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEE-LQAQVHSMDGA 468
EDKK EE L ++ + K E LQ+ +++ Q ++ M
Sbjct: 669 ---------------EDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVAL 713
Query: 469 KGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKG 528
++ + Q ++ EERD L S +QE I
Sbjct: 714 -----------------MEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNL 756
Query: 529 SAALKDLKRQLHLERKRADKLQERLQDILTNSKSR 563
A L +K+QL +ER+ +KL+ ++ K +
Sbjct: 757 KAELLSVKKQLEIEREEKEKLKREAKENTATLKEK 791
Score = 71.2 bits (173), Expect = 3e-12
Identities = 101/490 (20%), Positives = 205/490 (41%), Gaps = 70/490 (14%)
Query: 155 EQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIE----EL 210
E L+ + SR+ +L K +EK+KK + S +KE+ ++R IE +
Sbjct: 89 EGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAI 148
Query: 211 QQRKEADHKAQLARTQKLQQELEA-----ANQSLAELRDQRQGERLEHAAALRALQDQVS 265
Q+ + + K L + +Q+ + A + L L + E +++
Sbjct: 149 QELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETR 208
Query: 266 IQSADAQEQVEGLL---------AENN------ALRTSLAALEQIQTAKTQELNMLREQT 310
D +E ++ AEN+ L+ ++ ++ +E+N +Q
Sbjct: 209 QVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQV 268
Query: 311 TGLAAELQQQQAEYED---LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQ 367
+ L ++ +++ + +D L+ + D +QL+E + S E L++ +++ LT+EL+
Sbjct: 269 SLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQS---ENLKQSIEKQHHLTKELE 325
Query: 368 EAR----KSAEKRKAMLDELAMET------LQEKSQHKEELGAVRLRHE---KEVLGVRA 414
+ + +S +KA+ ++L + T +EK EE R H E
Sbjct: 326 DIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVC 385
Query: 415 RYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKG---- 470
E LR + ++ E++L+ E + ++ ELE + + + ++ + G
Sbjct: 386 SLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKET 445
Query: 471 ------WFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQ----EVKDTVDG 520
FE+ +E +G E+EL + E+ + + L I++ +Q EVKD +
Sbjct: 446 LLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKD-LKT 504
Query: 521 QRILEKKGSAALKDLKRQLHLERKRAD--------KLQERLQDILTNSKSRSGLEELVLS 572
+ EK + L +L LE K +L+ + +DI N K EE +L
Sbjct: 505 ELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQ----EERMLK 560
Query: 573 EMNSPSRTQT 582
++ + T+T
Sbjct: 561 QIENLQETET 570
Score = 63.2 bits (152), Expect = 7e-10
Identities = 95/405 (23%), Positives = 182/405 (44%), Gaps = 59/405 (14%)
Query: 9 EFQRMQAQLLELR--TNNYQLS-DELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA 65
E Q+ ++L E+ TNN ++ +EL+K + ++ + Y +K+F K + L K
Sbjct: 411 ELQKKSSELEEMTKLTNNKEVELEELKK----VLGEKETLLYENKQFEKIAEEL----KG 462
Query: 66 QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQG----D 121
E E++ +LQA+ + D +Q + + S++ Y KE E + +
Sbjct: 463 TEQELI----GLLQAR-EKEVHDLEIQLTAITT--SEQYYSKEVKDLKTELENEKLKNTE 515
Query: 122 PPGGPAPTVLAPMPLAE------VELKWEME------KEEKRLLWEQLQGLESSKQAETS 169
L L + +ELK + E K+E+R+L +Q++ L+ ++ +
Sbjct: 516 LTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERML-KQIENLQETE----T 570
Query: 170 RLQEELAKLSEKLKKKQESF-CRLQTEKETLFN-----DSRNK-IEELQQRKEADHKAQL 222
+L+ EL + E+LK+K++ C+L +E N +++NK IEELQQ +A K
Sbjct: 571 QLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGT 630
Query: 223 ARTQ----------KLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQ 272
A ++ KL+ ELE+A Q E+ D Q E + + L ++V A
Sbjct: 631 AESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIAD 690
Query: 273 EQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKD 332
E V+ + + +A + + + + + E+ + ++ E L +
Sbjct: 691 EAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLE 750
Query: 333 DLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRK 377
S L+ L + + LE +E EKE+L +E +E + +++K
Sbjct: 751 IELSNLKAELLSVKKQLEIERE---EKEKLKREAKENTATLKEKK 792
Score = 50.4 bits (119), Expect = 5e-06
Identities = 84/412 (20%), Positives = 176/412 (42%), Gaps = 78/412 (18%)
Query: 246 RQGERLEHAAALRALQ-----DQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT 300
+ GE ++ AL+ + +QV QE ++ EN+ L ++ +
Sbjct: 57 KNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSE------GLSRVYSKLY 110
Query: 301 QELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE 360
+E +++ AEL+Q++++ ++ + +QE N ++ +L+E QE +
Sbjct: 111 KEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENK 170
Query: 361 QLTQELQEAR-----------KSAEKRKAMLDE-------------------LAMETLQE 390
L +E R +SAEK K E A E L+
Sbjct: 171 DLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRV 230
Query: 391 KSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELET 450
++++ +L+ + E + E+E ++ DK++Q L QI E++ + ++L
Sbjct: 231 QAENSRLEMHFKLKEDYEKI---QHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTF 287
Query: 451 LQQTVEELQAQVHSMDGAKGWFERRLKEAEGKE----EELQDVRDQLEQA-------QEE 499
L +EE + +V+ ++ LK++ K+ +EL+D++ L+++ +E+
Sbjct: 288 L---LEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEED 344
Query: 500 RDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKD-------LKRQLHLERKRADKLQER 552
KTI L +E + ++ S + + L+ L E++R +K +++
Sbjct: 345 LQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQ 404
Query: 553 LQDILTN--SKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKES 602
L+ ILT K S LEE+ T+ ++ + +++L EKE+
Sbjct: 405 LK-ILTMELQKKSSELEEM----------TKLTNNKEVELEELKKVLGEKET 445
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 99.8 bits (247), Expect = 7e-21
Identities = 146/659 (22%), Positives = 296/659 (44%), Gaps = 128/659 (19%)
Query: 8 EEFQRMQAQLLEL---RTNNYQLSDELRKNGVELTS-LRQKVAYLDKEFSKAQKALSKSK 63
E+FQ Q ++ L R N + + L +L +R+ +A + + SK +++L+ +
Sbjct: 1335 EKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKE 1394
Query: 64 KAQEVEVLLSENE--------MLQAKLHSQEEDFRLQNS-TLMAEFSKERYGKEAGKFSA 114
K E ++SE E +L+ ++ RLQ S M +KE+ + +
Sbjct: 1395 KDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK--DDLQRLQE 1452
Query: 115 VSEGQGDPPGGPAPTVLAPMPLAEVELKWE---MEKEEKRLLWEQLQGLESSKQAETSRL 171
V + + D ++A E ELK ++++E+ + +L+ S K+ E S +
Sbjct: 1453 VLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETI--NELRVNLSEKETEISTI 1510
Query: 172 QEELAKLSEKLKKK-QESFCRLQTEKETLFN-----DSRNKIEELQQRKEADHKAQLART 225
Q++L +++KL+ K QE + EKE FN + + K+ EL+Q KE KA+ +
Sbjct: 1511 QKQLEAINDKLQNKIQEIY-----EKEEQFNIKQISEVQEKVNELKQFKE-HRKAKDSAL 1564
Query: 226 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN--- 282
Q ++ ++ L E +++ Q ++ ++ +Q+ + I+ +E + ++A+
Sbjct: 1565 QSIESKMLELTNRLQESQEEIQ-IMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKES 1623
Query: 283 -------------NALRTSLAALEQIQTA-KTQELNMLREQTTG--LAAELQQQQAEYED 326
N + + +E ++ +TQ+LN+ +T L L + E
Sbjct: 1624 QEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRS 1683
Query: 327 LMGQKDDLNS----------QLQESLRAN-SRLLEQLQEIGQEKEQLTQELQEARKSAEK 375
+ ++DDL S QL+E+LR +R LE+ +E+ + + L+E +++ +K
Sbjct: 1684 VTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEEL----KIVHMHLKEHQETIDK 1739
Query: 376 RKAMLDELAME--TLQEKSQHKEE--------------LGAVRLRHEKEVL----GVRAR 415
+ ++ E E +Q+ +H + + + L+ ++E + G+ +
Sbjct: 1740 LRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSE 1799
Query: 416 YERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERR 475
+L + +D + +L+ +I+E KA +L TL++ V E Q +V M+ K + +
Sbjct: 1800 KTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQ 1859
Query: 476 ----------------------------LKEAEGK---EEELQDVRDQLEQAQEE---RD 501
+KE + EE L+ RDQL+++ +E RD
Sbjct: 1860 SLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARD 1919
Query: 502 CH----LKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDI 556
LKT L +E K+TVD R + + + D+++ L K D+LQ+++Q++
Sbjct: 1920 LEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLD---KSKDELQKKIQEL 1975
Score = 86.7 bits (213), Expect = 6e-17
Identities = 130/582 (22%), Positives = 250/582 (42%), Gaps = 96/582 (16%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLS---DELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
S+EE Q M + E++ L D+L++N E+ + ++ + +F K
Sbjct: 1581 SQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQ 1640
Query: 63 KKAQEVEVLLSENEMLQAKLHSQE-EDFRL-----QNSTLMAEFSKERYGKEAGKFSAVS 116
+K E+E L + E + L + E E+ RL +N M +KER +
Sbjct: 1641 EKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRS------- 1693
Query: 117 EGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELA 176
E LK E ++ ++ L + LE QEEL
Sbjct: 1694 --------------------VEETLKVERDQLKENLRETITRDLEK---------QEELK 1724
Query: 177 KLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAAN 236
+ LK+ QE+ +L+ + ++ N+I +Q+ E + A A+ K+Q+EL A+
Sbjct: 1725 IVHMHLKEHQETIDKLRG----IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAH 1780
Query: 237 QSLAELR---DQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALE 293
L E + D+ +G E L +Q + +A QE+++ L A + L T +
Sbjct: 1781 MHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVN 1840
Query: 294 QIQTAKTQELNMLREQ--------------TTGLAAELQQQQAEYEDLMGQKDDLNSQLQ 339
+ Q K E+ L++Q LA +L + E + +M ++D+L +++
Sbjct: 1841 ETQK-KVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLR-RVE 1898
Query: 340 ESLRAN-SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEEL 398
E+L+ +L E LQE ++ QEL+ AR +++ K +D+L E + EK+ ++
Sbjct: 1899 ETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKL-REKISEKTIQISDI 1957
Query: 399 GAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEEL 458
+K++ + +++++EL + K+ Q ++ + + E+E L++ E
Sbjct: 1958 -------QKDLDKSKDELQKKIQEL-QKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQ 2009
Query: 459 QAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQE----ERDCHLKTISSL---- 510
+ S+ ++L E+ + + RD+L + +E ERD + T+ +
Sbjct: 2010 NLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARD 2069
Query: 511 ------KQEVKDTVDGQR----ILEKKGSAALKDLKRQLHLE 542
K E + DGQ+ L +K S + LKR ++
Sbjct: 2070 RQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMD 2111
Score = 85.1 bits (209), Expect = 2e-16
Identities = 114/557 (20%), Positives = 259/557 (46%), Gaps = 66/557 (11%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK-KA 65
E E R +L E+ + S +L++ +L +++++++ + K+ ++ + ++ K K
Sbjct: 1112 EGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKE 1171
Query: 66 QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGG 125
+E + +E L KL+ E+ + +KER K + E + D G
Sbjct: 1172 LTLEHMETERLELAQKLNENYEEVK--------SITKER--KVLKELQKSFETERDHLRG 1221
Query: 126 PAPTVLAP-------MPLAEVELKWEMEK--EEKRLLWEQLQGLESSKQAETS--RLQEE 174
+ A + +A + LK E E +R + E+ + +++ E S +LQEE
Sbjct: 1222 YIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEE 1281
Query: 175 LAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART--------- 225
+ L E+ QE ++ ET ++ N++E L ++ LAR
Sbjct: 1282 IPVLHEE----QELLPNVKEVSET--QETMNELELLTEQSTTKDSTTLARIEMERLRLNE 1335
Query: 226 --QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSI--QSADAQEQVEGLLAE 281
Q+ Q+E+++ + L+ ++ ++H +++ ++ +S QEQ + +
Sbjct: 1336 KFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEK 1395
Query: 282 NNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQES 341
+N ++ +EQ + K L + + GL+ LQ+ E + + +KDDL +LQE
Sbjct: 1396 DNETTKIVSEMEQFKP-KDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL-QRLQEV 1453
Query: 342 LRANS-RLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGA 400
L++ S +L E ++EI + + +EL+ A ++++ ++EL + S+ + E+
Sbjct: 1454 LQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNL----SEKETEIST 1509
Query: 401 VRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQA 460
+ +K++ + + + +++E++E ++E+ QI E + + EL+ ++ + +
Sbjct: 1510 I----QKQLEAINDKLQNKIQEIYE---KEEQFNIKQISEVQEKVNELKQFKEHRKAKDS 1562
Query: 461 QVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQE----ERDCHLKTISSLKQEVKD 516
+ S++ RL+E++ + + + ++++++ QE ERD LK+ K+
Sbjct: 1563 ALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERD-------QLKENTKE 1615
Query: 517 TVDGQRILEKKGSAALK 533
V + ++K LK
Sbjct: 1616 IVAKMKESQEKEYQFLK 1632
Score = 82.4 bits (202), Expect = 1e-15
Identities = 129/573 (22%), Positives = 248/573 (43%), Gaps = 101/573 (17%)
Query: 18 LELRTNNYQLSDELRKNGVELTSLRQKVAYLDK------EFSKAQKALSKSKKAQEVEVL 71
LEL L EL K E +LR++V L + E + +K + K++E+ ++
Sbjct: 716 LELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQD--KSEELHII 773
Query: 72 LSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGPAPTVL 131
SE + L +++ +E R+Q L+ E K + + + S Q
Sbjct: 774 TSEKDKLFSEVVHKES--RVQG--LLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHM-- 827
Query: 132 APMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCR 191
+ E K++M EE + +++ L Q S L +LS K ++ QE
Sbjct: 828 ------DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTRE 881
Query: 192 LQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAAN---QSLAELRDQRQG 248
+Q E+ + ++E + + + T+KLQQ LE Q +L+ ++
Sbjct: 882 VQ-ERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQES 940
Query: 249 ERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ-----EL 303
++E + D V++ + D QEQ+ NAL + E I T K++
Sbjct: 941 LQIERDQLKSDIHDTVNM-NIDTQEQLR------NALESLKQHQETINTLKSKISEEVSR 993
Query: 304 NMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLT 363
N+ E+ TG + QQ+ D +K DL ++ ++L A+ + EI +++ ++
Sbjct: 994 NLHMEENTGETKDEFQQKMVGID---KKQDLEAKNTQTLTADVKD----NEIIEQQRKIF 1046
Query: 364 QELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELREL 423
+QE K L ++ + EK Q K +L KE + + + ELR L
Sbjct: 1047 SLIQE--------KNELQQMLESVIAEKEQLKTDL--------KENIEMTIENQEELRLL 1090
Query: 424 HEDKKRQEE----ELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEA 479
++ K+Q+E E I++E +R + L + E+L + + ++
Sbjct: 1091 GDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKL--------------KEKSQQL 1136
Query: 480 EGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 539
+ K+++L +V++++ + Q++ + I +LK E+K+ K+L +
Sbjct: 1137 QEKQQQLLNVQEEMSEMQKK----INEIENLKNELKN----------------KELTLE- 1175
Query: 540 HLERKR---ADKLQERLQDILTNSKSRSGLEEL 569
H+E +R A KL E +++ + +K R L+EL
Sbjct: 1176 HMETERLELAQKLNENYEEVKSITKERKVLKEL 1208
Score = 81.3 bits (199), Expect = 3e-15
Identities = 99/461 (21%), Positives = 211/461 (45%), Gaps = 51/461 (11%)
Query: 136 LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 195
+ +++ + E EE L E++ L +E L E+ +L ++++ K E + +E
Sbjct: 722 ITDLQKELNKEVEENEALREEVILL-----SELKSLPSEVERLRKEIQDKSEELHIITSE 776
Query: 196 KETLFNDSRNKIEELQQRKEADHKAQ--LARTQKLQQELEAANQSLAELR-DQRQGERLE 252
K+ LF++ +K +Q E K + LA TQ + + Q+ L D Q ++
Sbjct: 777 KDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKM- 835
Query: 253 HAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTG 312
V ++ +++ L E +SL AL+ + KTQEL +E+T
Sbjct: 836 -----------VLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQEL---QEKTR- 880
Query: 313 LAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKS 372
E+Q++ E E L Q ++ +S LQ R + + E+LQ+ +E + LTQE + ++
Sbjct: 881 ---EVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQL 937
Query: 373 AEKRKAMLDELAME-------TLQEKSQHKEELGAVRLRHEKEVLGVRARYEREL-RELH 424
E + D+L + + + Q + L +++ +H++ + ++++ E+ R LH
Sbjct: 938 QESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLK-QHQETINTLKSKISEEVSRNLH 996
Query: 425 ------EDKKRQEEELRGQIREEKARTRELETLQQTVE-----ELQAQVHSMDGAKGWFE 473
E K ++++ G +++ + +TL V+ E Q ++ S+ K +
Sbjct: 997 MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056
Query: 474 RRLKEAEGKEEELQ-DVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAAL 532
+ L+ ++E+L+ D+++ +E E ++ LK++ + + KK
Sbjct: 1057 QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116
Query: 533 KDLKRQLHLERK---RADKLQERLQDILTNSKSRSGLEELV 570
+ R +E K ++ +LQE+ Q +L + S +++ +
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI 1157
Score = 57.8 bits (138), Expect = 3e-08
Identities = 100/492 (20%), Positives = 197/492 (40%), Gaps = 89/492 (18%)
Query: 162 SSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNK-----IEELQQRKEA 216
++K ++ EL L + +L+TEKE + + K E L+++ +
Sbjct: 487 ATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKK 546
Query: 217 DHKAQL----ARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSA--- 269
D + QL + + L + E NQ L + E ++ LQ+ + Q
Sbjct: 547 DQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENI 606
Query: 270 --DAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDL 327
D +E + + ++ +L E + +E LR + L ++++ Y+ +
Sbjct: 607 KMDLSYSLESI-EDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQM 665
Query: 328 MGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQEL--------------------- 366
SQL+ + L ++LQ E +LT +
Sbjct: 666 ENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDL 725
Query: 367 -QEARKSAEKRKAMLDELAM-----------ETLQEKSQHK-EELGAVRLRHEK---EVL 410
+E K E+ +A+ +E+ + E L+++ Q K EEL + +K EV+
Sbjct: 726 QKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVV 785
Query: 411 GVRARYERELRELHEDK----------KRQEEELRG-------QIREEKARTRELETLQQ 453
+R + L E+ + K K ++E + ++ K E E + Q
Sbjct: 786 HKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQ 845
Query: 454 TVEELQAQVHSMDGAKGWFERRL----KEAEGKEEELQDVRDQLEQAQEE---RDCHLKT 506
+ L + D + G + L +E + K E+Q+ +++EQ +E+ RD L+T
Sbjct: 846 EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQT 905
Query: 507 ISSLK----QEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQD-----IL 557
+ K ++++ T++ + L ++ LK L+ L +ER D+L+ + D I
Sbjct: 906 VEREKTLITEKLQQTLEEVKTLTQE-KDDLKQLQESLQIER---DQLKSDIHDTVNMNID 961
Query: 558 TNSKSRSGLEEL 569
T + R+ LE L
Sbjct: 962 TQEQLRNALESL 973
Score = 42.7 bits (99), Expect = 0.001
Identities = 113/587 (19%), Positives = 233/587 (39%), Gaps = 101/587 (17%)
Query: 1 MAQALSEEEFQ--RMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKA 58
+ + +SE+ Q +Q L + + + EL+K ++L +++ V K+ ++ ++
Sbjct: 1943 LREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQ- 2001
Query: 59 LSKSKKAQEVEV--LLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVS 116
L K +AQ + + + +N L KLH E+ R+ +KER K S
Sbjct: 2002 LKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRI--------VAKERDELRRIKESLKM 2053
Query: 117 EGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELA 176
E + + + + K EKRLL + Q L S + + SR++E L
Sbjct: 2054 ERD--------QFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLK 2105
Query: 177 KLSEKLKKKQESFCRLQT--EKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEA 234
+ SE + E RL EKE F +EL R +A+ +T+ +++ L
Sbjct: 2106 RYSE-MDDHYECLNRLSLDLEKEIEFQ------KELSMRVKANLSLPYLQTKHIEK-LFT 2157
Query: 235 ANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGL----------LAENNA 284
ANQ + +E ++ L+ +S + +EQ E + + +
Sbjct: 2158 ANQRCS----------MEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKE 2207
Query: 285 LRTSLAALEQIQTAKTQELNMLR-EQTTGL----------AAELQQQQAEYEDLMGQKDD 333
L + L+Q ++EL L+ Q L +E + E++ ++ + +
Sbjct: 2208 LLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKE 2267
Query: 334 LNSQLQESLRA-------------------------NSRLLEQLQEIGQEKEQ---LTQE 365
+ L+E L N+R++ + E + +E+ +++E
Sbjct: 2268 MTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKE 2327
Query: 366 LQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARY--ERELREL 423
++ KS +++ L + +TL+ ++ ++ + RA ++REL
Sbjct: 2328 WEQDLKSLKEKNEKLFK-NYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIREL 2386
Query: 424 HEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGK- 482
+E + + +ELE + +LQA+VH + + ++ + K
Sbjct: 2387 ENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKV 2446
Query: 483 -------EEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR 522
+EE++D++ +L + E+ + K K TV+ Q+
Sbjct: 2447 ALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQK 2493
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 99.4 bits (246), Expect = 9e-21
Identities = 138/590 (23%), Positives = 253/590 (42%), Gaps = 50/590 (8%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELR-KNGVELTSLRQKVAY---LDKEFSKAQKALSKS 62
E + +QL E + QL +++ K + L++ K A L AQ AL
Sbjct: 620 ETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD- 678
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
K QE+ + ++ + + AKL ++E S L KE+Y K + EGQ
Sbjct: 679 -KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY--KEKYLSLEQKTEEL-EGQIKK 734
Query: 123 PGGPAPTVLAPMPLAEVELKW--------EMEKEEKRLLWEQLQGLESSKQAETSRLQEE 174
+ V A A +L+ E+ E E + + SS + + + E
Sbjct: 735 LEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA 794
Query: 175 LAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQ----------QRKEADHKAQLAR 224
L + +KL K++E L+ + ETL +++ + EEL Q+ + + +A +
Sbjct: 795 LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTE 854
Query: 225 TQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNA 284
++ +L + SL + + + E + AA+ L+ Q Q+E L E
Sbjct: 855 LSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE 914
Query: 285 LRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRA 344
L+ SL ++ ELN ++EQ L+Q + E + L G ++L ++ +
Sbjct: 915 LKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQ 974
Query: 345 NSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDE--LAMETLQEKSQHK-EELGAV 401
L +L+ +K +L +LQ+ A + A E ++ EKSQ ++L +
Sbjct: 975 IEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSD 1034
Query: 402 RLRHEKEVLGVRARYERELRELHEDKKRQEEEL---RGQIREEKARTRELETLQQTVEEL 458
E E+L R ++L+ + E +E+L R QI + +EL+T + T+E+
Sbjct: 1035 FYGRESELLATR----QDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQD 1090
Query: 459 QAQVHS--MDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKD 516
A+ + K + KE KE+EL + + +L + +E + K I+ L +E+K
Sbjct: 1091 SAKKEQQLQERCKA-LQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELK- 1148
Query: 517 TVDGQRILEKKGSAALKDLKRQLHLERK-----RADKLQERLQDILTNSK 561
++ K LKD K QL +++K +AD L+ ++ N +
Sbjct: 1149 ---SHKLESIKEITNLKDAK-QLLIQQKLELQGKADSLKAAVEQEKRNQQ 1194
Score = 99.0 bits (245), Expect = 1e-20
Identities = 140/622 (22%), Positives = 270/622 (43%), Gaps = 90/622 (14%)
Query: 11 QRMQAQLLELRTNNYQLSDELRKNGV-------ELTSLRQKVAYLDKEFSKAQKALSKSK 63
Q++Q++L T+ +++ EL + G EL+ + K +L EF + Q+ + +
Sbjct: 347 QQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQ--QREE 404
Query: 64 KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPP 123
K Q L SE L +KL E E +G+ + SE D
Sbjct: 405 KEQHGLQLQSEINQLHSKLLETERQLG------------EAHGRLKEQRQLSSEKLMDKE 452
Query: 124 GGPAPTVLAPMPLAE---------VELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEE 174
A L L E EL+ +++K +++ ++ Q L+ S A+ Q +
Sbjct: 453 QQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQ--HQEQQALQQSTTAKLREAQND 510
Query: 175 LAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADH------KAQLARTQKL 228
L ++ ++ K + L E L S+ I L++ +E + + + A +L
Sbjct: 511 LEQVLRQIGDKDQKIQNL----EALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL 566
Query: 229 QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSAD---AQEQVEGLLAENNAL 285
Q++ + + +L ++ + + H A L DQV Q A AQ++V L N L
Sbjct: 567 QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626
Query: 286 RTSLAALEQIQTAKTQELNM-LREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRA 344
+ L ++ K +L++ ++ +T L + + A+ DL D + LQ+
Sbjct: 627 NSQLNESKE----KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK--- 679
Query: 345 NSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLR 404
++L +I + +Q+T +LQ+ ++ + ++ L E + L + + +E G ++ +
Sbjct: 680 ----QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIK-K 734
Query: 405 HEKEVLGVRARYEREL------RELHEDKKRQEEELRGQIREEK---ARTR-----ELET 450
E + L V+A E+ L R+L+ D + + EL Q+ EK + TR + E
Sbjct: 735 LEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEA 794
Query: 451 LQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEEL----QDVRDQLEQAQEERDCHLKT 506
L+ ++L Q K FE +E + + EEL Q +L++ + E++ +
Sbjct: 795 LESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTE 854
Query: 507 ISSLKQEVKDTVDGQRILE-------KKGSAAL-------KDLKRQLHLERKRADKLQER 552
+S++K ++ D + + +KG AA+ K+LK QL ++ + K Q+
Sbjct: 855 LSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKE 914
Query: 553 LQDILTNSKSRSGLEELVLSEM 574
L+ L K S +L L+ M
Sbjct: 915 LKKSLEKEKEASHQLKLELNSM 936
Score = 89.0 bits (219), Expect = 1e-17
Identities = 134/627 (21%), Positives = 270/627 (43%), Gaps = 105/627 (16%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK- 61
QAL + + QR LELR E+ K V T L L K+ + K
Sbjct: 748 QALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLD-----LQKKSEALESIKQKL 802
Query: 62 SKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEA---------GKF 112
+K+ +E ++L + E L + Q E+ + T + E K + KEA K
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862
Query: 113 SAVSEG------QGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQ---GLESS 163
S VS+ + + + + ELK +++ + + L EQ + LE
Sbjct: 863 SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKE 922
Query: 164 KQA------ETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEAD 217
K+A E + +QE+L + LK+ ++ +LQ L S K ++++ +
Sbjct: 923 KEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGEL 982
Query: 218 HKAQLARTQ---KLQQELEAANQSLAELRDQ------------------------RQGER 250
A L +T+ KLQQ+L A Q LA +++ R+ E
Sbjct: 983 KIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESEL 1042
Query: 251 LEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQT 310
L L+++++++S+ D L++ N + +++++TAK L + +
Sbjct: 1043 LATRQDLKSVEEKLSLAQED-------LISNRNQIGNQNKLIQELKTAKAT----LEQDS 1091
Query: 311 TGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIG--QEKE--QLTQEL 366
+LQ++ +D+ +K S ++ L L +++EI QEKE +L +EL
Sbjct: 1092 AKKEQQLQERCKALQDIQKEK----SLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEEL 1147
Query: 367 QEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHED 426
+ + + K L + +Q+K + + + +++ E+E +R + L +
Sbjct: 1148 KSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQE--------KRNQQILKDQ 1199
Query: 427 KKRQEEELRGQIREEKAR----TRELETLQQTVEELQA----QVHSMDGAKGWFERRLKE 478
K++EEEL+ + E++A+ +E E + EE +A Q+ +++ G ++ +
Sbjct: 1200 VKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQS 1259
Query: 479 AEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR-ILEK--KGSAALKDL 535
++ + EL+ D L I+ L+ V++ D +R +LE+ KG ++ L
Sbjct: 1260 SQRRVSELEKQTDDLR----------GEIAVLEATVQNNQDERRALLERCLKGEGEIEKL 1309
Query: 536 KRQLHLERKRADKLQERLQDILTNSKS 562
+ ++ +++ D +Q++ ++S
Sbjct: 1310 QTKVLELQRKLDNTTAAVQELGRENQS 1336
Score = 76.6 bits (187), Expect = 6e-14
Identities = 105/504 (20%), Positives = 225/504 (44%), Gaps = 53/504 (10%)
Query: 145 MEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEK---ETLFN 201
+++++ LL +++Q L++S L+EE SE+LKK+ E + LQ ++ + L
Sbjct: 80 LKRDDVTLLRQEVQDLQAS-------LKEE-KWYSEELKKELEKYQGLQQQEAKPDGLVT 131
Query: 202 DSRNKIEELQQRKEADHKAQLARTQK---LQQELEAANQSLAELRDQRQGERLEHAAA-- 256
DS +++ L+Q+ E Q +Q+ +A+++ + ER AA
Sbjct: 132 DSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQ 191
Query: 257 -LRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLRE---QTTG 312
+ L ++++ ++ Q+ LL ++ E +Q + NM E ++
Sbjct: 192 KVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMD-NMTLERERESEK 250
Query: 313 LAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKS 372
L E ++ Q++Y L S+L + + + +++LQ++ +LTQ+ Q ++
Sbjct: 251 LKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTEN 310
Query: 373 AEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELH------ED 426
K++ +L E E+S K+ + A + + + +++R LH +
Sbjct: 311 LLKKEQDYTKLE-EKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSE 369
Query: 427 KKRQEEELRGQIREEKARTR----ELETLQQTVEE-------LQAQVHSMDGAKGWFERR 475
K ++L+ ++ E + + + E + LQQ EE LQ++++ + ER+
Sbjct: 370 KGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQ 429
Query: 476 LKEAEGKEEELQDVRDQ--LEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALK 533
L EA G+ +E + + + +++ Q+ D LK +S L++++K+ V L+ + +
Sbjct: 430 LGEAHGRLKEQRQLSSEKLMDKEQQVADLQLK-LSRLEEQLKEKVTNSTELQHQLDKTKQ 488
Query: 534 DLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSY 593
+ Q L++ KL+E D+ E VL ++ + + +
Sbjct: 489 QHQEQQALQQSTTAKLREAQNDL-----------EQVLRQIGDKDQKIQNLEALLQKSKE 537
Query: 594 REILREKESSAVPARVRGKEEPTA 617
L EKE + A+++ E TA
Sbjct: 538 NISLLEKEREDLYAKIQAGEGETA 561
Score = 69.3 bits (168), Expect = 1e-11
Identities = 91/412 (22%), Positives = 170/412 (41%), Gaps = 35/412 (8%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDK-------EFSKAQKA 58
+E+E Q++Q + EL+ S E +K +E K+A L K + Q A
Sbjct: 950 NEKEEQQLQGNINELKQ-----SSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAA 1004
Query: 59 LSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEG 118
+ + +++ VL + E Q + DF + S L+A + +E +
Sbjct: 1005 QELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLI 1064
Query: 119 QGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKL 178
G ++ + A+ L+ + K+E++ L E+ + L+ Q E S ++EL
Sbjct: 1065 SNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQ-LQERCKALQDI-QKEKSLKEKELVNE 1122
Query: 179 SEKLKKKQESFCRLQTEKETLFNDSR-NKIEELQQRKEADHKAQLARTQKLQQELEAANQ 237
KL + +E CR + E L + + +K+E +++ QL QKL EL+
Sbjct: 1123 KSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKL--ELQGKAD 1180
Query: 238 SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQ----EQVEGLLAENNALRTSLAALE 293
SL +Q + + + L+DQV + + + E+ L +E + E
Sbjct: 1181 SLKAAVEQEKRNQ-------QILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHE 1233
Query: 294 QIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQL-------QESLRANS 346
+ + T ++ L E + E Q Q +L Q DDL ++ Q +
Sbjct: 1234 ENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERR 1293
Query: 347 RLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEEL 398
LLE+ + E E+L ++ E ++ + A + EL E + +H + L
Sbjct: 1294 ALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQAL 1345
Score = 33.5 bits (75), Expect = 0.60
Identities = 55/253 (21%), Positives = 97/253 (38%), Gaps = 28/253 (11%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTS-----LRQKVAYLDKEFSKAQK 57
++L E+E +++L E+ + E+ K EL S +++ D + Q+
Sbjct: 1112 KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ 1171
Query: 58 ALSKSKKAQEVEVLLSENEMLQAKLHSQ---EEDFRLQNSTLMAEFSKERYGKEAGKFSA 114
L KA ++ + + + Q L Q EE+ E KE KEA S
Sbjct: 1172 KLELQGKADSLKAAVEQEKRNQQILKDQVKKEEE----------ELKKEFIEKEAKLHSE 1221
Query: 115 VSE---GQGDPPGGPAPTVLAPMPLAE----VELKWEMEKEEKRLLWEQ---LQGLESSK 164
+ E G A + L E V+ +W+ + L +Q L+G +
Sbjct: 1222 IKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVL 1281
Query: 165 QAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLAR 224
+A Q+E L E+ K + +LQT+ L N +Q+ + Q+
Sbjct: 1282 EATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKH 1341
Query: 225 TQKLQQELEAANQ 237
TQ L ++ N+
Sbjct: 1342 TQALNRKWAEDNE 1354
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 99.4 bits (246), Expect = 9e-21
Identities = 131/550 (23%), Positives = 237/550 (43%), Gaps = 78/550 (14%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
L EEE R+Q + +L EL K E+ L A ++E ++ KSK+
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRSTSEKSKQ 1787
Query: 65 AQEVEV-LLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE---AGKFSAVSEGQG 120
E E E A+L + E+ + Q + +++R E A K +A+ E
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA-- 1845
Query: 121 DPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE 180
++ + E+ +EK E+L+ L + + RL+E+ A+
Sbjct: 1846 ----------------TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 181 KLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQQEL 232
+ +E +L+ ++ + +E+ L+QR++ + + + A K + EL
Sbjct: 1890 DI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946
Query: 233 EAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNALRTS 288
E +S AE LR + Q E AA R L + + +A+E+V+ L AE A R
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2004
Query: 289 LAALEQIQ--TAKTQELNMLREQTTGLAAELQQ--QQAEYEDLMGQK-------DDLNSQ 337
AALE+++ AK +E LRE+ +A Q Q+A + L ++ +
Sbjct: 2005 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2064
Query: 338 LQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEE 397
LQ++L+ +L+QL+ + + +E +EAR AE+ E Q + Q +E
Sbjct: 2065 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----------EAAQSRRQVEE- 2113
Query: 398 LGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEE 457
A RL+ E E + + E+LR + +E AR + E Q + +
Sbjct: 2114 --AERLKQSAE----------EQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQ 2159
Query: 458 LQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDT 517
QA M+ K + E+ L++ E+EL +R QLE+ +++ + + LK E +
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219
Query: 518 VDGQRILEKK 527
+ +E++
Sbjct: 2220 ARQRSQVEEE 2229
Score = 94.0 bits (232), Expect = 4e-19
Identities = 140/621 (22%), Positives = 252/621 (40%), Gaps = 43/621 (6%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA 65
+E E Q ++A+ E Q +E + LR++V + +A+ L+ KA
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAER-------LRRQVQDESQRKRQAEVELASRVKA 1523
Query: 66 QEVEVLLSENEMLQA----KLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGD 121
E E + LQA +L ++E + RL+ + + + + E + SA +E Q
Sbjct: 1524 -EAEAAREKQRALQALEELRLQAEEAERRLRQAEV-ERARQVQVALETAQRSAEAELQSK 1581
Query: 122 PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 181
T L E + +EE +Q QAE R +EE + E+
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELER 1633
Query: 182 LKKKQESFCRLQTEKETLFND-SRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLA 240
+ K RL+ + E + S + E +Q++EA+ +A R + +E + LA
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA---RRRGKAEEQAVRQRELA 1690
Query: 241 ELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT 300
E ++Q + E A R +Q I+ EQ E + L LA L++ A T
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREAAAAT 1747
Query: 301 QELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE 360
Q+ L + + AE++ A + + + ++ L A + +L E
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 361 QLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE- 419
L +E + R+ AE+ A A L EK E A RL+ E E+ E E
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENER 1865
Query: 420 LRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEA 479
LR L ED+ Q L Q + KA E + + +A ++ KG E L++
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEE-----RLAQLRKASDSELERQKGLVEDTLRQR 1920
Query: 480 EGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 539
EEE+ ++ E+A + + ++ +DT+ + E + + +RQL
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-----QRQL 1975
Query: 540 HL-ERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 598
E +R + +ER+Q L + + + L E+ + + ++ + + +E R
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRLRERAEQESAR 2034
Query: 599 EKESSAVPARVRGKEEPTAPA 619
+ + + A+ R + E A A
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHA 2055
Score = 94.0 bits (232), Expect = 4e-19
Identities = 134/579 (23%), Positives = 249/579 (43%), Gaps = 58/579 (10%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
+A E+E ++ QL E L +EL++ E T ++ + +++E
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-------- 2232
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
V V + E L+A++ ++ L++ F +E EA K V+E +
Sbjct: 2233 -----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE----EAEKMKQVAE-EAAR 2282
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
A LAE +L + EK +L E++Q ++ E +RL+ E L ++
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQK 2336
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAE 241
+ QE RLQ +KE + + + Q+ EA+ + QL + + ++ +L A S A+
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + +R A + +++ QE+V T + LE +
Sbjct: 2397 ARAEEDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDH 2443
Query: 302 ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQ 361
+ LRE L E ++ Q E + L + +++ + QE L ++ L+Q EK+
Sbjct: 2444 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--SFLSEKDS 2501
Query: 362 LTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELR 421
L Q + E+ KA L++L + + + Q +EE + + E+E + A E R
Sbjct: 2502 LLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 422 ELHEDK---KRQEEELRGQIREEKARTREL--ETLQQTVEELQAQVHSMDGAKGWFERRL 476
HE + +R++EEL+ Q+ +++ + EL E Q+ E+LQ A E
Sbjct: 2558 RQHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616
Query: 477 KEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK 536
+ L + RD L+ E + + L+++ V QR L++ G + ++L+
Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VSAQR-LQEAGILSAEELQ 2670
Query: 537 RQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 575
R L D+L R +D+ + RS + L+L N
Sbjct: 2671 R-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2707
Score = 92.0 bits (227), Expect = 1e-18
Identities = 117/505 (23%), Positives = 213/505 (42%), Gaps = 43/505 (8%)
Query: 1 MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
+ Q+ E+ R QAQ + + R+ E +LRQK A D E K +K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2175
Query: 61 KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQG 120
++ + Q+ +V E E+ +L +E D + + K + A + S V E
Sbjct: 2176 QTLR-QKAQV---EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--- 2228
Query: 121 DPPGGPAPTVLAPMPLAEV-ELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLS 179
+ + E+ +LK +E E + L+ + Q E ++++ + +
Sbjct: 2229 -------ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281
Query: 180 EKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQ--LARTQKLQQELEAANQ 237
QE+ Q +E L + L+++ +A +A A + LQQ+ E A +
Sbjct: 2282 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2341
Query: 238 SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQT 297
L++ ++ + A + Q + A+ Q Q+E + AE L+ +A + + Q
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTL---EAERQRQLE-MSAEAERLKLRVAEMSRAQA 2397
Query: 298 AKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ 357
++ R+Q + +L + + ++ + L Q Q+S RL E + E+ +
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457
Query: 358 EKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYE 417
EKE+L QE + + +E+ + + E ++ Q Q EK+ L R R+
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--------SFLSEKDSLLQRERFI 2509
Query: 418 RELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
+ + E + E Q+REE+ R + QQ +E Q V SM+ A+ RR
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQ-----QQMEQERQRLVASMEEAR----RRQH 2560
Query: 478 EAE----GKEEELQDVRDQLEQAQE 498
EAE K+EELQ + Q Q +E
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEE 2585
Score = 88.6 bits (218), Expect = 2e-17
Identities = 107/465 (23%), Positives = 194/465 (41%), Gaps = 69/465 (14%)
Query: 136 LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 195
LAEVE E +++ + E + R+QEE+ + E Q+ +Q E
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1421
Query: 196 KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 255
+ L S +I+ ++ EA +++L ++++E+ L QR G E
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1476
Query: 256 ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 293
ALRA ++ Q AQE+ E L AE A R AL+
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 294 QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 342
++ + Q E+ R+ L + +AE + + +QL+ SL
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 343 RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 402
+ + QL+E + + Q E + AR+ AE+ +E Q K+ A+R
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1643
Query: 403 LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQV 462
LR + E + + + E +++ +E RG+ E+ R REL +Q +E+ Q Q+
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL--AEQELEK-QRQL 1700
Query: 463 HSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR 522
A+G ++RL E+EL +R + EQ +++R + ++ L++E ++
Sbjct: 1701 -----AEGTAQQRL----AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 523 ILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE 567
LE + + K + +E A K + + T+ KS+ LE
Sbjct: 1752 ELEAELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1790
Score = 87.8 bits (216), Expect = 3e-17
Identities = 163/704 (23%), Positives = 291/704 (41%), Gaps = 154/704 (21%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
+E+E R++A+ + L +EL + E + QK L+ E +K A+ + +
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 64 KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKER-YGKEAGKFSAVSEGQGDP 122
KA+ E S +E + +L ++ FR L E ++ R +EA + ++E
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1826
Query: 123 PGGPAPTVLAPMPLAEVE---LKWEME--KEEKRLLWEQLQGLESSKQAETSRLQEELAK 177
A VLA A E LK E E +EK E+L+ L + + RL+E+ A+
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1886
Query: 178 LSEKLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQ 229
+ +E +L+ ++ + +E+ L+QR++ + + + A K +
Sbjct: 1887 HKADI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 230 QELEAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNAL 285
ELE +S AE LR + Q E AA R L + + +A+E+V+ L AE A
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 286 RTSLAALEQIQT--AKTQELNMLREQTTGLAAE--------------------------- 316
R AALE+++ AK +E LRE+ +A
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 317 -------LQQQQAEYEDLMGQKDDLNSQLQESLRA----------NSRLLEQLQEIGQEK 359
LQQ+Q+ + L G+ + +E+ A + R +E+ + + Q
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 360 EQLTQELQEARKSAEK----------RKAMLDELAM------------------ETLQEK 391
E+ Q +A+ +AEK R+A ++ A+ +TL++K
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 392 SQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL-------RELH 424
+Q ++EL +RL+ H+K +L R++ E EL EL
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 425 EDKKRQEEELRGQIREEKARTR-----ELETLQQTVEEL--------------QAQVHSM 465
+ K R E E R I +K T+ E E ++Q EE Q +
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301
Query: 466 DGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE 525
+ E+ LKE +E ++ + E Q++++ + L QE K+ + Q E
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL-QEDKEQMAQQLAEE 2360
Query: 526 KKGSAALKDLKRQLHLERK-RADKLQERLQDILTNSKSRSGLEE 568
+G + +RQ LE A++L+ R+ ++ S++++ EE
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEM---SRAQARAEE 2401
Score = 82.0 bits (201), Expect = 1e-15
Identities = 115/491 (23%), Positives = 210/491 (42%), Gaps = 59/491 (12%)
Query: 166 AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 225
+ET R EE +L+E+ + ++ RL E E R E Q K +
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394
Query: 226 QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 282
Q++Q+E+ ++ + + Q++ E L+ + Q + A+A E+ + E
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 283 NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 341
+R L A E+ + EL LR + A+ +Q Q E E L Q +D+ + Q
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 342 LRANSRLLEQLQEIGQEKEQLTQELQEAR----------KSAEKRKAMLDELAMETLQ-- 389
+ SR+ + E +EK++ Q L+E R + AE +A ++A+ET Q
Sbjct: 1515 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 390 -------------------EKSQHKEELGAVRLRHEKE------VLGVRARYERELRELH 424
E+S +E + +LR E E RAR E E REL
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELE 1632
Query: 425 EDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKE 483
+ + E LR +++ EE A+ + L + ++ +A+ + K E+ +++ E E
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQRELAE 1691
Query: 484 EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLER 543
+EL+ R E ++R + + L+ E + +++LE ++L R L+R
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-------EELAR---LQR 1741
Query: 544 KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 603
+ A Q+R + +K R+ +E L+ S+ + +++ S E R +E +
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE-AEAGRFRELA 1800
Query: 604 AVPARVRGKEE 614
AR+R E
Sbjct: 1801 EEAARLRALAE 1811
Score = 81.6 bits (200), Expect = 2e-15
Identities = 153/612 (25%), Positives = 241/612 (39%), Gaps = 98/612 (16%)
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
K+AQ V L E E +A L Q T A + R +E G+ G+ D
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD- 1171
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
EVE +W +E L E+ Q + A+T Q EL +L +L
Sbjct: 1172 --------------VEVE-RW---RERVAQLLERWQAV----LAQTDVRQRELEQLGRQL 1209
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKA---QLARTQKLQQELEAANQSL 239
+ +ES L D+R + E++Q AD +A QL + Q L +E+E
Sbjct: 1210 RYYRESADPLGA----WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE------ 1259
Query: 240 AELRDQRQGERLEHAAA-----LRALQD-QVSIQSADAQ-EQVEGLLAENNALRTSLAAL 292
R GE++E + A++D ++ + + AQ E V + S + +
Sbjct: 1260 ------RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313
Query: 293 EQIQTAKTQ--ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLE 350
++ +T EL L Q +E ++ E E L Q+ + + A
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1373
Query: 351 QLQEI-GQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEV 409
QL E Q K Q +E +E ++ ++ +E A++ Q+K +EEL +R E E+
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433
Query: 410 LG----------VRARYERELRELH---EDKKRQEEELRGQIREEKARTRELET----LQ 452
R R E E+R + E +RQ G+++ +AR E E Q
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1493
Query: 453 QTVEELQAQVHSMDGAKGWFERRL-----KEAEGKEEE------LQDVRDQLEQAQEERD 501
+ E L+ QV K E L EAE E+ L+++R Q E+A ER
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERR 1551
Query: 502 CHLKTISSLKQEVKDTVDGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE--- 551
+ +Q QR E K+ S A K L+R L E +L+E
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1611
Query: 552 -RLQDILTNSKSRSGLE-ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAV 605
R Q ++R E EL ++ + R Q + + S + E ++KE +
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 606 PARVRGKEEPTA 617
AR RGK E A
Sbjct: 1672 EARRRGKAEEQA 1683
Score = 65.5 bits (158), Expect = 1e-10
Identities = 91/442 (20%), Positives = 182/442 (41%), Gaps = 62/442 (14%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKA-----QK 57
QA+ E + +A+LL+ + Q ++ R+ + + Q++A + F + Q+
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Query: 58 ALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSE 117
L S +A+ +++ ++E QA+ + FR Q + + + + K + V
Sbjct: 2375 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQT 2433
Query: 118 GQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQE 173
+ +AE+E + E ++E +LL + + +++ +Q ET LQ+
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 174 ELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELE 233
+ L +++ + + + E LF D K ++L++ + Q+ QQ++E
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQME 2542
Query: 234 AANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALE 293
Q L ++ + + E +R Q+++ ++Q E L EN LR L LE
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Query: 294 Q--------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ 339
+ Q A T+ L R+ G AAE + + + D L ++
Sbjct: 2603 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS 2654
Query: 340 ESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEEL 398
++LQE G + Q L + + +DELA E ++ Q + +
Sbjct: 2655 ---------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSI 2698
Query: 399 GAVRLRHEKEVLGVRARYEREL 420
+ L+ E L V A +R+L
Sbjct: 2699 AGLLLKATNEKLSVYAALQRQL 2720
Score = 40.0 bits (92), Expect = 0.006
Identities = 87/388 (22%), Positives = 155/388 (39%), Gaps = 40/388 (10%)
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQ-SLAE 241
++ QE+ RL+ + + L L + D K+ LA Q L+++++ SLA
Sbjct: 863 QEAQEAVTRLEAQHQALVT--------LWHQLHVDMKSLLA-WQSLRRDVQLIRSWSLAT 913
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + E+ + AL +L+ D+Q+ A L A + +
Sbjct: 914 FRTLKPEEQRQ---ALHSLELHYQAFLRDSQD------AGGFGPEDRLMAEREYGSCSHH 964
Query: 302 ELNMLREQTTGLAAELQQQQ--AEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEK 359
+L+ G E + Q+ +E +D+ Q + ++ LR L +E +E
Sbjct: 965 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR-----LPLDKEPAREC 1019
Query: 360 EQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE 419
Q E Q+A+ E + L+ E + + + A LR E E+ + R
Sbjct: 1020 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1079
Query: 420 LRELHEDK-KRQEEELRG-QIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
L ++ +K K +RG Q EE R E E L++ + + A + ++ K ++
Sbjct: 1080 LSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEA-QAVPATLPELEATKASLKKLRA 1137
Query: 478 EAEGKEEELQDVRDQLEQAQE----------ERDCHLKTISSLKQEVKDTVDGQRILEKK 527
+AE ++ +RD+L AQE ERD ++ ++ +
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1197
Query: 528 GSAALKDLKRQLHLERKRADKLQERLQD 555
L+ L RQL R+ AD L LQD
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQD 1225
Score = 38.9 bits (89), Expect = 0.014
Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)
Query: 133 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 189
P EVE + RLL+ +Q L+ + + ++ + +L E+L + +
Sbjct: 432 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 491
Query: 190 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 225
R + E TL D +EE Q R + A+ L
Sbjct: 492 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 551
Query: 226 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 285
+ +QS+ E R + + R + A + Q LL + A
Sbjct: 552 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 611
Query: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 345
SL +L A T+EL L E+ E+ ++ M K + S L L
Sbjct: 612 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 668
Query: 346 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 405
+ +++LQ G ++L +E AR + E +A LQ + +L H
Sbjct: 669 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 717
Query: 406 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 464
KE ++ ++RE ++ +E LR + + A LE L Q ++ + Q++
Sbjct: 718 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 776
Query: 465 MDGAKGWFERRLK 477
G +R K
Sbjct: 777 YKGHLSGLAKRAK 789
Score = 35.0 bits (79), Expect = 0.21
Identities = 50/233 (21%), Positives = 104/233 (44%), Gaps = 26/233 (11%)
Query: 165 QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 223
+A+ R + + +LS + ++ RL + L N S+ ++ L E+ H A
Sbjct: 569 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 624
Query: 224 RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 279
T++L ++E E ++ ++ ++A +R L+ + + + Q + LL
Sbjct: 625 ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 683
Query: 280 AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 336
E++ R ++ E Q A + + + + + A L++ A ++ D+ + L
Sbjct: 684 REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 739
Query: 337 QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML 380
+LQE+LR +RL + LQ+ EKEQL + A++ KA++
Sbjct: 740 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 792
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 99.4 bits (246), Expect = 9e-21
Identities = 131/550 (23%), Positives = 237/550 (43%), Gaps = 78/550 (14%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
L EEE R+Q + +L EL K E+ L A ++E ++ KSK+
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRSTSEKSKQ 1791
Query: 65 AQEVEV-LLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE---AGKFSAVSEGQG 120
E E E A+L + E+ + Q + +++R E A K +A+ E
Sbjct: 1792 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA-- 1849
Query: 121 DPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE 180
++ + E+ +EK E+L+ L + + RL+E+ A+
Sbjct: 1850 ----------------TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1893
Query: 181 KLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQQEL 232
+ +E +L+ ++ + +E+ L+QR++ + + + A K + EL
Sbjct: 1894 DI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1950
Query: 233 EAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNALRTS 288
E +S AE LR + Q E AA R L + + +A+E+V+ L AE A R
Sbjct: 1951 ELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2008
Query: 289 LAALEQIQ--TAKTQELNMLREQTTGLAAELQQ--QQAEYEDLMGQK-------DDLNSQ 337
AALE+++ AK +E LRE+ +A Q Q+A + L ++ +
Sbjct: 2009 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2068
Query: 338 LQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEE 397
LQ++L+ +L+QL+ + + +E +EAR AE+ E Q + Q +E
Sbjct: 2069 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----------EAAQSRRQVEE- 2117
Query: 398 LGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEE 457
A RL+ E E + + E+LR + +E AR + E Q + +
Sbjct: 2118 --AERLKQSAE----------EQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQ 2163
Query: 458 LQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDT 517
QA M+ K + E+ L++ E+EL +R QLE+ +++ + + LK E +
Sbjct: 2164 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2223
Query: 518 VDGQRILEKK 527
+ +E++
Sbjct: 2224 ARQRSQVEEE 2233
Score = 94.0 bits (232), Expect = 4e-19
Identities = 140/621 (22%), Positives = 252/621 (40%), Gaps = 43/621 (6%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA 65
+E E Q ++A+ E Q +E + LR++V + +A+ L+ KA
Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAER-------LRRQVQDESQRKRQAEVELASRVKA 1527
Query: 66 QEVEVLLSENEMLQA----KLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGD 121
E E + LQA +L ++E + RL+ + + + + E + SA +E Q
Sbjct: 1528 -EAEAAREKQRALQALEELRLQAEEAERRLRQAEV-ERARQVQVALETAQRSAEAELQSK 1585
Query: 122 PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 181
T L E + +EE +Q QAE R +EE + E+
Sbjct: 1586 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELER 1637
Query: 182 LKKKQESFCRLQTEKETLFND-SRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLA 240
+ K RL+ + E + S + E +Q++EA+ +A R + +E + LA
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA---RRRGKAEEQAVRQRELA 1694
Query: 241 ELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT 300
E ++Q + E A R +Q I+ EQ E + L LA L++ A T
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREAAAAT 1751
Query: 301 QELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE 360
Q+ L + + AE++ A + + + ++ L A + +L E
Sbjct: 1752 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1811
Query: 361 QLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE- 419
L +E + R+ AE+ A A L EK E A RL+ E E+ E E
Sbjct: 1812 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENER 1869
Query: 420 LRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEA 479
LR L ED+ Q L Q + KA E + + +A ++ KG E L++
Sbjct: 1870 LRRLAEDEAFQRRRLEEQAAQHKADIEE-----RLAQLRKASDSELERQKGLVEDTLRQR 1924
Query: 480 EGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 539
EEE+ ++ E+A + + ++ +DT+ + E + + +RQL
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-----QRQL 1979
Query: 540 HL-ERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 598
E +R + +ER+Q L + + + L E+ + + ++ + + +E R
Sbjct: 1980 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRLRERAEQESAR 2038
Query: 599 EKESSAVPARVRGKEEPTAPA 619
+ + + A+ R + E A A
Sbjct: 2039 QLQLAQEAAQKRLQAEEKAHA 2059
Score = 94.0 bits (232), Expect = 4e-19
Identities = 134/579 (23%), Positives = 249/579 (43%), Gaps = 58/579 (10%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
+A E+E ++ QL E L +EL++ E T ++ + +++E
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-------- 2236
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
V V + E L+A++ ++ L++ F +E EA K V+E +
Sbjct: 2237 -----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE----EAEKMKQVAE-EAAR 2286
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
A LAE +L + EK +L E++Q ++ E +RL+ E L ++
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQK 2340
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAE 241
+ QE RLQ +KE + + + Q+ EA+ + QL + + ++ +L A S A+
Sbjct: 2341 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + +R A + +++ QE+V T + LE +
Sbjct: 2401 ARAEEDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDH 2447
Query: 302 ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQ 361
+ LRE L E ++ Q E + L + +++ + QE L ++ L+Q EK+
Sbjct: 2448 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--SFLSEKDS 2505
Query: 362 LTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELR 421
L Q + E+ KA L++L + + + Q +EE + + E+E + A E R
Sbjct: 2506 LLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2561
Query: 422 ELHEDK---KRQEEELRGQIREEKARTREL--ETLQQTVEELQAQVHSMDGAKGWFERRL 476
HE + +R++EEL+ Q+ +++ + EL E Q+ E+LQ A E
Sbjct: 2562 RQHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2620
Query: 477 KEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK 536
+ L + RD L+ E + + L+++ V QR L++ G + ++L+
Sbjct: 2621 ASQVAATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VSAQR-LQEAGILSAEELQ 2674
Query: 537 RQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 575
R L D+L R +D+ + RS + L+L N
Sbjct: 2675 R-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2711
Score = 92.0 bits (227), Expect = 1e-18
Identities = 117/505 (23%), Positives = 213/505 (42%), Gaps = 43/505 (8%)
Query: 1 MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
+ Q+ E+ R QAQ + + R+ E +LRQK A D E K +K
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2179
Query: 61 KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQG 120
++ + Q+ +V E E+ +L +E D + + K + A + S V E
Sbjct: 2180 QTLR-QKAQV---EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--- 2232
Query: 121 DPPGGPAPTVLAPMPLAEV-ELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLS 179
+ + E+ +LK +E E + L+ + Q E ++++ + +
Sbjct: 2233 -------ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2285
Query: 180 EKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQ--LARTQKLQQELEAANQ 237
QE+ Q +E L + L+++ +A +A A + LQQ+ E A +
Sbjct: 2286 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2345
Query: 238 SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQT 297
L++ ++ + A + Q + A+ Q Q+E + AE L+ +A + + Q
Sbjct: 2346 QARRLQEDKEQMAQQLAEETQGFQRTL---EAERQRQLE-MSAEAERLKLRVAEMSRAQA 2401
Query: 298 AKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ 357
++ R+Q + +L + + ++ + L Q Q+S RL E + E+ +
Sbjct: 2402 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2461
Query: 358 EKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYE 417
EKE+L QE + + +E+ + + E ++ Q Q EK+ L R R+
Sbjct: 2462 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--------SFLSEKDSLLQRERFI 2513
Query: 418 RELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
+ + E + E Q+REE+ R + QQ +E Q V SM+ A+ RR
Sbjct: 2514 EQEKAKLEQLFQDEVAKAQQLREEQQRQQ-----QQMEQERQRLVASMEEAR----RRQH 2564
Query: 478 EAE----GKEEELQDVRDQLEQAQE 498
EAE K+EELQ + Q Q +E
Sbjct: 2565 EAEEGVRRKQEELQQLEQQRRQQEE 2589
Score = 88.6 bits (218), Expect = 2e-17
Identities = 107/465 (23%), Positives = 194/465 (41%), Gaps = 69/465 (14%)
Query: 136 LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 195
LAEVE E +++ + E + R+QEE+ + E Q+ +Q E
Sbjct: 1366 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1425
Query: 196 KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 255
+ L S +I+ ++ EA +++L ++++E+ L QR G E
Sbjct: 1426 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1480
Query: 256 ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 293
ALRA ++ Q AQE+ E L AE A R AL+
Sbjct: 1481 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540
Query: 294 QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 342
++ + Q E+ R+ L + +AE + + +QL+ SL
Sbjct: 1541 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1600
Query: 343 RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 402
+ + QL+E + + Q E + AR+ AE+ +E Q K+ A+R
Sbjct: 1601 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1647
Query: 403 LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQV 462
LR + E + + + E +++ +E RG+ E+ R REL +Q +E+ Q Q+
Sbjct: 1648 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL--AEQELEK-QRQL 1704
Query: 463 HSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR 522
A+G ++RL E+EL +R + EQ +++R + ++ L++E ++
Sbjct: 1705 -----AEGTAQQRL----AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1755
Query: 523 ILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE 567
LE + + K + +E A K + + T+ KS+ LE
Sbjct: 1756 ELEAELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1794
Score = 87.8 bits (216), Expect = 3e-17
Identities = 163/704 (23%), Positives = 291/704 (41%), Gaps = 154/704 (21%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
+E+E R++A+ + L +EL + E + QK L+ E +K A+ + +
Sbjct: 1715 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1774
Query: 64 KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKER-YGKEAGKFSAVSEGQGDP 122
KA+ E S +E + +L ++ FR L E ++ R +EA + ++E
Sbjct: 1775 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1830
Query: 123 PGGPAPTVLAPMPLAEVE---LKWEME--KEEKRLLWEQLQGLESSKQAETSRLQEELAK 177
A VLA A E LK E E +EK E+L+ L + + RL+E+ A+
Sbjct: 1831 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1890
Query: 178 LSEKLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQ 229
+ +E +L+ ++ + +E+ L+QR++ + + + A K +
Sbjct: 1891 HKADI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1947
Query: 230 QELEAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNAL 285
ELE +S AE LR + Q E AA R L + + +A+E+V+ L AE A
Sbjct: 1948 LELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2005
Query: 286 RTSLAALEQIQT--AKTQELNMLREQTTGLAAE--------------------------- 316
R AALE+++ AK +E LRE+ +A
Sbjct: 2006 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065
Query: 317 -------LQQQQAEYEDLMGQKDDLNSQLQESLRA----------NSRLLEQLQEIGQEK 359
LQQ+Q+ + L G+ + +E+ A + R +E+ + + Q
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2125
Query: 360 EQLTQELQEARKSAEK----------RKAMLDELAM------------------ETLQEK 391
E+ Q +A+ +AEK R+A ++ A+ +TL++K
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2185
Query: 392 SQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL-------RELH 424
+Q ++EL +RL+ H+K +L R++ E EL EL
Sbjct: 2186 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2245
Query: 425 EDKKRQEEELRGQIREEKARTR-----ELETLQQTVEEL--------------QAQVHSM 465
+ K R E E R I +K T+ E E ++Q EE Q +
Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2305
Query: 466 DGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE 525
+ E+ LKE +E ++ + E Q++++ + L QE K+ + Q E
Sbjct: 2306 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL-QEDKEQMAQQLAEE 2364
Query: 526 KKGSAALKDLKRQLHLERK-RADKLQERLQDILTNSKSRSGLEE 568
+G + +RQ LE A++L+ R+ ++ S++++ EE
Sbjct: 2365 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEM---SRAQARAEE 2405
Score = 82.0 bits (201), Expect = 1e-15
Identities = 115/491 (23%), Positives = 210/491 (42%), Gaps = 59/491 (12%)
Query: 166 AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 225
+ET R EE +L+E+ + ++ RL E E R E Q K +
Sbjct: 1342 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1398
Query: 226 QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 282
Q++Q+E+ ++ + + Q++ E L+ + Q + A+A E+ + E
Sbjct: 1399 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1458
Query: 283 NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 341
+R L A E+ + EL LR + A+ +Q Q E E L Q +D+ + Q
Sbjct: 1459 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1518
Query: 342 LRANSRLLEQLQEIGQEKEQLTQELQEAR----------KSAEKRKAMLDELAMETLQ-- 389
+ SR+ + E +EK++ Q L+E R + AE +A ++A+ET Q
Sbjct: 1519 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1577
Query: 390 -------------------EKSQHKEELGAVRLRHEKE------VLGVRARYERELRELH 424
E+S +E + +LR E E RAR E E REL
Sbjct: 1578 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELE 1636
Query: 425 EDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKE 483
+ + E LR +++ EE A+ + L + ++ +A+ + K E+ +++ E E
Sbjct: 1637 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQRELAE 1695
Query: 484 EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLER 543
+EL+ R E ++R + + L+ E + +++LE ++L R L+R
Sbjct: 1696 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-------EELAR---LQR 1745
Query: 544 KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 603
+ A Q+R + +K R+ +E L+ S+ + +++ S E R +E +
Sbjct: 1746 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE-AEAGRFRELA 1804
Query: 604 AVPARVRGKEE 614
AR+R E
Sbjct: 1805 EEAARLRALAE 1815
Score = 81.6 bits (200), Expect = 2e-15
Identities = 153/612 (25%), Positives = 241/612 (39%), Gaps = 98/612 (16%)
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
K+AQ V L E E +A L Q T A + R +E G+ G+ D
Sbjct: 1117 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD- 1175
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
EVE +W +E L E+ Q + A+T Q EL +L +L
Sbjct: 1176 --------------VEVE-RW---RERVAQLLERWQAV----LAQTDVRQRELEQLGRQL 1213
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKA---QLARTQKLQQELEAANQSL 239
+ +ES L D+R + E++Q AD +A QL + Q L +E+E
Sbjct: 1214 RYYRESADPLGA----WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE------ 1263
Query: 240 AELRDQRQGERLEHAAA-----LRALQD-QVSIQSADAQ-EQVEGLLAENNALRTSLAAL 292
R GE++E + A++D ++ + + AQ E V + S + +
Sbjct: 1264 ------RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1317
Query: 293 EQIQTAKTQ--ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLE 350
++ +T EL L Q +E ++ E E L Q+ + + A
Sbjct: 1318 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1377
Query: 351 QLQEI-GQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEV 409
QL E Q K Q +E +E ++ ++ +E A++ Q+K +EEL +R E E+
Sbjct: 1378 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1437
Query: 410 LG----------VRARYERELRELH---EDKKRQEEELRGQIREEKARTRELET----LQ 452
R R E E+R + E +RQ G+++ +AR E E Q
Sbjct: 1438 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1497
Query: 453 QTVEELQAQVHSMDGAKGWFERRL-----KEAEGKEEE------LQDVRDQLEQAQEERD 501
+ E L+ QV K E L EAE E+ L+++R Q E+A ER
Sbjct: 1498 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERR 1555
Query: 502 CHLKTISSLKQEVKDTVDGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE--- 551
+ +Q QR E K+ S A K L+R L E +L+E
Sbjct: 1556 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1615
Query: 552 -RLQDILTNSKSRSGLE-ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAV 605
R Q ++R E EL ++ + R Q + + S + E ++KE +
Sbjct: 1616 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1675
Query: 606 PARVRGKEEPTA 617
AR RGK E A
Sbjct: 1676 EARRRGKAEEQA 1687
Score = 65.5 bits (158), Expect = 1e-10
Identities = 91/442 (20%), Positives = 182/442 (41%), Gaps = 62/442 (14%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKA-----QK 57
QA+ E + +A+LL+ + Q ++ R+ + + Q++A + F + Q+
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2378
Query: 58 ALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSE 117
L S +A+ +++ ++E QA+ + FR Q + + + + K + V
Sbjct: 2379 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQT 2437
Query: 118 GQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQE 173
+ +AE+E + E ++E +LL + + +++ +Q ET LQ+
Sbjct: 2438 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2497
Query: 174 ELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELE 233
+ L +++ + + + E LF D K ++L++ + Q+ QQ++E
Sbjct: 2498 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQME 2546
Query: 234 AANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALE 293
Q L ++ + + E +R Q+++ ++Q E L EN LR L LE
Sbjct: 2547 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2606
Query: 294 Q--------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ 339
+ Q A T+ L R+ G AAE + + + D L ++
Sbjct: 2607 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS 2658
Query: 340 ESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEEL 398
++LQE G + Q L + + +DELA E ++ Q + +
Sbjct: 2659 ---------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSI 2702
Query: 399 GAVRLRHEKEVLGVRARYEREL 420
+ L+ E L V A +R+L
Sbjct: 2703 AGLLLKATNEKLSVYAALQRQL 2724
Score = 40.0 bits (92), Expect = 0.006
Identities = 87/388 (22%), Positives = 155/388 (39%), Gaps = 40/388 (10%)
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQ-SLAE 241
++ QE+ RL+ + + L L + D K+ LA Q L+++++ SLA
Sbjct: 867 QEAQEAVTRLEAQHQALVT--------LWHQLHVDMKSLLA-WQSLRRDVQLIRSWSLAT 917
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + E+ + AL +L+ D+Q+ A L A + +
Sbjct: 918 FRTLKPEEQRQ---ALHSLELHYQAFLRDSQD------AGGFGPEDRLMAEREYGSCSHH 968
Query: 302 ELNMLREQTTGLAAELQQQQ--AEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEK 359
+L+ G E + Q+ +E +D+ Q + ++ LR L +E +E
Sbjct: 969 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR-----LPLDKEPAREC 1023
Query: 360 EQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE 419
Q E Q+A+ E + L+ E + + + A LR E E+ + R
Sbjct: 1024 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1083
Query: 420 LRELHEDK-KRQEEELRG-QIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
L ++ +K K +RG Q EE R E E L++ + + A + ++ K ++
Sbjct: 1084 LSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEA-QAVPATLPELEATKASLKKLRA 1141
Query: 478 EAEGKEEELQDVRDQLEQAQE----------ERDCHLKTISSLKQEVKDTVDGQRILEKK 527
+AE ++ +RD+L AQE ERD ++ ++ +
Sbjct: 1142 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1201
Query: 528 GSAALKDLKRQLHLERKRADKLQERLQD 555
L+ L RQL R+ AD L LQD
Sbjct: 1202 RQRELEQLGRQLRYYRESADPLGAWLQD 1229
Score = 38.9 bits (89), Expect = 0.014
Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)
Query: 133 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 189
P EVE + RLL+ +Q L+ + + ++ + +L E+L + +
Sbjct: 436 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 495
Query: 190 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 225
R + E TL D +EE Q R + A+ L
Sbjct: 496 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 555
Query: 226 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 285
+ +QS+ E R + + R + A + Q LL + A
Sbjct: 556 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 615
Query: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 345
SL +L A T+EL L E+ E+ ++ M K + S L L
Sbjct: 616 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 672
Query: 346 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 405
+ +++LQ G ++L +E AR + E +A LQ + +L H
Sbjct: 673 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 721
Query: 406 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 464
KE ++ ++RE ++ +E LR + + A LE L Q ++ + Q++
Sbjct: 722 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 780
Query: 465 MDGAKGWFERRLK 477
G +R K
Sbjct: 781 YKGHLSGLAKRAK 793
Score = 35.0 bits (79), Expect = 0.21
Identities = 50/233 (21%), Positives = 104/233 (44%), Gaps = 26/233 (11%)
Query: 165 QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 223
+A+ R + + +LS + ++ RL + L N S+ ++ L E+ H A
Sbjct: 573 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 628
Query: 224 RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 279
T++L ++E E ++ ++ ++A +R L+ + + + Q + LL
Sbjct: 629 ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 687
Query: 280 AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 336
E++ R ++ E Q A + + + + + A L++ A ++ D+ + L
Sbjct: 688 REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 743
Query: 337 QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML 380
+LQE+LR +RL + LQ+ EKEQL + A++ KA++
Sbjct: 744 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 796
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 99.4 bits (246), Expect = 9e-21
Identities = 131/550 (23%), Positives = 237/550 (43%), Gaps = 78/550 (14%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
L EEE R+Q + +L EL K E+ L A ++E ++ KSK+
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRSTSEKSKQ 1787
Query: 65 AQEVEV-LLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE---AGKFSAVSEGQG 120
E E E A+L + E+ + Q + +++R E A K +A+ E
Sbjct: 1788 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA-- 1845
Query: 121 DPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE 180
++ + E+ +EK E+L+ L + + RL+E+ A+
Sbjct: 1846 ----------------TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1889
Query: 181 KLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQQEL 232
+ +E +L+ ++ + +E+ L+QR++ + + + A K + EL
Sbjct: 1890 DI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946
Query: 233 EAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNALRTS 288
E +S AE LR + Q E AA R L + + +A+E+V+ L AE A R
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2004
Query: 289 LAALEQIQ--TAKTQELNMLREQTTGLAAELQQ--QQAEYEDLMGQK-------DDLNSQ 337
AALE+++ AK +E LRE+ +A Q Q+A + L ++ +
Sbjct: 2005 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2064
Query: 338 LQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEE 397
LQ++L+ +L+QL+ + + +E +EAR AE+ E Q + Q +E
Sbjct: 2065 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----------EAAQSRRQVEE- 2113
Query: 398 LGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEE 457
A RL+ E E + + E+LR + +E AR + E Q + +
Sbjct: 2114 --AERLKQSAE----------EQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQ 2159
Query: 458 LQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDT 517
QA M+ K + E+ L++ E+EL +R QLE+ +++ + + LK E +
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219
Query: 518 VDGQRILEKK 527
+ +E++
Sbjct: 2220 ARQRSQVEEE 2229
Score = 94.0 bits (232), Expect = 4e-19
Identities = 140/621 (22%), Positives = 252/621 (40%), Gaps = 43/621 (6%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA 65
+E E Q ++A+ E Q +E + LR++V + +A+ L+ KA
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAER-------LRRQVQDESQRKRQAEVELASRVKA 1523
Query: 66 QEVEVLLSENEMLQA----KLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGD 121
E E + LQA +L ++E + RL+ + + + + E + SA +E Q
Sbjct: 1524 -EAEAAREKQRALQALEELRLQAEEAERRLRQAEV-ERARQVQVALETAQRSAEAELQSK 1581
Query: 122 PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 181
T L E + +EE +Q QAE R +EE + E+
Sbjct: 1582 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELER 1633
Query: 182 LKKKQESFCRLQTEKETLFND-SRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLA 240
+ K RL+ + E + S + E +Q++EA+ +A R + +E + LA
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA---RRRGKAEEQAVRQRELA 1690
Query: 241 ELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT 300
E ++Q + E A R +Q I+ EQ E + L LA L++ A T
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREAAAAT 1747
Query: 301 QELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE 360
Q+ L + + AE++ A + + + ++ L A + +L E
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 361 QLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE- 419
L +E + R+ AE+ A A L EK E A RL+ E E+ E E
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENER 1865
Query: 420 LRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEA 479
LR L ED+ Q L Q + KA E + + +A ++ KG E L++
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEE-----RLAQLRKASDSELERQKGLVEDTLRQR 1920
Query: 480 EGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 539
EEE+ ++ E+A + + ++ +DT+ + E + + +RQL
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-----QRQL 1975
Query: 540 HL-ERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 598
E +R + +ER+Q L + + + L E+ + + ++ + + +E R
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRLRERAEQESAR 2034
Query: 599 EKESSAVPARVRGKEEPTAPA 619
+ + + A+ R + E A A
Sbjct: 2035 QLQLAQEAAQKRLQAEEKAHA 2055
Score = 94.0 bits (232), Expect = 4e-19
Identities = 134/579 (23%), Positives = 249/579 (43%), Gaps = 58/579 (10%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
+A E+E ++ QL E L +EL++ E T ++ + +++E
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-------- 2232
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
V V + E L+A++ ++ L++ F +E EA K V+E +
Sbjct: 2233 -----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE----EAEKMKQVAE-EAAR 2282
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
A LAE +L + EK +L E++Q ++ E +RL+ E L ++
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQK 2336
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAE 241
+ QE RLQ +KE + + + Q+ EA+ + QL + + ++ +L A S A+
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + +R A + +++ QE+V T + LE +
Sbjct: 2397 ARAEEDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDH 2443
Query: 302 ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQ 361
+ LRE L E ++ Q E + L + +++ + QE L ++ L+Q EK+
Sbjct: 2444 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--SFLSEKDS 2501
Query: 362 LTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELR 421
L Q + E+ KA L++L + + + Q +EE + + E+E + A E R
Sbjct: 2502 LLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557
Query: 422 ELHEDK---KRQEEELRGQIREEKARTREL--ETLQQTVEELQAQVHSMDGAKGWFERRL 476
HE + +R++EEL+ Q+ +++ + EL E Q+ E+LQ A E
Sbjct: 2558 RQHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616
Query: 477 KEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK 536
+ L + RD L+ E + + L+++ V QR L++ G + ++L+
Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VSAQR-LQEAGILSAEELQ 2670
Query: 537 RQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 575
R L D+L R +D+ + RS + L+L N
Sbjct: 2671 R-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2707
Score = 92.0 bits (227), Expect = 1e-18
Identities = 117/505 (23%), Positives = 213/505 (42%), Gaps = 43/505 (8%)
Query: 1 MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
+ Q+ E+ R QAQ + + R+ E +LRQK A D E K +K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2175
Query: 61 KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQG 120
++ + Q+ +V E E+ +L +E D + + K + A + S V E
Sbjct: 2176 QTLR-QKAQV---EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--- 2228
Query: 121 DPPGGPAPTVLAPMPLAEV-ELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLS 179
+ + E+ +LK +E E + L+ + Q E ++++ + +
Sbjct: 2229 -------ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2281
Query: 180 EKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQ--LARTQKLQQELEAANQ 237
QE+ Q +E L + L+++ +A +A A + LQQ+ E A +
Sbjct: 2282 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2341
Query: 238 SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQT 297
L++ ++ + A + Q + A+ Q Q+E + AE L+ +A + + Q
Sbjct: 2342 QARRLQEDKEQMAQQLAEETQGFQRTL---EAERQRQLE-MSAEAERLKLRVAEMSRAQA 2397
Query: 298 AKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ 357
++ R+Q + +L + + ++ + L Q Q+S RL E + E+ +
Sbjct: 2398 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2457
Query: 358 EKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYE 417
EKE+L QE + + +E+ + + E ++ Q Q EK+ L R R+
Sbjct: 2458 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--------SFLSEKDSLLQRERFI 2509
Query: 418 RELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
+ + E + E Q+REE+ R + QQ +E Q V SM+ A+ RR
Sbjct: 2510 EQEKAKLEQLFQDEVAKAQQLREEQQRQQ-----QQMEQERQRLVASMEEAR----RRQH 2560
Query: 478 EAE----GKEEELQDVRDQLEQAQE 498
EAE K+EELQ + Q Q +E
Sbjct: 2561 EAEEGVRRKQEELQQLEQQRRQQEE 2585
Score = 88.6 bits (218), Expect = 2e-17
Identities = 107/465 (23%), Positives = 194/465 (41%), Gaps = 69/465 (14%)
Query: 136 LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 195
LAEVE E +++ + E + R+QEE+ + E Q+ +Q E
Sbjct: 1362 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1421
Query: 196 KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 255
+ L S +I+ ++ EA +++L ++++E+ L QR G E
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1476
Query: 256 ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 293
ALRA ++ Q AQE+ E L AE A R AL+
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 294 QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 342
++ + Q E+ R+ L + +AE + + +QL+ SL
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596
Query: 343 RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 402
+ + QL+E + + Q E + AR+ AE+ +E Q K+ A+R
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1643
Query: 403 LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQV 462
LR + E + + + E +++ +E RG+ E+ R REL +Q +E+ Q Q+
Sbjct: 1644 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL--AEQELEK-QRQL 1700
Query: 463 HSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR 522
A+G ++RL E+EL +R + EQ +++R + ++ L++E ++
Sbjct: 1701 -----AEGTAQQRL----AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1751
Query: 523 ILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE 567
LE + + K + +E A K + + T+ KS+ LE
Sbjct: 1752 ELEAELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1790
Score = 87.8 bits (216), Expect = 3e-17
Identities = 163/704 (23%), Positives = 291/704 (41%), Gaps = 154/704 (21%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
+E+E R++A+ + L +EL + E + QK L+ E +K A+ + +
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1770
Query: 64 KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKER-YGKEAGKFSAVSEGQGDP 122
KA+ E S +E + +L ++ FR L E ++ R +EA + ++E
Sbjct: 1771 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1826
Query: 123 PGGPAPTVLAPMPLAEVE---LKWEME--KEEKRLLWEQLQGLESSKQAETSRLQEELAK 177
A VLA A E LK E E +EK E+L+ L + + RL+E+ A+
Sbjct: 1827 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1886
Query: 178 LSEKLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQ 229
+ +E +L+ ++ + +E+ L+QR++ + + + A K +
Sbjct: 1887 HKADI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 230 QELEAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNAL 285
ELE +S AE LR + Q E AA R L + + +A+E+V+ L AE A
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 286 RTSLAALEQIQT--AKTQELNMLREQTTGLAAE--------------------------- 316
R AALE+++ AK +E LRE+ +A
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061
Query: 317 -------LQQQQAEYEDLMGQKDDLNSQLQESLRA----------NSRLLEQLQEIGQEK 359
LQQ+Q+ + L G+ + +E+ A + R +E+ + + Q
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121
Query: 360 EQLTQELQEARKSAEK----------RKAMLDELAM------------------ETLQEK 391
E+ Q +A+ +AEK R+A ++ A+ +TL++K
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181
Query: 392 SQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL-------RELH 424
+Q ++EL +RL+ H+K +L R++ E EL EL
Sbjct: 2182 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241
Query: 425 EDKKRQEEELRGQIREEKARTR-----ELETLQQTVEEL--------------QAQVHSM 465
+ K R E E R I +K T+ E E ++Q EE Q +
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2301
Query: 466 DGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE 525
+ E+ LKE +E ++ + E Q++++ + L QE K+ + Q E
Sbjct: 2302 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL-QEDKEQMAQQLAEE 2360
Query: 526 KKGSAALKDLKRQLHLERK-RADKLQERLQDILTNSKSRSGLEE 568
+G + +RQ LE A++L+ R+ ++ S++++ EE
Sbjct: 2361 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEM---SRAQARAEE 2401
Score = 82.0 bits (201), Expect = 1e-15
Identities = 115/491 (23%), Positives = 210/491 (42%), Gaps = 59/491 (12%)
Query: 166 AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 225
+ET R EE +L+E+ + ++ RL E E R E Q K +
Sbjct: 1338 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1394
Query: 226 QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 282
Q++Q+E+ ++ + + Q++ E L+ + Q + A+A E+ + E
Sbjct: 1395 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1454
Query: 283 NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 341
+R L A E+ + EL LR + A+ +Q Q E E L Q +D+ + Q
Sbjct: 1455 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1514
Query: 342 LRANSRLLEQLQEIGQEKEQLTQELQEAR----------KSAEKRKAMLDELAMETLQ-- 389
+ SR+ + E +EK++ Q L+E R + AE +A ++A+ET Q
Sbjct: 1515 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573
Query: 390 -------------------EKSQHKEELGAVRLRHEKE------VLGVRARYERELRELH 424
E+S +E + +LR E E RAR E E REL
Sbjct: 1574 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELE 1632
Query: 425 EDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKE 483
+ + E LR +++ EE A+ + L + ++ +A+ + K E+ +++ E E
Sbjct: 1633 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQRELAE 1691
Query: 484 EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLER 543
+EL+ R E ++R + + L+ E + +++LE ++L R L+R
Sbjct: 1692 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-------EELAR---LQR 1741
Query: 544 KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 603
+ A Q+R + +K R+ +E L+ S+ + +++ S E R +E +
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE-AEAGRFRELA 1800
Query: 604 AVPARVRGKEE 614
AR+R E
Sbjct: 1801 EEAARLRALAE 1811
Score = 81.6 bits (200), Expect = 2e-15
Identities = 153/612 (25%), Positives = 241/612 (39%), Gaps = 98/612 (16%)
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
K+AQ V L E E +A L Q T A + R +E G+ G+ D
Sbjct: 1113 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD- 1171
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
EVE +W +E L E+ Q + A+T Q EL +L +L
Sbjct: 1172 --------------VEVE-RW---RERVAQLLERWQAV----LAQTDVRQRELEQLGRQL 1209
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKA---QLARTQKLQQELEAANQSL 239
+ +ES L D+R + E++Q AD +A QL + Q L +E+E
Sbjct: 1210 RYYRESADPLGA----WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE------ 1259
Query: 240 AELRDQRQGERLEHAAA-----LRALQD-QVSIQSADAQ-EQVEGLLAENNALRTSLAAL 292
R GE++E + A++D ++ + + AQ E V + S + +
Sbjct: 1260 ------RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313
Query: 293 EQIQTAKTQ--ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLE 350
++ +T EL L Q +E ++ E E L Q+ + + A
Sbjct: 1314 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1373
Query: 351 QLQEI-GQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEV 409
QL E Q K Q +E +E ++ ++ +E A++ Q+K +EEL +R E E+
Sbjct: 1374 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1433
Query: 410 LG----------VRARYERELRELH---EDKKRQEEELRGQIREEKARTRELET----LQ 452
R R E E+R + E +RQ G+++ +AR E E Q
Sbjct: 1434 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1493
Query: 453 QTVEELQAQVHSMDGAKGWFERRL-----KEAEGKEEE------LQDVRDQLEQAQEERD 501
+ E L+ QV K E L EAE E+ L+++R Q E+A ER
Sbjct: 1494 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERR 1551
Query: 502 CHLKTISSLKQEVKDTVDGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE--- 551
+ +Q QR E K+ S A K L+R L E +L+E
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1611
Query: 552 -RLQDILTNSKSRSGLE-ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAV 605
R Q ++R E EL ++ + R Q + + S + E ++KE +
Sbjct: 1612 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1671
Query: 606 PARVRGKEEPTA 617
AR RGK E A
Sbjct: 1672 EARRRGKAEEQA 1683
Score = 65.5 bits (158), Expect = 1e-10
Identities = 91/442 (20%), Positives = 182/442 (41%), Gaps = 62/442 (14%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKA-----QK 57
QA+ E + +A+LL+ + Q ++ R+ + + Q++A + F + Q+
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2374
Query: 58 ALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSE 117
L S +A+ +++ ++E QA+ + FR Q + + + + K + V
Sbjct: 2375 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQT 2433
Query: 118 GQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQE 173
+ +AE+E + E ++E +LL + + +++ +Q ET LQ+
Sbjct: 2434 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2493
Query: 174 ELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELE 233
+ L +++ + + + E LF D K ++L++ + Q+ QQ++E
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQME 2542
Query: 234 AANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALE 293
Q L ++ + + E +R Q+++ ++Q E L EN LR L LE
Sbjct: 2543 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2602
Query: 294 Q--------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ 339
+ Q A T+ L R+ G AAE + + + D L ++
Sbjct: 2603 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS 2654
Query: 340 ESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEEL 398
++LQE G + Q L + + +DELA E ++ Q + +
Sbjct: 2655 ---------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSI 2698
Query: 399 GAVRLRHEKEVLGVRARYEREL 420
+ L+ E L V A +R+L
Sbjct: 2699 AGLLLKATNEKLSVYAALQRQL 2720
Score = 40.0 bits (92), Expect = 0.006
Identities = 87/388 (22%), Positives = 155/388 (39%), Gaps = 40/388 (10%)
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQ-SLAE 241
++ QE+ RL+ + + L L + D K+ LA Q L+++++ SLA
Sbjct: 863 QEAQEAVTRLEAQHQALVT--------LWHQLHVDMKSLLA-WQSLRRDVQLIRSWSLAT 913
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + E+ + AL +L+ D+Q+ A L A + +
Sbjct: 914 FRTLKPEEQRQ---ALHSLELHYQAFLRDSQD------AGGFGPEDRLMAEREYGSCSHH 964
Query: 302 ELNMLREQTTGLAAELQQQQ--AEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEK 359
+L+ G E + Q+ +E +D+ Q + ++ LR L +E +E
Sbjct: 965 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR-----LPLDKEPAREC 1019
Query: 360 EQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE 419
Q E Q+A+ E + L+ E + + + A LR E E+ + R
Sbjct: 1020 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1079
Query: 420 LRELHEDK-KRQEEELRG-QIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
L ++ +K K +RG Q EE R E E L++ + + A + ++ K ++
Sbjct: 1080 LSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEA-QAVPATLPELEATKASLKKLRA 1137
Query: 478 EAEGKEEELQDVRDQLEQAQE----------ERDCHLKTISSLKQEVKDTVDGQRILEKK 527
+AE ++ +RD+L AQE ERD ++ ++ +
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1197
Query: 528 GSAALKDLKRQLHLERKRADKLQERLQD 555
L+ L RQL R+ AD L LQD
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQD 1225
Score = 38.9 bits (89), Expect = 0.014
Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)
Query: 133 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 189
P EVE + RLL+ +Q L+ + + ++ + +L E+L + +
Sbjct: 432 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 491
Query: 190 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 225
R + E TL D +EE Q R + A+ L
Sbjct: 492 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 551
Query: 226 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 285
+ +QS+ E R + + R + A + Q LL + A
Sbjct: 552 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 611
Query: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 345
SL +L A T+EL L E+ E+ ++ M K + S L L
Sbjct: 612 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 668
Query: 346 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 405
+ +++LQ G ++L +E AR + E +A LQ + +L H
Sbjct: 669 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 717
Query: 406 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 464
KE ++ ++RE ++ +E LR + + A LE L Q ++ + Q++
Sbjct: 718 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 776
Query: 465 MDGAKGWFERRLK 477
G +R K
Sbjct: 777 YKGHLSGLAKRAK 789
Score = 35.0 bits (79), Expect = 0.21
Identities = 50/233 (21%), Positives = 104/233 (44%), Gaps = 26/233 (11%)
Query: 165 QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 223
+A+ R + + +LS + ++ RL + L N S+ ++ L E+ H A
Sbjct: 569 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 624
Query: 224 RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 279
T++L ++E E ++ ++ ++A +R L+ + + + Q + LL
Sbjct: 625 ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 683
Query: 280 AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 336
E++ R ++ E Q A + + + + + A L++ A ++ D+ + L
Sbjct: 684 REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 739
Query: 337 QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML 380
+LQE+LR +RL + LQ+ EKEQL + A++ KA++
Sbjct: 740 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 792
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 99.4 bits (246), Expect = 9e-21
Identities = 131/550 (23%), Positives = 237/550 (43%), Gaps = 78/550 (14%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
L EEE R+Q + +L EL K E+ L A ++E ++ KSK+
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRSTSEKSKQ 1755
Query: 65 AQEVEV-LLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE---AGKFSAVSEGQG 120
E E E A+L + E+ + Q + +++R E A K +A+ E
Sbjct: 1756 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA-- 1813
Query: 121 DPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE 180
++ + E+ +EK E+L+ L + + RL+E+ A+
Sbjct: 1814 ----------------TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1857
Query: 181 KLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQQEL 232
+ +E +L+ ++ + +E+ L+QR++ + + + A K + EL
Sbjct: 1858 DI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1914
Query: 233 EAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNALRTS 288
E +S AE LR + Q E AA R L + + +A+E+V+ L AE A R
Sbjct: 1915 ELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 1972
Query: 289 LAALEQIQ--TAKTQELNMLREQTTGLAAELQQ--QQAEYEDLMGQK-------DDLNSQ 337
AALE+++ AK +E LRE+ +A Q Q+A + L ++ +
Sbjct: 1973 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2032
Query: 338 LQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEE 397
LQ++L+ +L+QL+ + + +E +EAR AE+ E Q + Q +E
Sbjct: 2033 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----------EAAQSRRQVEE- 2081
Query: 398 LGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEE 457
A RL+ E E + + E+LR + +E AR + E Q + +
Sbjct: 2082 --AERLKQSAE----------EQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQ 2127
Query: 458 LQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDT 517
QA M+ K + E+ L++ E+EL +R QLE+ +++ + + LK E +
Sbjct: 2128 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2187
Query: 518 VDGQRILEKK 527
+ +E++
Sbjct: 2188 ARQRSQVEEE 2197
Score = 94.0 bits (232), Expect = 4e-19
Identities = 140/621 (22%), Positives = 252/621 (40%), Gaps = 43/621 (6%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA 65
+E E Q ++A+ E Q +E + LR++V + +A+ L+ KA
Sbjct: 1439 AEGELQALRARAEEAEAQKRQAQEEAER-------LRRQVQDESQRKRQAEVELASRVKA 1491
Query: 66 QEVEVLLSENEMLQA----KLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGD 121
E E + LQA +L ++E + RL+ + + + + E + SA +E Q
Sbjct: 1492 -EAEAAREKQRALQALEELRLQAEEAERRLRQAEV-ERARQVQVALETAQRSAEAELQSK 1549
Query: 122 PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 181
T L E + +EE +Q QAE R +EE + E+
Sbjct: 1550 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELER 1601
Query: 182 LKKKQESFCRLQTEKETLFND-SRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLA 240
+ K RL+ + E + S + E +Q++EA+ +A R + +E + LA
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA---RRRGKAEEQAVRQRELA 1658
Query: 241 ELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT 300
E ++Q + E A R +Q I+ EQ E + L LA L++ A T
Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREAAAAT 1715
Query: 301 QELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE 360
Q+ L + + AE++ A + + + ++ L A + +L E
Sbjct: 1716 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1775
Query: 361 QLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE- 419
L +E + R+ AE+ A A L EK E A RL+ E E+ E E
Sbjct: 1776 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENER 1833
Query: 420 LRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEA 479
LR L ED+ Q L Q + KA E + + +A ++ KG E L++
Sbjct: 1834 LRRLAEDEAFQRRRLEEQAAQHKADIEE-----RLAQLRKASDSELERQKGLVEDTLRQR 1888
Query: 480 EGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 539
EEE+ ++ E+A + + ++ +DT+ + E + + +RQL
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-----QRQL 1943
Query: 540 HL-ERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 598
E +R + +ER+Q L + + + L E+ + + ++ + + +E R
Sbjct: 1944 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRLRERAEQESAR 2002
Query: 599 EKESSAVPARVRGKEEPTAPA 619
+ + + A+ R + E A A
Sbjct: 2003 QLQLAQEAAQKRLQAEEKAHA 2023
Score = 94.0 bits (232), Expect = 4e-19
Identities = 134/579 (23%), Positives = 249/579 (43%), Gaps = 58/579 (10%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
+A E+E ++ QL E L +EL++ E T ++ + +++E
Sbjct: 2149 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-------- 2200
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
V V + E L+A++ ++ L++ F +E EA K V+E +
Sbjct: 2201 -----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE----EAEKMKQVAE-EAAR 2250
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
A LAE +L + EK +L E++Q ++ E +RL+ E L ++
Sbjct: 2251 LSVAAQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQK 2304
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAE 241
+ QE RLQ +KE + + + Q+ EA+ + QL + + ++ +L A S A+
Sbjct: 2305 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2364
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + +R A + +++ QE+V T + LE +
Sbjct: 2365 ARAEEDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDH 2411
Query: 302 ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQ 361
+ LRE L E ++ Q E + L + +++ + QE L ++ L+Q EK+
Sbjct: 2412 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--SFLSEKDS 2469
Query: 362 LTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELR 421
L Q + E+ KA L++L + + + Q +EE + + E+E + A E R
Sbjct: 2470 LLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2525
Query: 422 ELHEDK---KRQEEELRGQIREEKARTREL--ETLQQTVEELQAQVHSMDGAKGWFERRL 476
HE + +R++EEL+ Q+ +++ + EL E Q+ E+LQ A E
Sbjct: 2526 RQHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2584
Query: 477 KEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK 536
+ L + RD L+ E + + L+++ V QR L++ G + ++L+
Sbjct: 2585 ASQVAATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VSAQR-LQEAGILSAEELQ 2638
Query: 537 RQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 575
R L D+L R +D+ + RS + L+L N
Sbjct: 2639 R-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2675
Score = 92.0 bits (227), Expect = 1e-18
Identities = 117/505 (23%), Positives = 213/505 (42%), Gaps = 43/505 (8%)
Query: 1 MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
+ Q+ E+ R QAQ + + R+ E +LRQK A D E K +K
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2143
Query: 61 KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQG 120
++ + Q+ +V E E+ +L +E D + + K + A + S V E
Sbjct: 2144 QTLR-QKAQV---EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--- 2196
Query: 121 DPPGGPAPTVLAPMPLAEV-ELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLS 179
+ + E+ +LK +E E + L+ + Q E ++++ + +
Sbjct: 2197 -------ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2249
Query: 180 EKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQ--LARTQKLQQELEAANQ 237
QE+ Q +E L + L+++ +A +A A + LQQ+ E A +
Sbjct: 2250 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2309
Query: 238 SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQT 297
L++ ++ + A + Q + A+ Q Q+E + AE L+ +A + + Q
Sbjct: 2310 QARRLQEDKEQMAQQLAEETQGFQRTL---EAERQRQLE-MSAEAERLKLRVAEMSRAQA 2365
Query: 298 AKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ 357
++ R+Q + +L + + ++ + L Q Q+S RL E + E+ +
Sbjct: 2366 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2425
Query: 358 EKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYE 417
EKE+L QE + + +E+ + + E ++ Q Q EK+ L R R+
Sbjct: 2426 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--------SFLSEKDSLLQRERFI 2477
Query: 418 RELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
+ + E + E Q+REE+ R + QQ +E Q V SM+ A+ RR
Sbjct: 2478 EQEKAKLEQLFQDEVAKAQQLREEQQRQQ-----QQMEQERQRLVASMEEAR----RRQH 2528
Query: 478 EAE----GKEEELQDVRDQLEQAQE 498
EAE K+EELQ + Q Q +E
Sbjct: 2529 EAEEGVRRKQEELQQLEQQRRQQEE 2553
Score = 88.6 bits (218), Expect = 2e-17
Identities = 107/465 (23%), Positives = 194/465 (41%), Gaps = 69/465 (14%)
Query: 136 LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 195
LAEVE E +++ + E + R+QEE+ + E Q+ +Q E
Sbjct: 1330 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1389
Query: 196 KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 255
+ L S +I+ ++ EA +++L ++++E+ L QR G E
Sbjct: 1390 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1444
Query: 256 ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 293
ALRA ++ Q AQE+ E L AE A R AL+
Sbjct: 1445 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504
Query: 294 QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 342
++ + Q E+ R+ L + +AE + + +QL+ SL
Sbjct: 1505 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1564
Query: 343 RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 402
+ + QL+E + + Q E + AR+ AE+ +E Q K+ A+R
Sbjct: 1565 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1611
Query: 403 LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQV 462
LR + E + + + E +++ +E RG+ E+ R REL +Q +E+ Q Q+
Sbjct: 1612 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL--AEQELEK-QRQL 1668
Query: 463 HSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR 522
A+G ++RL E+EL +R + EQ +++R + ++ L++E ++
Sbjct: 1669 -----AEGTAQQRL----AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1719
Query: 523 ILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE 567
LE + + K + +E A K + + T+ KS+ LE
Sbjct: 1720 ELEAELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1758
Score = 87.8 bits (216), Expect = 3e-17
Identities = 163/704 (23%), Positives = 291/704 (41%), Gaps = 154/704 (21%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
+E+E R++A+ + L +EL + E + QK L+ E +K A+ + +
Sbjct: 1679 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1738
Query: 64 KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKER-YGKEAGKFSAVSEGQGDP 122
KA+ E S +E + +L ++ FR L E ++ R +EA + ++E
Sbjct: 1739 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1794
Query: 123 PGGPAPTVLAPMPLAEVE---LKWEME--KEEKRLLWEQLQGLESSKQAETSRLQEELAK 177
A VLA A E LK E E +EK E+L+ L + + RL+E+ A+
Sbjct: 1795 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1854
Query: 178 LSEKLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQ 229
+ +E +L+ ++ + +E+ L+QR++ + + + A K +
Sbjct: 1855 HKADI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1911
Query: 230 QELEAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNAL 285
ELE +S AE LR + Q E AA R L + + +A+E+V+ L AE A
Sbjct: 1912 LELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1969
Query: 286 RTSLAALEQIQT--AKTQELNMLREQTTGLAAE--------------------------- 316
R AALE+++ AK +E LRE+ +A
Sbjct: 1970 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029
Query: 317 -------LQQQQAEYEDLMGQKDDLNSQLQESLRA----------NSRLLEQLQEIGQEK 359
LQQ+Q+ + L G+ + +E+ A + R +E+ + + Q
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2089
Query: 360 EQLTQELQEARKSAEK----------RKAMLDELAM------------------ETLQEK 391
E+ Q +A+ +AEK R+A ++ A+ +TL++K
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2149
Query: 392 SQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL-------RELH 424
+Q ++EL +RL+ H+K +L R++ E EL EL
Sbjct: 2150 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2209
Query: 425 EDKKRQEEELRGQIREEKARTR-----ELETLQQTVEEL--------------QAQVHSM 465
+ K R E E R I +K T+ E E ++Q EE Q +
Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2269
Query: 466 DGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE 525
+ E+ LKE +E ++ + E Q++++ + L QE K+ + Q E
Sbjct: 2270 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL-QEDKEQMAQQLAEE 2328
Query: 526 KKGSAALKDLKRQLHLERK-RADKLQERLQDILTNSKSRSGLEE 568
+G + +RQ LE A++L+ R+ ++ S++++ EE
Sbjct: 2329 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEM---SRAQARAEE 2369
Score = 82.0 bits (201), Expect = 1e-15
Identities = 115/491 (23%), Positives = 210/491 (42%), Gaps = 59/491 (12%)
Query: 166 AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 225
+ET R EE +L+E+ + ++ RL E E R E Q K +
Sbjct: 1306 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1362
Query: 226 QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 282
Q++Q+E+ ++ + + Q++ E L+ + Q + A+A E+ + E
Sbjct: 1363 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1422
Query: 283 NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 341
+R L A E+ + EL LR + A+ +Q Q E E L Q +D+ + Q
Sbjct: 1423 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1482
Query: 342 LRANSRLLEQLQEIGQEKEQLTQELQEAR----------KSAEKRKAMLDELAMETLQ-- 389
+ SR+ + E +EK++ Q L+E R + AE +A ++A+ET Q
Sbjct: 1483 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1541
Query: 390 -------------------EKSQHKEELGAVRLRHEKE------VLGVRARYERELRELH 424
E+S +E + +LR E E RAR E E REL
Sbjct: 1542 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELE 1600
Query: 425 EDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKE 483
+ + E LR +++ EE A+ + L + ++ +A+ + K E+ +++ E E
Sbjct: 1601 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQRELAE 1659
Query: 484 EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLER 543
+EL+ R E ++R + + L+ E + +++LE ++L R L+R
Sbjct: 1660 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-------EELAR---LQR 1709
Query: 544 KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 603
+ A Q+R + +K R+ +E L+ S+ + +++ S E R +E +
Sbjct: 1710 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE-AEAGRFRELA 1768
Query: 604 AVPARVRGKEE 614
AR+R E
Sbjct: 1769 EEAARLRALAE 1779
Score = 81.6 bits (200), Expect = 2e-15
Identities = 153/612 (25%), Positives = 241/612 (39%), Gaps = 98/612 (16%)
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
K+AQ V L E E +A L Q T A + R +E G+ G+ D
Sbjct: 1081 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD- 1139
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
EVE +W +E L E+ Q + A+T Q EL +L +L
Sbjct: 1140 --------------VEVE-RW---RERVAQLLERWQAV----LAQTDVRQRELEQLGRQL 1177
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKA---QLARTQKLQQELEAANQSL 239
+ +ES L D+R + E++Q AD +A QL + Q L +E+E
Sbjct: 1178 RYYRESADPLGA----WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE------ 1227
Query: 240 AELRDQRQGERLEHAAA-----LRALQD-QVSIQSADAQ-EQVEGLLAENNALRTSLAAL 292
R GE++E + A++D ++ + + AQ E V + S + +
Sbjct: 1228 ------RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1281
Query: 293 EQIQTAKTQ--ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLE 350
++ +T EL L Q +E ++ E E L Q+ + + A
Sbjct: 1282 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1341
Query: 351 QLQEI-GQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEV 409
QL E Q K Q +E +E ++ ++ +E A++ Q+K +EEL +R E E+
Sbjct: 1342 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1401
Query: 410 LG----------VRARYERELRELH---EDKKRQEEELRGQIREEKARTRELET----LQ 452
R R E E+R + E +RQ G+++ +AR E E Q
Sbjct: 1402 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1461
Query: 453 QTVEELQAQVHSMDGAKGWFERRL-----KEAEGKEEE------LQDVRDQLEQAQEERD 501
+ E L+ QV K E L EAE E+ L+++R Q E+A ER
Sbjct: 1462 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERR 1519
Query: 502 CHLKTISSLKQEVKDTVDGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE--- 551
+ +Q QR E K+ S A K L+R L E +L+E
Sbjct: 1520 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1579
Query: 552 -RLQDILTNSKSRSGLE-ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAV 605
R Q ++R E EL ++ + R Q + + S + E ++KE +
Sbjct: 1580 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1639
Query: 606 PARVRGKEEPTA 617
AR RGK E A
Sbjct: 1640 EARRRGKAEEQA 1651
Score = 65.5 bits (158), Expect = 1e-10
Identities = 91/442 (20%), Positives = 182/442 (41%), Gaps = 62/442 (14%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKA-----QK 57
QA+ E + +A+LL+ + Q ++ R+ + + Q++A + F + Q+
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2342
Query: 58 ALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSE 117
L S +A+ +++ ++E QA+ + FR Q + + + + K + V
Sbjct: 2343 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQT 2401
Query: 118 GQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQE 173
+ +AE+E + E ++E +LL + + +++ +Q ET LQ+
Sbjct: 2402 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2461
Query: 174 ELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELE 233
+ L +++ + + + E LF D K ++L++ + Q+ QQ++E
Sbjct: 2462 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQME 2510
Query: 234 AANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALE 293
Q L ++ + + E +R Q+++ ++Q E L EN LR L LE
Sbjct: 2511 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2570
Query: 294 Q--------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ 339
+ Q A T+ L R+ G AAE + + + D L ++
Sbjct: 2571 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS 2622
Query: 340 ESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEEL 398
++LQE G + Q L + + +DELA E ++ Q + +
Sbjct: 2623 ---------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSI 2666
Query: 399 GAVRLRHEKEVLGVRARYEREL 420
+ L+ E L V A +R+L
Sbjct: 2667 AGLLLKATNEKLSVYAALQRQL 2688
Score = 40.0 bits (92), Expect = 0.006
Identities = 87/388 (22%), Positives = 155/388 (39%), Gaps = 40/388 (10%)
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQ-SLAE 241
++ QE+ RL+ + + L L + D K+ LA Q L+++++ SLA
Sbjct: 831 QEAQEAVTRLEAQHQALVT--------LWHQLHVDMKSLLA-WQSLRRDVQLIRSWSLAT 881
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + E+ + AL +L+ D+Q+ A L A + +
Sbjct: 882 FRTLKPEEQRQ---ALHSLELHYQAFLRDSQD------AGGFGPEDRLMAEREYGSCSHH 932
Query: 302 ELNMLREQTTGLAAELQQQQ--AEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEK 359
+L+ G E + Q+ +E +D+ Q + ++ LR L +E +E
Sbjct: 933 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR-----LPLDKEPAREC 987
Query: 360 EQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE 419
Q E Q+A+ E + L+ E + + + A LR E E+ + R
Sbjct: 988 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1047
Query: 420 LRELHEDK-KRQEEELRG-QIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
L ++ +K K +RG Q EE R E E L++ + + A + ++ K ++
Sbjct: 1048 LSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEA-QAVPATLPELEATKASLKKLRA 1105
Query: 478 EAEGKEEELQDVRDQLEQAQE----------ERDCHLKTISSLKQEVKDTVDGQRILEKK 527
+AE ++ +RD+L AQE ERD ++ ++ +
Sbjct: 1106 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1165
Query: 528 GSAALKDLKRQLHLERKRADKLQERLQD 555
L+ L RQL R+ AD L LQD
Sbjct: 1166 RQRELEQLGRQLRYYRESADPLGAWLQD 1193
Score = 38.9 bits (89), Expect = 0.014
Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)
Query: 133 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 189
P EVE + RLL+ +Q L+ + + ++ + +L E+L + +
Sbjct: 400 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 459
Query: 190 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 225
R + E TL D +EE Q R + A+ L
Sbjct: 460 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 519
Query: 226 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 285
+ +QS+ E R + + R + A + Q LL + A
Sbjct: 520 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 579
Query: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 345
SL +L A T+EL L E+ E+ ++ M K + S L L
Sbjct: 580 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 636
Query: 346 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 405
+ +++LQ G ++L +E AR + E +A LQ + +L H
Sbjct: 637 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 685
Query: 406 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 464
KE ++ ++RE ++ +E LR + + A LE L Q ++ + Q++
Sbjct: 686 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 744
Query: 465 MDGAKGWFERRLK 477
G +R K
Sbjct: 745 YKGHLSGLAKRAK 757
Score = 35.0 bits (79), Expect = 0.21
Identities = 50/233 (21%), Positives = 104/233 (44%), Gaps = 26/233 (11%)
Query: 165 QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 223
+A+ R + + +LS + ++ RL + L N S+ ++ L E+ H A
Sbjct: 537 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 592
Query: 224 RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 279
T++L ++E E ++ ++ ++A +R L+ + + + Q + LL
Sbjct: 593 ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 651
Query: 280 AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 336
E++ R ++ E Q A + + + + + A L++ A ++ D+ + L
Sbjct: 652 REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 707
Query: 337 QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML 380
+LQE+LR +RL + LQ+ EKEQL + A++ KA++
Sbjct: 708 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 760
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 99.4 bits (246), Expect = 9e-21
Identities = 131/550 (23%), Positives = 237/550 (43%), Gaps = 78/550 (14%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
L EEE R+Q + +L EL K E+ L A ++E ++ KSK+
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRSTSEKSKQ 1924
Query: 65 AQEVEV-LLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE---AGKFSAVSEGQG 120
E E E A+L + E+ + Q + +++R E A K +A+ E
Sbjct: 1925 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA-- 1982
Query: 121 DPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE 180
++ + E+ +EK E+L+ L + + RL+E+ A+
Sbjct: 1983 ----------------TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 2026
Query: 181 KLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQQEL 232
+ +E +L+ ++ + +E+ L+QR++ + + + A K + EL
Sbjct: 2027 DI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 2083
Query: 233 EAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNALRTS 288
E +S AE LR + Q E AA R L + + +A+E+V+ L AE A R
Sbjct: 2084 ELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2141
Query: 289 LAALEQIQ--TAKTQELNMLREQTTGLAAELQQ--QQAEYEDLMGQK-------DDLNSQ 337
AALE+++ AK +E LRE+ +A Q Q+A + L ++ +
Sbjct: 2142 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2201
Query: 338 LQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEE 397
LQ++L+ +L+QL+ + + +E +EAR AE+ E Q + Q +E
Sbjct: 2202 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----------EAAQSRRQVEE- 2250
Query: 398 LGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEE 457
A RL+ E E + + E+LR + +E AR + E Q + +
Sbjct: 2251 --AERLKQSAE----------EQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQ 2296
Query: 458 LQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDT 517
QA M+ K + E+ L++ E+EL +R QLE+ +++ + + LK E +
Sbjct: 2297 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2356
Query: 518 VDGQRILEKK 527
+ +E++
Sbjct: 2357 ARQRSQVEEE 2366
Score = 94.0 bits (232), Expect = 4e-19
Identities = 140/621 (22%), Positives = 252/621 (40%), Gaps = 43/621 (6%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA 65
+E E Q ++A+ E Q +E + LR++V + +A+ L+ KA
Sbjct: 1608 AEGELQALRARAEEAEAQKRQAQEEAER-------LRRQVQDESQRKRQAEVELASRVKA 1660
Query: 66 QEVEVLLSENEMLQA----KLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGD 121
E E + LQA +L ++E + RL+ + + + + E + SA +E Q
Sbjct: 1661 -EAEAAREKQRALQALEELRLQAEEAERRLRQAEV-ERARQVQVALETAQRSAEAELQSK 1718
Query: 122 PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 181
T L E + +EE +Q QAE R +EE + E+
Sbjct: 1719 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELER 1770
Query: 182 LKKKQESFCRLQTEKETLFND-SRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLA 240
+ K RL+ + E + S + E +Q++EA+ +A R + +E + LA
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA---RRRGKAEEQAVRQRELA 1827
Query: 241 ELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT 300
E ++Q + E A R +Q I+ EQ E + L LA L++ A T
Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREAAAAT 1884
Query: 301 QELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE 360
Q+ L + + AE++ A + + + ++ L A + +L E
Sbjct: 1885 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1944
Query: 361 QLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE- 419
L +E + R+ AE+ A A L EK E A RL+ E E+ E E
Sbjct: 1945 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENER 2002
Query: 420 LRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEA 479
LR L ED+ Q L Q + KA E + + +A ++ KG E L++
Sbjct: 2003 LRRLAEDEAFQRRRLEEQAAQHKADIEE-----RLAQLRKASDSELERQKGLVEDTLRQR 2057
Query: 480 EGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 539
EEE+ ++ E+A + + ++ +DT+ + E + + +RQL
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-----QRQL 2112
Query: 540 HL-ERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 598
E +R + +ER+Q L + + + L E+ + + ++ + + +E R
Sbjct: 2113 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRLRERAEQESAR 2171
Query: 599 EKESSAVPARVRGKEEPTAPA 619
+ + + A+ R + E A A
Sbjct: 2172 QLQLAQEAAQKRLQAEEKAHA 2192
Score = 94.0 bits (232), Expect = 4e-19
Identities = 134/579 (23%), Positives = 249/579 (43%), Gaps = 58/579 (10%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
+A E+E ++ QL E L +EL++ E T ++ + +++E
Sbjct: 2318 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-------- 2369
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
V V + E L+A++ ++ L++ F +E EA K V+E +
Sbjct: 2370 -----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE----EAEKMKQVAE-EAAR 2419
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
A LAE +L + EK +L E++Q ++ E +RL+ E L ++
Sbjct: 2420 LSVAAQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQK 2473
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAE 241
+ QE RLQ +KE + + + Q+ EA+ + QL + + ++ +L A S A+
Sbjct: 2474 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2533
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + +R A + +++ QE+V T + LE +
Sbjct: 2534 ARAEEDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDH 2580
Query: 302 ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQ 361
+ LRE L E ++ Q E + L + +++ + QE L ++ L+Q EK+
Sbjct: 2581 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--SFLSEKDS 2638
Query: 362 LTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELR 421
L Q + E+ KA L++L + + + Q +EE + + E+E + A E R
Sbjct: 2639 LLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694
Query: 422 ELHEDK---KRQEEELRGQIREEKARTREL--ETLQQTVEELQAQVHSMDGAKGWFERRL 476
HE + +R++EEL+ Q+ +++ + EL E Q+ E+LQ A E
Sbjct: 2695 RQHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2753
Query: 477 KEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK 536
+ L + RD L+ E + + L+++ V QR L++ G + ++L+
Sbjct: 2754 ASQVAATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VSAQR-LQEAGILSAEELQ 2807
Query: 537 RQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 575
R L D+L R +D+ + RS + L+L N
Sbjct: 2808 R-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2844
Score = 92.0 bits (227), Expect = 1e-18
Identities = 117/505 (23%), Positives = 213/505 (42%), Gaps = 43/505 (8%)
Query: 1 MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
+ Q+ E+ R QAQ + + R+ E +LRQK A D E K +K
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2312
Query: 61 KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQG 120
++ + Q+ +V E E+ +L +E D + + K + A + S V E
Sbjct: 2313 QTLR-QKAQV---EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--- 2365
Query: 121 DPPGGPAPTVLAPMPLAEV-ELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLS 179
+ + E+ +LK +E E + L+ + Q E ++++ + +
Sbjct: 2366 -------ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2418
Query: 180 EKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQ--LARTQKLQQELEAANQ 237
QE+ Q +E L + L+++ +A +A A + LQQ+ E A +
Sbjct: 2419 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2478
Query: 238 SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQT 297
L++ ++ + A + Q + A+ Q Q+E + AE L+ +A + + Q
Sbjct: 2479 QARRLQEDKEQMAQQLAEETQGFQRTL---EAERQRQLE-MSAEAERLKLRVAEMSRAQA 2534
Query: 298 AKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ 357
++ R+Q + +L + + ++ + L Q Q+S RL E + E+ +
Sbjct: 2535 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2594
Query: 358 EKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYE 417
EKE+L QE + + +E+ + + E ++ Q Q EK+ L R R+
Sbjct: 2595 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--------SFLSEKDSLLQRERFI 2646
Query: 418 RELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
+ + E + E Q+REE+ R + QQ +E Q V SM+ A+ RR
Sbjct: 2647 EQEKAKLEQLFQDEVAKAQQLREEQQRQQ-----QQMEQERQRLVASMEEAR----RRQH 2697
Query: 478 EAE----GKEEELQDVRDQLEQAQE 498
EAE K+EELQ + Q Q +E
Sbjct: 2698 EAEEGVRRKQEELQQLEQQRRQQEE 2722
Score = 88.6 bits (218), Expect = 2e-17
Identities = 107/465 (23%), Positives = 194/465 (41%), Gaps = 69/465 (14%)
Query: 136 LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 195
LAEVE E +++ + E + R+QEE+ + E Q+ +Q E
Sbjct: 1499 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1558
Query: 196 KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 255
+ L S +I+ ++ EA +++L ++++E+ L QR G E
Sbjct: 1559 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1613
Query: 256 ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 293
ALRA ++ Q AQE+ E L AE A R AL+
Sbjct: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673
Query: 294 QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 342
++ + Q E+ R+ L + +AE + + +QL+ SL
Sbjct: 1674 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1733
Query: 343 RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 402
+ + QL+E + + Q E + AR+ AE+ +E Q K+ A+R
Sbjct: 1734 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1780
Query: 403 LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQV 462
LR + E + + + E +++ +E RG+ E+ R REL +Q +E+ Q Q+
Sbjct: 1781 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL--AEQELEK-QRQL 1837
Query: 463 HSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR 522
A+G ++RL E+EL +R + EQ +++R + ++ L++E ++
Sbjct: 1838 -----AEGTAQQRL----AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1888
Query: 523 ILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE 567
LE + + K + +E A K + + T+ KS+ LE
Sbjct: 1889 ELEAELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1927
Score = 87.8 bits (216), Expect = 3e-17
Identities = 163/704 (23%), Positives = 291/704 (41%), Gaps = 154/704 (21%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
+E+E R++A+ + L +EL + E + QK L+ E +K A+ + +
Sbjct: 1848 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1907
Query: 64 KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKER-YGKEAGKFSAVSEGQGDP 122
KA+ E S +E + +L ++ FR L E ++ R +EA + ++E
Sbjct: 1908 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1963
Query: 123 PGGPAPTVLAPMPLAEVE---LKWEME--KEEKRLLWEQLQGLESSKQAETSRLQEELAK 177
A VLA A E LK E E +EK E+L+ L + + RL+E+ A+
Sbjct: 1964 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 2023
Query: 178 LSEKLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQ 229
+ +E +L+ ++ + +E+ L+QR++ + + + A K +
Sbjct: 2024 HKADI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 2080
Query: 230 QELEAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNAL 285
ELE +S AE LR + Q E AA R L + + +A+E+V+ L AE A
Sbjct: 2081 LELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2138
Query: 286 RTSLAALEQIQT--AKTQELNMLREQTTGLAAE--------------------------- 316
R AALE+++ AK +E LRE+ +A
Sbjct: 2139 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198
Query: 317 -------LQQQQAEYEDLMGQKDDLNSQLQESLRA----------NSRLLEQLQEIGQEK 359
LQQ+Q+ + L G+ + +E+ A + R +E+ + + Q
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2258
Query: 360 EQLTQELQEARKSAEK----------RKAMLDELAM------------------ETLQEK 391
E+ Q +A+ +AEK R+A ++ A+ +TL++K
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2318
Query: 392 SQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL-------RELH 424
+Q ++EL +RL+ H+K +L R++ E EL EL
Sbjct: 2319 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2378
Query: 425 EDKKRQEEELRGQIREEKARTR-----ELETLQQTVEEL--------------QAQVHSM 465
+ K R E E R I +K T+ E E ++Q EE Q +
Sbjct: 2379 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2438
Query: 466 DGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE 525
+ E+ LKE +E ++ + E Q++++ + L QE K+ + Q E
Sbjct: 2439 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL-QEDKEQMAQQLAEE 2497
Query: 526 KKGSAALKDLKRQLHLERK-RADKLQERLQDILTNSKSRSGLEE 568
+G + +RQ LE A++L+ R+ ++ S++++ EE
Sbjct: 2498 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEM---SRAQARAEE 2538
Score = 82.0 bits (201), Expect = 1e-15
Identities = 115/491 (23%), Positives = 210/491 (42%), Gaps = 59/491 (12%)
Query: 166 AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 225
+ET R EE +L+E+ + ++ RL E E R E Q K +
Sbjct: 1475 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1531
Query: 226 QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 282
Q++Q+E+ ++ + + Q++ E L+ + Q + A+A E+ + E
Sbjct: 1532 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1591
Query: 283 NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 341
+R L A E+ + EL LR + A+ +Q Q E E L Q +D+ + Q
Sbjct: 1592 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1651
Query: 342 LRANSRLLEQLQEIGQEKEQLTQELQEAR----------KSAEKRKAMLDELAMETLQ-- 389
+ SR+ + E +EK++ Q L+E R + AE +A ++A+ET Q
Sbjct: 1652 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1710
Query: 390 -------------------EKSQHKEELGAVRLRHEKE------VLGVRARYERELRELH 424
E+S +E + +LR E E RAR E E REL
Sbjct: 1711 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELE 1769
Query: 425 EDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKE 483
+ + E LR +++ EE A+ + L + ++ +A+ + K E+ +++ E E
Sbjct: 1770 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQRELAE 1828
Query: 484 EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLER 543
+EL+ R E ++R + + L+ E + +++LE ++L R L+R
Sbjct: 1829 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-------EELAR---LQR 1878
Query: 544 KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 603
+ A Q+R + +K R+ +E L+ S+ + +++ S E R +E +
Sbjct: 1879 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE-AEAGRFRELA 1937
Query: 604 AVPARVRGKEE 614
AR+R E
Sbjct: 1938 EEAARLRALAE 1948
Score = 81.6 bits (200), Expect = 2e-15
Identities = 153/612 (25%), Positives = 241/612 (39%), Gaps = 98/612 (16%)
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
K+AQ V L E E +A L Q T A + R +E G+ G+ D
Sbjct: 1250 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD- 1308
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
EVE +W +E L E+ Q + A+T Q EL +L +L
Sbjct: 1309 --------------VEVE-RW---RERVAQLLERWQAV----LAQTDVRQRELEQLGRQL 1346
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKA---QLARTQKLQQELEAANQSL 239
+ +ES L D+R + E++Q AD +A QL + Q L +E+E
Sbjct: 1347 RYYRESADPLGA----WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE------ 1396
Query: 240 AELRDQRQGERLEHAAA-----LRALQD-QVSIQSADAQ-EQVEGLLAENNALRTSLAAL 292
R GE++E + A++D ++ + + AQ E V + S + +
Sbjct: 1397 ------RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1450
Query: 293 EQIQTAKTQ--ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLE 350
++ +T EL L Q +E ++ E E L Q+ + + A
Sbjct: 1451 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1510
Query: 351 QLQEI-GQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEV 409
QL E Q K Q +E +E ++ ++ +E A++ Q+K +EEL +R E E+
Sbjct: 1511 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1570
Query: 410 LG----------VRARYERELRELH---EDKKRQEEELRGQIREEKARTRELET----LQ 452
R R E E+R + E +RQ G+++ +AR E E Q
Sbjct: 1571 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1630
Query: 453 QTVEELQAQVHSMDGAKGWFERRL-----KEAEGKEEE------LQDVRDQLEQAQEERD 501
+ E L+ QV K E L EAE E+ L+++R Q E+A ER
Sbjct: 1631 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERR 1688
Query: 502 CHLKTISSLKQEVKDTVDGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE--- 551
+ +Q QR E K+ S A K L+R L E +L+E
Sbjct: 1689 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1748
Query: 552 -RLQDILTNSKSRSGLE-ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAV 605
R Q ++R E EL ++ + R Q + + S + E ++KE +
Sbjct: 1749 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808
Query: 606 PARVRGKEEPTA 617
AR RGK E A
Sbjct: 1809 EARRRGKAEEQA 1820
Score = 65.5 bits (158), Expect = 1e-10
Identities = 91/442 (20%), Positives = 182/442 (41%), Gaps = 62/442 (14%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKA-----QK 57
QA+ E + +A+LL+ + Q ++ R+ + + Q++A + F + Q+
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2511
Query: 58 ALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSE 117
L S +A+ +++ ++E QA+ + FR Q + + + + K + V
Sbjct: 2512 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQT 2570
Query: 118 GQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQE 173
+ +AE+E + E ++E +LL + + +++ +Q ET LQ+
Sbjct: 2571 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2630
Query: 174 ELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELE 233
+ L +++ + + + E LF D K ++L++ + Q+ QQ++E
Sbjct: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQME 2679
Query: 234 AANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALE 293
Q L ++ + + E +R Q+++ ++Q E L EN LR L LE
Sbjct: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2739
Query: 294 Q--------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ 339
+ Q A T+ L R+ G AAE + + + D L ++
Sbjct: 2740 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS 2791
Query: 340 ESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEEL 398
++LQE G + Q L + + +DELA E ++ Q + +
Sbjct: 2792 ---------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSI 2835
Query: 399 GAVRLRHEKEVLGVRARYEREL 420
+ L+ E L V A +R+L
Sbjct: 2836 AGLLLKATNEKLSVYAALQRQL 2857
Score = 40.0 bits (92), Expect = 0.006
Identities = 87/388 (22%), Positives = 155/388 (39%), Gaps = 40/388 (10%)
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQ-SLAE 241
++ QE+ RL+ + + L L + D K+ LA Q L+++++ SLA
Sbjct: 1000 QEAQEAVTRLEAQHQALVT--------LWHQLHVDMKSLLA-WQSLRRDVQLIRSWSLAT 1050
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + E+ + AL +L+ D+Q+ A L A + +
Sbjct: 1051 FRTLKPEEQRQ---ALHSLELHYQAFLRDSQD------AGGFGPEDRLMAEREYGSCSHH 1101
Query: 302 ELNMLREQTTGLAAELQQQQ--AEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEK 359
+L+ G E + Q+ +E +D+ Q + ++ LR L +E +E
Sbjct: 1102 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR-----LPLDKEPAREC 1156
Query: 360 EQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE 419
Q E Q+A+ E + L+ E + + + A LR E E+ + R
Sbjct: 1157 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1216
Query: 420 LRELHEDK-KRQEEELRG-QIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
L ++ +K K +RG Q EE R E E L++ + + A + ++ K ++
Sbjct: 1217 LSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEA-QAVPATLPELEATKASLKKLRA 1274
Query: 478 EAEGKEEELQDVRDQLEQAQE----------ERDCHLKTISSLKQEVKDTVDGQRILEKK 527
+AE ++ +RD+L AQE ERD ++ ++ +
Sbjct: 1275 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1334
Query: 528 GSAALKDLKRQLHLERKRADKLQERLQD 555
L+ L RQL R+ AD L LQD
Sbjct: 1335 RQRELEQLGRQLRYYRESADPLGAWLQD 1362
Score = 38.9 bits (89), Expect = 0.014
Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)
Query: 133 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 189
P EVE + RLL+ +Q L+ + + ++ + +L E+L + +
Sbjct: 569 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 628
Query: 190 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 225
R + E TL D +EE Q R + A+ L
Sbjct: 629 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 688
Query: 226 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 285
+ +QS+ E R + + R + A + Q LL + A
Sbjct: 689 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 748
Query: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 345
SL +L A T+EL L E+ E+ ++ M K + S L L
Sbjct: 749 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 805
Query: 346 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 405
+ +++LQ G ++L +E AR + E +A LQ + +L H
Sbjct: 806 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 854
Query: 406 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 464
KE ++ ++RE ++ +E LR + + A LE L Q ++ + Q++
Sbjct: 855 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 913
Query: 465 MDGAKGWFERRLK 477
G +R K
Sbjct: 914 YKGHLSGLAKRAK 926
Score = 35.0 bits (79), Expect = 0.21
Identities = 50/233 (21%), Positives = 104/233 (44%), Gaps = 26/233 (11%)
Query: 165 QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 223
+A+ R + + +LS + ++ RL + L N S+ ++ L E+ H A
Sbjct: 706 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 761
Query: 224 RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 279
T++L ++E E ++ ++ ++A +R L+ + + + Q + LL
Sbjct: 762 ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 820
Query: 280 AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 336
E++ R ++ E Q A + + + + + A L++ A ++ D+ + L
Sbjct: 821 REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 876
Query: 337 QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML 380
+LQE+LR +RL + LQ+ EKEQL + A++ KA++
Sbjct: 877 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 929
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 99.4 bits (246), Expect = 9e-21
Identities = 131/550 (23%), Positives = 237/550 (43%), Gaps = 78/550 (14%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
L EEE R+Q + +L EL K E+ L A ++E ++ KSK+
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRSTSEKSKQ 1765
Query: 65 AQEVEV-LLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE---AGKFSAVSEGQG 120
E E E A+L + E+ + Q + +++R E A K +A+ E
Sbjct: 1766 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA-- 1823
Query: 121 DPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE 180
++ + E+ +EK E+L+ L + + RL+E+ A+
Sbjct: 1824 ----------------TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1867
Query: 181 KLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQQEL 232
+ +E +L+ ++ + +E+ L+QR++ + + + A K + EL
Sbjct: 1868 DI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1924
Query: 233 EAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNALRTS 288
E +S AE LR + Q E AA R L + + +A+E+V+ L AE A R
Sbjct: 1925 ELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 1982
Query: 289 LAALEQIQ--TAKTQELNMLREQTTGLAAELQQ--QQAEYEDLMGQK-------DDLNSQ 337
AALE+++ AK +E LRE+ +A Q Q+A + L ++ +
Sbjct: 1983 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2042
Query: 338 LQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEE 397
LQ++L+ +L+QL+ + + +E +EAR AE+ E Q + Q +E
Sbjct: 2043 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----------EAAQSRRQVEE- 2091
Query: 398 LGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEE 457
A RL+ E E + + E+LR + +E AR + E Q + +
Sbjct: 2092 --AERLKQSAE----------EQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQ 2137
Query: 458 LQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDT 517
QA M+ K + E+ L++ E+EL +R QLE+ +++ + + LK E +
Sbjct: 2138 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2197
Query: 518 VDGQRILEKK 527
+ +E++
Sbjct: 2198 ARQRSQVEEE 2207
Score = 94.0 bits (232), Expect = 4e-19
Identities = 140/621 (22%), Positives = 252/621 (40%), Gaps = 43/621 (6%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA 65
+E E Q ++A+ E Q +E + LR++V + +A+ L+ KA
Sbjct: 1449 AEGELQALRARAEEAEAQKRQAQEEAER-------LRRQVQDESQRKRQAEVELASRVKA 1501
Query: 66 QEVEVLLSENEMLQA----KLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGD 121
E E + LQA +L ++E + RL+ + + + + E + SA +E Q
Sbjct: 1502 -EAEAAREKQRALQALEELRLQAEEAERRLRQAEV-ERARQVQVALETAQRSAEAELQSK 1559
Query: 122 PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 181
T L E + +EE +Q QAE R +EE + E+
Sbjct: 1560 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELER 1611
Query: 182 LKKKQESFCRLQTEKETLFND-SRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLA 240
+ K RL+ + E + S + E +Q++EA+ +A R + +E + LA
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA---RRRGKAEEQAVRQRELA 1668
Query: 241 ELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT 300
E ++Q + E A R +Q I+ EQ E + L LA L++ A T
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREAAAAT 1725
Query: 301 QELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE 360
Q+ L + + AE++ A + + + ++ L A + +L E
Sbjct: 1726 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1785
Query: 361 QLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE- 419
L +E + R+ AE+ A A L EK E A RL+ E E+ E E
Sbjct: 1786 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENER 1843
Query: 420 LRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEA 479
LR L ED+ Q L Q + KA E + + +A ++ KG E L++
Sbjct: 1844 LRRLAEDEAFQRRRLEEQAAQHKADIEE-----RLAQLRKASDSELERQKGLVEDTLRQR 1898
Query: 480 EGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 539
EEE+ ++ E+A + + ++ +DT+ + E + + +RQL
Sbjct: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-----QRQL 1953
Query: 540 HL-ERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 598
E +R + +ER+Q L + + + L E+ + + ++ + + +E R
Sbjct: 1954 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRLRERAEQESAR 2012
Query: 599 EKESSAVPARVRGKEEPTAPA 619
+ + + A+ R + E A A
Sbjct: 2013 QLQLAQEAAQKRLQAEEKAHA 2033
Score = 94.0 bits (232), Expect = 4e-19
Identities = 134/579 (23%), Positives = 249/579 (43%), Gaps = 58/579 (10%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
+A E+E ++ QL E L +EL++ E T ++ + +++E
Sbjct: 2159 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-------- 2210
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
V V + E L+A++ ++ L++ F +E EA K V+E +
Sbjct: 2211 -----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE----EAEKMKQVAE-EAAR 2260
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
A LAE +L + EK +L E++Q ++ E +RL+ E L ++
Sbjct: 2261 LSVAAQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQK 2314
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAE 241
+ QE RLQ +KE + + + Q+ EA+ + QL + + ++ +L A S A+
Sbjct: 2315 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2374
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + +R A + +++ QE+V T + LE +
Sbjct: 2375 ARAEEDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDH 2421
Query: 302 ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQ 361
+ LRE L E ++ Q E + L + +++ + QE L ++ L+Q EK+
Sbjct: 2422 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--SFLSEKDS 2479
Query: 362 LTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELR 421
L Q + E+ KA L++L + + + Q +EE + + E+E + A E R
Sbjct: 2480 LLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535
Query: 422 ELHEDK---KRQEEELRGQIREEKARTREL--ETLQQTVEELQAQVHSMDGAKGWFERRL 476
HE + +R++EEL+ Q+ +++ + EL E Q+ E+LQ A E
Sbjct: 2536 RQHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2594
Query: 477 KEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK 536
+ L + RD L+ E + + L+++ V QR L++ G + ++L+
Sbjct: 2595 ASQVAATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VSAQR-LQEAGILSAEELQ 2648
Query: 537 RQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 575
R L D+L R +D+ + RS + L+L N
Sbjct: 2649 R-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2685
Score = 92.0 bits (227), Expect = 1e-18
Identities = 117/505 (23%), Positives = 213/505 (42%), Gaps = 43/505 (8%)
Query: 1 MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
+ Q+ E+ R QAQ + + R+ E +LRQK A D E K +K
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2153
Query: 61 KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQG 120
++ + Q+ +V E E+ +L +E D + + K + A + S V E
Sbjct: 2154 QTLR-QKAQV---EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--- 2206
Query: 121 DPPGGPAPTVLAPMPLAEV-ELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLS 179
+ + E+ +LK +E E + L+ + Q E ++++ + +
Sbjct: 2207 -------ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2259
Query: 180 EKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQ--LARTQKLQQELEAANQ 237
QE+ Q +E L + L+++ +A +A A + LQQ+ E A +
Sbjct: 2260 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2319
Query: 238 SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQT 297
L++ ++ + A + Q + A+ Q Q+E + AE L+ +A + + Q
Sbjct: 2320 QARRLQEDKEQMAQQLAEETQGFQRTL---EAERQRQLE-MSAEAERLKLRVAEMSRAQA 2375
Query: 298 AKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ 357
++ R+Q + +L + + ++ + L Q Q+S RL E + E+ +
Sbjct: 2376 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2435
Query: 358 EKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYE 417
EKE+L QE + + +E+ + + E ++ Q Q EK+ L R R+
Sbjct: 2436 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--------SFLSEKDSLLQRERFI 2487
Query: 418 RELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
+ + E + E Q+REE+ R + QQ +E Q V SM+ A+ RR
Sbjct: 2488 EQEKAKLEQLFQDEVAKAQQLREEQQRQQ-----QQMEQERQRLVASMEEAR----RRQH 2538
Query: 478 EAE----GKEEELQDVRDQLEQAQE 498
EAE K+EELQ + Q Q +E
Sbjct: 2539 EAEEGVRRKQEELQQLEQQRRQQEE 2563
Score = 88.6 bits (218), Expect = 2e-17
Identities = 107/465 (23%), Positives = 194/465 (41%), Gaps = 69/465 (14%)
Query: 136 LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 195
LAEVE E +++ + E + R+QEE+ + E Q+ +Q E
Sbjct: 1340 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1399
Query: 196 KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 255
+ L S +I+ ++ EA +++L ++++E+ L QR G E
Sbjct: 1400 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1454
Query: 256 ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 293
ALRA ++ Q AQE+ E L AE A R AL+
Sbjct: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514
Query: 294 QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 342
++ + Q E+ R+ L + +AE + + +QL+ SL
Sbjct: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
Query: 343 RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 402
+ + QL+E + + Q E + AR+ AE+ +E Q K+ A+R
Sbjct: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1621
Query: 403 LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQV 462
LR + E + + + E +++ +E RG+ E+ R REL +Q +E+ Q Q+
Sbjct: 1622 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL--AEQELEK-QRQL 1678
Query: 463 HSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR 522
A+G ++RL E+EL +R + EQ +++R + ++ L++E ++
Sbjct: 1679 -----AEGTAQQRL----AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1729
Query: 523 ILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE 567
LE + + K + +E A K + + T+ KS+ LE
Sbjct: 1730 ELEAELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1768
Score = 87.8 bits (216), Expect = 3e-17
Identities = 163/704 (23%), Positives = 291/704 (41%), Gaps = 154/704 (21%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
+E+E R++A+ + L +EL + E + QK L+ E +K A+ + +
Sbjct: 1689 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1748
Query: 64 KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKER-YGKEAGKFSAVSEGQGDP 122
KA+ E S +E + +L ++ FR L E ++ R +EA + ++E
Sbjct: 1749 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1804
Query: 123 PGGPAPTVLAPMPLAEVE---LKWEME--KEEKRLLWEQLQGLESSKQAETSRLQEELAK 177
A VLA A E LK E E +EK E+L+ L + + RL+E+ A+
Sbjct: 1805 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1864
Query: 178 LSEKLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQ 229
+ +E +L+ ++ + +E+ L+QR++ + + + A K +
Sbjct: 1865 HKADI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1921
Query: 230 QELEAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNAL 285
ELE +S AE LR + Q E AA R L + + +A+E+V+ L AE A
Sbjct: 1922 LELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1979
Query: 286 RTSLAALEQIQT--AKTQELNMLREQTTGLAAE--------------------------- 316
R AALE+++ AK +E LRE+ +A
Sbjct: 1980 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039
Query: 317 -------LQQQQAEYEDLMGQKDDLNSQLQESLRA----------NSRLLEQLQEIGQEK 359
LQQ+Q+ + L G+ + +E+ A + R +E+ + + Q
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2099
Query: 360 EQLTQELQEARKSAEK----------RKAMLDELAM------------------ETLQEK 391
E+ Q +A+ +AEK R+A ++ A+ +TL++K
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2159
Query: 392 SQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL-------RELH 424
+Q ++EL +RL+ H+K +L R++ E EL EL
Sbjct: 2160 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2219
Query: 425 EDKKRQEEELRGQIREEKARTR-----ELETLQQTVEEL--------------QAQVHSM 465
+ K R E E R I +K T+ E E ++Q EE Q +
Sbjct: 2220 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2279
Query: 466 DGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE 525
+ E+ LKE +E ++ + E Q++++ + L QE K+ + Q E
Sbjct: 2280 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL-QEDKEQMAQQLAEE 2338
Query: 526 KKGSAALKDLKRQLHLERK-RADKLQERLQDILTNSKSRSGLEE 568
+G + +RQ LE A++L+ R+ ++ S++++ EE
Sbjct: 2339 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEM---SRAQARAEE 2379
Score = 82.0 bits (201), Expect = 1e-15
Identities = 115/491 (23%), Positives = 210/491 (42%), Gaps = 59/491 (12%)
Query: 166 AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 225
+ET R EE +L+E+ + ++ RL E E R E Q K +
Sbjct: 1316 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1372
Query: 226 QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 282
Q++Q+E+ ++ + + Q++ E L+ + Q + A+A E+ + E
Sbjct: 1373 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1432
Query: 283 NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 341
+R L A E+ + EL LR + A+ +Q Q E E L Q +D+ + Q
Sbjct: 1433 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1492
Query: 342 LRANSRLLEQLQEIGQEKEQLTQELQEAR----------KSAEKRKAMLDELAMETLQ-- 389
+ SR+ + E +EK++ Q L+E R + AE +A ++A+ET Q
Sbjct: 1493 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1551
Query: 390 -------------------EKSQHKEELGAVRLRHEKE------VLGVRARYERELRELH 424
E+S +E + +LR E E RAR E E REL
Sbjct: 1552 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELE 1610
Query: 425 EDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKE 483
+ + E LR +++ EE A+ + L + ++ +A+ + K E+ +++ E E
Sbjct: 1611 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQRELAE 1669
Query: 484 EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLER 543
+EL+ R E ++R + + L+ E + +++LE ++L R L+R
Sbjct: 1670 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-------EELAR---LQR 1719
Query: 544 KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 603
+ A Q+R + +K R+ +E L+ S+ + +++ S E R +E +
Sbjct: 1720 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE-AEAGRFRELA 1778
Query: 604 AVPARVRGKEE 614
AR+R E
Sbjct: 1779 EEAARLRALAE 1789
Score = 81.6 bits (200), Expect = 2e-15
Identities = 153/612 (25%), Positives = 241/612 (39%), Gaps = 98/612 (16%)
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
K+AQ V L E E +A L Q T A + R +E G+ G+ D
Sbjct: 1091 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD- 1149
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
EVE +W +E L E+ Q + A+T Q EL +L +L
Sbjct: 1150 --------------VEVE-RW---RERVAQLLERWQAV----LAQTDVRQRELEQLGRQL 1187
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKA---QLARTQKLQQELEAANQSL 239
+ +ES L D+R + E++Q AD +A QL + Q L +E+E
Sbjct: 1188 RYYRESADPLGA----WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE------ 1237
Query: 240 AELRDQRQGERLEHAAA-----LRALQD-QVSIQSADAQ-EQVEGLLAENNALRTSLAAL 292
R GE++E + A++D ++ + + AQ E V + S + +
Sbjct: 1238 ------RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1291
Query: 293 EQIQTAKTQ--ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLE 350
++ +T EL L Q +E ++ E E L Q+ + + A
Sbjct: 1292 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1351
Query: 351 QLQEI-GQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEV 409
QL E Q K Q +E +E ++ ++ +E A++ Q+K +EEL +R E E+
Sbjct: 1352 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1411
Query: 410 LG----------VRARYERELRELH---EDKKRQEEELRGQIREEKARTRELET----LQ 452
R R E E+R + E +RQ G+++ +AR E E Q
Sbjct: 1412 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1471
Query: 453 QTVEELQAQVHSMDGAKGWFERRL-----KEAEGKEEE------LQDVRDQLEQAQEERD 501
+ E L+ QV K E L EAE E+ L+++R Q E+A ER
Sbjct: 1472 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERR 1529
Query: 502 CHLKTISSLKQEVKDTVDGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE--- 551
+ +Q QR E K+ S A K L+R L E +L+E
Sbjct: 1530 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1589
Query: 552 -RLQDILTNSKSRSGLE-ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAV 605
R Q ++R E EL ++ + R Q + + S + E ++KE +
Sbjct: 1590 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649
Query: 606 PARVRGKEEPTA 617
AR RGK E A
Sbjct: 1650 EARRRGKAEEQA 1661
Score = 65.5 bits (158), Expect = 1e-10
Identities = 91/442 (20%), Positives = 182/442 (41%), Gaps = 62/442 (14%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKA-----QK 57
QA+ E + +A+LL+ + Q ++ R+ + + Q++A + F + Q+
Sbjct: 2295 QAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2352
Query: 58 ALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSE 117
L S +A+ +++ ++E QA+ + FR Q + + + + K + V
Sbjct: 2353 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQT 2411
Query: 118 GQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQE 173
+ +AE+E + E ++E +LL + + +++ +Q ET LQ+
Sbjct: 2412 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2471
Query: 174 ELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELE 233
+ L +++ + + + E LF D K ++L++ + Q+ QQ++E
Sbjct: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQME 2520
Query: 234 AANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALE 293
Q L ++ + + E +R Q+++ ++Q E L EN LR L LE
Sbjct: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2580
Query: 294 Q--------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ 339
+ Q A T+ L R+ G AAE + + + D L ++
Sbjct: 2581 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS 2632
Query: 340 ESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEEL 398
++LQE G + Q L + + +DELA E ++ Q + +
Sbjct: 2633 ---------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSI 2676
Query: 399 GAVRLRHEKEVLGVRARYEREL 420
+ L+ E L V A +R+L
Sbjct: 2677 AGLLLKATNEKLSVYAALQRQL 2698
Score = 40.0 bits (92), Expect = 0.006
Identities = 87/388 (22%), Positives = 155/388 (39%), Gaps = 40/388 (10%)
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQ-SLAE 241
++ QE+ RL+ + + L L + D K+ LA Q L+++++ SLA
Sbjct: 841 QEAQEAVTRLEAQHQALVT--------LWHQLHVDMKSLLA-WQSLRRDVQLIRSWSLAT 891
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + E+ + AL +L+ D+Q+ A L A + +
Sbjct: 892 FRTLKPEEQRQ---ALHSLELHYQAFLRDSQD------AGGFGPEDRLMAEREYGSCSHH 942
Query: 302 ELNMLREQTTGLAAELQQQQ--AEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEK 359
+L+ G E + Q+ +E +D+ Q + ++ LR L +E +E
Sbjct: 943 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR-----LPLDKEPAREC 997
Query: 360 EQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE 419
Q E Q+A+ E + L+ E + + + A LR E E+ + R
Sbjct: 998 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1057
Query: 420 LRELHEDK-KRQEEELRG-QIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
L ++ +K K +RG Q EE R E E L++ + + A + ++ K ++
Sbjct: 1058 LSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEA-QAVPATLPELEATKASLKKLRA 1115
Query: 478 EAEGKEEELQDVRDQLEQAQE----------ERDCHLKTISSLKQEVKDTVDGQRILEKK 527
+AE ++ +RD+L AQE ERD ++ ++ +
Sbjct: 1116 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1175
Query: 528 GSAALKDLKRQLHLERKRADKLQERLQD 555
L+ L RQL R+ AD L LQD
Sbjct: 1176 RQRELEQLGRQLRYYRESADPLGAWLQD 1203
Score = 38.9 bits (89), Expect = 0.014
Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)
Query: 133 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 189
P EVE + RLL+ +Q L+ + + ++ + +L E+L + +
Sbjct: 410 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 469
Query: 190 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 225
R + E TL D +EE Q R + A+ L
Sbjct: 470 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 529
Query: 226 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 285
+ +QS+ E R + + R + A + Q LL + A
Sbjct: 530 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 589
Query: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 345
SL +L A T+EL L E+ E+ ++ M K + S L L
Sbjct: 590 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 646
Query: 346 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 405
+ +++LQ G ++L +E AR + E +A LQ + +L H
Sbjct: 647 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 695
Query: 406 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 464
KE ++ ++RE ++ +E LR + + A LE L Q ++ + Q++
Sbjct: 696 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 754
Query: 465 MDGAKGWFERRLK 477
G +R K
Sbjct: 755 YKGHLSGLAKRAK 767
Score = 35.0 bits (79), Expect = 0.21
Identities = 50/233 (21%), Positives = 104/233 (44%), Gaps = 26/233 (11%)
Query: 165 QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 223
+A+ R + + +LS + ++ RL + L N S+ ++ L E+ H A
Sbjct: 547 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 602
Query: 224 RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 279
T++L ++E E ++ ++ ++A +R L+ + + + Q + LL
Sbjct: 603 ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 661
Query: 280 AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 336
E++ R ++ E Q A + + + + + A L++ A ++ D+ + L
Sbjct: 662 REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 717
Query: 337 QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML 380
+LQE+LR +RL + LQ+ EKEQL + A++ KA++
Sbjct: 718 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 770
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 99.4 bits (246), Expect = 9e-21
Identities = 131/550 (23%), Positives = 237/550 (43%), Gaps = 78/550 (14%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
L EEE R+Q + +L EL K E+ L A ++E ++ KSK+
Sbjct: 1717 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRSTSEKSKQ 1773
Query: 65 AQEVEV-LLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE---AGKFSAVSEGQG 120
E E E A+L + E+ + Q + +++R E A K +A+ E
Sbjct: 1774 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA-- 1831
Query: 121 DPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE 180
++ + E+ +EK E+L+ L + + RL+E+ A+
Sbjct: 1832 ----------------TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1875
Query: 181 KLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQQEL 232
+ +E +L+ ++ + +E+ L+QR++ + + + A K + EL
Sbjct: 1876 DI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1932
Query: 233 EAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNALRTS 288
E +S AE LR + Q E AA R L + + +A+E+V+ L AE A R
Sbjct: 1933 ELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 1990
Query: 289 LAALEQIQ--TAKTQELNMLREQTTGLAAELQQ--QQAEYEDLMGQK-------DDLNSQ 337
AALE+++ AK +E LRE+ +A Q Q+A + L ++ +
Sbjct: 1991 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2050
Query: 338 LQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEE 397
LQ++L+ +L+QL+ + + +E +EAR AE+ E Q + Q +E
Sbjct: 2051 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----------EAAQSRRQVEE- 2099
Query: 398 LGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEE 457
A RL+ E E + + E+LR + +E AR + E Q + +
Sbjct: 2100 --AERLKQSAE----------EQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQ 2145
Query: 458 LQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDT 517
QA M+ K + E+ L++ E+EL +R QLE+ +++ + + LK E +
Sbjct: 2146 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2205
Query: 518 VDGQRILEKK 527
+ +E++
Sbjct: 2206 ARQRSQVEEE 2215
Score = 94.0 bits (232), Expect = 4e-19
Identities = 140/621 (22%), Positives = 252/621 (40%), Gaps = 43/621 (6%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA 65
+E E Q ++A+ E Q +E + LR++V + +A+ L+ KA
Sbjct: 1457 AEGELQALRARAEEAEAQKRQAQEEAER-------LRRQVQDESQRKRQAEVELASRVKA 1509
Query: 66 QEVEVLLSENEMLQA----KLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGD 121
E E + LQA +L ++E + RL+ + + + + E + SA +E Q
Sbjct: 1510 -EAEAAREKQRALQALEELRLQAEEAERRLRQAEV-ERARQVQVALETAQRSAEAELQSK 1567
Query: 122 PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 181
T L E + +EE +Q QAE R +EE + E+
Sbjct: 1568 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELER 1619
Query: 182 LKKKQESFCRLQTEKETLFND-SRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLA 240
+ K RL+ + E + S + E +Q++EA+ +A R + +E + LA
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA---RRRGKAEEQAVRQRELA 1676
Query: 241 ELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT 300
E ++Q + E A R +Q I+ EQ E + L LA L++ A T
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREAAAAT 1733
Query: 301 QELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE 360
Q+ L + + AE++ A + + + ++ L A + +L E
Sbjct: 1734 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1793
Query: 361 QLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE- 419
L +E + R+ AE+ A A L EK E A RL+ E E+ E E
Sbjct: 1794 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENER 1851
Query: 420 LRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEA 479
LR L ED+ Q L Q + KA E + + +A ++ KG E L++
Sbjct: 1852 LRRLAEDEAFQRRRLEEQAAQHKADIEE-----RLAQLRKASDSELERQKGLVEDTLRQR 1906
Query: 480 EGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 539
EEE+ ++ E+A + + ++ +DT+ + E + + +RQL
Sbjct: 1907 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-----QRQL 1961
Query: 540 HL-ERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 598
E +R + +ER+Q L + + + L E+ + + ++ + + +E R
Sbjct: 1962 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRLRERAEQESAR 2020
Query: 599 EKESSAVPARVRGKEEPTAPA 619
+ + + A+ R + E A A
Sbjct: 2021 QLQLAQEAAQKRLQAEEKAHA 2041
Score = 94.0 bits (232), Expect = 4e-19
Identities = 134/579 (23%), Positives = 249/579 (43%), Gaps = 58/579 (10%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
+A E+E ++ QL E L +EL++ E T ++ + +++E
Sbjct: 2167 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-------- 2218
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
V V + E L+A++ ++ L++ F +E EA K V+E +
Sbjct: 2219 -----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE----EAEKMKQVAE-EAAR 2268
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
A LAE +L + EK +L E++Q ++ E +RL+ E L ++
Sbjct: 2269 LSVAAQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQK 2322
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAE 241
+ QE RLQ +KE + + + Q+ EA+ + QL + + ++ +L A S A+
Sbjct: 2323 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2382
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + +R A + +++ QE+V T + LE +
Sbjct: 2383 ARAEEDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDH 2429
Query: 302 ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQ 361
+ LRE L E ++ Q E + L + +++ + QE L ++ L+Q EK+
Sbjct: 2430 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--SFLSEKDS 2487
Query: 362 LTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELR 421
L Q + E+ KA L++L + + + Q +EE + + E+E + A E R
Sbjct: 2488 LLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2543
Query: 422 ELHEDK---KRQEEELRGQIREEKARTREL--ETLQQTVEELQAQVHSMDGAKGWFERRL 476
HE + +R++EEL+ Q+ +++ + EL E Q+ E+LQ A E
Sbjct: 2544 RQHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2602
Query: 477 KEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK 536
+ L + RD L+ E + + L+++ V QR L++ G + ++L+
Sbjct: 2603 ASQVAATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VSAQR-LQEAGILSAEELQ 2656
Query: 537 RQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 575
R L D+L R +D+ + RS + L+L N
Sbjct: 2657 R-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2693
Score = 92.0 bits (227), Expect = 1e-18
Identities = 117/505 (23%), Positives = 213/505 (42%), Gaps = 43/505 (8%)
Query: 1 MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
+ Q+ E+ R QAQ + + R+ E +LRQK A D E K +K
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2161
Query: 61 KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQG 120
++ + Q+ +V E E+ +L +E D + + K + A + S V E
Sbjct: 2162 QTLR-QKAQV---EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--- 2214
Query: 121 DPPGGPAPTVLAPMPLAEV-ELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLS 179
+ + E+ +LK +E E + L+ + Q E ++++ + +
Sbjct: 2215 -------ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2267
Query: 180 EKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQ--LARTQKLQQELEAANQ 237
QE+ Q +E L + L+++ +A +A A + LQQ+ E A +
Sbjct: 2268 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2327
Query: 238 SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQT 297
L++ ++ + A + Q + A+ Q Q+E + AE L+ +A + + Q
Sbjct: 2328 QARRLQEDKEQMAQQLAEETQGFQRTL---EAERQRQLE-MSAEAERLKLRVAEMSRAQA 2383
Query: 298 AKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ 357
++ R+Q + +L + + ++ + L Q Q+S RL E + E+ +
Sbjct: 2384 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2443
Query: 358 EKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYE 417
EKE+L QE + + +E+ + + E ++ Q Q EK+ L R R+
Sbjct: 2444 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--------SFLSEKDSLLQRERFI 2495
Query: 418 RELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
+ + E + E Q+REE+ R + QQ +E Q V SM+ A+ RR
Sbjct: 2496 EQEKAKLEQLFQDEVAKAQQLREEQQRQQ-----QQMEQERQRLVASMEEAR----RRQH 2546
Query: 478 EAE----GKEEELQDVRDQLEQAQE 498
EAE K+EELQ + Q Q +E
Sbjct: 2547 EAEEGVRRKQEELQQLEQQRRQQEE 2571
Score = 88.6 bits (218), Expect = 2e-17
Identities = 107/465 (23%), Positives = 194/465 (41%), Gaps = 69/465 (14%)
Query: 136 LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 195
LAEVE E +++ + E + R+QEE+ + E Q+ +Q E
Sbjct: 1348 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1407
Query: 196 KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 255
+ L S +I+ ++ EA +++L ++++E+ L QR G E
Sbjct: 1408 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1462
Query: 256 ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 293
ALRA ++ Q AQE+ E L AE A R AL+
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1522
Query: 294 QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 342
++ + Q E+ R+ L + +AE + + +QL+ SL
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582
Query: 343 RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 402
+ + QL+E + + Q E + AR+ AE+ +E Q K+ A+R
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1629
Query: 403 LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQV 462
LR + E + + + E +++ +E RG+ E+ R REL +Q +E+ Q Q+
Sbjct: 1630 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL--AEQELEK-QRQL 1686
Query: 463 HSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR 522
A+G ++RL E+EL +R + EQ +++R + ++ L++E ++
Sbjct: 1687 -----AEGTAQQRL----AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1737
Query: 523 ILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE 567
LE + + K + +E A K + + T+ KS+ LE
Sbjct: 1738 ELEAELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1776
Score = 87.8 bits (216), Expect = 3e-17
Identities = 163/704 (23%), Positives = 291/704 (41%), Gaps = 154/704 (21%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
+E+E R++A+ + L +EL + E + QK L+ E +K A+ + +
Sbjct: 1697 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1756
Query: 64 KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKER-YGKEAGKFSAVSEGQGDP 122
KA+ E S +E + +L ++ FR L E ++ R +EA + ++E
Sbjct: 1757 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1812
Query: 123 PGGPAPTVLAPMPLAEVE---LKWEME--KEEKRLLWEQLQGLESSKQAETSRLQEELAK 177
A VLA A E LK E E +EK E+L+ L + + RL+E+ A+
Sbjct: 1813 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1872
Query: 178 LSEKLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQ 229
+ +E +L+ ++ + +E+ L+QR++ + + + A K +
Sbjct: 1873 HKADI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1929
Query: 230 QELEAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNAL 285
ELE +S AE LR + Q E AA R L + + +A+E+V+ L AE A
Sbjct: 1930 LELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1987
Query: 286 RTSLAALEQIQT--AKTQELNMLREQTTGLAAE--------------------------- 316
R AALE+++ AK +E LRE+ +A
Sbjct: 1988 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047
Query: 317 -------LQQQQAEYEDLMGQKDDLNSQLQESLRA----------NSRLLEQLQEIGQEK 359
LQQ+Q+ + L G+ + +E+ A + R +E+ + + Q
Sbjct: 2048 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2107
Query: 360 EQLTQELQEARKSAEK----------RKAMLDELAM------------------ETLQEK 391
E+ Q +A+ +AEK R+A ++ A+ +TL++K
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2167
Query: 392 SQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL-------RELH 424
+Q ++EL +RL+ H+K +L R++ E EL EL
Sbjct: 2168 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2227
Query: 425 EDKKRQEEELRGQIREEKARTR-----ELETLQQTVEEL--------------QAQVHSM 465
+ K R E E R I +K T+ E E ++Q EE Q +
Sbjct: 2228 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2287
Query: 466 DGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE 525
+ E+ LKE +E ++ + E Q++++ + L QE K+ + Q E
Sbjct: 2288 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL-QEDKEQMAQQLAEE 2346
Query: 526 KKGSAALKDLKRQLHLERK-RADKLQERLQDILTNSKSRSGLEE 568
+G + +RQ LE A++L+ R+ ++ S++++ EE
Sbjct: 2347 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEM---SRAQARAEE 2387
Score = 82.0 bits (201), Expect = 1e-15
Identities = 115/491 (23%), Positives = 210/491 (42%), Gaps = 59/491 (12%)
Query: 166 AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 225
+ET R EE +L+E+ + ++ RL E E R E Q K +
Sbjct: 1324 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1380
Query: 226 QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 282
Q++Q+E+ ++ + + Q++ E L+ + Q + A+A E+ + E
Sbjct: 1381 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1440
Query: 283 NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 341
+R L A E+ + EL LR + A+ +Q Q E E L Q +D+ + Q
Sbjct: 1441 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1500
Query: 342 LRANSRLLEQLQEIGQEKEQLTQELQEAR----------KSAEKRKAMLDELAMETLQ-- 389
+ SR+ + E +EK++ Q L+E R + AE +A ++A+ET Q
Sbjct: 1501 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1559
Query: 390 -------------------EKSQHKEELGAVRLRHEKE------VLGVRARYERELRELH 424
E+S +E + +LR E E RAR E E REL
Sbjct: 1560 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELE 1618
Query: 425 EDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKE 483
+ + E LR +++ EE A+ + L + ++ +A+ + K E+ +++ E E
Sbjct: 1619 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQRELAE 1677
Query: 484 EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLER 543
+EL+ R E ++R + + L+ E + +++LE ++L R L+R
Sbjct: 1678 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-------EELAR---LQR 1727
Query: 544 KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 603
+ A Q+R + +K R+ +E L+ S+ + +++ S E R +E +
Sbjct: 1728 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE-AEAGRFRELA 1786
Query: 604 AVPARVRGKEE 614
AR+R E
Sbjct: 1787 EEAARLRALAE 1797
Score = 81.6 bits (200), Expect = 2e-15
Identities = 153/612 (25%), Positives = 241/612 (39%), Gaps = 98/612 (16%)
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
K+AQ V L E E +A L Q T A + R +E G+ G+ D
Sbjct: 1099 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD- 1157
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
EVE +W +E L E+ Q + A+T Q EL +L +L
Sbjct: 1158 --------------VEVE-RW---RERVAQLLERWQAV----LAQTDVRQRELEQLGRQL 1195
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKA---QLARTQKLQQELEAANQSL 239
+ +ES L D+R + E++Q AD +A QL + Q L +E+E
Sbjct: 1196 RYYRESADPLGA----WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE------ 1245
Query: 240 AELRDQRQGERLEHAAA-----LRALQD-QVSIQSADAQ-EQVEGLLAENNALRTSLAAL 292
R GE++E + A++D ++ + + AQ E V + S + +
Sbjct: 1246 ------RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1299
Query: 293 EQIQTAKTQ--ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLE 350
++ +T EL L Q +E ++ E E L Q+ + + A
Sbjct: 1300 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1359
Query: 351 QLQEI-GQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEV 409
QL E Q K Q +E +E ++ ++ +E A++ Q+K +EEL +R E E+
Sbjct: 1360 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1419
Query: 410 LG----------VRARYERELRELH---EDKKRQEEELRGQIREEKARTRELET----LQ 452
R R E E+R + E +RQ G+++ +AR E E Q
Sbjct: 1420 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1479
Query: 453 QTVEELQAQVHSMDGAKGWFERRL-----KEAEGKEEE------LQDVRDQLEQAQEERD 501
+ E L+ QV K E L EAE E+ L+++R Q E+A ER
Sbjct: 1480 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERR 1537
Query: 502 CHLKTISSLKQEVKDTVDGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE--- 551
+ +Q QR E K+ S A K L+R L E +L+E
Sbjct: 1538 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1597
Query: 552 -RLQDILTNSKSRSGLE-ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAV 605
R Q ++R E EL ++ + R Q + + S + E ++KE +
Sbjct: 1598 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1657
Query: 606 PARVRGKEEPTA 617
AR RGK E A
Sbjct: 1658 EARRRGKAEEQA 1669
Score = 65.5 bits (158), Expect = 1e-10
Identities = 91/442 (20%), Positives = 182/442 (41%), Gaps = 62/442 (14%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKA-----QK 57
QA+ E + +A+LL+ + Q ++ R+ + + Q++A + F + Q+
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2360
Query: 58 ALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSE 117
L S +A+ +++ ++E QA+ + FR Q + + + + K + V
Sbjct: 2361 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQT 2419
Query: 118 GQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQE 173
+ +AE+E + E ++E +LL + + +++ +Q ET LQ+
Sbjct: 2420 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2479
Query: 174 ELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELE 233
+ L +++ + + + E LF D K ++L++ + Q+ QQ++E
Sbjct: 2480 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQME 2528
Query: 234 AANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALE 293
Q L ++ + + E +R Q+++ ++Q E L EN LR L LE
Sbjct: 2529 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2588
Query: 294 Q--------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ 339
+ Q A T+ L R+ G AAE + + + D L ++
Sbjct: 2589 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS 2640
Query: 340 ESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEEL 398
++LQE G + Q L + + +DELA E ++ Q + +
Sbjct: 2641 ---------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSI 2684
Query: 399 GAVRLRHEKEVLGVRARYEREL 420
+ L+ E L V A +R+L
Sbjct: 2685 AGLLLKATNEKLSVYAALQRQL 2706
Score = 40.0 bits (92), Expect = 0.006
Identities = 87/388 (22%), Positives = 155/388 (39%), Gaps = 40/388 (10%)
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQ-SLAE 241
++ QE+ RL+ + + L L + D K+ LA Q L+++++ SLA
Sbjct: 849 QEAQEAVTRLEAQHQALVT--------LWHQLHVDMKSLLA-WQSLRRDVQLIRSWSLAT 899
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + E+ + AL +L+ D+Q+ A L A + +
Sbjct: 900 FRTLKPEEQRQ---ALHSLELHYQAFLRDSQD------AGGFGPEDRLMAEREYGSCSHH 950
Query: 302 ELNMLREQTTGLAAELQQQQ--AEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEK 359
+L+ G E + Q+ +E +D+ Q + ++ LR L +E +E
Sbjct: 951 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR-----LPLDKEPAREC 1005
Query: 360 EQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE 419
Q E Q+A+ E + L+ E + + + A LR E E+ + R
Sbjct: 1006 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1065
Query: 420 LRELHEDK-KRQEEELRG-QIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
L ++ +K K +RG Q EE R E E L++ + + A + ++ K ++
Sbjct: 1066 LSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEA-QAVPATLPELEATKASLKKLRA 1123
Query: 478 EAEGKEEELQDVRDQLEQAQE----------ERDCHLKTISSLKQEVKDTVDGQRILEKK 527
+AE ++ +RD+L AQE ERD ++ ++ +
Sbjct: 1124 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1183
Query: 528 GSAALKDLKRQLHLERKRADKLQERLQD 555
L+ L RQL R+ AD L LQD
Sbjct: 1184 RQRELEQLGRQLRYYRESADPLGAWLQD 1211
Score = 38.9 bits (89), Expect = 0.014
Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)
Query: 133 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 189
P EVE + RLL+ +Q L+ + + ++ + +L E+L + +
Sbjct: 418 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 477
Query: 190 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 225
R + E TL D +EE Q R + A+ L
Sbjct: 478 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 537
Query: 226 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 285
+ +QS+ E R + + R + A + Q LL + A
Sbjct: 538 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 597
Query: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 345
SL +L A T+EL L E+ E+ ++ M K + S L L
Sbjct: 598 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 654
Query: 346 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 405
+ +++LQ G ++L +E AR + E +A LQ + +L H
Sbjct: 655 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 703
Query: 406 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 464
KE ++ ++RE ++ +E LR + + A LE L Q ++ + Q++
Sbjct: 704 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 762
Query: 465 MDGAKGWFERRLK 477
G +R K
Sbjct: 763 YKGHLSGLAKRAK 775
Score = 35.0 bits (79), Expect = 0.21
Identities = 50/233 (21%), Positives = 104/233 (44%), Gaps = 26/233 (11%)
Query: 165 QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 223
+A+ R + + +LS + ++ RL + L N S+ ++ L E+ H A
Sbjct: 555 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 610
Query: 224 RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 279
T++L ++E E ++ ++ ++A +R L+ + + + Q + LL
Sbjct: 611 ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 669
Query: 280 AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 336
E++ R ++ E Q A + + + + + A L++ A ++ D+ + L
Sbjct: 670 REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 725
Query: 337 QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML 380
+LQE+LR +RL + LQ+ EKEQL + A++ KA++
Sbjct: 726 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 778
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 99.4 bits (246), Expect = 9e-21
Identities = 131/550 (23%), Positives = 237/550 (43%), Gaps = 78/550 (14%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
L EEE R+Q + +L EL K E+ L A ++E ++ KSK+
Sbjct: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRSTSEKSKQ 1814
Query: 65 AQEVEV-LLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE---AGKFSAVSEGQG 120
E E E A+L + E+ + Q + +++R E A K +A+ E
Sbjct: 1815 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA-- 1872
Query: 121 DPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSE 180
++ + E+ +EK E+L+ L + + RL+E+ A+
Sbjct: 1873 ----------------TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1916
Query: 181 KLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQQEL 232
+ +E +L+ ++ + +E+ L+QR++ + + + A K + EL
Sbjct: 1917 DI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973
Query: 233 EAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNALRTS 288
E +S AE LR + Q E AA R L + + +A+E+V+ L AE A R
Sbjct: 1974 ELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR 2031
Query: 289 LAALEQIQ--TAKTQELNMLREQTTGLAAELQQ--QQAEYEDLMGQK-------DDLNSQ 337
AALE+++ AK +E LRE+ +A Q Q+A + L ++ +
Sbjct: 2032 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2091
Query: 338 LQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEE 397
LQ++L+ +L+QL+ + + +E +EAR AE+ E Q + Q +E
Sbjct: 2092 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----------EAAQSRRQVEE- 2140
Query: 398 LGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEE 457
A RL+ E E + + E+LR + +E AR + E Q + +
Sbjct: 2141 --AERLKQSAE----------EQAQARAQAQAAAEKLRKEAEQEAARRAQAE--QAALRQ 2186
Query: 458 LQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDT 517
QA M+ K + E+ L++ E+EL +R QLE+ +++ + + LK E +
Sbjct: 2187 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2246
Query: 518 VDGQRILEKK 527
+ +E++
Sbjct: 2247 ARQRSQVEEE 2256
Score = 94.0 bits (232), Expect = 4e-19
Identities = 140/621 (22%), Positives = 252/621 (40%), Gaps = 43/621 (6%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKA 65
+E E Q ++A+ E Q +E + LR++V + +A+ L+ KA
Sbjct: 1498 AEGELQALRARAEEAEAQKRQAQEEAER-------LRRQVQDESQRKRQAEVELASRVKA 1550
Query: 66 QEVEVLLSENEMLQA----KLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGD 121
E E + LQA +L ++E + RL+ + + + + E + SA +E Q
Sbjct: 1551 -EAEAAREKQRALQALEELRLQAEEAERRLRQAEV-ERARQVQVALETAQRSAEAELQSK 1608
Query: 122 PPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 181
T L E + +EE +Q QAE R +EE + E+
Sbjct: 1609 RASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ--------QAEAERAREEAERELER 1660
Query: 182 LKKKQESFCRLQTEKETLFND-SRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLA 240
+ K RL+ + E + S + E +Q++EA+ +A R + +E + LA
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREA---RRRGKAEEQAVRQRELA 1717
Query: 241 ELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKT 300
E ++Q + E A R +Q I+ EQ E + L LA L++ A T
Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE---QQRQLLEEELARLQREAAAAT 1774
Query: 301 QELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE 360
Q+ L + + AE++ A + + + ++ L A + +L E
Sbjct: 1775 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1834
Query: 361 QLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE- 419
L +E + R+ AE+ A A L EK E A RL+ E E+ E E
Sbjct: 1835 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGE--ATRLKTEAEIALKEKEAENER 1892
Query: 420 LRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEA 479
LR L ED+ Q L Q + KA E + + +A ++ KG E L++
Sbjct: 1893 LRRLAEDEAFQRRRLEEQAAQHKADIEE-----RLAQLRKASDSELERQKGLVEDTLRQR 1947
Query: 480 EGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 539
EEE+ ++ E+A + + ++ +DT+ + E + + +RQL
Sbjct: 1948 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR-----QRQL 2002
Query: 540 HL-ERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILR 598
E +R + +ER+Q L + + + L E+ + + ++ + + +E R
Sbjct: 2003 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRLRERAEQESAR 2061
Query: 599 EKESSAVPARVRGKEEPTAPA 619
+ + + A+ R + E A A
Sbjct: 2062 QLQLAQEAAQKRLQAEEKAHA 2082
Score = 94.0 bits (232), Expect = 4e-19
Identities = 134/579 (23%), Positives = 249/579 (43%), Gaps = 58/579 (10%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
+A E+E ++ QL E L +EL++ E T ++ + +++E
Sbjct: 2208 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFS-------- 2259
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
V V + E L+A++ ++ L++ F +E EA K V+E +
Sbjct: 2260 -----VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE----EAEKMKQVAE-EAAR 2309
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
A LAE +L + EK +L E++Q ++ E +RL+ E L ++
Sbjct: 2310 LSVAAQEAARLRQLAEEDLAQQRALAEK-MLKEKMQAVQ-----EATRLKAEAELLQQQK 2363
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ-ELEAANQSLAE 241
+ QE RLQ +KE + + + Q+ EA+ + QL + + ++ +L A S A+
Sbjct: 2364 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2423
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + +R A + +++ QE+V T + LE +
Sbjct: 2424 ARAEEDAQRFRKQA--EEIGEKLHRTELATQEKV-----------TLVQTLEIQRQQSDH 2470
Query: 302 ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQ 361
+ LRE L E ++ Q E + L + +++ + QE L ++ L+Q EK+
Sbjct: 2471 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--SFLSEKDS 2528
Query: 362 LTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELR 421
L Q + E+ KA L++L + + + Q +EE + + E+E + A E R
Sbjct: 2529 LLQR----ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2584
Query: 422 ELHEDK---KRQEEELRGQIREEKARTREL--ETLQQTVEELQAQVHSMDGAKGWFERRL 476
HE + +R++EEL+ Q+ +++ + EL E Q+ E+LQ A E
Sbjct: 2585 RQHEAEEGVRRKQEELQ-QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2643
Query: 477 KEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLK 536
+ L + RD L+ E + + L+++ V QR L++ G + ++L+
Sbjct: 2644 ASQVAATKTLPNGRDALDGPAAEAEPE-HSFDGLRRK----VSAQR-LQEAGILSAEELQ 2697
Query: 537 RQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMN 575
R L D+L R +D+ + RS + L+L N
Sbjct: 2698 R-LAQGHTTVDELARR-EDVRHYLQGRSSIAGLLLKATN 2734
Score = 92.0 bits (227), Expect = 1e-18
Identities = 117/505 (23%), Positives = 213/505 (42%), Gaps = 43/505 (8%)
Query: 1 MAQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALS 60
+ Q+ E+ R QAQ + + R+ E +LRQK A D E K +K
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA-ADAEMEKHKKFAE 2202
Query: 61 KSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQG 120
++ + Q+ +V E E+ +L +E D + + K + A + S V E
Sbjct: 2203 QTLR-QKAQV---EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE--- 2255
Query: 121 DPPGGPAPTVLAPMPLAEV-ELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLS 179
+ + E+ +LK +E E + L+ + Q E ++++ + +
Sbjct: 2256 -------ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2308
Query: 180 EKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQ--LARTQKLQQELEAANQ 237
QE+ Q +E L + L+++ +A +A A + LQQ+ E A +
Sbjct: 2309 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2368
Query: 238 SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQT 297
L++ ++ + A + Q + A+ Q Q+E + AE L+ +A + + Q
Sbjct: 2369 QARRLQEDKEQMAQQLAEETQGFQRTL---EAERQRQLE-MSAEAERLKLRVAEMSRAQA 2424
Query: 298 AKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ 357
++ R+Q + +L + + ++ + L Q Q+S RL E + E+ +
Sbjct: 2425 RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER 2484
Query: 358 EKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYE 417
EKE+L QE + + +E+ + + E ++ Q Q EK+ L R R+
Sbjct: 2485 EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ--------SFLSEKDSLLQRERFI 2536
Query: 418 RELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
+ + E + E Q+REE+ R + QQ +E Q V SM+ A+ RR
Sbjct: 2537 EQEKAKLEQLFQDEVAKAQQLREEQQRQQ-----QQMEQERQRLVASMEEAR----RRQH 2587
Query: 478 EAE----GKEEELQDVRDQLEQAQE 498
EAE K+EELQ + Q Q +E
Sbjct: 2588 EAEEGVRRKQEELQQLEQQRRQQEE 2612
Score = 88.6 bits (218), Expect = 2e-17
Identities = 107/465 (23%), Positives = 194/465 (41%), Gaps = 69/465 (14%)
Query: 136 LAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTE 195
LAEVE E +++ + E + R+QEE+ + E Q+ +Q E
Sbjct: 1389 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEE 1448
Query: 196 KETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAA 255
+ L S +I+ ++ EA +++L ++++E+ L QR G E
Sbjct: 1449 LQQLRQSSEAEIQAKARQAEAAERSRL----RIEEEIRVVRLQLEATERQRGGAEGE-LQ 1503
Query: 256 ALRALQDQVSIQSADAQEQVEGLL----------------------AENNALRTSLAALE 293
ALRA ++ Q AQE+ E L AE A R AL+
Sbjct: 1504 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1563
Query: 294 QIQTAKTQ-----------ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESL 342
++ + Q E+ R+ L + +AE + + +QL+ SL
Sbjct: 1564 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1623
Query: 343 RANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVR 402
+ + QL+E + + Q E + AR+ AE+ +E Q K+ A+R
Sbjct: 1624 QEEHVAVAQLREEAERRAQQQAEAERAREEAERE--------LERWQLKANE-----ALR 1670
Query: 403 LRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQV 462
LR + E + + + E +++ +E RG+ E+ R REL +Q +E+ Q Q+
Sbjct: 1671 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL--AEQELEK-QRQL 1727
Query: 463 HSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQR 522
A+G ++RL E+EL +R + EQ +++R + ++ L++E ++
Sbjct: 1728 -----AEGTAQQRL----AAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ 1778
Query: 523 ILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE 567
LE + + K + +E A K + + T+ KS+ LE
Sbjct: 1779 ELEAELA------KVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1817
Score = 87.8 bits (216), Expect = 3e-17
Identities = 163/704 (23%), Positives = 291/704 (41%), Gaps = 154/704 (21%)
Query: 6 SEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK--AQKALSKSK 63
+E+E R++A+ + L +EL + E + QK L+ E +K A+ + +
Sbjct: 1738 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1797
Query: 64 KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKER-YGKEAGKFSAVSEGQGDP 122
KA+ E S +E + +L ++ FR L E ++ R +EA + ++E
Sbjct: 1798 KARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAKRQRQLAEEDAAR 1853
Query: 123 PGGPAPTVLAPMPLAEVE---LKWEME--KEEKRLLWEQLQGLESSKQAETSRLQEELAK 177
A VLA A E LK E E +EK E+L+ L + + RL+E+ A+
Sbjct: 1854 QRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1913
Query: 178 LSEKLKKKQESFCRLQTEKETLFNDSRNKIEE-LQQRKEADHKA-------QLARTQKLQ 229
+ +E +L+ ++ + +E+ L+QR++ + + + A K +
Sbjct: 1914 HKADI---EERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1970
Query: 230 QELEAAN-QSLAE--LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVE-GLLAENNAL 285
ELE +S AE LR + Q E AA R L + + +A+E+V+ L AE A
Sbjct: 1971 LELELGRIRSNAEDTLRSKEQAEL--EAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2028
Query: 286 RTSLAALEQIQT--AKTQELNMLREQTTGLAAE--------------------------- 316
R AALE+++ AK +E LRE+ +A
Sbjct: 2029 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088
Query: 317 -------LQQQQAEYEDLMGQKDDLNSQLQESLRA----------NSRLLEQLQEIGQEK 359
LQQ+Q+ + L G+ + +E+ A + R +E+ + + Q
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2148
Query: 360 EQLTQELQEARKSAEK----------RKAMLDELAM------------------ETLQEK 391
E+ Q +A+ +AEK R+A ++ A+ +TL++K
Sbjct: 2149 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2208
Query: 392 SQHKEELGAVRLR-----HEKEVLG---------------VRARYEREL-------RELH 424
+Q ++EL +RL+ H+K +L R++ E EL EL
Sbjct: 2209 AQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2268
Query: 425 EDKKRQEEELRGQIREEKARTR-----ELETLQQTVEEL--------------QAQVHSM 465
+ K R E E R I +K T+ E E ++Q EE Q +
Sbjct: 2269 KLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL 2328
Query: 466 DGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILE 525
+ E+ LKE +E ++ + E Q++++ + L QE K+ + Q E
Sbjct: 2329 AQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL-QEDKEQMAQQLAEE 2387
Query: 526 KKGSAALKDLKRQLHLERK-RADKLQERLQDILTNSKSRSGLEE 568
+G + +RQ LE A++L+ R+ ++ S++++ EE
Sbjct: 2388 TQGFQRTLEAERQRQLEMSAEAERLKLRVAEM---SRAQARAEE 2428
Score = 82.0 bits (201), Expect = 1e-15
Identities = 115/491 (23%), Positives = 210/491 (42%), Gaps = 59/491 (12%)
Query: 166 AETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLART 225
+ET R EE +L+E+ + ++ RL E E R E Q K +
Sbjct: 1365 SETLRRMEEEERLAEQQRAEERE--RL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQ 1421
Query: 226 QKLQQELEAANQSLAELRDQRQG--ERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN- 282
Q++Q+E+ ++ + + Q++ E L+ + Q + A+A E+ + E
Sbjct: 1422 QRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEI 1481
Query: 283 NALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQ-KDDLNSQLQES 341
+R L A E+ + EL LR + A+ +Q Q E E L Q +D+ + Q
Sbjct: 1482 RVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE 1541
Query: 342 LRANSRLLEQLQEIGQEKEQLTQELQEAR----------KSAEKRKAMLDELAMETLQ-- 389
+ SR+ + E +EK++ Q L+E R + AE +A ++A+ET Q
Sbjct: 1542 VELASRVKAEA-EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1600
Query: 390 -------------------EKSQHKEELGAVRLRHEKE------VLGVRARYERELRELH 424
E+S +E + +LR E E RAR E E REL
Sbjct: 1601 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE-RELE 1659
Query: 425 EDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKE 483
+ + E LR +++ EE A+ + L + ++ +A+ + K E+ +++ E E
Sbjct: 1660 RWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKA-EEQAVRQRELAE 1718
Query: 484 EELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLER 543
+EL+ R E ++R + + L+ E + +++LE ++L R L+R
Sbjct: 1719 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-------EELAR---LQR 1768
Query: 544 KRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESS 603
+ A Q+R + +K R+ +E L+ S+ + +++ S E R +E +
Sbjct: 1769 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE-AEAGRFRELA 1827
Query: 604 AVPARVRGKEE 614
AR+R E
Sbjct: 1828 EEAARLRALAE 1838
Score = 81.6 bits (200), Expect = 2e-15
Identities = 153/612 (25%), Positives = 241/612 (39%), Gaps = 98/612 (16%)
Query: 63 KKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
K+AQ V L E E +A L Q T A + R +E G+ G+ D
Sbjct: 1140 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD- 1198
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
EVE +W +E L E+ Q + A+T Q EL +L +L
Sbjct: 1199 --------------VEVE-RW---RERVAQLLERWQAV----LAQTDVRQRELEQLGRQL 1236
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKA---QLARTQKLQQELEAANQSL 239
+ +ES L D+R + E++Q AD +A QL + Q L +E+E
Sbjct: 1237 RYYRESADPLGA----WLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE------ 1286
Query: 240 AELRDQRQGERLEHAAA-----LRALQD-QVSIQSADAQ-EQVEGLLAENNALRTSLAAL 292
R GE++E + A++D ++ + + AQ E V + S + +
Sbjct: 1287 ------RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1340
Query: 293 EQIQTAKTQ--ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLE 350
++ +T EL L Q +E ++ E E L Q+ + + A
Sbjct: 1341 QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQR 1400
Query: 351 QLQEI-GQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEV 409
QL E Q K Q +E +E ++ ++ +E A++ Q+K +EEL +R E E+
Sbjct: 1401 QLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEI 1460
Query: 410 LG----------VRARYERELRELH---EDKKRQEEELRGQIREEKARTRELET----LQ 452
R R E E+R + E +RQ G+++ +AR E E Q
Sbjct: 1461 QAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQ 1520
Query: 453 QTVEELQAQVHSMDGAKGWFERRL-----KEAEGKEEE------LQDVRDQLEQAQEERD 501
+ E L+ QV K E L EAE E+ L+++R Q E+A ER
Sbjct: 1521 EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA--ERR 1578
Query: 502 CHLKTISSLKQEVKDTVDGQRILE-----KKGSAALK--DLKRQLHLERKRADKLQE--- 551
+ +Q QR E K+ S A K L+R L E +L+E
Sbjct: 1579 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1638
Query: 552 -RLQDILTNSKSRSGLE-ELVLSEMNSPS----RTQTGDSSSISSFSYREILREKESSAV 605
R Q ++R E EL ++ + R Q + + S + E ++KE +
Sbjct: 1639 RRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1698
Query: 606 PARVRGKEEPTA 617
AR RGK E A
Sbjct: 1699 EARRRGKAEEQA 1710
Score = 65.5 bits (158), Expect = 1e-10
Identities = 91/442 (20%), Positives = 182/442 (41%), Gaps = 62/442 (14%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKA-----QK 57
QA+ E + +A+LL+ + Q ++ R+ + + Q++A + F + Q+
Sbjct: 2344 QAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR 2401
Query: 58 ALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSE 117
L S +A+ +++ ++E QA+ + FR Q + + + + K + V
Sbjct: 2402 QLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQT 2460
Query: 118 GQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA----ETSRLQE 173
+ +AE+E + E ++E +LL + + +++ +Q ET LQ+
Sbjct: 2461 LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQ 2520
Query: 174 ELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELE 233
+ L +++ + + + E LF D K ++L++ + Q+ QQ++E
Sbjct: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQ-----------QRQQQQME 2569
Query: 234 AANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALE 293
Q L ++ + + E +R Q+++ ++Q E L EN LR L LE
Sbjct: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2629
Query: 294 Q--------------IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQ 339
+ Q A T+ L R+ G AAE + + + D L ++
Sbjct: 2630 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHS--------FDGLRRKVS 2681
Query: 340 ESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA-METLQEKSQHKEEL 398
++LQE G + Q L + + +DELA E ++ Q + +
Sbjct: 2682 ---------AQRLQEAGILSAEELQRLAQGHTT-------VDELARREDVRHYLQGRSSI 2725
Query: 399 GAVRLRHEKEVLGVRARYEREL 420
+ L+ E L V A +R+L
Sbjct: 2726 AGLLLKATNEKLSVYAALQRQL 2747
Score = 40.0 bits (92), Expect = 0.006
Identities = 87/388 (22%), Positives = 155/388 (39%), Gaps = 40/388 (10%)
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQ-SLAE 241
++ QE+ RL+ + + L L + D K+ LA Q L+++++ SLA
Sbjct: 890 QEAQEAVTRLEAQHQALVT--------LWHQLHVDMKSLLA-WQSLRRDVQLIRSWSLAT 940
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
R + E+ + AL +L+ D+Q+ A L A + +
Sbjct: 941 FRTLKPEEQRQ---ALHSLELHYQAFLRDSQD------AGGFGPEDRLMAEREYGSCSHH 991
Query: 302 ELNMLREQTTGLAAELQQQQ--AEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEK 359
+L+ G E + Q+ +E +D+ Q + ++ LR L +E +E
Sbjct: 992 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR-----LPLDKEPAREC 1046
Query: 360 EQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERE 419
Q E Q+A+ E + L+ E + + + A LR E E+ + R
Sbjct: 1047 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1106
Query: 420 LRELHEDK-KRQEEELRG-QIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLK 477
L ++ +K K +RG Q EE R E E L++ + + A + ++ K ++
Sbjct: 1107 LSAIYLEKLKTISLVIRGTQGAEEVLRAHE-EQLKEA-QAVPATLPELEATKASLKKLRA 1164
Query: 478 EAEGKEEELQDVRDQLEQAQE----------ERDCHLKTISSLKQEVKDTVDGQRILEKK 527
+AE ++ +RD+L AQE ERD ++ ++ +
Sbjct: 1165 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1224
Query: 528 GSAALKDLKRQLHLERKRADKLQERLQD 555
L+ L RQL R+ AD L LQD
Sbjct: 1225 RQRELEQLGRQLRYYRESADPLGAWLQD 1252
Score = 38.9 bits (89), Expect = 0.014
Identities = 77/373 (20%), Positives = 135/373 (36%), Gaps = 43/373 (11%)
Query: 133 PMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESF--- 189
P EVE + RLL+ +Q L+ + + ++ + +L E+L + +
Sbjct: 459 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 518
Query: 190 ---------------------CRLQTEKETL--FNDSRNKIEELQQRKE-ADHKAQLART 225
R + E TL D +EE Q R + A+ L
Sbjct: 519 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSV 578
Query: 226 QKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNAL 285
+ +QS+ E R + + R + A + Q LL + A
Sbjct: 579 EAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 638
Query: 286 RTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRAN 345
SL +L A T+EL L E+ E+ ++ M K + S L L
Sbjct: 639 LRSLESLHSFVAAATKELMWLNEKE---EEEVGFDWSDRNTNMTAKKESYSALMRELELK 695
Query: 346 SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRH 405
+ +++LQ G ++L +E AR + E +A LQ + +L H
Sbjct: 696 EKKIKELQNAG---DRLLREDHPARPTVESFQA--------ALQTQWSWMLQLCCCIEAH 744
Query: 406 EKEVLGVRARYERELRELHEDKKRQEEELRGQIR-EEKARTRELETLQQTVEELQAQVHS 464
KE ++ ++RE ++ +E LR + + A LE L Q ++ + Q++
Sbjct: 745 LKE-NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNE 803
Query: 465 MDGAKGWFERRLK 477
G +R K
Sbjct: 804 YKGHLSGLAKRAK 816
Score = 35.0 bits (79), Expect = 0.21
Identities = 50/233 (21%), Positives = 104/233 (44%), Gaps = 26/233 (11%)
Query: 165 QAETSRLQEELAKLSEKLKKK-QESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLA 223
+A+ R + + +LS + ++ RL + L N S+ ++ L E+ H A
Sbjct: 596 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSL----ESLHSFVAA 651
Query: 224 RTQKL----QQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 279
T++L ++E E ++ ++ ++A +R L+ + + + Q + LL
Sbjct: 652 ATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEK-KIKELQNAGDRLL 710
Query: 280 AENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYE---DLMGQKDDLNS 336
E++ R ++ E Q A + + + + + A L++ A ++ D+ + L
Sbjct: 711 REDHPARPTV---ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQ- 766
Query: 337 QLQESLRAN---------SRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAML 380
+LQE+LR +RL + LQ+ EKEQL + A++ KA++
Sbjct: 767 KLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 819
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 99.0 bits (245), Expect = 1e-20
Identities = 125/544 (22%), Positives = 246/544 (45%), Gaps = 57/544 (10%)
Query: 42 RQKVAYLDKEFSKAQKALSKSKKAQEVEVL-----LSENEMLQAKLHSQEEDFRLQNSTL 96
RQ+ + ++E +A++ +S K E E L E+L+ + +EE + +
Sbjct: 175 RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234
Query: 97 MAEFSKERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQ 156
F +E KE K V + + + E + + E+++EE++L +
Sbjct: 235 DRVFQEEEE-KEWRKRETVLRKEEEK-----------LQEEEPQRQRELQEEEEQLRKLE 282
Query: 157 LQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEE-----LQ 211
Q L +Q E Q++ + ++L++KQE R Q E+ + R + EE L+
Sbjct: 283 RQELRRERQEEEQ--QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR 340
Query: 212 QRKEADHKAQLARTQKLQQELEAANQSLA-ELRDQRQGERLEHAAALRALQDQVSIQSAD 270
+ +E + QL R +QE E Q L E ++R+ ++L LR Q Q
Sbjct: 341 REQEERREQQLRR----EQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLR 396
Query: 271 AQEQV--EGLLAENNALRTS--LAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYED 326
++Q+ E L LR L +Q++ + +E + + + L+++Q E D
Sbjct: 397 REQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD 456
Query: 327 LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME 386
+ ++++ QE + L++ QE + + L E +E R+ E+R+ L E
Sbjct: 457 WLKREEETERHEQERRKQQ---LKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513
Query: 387 TLQE--KSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDK-----------KRQEEE 433
++ K Q +EE RLR E+++ + +L + E+K KR++EE
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573
Query: 434 LRGQI--REEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRD 491
R Q+ REE+ R + L+ Q+ E L+ ++ + + E R ++ +EE ++ R
Sbjct: 574 RRDQLLKREEERRQQRLKREQE--ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631
Query: 492 QLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQE 551
QL +++E+ + + + +QE ++ QR+ ++ L+ ++ H E +R +L E
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERRE----QRLKREEEEERLEQRLKREHEEERREQELAE 687
Query: 552 RLQD 555
Q+
Sbjct: 688 EEQE 691
Score = 96.3 bits (238), Expect = 8e-20
Identities = 137/628 (21%), Positives = 267/628 (42%), Gaps = 87/628 (13%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
Q L E+ +R L Q ++ +E R++V L++E + Q+ +
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREE 624
Query: 63 KKAQEVEVLLS---ENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQ 119
+ + + LL + E Q +L ++++ R Q L E +ER + + +
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQERREQR--LKREEEEERLEQRLKREHEEERRE 682
Query: 120 GDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLS 179
+ LAE E + E+ + R+ Q Q LES A S++ K
Sbjct: 683 QE--------------LAEEEQEQARERIKSRIPKWQWQ-LESEADARQSKVYSRPRKQE 727
Query: 180 EKLKKKQESFCRLQTEKETLFNDS----RNKIEELQQRK-----EADHKAQLART----- 225
+ +++++ R + E E + + R + EE Q+R +A+ K++ R
Sbjct: 728 GQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSAR 787
Query: 226 ----QKLQQELEAANQSLAELR--------DQRQGERLEHAAALRALQDQVSIQSADA-- 271
++ +++L A + E R +QR+ +R E L+ L+++ +Q +
Sbjct: 788 PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQ 847
Query: 272 --QEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQ-QAEYEDLM 328
QE+ +GL + R+ +Q + +E R T LQ+Q + E + L
Sbjct: 848 QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ 907
Query: 329 GQKDDLNSQLQESLR--ANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME 386
++++L + +E R R + +++ QE+EQL +E +E R+ E+ + + ++
Sbjct: 908 EEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQ 967
Query: 387 TLQE-----------------KSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKR 429
+E K + +EEL + +E R R E E + +D+ +
Sbjct: 968 QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQ 1027
Query: 430 QEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERR--LKEAEGKEEELQ 487
QEEE + EK R +E E + EELQ + + G + RR L+ KEEELQ
Sbjct: 1028 QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQ 1087
Query: 488 DVRDQL------EQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHL 541
+QL ++ ++ER+ + L+QE + Q + E++ ++L+RQ
Sbjct: 1088 QEEEQLLREEPEKRRRQERERQCREEEELQQE-----EEQLLREEREKRRRQELERQYRE 1142
Query: 542 ERKRADKLQERLQDILTNSKSRSGLEEL 569
E +++Q+ + +L + +EL
Sbjct: 1143 E----EEVQQEEEQLLREEPEKRRRQEL 1166
Score = 95.5 bits (236), Expect = 1e-19
Identities = 130/574 (22%), Positives = 245/574 (42%), Gaps = 85/574 (14%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKAL--SKSKK 64
E E Q Q + + R QLS + R + + +++F + ++ L + +K
Sbjct: 1403 EREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK 1462
Query: 65 AQEVEVLLSENEMLQAKLHSQEEDFR-LQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPP 123
+E E LL E E + +LH QE D + L+ + ++R +E S E +
Sbjct: 1463 FREEEQLLQERE--EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK---- 1516
Query: 124 GGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLK 183
E E + ++ +++ L E+ Q + + + ++ + E+L+
Sbjct: 1517 ------------FLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLR 1564
Query: 184 KKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELR 243
+++E + E++ F K+ +Q ++ Q R Q+ QQ+L R
Sbjct: 1565 QEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD-----R 1619
Query: 244 DQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQEL 303
R+ E+L LQ++ Q QE+ L E LR E+ Q +
Sbjct: 1620 KFREDEQL--------LQEREE-QQLHRQERDRKFLEEEPQLRRQ----EREQQLRHDRD 1666
Query: 304 NMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLT 363
RE+ E Q+ E + L Q+ D + +E +QL+ +E++ L
Sbjct: 1667 RKFREE------EQLLQEGEEQQLRRQERDRKFREEE---------QQLRRQERERKFLQ 1711
Query: 364 QELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAV----RLRHEKEVLGVRARYERE 419
+E Q R+ E++ ++L ET QE+ + +E + +LR E+E E++
Sbjct: 1712 EEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE--------EQQ 1763
Query: 420 LRELHEDKK-RQEEELRGQIREEKART-------RELETLQQTVEELQAQVHSMDGAKGW 471
LR D+K R+EE+LR + E++ R+ RE E L+Q EE Q + DG W
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRW 1823
Query: 472 FERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAA 531
E +L + E +E+ L+ RD+ +A+E+ + K + Q + +++
Sbjct: 1824 EEEQL-QLEEQEQRLRQERDRQYRAEEQ----------FATQEKSRREEQELWQEEEQKR 1872
Query: 532 LKDLKRQLHLERKRADKLQERLQDILTNSKSRSG 565
++ +R+L E R + +E+ + KS+ G
Sbjct: 1873 RQERERKLREEHIRRQQKEEQRHRQVGEIKSQEG 1906
Score = 92.8 bits (229), Expect = 8e-19
Identities = 134/607 (22%), Positives = 266/607 (43%), Gaps = 86/607 (14%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
Q EE+ Q+ + QLL + + R+ + L+QK L E + ++ +
Sbjct: 929 QYREEEQLQQEEEQLLREEREKRRRQERERQYRKD-KKLQQKEEQLLGEEPEKRRRQERE 987
Query: 63 KKAQEVEVLLSENEML-------------QAKLHSQEEDFRLQNSTLMAEFSKERYGKEA 109
KK +E E L E E L + + ++E + + L E K R +
Sbjct: 988 KKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERE 1047
Query: 110 GKFSAVSEGQGDPP---GGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQA 166
++ E Q + G T + + E+++EE++LL E+ + ++
Sbjct: 1048 RQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERE 1107
Query: 167 ETSRLQEELAKLSEKL-------KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHK 219
R +EEL + E+L +++QE + + E+E + + EE ++R+ + +
Sbjct: 1108 RQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167
Query: 220 AQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLL 279
Q ++LQQE E Q L E +++R+ ER LQ Q Q ++Q L
Sbjct: 1168 RQYREEEELQQEEE---QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLK 1224
Query: 280 -----AENNALRTSLAALEQIQTAKTQEL--NMLREQTTGLAAELQQQQAEYEDLMGQKD 332
+ NA+R + + + + ++L + LR++ Q Q + + L+G++
Sbjct: 1225 WQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDR---------QSQQDLQHLLGEQQ 1275
Query: 333 DLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKS 392
+ + + + R +Q E+EQL +E Q+ K +++ +L E +EK
Sbjct: 1276 ERDREQER------RRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKR 1329
Query: 393 QHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQ-----IREEKARTRE 447
+ +E + R E+++L + R E+ LR D+K +EEELR Q EE+ R R
Sbjct: 1330 RRQET--DRKFREEEQLL--QEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRR 1385
Query: 448 LETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTI 507
E ++ ++E E++L+ + +E++L+ RD+ + +E++ +
Sbjct: 1386 QERERKFLKE---------------EQQLR-CQEREQQLRQDRDRKFREEEQQ------L 1423
Query: 508 SSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERL------QDILTNSK 561
S +++ K + Q++ ++ + ++QL ER R + +E+L Q + +
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483
Query: 562 SRSGLEE 568
R LEE
Sbjct: 1484 DRKFLEE 1490
Score = 91.7 bits (226), Expect = 2e-18
Identities = 139/616 (22%), Positives = 259/616 (42%), Gaps = 62/616 (10%)
Query: 2 AQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK 61
A+ SE QR+ A+ QL E R+ +++ +L +E K Q+ +
Sbjct: 773 AEEKSERGRQRLSARPPLREQRERQLRAEERQ--------QREQRFLPEEEEKEQRRRQR 824
Query: 62 SKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGD 121
++ +E++ L E E LQ + +Q+ LQ + +ER + + Q +
Sbjct: 825 REREKELQ-FLEEEEQLQRRERAQQ----LQEEEDGLQEDQERRRSQEQRRDQKWRWQLE 879
Query: 122 PPGGPAPTVLAPMPLAEVELKWE---MEKEEKRLLWEQLQGLESSKQAETSRLQEELAKL 178
L P + +L+ E +++EE+ L E+ + +Q R +E+L +
Sbjct: 880 EERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939
Query: 179 SEKLKKKQESFCRLQTEKETLFNDSR-NKIEELQQRKEADHKAQLARTQKLQQELEAANQ 237
E+L +++ R Q + D + + EE +E + + + R +K ++E E +
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQE 999
Query: 238 SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRT------SLAA 291
LR++R+ R + +D++ Q++ E LL E R
Sbjct: 1000 EEQLLREEREKRRRQEWERQYRKKDEL-------QQEEEQLLREEREKRRLQERERQYRE 1052
Query: 292 LEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLE- 350
E++Q + Q L RE T EL++Q + E+L +++ L + E R R +
Sbjct: 1053 EEELQQEEEQLLGEERE--TRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQC 1110
Query: 351 -QLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEV 409
+ +E+ QE+EQL +E +E R+ E + +E E QE+ Q E R R E E
Sbjct: 1111 REEEELQQEEEQLLREEREKRRRQELERQYREE--EEVQQEEEQLLREEPEKRRRQELE- 1167
Query: 410 LGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMD--- 466
+ R E EL++ E R+E+E R Q RE + R E Q+ + + + D
Sbjct: 1168 --RQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKW 1225
Query: 467 ------------------GAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTIS 508
G + R+L++++ ++ + Q L Q+ERD +
Sbjct: 1226 QWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR 1285
Query: 509 SLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEE 568
+++ + Q E++ A +D K Q + R ++ ++R + T+ K R E+
Sbjct: 1286 WQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ-ETDRKFREE-EQ 1343
Query: 569 LVLSEMNSPSRTQTGD 584
L+ P R Q D
Sbjct: 1344 LLQEREEQPLRRQERD 1359
Score = 89.7 bits (221), Expect = 7e-18
Identities = 131/594 (22%), Positives = 247/594 (41%), Gaps = 82/594 (13%)
Query: 3 QALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKS 62
Q EEE Q+ + QLL + EL + E ++Q+ L +E + ++
Sbjct: 1109 QCREEEELQQEEEQLLR-EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167
Query: 63 KKAQEVEVLLSENEML----QAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEG 118
++ +E E L E E L Q K + E + L + K+RY E +
Sbjct: 1168 RQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR------- 1220
Query: 119 QGDPPGGPAPTVLAPMPLAEVELKWEMEKEE---------KRLLWEQLQGLESSKQAETS 169
++++ +WE EKE K EQ + LE S+ +
Sbjct: 1221 ------------------SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ 1262
Query: 170 RLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRN-KIEELQQRKEADHKAQLARTQKL 228
Q+ L E+ ++ +E R +++ F + + EE ++ K D K+Q + Q L
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK-QLL 1321
Query: 229 QQELEAANQSLAELRDQRQGERL---EHAAALRALQDQVSIQSADAQEQVEG--LLAENN 283
++E E + R R+ E+L LR + + + + Q +G L E
Sbjct: 1322 REEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQ 1381
Query: 284 ALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLR 343
LR + +E L+E+ E +QQ + D ++++ QL R
Sbjct: 1382 RLRR-----------QERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE--QQLSRQER 1428
Query: 344 ANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRL 403
E+ Q QE+E+ E ++ + RK +E ++ +E+ H++E
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQE------ 1482
Query: 404 RHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEK--ARTRELETLQQTVEELQAQ 461
+++ L E++LR D+K +E+ELR Q E K ++L Q+ + LQ +
Sbjct: 1483 -RDRKFL----EEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537
Query: 462 VHSMDGAKGWFERRLKEAEGKEEE-LQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDG 520
+G R+ ++ + +EEE L+ R++ + +++ERD + +Q+V+
Sbjct: 1538 QQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERD---RKFRLEEQKVRRQEQE 1594
Query: 521 QRILEKKGSAALKDLKRQLHLERKRADKLQERL------QDILTNSKSRSGLEE 568
++ +E + ++ ++QL ER R + E+L Q + + R LEE
Sbjct: 1595 RKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE 1648
Score = 84.0 bits (206), Expect = 4e-16
Identities = 149/662 (22%), Positives = 267/662 (40%), Gaps = 94/662 (14%)
Query: 8 EEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQE 67
+E Q + +LLELR + + R+ + ++ +KE+ K + L K E
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEE----EKEWRKRETVLRK-----E 256
Query: 68 VEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGPA 127
E L E Q +L +EE R E +ER +E + E Q
Sbjct: 257 EEKLQEEEPQRQRELQEEEEQLRKLERQ---ELRRERQEEEQQQQRLRREQQ-------- 305
Query: 128 PTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE 187
+ + E + E ++EE+R E+ + E ++ + R QEE + ++L+++QE
Sbjct: 306 ------LRRKQEEERRE-QQEERREQQERREQQEERREQQLRREQEE--RREQQLRREQE 356
Query: 188 SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAAN-QSLAELRDQR 246
R Q + + R ++L++ ++ + QL R Q+L++E + Q L + R
Sbjct: 357 EERREQQLRREQEEERRE--QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414
Query: 247 QGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQI-----QTAKTQ 301
+ ++L LR Q++ + QE+ E L R E+ Q + Q
Sbjct: 415 REQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ 474
Query: 302 ELNM-----------------LREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRA 344
+L REQ +L+++Q E + ++ + +LQ+ LR+
Sbjct: 475 QLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRS 534
Query: 345 NSRLLEQLQEIGQ------EKEQLTQELQEAR--KSAEKRKAMLDELAMETLQE--KSQH 394
+L + +E + E+++L QE +E R + E+R+ L + E Q+ K +
Sbjct: 535 EQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ 594
Query: 395 KEELGAVRLRHEKEVLGVRARYEREL-RELHEDKKRQ--------EEELRGQIREEKART 445
+E L R E E L R E+ L RE E+++RQ EE + Q+R E+
Sbjct: 595 EERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654
Query: 446 RELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLE--------QAQ 497
RE ++ EE Q K E +E E EEE + R++++ Q +
Sbjct: 655 REQRLKREEEEERLEQ-----RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLE 709
Query: 498 EERDCHLKTISS--LKQEVKDTVDGQRILEKKGSAALK-DLKRQLHLERKRADKLQERLQ 554
E D + S KQE + Q ++ + L+ + + H +++ ++ ++
Sbjct: 710 SEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTW 769
Query: 555 DILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYRE--ILREKESSAVPARVRGK 612
KS G + L P R Q RE L E+E R R +
Sbjct: 770 QWQAEEKSERGRQRL---SARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826
Query: 613 EE 614
E
Sbjct: 827 RE 828
Score = 81.3 bits (199), Expect = 3e-15
Identities = 112/482 (23%), Positives = 205/482 (42%), Gaps = 43/482 (8%)
Query: 142 KWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQ--ESFCRLQTEKETL 199
+W+ E+EE+R EQLQ S K ET +E E+L++++ E + + EK+
Sbjct: 179 EWQ-EREERRAEEEQLQ---SCKGHETEEFPDE-----EQLRRRELLELRRKGREEKQQQ 229
Query: 200 FNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRA 259
+ ++++ + ++ KE +K + L + L E QRQ E E LR
Sbjct: 230 RRERQDRVFQEEEEKE---------WRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK 280
Query: 260 LQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQ 319
L+ Q + +EQ + L LR + Q + +E REQ E ++
Sbjct: 281 LERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE----ERRE 336
Query: 320 QQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAM 379
QQ E ++ L + +E R Q++ +E+E+ +E Q R+ +R+
Sbjct: 337 QQLRREQEERREQQLRREQEEERRE--------QQLRREQEEERREQQLRREQQLRREQQ 388
Query: 380 L---DELAME-TLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELR 435
L +L E L+ + Q + E R + + +R E E E +++R+E+ L+
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK 448
Query: 436 GQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRD-QLE 494
+ E + + E ++ +E + Q D + ER LK E + E Q+ R+ QL
Sbjct: 449 REQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR 508
Query: 495 QAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKL-QERL 553
+ QEER LK++ ++ QR+ ++ ++ +R+ L+R+ +L QER
Sbjct: 509 REQEER-----REQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563
Query: 554 QDILTNSKSRSGLEELVLSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARVRGKE 613
+ L + + L E R + + RE + E + +E
Sbjct: 564 EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKRE 623
Query: 614 EP 615
EP
Sbjct: 624 EP 625
Score = 68.2 bits (165), Expect = 2e-11
Identities = 92/363 (25%), Positives = 164/363 (45%), Gaps = 38/363 (10%)
Query: 196 KETLFNDSRNKIEELQQRKEA-DHKAQLARTQKLQQELEAANQSLAELRDQRQG-ERLEH 253
KE+L D R EE Q+R E D + + Q+ +Q+ + + LAE +Q + ERLE
Sbjct: 106 KESLLQDRRQ--EEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQ 163
Query: 254 AAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGL 313
R +++ Q + QE+ E E E+ + L E
Sbjct: 164 RDRQRR-DEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222
Query: 314 AAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKE-QLTQELQEARKS 372
E QQQ+ E +D + Q+++ ++ R +L + +E QE+E Q +ELQE +
Sbjct: 223 REEKQQQRRERQDRVFQEEE-----EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEE- 276
Query: 373 AEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEE 432
+ RK EL E +E+ Q + RLR E+++ R + E E R ++QEE
Sbjct: 277 -QLRKLERQELRRERQEEEQQQQ------RLRREQQL---RRKQEEERR------EQQEE 320
Query: 433 ELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFE---RRLKEAEGKEEELQDV 489
Q R E+ R + L++ EE + Q + + E RR +E E +E++L+
Sbjct: 321 RREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRRE 380
Query: 490 RDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKL 549
+ + Q R+ L+ L++E Q++ ++ + L+R+ L R++ ++
Sbjct: 381 QQLRREQQLRREQQLRREQQLRRE-------QQLRREQQLRREQQLRREQQLRREQEEER 433
Query: 550 QER 552
E+
Sbjct: 434 HEQ 436
Score = 32.0 bits (71), Expect = 1.8
Identities = 37/157 (23%), Positives = 67/157 (42%), Gaps = 15/157 (9%)
Query: 459 QAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQ-EERDCHLKTISSLKQEVKDT 517
QA +++ A G E + +GKE LQD R + +Q + E RD L+ ++ K
Sbjct: 83 QACYYALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQ 142
Query: 518 VDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSP 577
+ + E + + ++ Q +R R ++L + Q+ + R+ E+L
Sbjct: 143 EQERELAEGEEQSEKQERLEQRDRQR-RDEELWRQRQEWQEREERRAEEEQL-------- 193
Query: 578 SRTQTGDSSSISSFSYREILREKESSAVPARVRGKEE 614
Q+ F E LR +E + R +G+EE
Sbjct: 194 ---QSCKGHETEEFPDEEQLRRRE--LLELRRKGREE 225
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 98.6 bits (244), Expect = 2e-20
Identities = 147/636 (23%), Positives = 275/636 (43%), Gaps = 107/636 (16%)
Query: 14 QAQLLELRTNNYQLSDELRKNGV-ELTSLRQKVAYLDKEFSKAQKALSK----------- 61
Q ++L+ R Q EL++ E+ L+ +VA L++E ++ + L
Sbjct: 875 QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 934
Query: 62 ----SKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSE 117
+ + QE+E+++SE L+A++ +EE R + K+R + + A E
Sbjct: 935 RGRLAARKQELELVVSE---LEARVGEEEECSRQMQT------EKKRLQQHIQELEAHLE 985
Query: 118 GQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAK 177
+ + L +V + +M+K E+ LL + Q + SK E L++ LA+
Sbjct: 986 AEEG--------ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSK--ERKLLEDRLAE 1035
Query: 178 LSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQ 237
S + +++E S NK+ + AD + +L + +K +QELE
Sbjct: 1036 FSSQAAEEEEKV------------KSLNKLRLKYEATIADMEDRLRKEEKGRQELE---- 1079
Query: 238 SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQT 297
+L+ + GE E LQ+Q+ Q A+E L + L+ +LA E
Sbjct: 1080 ---KLKRRLDGESSE-------LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGG 1129
Query: 298 AKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ 357
A+ Q L LRE LA + L+ A ++ +Q +++G+
Sbjct: 1130 ARAQLLKSLREAQAALA------------------EAQEDLESERVARTKAEKQRRDLGE 1171
Query: 358 EKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYE 417
E E L EL++ S ++ EL + QE ++ K+ L HE V +R R+
Sbjct: 1172 ELEALRGELEDTLDSTNAQQ----ELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1227
Query: 418 RELRELHEDKKRQEE----------ELRGQIREEKARTRELETLQQTVEE----LQAQVH 463
+ L EL E ++ L ++ E +A L+T +Q E+ L+ Q+
Sbjct: 1228 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1287
Query: 464 SMDGAKGWFERRLKEAEGK----EEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD 519
+ G G ER EA K + EL++V L +A+ + K +SS + ++ D
Sbjct: 1288 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH---D 1344
Query: 520 GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE-ELVLSEMNSPS 578
Q +L+++ A L R +E + A L+E+L++ ++ R+G E + ++++
Sbjct: 1345 AQELLQEETRAKLALGSRVRAMEAEAAG-LREQLEEEAA-ARERAGRELQTAQAQLSEWR 1402
Query: 579 RTQTGDSSSISSFSYREILREKESSAVPARVRGKEE 614
R Q ++ ++ + +E+ A+ R+ K E
Sbjct: 1403 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE 1438
Score = 84.7 bits (208), Expect = 2e-16
Identities = 138/624 (22%), Positives = 255/624 (40%), Gaps = 63/624 (10%)
Query: 2 AQALSEEEFQRMQAQL-LELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKAL- 59
+QA EEE + +L L+ + D LRK L + LD E S+ Q+ +
Sbjct: 1038 SQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMV 1097
Query: 60 SKSKKAQEVEVLLS-ENEMLQAKLHSQEEDFRLQNSTL---------MAEFSKERYGKEA 109
+ ++A+E+ L + E LQA L E++ + L +AE ++ +
Sbjct: 1098 EQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERV 1157
Query: 110 GKFSA------VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEE-KRLLWEQLQGLES 162
+ A + E G T+ + E+ K E E E K+ L E+ + E+
Sbjct: 1158 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1217
Query: 163 SKQAETSRLQEELAKLSEKLKKKQE---SFCRLQTEKETLFNDSRNKIEELQ-QRKEADH 218
+ Q R + L +L+E+L++ + ++ + + E ++ R ++ LQ R+E +
Sbjct: 1218 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1277
Query: 219 K-----AQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQ---------- 263
+ QL Q + E A AE + Q E + AL + +
Sbjct: 1278 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1337
Query: 264 VSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAE 323
Q DAQE ++ AL + + A+E ++L ELQ QA+
Sbjct: 1338 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ 1397
Query: 324 YEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDEL 383
+ ++++ L+ A R + + + Q + T+ + + + + LD+
Sbjct: 1398 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDA 1457
Query: 384 AMETLQ--------EKSQHK-------EELGAVRLRHEKEVLGVRARYERELRELHEDKK 428
M+ Q EK Q K E+ +R E+E R ERE R L +
Sbjct: 1458 TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGR-EREARALSLTRA 1516
Query: 429 RQEE-ELRGQI-REEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEEL 486
+EE E R ++ R+ +A ELE L + +++ VH ++ A E+ + + EL
Sbjct: 1517 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1576
Query: 487 QDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLH-LERKR 545
+D E A+ + T+ +LK + + + G+ ++ G + L +QL E +R
Sbjct: 1577 EDELTAAEDAKLRLEV---TVQALKTQHERDLQGR---DEAGEERRRQLAKQLRDAEVER 1630
Query: 546 ADKLQERLQDILTNSKSRSGLEEL 569
++ ++R + K LEEL
Sbjct: 1631 DEERKQRTLAVAARKKLEGELEEL 1654
Score = 81.6 bits (200), Expect = 2e-15
Identities = 119/563 (21%), Positives = 248/563 (44%), Gaps = 60/563 (10%)
Query: 2 AQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK 61
A+AL++ ++ + + L +L EL ++L RQ V+ L+K+ K + L++
Sbjct: 1426 AEALTQRLAEKTET-VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1484
Query: 62 SKKAQEVEVLLSENEMLQAKLHSQE-----------------EDFRLQNSTLMAEF---- 100
K A V + E E +A+ +E E+ QN L AE
Sbjct: 1485 EKAA--VLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALL 1542
Query: 101 -SKERYGK---EAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQ 156
SK+ GK E + V+E + + + AE + K +E + L +
Sbjct: 1543 SSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE-DAKLRLEVTVQALKTQH 1601
Query: 157 LQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIE-ELQQRKE 215
+ L+ +A R ++ +L + ++ E + ++ TL +R K+E EL++ K
Sbjct: 1602 ERDLQGRDEAGEERRRQLAKQLRDAEVERDE-----ERKQRTLAVAARKKLEGELEELK- 1655
Query: 216 ADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQV 275
AQ+A + ++E A + L +++ Q + E R ++++ Q+ ++++++
Sbjct: 1656 ----AQMASAGQGKEE---AVKQLRKMQAQMK-ELWREVEETRTSREEIFSQNRESEKRL 1707
Query: 276 EGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLN 335
+GL AE L+ LAA ++ + Q+ + + ++ E L G+ L
Sbjct: 1708 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE 1767
Query: 336 SQLQESLRANSRLL-EQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQH 394
+L+E ++NS LL ++ +++ + E LT EL R + K ++ + Q
Sbjct: 1768 EELEEE-QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAES-----------GRQQL 1815
Query: 395 KEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQT 454
+ ++ +R R +E G RAR++ + L + EE+L + RE + + ++
Sbjct: 1816 ERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKR 1875
Query: 455 VEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEV 514
++E+ QV +L++ + ++L + QLE+A+EE L++E+
Sbjct: 1876 LKEVVLQVEEERRVADQLRDQLEKGNLRVKQL---KRQLEEAEEEASRAQAGRRRLQREL 1932
Query: 515 KDTVDGQRILEKKGSAALKDLKR 537
+D + + ++ + L+R
Sbjct: 1933 EDVTESAESMNREVTTLRNRLRR 1955
Score = 80.9 bits (198), Expect = 3e-15
Identities = 148/675 (21%), Positives = 262/675 (38%), Gaps = 141/675 (20%)
Query: 2 AQALSEEEFQRMQAQLL-------ELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK 54
A+A + E+ QR QA+L E + +LS EL +L ++ L +E ++
Sbjct: 1299 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE----LLQEETR 1354
Query: 55 AQKALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSA 114
A+ AL +A E E ++ + + LQ + + R +EAG A
Sbjct: 1355 AKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEA 1414
Query: 115 VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEE 174
E + L + E +E+ +RL E + + E+
Sbjct: 1415 GEEARRR--AAREAEALTQRLAEKTETVDRLERGRRRLQQEL---------DDATMDLEQ 1463
Query: 175 LAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEA 234
+L L+KKQ F +L E++ +EE ++R EA+ + + AR L + LE
Sbjct: 1464 QRQLVSTLEKKQRKFDQLLAEEKAAV---LRAVEE-RERAEAEGREREARALSLTRALEE 1519
Query: 235 ANQSLAELRDQRQGERLEHAAALRALQD------------QVSIQSA-DAQEQVEGLLAE 281
++ EL Q + R E A L + D +V+ Q+A D + QV L E
Sbjct: 1520 EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE 1579
Query: 282 NNALRTSLAALE-QIQTAKTQELNMLR-------EQTTGLAAELQQQQAEYED------- 326
A + LE +Q KTQ L+ E+ LA +L+ + E ++
Sbjct: 1580 LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1639
Query: 327 -------LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEK---- 375
L G+ ++L +Q+ + + ++QL+++ + ++L +E++E R S E+
Sbjct: 1640 AVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQ 1699
Query: 376 -----------------------------------RKAMLDELA------METLQEKSQH 394
R M DE+A L+EK Q
Sbjct: 1700 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL 1759
Query: 395 KEELGAVRLRHEKEVLG---VRARYERELRELH--------------------EDKKRQE 431
+ LG + E+E + RY + L ++ + +RQ
Sbjct: 1760 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1819
Query: 432 EELRGQIREEKARTRE--------LET-LQQTVEELQAQVHS--MDGAK-GWFERRLKEA 479
+ELRG++ EE A R LE+ L Q E+L+ + + G E+RLKE
Sbjct: 1820 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEV 1879
Query: 480 EGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 539
+ EE + V DQL E+ + +K + +E ++ + ++ L+D+
Sbjct: 1880 VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESA 1939
Query: 540 HLERKRADKLQERLQ 554
+ L+ RL+
Sbjct: 1940 ESMNREVTTLRNRLR 1954
Score = 78.6 bits (192), Expect = 2e-14
Identities = 164/678 (24%), Positives = 290/678 (42%), Gaps = 116/678 (17%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELR---------KNGVELT--SLRQKVAYLDKEFSKA 55
EEE + +A + ELR + Q EL K E T +L +V+ L E S
Sbjct: 1209 EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL 1268
Query: 56 QKALSKSKKA--------QEVEVLLSENEMLQAKL-----HSQEEDFRLQNSTLMAEFSK 102
Q A + ++ QEV+ + E +A+ +Q E + + AE
Sbjct: 1269 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1328
Query: 103 ERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRL--LWEQLQGL 160
R KE A A +L A++ L + E L EQL+
Sbjct: 1329 IRLSKELSSTEAQLHD--------AQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1380
Query: 161 ESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNK---IEELQQRKEAD 217
++++ LQ A+LSE ++++E L+ +E +R + L ++ E
Sbjct: 1381 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETV 1440
Query: 218 HKAQLARTQKLQQELEAANQSLAELRD--------QRQGERL---EHAAALRALQDQVSI 266
+ + R ++LQQEL+ A L + R QR+ ++L E AA LRA++++
Sbjct: 1441 DRLERGR-RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER--- 1496
Query: 267 QSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYED 326
+ + EG E AL + ALE+ Q A+ + L Q L AEL E
Sbjct: 1497 ----ERAEAEGREREARALSLT-RALEEEQEAREE----LERQNRALRAEL-------EA 1540
Query: 327 LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME 386
L+ KDD+ + E RA R+ EQ + Q+T EL++ +AE K L+
Sbjct: 1541 LLSSKDDVGKSVHELERA-CRVAEQAAN--DLRAQVT-ELEDELTAAEDAKLRLEV---- 1592
Query: 387 TLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTR 446
T+Q A++ +HE+++ G E R+L + + E E + ++
Sbjct: 1593 TVQ----------ALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVA 1642
Query: 447 ELETLQQTVEELQAQVHSMDGAKGWFERRLK--EAEGKE-----EELQDVRDQLEQAQEE 499
+ L+ +EEL+AQ+ S K ++L+ +A+ KE EE + R+++ E
Sbjct: 1643 ARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRE 1702
Query: 500 RDCHLKTISS----LKQEVKDTVDGQRILEKK-------------GSAALKDLKRQLHLE 542
+ LK + + L++E+ + +R ++ AA+ + KRQL
Sbjct: 1703 SEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL--- 1759
Query: 543 RKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSS-SISSFSYREILREKE 601
R +L+E L++ +NS+ + +L ++ S + + + S S + S R+ L E++
Sbjct: 1760 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQL-ERQ 1818
Query: 602 SSAVPARVRGKEEPTAPA 619
+ R+ G+E+ A A
Sbjct: 1819 IQELRGRL-GEEDAGARA 1835
Score = 75.1 bits (183), Expect = 2e-13
Identities = 97/415 (23%), Positives = 188/415 (45%), Gaps = 50/415 (12%)
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
L+ RQ E L+ A ++ QSA +++G +A+ R LA + +
Sbjct: 870 LQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA 929
Query: 302 ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQL------QEI 355
E R + EL+ +E E +G++++ + Q+Q + + +++L +E
Sbjct: 930 EAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 989
Query: 356 GQEKEQLTQELQEAR----------------KSAEKRKAMLDELAMETLQ--EKSQHKEE 397
++K QL + EA+ K +++RK + D LA + Q E+ + +
Sbjct: 990 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKS 1049
Query: 398 LGAVRLRHEKEVLGVRARYERE---LRELHEDKKR---QEEELRGQIREEKARTRELET- 450
L +RL++E + + R +E +EL + K+R + EL+ Q+ E++ R EL
Sbjct: 1050 LNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ 1109
Query: 451 LQQTVEELQ---AQVHSMDGAKGWFERRLKEAEG----KEEELQDVRDQLEQAQEERDCH 503
L + EELQ A+ GA+ + L+EA+ +E+L+ R +A+++R
Sbjct: 1110 LGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDL 1169
Query: 504 LKTISSLKQEVKDTVD---GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNS 560
+ + +L+ E++DT+D Q+ L K + +LK+ L E + + + L
Sbjct: 1170 GEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQEL------- 1222
Query: 561 KSRSGLEELVLSEMNSPSRTQTG--DSSSISSFSYREILREKESSAVPARVRGKE 613
+ R G L+E +R G + + ++ + LR + SS AR G++
Sbjct: 1223 RQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1277
Score = 32.3 bits (72), Expect = 1.3
Identities = 47/247 (19%), Positives = 103/247 (41%), Gaps = 25/247 (10%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK-SKKA 65
E +++ +L E ++N+ L+D RK +++ SL +++ +KA+ + ++
Sbjct: 1760 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1819
Query: 66 QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE---AGKFSAVSEGQGDP 122
QE+ L E + A+ + L++ AE E+ +E +GK +E +
Sbjct: 1820 QELRGRLGEEDA-GARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKR--- 1875
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
L EV L + EE+R + +QL+ +L+ +L + E+
Sbjct: 1876 -------------LKEVVL----QVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEA 1918
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAEL 242
+ Q RLQ E E + + + E+ + + L T + +++ + +A
Sbjct: 1919 SRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASD 1978
Query: 243 RDQRQGE 249
+ + +
Sbjct: 1979 EEAEEAQ 1985
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 98.6 bits (244), Expect = 2e-20
Identities = 147/636 (23%), Positives = 275/636 (43%), Gaps = 107/636 (16%)
Query: 14 QAQLLELRTNNYQLSDELRKNGV-ELTSLRQKVAYLDKEFSKAQKALSK----------- 61
Q ++L+ R Q EL++ E+ L+ +VA L++E ++ + L
Sbjct: 867 QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 926
Query: 62 ----SKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSE 117
+ + QE+E+++SE L+A++ +EE R + K+R + + A E
Sbjct: 927 RGRLAARKQELELVVSE---LEARVGEEEECSRQMQT------EKKRLQQHIQELEAHLE 977
Query: 118 GQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAK 177
+ + L +V + +M+K E+ LL + Q + SK E L++ LA+
Sbjct: 978 AEEG--------ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSK--ERKLLEDRLAE 1027
Query: 178 LSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQ 237
S + +++E S NK+ + AD + +L + +K +QELE
Sbjct: 1028 FSSQAAEEEEKV------------KSLNKLRLKYEATIADMEDRLRKEEKGRQELE---- 1071
Query: 238 SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQT 297
+L+ + GE E LQ+Q+ Q A+E L + L+ +LA E
Sbjct: 1072 ---KLKRRLDGESSE-------LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGG 1121
Query: 298 AKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ 357
A+ Q L LRE LA + L+ A ++ +Q +++G+
Sbjct: 1122 ARAQLLKSLREAQAALA------------------EAQEDLESERVARTKAEKQRRDLGE 1163
Query: 358 EKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYE 417
E E L EL++ S ++ EL + QE ++ K+ L HE V +R R+
Sbjct: 1164 ELEALRGELEDTLDSTNAQQ----ELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1219
Query: 418 RELRELHEDKKRQEE----------ELRGQIREEKARTRELETLQQTVEE----LQAQVH 463
+ L EL E ++ L ++ E +A L+T +Q E+ L+ Q+
Sbjct: 1220 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1279
Query: 464 SMDGAKGWFERRLKEAEGK----EEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD 519
+ G G ER EA K + EL++V L +A+ + K +SS + ++ D
Sbjct: 1280 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH---D 1336
Query: 520 GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE-ELVLSEMNSPS 578
Q +L+++ A L R +E + A L+E+L++ ++ R+G E + ++++
Sbjct: 1337 AQELLQEETRAKLALGSRVRAMEAEAAG-LREQLEEEAA-ARERAGRELQTAQAQLSEWR 1394
Query: 579 RTQTGDSSSISSFSYREILREKESSAVPARVRGKEE 614
R Q ++ ++ + +E+ A+ R+ K E
Sbjct: 1395 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE 1430
Score = 84.7 bits (208), Expect = 2e-16
Identities = 138/624 (22%), Positives = 255/624 (40%), Gaps = 63/624 (10%)
Query: 2 AQALSEEEFQRMQAQL-LELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKAL- 59
+QA EEE + +L L+ + D LRK L + LD E S+ Q+ +
Sbjct: 1030 SQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMV 1089
Query: 60 SKSKKAQEVEVLLS-ENEMLQAKLHSQEEDFRLQNSTL---------MAEFSKERYGKEA 109
+ ++A+E+ L + E LQA L E++ + L +AE ++ +
Sbjct: 1090 EQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERV 1149
Query: 110 GKFSA------VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEE-KRLLWEQLQGLES 162
+ A + E G T+ + E+ K E E E K+ L E+ + E+
Sbjct: 1150 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1209
Query: 163 SKQAETSRLQEELAKLSEKLKKKQE---SFCRLQTEKETLFNDSRNKIEELQ-QRKEADH 218
+ Q R + L +L+E+L++ + ++ + + E ++ R ++ LQ R+E +
Sbjct: 1210 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1269
Query: 219 K-----AQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQ---------- 263
+ QL Q + E A AE + Q E + AL + +
Sbjct: 1270 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1329
Query: 264 VSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAE 323
Q DAQE ++ AL + + A+E ++L ELQ QA+
Sbjct: 1330 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ 1389
Query: 324 YEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDEL 383
+ ++++ L+ A R + + + Q + T+ + + + + LD+
Sbjct: 1390 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDA 1449
Query: 384 AMETLQ--------EKSQHK-------EELGAVRLRHEKEVLGVRARYERELRELHEDKK 428
M+ Q EK Q K E+ +R E+E R ERE R L +
Sbjct: 1450 TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGR-EREARALSLTRA 1508
Query: 429 RQEE-ELRGQI-REEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEEL 486
+EE E R ++ R+ +A ELE L + +++ VH ++ A E+ + + EL
Sbjct: 1509 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1568
Query: 487 QDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLH-LERKR 545
+D E A+ + T+ +LK + + + G+ ++ G + L +QL E +R
Sbjct: 1569 EDELTAAEDAKLRLEV---TVQALKTQHERDLQGR---DEAGEERRRQLAKQLRDAEVER 1622
Query: 546 ADKLQERLQDILTNSKSRSGLEEL 569
++ ++R + K LEEL
Sbjct: 1623 DEERKQRTLAVAARKKLEGELEEL 1646
Score = 81.6 bits (200), Expect = 2e-15
Identities = 119/563 (21%), Positives = 248/563 (44%), Gaps = 60/563 (10%)
Query: 2 AQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK 61
A+AL++ ++ + + L +L EL ++L RQ V+ L+K+ K + L++
Sbjct: 1418 AEALTQRLAEKTET-VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1476
Query: 62 SKKAQEVEVLLSENEMLQAKLHSQE-----------------EDFRLQNSTLMAEF---- 100
K A V + E E +A+ +E E+ QN L AE
Sbjct: 1477 EKAA--VLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALL 1534
Query: 101 -SKERYGK---EAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQ 156
SK+ GK E + V+E + + + AE + K +E + L +
Sbjct: 1535 SSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE-DAKLRLEVTVQALKTQH 1593
Query: 157 LQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIE-ELQQRKE 215
+ L+ +A R ++ +L + ++ E + ++ TL +R K+E EL++ K
Sbjct: 1594 ERDLQGRDEAGEERRRQLAKQLRDAEVERDE-----ERKQRTLAVAARKKLEGELEELK- 1647
Query: 216 ADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQV 275
AQ+A + ++E A + L +++ Q + E R ++++ Q+ ++++++
Sbjct: 1648 ----AQMASAGQGKEE---AVKQLRKMQAQMK-ELWREVEETRTSREEIFSQNRESEKRL 1699
Query: 276 EGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLN 335
+GL AE L+ LAA ++ + Q+ + + ++ E L G+ L
Sbjct: 1700 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE 1759
Query: 336 SQLQESLRANSRLL-EQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQH 394
+L+E ++NS LL ++ +++ + E LT EL R + K ++ + Q
Sbjct: 1760 EELEEE-QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAES-----------GRQQL 1807
Query: 395 KEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQT 454
+ ++ +R R +E G RAR++ + L + EE+L + RE + + ++
Sbjct: 1808 ERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKR 1867
Query: 455 VEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEV 514
++E+ QV +L++ + ++L + QLE+A+EE L++E+
Sbjct: 1868 LKEVVLQVEEERRVADQLRDQLEKGNLRVKQL---KRQLEEAEEEASRAQAGRRRLQREL 1924
Query: 515 KDTVDGQRILEKKGSAALKDLKR 537
+D + + ++ + L+R
Sbjct: 1925 EDVTESAESMNREVTTLRNRLRR 1947
Score = 80.9 bits (198), Expect = 3e-15
Identities = 148/675 (21%), Positives = 262/675 (38%), Gaps = 141/675 (20%)
Query: 2 AQALSEEEFQRMQAQLL-------ELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK 54
A+A + E+ QR QA+L E + +LS EL +L ++ L +E ++
Sbjct: 1291 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE----LLQEETR 1346
Query: 55 AQKALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSA 114
A+ AL +A E E ++ + + LQ + + R +EAG A
Sbjct: 1347 AKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEA 1406
Query: 115 VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEE 174
E + L + E +E+ +RL E + + E+
Sbjct: 1407 GEEARRR--AAREAEALTQRLAEKTETVDRLERGRRRLQQEL---------DDATMDLEQ 1455
Query: 175 LAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEA 234
+L L+KKQ F +L E++ +EE ++R EA+ + + AR L + LE
Sbjct: 1456 QRQLVSTLEKKQRKFDQLLAEEKAAV---LRAVEE-RERAEAEGREREARALSLTRALEE 1511
Query: 235 ANQSLAELRDQRQGERLEHAAALRALQD------------QVSIQSA-DAQEQVEGLLAE 281
++ EL Q + R E A L + D +V+ Q+A D + QV L E
Sbjct: 1512 EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE 1571
Query: 282 NNALRTSLAALE-QIQTAKTQELNMLR-------EQTTGLAAELQQQQAEYED------- 326
A + LE +Q KTQ L+ E+ LA +L+ + E ++
Sbjct: 1572 LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1631
Query: 327 -------LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEK---- 375
L G+ ++L +Q+ + + ++QL+++ + ++L +E++E R S E+
Sbjct: 1632 AVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQ 1691
Query: 376 -----------------------------------RKAMLDELA------METLQEKSQH 394
R M DE+A L+EK Q
Sbjct: 1692 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL 1751
Query: 395 KEELGAVRLRHEKEVLG---VRARYERELRELH--------------------EDKKRQE 431
+ LG + E+E + RY + L ++ + +RQ
Sbjct: 1752 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1811
Query: 432 EELRGQIREEKARTRE--------LET-LQQTVEELQAQVHS--MDGAK-GWFERRLKEA 479
+ELRG++ EE A R LE+ L Q E+L+ + + G E+RLKE
Sbjct: 1812 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEV 1871
Query: 480 EGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 539
+ EE + V DQL E+ + +K + +E ++ + ++ L+D+
Sbjct: 1872 VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESA 1931
Query: 540 HLERKRADKLQERLQ 554
+ L+ RL+
Sbjct: 1932 ESMNREVTTLRNRLR 1946
Score = 78.6 bits (192), Expect = 2e-14
Identities = 164/678 (24%), Positives = 290/678 (42%), Gaps = 116/678 (17%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELR---------KNGVELT--SLRQKVAYLDKEFSKA 55
EEE + +A + ELR + Q EL K E T +L +V+ L E S
Sbjct: 1201 EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL 1260
Query: 56 QKALSKSKKA--------QEVEVLLSENEMLQAKL-----HSQEEDFRLQNSTLMAEFSK 102
Q A + ++ QEV+ + E +A+ +Q E + + AE
Sbjct: 1261 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1320
Query: 103 ERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRL--LWEQLQGL 160
R KE A A +L A++ L + E L EQL+
Sbjct: 1321 IRLSKELSSTEAQLHD--------AQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1372
Query: 161 ESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNK---IEELQQRKEAD 217
++++ LQ A+LSE ++++E L+ +E +R + L ++ E
Sbjct: 1373 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETV 1432
Query: 218 HKAQLARTQKLQQELEAANQSLAELRD--------QRQGERL---EHAAALRALQDQVSI 266
+ + R ++LQQEL+ A L + R QR+ ++L E AA LRA++++
Sbjct: 1433 DRLERGR-RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER--- 1488
Query: 267 QSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYED 326
+ + EG E AL + ALE+ Q A+ + L Q L AEL E
Sbjct: 1489 ----ERAEAEGREREARALSLT-RALEEEQEAREE----LERQNRALRAEL-------EA 1532
Query: 327 LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME 386
L+ KDD+ + E RA R+ EQ + Q+T EL++ +AE K L+
Sbjct: 1533 LLSSKDDVGKSVHELERA-CRVAEQAAN--DLRAQVT-ELEDELTAAEDAKLRLEV---- 1584
Query: 387 TLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTR 446
T+Q A++ +HE+++ G E R+L + + E E + ++
Sbjct: 1585 TVQ----------ALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVA 1634
Query: 447 ELETLQQTVEELQAQVHSMDGAKGWFERRLK--EAEGKE-----EELQDVRDQLEQAQEE 499
+ L+ +EEL+AQ+ S K ++L+ +A+ KE EE + R+++ E
Sbjct: 1635 ARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRE 1694
Query: 500 RDCHLKTISS----LKQEVKDTVDGQRILEKK-------------GSAALKDLKRQLHLE 542
+ LK + + L++E+ + +R ++ AA+ + KRQL
Sbjct: 1695 SEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL--- 1751
Query: 543 RKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSS-SISSFSYREILREKE 601
R +L+E L++ +NS+ + +L ++ S + + + S S + S R+ L E++
Sbjct: 1752 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQL-ERQ 1810
Query: 602 SSAVPARVRGKEEPTAPA 619
+ R+ G+E+ A A
Sbjct: 1811 IQELRGRL-GEEDAGARA 1827
Score = 75.1 bits (183), Expect = 2e-13
Identities = 97/415 (23%), Positives = 188/415 (45%), Gaps = 50/415 (12%)
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
L+ RQ E L+ A ++ QSA +++G +A+ R LA + +
Sbjct: 862 LQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA 921
Query: 302 ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQL------QEI 355
E R + EL+ +E E +G++++ + Q+Q + + +++L +E
Sbjct: 922 EAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 981
Query: 356 GQEKEQLTQELQEAR----------------KSAEKRKAMLDELAMETLQ--EKSQHKEE 397
++K QL + EA+ K +++RK + D LA + Q E+ + +
Sbjct: 982 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKS 1041
Query: 398 LGAVRLRHEKEVLGVRARYERE---LRELHEDKKR---QEEELRGQIREEKARTRELET- 450
L +RL++E + + R +E +EL + K+R + EL+ Q+ E++ R EL
Sbjct: 1042 LNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ 1101
Query: 451 LQQTVEELQ---AQVHSMDGAKGWFERRLKEAEG----KEEELQDVRDQLEQAQEERDCH 503
L + EELQ A+ GA+ + L+EA+ +E+L+ R +A+++R
Sbjct: 1102 LGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDL 1161
Query: 504 LKTISSLKQEVKDTVD---GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNS 560
+ + +L+ E++DT+D Q+ L K + +LK+ L E + + + L
Sbjct: 1162 GEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQEL------- 1214
Query: 561 KSRSGLEELVLSEMNSPSRTQTG--DSSSISSFSYREILREKESSAVPARVRGKE 613
+ R G L+E +R G + + ++ + LR + SS AR G++
Sbjct: 1215 RQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1269
Score = 32.3 bits (72), Expect = 1.3
Identities = 47/247 (19%), Positives = 103/247 (41%), Gaps = 25/247 (10%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK-SKKA 65
E +++ +L E ++N+ L+D RK +++ SL +++ +KA+ + ++
Sbjct: 1752 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1811
Query: 66 QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE---AGKFSAVSEGQGDP 122
QE+ L E + A+ + L++ AE E+ +E +GK +E +
Sbjct: 1812 QELRGRLGEEDA-GARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKR--- 1867
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
L EV L + EE+R + +QL+ +L+ +L + E+
Sbjct: 1868 -------------LKEVVL----QVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEA 1910
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAEL 242
+ Q RLQ E E + + + E+ + + L T + +++ + +A
Sbjct: 1911 SRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASD 1970
Query: 243 RDQRQGE 249
+ + +
Sbjct: 1971 EEAEEAQ 1977
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 98.6 bits (244), Expect = 2e-20
Identities = 147/636 (23%), Positives = 275/636 (43%), Gaps = 107/636 (16%)
Query: 14 QAQLLELRTNNYQLSDELRKNGV-ELTSLRQKVAYLDKEFSKAQKALSK----------- 61
Q ++L+ R Q EL++ E+ L+ +VA L++E ++ + L
Sbjct: 908 QDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEET 967
Query: 62 ----SKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSE 117
+ + QE+E+++SE L+A++ +EE R + K+R + + A E
Sbjct: 968 RGRLAARKQELELVVSE---LEARVGEEEECSRQMQT------EKKRLQQHIQELEAHLE 1018
Query: 118 GQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAK 177
+ + L +V + +M+K E+ LL + Q + SK E L++ LA+
Sbjct: 1019 AEEG--------ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSK--ERKLLEDRLAE 1068
Query: 178 LSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQ 237
S + +++E S NK+ + AD + +L + +K +QELE
Sbjct: 1069 FSSQAAEEEEKV------------KSLNKLRLKYEATIADMEDRLRKEEKGRQELE---- 1112
Query: 238 SLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQT 297
+L+ + GE E LQ+Q+ Q A+E L + L+ +LA E
Sbjct: 1113 ---KLKRRLDGESSE-------LQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGG 1162
Query: 298 AKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQ 357
A+ Q L LRE LA + L+ A ++ +Q +++G+
Sbjct: 1163 ARAQLLKSLREAQAALA------------------EAQEDLESERVARTKAEKQRRDLGE 1204
Query: 358 EKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYE 417
E E L EL++ S ++ EL + QE ++ K+ L HE V +R R+
Sbjct: 1205 ELEALRGELEDTLDSTNAQQ----ELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHG 1260
Query: 418 RELRELHEDKKRQEE----------ELRGQIREEKARTRELETLQQTVEE----LQAQVH 463
+ L EL E ++ L ++ E +A L+T +Q E+ L+ Q+
Sbjct: 1261 QALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQ 1320
Query: 464 SMDGAKGWFERRLKEAEGK----EEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD 519
+ G G ER EA K + EL++V L +A+ + K +SS + ++ D
Sbjct: 1321 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLH---D 1377
Query: 520 GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLE-ELVLSEMNSPS 578
Q +L+++ A L R +E + A L+E+L++ ++ R+G E + ++++
Sbjct: 1378 AQELLQEETRAKLALGSRVRAMEAEAAG-LREQLEEEAA-ARERAGRELQTAQAQLSEWR 1435
Query: 579 RTQTGDSSSISSFSYREILREKESSAVPARVRGKEE 614
R Q ++ ++ + +E+ A+ R+ K E
Sbjct: 1436 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTE 1471
Score = 84.7 bits (208), Expect = 2e-16
Identities = 138/624 (22%), Positives = 255/624 (40%), Gaps = 63/624 (10%)
Query: 2 AQALSEEEFQRMQAQL-LELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKAL- 59
+QA EEE + +L L+ + D LRK L + LD E S+ Q+ +
Sbjct: 1071 SQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMV 1130
Query: 60 SKSKKAQEVEVLLS-ENEMLQAKLHSQEEDFRLQNSTL---------MAEFSKERYGKEA 109
+ ++A+E+ L + E LQA L E++ + L +AE ++ +
Sbjct: 1131 EQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERV 1190
Query: 110 GKFSA------VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEE-KRLLWEQLQGLES 162
+ A + E G T+ + E+ K E E E K+ L E+ + E+
Sbjct: 1191 ARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEA 1250
Query: 163 SKQAETSRLQEELAKLSEKLKKKQE---SFCRLQTEKETLFNDSRNKIEELQ-QRKEADH 218
+ Q R + L +L+E+L++ + ++ + + E ++ R ++ LQ R+E +
Sbjct: 1251 AVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1310
Query: 219 K-----AQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQ---------- 263
+ QL Q + E A AE + Q E + AL + +
Sbjct: 1311 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1370
Query: 264 VSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAE 323
Q DAQE ++ AL + + A+E ++L ELQ QA+
Sbjct: 1371 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQ 1430
Query: 324 YEDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDEL 383
+ ++++ L+ A R + + + Q + T+ + + + + LD+
Sbjct: 1431 LSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDA 1490
Query: 384 AMETLQ--------EKSQHK-------EELGAVRLRHEKEVLGVRARYERELRELHEDKK 428
M+ Q EK Q K E+ +R E+E R ERE R L +
Sbjct: 1491 TMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGR-EREARALSLTRA 1549
Query: 429 RQEE-ELRGQI-REEKARTRELETLQQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEEL 486
+EE E R ++ R+ +A ELE L + +++ VH ++ A E+ + + EL
Sbjct: 1550 LEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTEL 1609
Query: 487 QDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQLH-LERKR 545
+D E A+ + T+ +LK + + + G+ ++ G + L +QL E +R
Sbjct: 1610 EDELTAAEDAKLRLEV---TVQALKTQHERDLQGR---DEAGEERRRQLAKQLRDAEVER 1663
Query: 546 ADKLQERLQDILTNSKSRSGLEEL 569
++ ++R + K LEEL
Sbjct: 1664 DEERKQRTLAVAARKKLEGELEEL 1687
Score = 81.6 bits (200), Expect = 2e-15
Identities = 119/563 (21%), Positives = 248/563 (44%), Gaps = 60/563 (10%)
Query: 2 AQALSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK 61
A+AL++ ++ + + L +L EL ++L RQ V+ L+K+ K + L++
Sbjct: 1459 AEALTQRLAEKTET-VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1517
Query: 62 SKKAQEVEVLLSENEMLQAKLHSQE-----------------EDFRLQNSTLMAEF---- 100
K A V + E E +A+ +E E+ QN L AE
Sbjct: 1518 EKAA--VLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALL 1575
Query: 101 -SKERYGK---EAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQ 156
SK+ GK E + V+E + + + AE + K +E + L +
Sbjct: 1576 SSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAE-DAKLRLEVTVQALKTQH 1634
Query: 157 LQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIE-ELQQRKE 215
+ L+ +A R ++ +L + ++ E + ++ TL +R K+E EL++ K
Sbjct: 1635 ERDLQGRDEAGEERRRQLAKQLRDAEVERDE-----ERKQRTLAVAARKKLEGELEELK- 1688
Query: 216 ADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQV 275
AQ+A + ++E A + L +++ Q + E R ++++ Q+ ++++++
Sbjct: 1689 ----AQMASAGQGKEE---AVKQLRKMQAQMK-ELWREVEETRTSREEIFSQNRESEKRL 1740
Query: 276 EGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLN 335
+GL AE L+ LAA ++ + Q+ + + ++ E L G+ L
Sbjct: 1741 KGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLE 1800
Query: 336 SQLQESLRANSRLL-EQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQH 394
+L+E ++NS LL ++ +++ + E LT EL R + K ++ + Q
Sbjct: 1801 EELEEE-QSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAES-----------GRQQL 1848
Query: 395 KEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQT 454
+ ++ +R R +E G RAR++ + L + EE+L + RE + + ++
Sbjct: 1849 ERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKR 1908
Query: 455 VEELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEV 514
++E+ QV +L++ + ++L + QLE+A+EE L++E+
Sbjct: 1909 LKEVVLQVEEERRVADQLRDQLEKGNLRVKQL---KRQLEEAEEEASRAQAGRRRLQREL 1965
Query: 515 KDTVDGQRILEKKGSAALKDLKR 537
+D + + ++ + L+R
Sbjct: 1966 EDVTESAESMNREVTTLRNRLRR 1988
Score = 80.9 bits (198), Expect = 3e-15
Identities = 148/675 (21%), Positives = 262/675 (38%), Gaps = 141/675 (20%)
Query: 2 AQALSEEEFQRMQAQLL-------ELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSK 54
A+A + E+ QR QA+L E + +LS EL +L ++ L +E ++
Sbjct: 1332 ARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE----LLQEETR 1387
Query: 55 AQKALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSA 114
A+ AL +A E E ++ + + LQ + + R +EAG A
Sbjct: 1388 AKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEA 1447
Query: 115 VSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEE 174
E + L + E +E+ +RL E + + E+
Sbjct: 1448 GEEARRR--AAREAEALTQRLAEKTETVDRLERGRRRLQQEL---------DDATMDLEQ 1496
Query: 175 LAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEA 234
+L L+KKQ F +L E++ +EE ++R EA+ + + AR L + LE
Sbjct: 1497 QRQLVSTLEKKQRKFDQLLAEEKAAV---LRAVEE-RERAEAEGREREARALSLTRALEE 1552
Query: 235 ANQSLAELRDQRQGERLEHAAALRALQD------------QVSIQSA-DAQEQVEGLLAE 281
++ EL Q + R E A L + D +V+ Q+A D + QV L E
Sbjct: 1553 EQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDE 1612
Query: 282 NNALRTSLAALE-QIQTAKTQELNMLR-------EQTTGLAAELQQQQAEYED------- 326
A + LE +Q KTQ L+ E+ LA +L+ + E ++
Sbjct: 1613 LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTL 1672
Query: 327 -------LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEK---- 375
L G+ ++L +Q+ + + ++QL+++ + ++L +E++E R S E+
Sbjct: 1673 AVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQ 1732
Query: 376 -----------------------------------RKAMLDELA------METLQEKSQH 394
R M DE+A L+EK Q
Sbjct: 1733 NRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL 1792
Query: 395 KEELGAVRLRHEKEVLG---VRARYERELRELH--------------------EDKKRQE 431
+ LG + E+E + RY + L ++ + +RQ
Sbjct: 1793 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1852
Query: 432 EELRGQIREEKARTRE--------LET-LQQTVEELQAQVHS--MDGAK-GWFERRLKEA 479
+ELRG++ EE A R LE+ L Q E+L+ + + G E+RLKE
Sbjct: 1853 QELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEV 1912
Query: 480 EGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALKDLKRQL 539
+ EE + V DQL E+ + +K + +E ++ + ++ L+D+
Sbjct: 1913 VLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVTESA 1972
Query: 540 HLERKRADKLQERLQ 554
+ L+ RL+
Sbjct: 1973 ESMNREVTTLRNRLR 1987
Score = 78.6 bits (192), Expect = 2e-14
Identities = 164/678 (24%), Positives = 290/678 (42%), Gaps = 116/678 (17%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELR---------KNGVELT--SLRQKVAYLDKEFSKA 55
EEE + +A + ELR + Q EL K E T +L +V+ L E S
Sbjct: 1242 EEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSL 1301
Query: 56 QKALSKSKKA--------QEVEVLLSENEMLQAKL-----HSQEEDFRLQNSTLMAEFSK 102
Q A + ++ QEV+ + E +A+ +Q E + + AE
Sbjct: 1302 QTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKT 1361
Query: 103 ERYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRL--LWEQLQGL 160
R KE A A +L A++ L + E L EQL+
Sbjct: 1362 IRLSKELSSTEAQLHD--------AQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEE 1413
Query: 161 ESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNK---IEELQQRKEAD 217
++++ LQ A+LSE ++++E L+ +E +R + L ++ E
Sbjct: 1414 AAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETV 1473
Query: 218 HKAQLARTQKLQQELEAANQSLAELRD--------QRQGERL---EHAAALRALQDQVSI 266
+ + R ++LQQEL+ A L + R QR+ ++L E AA LRA++++
Sbjct: 1474 DRLERGR-RRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEER--- 1529
Query: 267 QSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYED 326
+ + EG E AL + ALE+ Q A+ + L Q L AEL E
Sbjct: 1530 ----ERAEAEGREREARALSLT-RALEEEQEAREE----LERQNRALRAEL-------EA 1573
Query: 327 LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAME 386
L+ KDD+ + E RA R+ EQ + Q+T EL++ +AE K L+
Sbjct: 1574 LLSSKDDVGKSVHELERA-CRVAEQAAN--DLRAQVT-ELEDELTAAEDAKLRLEV---- 1625
Query: 387 TLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTR 446
T+Q A++ +HE+++ G E R+L + + E E + ++
Sbjct: 1626 TVQ----------ALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVA 1675
Query: 447 ELETLQQTVEELQAQVHSMDGAKGWFERRLK--EAEGKE-----EELQDVRDQLEQAQEE 499
+ L+ +EEL+AQ+ S K ++L+ +A+ KE EE + R+++ E
Sbjct: 1676 ARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRE 1735
Query: 500 RDCHLKTISS----LKQEVKDTVDGQRILEKK-------------GSAALKDLKRQLHLE 542
+ LK + + L++E+ + +R ++ AA+ + KRQL
Sbjct: 1736 SEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQL--- 1792
Query: 543 RKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQTGDSS-SISSFSYREILREKE 601
R +L+E L++ +NS+ + +L ++ S + + + S S + S R+ L E++
Sbjct: 1793 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQL-ERQ 1851
Query: 602 SSAVPARVRGKEEPTAPA 619
+ R+ G+E+ A A
Sbjct: 1852 IQELRGRL-GEEDAGARA 1868
Score = 75.1 bits (183), Expect = 2e-13
Identities = 97/415 (23%), Positives = 188/415 (45%), Gaps = 50/415 (12%)
Query: 242 LRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQ 301
L+ RQ E L+ A ++ QSA +++G +A+ R LA + +
Sbjct: 903 LQVTRQDEVLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCA 962
Query: 302 ELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQL------QEI 355
E R + EL+ +E E +G++++ + Q+Q + + +++L +E
Sbjct: 963 EAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEG 1022
Query: 356 GQEKEQLTQELQEAR----------------KSAEKRKAMLDELAMETLQ--EKSQHKEE 397
++K QL + EA+ K +++RK + D LA + Q E+ + +
Sbjct: 1023 ARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKS 1082
Query: 398 LGAVRLRHEKEVLGVRARYERE---LRELHEDKKR---QEEELRGQIREEKARTRELET- 450
L +RL++E + + R +E +EL + K+R + EL+ Q+ E++ R EL
Sbjct: 1083 LNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQ 1142
Query: 451 LQQTVEELQ---AQVHSMDGAKGWFERRLKEAEG----KEEELQDVRDQLEQAQEERDCH 503
L + EELQ A+ GA+ + L+EA+ +E+L+ R +A+++R
Sbjct: 1143 LGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDL 1202
Query: 504 LKTISSLKQEVKDTVD---GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNS 560
+ + +L+ E++DT+D Q+ L K + +LK+ L E + + + L
Sbjct: 1203 GEELEALRGELEDTLDSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQEL------- 1255
Query: 561 KSRSGLEELVLSEMNSPSRTQTG--DSSSISSFSYREILREKESSAVPARVRGKE 613
+ R G L+E +R G + + ++ + LR + SS AR G++
Sbjct: 1256 RQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEGEQ 1310
Score = 32.3 bits (72), Expect = 1.3
Identities = 47/247 (19%), Positives = 103/247 (41%), Gaps = 25/247 (10%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSK-SKKA 65
E +++ +L E ++N+ L+D RK +++ SL +++ +KA+ + ++
Sbjct: 1793 EGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQI 1852
Query: 66 QEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKE---AGKFSAVSEGQGDP 122
QE+ L E + A+ + L++ AE E+ +E +GK +E +
Sbjct: 1853 QELRGRLGEEDA-GARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKR--- 1908
Query: 123 PGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKL 182
L EV L + EE+R + +QL+ +L+ +L + E+
Sbjct: 1909 -------------LKEVVL----QVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEA 1951
Query: 183 KKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAEL 242
+ Q RLQ E E + + + E+ + + L T + +++ + +A
Sbjct: 1952 SRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEEGVASD 2011
Query: 243 RDQRQGE 249
+ + +
Sbjct: 2012 EEAEEAQ 2018
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 98.6 bits (244), Expect = 2e-20
Identities = 127/590 (21%), Positives = 253/590 (42%), Gaps = 90/590 (15%)
Query: 14 QAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKE----FSKAQKALSKSKKAQEVE 69
+ + +L + ++++ L + E LR K LD+E + +K ++++K+ Q+ E
Sbjct: 397 EVTIKDLESEKSRVNERLSQLEEERAFLRSKTQSLDEEQKQQILELEKKVNEAKRTQQ-E 455
Query: 70 VLLSENEMLQAKLHSQEEDFRLQNSTLMAEFS-KERYGKEAGKFSAVSEGQGDPPGGPAP 128
E + LQ++L + +S + E + K EA +A+ + +
Sbjct: 456 YYERELKNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKK-------- 507
Query: 129 TVLAPMPLAEVELKWEMEKEE-KRLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQE 187
M L E K ++ EE K L ++L+ L+ + + + +E+ L + ++K ++
Sbjct: 508 ---LQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTANQEIGHLQDMVRKSEQ 564
Query: 188 SFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQELEAANQSLAELRD--- 244
+ I LQ +E +LQ EL+ SL E +D
Sbjct: 565 GL-----------GSAEGLIASLQDSQE-----------RLQNELDLTKDSLKETKDALL 602
Query: 245 ----QRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAEN-----NALRTSLAAL-EQ 294
+ + ER +H + A++++ ++ +E EN + LR L E+
Sbjct: 603 NVEGELEQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEE 662
Query: 295 IQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQ- 353
+ + +L L+++ A + Q++ E DL+ Q L L+ L + L+QLQ
Sbjct: 663 DKKSAMSQLLQLKDREKNAARDSWQKKVE--DLLNQISLLKQNLEIQLSQSQTSLQQLQA 720
Query: 354 EIGQEKEQLTQELQEARKSAEKRKAMLDE---LAMETLQEKSQ-------------HKEE 397
+ QE+++LTQEL+E + ++R L E LA +T++E+ + H E
Sbjct: 721 QFTQERQRLTQELEELEEQHQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAE 780
Query: 398 LGAVRLRHEKEVLGVRARYERELR----ELHEDKKRQEEELRGQIREEKARTRELETLQQ 453
L +++ H + + G R E+EL+ EL ++ K LR ++ + A +L
Sbjct: 781 LQSLKDAHRESMEGFRIEMEQELQTLRFELEDEGKAMLASLRSELNHQHAAAIDL----- 835
Query: 454 TVEELQAQVH-SMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQ 512
L+ H + AK ER + + + +E L++ R+ H+ + Q
Sbjct: 836 ----LRHNHHQELAAAKMELERSIDISRRQSKEHICRITDLQEELRHREHHISELDKEVQ 891
Query: 513 EVKDTVDG-QRILEKKGSAALK---DLKRQLHLERKRADKLQERLQDILT 558
+ + + + LE KG L+ + +Q+ L + +K E+ D++T
Sbjct: 892 HLHENISALTKELEFKGKEILRIRSESNQQIRLHEQDLNKRLEKELDVMT 941
Score = 89.4 bits (220), Expect = 9e-18
Identities = 137/597 (22%), Positives = 240/597 (40%), Gaps = 82/597 (13%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
++EE R + Q+LE ++ + E R + L E Q+ ++ S++
Sbjct: 98 VTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSRE 157
Query: 65 AQEVEVLLSENEMLQAKLHSQ-EEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPP 123
+E+ E +L Q E+D RL L A +E + + Q D
Sbjct: 158 VEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRRE--------IQELLKSQQDHS 209
Query: 124 GGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEKLK 183
A V E +E R+ E L + + E +L E+ KL
Sbjct: 210 -------------ASVNKGQEKAEELHRMEVESLNKMLEELRLERKKLIEDY---EGKLN 253
Query: 184 KKQESFCRLQTEKETLFNDSRNKIEELQ--QRKEAD-------HKAQLART-QKLQQELE 233
K Q + R E +TL E LQ + KEAD +A L +T KL+ EL+
Sbjct: 254 KAQSFYER---ELDTLKRSQLFTAESLQASKEKEADLRKEFQGQEAILRKTIGKLKTELQ 310
Query: 234 AANQSLAELRDQRQGERLEHAAALRALQDQV-SIQSADAQEQVEGLLAENNALRTSLAAL 292
L D+ Q +L+ A A+ QV Q DA+E LL+++ + + LAA
Sbjct: 311 MVQDEAGSLLDKCQ--KLQTALAIAENNVQVLQKQLDDAKEGEMALLSKHKEVESELAAA 368
Query: 293 EQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQL 352
+ + +L + L A Q+ +DL +K +N +L + + L +
Sbjct: 369 RERLQQQASDLVLKASHIGMLQATQMTQEVTIKDLESEKSRVNERLSQLEEERAFLRSKT 428
Query: 353 QEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQ---------HKEELGAVRL 403
Q + +E++Q EL++ A++ + E ++ LQ + + H + L +
Sbjct: 429 QSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEEEVTQLNEAHSKTLEELAW 488
Query: 404 RHEKEVLGV-------RARYERELRELHEDKKRQEEELRGQIREEKARTRE-----LETL 451
+H + V + + + +L E H K EE + Q+++E +E L T
Sbjct: 489 KHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKLNLEEDKNQLQQELENLKEVLEDKLNTA 548
Query: 452 QQTVEELQAQVHSMDGAKGWFERRLKEAEGKEEELQD----VRDQLEQA----------- 496
Q + LQ V + G E + + +E LQ+ +D L++
Sbjct: 549 NQEIGHLQDMVRKSEQGLGSAEGLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGEL 608
Query: 497 QEERDCHLKTISSLKQEVKDTVDGQ-RILEKKGSAALKD----LKRQLHLERKRADK 548
++ER H +TI+++K+E K VD LE K + L+ L+ +L L+ + K
Sbjct: 609 EQERQQHEETIAAMKEEEKLKVDKMAHDLEIKWTENLRQECSKLREELRLQHEEDKK 665
Score = 40.4 bits (93), Expect = 0.005
Identities = 56/269 (20%), Positives = 114/269 (42%), Gaps = 32/269 (11%)
Query: 367 QEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHED 426
QE K+ A L ++ + +H+ + A++ HE+E+ + A ++ + ++
Sbjct: 38 QEMHLKMSKKIAQLTKVIYALNTKNDEHESAIQALKDAHEEEIQQILAETREKILQ-YKS 96
Query: 427 KKRQEEELRGQIRE-EKARTRELETLQQTVEELQAQVHSMDGAKGWFE-RRLKEAEGKEE 484
K +E +LR +I+ E + ++ QQ + E +A H ++ + E + ++
Sbjct: 97 KVTEELDLRRKIQVLESSLEDHIKMKQQALTEFEAYKHRVEDMQLCAEAQHVQRIVTMSR 156
Query: 485 ELQDVRDQLE---------QAQEERD----------CHLKTISSLKQEVKD----TVDGQ 521
E++++R + E Q Q E+D H + I L + +D GQ
Sbjct: 157 EVEEIRRKFEEKLRSFGQLQVQFEKDKRLALEDLQAAHRREIQELLKSQQDHSASVNKGQ 216
Query: 522 RILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ 581
E+ ++ L + L R KL E + L +K++S E E+++ R+Q
Sbjct: 217 EKAEELHRMEVESLNKMLEELRLERKKLIEDYEGKL--NKAQSFYER----ELDTLKRSQ 270
Query: 582 TGDSSSISSFSYREILREKESSAVPARVR 610
+ S+ + +E KE A +R
Sbjct: 271 LFTAESLQASKEKEADLRKEFQGQEAILR 299
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 97.8 bits (242), Expect = 3e-20
Identities = 127/598 (21%), Positives = 260/598 (43%), Gaps = 45/598 (7%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK-KA 65
EE + A LEL N ++EL+K EL ++K+ + E S+ Q + + K K
Sbjct: 200 EELTKERDALSLELYRNTIT-NEELKKKNAEL---QEKLPLAESEKSEIQLNVKELKRKL 255
Query: 66 QEVEVLLSE--NEMLQAKLHSQEEDFRLQNSTLMAEFSK-----ERYGKEAGKFSAVSEG 118
+ + LL + LQ ++ QEE+ R Q + + K ER ++ GK E
Sbjct: 256 ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEK 315
Query: 119 ----------QGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAET 168
Q + L E E E +E++ +WEQ + + +Q E
Sbjct: 316 MWRQEKRLREQEKELREQEKELREQKELREQE---EQMQEQEEKMWEQEEKMR--EQEEK 370
Query: 169 SRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDS-RNKIEELQQRKEADHKAQLARTQK 227
QEE EK ++QE R Q E+ ++ R K E ++++++ + + R +K
Sbjct: 371 MWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEK 430
Query: 228 LQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRT 287
QE E + E + + R E +R ++ + Q Q+Q E + +
Sbjct: 431 KMQEQEKKTRDQEEKMQEEERIR-EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ 489
Query: 288 SLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEY---EDLMGQKDDLNSQLQESLRA 344
EQ + QE +E+ E + Q E E M +++ + Q +
Sbjct: 490 QQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQ 549
Query: 345 NSRLLEQLQEIGQEKEQLTQELQEARKSA-EKRKAMLDELAMETLQEKSQHKEELGAVRL 403
++ +Q Q++ ++E++ ++ QE K ++ + M +E M ++K + +EE+ +
Sbjct: 550 EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEM----M 605
Query: 404 RHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVH 463
R ++E + E+E + +++K E+E + Q +EEK +E + +Q + + Q
Sbjct: 606 REQEEKM-----QEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL 660
Query: 464 SMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRI 523
K W +++E E +E+ + + +Q + ++ ++ KT K ++++ R
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESM---RE 717
Query: 524 LEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNSPSRTQ 581
EKK + ++ Q +++ +K+QE+ +++ + EE + + P + +
Sbjct: 718 REKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775
Score = 92.4 bits (228), Expect = 1e-18
Identities = 121/637 (18%), Positives = 267/637 (41%), Gaps = 110/637 (17%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKAL-SKSKKA 65
EEE + + ++ + ++ + LR+ ++ +K+ +K + +K L + K+
Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337
Query: 66 QEVEVLLSENEMLQA---KLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDP 122
+E + L + E +Q K+ QEE R Q + + +ER ++ + + D
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ--EERLWEQEKQMREQEQKMRD- 394
Query: 123 PGGPAPTVLAPMPLAEVELKWEM-----EKEEK----RLLWEQLQGLESSK----QAETS 169
+ E WE EKEE+ +WEQ++ + K Q + +
Sbjct: 395 ---------------QEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 170 RLQEELAKLSEKL----KKKQESFCRLQTEKETLFNDSRNKIE----ELQQRKEADHKAQ 221
R QEE + E++ KK +E ++ ++E + N E E QQ++ + K +
Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK 499
Query: 222 LARTQKLQQELEAANQSLAELRDQR----QGERLEHAAALRALQDQVSIQSADAQEQVEG 277
L +K+Q++ E + ++RDQ Q +++ +R +DQ+ Q ++Q +
Sbjct: 500 LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK 559
Query: 278 LLAENNALRTSLAALEQI---QTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDL 334
+ + + E+ Q K +E +RE+ + E + + + E + Q++ +
Sbjct: 560 MWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 619
Query: 335 NSQLQESLRANSRLLEQLQEIGQEKEQL---------TQELQEARKSAEKRKAMLDELAM 385
Q ++ ++ EQ +++ +++E++ Q L E ++ + + M ++ M
Sbjct: 620 QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKM 679
Query: 386 ETLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKART 445
+ +EK +E++ EK+ E E E K R+EEE+ + +EEK +
Sbjct: 680 QEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMRE-QEEKMQE 738
Query: 446 RELETLQQTVEELQAQVHSM--DGAKGWFERRLKEAE----------------------- 480
+E E +Q+ EE+ Q M K W ++RL E +
Sbjct: 739 QE-EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMR 797
Query: 481 ---------------------GKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVD 519
G+EE++ +++ +E+ + + ++++++ +
Sbjct: 798 DQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQ 857
Query: 520 GQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDI 556
GQ E+K + ++ Q R++ +K++ + + I
Sbjct: 858 GQ---EEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
Score = 87.0 bits (214), Expect = 5e-17
Identities = 118/479 (24%), Positives = 215/479 (44%), Gaps = 67/479 (13%)
Query: 50 KEFSKA----QKALSKSKKAQE--VEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKE 103
KE KA Q+AL + +AQ+ + +L + L+ L+ ++ R +F
Sbjct: 80 KEEKKASHQHQEALRREIEAQDHTIRILTCQKTELETALYYSQDAAR--------KFEDG 131
Query: 104 RYGKEAGKFSAVSEGQGDPPGGPAPTVLAPMPLAEVELK----WEMEKEEKRLLWEQLQG 159
G + A+S+ P G T L P ++ + W E +R L
Sbjct: 132 NLGTPSSFNLALSQAFRGSPLGCVSTSLIPGESKDLAGRLHHSWHFAGELQRAL-----S 186
Query: 160 LESSKQAETSRLQEELAK--------------LSEKLKKKQESFCRLQTEKETLFNDSRN 205
S++ + R EEL K +E+LKKK E+ ++ +
Sbjct: 187 AVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQL 246
Query: 206 KIEELQQRKE-ADHKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQV 264
++EL+++ E A +T LQ+E+ + ELR+Q + R + R ++++
Sbjct: 247 NVKELKRKLERAKFLLPQVQTNTLQEEMWRQEE---ELREQEKKIRKQEEKMWRQ-EERL 302
Query: 265 SIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEY 324
Q +EQ E + + LR L + Q + +E LREQ +Q Q +
Sbjct: 303 REQEGKMREQEEKMWRQEKRLREQEKELRE-QEKELREQKELREQE-------EQMQEQE 354
Query: 325 EDLMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELA 384
E + Q++ + Q ++ R RL EQ +++ +E+EQ ++ +E ++R +E
Sbjct: 355 EKMWEQEEKMREQEEKMWRQEERLWEQEKQM-REQEQKMRDQEERMWEQDERLREKEERM 413
Query: 385 METLQEKSQHKEELGAVRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKAR 444
E QEK + E ++R EK++ E+E + +++K QEEE R + RE+K R
Sbjct: 414 RE--QEKMWEQVE----KMREEKKM------QEQEKKTRDQEEKMQEEE-RIREREKKMR 460
Query: 445 TRELETLQQTVEELQAQVHSM--DGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERD 501
E ET+++ E++Q Q +M K W ++RL E + K E + +++Q E+ E+ +
Sbjct: 461 EEE-ETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 518
Score = 64.7 bits (156), Expect = 2e-10
Identities = 80/339 (23%), Positives = 161/339 (47%), Gaps = 60/339 (17%)
Query: 250 RLEH----AAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNM 305
RL H A L+ VS + A +E L E +AL +LE + T E
Sbjct: 170 RLHHSWHFAGELQRALSAVSTRHKKADRYIEELTKERDAL-----SLELYRNTITNE--- 221
Query: 306 LREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQL------------- 352
EL+++ AE ++ + + S++Q +++ R LE+
Sbjct: 222 ----------ELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQ 271
Query: 353 QEIGQEKEQLTQELQEARKSAEKRKAMLDELA-----METLQEKSQHKEELGAVRLRHEK 407
+E+ +++E+L ++ ++ RK EK + L M +EK +E+ RLR ++
Sbjct: 272 EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK----RLREQE 327
Query: 408 EVLGVRARYERELRELHEDKKR-QEEELRGQIREEKART------RELETLQQTVEELQA 460
+ L + + RE +EL E +++ QE+E + +EEK R R+ E L + ++++
Sbjct: 328 KELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE 387
Query: 461 QVHSM-DGAKGWFER--RLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDT 517
Q M D + +E+ RL+E E + E + + +Q+E+ +EE+ + + QE K
Sbjct: 388 QEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEK-M 446
Query: 518 VDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDI 556
+ +RI E++ K ++ + R++ +K+Q++ +++
Sbjct: 447 QEEERIRERE-----KKMREEEETMREQEEKMQKQEENM 480
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 97.4 bits (241), Expect = 3e-20
Identities = 150/704 (21%), Positives = 302/704 (42%), Gaps = 123/704 (17%)
Query: 1 MAQALSEEEFQRMQAQLL--ELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKA 58
+ + L EE QR + + +L ++ LSD++ + ++ L+ ++A ++E Q A
Sbjct: 1032 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEEL---QAA 1088
Query: 59 LSK-SKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTL-MAEFSKERYGKEAGKFSAVS 116
L++ ++A + + L + L++++ +ED + ++ AE K G+E
Sbjct: 1089 LARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148
Query: 117 EGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEE---KRLLWEQLQGLESSKQAETSRLQE 173
E D A+ EL+ + E+E K+ L E+ + E+ Q + +
Sbjct: 1149 EDTLDSTA------------AQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ 1196
Query: 174 ELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEE----LQQRKEADHKAQL--ARTQK 227
+ +L+E+L++ + L+ K+TL N+ E LQ + +++HK + A+ Q+
Sbjct: 1197 AVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE 1256
Query: 228 LQQELEAANQSLAELRDQ--RQGERLEHAAALRALQDQVS------IQSADAQEQ-VEGL 278
LQ + + EL D+ + L++ L + D S + ++Q Q + L
Sbjct: 1257 LQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQEL 1316
Query: 279 LAENNALRTSLAA-LEQIQTAKTQELNMLRE----------QTTGLAAELQQQQAEYEDL 327
L E N + SL+ L+Q++ K L E Q L A++ + + ED
Sbjct: 1317 LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS 1376
Query: 328 MG------------QKD--DLNSQLQESLRANSRLLEQLQEIGQEKEQLTQELQEARKSA 373
+G QKD L+ + +E + A +L + + QE + L +L R+SA
Sbjct: 1377 VGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436
Query: 374 ---EKRKAMLDELAMET-------------LQEKSQHKEELGAVRLRHEKEVLGVRARYE 417
EK++ D+L E + +++ KE R +E + +A E
Sbjct: 1437 CNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE 1496
Query: 418 R-------ELRELHEDK----------KRQEEELRGQIREEKARTRELETLQQTVEELQA 460
R E+ +L K ++ + L Q+ E K + ELE Q E+ +
Sbjct: 1497 RLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKL 1556
Query: 461 QVH-SMDGAKGWFERRLKEAEGKEEE-----LQDVRD---QLEQAQEERDCHLKTISSLK 511
++ ++ K FER L+ + + EE ++ VR+ +LE +++R + L+
Sbjct: 1557 RLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLE 1616
Query: 512 QEVKDTVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTN-SKSRSGLEELV 570
++KD K A+K L+ KLQ +++D + +R+ EE++
Sbjct: 1617 MDLKDLEAHIDSANKNRDEAIKQLR-----------KLQAQMKDCMRELDDTRASREEIL 1665
Query: 571 LSEMNSPSRTQTGDSSSISSFSYREILREKESSAVPARVRGKEE 614
+ + ++ ++ I L+E+ ++A A+ + ++E
Sbjct: 1666 AQAKENEKKLKSMEAEMIQ-------LQEELAAAERAKRQAQQE 1702
Score = 97.1 bits (240), Expect = 4e-20
Identities = 141/600 (23%), Positives = 265/600 (44%), Gaps = 81/600 (13%)
Query: 5 LSEEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKK 64
L+ + F + Q QL ++ L++N LR + + F+K + L S+
Sbjct: 794 LARKAFAKRQQQLTAMKV--------LQRNCAAYLKLRNWQWW--RLFTKVKPLLQVSR- 842
Query: 65 AQEVEVLLSENEMLQAKLHSQEEDFRL-QNSTLMAEFSKERYGKEAGKFSAVSEGQGDPP 123
QE E++ E E+++ + + RL + TL ++ E+ + + A +E +
Sbjct: 843 -QEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQE-QLQAETELCAEAE 900
Query: 124 GGPAPTVLAPMPLAEV--ELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELAKLSEK 181
A L E+ +L+ +E+EE+R QAE ++Q+ + +L E+
Sbjct: 901 ELRARLTAKKQELEEICHDLEARVEEEEERC---------QHLQAEKKKMQQNIQELEEQ 951
Query: 182 LKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADHKAQLARTQKLQQ----------- 230
L++++ + +LQ EK T K+EE Q E D +LA+ +KL +
Sbjct: 952 LEEEESARQKLQLEKVTT-EAKLKKLEEEQIILE-DQNCKLAKEKKLLEDRIAEFTTNLT 1009
Query: 231 ELEAANQSLAELRDQRQG------ERL----EHAAALRALQDQVSIQSADAQEQVEGLLA 280
E E ++SLA+L+++ + ERL + L + ++ S D +Q+ L A
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA 1069
Query: 281 ENNALRTSLAALEQIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQE 340
+ L+ LA K +EL + AA+ + +L Q +L L+
Sbjct: 1070 QIAELKMQLA-------KKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES 1122
Query: 341 SLRANSRLLEQLQEIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGA 400
+ ++ +Q +++G+E E L EL++ S ++ + +S+ ++E+
Sbjct: 1123 ERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL-----------RSKREQEVNI 1171
Query: 401 VRLRHEKEVLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVE---- 456
++ E+E +E +++E+ + + EEL Q+ + K LE +QT+E
Sbjct: 1172 LKKTLEEEA----KTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERG 1227
Query: 457 ELQAQVHSMDGAKGWFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKD 516
EL +V + KG E + K+ E + +ELQ ++ E+ + E ++ L+ E+ D
Sbjct: 1228 ELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTEL---ADKVTKLQVEL-D 1283
Query: 517 TVDGQRILEKKGSAALKDLKRQLHLERKRADKLQERLQDILTNSKSRSGLEELVLSEMNS 576
V G +L + S + K K LE + D QE LQ+ S S + V E NS
Sbjct: 1284 NVTG--LLSQSDSKSSKLTKDFSALESQLQD-TQELLQEENRQKLSLSTKLKQVEDEKNS 1340
Score = 87.8 bits (216), Expect = 3e-17
Identities = 103/544 (18%), Positives = 229/544 (42%), Gaps = 55/544 (10%)
Query: 19 ELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSK--------------- 63
+L +L EL V+L RQ L+K+ K + L++ K
Sbjct: 1410 KLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEA 1469
Query: 64 -------KAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVS 116
KA + L E +A+L + FR + LM+ SK+ GK +
Sbjct: 1470 EAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMS--SKDDVGKSVHELEKSK 1527
Query: 117 EGQGDPPGGPAPTVLAPMPLAEVELKWEMEKEEKRLLWEQLQGLESSKQAETSRLQEELA 176
+ E++ + E ++E + + LE + QA ++ + +L
Sbjct: 1528 RA-------------LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQ 1574
Query: 177 KLSEKLKKKQESFCRLQTEKETLFNDSRNKIE---ELQQRKEADHKAQLARTQKLQQELE 233
E+ ++K++ R E E D R + +++ E D K A + +
Sbjct: 1575 GRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD 1634
Query: 234 AANQSLAELRDQRQGERLEHAAALRALQDQVSIQSADAQEQVEGLLAENNALRTSLAALE 293
A + L +L+ Q + + + RA ++++ Q+ + +++++ + AE L+ LAA E
Sbjct: 1635 EAIKQLRKLQAQMK-DCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE 1693
Query: 294 QIQTAKTQELNMLREQTTGLAAELQQQQAEYEDLMGQKDDLNSQLQESLRANSRLLEQLQ 353
+ + QE + L ++ + + E L + L +L+E + ++L+
Sbjct: 1694 RAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK 1753
Query: 354 EIGQEKEQLTQELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRLRHEKEVLGVR 413
+ + +Q+ +L R A+K + +L + + K + +E G V+ +++ + +
Sbjct: 1754 KANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALE 1813
Query: 414 ARYERELRELHEDKKRQEEELRGQIREEKARTRELETLQQTVEELQAQVHSMDGAKGWFE 473
A+ + EE+L + +E +A +++ ++ ++++ QV D + E
Sbjct: 1814 AKI-----------AQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQV---DDERRNAE 1859
Query: 474 RRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSAALK 533
+ +A+ L+ ++ QLE+A+EE + L++E++D + + ++ S+
Sbjct: 1860 QYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKN 1919
Query: 534 DLKR 537
L+R
Sbjct: 1920 KLRR 1923
Score = 86.7 bits (213), Expect = 6e-17
Identities = 138/646 (21%), Positives = 264/646 (40%), Gaps = 112/646 (17%)
Query: 7 EEEFQRMQAQLLELRTNNYQLSDELRKNGVELTSLRQKVAYLDKEFSKAQKALSKSKKAQ 66
EE Q +QA+ +++ N +L ++L E S RQK+ L+K ++A K KK +
Sbjct: 928 EERCQHLQAEKKKMQQNIQELEEQLE----EEESARQKLQ-LEKVTTEA-----KLKKLE 977
Query: 67 EVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKERYGKEAGKFSAVSEGQGDPPGGP 126
E +++L + AK ED + +T + E +E K K E
Sbjct: 978 EEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTE--EEEKSKSLAKLKNKHEAM------- 1028
Query: 127 APTVLAPMPLAEVELKWEMEKEEKRL--------------------LWEQLQGLESSKQA 166
T L E + + E+EK ++L L QL E QA
Sbjct: 1029 -ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQA 1087
Query: 167 ETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFND--SRNKIEELQQRKEADHKAQLAR 224
+R++EE A+ + LKK +E ++ +E L ++ SRNK E+ Q+++ + + +
Sbjct: 1088 ALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEK--QKRDLGEELEALK 1145
Query: 225 TQKLQQELE--AANQSLAELRDQR--------QGERLEHAAALRALQDQVSIQSADAQEQ 274
T+ L+ L+ AA Q L R+Q + E H A ++ ++ + S + EQ
Sbjct: 1146 TE-LEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ 1204
Query: 275 VEGLLAENNALRTSLAALEQIQTAKTQELNMLRE-------QTTGLAAELQQQQAEYED- 326
+E L + LE + E+ +L + + + A+LQ+ Q ++ +
Sbjct: 1205 LEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEG 1264
Query: 327 -----------------------LMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLT 363
L+ Q D +S+L + A L+ QE+ QE+ +
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 364 QELQEARKSAEKRKAMLDELAMETLQEKSQHKEELGAVRL------RHEKEVLGVRARYE 417
L K E K E E + K ++++ + + ++ +G E
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE 1384
Query: 418 RELRELHED----KKRQEEELRGQIREEKARTR---ELETLQQTVEELQAQVHSMDGAKG 470
R+L +D +R EE++ + EK +TR EL+ L ++ + +++ +
Sbjct: 1385 EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQK 1444
Query: 471 WFERRLKEAEGKEEELQDVRDQLEQAQEERDCHLKTISSLKQEVKDTVDGQRILEKKGSA 530
F++ L E + + + RD+ E E++ +++ +E + L K+
Sbjct: 1445 KFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRT 1504
Query: 531 ALKDLK-------RQLHLERKRADKLQERLQDILTNSKSRSGLEEL 569
++DL + +H K L+++++++ T LEEL
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ------LEEL 1544
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.123 0.312
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,457,268
Number of Sequences: 37866
Number of extensions: 1074419
Number of successful extensions: 28283
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 606
Number of HSP's successfully gapped in prelim test: 1405
Number of HSP's that attempted gapping in prelim test: 7627
Number of HSP's gapped (non-prelim): 7756
length of query: 625
length of database: 18,247,518
effective HSP length: 108
effective length of query: 517
effective length of database: 14,157,990
effective search space: 7319680830
effective search space used: 7319680830
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.