Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 13236530
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
[Homo sapiens]
(520 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ... 1092 0.0
gi|73808271 matrix metalloproteinase 28 isoform 3 [Homo sapiens] 256 4e-68
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot... 256 5e-68
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens] 246 4e-65
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ... 244 2e-64
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens] 236 3e-62
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens] 233 2e-61
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap... 216 3e-56
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi... 211 2e-54
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi... 207 2e-53
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H... 201 1e-51
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein... 193 3e-49
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens] 193 4e-49
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens] 191 2e-48
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi... 190 2e-48
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens] 188 1e-47
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi... 188 1e-47
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens] 187 3e-47
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens] 172 7e-43
gi|73808268 matrix metalloproteinase 27 [Homo sapiens] 153 4e-37
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi... 138 1e-32
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens] 133 3e-31
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi... 131 1e-30
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens] 111 2e-24
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens] 102 6e-22
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [... 102 6e-22
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ... 102 1e-21
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens] 100 3e-21
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens] 52 2e-06
gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens] 52 2e-06
>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
[Homo sapiens]
Length = 520
Score = 1092 bits (2824), Expect = 0.0
Identities = 520/520 (100%), Positives = 520/520 (100%)
Query: 1 MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFS 60
MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFS
Sbjct: 1 MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFS 60
Query: 61 DAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRK 120
DAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRK
Sbjct: 61 DAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRK 120
Query: 121 KRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPAD 180
KRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPAD
Sbjct: 121 KRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPAD 180
Query: 181 IRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEAHFDQDERWSLSRRRGRNLFVVLAH 240
IRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEAHFDQDERWSLSRRRGRNLFVVLAH
Sbjct: 181 IRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEAHFDQDERWSLSRRRGRNLFVVLAH 240
Query: 241 EIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLF 300
EIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLF
Sbjct: 241 EIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLF 300
Query: 301 TDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPR 360
TDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPR
Sbjct: 301 TDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPR 360
Query: 361 PLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHPDA 420
PLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHPDA
Sbjct: 361 PLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHPDA 420
Query: 421 ALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSIIFF 480
ALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSIIFF
Sbjct: 421 ALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSIIFF 480
Query: 481 RDDRYWRLDQAKLQATTSGRWATELPWMGCWHANSGSALF 520
RDDRYWRLDQAKLQATTSGRWATELPWMGCWHANSGSALF
Sbjct: 481 RDDRYWRLDQAKLQATTSGRWATELPWMGCWHANSGSALF 520
>gi|73808271 matrix metalloproteinase 28 isoform 3 [Homo sapiens]
Length = 130
Score = 256 bits (654), Expect = 4e-68
Identities = 127/127 (100%), Positives = 127/127 (100%)
Query: 1 MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFS 60
MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFS
Sbjct: 1 MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFS 60
Query: 61 DAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRK 120
DAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRK
Sbjct: 61 DAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRK 120
Query: 121 KRFAKQG 127
KRFAKQG
Sbjct: 121 KRFAKQG 127
>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
[Homo sapiens]
Length = 508
Score = 256 bits (653), Expect = 5e-68
Identities = 167/458 (36%), Positives = 240/458 (52%), Gaps = 41/458 (8%)
Query: 39 FLEKYGYLNEQVPKAPT--STRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDT 96
+L +YGYL + + + ++A+RAFQ S+LPVSG LD AT +M +PRCG+ D
Sbjct: 31 YLSQYGYLQKPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLEDP 90
Query: 97 NSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVR 156
+ ++ ++ G +W K+HL++R++N P LP R A+R
Sbjct: 91 FN-------------------QKTLKYLLLG-RWRKKHLTFRILNLPSTLPPHTARAALR 130
Query: 157 AAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEA 216
AFQ WSNV+ L F E A G ADIRL+F G + N FDGPG LAHA +P G
Sbjct: 131 QAFQDWSNVAPLTFQEVQA-GAADIRLSF-HGRQSSYCSNTFDGPGRVLAHADIPELGSV 188
Query: 217 HFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDV 276
HFD+DE W+ RG NL ++ AHE+GH LGL HS +ALMAP Y+ L DDV
Sbjct: 189 HFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPHFKLHPDDV 248
Query: 277 LAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQ 336
+Q+LYGK S ++ + T+ T P P P C S DA+ + +
Sbjct: 249 AGIQALYGKK---SPVIRDEEEEETELPT---VPPVPTEPSPM-PDPCSSELDAMMLGPR 301
Query: 337 QQLYIFKGSHFWEVAADGNVSEPRPL---QERWVGLPPNIEAAAVSLNDGDFYFFKGGRC 393
+ Y FKG + W V+ G P PL W GLP N++AA S +FFKG +
Sbjct: 302 GKTYAFKGDYVWTVSDSG----PGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKV 357
Query: 394 WRFRGPKPVWGLPQLCRAGGLPRHPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYP 453
WR+ K G P+ + + + DAAL++P +++ LFKG+ Y+ YP
Sbjct: 358 WRYINFKMSPGFPK--KLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYP 415
Query: 454 RSLQD-WGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQ 490
+ ++ + G+P + S A+ DG + FF+ YWRL+Q
Sbjct: 416 KPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQ 453
>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
Length = 645
Score = 246 bits (628), Expect = 4e-65
Identities = 171/516 (33%), Positives = 244/516 (47%), Gaps = 60/516 (11%)
Query: 35 EAEA------FLEKYGYL---NEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQ 85
EAEA +L+ YGYL + + ++ A+ Q +PV+GVLD+ T+
Sbjct: 74 EAEAPFAGQNWLKSYGYLLPYDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEW 133
Query: 86 MTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEH 145
M +PRCGV D H ++ RR KR+A G KW ++H++Y + N+
Sbjct: 134 MKKPRCGVPDHP---------------HLSRRRRNKRYALTGQKWRQKHITYSIHNYTPK 178
Query: 146 LPEPAVRGAVRAAFQLWSNVSALEFWEAP------ATGPADIRLTFFQGDHNDGLGNAFD 199
+ E R A+R AF +W V+ L F E P ADI + F G H D + FD
Sbjct: 179 VGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGD--SSPFD 236
Query: 200 GPGGALAHAFLPR---RGEAHFDQDERWSL--SRRRGRNLFVVLAHEIGHTLGLTHSPAP 254
G GG LAHA+ P G+ HFD DE W+L + G +LF+V HE+GH LGL HS P
Sbjct: 237 GEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDP 296
Query: 255 RALMAPYYKRL-GRDALLSWDDVLAVQSLYGKPLGGSV-----------AVQLPGKLFTD 302
A+MAP+Y+ + + L DD+ +Q +YG P + P + +
Sbjct: 297 SAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHE 356
Query: 303 FETWDSYSPQGRRPETQG--PKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPR 360
+ P G RP T G P C +F+ + + R ++++FK FW + + V E
Sbjct: 357 RQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFR-GEMFVFKDRWFWRL-RNNRVQEGY 414
Query: 361 PLQ--ERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGG--LPR 416
P+Q + W GLP I+ AA DG F FFKG + W F+ G P G LPR
Sbjct: 415 PMQIEQFWKGLPARID-AAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPR 473
Query: 417 HP-DAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDG 475
D AL + P+ + FKG RY+ + +P YP+ + W GIP+ GA +G
Sbjct: 474 EGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEG 533
Query: 476 SIIFFRDDR-YWRLDQAKLQATTSGRWATELPWMGC 510
+F R YW+ D KL WMGC
Sbjct: 534 YYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGC 569
>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
[Homo sapiens]
Length = 607
Score = 244 bits (622), Expect = 2e-64
Identities = 170/533 (31%), Positives = 257/533 (48%), Gaps = 57/533 (10%)
Query: 12 LQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAP---TSTRFSDAIRAFQW 68
LQ LLW A G E E +L+KYGYL P+ ++ A+ A Q
Sbjct: 23 LQTLLW----ILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQ 78
Query: 69 VSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMR-RKKRFAKQG 127
+ ++G +DR T+ M +PRCGV D R +K R+KR+A G
Sbjct: 79 FYGINMTGKVDRNTIDWMKKPRCGVPDQT--------------RGSSKFHIRRKRYALTG 124
Query: 128 NKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAP------ATGPADI 181
KW +H++Y + N + +P R A+R AF +W NV+ L F E P DI
Sbjct: 125 QKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDI 184
Query: 182 RLTFFQGDHNDGLGNAFDGPGGALAHAFLPR---RGEAHFDQDERWSLS--RRRGRNLFV 236
+ F G H D + FDG GG LAHA+ P G+ HFD DE W+L G +LF+
Sbjct: 185 TIIFASGFHGD--SSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFL 242
Query: 237 VLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDAL-LSWDDVLAVQSLYG-----KPLGGS 290
V HE+GH LGL HS P A+MAP+Y+ + D L DD+ +Q +YG P
Sbjct: 243 VAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRP 302
Query: 291 VAVQLPGKLFTDFETWDSYSPQGRRPETQGPKY-------CHSSFDAITVDRQQQLYIFK 343
+ P + + + P+ RP T P Y C +F+ + + R +++++FK
Sbjct: 303 LPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILR-REMFVFK 361
Query: 344 GSHFWEVAADGNVSEPRPLQER--WVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKP 401
FW V + V + P+Q W GLPP+I+A + +DG+F FFKG + W F+
Sbjct: 362 DQWFWRV-RNNRVMDGYPMQITYFWRGLPPSIDAVYEN-SDGNFVFFKGNKYWVFKDTTL 419
Query: 402 VWGLPQ--LCRAGGLPRHP-DAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQD 458
G P + G+P H D+A+++ + + FKG RY+ + ++P YP+ +
Sbjct: 420 QPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITV 479
Query: 459 WGGIPEEVSGA-LPRPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWMGC 510
W GIPE GA + + +G F++ YW+ + L+ + +MGC
Sbjct: 480 WKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGC 532
>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
Length = 669
Score = 236 bits (603), Expect = 3e-62
Identities = 182/551 (33%), Positives = 245/551 (44%), Gaps = 69/551 (12%)
Query: 9 LRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFS-----DAI 63
L L L+L G L A ++ AE +L YGYL + P ST S A+
Sbjct: 29 LLPLLLVLLGCLGLGVA---AEDAEVHAENWLRLYGYLPQ--PSRHMSTMRSAQILASAL 83
Query: 64 RAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRF 123
Q +PV+GVLD T M RPRCGV D A RR+KR+
Sbjct: 84 AEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANL-----------RRRRKRY 132
Query: 124 AKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATG------ 177
A G KW HL++ + N+ E L AVR AF++W + L F E P
Sbjct: 133 ALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQ 192
Query: 178 -PADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRG---EAHFDQDERWSLSRR--RG 231
ADI + F G H D + FDG GG LAHA+ P G + HFD DE W+ S G
Sbjct: 193 KEADIMVLFASGFHGDS--SPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHG 250
Query: 232 RNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDAL-LSWDDVLAVQSLYGKPLG-- 288
NLF+V HE+GH LGL HS P A+MAP+Y+ D L DD+ +Q LYG P G
Sbjct: 251 NNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQP 310
Query: 289 ------GSVAVQLPGKLFTDFETWDSYSPQG------------------RRPETQGPKYC 324
+V + PG+ P G RP+ GP C
Sbjct: 311 QPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNIC 370
Query: 325 HSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSE-PRPLQERWVGLPPNIEAAAVSLNDG 383
FD + + R ++++FKG FW V + + P P+ W GLP +I +AA DG
Sbjct: 371 DGDFDTVAMLR-GEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDI-SAAYERQDG 428
Query: 384 DFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLP---RHPDAALFFPPLRRLILFKGARYYV 440
F FFKG R W FR G PQ + GL D A+++ P F+ RY+
Sbjct: 429 RFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWR 488
Query: 441 LARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGS-IIFFRDDRYWRLDQAKLQATTSG 499
+ +P YP+ + W GIP GA D + F++ +YW+ D +L+
Sbjct: 489 FNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGY 548
Query: 500 RWATELPWMGC 510
+ +MGC
Sbjct: 549 PKSILRDFMGC 559
>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
Length = 582
Score = 233 bits (595), Expect = 2e-61
Identities = 165/498 (33%), Positives = 238/498 (47%), Gaps = 49/498 (9%)
Query: 37 EAFLEKYGYL-----NEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRC 91
EA+L++YGYL ++P S S AI A Q L V+G D T++ M RPRC
Sbjct: 36 EAWLQQYGYLPPGDLRTHTQRSPQS--LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRC 93
Query: 92 GVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAV 151
GV D F R+KR+A QG KW +++ + N+ + E A
Sbjct: 94 GVPDK-------------FGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYAT 140
Query: 152 RGAVRAAFQLWSNVSALEFWEAPAT-------GPADIRLTFFQGDHNDGLGNAFDGPGGA 204
A+R AF++W + + L F E P ADI + F +G H D FDG GG
Sbjct: 141 YEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDS--TPFDGEGGF 198
Query: 205 LAHAFLPRR---GEAHFDQDERWSLSRR--RGRNLFVVLAHEIGHTLGLTHSPAPRALMA 259
LAHA+ P G+ HFD E W++ G ++F+V HE+GH LGL HS P A+MA
Sbjct: 199 LAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMA 258
Query: 260 PYYKRLG-RDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYS-PQGRRPE 317
P+Y+ + + +L DD +Q LYG G P K+ T S P +
Sbjct: 259 PFYQWMDTENFVLPDDDRRGIQQLYGGESG------FPTKMPPQPRTTSRPSVPDKPKNP 312
Query: 318 TQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNV-SEPRPLQERWVGLPPNIEAA 376
T GP C +FD + + R ++++FK FW V + + P P+ + W GLP +I
Sbjct: 313 TYGPNICDGNFDTVAMLR-GEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASIN-T 370
Query: 377 AVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCR--AGGLPRHP-DAALFFPPLRRLILF 433
A DG F FFKG + W F G P+ + GLP DAALF+ P + F
Sbjct: 371 AYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFF 430
Query: 434 KGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSI-IFFRDDRYWRLDQAK 492
+G +YY V+ YP++++ W GIPE G+ D F++ ++YW+ + K
Sbjct: 431 RGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQK 490
Query: 493 LQATTSGRWATELPWMGC 510
L+ + WMGC
Sbjct: 491 LKVEPGYPKSALRDWMGC 508
>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
sapiens]
Length = 603
Score = 216 bits (551), Expect = 3e-56
Identities = 158/492 (32%), Positives = 225/492 (45%), Gaps = 43/492 (8%)
Query: 39 FLEKYGYLNEQVP---KAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTD 95
+L ++GYL P + T S AI A Q L +G+LD ATL M PRC + D
Sbjct: 55 WLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPD 114
Query: 96 TNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLP--EPAVRG 153
R++R A KW K++LS+R+ +P P VR
Sbjct: 115 LPVLT----------------QARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRA 158
Query: 154 AVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRR 213
+ A ++WS+++ L F E A ADI++ F + DHNDG FDGPGG +AHAF P
Sbjct: 159 LMYYALKVWSDIAPLNFHEV-AGSAADIQIDFSKADHNDGY--PFDGPGGTVAHAFFPGH 215
Query: 214 ----GEAHFDQDERWSL--SRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGR 267
G+ HFD DE W+ S G +LF V HE GH +GL+H A ++M PYY+
Sbjct: 216 HHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVG 275
Query: 268 DAL---LSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYC 324
D L L ++D + V LYG S Q P + E D+ S R + P C
Sbjct: 276 DPLRYGLPYEDKVRVWQLYGVRESVSPTAQ-PEEPPLLPEPPDNRSSAPPRKDV--PHRC 332
Query: 325 HSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQER--WVGLP---PNIEAAAVS 379
+ FDA+ R + + FKG +FW + D ++ +P Q W GLP +++A
Sbjct: 333 STHFDAVAQIRGEAFF-FKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYER 391
Query: 380 LNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHP-DAALFFPPLRRLILFKGARY 438
+D FFKG R W F+ G P+ LP DAA + R FK Y
Sbjct: 392 TSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPPGGIDAAFSWAHNDRTYFFKDQLY 451
Query: 439 YVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTS 498
+ ++P YP W G+P + A+ DG+ FFR YW++ +L+
Sbjct: 452 WRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPG 511
Query: 499 GRWATELPWMGC 510
+T W+ C
Sbjct: 512 YPQSTARDWLVC 523
>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
sapiens]
Length = 488
Score = 211 bits (536), Expect = 2e-54
Identities = 151/440 (34%), Positives = 208/440 (47%), Gaps = 37/440 (8%)
Query: 68 WVSQLPVSGVLDRATLR------QMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKK 121
W + LP S AT + PRCGV D + L AR+R +K
Sbjct: 51 WHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSD---------GLSARNR-----QK 96
Query: 122 RFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADI 181
RF G +W K L+YR++ +P L + VR + A ++WS+V+ L F E G ADI
Sbjct: 97 RFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHE-GRADI 155
Query: 182 RLTFFQGDHNDGLGNAFDGPGGALAHAFLP---RRGEAHFDQDERWSLSRRRGRNLFVVL 238
+ F + H D L FDGPGG LAHAF P R G+ HFD DE W++ +G +L V
Sbjct: 156 MIDFARYWHGDDL--PFDGPGGILAHAFFPKTHREGDVHFDYDETWTIGDDQGTDLLQVA 213
Query: 239 AHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGK 298
AHE GH LGL H+ A +ALM+ +Y LS DD VQ LYG+P +V + P
Sbjct: 214 AHEFGHVLGLQHTTAAKALMSAFY-TFRYPLSLSPDDCRGVQHLYGQP-WPTVTSRTPA- 270
Query: 299 LFTDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEV-AADGNVS 357
D+ P+ P C +SFDA++ R +L+ FK W +
Sbjct: 271 -LGPQAGIDTNEIAPLEPDAP-PDACEASFDAVSTIR-GELFFFKAGFVWRLRGGQLQPG 327
Query: 358 EPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRH 417
P W GLP ++AA G +FF+G + W + G KPV G L GL R
Sbjct: 328 YPALASRHWQGLPSPVDAAFEDA-QGHIWFFQGAQYWVYDGEKPVLGPAPLTEL-GLVRF 385
Query: 418 P--DAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDG 475
P A ++ P ++ F+G Y+ +V+ PR DW G+P E+ A DG
Sbjct: 386 PVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADG 445
Query: 476 SIIFFRDDRYWRLDQAKLQA 495
F R YW+ D K++A
Sbjct: 446 YAYFLRGRLYWKFDPVKVKA 465
>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
sapiens]
Length = 562
Score = 207 bits (526), Expect = 2e-53
Identities = 165/542 (30%), Positives = 238/542 (43%), Gaps = 58/542 (10%)
Query: 4 RVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVP---KAPTSTRFS 60
R+ L L AL LLL A+ + Q++ + +L +YGYL P + + +
Sbjct: 2 RLRLRLLALLLLLLAP-PARAPKPSAQDVSLGVD-WLTRYGYLPPPHPAQAQLQSPEKLR 59
Query: 61 DAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRK 120
DAI+ Q + LP +G +D T+ M +PRC + D A +RR+
Sbjct: 60 DAIKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGL--------------VRRR 105
Query: 121 KRFAKQGNKWYKQHLSYRLVNWPE--HLPEPAVRGAVRAAFQLWSNVSALEFWE--APAT 176
+R+A G+ W K+ L++R+ ++P+ L + VR + A W S L F E +P
Sbjct: 106 RRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQG 165
Query: 177 GPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRR----GEAHFDQDERWSLSRR--R 230
DI + F + H D FDG GG LAHAF P G+ HFD +E W+ +
Sbjct: 166 QEPDILIDFARAFHQDSY--PFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGE 223
Query: 231 GRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDA---LLSWDDVLAVQSLYGKPL 287
G +LF V HE GH LGL HS AP ++M P+Y+ D LS DD +Q LYGK
Sbjct: 224 GTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGK-- 281
Query: 288 GGSVAVQLPGKLFTDFETWDSYSPQGRRP--ETQGPKY-----CHSSFDAITVDRQQQLY 340
A Q P D T +P + P T P + C +FDAI + + + +
Sbjct: 282 ----APQTP----YDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEGNFDAI-ANIRGETF 332
Query: 341 IFKGSHFWEVAADGNVSEPRP--LQERWVGLPPN---IEAAAVSLNDGDFYFFKGGRCWR 395
FKG FW + G + PRP L W GLP ++AA DG F G + W
Sbjct: 333 FFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWV 392
Query: 396 FRGPKPVWGLPQLCRAGGLP-RHPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPR 454
F+ + G L G P DA +P + L +G +Y+ + +P YPR
Sbjct: 393 FQDRQLEGGARPLTELGLPPGEEVDAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPR 452
Query: 455 SLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWMGCWHAN 514
L W G P G FF+ YWR + ++ W+ C +
Sbjct: 453 DLSLWEGAPPSPDDVTVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDCPAPS 512
Query: 515 SG 516
SG
Sbjct: 513 SG 514
>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
sapiens]
Length = 469
Score = 201 bits (511), Expect = 1e-51
Identities = 165/494 (33%), Positives = 233/494 (47%), Gaps = 69/494 (13%)
Query: 12 LQLLLWGHLDAQ-PAERGGQELRKE-AEAFLEKYGYLNE---QVPKAPTSTRFSDAIRAF 66
L LL WG + PA QE + + +LEKY L QV K S + ++
Sbjct: 8 LLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQM 67
Query: 67 QWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQ 126
Q L V+G D TL+ M +PRCGV D + +
Sbjct: 68 QEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVL-----------------------TE 104
Query: 127 GN-KWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTF 185
GN +W + HL+YR+ N+ LP V A+ AFQLWSNV+ L F + + G ADI ++F
Sbjct: 105 GNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKV-SEGQADIMISF 163
Query: 186 FQGDHNDGLGNAFDGPGGALAHAFLPR---RGEAHFDQDERWSLSRRRGRNLFVVLAHEI 242
+GDH D + FDGPGG LAHAF P G+AHFD+DERW+ + R NL V AHE+
Sbjct: 164 VRGDHRD--NSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT-NNFREYNLHRVAAHEL 220
Query: 243 GHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTD 302
GH+LGL+HS ALM P Y G D L+ DD+ +Q++YG+
Sbjct: 221 GHSLGLSHSTDIGALMYPSYTFSG-DVQLAQDDIDGIQAIYGR----------------- 262
Query: 303 FETWDSYSPQGRRPETQGPKYCHS--SFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPR 360
+ + P G P+T PK C S +FDAIT R + ++ FK + E
Sbjct: 263 --SQNPVQPIG--PQT--PKACDSKLTFDAITTIRGEVMF-FKDRFYMRTNPFYPEVELN 315
Query: 361 PLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQ-LCRAGGLPR--- 416
+ W LP +EAA + + FFKG + W +G + G P+ + + G PR
Sbjct: 316 FISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVK 375
Query: 417 HPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSL-QDWGGIPEEVSGALPRPDG 475
H DAAL + F +Y+ ++P YP+ + D+ GI +V + DG
Sbjct: 376 HIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMK-DG 434
Query: 476 SIIFFRDDRYWRLD 489
FF R ++ D
Sbjct: 435 FFYFFHGTRQYKFD 448
>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
[Homo sapiens]
Length = 457
Score = 193 bits (491), Expect = 3e-49
Identities = 137/408 (33%), Positives = 198/408 (48%), Gaps = 53/408 (12%)
Query: 12 LQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAP---TSTRFSDAIRAFQW 68
LQ LLW A G E E +L+KYGYL P+ ++ A+ A Q
Sbjct: 23 LQTLLW----ILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQ 78
Query: 69 VSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMR-RKKRFAKQG 127
+ ++G +DR T+ M +PRCGV D R +K R+KR+A G
Sbjct: 79 FYGINMTGKVDRNTIDWMKKPRCGVPDQT--------------RGSSKFHIRRKRYALTG 124
Query: 128 NKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAP------ATGPADI 181
KW +H++Y + N + +P R A+R AF +W NV+ L F E P DI
Sbjct: 125 QKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDI 184
Query: 182 RLTFFQGDHNDGLGNAFDGPGGALAHAFLPR---RGEAHFDQDERWSLS--RRRGRNLFV 236
+ F G H D + FDG GG LAHA+ P G+ HFD DE W+L G +LF+
Sbjct: 185 TIIFASGFHGD--SSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFL 242
Query: 237 VLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDAL-LSWDDVLAVQSLYG-----KPLGGS 290
V HE+GH LGL HS P A+MAP+Y+ + D L DD+ +Q +YG P
Sbjct: 243 VAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRP 302
Query: 291 VAVQLPGKLFTDFETWDSYSPQGRRPETQGPKY-------CHSSFDAITVDRQQQLYIFK 343
+ P + + + P+ RP T P Y C +F+ + + R +++++FK
Sbjct: 303 LPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILR-REMFVFK 361
Query: 344 GSHFWEVAADGNVSEPRPLQER--WVGLPPNIEAAAVSLNDGDFYFFK 389
FW V + V + P+Q W GLPP+I+A + +DG+F FFK
Sbjct: 362 DQWFWRV-RNNRVMDGYPMQITYFWRGLPPSIDAVYEN-SDGNFVFFK 407
>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
Length = 471
Score = 193 bits (490), Expect = 4e-49
Identities = 159/489 (32%), Positives = 223/489 (45%), Gaps = 65/489 (13%)
Query: 8 LLRALQLLLWGHLDAQPAERGGQE--LRKEAEAFLEKY--GYLNEQ----VPKAPTSTRF 59
+L A L W H A P GG E L +E F E+Y Y + + K ++
Sbjct: 5 VLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSM 64
Query: 60 SDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRR 119
++ +R Q L V+G LD TL M +PRCGV D Y + +
Sbjct: 65 TERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTL------------- 111
Query: 120 KKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPA 179
KW K +L+YR+VN+ + V A + AF++WS+V+ L F G A
Sbjct: 112 ---------KWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLH-DGIA 161
Query: 180 DIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRR---GEAHFDQDERWSLSRRRGRNLFV 236
DI ++F +H D FDGP G LAHAF P G+AHFD DE W+ S +G NLF+
Sbjct: 162 DIMISFGIKEHGDFY--PFDGPSGLLAHAFPPGPNYGGDAHFDDDETWT-SSSKGYNLFL 218
Query: 237 VLAHEIGHTLGLTHSPAPRALMAPYYKRLGRD-ALLSWDDVLAVQSLYGKPLGGSVAVQL 295
V AHE GH+LGL HS P ALM P Y G+ +L DDV +QSLYG
Sbjct: 219 VAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYG----------- 267
Query: 296 PGKLFTDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGN 355
PG P + P+T S DAIT R + + IFK FW +
Sbjct: 268 PG----------DEDPNPKHPKTPDKCDPSLSLDAITSLRGETM-IFKDRFFWRLHPQQV 316
Query: 356 VSEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLP 415
+E + W LP I+AA + + F+G + W G + G P+ GLP
Sbjct: 317 DAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLP 376
Query: 416 RHP---DAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSL-QDWGGIPEEVSGALP 471
+ AA+ F + +LF G + + ++ YPR + +D+ GI ++V A+
Sbjct: 377 KEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVD-AVY 435
Query: 472 RPDGSIIFF 480
+G I FF
Sbjct: 436 EKNGYIYFF 444
>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
Length = 403
Score = 191 bits (484), Expect = 2e-48
Identities = 146/429 (34%), Positives = 207/429 (48%), Gaps = 64/429 (14%)
Query: 72 LPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGN-KW 130
L V+G D TL+ M +PRCGV D + +GN +W
Sbjct: 7 LKVTGKPDAETLKVMKQPRCGVPDVAQFVL-----------------------TEGNPRW 43
Query: 131 YKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDH 190
+ HL+YR+ N+ LP V A+ AFQLWSNV+ L F + + G ADI ++F +GDH
Sbjct: 44 EQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKV-SEGQADIMISFVRGDH 102
Query: 191 NDGLGNAFDGPGGALAHAFLPR---RGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLG 247
D + FDGPGG LAHAF P G+AHFD+DERW+ + R NL V AHE+GH+LG
Sbjct: 103 RD--NSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT-NNFREYNLHRVAAHELGHSLG 159
Query: 248 LTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWD 307
L+HS ALM P Y G D L+ DD+ +Q++YG+ + +
Sbjct: 160 LSHSTDIGALMYPSYTFSG-DVQLAQDDIDGIQAIYGR-------------------SQN 199
Query: 308 SYSPQGRRPETQGPKYCHS--SFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQER 365
P G P+T PK C S +FDAIT R + ++ FK + E +
Sbjct: 200 PVQPIG--PQT--PKACDSKLTFDAITTIRGEVMF-FKDRFYMRTNPFYPEVELNFISVF 254
Query: 366 WVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQ-LCRAGGLPR---HPDAA 421
W LP +EAA + + FFKG + W +G + G P+ + + G PR H DAA
Sbjct: 255 WPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAA 314
Query: 422 LFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSL-QDWGGIPEEVSGALPRPDGSIIFF 480
L + F +Y+ ++P YP+ + D+ GI +V + DG FF
Sbjct: 315 LSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMK-DGFFYFF 373
Query: 481 RDDRYWRLD 489
R ++ D
Sbjct: 374 HGTRQYKFD 382
>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
sapiens]
Length = 470
Score = 190 bits (483), Expect = 2e-48
Identities = 151/490 (30%), Positives = 223/490 (45%), Gaps = 69/490 (14%)
Query: 37 EAFLEKYGYLNEQVPKAP-TSTRFS-----DAIRAFQWVSQLPVSGVLDRATLRQMTRPR 90
E +LEK+ L ++ K P T ++S + I+ Q L V+G LD +TL M PR
Sbjct: 34 ERYLEKFYGL--EINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPR 91
Query: 91 CGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPA 150
CGV D + + R G W K +++YR+ N+ +
Sbjct: 92 CGVPDVHHF----------------------REMPGGPVWRKHYITYRINNYTPDMNRED 129
Query: 151 VRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFL 210
V A+R AFQ+WSNV+ L+F + TG ADI + F +G H D +AFDG GG LAHAF
Sbjct: 130 VDYAIRKAFQVWSNVTPLKFSKIN-TGMADILVVFARGAHGDF--HAFDGKGGILAHAFG 186
Query: 211 PRRG---EAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGR 267
P G +AHFD+DE W+ + G NLF+ HEIGH+LGL HS P+A+M P YK +
Sbjct: 187 PGSGIGGDAHFDEDEFWT-THSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDI 245
Query: 268 DAL-LSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYC-- 324
+ LS DD+ +QSLYG P +LP P+ P C
Sbjct: 246 NTFRLSADDIRGIQSLYGDPKENQ---RLP------------------NPDNSEPALCDP 284
Query: 325 HSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGD 384
+ SFDA+T +++ FK FW ++ + + W LP IEAA
Sbjct: 285 NLSFDAVTT-VGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQ 343
Query: 385 FYFFKGGRCWRFRGPKPVWGLPQLCRAGGLP---RHPDAALFFPPLRRLILFKGARYYVL 441
+ FK + W +P P+ + G P + DAA+F P R F +Y+
Sbjct: 344 VFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRY 403
Query: 442 ARGGLQVEPYYPRSL-QDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTSGR 500
++P YP+ + +++ GI ++ + FF+ + D + T +
Sbjct: 404 DERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRIT---K 460
Query: 501 WATELPWMGC 510
W GC
Sbjct: 461 TLKSNSWFGC 470
>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
Length = 477
Score = 188 bits (477), Expect = 1e-47
Identities = 155/498 (31%), Positives = 212/498 (42%), Gaps = 55/498 (11%)
Query: 25 AERGGQELRKEAEAFLEKYGYLNEQVP---KAPTSTRFSDAIRAFQWVSQLPVSGVLDRA 81
A RG + +LE Y L + V + S IR Q L V+G LD
Sbjct: 23 AARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSD 82
Query: 82 TLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVN 141
TL M +PRCGV D + + KW K HL+YR+VN
Sbjct: 83 TLEVMRKPRCGVPDVGHFRTFPGI----------------------PKWRKTHLTYRIVN 120
Query: 142 WPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGP 201
+ LP+ AV AV A ++W V+ L F G ADI ++F +H D FDGP
Sbjct: 121 YTPDLPKDAVDSAVEKALKVWEEVTPLTF-SRLYEGEADIMISFAVREHGDFY--PFDGP 177
Query: 202 GGALAHAFLPR---RGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALM 258
G LAHA+ P G+AHFD DE+W+ G NLF+V AHEIGH+LGL HS ALM
Sbjct: 178 GNVLAHAYAPGPGINGDAHFDDDEQWT-KDTTGTNLFLVAAHEIGHSLGLFHSANTEALM 236
Query: 259 APYYKRLG--RDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRP 316
P Y L LS DD+ +QSLYG P P T + P+ P
Sbjct: 237 YPLYHSLTDLTRFRLSQDDINGIQSLYGPP---------PDSPETPLVPTEPVPPEPGTP 287
Query: 317 ETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAA 376
P SFDA++ R ++ IFK HFW + E + W LP ++AA
Sbjct: 288 ANCDPAL---SFDAVSTLR-GEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAA 343
Query: 377 AVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLP---RHPDAALFFPPLRRLILF 433
+ + FKG + W RG + G P+ G P R DAA+ + F
Sbjct: 344 YEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFF 403
Query: 434 KGARYYVLARGGLQVEPYYPRSL-QDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAK 492
+Y+ +EP +P+ + +D+ GI ++ A+ G FF D
Sbjct: 404 VEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKID-AVFEEFGFFYFFTGSSQLEFDPNA 462
Query: 493 LQATTSGRWATELPWMGC 510
+ T + W+ C
Sbjct: 463 KKVTHT---LKSNSWLNC 477
>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
sapiens]
Length = 483
Score = 188 bits (477), Expect = 1e-47
Identities = 155/491 (31%), Positives = 221/491 (45%), Gaps = 64/491 (13%)
Query: 36 AEAFLEKYGYLNEQVPK-----APTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPR 90
A+A+L+KY Y N++ + A S I+ Q L V+G LD+ T+ + +PR
Sbjct: 41 AQAYLDKY-YTNKEGHQIGEMVARGSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPR 99
Query: 91 CGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPA 150
CGV D +Y R KW K L+YR+ + +
Sbjct: 100 CGVPDVANY----------------------RLFPGEPKWKKNTLTYRISKYTPSMSSVE 137
Query: 151 VRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFL 210
V AV A Q WS+ L F + G ADI ++F GDH D FDGP G LAHAF
Sbjct: 138 VDKAVEMALQAWSSAVPLSFVRINS-GEADIMISFENGDHGDSY--PFDGPRGTLAHAFA 194
Query: 211 PRRG---EAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGR 267
P G + HFD E+W++ G NLF V AHE GH LGL HS P ALM P YK
Sbjct: 195 PGEGLGGDTHFDNAEKWTMGTN-GFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNP 253
Query: 268 DAL-LSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYC-- 324
L DDV +Q+LYG P K+F T P + P C
Sbjct: 254 YGFHLPKDDVKGIQALYG-----------PRKVFLGKPT----LPHAPHHKPSIPDLCDS 298
Query: 325 HSSFDAITVDRQQQLYIFKGSHFWEVAADGNVS-EPRPLQERWVGLPPNIEAAAVSLNDG 383
SSFDA+T+ ++L +FK FW P + + L N++AA G
Sbjct: 299 SSSFDAVTM-LGKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERG 357
Query: 384 DFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHP---DAALFFPPLRRLILFKGARYYV 440
YFFKG W RG + + G P+ G PRH DAA++ ++ + F G YY
Sbjct: 358 TAYFFKGPHYWITRGFQ-MQGPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYS 416
Query: 441 LARGGLQVEPYYPRSL-QDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTSG 499
++E YP++ +++ G+ ++ A+ +G I FF + ++ D K +
Sbjct: 417 YDERKRKMEKDYPKNTEEEFSGVNGQIDAAV-ELNGYIYFFSGPKTYKYDTEKEDVVSVV 475
Query: 500 RWATELPWMGC 510
+ ++ W+GC
Sbjct: 476 KSSS---WIGC 483
>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
Length = 476
Score = 187 bits (474), Expect = 3e-47
Identities = 149/467 (31%), Positives = 209/467 (44%), Gaps = 55/467 (11%)
Query: 36 AEAFLEKYGYLNEQVP--KAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGV 93
A+ +LEKY L + V + S I+ Q L V+G LD TL M +PRCGV
Sbjct: 34 AQQYLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGV 93
Query: 94 TDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRG 153
D ++++ KW K HL+YR+VN+ LP AV
Sbjct: 94 PDVGHFSSFPGM----------------------PKWRKTHLTYRIVNYTPDLPRDAVDS 131
Query: 154 AVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLP-- 211
A+ A ++W V+ L F G ADI ++F +H D +FDGPG +LAHA+ P
Sbjct: 132 AIEKALKVWEEVTPLTF-SRLYEGEADIMISFAVKEHGDFY--SFDGPGHSLAHAYPPGP 188
Query: 212 -RRGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDA- 269
G+ HFD DE+W+ G NLF+V AHE+GH+LGL HS ALM P Y A
Sbjct: 189 GLYGDIHFDDDEKWT-EDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQ 247
Query: 270 -LLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYCHS-- 326
LS DDV +QSLYG P + +P K P G ++ P C
Sbjct: 248 FRLSQDDVNGIQSLYGPPPASTEEPLVPTKSV----------PSG----SEMPAKCDPAL 293
Query: 327 SFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGDFY 386
SFDAI+ R + L+ FK +FW + E + W LP ++AA + +
Sbjct: 294 SFDAISTLRGEYLF-FKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVF 352
Query: 387 FFKGGRCWRFRGPKPVWGLPQLCRAGGLP---RHPDAALFFPPLRRLILFKGARYYVLAR 443
FKG W RG + G P+ G P R DAA+ ++ F +Y+
Sbjct: 353 IFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDE 412
Query: 444 GGLQVEPYYPRSL-QDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLD 489
+E +PR + D+ G+ +V L + G FF + D
Sbjct: 413 NSQSMEQGFPRLIADDFPGVEPKVDAVL-QAFGFFYFFSGSSQFEFD 458
Score = 43.5 bits (101), Expect = 5e-04
Identities = 35/125 (28%), Positives = 56/125 (44%), Gaps = 8/125 (6%)
Query: 371 PNIEAAAVSLNDGDFYFFKGGRCWRFR--GPKPVWGLPQLCRAGGLPRHPDAALFFPPLR 428
P + A+S G++ FFK WR P+P + L LP + DAA
Sbjct: 291 PALSFDAISTLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPS-LPSYLDAAYEVNSRD 349
Query: 429 RLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIP--EEVSGALP-RPDGSIIFFRDDRY 485
+ +FKG ++ + G +V+ YPR + G P ++ A+ + FF D+Y
Sbjct: 350 TVFIFKGNEFWAIR--GNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKY 407
Query: 486 WRLDQ 490
WR D+
Sbjct: 408 WRFDE 412
>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
Length = 467
Score = 172 bits (436), Expect = 7e-43
Identities = 158/518 (30%), Positives = 228/518 (44%), Gaps = 73/518 (14%)
Query: 9 LRALQLLLWGHLDAQPA--ERGGQELRKEAEAFLEKYGYLNE---QVPKAPTSTRFSDAI 63
L+ L LL H+ A ++ K + +LEK+ L Q + + + +
Sbjct: 4 LKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKL 63
Query: 64 RAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRF 123
+ Q L V+G + TL M +PRCGV D+ +
Sbjct: 64 KEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGF-----------------------M 100
Query: 124 AKQGN-KWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIR 182
GN KW + +L+YR+ N+ L E V A++ AF+LWS S L F + G ADI
Sbjct: 101 LTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRI-SQGEADIN 159
Query: 183 LTFFQGDHNDGLGNAFDGPGGALAHAFLPRRG---EAHFDQDERWSLSRRRGRNLFVVLA 239
+ F+Q DH D + FDGP G LAHAF P +G +AHFD +E W+ + NLF+V A
Sbjct: 160 IAFYQRDHGDN--SPFDGPNGILAHAFQPGQGIGGDAHFDAEETWT-NTSANYNLFLVAA 216
Query: 240 HEIGHTLGLTHSPAPRALMAPYYK-RLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGK 298
HE GH+LGL HS P ALM P Y R + L DD+ +Q++YG S +Q G
Sbjct: 217 HEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGL---SSNPIQPTG- 272
Query: 299 LFTDFETWDSYSPQGRRPETQGPKYCHSS--FDAITVDRQQQLYIFKGSHFWEVAADGNV 356
P T PK C S FDAIT R + L+ FK +FW
Sbjct: 273 -----------------PST--PKPCDPSLTFDAITTLRGEILF-FKDRYFWRRHPQLQR 312
Query: 357 SEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLP- 415
E + W LP I+AA + + FKG + W G + G P+ G P
Sbjct: 313 VEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPS 372
Query: 416 --RHPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQD-WGGIPEEVSGALPR 472
+ DAA+F+ + F +++ +EP YP+S+ + GI +V A+ +
Sbjct: 373 SVQAIDAAVFY--RSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVD-AVFQ 429
Query: 473 PDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWMGC 510
+ F RY+ D + T R A W+ C
Sbjct: 430 QEHFFHVFSGPRYYAFDLIAQRVT---RVARGNKWLNC 464
>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
Length = 513
Score = 153 bits (386), Expect = 4e-37
Identities = 146/501 (29%), Positives = 210/501 (41%), Gaps = 68/501 (13%)
Query: 30 QELRKEAEAFLEKYGYLN---EQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQM 86
+E + A+A+L ++ L + ++ + D IR Q L V+G LD TL M
Sbjct: 27 EENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIM 86
Query: 87 TRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHL 146
PRCGV D Y + G W K +L+YR++N+ +
Sbjct: 87 KTPRCGVPDVGQYG----------------------YTLPG--WRKYNLTYRIINYTPDM 122
Query: 147 PEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALA 206
AV A++ ++WS V+ L+F + + G ADI + F H FDGP G L
Sbjct: 123 ARAAVDEAIQEGLEVWSKVTPLKFTKI-SKGIADIMIAFRTRVHGR-CPRYFDGPLGVLG 180
Query: 207 HAFLPRRG---EAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYK 263
HAF P G + HFD+DE W+ G NLF+V AHE GH LGL+HS ALM P Y
Sbjct: 181 HAFPPGPGLGGDTHFDEDENWTKDGA-GFNLFLVAAHEFGHALGLSHSNDQTALMFPNYV 239
Query: 264 RLG-RDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPK 322
L R LS DD+ +QS+YG LP + + E P
Sbjct: 240 SLDPRKYPLSQDDINGIQSIYGG---------LPKE-------------PAKPKEPTIPH 277
Query: 323 YCHS--SFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSL 380
C +FDAIT R++ ++ FKG H W + D E + W LP +++AA +
Sbjct: 278 ACDPDLTFDAITTFRREVMF-FKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYENP 336
Query: 381 NDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLP---RHPDAALFFPPLRRLILFKGAR 437
D FK W RG + P+ G P + DAA+ R+ F G
Sbjct: 337 RD-KILVFKDENFWMIRGYAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIW 395
Query: 438 YYVLARGGLQVEPYYP-RSLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQAT 496
+ ++ +P R ++ + GI V A + G F R + + D T
Sbjct: 396 CWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAF-QYKGFFFFSRGSKQFEYDIKTKNIT 454
Query: 497 TSGRWATELPWMGCWHANSGS 517
R T W C + S
Sbjct: 455 RIMRTNT---WFQCKEPKNSS 472
>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
sapiens]
Length = 569
Score = 138 bits (347), Expect = 1e-32
Identities = 144/514 (28%), Positives = 206/514 (40%), Gaps = 98/514 (19%)
Query: 36 AEAFLEKYGYLN---------EQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQM 86
A+ FL +YG+ E P+ P ++A+R FQ + LP SG LD ATL M
Sbjct: 53 AQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAM 112
Query: 87 TRPRCGVTDTN---SYAAWAERISDLFARHRTKMRRKKRFAKQG------------NKWY 131
RPRCGV D A + AR R R +++G +
Sbjct: 113 NRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFS 172
Query: 132 KQHLSYRLVN--WPEHLPEPAVRGAVRAAFQLWSNVSALEFWE--APATGPADIRLTFFQ 187
K+ LS+RL+ L R V AF++WS V+ L+F E A DI+L F +
Sbjct: 173 KRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGR 232
Query: 188 GDHNDGLGNAFDGPGGALAHAFLPRRGEAHFDQDERWS-LSRRRGRNLFVVLAHEIGHTL 246
G H G AFDG G AHA+ R G+ HFD DE ++ + G +L V HEIGH L
Sbjct: 233 GRHL-GCPRAFDGSGQEFAHAW--RLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVL 289
Query: 247 GLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETW 306
GL H+ ++M P Y L W D A+Q LYG G F+T
Sbjct: 290 GLPHTYRTGSIMQPNYIPQEPAFELDWSDRKAIQKLYGSCEG-------------SFDT- 335
Query: 307 DSYSPQGRRPETQGPKYCHSSFDAITVDRQQ--------QLYIFKGSHFWEVAADGN--- 355
+FD I +R Q Y F+ S +W N
Sbjct: 336 --------------------AFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTR 375
Query: 356 VSEPRPLQERWVGLPPNIEAAAVSL---NDGDFYFFKGGRCWRFRGPKPV--------WG 404
+P + W G+P + A V + + YFF+G + WR+ K
Sbjct: 376 YGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKS 435
Query: 405 LPQLCRAG--GLPRHPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDW--G 460
P+L G G+P D A + + + FK + + +V YP+ + +
Sbjct: 436 YPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPA 495
Query: 461 GIPEE------VSGALPRPDGSIIFFRDDRYWRL 488
IP+ S SI FF+ + YW++
Sbjct: 496 VIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKV 529
>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
Length = 267
Score = 133 bits (335), Expect = 3e-31
Identities = 90/268 (33%), Positives = 130/268 (48%), Gaps = 34/268 (12%)
Query: 24 PAERGGQ-ELR-KEAEAFLEKYGYLNEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRA 81
P E GG EL+ ++A+ +L+++ YL + K S ++ Q LP++G+L+
Sbjct: 21 PQEAGGMSELQWEQAQDYLKRF-YLYDSETKNANSLEAK--LKEMQKFFGLPITGMLNSR 77
Query: 82 TLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVN 141
+ M +PRCGV D Y+ + KW + ++YR+V+
Sbjct: 78 VIEIMQKPRCGVPDVAEYSLFPN----------------------SPKWTSKVVTYRIVS 115
Query: 142 WPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGP 201
+ LP V V A +W L F + G ADI + F +G H D FDGP
Sbjct: 116 YTRDLPHITVDRLVSKALNMWGKEIPLHFRKV-VWGTADIMIGFARGAHGDSY--PFDGP 172
Query: 202 GGALAHAFLPRRG---EAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALM 258
G LAHAF P G +AHFD+DERW+ G N HE+GH+LG+ HS P A+M
Sbjct: 173 GNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVM 232
Query: 259 APYYKRLG-RDALLSWDDVLAVQSLYGK 285
P Y ++ LS DD+ +Q LYGK
Sbjct: 233 YPTYGNGDPQNFKLSQDDIKGIQKLYGK 260
>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
sapiens]
Length = 261
Score = 131 bits (330), Expect = 1e-30
Identities = 73/167 (43%), Positives = 99/167 (59%), Gaps = 8/167 (4%)
Query: 129 KWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQG 188
KW K L+YR++N+P + AV+ ++ A +WSNV+ L F + G ADI+++F+Q
Sbjct: 98 KWNKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQV-QNGDADIKVSFWQW 156
Query: 189 DHNDGLGNAFDGPGGALAHAFLPRRGE---AHFDQDERWSLSRRRGRNLFVVLAHEIGHT 245
H DG FDGPGG L HAFLP G HFD++E WS S G NLF+V HEIGH+
Sbjct: 157 AHEDGW--PFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSAS-DTGYNLFLVATHEIGHS 213
Query: 246 LGLTHSPAPRALMAP-YYKRLGRDALLSWDDVLAVQSLYGKPLGGSV 291
LGL HS ++M P Y+ R LS DD+ +Q LYG+ +
Sbjct: 214 LGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYGEKCSSDI 260
>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
Length = 390
Score = 111 bits (277), Expect = 2e-24
Identities = 73/180 (40%), Positives = 98/180 (54%), Gaps = 14/180 (7%)
Query: 118 RRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPA-VRGAVRAAFQLWSNVSALEFWEAPAT 176
RR+ +W +L+YR++++P +L P R A+ AAF++WS+VS F E
Sbjct: 76 RRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAPE 135
Query: 177 GPADIRLTFFQGDHNDGLGNA----FDGPGGALAHAFLPRRGEAHFDQDERWSL-----S 227
P+D+R+ F+ +H D L +A FDGP G LAHAF P G HFD E W L S
Sbjct: 136 QPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHGGIHFDDSEYWVLGPTRYS 195
Query: 228 RRRG---RNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYG 284
++G +L V AHEIGH LGL HS RALM G A LS D++ + LYG
Sbjct: 196 WKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKA-LSQDELWGLHRLYG 254
>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
Length = 610
Score = 102 bits (255), Expect = 6e-22
Identities = 82/303 (27%), Positives = 132/303 (43%), Gaps = 29/303 (9%)
Query: 216 AHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDD 275
A++D D +W +G +LF+V AHE GH +GL HS P ALMAP Y ++ LS DD
Sbjct: 329 ANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIY-TYTKNFRLSQDD 387
Query: 276 VLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYCHSS--FDAITV 333
+ +Q LYG D + +P P T P+ C FD I
Sbjct: 388 IKGIQELYGAS--------------PDIDLGTGPTPT-LGPVT--PEICKQDIVFDGIAQ 430
Query: 334 DRQQQLYIFKGSHFWE-VAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGR 392
R +++ FK W V P + W LP I+A + + FF G
Sbjct: 431 IR-GEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNE 489
Query: 393 CWRFRGPKPVWGLPQLCRAGGLP---RHPDAALFFPPLRRLILFKGARYYVLARGGLQVE 449
W + G P+ + GLP + DAA + ++ +F G +++ +++
Sbjct: 490 YWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMD 549
Query: 450 PYYPRSLQD-WGGIPEEVSGALP-RPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPW 507
P +P+ + D W IP+ + + + G FF+ Y +L+ L++ G + + W
Sbjct: 550 PGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFG--SIKSDW 607
Query: 508 MGC 510
+GC
Sbjct: 608 LGC 610
Score = 92.4 bits (228), Expect = 9e-19
Identities = 58/169 (34%), Positives = 80/169 (47%), Gaps = 28/169 (16%)
Query: 61 DAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRK 120
D ++ Q LP +G LD+ T+ M +PRCG D +Y
Sbjct: 22 DTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANY--------------------- 60
Query: 121 KRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPAD 180
F + KW K ++YR++ + L V A AFQ+WS+V+ L F G AD
Sbjct: 61 -NFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRF-SRIHDGEAD 118
Query: 181 IRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRR---GEAHFDQDERWSL 226
I + F + +H DG FDG G LAHAF P G++HFD DE W+L
Sbjct: 119 IMINFGRWEHGDGY--PFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTL 165
>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
[Homo sapiens]
Length = 660
Score = 102 bits (255), Expect = 6e-22
Identities = 82/303 (27%), Positives = 132/303 (43%), Gaps = 29/303 (9%)
Query: 216 AHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDD 275
A++D D +W +G +LF+V AHE GH +GL HS P ALMAP Y ++ LS DD
Sbjct: 379 ANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIY-TYTKNFRLSQDD 437
Query: 276 VLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYCHSS--FDAITV 333
+ +Q LYG D + +P P T P+ C FD I
Sbjct: 438 IKGIQELYGAS--------------PDIDLGTGPTPT-LGPVT--PEICKQDIVFDGIAQ 480
Query: 334 DRQQQLYIFKGSHFWE-VAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGR 392
R +++ FK W V P + W LP I+A + + FF G
Sbjct: 481 IR-GEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNE 539
Query: 393 CWRFRGPKPVWGLPQLCRAGGLP---RHPDAALFFPPLRRLILFKGARYYVLARGGLQVE 449
W + G P+ + GLP + DAA + ++ +F G +++ +++
Sbjct: 540 YWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMD 599
Query: 450 PYYPRSLQD-WGGIPEEVSGALP-RPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPW 507
P +P+ + D W IP+ + + + G FF+ Y +L+ L++ G + + W
Sbjct: 600 PGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFG--SIKSDW 657
Query: 508 MGC 510
+GC
Sbjct: 658 LGC 660
Score = 92.4 bits (228), Expect = 9e-19
Identities = 58/169 (34%), Positives = 80/169 (47%), Gaps = 28/169 (16%)
Query: 61 DAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRK 120
D ++ Q LP +G LD+ T+ M +PRCG D +Y
Sbjct: 72 DTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANY--------------------- 110
Query: 121 KRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPAD 180
F + KW K ++YR++ + L V A AFQ+WS+V+ L F G AD
Sbjct: 111 -NFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRF-SRIHDGEAD 168
Query: 181 IRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRR---GEAHFDQDERWSL 226
I + F + +H DG FDG G LAHAF P G++HFD DE W+L
Sbjct: 169 IMINFGRWEHGDGY--PFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTL 215
>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
sapiens]
Length = 183
Score = 102 bits (253), Expect = 1e-21
Identities = 64/166 (38%), Positives = 91/166 (54%), Gaps = 24/166 (14%)
Query: 39 FLEKYGYLNEQVPKAPT--STRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDT 96
+L +YGYL + + + ++A+RAFQ S+LPVSG LD AT +M +PRCG+ D
Sbjct: 31 YLSQYGYLQKPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGLEDP 90
Query: 97 NSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVR 156
+ ++ ++ G +W K+HL++R++N P LP R A+R
Sbjct: 91 FN-------------------QKTLKYLLLG-RWRKKHLTFRILNLPSTLPPHTARAALR 130
Query: 157 AAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPG 202
AFQ WSNV+ L F E A G ADIRL+ F G + N FDGPG
Sbjct: 131 QAFQDWSNVAPLTFQEVQA-GAADIRLS-FHGRQSSYCSNTFDGPG 174
>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
Length = 707
Score = 100 bits (249), Expect = 3e-21
Identities = 69/199 (34%), Positives = 94/199 (47%), Gaps = 29/199 (14%)
Query: 33 RKEAEAFLEKYGYLNEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCG 92
R+ AE +L +YGY + + + A+ Q LP +G LD ATL+ M PRCG
Sbjct: 42 RQLAEEYLYRYGYTRVAEMRGESKS-LGPALLLLQKQLSLPETGELDSATLKAMRTPRCG 100
Query: 93 VTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVR 152
V D + + DL KW+ +++Y + N+ E LP +
Sbjct: 101 VPDLGRFQTFE---GDL-------------------KWHHHNITYWIQNYSEDLPRAVID 138
Query: 153 GAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPR 212
A AF LWS V+ L F + ADI + F +H DG FDG G LAHAF P
Sbjct: 139 DAFARAFALWSAVTPLTFTRV-YSRDADIVIQFGVAEHGDGY--PFDGKDGLLAHAFPPG 195
Query: 213 ---RGEAHFDQDERWSLSR 228
+G+AHFD DE WSL +
Sbjct: 196 PGIQGDAHFDDDELWSLGK 214
Score = 83.6 bits (205), Expect = 4e-16
Identities = 89/319 (27%), Positives = 132/319 (41%), Gaps = 59/319 (18%)
Query: 216 AHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDD 275
++FD D++W +G +LF+V AHE GH LGL HS P ALM P Y R L DD
Sbjct: 377 SNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMY-RFTEGPPLHKDD 435
Query: 276 VLAVQSLYG-----KPLGGSVAVQLPGKLFTDFETW-----------------DSYSPQG 313
V ++ LYG +P + P T T S P G
Sbjct: 436 VNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTG 495
Query: 314 RRPETQGPK------------YCH-SSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPR 360
P T GP C+ + FDAI + QLY+FK +W ++G S P+
Sbjct: 496 --PPTAGPSTATTVPLSPVDDACNVNIFDAI-AEIGNQLYLFKDGKYWRF-SEGRGSRPQ 551
Query: 361 P---LQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRH 417
+ ++W LP +++ +FF G + W + G V G +L + G
Sbjct: 552 GPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGAS-VLGPRRLDKLG---LG 607
Query: 418 PDAALFFPPLR----RLILFKGARYYVLARGGLQVEPYYPRSLQD----WGGIPEEVSGA 469
D A LR +++LF G R L R ++ + PRS + + G+P +
Sbjct: 608 ADVAQVTGALRSGRGKMLLFSGRR---LWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDV 664
Query: 470 LPRPDGSIIFFRDDRYWRL 488
+ F +D YWR+
Sbjct: 665 FQYRE-KAYFCQDRFYWRV 682
>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
Length = 358
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/86 (43%), Positives = 45/86 (52%), Gaps = 7/86 (8%)
Query: 141 NWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTF-FQGDHNDGLGNAFD 199
N+ +LP+ V A AF+LWSN SAL F DI L+F F D +D + F
Sbjct: 188 NYMPNLPQEDVDRATGKAFELWSNASALTF-TRDFESEGDIILSFVFLADLHD--NSPFY 244
Query: 200 GPGGALAHAFLPR---RGEAHFDQDE 222
G G LAHAF P G+ HFD DE
Sbjct: 245 GHDGCLAHAFPPGPGIGGDVHFDNDE 270
>gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]
Length = 198
Score = 51.6 bits (122), Expect = 2e-06
Identities = 37/86 (43%), Positives = 45/86 (52%), Gaps = 7/86 (8%)
Query: 141 NWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTF-FQGDHNDGLGNAFD 199
N+ +LP+ V A AF+LWSN SAL F DI L+F F D +D + F
Sbjct: 28 NYMPNLPQEDVDRATGKAFELWSNASALTF-TRDFESEGDIILSFVFLADLHD--NSPFY 84
Query: 200 GPGGALAHAFLPR---RGEAHFDQDE 222
G G LAHAF P G+ HFD DE
Sbjct: 85 GHDGCLAHAFPPGPGIGGDVHFDNDE 110
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.457
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,126,085
Number of Sequences: 37866
Number of extensions: 1174134
Number of successful extensions: 2455
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2110
Number of HSP's gapped (non-prelim): 94
length of query: 520
length of database: 18,247,518
effective HSP length: 107
effective length of query: 413
effective length of database: 14,195,856
effective search space: 5862888528
effective search space used: 5862888528
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.