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Search of human proteins with 109255239
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109255239 centrosomal protein 63 isoform b [Homo sapiens]
(541 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109255239 centrosomal protein 63 isoform b [Homo sapiens] 1040 0.0
gi|22095367 centrosomal protein 63 isoform a [Homo sapiens] 940 0.0
gi|109255226 centrosomal protein 63 isoform c [Homo sapiens] 928 0.0
gi|109255236 centrosomal protein 63 isoform d [Homo sapiens] 828 0.0
gi|116812628 coiled-coil domain containing 67 [Homo sapiens] 210 3e-54
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 102 1e-21
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 100 6e-21
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 97 3e-20
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 97 3e-20
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 94 3e-19
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 94 4e-19
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 94 4e-19
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 94 4e-19
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 93 5e-19
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 92 1e-18
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 92 2e-18
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 92 2e-18
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 91 2e-18
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 91 2e-18
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 90 6e-18
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 90 6e-18
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 89 1e-17
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 89 1e-17
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 89 1e-17
gi|31982906 cingulin-like 1 [Homo sapiens] 89 1e-17
gi|21735548 centrosomal protein 2 [Homo sapiens] 88 2e-17
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 88 2e-17
gi|42794779 myosin 18A isoform b [Homo sapiens] 87 3e-17
gi|28416946 myosin 18A isoform a [Homo sapiens] 86 7e-17
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 86 1e-16
>gi|109255239 centrosomal protein 63 isoform b [Homo sapiens]
Length = 541
Score = 1040 bits (2688), Expect = 0.0
Identities = 541/541 (100%), Positives = 541/541 (100%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV
Sbjct: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
Query: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL
Sbjct: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
Query: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV
Sbjct: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
Query: 481 MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL 540
MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL
Sbjct: 481 MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL 540
Query: 541 K 541
K
Sbjct: 541 K 541
>gi|22095367 centrosomal protein 63 isoform a [Homo sapiens]
Length = 703
Score = 940 bits (2429), Expect = 0.0
Identities = 497/536 (92%), Positives = 508/536 (94%), Gaps = 10/536 (1%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV
Sbjct: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
Query: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL
Sbjct: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
Query: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV
Sbjct: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
Query: 481 MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 536
MKLELGLHE I+ L+E + + L +L + ++L+++ T Q
Sbjct: 481 MKLELGLHEAK-------EISLADLQENYIEA---LNKLVSENQQLQKDLMNTKSQ 526
Score = 143 bits (360), Expect = 5e-34
Identities = 145/574 (25%), Positives = 256/574 (44%), Gaps = 62/574 (10%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
+E++ L +I+ K +WE + + + E + K+L Q ++ ++ Q++
Sbjct: 137 SEIERLTAKIEEF-RQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL 195
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNT-------KNHRED 135
E E Q +L++ ++ +C + E+L + + + G + + E
Sbjct: 196 ESVELSSQSEIQHLSSKLERANDTICANELEIERLTMR-VNDLVGTSMTVLQEQQQKEEK 254
Query: 136 RSEIERLTAKIEEFRQ--KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
E E+L ++E ++ K+ ++ LI++ ++ + Q K A ++ + R++
Sbjct: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREE 314
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
L + +SQ + L S L + N T + +L +T L S T Q Q+ E
Sbjct: 315 SLAEKKYTSQGQ-GDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELME 373
Query: 254 KLRESEKLLEALQEEKRELKAA----LQSQENLIHEARIQKEKLQEKVKATNTQHAVEAI 309
K E +++ E K E+K LQ +++ K ++ + + + A
Sbjct: 374 KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAS 433
Query: 310 RPREESLAEKKYTSQGQGDLDSVLS-----------QLNFTHTSEDLLQAEVTCLEG--- 355
S EK+ ++ Q D + +L H SE +++ E+ E
Sbjct: 434 TKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHEAKEI 493
Query: 356 SLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEI-----KKLKEQILQGEQSYSSAL 410
SL + + +L+ + ++L++ + N + + EI KK ++I + S ++
Sbjct: 494 SLADLQENYIEALNKLVSENQQLQK-DLMNTKSQLEISTQMCKKQNDRIFKPTHSRTTEF 552
Query: 411 EGMKMEISH-------LTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEIL 463
+ + + +H + E ++ D+ S +G +SD + + + +
Sbjct: 553 KNTEFKPTHGQHRHDGIKTEHYKTDLH--SPRGQASDSINPMSRVLSPLSPQ-ISPCSST 609
Query: 464 DQLESLKLENRH----------------LSEMVMKLELGLHECSLPVSPLGSIATRFLEE 507
L S L H +SE + E + CSLPVSPLGSIATRFLEE
Sbjct: 610 RSLTSYSLCKTHSLPSALDTNEANFSDTMSESMNDQEEFISSCSLPVSPLGSIATRFLEE 669
Query: 508 EELRSHHILERLDAHIEELKRESEKTVRQFTALK 541
EELRSHHILERLDAHIEELKRESEKTVRQFTALK
Sbjct: 670 EELRSHHILERLDAHIEELKRESEKTVRQFTALK 703
>gi|109255226 centrosomal protein 63 isoform c [Homo sapiens]
Length = 495
Score = 928 bits (2398), Expect = 0.0
Identities = 495/541 (91%), Positives = 495/541 (91%), Gaps = 46/541 (8%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
NTQHAVEAI SLESV
Sbjct: 301 NTQHAVEAI----------------------------------------------SLESV 314
Query: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL
Sbjct: 315 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 374
Query: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV
Sbjct: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
Query: 481 MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL 540
MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL
Sbjct: 435 MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL 494
Query: 541 K 541
K
Sbjct: 495 K 495
>gi|109255236 centrosomal protein 63 isoform d [Homo sapiens]
Length = 475
Score = 828 bits (2138), Expect = 0.0
Identities = 443/489 (90%), Positives = 443/489 (90%), Gaps = 46/489 (9%)
Query: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE
Sbjct: 1 MEALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQE 60
Query: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK
Sbjct: 61 LKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK 120
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ
Sbjct: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQ 180
Query: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT
Sbjct: 181 SEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGT 240
Query: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT
Sbjct: 241 SMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKAT 300
Query: 301 NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
NTQHAVEAI SLESV
Sbjct: 301 NTQHAVEAI----------------------------------------------SLESV 314
Query: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL
Sbjct: 315 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 374
Query: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV
Sbjct: 375 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 434
Query: 481 MKLELGLHE 489
MKLELGLHE
Sbjct: 435 MKLELGLHE 443
>gi|116812628 coiled-coil domain containing 67 [Homo sapiens]
Length = 604
Score = 210 bits (534), Expect = 3e-54
Identities = 160/538 (29%), Positives = 273/538 (50%), Gaps = 78/538 (14%)
Query: 8 IQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQ 67
++N+ H + CEAELQELM+QIDIMV++KK +WE + ALET L +R+QEL + ++
Sbjct: 1 MENQAHNTMGTSPCEAELQELMEQIDIMVSNKKMDWERKMRALETRLDLRDQELANAQTC 60
Query: 68 LDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRG 127
LD +EVG+L Q+++ EK MT Y+ +L+ L + L ++EKL+ QM++ +
Sbjct: 61 LDQKGQEVGLLRQKLDSLEKCNLAMTQNYEGQLQSLKAQFSKLTNNFEKLRLHQMKQNKV 120
Query: 128 NTKN----HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAE---- 179
K E E+ L K+EEFR KS +W+KQ ++YQ + SL+AQ+K L+E
Sbjct: 121 PRKELPHLKEEIPFELSNLNQKLEEFRAKSREWDKQEILYQTHLISLDAQQKLLSEKCNQ 180
Query: 180 ---QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVND 236
Q++ Q QL +KQ LE S SEI L + + +E IE+L VN+
Sbjct: 181 FQKQAQSYQTQLNGKKQCLE----DSSSEIPRLICDPDPNCEINERDEFIIEKLKSAVNE 236
Query: 237 LVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKL-QE 295
+ + + E Q+ ++L+ ++ +A++ E+K+ LQS+++L+ +++ +L +E
Sbjct: 237 IALSRNKLQDENQKLLQELKMYQRQCQAMEAGLSEVKSELQSRDDLLRIIEMERLQLHRE 296
Query: 296 KVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEG 355
+K Q+A Q T LE
Sbjct: 297 LLKIGECQNA-----------------------------------------QGNKTRLES 315
Query: 356 S-LESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMK 414
S L S+ +E K +EL + ++ E+ K++ Q+ Q E+ ++S E M+
Sbjct: 316 SYLPSI--------KEPERKIKELFSVMQDQPNHEKELNKIRSQLQQVEEYHNSEQERMR 367
Query: 415 MEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENR 474
EIS LT+ELHQ++ITIA+ ++ +EK+L+ E++ E + K + ++++ EN
Sbjct: 368 NEISDLTEELHQKEITIATVTKKAALLEKQLKMELEIKEKMLAKQKVSDMKYKAVRTENT 427
Query: 475 HLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEK 532
HL M+ L+ G + ++ F E+ R H + +L E L+ + K
Sbjct: 428 HLKGMMGDLDPGEY-----------MSMDFTNREQSR-HTSINKLQYENERLRNDLAK 473
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 102 bits (253), Expect = 1e-21
Identities = 93/385 (24%), Positives = 188/385 (48%), Gaps = 37/385 (9%)
Query: 39 KKSEWEGRTHALETCL-----KIREQELKSLRSQLDVTHKEVGMLHQQV---EEHEKIK- 89
K EWE + E + KIREQE K R + + KE M Q+ E+ EK++
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 90 -QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEE 148
+EM E ++++++L E++ ++ E+ +K+Q E + +E +++ R KI E
Sbjct: 368 LEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 427
Query: 149 FRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL-ESVELSSQSEIQ 207
+K + EK+ +Q + Q K E+ Q ++ +++K+ E E+ Q E
Sbjct: 428 QEEKIREQEKK---MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKM 484
Query: 208 HLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQ--QKEEKLRESEKLLEAL 265
H K+ + + + E ++ ++ + QE++ ++EEK+RE E+ +
Sbjct: 485 HEQEKIRKQEEKVWRQEEKMHDQEEKIRE---------QEEKMWRQEEKIREQEEKIREQ 535
Query: 266 QEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQG 325
+E+ RE + +Q QE + E Q+EK+QE+ K + E IR +EE + E+K +
Sbjct: 536 EEKIREQEEMMQEQEEKMGE---QEEKMQEQEKMRRQE---EKIREQEEKIREQKEKIRE 589
Query: 326 QGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHN 385
Q + + Q E+++Q + E E C+Q +++ E+ E+++R E
Sbjct: 590 QE--EKIWEQEEKIREQEEMMQEQE---EKMWEQEEKMCEQ-EEKMQEQEEKMRRQEEKM 643
Query: 386 NEYKAEIKKLKEQILQGEQSYSSAL 410
E + +++ +E++ + ++ +A+
Sbjct: 644 WEQEVRLRQQEEKMQEHQEHLEAAI 668
Score = 69.7 bits (169), Expect = 6e-12
Identities = 75/306 (24%), Positives = 143/306 (46%), Gaps = 34/306 (11%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
E + ++ + H + E + QE K I K+ E E + E KIREQE
Sbjct: 376 EEKIRELEEKMHEQEKIREQEEKRQEEEK---IREQEKRQEQEAKMWRQEE--KIREQEE 430
Query: 62 KSLRSQLDVTHKEVGMLHQQ--VEEHEKIKQEMTMEYKQELKKLHEELCILK---RSYEK 116
K +R Q ++ +H+Q + E EK +++ M ++E + EE+ K EK
Sbjct: 431 K-IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK 489
Query: 117 LQKKQMREFRGNTKNHRED---RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQ 173
++K++ + +R K H ++ R + E++ + E+ R++ +Q ++Q ++ Q
Sbjct: 490 IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQ 549
Query: 174 RKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMR 233
+ + EQ E +Q Q R+Q+ + E + +I+ K+ + I E +I
Sbjct: 550 EEKMGEQEEKMQEQEKMRRQEEKIRE--QEEKIREQKEKIREQEEKIWEQEEKIRE---- 603
Query: 234 VNDLVGTSMTVLQEQQQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQ 289
++QEQ++K EEK+ E E+ ++ +E+ R + + QE + R Q
Sbjct: 604 -------QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL---RQQ 653
Query: 290 KEKLQE 295
+EK+QE
Sbjct: 654 EEKMQE 659
Score = 65.9 bits (159), Expect = 9e-11
Identities = 109/531 (20%), Positives = 221/531 (41%), Gaps = 81/531 (15%)
Query: 45 GRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE-------HEKIKQEMTMEYK 97
G H+ E K Q ++LR +L+ + +L Q E + +++ E +
Sbjct: 102 GGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR 161
Query: 98 QELKKLHE------ELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQ 151
+ +LH+ EL + +KK R TK E+ R T EE ++
Sbjct: 162 DLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 221
Query: 152 KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSS 211
K+ +++ + + + S ++ K L + E +A+L+ +Q+L++ E+Q +S+
Sbjct: 222 KNAKLQEKLQLVESEKSEIQLNVKELKRKLE--RAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 212 KLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRE 271
KL+ ++E L R+N QQ+EEK+ E+ ++ +E+ +E
Sbjct: 280 KLQA--------QVEENELWNRLN-------------QQQEEKMWRQEEKIQEWEEKIQE 318
Query: 272 LKAALQSQENLIHE----ARIQKEKLQEKVKATNTQHAV-----EAIRPREESLAEKKYT 322
+ ++ QE I E R Q+E + EK + Q + E +R EE + EK+
Sbjct: 319 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEK 378
Query: 323 SQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLE-GSLESVSATCKQLSQELMEKYEELKRM 381
+ +L+ + + E+ Q E E + A + +++ E+ E+++
Sbjct: 379 IR---ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 435
Query: 382 E---------AHNNEYKAEIKKLKEQ---ILQGEQSYSSALEGMKMEISHLTQELHQRDI 429
E H E E +K +EQ Q E+ + E H +++ +++
Sbjct: 436 EKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEE 495
Query: 430 TIASTKGSSSDMEKRLRAE---MQKAEDKAVEHKE-ILDQLESLKLENRHLSEMVMKLEL 485
+ + D E+++R + M + E+K E +E I +Q E ++ + + E K
Sbjct: 496 KVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEK--- 552
Query: 486 GLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 536
+G + E+E++R E++ E+++ + EK Q
Sbjct: 553 -----------MGEQEEKMQEQEKMRRQE--EKIREQEEKIREQKEKIREQ 590
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 99.8 bits (247), Expect = 6e-21
Identities = 138/565 (24%), Positives = 251/565 (44%), Gaps = 65/565 (11%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLH---- 79
++ E Q+ ++ + E E L K + ELK++ L + + E+ L
Sbjct: 1662 QISERKTQLTLIKQEIEKEEENLQVVLRQMSK-HKTELKNILDMLQLENHELQGLKLQHD 1720
Query: 80 QQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYE---KLQKKQMREFRGNTKNHREDR 136
Q+V E EK Q +E K EL+ L + K E +L ++ RE T R +
Sbjct: 1721 QRVSELEKT-QVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMTAESRALQ 1779
Query: 137 SEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK--QK 194
S +E L+ + E+ ++K WEK+ ++ +++ E K EQS + + +L RK Q+
Sbjct: 1780 SCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKM--EQSNLEKLELNVRKLQQE 1837
Query: 195 LESV---ELSSQSEIQHLSSKLERANDTICANELEI----ERLTMRVNDLVGTSM---TV 244
L+ + +LS ++I + +L+ + + + + E+ + L + DL+ T+ +
Sbjct: 1838 LDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVL 1897
Query: 245 LQEQQ----------------QKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARI 288
L EQ QKEE+ ++ + L+ LQ E E K L QE + R+
Sbjct: 1898 LSEQTRLQKDISEWANRFEDCQKEEETKQQQ--LQVLQNEIEENKLKLVQQEMMFQ--RL 1953
Query: 289 QKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQA 348
QKE+ E+ K ++ ++ ++ EK+ T Q + LD VLS++ LQ
Sbjct: 1954 QKERESEESKLETSKVTLK----EQQHQLEKELTDQ-KSKLDQVLSKVLAAEERVRTLQE 2008
Query: 349 EVTCLEGSLESVSATCKQLS---QELMEKYEELKRMEAHNNEYKAEIKKLKEQIL----Q 401
E E +++S T +QLS Q+L+EK EL ++ + +A+ L+ Q L +
Sbjct: 2009 EERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKK 2068
Query: 402 GEQSYSSALEGMKMEISHLTQELHQR-------DITIASTKGSSSDMEKRLRAEMQKAED 454
E+ +S E +K++ S L + L ++ +A+ + + D +R R M++
Sbjct: 2069 AEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQ 2128
Query: 455 KAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHH 514
E+ E+ Q+ + K R E+ + E + +FL E
Sbjct: 2129 MQYEYTELKKQMANQKDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEA 2188
Query: 515 ILER---LDAHIEELKRESEKTVRQ 536
ILER L+ +E LK T+ +
Sbjct: 2189 ILERNENLEGELESLKENLPFTMNE 2213
Score = 79.0 bits (193), Expect = 1e-14
Identities = 106/487 (21%), Positives = 210/487 (43%), Gaps = 50/487 (10%)
Query: 75 VGMLHQQVEEHEKIKQEMTM--EYKQELK-KLHEELCILKRSYEKLQKKQMREFRGNTKN 131
+G+LH V EH ++ E++ + Q LK K EE + R+ ++ +K+M E N +
Sbjct: 1308 MGVLHCNVPEHHNLENEVSRLEDIMQHLKSKKREERWM--RASKRQSEKEMEELHHNIDD 1365
Query: 132 HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR 191
+++ +E ++EE + ++Q+ V SL + + E+S +V+
Sbjct: 1366 LLQEKKSLE---CEVEELHRTVQKRQQQKDFIDGNVESLMTELE--IEKSLKHHEDIVDE 1420
Query: 192 KQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
+ +E L +SE++ L A + + E+ V ++LQ +
Sbjct: 1421 IECIEKTLLKRRSELREADRLLAEAESELSCTK---EKTKNAVEKFTDAKRSLLQTESDA 1477
Query: 252 EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK--ATNTQHAVEAI 309
EE R +++ L + ++L+ +LQ+ + + +I++E++ +++ + +
Sbjct: 1478 EELERRAQETAVNLVKADQQLR-SLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCL 1536
Query: 310 RPREESLAEKKYTSQGQGDLDSVLSQLNFTH------TSEDLLQ---AEVTCLEGSLESV 360
++E L E+ Q D +++ N H SE LLQ AE+ L+ + S
Sbjct: 1537 SKKKEKLTEELQKLQ----KDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQ 1592
Query: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGE----------QSYSSAL 410
L ++L K EEL ++ + KA+ L+E + GE + S L
Sbjct: 1593 QQEMAVLDRQLGHKKEELHLLQGSMVQAKAD---LQEALRLGETEVTEKCNHIREVKSLL 1649
Query: 411 EGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD------ 464
E + + L ++ +R + K E+ L+ +++ E K ILD
Sbjct: 1650 EELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLEN 1709
Query: 465 -QLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHI 523
+L+ LKL++ + K ++ + E L + L I+ + E E + +LER I
Sbjct: 1710 HELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQK-QLLERDKREI 1768
Query: 524 EELKRES 530
E + ES
Sbjct: 1769 ERMTAES 1775
Score = 77.0 bits (188), Expect = 4e-14
Identities = 117/545 (21%), Positives = 236/545 (43%), Gaps = 75/545 (13%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E E++EL ID ++ KKS E L ++ R+Q+ + ++ E+ + +
Sbjct: 1353 EKEMEELHHNIDDLLQEKKS-LECEVEELHRTVQKRQQQKDFIDGNVESLMTEL-EIEKS 1410
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREF---RGNTKNHREDRSE 138
++ HE I E+ K LK+ E R ++L + E + TKN E ++
Sbjct: 1411 LKHHEDIVDEIECIEKTLLKRRSE-----LREADRLLAEAESELSCTKEKTKNAVEKFTD 1465
Query: 139 IER----LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQK 194
+R + EE +++ + + QQ+ SL+A K L EQ +I Q +++ ++
Sbjct: 1466 AKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDL-EQHKIKQEEIL---KE 1521
Query: 195 LESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEK 254
+ + + S+ Q LS K E+ + + + +IE + + +
Sbjct: 1522 INKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAE--------------RNEDHHLQV 1567
Query: 255 LRESEKLLEALQEEKRELKAALQSQE-----------------NLIHEARIQ-KEKLQEK 296
L+ESE LL+A + E +LK+ + SQ+ +L+ + +Q K LQE
Sbjct: 1568 LKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEA 1627
Query: 297 VKATNTQHAVEAIRPRE-ESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEG 355
++ T+ + RE +SL E+ +G+ ++ Q++ T L++ E+ E
Sbjct: 1628 LRLGETEVTEKCNHIREVKSLLEELSFQKGELNV-----QISERKTQLTLIKQEI---EK 1679
Query: 356 SLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKM 415
E++ +Q+S+ E L ++ N+E + + +++ + E++ + LE K+
Sbjct: 1680 EEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLE-EKL 1738
Query: 416 EISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRH 475
E+ +L Q Q+ KG ++ L + ++ E E + + +E L E
Sbjct: 1739 ELENLQQISQQQ-------KGEIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKED 1791
Query: 476 LSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVR 535
L E E L + ++ EE LE+L+ ++ +L++E ++ R
Sbjct: 1792 LQEKCDIWEKKLAQTKRVLAA--------AEENSKMEQSNLEKLELNVRKLQQELDQLNR 1843
Query: 536 QFTAL 540
+L
Sbjct: 1844 DKLSL 1848
Score = 72.0 bits (175), Expect = 1e-12
Identities = 114/508 (22%), Positives = 207/508 (40%), Gaps = 87/508 (17%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
L+T L+ +E+++ + +++L H E+ QQ+ + +E K+L EE
Sbjct: 435 LDTQLEDKEKKISAAQTRLSELHDEIEKAEQQI-----------LRATEEFKQL-EEAIQ 482
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSS 169
LK+ E + ++ G + + R E L ++E+ +Q+ +K+ Q + S
Sbjct: 483 LKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDS 542
Query: 170 LE----------AQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERAND- 218
L+ AQ+ +Q +I+ Q + +L+ + E + + E+ +
Sbjct: 543 LDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEG 602
Query: 219 TICANEL---EIERLTMRVNDLVGTSMTVLQEQQQKEEKLR-ESEKLLEAL---QEEKRE 271
I ANE ++E + + + +GT + Q + KLR E E LL+ L ++E+ +
Sbjct: 603 QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ 662
Query: 272 LKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDS 331
L+ EN+ +++L E A QH V A Q QGDL +
Sbjct: 663 LEIVAMDAENM-------RKELAELESALQEQHEVNA------------SLQQTQGDLSA 703
Query: 332 VLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAE 391
++L +L AE L+ LE V+ QL Q ++ E +R N KA+
Sbjct: 704 YEAEL---EARLNLRDAEANQLKEELEKVT-RLTQLEQSALQAELEKERQALKNALGKAQ 759
Query: 392 IKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK 451
+ KEQ E S ELH + + K + +
Sbjct: 760 FSEEKEQ----ENS-----------------ELHAKLKHLQDDNNLLKQQLKDFQNHLNH 798
Query: 452 AEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSL--PVSPLG-SIATRFLEEE 508
D V +E+ +++ L+ KL+LG E ++ P LG S+A +
Sbjct: 799 VVDGLVRPEEVAARVDELR----------RKLKLGTGEMNIHSPSDVLGKSLADLQKQFS 848
Query: 509 ELRSHHILERLDAHIEELKRESEKTVRQ 536
E+ + ER +A + E K + E ++Q
Sbjct: 849 EILARSKWERDEAQVRERKLQEEMALQQ 876
Score = 68.6 bits (166), Expect = 1e-11
Identities = 77/399 (19%), Positives = 175/399 (43%), Gaps = 49/399 (12%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLD----VTHK 73
L E+ LQE +++ + + + LE L +R+ E L+ +L+ +T
Sbjct: 677 LAELESALQE-QHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQL 735
Query: 74 EVGMLHQQVEEHEKI------KQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRG 127
E L ++E+ + K + + E +QE +LH +L L+ L K+Q+++F+
Sbjct: 736 EQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDD-NNLLKQQLKDFQN 794
Query: 128 NTKNHREDRSEIERLTAKIEEFRQK------SLDWEKQRLIYQQQVSSLEAQRKALAEQS 181
+ + + E + A+++E R+K ++ + + ++ L+ Q + +S
Sbjct: 795 HLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARS 854
Query: 182 EIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTS 241
+ + + R++KL+ Q ++ + +A C LE R+N
Sbjct: 855 KWERDEAQVRERKLQEEMALQQEKLATGQEEFRQA----CERALEA-----RMNF----- 900
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
+++Q E ++++ E + LQE + ++ + + EA +KE++ +++
Sbjct: 901 -----DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELE 955
Query: 302 TQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLN-FTHTSEDLLQAEVTCLEGSLESV 360
+ +E + +E+ LD L +L TS+ L AE+T + L+S+
Sbjct: 956 KKKKLEDAKSQEQVFG-----------LDKELKKLKKAVATSDKLATAELTIAKDQLKSL 1004
Query: 361 SATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI 399
T +++QE E+ +E +R + ++ + + +I
Sbjct: 1005 HGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEI 1043
Score = 65.9 bits (159), Expect = 9e-11
Identities = 108/542 (19%), Positives = 226/542 (41%), Gaps = 68/542 (12%)
Query: 22 EAELQELMKQIDIMVAH--KKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLH 79
+ E+++L ID + + K S + + E L I ++ + L S+LD +
Sbjct: 530 QKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKET 589
Query: 80 QQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNH-REDRSE 138
+++++ E+ E + + LKK E + ++E+ G K + ++E
Sbjct: 590 EEIKDLEEQLTEGQIAANEALKKDLEGVI-----------SGLQEYLGTIKGQATQAQNE 638
Query: 139 IERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
+L + E Q+ + E++R + E RK LAE +Q Q ++ +
Sbjct: 639 CRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQ-----HEVNAS 693
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRES 258
+Q ++ ++LE + A +++ +V L + LQ + +KE + ++
Sbjct: 694 LQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKN 753
Query: 259 EKLLEALQEEKRELKAALQSQ-ENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLA 317
EEK + + L ++ ++L + + K++L++ N H V+ + EE A
Sbjct: 754 ALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLN--HVVDGLVRPEEVAA 811
Query: 318 E----KKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELME 373
++ G G+++ H+ D+L + L+ + A K E
Sbjct: 812 RVDELRRKLKLGTGEMN--------IHSPSDVLGKSLADLQKQFSEILARSKWERDEAQV 863
Query: 374 KYEELKRMEAHNNEYKA----EIKKLKEQILQG-----EQSYSSALEGMKMEISHLTQEL 424
+ +L+ A E A E ++ E+ L+ ++ + + ++ M+ EI +L + L
Sbjct: 864 RERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENL 923
Query: 425 HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESL----KLENRHLSEMV 480
S +++ ++Q+A++ E + IL QL L KLE+ E V
Sbjct: 924 K-----------SMEEIQGLTDLQLQEADE---EKERILAQLRELEKKKKLEDAKSQEQV 969
Query: 481 MKLELGLHECSLPVSPLGSIATRFL--EEEELRSHH-----ILERLDAHIEELKRESEKT 533
L+ L + V+ +AT L +++L+S H I + ++E +R S K
Sbjct: 970 FGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKA 1029
Query: 534 VR 535
+
Sbjct: 1030 AQ 1031
Score = 65.5 bits (158), Expect = 1e-10
Identities = 98/487 (20%), Positives = 211/487 (43%), Gaps = 46/487 (9%)
Query: 56 IREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYE 115
I +ELKS +++ K L++ ++E ++++ E K +L +E +LK+
Sbjct: 284 IETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNE---LLKQKTI 340
Query: 116 KLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQ--VSSLEAQ 173
+L + +++ E ++ AK E ++ + + + +
Sbjct: 341 ELTRACQKQYE------LEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYK 394
Query: 174 RKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMR 233
R A +S II + + +K+E E Q H++ + DT ++E +
Sbjct: 395 RNMFATESYIIDSAQAVQIKKMEPDE---QLRNDHMNLRGHTPLDT------QLEDKEKK 445
Query: 234 VNDLVGTSMTVLQEQQQKEEK--LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKE 291
++ T ++ L ++ +K E+ LR +E+ + EE +LK ++ ++L+++ +
Sbjct: 446 IS-AAQTRLSELHDEIEKAEQQILRATEEFKQL--EEAIQLKKISEAGKDLLYKQLSGRL 502
Query: 292 KLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVT 351
+L K++ ++ + ++E ++K DL + L+ ++A+ +
Sbjct: 503 QLVNKLRQEALDLELQMEKQKQEIAGKQKEIK----DLQIAIDSLDSKDPKHSHMKAQKS 558
Query: 352 CLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALE 411
E L+ ++ +QL L +E+ A E EIK L+EQ+ +G+ +A E
Sbjct: 559 GKEQQLDIMNKQYQQLESRL----DEILSRIAKETE---EIKDLEEQLTEGQ---IAANE 608
Query: 412 GMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKL 471
+K ++ + L + TI + + ++LR E + + E ++ DQLE + +
Sbjct: 609 ALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAM 668
Query: 472 ENRHLSEMVMKLELGL---HECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKR 528
+ ++ + + +LE L HE + + + + E E R L DA +LK
Sbjct: 669 DAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEAR----LNLRDAEANQLKE 724
Query: 529 ESEKTVR 535
E EK R
Sbjct: 725 ELEKVTR 731
Score = 63.5 bits (153), Expect = 5e-10
Identities = 82/354 (23%), Positives = 153/354 (43%), Gaps = 33/354 (9%)
Query: 39 KKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQ 98
+ E R L LK+ E+ ++ S DV K + L +Q E + E +
Sbjct: 805 RPEEVAARVDELRRKLKLGTGEM-NIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQV 863
Query: 99 ELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLT--AKIEEFRQKSLDW 156
+KL EE+ + + EKL Q EFR + E R ++ A+I++ + + +
Sbjct: 864 RERKLQEEMALQQ---EKLATGQ-EEFRQACERALEARMNFDKRQHEARIQQM-ENEIHY 918
Query: 157 EKQRLIYQQQVSSL-EAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLER 215
++ L +++ L + Q + E+ E I AQL ++K + + SQ ++ L +L++
Sbjct: 919 LQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKK 978
Query: 216 ANDTICANE-LEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKA 274
+ ++ L LT+ + L TV++ Q++ E+L+E+E+ + R+L
Sbjct: 979 LKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTR 1038
Query: 275 ALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLS 334
A EA I E LQ ++ Q + E + T G G VL
Sbjct: 1039 A---------EAEI--ELLQNLLRQKGEQFRL-----------EMEKTGVGTGANSQVLE 1076
Query: 335 QLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEY 388
T E + E+ L+ L+ + K + ++E+ EL+R ++ N+Y
Sbjct: 1077 IEKLNETME-RQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDY 1129
Score = 48.5 bits (114), Expect = 2e-05
Identities = 107/544 (19%), Positives = 216/544 (39%), Gaps = 101/544 (18%)
Query: 55 KIREQELKSLRSQLDVT-HKEVGMLHQQVEEHEK-IKQEMT---------MEYKQELKKL 103
K+ +Q+ +L L+++ K+ G + +E EK +K E+ +E +L KL
Sbjct: 90 KLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKL 149
Query: 104 HEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTA----KIEEFRQKSLDWEKQ 159
E L SY K+ K + E N + +EIE + K++ R +L K
Sbjct: 150 RE----LNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKI 205
Query: 160 RLIYQQQVSSLEAQRKALA----------------------EQSEIIQAQLVNRKQKLES 197
+ Q +S L+ + ++ E ++ Q V + + E+
Sbjct: 206 SSL--QDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEA 263
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRE 257
E S E++ L LE+ +E E L + T E+ + ++KL +
Sbjct: 264 FERFSLEEVERLERDLEK-------KMIETEELKSK--------QTRFLEEIKNQDKLNK 308
Query: 258 SEKLLEALQEEK-RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESL 316
S K LQ++ ELK+ L ++ L+ + I+ + +K + A I + E L
Sbjct: 309 SLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPL 368
Query: 317 AEKKYTSQGQGDLDSVLSQLNFTHTS--EDLLQAEVTCLEGSLESVSATCKQ-------- 366
Y ++D + + S + + A + + S ++V +
Sbjct: 369 ---NYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRND 425
Query: 367 ---------LSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKM-E 416
L +L +K +++ + +E EI+K ++QIL+ + + E +++ +
Sbjct: 426 HMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKK 485
Query: 417 ISHLTQELHQRDIT-----IASTKGSSSDMEKRLRAEMQKAEDKAVEHKEI---LDQLES 468
IS ++L + ++ + + + D+E ++ + Q+ K E K++ +D L+S
Sbjct: 486 ISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDS 545
Query: 469 LKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKR 528
++ H+ E L I + ++ E R IL R+ EE+K
Sbjct: 546 KDPKHSHMKAQKSGKEQQL-----------DIMNKQYQQLESRLDEILSRIAKETEEIKD 594
Query: 529 ESEK 532
E+
Sbjct: 595 LEEQ 598
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 97.4 bits (241), Expect = 3e-20
Identities = 96/424 (22%), Positives = 196/424 (46%), Gaps = 52/424 (12%)
Query: 147 EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
+ F+ KS W++ IY++ ++ L+ + E I QL+ ++ L + E
Sbjct: 122 DAFQAKSTPWQED--IYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEK 179
Query: 207 QHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQ 266
+ +E++++ IC E E ERL ++ QE + +EEK +E EK + L+
Sbjct: 180 RKHKEYMEKSDEFICLLEQECERLKKLID----------QEIKSQEEKEQEKEKRVTTLK 229
Query: 267 EEKRELKA----ALQSQENLIHEARIQKEKLQE---KVKATNTQHAVEAIRPREE----S 315
EE +LK+ + Q+ L + +Q++K+QE K T+T+ A+ R +EE +
Sbjct: 230 EELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKAT 289
Query: 316 LAEKK---YTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLE---GSLESVSATCKQLSQ 369
EK+ T++ D D+++++L + LQ ++ L LE + + ++ +
Sbjct: 290 RLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE 349
Query: 370 ELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDI 429
EL + E++ + E N AE+++L++++L E ++ M+ + L + L + +
Sbjct: 350 ELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK-MEEQCRDLNKRLERETL 408
Query: 430 TIASTKGSSSDMEKRLRAEMQKAED------------------KAVEHKEILDQLESLKL 471
K + KR+ A ++K ED + + K++ +LESLK+
Sbjct: 409 QSKDFKLEVEKLSKRIMA-LEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 467
Query: 472 ENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHIL---ERLDAHIEELKR 528
+ L + +LE ++ L ++ F++E + S + ++L A +L+
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 529 ESEK 532
E K
Sbjct: 528 EQNK 531
Score = 77.4 bits (189), Expect = 3e-14
Identities = 115/567 (20%), Positives = 244/567 (43%), Gaps = 74/567 (13%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
+T+ + EL +L K +MV ++ L L ++ Q+++ L + TH ++ +
Sbjct: 225 VTTLKEELTKL-KSFALMVVDEQQR-------LTAQLTLQRQKIQELTTNAKETHTKLAL 276
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEE---------------------LCILKRSYEK 116
+V+E E+ + E + + K H++ L L R ++
Sbjct: 277 AEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE 336
Query: 117 LQK--KQMREFRGNTKNHREDRSEIER----LTAKIEEFRQKSLDWE---KQRLIYQQQV 167
L++ + +R+ ++ +E S+ E + A++EE R++ LD E ++ + ++Q
Sbjct: 337 LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQC 396
Query: 168 SSLEA--QRKALAEQSEIIQAQLVNRK----QKLESVELSSQSEIQHLSSKLERANDTIC 221
L +R+ L + ++ + ++++ +KLE S+ E L LE+ T
Sbjct: 397 RDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTK 456
Query: 222 ANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQEN 281
E+E L +R+ +L + + + +E L + + L +E++ + L+ E+
Sbjct: 457 QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTED 516
Query: 282 LIHEARIQKEKLQEKVKATNTQHAVEAIRPREES---LAEKKYTSQGQGDLDSVLSQLNF 338
+ A Q + Q KV T T+ +E + +S + EK Y+ + D + ++L
Sbjct: 517 KLQAASSQLQVEQNKV-TTVTEKLIEETKRALKSKTDVEEKMYSV--TKERDDLKNKLKA 573
Query: 339 THTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQ 398
+ L + V L+ L+S+ A K + + + H K IK+L ++
Sbjct: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNK--IKELSQE 631
Query: 399 I--LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRL-RAEMQKAEDK 455
+ L+ + A+E M+ + L +R A+ + + + K L +M+ A+ K
Sbjct: 632 VERLKLKLKDMKAIEDDLMKTEDEYETLERR---YANERDKAQFLSKELEHVKMELAKYK 688
Query: 456 AVEHKE------ILDQLESLKLENRHLSEMVMKLELGLHE--------CSLPVSPLGSIA 501
E E + +L+ + ++ HLS V L+ +HE C L S+
Sbjct: 689 LAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGD--HSVL 746
Query: 502 TRFLEEEELRSHHILERLDAHIEELKR 528
+ L ++E R+ + ++ +EL+R
Sbjct: 747 QKKLNQQENRNRDLGREIENLTKELER 773
Score = 73.2 bits (178), Expect = 6e-13
Identities = 99/478 (20%), Positives = 204/478 (42%), Gaps = 73/478 (15%)
Query: 60 ELKSLRSQLDVTHKEVGMLHQQVEEH--------------EKIKQEMTMEYKQE------ 99
+ KS Q D+ K + L + VE+H EK +++ +E ++E
Sbjct: 125 QAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKE 184
Query: 100 -LKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL---TAKIEEFRQKSLD 155
++K E +C+L++ E+L+K +E + + +E + L K++ F +D
Sbjct: 185 YMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVD 244
Query: 156 WEKQRL-----IYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLS 210
E+QRL + +Q++ L K + + +A++ +QK +E E+Q +
Sbjct: 245 -EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE----KELQTQT 299
Query: 211 SKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEE-- 268
+K + DTI A + ++ + + E ++ LR++E+ L+ ++E+
Sbjct: 300 TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 359
Query: 269 KREL-KAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQG 327
K E A + ++ + + + E E++ Q R E+L K + + +
Sbjct: 360 KGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVE- 418
Query: 328 DLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNE 387
L + L + + + E L+ +LE T KQLSQEL +K +EA +
Sbjct: 419 KLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESR 478
Query: 388 -------YKAEIKKLK--------------EQILQGE---QSYSSALEGMKMEISHLTQE 423
K ++ KLK E++ + E Q+ SS L+ + +++ +T++
Sbjct: 479 LEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEK 538
Query: 424 LHQR-----------DITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 470
L + + + S D++ +L+AE +K D + ++L+SL+
Sbjct: 539 LIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLE 596
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 97.4 bits (241), Expect = 3e-20
Identities = 96/424 (22%), Positives = 196/424 (46%), Gaps = 52/424 (12%)
Query: 147 EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
+ F+ KS W++ IY++ ++ L+ + E I QL+ ++ L + E
Sbjct: 122 DAFQAKSTPWQED--IYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEK 179
Query: 207 QHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQ 266
+ +E++++ IC E E ERL ++ QE + +EEK +E EK + L+
Sbjct: 180 RKHKEYMEKSDEFICLLEQECERLKKLID----------QEIKSQEEKEQEKEKRVTTLK 229
Query: 267 EEKRELKA----ALQSQENLIHEARIQKEKLQE---KVKATNTQHAVEAIRPREE----S 315
EE +LK+ + Q+ L + +Q++K+QE K T+T+ A+ R +EE +
Sbjct: 230 EELTKLKSFALMVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKAT 289
Query: 316 LAEKK---YTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLE---GSLESVSATCKQLSQ 369
EK+ T++ D D+++++L + LQ ++ L LE + + ++ +
Sbjct: 290 RLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEE 349
Query: 370 ELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDI 429
EL + E++ + E N AE+++L++++L E ++ M+ + L + L + +
Sbjct: 350 ELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIK-MEEQCRDLNKRLERETL 408
Query: 430 TIASTKGSSSDMEKRLRAEMQKAED------------------KAVEHKEILDQLESLKL 471
K + KR+ A ++K ED + + K++ +LESLK+
Sbjct: 409 QSKDFKLEVEKLSKRIMA-LEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKV 467
Query: 472 ENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHIL---ERLDAHIEELKR 528
+ L + +LE ++ L ++ F++E + S + ++L A +L+
Sbjct: 468 RIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQV 527
Query: 529 ESEK 532
E K
Sbjct: 528 EQNK 531
Score = 77.4 bits (189), Expect = 3e-14
Identities = 115/567 (20%), Positives = 244/567 (43%), Gaps = 74/567 (13%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
+T+ + EL +L K +MV ++ L L ++ Q+++ L + TH ++ +
Sbjct: 225 VTTLKEELTKL-KSFALMVVDEQQR-------LTAQLTLQRQKIQELTTNAKETHTKLAL 276
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEE---------------------LCILKRSYEK 116
+V+E E+ + E + + K H++ L L R ++
Sbjct: 277 AEARVQEEEQKATRLEKELQTQTTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDE 336
Query: 117 LQK--KQMREFRGNTKNHREDRSEIER----LTAKIEEFRQKSLDWE---KQRLIYQQQV 167
L++ + +R+ ++ +E S+ E + A++EE R++ LD E ++ + ++Q
Sbjct: 337 LEETNRSLRKAEEELQDIKEKISKGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQC 396
Query: 168 SSLEA--QRKALAEQSEIIQAQLVNRK----QKLESVELSSQSEIQHLSSKLERANDTIC 221
L +R+ L + ++ + ++++ +KLE S+ E L LE+ T
Sbjct: 397 RDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTK 456
Query: 222 ANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQEN 281
E+E L +R+ +L + + + +E L + + L +E++ + L+ E+
Sbjct: 457 QLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTED 516
Query: 282 LIHEARIQKEKLQEKVKATNTQHAVEAIRPREES---LAEKKYTSQGQGDLDSVLSQLNF 338
+ A Q + Q KV T T+ +E + +S + EK Y+ + D + ++L
Sbjct: 517 KLQAASSQLQVEQNKV-TTVTEKLIEETKRALKSKTDVEEKMYSV--TKERDDLKNKLKA 573
Query: 339 THTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQ 398
+ L + V L+ L+S+ A K + + + H K IK+L ++
Sbjct: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKNKLNQDSGKSTTALHQENNK--IKELSQE 631
Query: 399 I--LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRL-RAEMQKAEDK 455
+ L+ + A+E M+ + L +R A+ + + + K L +M+ A+ K
Sbjct: 632 VERLKLKLKDMKAIEDDLMKTEDEYETLERR---YANERDKAQFLSKELEHVKMELAKYK 688
Query: 456 AVEHKE------ILDQLESLKLENRHLSEMVMKLELGLHE--------CSLPVSPLGSIA 501
E E + +L+ + ++ HLS V L+ +HE C L S+
Sbjct: 689 LAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEKIHEYMATEDLICHLQGD--HSVL 746
Query: 502 TRFLEEEELRSHHILERLDAHIEELKR 528
+ L ++E R+ + ++ +EL+R
Sbjct: 747 QKKLNQQENRNRDLGREIENLTKELER 773
Score = 73.2 bits (178), Expect = 6e-13
Identities = 99/478 (20%), Positives = 204/478 (42%), Gaps = 73/478 (15%)
Query: 60 ELKSLRSQLDVTHKEVGMLHQQVEEH--------------EKIKQEMTMEYKQE------ 99
+ KS Q D+ K + L + VE+H EK +++ +E ++E
Sbjct: 125 QAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKHKE 184
Query: 100 -LKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL---TAKIEEFRQKSLD 155
++K E +C+L++ E+L+K +E + + +E + L K++ F +D
Sbjct: 185 YMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMVVD 244
Query: 156 WEKQRL-----IYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLS 210
E+QRL + +Q++ L K + + +A++ +QK +E E+Q +
Sbjct: 245 -EQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLE----KELQTQT 299
Query: 211 SKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEE-- 268
+K + DTI A + ++ + + E ++ LR++E+ L+ ++E+
Sbjct: 300 TKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKIS 359
Query: 269 KREL-KAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQG 327
K E A + ++ + + + E E++ Q R E+L K + + +
Sbjct: 360 KGEYGNAGIMAEVEELRKRVLDMEGKDEELIKMEEQCRDLNKRLERETLQSKDFKLEVE- 418
Query: 328 DLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNE 387
L + L + + + E L+ +LE T KQLSQEL +K +EA +
Sbjct: 419 KLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERMTTKQLSQELESLKVRIKELEAIESR 478
Query: 388 -------YKAEIKKLK--------------EQILQGE---QSYSSALEGMKMEISHLTQE 423
K ++ KLK E++ + E Q+ SS L+ + +++ +T++
Sbjct: 479 LEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEK 538
Query: 424 LHQR-----------DITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 470
L + + + S D++ +L+AE +K D + ++L+SL+
Sbjct: 539 LIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLE 596
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 94.0 bits (232), Expect = 3e-19
Identities = 128/586 (21%), Positives = 258/586 (44%), Gaps = 100/586 (17%)
Query: 21 CEAELQELMKQIDIMV-AH--------------KKSEWEGRTHALETCLKIR---EQELK 62
CE E + L+K +I+ AH K++E E + L LK R E+EL
Sbjct: 649 CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708
Query: 63 SLRSQLDVTHKEV-GMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQK-- 119
L+ Q D +E+ + +Q H++ + E++ +++ + L E L K
Sbjct: 709 VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
Query: 120 -KQMREFRGNTKNHRED----RSEIERLTAKIEEFR---------------------QKS 153
K ++E + + +N D E+++ +AK++ F+ QK
Sbjct: 769 DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828
Query: 154 LDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLS--- 210
LD E +R++ +QV+ +EAQ+K + + + + Q+ + Q+LE + +++ L+
Sbjct: 829 LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888
Query: 211 -SKLERANDTICANE---LEIERLTMRVNDLVGTSMTVLQEQ------------QQKEEK 254
SKLE N + +E E + +++ + + +L ++ ++ E K
Sbjct: 889 ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETK 948
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREE 314
+ EK +E ++++ +E+ QE L + Q+ KL+++++ T + + + + +
Sbjct: 949 FKNQEKKMEKVKQKAKEM------QETLKKKLLDQEAKLKKELENTALELSQKEKQFNAK 1002
Query: 315 SLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEK 374
L + S G D S L + N E L + L + Q ++EL E
Sbjct: 1003 MLEMAQANSAGISDAVSRL-ETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI 1061
Query: 375 YEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAST 434
+ E E + E+ +LK++IL + E M EI+ L +E ++D T+
Sbjct: 1062 H------EIQLQEKEQEVAELKQKIL----LFGCEKEEMNKEITWLKEEGVKQDTTL--- 1108
Query: 435 KGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKL-------ENRHLSEMVMKLELGL 487
++++++L+ + A + ++ LE L++ EN L E +++L++
Sbjct: 1109 ----NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLA 1164
Query: 488 HECSLPVSPLGS-IATRFLEEEELRSHHILERLDAHIEELKRESEK 532
E VS L S + T E + L+S H E+ + +E+ E +K
Sbjct: 1165 EEDKRKVSELTSKLKTTDEEFQSLKSSH--EKSNKSLEDKSLEFKK 1208
Score = 81.3 bits (199), Expect = 2e-15
Identities = 110/565 (19%), Positives = 245/565 (43%), Gaps = 77/565 (13%)
Query: 5 LEGIQNR-GHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIRE----- 58
LE +Q R L C+ +Q +Q ++ + K++ E L+ KI++
Sbjct: 281 LETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAE 340
Query: 59 -----QELKSLRSQLDVTHKEVGML----HQQVEEHEKIKQEMTMEYKQELKKLHEELCI 109
+L+ ++ ++ ++ GM+ +Q+ E ++K+E + + +K++ +
Sbjct: 341 KTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE 400
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI-EEFRQKSLDWEKQRLIYQQQVS 168
L+ EK ++ E ++ +L A++ E+ + E++R+ QQ++S
Sbjct: 401 LREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELS 460
Query: 169 SLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLE------RANDTICA 222
++ + + ++S + + + QKL EL+ + Q L+ KL+ + +
Sbjct: 461 RVKQEVVDVMKKS---SEEQIAKLQKLHEKELARKE--QELTKKLQTREREFQEQMKVAL 515
Query: 223 NELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENL 282
+ + E L + S+ + + + QK+ L ESE L LQ+E + + E+
Sbjct: 516 EKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESS 575
Query: 283 IHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTS 342
+ E +Q+ K Q K A + + + EK T +L+S+ Q + T
Sbjct: 576 L-EKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKT-----ELESLKHQQDALWTE 629
Query: 343 EDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 402
+ LQ + +E + C+Q + L++ E + ++A I+++ E+ L+
Sbjct: 630 K--LQVLKQQYQTEMEKLREKCEQEKETLLKDKEII---------FQAHIEEMNEKTLEK 678
Query: 403 EQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEI 462
+ LE + E+S + + H+ + ++ K + M++ L A+M + ++ H++
Sbjct: 679 LDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN---HHQQQ 735
Query: 463 LDQL-----ESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILE 517
+D + S++ + L + + +LEL L E ++ L+ H
Sbjct: 736 VDSIIKEHEVSIQRTEKALKDQINQLELLLKE----------------RDKHLKEH---- 775
Query: 518 RLDAHIEELK---RESEKTVRQFTA 539
AH+E L+ + SE ++Q +A
Sbjct: 776 --QAHVENLEADIKRSEGELQQASA 798
Score = 76.6 bits (187), Expect = 5e-14
Identities = 120/590 (20%), Positives = 256/590 (43%), Gaps = 99/590 (16%)
Query: 24 ELQELMKQIDIM---VAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQ 80
EL + K+ D + + KS+ E + LET LK + + L + E+ L++
Sbjct: 1487 ELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNE 1546
Query: 81 QVEEHEKIK--------------QEMTMEYKQELKKLHEELCILKRSYEKL------QKK 120
++ + + K QE+ E +K+ E++ L+ + +KK
Sbjct: 1547 VLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
Query: 121 QMREFRGNTKNHREDRSEIE-----RLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRK 175
++ + K+ E+ +E AK+ E ++K+ +K I +Q +S +E + +
Sbjct: 1607 ELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKA--EQKIAAIKKQLLSQMEEKEE 1664
Query: 176 ALAEQSEIIQAQLVNR-----------KQKLESVELSSQSE--IQHLSSK-------LER 215
+ +E ++L + ++KL+SVE SSQSE I S+K E
Sbjct: 1665 QYKKGTESHLSELNTKLQEREREVHILEEKLKSVE-SSQSETLIVPRSAKNVAAYTEQEE 1723
Query: 216 ANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAA 275
A+ C + E++++ +L + + Q+KEE + ++ QE +L+ A
Sbjct: 1724 ADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHA 1783
Query: 276 LQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQ 335
Q HE + LQE+++ N ++++ + E+ K Q + +L++V
Sbjct: 1784 EAKQ----HEDQSMIGHLQEELEEKNKKYSLIVAQHVEKE--GGKNNIQAKQNLENVFDD 1837
Query: 336 LNFTHTSEDL----LQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRME--------- 382
+ T ++L L+ ++ L+ L + +EL KYE+L+ ++
Sbjct: 1838 VQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPT 1897
Query: 383 ---AHNNEYKAEIKKLKEQILQGEQSYSSALE----GMKMEISHLTQEL----------- 424
N E K++ ++ ++L ++ + LE G + E L +E+
Sbjct: 1898 ELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLR 1957
Query: 425 --HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMK 482
HQ+++ I K + E++++ Q+ ED ++H L QL ++ N L++ +
Sbjct: 1958 KEHQQELEILK-KEYDQEREEKIK---QEQEDLELKHNSTLKQL--MREFNTQLAQKEQE 2011
Query: 483 LELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEK 532
LE+ + E ++ + LE + ++ +L+++ ++LKR +++
Sbjct: 2012 LEMTIKE---TINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKR 2058
Score = 70.1 bits (170), Expect = 5e-12
Identities = 98/486 (20%), Positives = 212/486 (43%), Gaps = 55/486 (11%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHAL------ETCLKIREQELKSLRSQLDVT 71
L+ +LQE +++ I+ KS ++ L + EQE + + T
Sbjct: 1674 LSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKT 1733
Query: 72 HKE-VGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTK 130
++E + +L + + E EK+ Q + E ++ + E C + KL+ + ++
Sbjct: 1734 YEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQ------ 1787
Query: 131 NHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVN 190
ED+S I L ++EE +K LI Q V + A+Q+ ++ +
Sbjct: 1788 --HEDQSMIGHLQEELEEKNKK------YSLIVAQHVEKEGGKNNIQAKQN--LENVFDD 1837
Query: 191 RKQKLESVELSSQ---SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMT---- 243
++ L+ EL+ Q +I+ L S L R + + +E+E LT + L
Sbjct: 1838 VQKTLQEKELTCQILEQKIKELDSCLVRQKEV---HRVEMEELTSKYEKLQALQQMDGRN 1894
Query: 244 ----VLQEQQQKEEKLRESE-KLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK 298
+L+E +++ K + KLL ++ + +L+ L E + + +LQ+ ++
Sbjct: 1895 KPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLR 1954
Query: 299 ATNTQHAVEA-IRPREESLAEKKYTSQGQGDLD----SVLSQLNFTHTSEDLLQAEVTCL 353
+H E I +E ++ Q Q DL+ S L QL + L Q E L
Sbjct: 1955 MLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQL-MREFNTQLAQKEQE-L 2012
Query: 354 EGSLESVSATCKQLSQELMEKYEE-----LKRMEAHNNEYKAEIKKLKEQILQGEQSYSS 408
E +++ +++ EL+E ++E LK++ +++ K K+ +E + E+ ++
Sbjct: 2013 EMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Query: 409 ALEGMKMEISHLTQELHQRDITIASTKGSSS----DMEKRLRAEMQKAEDKAVEHKEILD 464
+ ++ ++ L Q+ +Q+ + G+ + +++ +L + D ++ +E +
Sbjct: 2073 KVRDLQTQLEEL-QKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFRE 2131
Query: 465 QLESLK 470
Q+ +L+
Sbjct: 2132 QIHNLE 2137
Score = 66.2 bits (160), Expect = 7e-11
Identities = 136/663 (20%), Positives = 262/663 (39%), Gaps = 140/663 (21%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSL----RSQLDVTHK 73
LT AE++ K + + K + + LE EQ++KSL S+L+ +K
Sbjct: 838 LTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK 897
Query: 74 EVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELC-------ILKRSYE---KLQKKQMR 123
E Q + E E + +M K+E++ L ++L IL YE K Q+K+M
Sbjct: 898 EQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKME 957
Query: 124 EFRGNTKNHRED------------RSEIE----RLTAKIEEFRQKSLDW----------- 156
+ + K +E + E+E L+ K ++F K L+
Sbjct: 958 KVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDA 1017
Query: 157 -EKQRLIYQQQVSSL-EAQRKALAEQSEIIQAQLVNRKQKLESVE----LSSQSEIQHLS 210
+ ++Q+ SL E R+ L + I + +L + ++L+ + + E+ L
Sbjct: 1018 VSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELK 1077
Query: 211 SKL-------------------ERANDTICANEL--EIERLTMRVNDLVGTSMTVLQEQQ 249
K+ E NEL ++++ + VN L + +
Sbjct: 1078 QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLE 1137
Query: 250 QKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAI 309
+ E L +S K LQE+ ELK + + + E + + E+ ++ + H
Sbjct: 1138 KLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNK 1197
Query: 310 RPREESLAEKKYTSQGQGDLD--------------------------SVLSQLNF----- 338
++SL KK + + LD ++LS+++
Sbjct: 1198 SLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRT 1257
Query: 339 THTSEDLL---------QAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYK 389
T E LL +A++ L +++ + +Q + +L EK ++K M+A
Sbjct: 1258 TKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLV 1317
Query: 390 AEIKKLKEQILQGEQSYS---SALEGMKMEISH-------LTQELHQRDITIASTKGSSS 439
E + L+++ +Q+ S S + +K E+S + +EL ++ + I+S +
Sbjct: 1318 TEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT 1377
Query: 440 DMEKRLRAEMQKAEDKAV----------EHKEILDQLESLKLENRHLSEMVMKLELGLHE 489
D+ +L+ + +E +A E E+LDQ++ L + LS+ + + +
Sbjct: 1378 DLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDD 1437
Query: 490 CSLPVSPLGSIA-TRFLEEE----------ELRSHHILERLDAHIEELKRESEKTVRQFT 538
S S A +RF + + EL+S E+ D I LK E ++ ++F
Sbjct: 1438 WSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEK-DEQINLLKEELDQQNKRFD 1496
Query: 539 ALK 541
LK
Sbjct: 1497 CLK 1499
Score = 64.7 bits (156), Expect = 2e-10
Identities = 113/536 (21%), Positives = 229/536 (42%), Gaps = 96/536 (17%)
Query: 41 SEWEGRTHALETCLKIREQELKSLRSQL----DVTHKEVGMLHQQVEEHEKIKQEMTMEY 96
S + G+ L T ++ ++E K L+ L D + + + L ++++ ++ K+ + E+
Sbjct: 151 SSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEF 210
Query: 97 KQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDW 156
L++ + + +L+ L K+++R N + + + +L + E F ++
Sbjct: 211 DASLEEKDQYISVLQTQVSLL-KQRLR----NGPMNVDVLKPLPQLEPQAEVFTKEE--- 262
Query: 157 EKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERA 216
+ E+ + + E ++ LE++ Q ++ + L+R
Sbjct: 263 ------------NPESDGEPVVEDGTSVKT--------LETL----QQRVKRQENLLKRC 298
Query: 217 NDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAAL 276
+TI +++ + LT L Q+Q +E+L+E EK+ + EK +L L
Sbjct: 299 KETIQSHKEQCTLLTSEKEAL----------QEQLDERLQELEKIKDLHMAEKTKLITQL 348
Query: 277 QSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAE-----KKYTSQGQ----- 326
+ +NLI Q E+ + V A + E + +EE +A+ K+ T+QG+
Sbjct: 349 RDAKNLIE----QLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQ 404
Query: 327 ---------GDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQ----LSQELME 373
+L+ LS T + L+AE ++ ++++ T ++ L QEL
Sbjct: 405 KEKSERAAFEELEKALSTAQKTEEARRKLKAE---MDEQIKTIEKTSEEERISLQQELSR 461
Query: 374 -KYEELKRMEAHNNEYKAEIKKLKE-QILQGEQSYSSALEGMKMEISHLTQELHQRDITI 431
K E + M+ + E A+++KL E ++ + EQ + L+ + E Q + +
Sbjct: 462 VKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREF--------QEQMKV 513
Query: 432 ASTKGSSSDMEKRLRAEMQKA---EDKAVEHKEIL----DQLESLKLENRHLSEMVMKLE 484
A K S ++ E Q++ E+ ++ K IL ++L L+ E +++LE
Sbjct: 514 ALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELE 573
Query: 485 LGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL 540
L E SL + S E E H+ + + +E+ K E E Q AL
Sbjct: 574 SSL-EKSLQENKNQSKDLAVHLEAEKNKHN--KEITVMVEKHKTELESLKHQQDAL 626
Score = 62.8 bits (151), Expect = 8e-10
Identities = 108/558 (19%), Positives = 240/558 (43%), Gaps = 111/558 (19%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALE---TCLKIREQELKSLRSQLDVTHKE 74
++ EA+L++L ++ + + ++ TH LE +K + +++SL ++ + KE
Sbjct: 1271 VSELEAQLRQLTEEQNTL----NISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKE 1326
Query: 75 VGMLHQQVEEHE----KIKQEMTMEY------KQELKKLHEELCILKRSYEKLQ------ 118
G Q E E ++K+E++ K+ELK+ E+ L + L
Sbjct: 1327 GGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNS 1386
Query: 119 ---KKQMREFRGNTKNHREDRSEI----------------ERLTA--KIEEFRQKSLDWE 157
++ K + E++ E+ E+++A +++++ K +W+
Sbjct: 1387 ISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK 1446
Query: 158 KQ-------------RLIYQQQVSSLEAQRK---------ALAEQS---EIIQAQLVNRK 192
K+ L Q ++ S EA K L +Q+ + ++ ++ + K
Sbjct: 1447 KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDK 1506
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLT-----------MRVNDLVGTS 241
K+E E + ++E++ ++++ D I +EIE L + +LV
Sbjct: 1507 SKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKL 1566
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKA-- 299
+ ++K+ +++E+E+ + L+ + +KA L++++ + + + +E++KA
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALE 1626
Query: 300 ---------------TNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSED 344
+ + AI+ + S E+K +G +S LS+LN T
Sbjct: 1627 DRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKG-TESHLSELN---TKLQ 1682
Query: 345 LLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQ 404
+ EV LE L+SV ++ E + K + A+ + +A+ + ++ + +
Sbjct: 1683 EREREVHILEEKLKSVESS----QSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEK- 1737
Query: 405 SYSSALEGMKMEISHLTQELHQ-RDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEIL 463
S L+ E L Q + Q ++ T++S ++RL +++ AE K E + ++
Sbjct: 1738 --ISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERL-IKLEHAEAKQHEDQSMI 1794
Query: 464 DQL-ESLKLENRHLSEMV 480
L E L+ +N+ S +V
Sbjct: 1795 GHLQEELEEKNKKYSLIV 1812
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 93.6 bits (231), Expect = 4e-19
Identities = 118/536 (22%), Positives = 228/536 (42%), Gaps = 73/536 (13%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E EL +++ + KK E E H LE ++ E+ + L+++ + + L +Q
Sbjct: 892 ETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQ 951
Query: 82 VEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQ------MREFRGNTKNH 132
+EE E +Q++ +E + +LKKL EE IL+ KL K++ + EF N
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 133 REDRSEIERLTAK----IEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQL 188
E + +L K I + ++ EKQR ++ LE L++Q +QAQ+
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQ 248
K +L E Q+ + + + + N + +I L ++++L + +
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMAL----KKIRELESQISELQEDLESERASR 1127
Query: 249 QQKEEKLRESEKLLEALQEEKRELKAALQSQENL----IHEARIQKEKLQEKVKATNTQH 304
+ E++ R+ + LEAL+ E + + +Q+ L E I K+ L+E+ K Q
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ- 1186
Query: 305 AVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATC 364
++ +R + E+ + QL T + L+ LE ++
Sbjct: 1187 -IQEMRQKHSQAVEE------------LAEQLEQTKRVKANLEKAKQTLENERGELANEV 1233
Query: 365 KQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQ---SYSSALEGMKMEISHLT 421
K L Q + + K++E A++++L+ + +GE+ + + +++E+ ++T
Sbjct: 1234 KVLLQGKGDSEHKRKKVE-------AQLQELQVKFNEGERVRTELADKVTKLQVELDNVT 1286
Query: 422 QELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVM 481
L Q D SS + K D + ++ D E L+ ENR +
Sbjct: 1287 GLLSQSD-------SKSSKLTK----------DFSALESQLQDTQELLQEENRQKLSLST 1329
Query: 482 KLELGLHECSLPVSPLGSIATRFLEEEELRSHHI---LERLDAHIEELKRESEKTV 534
KL+ V + LEEEE H++ + L A + ++K++ E +V
Sbjct: 1330 KLK--------QVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSV 1377
Score = 70.5 bits (171), Expect = 4e-12
Identities = 97/455 (21%), Positives = 182/455 (40%), Gaps = 93/455 (20%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E + ++L++Q+ M A + E + R+ A+ K+ E +LK L + +D +K
Sbjct: 1581 EEKKKQLVRQVREMEAELEDERKQRSMAVAARKKL-EMDLKDLEAHIDSANKN------- 1632
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
E IKQ L+KL ++ K MRE + R+ E
Sbjct: 1633 --RDEAIKQ---------LRKLQAQM-----------KDCMRELD-------DTRASREE 1663
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLE-AQRKALAEQSEIIQ---------AQLVNR 191
+ A+ +E +K E + + Q+++++ E A+R+A E+ E+ A +
Sbjct: 1664 ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723
Query: 192 KQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
K++LE+ + E++ E ND + L+I D + T + + + QK
Sbjct: 1724 KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQI--------DQINTDLNLERSHAQK 1775
Query: 252 EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV---EA 308
E R+ L+ + +ELK LQ E + K K + + A + A +
Sbjct: 1776 NENARQQ------LERQNKELKVKLQEMEGTV------KSKYKASITALEAKIAQLEEQL 1823
Query: 309 IRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLS 368
+E A K + + L VL Q++ + + + + + S KQL
Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQA-------DKASTRLKQLK 1876
Query: 369 QELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRD 428
++L E EE +R A + + E++ E + M E+S L +L + D
Sbjct: 1877 RQLEEAEEEAQRANASRRKLQRELEDATE-----------TADAMNREVSSLKNKLRRGD 1925
Query: 429 ITIA-----STKGSSSDMEKRLRAEMQKAEDKAVE 458
+ + KG+ ++ + + AE K E
Sbjct: 1926 LPFVVPRRMARKGAGDGSDEEVDGKADGAEAKPAE 1960
Score = 67.8 bits (164), Expect = 2e-11
Identities = 103/545 (18%), Positives = 231/545 (42%), Gaps = 62/545 (11%)
Query: 16 GFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEV 75
G L + E ++L K ++ + + + E LE +QEL L LD +
Sbjct: 1378 GCLETAEEVKRKLQKDLEGL-SQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSA 1436
Query: 76 GMLHQQVEEHEKIKQE---MTMEYKQELKKLHEE--------LCILKRSYEKLQKKQMRE 124
L ++ ++ +++ E ++ +Y +E + E L + + E +++K E
Sbjct: 1437 CNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE 1496
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEII 184
+ +++ R+E+E L + ++ + + EK + +QQV ++ Q + L ++ +
Sbjct: 1497 -----RLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQAT 1551
Query: 185 QAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICAN------ELEIERLTMRV---- 234
+ + + L++++ + ++Q + E + ELE ER +
Sbjct: 1552 EDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAA 1611
Query: 235 -----NDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQ 289
DL + + ++E +++ KL +++ REL S+E ++ +A+
Sbjct: 1612 RKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKEN 1671
Query: 290 KEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAE 349
++KL+ E I+ +EE A ++ Q Q + D + ++ + L E
Sbjct: 1672 EKKLKSM--------EAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723
Query: 350 VTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSA 409
LE A QL +EL E+ + + + +I ++ L E+S++
Sbjct: 1724 KRRLE-------ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTD-LNLERSHAQK 1775
Query: 410 LEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHK--EILDQLE 467
E + ++ +EL K +ME ++++ KA A+E K ++ +QL+
Sbjct: 1776 NENARQQLERQNKEL----------KVKLQEMEGTVKSK-YKASITALEAKIAQLEEQLD 1824
Query: 468 SLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELK 527
+ E + + V + E L + L V A ++ ++ + S L++L +EE +
Sbjct: 1825 NETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTR-LKQLKRQLEEAE 1883
Query: 528 RESEK 532
E+++
Sbjct: 1884 EEAQR 1888
Score = 63.2 bits (152), Expect = 6e-10
Identities = 77/403 (19%), Positives = 182/403 (45%), Gaps = 32/403 (7%)
Query: 152 KSLDWEKQRLIYQQ----QVSSLEAQRKALAEQS-EIIQAQLV--NRKQKLESVELSSQS 204
K +W+ RL + QVS E + A E+ ++ + QL NR ++E+++ +
Sbjct: 821 KLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA 880
Query: 205 EIQHLSSKLERANDTICANELEIE-RLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLE 263
E L +L+ A +CA E+ RLT + +L + +++EE+ + + +
Sbjct: 881 EKLQLQEQLQ-AETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 264 ALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTS 323
+Q+ +EL+ L+ +E+ + +++K + K+K + + + + LA++K
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQII--LEDQNCKLAKEKKL- 996
Query: 324 QGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEEL----K 379
L+ +++ T E+ + L+ E++ ++ + ++ +EL +
Sbjct: 997 -----LEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 380 RMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT---IASTKG 436
++E + + +I +L+ QI + + + E ++ ++ + +E Q+++ I +
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111
Query: 437 SSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSP 496
S++++ L +E + +++ ++LE+LK E E + E
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTE----LEDTLDSTAAQQELRSKREQ 1167
Query: 497 LGSIATRFLEEE----ELRSHHILERLDAHIEELKRESEKTVR 535
+I + LEEE E + + ++ +EEL + E+T R
Sbjct: 1168 EVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR 1210
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 93.6 bits (231), Expect = 4e-19
Identities = 105/478 (21%), Positives = 221/478 (46%), Gaps = 46/478 (9%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L+ + EL++ + + + + L ++ ++QEL L+ Q ++
Sbjct: 478 LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQ---AKEKQAQ 534
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRS 137
L Q +++ E+ Q + + +Q L K +++Q++E + R+D +
Sbjct: 535 LAQTLQQQEQASQGLRHQVEQLSSSL------------KQKEQQLKEVAEKQEATRQDHA 582
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
++L EE R+ SL ++R + LEA K A + EI+Q QL + +S
Sbjct: 583 --QQLATAAEE-REASL---RER---DAALKQLEALEKEKAAKLEILQQQLQVANEARDS 633
Query: 198 VELS---SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEK 254
+ S +Q E LS K+E + E +V +L + Q+ +KE
Sbjct: 634 AQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERV 693
Query: 255 LRESEKL---LEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRP 311
+E ++L L+AL+E + K +L+ ++ +A ++++ ++KA T+ VE +
Sbjct: 694 AQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKA-ETRSLVEQHKR 752
Query: 312 REESLAEKKYTSQGQGDLDSVLSQLNFTHTSE-DLLQAEVTCLEGSLESVSATCKQLSQE 370
+ L E++ G+ L++ L QL H +E ++L+ E+ + + + C+QL +E
Sbjct: 753 ERKELEEER---AGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKE 809
Query: 371 L---MEKYEELKRMEA-HNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQ 426
+ E+YE+ ++ EA + ++ ++ LKE+ + Q A E + SH
Sbjct: 810 VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESH------- 862
Query: 427 RDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLE 484
++ I+ + +++ L +Q+ ++K V +++ D L +L+ + S+ V +LE
Sbjct: 863 SELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLE 920
Score = 85.5 bits (210), Expect = 1e-16
Identities = 103/438 (23%), Positives = 198/438 (45%), Gaps = 56/438 (12%)
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKK-----LHEELCILKRSYEKLQKK--QMREFRGNTK 130
L++ EEH K QE +E + +L+K L ++ C+ +++ E LQ K Q+ E +
Sbjct: 341 LNELTEEHSKATQEW-LEKQAQLEKELSAALQDKKCLEEKN-EILQGKLSQLEEHLSQLQ 398
Query: 131 -NHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQR-----KALAEQSEI- 183
N +++ E+ ++E +Q++ Q +V LE +R K LAE+
Sbjct: 399 DNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE 458
Query: 184 ------------IQAQLVNRKQKLESVELSSQS-------EIQHLSSKLERANDTICANE 224
+Q+ + N Q E +E +SQ+ ++ L+S+L N TI +
Sbjct: 459 EEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQD 518
Query: 225 LEIERLTMRVNDLVGTSMTVLQEQQQKEEKLR-ESEKLLEALQEEKRELKAALQSQENLI 283
E+ L + + LQ+Q+Q + LR + E+L +L++++++LK + QE
Sbjct: 519 QELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE--- 575
Query: 284 HEARIQKEKLQEKVKATNTQHAVEAIRPREESLAE-KKYTSQGQGDLDSVLSQLNFTHTS 342
+++ Q+ A + A ++R R+ +L + + + L+ + QL + +
Sbjct: 576 ---ATRQDHAQQLATAAEEREA--SLRERDAALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 343 EDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 402
D Q VT + +S ++L + E R E H E +A++ +L+ Q L+
Sbjct: 631 RDSAQTSVTQAQREKAELSRKVEEL-----QACVETARQEQH--EAQAQVAELELQ-LRS 682
Query: 403 EQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEH--K 460
EQ ++ E + E L ++L ++ TKGS + EKR A+ + + + +
Sbjct: 683 EQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE-EKRRAADALEEQQRCISELKA 741
Query: 461 EILDQLESLKLENRHLSE 478
E +E K E + L E
Sbjct: 742 ETRSLVEQHKRERKELEE 759
Score = 83.6 bits (205), Expect = 4e-16
Identities = 121/513 (23%), Positives = 223/513 (43%), Gaps = 95/513 (18%)
Query: 80 QQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK--QMREFRGNTK-NHREDR 136
+++EE + +TM + LK+ + LK ++ +K Q+ E G+ RE
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQD----LKTEKSQMDRKINQLSEENGDLSFKLREFA 331
Query: 137 SEIERLTAKI----EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK 192
S +++L + EE + + +W +++ ++++S+ +K L E++EI+Q +L +
Sbjct: 332 SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE 391
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
+ L ++ + E K E D + L+ E T+ N+ T + E + E
Sbjct: 392 EHLSQLQDNPPQE------KGEVLGDVLQLETLKQEAATLAANN---TQLQARVEMLETE 442
Query: 253 EKLRESEKLLEA--LQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVE--- 307
+E++ L E +EEK++L + + ++ I KE+L++ +A + +
Sbjct: 443 RGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVAS 502
Query: 308 ----------AIRPREESLAE-KKYTSQGQGDLDSVLSQ-----LNFTHTSEDL---LQA 348
I+ +++ LA K+ + Q L L Q H E L L+
Sbjct: 503 LTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQ 562
Query: 349 EVTCLEGSLESVSATCKQLSQELMEKYEE-----------LKRMEAHNNEYKAEIKKLKE 397
+ L+ E AT + +Q+L EE LK++EA E A+++ L++
Sbjct: 563 KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQ 622
Query: 398 QILQGEQSYSSALEGM------KMEISHLTQELHQRDITIA-----STKGSSSDMEKRLR 446
Q+ ++ SA + K E+S +EL Q + A + +++E +LR
Sbjct: 623 QLQVANEARDSAQTSVTQAQREKAELSRKVEEL-QACVETARQEQHEAQAQVAELELQLR 681
Query: 447 AEMQKAEDK---AVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATR 503
+E QKA +K A E ++ +QL++LK SL V+ GS
Sbjct: 682 SEQQKATEKERVAQEKDQLQEQLQALKE-------------------SLKVTK-GS---- 717
Query: 504 FLEEEELRSHHILERLDAHIEELKRESEKTVRQ 536
LEEE+ R+ LE I ELK E+ V Q
Sbjct: 718 -LEEEKRRAADALEEQQRCISELKAETRSLVEQ 749
Score = 73.6 bits (179), Expect = 4e-13
Identities = 110/524 (20%), Positives = 216/524 (41%), Gaps = 80/524 (15%)
Query: 39 KKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQ 98
+K+E + L+ C++ QE ++Q+ ++ Q+ E E++ QE + ++
Sbjct: 644 EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKD-QLQE 702
Query: 99 ELKKLHEELCILKRSYEKLQKK-------QMR-------EFRGNTKNHREDRSEIE--RL 142
+L+ L E L + K S E+ +++ Q R E R + H+ +R E+E R
Sbjct: 703 QLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERA 762
Query: 143 TAKIEEFRQKSLDWEKQ---RLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVE 199
K E R + L Q ++ ++ ++ AQ A +E ++++ R++ +S +
Sbjct: 763 GRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQ 822
Query: 200 LSSQ-------------SEIQHLSSKLERANDTICA----NELEIERLTMRVNDLVGTSM 242
+Q E + +L+ A + + +EL+I R + +L
Sbjct: 823 EEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLA 882
Query: 243 TVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQ-----KEKLQEKV 297
LQ+ Q+KE + ++ L LQE+ + E L+ +A Q +E ++E
Sbjct: 883 RALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPA 942
Query: 298 KA----------------TNTQHAVEAIRPREESLAEK-------KYTSQGQGDLDSVLS 334
+A +TQ A++A+ E + + SQGQ +
Sbjct: 943 RAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQ 1002
Query: 335 QLNFTHTSED--LLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEI 392
+ +++ QA++ + + + + E ++ L+ AH K E
Sbjct: 1003 EREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEK-EG 1061
Query: 393 KKLKEQILQG-EQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKR------- 444
K + L+G E + LE ++ + L ++L +++ AS G+ S+ R
Sbjct: 1062 KDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPK 1121
Query: 445 ---LRAEMQKAEDKAVEHKEILDQLE-SLKLENRHLSEMVMKLE 484
LRAE+ K E + + +E D LE SL+ E +E LE
Sbjct: 1122 LEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALE 1165
Score = 72.8 bits (177), Expect = 8e-13
Identities = 126/586 (21%), Positives = 242/586 (41%), Gaps = 100/586 (17%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTH---ALETC---LKIREQELKSLRSQLDVT 71
++ E + Q+ +Q D + ++E R ALET L+ + QEL +S L
Sbjct: 1129 VSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASA 1188
Query: 72 HKEVGMLHQQVEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQMREFRGN 128
+E+ +V++H K + E + +QE ++ + + L+ L +Q+ E G
Sbjct: 1189 QRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSIL-NRQVLEKEGE 1247
Query: 129 TKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQL 188
+K E++RL E KS E++ + Q + +S A+ AE+S ++ ++
Sbjct: 1248 SK-------ELKRLVMAESE---KSQKLEERLRLLQAETASNSAR---AAERSSALREEV 1294
Query: 189 VNRKQKLESVELSSQSEIQHLSSKLERAND-----------------TICANELEIERLT 231
+ +++ E ++S++ Q L+S+ ERA + + +LE
Sbjct: 1295 QSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQ 1354
Query: 232 MRVNDLVGTS--MTVLQEQQQKEEKLRESE-------------KLLEALQE--EKRELKA 274
V++L+ LQ +Q EK E +LL A +E E L+
Sbjct: 1355 ALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQ 1414
Query: 275 ALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLS 334
+ QE + R +K E++ H + A EE+ + + G+ L+ L
Sbjct: 1415 KVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLA----EENRGLGERANLGRQFLEVELD 1470
Query: 335 QLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQEL-----------MEKYEELKRMEA 383
Q + E L A E L V + ++EL ++ EE +R +
Sbjct: 1471 QAREKYVQE--LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQE 1528
Query: 384 HNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDME- 442
+ A++++L ++ Q EQ+ K+ S ++ Q+ + +G S E
Sbjct: 1529 ERQKLTAQVEQL--EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEA 1586
Query: 443 KRLRAEMQKAE------DKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSP 496
+RL+A++ + + ++A EH ++ Q+E K + +L+
Sbjct: 1587 QRLQAQLNELQAQLSQKEQAAEHYKL--QMEKAKTHYDAKKQQNQELQ----------EQ 1634
Query: 497 LGSIATRFLEEEELRSHHILERLDAHIEEL---KRESEKTVRQFTA 539
L S+ E +ELR+ ERL +++ +E+E+T R TA
Sbjct: 1635 LRSLEQLQKENKELRAE--AERLGHELQQAGLKTKEAEQTCRHLTA 1678
Score = 67.8 bits (164), Expect = 2e-11
Identities = 117/539 (21%), Positives = 239/539 (44%), Gaps = 66/539 (12%)
Query: 22 EAELQE---LMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGML 78
EA L+E +KQ++ + K ++ E L+ L++ + S ++ + +E L
Sbjct: 593 EASLRERDAALKQLEALEKEKAAKLE----ILQQQLQVANEARDSAQTSVTQAQREKAEL 648
Query: 79 HQQVEEHEKIKQEMTMEYKQELKKLHE-ELCILKRSYEKLQKKQMREFRGNTKNHREDRS 137
++VEE + + E + ++ E EL + + +K+++ + + + +
Sbjct: 649 SRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALK 708
Query: 138 EIERLT-AKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLE 196
E ++T +EE ++++ D +++ Q+ +S L+A+ ++L EQ + + +L + +
Sbjct: 709 ESLKVTKGSLEEEKRRAADALEEQ---QRCISELKAETRSLVEQHKRERKELEEERAGRK 765
Query: 197 SVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLR 256
+E + +Q L A++ E E L + + + T E +Q +++
Sbjct: 766 GLE----ARLQQLGE----------AHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA 811
Query: 257 ESEKLLEALQEEKRELKAALQSQENLIHE----ARIQKEKLQEKVKATNTQHAVEAIRPR 312
+ E Q+E+ + A Q Q + E AR + ++ +EKV + ++ R +
Sbjct: 812 AWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQ 871
Query: 313 EESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLS--QE 370
E LAE +L L Q+ L +++ L+ E ++AT K+++ +
Sbjct: 872 NE-LAEL------HANLARALQQVQEKEVRAQKLADDLSTLQ---EKMAATSKEVARLET 921
Query: 371 LMEKYEELKRMEAHNNEYKAEIKK--------LKEQILQGEQ--SYSSALEGMKMEISHL 420
L+ K E + E + E E + L+EQ QG Q S +AL+ M+ E +
Sbjct: 922 LVRKAGE--QQETASRELVKEPARAGDRQPEWLEEQ--QGRQFCSTQAALQAMEREAEQM 977
Query: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
EL + + ++G E+R + E + A + D L LE +E+
Sbjct: 978 GNELERLRAALMESQGQQQ--EERGQQEREVARLTQERGRAQAD----LALEKAARAELE 1031
Query: 481 MKLELGLHECSLPVSPLGSIATRFLEEEELRSHHI--LERLD-AHIEELKRESEKTVRQ 536
M+L+ L+E + + L L E+E + + L L+ A I+EL+ E +TV+Q
Sbjct: 1032 MRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELE-ELRQTVKQ 1089
Score = 63.2 bits (152), Expect = 6e-10
Identities = 83/389 (21%), Positives = 160/389 (41%), Gaps = 44/389 (11%)
Query: 66 SQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREF 125
S L + H L ++ + + Q++ E K+ EEL K++ L+ + +R
Sbjct: 1344 STLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQ 1403
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
R + E+ L K+ E + + ++ Y +Q+S L+ LAE++ +
Sbjct: 1404 R--------ELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLG 1455
Query: 186 AQLVNRKQKLESVELSSQSE--IQHLSSKLERANDTICANELEIERLTMRVNDLV----G 239
+ +Q LE VEL E +Q L++ A + + E + + + G
Sbjct: 1456 ERANLGRQFLE-VELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEG 1514
Query: 240 TSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKA 299
+ VL+E+Q+ QEE+++L A ++ E E Q E+L +K+
Sbjct: 1515 AKVKVLEERQR--------------FQEERQKLTAQVEQLEVFQREQTKQVEELSKKLAD 1560
Query: 300 TNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLES 359
++ V+ +++ A + + Q + + +QLN L Q E L+
Sbjct: 1561 SDQASKVQ----QQKLKAVQAQGGESQQEAQRLQAQLN--ELQAQLSQKEQAAEHYKLQM 1614
Query: 360 VSATC-----KQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMK 414
A KQ +QEL E+ L++++ N E +AE ++L ++ Q A +
Sbjct: 1615 EKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEA----E 1670
Query: 415 MEISHLTQELHQRDITIASTKGSSSDMEK 443
HLT ++ + +A D+ K
Sbjct: 1671 QTCRHLTAQVRSLEAQVAHADQQLRDLGK 1699
Score = 60.1 bits (144), Expect = 5e-09
Identities = 89/382 (23%), Positives = 159/382 (41%), Gaps = 61/382 (15%)
Query: 9 QNRGHGGGF---LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLR 65
Q++ GG L + EL EL I + K +E E L E S
Sbjct: 1387 QSKQAAGGLRAELLRAQRELGEL-----IPLRQKVAEQERTAQQLRA-------EKASYA 1434
Query: 66 SQLDVTHKEVGMLHQQV----EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQ 121
QL + K G+L ++ E +Q + +E Q +K +EL ++ E +
Sbjct: 1435 EQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEV 1494
Query: 122 MREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQS 181
RE + + E+E +TAK E + K L+ E+QR +Q++ L AQ EQ
Sbjct: 1495 QREAQSTAR-------ELEVMTAKYEGAKVKVLE-ERQR--FQEERQKLTAQ----VEQL 1540
Query: 182 EIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDL---- 237
E+ Q + + ++L S + KL+ ++ E +RL ++N+L
Sbjct: 1541 EVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQL 1600
Query: 238 -------------VGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIH 284
+ + T ++Q+ ++L+E + LE LQ+E +EL+A E L H
Sbjct: 1601 SQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRA---EAERLGH 1657
Query: 285 EARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSED 344
E +Q+ L+ K +H +R E +A + Q DL + + E
Sbjct: 1658 E--LQQAGLKTKEAEQTCRHLTAQVRSLEAQVA---HADQQLRDLGKFQVATDALKSREP 1712
Query: 345 LLQAEVTCLEGSLESVSATCKQ 366
+ + L+ S++S+ +C++
Sbjct: 1713 QAKPQ---LDLSIDSLDLSCEE 1731
Score = 59.7 bits (143), Expect = 7e-09
Identities = 97/492 (19%), Positives = 212/492 (43%), Gaps = 58/492 (11%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLH 79
+ E+E ++L+K+ VA + +E + +++L +L+ + + +E+
Sbjct: 798 TAESECEQLVKE----VAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAK 853
Query: 80 QQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMR--EFRGNTKNHREDRS 137
++V E + + EL +LH L R+ +++Q+K++R + + +E +
Sbjct: 854 EKVAGIESHSELQISRQQNELAELHANLA---RALQQVQEKEVRAQKLADDLSTLQEKMA 910
Query: 138 EIERLTAKIEEFRQKSLDWEK--QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL 195
+ A++E +K+ + ++ R + ++ + + Q + L EQ Q + + L
Sbjct: 911 ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQG---RQFCSTQAAL 967
Query: 196 ESVELSSQ---SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
+++E ++ +E++ L + L + + ER R+ G + L ++
Sbjct: 968 QAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAAR 1027
Query: 253 EKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAV------ 306
+L +L AL E++ E QE L H ++ K QE K + A
Sbjct: 1028 AELEM--RLQNALNEQRVEFATL---QEALAHALTEKEGKDQELAKLRGLEAAQIKELEE 1082
Query: 307 --EAIRPREESLAEK-KYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVT------------ 351
+ ++ +E LA+K K + G G + T + L+AEV+
Sbjct: 1083 LRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQ 1142
Query: 352 --CLEGSLESVSAT-------CKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQG 402
LE SLE+ A+ + L +L EK +EL ++ + E+ + ++
Sbjct: 1143 ADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKV--- 1199
Query: 403 EQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEI 462
Q +S A + K +++ QE +++ I+S + S + +++ ++ E K ++ +
Sbjct: 1200 -QDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLE--KEGESKELKRLVM 1256
Query: 463 LDQLESLKLENR 474
+ +S KLE R
Sbjct: 1257 AESEKSQKLEER 1268
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 93.6 bits (231), Expect = 4e-19
Identities = 120/565 (21%), Positives = 246/565 (43%), Gaps = 63/565 (11%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSL---RSQLDVTHKEVG 76
+ EAEL L +++ V ++ EG + + E L+SL + Q+ +
Sbjct: 896 TAEAELSRLHREV-AQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANE 954
Query: 77 MLHQQVEEHEKIKQEMTMEYKQELKKLHEELC-------------------ILKRSYEKL 117
L +Q+EE ++ ++ E KQ++++L +L + +R E L
Sbjct: 955 ALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEAL 1014
Query: 118 QKK--------QMREFRGNTKNHREDRSEIERLTAKIEEFRQKS--LDWEKQRLIYQQQV 167
K Q+R G++ + I+ L A+++ L+ E Q +I
Sbjct: 1015 AAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQ 1074
Query: 168 SSLEAQRKALAEQSEIIQAQLVNRK-QKLESVELSSQSEIQHLSSKLERANDTICA---- 222
E++ K L + E+ +++ +K ++LE E++H KL + A
Sbjct: 1075 ELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREH 1134
Query: 223 NELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENL 282
N + L R DLV ++ V Q+KEE+ R+ + L++ALQ + K + S +
Sbjct: 1135 NSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQ 1194
Query: 283 IHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTS 342
+ A+++ + KA ++E ++E A++ + Q + D + Q+ S
Sbjct: 1195 VAAAKVEAGHNRRHFKAA----SLELSEVKKELQAKEHLVQKLQAEADDL--QIREGKHS 1248
Query: 343 EDLLQAEVTCLEGSLESVSATCKQLSQELMEK---YEELKRMEAHNNEYKAEIKKLKEQI 399
+++ Q + E + + KQL ++L ++ +E++ ++ ++ + EI+ LK+Q+
Sbjct: 1249 QEIAQFQAELAEARAQ-LQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQL 1307
Query: 400 LQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEH 459
EQ LEG++ + ++ EL ++ T+ + L+A++ + ++
Sbjct: 1308 DLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQKD----KFMLQAKVSELKNNM--- 1360
Query: 460 KEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPL--------GSIATRFLEEEELR 511
K +L Q + LKL+ R + K G S P +P+ S+ L
Sbjct: 1361 KTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLRPPPAV 1420
Query: 512 SHHILERLDAHIEELKRESEKTVRQ 536
S L+ L++ +++LK+E + RQ
Sbjct: 1421 SKEPLKNLNSCLQQLKQEMDSLQRQ 1445
Score = 82.0 bits (201), Expect = 1e-15
Identities = 126/599 (21%), Positives = 253/599 (42%), Gaps = 94/599 (15%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
E +L+ ++ + G L + E + +K+ K+E + + AL T L+ + +
Sbjct: 405 EEMLQVLKEKMRLEGQLEALSLEASQALKE--------KAELQAQLAALSTKLQAQVECS 456
Query: 62 KSLRSQLDVTHKEVGMLHQQVEEHEKIK---QEMTMEYKQELKKLHEELCILKRSYEKLQ 118
S + + D EV L Q + E+ Q M L + +L + + Y++L
Sbjct: 457 HSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLM 516
Query: 119 KK---QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRK 175
K R + R ++ L +++++ + + + Q ++SSL++ R+
Sbjct: 517 AKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQ 576
Query: 176 ------ALAEQSEI-IQAQLVN------------RKQKLESVELSSQ-SEIQHLSSK--- 212
ALA+++ + +Q ++ + KLE+V LS Q +E QH S K
Sbjct: 577 WYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKG 636
Query: 213 -LERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE--------EKLRESEKLLE 263
+ I A+ L+ E M++ + + T+++E Q+ E+L+
Sbjct: 637 RIAAQLQGIEADMLDQEAAFMQIQE----AKTMVEEDLQRRLEEFEGERERLQRMADSAA 692
Query: 264 ALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESL-AEKKYT 322
+L+++ ++K L ++ + +Q+E L + T TQ EA++ RE+SL A + +
Sbjct: 693 SLEQQLEQVKLTLLQRDQQLEA--LQQEHLDLMKQLTLTQ---EALQSREQSLDALQTHY 747
Query: 323 SQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSL---------------------ESVS 361
+ Q L + + + LLQ E LE +L E S
Sbjct: 748 DELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETS 807
Query: 362 ATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLT 421
T ++L +EL K +++ ++ K +++K+KEQ LQ K+ +
Sbjct: 808 ETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQ-----------QKVMVEAYR 856
Query: 422 QELHQRDITIASTKGSSSDME---KRLRAE-MQKAEDKAVEHKEILDQLESLKLENRHLS 477
++ +D I+ K + ++ K LR E MQ +K E+ + +H++
Sbjct: 857 RDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMA 916
Query: 478 EMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 536
++ L+ E + L S+ +F +E+ + E L IEEL++E+ K + +
Sbjct: 917 DLEGHLQSAQKERDEMETHLQSL--QFDKEQMVAVTEANEALKKQIEELQQEARKAITE 973
Score = 70.5 bits (171), Expect = 4e-12
Identities = 120/570 (21%), Positives = 233/570 (40%), Gaps = 80/570 (14%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIR---EQELKSLRSQLDVTHKEVGMLHQ 80
++QE ++ + + E+EG L+ EQ+L+ ++ L +++ L Q
Sbjct: 658 QIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQ 717
Query: 81 QVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHRED----- 135
EH + +++T+ ++ L+ + L L+ Y++LQ + + E +G + RED
Sbjct: 718 ---EHLDLMKQLTLT-QEALQSREQSLDALQTHYDELQAR-LGELQGEAAS-REDTICLL 771
Query: 136 -----------------RSEIERLTAKIEEFRQKSLDW-EKQR---LIYQQQVSSLEAQR 174
+ E++R ++EE +++ + EK R I QV L+ +
Sbjct: 772 QNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQET 831
Query: 175 KALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRV 234
AL +Q + I+ Q + +K +E+ + S+ Q L S+L+ +RL +
Sbjct: 832 AALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQ-LISELKATR----------KRLDSEL 880
Query: 235 NDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQ 294
+L M V E++ E +L + + +++ +L+ LQS + E + LQ
Sbjct: 881 KELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQ 940
Query: 295 -EKVKATNTQHAVEAIRPREESL---AEKKYTSQGQ------GDLDSVLSQLNFTHTSED 344
+K + A EA++ + E L A K T Q Q DL S ++ H + +
Sbjct: 941 FDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYE 1000
Query: 345 ----LLQAEVTCLEGSLESVSATCKQL------SQELMEKYEELKRMEAHNNEYKAEIKK 394
+L + + E+ A QL S + +E ++ +EA
Sbjct: 1001 NAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVSHSKTL 1060
Query: 395 LKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAED 454
L++++ + S LE + ++ L EL + S K+++ + +
Sbjct: 1061 LEKELQEVIALTSQELEESREKVLELEDELQE-----------SRGFRKKIKRLEESNKK 1109
Query: 455 KAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFL---EEEELR 511
A+E + +L L N L E LE L + + L L EEE+ +
Sbjct: 1110 LALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQ 1169
Query: 512 SHHILERLDAHIEELKRESEKTVRQFTALK 541
H+++ L A +E+ K + Q A K
Sbjct: 1170 MKHLVQALQASLEKEKEKVNSLKEQVAAAK 1199
Score = 62.0 bits (149), Expect = 1e-09
Identities = 94/420 (22%), Positives = 187/420 (44%), Gaps = 43/420 (10%)
Query: 121 QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDW--EKQRLIYQQQVSSLEAQRKALA 178
Q +E G ++ R+ L + E +++ L EK RL Q + SLEA + AL
Sbjct: 375 QGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQ-ALK 433
Query: 179 EQSEIIQAQLVNRKQKLES-VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDL 237
E++E+ QAQL KL++ VE S S Q L DT+ + ++ER + ++
Sbjct: 434 EKAEL-QAQLAALSTKLQAQVECSHSS--QQRQDSLSSEVDTLKQSCWDLERAMTDLQNM 490
Query: 238 VGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKV 297
+ L L+ +E+ + L + +++ ++ S++N +H+ R Q LQ +
Sbjct: 491 LEAKNASL---ASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQ- 546
Query: 298 KATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSL 357
++ ++ +L K S Q ++ S+ S + L Q L+G +
Sbjct: 547 --------LQQVQLERTTLTSKLKAS--QAEISSLQSVRQWYQQQLALAQEARVRLQGEM 596
Query: 358 ESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEI 417
+ Q+ Q M + L+ ++ N ++ + + + ++ + ++ L+G++ ++
Sbjct: 597 AHI-----QVGQ--MTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADM 649
Query: 418 SHLTQELHQRDITIASTKGSSSDMEKRL------RAEMQKAEDKAVEHKEILDQLESLKL 471
L QE I A T D+++RL R +Q+ D A ++ L+Q++ L
Sbjct: 650 --LDQEAAFMQIQEAKTM-VEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLL 706
Query: 472 ENRHLSEMVMKLELGL-HECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRES 530
+ E + + L L + +L L S R + L++H+ + L A + EL+ E+
Sbjct: 707 QRDQQLEALQQEHLDLMKQLTLTQEALQS---REQSLDALQTHY--DELQARLGELQGEA 761
Score = 55.8 bits (133), Expect = 1e-07
Identities = 63/287 (21%), Positives = 130/287 (45%), Gaps = 19/287 (6%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTH---ALETCLKIREQELKSLRSQLDVTHKE 74
L EA+L +L Q+ ++ K+ E H AL+ L+ ++++ SL+ Q+ E
Sbjct: 1142 LAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVE 1201
Query: 75 VGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ---KKQMREFRGNTKN 131
G H + H K E K+EL+ + L+ + LQ K +E
Sbjct: 1202 AG--HNR--RHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAE 1257
Query: 132 HREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNR 191
E R++++ L +++E K ++ + +V E + ++L +Q ++ + Q
Sbjct: 1258 LAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQ---G 1314
Query: 192 KQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
+++LE + Q +Q++ S+LE A + + + + L +V++L T+LQ+ QQ
Sbjct: 1315 RKELEGL----QQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQL 1370
Query: 252 EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK 298
+ LR + +E K E ++ + I + + L+E ++
Sbjct: 1371 KLDLRRG--AAKTRKEPKGEASSSNPATPIKIPDCPVPASLLEELLR 1415
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 93.2 bits (230), Expect = 5e-19
Identities = 127/568 (22%), Positives = 234/568 (41%), Gaps = 91/568 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQ--ELKS-----------LRSQL 68
E E EL +ID M ++ ++ + +++ TC + +Q E+K+ L Q
Sbjct: 1222 EKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQK 1281
Query: 69 DVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGN 128
+ G L +VEE E + ++T + KQ L + EEL K+QM E
Sbjct: 1282 ARLQTQNGELSHRVEEKESLISQLT-KSKQALTQQLEEL-----------KRQMEE---- 1325
Query: 129 TKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIY-QQQVSSLEAQRKALAEQSEIIQ-- 185
E + A + D + R Y ++Q + E QR SE+ Q
Sbjct: 1326 ---------ETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWR 1376
Query: 186 ----AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLV--- 238
+ R ++LE + +Q E AN + E +RL V DL+
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDL 1436
Query: 239 ---GTSMTVLQEQQQK--------EEKLRESEKLLEALQEEKRELKAALQSQENLIHEA- 286
T+ L ++Q+ ++KL ES+ LEA Q+E R L L N E
Sbjct: 1437 ERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVV 1496
Query: 287 ------RIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQL--NF 338
R + + LQE++ + T+ E + +E+ KK Q + DL L ++ +
Sbjct: 1497 DQLETLRRENKNLQEEI-SDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555
Query: 339 THTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRM--------EAHNNEYKA 390
H +L+ ++ +S +L ++++EK EE++++ EA + A
Sbjct: 1556 EHEESKILRVQL--------ELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDA 1607
Query: 391 EIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQ 450
EI+ + L+ ++ L M++++ H +++ + + + +G D + L ++
Sbjct: 1608 EIRS-RNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALR 1666
Query: 451 KAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPL--GSIATRFLEEE 508
ED E I+++ L LE L EM + LE L L S + L +
Sbjct: 1667 SNED-LKEQLAIVERRNGLLLE--ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQ 1723
Query: 509 ELRSHHILERLDAHIEELKRESEKTVRQ 536
+ ++L+A I + + E E ++++
Sbjct: 1724 NTSLINTKKKLEADIAQCQAEVENSIQE 1751
Score = 81.3 bits (199), Expect = 2e-15
Identities = 121/557 (21%), Positives = 236/557 (42%), Gaps = 84/557 (15%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQ---LDVTHKE 74
L + EL +++ + +++ + T LE + E+E K+ + L + +
Sbjct: 1284 LQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHD 1343
Query: 75 VGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHRE 134
+L +Q EE ++ K E+ ++ L K + E+ + YE ++ E K +
Sbjct: 1344 CDLLREQYEEEQEAKAEL----QRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1399
Query: 135 DRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQ--VSSLEAQRKALA---EQSEIIQAQLV 189
E E T + SL+ KQRL + + + LE A A ++ L
Sbjct: 1400 RLQEAEENTETANS-KCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLA 1458
Query: 190 NRKQKLESVEL---SSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQ 246
KQKL+ + ++Q E + LS++L + + ++E L +L + +
Sbjct: 1459 EWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTE 1518
Query: 247 EQQQKEEKLRESEKLLEALQEEKRELKAALQSQE-NLIHE----ARIQ------KEKLQE 295
+ + + L+E+EK + +++EK +L+ AL+ E +L HE R+Q K +L
Sbjct: 1519 QIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDR 1578
Query: 296 KV---------KATNTQHAVEA--------IRPREESLAEKKYTSQGQGDLDSVLSQLNF 338
KV N+Q A EA IR R ++L KK + +GDL+ + QL
Sbjct: 1579 KVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKK---KMEGDLNEMEIQLGH 1635
Query: 339 THTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQ 398
++ Q + ++G L+ + + E+L +E N E++++K
Sbjct: 1636 SNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVA 1695
Query: 399 ILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVE 458
+ Q E++ + E ++ S Q LH ++ ++ +TK K+L A++ + +
Sbjct: 1696 LEQTERTRRLS-EQELLDASDRVQLLHSQNTSLINTK-------KKLEADIAQCQ----- 1742
Query: 459 HKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILER 518
++E+ E+R+ E K +I + EEL+ +
Sbjct: 1743 -----AEVENSIQESRNAEEKAKK----------------AITDAAMMAEELKKE---QD 1778
Query: 519 LDAHIEELKRESEKTVR 535
AH+E +K+ E+TV+
Sbjct: 1779 TSAHLERMKKNLEQTVK 1795
Score = 76.6 bits (187), Expect = 5e-14
Identities = 107/528 (20%), Positives = 218/528 (41%), Gaps = 85/528 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E + +L ++++ ++ + E G T A K RE E + +R L+ +
Sbjct: 1137 EKQRSDLARELE-EISERLEEASGATSAQIEMNKKREAEFQKMRRDLE----------EA 1185
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+HE + + + +L E++ L+R +KL+K++ E + EI+
Sbjct: 1186 TLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEK-----------SELKMEIDD 1234
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELS 201
+ + IE + + E+ + Q S ++A+ + +Q+++I L +K +L
Sbjct: 1235 MASNIEALSKSKSNIERTCRTVEDQFSEIKAKDE---QQTQLIH-DLNMQKARL------ 1284
Query: 202 SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL 261
Q++ LS ++E I + LT ++ +L ++Q EE+ + +
Sbjct: 1285 -QTQNGELSHRVEEKESLISQLTKSKQALTQQLEEL----------KRQMEEETKAKNAM 1333
Query: 262 LEALQEEKRE---LKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAE 318
ALQ + + L+ + ++ E + K +V T++ +AI+ EE
Sbjct: 1334 AHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1393
Query: 319 KKYTSQ----GQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQE---- 370
KK +Q + + ++ S+ ++ LQ EV L LE C L ++
Sbjct: 1394 KKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNF 1453
Query: 371 ---LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSA---LEGMKMEISHLTQEL 424
L E ++L +A + E + L ++ + +Y LE ++ E +L +E+
Sbjct: 1454 DKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEI 1513
Query: 425 HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLE 484
IA T + + EK + Q+ D V +E+ LE H +++++
Sbjct: 1514 SDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLE-------HEESKILRVQ 1566
Query: 485 LGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEK 532
L L + + EL ++E+ D IE+LKR S++
Sbjct: 1567 LELSQV----------------KSEL-DRKVIEK-DEEIEQLKRNSQR 1596
Score = 75.1 bits (183), Expect = 2e-13
Identities = 93/487 (19%), Positives = 210/487 (43%), Gaps = 40/487 (8%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFR----------GNTKNH 132
E+ E+ K+E+ + K+L E++ L + LQ + E G K+
Sbjct: 858 EDFERTKEELARSEARR-KELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSK 916
Query: 133 REDRSEIERLTAKIEEFRQ-------KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
++++ LT ++EE + K + E + ++ + LE + ++ +
Sbjct: 917 ILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATE 976
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVL 245
++ N +++ ++E + + S E T+ ++L++E +VN L+ + +
Sbjct: 977 NKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTL--DDLQVEE--DKVNGLIKINAKLE 1032
Query: 246 QEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN---T 302
Q+ E L + +KL L+ KR+L+ L+ + I + K++++EK+K +
Sbjct: 1033 QQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELS 1092
Query: 303 QHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSA 362
Q + + SL +K + Q ++ + ++ HT ++ + + L LE +S
Sbjct: 1093 QLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISE 1152
Query: 363 TCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGE-------QSYSSALEGMKM 415
++ S + E K+ EA E++ + L+E LQ E + + ++ +
Sbjct: 1153 RLEEASGATSAQIEMNKKREA---EFQKMRRDLEEATLQHEATAATLRKKQADSVAELGE 1209
Query: 416 EISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRH 475
+I +L + + + + K DM + A + + + + DQ +K ++
Sbjct: 1210 QIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQ 1269
Query: 476 LSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSH--HILERLDAHIEELKRESEKT 533
++++ +L + + L G ++ R E+E L S + L +EELKR+ E+
Sbjct: 1270 QTQLIH--DLNMQKARLQTQN-GELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEE 1326
Query: 534 VRQFTAL 540
+ A+
Sbjct: 1327 TKAKNAM 1333
Score = 50.8 bits (120), Expect = 3e-06
Identities = 85/407 (20%), Positives = 166/407 (40%), Gaps = 62/407 (15%)
Query: 22 EAELQELMKQIDIMVAHKKSEWE----GRTHALETCLKIREQELKSLRSQL--------D 69
+ EL ++ ++D V K E E A E + + E++S L D
Sbjct: 1566 QLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGD 1625
Query: 70 VTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNT 129
+ E+ + H + E K T++ + + +LH + + RS E L K+Q+
Sbjct: 1626 LNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDAL--RSNEDL-KEQLAIVERRN 1682
Query: 130 KNHREDRSEIERLTAKIEEFR----QKSLDW-EKQRLIYQQQVSSLEAQRKALAEQSEII 184
E+ E++ + E R Q+ LD ++ +L++ Q S + ++K A+ ++
Sbjct: 1683 GLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQC- 1741
Query: 185 QAQLVNRKQKLESVELSSQSEIQH---LSSKLERANDTICANELEIERLTMRVNDLVGTS 241
QA++ N Q+ + E ++ I ++ +L++ DT +ER+ + V
Sbjct: 1742 QAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDT----SAHLERMKKNLEQTVKDL 1797
Query: 242 MTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
L E +Q L+ +K ++ L+ REL+ L ++ EA K + KV
Sbjct: 1798 QHRLDEAEQLA--LKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKV---- 1851
Query: 302 TQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVS 361
K+ T Q + D ++L + D LQA+V + E
Sbjct: 1852 -----------------KEMTYQAEEDHKNILRLQDLV----DKLQAKVKSYKRQAEEAE 1890
Query: 362 -------ATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQ 401
+ C+++ EL E E E+ N+ +A+ + + Q ++
Sbjct: 1891 EQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
Score = 49.7 bits (117), Expect = 7e-06
Identities = 79/432 (18%), Positives = 165/432 (38%), Gaps = 94/432 (21%)
Query: 192 KQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
K L+S E ++ E+ + ER + + +E + L ++ L+ + + Q +
Sbjct: 841 KPLLKSAE--AEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSE 898
Query: 252 EEKLRESEKLLEALQEEK-------RELKAALQSQENLIHEARIQKEKLQEK-------- 296
E L ++E+ E L + K +EL L+ +E + E +K L++K
Sbjct: 899 TENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDI 958
Query: 297 -------VKATNTQHAVE-----------AIRPREESLAEKKYT-----SQGQGDLDSVL 333
K +HA E A+ L ++K + Q DL
Sbjct: 959 DDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018
Query: 334 SQLNFTHTSEDLLQAEVTCLEGSLE----------------------------SVSATCK 365
++N L+ + LEGSLE + +
Sbjct: 1019 DKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQ 1078
Query: 366 QLSQELMEKYEELKRMEA-------HNNEYKAEIKKLK------EQILQGEQSYSSALEG 412
Q+ ++L +K EL +++A H+ +++ +IK+L+ E+ ++ E + + +E
Sbjct: 1079 QIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEK 1138
Query: 413 MKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK----AEDKAVEH--------K 460
+ +++ +E+ +R + + +M K+ AE QK E+ ++H K
Sbjct: 1139 QRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRK 1198
Query: 461 EILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLD 520
+ D + L + +L + KLE E + + + S L + + ++
Sbjct: 1199 KQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMAS-NIEALSKSKSNIERTCRTVE 1257
Query: 521 AHIEELKRESEK 532
E+K + E+
Sbjct: 1258 DQFSEIKAKDEQ 1269
Score = 43.1 bits (100), Expect = 6e-04
Identities = 42/195 (21%), Positives = 93/195 (47%), Gaps = 25/195 (12%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTH------- 72
+ E + ++ + +M K E + H LE K EQ +K L+ +LD
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAH-LERMKKNLEQTVKDLQHRLDEAEQLALKGG 1812
Query: 73 -KEVGMLHQQVEEHEKIKQEMTMEYK---QELKKLHEELCILKRSYEKLQKKQMREFRGN 128
K++ L +V E ++ E+ +E K + LK H+ YE+ K+ + +
Sbjct: 1813 KKQIQKLENRVRE---LENELDVEQKRGAEALKGAHK--------YERKVKEMTYQAEED 1861
Query: 129 TKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQL 188
KN + +++L AK++ +++++ + E+Q + ++ + + AE+++I ++Q+
Sbjct: 1862 HKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQV 1921
Query: 189 VNRKQKLESVELSSQ 203
K + +S ++ SQ
Sbjct: 1922 --NKLRAKSRDVGSQ 1934
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 92.0 bits (227), Expect = 1e-18
Identities = 130/550 (23%), Positives = 249/550 (45%), Gaps = 50/550 (9%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
+AELQ M + + VA ++++E T A++ ++ E + K L +L + V ++ +
Sbjct: 1358 KAELQRAMSKANSEVAQWRTKYE--TDAIQRTEELEEAK-KKLAQRLQDAEEHVEAVNAK 1414
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
EK KQ + + E++ L ++ + L KKQ R K E + + E
Sbjct: 1415 CASLEKTKQRL----QNEVEDLMIDVERTNAACAALDKKQ----RNFDKILAEWKQKCEE 1466
Query: 142 LTAKIE----EFRQKSLDWEKQRLIYQQ---QVSSLEAQRKALAEQSEIIQAQLVN---R 191
A++E E R S + K + Y++ Q+ +L+ + K L ++ + Q+ R
Sbjct: 1467 THAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKR 1526
Query: 192 KQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
+LE ++ + E L + LE A ++ E +I R+ + +N + + E+ ++
Sbjct: 1527 IHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1586
Query: 252 EEKLRESE-KLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN--TQHAVEA 308
++++ + +++E++Q L A ++S+ + I + + L E N + A EA
Sbjct: 1587 IDQMKRNHIRIVESMQST---LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEA 1643
Query: 309 IRPREESLAEKKYTSQGQGDL----DSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATC 364
+R + A K T D + + QL +LLQAE+ L +LE +
Sbjct: 1644 LRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSR 1703
Query: 365 KQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI--LQGE-----QSYSSALEGMKMEI 417
K QEL++ E ++ + N KKL+ I +QGE Q +A E K I
Sbjct: 1704 KIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAI 1763
Query: 418 SH---LTQELHQRDITIASTKGSSSDME---KRLRAEMQKAEDKAVE-HKEILDQLES-- 468
+ + +EL + T A + ++E K L+ + +AE A++ K+ + +LE+
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARV 1823
Query: 469 LKLENRHLSEMVMKLEL--GLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEEL 526
+LE SE +E GL + V L + T + LR ++++L A ++
Sbjct: 1824 RELEGEVESEQKRNVEAVKGLRKHERKVKEL-TYQTEEDRKNILRLQDLVDKLQAKVKSY 1882
Query: 527 KRESEKTVRQ 536
KR++E+ Q
Sbjct: 1883 KRQAEEAEEQ 1892
Score = 78.2 bits (191), Expect = 2e-14
Identities = 102/509 (20%), Positives = 213/509 (41%), Gaps = 92/509 (18%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E ++ LM++ + + ++E + A E C +L + QL+ KEV ++
Sbjct: 878 EEKMVTLMQEKNDLQLQVQAEADSLADAEERC-----DQLIKTKIQLEAKIKEVT---ER 929
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHRED 135
E+ E+I E+T + + KL +E LK+ + L+ +K+ KN E+
Sbjct: 930 AEDEEEINAELTAKKR----KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 985
Query: 136 RSEIERLTAKI-------EEFRQKSLD-----------WEKQRLIYQQQVSSLE------ 171
+ ++ AK+ +E Q++LD K ++ +QQV LE
Sbjct: 986 MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE 1045
Query: 172 ---------AQRKA-----LAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERAN 217
A+RK LA++S + + N KQ+L+ + E+ L SK+E
Sbjct: 1046 KKIRMDLERAKRKLEGDLKLAQESTM---DIENDKQQLDEKLKKKEFEMSGLQSKIEDEQ 1102
Query: 218 DTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQ 277
+ +I+ L R+ +L + + E++ + + LE + E E A
Sbjct: 1103 ALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1162
Query: 278 SQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPRE---ESLAE---------------K 319
+Q + + + +K++ ++ QH A R+ +S+AE +
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLE 1222
Query: 320 KYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELK 379
K S+ + ++D + S + ++ L+ LE L + ++ + + + +
Sbjct: 1223 KEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRA 1282
Query: 380 RMEAHNNEYKAEIKK---LKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKG 436
R++ + EY ++ + L Q+ +G+Q+++ +E +K + L +E+ + + +
Sbjct: 1283 RLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQ---LEEEIKAKSALAHALQS 1339
Query: 437 SSSDM---------EKRLRAEMQKAEDKA 456
S D E+ +AE+Q+A KA
Sbjct: 1340 SRHDCDLLREQYEEEQEAKAELQRAMSKA 1368
Score = 57.8 bits (138), Expect = 3e-08
Identities = 88/434 (20%), Positives = 175/434 (40%), Gaps = 87/434 (20%)
Query: 164 QQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICAN 223
+++++ EA+RK L E+ +V Q+ ++L Q+E L+ ER + I
Sbjct: 864 KEELAKTEAKRKELEEK-------MVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTK 916
Query: 224 ---ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQE 280
E +I+ +T R D E++ E + KL ++E ELK + E
Sbjct: 917 IQLEAKIKEVTERAED----------EEEINAELTAKKRKL----EDECSELKKDIDDLE 962
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAI-----RPREESLAEKKYTSQGQGDLDSVLSQ 335
+ A+++KEK + K N + + + +E A ++ Q DL + +
Sbjct: 963 LTL--AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDK 1020
Query: 336 LNFTHTSEDLLQAEVTCLEGSLE----------------------------SVSATCKQL 367
+N ++ L+ +V LEGSLE + +QL
Sbjct: 1021 VNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQL 1080
Query: 368 SQELMEKYEELK--------------RMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGM 413
++L +K E+ +++ E +A I++L+E+I + E++ + E
Sbjct: 1081 DEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEI-EAERASRAKAEKQ 1139
Query: 414 KMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK----AEDKAVEH--------KE 461
+ ++S +E+ +R + +M K+ AE QK E+ ++H K+
Sbjct: 1140 RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKK 1199
Query: 462 ILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDA 521
D + L + +L + KLE E + + L S + + + + L+
Sbjct: 1200 HADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS-NMETVSKAKGNLEKMCRALED 1258
Query: 522 HIEELKRESEKTVR 535
+ E+K + E+ R
Sbjct: 1259 QLSEIKTKEEEQQR 1272
Score = 42.4 bits (98), Expect = 0.001
Identities = 39/187 (20%), Positives = 91/187 (48%), Gaps = 3/187 (1%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHK-EVGML 78
+ E + ++ + +M K E + H LE K EQ +K L+ +LD + +
Sbjct: 1754 NAEEKAKKAITDAAMMAEELKKEQDTSAH-LERMKKNLEQTVKDLQHRLDEAEQLALKGG 1812
Query: 79 HQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSE 138
+Q+++ E +E+ E + E K+ E + L R +E+ K+ + + KN +
Sbjct: 1813 KKQIQKLEARVRELEGEVESEQKRNVEAVKGL-RKHERKVKELTYQTEEDRKNILRLQDL 1871
Query: 139 IERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
+++L AK++ +++++ + E+Q + + ++ + + E+++I ++Q+ + K V
Sbjct: 1872 VDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREV 1931
Query: 199 ELSSQSE 205
SE
Sbjct: 1932 HTKIISE 1938
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 91.7 bits (226), Expect = 2e-18
Identities = 104/511 (20%), Positives = 239/511 (46%), Gaps = 34/511 (6%)
Query: 25 LQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE 84
+++ + ++ + + KSE+E + + E+ K L+ QL V + +++++
Sbjct: 858 VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 85 HEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNT----KNHREDRSEIE 140
+ ++E + + K EL + E+L I ++ K +K+ ++ +GN ++ + + +IE
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQL-IQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIE 976
Query: 141 RLTA--KIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALA------EQSEIIQAQLVNRK 192
L KI ++ L+ + Q+ + Q L A+++ ++ E+S+ QL +
Sbjct: 977 ALQGELKIAVLQKTELENKLQQQL-TQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF 1035
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
ES L+++ +++ + KL A + + +N +I + +L T+ Q+ +KE
Sbjct: 1036 YGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKE 1095
Query: 253 EKLRESEKLLEALQEEKRELKAALQSQENL---IHEARIQKEKLQEKVKATNTQHAVEAI 309
++L+E K L+ +Q+EK + L ++++ I E + ++EK K+ H +E+I
Sbjct: 1096 QQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESI 1155
Query: 310 ------RPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSL--ESVS 361
+ ++ L ++K QG+ DS+ + + ++ +L+ +V E L E +
Sbjct: 1156 KEITNLKDAKQLLIQQKLELQGKA--DSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIE 1213
Query: 362 ATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLT 421
K L E+ EK +K+ E + + +I L E + ++ + S+ + E+ T
Sbjct: 1214 KEAK-LHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVS-ELEKQT 1271
Query: 422 QELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVM 481
+L + +T ++ D + L K E + + Q + L+L+ + +
Sbjct: 1272 DDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL-----QTKVLELQRKLDNTTAA 1326
Query: 482 KLELGLHECSLPVSPLGSIATRFLEEEELRS 512
ELG SL + ++ ++ E+ E+++
Sbjct: 1327 VQELGRENQSLQIKHTQALNRKWAEDNEVQN 1357
Score = 89.0 bits (219), Expect = 1e-17
Identities = 124/576 (21%), Positives = 247/576 (42%), Gaps = 93/576 (16%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQI--DIMVAHKKSEW--EGRTHALETCLKIR 57
EA+ + + GHGG + + + L++Q D+ + K+ +W E LE ++
Sbjct: 61 EAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ 120
Query: 58 EQELKSLRSQLDVTHKEVGMLHQQVEEHE----KIKQEMTMEYKQELKKLHEELCILKRS 113
+QE K D + E+ L QQ+EE + IKQ + ++Q+ +L E+ +K
Sbjct: 121 QQEAKPDGLVTD-SSAELQSLEQQLEEAQTENFNIKQMKDL-FEQKAAQLATEIADIKSK 178
Query: 114 YEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQ 173
Y+ +++ +RE ++ RLT ++ + D K L+ + + +
Sbjct: 179 YD--EERSLREAA---------EQKVTRLTEELNKEATVIQDL-KTELLQRPGIEDVAVL 226
Query: 174 RKALAEQSEIIQAQLVNRKQ----------KLESVELSSQSEIQHLSSKLERANDTICAN 223
+K L + ++ + R++ KL+S SS++ I L S+L + +
Sbjct: 227 KKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286
Query: 224 ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLI 283
E+++L VN+L Q+ Q E L + E+ L+E+ E + ++ + +
Sbjct: 287 VQELQKLKSSVNELT-------QKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATL 339
Query: 284 HEARIQKEKLQEKVKATNTQ-HAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTS 342
H+ + ++LQ ++ A+ T H + L+EK +Q + +L+ T
Sbjct: 340 HQKDLDCQQLQSRLSASETSLHRIHV------ELSEKGEATQ------KLKEELSEVETK 387
Query: 343 EDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLK----EQ 398
L+AE L+ E QL E+ + + +L E E +K+ + E+
Sbjct: 388 YQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEK 447
Query: 399 ILQGEQ-------SYSSALEGMKMEISHLTQELHQRD--------------ITIASTKGS 437
++ EQ S E +K ++++ T+ HQ D T A + +
Sbjct: 448 LMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREA 507
Query: 438 SSDMEKRLRAEMQKAEDKAVEHKEILDQ--LESLKLENRHLSEMVMKLELGLHECSLPVS 495
+D+E+ LR K D+ +++ E L Q E++ L + ++ K++ G E
Sbjct: 508 QNDLEQVLRQIGDK--DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGE------ 559
Query: 496 PLGSIATRFLEEEELRSHHILERLDAHIEELKRESE 531
T L + + ++H + E++ E+LK +SE
Sbjct: 560 ------TAVLNQLQEKNHTLQEQVTQLTEKLKNQSE 589
Score = 84.0 bits (206), Expect = 3e-16
Identities = 124/591 (20%), Positives = 252/591 (42%), Gaps = 92/591 (15%)
Query: 27 ELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHE 86
EL+ + ++++ + + L+ ++QEL + +QLD +V Q +EH
Sbjct: 649 ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLD----QVTAKLQDKQEHC 704
Query: 87 KIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI 146
+ EYK++ L ++ L+ +KL+ + E + + + +D + +L +
Sbjct: 705 SQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSL-EVKASKEQALQDLQQQRQLNTDL 763
Query: 147 E---EFRQKSLDWEKQ-----RLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
E K L+ EK+ RL Q++ +LE+ ++ L +Q E + Q++ KQ E+
Sbjct: 764 ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEE--EKQIL--KQDFET- 818
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTM-----------------RVNDLVGTS 241
LS +++IQH E N+ I E++++ M +V+D + S
Sbjct: 819 -LSQETKIQH-----EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS 872
Query: 242 MTVLQEQQQK--------EEKLRESEKLLEALQE----EKRELKAALQSQENLIHEARIQ 289
+ +++ QK E+ +E + L+ E E++ELK +L+ ++ H+ +++
Sbjct: 873 KSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE 932
Query: 290 KEKLQEK-VKATNTQHAVEAIRP---------REESLAEKKYTSQGQGDLD-SVLS---- 334
+QE+ ++A NT E ++ S +KK QG+L +VL
Sbjct: 933 LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992
Query: 335 ----QLNFTHTSEDLL--QAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEY 388
Q T +++L + +++ L+ + E T KQL + + EL
Sbjct: 993 ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 389 KAEIKKLKEQILQGE----------QSYSSALEGMKMEISHLTQELHQRDITIASTKGSS 438
+ ++ +E ++ Q +A ++ + + Q+L +R + +
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1112
Query: 439 SDMEKRLRAEMQK----AEDKAVEHKEIL---DQLESLKLENRHLSEMVMKLELGLHECS 491
S EK L E K E K + KEI ++L+S KLE+ + + L +
Sbjct: 1113 SLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQK 1172
Query: 492 LPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRE-SEKTVRQFTALK 541
L + +E+E+ + +++ EELK+E EK + + +K
Sbjct: 1173 LELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIK 1223
Score = 79.7 bits (195), Expect = 6e-15
Identities = 109/536 (20%), Positives = 227/536 (42%), Gaps = 55/536 (10%)
Query: 27 ELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHE 86
EL Q+D K+ E + T K+RE + + L+ +++G Q+++ E
Sbjct: 478 ELQHQLD---KTKQQHQEQQALQQSTTAKLREAQ-----NDLEQVLRQIGDKDQKIQNLE 529
Query: 87 KIKQEMTMEYKQELKKLHEEL-----------CILKRSYEKLQ--KKQMREFRGNTKNHR 133
+ Q+ + E L+K E+L +L + EK ++Q+ + KN
Sbjct: 530 ALLQK-SKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQS 588
Query: 134 EDRSEI-ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK 192
E + E L +++E + + + L + V+ L +Q E+ + Q+ +
Sbjct: 589 ESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKT 648
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE 252
+ L S E + ++ L + L+ A + + + E+ ++T +++ + + Q E
Sbjct: 649 ELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLE 708
Query: 253 EKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEK-LQ--EKVKATNTQHAVEAI 309
L+E ++ +L+++ EL+ ++ E E + KE+ LQ ++ + NT + A
Sbjct: 709 SHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRAT 768
Query: 310 RPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQ 369
++ EK+ S + DL L + E L+ E++S K +
Sbjct: 769 ELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHE 828
Query: 370 ELMEKYE----ELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELH 425
EL + + EL++++ E+ +K+++ S + +K S +E
Sbjct: 829 ELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL-------SKVSDSLKNSKSEFEKENQ 881
Query: 426 QRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLEL 485
+ I + + +++ +L+ +M E+ E KE+ LE K + L KLEL
Sbjct: 882 KGKAAILDLEKTCKELKHQLQVQM---ENTLKEQKELKKSLEKEKEASHQL-----KLEL 933
Query: 486 GLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK 541
+ L + ++ EE++L+ +I ELK+ SE+ +Q AL+
Sbjct: 934 NSMQEQL-IQAQNTLKQNEKEEQQLQ---------GNINELKQSSEQKKKQIEALQ 979
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 91.7 bits (226), Expect = 2e-18
Identities = 127/547 (23%), Positives = 242/547 (44%), Gaps = 44/547 (8%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
+AELQ M + + VA ++++E T A++ ++ E + K L +L + V ++ +
Sbjct: 1358 KAELQRGMSKANSEVAQWRTKYE--TDAIQRTEELEEAK-KKLAQRLQDAEEHVEAVNSK 1414
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEE--LCILKRSYEKLQKKQMREFRGNTKNHREDRSEI 139
EK KQ + E + + + CI ++ K + E++ + + E ++E+
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWK---QKYEETQAEL 1471
Query: 140 ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEA---QRKALAEQSEIIQAQLVNRKQ--- 193
E A +E R S + K + Y++ + LE + K L ++ + Q+ +
Sbjct: 1472 E---ASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIH 1528
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
+LE V+ E L + LE A ++ E +I R+ + +N + + E+ ++ +
Sbjct: 1529 ELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELD 1588
Query: 254 KLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN--TQHAVEAIRP 311
+L+ + L ++ + L A ++S+ + + + + L E N + A EA+R
Sbjct: 1589 QLKRNH--LRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRN 1646
Query: 312 REESLAEKKYTSQGQGDL----DSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQL 367
+ K T D D + QL +L+QAEV L SLE K
Sbjct: 1647 LRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMA 1706
Query: 368 SQELMEKYEELKRMEAHNNEYKAEIKKLKEQI--LQGE-----QSYSSALEGMKMEISH- 419
QEL++ E ++ + N KKL+ I +QGE Q +A E K I+
Sbjct: 1707 EQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDA 1766
Query: 420 --LTQELHQRDITIASTKGSSSDME---KRLRAEMQKAEDKAVE-HKEILDQLES--LKL 471
+ +EL + T A + +ME K L+ + +AE A++ K+ + +LE+ +L
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL 1826
Query: 472 ENRHLSEMVMKLEL--GLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRE 529
E+ SE +E GL + V L + T + LR ++++L ++ KR+
Sbjct: 1827 ESEVESEQKHNVEAVKGLRKHERRVKEL-TYQTEEDRKNILRLQDLVDKLQTKVKAYKRQ 1885
Query: 530 SEKTVRQ 536
+E+ Q
Sbjct: 1886 AEEAEEQ 1892
Score = 73.6 bits (179), Expect = 4e-13
Identities = 109/527 (20%), Positives = 220/527 (41%), Gaps = 58/527 (11%)
Query: 44 EGRTHALETCLKIREQELKSLRSQLDVTHK---EVGMLHQQVEEHEKIKQEMTMEYKQEL 100
E + + L EQ++ L L+ K ++ +++E K+ QE TM+ + +
Sbjct: 1018 EDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDK 1077
Query: 101 KKLHEELCILKRSYE------KLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSL 154
++L+E+L K+ +E K++ +Q + K +E ++ IE L +IE R
Sbjct: 1078 QQLNEKL--KKKEFEMSNLQGKIEDEQALAIQLQ-KKIKELQARIEELEEEIEAERASRA 1134
Query: 155 DWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQL-VNRKQKLESVELS---SQSEIQH-- 208
EKQR ++ LE + L E AQ+ +N+K++ E ++ +S +QH
Sbjct: 1135 KAEKQRSDLSRE---LEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEA 1191
Query: 209 ---------------LSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
L +++ E E L M +NDL TV + +
Sbjct: 1192 TAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKAN--- 1248
Query: 254 KLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPRE 313
EK+ L+++ E+K + Q+ LI+E QK +L + + E R +
Sbjct: 1249 ----FEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTE--------SGEFSRQLD 1296
Query: 314 ESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELME 373
E A S+G+ + +L E+ +A+ T L +L+S C L ++ E
Sbjct: 1297 EKDAMVSQLSRGKQAFTQQIEELK--RQLEEETKAKST-LAHALQSARHDCDLLREQYEE 1353
Query: 374 KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAS 433
+ E ++ ++ +E+ + + + + LE K +++ Q+ + + S
Sbjct: 1354 EQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNS 1413
Query: 434 TKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLP 493
S ++RL+ E+ ED ++ + +L + R+ +++ + + E
Sbjct: 1414 KCASLEKTKQRLQNEV---EDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAE 1470
Query: 494 VSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTAL 540
+ +R L E + + E H+E LKRE++ ++ + L
Sbjct: 1471 LEA-SQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDL 1516
Score = 70.5 bits (171), Expect = 4e-12
Identities = 103/506 (20%), Positives = 203/506 (40%), Gaps = 86/506 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E ++ LM++ + + ++E + A E C +L + QL+ KEV ++
Sbjct: 878 EEKMVTLMQEKNDLQLQVQAEADALADAEERC-----DQLIKTKIQLEAKIKEVT---ER 929
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHRED 135
E+ E+I E+T + + KL +E LK+ + L+ +K+ KN E+
Sbjct: 930 AEDEEEINAELTAKKR----KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 985
Query: 136 RSEIERLTAKI-------EEFRQKSLD-----------WEKQRLIYQQQVSSLEA---QR 174
+ ++ AK+ +E Q++LD K + +QQV LE Q
Sbjct: 986 MAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQE 1045
Query: 175 KALAEQSEIIQAQLV--------------NRKQKLESVELSSQSEIQHLSSKLERANDTI 220
K L E + +L N KQ+L + E+ +L K+E
Sbjct: 1046 KKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALA 1105
Query: 221 CANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQE 280
+ +I+ L R+ +L + + E++ + + LE + E E A +Q
Sbjct: 1106 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1165
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTH 340
+ + + +K++ ++ + QH A R++ + L V +L
Sbjct: 1166 EMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKL---E 1222
Query: 341 TSEDLLQAEVTCLEGSLESVSAT-------CKQLSQELME---KYEELKRMEAHNNEYKA 390
+ L+ E+ L ++E+VS C+ L +L E K EE +R+ + KA
Sbjct: 1223 KEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKA 1282
Query: 391 EI--------KKLKE------QILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKG 436
+ ++L E Q+ +G+Q+++ +E +K ++ T+ + S +
Sbjct: 1283 RLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARH 1342
Query: 437 SSS------DMEKRLRAEMQKAEDKA 456
+ E+ +AE+Q+ KA
Sbjct: 1343 DCDLLREQYEEEQEAKAELQRGMSKA 1368
Score = 62.4 bits (150), Expect = 1e-09
Identities = 90/439 (20%), Positives = 176/439 (40%), Gaps = 87/439 (19%)
Query: 164 QQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICAN 223
+++++ EA+RK L E+ +V Q+ ++L Q+E L+ ER + I
Sbjct: 864 KEELAKTEAKRKELEEK-------MVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTK 916
Query: 224 ---ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQE 280
E +I+ +T R D E++ E + KL ++E ELK + E
Sbjct: 917 IQLEAKIKEVTERAED----------EEEINAELTAKKRKL----EDECSELKKDIDDLE 962
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAI-----RPREESLAEKKYTSQGQGDLDSVLSQ 335
+ A+++KEK + K N + + + +E A ++ Q DL +
Sbjct: 963 LTL--AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDK 1020
Query: 336 LNFTHTSEDLLQAEVTCLEGSLESVSATC----------------------------KQL 367
+N ++ L+ +V LEGSLE C +QL
Sbjct: 1021 VNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQL 1080
Query: 368 SQELMEKYEELK--------------RMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGM 413
+++L +K E+ +++ E +A I++L+E+I + E++ + E
Sbjct: 1081 NEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEI-EAERASRAKAEKQ 1139
Query: 414 KMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK----AEDKAVEH--------KE 461
+ ++S +E+ +R + +M K+ AE QK E+ ++H K+
Sbjct: 1140 RSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKK 1199
Query: 462 ILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDA 521
D + L + L + KLE E + ++ L S + + + + L+
Sbjct: 1200 HADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLAS-NMETVSKAKANFEKMCRTLED 1258
Query: 522 HIEELKRESEKTVRQFTAL 540
+ E+K + E+ R L
Sbjct: 1259 QLSEIKTKEEEQQRLINEL 1277
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 91.3 bits (225), Expect = 2e-18
Identities = 131/528 (24%), Positives = 246/528 (46%), Gaps = 80/528 (15%)
Query: 41 SEWEGRTHALETCLKIREQELKS-----------LRSQLDVTHKEVGMLHQQVEEHEKIK 89
S ++ R H +E K R +ELK L QL+ T LH+ +E+ ++K
Sbjct: 330 SRYKERLHDIEF-YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK 388
Query: 90 ---QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI 146
+M ME + KK+ EEL + E QK+ M E + + + +I R T+++
Sbjct: 389 AKLHDMEMERDMDRKKI-EELMEENMTLEMAQKQSMDE----SLHLGWELEQISR-TSEL 442
Query: 147 EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
E QKSL E L ++ LE + ++L + E ++ + + + + L + E
Sbjct: 443 SEAPQKSLGHEVNELT-SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI-LKMEKEN 500
Query: 207 QHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE---EKLRE-SEKLL 262
Q LS K+E I NE+ E+ +++ + S +++E+ Q E E LRE SE+ +
Sbjct: 501 QRLSKKVE-----ILENEIVQEKQSLQ--NCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 263 EALQEEKRELK---AALQSQENLIHEAR---IQKEK--LQEKVKATNTQHAVEAIRPREE 314
+ L++E L ++L+ + + EAR I+KE L E +K T+++ + R+
Sbjct: 554 KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
Query: 315 SLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEK 374
+ Y +G+ + + ++L+ +LLQ ++T ++ TC
Sbjct: 614 KKELEHYKEKGE-RAEELENELHHLEKENELLQKKIT-------NLKITC---------- 655
Query: 375 YEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAST 434
E+++ +E N+E + E +KLK + L ++ + LE ++ E S L +E + + S
Sbjct: 656 -EKIEALEQENSELERENRKLK-KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 435 KGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPV 494
K +S M A++Q +E+KE+ + E LK L K E L V
Sbjct: 714 KCASMKM-----AQLQ------LENKELESEKEQLKKGLELLKASFKKTE------RLEV 756
Query: 495 SPLG-SIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK 541
S G I + L++ S+ +++L++ +++L+ E++ + LK
Sbjct: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
Score = 79.7 bits (195), Expect = 6e-15
Identities = 102/474 (21%), Positives = 220/474 (46%), Gaps = 65/474 (13%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKS-LRSQLDVTHKEVGMLHQQV 82
+L++L +++ + +K+ ++ K+ E +L+S L+ L++ +++ L ++
Sbjct: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARL 983
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMRE--FRGNTKNHREDRS--- 137
EE + Y Q+L+ +EL +K++YE L+++Q E + + ED
Sbjct: 984 EE--------STNYNQQLR---QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1032
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLES 197
E + T ++ + + + ++ E+ Q + +L+ Q K L Q+ +QAQ++ +++ S
Sbjct: 1033 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1092
Query: 198 VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRE 257
++ + +Q ++KL+ N T+ + + M N + + L+ + + K RE
Sbjct: 1093 LQ-EQNTTLQTQNAKLQVENSTLNSQSTSL----MNQNAQLLIQQSSLENENESVIKERE 1147
Query: 258 SEK-LLEALQEEKRELKAALQSQENLIHEARIQK-EKLQEKVKATNTQHAVEAIRPRE-E 314
K L ++L ++ +L+ L+HE + + E L K + H + R+ E
Sbjct: 1148 DLKSLYDSLIKDHEKLE--------LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLE 1199
Query: 315 SLAEKKYTSQGQ-GDLDSVLS----QLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQ 369
+ +GQ DL+ +L ++ + + + + AE L G + ++ T QL +
Sbjct: 1200 DRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1259
Query: 370 ELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDI 429
E + K +++ N K E +L+ E S L ++ Q DI
Sbjct: 1260 ETEVLQTDHKNLKSLLNNSKLEQTRLEA------------------EFSKLKEQYQQLDI 1301
Query: 430 TIASTK-GSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMK 482
T STK + ++ +L+ +++ E++ +LDQ+++L L+NR L E M+
Sbjct: 1302 T--STKLNNQCELLSQLKGNLEE------ENRHLLDQIQTLMLQNRTLLEQNME 1347
Score = 77.8 bits (190), Expect = 2e-14
Identities = 115/539 (21%), Positives = 224/539 (41%), Gaps = 50/539 (9%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
EL+++ + ++ A +KS + L E E +SL ++ V +
Sbjct: 432 ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS 491
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQK--KQMREFRGNTKNHREDRSEIER 141
+ K+++E ++++ L E+ K+S + Q K + + + + E E
Sbjct: 492 KILKMEKE-NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELS 201
KI E + L+ L + Q+S+ EA+ K + ++++I+ + KL +E
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISA-EARVKDIEKENKILHESIKETSSKLSKIEFE 609
Query: 202 SQS---EIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRES 258
+ E++H K ERA + E E+ L + N+L+ +T L+ +K E L +
Sbjct: 610 KRQIKKELEHYKEKGERAEEL----ENELHHLE-KENELLQKKITNLKITCEKIEALEQE 664
Query: 259 EKLLEALQEEKRELKAALQSQENLIHEAR-IQKEKLQEKVKATNTQHAVEAIR------- 310
LE E R+LK L S +NL + ++KE Q + + VE+++
Sbjct: 665 NSELE---RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMA 721
Query: 311 ----PREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQ 366
+E +EK+ +G L + + S L E L+ +LE+ + +Q
Sbjct: 722 QLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ 781
Query: 367 LSQELME----------KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKME 416
L EL + EELK + + E K L+++ Q E+ ++ E
Sbjct: 782 LESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ----LEKE 837
Query: 417 ISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHL 476
L Q+ +D T+ ++EK E + + +KE +L+ L+ EN+
Sbjct: 838 NKRLRQQAEIKDTTLEENNVKIGNLEK----ENKTLSKEIGIYKESCVRLKELEKENK-- 891
Query: 477 SEMVMKLELGLHECSLPVSPLGS--IATRFLEEEELRSHHILERLDAHIEELKRESEKT 533
E+V + + + L S + T+ + + + H LE++ + E L + + T
Sbjct: 892 -ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST 949
Score = 75.5 bits (184), Expect = 1e-13
Identities = 121/506 (23%), Positives = 209/506 (41%), Gaps = 74/506 (14%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E E Q L K ++ + K R LE K EQE L KE
Sbjct: 786 LQDLEMENQTLQKNLEELKISSK-----RLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHRE 134
L QQ E + +E ++ ++E K L +E+ I K S +L++ + +E
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE-----------KE 889
Query: 135 DRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQK 194
++ ++R T I+ D ++L QQ + LE L + E I +N+++
Sbjct: 890 NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK----LTHELEKIG---LNKERL 942
Query: 195 LESVELSSQSEIQHLSSKLERA--------NDTICANELEIERLTMRVNDLVGTSMTVLQ 246
L + + S + L SKLE + I A E +E T L TV +
Sbjct: 943 LHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1002
Query: 247 -----EQQQKEEKLRESE--------KLLEALQEEKRELKAALQSQENLIHEAR------ 287
+Q+Q EE++ +S K QE REL L+ ++ LI R
Sbjct: 1003 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTREL---LKVKDRLIEVERNNATLQ 1059
Query: 288 IQKEKLQEKVKATNTQH-----AVEAIRPREESLAEKKYTSQGQG-DLDSVLSQLNFTHT 341
+K+ L+ ++K TQ+ + A++ + SL E+ T Q Q L S LN T
Sbjct: 1060 AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQST 1119
Query: 342 SEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEEL----KRMEAHNNEYKAEIKKLKE 397
S A++ + SLE+ + + + ++L Y+ L +++E + +E E
Sbjct: 1120 SLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEY----E 1175
Query: 398 QILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAV 457
++ + SA + +++E L +Q + KG D+EK L+ E +K +
Sbjct: 1176 SLISKHGTLKSAHKNLEVEHRDLEDRYNQ----LLKQKGQLEDLEKMLKVEQEKMLLENK 1231
Query: 458 EHKEILDQLESLKLENRHLSEMVMKL 483
H+ + + + L EN L+ +L
Sbjct: 1232 NHETVAAEYKKLCGENDRLNHTYSQL 1257
Score = 62.8 bits (151), Expect = 8e-10
Identities = 100/489 (20%), Positives = 205/489 (41%), Gaps = 32/489 (6%)
Query: 69 DVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEE---LCILKRSYEKLQKKQMREF 125
D++ +++ L + + H K + E+ + + +L EE L L + Q
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
T++ + E+ AKI RQ+ + +Q L +Q++ +E + K L +++ +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVL 245
+ R ++ EL + E KLE +IE RV +L + +L
Sbjct: 300 SDA--RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 246 QEQQQKEEKLR----ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
+ + E++L S+KL E L++E +LKA L E E + ++K++E ++
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHE-LEKENLQLKAKLHDME---MERDMDRKKIEELMEENM 413
Query: 302 TQHAVEAIRPREESLAEKKYTSQGQGDLD-SVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
T + + +ESL Q + S Q + H +L + + LE +S+
Sbjct: 414 TLEMAQK-QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Query: 361 SATCKQLS---QELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEI 417
+ T ++L + ++ +ME N +++ L+ +I+Q +QS L+ +
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS----LQNCQNLS 528
Query: 418 SHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD-----QLESLKLE 472
L +E Q + TI + + +S K L E + ++ +++ ++ E
Sbjct: 529 KDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKE 588
Query: 473 NRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEK 532
N+ L E + + L + + + E+ E E L+ + L++E+E
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER-----AEELENELHHLEKENEL 643
Query: 533 TVRQFTALK 541
++ T LK
Sbjct: 644 LQKKITNLK 652
Score = 48.9 bits (115), Expect = 1e-05
Identities = 57/251 (22%), Positives = 115/251 (45%), Gaps = 17/251 (6%)
Query: 51 ETCLKIREQELKSLRSQLDVTHKEVGMLHQ-QVEEHEKIKQEMTMEYKQELKKLHEELCI 109
E+ +K RE +LKSL L H+++ +LH+ Q E+E + + LK H+ L +
Sbjct: 1140 ESVIKERE-DLKSLYDSLIKDHEKLELLHERQASEYESL-----ISKHGTLKSAHKNLEV 1193
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSS 169
R E + +++ +G ++ E ++E+ +E +++ E ++L +
Sbjct: 1194 EHRDLEDRYNQLLKQ-KGQLED-LEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND--R 1249
Query: 170 LEAQRKALAEQSEIIQAQLVNRKQKLESVELSS---QSEIQHLSSKLERANDTICANELE 226
L L +++E++Q N K L + +L ++E L + ++ + T +
Sbjct: 1250 LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQ 1309
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEA 286
E L+ +L + +L + Q + ++ LLE E K + + ++E
Sbjct: 1310 CELLSQLKGNLEEENRHLLDQIQTL---MLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1366
Query: 287 RIQKEKLQEKV 297
R QKEKL+EK+
Sbjct: 1367 RRQKEKLEEKI 1377
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 91.3 bits (225), Expect = 2e-18
Identities = 131/528 (24%), Positives = 246/528 (46%), Gaps = 80/528 (15%)
Query: 41 SEWEGRTHALETCLKIREQELKS-----------LRSQLDVTHKEVGMLHQQVEEHEKIK 89
S ++ R H +E K R +ELK L QL+ T LH+ +E+ ++K
Sbjct: 330 SRYKERLHDIEF-YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLK 388
Query: 90 ---QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKI 146
+M ME + KK+ EEL + E QK+ M E + + + +I R T+++
Sbjct: 389 AKLHDMEMERDMDRKKI-EELMEENMTLEMAQKQSMDE----SLHLGWELEQISR-TSEL 442
Query: 147 EEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
E QKSL E L ++ LE + ++L + E ++ + + + + L + E
Sbjct: 443 SEAPQKSLGHEVNELT-SSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKI-LKMEKEN 500
Query: 207 QHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKE---EKLRE-SEKLL 262
Q LS K+E I NE+ E+ +++ + S +++E+ Q E E LRE SE+ +
Sbjct: 501 QRLSKKVE-----ILENEIVQEKQSLQ--NCQNLSKDLMKEKAQLEKTIETLRENSERQI 553
Query: 263 EALQEEKRELK---AALQSQENLIHEAR---IQKEK--LQEKVKATNTQHAVEAIRPREE 314
+ L++E L ++L+ + + EAR I+KE L E +K T+++ + R+
Sbjct: 554 KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
Query: 315 SLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEK 374
+ Y +G+ + + ++L+ +LLQ ++T ++ TC
Sbjct: 614 KKELEHYKEKGE-RAEELENELHHLEKENELLQKKIT-------NLKITC---------- 655
Query: 375 YEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIAST 434
E+++ +E N+E + E +KLK + L ++ + LE ++ E S L +E + + S
Sbjct: 656 -EKIEALEQENSELERENRKLK-KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
Query: 435 KGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPV 494
K +S M A++Q +E+KE+ + E LK L K E L V
Sbjct: 714 KCASMKM-----AQLQ------LENKELESEKEQLKKGLELLKASFKKTE------RLEV 756
Query: 495 SPLG-SIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALK 541
S G I + L++ S+ +++L++ +++L+ E++ + LK
Sbjct: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
Score = 78.6 bits (192), Expect = 1e-14
Identities = 116/547 (21%), Positives = 228/547 (41%), Gaps = 50/547 (9%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
EL+++ + ++ A +KS + L E E +SL ++ V +
Sbjct: 432 ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS 491
Query: 84 EHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQK--KQMREFRGNTKNHREDRSEIER 141
+ K+++E ++++ L E+ K+S + Q K + + + + E E
Sbjct: 492 KILKMEKE-NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELS 201
KI E + L+ L + Q+S+ EA+ K + ++++I+ + KL +E
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISA-EARVKDIEKENKILHESIKETSSKLSKIEFE 609
Query: 202 SQS---EIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRES 258
+ E++H K ERA + E E+ L + N+L+ +T L+ +K E L +
Sbjct: 610 KRQIKKELEHYKEKGERAEEL----ENELHHLE-KENELLQKKITNLKITCEKIEALEQE 664
Query: 259 EKLLEALQEEKRELKAALQSQENLIHEAR-IQKEKLQEKVKATNTQHAVEAIR------- 310
LE E R+LK L S +NL + ++KE Q + + VE+++
Sbjct: 665 NSELE---RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMA 721
Query: 311 ----PREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQ 366
+E +EK+ +G L + + S L E L+ +LE+ + +Q
Sbjct: 722 QLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ 781
Query: 367 LSQELME----------KYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKME 416
L EL + EELK + + E K L+++ Q E+ ++ E
Sbjct: 782 LESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ----LEKE 837
Query: 417 ISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHL 476
L Q+ +D T+ ++EK E + + +KE +L+ L+ EN+
Sbjct: 838 NKRLRQQAEIKDTTLEENNVKIGNLEK----ENKTLSKEIGIYKESCVRLKELEKENK-- 891
Query: 477 SEMVMKLELGLHECSLPVSPLGS--IATRFLEEEELRSHHILERLDAHIEELKRESEKTV 534
E+V + + + L S + T+ + + + H LE++ + E L + + T
Sbjct: 892 -ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
Query: 535 RQFTALK 541
++ L+
Sbjct: 951 DRYKLLE 957
Score = 78.2 bits (191), Expect = 2e-14
Identities = 99/443 (22%), Positives = 206/443 (46%), Gaps = 65/443 (14%)
Query: 55 KIREQELKS-LRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRS 113
K+ E +L+S L+ L++ +++ L ++EE + Y Q+L+ +EL +K++
Sbjct: 954 KLLESKLESTLKKSLEIKEEKIAALEARLEE--------STNYNQQLR---QELKTVKKN 1002
Query: 114 YEKLQKKQMRE--FRGNTKNHREDRS---EIERLTAKIEEFRQKSLDWEKQRLIYQQQVS 168
YE L+++Q E + + ED E + T ++ + + + ++ E+ Q +
Sbjct: 1003 YEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQ 1062
Query: 169 SLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIE 228
+L+ Q K L Q+ +QAQ++ +++ S++ + +Q ++KL+ N T+ + +
Sbjct: 1063 ALKTQLKQLETQNNNLQAQILALQRQTVSLQ-EQNTTLQTQNAKLQVENSTLNSQSTSL- 1120
Query: 229 RLTMRVNDLVGTSMTVLQEQQQKEEKLRESEK-LLEALQEEKRELKAALQSQENLIHEAR 287
M N + + L+ + + K RE K L ++L ++ +L+ L+HE +
Sbjct: 1121 ---MNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE--------LLHERQ 1169
Query: 288 IQK-EKLQEKVKATNTQHAVEAIRPRE-ESLAEKKYTSQGQ-GDLDSVLS----QLNFTH 340
+ E L K + H + R+ E + +GQ DL+ +L ++ +
Sbjct: 1170 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLEN 1229
Query: 341 TSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL 400
+ + + AE L G + ++ T QL +E + K +++ N K E +L+
Sbjct: 1230 KNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA--- 1286
Query: 401 QGEQSYSSALEGMKMEISHLTQELHQRDITIASTK-GSSSDMEKRLRAEMQKAEDKAVEH 459
E S L ++ Q DIT STK + ++ +L+ +++ E+
Sbjct: 1287 ---------------EFSKLKEQYQQLDIT--STKLNNQCELLSQLKGNLEE------EN 1323
Query: 460 KEILDQLESLKLENRHLSEMVMK 482
+ +LDQ+++L L+NR L E M+
Sbjct: 1324 RHLLDQIQTLMLQNRTLLEQNME 1346
Score = 76.3 bits (186), Expect = 7e-14
Identities = 118/499 (23%), Positives = 210/499 (42%), Gaps = 61/499 (12%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E E Q L K ++ + K R LE K EQE L KE
Sbjct: 786 LQDLEMENQTLQKNLEELKISSK-----RLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 78 LHQQVEEHEKIKQEMTMEY---KQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHRE 134
L QQ E + +E ++ ++E K L +E+ I K S +L++ + +E
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE-----------KE 889
Query: 135 DRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQK 194
++ ++R T I+ D ++L QQ + LE L E+ + + +L++ +Q
Sbjct: 890 NKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL-EKIGLNKERLLHDEQS 948
Query: 195 LESVELSSQSEIQH-LSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQ-----EQ 248
+ +S+++ L LE + I A E +E T L TV + +Q
Sbjct: 949 TDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQ 1008
Query: 249 QQKEEKLRESE--------KLLEALQEEKRELKAALQSQENLIHEAR------IQKEKLQ 294
+Q EE++ +S K QE REL L+ ++ LI R +K+ L+
Sbjct: 1009 RQDEERMVQSSPPISGEDNKWERESQETTREL---LKVKDRLIEVERNNATLQAEKQALK 1065
Query: 295 EKVKATNTQH-----AVEAIRPREESLAEKKYTSQGQG-DLDSVLSQLNFTHTSEDLLQA 348
++K TQ+ + A++ + SL E+ T Q Q L S LN TS A
Sbjct: 1066 TQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA 1125
Query: 349 EVTCLEGSLESVSATCKQLSQELMEKYEEL----KRMEAHNNEYKAEIKKLKEQILQGEQ 404
++ + SLE+ + + + ++L Y+ L +++E + +E E ++
Sbjct: 1126 QLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEY----ESLISKHG 1181
Query: 405 SYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD 464
+ SA + +++E L +Q + KG D+EK L+ E +K + H+ +
Sbjct: 1182 TLKSAHKNLEVEHRDLEDRYNQ----LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1237
Query: 465 QLESLKLENRHLSEMVMKL 483
+ + L EN L+ +L
Sbjct: 1238 EYKKLCGENDRLNHTYSQL 1256
Score = 62.8 bits (151), Expect = 8e-10
Identities = 100/489 (20%), Positives = 205/489 (41%), Gaps = 32/489 (6%)
Query: 69 DVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEE---LCILKRSYEKLQKKQMREF 125
D++ +++ L + + H K + E+ + + +L EE L L + Q
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG 239
Query: 126 RGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQ 185
T++ + E+ AKI RQ+ + +Q L +Q++ +E + K L +++ +
Sbjct: 240 MKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 186 AQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVL 245
+ R ++ EL + E KLE +IE RV +L + +L
Sbjct: 300 SDA--RSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
Query: 246 QEQQQKEEKLR----ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN 301
+ + E++L S+KL E L++E +LKA L E E + ++K++E ++
Sbjct: 358 ETKTMLEDQLEGTRARSDKLHE-LEKENLQLKAKLHDME---MERDMDRKKIEELMEENM 413
Query: 302 TQHAVEAIRPREESLAEKKYTSQGQGDLD-SVLSQLNFTHTSEDLLQAEVTCLEGSLESV 360
T + + +ESL Q + S Q + H +L + + LE +S+
Sbjct: 414 TLEMAQK-QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Query: 361 SATCKQLS---QELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEI 417
+ T ++L + ++ +ME N +++ L+ +I+Q +QS L+ +
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS----LQNCQNLS 528
Query: 418 SHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILD-----QLESLKLE 472
L +E Q + TI + + +S K L E + ++ +++ ++ E
Sbjct: 529 KDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKE 588
Query: 473 NRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEK 532
N+ L E + + L + + + E+ E E L+ + L++E+E
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER-----AEELENELHHLEKENEL 643
Query: 533 TVRQFTALK 541
++ T LK
Sbjct: 644 LQKKITNLK 652
Score = 48.9 bits (115), Expect = 1e-05
Identities = 57/251 (22%), Positives = 115/251 (45%), Gaps = 17/251 (6%)
Query: 51 ETCLKIREQELKSLRSQLDVTHKEVGMLHQ-QVEEHEKIKQEMTMEYKQELKKLHEELCI 109
E+ +K RE +LKSL L H+++ +LH+ Q E+E + + LK H+ L +
Sbjct: 1139 ESVIKERE-DLKSLYDSLIKDHEKLELLHERQASEYESL-----ISKHGTLKSAHKNLEV 1192
Query: 110 LKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSS 169
R E + +++ +G ++ E ++E+ +E +++ E ++L +
Sbjct: 1193 EHRDLEDRYNQLLKQ-KGQLED-LEKMLKVEQEKMLLENKNHETVAAEYKKLCGEND--R 1248
Query: 170 LEAQRKALAEQSEIIQAQLVNRKQKLESVELSS---QSEIQHLSSKLERANDTICANELE 226
L L +++E++Q N K L + +L ++E L + ++ + T +
Sbjct: 1249 LNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQ 1308
Query: 227 IERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEA 286
E L+ +L + +L + Q + ++ LLE E K + + ++E
Sbjct: 1309 CELLSQLKGNLEEENRHLLDQIQTL---MLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1365
Query: 287 RIQKEKLQEKV 297
R QKEKL+EK+
Sbjct: 1366 RRQKEKLEEKI 1376
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 89.7 bits (221), Expect = 6e-18
Identities = 90/386 (23%), Positives = 182/386 (47%), Gaps = 44/386 (11%)
Query: 39 KKSEWEGRTHALETCL-----KIREQELKSLRSQLDVTHKEVGMLHQQV---EEHEKIK- 89
K EWE + E + KIREQE K R + + KE M Q+ E+ EK++
Sbjct: 369 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 428
Query: 90 -QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEE 148
+EM E ++++++L E++ ++ E+ +K+Q E + +E +++ R KI E
Sbjct: 429 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIRE 488
Query: 149 FRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQH 208
+K + E++ +Q + Q K E+ Q ++ +++K+ Q EI
Sbjct: 489 QEEKIREQEEK---MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR-----EQEEIWR 540
Query: 209 LSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK----EEKLRESEKLLEA 264
K+ + I E ++ R +++D ++EQ++K EEK+RE E+ +
Sbjct: 541 QKEKIHEQEEKIRKQEEKMWRQEEKMHD----QEEKIREQEEKVWRQEEKIREQEEKIRE 596
Query: 265 LQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQ 324
+E+ RE + Q QE + E Q+EK+ E+ + Q E +R +EE + E++
Sbjct: 597 QEEKIREQEEMTQEQEEKMGE---QEEKMCEQEEKMQEQE--EKMRRQEEKIREQE---- 647
Query: 325 GQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAH 384
+ Q E+++Q + E E C+Q +++ E+ E+++R E
Sbjct: 648 -----KKIREQEEKIREQEEMMQEQE---EKMWEQEEKMCEQ-EEKMQEQEEKMRRQEEK 698
Query: 385 NNEYKAEIKKLKEQILQGEQSYSSAL 410
E + +++ +E++ + ++ +A+
Sbjct: 699 MWEQEVRLRQQEEKMQEHQEHLEAAI 724
Score = 69.7 bits (169), Expect = 6e-12
Identities = 75/304 (24%), Positives = 141/304 (46%), Gaps = 35/304 (11%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
E + ++ + H + E + QE K I K+ E E + E KIREQE
Sbjct: 437 EEKIRELEEKMHEQEKIREQEEKRQEEEK---IREQEKRQEQEAKMWRQEE--KIREQEE 491
Query: 62 KSLRSQLDVTHKEVGMLHQQ--VEEHEKIKQEMTMEYKQELKKLHEELCILKRSY----E 115
K +R Q + ++ +H+Q + E EK +++ M ++E + EE+ K E
Sbjct: 492 K-IREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEE 550
Query: 116 KLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRK 175
K++K++ + +R K H ++ KI E +K W ++ I +Q+ + Q +
Sbjct: 551 KIRKQEEKMWRQEEKMHDQEE--------KIREQEEKV--WRQEEKIREQE-EKIREQEE 599
Query: 176 ALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVN 235
+ EQ E+ Q Q ++ E + + ++Q K+ R + I E +I ++
Sbjct: 600 KIREQEEMTQEQEEKMGEQEEKM-CEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIR 658
Query: 236 DLVGTSMTVLQEQQQK----EEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKE 291
+ ++QEQ++K EEK+ E E+ ++ +E+ R + + QE + R Q+E
Sbjct: 659 E----QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL---RQQEE 711
Query: 292 KLQE 295
K+QE
Sbjct: 712 KMQE 715
Score = 68.2 bits (165), Expect = 2e-11
Identities = 106/521 (20%), Positives = 217/521 (41%), Gaps = 60/521 (11%)
Query: 45 GRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE-------HEKIKQEMTMEYK 97
G H+ E K Q ++LR +L+ + +L Q E + +++ E +
Sbjct: 163 GGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR 222
Query: 98 QELKKLHE------ELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQ 151
+ +LH+ EL + +KK R TK E+ R T EE ++
Sbjct: 223 DLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 282
Query: 152 KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSS 211
K+ +++ + + + S ++ K L + E +A+L+ +Q+L++ E+Q +S+
Sbjct: 283 KNAKLQEKLQLVESEKSEIQLNVKELKRKLE--RAKLLLPQQQLQAEADHLGKELQSVSA 340
Query: 212 KLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRE 271
KL+ ++E L R+N QQ+EEK+ E+ ++ +E+ +E
Sbjct: 341 KLQA--------QVEENELWNRLN-------------QQQEEKMWRQEEKIQEWEEKIQE 379
Query: 272 LKAALQSQENLIHE----ARIQKEKLQEKVKATNTQHAV-----EAIRPREESLAEKKYT 322
+ ++ QE I E R Q+E + EK + Q + E +R +EE + EK+
Sbjct: 380 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 439
Query: 323 SQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLE-GSLESVSATCKQLSQELMEKYEELKRM 381
+ +L+ + + E+ Q E E + A + +++ E+ E+++
Sbjct: 440 IR---ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQ 496
Query: 382 EA---HNNEYKAEIKKLKEQILQGEQSYSSALEGM---KMEISHLTQELHQRDITIASTK 435
E E E +K++E+ + EQ E + EI +++H+++ I +
Sbjct: 497 EEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE 556
Query: 436 GSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVS 495
E+++ + +K + + +++ Q E ++ + + E K+
Sbjct: 557 EKMWRQEEKMHDQEEKIRE---QEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEE 613
Query: 496 PLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 536
+G + E+EE E EE RE EK +R+
Sbjct: 614 KMGEQEEKMCEQEEKMQEQ--EEKMRRQEEKIREQEKKIRE 652
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 89.7 bits (221), Expect = 6e-18
Identities = 112/550 (20%), Positives = 241/550 (43%), Gaps = 77/550 (14%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWE----------GRTHALETCLKIREQELKSLRSQ 67
L EAE +L + +AH+ S+++ + LE+ + + +L +L Q
Sbjct: 650 LIQIEAENSDLK----VNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQ 705
Query: 68 LD---VTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMRE 124
L+ V + + + ++E+ K E + + HE++C+ ++EK +K + +
Sbjct: 706 LEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL---AFEKAKKIHLEQ 762
Query: 125 FRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQV----SSLEAQRKALAEQ 180
H+E +IERL A++E+ Q+ + EK + QQ + LE+ + L E
Sbjct: 763 -------HKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTES 815
Query: 181 SEIIQAQLVNRKQKLESVELSSQSE---IQHLSSKLERANDTICANELEIERLTMRVNDL 237
++ + + + + L++++ E ++ L S LE IC E L + +N L
Sbjct: 816 KGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALE-----ICK-----EELVLHLNQL 865
Query: 238 VGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQ--SQENLI--HEARIQKEKL 293
G +++ E++L++ + + LQ+E + +LQ S++N+I H + Q++ L
Sbjct: 866 EG-------NKEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQML 918
Query: 294 QEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCL 353
Q++ + ++ S E++ Q + ++E L + E C
Sbjct: 919 QQETIRNGELEDTQTKLEKQVSKLEQELQKQRES-------------SAEKLRKMEEKC- 964
Query: 354 EGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQIL---QGEQSYSSAL 410
ES + Q+++E ++++ ++YK E+ K++++I+ + ++ + L
Sbjct: 965 ----ESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHL 1020
Query: 411 EGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 470
+ M + EL ++ + + E L +QK E E + +L+S
Sbjct: 1021 SQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKSTL 1080
Query: 471 LENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRES 530
+ + L +++ K +L L E + L + E E + +LE +D ++E E
Sbjct: 1081 RQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLE-MDQALKERNWEL 1139
Query: 531 EKTVRQFTAL 540
++ Q T L
Sbjct: 1140 KQRAAQVTHL 1149
Score = 87.4 bits (215), Expect = 3e-17
Identities = 111/490 (22%), Positives = 207/490 (42%), Gaps = 72/490 (14%)
Query: 42 EWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELK 101
E E + LE L+ ++Q+ K + + +++ +E +++ E E K+E
Sbjct: 765 EMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENM 824
Query: 102 KLHEELCILKR--SYEKLQKKQM---------------REFRGNT----KNHREDRSEIE 140
K E L L+ S E ++ +Q+ + GN K ++ E+
Sbjct: 825 KKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVY 884
Query: 141 RLTAKIEEFRQKSLDWEKQRLIYQ------QQVSSLEAQRKALAEQSEI-IQAQLVNRKQ 193
L +++ + +Q +I Q QQ+ E R E ++ ++ Q+ +Q
Sbjct: 885 CLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQ 944
Query: 194 KLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEE 253
+L+ SS +++ + K E A A+E +++R +V +L GT+ V E Q +E
Sbjct: 945 ELQKQRESSAEKLRKMEEKCESA-----AHEADLKR--QKVIELTGTARQVKIEMDQYKE 997
Query: 254 KLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNT-QHAVE----- 307
+L + EK + L+ + L + ++ + + + EK VK QH+ E
Sbjct: 998 ELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTE 1057
Query: 308 AIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQL 367
A++ RE E + G+L S L QL D+LQ LE
Sbjct: 1058 ALQKREVLETELQ---NAHGELKSTLRQLQ---ELRDVLQKAQLSLE------------- 1098
Query: 368 SQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQR 427
EKY +K + A E K EI+ K+++L+ +Q AL+ E+ ++
Sbjct: 1099 -----EKYTTIKDLTAELRECKMEIEDKKQELLEMDQ----ALKERNWELKQRAAQVTHL 1149
Query: 428 DITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGL 487
D+TI +G +L ++K+E +E KE Q+ESL + ++ E + + E +
Sbjct: 1150 DMTIREHRGEMEQKIIKLEGTLEKSE---LELKECNKQIESLNDKLQNAKEQLREKEFIM 1206
Query: 488 HECSLPVSPL 497
+ +S L
Sbjct: 1207 LQNEQEISQL 1216
Score = 73.9 bits (180), Expect = 3e-13
Identities = 104/469 (22%), Positives = 211/469 (44%), Gaps = 99/469 (21%)
Query: 29 MKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKI 88
+ Q+D+++ K+E E +T+A++ K++ T E+ Q+ E E
Sbjct: 1020 LSQLDMILDQTKTELEKKTNAVKELEKLQHS-----------TETELTEALQKREVLETE 1068
Query: 89 KQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEE 148
Q E K L++L E +L+++ L++K + I+ LTA++ E
Sbjct: 1069 LQNAHGELKSTLRQLQELRDVLQKAQLSLEEKY---------------TTIKDLTAELRE 1113
Query: 149 FRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQH 208
+ + D +KQ L+ Q AL E++ +L R ++ ++++ +
Sbjct: 1114 CKMEIED-KKQELLEMDQ---------ALKERNW----ELKQRAAQVTHLDMTIREHRGE 1159
Query: 209 LSSKLERANDTICANELEIERLTMRV---NDLVGTSMTVLQEQQ----QKEEKLRESEKL 261
+ K+ + T+ +ELE++ ++ ND + + L+E++ Q E+++ + +K
Sbjct: 1160 MEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKE 1219
Query: 262 LEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKY 321
+E Q+ +E+++ ++ QE I + L ++++ T E ++ LAE ++
Sbjct: 1220 IERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTR-----EQVQNSHTELAEARH 1274
Query: 322 TS-QGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQE-------LME 373
Q Q +++ + S+L ED+ KQLS+E L E
Sbjct: 1275 QQVQAQREIERLSSEL------EDM-------------------KQLSKEKDAHGNHLAE 1309
Query: 374 KYEELKRMEAH-NNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQR-DITI 431
+ K EAH +AEIKKL ++ +++Y + ISH QE H + I+
Sbjct: 1310 ELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEM------ISH--QENHAKWKISA 1361
Query: 432 ASTKGSSSDMEKRL---RAEMQKAEDKAVE-HKEILDQLESLKLENRHL 476
S K S + ++L + E+++A+D H+++ D+ E ++ N L
Sbjct: 1362 DSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEAL 1410
Score = 58.2 bits (139), Expect = 2e-08
Identities = 89/424 (20%), Positives = 168/424 (39%), Gaps = 52/424 (12%)
Query: 54 LKIREQELKSLRSQLD-VTHKEVGMLHQQVEEHEKIKQEMTMEYKQELK-KLHEELCILK 111
LKI E L+SL +L V+ E EK+ ++ + L +E +C +
Sbjct: 147 LKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKIS 206
Query: 112 RSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLE 171
S QKK + ++ + EI+ L K+ + RQ++ + L
Sbjct: 207 GSSTDFQKKPRDKMFSSSAPVDQ---EIKSLREKLNKLRQQN--------------ACLV 249
Query: 172 AQRKALAEQSEIIQAQLVNRKQKLESVELSSQ--SEIQHLSSKLERANDTICANELEIER 229
Q +L + E I +L + K+ +E + Q + + L ++ + A + +
Sbjct: 250 TQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQDKVLRE 309
Query: 230 LTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL-LEALQEEKRELKAALQSQENLIHEARI 288
N L + V++++Q +E E KL ++ L++ K+ +A Q E L + +
Sbjct: 310 AE---NKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEEL 366
Query: 289 QKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQA 348
K Q K K V+A EE + E+ T+ LQ
Sbjct: 367 SKAFQQYKKKVAEKLEKVQA----EEEILERNLTN---------------CEKENKRLQE 407
Query: 349 EVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSS 408
+ LE + +QL +E E+L+ M N+E A++ + ++ IL+ E +
Sbjct: 408 RCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELEN 467
Query: 409 ALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLES 468
E ++ + S L E + + +A+ +RL Q+ E VE + + +
Sbjct: 468 KDEILRDKFS-LMNENRELKVRVAA-------QNERLDLCQQEIESSRVELRSLEKIISQ 519
Query: 469 LKLE 472
L L+
Sbjct: 520 LPLK 523
Score = 39.3 bits (90), Expect = 0.009
Identities = 72/343 (20%), Positives = 143/343 (41%), Gaps = 60/343 (17%)
Query: 180 QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRV----- 234
+ E + A + + + +L+ E S QS + LSS N N E+L + V
Sbjct: 132 EEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHP 191
Query: 235 --------NDLVGTSMTVLQEQQQKEEKLRES----EKLLEALQEEKRELK---AALQSQ 279
++ S + Q++ +K+ S ++ +++L+E+ +L+ A L +Q
Sbjct: 192 GLLNYSPYENVCKISGSSTDFQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQ 251
Query: 280 EN--LIHEARIQKEKLQEKVKAT---NTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLS 334
+ + I E Q + K + + Q ++ EE + + Q D VL
Sbjct: 252 NHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQIINLEAEVSAQ---DKVLR 308
Query: 335 QLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKK 394
+ + Q V E SL+ C +L +L+E+ ++ KR E NE ++
Sbjct: 309 E---AENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEE 365
Query: 395 LKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGS---------SSDME--- 442
L + Q ++ + LE ++ E +E+ +R++T + S++E
Sbjct: 366 LSKAFQQYKKKVAEKLEKVQAE-----EEILERNLTNCEKENKRLQERCGLYKSELEILK 420
Query: 443 ---KRLRAEMQKAEDK----AVEHKEILDQLES-----LKLEN 473
++L+ E ++K AV++ E++ QL LKLE+
Sbjct: 421 EKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLES 463
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 89.0 bits (219), Expect = 1e-17
Identities = 124/552 (22%), Positives = 248/552 (44%), Gaps = 54/552 (9%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
+AELQ + + + VA ++++E T A++ ++ E + K L +L + V ++ +
Sbjct: 1360 KAELQRALSKANTEVAQWRTKYE--TDAIQRTEELEEAK-KKLAQRLQAAEEHVEAVNAK 1416
Query: 82 VEEHEKIKQEMTMEYKQ---ELKKLHEELCIL---KRSYEKLQ---KKQMREFRGNTKNH 132
EK KQ + E + ++++ + L +R+++K+ K++ E +
Sbjct: 1417 CASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1476
Query: 133 REDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVN-- 190
+++ + KI+ ++SLD Q+ +L+ + K L ++ + Q+
Sbjct: 1477 QKEARSLGTELFKIKNAYEESLD----------QLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 191 -RKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQ 249
R +LE ++ + E L + LE A ++ E +I R+ + +N + + E+
Sbjct: 1527 KRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD 1586
Query: 250 QKEEKLRESE-KLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN--TQHAV 306
++ ++L+ + +++E++Q L A ++S+ + I + + L E N + A
Sbjct: 1587 EEIDQLKRNHIRIVESMQST---LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1643
Query: 307 EAIRPREESLAEKKYTSQGQGDL----DSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSA 362
EA+R + K T D + + QL +LLQAE+ L +LE
Sbjct: 1644 EALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1703
Query: 363 TCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI--LQGE-----QSYSSALEGMKM 415
+ K QEL++ E ++ + N KKL+ I +QGE Q +A E K
Sbjct: 1704 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKK 1763
Query: 416 EISH---LTQELHQRDITIASTKGSSSDME---KRLRAEMQKAEDKAVE-HKEILDQLES 468
I+ + +EL + T A + +ME K L+ + +AE A++ K+ + +LE+
Sbjct: 1764 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA 1823
Query: 469 --LKLENRHLSEMVMKLEL--GLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIE 524
+LE SE E GL + V L + T + LR ++++L A ++
Sbjct: 1824 RVRELEGEVESEQKRNAEAVKGLRKHERRVKEL-TYQTEEDRKNILRLQDLVDKLQAKVK 1882
Query: 525 ELKRESEKTVRQ 536
KR++E+ Q
Sbjct: 1883 SYKRQAEEAEEQ 1894
Score = 81.6 bits (200), Expect = 2e-15
Identities = 114/586 (19%), Positives = 245/586 (41%), Gaps = 84/586 (14%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E ++ L+K+ + + ++E EG A E C +L + QL+ KEV ++
Sbjct: 880 EEKMVTLLKEKNDLQLQVQAEAEGLADAEERC-----DQLIKTKIQLEAKIKEVT---ER 931
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHRED 135
E+ E+I E+T + + KL +E LK+ + L+ +K+ KN E+
Sbjct: 932 AEDEEEINAELTAKKR----KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 987
Query: 136 RSEIERLTAKI-------EEFRQKSLD-----------WEKQRLIYQQQVSSLEA---QR 174
+ ++ AK+ +E Q++LD K ++ +QQV LE Q
Sbjct: 988 MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE 1047
Query: 175 KALAEQSEIIQAQLV--------------NRKQKLESVELSSQSEIQHLSSKLERANDTI 220
K L E + +L N KQ+L+ + EI +L SK+E
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG 1107
Query: 221 CANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQE 280
+ +I+ L R+ +L + + E++ + + LE + E E A +Q
Sbjct: 1108 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1167
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAIRPRE---ESLAE---------------KKYT 322
+ + + +K++ ++ QH A R+ +S+AE +K
Sbjct: 1168 EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 1227
Query: 323 SQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRME 382
S+ + ++D + S + ++ L+ LE L + + ++ + + + + R++
Sbjct: 1228 SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ 1287
Query: 383 AHNNEYKAEI---KKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSS 439
+ E+ ++ + L Q+ +G+Q+++ +E +K + L +E+ ++ + + S
Sbjct: 1288 TESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ---LEEEIKAKNALAHALQSSRH 1344
Query: 440 DMEKRLRAEMQKAEDKAVEHKEILDQ--LESLKLENRHLSEMVMKLELGLHECSLPVSPL 497
D + LR + ++ ++ E + L + E + ++ ++ + + E L E ++
Sbjct: 1345 DCD-LLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE-ELEEAKKKLAQR 1402
Query: 498 GSIATRFLEEEELRSHHI---LERLDAHIEELKRESEKTVRQFTAL 540
A +E + + +RL +E+L + E+T AL
Sbjct: 1403 LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL 1448
Score = 58.5 bits (140), Expect = 1e-08
Identities = 90/447 (20%), Positives = 183/447 (40%), Gaps = 82/447 (18%)
Query: 152 KSLDWEKQRLIYQQQVSSLEAQ-RKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLS 210
KS + EK+ +++ ++ + K+ A++ E+ + + K+K ++L Q+E + L+
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK-NDLQLQVQAEAEGLA 905
Query: 211 SKLERANDTICAN---ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQE 267
ER + I E +I+ +T R D E++ E + KL ++
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAED----------EEEINAELTAKKRKL----ED 951
Query: 268 EKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAI-----RPREESLAEKKYT 322
E ELK + E + A+++KEK + K N + + + +E A ++
Sbjct: 952 ECSELKKDIDDLELTL--AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1009
Query: 323 SQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLE------------------------ 358
Q DL + ++N ++ L+ +V LEGSLE
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069
Query: 359 ----SVSATCKQLSQELMEKYEELKRMEA--------------HNNEYKAEIKKLKEQIL 400
+ +QL ++L +K E+ +++ E +A I++L+E+I
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI- 1128
Query: 401 QGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK----AEDKA 456
+ E++ + E + ++S +E+ +R + +M K+ AE QK E+
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188
Query: 457 VEH--------KEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEE 508
++H K+ D + L + +L + KLE E + + L S + +
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS-NVETVSKA 1247
Query: 509 ELRSHHILERLDAHIEELKRESEKTVR 535
+ + L+ + ELK + E+ R
Sbjct: 1248 KGNLEKMCRTLEDQLSELKSKEEEQQR 1274
Score = 42.0 bits (97), Expect = 0.001
Identities = 40/187 (21%), Positives = 90/187 (48%), Gaps = 3/187 (1%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHK-EVGML 78
+ E + ++ + +M K E + H LE K EQ +K L+ +LD + +
Sbjct: 1756 NAEEKAKKAITDAAMMAEELKKEQDTSAH-LERMKKNMEQTVKDLQLRLDEAEQLALKGG 1814
Query: 79 HQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSE 138
+Q+++ E +E+ E + E K+ E + L R +E+ K+ + + KN +
Sbjct: 1815 KKQIQKLEARVRELEGEVESEQKRNAEAVKGL-RKHERRVKELTYQTEEDRKNILRLQDL 1873
Query: 139 IERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
+++L AK++ +++++ + E+Q + L+ + + E+++I ++Q+ + K V
Sbjct: 1874 VDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
Query: 199 ELSSQSE 205
SE
Sbjct: 1934 HTKVISE 1940
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 89.0 bits (219), Expect = 1e-17
Identities = 124/552 (22%), Positives = 248/552 (44%), Gaps = 54/552 (9%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
+AELQ + + + VA ++++E T A++ ++ E + K L +L + V ++ +
Sbjct: 1360 KAELQRALSKANTEVAQWRTKYE--TDAIQRTEELEEAK-KKLAQRLQAAEEHVEAVNAK 1416
Query: 82 VEEHEKIKQEMTMEYKQ---ELKKLHEELCIL---KRSYEKLQ---KKQMREFRGNTKNH 132
EK KQ + E + ++++ + L +R+++K+ K++ E +
Sbjct: 1417 CASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1476
Query: 133 REDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVN-- 190
+++ + KI+ ++SLD Q+ +L+ + K L ++ + Q+
Sbjct: 1477 QKEARSLGTELFKIKNAYEESLD----------QLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 191 -RKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQ 249
R +LE ++ + E L + LE A ++ E +I R+ + +N + + E+
Sbjct: 1527 KRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKD 1586
Query: 250 QKEEKLRESE-KLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN--TQHAV 306
++ ++L+ + +++E++Q L A ++S+ + I + + L E N + A
Sbjct: 1587 EEIDQLKRNHIRIVESMQST---LDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1643
Query: 307 EAIRPREESLAEKKYTSQGQGDL----DSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSA 362
EA+R + K T D + + QL +LLQAE+ L +LE
Sbjct: 1644 EALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTER 1703
Query: 363 TCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQI--LQGE-----QSYSSALEGMKM 415
+ K QEL++ E ++ + N KKL+ I +QGE Q +A E K
Sbjct: 1704 SRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKK 1763
Query: 416 EISH---LTQELHQRDITIASTKGSSSDME---KRLRAEMQKAEDKAVE-HKEILDQLES 468
I+ + +EL + T A + +ME K L+ + +AE A++ K+ + +LE+
Sbjct: 1764 AITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA 1823
Query: 469 --LKLENRHLSEMVMKLEL--GLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIE 524
+LE SE E GL + V L + T + LR ++++L A ++
Sbjct: 1824 RVRELEGEVESEQKRNAEAVKGLRKHERRVKEL-TYQTEEDRKNILRLQDLVDKLQAKVK 1882
Query: 525 ELKRESEKTVRQ 536
KR++E+ Q
Sbjct: 1883 SYKRQAEEAEEQ 1894
Score = 81.6 bits (200), Expect = 2e-15
Identities = 114/586 (19%), Positives = 245/586 (41%), Gaps = 84/586 (14%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E ++ L+K+ + + ++E EG A E C +L + QL+ KEV ++
Sbjct: 880 EEKMVTLLKEKNDLQLQVQAEAEGLADAEERC-----DQLIKTKIQLEAKIKEVT---ER 931
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHRED 135
E+ E+I E+T + + KL +E LK+ + L+ +K+ KN E+
Sbjct: 932 AEDEEEINAELTAKKR----KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 987
Query: 136 RSEIERLTAKI-------EEFRQKSLD-----------WEKQRLIYQQQVSSLEA---QR 174
+ ++ AK+ +E Q++LD K ++ +QQV LE Q
Sbjct: 988 MAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQE 1047
Query: 175 KALAEQSEIIQAQLV--------------NRKQKLESVELSSQSEIQHLSSKLERANDTI 220
K L E + +L N KQ+L+ + EI +L SK+E
Sbjct: 1048 KKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALG 1107
Query: 221 CANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQE 280
+ +I+ L R+ +L + + E++ + + LE + E E A +Q
Sbjct: 1108 IQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQI 1167
Query: 281 NLIHEARIQKEKLQEKVKATNTQHAVEAIRPRE---ESLAE---------------KKYT 322
+ + + +K++ ++ QH A R+ +S+AE +K
Sbjct: 1168 EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEK 1227
Query: 323 SQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRME 382
S+ + ++D + S + ++ L+ LE L + + ++ + + + + R++
Sbjct: 1228 SEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQ 1287
Query: 383 AHNNEYKAEI---KKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSS 439
+ E+ ++ + L Q+ +G+Q+++ +E +K + L +E+ ++ + + S
Sbjct: 1288 TESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ---LEEEIKAKNALAHALQSSRH 1344
Query: 440 DMEKRLRAEMQKAEDKAVEHKEILDQ--LESLKLENRHLSEMVMKLELGLHECSLPVSPL 497
D + LR + ++ ++ E + L + E + ++ ++ + + E L E ++
Sbjct: 1345 DCD-LLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTE-ELEEAKKKLAQR 1402
Query: 498 GSIATRFLEEEELRSHHI---LERLDAHIEELKRESEKTVRQFTAL 540
A +E + + +RL +E+L + E+T AL
Sbjct: 1403 LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAAL 1448
Score = 58.5 bits (140), Expect = 1e-08
Identities = 90/447 (20%), Positives = 183/447 (40%), Gaps = 82/447 (18%)
Query: 152 KSLDWEKQRLIYQQQVSSLEAQ-RKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLS 210
KS + EK+ +++ ++ + K+ A++ E+ + + K+K ++L Q+E + L+
Sbjct: 847 KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEK-NDLQLQVQAEAEGLA 905
Query: 211 SKLERANDTICAN---ELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQE 267
ER + I E +I+ +T R D E++ E + KL ++
Sbjct: 906 DAEERCDQLIKTKIQLEAKIKEVTERAED----------EEEINAELTAKKRKL----ED 951
Query: 268 EKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAI-----RPREESLAEKKYT 322
E ELK + E + A+++KEK + K N + + + +E A ++
Sbjct: 952 ECSELKKDIDDLELTL--AKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAH 1009
Query: 323 SQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLE------------------------ 358
Q DL + ++N ++ L+ +V LEGSLE
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQ 1069
Query: 359 ----SVSATCKQLSQELMEKYEELKRMEA--------------HNNEYKAEIKKLKEQIL 400
+ +QL ++L +K E+ +++ E +A I++L+E+I
Sbjct: 1070 ESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEI- 1128
Query: 401 QGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK----AEDKA 456
+ E++ + E + ++S +E+ +R + +M K+ AE QK E+
Sbjct: 1129 EAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1188
Query: 457 VEH--------KEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEE 508
++H K+ D + L + +L + KLE E + + L S + +
Sbjct: 1189 LQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS-NVETVSKA 1247
Query: 509 ELRSHHILERLDAHIEELKRESEKTVR 535
+ + L+ + ELK + E+ R
Sbjct: 1248 KGNLEKMCRTLEDQLSELKSKEEEQQR 1274
Score = 42.0 bits (97), Expect = 0.001
Identities = 40/187 (21%), Positives = 90/187 (48%), Gaps = 3/187 (1%)
Query: 20 SCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHK-EVGML 78
+ E + ++ + +M K E + H LE K EQ +K L+ +LD + +
Sbjct: 1756 NAEEKAKKAITDAAMMAEELKKEQDTSAH-LERMKKNMEQTVKDLQLRLDEAEQLALKGG 1814
Query: 79 HQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSE 138
+Q+++ E +E+ E + E K+ E + L R +E+ K+ + + KN +
Sbjct: 1815 KKQIQKLEARVRELEGEVESEQKRNAEAVKGL-RKHERRVKELTYQTEEDRKNILRLQDL 1873
Query: 139 IERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
+++L AK++ +++++ + E+Q + L+ + + E+++I ++Q+ + K V
Sbjct: 1874 VDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
Query: 199 ELSSQSE 205
SE
Sbjct: 1934 HTKVISE 1940
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 88.6 bits (218), Expect = 1e-17
Identities = 128/589 (21%), Positives = 256/589 (43%), Gaps = 83/589 (14%)
Query: 3 ALLEGIQNRGHGGGFL-------TSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLK 55
AL +Q+ H L T +AELQ ++ + + VA ++++E T A++ +
Sbjct: 1328 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEE 1385
Query: 56 IREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQ---ELKKLHEELCIL-- 110
+ E + K L +L + V ++ + EK K + E + ++++ + L
Sbjct: 1386 LEEAK-KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDK 1444
Query: 111 -KRSYEKL-------QKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEKQRLI 162
+R+++K+ ++ E + K R +E+ +L EE + ++++
Sbjct: 1445 KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN 1504
Query: 163 YQQQVSSLEAQRKALAE---QSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDT 219
Q+++S L Q + + + E ++ QL K +L+S +++ ++H K+ RA
Sbjct: 1505 LQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLE 1564
Query: 220 ICANELEIERLT--------------MRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEAL 265
+ EIER +RV D + TS+ E + + E LR +K+
Sbjct: 1565 FNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDA--ETRSRNEALRVKKKM---- 1618
Query: 266 QEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQG 325
+ + E++ L + EA+ Q + LQ +K T Q +A+R
Sbjct: 1619 EGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ-LDDAVRAN------------- 1664
Query: 326 QGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHN 385
D + + +LLQAE+ L +E + K QEL+E E ++ + + N
Sbjct: 1665 ----DDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQN 1720
Query: 386 ----NEYK---AEIKKLKEQILQGEQSYSSALEGMKMEISH---LTQELHQRDITIASTK 435
N+ K A++ +L+ ++ + Q +A E K I+ + +EL + T A +
Sbjct: 1721 TSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1780
Query: 436 GSSSDME---KRLRAEMQKAEDKAVE-HKEILDQLES--LKLENRHLSEMVMKLE--LGL 487
+ME K L+ + +AE A++ K+ L +LE+ +LEN +E E G+
Sbjct: 1781 RMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGM 1840
Query: 488 HECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 536
+ + L + T + LR ++++L ++ KR++E+ Q
Sbjct: 1841 RKSERRIKEL-TYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQ 1888
Score = 78.6 bits (192), Expect = 1e-14
Identities = 103/513 (20%), Positives = 219/513 (42%), Gaps = 86/513 (16%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E ++ L+++ + + ++E + A E C +Q +K+ + QL+ KE ++++
Sbjct: 874 EEKMVSLLQEKNDLQLQVQAEQDNLADAEERC----DQLIKN-KIQLEAKVKE---MNER 925
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQ------KKQMREFRGNTKNHRED 135
+E+ E++ E+T + + KL +E LKR + L+ +K+ KN E+
Sbjct: 926 LEDEEEMNAELTAKKR----KLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEE 981
Query: 136 RSEIERLTAK-------IEEFRQKSLD-----------WEKQRLIYQQQVSSLEAQRKAL 177
+ ++ + AK ++E Q++LD K ++ +QQV LE
Sbjct: 982 MAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGS---- 1037
Query: 178 AEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVND- 236
EQ + ++ L K+KLE +Q I L + ++ ++ + + E+ L R+ D
Sbjct: 1038 LEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDE 1097
Query: 237 --LVGTSMTVLQEQQQKEEKLRES-----------EKL-------LEALQEEKRELKAAL 276
L L+E Q + E+L E EKL LE + E E A
Sbjct: 1098 QALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGAT 1157
Query: 277 QSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPRE---ESLAE--------------- 318
Q + + + +K++ ++ QH A R+ +S+AE
Sbjct: 1158 SVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL 1217
Query: 319 KKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEEL 378
+K S+ + +LD V S + ++ L+ LE + + ++ + + + +
Sbjct: 1218 EKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQR 1277
Query: 379 KRMEAHNNEYKAEI---KKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTK 435
+++ N E ++ + L Q+ +G+ +Y+ LE +K + L +E+ ++ + +
Sbjct: 1278 AKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQ---LEEEVKAKNALAHALQ 1334
Query: 436 GSSSDMEKRLRAEMQKAEDKAVEHKEILDQLES 468
+ D + LR + ++ + E + +L + S
Sbjct: 1335 SARHDCD-LLREQYEEETEAKAELQRVLSKANS 1366
Score = 59.3 bits (142), Expect = 9e-09
Identities = 93/493 (18%), Positives = 212/493 (43%), Gaps = 52/493 (10%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER- 141
EE ++K+ + + K+L E++ L + LQ + E + N + E ++ +
Sbjct: 854 EEFTRLKEALEKSEARR-KELEEKMVSLLQEKNDLQLQVQAE-QDNLADAEERCDQLIKN 911
Query: 142 ---LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESV 198
L AK++E ++ D E+ + LE + L + ++ L K+E
Sbjct: 912 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLA----KVEKE 967
Query: 199 ELSSQSEIQHLSSKLERANDTIC-----------ANELEIERLTM---RVNDLVGTSMTV 244
+ ++++++++L+ ++ ++ I A++ ++ L +VN L + +
Sbjct: 968 KHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKL 1027
Query: 245 LQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQH 304
Q+ E L + +K+ L+ KR+L+ L+ + I + K++L E++K + +
Sbjct: 1028 EQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFE- 1086
Query: 305 AVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATC 364
+ A+ R E E+ SQ Q L + +++ E+ L+AE T +E + +
Sbjct: 1087 -LNALNARIED--EQALGSQLQKKLKELQARI---EELEEELEAERTA-RAKVEKLRSDL 1139
Query: 365 KQLSQELMEKYEELKRMEA----HNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHL 420
+ +E+ E+ EE + N + +AE +K++ + + + + ++ + +
Sbjct: 1140 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1199
Query: 421 TQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMV 480
EL ++ + K + + E+ +D ++I+ +L+ R L + +
Sbjct: 1200 VAELGEQIDNLQRVKQKLEKEKSEFKLEL---DDVTSNMEQIIKAKANLEKMCRTLEDQM 1256
Query: 481 MKLELGLHECSLPVSPL-----------GSIATRFLEEEELRSHHILERL--DAHIEELK 527
+ E V+ L G ++ + E+E L S +L +E+LK
Sbjct: 1257 NEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLK 1316
Query: 528 RESEKTVRQFTAL 540
R+ E+ V+ AL
Sbjct: 1317 RQLEEEVKAKNAL 1329
Score = 33.5 bits (75), Expect = 0.51
Identities = 43/252 (17%), Positives = 109/252 (43%), Gaps = 39/252 (15%)
Query: 23 AELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV 82
+E +L+ + + ++K + + L+T ++ QE ++ + + M+ +++
Sbjct: 1710 SERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEEL 1769
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERL 142
+ K++ T + + +KK E+ +K +L + + +G K ++++L
Sbjct: 1770 K-----KEQDTSAHLERMKKNMEQT--IKDLQHRLDEAEQIALKGGKK-------QLQKL 1815
Query: 143 TAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSS 202
A++ E + LEA++K AE + + RK + EL+
Sbjct: 1816 EARVRELE-----------------NELEAEQKRNAESVKGM------RKSERRIKELTY 1852
Query: 203 QSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLL 262
Q+E L R D + +L+++ + + + T L + ++ + +L E+E+
Sbjct: 1853 QTEEDR--KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA 1910
Query: 263 EALQEEKRELKA 274
+ + + +L+A
Sbjct: 1911 DIAESQVNKLRA 1922
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 88.6 bits (218), Expect = 1e-17
Identities = 119/524 (22%), Positives = 225/524 (42%), Gaps = 92/524 (17%)
Query: 58 EQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKL 117
+Q +K R ++ +E+ H + E Q+ E + EL+K EEL +K E+
Sbjct: 637 QQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQH 696
Query: 118 QKKQMREFRGNTKNHRED-----RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEA 172
Q ++R+ + ++ RSE A IEE Q D + + ++Q L
Sbjct: 697 QT-EIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRK 755
Query: 173 QRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTM 232
+ + L ++ ++ + Q+++ ++ +E+Q L +E A + E+ R
Sbjct: 756 RERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNV---EVLASRSNT 812
Query: 233 RVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEK 292
D GT M V + LQEE +L+ + E + + + Q E
Sbjct: 813 SEQDQAGTEMRV------------------KLLQEENEKLQGRSEELERRVAQLQRQIED 854
Query: 293 LQ-EKVKATNTQHAVEA-IRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEV 350
L+ ++ KA T E IR EE+L + + + ++V ++ L+ E+
Sbjct: 855 LKGDEAKAKETLKKYEGEIRQLEEALVHAR-----KEEKEAV--------SARRALENEL 901
Query: 351 TCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAE-------IKKLKEQILQ-G 402
+G+L + KQLS++L E+ E+ +++ NE + E I+KL++++
Sbjct: 902 EAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIV 961
Query: 403 EQSYSSALE-----------------GMKMEISHLTQELHQRDITIASTKGSSSDMEKRL 445
E S +S LE M+ ++ T E + +T + ME+ L
Sbjct: 962 EASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEEL 1021
Query: 446 RAEMQKAEDKAVEHKEILDQ-LESLKLE---NRHL----SEMVMKLELGLHECSLPVSPL 497
R + Q+A+D+A+ +++L+Q L+ L+ E HL S +V ++E + + +
Sbjct: 1022 R-DYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEME---- 1076
Query: 498 GSIATRFLEEEELRSHHILERLD---AHIEELKRE--SEKTVRQ 536
LEEE S + ER+ +E+L+ E E+ RQ
Sbjct: 1077 -------LEEERNNSDLLSERISRSREQMEQLRNELLQERAARQ 1113
Score = 77.4 bits (189), Expect = 3e-14
Identities = 129/605 (21%), Positives = 251/605 (41%), Gaps = 113/605 (18%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L E EL++ ++++ V ++ + + L+ L EL S + D +E G
Sbjct: 672 LEESEGELRKNLEEL-FQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSED---REKGA 727
Query: 78 LHQQV--------------EEHEKI----KQEMT----------MEYKQELKKLHE---- 105
L +++ EE E + ++E+T + QE+ KL E
Sbjct: 728 LIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDA 787
Query: 106 ELCILKRSYEKLQKK-QMREFRGNTKNHREDRSE--IERLTAKIEEFRQKSLDWEKQRLI 162
EL L+ S E+ K ++ R NT + +E ++ L + E+ + +S + E++
Sbjct: 788 ELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQ 847
Query: 163 YQQQVSSL--------EAQRKALAEQSEIIQAQLVNRKQKLESVEL-------------- 200
Q+Q+ L E +K E ++ +A + RK++ E+V
Sbjct: 848 LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGN 907
Query: 201 --SSQSEIQHLSSKLERAND-----TICANELE---------IERLTMRVNDLVGTSMTV 244
+ E + LS KL+ ++ NE+E IE+L + D+V S T
Sbjct: 908 LSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTS 967
Query: 245 LQEQQQ-----KEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKA 299
E Q KE+ RE ++ L+E+ E + + + + E R+ +E+L++ +A
Sbjct: 968 TLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRA 1027
Query: 300 -----TNTQHAVEAIRPREESLAEKKYTSQGQG----DLDSVLSQLNF----THTSEDLL 346
T Q + ++ E L K + + ++ +SQL + DLL
Sbjct: 1028 QDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLL 1087
Query: 347 QAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSY 406
++ +E QL EL+++ + +E + + K LK +I+ E SY
Sbjct: 1088 SERISRSREQME-------QLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSY 1140
Query: 407 SSALEG----MKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEI 462
S+ EG M+ I+ L L + A+ + S+ +E++++ + + +D EH +
Sbjct: 1141 RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDD---EHLSL 1197
Query: 463 LDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAH 522
DQ + L L + + V + E + L R LEE+ + H+ +L++
Sbjct: 1198 TDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKL----QRELEEQMDMNEHLQGQLNSM 1253
Query: 523 IEELK 527
++L+
Sbjct: 1254 KKDLR 1258
Score = 60.8 bits (146), Expect = 3e-09
Identities = 101/456 (22%), Positives = 185/456 (40%), Gaps = 86/456 (18%)
Query: 150 RQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL--ESVELSSQSEI- 206
R+ +L +EK + + + S + +A SE+ L+ +K KL E EL Q ++
Sbjct: 576 RKVNLVFEKIQTLKSRAAGSAQGNNQACNSTSEV--KDLLEQKSKLTIEVAELQRQLQLE 633
Query: 207 ----QHLSSKLERA-----------NDTICANELEIERLTMRVNDLVGTSMTVLQEQQQK 251
Q++ + ER N+ + N +RL +L + Q + ++
Sbjct: 634 VKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMER 693
Query: 252 EEKLRESEKLLEALQEEKRELKAALQSQEN----LIHEARIQKEKLQEKVKATNTQHAVE 307
E+ E L + L E EL +A +S++ LI E K+ LQ+ + A Q +
Sbjct: 694 EQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQE--D 751
Query: 308 AIRPREESL-----AEKKYTSQGQGDLDSVLSQLNF----------------------TH 340
+R RE L A K+ S ++D + Q + ++
Sbjct: 752 LLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASRSN 811
Query: 341 TSED----------LLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNE--- 387
TSE LLQ E L+G E + QL +++ E+LK EA E
Sbjct: 812 TSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI----EDLKGDEAKAKETLK 867
Query: 388 -YKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLR 446
Y+ EI++L+E ++ + A+ + L EL ++ T + ++L+
Sbjct: 868 KYEGEIRQLEEALVHARKEEKEAVSARRA----LENELEAAQGNLSQTTQEQKQLSEKLK 923
Query: 447 AEMQKAEDKAVEHKEILDQLES-LKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFL 505
E E KE L +L++ ++ E HL + + KL+ + + L
Sbjct: 924 EES--------EQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQL 975
Query: 506 EEEELRSHHILERLDAHIEELKRESEKTVRQFTALK 541
+E + ++ L + ++E E+EK+ + TA+K
Sbjct: 976 DEYKEKNRRELAEMQRQLKEKTLEAEKS--RLTAMK 1009
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 88.2 bits (217), Expect = 2e-17
Identities = 116/543 (21%), Positives = 233/543 (42%), Gaps = 53/543 (9%)
Query: 31 QIDIMVAHKKSE--WEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKI 88
Q+D+ A K+ E WE TH LE L+ E+ L++ L +E + +++ E
Sbjct: 644 QVDLAEAEKRREALWEKNTH-LEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ 702
Query: 89 KQEMTMEYKQ---ELKKLHEELCILKRSYEKL-QKKQMREFRGNT-KNHREDRSEIERLT 143
++ T + +Q E K+ E L + E L ++K E R + R+D +E +
Sbjct: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Query: 144 AKIEEFRQKSL-DWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSS 202
+ +E + SL + ++Q + + LE Q + + + E+IQ ++ K +L++ +
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQA 822
Query: 203 QSEIQHLSSKLERAN-DTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESE-- 259
+ E + +L +A + A E + VN L +E+ +KE + E
Sbjct: 823 EQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQL--------REKWEKERSWHQQELA 874
Query: 260 KLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEK 319
K LE+L+ EK EL+ L+ Q+ + + Q+E+ + + ++ Q +E + R L
Sbjct: 875 KALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETL 934
Query: 320 KYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLE----------------------GSL 357
T + D L +L + L + E T + +L
Sbjct: 935 LQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAAL 994
Query: 358 ESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEI 417
+ S++ Q +L ++ E+LK ++ + +++ ++ L+ Q Y+ + ++ E
Sbjct: 995 QEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREK 1054
Query: 418 SHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLS 477
+ LT L +++ + + + S ++ L A Q ++ E KE+ Q+E L+ E +
Sbjct: 1055 ASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKE 1114
Query: 478 EMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQF 537
+ E L L + + E++LR+ L +A +L+ T Q
Sbjct: 1115 ADFLAQEAQL---------LEELEASHITEQQLRAS--LWAQEAKAAQLQLRLRSTESQL 1163
Query: 538 TAL 540
AL
Sbjct: 1164 EAL 1166
Score = 87.4 bits (215), Expect = 3e-17
Identities = 105/468 (22%), Positives = 209/468 (44%), Gaps = 77/468 (16%)
Query: 24 ELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVE 83
ELQ+L +Q+ +KS+WEG+ ++LE+ L + + SL+S+L E+ + Q E
Sbjct: 1286 ELQDLQRQLS-QNQEEKSKWEGKQNSLESELMELHETMASLQSRL--RRAELQRMEAQGE 1342
Query: 84 EH--EKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+ K+ +T + + H + +++ + + E + R RS ++
Sbjct: 1343 RELLQAAKENLTAQVE------HLQAAVVEARAQASAAGILEE------DLRTARSALKL 1390
Query: 142 LTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELS 201
++E R+++ Q L Q+Q AQ KAL E ++ L R++++E++
Sbjct: 1391 KNEEVESERERA-----QAL--QEQGELKVAQGKALQENLALLTQTLAEREEEVETL--- 1440
Query: 202 SQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLR----- 256
+ +IQ L + E + L++++ V+ + QEQ Q+ EK R
Sbjct: 1441 -RGQIQELEKQREMQKAALELLSLDLKKRNQEVD--------LQQEQIQELEKCRSVLEH 1491
Query: 257 ------ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIR 310
E E+ L +E+ REL+ ++Q N++ ++ EK + +E+ R
Sbjct: 1492 LPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQ---------MIESQR 1542
Query: 311 PREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQE 370
+ + L ++ T L+ + +L H + Q + LEG E+ L+ +
Sbjct: 1543 GQVQDLKKQLVT------LECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLD 1596
Query: 371 LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSS---ALEGMKMEISHLTQELHQR 427
L E+ +EL+ + ++ ++ L ++ + +Q S +E ++ + HLTQ+L +R
Sbjct: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERR 1656
Query: 428 DITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQ-LESLKLENR 474
D + K +Q ED+ +IL++ LE +KL R
Sbjct: 1657 DQELMLQK-----------ERIQVLEDQRTRQTKILEEDLEQIKLSLR 1693
Score = 78.6 bits (192), Expect = 1e-14
Identities = 125/595 (21%), Positives = 249/595 (41%), Gaps = 93/595 (15%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
L C+ + L +Q D +WE AL L+ E +L Q EV
Sbjct: 409 LAGCQEAVNLLQQQHD--------QWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDS 460
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRS 137
L ++ E +K ++E+ +Q+L+ L +E L+R +LQ Q +G + +E+
Sbjct: 461 LSKERELLQKAREEL----RQQLEVLEQEAWRLRRVNVELQL-QGDSAQGQKEEQQEELH 515
Query: 138 ----EIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQ 193
E ERL + K + + + ++ + S + + L ++ + A L +Q
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 194 ---KLESVELSSQSEIQHLSS---KLERANDTICANELEIERLTMRVNDLVGTSMTVLQE 247
+L S E + ++E+ L + KL N+ + +++ + + +++ + + + ++
Sbjct: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 248 QQQKEEKLR----ESEKLLEALQEEKRELKAALQSQENLIHEAR-----IQKEKLQEKVK 298
+Q L+ E+EK EAL E+ L+A LQ E E + IQ+EK + + K
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK 695
Query: 299 ATNTQHAVEA-----------IRPREESLAEKKYTSQG---------------QGDLDSV 332
+ ++H EA + +EE LA + + D +
Sbjct: 696 LSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDL 755
Query: 333 LSQLNFTHTSEDLLQAE----------VTCLEGSLESVSATCKQLSQELMEKYEELK-RM 381
QL ++++LL++ + +G LE T Q + + + LK +
Sbjct: 756 AEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLEL 815
Query: 382 EAHNNEYKAEIKKLKEQILQGEQSYSSALEGMK----MEISHLTQE------LHQRDITI 431
+ ++ + E Q+ Q EQ +ALE K E++ L ++ HQ+++
Sbjct: 816 DTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAK 875
Query: 432 ASTKGSSSDMEKRLRAEMQKAEDKAV--EHKEILDQLES------LKLENRHLS--EMVM 481
A ME +R + Q+ E +A+ + +E Q ES L+ E +S E ++
Sbjct: 876 ALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLL 935
Query: 482 KLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 536
+ + L + S + L + ++ ++L+ L ++E +RE ++ RQ
Sbjct: 936 QTQKELADASQQLERL----RQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQ 986
Score = 75.5 bits (184), Expect = 1e-13
Identities = 124/572 (21%), Positives = 237/572 (41%), Gaps = 95/572 (16%)
Query: 50 LETCLKIREQELKSLRSQLDVTHKEV----GMLHQQVEEHEKIKQEMTMEYKQELKKLHE 105
L ++ REQ+L R Q+ K+ +L Q+ E EK K +M + +++ L +
Sbjct: 1492 LPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK-KDQMIESQRGQVQDLKK 1550
Query: 106 EL----CI---LKRSYEKL--QKKQMREFRGNTKNHR----------EDRS-EIERLTAK 145
+L C+ L+ ++ K+ Q+K ++E G + R E+RS E++ +++
Sbjct: 1551 QLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ 1610
Query: 146 IEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSE 205
I + S ++ Q+V S Q + L Q E + L R Q+L + +
Sbjct: 1611 IHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQEL----MLQKER 1666
Query: 206 IQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEK----------- 254
IQ L + R I +LE +L++R T+ L +++ +E K
Sbjct: 1667 IQVLEDQRTRQTK-ILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLE 1725
Query: 255 -----LRESEKLLEALQE---EKRELKAALQSQENLIHE-----ARIQKEKLQE-KVKAT 300
LR+ EK +E QE E +ELK L+ Q +H + + ++ QE V
Sbjct: 1726 HMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQ 1785
Query: 301 NTQHAVEAIRPREESLAEK-----KYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEG 355
Q A E +E+SL + + +Q +L+++ + E+ ++ + L+G
Sbjct: 1786 QLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQG 1845
Query: 356 SLESVSATCKQLSQELMEKYEELKRME---------------------AHNNEYKAEIKK 394
+LE T K+ EL + E+ +R+E A + E + +
Sbjct: 1846 ALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLA 1905
Query: 395 LKEQILQGEQSY---SSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQK 451
L++Q + Q + + AL+ ++ + +E Q + + SS E+ RA +
Sbjct: 1906 LQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEA 1965
Query: 452 AEDKAVEHKEILDQLESLKLE----NRHLSEMVMKLELGLHEC---SLPVSPLGSIATRF 504
++ + L E LE +R L L+ L C S + I
Sbjct: 1966 LQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGE 2025
Query: 505 LEEEELRSHHILERLDAHI----EELKRESEK 532
+++++LR +++L + EEL+ + E+
Sbjct: 2026 IQDQDLRYQEDVQQLQQALAQRDEELRHQQER 2057
Score = 74.7 bits (182), Expect = 2e-13
Identities = 127/564 (22%), Positives = 244/564 (43%), Gaps = 83/564 (14%)
Query: 22 EAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQ 81
E L+E +++ + A ++ E AL E+E SL L T KE+ QQ
Sbjct: 888 EMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ 947
Query: 82 VEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIER 141
+ E+++Q+M + Q+LK+ E IL+ ++ Q RE + + HR+D + ++
Sbjct: 948 L---ERLRQDMKV---QKLKE-QETTGILQTQLQEAQ----RELKEAARQHRDDLAALQE 996
Query: 142 LTAKIEEFRQKSLDWEKQ-RLIYQQQVSSLEAQRKALAE-QSEIIQAQLVNRKQK-LESV 198
++ + Q +D +KQ + Q V+ ++QR E Q ++ + Q NR QK LE
Sbjct: 997 ESSSL---LQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELERE 1053
Query: 199 ELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVG------TSMTVLQEQQQKE 252
+ S + +L + + E+ L + + G M +L+++ +++
Sbjct: 1054 KASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEK 1113
Query: 253 EK--LRESEKLLEALQEE---KRELKAALQSQENLIHEARIQKEKLQEKVKATNTQH--- 304
E L + +LLE L+ +++L+A+L +QE + +++ + +++A +
Sbjct: 1114 EADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPG 1173
Query: 305 -----------AVEAIRPREESLAEKKYTSQGQGD-LDSVLSQLNFTHTSEDLLQAEVTC 352
A++ S+ E + G GD SV + + L +
Sbjct: 1174 NQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLL 1233
Query: 353 LEGSLESVSATCKQLSQEL-------------MEKYEE-LKRMEAHNNEYKAEIKKLKEQ 398
S E+V++ +L Q+L ++K EE L EA ++ E++ L+ Q
Sbjct: 1234 TALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQ 1293
Query: 399 ILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRL-RAEMQKAEDKAV 457
+ Q ++ S EG + + ELH+ T+AS ++ RL RAE+Q+ E +
Sbjct: 1294 LSQNQEE-KSKWEGKQNSLESELMELHE---TMAS-------LQSRLRRAELQRMEAQG- 1341
Query: 458 EHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILE 517
+ E L+ +L+ V L+ + E S G + EE+LR+
Sbjct: 1342 -------ERELLQAAKENLTAQVEHLQAAVVEARAQASAAGIL------EEDLRTARSAL 1388
Query: 518 RLDAHIEELKRESEKTVRQFTALK 541
+L E +RE + +++ LK
Sbjct: 1389 KLKNEEVESERERAQALQEQGELK 1412
Score = 71.2 bits (173), Expect = 2e-12
Identities = 115/540 (21%), Positives = 221/540 (40%), Gaps = 74/540 (13%)
Query: 46 RTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKI---KQEMTMEYKQELKK 102
+T LE R QEL L+SQ D+ E L +V E + Q+ +Y++ +K
Sbjct: 252 KTQELEKEAHERSQELIQLKSQGDLEKAE---LQDRVTELSALLTQSQKQNEDYEKMIKA 308
Query: 103 LHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEF------------- 149
L E + IL+ ++ +L M ++N +E++ ++++ I +
Sbjct: 309 LRETVEILETNHTEL----MEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSG 364
Query: 150 RQKSLDWEK---QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQ--- 203
+ SL+ + + YQ +L R L + + +Q E+V L Q
Sbjct: 365 HENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHD 424
Query: 204 ---SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEK 260
E + L +L++ E + L + DL G ++ +E++ ++ E +
Sbjct: 425 QWEEEGKALRQRLQKLTG-------ERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQ 477
Query: 261 LLEALQEEK---RELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLA 317
LE L++E R + LQ Q + A+ QKE+ QE++ E R +E +
Sbjct: 478 QLEVLEQEAWRLRRVNVELQLQGD---SAQGQKEEQQEELHLA----VRERERLQEMLMG 530
Query: 318 EKKYTSQGQGDLDSVLSQLNFTHTSEDLL---QAEVTC----LEGSLESVSATCKQLSQE 370
+ S+ +L ++ L +H +LL Q EVT E S+ +S++ L E
Sbjct: 531 LEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTE 590
Query: 371 LMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDIT 430
+ + ++ A N + L +Q+LQ E+ S +ME + + Q D+
Sbjct: 591 VADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCS--RMEAAEQARNALQVDLA 648
Query: 431 IASTKGSSS-DMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHE 489
A + + + L A++QKAE+ E + L ++ K E+ KL H+
Sbjct: 649 EAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEK------EEIQKKLSESRHQ 702
Query: 490 CSLPVSPLGSIATRFLEEEELRSHHILER---------LDAHIEELKRESEKTVRQFTAL 540
+ L + +EE+ + + E+ L+ ++ ++R+ + Q L
Sbjct: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Score = 53.1 bits (126), Expect = 6e-07
Identities = 110/543 (20%), Positives = 207/543 (38%), Gaps = 74/543 (13%)
Query: 42 EWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELK 101
E E R L+ IR+QEL +LR + E L Q+E + +E ++ +
Sbjct: 1063 EKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEA 1122
Query: 102 KLHEELCILKRSYEKLQKK---QMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWEK 158
+L EEL + ++L+ Q + R S++E L A+ + Q +
Sbjct: 1123 QLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182
Query: 159 QRLI--YQQQVSSLEAQRKALA------------EQSEIIQAQLVNRKQKLESVELSSQS 204
L QQ + S+ R L+ E + L R L ++ + +
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
Query: 205 EIQH-LSSKLERANDTICANELEIERLTMRVNDL------VGTSMTVLQEQ-QQKEEKLR 256
H L L + T ++++L R+ D V T + LQ Q Q +E+
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS 1302
Query: 257 ESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESL 316
+ E +L+ E EL + S ++ + A +Q+ + Q + + Q A E + + E L
Sbjct: 1303 KWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELL--QAAKENLTAQVEHL 1360
Query: 317 AEKKYTSQGQGDLDSVLSQ----------LNFTHTSEDLLQAEVTCLEGSLESVSATCKQ 366
++ Q +L + L + +A+ +G L+ Q
Sbjct: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
Query: 367 -----LSQELMEKYEE-------LKRMEAHNNEYKAEIK------KLKEQILQGEQSYSS 408
L+Q L E+ EE ++ +E KA ++ K + Q + +Q
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQ 1480
Query: 409 ALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLES 468
LE + + HL + +R+ + + ++EK + E + +E ++ +ES
Sbjct: 1481 ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIES 1540
Query: 469 LKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKR 528
+ + + L + ++ LE LE EE +HH +E I+EL+
Sbjct: 1541 QRGQVQDLKKQLVTLE-----------------CLALELEE--NHHKMECQQKLIKELEG 1581
Query: 529 ESE 531
+ E
Sbjct: 1582 QRE 1584
Score = 50.4 bits (119), Expect = 4e-06
Identities = 76/423 (17%), Positives = 173/423 (40%), Gaps = 46/423 (10%)
Query: 18 LTSCEAELQELMKQIDIM---VAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKE 74
L +C+A ++L + + I + + ++ L+ L R++EL+ + + + K
Sbjct: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064
Query: 75 VGMLHQQ--VEEHEKIKQEMTMEYKQELKKLHE-----ELCILKRSYEKLQKKQMREFRG 127
+ Q+ ++E + + QE E E++ LH+ +L + ++ E L+ ++ ++ R
Sbjct: 2065 LAQRVQENMIQEKQNLGQEREEE---EIRGLHQSVRELQLTLAQKEQEILELRETQQ-RN 2120
Query: 128 NTK----NHR----EDRS------------EIERLTAKIEEFRQKSLDWEKQRLIYQQQV 167
N + +H+ E++S E+ERL A + + + ++W ++ +
Sbjct: 2121 NLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSL 2180
Query: 168 SSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEI 227
+ +A +L E + +QA ++ R E L + E+ + + ER + + E+
Sbjct: 2181 AQTKASVSSLQEVAMFLQASVLERDS--EQQRLQDELELTRRALEKERLHSPGATSTAEL 2238
Query: 228 ---ERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIH 284
+++ ++ G + +K+ + E L +A+ + + ++ LQ +
Sbjct: 2239 GSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEID-RSRLQRHNVQLR 2297
Query: 285 EARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSED 344
Q E+ + K+K + A ++ A G+G +S +
Sbjct: 2298 STLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVV 2357
Query: 345 LLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKR------MEAHNNEYKAEIKKLKEQ 398
LLQA++T + Q S+EL + L +AE ++L E
Sbjct: 2358 LLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDES 2417
Query: 399 ILQ 401
+ Q
Sbjct: 2418 LTQ 2420
Score = 45.4 bits (106), Expect = 1e-04
Identities = 86/461 (18%), Positives = 190/461 (41%), Gaps = 76/461 (16%)
Query: 16 GFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALE-------TCLKIREQELKSLRSQL 68
G L + E ++ + + A + E E T AL+ LK R+QEL++LR++
Sbjct: 1890 GDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAES 1949
Query: 69 DVT-HKE-------------VGMLH---QQVEEHEKIKQEMTMEYKQELKKLHEELCILK 111
+ H+E +G H Q E+H + E++ + L L +
Sbjct: 1950 QSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQ 2009
Query: 112 ---RSYEKLQKKQMREFRGNTKNHREDRSEIER-LTAKIEEFR----------------- 150
R E+ + Q E + ++ED ++++ L + EE R
Sbjct: 2010 AHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV 2069
Query: 151 QKSLDWEKQRLIYQQQVSSLEAQRKALAE--------QSEIIQAQLVNRKQKLESVELSS 202
Q+++ EKQ L +++ + +++ E + EI++ + ++ LE++ S
Sbjct: 2070 QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSH 2129
Query: 203 Q-SEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKL 261
+ S ++ S KL+ + + E+ERL + + ++ Q L +++
Sbjct: 2130 KTSPMEEQSLKLDSLEPRL---QRELERLQAALRQTEAREIEWREKAQDLALSLAQTKAS 2186
Query: 262 LEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIR-PREESLAEKK 320
+ +LQE L+A++ +++ ++++LQ++++ T E + P S AE
Sbjct: 2187 VSSLQEVAMFLQASVLERDS-------EQQRLQDELELTRRALEKERLHSPGATSTAELG 2239
Query: 321 YTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKR 380
+ L V ++AE + +S + L Q + + R
Sbjct: 2240 SRGEQGVQLGEVSG-----------VEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSR 2288
Query: 381 MEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLT 421
++ HN + ++ +++++ + + ++ A + +EIS T
Sbjct: 2289 LQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKAT 2329
Score = 37.0 bits (84), Expect = 0.046
Identities = 71/341 (20%), Positives = 137/341 (40%), Gaps = 32/341 (9%)
Query: 157 EKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSSKLERA 216
E+Q L QQQ++ +A + S+ Q + +KL++ L +S Q L +LE
Sbjct: 21 EEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEAT 80
Query: 217 NDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELKAAL 276
I +E + + L+E+QQ+ E L E L E+ + AL
Sbjct: 81 GGPIPQRWENVEEPNL------DELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKAL 134
Query: 277 QSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQL 336
+ + + + + ++++ +Q +E +E K Y G L S+ ++
Sbjct: 135 RED---VEKLTVDWSRARDELMRKESQWQME-----QEFF--KGYLKGEHGRLLSLWREV 184
Query: 337 -----NF----THTSEDL--LQAEVTCLEGSLES--VSATCKQLSQELMEKYEELKRMEA 383
+F + T DL L+AE L GSL + + T S+E R A
Sbjct: 185 VTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPA 244
Query: 384 HNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEK 443
A+ ++L+++ + Q +E + L + + + ++ + D EK
Sbjct: 245 QLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEK 304
Query: 444 RLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLE 484
++A + E H E+++ SL +R+ E + L+
Sbjct: 305 MIKALRETVEILETNHTELMEHEASL---SRNAQEEKLSLQ 342
Score = 33.1 bits (74), Expect = 0.66
Identities = 67/338 (19%), Positives = 125/338 (36%), Gaps = 50/338 (14%)
Query: 103 LHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFR------QKSLD- 155
L E++ L++ + Q R+ + + + + + + +L AK+ ++R +K L+
Sbjct: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA 79
Query: 156 --------WEK-QRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEI 206
WE + + + LE +++ +E + QL +K + V + + ++
Sbjct: 80 TGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAE-VNTQLRLHMEKADVVNKALREDV 138
Query: 207 QHLSSKLERANDTICANE-----------------------LEIERLTMRVNDLVGTSMT 243
+ L+ RA D + E L E +T R + L S T
Sbjct: 139 EKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSAT 198
Query: 244 VLQEQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQ 303
+ K E +R S LL L QS+E +E Q + TQ
Sbjct: 199 DRDLMELKAEHVRLSGSLLTCC----LRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQ 254
Query: 304 HAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSAT 363
+ R + L + K QGDL+ Q T S L Q++ E +
Sbjct: 255 ELEKEAHERSQELIQLK----SQGDLEKAELQDRVTELSALLTQSQKQ--NEDYEKMIKA 308
Query: 364 CKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQ 401
++ + L + EL EA + E K +Q+++
Sbjct: 309 LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIK 346
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 88.2 bits (217), Expect = 2e-17
Identities = 105/463 (22%), Positives = 211/463 (45%), Gaps = 49/463 (10%)
Query: 83 EEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQ-----MREFRGNTKNHREDRS 137
E++EKI Q + EYK+E+ +++ +L + + K + E + N E+++
Sbjct: 245 EDYEKI-QHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKT 303
Query: 138 EI--ERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL 195
++ E L IE+ + + E ++ Q+ VS+ +KAL E +I + ++
Sbjct: 304 KLQSENLKQSIEKQHHLTKELEDIKVSLQRSVST----QKALEEDLQIATKTICQLTEEK 359
Query: 196 ES-VELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEK 254
E+ +E S+++ H S + T+C+ E + R+ + E Q+K +
Sbjct: 360 ETQMEESNKARAAH-SFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSE 418
Query: 255 LRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREE 314
L E KL + E ELK L +E L++E + Q EK+ E++K T Q + ++ RE+
Sbjct: 419 LEEMTKLTNNKEVELEELKKVLGEKETLLYENK-QFEKIAEELKGTE-QELIGLLQAREK 476
Query: 315 SLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLES-------VSATCKQL 367
+ + + QL TSE EV L+ LE+ +++ C +L
Sbjct: 477 EVHDLEI-------------QLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKL 523
Query: 368 SQELMEKYEELKRMEAHNNEYKAEI---KKLKEQILQGEQSYSSALEGMKMEISHLTQEL 424
S E E +E M + +I KK +E++L+ ++ ++ E+ ++ +EL
Sbjct: 524 SLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREEL 583
Query: 425 HQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK----LENRHLSE-- 478
Q+ + S + LR +++ ++K +E E+ + ++LK E++ L+
Sbjct: 584 KQKRDEVKCKLDKSEENCNNLRKQVEN-KNKYIE--ELQQENKALKKKGTAESKQLNVYE 640
Query: 479 -MVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLD 520
V KLEL L + + +E++++ ++LE ++
Sbjct: 641 IKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVE 683
Score = 63.5 bits (153), Expect = 5e-10
Identities = 120/549 (21%), Positives = 240/549 (43%), Gaps = 65/549 (11%)
Query: 24 ELQELMKQIDIM---VAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQ 80
E+ + KQ+ ++ + K+++ + T LE Q + + Q + + + H
Sbjct: 260 EINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHH 319
Query: 81 QVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKK---QMREFRGNTKNHREDRS 137
+E E IK + + K L E+L I ++ +L ++ QM E H +
Sbjct: 320 LTKELEDIKVSLQRSVSTQ-KALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVT 378
Query: 138 EIERLTAKIEEFRQKSLDWEKQRLIY---QQQVSSLEAQRKALAEQSEIIQAQLVNRKQ- 193
E E +EE L E+QRL Q ++ ++E Q+K+ +E E+ +L N K+
Sbjct: 379 EFETTVCSLEEL----LRTEQQRLEKNEDQLKILTMELQKKS-SELEEM--TKLTNNKEV 431
Query: 194 KLESVE--LSSQSEIQHLSSKLERANDTICANELEIERLTM----RVNDLVG--TSMTVL 245
+LE ++ L + + + + + E+ + + E E+ L V+DL T++T
Sbjct: 432 ELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTS 491
Query: 246 QEQQQKE----------EKLRESE------KLL---EALQEEKRELKAALQSQENLIHEA 286
++ KE EKL+ +E KL + L +E ++ L++Q+ I+
Sbjct: 492 EQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNN 551
Query: 287 RIQKEKLQ---EKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSE 343
+ Q+E++ E ++ T TQ E REE L +K+ D V +L+ + +
Sbjct: 552 KKQEERMLKQIENLQETETQLRNELEYVREE-LKQKR---------DEVKCKLDKSEENC 601
Query: 344 DLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGE 403
+ L+ +V +E + K L ++ + ++L E N+ + E++ K++ +
Sbjct: 602 NNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEIT 661
Query: 404 QSYSSALEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEIL 463
+Y +E K+ +L +E+ + + +++KR + ++ + +HK
Sbjct: 662 DTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQY 721
Query: 464 DQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDAHI 523
D++ +E R SE+ + + SL S I L+ E L LE
Sbjct: 722 DKI----IEERD-SELGLYKSKEQEQSSLRASL--EIELSNLKAELLSVKKQLEIEREEK 774
Query: 524 EELKRESEK 532
E+LKRE+++
Sbjct: 775 EKLKREAKE 783
Score = 49.3 bits (116), Expect = 9e-06
Identities = 56/257 (21%), Positives = 125/257 (48%), Gaps = 25/257 (9%)
Query: 60 ELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQK 119
ELK+ + ++ K+ + +Q+E QE + + EL+ + EEL KR K +
Sbjct: 540 ELKNQQEDINNNKKQEERMLKQIEN----LQETETQLRNELEYVREELK-QKRDEVKCKL 594
Query: 120 KQMREFRGNTKNHREDRSE-IERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQ----R 174
+ E N + E++++ IE L + + ++K KQ +Y+ +V+ LE + +
Sbjct: 595 DKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAK 654
Query: 175 KALAEQSEIIQAQLVNRKQKLESV--ELSSQSEIQHLSSKLERANDTICANELE-----I 227
+ E ++ Q ++ ++K E++ E+ I + KL++ D C +++ +
Sbjct: 655 QKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALM 714
Query: 228 ERLTMRVNDLV---GTSMTVLQEQQQKEEKLRESEKL-LEALQEE----KRELKAALQSQ 279
E+ + + ++ + + + + ++Q++ LR S ++ L L+ E K++L+ + +
Sbjct: 715 EKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEK 774
Query: 280 ENLIHEARIQKEKLQEK 296
E L EA+ L+EK
Sbjct: 775 EKLKREAKENTATLKEK 791
Score = 46.2 bits (108), Expect = 8e-05
Identities = 59/244 (24%), Positives = 114/244 (46%), Gaps = 33/244 (13%)
Query: 247 EQQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATN-TQHA 305
E +QKE KL+E+ K++EA ++ +EL+ + +L E IQ+ K + +K N T+H
Sbjct: 126 ELRQKESKLQENRKIIEAQRKAIQELQFG-NEKVSLKLEEGIQENK--DLIKENNATRHL 182
Query: 306 VEAIRPREESLAE--KKY------TSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLE--- 354
++ AE KKY T Q DL++ + ++ T E +QAE + LE
Sbjct: 183 CNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKM-ITAFEELRVQAENSRLEMHF 241
Query: 355 ---GSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKL-------KEQILQGEQ 404
E + ++ +E+ +K +++ + E + ++K L ++++ Q E+
Sbjct: 242 KLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEE 301
Query: 405 SYSSALEGMKMEIS---HLTQELHQRDI----TIASTKGSSSDMEKRLRAEMQKAEDKAV 457
E +K I HLT+EL + ++++ K D++ + Q E+K
Sbjct: 302 KTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKET 361
Query: 458 EHKE 461
+ +E
Sbjct: 362 QMEE 365
Score = 41.6 bits (96), Expect = 0.002
Identities = 55/257 (21%), Positives = 111/257 (43%), Gaps = 34/257 (13%)
Query: 25 LQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE 84
LQE Q+ + + + E + + ++ L E+ +LR Q++ +K + L Q E
Sbjct: 565 LQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQ---E 621
Query: 85 HEKIKQEMTMEYKQ------ELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHREDRSE 138
++ +K++ T E KQ ++ KL EL K+ + ++ +E + E
Sbjct: 622 NKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEE 681
Query: 139 IERLTAKIEEF--RQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLE 196
+E+ +E QK +D Q I A+ AL E+ + +++ +
Sbjct: 682 VEKAKVIADEAVKLQKEIDKRCQHKI---------AEMVALMEKHKHQYDKIIEERDSEL 732
Query: 197 SVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLR 256
+ S + E L + LE I + L+ E L+++ L+ +++++EKL+
Sbjct: 733 GLYKSKEQEQSSLRASLE-----IELSNLKAELLSVKKQ---------LEIEREEKEKLK 778
Query: 257 ESEKLLEALQEEKRELK 273
K A +EK++ K
Sbjct: 779 REAKENTATLKEKKDKK 795
Score = 30.0 bits (66), Expect = 5.6
Identities = 31/180 (17%), Positives = 82/180 (45%), Gaps = 8/180 (4%)
Query: 313 EESLAEKKYTSQGQG-DLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQEL 371
E A+ + G+ D D L ++NF E + ++ EG +S + LS+
Sbjct: 47 EFPFAKTNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGLSRVY 106
Query: 372 MEKYEELKRMEAHNNEYKAEIK----KLKE--QILQGEQSYSSALEGMKMEISHLTQELH 425
+ Y+E ++++ +AE++ KL+E +I++ ++ L+ ++S +E
Sbjct: 107 SKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGI 166
Query: 426 QRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLE-NRHLSEMVMKLE 484
Q + + ++ + L+ ++ +K +++ ++ + ++ N ++ +M+ E
Sbjct: 167 QENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFE 226
>gi|42794779 myosin 18A isoform b [Homo sapiens]
Length = 2039
Score = 87.4 bits (215), Expect = 3e-17
Identities = 117/485 (24%), Positives = 225/485 (46%), Gaps = 64/485 (13%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
+ S EAELQ++ Q +S+ E ++ L+ E ++K +LD + M
Sbjct: 1516 VVSLEAELQDISSQ--------ESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQM 1567
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQM-----REFRGNTKNH 132
L Q E + M + +E++ EE+ ++S +K + KQM E+ K
Sbjct: 1568 LEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQK-KLKQMEVQLEEEYEDKQKVL 1626
Query: 133 REDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK 192
RE R +L ++ ++ + EK ++ + KAL ++++ L N
Sbjct: 1627 REKRELEGKLATLSDQVNRRDFESEK-------RLRKDLKRTKALLADAQLMLDHLKN-- 1677
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTIC-------ANELEIERLTMRVNDLVGTSMTVL 245
S+ EI L ++LE + T A E+EIE L ++++D + + T L
Sbjct: 1678 ------SAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDD-IAKAKTAL 1730
Query: 246 QEQQQK-EEKLRESEKLLEALQEEKREL----KAAL-QSQENL---------IHEARIQK 290
+EQ + + + E + LE QE+ EL KAA+ Q+ +L + EA +K
Sbjct: 1731 EEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEK 1790
Query: 291 EKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEV 350
++LQEK++A +Q VE + E+S+ +K S+ + + + ++L F T L++
Sbjct: 1791 QELQEKLQALQSQ--VEFL---EQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLA 1845
Query: 351 TCLEGSLESVSATCKQ-LSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSA 409
+ L+ ++E ++ Q ++ E EK E+ KR++ + K E+ +L + + E S
Sbjct: 1846 SRLKENMEKLTEERDQRIAAENREK-EQNKRLQRQLRDTKEEMGELARK--EAEASRKKH 1902
Query: 410 LEGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESL 469
M +E + Q D+ +A + D++ + EM+ E++ + + E ++S
Sbjct: 1903 ELEMDLESLEAANQSLQADLKLAFKR--IGDLQAAIEDEMESDENEDLINSEGDSDVDS- 1959
Query: 470 KLENR 474
+LE+R
Sbjct: 1960 ELEDR 1964
Score = 80.5 bits (197), Expect = 4e-15
Identities = 108/509 (21%), Positives = 219/509 (43%), Gaps = 56/509 (11%)
Query: 51 ETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCIL 110
E ++ +++E++ LRS+L+ KE L + E E+T E E +L
Sbjct: 1253 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLL 1312
Query: 111 -KRSYEKLQ-KKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWE--------KQR 160
+ E+L+ +K+M+E + ++ +E + R ++ E + R
Sbjct: 1313 DAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWR 1372
Query: 161 LIYQQQVSSLEAQRKALAEQSE-IIQAQLVNRKQ------KLESVELSSQSEIQHLSSKL 213
L Y++ V ++ +K L ++ E ++ + N++Q L++ SQ +Q L K
Sbjct: 1373 LKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKC 1432
Query: 214 ERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELK 273
+R + +L +E +R ++L E Q E+ + + E LQ EK
Sbjct: 1433 QRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREK---- 1488
Query: 274 AALQSQENLIHEARIQKEKLQEK-VKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSV 332
+ L+ EA K++L+EK + V ++ + ++ ++ S+ + L V
Sbjct: 1489 ------DMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQE--SKDEASLAKV 1540
Query: 333 LSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRM-EAHNNEYKAE 391
QL L+A+V E L+ + T + L Q + E++RM + H+ E ++
Sbjct: 1541 KKQLRD-------LEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1593
Query: 392 -----------IKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIA-STKGSSS 439
KKLK+ +Q E+ Y K ++ +EL + T++
Sbjct: 1594 DEEVEEARQSCQKKLKQMEVQLEEEYED-----KQKVLREKRELEGKLATLSDQVNRRDF 1648
Query: 440 DMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGS 499
+ EKRLR ++++ + + + +LD L++ R ++++ +LE C+ V +
Sbjct: 1649 ESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKA 1708
Query: 500 IATRFLEEEELRSHHILERLDAHIEELKR 528
+ +E+ L+ I + A E+L R
Sbjct: 1709 MEVE-IEDLHLQIDDIAKAKTALEEQLSR 1736
Score = 73.2 bits (178), Expect = 6e-13
Identities = 102/529 (19%), Positives = 231/529 (43%), Gaps = 102/529 (19%)
Query: 51 ETCLKIR-EQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQ--------------EMTME 95
ET ++R E+E+K L++Q D K++ ++ +V E I+ E ++
Sbjct: 1315 ETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLK 1374
Query: 96 YKQELKKLHEELCILKRSYE-KLQ-----KKQMREFRGNTKNHRED--------RSEIER 141
Y++ ++++ L++ +E KL+ K+Q+ G+ + E+ + + +R
Sbjct: 1375 YERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQR 1434
Query: 142 LTAKIEEFRQ-------KSLDWEKQRLIYQQQVSSL-------EAQRKALAEQSEIIQAQ 187
LTA++++ + ++ + EK++ + ++S + QR+ L + +++ A+
Sbjct: 1435 LTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAE 1494
Query: 188 LVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQE 247
+ KQ+LE +++I T +V L + +
Sbjct: 1495 AFSLKQQLEE-------------------------KDMDIAGFTQKVVSLEAELQDISSQ 1529
Query: 248 QQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVE 307
+ + E L + +K L L+ + ++ + L Q I K +L+ +++ H+ E
Sbjct: 1530 ESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKE 1589
Query: 308 AIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQL 367
+ R+E + E + + Q + L + QL + + + E LEG L ++S +
Sbjct: 1590 -MESRDEEVEEARQSCQKK--LKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRR 1646
Query: 368 SQELMEKY-EELKRMEA-------------HNNEYKAEIKKLKEQILQGEQSYSSALEGM 413
E ++ ++LKR +A ++ K EI +LK Q+ + E + ++A++
Sbjct: 1647 DFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKAR 1706
Query: 414 K-MEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLE 472
K ME+ ++LH + IA K + + RL+ E + +++ E +E
Sbjct: 1707 KAMEVE--IEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQE----------- 1753
Query: 473 NRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDA 521
++E++ K + + + S ++ + + + LEE + E+L A
Sbjct: 1754 --DMNELMKKHKAAVAQASRDLAQINDLQAQ-LEEANKEKQELQEKLQA 1799
>gi|28416946 myosin 18A isoform a [Homo sapiens]
Length = 2054
Score = 86.3 bits (212), Expect = 7e-17
Identities = 113/494 (22%), Positives = 227/494 (45%), Gaps = 76/494 (15%)
Query: 18 LTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGM 77
+ S EAELQ++ Q +S+ E ++ L+ E ++K +LD + M
Sbjct: 1516 VVSLEAELQDISSQ--------ESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQM 1567
Query: 78 LHQQVEEHEKIKQEMTMEYKQELKKLHEELCILKRSYEKLQKKQM-----REFRGNTKNH 132
L Q E + M + +E++ EE+ ++S +K + KQM E+ K
Sbjct: 1568 LEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQK-KLKQMEVQLEEEYEDKQKVL 1626
Query: 133 REDRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRK 192
RE R +L ++ ++ + EK ++ + KAL ++++ L N
Sbjct: 1627 REKRELEGKLATLSDQVNRRDFESEK-------RLRKDLKRTKALLADAQLMLDHLKN-- 1677
Query: 193 QKLESVELSSQSEIQHLSSKLERANDTIC-------ANELEIERLTMRVNDLVGTSMTVL 245
S+ EI L ++LE + T A E+EIE L ++++D + + T L
Sbjct: 1678 ------SAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDD-IAKAKTAL 1730
Query: 246 QEQQQK-EEKLRESEKLLEALQEEKREL----KAAL-QSQENL---------IHEARIQK 290
+EQ + + + E + LE QE+ EL KAA+ Q+ +L + EA +K
Sbjct: 1731 EEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEK 1790
Query: 291 EKLQEKVKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEV 350
++LQEK++A +Q VE + E+S+ +K S+ + + + ++L F T
Sbjct: 1791 QELQEKLQALQSQ--VEFL---EQSMVDKSLVSRQEAKIRELETRLEFERTQVK------ 1839
Query: 351 TCLEGSLESVSATCKQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSAL 410
LES+++ K+ ++L E+ ++ R+ A N E K + K+L+ Q+ ++
Sbjct: 1840 -----RLESLASRLKENMEKLTEERDQ--RIAAENRE-KEQNKRLQRQLRDTKEEMGE-- 1889
Query: 411 EGMKMEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLK 470
+ + + +++ H+ ++ + S + ++ ++ L+ ++ D ++ ++ E+
Sbjct: 1890 --LARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENED 1947
Query: 471 LENRHLSEMVMKLE 484
L N L +MV K +
Sbjct: 1948 LIN-SLQDMVTKYQ 1960
Score = 80.5 bits (197), Expect = 4e-15
Identities = 108/509 (21%), Positives = 219/509 (43%), Gaps = 56/509 (11%)
Query: 51 ETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQELKKLHEELCIL 110
E ++ +++E++ LRS+L+ KE L + E E+T E E +L
Sbjct: 1253 EEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLL 1312
Query: 111 -KRSYEKLQ-KKQMREFRGNTKNHREDRSEIERLTAKIEEFRQKSLDWE--------KQR 160
+ E+L+ +K+M+E + ++ +E + R ++ E + R
Sbjct: 1313 DAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWR 1372
Query: 161 LIYQQQVSSLEAQRKALAEQSE-IIQAQLVNRKQ------KLESVELSSQSEIQHLSSKL 213
L Y++ V ++ +K L ++ E ++ + N++Q L++ SQ +Q L K
Sbjct: 1373 LKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKC 1432
Query: 214 ERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRELK 273
+R + +L +E +R ++L E Q E+ + + E LQ EK
Sbjct: 1433 QRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREK---- 1488
Query: 274 AALQSQENLIHEARIQKEKLQEK-VKATNTQHAVEAIRPREESLAEKKYTSQGQGDLDSV 332
+ L+ EA K++L+EK + V ++ + ++ ++ S+ + L V
Sbjct: 1489 ------DMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQE--SKDEASLAKV 1540
Query: 333 LSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQELMEKYEELKRM-EAHNNEYKAE 391
QL L+A+V E L+ + T + L Q + E++RM + H+ E ++
Sbjct: 1541 KKQLRD-------LEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESR 1593
Query: 392 -----------IKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIA-STKGSSS 439
KKLK+ +Q E+ Y K ++ +EL + T++
Sbjct: 1594 DEEVEEARQSCQKKLKQMEVQLEEEYED-----KQKVLREKRELEGKLATLSDQVNRRDF 1648
Query: 440 DMEKRLRAEMQKAEDKAVEHKEILDQLESLKLENRHLSEMVMKLELGLHECSLPVSPLGS 499
+ EKRLR ++++ + + + +LD L++ R ++++ +LE C+ V +
Sbjct: 1649 ESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKA 1708
Query: 500 IATRFLEEEELRSHHILERLDAHIEELKR 528
+ +E+ L+ I + A E+L R
Sbjct: 1709 MEVE-IEDLHLQIDDIAKAKTALEEQLSR 1736
Score = 73.2 bits (178), Expect = 6e-13
Identities = 102/529 (19%), Positives = 231/529 (43%), Gaps = 102/529 (19%)
Query: 51 ETCLKIR-EQELKSLRSQLDVTHKEVGMLHQQVEEHEKIKQ--------------EMTME 95
ET ++R E+E+K L++Q D K++ ++ +V E I+ E ++
Sbjct: 1315 ETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLK 1374
Query: 96 YKQELKKLHEELCILKRSYE-KLQ-----KKQMREFRGNTKNHRED--------RSEIER 141
Y++ ++++ L++ +E KL+ K+Q+ G+ + E+ + + +R
Sbjct: 1375 YERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQR 1434
Query: 142 LTAKIEEFRQ-------KSLDWEKQRLIYQQQVSSL-------EAQRKALAEQSEIIQAQ 187
LTA++++ + ++ + EK++ + ++S + QR+ L + +++ A+
Sbjct: 1435 LTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAE 1494
Query: 188 LVNRKQKLESVELSSQSEIQHLSSKLERANDTICANELEIERLTMRVNDLVGTSMTVLQE 247
+ KQ+LE +++I T +V L + +
Sbjct: 1495 AFSLKQQLEE-------------------------KDMDIAGFTQKVVSLEAELQDISSQ 1529
Query: 248 QQQKEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVE 307
+ + E L + +K L L+ + ++ + L Q I K +L+ +++ H+ E
Sbjct: 1530 ESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKE 1589
Query: 308 AIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQL 367
+ R+E + E + + Q + L + QL + + + E LEG L ++S +
Sbjct: 1590 -MESRDEEVEEARQSCQKK--LKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRR 1646
Query: 368 SQELMEKY-EELKRMEA-------------HNNEYKAEIKKLKEQILQGEQSYSSALEGM 413
E ++ ++LKR +A ++ K EI +LK Q+ + E + ++A++
Sbjct: 1647 DFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKAR 1706
Query: 414 K-MEISHLTQELHQRDITIASTKGSSSDMEKRLRAEMQKAEDKAVEHKEILDQLESLKLE 472
K ME+ ++LH + IA K + + RL+ E + +++ E +E
Sbjct: 1707 KAMEVE--IEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQE----------- 1753
Query: 473 NRHLSEMVMKLELGLHECSLPVSPLGSIATRFLEEEELRSHHILERLDA 521
++E++ K + + + S ++ + + + LEE + E+L A
Sbjct: 1754 --DMNELMKKHKAAVAQASRDLAQINDLQAQ-LEEANKEKQELQEKLQA 1799
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 85.5 bits (210), Expect = 1e-16
Identities = 98/453 (21%), Positives = 205/453 (45%), Gaps = 48/453 (10%)
Query: 39 KKSEWEGRTHALETCL-----KIREQELKSLRSQLDVTHKEVGMLHQQV----------- 82
K EWE + E + KIREQE K R + + KE M Q+
Sbjct: 308 KIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 83 ------EEHEKIK--QEMTMEYKQELKKLHEELCILKRSYEKLQKKQMREFRGNTKNHRE 134
E+ EK++ +EM E ++++++L E++ ++ E+ +K+Q E + +E
Sbjct: 368 QEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE 427
Query: 135 DRSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQK 194
+++ R KI E +K + EK+ +Q + Q K E+ Q ++ +++K
Sbjct: 428 QEAKMWRQEEKIREQEEKIREQEKK---MWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 484
Query: 195 L-ESVELSSQSEIQH-LSSKLERANDTICANELEIERLTMRV---NDLVGTSMTVLQEQQ 249
+ E E+ Q E H K+ + + + E +I ++ + + ++EQ+
Sbjct: 485 IHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQE 544
Query: 250 Q---KEEKLRESEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVK--ATNTQH 304
+ +EEK+ E EK+ E +E+++E + + QE I E + + +EK++ Q
Sbjct: 545 EMWREEEKMHEQEKIWE--EEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602
Query: 305 AVEAIRPREESLAEKKYTSQGQGDLDSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATC 364
E + +EE + E++ Q Q + + Q E++ Q + E E C
Sbjct: 603 QEEKMWKQEEKIREQEEKIQEQE--EKIREQEEKIREQEEMTQEQE---EKMGEQEEKMC 657
Query: 365 KQLSQELMEKYEELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGM---KMEISHLT 421
+Q +++ E+ E + R E E + +I++ +E+I + E+ E M + ++
Sbjct: 658 EQ-EEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 716
Query: 422 QELHQRDITIASTKGSSSDMEKRLRAEMQKAED 454
+++ +++ + + + E RLR + +K ++
Sbjct: 717 EKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 77.0 bits (188), Expect = 4e-14
Identities = 85/363 (23%), Positives = 165/363 (45%), Gaps = 59/363 (16%)
Query: 2 EALLEGIQNRGHGGGFLTSCEAELQELMKQIDIMVAHKKSEWEGRTHALETCLKIREQEL 61
E + ++ + H + E + QE K I K+ E E + E KIREQE
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEK---IREQEKRQEQEAKMWRQEE--KIREQEE 444
Query: 62 KSLRSQLDVTHKEVGMLHQQVEEHEKIKQEMTMEYKQEL----KKLHEELCI------LK 111
K +R Q K++ +++ E EKI++E + ++E+ +K+HE+ I +
Sbjct: 445 K-IREQ----EKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMH 499
Query: 112 RSYEKLQKKQMREFRGNTKNHRED---RSEIERLTAKIEEFRQKSLDWEKQRLIY----- 163
EK++K++ + +R K ++ R + E++ + E+ R++ W ++ ++
Sbjct: 500 EQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKI 559
Query: 164 ------QQQVSSLEAQRKALAEQSEIIQAQ------LVNRKQKLESVELSSQSEIQHLSS 211
Q+Q + Q + + EQ E + Q ++Q+ E + +I+
Sbjct: 560 WEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEE 619
Query: 212 KLERANDTICANELEI---ERLTMRVNDLVGTSMTVLQEQQQK-----------EEKLRE 257
K++ + I E +I E +T + +G + EQ++K EEK+RE
Sbjct: 620 KIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIRE 679
Query: 258 SEKLLEALQEEKRELKAALQSQENLIHEARIQKEKLQEKVKATNTQHAVEAIRPREESLA 317
EK + +E+ RE + +Q QE + E Q+EK+ E+ + Q E +R +EE +
Sbjct: 680 QEKKIREQEEKIREQEEMMQEQEEKMWE---QEEKMCEQEEKMQEQE--EKMRRQEEKMW 734
Query: 318 EKK 320
E++
Sbjct: 735 EQE 737
Score = 68.9 bits (167), Expect = 1e-11
Identities = 109/527 (20%), Positives = 227/527 (43%), Gaps = 74/527 (14%)
Query: 45 GRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQVEE-------HEKIKQEMTMEYK 97
G H+ E K Q ++LR +L+ + +L Q E + +++ E +
Sbjct: 102 GGCHSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEAR 161
Query: 98 QELKKLHE------ELCILKRSYEKLQKKQMREFRGNTKNHREDRSEIERLTAKIEEFRQ 151
+ +LH+ EL + +KK R TK E+ R T EE ++
Sbjct: 162 DLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKE 221
Query: 152 KSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKLESVELSSQSEIQHLSS 211
K+ +++ + + + S ++ K L + E +A+L+ +Q+L++ E+Q +S+
Sbjct: 222 KNAKLQEKLQLVESEKSEIQLNVKELKRKLE--RAKLLLPQQQLQAEADHLGKELQSVSA 279
Query: 212 KLERANDTICANELEIERLTMRVNDLVGTSMTVLQEQQQKEEKLRESEKLLEALQEEKRE 271
KL+ ++E L R+N QQ+EEK+ E+ ++ +E+ +E
Sbjct: 280 KLQA--------QVEENELWNRLN-------------QQQEEKMWRQEEKIQEWEEKIQE 318
Query: 272 LKAALQSQENLIHE----ARIQKEKLQEKVKATNTQHAV-----EAIRPREESLAEKKYT 322
+ ++ QE I E R Q+E + EK + Q + E +R +EE + EK+
Sbjct: 319 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 378
Query: 323 SQGQGDL-----DSVLSQLNFTHTSEDLLQAEVTCLEGSLESVSATCKQLSQE--LMEKY 375
+ Q ++ + + H E + + E E E + K+ QE + +
Sbjct: 379 MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE--EKIREQEKRQEQEAKMWRQE 436
Query: 376 EELKRMEAHNNEYKAEIKKLKEQILQGEQSYSSALEGMKMEISHLTQELHQRDITIASTK 435
E+++ E E + ++ + +E+I + E+ + E+ +++H+++ I K
Sbjct: 437 EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQE-EIWRQK 495
Query: 436 GSSSDMEKRLRAEMQKA---EDKAVEHKE-ILDQLESLKLENRHLSEM--VMKLELGLHE 489
+ E+++R + +K E+K E +E I +Q E + + + E + + E +HE
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHE 555
Query: 490 CSLPVSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQ 536
+ EEE+ + +++ E+++ + EK RQ
Sbjct: 556 -----------QEKIWEEEKRQEQE--DKMWRQEEKIREQEEKVWRQ 589
Score = 47.8 bits (112), Expect = 3e-05
Identities = 41/184 (22%), Positives = 87/184 (47%), Gaps = 17/184 (9%)
Query: 27 ELMKQIDIMVAHKKSEWEGRTHALETCLKIREQELKSLRSQLDVTHKEVGMLHQQV---E 83
++ +Q + + ++ W E K +EQE K + + + +E + Q+ E
Sbjct: 571 KMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE 630
Query: 84 EHEKIKQ--EMTMEYKQELKKLHEELCILKRSYEKLQK------KQMREFRGNTKNHRED 135
+ EKI++ EMT E ++++ + E++C EK+Q+ +Q + R K RE
Sbjct: 631 QEEKIREQEEMTQEQEEKMGEQEEKMC---EQEEKMQEQEETMWRQEEKIREQEKKIREQ 687
Query: 136 RSEIERLTAKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLVNRKQKL 195
+I ++E +K WE++ + +Q+ ++ Q + + Q E + Q V +Q+
Sbjct: 688 EEKIREQEEMMQEQEEKM--WEQEEKMCEQE-EKMQEQEEKMRRQEEKMWEQEVRLRQQE 744
Query: 196 ESVE 199
E ++
Sbjct: 745 EKMQ 748
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.125 0.323
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,027,734
Number of Sequences: 37866
Number of extensions: 808603
Number of successful extensions: 16797
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 487
Number of HSP's successfully gapped in prelim test: 1214
Number of HSP's that attempted gapping in prelim test: 5746
Number of HSP's gapped (non-prelim): 5578
length of query: 541
length of database: 18,247,518
effective HSP length: 107
effective length of query: 434
effective length of database: 14,195,856
effective search space: 6161001504
effective search space used: 6161001504
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.