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Search of human proteins with 109255234
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|109255234 centrosomal protein 290kDa [Homo sapiens]
(2479 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 4736 0.0
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 270 1e-71
gi|71061468 centromere protein E [Homo sapiens] 265 4e-70
gi|55770834 centromere protein F [Homo sapiens] 243 1e-63
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 243 2e-63
gi|21735548 centrosomal protein 2 [Homo sapiens] 228 6e-59
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 224 8e-58
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 222 4e-57
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 193 2e-48
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 191 1e-47
gi|148746195 trichohyalin [Homo sapiens] 186 3e-46
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 185 5e-46
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 182 4e-45
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 177 1e-43
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 173 2e-42
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 172 4e-42
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 172 4e-42
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 172 4e-42
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 172 4e-42
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 171 8e-42
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 171 8e-42
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 171 8e-42
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 171 8e-42
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 171 8e-42
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 171 8e-42
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 171 8e-42
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 171 8e-42
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 166 3e-40
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 165 5e-40
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 164 8e-40
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 4736 bits (12284), Expect = 0.0
Identities = 2479/2479 (100%), Positives = 2479/2479 (100%)
Query: 1 MPPNINWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMK 60
MPPNINWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMK
Sbjct: 1 MPPNINWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMK 60
Query: 61 MKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQL 120
MKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQL
Sbjct: 61 MKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQL 120
Query: 121 EKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDI 180
EKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDI
Sbjct: 121 EKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDI 180
Query: 181 IDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMR 240
IDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMR
Sbjct: 181 IDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMR 240
Query: 241 KNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDD 300
KNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDD
Sbjct: 241 KNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDD 300
Query: 301 PIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQER 360
PIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQER
Sbjct: 301 PIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQER 360
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT 420
DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT
Sbjct: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT 420
Query: 421 KEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIE 480
KEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIE
Sbjct: 421 KEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIE 480
Query: 481 ILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLK 540
ILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLK
Sbjct: 481 ILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLK 540
Query: 541 EIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLK 600
EIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLK
Sbjct: 541 EIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLK 600
Query: 601 NMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKE 660
NMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKE
Sbjct: 601 NMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKE 660
Query: 661 MQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELR 720
MQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELR
Sbjct: 661 MQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELR 720
Query: 721 ESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQ 780
ESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQ
Sbjct: 721 ESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQ 780
Query: 781 NEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTI 840
NEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTI
Sbjct: 781 NEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTI 840
Query: 841 KEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQY 900
KEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQY
Sbjct: 841 KEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQY 900
Query: 901 TTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLS 960
TTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLS
Sbjct: 901 TTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLS 960
Query: 961 ELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEK 1020
ELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEK
Sbjct: 961 ELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEK 1020
Query: 1021 LHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMY 1080
LHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMY
Sbjct: 1021 LHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMY 1080
Query: 1081 EHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILE 1140
EHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILE
Sbjct: 1081 EHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILE 1140
Query: 1141 LEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLI 1200
LEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLI
Sbjct: 1141 LEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLI 1200
Query: 1201 AKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA 1260
AKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA
Sbjct: 1201 AKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA 1260
Query: 1261 KHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLE 1320
KHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLE
Sbjct: 1261 KHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLE 1320
Query: 1321 MELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIIS 1380
MELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIIS
Sbjct: 1321 MELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIIS 1380
Query: 1381 EYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG 1440
EYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG
Sbjct: 1381 EYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG 1440
Query: 1441 SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK 1500
SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK
Sbjct: 1441 SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK 1500
Query: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ
Sbjct: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
Query: 1561 RLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF 1620
RLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF
Sbjct: 1561 RLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF 1620
Query: 1621 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEV 1680
IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEV
Sbjct: 1621 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEV 1680
Query: 1681 KKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQ 1740
KKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQ
Sbjct: 1681 KKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQ 1740
Query: 1741 QKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLK 1800
QKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLK
Sbjct: 1741 QKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLK 1800
Query: 1801 LKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSG 1860
LKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSG
Sbjct: 1801 LKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSG 1860
Query: 1861 LQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQA 1920
LQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQA
Sbjct: 1861 LQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQA 1920
Query: 1921 KIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRAL 1980
KIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRAL
Sbjct: 1921 KIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRAL 1980
Query: 1981 ESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDT 2040
ESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDT
Sbjct: 1981 ESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDT 2040
Query: 2041 YSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMC 2100
YSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMC
Sbjct: 2041 YSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMC 2100
Query: 2101 EFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTS 2160
EFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTS
Sbjct: 2101 EFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTS 2160
Query: 2161 EKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAA 2220
EKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAA
Sbjct: 2161 EKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAA 2220
Query: 2221 EKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLK 2280
EKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLK
Sbjct: 2221 EKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLK 2280
Query: 2281 ELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRE 2340
ELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRE
Sbjct: 2281 ELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRE 2340
Query: 2341 LQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQ 2400
LQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQ
Sbjct: 2341 LQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQ 2400
Query: 2401 HLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPV 2460
HLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPV
Sbjct: 2401 HLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPV 2460
Query: 2461 AASEEFEDEEESPVNFPIY 2479
AASEEFEDEEESPVNFPIY
Sbjct: 2461 AASEEFEDEEESPVNFPIY 2479
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 270 bits (691), Expect = 1e-71
Identities = 540/2568 (21%), Positives = 1060/2568 (41%), Gaps = 395/2568 (15%)
Query: 113 LRNEICQLEKQLEQKDRELEDMEKE---------------------------------LE 139
L++ I Q + QL+QKD L++ K L
Sbjct: 64 LKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLP 123
Query: 140 KEKKVNEQLALRNEEAENENSKLRRENKRLKKKNE-------QLCQDIIDYQKQIDSQKE 192
E + EQL+ ++ + E ++ + +L++K E QL Q + Q ++ E
Sbjct: 124 TEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEME 183
Query: 193 TLLSRRGEDSDYRSQLSKKNYELIQYLDE---IQTLTEANEKIEVQNQEMRKNLEESVQE 249
+ + + + +S +L Q E Q + E + + E Q + L + V +
Sbjct: 184 EFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQ 243
Query: 250 MEKMTDEYNRMKAIVHQTD----------NVIDQLKKENDHYQLQVQELTDLLKSKNEED 299
+ T+ +++ + + + V+D L++E + + Q L+ L+ E
Sbjct: 244 ADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEH 303
Query: 300 DPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQE 359
+ + V + EE K++L + E+ E + HNL+E++ + +++ Q ++
Sbjct: 304 NTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG--QAQAELES 361
Query: 360 RDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEK 419
R S ++ +++ EME+ T I L+ Q + A + + K+ L E+
Sbjct: 362 RYSALE------QKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL---LQDKNEQ 412
Query: 420 TKEAERTAELAEADAREKDKELVEALKRL----------------------KDYESGVYG 457
++ +T + E ++K KE+ + L RL E +
Sbjct: 413 AVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIAS 472
Query: 458 LEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDL 517
L+ VVE++N K + + E+E L E KL +I+ +N + +++D+
Sbjct: 473 LQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDI 532
Query: 518 TEFRNSKHLKQQQYRAEN---------QILLKEIESLEEERLDLKKKIRQMAQERGKRSA 568
R+S + Q EN +LL E++ +EE LK Q +GKR+
Sbjct: 533 ANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLK------LQLQGKRAE 586
Query: 569 TSGLTTEDLNLTENISQGDRISERKLDLL----------------SLKNMSEAQSKNEFL 612
+ D + + +G+ I+ K+ + SL + + Q+ E
Sbjct: 587 EADHEVLDQKEMKQM-EGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQ 645
Query: 613 SR------------ELIEKERDLERSRTVIAKF----QNKLKELVEENKQLEEGMKEILQ 656
SR EL ++D ++S + + Q++L+ L + +LE +
Sbjct: 646 SRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFH---K 702
Query: 657 AIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELR 716
A + +K+ D K E I +L +L+ + KNA+ A L + DQL + +EL
Sbjct: 703 AQEIYEKNLDEKAKE----ISNLNQLIEEFK-KNADNNSSAFTALSEERDQLLSQVKELS 757
Query: 717 QELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASI 776
+ E R + LA+A E++ L +S+ ++
Sbjct: 758 M-VTELRAQVKQLEMNLAEA-------ERQRRLDYESQTAH------------------- 790
Query: 777 INSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTE 836
N E + L E ++K+ K++ L++ L+D +F+ +QS L + S+ + ++E
Sbjct: 791 DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFS----EQSTLIRSLQSQLQNKESE 846
Query: 837 -------SKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKIT-- 887
+ I + +L + Q +++ + + LL + D + +++ + E +++T
Sbjct: 847 VLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEI 906
Query: 888 -------VLQVNEK--SLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRF 938
++Q+NE+ SL + TL E + L E+ K E + + EV G Q +
Sbjct: 907 SFSMTEKMVQLNEEKFSLGVEIKTLKE-QLNLLSRAEEAKKEQVEEDNEVSS--GLKQNY 963
Query: 939 KEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLEC 998
EM+ A Q + E +L K+ + K + L L+QR S LE
Sbjct: 964 DEMS----PAGQ--ISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE--- 1014
Query: 999 ENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKK 1058
E +LK++ + KE+ +++ + +E+ ++E K +E + + I +IS+K
Sbjct: 1015 ELANLKDESK---KEIPLSETERGEVEE--DKENKEYSEKCVTSKCQEIEIYLKQTISEK 1069
Query: 1059 ITMLE--MKELNERQRAEH-----CQKMYEHLRTSLKQMEERNFELETKFAELTKI---N 1108
L+ K+L E+ AE ++M + L+ Q++ E+ A + K+ N
Sbjct: 1070 EVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSN 1129
Query: 1109 LDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKL-REISDIARRQVE 1167
DA + + + +S + + ELE+ + L+ E +L +++ + +
Sbjct: 1130 TDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKA 1189
Query: 1168 ILNAQQQSRDKEVESLRMQLLDY---QAQSDEKSLIAKLHQHNVSLQLSEATALGKLESI 1224
IL Q+ E L+ Q DY Q Q DE+S N+ QL + + ESI
Sbjct: 1190 ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQS----KENENIGDQLRQ-LQIQVRESI 1244
Query: 1225 TSKL-----QKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHL---RQTIQSLRRQFSG 1276
KL Q+ + LE+ L + + + + N + +L+ S
Sbjct: 1245 DGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSV 1304
Query: 1277 ALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELI---- 1332
A AQ ++ ++L+ E+ +E ++ + + L+++ L+ +
Sbjct: 1305 AQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAE 1364
Query: 1333 ----STLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISS 1388
S + + +Q I + EL+ + +L + + K +E++ YL+ +SE E ++
Sbjct: 1365 VHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTK 1424
Query: 1389 LEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLP 1448
++ EI++Q + Q E+ + + + Q E+ QK EE G
Sbjct: 1425 IQTEIIEQEDLIKALH---TQLEMQAKEHDERIKQLQVELCEMKQKPEE-IGEESRAKQQ 1480
Query: 1449 LPNQLEIAL----RKIKENIRIILE---TRATCKSLEEKLKEKESALRLAEQNILSRDKV 1501
+ +L+ AL +KEN + E R T + L + L + ES +++ QN +D V
Sbjct: 1481 IQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVES--QVSAQN-KEKDTV 1537
Query: 1502 INELRLRLPATAEREKLIAELGRKEME----PKSHHTLKIAHQTIANMQARLNQKEEVLK 1557
+ L L ER+KLI E+ R +E S +LK+A + + + +L ++ E LK
Sbjct: 1538 LGRLAL---LQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLK 1594
Query: 1558 KYQRLLEKA--REEQREIVKKHE------EDLHILHHRLELQADSSLNKFKQTAWDLMKQ 1609
++ E +E+ +E+ K++E E++ R++ ++ + ++ L
Sbjct: 1595 S-SKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRST 1653
Query: 1610 SPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKV------- 1662
T K +L E EQ + E + + ++ +LE + + +V
Sbjct: 1654 EANKKETEK---QLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTA 1710
Query: 1663 KEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQ---------AQKE 1713
KE L + ++E+++VK E E L E L E+Q K+
Sbjct: 1711 KECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQ 1770
Query: 1714 ANSRAPT--TTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKE 1771
AN A N+ E + + ++Q +LS + +E +A+ + +
Sbjct: 1771 ANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFS 1830
Query: 1772 AHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNEL----- 1826
+H + + + +LK ++ L E K KE +T +N +N+L ++ + EL
Sbjct: 1831 SHDEINNYL-QQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQE 1889
Query: 1827 ---------QKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQG------KPLTDN-- 1869
Q+ Q+ +++ + KE ++E D+L+ ++ + L G + +TD
Sbjct: 1890 EVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQI 1949
Query: 1870 KQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKL 1929
K L+E + +KK ++LE + +++ +KEK E IR E +K Q + NK
Sbjct: 1950 KNELLESEMKNLKKCVSELEEEKQQL----VKEKTKVESEIRKEYLEKIQGAQKEPGNKS 2005
Query: 1930 KEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEEL 1989
KE + KQ +K L K+ + Q K+ TV + L ES+K+L E+
Sbjct: 2006 HAKELQELLKEKQ-QEVKQL----QKDCIRYQEKISALERTV-KALEFVQTESQKDL-EI 2058
Query: 1990 KKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPS---I 2046
K NL QA +++R + A K DT S+ +
Sbjct: 2059 TKENL-----------AQA-----------VEHRKKAQAELASFKVLLDDTQSEAARVLA 2096
Query: 2047 SGIESDDHCQREQELQKENLKLSSENIELKFQLEQA-NKDLPRLKNQVRDLKEMCEFLKK 2105
++ Q +E K +K E++E + LEQA K L KN ++E + L++
Sbjct: 2097 DNLKLKKELQSNKESVKSQMKQKDEDLERR--LEQAEEKHLKEKKN----MQEKLDALRR 2150
Query: 2106 EKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMAN 2165
EK ++ +TI E++ T+ K V+++Q EN ++ M++
Sbjct: 2151 EKVHLE-------------ETIGEIQVTLNKKDKEVQQLQ-ENLDSTVTQLAAFTKSMSS 2196
Query: 2166 IEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRI 2225
++ + +++ E +K + + S +SK + L+ +L++ + E+L+I
Sbjct: 2197 LQDDRDRVIDEAKKWE----RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKI 2252
Query: 2226 AKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTR-MY---ETKLKE 2281
N+ L + + +Q + L+G + + + TR +Y + +L +
Sbjct: 2253 ---NISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAK 2309
Query: 2282 LETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKREL 2341
LE+++ +TDL +++ E++ + E I+ K E ET+ REL
Sbjct: 2310 LESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASREL 2369
Query: 2342 QVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQH 2401
RL H+ K + I + + K+++ + Q ++IK+LE L + E
Sbjct: 2370 -TSRL--HEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIV 2426
Query: 2402 LKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLS 2449
L+EE KK + +E LK KE +++ L+ VK +S
Sbjct: 2427 LEEENKKAVDKTNQL-------METLKTIKKENIQQKAQLDSFVKSMS 2467
Score = 263 bits (672), Expect = 2e-69
Identities = 534/2604 (20%), Positives = 1083/2604 (41%), Gaps = 471/2604 (18%)
Query: 20 RQEELADNLLISLSKVEVNELKSEKQENV---------------IHLFRITQSLMKMKAQ 64
++ + L + ++E+N ++E+Q + IH I +K +
Sbjct: 754 KELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIE 813
Query: 65 EVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQL 124
++ L++V+ EQ+ L++++ E+E+ G R + +++ +L + L
Sbjct: 814 VLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEV-----LEGAERVRHISSKVEELSQAL 868
Query: 125 EQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQ 184
QK+ E+ M++ L ++K+ E L EE + + +++ + + +K QL ++
Sbjct: 869 SQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEI---SFSMTEKMVQLNEEKFSLG 925
Query: 185 KQIDSQKE--TLLSRRGE--------DSDYRSQLSKKNYELIQYLDEI--QTLTEANEKI 232
+I + KE LLSR E D++ S L K+NY+ + +I + L + +
Sbjct: 926 VEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGL-KQNYDEMSPAGQISKEELQHEFDLL 984
Query: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLL 292
+ +N++ ++ L+ ++ +++ +R++ + N+ D+ KKE + + E+ +
Sbjct: 985 KKENEQRKRKLQAALINRKELLQRVSRLE---EELANLKDESKKEIPLSETERGEVEEDK 1041
Query: 293 KSKNEEDDPIMVAVNAKVEEWKLILSSK-DDEIIEYQQMLHNLREKLKNAQLDADKSNVM 351
++K + V +K +E ++ L ++ +E Q + +L EKL A + ++ V
Sbjct: 1042 ENKEYSEK----CVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKL--AAEEQFQALVK 1095
Query: 352 ALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDL--KNELQRNKGASTLSQQT---- 405
+ Q +Q++ +QI +L ++ + N II+ L N + + L ++T
Sbjct: 1096 QMNQTLQDKTNQIDLLQAEISE-------NQAIIQKLITSNTDASDGDSVALVKETVVIS 1148
Query: 406 --------HMK---------IQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRL 448
H K ++ + L++K +EA + + A+EK++ L E LK+
Sbjct: 1149 PPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQ 1208
Query: 449 KDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLD-------ENE 501
KD + + Q + +E E + ++ +L++++ + +D + E
Sbjct: 1209 KD-------------DYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE 1255
Query: 502 ALRERVGLEPKTMIDLTEFRNSKHLKQQQY------RAENQILLK----------EIESL 545
+ GLE + + TE +++ + + +E+ L+ +++ +
Sbjct: 1256 SCSSTPGLE-EPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEI 1314
Query: 546 EEERLDLKKKIRQMAQERGKRSAT----------SGLTTEDLNLTENISQ------GDRI 589
E E+++L+ K+ E K+S GL E L + ++ ++
Sbjct: 1315 EAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL 1374
Query: 590 SERKLDLLSLKNMSEAQSKNE--------------FLSRELIEKERDLERSRTVIAKFQN 635
+L + L+++ E Q K + +LS +L EKE L + +T I + ++
Sbjct: 1375 ESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQED 1434
Query: 636 KLK----ELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNA 691
+K +L + K+ +E +K++ + EM++ P+ G E+ R I+ K
Sbjct: 1435 LIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEES--------RAKQQIQRKLQ 1486
Query: 692 EGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLA--KANLKIDHLEKETSL 749
+ LK N+ L++EL +R ++ LA ++ + + EK+T L
Sbjct: 1487 AALISRKEALK--------ENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVL 1538
Query: 750 LRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLED------ 803
R + K I D + S+ +S + L E+KEK +K +E
Sbjct: 1539 GRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKI 1598
Query: 804 -SLEDYNRKFAVIRHQQSLLYKEY---LSEKETWKTESKTIKEEKRKLEDQVQQDAIKVK 859
++ K ++ + +L + Y +E E + + +++EK++L +++ K
Sbjct: 1599 AESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKK 1658
Query: 860 EYNNLLNALQMDSDEMK----KILAENSRKITVLQVNEKSLIRQY----TTLVELERQLR 911
E L + + +EMK K +KI L+ L + T E L
Sbjct: 1659 ETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLL 1718
Query: 912 KENEKQKNEL--LSMEAE-VCEKIGCLQRFKEMAIFKIAALQKVVDNSVSL-SELELANK 967
N K EL + ME E + +K L K+ ++ L+ ++ +VS + LE K
Sbjct: 1719 SSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEK 1778
Query: 968 QYNELTAKYR-------DILQKDNMLVQ------------RTSN-------LEHLECENI 1001
N+ + ++D++ + +++N H E N
Sbjct: 1779 HDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNY 1838
Query: 1002 -----SLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDK---------AKKSI 1047
LKE++ + +E + KE T+E E+ T L S+ D K ++
Sbjct: 1839 LQQIDQLKERIAGLEEEKQKNKEFSQTLEN--EKNTLLSQISTKDGELKMLQEEVTKMNL 1896
Query: 1048 TNSDIVSISKKITML------EMKELNER---QRAE-------HCQKMY------EHLRT 1085
N I ++T L E +L ER Q AE +CQ + E L +
Sbjct: 1897 LNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLES 1956
Query: 1086 SLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDA-------DRQRI 1138
+K +++ ELE + +L K + KVE +R E + + A + + Q +
Sbjct: 1957 EMKNLKKCVSELEEEKQQLVK---EKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQEL 2013
Query: 1139 LELEKNEM-ELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEK 1197
L+ ++ E+ +L+ + + +E R V+ L Q K++E + L QA K
Sbjct: 2014 LKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLA--QAVEHRK 2071
Query: 1198 SLIAKLHQHNVSLQLSEATALGKL--------------ESITSKL-QKMEAYNLRLEQKL 1242
A+L V L +++ A L ES+ S++ QK E RLEQ
Sbjct: 2072 KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAE 2131
Query: 1243 DE--KEQALYYARLEGRNRAK-HLRQTIQSLR----------RQFSGALP--LAQQEKFS 1287
++ KE+ +L+ R K HL +TI ++ +Q L + Q F+
Sbjct: 2132 EKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFT 2191
Query: 1288 KTMIQLQNDKLKIMQEMKNSQQEHRN-MENKTLEMELKLKGLEELISTLKDTKGAQKVIN 1346
K+M LQ+D+ +++ E K +++ + +++K E+ LK E+ S LKD +
Sbjct: 2192 KSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLK----EDNCSVLKDQLRQMSI-- 2245
Query: 1347 WHMKIEELRLQELKLNRELVKDKEEI------KYLNNIISEYERTISSLEEEIVQQNKFH 1400
HM+ ++ + L+ ++++ + K + K + + E + +S LEE ++ +H
Sbjct: 2246 -HMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEET---RHLYH 2301
Query: 1401 EERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGS----IPDPSLPLPN----- 1451
+ LE +L Q ++ N+ +K +E G+ I + N
Sbjct: 2302 SSQNEL-----AKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSY 2356
Query: 1452 -QLEIALRKIKE-NIRIILETRATCKSLEEKLKEKESALRLAEQNILSR-DKVINELRLR 1508
QLE L+ +E R+ E + + L KE A+++A + + DK I EL
Sbjct: 2357 EQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELE-N 2415
Query: 1509 LPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKARE 1568
L + E E ++ E K+ K++ + +T+ ++ Q++ L + + + +
Sbjct: 2416 LLSQEEEENIVLEEENKKAVDKTNQLM----ETLKTIKKENIQQKAQLDSFVKSMSSLQN 2471
Query: 1569 EQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQ 1628
++ IV +++ L H + L+ D + + NK + +
Sbjct: 2472 DRDRIVGDYQQ-LEERHLSIILEKDQLIQE-------------AAAENNKLKEEIRGLRS 2517
Query: 1629 TVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEV- 1687
+ + + + L +L + +DL + I + + K+ +++QLQ+N E E K K E
Sbjct: 2518 HMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQL--LEVQLQQNKELENKYAKLEEK 2575
Query: 1688 --------EDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVER-----LKSQL 1734
EDL+ + Q+E Q L E+++ K + S+ T + L E +QL
Sbjct: 2576 LKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQL-TRQVTALQEEGTLGLYHAQL 2634
Query: 1735 ALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELK------ 1788
+KE++ LS AL + A EE ++ QKEA V +I D+ +ELK
Sbjct: 2635 KVKEEEVHRLS-ALFSSSQKRIAELEEELVCV--QKEAAKKVGEIEDKLKKELKHLHHDA 2691
Query: 1789 ----TQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEID 1844
+ E E + +L L + + +T L ++Q ++ + + ++ +
Sbjct: 2692 GIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHAN 2751
Query: 1845 QENDELKRQ----IKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPM 1900
+E DELKR+ +K L + L + +L+ E + E +E+++ + +
Sbjct: 2752 EELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLL 2811
Query: 1901 KEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKD----LFAKADKE 1956
+ E+L+ + ++L++ +V + +K + +L++ L+ + +K
Sbjct: 2812 SKD---EQLLH-------------LSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKF 2855
Query: 1957 KLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVE 2016
+ + + K ++ + S E++ LKK L+ND RD +++
Sbjct: 2856 RKSEEGKQRSAA---------QPSTSPAEVQSLKKAMSSLQND-----------RDRLLK 2895
Query: 2017 DL-HLQNRYLQ-----EKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSS 2070
+L +LQ +YLQ +LH L+ Q E D + Q +Q+E L
Sbjct: 2896 ELKNLQQQYLQINQEITELHPLKAQLQ------------EYQDKTKAFQIMQEE---LRQ 2940
Query: 2071 ENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPEL 2130
EN+ + +L Q + + R +KE +K ++L H++ I EL
Sbjct: 2941 ENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDK---DQQLSHLQN------LIREL 2991
Query: 2131 EKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSM 2190
+ + + + QR+ AS + N+ E E L+ +L + HQ +
Sbjct: 2992 RSSSSQTQPLKVQYQRQASPETSAS----PDGSQNLVYETELLRTQLNDSLKEI-HQKEL 3046
Query: 2191 HYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNL-EILN-----EKMTVQLEET 2244
+ +++ E L +L D ++ LR + + ++LN EK +L+
Sbjct: 3047 RIQQLNSNFSQLLEEKNTLSIQL---CDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAG 3103
Query: 2245 GKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEAT 2304
+ A + G KS + R + E + + Q + +L++L++E
Sbjct: 3104 PLNIDVAPGAPQEKNGVHRKSDPEEL--REPQQSFSEAQQQLCNTRQEVNELRKLLEE-- 3159
Query: 2305 EREQKVNKYN--EDLEQQIKILKH 2326
ER+Q+V N E+QI+ L+H
Sbjct: 3160 ERDQRVAAENALSVAEEQIRRLEH 3183
Score = 262 bits (669), Expect = 4e-69
Identities = 537/2724 (19%), Positives = 1108/2724 (40%), Gaps = 419/2724 (15%)
Query: 32 LSKVEVNELKSEKQE--NVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQ--L 87
LS +E+ ELK+E ++ + I L + + E+++ ++ A+ Q L
Sbjct: 489 LSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVL 548
Query: 88 KTKVMKLENELE--MAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDME--KELEKEKK 143
+ + EL + + + FL+ ++ K+ E+ D E+ D + K++E E
Sbjct: 549 ENTFSQKHKELSVLLLEMKEAQEEIAFLKLQL--QGKRAEEADHEVLDQKEMKQMEGEGI 606
Query: 144 VNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSD 203
++ + E+ + + E L ++ + Q + +E L+ G +
Sbjct: 607 APIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQAST----EHQSRTSEEISLNDAGVELK 662
Query: 204 YRSQLSKKNYELIQ-----YLDEIQTLTEANEKIEV---QNQEM-RKNLEESVQEMEKMT 254
Q K+ + + DE++ L ++E+ + QE+ KNL+E +E+ +
Sbjct: 663 STKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLN 722
Query: 255 DEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWK 314
K + L +E D QV+EL+ + + + + M A+ + +
Sbjct: 723 QLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAE-RQRR 781
Query: 315 LILSSK--DDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVE 372
L S+ D ++ Q ++ K K+ +++ ++ + +Q E+ + I+ L Q++
Sbjct: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQ 841
Query: 373 QYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEA 432
E+ + + + ++++ S Q ++I +L EK ++ E + E
Sbjct: 842 NKESEVLEGAERVRHISSKVEE---LSQALSQKELEITKMDQLLLEKKRDVETLQQTIE- 897
Query: 433 DAREKDKELVE----ALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEI-- 486
EKD+++ E +++ + L VEIK K Q+ + R E +++
Sbjct: 898 ---EKDQQVTEISFSMTEKMVQLNEEKFSLG---VEIKTLKEQLNLLSRAEEAKKEQVEE 951
Query: 487 -NKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAEN-QILLKEIES 544
N++ + DE + E + DL + N + ++ Q N + LL+ +
Sbjct: 952 DNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSR 1011
Query: 545 LEEERLDL----KKKIRQMAQERG------------KRSATSGLTTEDLNLTENISQGD- 587
LEEE +L KK+I ERG ++ TS ++ L + IS+ +
Sbjct: 1012 LEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEV 1071
Query: 588 RISERKLDL-LSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQ 646
+ + DL L + Q+ + +++ L +K ++ + I++ Q +++L+ N
Sbjct: 1072 ELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTD 1131
Query: 647 LEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAE---GIFDASLHLKA 703
+G + + +KE G + P LE + A+E + + + +A KA
Sbjct: 1132 ASDG--DSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKA 1189
Query: 704 QVDQLTGRNEELRQELR--------------ESRKEAINYSQQLAKANL--------KID 741
+ + + LR+EL+ E KE N QL + + K+
Sbjct: 1190 ILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLP 1249
Query: 742 HLEKETSLLRQSEGSNVVFKGI---------------DLPDGIAPSSASIINSQNEYLIH 786
+++ S +FK D P +SA + +
Sbjct: 1250 STDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKA 1309
Query: 787 LLQELENKEKKLK-NLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKR 845
L+E+E ++ +L+ + + + +K + Q + K+ L E E+ KT S +
Sbjct: 1310 QLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGL-EIESLKTVSHEAEVHAE 1368
Query: 846 KLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVL--QVNEK--------- 894
L+ +++ +++ + L LQ DE++K++++ ++ L Q++EK
Sbjct: 1369 SLQQKLESSQLQIAGLEH-LRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQT 1427
Query: 895 SLIRQYTTLVELERQLRKENEKQKNELLSMEAEVC------EKIGCLQRFKEMAIFKIAA 948
+I Q + L QL + ++ + ++ E+C E+IG R K+ K+ A
Sbjct: 1428 EIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQA 1487
Query: 949 L-----QKVVDNSVSLSELELANKQYNELTAKYRDI--------LQKDNMLVQRT----- 990
+ + +N EL LA LT D+ +KD +L +
Sbjct: 1488 ALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEE 1547
Query: 991 -----SNLEHLECENISLKEQVESINKELE-ITKEKLHTIEQAWE-QETKLGNESSMDKA 1043
+ ++ EN SL ES+ LE +T++K +++ + +K+ + +
Sbjct: 1548 RDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEK 1607
Query: 1044 KKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAE 1103
K + K+ +L N AE Q + E +R ++ +E +L + A
Sbjct: 1608 HK--------ELQKEYEILLQSYENVSNEAERIQHVVEAVR---QEKQELYGKLRSTEAN 1656
Query: 1104 LTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIAR 1163
+ Q+ EQ + +E+ + + K + + +Q+ILELE+ L+ EV D A+
Sbjct: 1657 KKETEKQLQEAEQEM-EEMKEKMRK-FAKSKQQKILELEEENDRLRAEV---HPAGDTAK 1711
Query: 1164 RQVEILNAQQQSRDKEVESLRMQL----LDYQAQSDEKSLIAKLHQ---HNVSLQLSEAT 1216
+E L + S +E+E ++M+ +Q+ EK +++ Q H + +S+
Sbjct: 1712 ECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQA 1771
Query: 1217 ALGKLE--------------SITSKLQKMEAYNLRLEQKLDEKEQALYYAR------LEG 1256
L E SI + ++ ++ ++ E + A
Sbjct: 1772 NLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSS 1831
Query: 1257 RNRAKHLRQTIQSLRRQFSGALPLAQQEK-FSKTM----------IQLQNDKLKIMQE-- 1303
+ + Q I L+ + +G Q+ K FS+T+ I ++ +LK++QE
Sbjct: 1832 HDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEV 1891
Query: 1304 --------------------MKNSQQEHRNMENKTLE----------------------- 1320
+ +++E ++E + +
Sbjct: 1892 TKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKN 1951
Query: 1321 --MELKLKGLEELISTLKDTKGAQKVINWHMKIE-ELRLQELKLNRELVKD---KEEIKY 1374
+E ++K L++ +S L++ K Q+++ K+E E+R + L+ + K+ K K
Sbjct: 1952 ELLESEMKNLKKCVSELEEEK--QQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKE 2009
Query: 1375 LNNIISEYERTISSLEEEIVQ-QNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQ 1433
L ++ E ++ + L+++ ++ Q K + V E Q D+ ++N + A +
Sbjct: 2010 LQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKEN-LAQAVE 2068
Query: 1434 KFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEK----ESALR 1489
++A + + L + A R + +N+++ E ++ +S++ ++K+K E L
Sbjct: 2069 HRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLE 2128
Query: 1490 LAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARL 1549
AE+ L K + E +L A REK+ E +TI +Q L
Sbjct: 2129 QAEEKHLKEKKNMQE---KLDA-LRREKVHLE------------------ETIGEIQVTL 2166
Query: 1550 NQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQ 1609
N+K++ +++ Q L+ + K L+ D +++ K+ W+ ++
Sbjct: 2167 NKKDKEVQQLQENLDSTVTQLAAFTKSMSS--------LQDDRDRVIDEAKK--WE--RK 2214
Query: 1610 SPTPVPTNKHFIRLAEMEQTV-AEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENI 1668
+ + + IRL E +V +Q +S + +LK LE ++I E K + +
Sbjct: 2215 FSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQL 2274
Query: 1669 KLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVE 1728
+ ++ + + E K++ +++E+ ++L SQ E L+SEL++ K+ T + N +E
Sbjct: 2275 QQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKD-----QLTDLSNSLE 2329
Query: 1729 RLKSQLALKE---KQQKA-----------------LSRALLELRAEMTAAAEERIISATS 1768
+ K Q E +QQ+A SR L E E++IIS S
Sbjct: 2330 KCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLS 2389
Query: 1769 QKEAHLNV-----QQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLN 1823
KE + V +Q D+ +EL+ + E + L+E K + ++ N L + L +
Sbjct: 2390 GKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIK 2449
Query: 1824 NELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKK 1883
E +++ + ++ + + D + ++L + + K LI+E + K
Sbjct: 2450 KENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEE--RHLSIILEKDQLIQEAAAENNK 2507
Query: 1884 LENQLEGKVEEVDLKPMKEKNAK--EELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTK 1941
L+ ++ G +D + +NAK ELI++ E I+ + K L
Sbjct: 2508 LKEEIRGLRSHMD--DLNSENAKLDAELIQYREDLNQVITIKDSQQKQ--------LLEV 2557
Query: 1942 QLNTLKDLFAKADKEKLTLQRKLK-TTGMTVDQVLGIRALESEKELEELKKRNLDLENDI 2000
QL K+L K K L+ KLK + D AL+ EK ++L K L+ I
Sbjct: 2558 QLQQNKELENKYAK----LEEKLKESEEANEDLRRSFNALQEEK--QDLSKEIESLKVSI 2611
Query: 2001 LYM-RAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQ 2059
+ R AL + + H Q + +E++H L FS S+ I+ +E + C
Sbjct: 2612 SQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSS---SQKRIAELEEELVC---- 2664
Query: 2060 ELQKENLKLSSE-NIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKL---- 2114
+QKE K E +LK +L+ + D ++N+ +E L ++ E+++KL
Sbjct: 2665 -VQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVT 2723
Query: 2115 -------GHVRGSGRSGKTI----PELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKM 2163
++ GRS ++ + + +K+ + +E QLK+ G+L E+
Sbjct: 2724 KENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKE-QGLLNRERD 2782
Query: 2164 ANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKL 2223
A + + + + E +HL +L+ SK + + ++ E +++ + A L
Sbjct: 2783 ALLSETAFSMNSTEENSLSHL-EKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASL 2841
Query: 2224 RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYE-----TK 2278
+ +++L NE + E GK+ A+ P A+ +S K + + + +
Sbjct: 2842 QNERDHL--WNELEKFRKSEEGKQRSAAQ---PSTSPAEVQSLKKAMSSLQNDRDRLLKE 2896
Query: 2279 LKELETDIAKKNQSITDLKQLVKEATEREQKVNKY---NEDLEQQIKILKH--------- 2326
LK L+ + NQ IT+L L + E + K + E+L Q+ +H
Sbjct: 2897 LKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEK 2956
Query: 2327 ----VPEGAETEQ-------------GLKRELQVLRLANHQLDKEKAELIHQI--EANKD 2367
+ E EQ L+ ++ LR ++ Q K + Q E +
Sbjct: 2957 SSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSAS 3016
Query: 2368 QSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDL 2427
G+++ + + + L+ ++ D ++ +L Q L +L +E + + L
Sbjct: 3017 PDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSL 3076
Query: 2428 KYN---YKEEVKKNILLEEKVKKL 2448
+ N Y + + +LE++V++L
Sbjct: 3077 RENQQHYGDLLNHCAVLEKQVQEL 3100
Score = 259 bits (663), Expect = 2e-68
Identities = 536/2687 (19%), Positives = 1103/2687 (41%), Gaps = 442/2687 (16%)
Query: 38 NELKSEKQENVIHLFRITQSLMKMKA------QEVELALEEVEKAGEEQAKFENQLKT-- 89
N +++E++E+ I L ++ + + K +E+ LE+ E+AG+ QA+ E++
Sbjct: 308 NTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALE 367
Query: 90 ---------------KVMKLENELEMAQQSAGGRDTRFLRNE----------ICQLEKQL 124
+ K EL+ A + ++++ L+++ I QLE QL
Sbjct: 368 QKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQL 427
Query: 125 EQKDRELEDMEKEL------------------EKEKKVNEQ----LALRNEEAENENSKL 162
+QK +E+ L E + V E+ L R E ENE L
Sbjct: 428 QQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGAL 487
Query: 163 ---RRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYL 219
E + LK +NE+L I + Q +R GE S++S ++
Sbjct: 488 LLSSIELEELKAENEKLSSQITLLEAQ---------NRTGEADREVSEIS-----IVDIA 533
Query: 220 DEIQTLTEANEKIEVQNQEMRKNLEESV--QEMEKMTDEYNRMKAIVHQTDNVIDQLKKE 277
++ + E + + ++N +K+ E SV EM++ +E +K + + +E
Sbjct: 534 NKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKL------QLQGKRAEE 587
Query: 278 NDHYQLQVQELTDL-------LKSK-----NEEDDPIMVAVNAKVEEWKLILSSKDDEII 325
DH L +E+ + +K K +D P+M EE L K+
Sbjct: 588 ADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLM-----PNEESSLPAVEKEQAST 642
Query: 326 EYQQ------MLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQV-------- 371
E+Q L++ +LK+ + D DKS + A+ Q +++ L Q+
Sbjct: 643 EHQSRTSEEISLNDAGVELKSTKQDGDKS-LSAVPDIGQCHQDELERLKSQILELELNFH 701
Query: 372 ---EQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAE 428
E Y K +++ I +L ++ K + + + D L + KE E
Sbjct: 702 KAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTE 761
Query: 429 LAEADAREKDKELVEA-LKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEIN 487
L A ++ + L EA +R DYES +I + + K +D +IE+L E++
Sbjct: 762 L-RAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELD 820
Query: 488 KLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEE 547
++L+ S+ +L+ ++ + +++ E +H+ + + KE+E +
Sbjct: 821 DVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE--RVRHISSKVEELSQALSQKELEITKM 878
Query: 548 ERLDLKKK-----IRQMAQERGKR--SATSGLTTEDLNLT-ENISQGDRISERKLDLLSL 599
++L L+KK ++Q +E+ ++ + +T + + L E S G I K L L
Sbjct: 879 DQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLL 938
Query: 600 KNMSEAQSK-----NEF----------------LSRELIEKERDL------ERSRTVIAK 632
EA+ + NE +S+E ++ E DL +R R + A
Sbjct: 939 SRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAA 998
Query: 633 FQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAE 692
N+ KEL++ +LEE + + K+ + + GE + E + SK E
Sbjct: 999 LINR-KELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQE 1057
Query: 693 GIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQ 752
++LK + + + +R++L E + + + N + + LL+
Sbjct: 1058 ----IEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQA 1113
Query: 753 SEGSN------VVFKGIDLPDG--IAPSSASIINSQ--NEYLIHLLQELENKEKKLKNLE 802
N ++ D DG +A +++ S H EL E+K+ LE
Sbjct: 1114 EISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPEL---EEKILALE 1170
Query: 803 DSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYN 862
E +K + + K+ ++ + E K K++ +L++Q + + + +
Sbjct: 1171 KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIG 1230
Query: 863 NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELL 922
+ L LQ+ ++ K+ E ++ LE L K E+ + +
Sbjct: 1231 DQLRQLQI------QVRESIDGKLPSTDQQESC-----SSTPGLEEPLFKATEQHHTQPV 1279
Query: 923 SMEAEVC-------EKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAK 975
+E+ +C E LQ +A K A L+++ V L EL++++ +ELT K
Sbjct: 1280 -LESNLCPDWPSHSEDASALQGGTSVAQIK-AQLKEIEAEKVEL-ELKVSSTT-SELTKK 1335
Query: 976 YRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLG 1035
++ Q + ++ +E L+ + + ES+ ++LE ++ ++ +E E + KL
Sbjct: 1336 SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395
Query: 1036 NESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNF 1095
+ K+ + +S+K L + ++ + + ++ L K+ +ER
Sbjct: 1396 ELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIK 1455
Query: 1096 ELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKL 1155
+L+ + E+ QK E++ + A + A E K L+ E+S
Sbjct: 1456 QLQVELCEM------KQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLA 1509
Query: 1156 REISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQ---HNVSLQL 1212
R + + + + +Q +++KE +++ +L Q + D+ LI ++ + N SL
Sbjct: 1510 RGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDK--LITEMDRSLLENQSLSS 1567
Query: 1213 SEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRR 1272
S + LE +T +K L ++++ + + E + + K L++ + L +
Sbjct: 1568 SCESLKLALEGLTEDKEK-------LVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ 1620
Query: 1273 QFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELI 1332
+ + E+ + ++ +K ++ ++++++ + E + E E +++ ++E +
Sbjct: 1621 SYENV--SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKM 1678
Query: 1333 STLKDTKGAQKVINWHMKIEELRLQE--------------LKLNRELVKDKEEIKYLNNI 1378
+K QK++ + + LR + L N + ++ E +K
Sbjct: 1679 RKFAKSK-QQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVK----- 1732
Query: 1379 ISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEA 1438
EYE + + +++ EE Q Q E ++ +Q ++ ++++ N EE
Sbjct: 1733 -MEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHD--NQTNVTEEG 1789
Query: 1439 TGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSR 1498
T SIP + +E + + TR TC E + +SA ++ S
Sbjct: 1790 TQSIPG--------------ETEEQDSLSMSTRPTC---SESVPSAKSANPAVSKDFSSH 1832
Query: 1499 DKV------INELRLRLPA-------------TAEREK--LIAELGRKEMEPKSHHTLKI 1537
D++ I++L+ R+ T E EK L++++ K+ E LK+
Sbjct: 1833 DEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGE------LKM 1886
Query: 1538 AHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLN 1597
+ + M Q +E L + +L E A EE+ ++ ++ +++ EL + S+
Sbjct: 1887 LQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEER------LMNQLAEL--NGSIG 1938
Query: 1598 KFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQ--- 1654
+ Q D ++ K+ +++ V+E ++ L+ + KV ++ ++
Sbjct: 1939 NYCQDVTDAQIKNELLESEMKN------LKKCVSELEEEKQQLVKEKTKVESEIRKEYLE 1992
Query: 1655 ---------------REITELKVKEFENIKLQLQEN---HEDEVKKVKAEVEDLKYLLDQ 1696
+E+ EL ++ + +K QLQ++ +++++ ++ V+ L+++ +
Sbjct: 1993 KIQGAQKEPGNKSHAKELQELLKEKQQEVK-QLQKDCIRYQEKISALERTVKALEFVQTE 2051
Query: 1697 SQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRAL---LELRA 1753
SQK+ + K L E +A L S L + Q +R L L+L+
Sbjct: 2052 SQKDLEITKENLAQAVEHRKKAQA--------ELASFKVLLDDTQSEAARVLADNLKLKK 2103
Query: 1754 EMTAAAEERIISATSQKEAHL--NVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNR 1811
E+ + +E + S QK+ L ++Q ++H +E K E L +AL+ K
Sbjct: 2104 EL-QSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKL--------DALRREKVH 2154
Query: 1812 ENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQ 1871
L + + ++ L KK K E +++ + D Q+ T + L D++
Sbjct: 2155 ---LEETIGEIQVTLNKKDK-------EVQQLQENLDSTVTQLAAFTKSMSS--LQDDRD 2202
Query: 1872 SLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEEL----IRWEEGK----------- 1916
+I+E ++ +K + ++ K EE+ LK K++L I EE K
Sbjct: 2203 RVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQ 2262
Query: 1917 KWQAKIEGIRNKLKEK-----EGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTV 1971
W++K + +L++K +GE L QL + L+ + E L+ +LK+
Sbjct: 2263 IWESKAQ-TEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKS----- 2316
Query: 1972 DQVLGIRALESEKELEELKKRNLDLENDILYMRA---HQALPRDSVVEDLHLQNRYLQEK 2028
L + + LE+ K++ +LE I A + + + DL +R L +
Sbjct: 2317 ---LKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQ-ASRELTSR 2372
Query: 2029 LHALEKQFSKDTYSKPSISGIES----------DDHCQREQEL-------QKENLKLSSE 2071
LH E+ K+ +SG E H + +EL ++EN+ L E
Sbjct: 2373 LH--EEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEE 2430
Query: 2072 NIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELE 2131
N + + Q + L +K + K + K + +Q + G + + E
Sbjct: 2431 NKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQ---LEERH 2487
Query: 2132 KTIGLMK-KVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSM 2190
+I L K +++++ EN +LK+ L S M ++ EN KL AEL + + L +++
Sbjct: 2488 LSIILEKDQLIQEAAAENNKLKEEIRGLRSH-MDDLNSENAKLDAELIQYREDLNQVITI 2546
Query: 2191 HYESKTKGTEKIIAENE-------RLRKELKKETDAAEKLRIA-------KNNLEILNEK 2236
+ + E + +N+ +L ++LK+ +A E LR + K +L E
Sbjct: 2547 KDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIES 2606
Query: 2237 MTVQLEETGKRLQFAESRG------PQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN 2290
+ V + + +++ + G QL+ + + + + + ++ ELE ++
Sbjct: 2607 LKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEEL---- 2662
Query: 2291 QSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQG-LKRELQVLRLANH 2349
+ K+ K+ E E K+ K + L I+++ E AE L R+L +
Sbjct: 2663 --VCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLL 2720
Query: 2350 QLDKEKAELIHQIEA-NKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEE--I 2406
+ KE L QI++ + S +++ D E++ +L+ + S E LKE+ +
Sbjct: 2721 MVTKENKGLTAQIQSFGRSMSSLQNS---RDHANEELDELKRKYDASLKELAQLKEQGLL 2777
Query: 2407 KKLKKELENFDPSFFEEIEDLKYNYKEEVKKNIL-LEEKVKKLSEQL 2452
+ + L + E+ ++ E++ + +L +E++ LS QL
Sbjct: 2778 NRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824
Score = 124 bits (311), Expect = 1e-27
Identities = 215/1061 (20%), Positives = 443/1061 (41%), Gaps = 198/1061 (18%)
Query: 1535 LKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADS 1594
L A Q + ++ + QK+ L++ L++ R+ +KK + LH + +L +
Sbjct: 54 LAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLK-----LHAKAKL---T 105
Query: 1595 SLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQ 1654
SLNK+ + ++ Q T +PT + E+ +++ D S + ++++K+ L+ +
Sbjct: 106 SLNKYIE---EMKAQGGTVLPTE------PQSEEQLSKHDKSSTEEEMEIEKIKHKLQEK 156
Query: 1655 REI------------------TELKVKEFENIKLQLQEN--------------------- 1675
E+ + +++EF +K QLQE
Sbjct: 157 EELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQ 216
Query: 1676 ----------------HEDEVKK------VKAEVEDLKYLLDQSQKESQ----------- 1702
HEDE+ + V+ E++ +L + +E +
Sbjct: 217 QVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVD 276
Query: 1703 CLKSELQAQKEANS---------RAPTTTMRNLV--ERLKSQLALKEKQQKALSRALL-- 1749
L+ EL A ++ N A T+RN V ER +S++ L++ + + R L
Sbjct: 277 LLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFH 336
Query: 1750 ELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSK 1809
L+ EM E+ + +Q E + +H K ++E+ ++L L+ KT +
Sbjct: 337 NLQEEMHHLLEQFEQAGQAQAELESRYSALEQKH----KAEMEEKTSHILSLQ---KTGQ 389
Query: 1810 NRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPL--- 1866
+ S D L D N++L Q + ++ + I Q D+L+++ K ++ L PL
Sbjct: 390 ELQ-SACDALKDQNSKL--LQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQH 446
Query: 1867 ------------TDNKQSLIEE----LQRKVKKLENQLEG-KVEEVDLKPMKEKNAKEEL 1909
+ Q++ EE LQ++V +LEN+ + ++L+ +K +N K
Sbjct: 447 ETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEK--- 503
Query: 1910 IRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGM 1969
Q + +N+ E + EV +++ + ++ + + Q L+ T
Sbjct: 504 ------LSSQITLLEAQNRTGEADREV----SEISIVDIANKRSSSAEESGQDVLENTFS 553
Query: 1970 TVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSV--VEDLHLQNRYLQE 2027
+ L + LE ++ EE+ L L+ H+ L + + +E + ++
Sbjct: 554 QKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKV 613
Query: 2028 KLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLP 2087
L + F + S+ +E + Q E + L+ +ELK + +K L
Sbjct: 614 FLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLS 673
Query: 2088 RLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRE 2147
+ + + ++ E LK + E++ L + K + E K I + +++E+ ++
Sbjct: 674 AVPDIGQCHQDELERLKSQILELE--LNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKN 731
Query: 2148 NEQLKKASGILTSEKMANIEQENE-----KLKAELEKLKAHLG---HQLSMHYESKTKGT 2199
+ A L+ E+ + Q E +L+A++++L+ +L Q + YES+T
Sbjct: 732 ADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHD 791
Query: 2200 EKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLE 2259
+ + L E K + E L+ +++++ + + + +LQ ES LE
Sbjct: 792 NLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESE--VLE 849
Query: 2260 GADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQ 2319
GA+ R +K++EL +++K IT + QL+ E + + + E+ +Q
Sbjct: 850 GAER--------VRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQ 901
Query: 2320 QIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDAD 2379
Q+ + + TE+ + QL++EK L +I+ K+Q S +A
Sbjct: 902 QVTEISF----SMTEKMV------------QLNEEKFSLGVEIKTLKEQLNLLSRAEEAK 945
Query: 2380 QLK-EKIKDLETQLKMS--------DLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYN 2430
+ + E+ ++ + LK + + K+ L+ E LKKE E +++ N
Sbjct: 946 KEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRK----RKLQAALIN 1001
Query: 2431 YKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEE 2471
KE +++ LEE++ L ++ E+ P++ +E E EE+
Sbjct: 1002 RKELLQRVSRLEEELANLKDESKKEI--PLSETERGEVEED 1040
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 265 bits (677), Expect = 4e-70
Identities = 479/2297 (20%), Positives = 987/2297 (42%), Gaps = 336/2297 (14%)
Query: 1 MPPNINWK------EIMKVDPDDLPRQEELADNLLISLSKVEVNE----LKSEKQENVIH 50
+P NI K +++ + + + ++ N L +LS++E N L E E+ ++
Sbjct: 442 IPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELN 501
Query: 51 LFR-------ITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQ 103
R + ++ + +E+EL L+E E +A K + M+L +E+ +
Sbjct: 502 SLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKN 561
Query: 104 SAGGRDT--RFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNE-------- 153
+ + L NE+ + L +K+ +++ +++ ++ +K N ++ L
Sbjct: 562 LVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPK 621
Query: 154 --------------EAENENSKLRRENKRLKKKNEQLC-------QDIIDYQKQIDSQKE 192
+A+ E++ LR EN LK+K ++L DI YQ Q++++K+
Sbjct: 622 QMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKK 681
Query: 193 TLLSRRGEDSDYRSQLSKK--------------NYELIQYLDEIQTLTEANEKIEVQNQE 238
+ E ++++K N EL + ++Q E N+++E +N+
Sbjct: 682 MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQ--KELNKEVE-ENEA 738
Query: 239 MRK------NLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLL 292
+R+ L+ E+E++ E +H + D+L E H + +VQ L L
Sbjct: 739 LREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGL--LE 796
Query: 293 KSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSN--V 350
+ +DD N K S D E ++ + + +K K + ++ N +
Sbjct: 797 EIGKTKDDLATTQSNYK---------STDQEFQNFKTLHMDFEQKYKMVLEENERMNQEI 847
Query: 351 MALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQ 410
+ L + Q+ DS + L ++ T+E+++ T +++ NE+++ L +Q +
Sbjct: 848 VNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQ------LKEQLENRDS 901
Query: 411 STLDILKEK---TKEAERTAELAEADAREKD--KELVEALKRLKDYESGVYGLEDAVVEI 465
+ + +EK T++ ++T E + +EKD K+L E+L+ +D + D V
Sbjct: 902 TLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKS--DIHDTVNMN 959
Query: 466 KNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVG----------------- 508
+ + Q++ ++ + IN L+ KIS+ + N + E G
Sbjct: 960 IDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQ 1019
Query: 509 -LEPKTMIDLT-EFRNSKHLKQQ-------------QYRAENQILLKE------------ 541
LE K LT + ++++ ++QQ Q E+ I KE
Sbjct: 1020 DLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM 1079
Query: 542 -IESLEEERL---DLKKKIRQMAQERG---KRSATSGLTTEDLNLTEN--ISQGDRISER 592
IE+ EE RL +LKK+ +AQE+ K+ T + L E + ++ E+
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 593 KLDLLSL-KNMSEAQSK-NEF--LSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLE 648
+ LL++ + MSE Q K NE L EL KE LE T + KL E EE K +
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSIT 1199
Query: 649 EGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQL 708
+ K +KE+QK + + I R + A + E + A +HLK + +
Sbjct: 1200 KERK----VLKELQKSFETERDHLRGYI----REIEATGLQTKEELKIAHIHLKEHQETI 1251
Query: 709 TGRNEELRQELRESRKEAINYSQQLAKANLKIDH----LEKETSLL---RQSEGSNVVFK 761
+ELR+ + E + IN +Q L K++ K+ L +E LL ++ +
Sbjct: 1252 ----DELRRSVSEKTAQIIN-TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMN 1306
Query: 762 GIDL--PDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNL---EDSLEDYNRKFAVIR 816
++L S ++ + E L L ++ + ++++K+L D+L+ V
Sbjct: 1307 ELELLTEQSTTKDSTTLARIEMERL-RLNEKFQESQEEIKSLTKERDNLKTIKEALEVKH 1365
Query: 817 HQQSLLYKEYLS---EKETWKTESKTIKE---EKRKLEDQVQQ----DAIKVK---EYNN 863
Q +E L+ E ++ + +S +KE E K+ +++Q D+ ++ E
Sbjct: 1366 DQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLG 1425
Query: 864 LLNALQMDSDEMKKILAEN---SRKITVLQVNEKSLIRQYTTLV----ELERQLR----- 911
L LQ DEMK + E R VLQ L +V E E +L+
Sbjct: 1426 LSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCC 1485
Query: 912 -KENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIA-ALQKVVDNSVSLSELELANKQY 969
KE E+ NEL +E +I +Q+ E K+ +Q++ + E + KQ
Sbjct: 1486 LKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYE-----KEEQFNIKQI 1540
Query: 970 NELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEI---TKEKLHTIEQ 1026
+E+ K ++ Q + S L+ +E + + L +++ +E++I KE++ +++
Sbjct: 1541 SEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQE 1600
Query: 1027 AWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQ----RAEHCQKMYEH 1082
A + E + + K I S K+ L+M +NE Q EH ++ +E
Sbjct: 1601 ALQIE-----RDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFET 1655
Query: 1083 LRTSLKQMEERNFELE-------TKFAELTKINLDAQKVEQML---RDELADSVSKAVSD 1132
+ +L+ +E N L + +TK D + VE+ L RD+L +++ + ++
Sbjct: 1656 QKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETIT- 1714
Query: 1133 ADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQA 1192
D ++ EL+ M LK + ++ I + ++ Q+ + ++L+ Q L Q
Sbjct: 1715 RDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ- 1773
Query: 1193 QSDEKSLIAKLH--QHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDE---KEQ 1247
E+ IA +H + ++ K + +++ + +E N +L++K+ E E
Sbjct: 1774 ---EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEH 1830
Query: 1248 ALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNS 1307
L + + K + + Q ++ +L L++ E + + Q ++ L +EMK+
Sbjct: 1831 QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENL---EEMKSV 1887
Query: 1308 QQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVK 1367
+E N+ + +E LKL+ ++L +L++TK I QELK R L K
Sbjct: 1888 MKERDNL--RRVEETLKLE-RDQLKESLQETKARDLEIQ----------QELKTARMLSK 1934
Query: 1368 D-KEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLER---QLDIFDR 1423
+ KE + L ISE IS +++++ + +++ ++E+ L R +++ +
Sbjct: 1935 EHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHK 1994
Query: 1424 QQNEILNAAQKFEEATGSIPDPSLPLPN-QLEIALRKIKENIRIILETRATCKSLEEKLK 1482
+ NE+ ++FE S+ S+ + N QL L + E IRI+ + R + ++E LK
Sbjct: 1995 KINEMEQLKKQFEAQNLSM--QSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLK 2052
Query: 1483 EKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKE----MEPKSHHTLKIA 1538
+ + +++RD+ ++++ ++ ++ + E R++ E ++
Sbjct: 2053 MERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDD 2112
Query: 1539 HQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNK 1598
H N + +KE +K + KA + KH E L + R ++ + K
Sbjct: 2113 HYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKK 2172
Query: 1599 FKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLE-RQREI 1657
K + T + +H + + E ++ + LL+K++ + QD + RE+
Sbjct: 2173 LK-----YVLSYVTKIKEEQH-ESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSREL 2226
Query: 1658 TELKVKEFENIKLQ--LQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEAN 1715
+LK+ + ++ ++ L++ E E +K E + +L ++ +Q L+ L N
Sbjct: 2227 RDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQ---VLSNRKEMTQFLEEWL------N 2277
Query: 1716 SRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLN 1775
+R ++N +++ ++ + + ++ + E T E SAT KE +
Sbjct: 2278 TRFDIEKLKNGIQKENDRIC---QVNNFFNNRIIAIMNESTEFEER---SATISKEWEQD 2331
Query: 1776 VQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENS---------LTDNLNDLNNEL 1826
++ + +++ + K + L +L + T+++ +N T+ + +L N L
Sbjct: 2332 LKSLKEKNEKLFK-NYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSL 2390
Query: 1827 QKKQKA----YNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVK 1882
+ +++ +KI++ ++E++ ND + + LQ K NK +E+ + ++
Sbjct: 2391 HEAKESAMHKESKIIKMQKELEVTND--------IIAKLQAKVHESNK--CLEKTKETIQ 2440
Query: 1883 KLENQ--LEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLT 1940
L+++ L K + +++ +K K K +L + + K+++ +I + ++ ++ + L
Sbjct: 2441 VLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLR 2500
Query: 1941 KQL---NTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKR--NLD 1995
+ L +D ++ K T G V +AL + E L+K L
Sbjct: 2501 ENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLK 2560
Query: 1996 LENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSK-----DTYSKPSISGIE 2050
+N+ L + ++ L + HL N K L+++ K ++ P ++G
Sbjct: 2561 QQNEQLIKQKNELLSNNQ-----HLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTA 2615
Query: 2051 SDDHCQREQELQKENLK 2067
S + ++ NL+
Sbjct: 2616 SKKKQITPSQCKERNLQ 2632
Score = 261 bits (667), Expect = 6e-69
Identities = 499/2416 (20%), Positives = 1028/2416 (42%), Gaps = 405/2416 (16%)
Query: 114 RNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLAL----RNEEAEN--------ENSK 161
R EI L+KQLE+ E E ++ ++ E+ L +NE+ EN +
Sbjct: 349 RKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLT 408
Query: 162 LRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDE 221
L++E K +K+ C I+ K S + + + ++ K ++L
Sbjct: 409 LQQELKAKRKRRVTWCLGKINKMKN---------SNYADQFNIPTNITTKTHKL-----S 454
Query: 222 IQTLTEANEKIEVQNQ----------EMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVI 271
I L E +E + ++ E+ N + E + E N ++A DN++
Sbjct: 455 INLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRA---DYDNLV 511
Query: 272 ---DQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQ 328
+QL+ E + +L+ LK KN+ D+ A+ K +K D+ ++
Sbjct: 512 LDYEQLRTEKEEMELK-------LKEKNDLDE--FEALERK---------TKKDQEMQLI 553
Query: 329 QMLHNLREKLKNAQL-DADKSNVMALQ-QGIQERDSQIKMLTEQV-----EQYTKEMEKN 381
+ NL+ +K+A++ + D N ++ + + ++E++ QIK L E + E ++ +
Sbjct: 554 HEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYS 613
Query: 382 TCIIEDLKNELQRNKGASTLSQQTHMK---IQSTLDILKEKTKEAERTAELAEADAREKD 438
IED K Q A T++ + ++S LKEK KE T + E D +
Sbjct: 614 LESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQ 673
Query: 439 KELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEI-LTKEINKLELKISDFL 497
+L K D E + + + ++ + + +D + L +I L+ +++ +
Sbjct: 674 SQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEV 733
Query: 498 DENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIR 557
+ENEALRE V ILL E++SL E L+K+I+
Sbjct: 734 EENEALREEV-----------------------------ILLSELKSLPSEVERLRKEIQ 764
Query: 558 QMAQERGKRSATSGLTTEDLNLTENISQG--DRISERKLDLLSLKNMSEAQSKNEFLSRE 615
++E ++ ++ E+ QG + I + K DL A +++ + S +
Sbjct: 765 DKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDL--------ATTQSNYKSTD 816
Query: 616 LIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLI 675
++ + +T+ F+ K K ++EEN+++ + EI+ KE QK
Sbjct: 817 -----QEFQNFKTLHMDFEQKYKMVLEENERMNQ---EIVNLSKEAQK------------ 856
Query: 676 IPSLERLVNAIESKNAEGIFDASLH-LKAQVDQLTGRNEELRQELRESRKEAINYSQQLA 734
FD+SL LK ++ T +E +E++E E +QL
Sbjct: 857 -------------------FDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLE 897
Query: 735 KANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENK 794
+ + +E+E +L+ + + + + + L L + L+ +
Sbjct: 898 NRDSTLQTVEREKTLITEKLQQTL-------------EEVKTLTQEKDDLKQLQESLQIE 944
Query: 795 EKKLK---------NLEDSLEDYNRKFAVIRHQQSL-LYKEYLSEKETWKTESKTIKEEK 844
+LK N++ + N ++ +HQ+++ K +SE+ + + ++E
Sbjct: 945 RDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVS---RNLHMEENT 1001
Query: 845 RKLEDQVQQDAIKVKEYNNL--LNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTT 902
+ +D+ QQ + + + +L N + +D + E RKI L + EK+ ++Q
Sbjct: 1002 GETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSL-IQEKNELQQMLE 1060
Query: 903 LVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSEL 962
V E++ K + K+ E+ E +G ++ Q++V E
Sbjct: 1061 SVIAEKEQLKTDLKENIEMTIENQEELRLLGD----------ELKKQQEIV-----AQEK 1105
Query: 963 ELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINK---ELEITKE 1019
A K+ EL+ + + + L +++ L+ + + ++++E++ + K E+E K
Sbjct: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKN 1165
Query: 1020 KLHTIEQAWEQ-ETKLGNESSMDKAKKSITN-SDIVSISKKITMLEMKELNERQRAEHCQ 1077
+L E E ET+ ++ A+K N ++ SI+K E K L E Q++ +
Sbjct: 1166 ELKNKELTLEHMETE-----RLELAQKLNENYEEVKSITK-----ERKVLKELQKSFETE 1215
Query: 1078 KMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQR 1137
+ +HLR ++++E L+TK E KI K Q DEL SVS+ + +
Sbjct: 1216 R--DHLRGYIREIEATG--LQTK--EELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269
Query: 1138 ILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEK 1197
+LEK+ +L+ E+ L E ++ E+ Q+ + ++LL Q+ + +
Sbjct: 1270 --DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNE-------LELLTEQSTTKDS 1320
Query: 1198 SLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGR 1257
+ +A++ + L + +++S+T + ++ LE K D+ ++ + + +
Sbjct: 1321 TTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ 1380
Query: 1258 NRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENK 1317
Q++ + +++ E+F L +++++ K Q+ H M++
Sbjct: 1381 ESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSV 1440
Query: 1318 TLEMELKLKGLEELISTLKDT--KGAQKVINWHMKIEELRLQELKLNRELVKDKEE-IKY 1374
E + L+ L+E++ + D + ++++ H++ EE ELK+ +K++EE I
Sbjct: 1441 AKEKD-DLQRLQEVLQSESDQLKENIKEIVAKHLETEE----ELKVAHCCLKEQEETINE 1495
Query: 1375 LNNIISEYERTISSLEEEIVQQN-KFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQ 1433
L +SE E IS++++++ N K + Q +++ E +Q+ + NE+ +
Sbjct: 1496 LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKE 1555
Query: 1434 KF---EEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRL 1490
+ A SI L L N+L+ + +E I+I+++ + K ++E L+ + L+
Sbjct: 1556 HRKAKDSALQSIESKMLELTNRLQ----ESQEEIQIMIKEKEEMKRVQEALQIERDQLKE 1611
Query: 1491 AEQNILSRDKVINELR---LRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQA 1547
+ I+++ K E L++ A E ++ + E+ E + T K+ + I
Sbjct: 1612 NTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEI---EHLKEQFETQKLNLENIETENI 1668
Query: 1548 RLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAW-DL 1606
RL Q +L + EE R + K+ + DL + L+++ D ++T DL
Sbjct: 1669 RLTQ----------ILHENLEEMRSVTKERD-DLRSVEETLKVERDQLKENLRETITRDL 1717
Query: 1607 MKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREIT---ELKVK 1663
KQ + + L E ++T+ + +S ++ + +DLE + +LK++
Sbjct: 1718 EKQEELKIV----HMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ 1773
Query: 1664 EFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQA---QKEANSRAPT 1720
E I + ++ + K++ V + L QK+ + ++LQ + +AN
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833
Query: 1721 TTMRNLVERLK--SQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ 1778
T +++ E K S++ +KQ K S L +L E +LN+ Q
Sbjct: 1834 TLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIE------------------NLNLAQ 1875
Query: 1779 IVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILR 1838
+ + E+K+ +++ +NL +++E LK +++ + E+Q++ K + +
Sbjct: 1876 KLHENLEEMKSVMKE-RDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSK 1934
Query: 1839 EKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLK 1898
E +E D+L+ +I K I ++Q+ + K +++L+ K++E+ K
Sbjct: 1935 EHKETV---DKLREKISE-------------KTIQISDIQKDLDKSKDELQKKIQELQKK 1978
Query: 1899 PMKEKNAKEELI----RWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKAD 1954
++ KE++ + E ++ + + E ++ + F LTK+L+ +
Sbjct: 1979 ELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVA 2038
Query: 1955 KEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSV 2014
KE+ L+R ++ M DQ + L E+ R D +N HQ P +
Sbjct: 2039 KERDELRRIKESLKMERDQFIAT--------LREMIAR--DRQN-------HQVKPEKRL 2081
Query: 2015 VED--LHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSEN 2072
+ D HL L+EK +++ + YS E DDH + L + K
Sbjct: 2082 LSDGQQHLTES-LREKCSRIKELLKR--YS-------EMDDHYECLNRLSLDLEK----- 2126
Query: 2073 IELKFQLE-----QANKDLPRLKNQ-VRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKT 2126
E++FQ E +AN LP L+ + + L + E + +KL +V K
Sbjct: 2127 -EIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE 2185
Query: 2127 IPELEKTIGLMKK-VVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG 2185
E ++I + +++V+++ E L K + +++Q+ + EL LK L
Sbjct: 2186 --EQHESINKFEMDFIDEVEKQKELLIK---------IQHLQQDCDVPSRELRDLK--LN 2232
Query: 2186 HQLSMHYESKTKGTEK-----IIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQ 2240
+ +H E K + I E +++ K+ T E+ + ++E L + +
Sbjct: 2233 QNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKE 2292
Query: 2241 LEETGKRLQFAESRGPQLEGADSK-SWKSIVVTRMYETKLKELETDIAKKNQSITDLKQL 2299
+ + F +R + ++ +S +++ +E LK L+ +KN+ + Q
Sbjct: 2293 NDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLK----EKNEKLFKNYQT 2348
Query: 2300 VKEATEREQKVNKYNEDLE-------------QQIKILKHVPEGAETEQGLKRELQVLRL 2346
+K + +VN +D + ++I+ L++ A+ E + +E +++++
Sbjct: 2349 LKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAK-ESAMHKESKIIKM 2407
Query: 2347 ------ANHQLDKEKAELIHQIEANKDQSGAESTIP--------DADQLKEKIKDLETQL 2392
N + K +A+ +H E+NK + TI A KE+I+DL+ +L
Sbjct: 2408 QKELEVTNDIIAKLQAK-VH--ESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKL 2464
Query: 2393 KMSDLEKQHLKEEIKK 2408
DLEK +E +K
Sbjct: 2465 VKIDLEKMKNAKEFEK 2480
Score = 245 bits (626), Expect = 3e-64
Identities = 462/2395 (19%), Positives = 1005/2395 (41%), Gaps = 407/2395 (16%)
Query: 98 LEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEE--- 154
L+ A + ++T ++ NE+ E L++ +E+ D++K+LE+ A+ ++
Sbjct: 320 LQFASTAKYMKNTPYV-NEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQ 378
Query: 155 -AENENSKLRRENKRLKKKNEQL-CQDIIDYQKQIDSQKETLLS------RRGEDSDYRS 206
E ++ + +N++++ L + Q+++ ++++ ++ + ++S+Y
Sbjct: 379 LLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYAD 438
Query: 207 QLS----------KKNYELIQYLDE------------IQTLTEA----------NEKIEV 234
Q + K + L++ +DE + TL+E E IE
Sbjct: 439 QFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIES 498
Query: 235 QNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNV-----IDQLKKENDHYQL--QVQE 287
+ +R + + V + E++ E M+ + + +++ +++ K++ QL ++
Sbjct: 499 ELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISN 558
Query: 288 LTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQ-----QMLHNLR------- 335
L +L+K + + +++KVE +L K+D+I + Q Q L N++
Sbjct: 559 LKNLVKHAEVYNQDLENELSSKVE----LLREKEDQIKKLQEYIDSQKLENIKMDLSYSL 614
Query: 336 ------EKLKNAQLDAD-------------KSNVMALQQGIQERDSQIKMLTEQVEQYTK 376
+++K DA+ +S + L++ ++E + K + ++ Y
Sbjct: 615 ESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQS 674
Query: 377 EMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADARE 436
++E + DL+ ELQ S ++ T K+ S +D K E D ++
Sbjct: 675 QLEAKKKMQVDLEKELQ-----SAFNEIT--KLTSLIDGKVPKDLLCNLELEGKITDLQK 727
Query: 437 KDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDF 496
+ + VE + L++ + L+ E++ + +I+ + E+ I+T E +KL ++
Sbjct: 728 ELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHK 787
Query: 497 LDENEALRERVGLEPKTMIDLT-----------EFRNSKHLKQQQYRAENQILLKEIESL 545
+ L E +G KT DL EF+N K L + + +++L+E E +
Sbjct: 788 ESRVQGLLEEIG---KTKDDLATTQSNYKSTDQEFQNFKTL-HMDFEQKYKMVLEENERM 843
Query: 546 EEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR-ISERKLDLLSLKNMSE 604
+E ++L K+ ++ S+ L TE T+ + + R + ER ++ LK
Sbjct: 844 NQEIVNLSKEAQKF------DSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKE--- 894
Query: 605 AQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKD 664
Q +N + + +E+E+ L KL++ +EE K L + ++ Q + +Q +
Sbjct: 895 -QLENRDSTLQTVEREKTL---------ITEKLQQTLEEVKTLTQEKDDLKQLQESLQIE 944
Query: 665 PDVKGGE----TSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELR 720
D + ++ I + E+L NA+ES + LK+++ + RN + +
Sbjct: 945 RDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQ--ETINTLKSKISEEVSRNLHMEENTG 1002
Query: 721 ESRKEAINYSQQLAKANLKIDHLEKETSLLRQS-------EGSNVVFKGIDLPDGIAPSS 773
E++ E + Q++ + K D K T L E +F I + +
Sbjct: 1003 ETKDE---FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQML 1059
Query: 774 ASIINSQNEYLIHLLQELE---NKEKKLKNLEDSLED------YNRKFAVIRHQQSLLYK 824
S+I + + L + +E +++L+ L D L+ + A+ + +
Sbjct: 1060 ESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTC 1119
Query: 825 EYLSE-KETWKTESKTIKEEKRKL---EDQVQQDAIKVKEYNNLLNAL---QMDSDEMKK 877
+ L+E +E K +S+ ++E++++L ++++ + K+ E NL N L ++ + M+
Sbjct: 1120 DRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMET 1179
Query: 878 ILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQR 937
E ++K+ KS+ ++ L EL++ E + + + +EA LQ
Sbjct: 1180 ERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEAT------GLQT 1233
Query: 938 FKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLE 997
+E+ I I + ++ ++ EL R + +K ++ N + LE
Sbjct: 1234 KEELKIAHI----HLKEHQETIDELR-------------RSVSEKTAQII----NTQDLE 1272
Query: 998 CENISLKEQVESINKELEI---------TKEKLHTIEQAWEQET--------KLGNESSM 1040
+ L+E++ +++E E+ T+E ++ +E EQ T ++ E
Sbjct: 1273 KSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLR 1332
Query: 1041 DKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETK 1100
K + +I S++K+ +K + E +H Q + EH+R +L +++E + E
Sbjct: 1333 LNEKFQESQEEIKSLTKERD--NLKTIKEALEVKHDQ-LKEHIRETLAKIQESQSKQEQS 1389
Query: 1101 FAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISD 1160
K N + V +M + + DS + +L L K E E+ + + D
Sbjct: 1390 LNMKEKDNETTKIVSEMEQFKPKDSALLRI----EIEMLGLSKRLQESHDEMKSVAKEKD 1445
Query: 1161 IARRQVEILNAQQQSRDKEVESLRMQLLDYQAQ--------SDEKSLIAKLHQHNVSLQL 1212
+R E+L ++ + ++ + + L+ + + +++ I +L + +
Sbjct: 1446 DLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKET 1505
Query: 1213 SEATALGKLESITSKLQ--------KMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLR 1264
+T +LE+I KLQ K E +N++ ++ EK L + E R
Sbjct: 1506 EISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFK-EHRKAKDSAL 1564
Query: 1265 QTIQSLRRQFSGALPLAQQE-----------KFSKTMIQLQNDKLK-----IMQEMKNSQ 1308
Q+I+S + + L +Q+E K + +Q++ D+LK I+ +MK SQ
Sbjct: 1565 QSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQ 1624
Query: 1309 QEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRL-----QELKLNR 1363
++ T E + K E I LK+ QK+ +++ E +RL + L+ R
Sbjct: 1625 EKEYQFLKMTAVNETQEKMCE--IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMR 1682
Query: 1364 ELVKDKEEIKYLNNIIS-EYERTISSLEEEIVQQNKFHEERQ---MAWDQREVDLERQLD 1419
+ K++++++ + + E ++ +L E I + + EE + M + + +++
Sbjct: 1683 SVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRG 1742
Query: 1420 IFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATC----- 1474
I + NEI N + E + ++ L + +L IA +KE I + R
Sbjct: 1743 IVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTD 1802
Query: 1475 ------KSLEE---KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAE--LG 1523
K LE KL+EK L+ E +++ K +NE + ++ + +K I + L
Sbjct: 1803 KLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLT 1862
Query: 1524 RKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHE-EDLH 1582
++E ++ + + H+ + M++ + +++ L++ + L+ R++ +E +++ + DL
Sbjct: 1863 LSKLEIENLNLAQKLHENLEEMKSVMKERDN-LRRVEETLKLERDQLKESLQETKARDLE 1921
Query: 1583 ILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLV 1642
I + EL+ L+K + D +++ ++ I+++++++ + + D L +
Sbjct: 1922 I---QQELKTARMLSKEHKETVDKLREK-----ISEKTIQISDIQKDLDKSKDELQKKIQ 1973
Query: 1643 KLKKVSQDLERQRE---ITELKVKEFENIKLQLQEN------------------HE--DE 1679
+L+K L R +E ++ K+ E E +K Q + HE +E
Sbjct: 1974 ELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEE 2033
Query: 1680 VKKVKAEVEDLKYLLDQSQKESQ----CLKSELQAQKEANSRAP------------TTTM 1723
++ V E ++L+ + + + E L+ + ++ + P T ++
Sbjct: 2034 IRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESL 2093
Query: 1724 RNLVERLKSQL---ALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIV 1780
R R+K L + + + L+R L+L E+ E + + +A+L++ +
Sbjct: 2094 REKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKE-----LSMRVKANLSLPYLQ 2148
Query: 1781 DRHTRELKTQVE----DLNENLLKLKEAL----KTSKNRENSLTDNLNDLNNELQKKQKA 1832
+H +L T + + + + KLK L K + + S+ D +E++K+++
Sbjct: 2149 TKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKEL 2208
Query: 1833 YNKILREKEEIDQENDELK------------RQIKRLTSGLQGKPLTDNKQSLIEELQRK 1880
KI +++ D + EL+ +I + S + + Q ++ +
Sbjct: 2209 LIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEM 2268
Query: 1881 VKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLT 1940
+ LE L + D++ +K KE + + +I I N+ E E T++
Sbjct: 2269 TQFLEEWLNTR---FDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATIS 2325
Query: 1941 KQ----LNTLKDLFAKADKEKLTLQRKLKTTGMT---------------VDQVLGIRALE 1981
K+ L +LK+ K K TL+ L + Q+ + E
Sbjct: 2326 KEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRE 2385
Query: 1982 SEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTY 2041
E L E K+ + E+ I+ M+ + D + + LQ K+H K K
Sbjct: 2386 LENSLHEAKESAMHKESKIIKMQKELEVTNDIIAK--------LQAKVHESNKCLEKTKE 2437
Query: 2042 SKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCE 2101
+ + + ++E++ +KL ++E ++ K++ K V KE+
Sbjct: 2438 TIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIR 2497
Query: 2102 FLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLK--KASGILT 2159
L++ ++R S ++ T E T Q N+ L SGI+
Sbjct: 2498 LLRE----------NLRRSQQAQDTSVISEHT---------DPQPSNKPLTCGGGSGIVQ 2538
Query: 2160 SEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELK 2214
+ K ++ E+ +L+ E+ KLK E K ++++ N+ L E+K
Sbjct: 2539 NTKALILKSEHIRLEKEISKLK--------QQNEQLIKQKNELLSNNQHLSNEVK 2585
Score = 213 bits (542), Expect = 2e-54
Identities = 480/2306 (20%), Positives = 978/2306 (42%), Gaps = 334/2306 (14%)
Query: 299 DDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQ 358
+D + V A + ++ I D E + + E + + K + +++ +
Sbjct: 100 EDHLGVIPRAIHDIFQKIKKFPDREFLLRVSYMEIYNETITDLLCGTQKMKPLIIREDVN 159
Query: 359 ERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKE 418
R+ + LTE+V YT EM K E R+ G + ++Q++ IL+
Sbjct: 160 -RNVYVADLTEEVV-YTSEMALKWIT----KGEKSRHYGETKMNQRSSRSHTIFRMILES 213
Query: 419 KTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDRE 478
+ K E + LV+ + ++G G V +K N +R
Sbjct: 214 REKGEPSNCE---GSVKVSHLNLVDLAGSERAAQTGAAG-----VRLKEGCNI----NRS 261
Query: 479 IEILTKEINKL-ELKISDFLDENEA-----LRERVGLEPKTMIDLT-------------E 519
+ IL + I KL + ++ F++ ++ L+ +G KT I T +
Sbjct: 262 LFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPVSFDETLTALQ 321
Query: 520 FRNS-KHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLN 578
F ++ K++K Y E ++ +E +DLKK++ +++ E T E
Sbjct: 322 FASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLE------TRAQAMEKDQ 375
Query: 579 LTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLK 638
L + + + D + +K+ ++N++ + L+ + K + R + K NK+K
Sbjct: 376 LAQLLEEKDLL--QKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKI-NKMK 432
Query: 639 E---LVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVN-----AIESKN 690
+ N K +I +++ + E+ + +L+ L A + N
Sbjct: 433 NSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLN 492
Query: 691 AEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLL 750
E I L+A D L E+LR E E + K +D E
Sbjct: 493 QENIESELNSLRADYDNLVLDYEQLRTEKEEMELK--------LKEKNDLDEFEALERKT 544
Query: 751 RQSEGSNVVFKGIDLPDGIAPSSASIINSQNEY--LIHLLQELENKEKKLKNLEDSLEDY 808
++ + ++ + +L + + + + +NE + LL+E E++ KKL+ DS +
Sbjct: 545 KKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLE 604
Query: 809 NRKFAVIRHQQSL----LYKEYLSEKET----WKTESKTIKEEKRKLEDQVQQDAIKVKE 860
N K + +S+ K+ L + ET K ES ++ E +L++++++ A K+
Sbjct: 605 NIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQ 664
Query: 861 YNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNE 920
N + Q + KK+ + +++ +S + T L L + + K+
Sbjct: 665 MENDIQLYQSQLEAKKKMQVDLEKEL-------QSAFNEITKLTSL-----IDGKVPKDL 712
Query: 921 LLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDIL 980
L ++E E KI LQ+ + + AL++ V + LSEL+ + L ++I
Sbjct: 713 LCNLELE--GKITDLQKELNKEVEENEALREEV---ILLSELKSLPSEVERLR---KEIQ 764
Query: 981 QKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIE---QAWEQETKLGNE 1037
K L TS + L E + + +V+ + +E+ TK+ L T + ++ +QE +
Sbjct: 765 DKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT 824
Query: 1038 SSMDKAKK--------SITNSDIVSISKKI----TMLEMKELNERQRAEHCQKMYEHLRT 1085
MD +K N +IV++SK+ + L + + + Q+ ++
Sbjct: 825 LHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQE 884
Query: 1086 SLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNE 1145
L +ME+ +LE + + L + + + + L+ L + V + D +L++ +
Sbjct: 885 RLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTL-EEVKTLTQEKD-----DLKQLQ 938
Query: 1146 MELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQ 1205
L++E +L+ SDI ++ Q+Q R+ +ESL+ Q Q +L +K+ +
Sbjct: 939 ESLQIERDQLK--SDIHDTVNMNIDTQEQLRN-ALESLK------QHQETINTLKSKISE 989
Query: 1206 H-NVSLQLSEATALGKLESI-----TSKLQKMEAYN---LRLEQKLDE--KEQALYYARL 1254
+ +L + E T K E K Q +EA N L + K +E ++Q ++ +
Sbjct: 990 EVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLI 1049
Query: 1255 EGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTM-----IQLQNDKLKIMQEMKNSQQ 1309
+ +N + + +++ + + Q L +E T+ ++L D+LK QE+ Q
Sbjct: 1050 QEKNELQQMLESVIAEKEQLKTDL----KENIEMTIENQEELRLLGDELKKQQEI--VAQ 1103
Query: 1310 EHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNR---ELV 1366
E + K E+ L E+ LK+ +++E + Q L + E+
Sbjct: 1104 EKNHAIKKEGELSRTCDRLAEVEEKLKEKS---------QQLQEKQQQLLNVQEEMSEMQ 1154
Query: 1367 KDKEEIKYLNNIISEYERTISSLEEEIVQ----QNKFHEERQMAWDQREVDLERQLDIFD 1422
K EI+ L N + E T+ +E E ++ N+ +EE + +R+V E Q F+
Sbjct: 1155 KKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKS-FE 1213
Query: 1423 RQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLK 1482
+++ + ++ EATG L +L+IA +KE+ I E R +S+ EK
Sbjct: 1214 TERDHLRGYIREI-EATG------LQTKEELKIAHIHLKEHQETIDELR---RSVSEK-- 1261
Query: 1483 EKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTI 1542
+A + Q++ +K +L+ +P E ++L+ + ++ + L++ +
Sbjct: 1262 ---TAQIINTQDL---EKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQS 1315
Query: 1543 ANMQARLNQKEEVLKKYQRLLEKAREEQREI--VKKHEEDLHILHHRLELQADSSLNKFK 1600
+ + E+ + RL EK +E Q EI + K ++L + LE++ D +
Sbjct: 1316 TTKDSTTLARIEM--ERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIR 1373
Query: 1601 QTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLV--KLKKVSQDLE--RQRE 1656
+T LA+++++ ++Q+ SL+ + K+ ++E + ++
Sbjct: 1374 ET--------------------LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKD 1413
Query: 1657 ITELKVK-EFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLK--------SE 1707
L+++ E + +LQE+H DE+K V E +DL+ L + Q ES LK
Sbjct: 1414 SALLRIEIEMLGLSKRLQESH-DEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 1708 LQAQKEAN-SRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISA 1766
L+ ++E + + L+ L+ KE + + + L + ++ + I
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKL-----QNKIQE 1527
Query: 1767 TSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNEL 1826
+KE N++QI ++V++ L + KE K + S+ + +L N L
Sbjct: 1528 IYEKEEQFNIKQI---------SEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRL 1578
Query: 1827 QKKQKAYNKILREKEEIDQ-------ENDELKRQIKRLTSGL---QGKPLTDNKQSLIEE 1876
Q+ Q+ +++EKEE+ + E D+LK K + + + Q K K + + E
Sbjct: 1579 QESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNE 1638
Query: 1877 LQRKVKKLENQLEG-KVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKE-- 1933
Q K+ ++E+ E + ++++L+ ++ +N + I E +E +R+ KE++
Sbjct: 1639 TQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHE-------NLEEMRSVTKERDDL 1691
Query: 1934 -GEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGM-------TVDQVLGIRALESEKE 1985
TL + + LK+ + L Q +LK M T+D++ GI E E
Sbjct: 1692 RSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGI-VSEKTNE 1750
Query: 1986 LEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPS 2045
+ ++K DLE+ ++A + E+L + + +L+E+ ++K
Sbjct: 1751 ISNMQK---DLEHSNDALKAQDL----KIQEELRIAHMHLKEQQETIDK--------LRG 1795
Query: 2046 ISGIESDDHCQREQELQKENLKLSSENIELK---FQLEQANKDLPRLKNQVRDLKEMCEF 2102
I ++D +++L+ N KL + ELK QL KD+ + +V +++++ +
Sbjct: 1796 IVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQ 1855
Query: 2103 LKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMK------KVVEKVQRENEQLKKASG 2156
+K + + + + + K LE+ +MK +V E ++ E +QLK++
Sbjct: 1856 IKDQSLTLSKL--EIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKES-- 1911
Query: 2157 ILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAEN---ERLRKEL 2213
L K ++E + E A + + H E+ K EKI + ++K+L
Sbjct: 1912 -LQETKARDLEIQQELKTARMLSKE---------HKETVDKLREKISEKTIQISDIQKDL 1961
Query: 2214 KKETDAAEK--LRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSI-- 2269
K D +K + K L++L K V + K++ E Q E A + S +S+
Sbjct: 1962 DKSKDELQKKIQELQKKELQLLRVKEDVNMSH--KKINEMEQLKKQFE-AQNLSMQSVRM 2018
Query: 2270 ---VVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKV---------NKYNEDL 2317
+T+ L+E+ +AK+ + +K+ +K ER+Q + ++ N +
Sbjct: 2019 DNFQLTKKLHESLEEIRI-VAKERDELRRIKESLK--MERDQFIATLREMIARDRQNHQV 2075
Query: 2318 EQQIKIL----KHVPEGAETEQGLKREL--QVLRLANHQ--LDKEKAELIHQIEANKDQS 2369
+ + ++L +H+ E + +EL + + +H L++ +L +IE K+ S
Sbjct: 2076 KPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELS 2135
Query: 2370 GAESTIPDADQLKEK-IKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLK 2428
L+ K I+ L T + +E + +++K + + E I +
Sbjct: 2136 MRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFE 2195
Query: 2429 YNYKEEVKKNILLEEKVKKLSEQLGV 2454
++ +EV+K L K++ L + V
Sbjct: 2196 MDFIDEVEKQKELLIKIQHLQQDCDV 2221
Score = 134 bits (336), Expect = 1e-30
Identities = 293/1400 (20%), Positives = 581/1400 (41%), Gaps = 230/1400 (16%)
Query: 1178 KEVESLRMQL----LDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEA 1233
KE+ L+ QL L+ +AQ+ EK +A+L + LQ + K+E++T L +
Sbjct: 350 KEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNE---KIENLTRMLVTSSS 406
Query: 1234 YNLRLEQKLDEKEQALYYA----RLEGRNRAKHLRQTIQSLRRQFSGALPLAQQ-EKFSK 1288
L+ E K K + + +++ N A + ++ L ++ ++
Sbjct: 407 LTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVC 466
Query: 1289 TMIQLQNDKLKIMQEMK-NSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINW 1347
+ + ++ L + E++ N + N EN E+ + L+ + + ++ +
Sbjct: 467 SESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMEL 526
Query: 1348 HMKIEELRLQELK-LNRELVKDKE-----EIKYLNNIISEYERTISSLEEEIVQQNKFHE 1401
+K E+ L E + L R+ KD+E EI L N++ E LE E+ + +
Sbjct: 527 KLK-EKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLR 585
Query: 1402 ERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLE---IALR 1458
E++ DQ +++ + D Q+ E N + SI DP + +AL
Sbjct: 586 EKE---DQ----IKKLQEYIDSQKLE--NIKMDLSYSLESIEDPKQMKQTLFDAETVALD 636
Query: 1459 KIKENIRII---LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLP-ATAE 1514
+E+ + LE + K L K+ E+ ++L + + ++ K+ +L L A E
Sbjct: 637 AKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNE 696
Query: 1515 REKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLN---QKEEVLKKYQRLLEKAR---- 1567
KL + + K PK I ++Q LN ++ E L++ LL + +
Sbjct: 697 ITKLTSLIDGKV--PKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPS 754
Query: 1568 --EEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE 1625
E R+ ++ E+LHI+ + +
Sbjct: 755 EVERLRKEIQDKSEELHIITSEKD-----------------------------------K 779
Query: 1626 MEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKA 1685
+ V ++ + LL ++ K DL + + +EF+N K L + E + K V
Sbjct: 780 LFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT-LHMDFEQKYKMVLE 838
Query: 1686 EVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALS 1745
E E + + KE+Q S L A LK++L+ K ++ + +
Sbjct: 839 ENERMNQEIVNLSKEAQKFDSSLGA-------------------LKTELSYKTQELQEKT 879
Query: 1746 RALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEAL 1805
R + E EM E Q E + Q V+R KT + + KL++ L
Sbjct: 880 REVQERLNEMEQLKE--------QLENRDSTLQTVERE----KTLITE------KLQQTL 921
Query: 1806 KTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKP 1865
+ K +LT +DL + Q +++ + + N + + Q++ L+
Sbjct: 922 EEVK----TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQ 977
Query: 1866 LTDN--KQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIE 1923
T N K + EE+ R + EN G+ ++ + M + K++L E K Q
Sbjct: 978 ETINTLKSKISEEVSRNLHMEENT--GETKDEFQQKMVGIDKKQDL----EAKNTQTLTA 1031
Query: 1924 GIR-NKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTT-GMTVDQVLGIRALE 1981
++ N++ E++ ++F+L ++ N L+ + EK L+ LK MT++ +R L
Sbjct: 1032 DVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLG 1091
Query: 1982 SE-KELEEL--KKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSK 2038
E K+ +E+ +++N ++ + R L V E L +++ LQEK L +
Sbjct: 1092 DELKKQQEIVAQEKNHAIKKEGELSRTCDRLAE--VEEKLKEKSQQLQEKQQQLLNVQEE 1149
Query: 2039 DTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKE 2098
+ + I+ IE+ + + +EL E+++ +E +EL +L + +++ + + + LKE
Sbjct: 1150 MSEMQKKINEIENLKNELKNKELTLEHME--TERLELAQKLNENYEEVKSITKERKVLKE 1207
Query: 2099 MCEFLKKEKAEVQRKLGHVRGSGRSGKT--------IPELEKTIGLMKKVVEK--VQREN 2148
+ + + E+ ++ + + +G K + E ++TI +++ V + Q N
Sbjct: 1208 LQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIIN 1267
Query: 2149 EQLKKASGILTSEKMANIEQENEKLK--AELEKLKAHLGHQLSMHYESKTKGTEKIIA-E 2205
Q + S E++ + +E E L E+ + + + + +S TK + + E
Sbjct: 1268 TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIE 1327
Query: 2206 NERLR---------KELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGP 2256
ERLR +E+K T + L+ K LE+ ++++ + ET ++Q ++S+
Sbjct: 1328 MERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE 1387
Query: 2257 Q---LEGADSKSWKSIVVTRMYETK---LKELETDIAKKNQSITDLKQLVKEATEREQKV 2310
Q ++ D+++ K + ++ K L +E ++ ++ + + +K + + +
Sbjct: 1388 QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDL 1447
Query: 2311 NKYNEDLEQQIKILKH-----VPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEAN 2365
+ E L+ + LK V + ETE+ LK H KE+ E I+++ N
Sbjct: 1448 QRLQEVLQSESDQLKENIKEIVAKHLETEEELK--------VAHCCLKEQEETINELRVN 1499
Query: 2366 KDQSGAE-STIPDA-----DQLKEKIKDL-------------ETQLKMSDLE--KQHLK- 2403
+ E STI D+L+ KI+++ E Q K+++L+ K+H K
Sbjct: 1500 LSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKA 1559
Query: 2404 -----------------------EEIK---KLKKELENFDPSFFEEIEDLKYNYKEEVKK 2437
EEI+ K K+E++ + E + LK N KE V K
Sbjct: 1560 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAK 1619
Query: 2438 NILLEEKVKKLSEQLGVELT 2457
+EK + + V T
Sbjct: 1620 MKESQEKEYQFLKMTAVNET 1639
Score = 76.6 bits (187), Expect = 3e-13
Identities = 138/637 (21%), Positives = 271/637 (42%), Gaps = 97/637 (15%)
Query: 1869 NKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNK 1928
N+ S E L ++ +K L+ ++EEV L+ + K++L + E K K++ +
Sbjct: 336 NEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEK-- 393
Query: 1929 LKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMT-VDQVLGIRALESEKELE 1987
+ LT+ L T LTLQ++LK V LG ++
Sbjct: 394 -------IENLTRMLVT---------SSSLTLQQELKAKRKRRVTWCLG--------KIN 429
Query: 1988 ELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSIS 2047
++K N + +I P + + L L+E ++ + + + ++S
Sbjct: 430 KMKNSNYADQFNI---------PTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLS 480
Query: 2048 GIESDDHC----QREQELQKENLKLSSENIELKFQLEQANKDLPRLK-NQVRDLKEMCEF 2102
IE + Q E + +L+ +N+ L ++ + K+ LK + DL E
Sbjct: 481 EIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEAL 540
Query: 2103 LKKEKAEVQRKLGHVRGSGRSGKTIPEL--EKTIGLMKKVVEKVQRENEQLKKASGILTS 2160
+K K + + +L H + ++ E+ + + VE ++ + +Q+KK + S
Sbjct: 541 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDS 600
Query: 2161 EKMANIEQENEKLKAELE---KLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKET 2217
+K+ NI+ + +E ++K L ++ ++K + + +EN L++++K+
Sbjct: 601 QKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAF-LRSENLELKEKMKELA 659
Query: 2218 DAAEKL----RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGA-DSKSWKSIVVT 2272
+++ ++ ++ LE +KM V LE K LQ A + +L D K K ++
Sbjct: 660 TTYKQMENDIQLYQSQLEA-KKKMQVDLE---KELQSAFNEITKLTSLIDGKVPKDLLCN 715
Query: 2273 RMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAE 2332
E K+ +L+ K+L KE E NE L +++ +L +
Sbjct: 716 LELEGKITDLQ-------------KELNKEVEE--------NEALREEVILLSELKSLPS 754
Query: 2333 TEQGLKRELQ----VLRLANHQLDKEKAELIH----------QIEANKD-----QSGAES 2373
+ L++E+Q L + + DK +E++H +I KD QS +S
Sbjct: 755 EVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKS 814
Query: 2374 TIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKE 2433
T + K D E + KM E + + +EI L KE + FD S +L Y +E
Sbjct: 815 TDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE 874
Query: 2434 EVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEE 2470
+K ++E++ ++ EQL +L + + + E E+
Sbjct: 875 LQEKTREVQERLNEM-EQLKEQLENRDSTLQTVEREK 910
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 243 bits (621), Expect = 1e-63
Identities = 491/2350 (20%), Positives = 976/2350 (41%), Gaps = 349/2350 (14%)
Query: 55 TQSLMKMKAQE-VELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRF- 112
TQ L M+ Q+ E + ++ +K E +QL +V LE++L++ +D +
Sbjct: 695 TQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQ 754
Query: 113 -LRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAE--NENSKLRRENKRL 169
L E L L+ KD L E ++Q A+ + A E + E
Sbjct: 755 DLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSEC 814
Query: 170 KKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEAN 229
+ + +Q ++ Q ++DS + +L S++ +SD L K+ EL+Q EI+
Sbjct: 815 RLEADQSPKNSAILQNRVDSLEFSLESQKQMNSD----LQKQCEELVQIKGEIE------ 864
Query: 230 EKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKE----NDHYQLQV 285
E + Q + + E+ Q + K+ ++ + + +V +T + ++ +KE ND + +
Sbjct: 865 ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQ 924
Query: 286 QELTDLLKSKNEEDDPIMV------AVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLK 339
E+ +L KS + +D + ++ + +E I+S EI E Q L+E
Sbjct: 925 AEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEI-- 982
Query: 340 NAQLDADKSNVMALQQG----IQERDSQIKMLTEQVEQ----YTKEMEKNTCIIEDLKNE 391
NA L+ +K N++ + I ER+ I L++Q +Q + E+ EDL
Sbjct: 983 NASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLS-- 1040
Query: 392 LQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKR---- 447
Q+ K A + + + + + + E E+ E + +E +L A +R
Sbjct: 1041 -QKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNL 1099
Query: 448 LKDYESGVYGLEDAVVEIKN-CKNQIKIRDREIEILTKEINKLELKISDFLDENEAL--- 503
+ + E+ L + + +N K++ +EI L +E NK++ +++D L ENE L
Sbjct: 1100 MLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKV 1159
Query: 504 ----RERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEI-------ESLEEERLDL 552
E LE + + + + R S+ Q ++ + + +KEI + ++ E +
Sbjct: 1160 MKTKHECQNLESEPIRNSVKERESER-NQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLR 1218
Query: 553 KKKIRQMAQERGKRSATSGLTT-----EDLNLTENISQG-DRISERKLD-----LLSLKN 601
K+++ E+ K L T E NL + SQ + + ++D +
Sbjct: 1219 NKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHE 1278
Query: 602 MSEAQSKNEFLSREL---IEKERDLER--------SRTVIAKFQNKLKELVEENKQLEEG 650
+S +Q+ N L L + K +LE+ ++ + + E + +++ E
Sbjct: 1279 LSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEE 1338
Query: 651 MKEILQAIKEMQKDPDVKGGETSLIIPSLE-----------RLVNAIESKNAEGIFDASL 699
+ ++L +K + D + GE IP E L ES + E + +
Sbjct: 1339 VGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDK 1398
Query: 700 HLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLL----RQSEG 755
++ +L + L+ E + + S ++++ +D L+ E +L R +G
Sbjct: 1399 EVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQG 1458
Query: 756 SNVVFKGIDLPDGIAPS--------SASIINSQNEYLIHLLQELENKEKKLKNLEDSLED 807
V + L +G+ PS S+S+ + + L E L NLE ++
Sbjct: 1459 DLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSA 1518
Query: 808 YNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNA 867
+ +V S L +E L+ KET +K + EE L + +Q K++E
Sbjct: 1519 --NQCSVDEVFCSSLQEENLTRKETPSAPAKGV-EELESLCEVYRQSLEKLEEKMESQGI 1575
Query: 868 LQ-MDSDEMKKILAENSRKITVLQ---VNEKSLIRQYTTLVELERQLRKENEKQKNELLS 923
++ + E++++L+ +++ L+ ++E +Q T V LE + + EK++ E LS
Sbjct: 1576 MKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLS 1635
Query: 924 MEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKY------- 976
+E EV ++ I + + S + + E T K+
Sbjct: 1636 LELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICD 1695
Query: 977 RDILQKDNMLVQRTSNLEHLECENISLKEQVESINKE----------LEITKEKLHTIEQ 1026
+D Q N+ +++ + ++ EQ N E E E +
Sbjct: 1696 KDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPN 1755
Query: 1027 AWEQETKLGNESSMDKAK---KSITNSDIVSI------SKKITML--EMKELNERQRAEH 1075
A LGN+ + + K +N ++ + +K+ L EMKEL+ + +
Sbjct: 1756 ALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQE 1815
Query: 1076 CQKMYE-----HLRTSLKQMEERNFELETKFA-------ELTK-------INLDAQK-VE 1115
Q M + L + ++++ N +L K EL + +N D + +
Sbjct: 1816 VQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHAD 1875
Query: 1116 QMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQS 1175
+ R+++ D+V+K V+D+ ++R L++E ++ E + + + +E++ ++
Sbjct: 1876 KSSREDIGDNVAK-VNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLC 1934
Query: 1176 RDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKL-ESITSKLQKMEAY 1234
+K+ E+ + ++ + + + + + + TAL +L E + K Q++E++
Sbjct: 1935 LEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESH 1994
Query: 1235 NLRL-------EQKLDEKEQALYYARLEGRNRAK---HLRQTIQSLRRQFSGALPLAQQE 1284
E ++ EK + L + K HL++ +QSL + +
Sbjct: 1995 QSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKD---------SQ 2045
Query: 1285 KFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKG--AQ 1342
S T +L+N ++ +E + +E +++ + E + + + + + KG A
Sbjct: 2046 ALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFAL 2105
Query: 1343 KVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEE 1402
++ + ++ +LR KL + D+++ ++ + E ER SL++++
Sbjct: 2106 RLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVE-------- 2157
Query: 1403 RQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKE 1462
+LER+L + + Q ++ A+ + + L Q+E R +K
Sbjct: 2158 ----------NLERELQMSEENQELVILDAENSKAEVET-------LKTQIEEMARSLKV 2200
Query: 1463 NIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAEL 1522
++ R+ ++L ++++EK+ L DK+++ + L EK AE+
Sbjct: 2201 FELDLVTLRSEKENLTKQIQEKQGQLS-------ELDKLLSSFKSLL-----EEKEQAEI 2248
Query: 1523 GRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLH 1582
KE + L+ + + A L +E++K ++ L+ EE+ ++ E+
Sbjct: 2249 QIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEK--- 2305
Query: 1583 ILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLV 1642
L RLE L +Q +K+S +H L
Sbjct: 2306 -LRARLEADEKKQLCVLQQ-----LKES-------EHHADL------------------- 2333
Query: 1643 KLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVE---------DLKYL 1693
LK ++LER+ EI E+ L+ EN + EV+ +KA++E +L +
Sbjct: 2334 -LKGRVENLERELEIARTNQ---EHAALEA-ENSKGEVETLKAKIEGMTQSLRGLELDVV 2388
Query: 1694 LDQSQKESQCLKSELQAQKEANSRAP--TTTMRNLV-ERLKSQLALKEKQQKALSRALLE 1750
+S+KE+ L +ELQ ++E S ++ N++ E+ + ++ +KEK A+ +
Sbjct: 2389 TIRSEKEN--LTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ 2446
Query: 1751 LRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKN 1810
L+ ER+ + + +EA +Q L +QVE L +L + L +KN
Sbjct: 2447 LKE-----LNERVAALHNDQEACKAKEQ-------NLSSQVECLELEKAQLLQGLDEAKN 2494
Query: 1811 RENSLTDNLNDLNNEL----QKKQKAYNKILREKEEI-DQEN---------------DEL 1850
L ++N L E+ QK +K +I R K +I DQE E
Sbjct: 2495 NYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQ 2554
Query: 1851 KRQIKRLTSGLQGK-----PLTDNKQSLIEELQRKVKKLENQLE-------GKVEEVDLK 1898
+++ LT L+ K + Q +E LQ K LEN+LE VE+V+
Sbjct: 2555 NLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKM 2614
Query: 1899 PMKEKNAKEELIRW-EEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEK 1957
KE + E+ ++ + Q ++ G +N+L GE+ L +++ + KD + E
Sbjct: 2615 TAKETELQREMHEMAQKTAELQEELSGEKNRLA---GELQLLLEEIKSSKDQLKELTLEN 2671
Query: 1958 LTLQRKLKTTGMTVDQVLGIRALESE-KELEELKKRNLDLENDILYMRAHQALPRDSVVE 2016
L++ L M DQV E E K EE+ + L L + HQAL D+ +
Sbjct: 2672 SELKKSLDC--MHKDQV------EKEGKVREEIAEYQLRLHEA---EKKHQALLLDTN-K 2719
Query: 2017 DLHLQNRYLQEKLHALEKQFSKDTYSKPSI--SGIESDDHCQREQELQKENLKLSSENI- 2073
++ + +EKL + E+ S + S E ++ + ++ +E K +N+
Sbjct: 2720 QYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLK 2779
Query: 2074 ---ELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPEL 2130
+LK + E+A + L + L+E E L+KE +++Q + + EL
Sbjct: 2780 YVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDEL 2839
Query: 2131 EKTIGLMKKVV-EKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLS 2189
I +K+ + EK + +E L K +L S +EKL+ E L+ + H S
Sbjct: 2840 TTEIKELKETLEEKTKEADEYLDKYCSLLIS---------HEKLEKAKEMLETQVAHLCS 2890
Query: 2190 MHYESKTKGT 2199
+ ++G+
Sbjct: 2891 QQSKQDSRGS 2900
Score = 237 bits (605), Expect = 9e-62
Identities = 517/2588 (19%), Positives = 1049/2588 (40%), Gaps = 380/2588 (14%)
Query: 33 SKVEVNELKSE----KQENVIHLFRITQSLMKMKAQEV---ELALEEVEKAGEEQAKFEN 85
S+++ NEL+ K+EN + +S + KA+EV E L+ +++ + F
Sbjct: 470 SQIKENELRRSMEEMKKEN-----NLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAE 524
Query: 86 QLKTKVMKLENELEMAQQSAGGRDTRF----LRNEICQLEKQ-------LEQKDRELEDM 134
++K K E L Q+ ++ L+ + LEKQ L++++ +E +
Sbjct: 525 EMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQL 584
Query: 135 EKELEKEKKVNEQLALRNEEAENENSKLRRENKRL---KKKNEQLCQDIIDYQKQIDSQK 191
+L K +K ++ L E + E +L+ E K +NE+L Q++S+K
Sbjct: 585 NDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLT-------QMESEK 637
Query: 192 ETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEME 251
E L S+ K++E Y + ++TL E + V+ + + L+ E+E
Sbjct: 638 ENLQSKINHLETCLKTQQIKSHE---YNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVE 694
Query: 252 KMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELT----------DLLKSKNEEDDP 301
Y ++ +D + +KE ++ L+ +LT LL ++ + D
Sbjct: 695 TQKLAYMELQQKAEFSDQ---KHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDR 751
Query: 302 IMVAVNAKVEEWKLILSSKDDEII------------EYQQMLHN-----------LREKL 338
++A+ E + +L SKD ++ + Q +H+ + +
Sbjct: 752 CYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSER 811
Query: 339 KNAQLDADKS--NVMALQQGI----------QERDSQIKMLTEQVEQYTKEMEKNTCIIE 386
+L+AD+S N LQ + ++ +S ++ E++ Q E+E+N E
Sbjct: 812 SECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAE 871
Query: 387 DLKNEL--QRNKGASTLSQQTHMK---IQSTLDILKEKTKEAERTAELAEADAREKDKEL 441
+ + ++ S L + T + TL L+ K KE + + E + E +EL
Sbjct: 872 QMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEI-QEL 930
Query: 442 VEALKRLKDYESGVYGLEDAV-VEIKNCKNQIKIRDREIEILT------KEIN-KLELKI 493
++ L+D + L + + +E K + I + REIE LT KEIN L +
Sbjct: 931 KKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEK 990
Query: 494 SDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLK 553
+ + ++E+ + K++ +L++ QY+ E ILL+ E DL
Sbjct: 991 MNLIQKSESFANYIDEREKSISELSD----------QYKQEKLILLQRCEETGNAYEDLS 1040
Query: 554 KKIRQMAQERGKRSATSGLTTEDLNLTENISQG-----DRISERKLDLLSLKNMSEAQSK 608
+K + AQE K S L E +L EN + ++ + L+ +E +++
Sbjct: 1041 QKYKA-AQE--KNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQ 1097
Query: 609 NEFLSRELIEKERDLE------RSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQ 662
N L E +++ E S++ + ++ L EE ++++ + ++LQ +++
Sbjct: 1098 NLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLM 1157
Query: 663 KDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLK----------AQVDQLTG-- 710
K K +L + V ES+ + F + L+ AQ+ QL
Sbjct: 1158 KVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAML 1217
Query: 711 RNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIA 770
RN+EL+ + E KE + + Q + +L+ +L+ ++ E S + ID +
Sbjct: 1218 RNKELKLQESEKEKECLQHELQTIRGDLETSNLQD----MQSQEISGLKDCEIDAEEKYI 1273
Query: 771 PSSASIINSQNE--YLIHLLQELENKEKKLKNLEDSLEDYNRKFAVI------RHQQSLL 822
+ SQN+ +L LQ NK +L+ + + L+ K+ ++ R +
Sbjct: 1274 SGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQA--EKYELVTELNDSRSECITA 1331
Query: 823 YKEYLSEKETWKTESKTIKEEKRKLEDQVQQD----------------AIKVKEYNNLLN 866
++ E E K + ++ L ++ +D ++ + +N
Sbjct: 1332 TRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYE 1391
Query: 867 ALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEA 926
L + E++ AE K LQ K L Q+ + +L+ + K E L +
Sbjct: 1392 HLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLST 1451
Query: 927 EVCEKIGCLQRFKEMAIFK--IAALQK-VVDNSVSLSELELANKQYNELTAKYRDILQKD 983
+ G L + ++ + + + +L V +S SLS L + Y L + D+
Sbjct: 1452 NLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLG-DSSFYRALLEQTGDMSLLS 1510
Query: 984 NMLVQRTSN--------LEHLECENISLKEQ-------VESINKELEITKEKLHTIEQAW 1028
N+ ++N L+ EN++ KE VE + E+ ++ L +E+
Sbjct: 1511 NLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKM 1570
Query: 1029 EQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLK 1088
E + + N+ + + + + +K + E ++ ++ + + M L K
Sbjct: 1571 ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLE-MESKLAAEKK 1629
Query: 1089 QMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMEL 1148
Q E+ + ELE +L ++L ++ +L + D++ D + E E
Sbjct: 1630 QTEQLSLELEVARLQLQGLDLSSRS---LLGIDTEDAIQGRNESCDISKEHTSETTERTP 1686
Query: 1149 KVEVSKLREISDIARRQVEILNAQQQSRDK---EVESLRMQLLDYQAQSDEKSLIAKLHQ 1205
K +V ++ + ++I + K E + +Y+ ++K+ + +
Sbjct: 1687 KHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSS--E 1744
Query: 1206 HNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQ 1265
L S AL ++ + ++ + +NL+L K E +E R+R +
Sbjct: 1745 CISELSFSGPNALVPMDFLGNQ---EDIHNLQLRVKETSNENLRLLHVIEDRDRKV---E 1798
Query: 1266 TIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKL 1325
++ + ++ L L QE T I+ + KI+ E+K EN L +L+
Sbjct: 1799 SLLNEMKELDSKLHL--QEVQLMTKIEACIELEKIVGELKK--------ENSDLSEKLEY 1848
Query: 1326 KGLE--ELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKD--KEEIKYLNNIISE 1381
+ EL+ ++ ++G + H ++ +++ N V D KE + N +S
Sbjct: 1849 FSCDHQELLQRVETSEGLNSDLEMHA--DKSSREDIGDNVAKVNDSWKERFLDVENELSR 1906
Query: 1382 YERTISSLEEE---------IVQQNKFHEERQMAWDQRE-VDLERQLDIFDRQQNEILNA 1431
+S+E E +VQ K E+ Q+ V LE +L + ++N++
Sbjct: 1907 IRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGE 1966
Query: 1432 AQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATC----KSLEEKLKEKESA 1487
+ T ++ S K+KE + + ++ C + E ++KEK
Sbjct: 1967 LDTMSKKTTALDQLS-----------EKMKEKTQELESHQSECLHCIQVAEAEVKEKTEL 2015
Query: 1488 LRLAEQNI--LSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANM 1545
L+ ++ L +DK + +L+ + E++ L + E+E N
Sbjct: 2016 LQTLSSDVSELLKDKTHLQEKLQ---SLEKDSQALSLTKCELE---------------NQ 2057
Query: 1546 QARLNQKEEVLKKYQRLLEKAREE---QREIVKKHEEDLHILHHRLELQADSSLNKFKQT 1602
A+LN+++E+L K L+ E ++ V K E + L+ S+ + Q
Sbjct: 2058 IAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQL 2117
Query: 1603 AWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKV 1662
+ K K + +AE + ++DSL K++ + ++L+ E EL +
Sbjct: 2118 RRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKD---KVENLERELQMSEENQELVI 2174
Query: 1663 KEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTT 1722
+ EN K AEVE LK +++ + + + +L T
Sbjct: 2175 LDAENSK---------------AEVETLKTQIEEMARSLKVFELDL------------VT 2207
Query: 1723 MRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDR 1782
+R+ E L Q+ K+ Q L + L ++ + EE+ + KE +++
Sbjct: 2208 LRSEKENLTKQIQEKQGQLSELDKLLSSFKSLL----EEKEQAEIQIKEESKTAVEMLQN 2263
Query: 1783 HTRELKTQVEDL--NENLLKLKE-ALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILRE 1839
+EL V L ++ ++K E +L E+ L +++ L L+ +K +L++
Sbjct: 2264 QLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQ 2323
Query: 1840 KEEIDQENDELKRQIKRLTSGLQ--------GKPLTDNKQSLIEELQRKVKKLENQLEG- 1890
+E + D LK +++ L L+ +N + +E L+ K++ + L G
Sbjct: 2324 LKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGL 2383
Query: 1891 KVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLF 1950
+++ V ++ KE E E + + N L+EKE E + ++ +T ++
Sbjct: 2384 ELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEM- 2442
Query: 1951 AKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALP 2010
LQ +LK V AL +++E + K++NL + + L + Q L
Sbjct: 2443 ---------LQTQLKELNERV------AALHNDQEACKAKEQNLSSQVECLELEKAQLLQ 2487
Query: 2011 RDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSS 2070
++ ++ LQ ++ L ++ K + + + + Q +E L
Sbjct: 2488 GLDEAKNNYI---VLQSSVNGLIQEVED---GKQKLEKKDEEISRLKNQIQDQEQLVSKL 2541
Query: 2071 ENIELKFQL-EQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPE 2129
+E + QL ++ N +L +N +L++ + L+ + A +Q L ++ S ++ + E
Sbjct: 2542 SQVEGEHQLWKEQNLEL---RNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELE 2598
Query: 2130 LEKT--IGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQ 2187
L K + ++KV + +E E +M + Q+ +L+ EL K L +
Sbjct: 2599 LTKMDKMSFVEKVNKMTAKETE---------LQREMHEMAQKTAELQEELSGEKNRLAGE 2649
Query: 2188 LSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKR 2247
L + E + K ++ + E ELKK D K ++ K K+ ++ E R
Sbjct: 2650 LQLLLE-EIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEG------KVREEIAEYQLR 2702
Query: 2248 LQFAESRGPQLEGADSKSWKSIVVTRMYETKLKE-------LETDIAKKN---------- 2290
L AE + L +K ++ + T + KE LE D+ K +
Sbjct: 2703 LHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKA 2762
Query: 2291 --QSITDLKQLVKEATEREQKVNKYNEDLEQQIKIL-KHVPEGAETEQGLKRELQVLRLA 2347
Q + +LK+ + + ++ K NE + ++K+L K + E ++ L++EL L+ A
Sbjct: 2763 TTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAA 2822
Query: 2348 NHQ------LDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQH 2401
+ +D + EL +I+ K+ E +AD+ +K L + + K+
Sbjct: 2823 QEKQKTGTVMDTKVDELTTEIKELKET--LEEKTKEADEYLDKYCSLLISHEKLEKAKEM 2880
Query: 2402 LKEEIKKL 2409
L+ ++ L
Sbjct: 2881 LETQVAHL 2888
Score = 235 bits (599), Expect = 5e-61
Identities = 542/2684 (20%), Positives = 1102/2684 (41%), Gaps = 415/2684 (15%)
Query: 37 VNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLEN 96
+++LK++ QE ++ K E+EL L+ EK + Q +L+ ++ K +
Sbjct: 280 LDQLKAQNQE------------LRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKV 327
Query: 97 ELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAE 156
EL ++ R+E+ + Q +Q + +E++L KK+ E L+ + + AE
Sbjct: 328 ELIEKEKVLNK-----CRDELVRTTAQYDQASTKYTALEQKL---KKLTEDLSCQRQNAE 379
Query: 157 NENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELI 216
+ L ++ K +K ++Q+++ Q+ + + E +++L++ EL
Sbjct: 380 SARCSLEQKIKEKEK----------EFQEELSRQQRSFQTLDQECIQMKARLTQ---ELQ 426
Query: 217 QYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKK 276
Q + L +K+ Q++ NLEE Q++ + + + ++ ++++KK
Sbjct: 427 QAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKK 486
Query: 277 END----HYQLQVQELTDL------LKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIE 326
EN+ H + + +E+ L +K + + AK + +L ++I +
Sbjct: 487 ENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQ 546
Query: 327 YQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIE 386
+ L EKLK A D +K + Q +++R+ I+ L +++ + KE + +E
Sbjct: 547 QENSL--TLEKLKLAVADLEKQRDCS-QDLLKKREHHIEQLNDKLSKTEKESKALLSALE 603
Query: 387 DLKNELQRNKGASTLS---QQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVE 443
K E + K TL + + K+ + ++ KE + E + K E E
Sbjct: 604 LKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNE 663
Query: 444 ALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILT------------------KE 485
++ L+ E+ VEI+N N + + E+E KE
Sbjct: 664 RVRTLE------MDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKE 717
Query: 486 INKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESL 545
I + LK S + E L ++ L ++D H + + R LLK ++
Sbjct: 718 IENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRD----LLKSKDAS 773
Query: 546 EEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQ----------GDRISERKLD 595
D ++ + Q+ + + + E ++ S+ I + ++D
Sbjct: 774 LVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVD 833
Query: 596 LL--SLKNMSEAQSKNEFLSRELIEKERDLERS--------RTVIAKFQNKLKELVEENK 645
L SL++ + S + EL++ + ++E + ++ +A+ ++ +L E+
Sbjct: 834 SLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTS 893
Query: 646 QLEEGMKEILQAIKEMQKDPDVKGGETS--------------LIIPSLERL-----VNAI 686
+ + E L A++ +K+ + + L+ SL+ L ++
Sbjct: 894 AHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSL 953
Query: 687 ESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKE 746
E K I + K ++++LT N L++ +E +N Q+ ID EK
Sbjct: 954 EKKEMSSIISLN---KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKS 1010
Query: 747 TS------------LLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQEL-EN 793
S LL++ E + ++ + A NS+ E L++ L EN
Sbjct: 1011 ISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEK----NSKLECLLNECTSLCEN 1066
Query: 794 KEKKLKNLEDSLEDYNRKF------AVIRHQQSLLYKEYL----------------SEKE 831
++ +L+ L+++ +++F A R+Q +L E + SE
Sbjct: 1067 RKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAG 1126
Query: 832 TWKTESKTIKEEKRKLEDQV----QQDAIKVKEYNNLLNALQMDSDEMKKILAE------ 881
K E T+KEE+ K++ +V Q++ +K ++S+ ++ + E
Sbjct: 1127 GLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERN 1186
Query: 882 --NSRKITVLQVNEKSLIRQYTTLVELERQLR------KENEKQKNELLSMEAEVCEKIG 933
N + L+V E SL LV+LE LR +E+EK+K E L E +
Sbjct: 1187 QCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEK-ECLQHELQTIRGDL 1245
Query: 934 CLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNL 993
++M +I+ L+ D + E ++ +EL+ D L + L
Sbjct: 1246 ETSNLQDMQSQEISGLK---DCEIDAEEKYISGP--HELSTSQNDNAHLQCSLQTTMNKL 1300
Query: 994 EHLE--CENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSD 1051
LE CE I E+ E + + + E + + E+ KL NE + + + +
Sbjct: 1301 NELEKICE-ILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGE 1359
Query: 1052 IVSISKKITMLEMKELNERQRAEHCQKM--------YEHLRTSLKQMEERNFELETKFAE 1103
+V + E E+ +H + YEHL S K+++ EL+ KF
Sbjct: 1360 LVED------IPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLS 1413
Query: 1104 LTKINLDAQKVEQMLRDELADSVSKAVS-----DADRQRILELEKN----------EMEL 1148
L Q ++L D+ SK D+ + L L N EM+L
Sbjct: 1414 L-------QSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQL 1466
Query: 1149 KVEVSKLREISDIARRQVEILNAQ----------QQSRDKEVESLRMQLLDYQAQSDEKS 1198
+E + +S L++ +Q+ D + S + S ++
Sbjct: 1467 GLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEV 1526
Query: 1199 LIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRN 1258
+ L + N++ + + + +E + S E Y LE KL+EK ++ + +
Sbjct: 1527 FCSSLQEENLTRKETPSAPAKGVEELESLC---EVYRQSLE-KLEEKMESQGIMKNKEIQ 1582
Query: 1259 RAKHL----RQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNM 1314
+ L RQ + LR+Q+ QQ K + +++++ K+ E K ++Q +
Sbjct: 1583 ELEQLLSSERQELDCLRKQYLSENEQWQQ-KLTSVTLEMES---KLAAEKKQTEQLSLEL 1638
Query: 1315 ENKTLEMELKLKGLEELISTLK--DTKGAQKVINWHMKIEELRLQEL-----KLNRELVK 1367
E L+L+GL+ +L DT+ A + N I + E K + +
Sbjct: 1639 E----VARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQIC 1694
Query: 1368 DKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNE 1427
DK+ + LN I E+I + + + +Q D + D+ Q
Sbjct: 1695 DKDAQQDLNLDI-----------EKITETGAVKPTGECSGEQSP-DTNYEPPGEDKTQG- 1741
Query: 1428 ILNAAQKFEEATGSIPDPSLP---LPNQLEIALRKIK------ENIRI--ILETR-ATCK 1475
+++ E + S P+ +P L NQ +I +++ EN+R+ ++E R +
Sbjct: 1742 ---SSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVE 1798
Query: 1476 SLEEKLKEKESALRLAEQNILSR-------DKVINELRLRLPATAER-EKLIAELGRKEM 1527
SL ++KE +S L L E ++++ +K++ EL+ +E+ E +
Sbjct: 1799 SLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQ 1858
Query: 1528 EPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHR 1587
++ L + A+ +R + + V K E+ + + E+ + E I H
Sbjct: 1859 RVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEA 1918
Query: 1588 LELQADSSL-----------NKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDS 1636
L L+AD + N+ KQ +++ + V + ++ +R E++ T++++ +
Sbjct: 1919 LYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLR-GELD-TMSKKTTA 1976
Query: 1637 LSSLLVKLKKVSQDLERQR-------EITELKVKEFENIKLQLQENHEDEVKKVKAEVED 1689
L L K+K+ +Q+LE + ++ E +VKE K +L + +V ++ +
Sbjct: 1977 LDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKE----KTELLQTLSSDVSELLKDKTH 2032
Query: 1690 LKYLLDQSQKESQCL---KSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSR 1746
L+ L +K+SQ L K EL+ Q ++ ++ E L+++L+ + ++ +S+
Sbjct: 2033 LQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKES-ESLQARLSESDYEKLNVSK 2091
Query: 1747 ALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALK 1806
AL A + E + +++Q+E H + R +L+ ++E + L + E LK
Sbjct: 2092 AL---EAALVEKGEFALRLSSTQEEVHQ-----LRRGIEKLRVRIEADEKKQLHIAEKLK 2143
Query: 1807 TSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQG--- 1863
+ +SL D + +L ELQ ++ ++ + E E + LK QI+ + L+
Sbjct: 2144 ERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFEL 2203
Query: 1864 --KPLTDNKQSLIEELQRKVKKLENQLEGKVEEVD-----LKPMKEKNAKEELIRWEEGK 1916
L K++L +++Q K +G++ E+D K + E+ + E+ EE K
Sbjct: 2204 DLVTLRSEKENLTKQIQEK--------QGQLSELDKLLSSFKSLLEEKEQAEIQIKEESK 2255
Query: 1917 KWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKAD---KEKLTLQRKLKTTGMTVD- 1972
+E ++N+LKE V L +K D +E+ L+ ++ ++
Sbjct: 2256 ---TAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA 2312
Query: 1973 ----QVLGIRAL-ESEKELEELKKRNLDLENDILYMRA---HQALPRDSV---VEDLHLQ 2021
Q+ ++ L ESE + LK R +LE ++ R H AL ++ VE L +
Sbjct: 2313 DEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAK 2372
Query: 2022 NRYLQEKLHALEKQFSKDTYSKPS-----------ISGIE----SDDHCQREQELQKENL 2066
+ + L LE K + IS +E S ++ +E+E +K +
Sbjct: 2373 IEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQM 2432
Query: 2067 KLSSENIE--LKFQLEQANKDLPRLKN-------QVRDLKEMCEFLKKEKAEVQRKLGHV 2117
K S L+ QL++ N+ + L N + ++L E L+ EKA++ + L
Sbjct: 2433 KEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEA 2492
Query: 2118 RGS-----GRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEK 2172
+ + I E+E ++K E++ R Q++ +++ K++ +E E++
Sbjct: 2493 KNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS--KLSQVEGEHQL 2550
Query: 2173 LKA---ELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNN 2229
K EL L L ++ + +SK + + E L+ K + E ++ K +
Sbjct: 2551 WKEQNLELRNLTVELEQKIQV-LQSKNASLQDTL---EVLQSSYKNLENELELTKMDKMS 2606
Query: 2230 LEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKK 2289
KMT + E + + + +L+ S + EL+ + +
Sbjct: 2607 FVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLA---------GELQLLLEEI 2657
Query: 2290 NQSITDLKQLVKEATEREQKVNKYNED-LEQQIKILKHVPEGAETEQGLKRELQVLRLAN 2348
S LK+L E +E ++ ++ ++D +E++ K+ + + E +++ Q L L
Sbjct: 2658 KSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDT 2717
Query: 2349 HQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
++ + + + + +K++ + + + D LK ++L LK + + EE+KK
Sbjct: 2718 NKQYEVEIQTYREKLTSKEECLSSQKL-EIDLLKSSKEELNNSLKATT----QILEELKK 2772
Query: 2409 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452
K + + +E E + K +K LEE+ + L ++L
Sbjct: 2773 TKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKEL 2816
Score = 234 bits (596), Expect = 1e-60
Identities = 552/2625 (21%), Positives = 1073/2625 (40%), Gaps = 427/2625 (16%)
Query: 16 DDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSL----MKMKA---QEVEL 68
+DL Q + A++ SL + ++ E + E QE + R Q+L ++MKA QE++
Sbjct: 369 EDLSCQRQNAESARCSLEQ-KIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQ 427
Query: 69 ALE-------EVEKAGEEQAKFENQL---KTKVMKLENELEMAQ--QSAGGRDTRFLRNE 116
A E++K + + EN L K K+ + E + +Q ++ R ++ E
Sbjct: 428 AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487
Query: 117 ICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKK---- 172
L+ EQK RE+ +E EL+ K+ Q EE + +N+ + L++K
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQ 547
Query: 173 -----NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYE---LIQYLD---- 220
E+L + D +KQ D ++ L R +LSK E L+ L+
Sbjct: 548 ENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKK 607
Query: 221 EIQTLTE----------ANEKIEVQNQEMRKNLEESVQEMEK-------MTDEYN----- 258
E + L E NEK+ Q + ++NL+ + +E + EYN
Sbjct: 608 EYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRT 667
Query: 259 ------RMKAIVHQTDNVID-------------------------QLKKENDHYQLQVQE 287
+ + NV+D + +KE ++ L+ +
Sbjct: 668 LEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQ 727
Query: 288 LT----------DLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEII------------ 325
LT LL ++ + D ++A+ E + +L SKD ++
Sbjct: 728 LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAF 787
Query: 326 EYQQMLH-----------NLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQY 374
+ Q +H ++ + +L+AD+S + +Q R ++ E +Q
Sbjct: 788 DQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI--LQNRVDSLEFSLESQKQM 845
Query: 375 TKEMEKNTCIIEDLKNELQRN-KGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEAD 433
+++K + +K E++ N A + Q + + L+E T + +
Sbjct: 846 NSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSA 905
Query: 434 AREKDKEL------VEALK-RLKDYESGVYGLEDAVVEI-----------KNCKNQIKIR 475
K+KEL VE + +++ + + LED++ E+ K + I +
Sbjct: 906 LENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN 965
Query: 476 DREIEILT------KEIN-KLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQ 528
REIE LT KEIN L + + + ++E+ + K++ +L++
Sbjct: 966 KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSD--------- 1016
Query: 529 QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQ--- 585
QY+ E ILL+ E DL +K + AQE K S L E +L EN
Sbjct: 1017 -QYKQEKLILLQRCEETGNAYEDLSQKYK-AAQE--KNSKLECLLNECTSLCENRKNELE 1072
Query: 586 --GDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLE------RSRTVIAKFQNKL 637
+ ++ + L+ +E +++N L E +++ E S++ + ++
Sbjct: 1073 QLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEI 1132
Query: 638 KELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDA 697
L EE ++++ + ++LQ +++ K K +L + V ES+ + F
Sbjct: 1133 MTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKP 1192
Query: 698 SLHLK----------AQVDQLTG--RNEELRQELRESRKEAINYSQQLAKANLKIDHLEK 745
+ L+ AQ+ QL RN+EL+ + E KE + + Q + +L+ +L+
Sbjct: 1193 QMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQD 1252
Query: 746 ETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSL 805
++ E S + ID + + SQN+ HL L+ KL LE
Sbjct: 1253 ----MQSQEISGLKDCEIDAEEKYISGPHELSTSQNDN-AHLQCSLQTTMNKLNELEKIC 1307
Query: 806 EDYN-RKFAVI------RHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQD---- 854
E K+ ++ R + ++ E E K + ++ L ++ +D
Sbjct: 1308 EILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGG 1367
Query: 855 ------------AIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTT 902
++ + +N L + E++ AE K LQ K L Q+
Sbjct: 1368 EFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQ 1427
Query: 903 LVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFK--IAAL-QKVVDNSVSL 959
+ +L+ + K E L + + G L + ++ + + + +L V +S SL
Sbjct: 1428 MSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSL 1487
Query: 960 SELELANKQYNELTAKYRDILQKDNMLVQRTSN--------LEHLECENISLKEQ----- 1006
S L + Y L + D+ N+ ++N L+ EN++ KE
Sbjct: 1488 SSLG-DSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPA 1546
Query: 1007 --VESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEM 1064
VE + E+ ++ L +E+ E + + N+ + + + + +K + E
Sbjct: 1547 KGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSEN 1606
Query: 1065 KELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELAD 1124
++ ++ + + M L KQ E+ + ELE +L ++L ++ +L + D
Sbjct: 1607 EQWQQKLTSVTLE-MESKLAAEKKQTEQLSLELEVARLQLQGLDLSSR---SLLGIDTED 1662
Query: 1125 SVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDK---EVE 1181
++ D + E E K +V ++ + ++I + K E
Sbjct: 1663 AIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECS 1722
Query: 1182 SLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQK 1241
+ +Y+ ++K+ + + L S AL ++ + + + + +NL+L K
Sbjct: 1723 GEQSPDTNYEPPGEDKTQGSS--ECISELSFSGPNALVPMDFLGN---QEDIHNLQLRVK 1777
Query: 1242 LDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIM 1301
E +E R+R +++ + ++ L L QE T I+ + KI+
Sbjct: 1778 ETSNENLRLLHVIEDRDRKV---ESLLNEMKELDSKLHL--QEVQLMTKIEACIELEKIV 1832
Query: 1302 QEMKNSQQEHRNMENKTLEMELKLKGL--EELISTLKDTKGAQKVINWHMKIEELRLQEL 1359
E+K EN L +L+ +EL+ ++ ++G + H ++ +++
Sbjct: 1833 GELKK--------ENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMH--ADKSSREDI 1882
Query: 1360 KLNRELVKD--KEEIKYLNNIISEYERTISSLEE---------EIVQQNKFHEERQMAWD 1408
N V D KE + N +S +S+E E+VQ K E+
Sbjct: 1883 GDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENK 1942
Query: 1409 QRE-VDLERQLDIFDRQQNEIL--------------NAAQKFEEATGSIPDPSLPLPNQL 1453
Q+ V LE +L + ++N++ ++K +E T + + +
Sbjct: 1943 QKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCI 2002
Query: 1454 EIALRKIKENIRIILETRATCKS--------LEEKLK--EKES-ALRLAEQNILSRDKVI 1502
++A ++KE +L+T ++ S L+EKL+ EK+S AL L + + ++ +
Sbjct: 2003 QVAEAEVKEKTE-LLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQL 2061
Query: 1503 NELRLRLPATAEREKLIAELGRKEMEPKS-HHTLKIAHQTIANMQARLNQKEEVLKKYQR 1561
N+ + L E E L A L + E + L+ A RL+ +E + + +R
Sbjct: 2062 NKEKELL--VKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRR 2119
Query: 1562 LLEKAR-----EEQREI-----VKKHEEDLHILHHRLE-LQADSSLNKFKQTAWDL-MKQ 1609
+EK R +E++++ +K+ E + L ++E L+ + +++ Q L +
Sbjct: 2120 GIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAEN 2179
Query: 1610 SPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDL-ERQREITELKVKEFENI 1668
S V T K ++ EM +++ + L +L + + +++ + E+Q +++EL K +
Sbjct: 2180 SKAEVETLK--TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELD-KLLSSF 2236
Query: 1669 KLQLQENHEDEVKKVKAEVEDLKYLLDQSQKE------SQCLKSELQAQKEANSRAPTT- 1721
K L+E + E+ ++K E + +L KE + C E+ E + P
Sbjct: 2237 KSLLEEKEQAEI-QIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEE 2295
Query: 1722 --TMRNLVERLKSQLALKEKQQKALSRALLE-------LRAEMTAAAEERIISATSQKEA 1772
+RN +E+L+++L EK+Q + + L E L+ + E I+ T+Q+ A
Sbjct: 2296 EHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHA 2355
Query: 1773 HLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKA 1832
L + LK ++E + ++L L+ + T ++ + +LT NELQK+Q+
Sbjct: 2356 ALEAEN-SKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLT-------NELQKEQER 2407
Query: 1833 YNK---ILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLE 1889
++ I E I QE ++ K Q+K +S + Q+ ++EL +V L N E
Sbjct: 2408 ISELEIINSSFENILQEKEQEKVQMKEKSS-----TAMEMLQTQLKELNERVAALHNDQE 2462
Query: 1890 G-KVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKD 1948
K +E +L +++ E + E+ + Q ++ +N + V L +++ K
Sbjct: 2463 ACKAKEQNL------SSQVECLELEKAQLLQG-LDEAKNNYIVLQSSVNGLIQEVEDGKQ 2515
Query: 1949 LFAKADKEKLTLQRKLKTTGMTV---DQVLGIRALESEKELEELKKRNLDLENDILYMRA 2005
K D+E L+ +++ V QV G L E+ L EL+ ++LE I +++
Sbjct: 2516 KLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNL-ELRNLTVELEQKIQVLQS 2574
Query: 2006 HQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKEN 2065
A +D++ LQ LE + K S + + +E ELQ+E
Sbjct: 2575 KNASLQDTL--------EVLQSSYKNLENELELTKMDKMSFVE-KVNKMTAKETELQREM 2625
Query: 2066 LKLSSENIELKFQLE-QANK---DLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSG 2121
+++ + EL+ +L + N+ +L L +++ K+ + L E +E+++ L +
Sbjct: 2626 HEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKD- 2684
Query: 2122 RSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGIL---TSEKMANIEQENEKLKAELE 2178
++EK + +++ E R +E KK +L + I+ EKL ++ E
Sbjct: 2685 -------QVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEE 2737
Query: 2179 -----KLKAHLGHQLSMHYESKTKGTEKIIAE-------NERLRKELKKETDAAEKLRIA 2226
KL+ L + K T +I+ E N + +LKKE + A+
Sbjct: 2738 CLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQ----G 2793
Query: 2227 KNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDI 2286
K L I K QLEE + LQ S QL+ A K V+ +TK+ EL T+I
Sbjct: 2794 KMKLLI---KSCKQLEEEKEILQKELS---QLQAAQEKQKTGTVM----DTKVDELTTEI 2843
Query: 2287 AKKNQSITDLKQLVKEATE----------REQKVNKYNEDLEQQI 2321
+ ++ L++ KEA E +K+ K E LE Q+
Sbjct: 2844 KELKET---LEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQV 2885
Score = 212 bits (540), Expect = 3e-54
Identities = 502/2598 (19%), Positives = 1052/2598 (40%), Gaps = 350/2598 (13%)
Query: 36 EVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFE--NQLKTKVMK 93
++++LK EKQ+ L + +L K K + E E Q E L+ K
Sbjct: 26 QLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQK 85
Query: 94 LENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALR-- 151
+ +EL++ + F ++ +KQ+E+ ++EL+ + ELE+ ++ + +
Sbjct: 86 ISHELQVKESQVN-----FQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLN 140
Query: 152 --NEEAENENSKLRRENKRLKKKNEQLCQDI---IDYQKQIDSQKETLLSRRGEDSDYRS 206
N + + L K E L + ++ +K+++++ + L +++ + ++
Sbjct: 141 PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQA 200
Query: 207 QLSKKNYELIQYLDEI----QTLTEANEKIEVQNQEMRKNLEESV----QEM--EKMTDE 256
++ ++ Q + Q T ++ Q +R++ S QE+ + T +
Sbjct: 201 TMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQ 260
Query: 257 YNRMKAIVHQTDN-----VIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVE 311
+ A DN ++DQLK +N + ++ EL L+ +E M K +
Sbjct: 261 IGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKE----MKGQVNKFQ 316
Query: 312 EWKLILSSKDDEIIEYQQMLHNLREKL--KNAQLDADKSNVMALQQGIQERDSQIKMLTE 369
E +L L E+IE +++L+ R++L AQ D + AL+Q ++K LTE
Sbjct: 317 ELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQ-------KLKKLTE 369
Query: 370 QVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAEL 429
+ + E C +E +KEK KE +
Sbjct: 370 DLSCQRQNAESARCSLEQK---------------------------IKEKEKEFQEELSR 402
Query: 430 AEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKL 489
+ + D+E ++ RL E++ KN + E++ LT +L
Sbjct: 403 QQRSFQTLDQECIQMKARLTQ-------------ELQQAKNMHNVLQAELDKLTSVKQQL 449
Query: 490 ELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEER 549
E + +F + + R + + I E R S ++ + EN +L E E
Sbjct: 450 ENNLEEF--KQKLCRAEQAFQ-ASQIKENELRRS----MEEMKKENNLLKSHSEQKAREV 502
Query: 550 LDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKL-DLLSLKNMSEAQSK 608
L+ +++ + Q + N E + + E L DL N E
Sbjct: 503 CHLEAELKNIKQ----------CLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLT 552
Query: 609 NEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVK 668
E L + + E+ + S+ ++ K ++ +++L ++ + E+ K +L A++ +K+ +
Sbjct: 553 LEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEEL 612
Query: 669 GGETSLII---PSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKE 725
E +L E+L+ +ES+ E + HL+ + ++ E + +R +
Sbjct: 613 KEEKTLFSCWKSENEKLLTQMESEK-ENLQSKINHLETCLKTQQIKSHEYNERVRTLEMD 671
Query: 726 AINYSQQLAKANLKID--HLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEY 783
N S ++ + +D +E ET L E A + +++
Sbjct: 672 RENLSVEIRNLHNVLDSKSVEVETQKLAYME---------------LQQKAEFSDQKHQ- 715
Query: 784 LIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQ-------QSLLYKEYLSEKETWKTE 836
+E+EN K L +ED K ++ ++ L+ EY S ++ K++
Sbjct: 716 -----KEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSK 770
Query: 837 SKTI---KEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMK-KILAENSRKITVLQVN 892
++ ++ +R L QQ A+ N + M S+ + ++ A+ S K + + N
Sbjct: 771 DASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQN 830
Query: 893 EKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFK------- 945
+ +E ++Q+ + +KQ EL+ ++ E+ E + ++ + + +
Sbjct: 831 R---VDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISK 887
Query: 946 ----IAALQKVVDNSVSL-----SELELANKQYNELTAKYRDILQ---------KDNMLV 987
+A Q VV ++S EL+L N + A+ +++ + K+ L+
Sbjct: 888 LQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLL 947
Query: 988 QRTSNLEHLECEN-ISL-KEQVESINKE--------LEITKEKLHTIEQAW-------EQ 1030
T +LE E + ISL K ++E + +E + +EK++ I+++ E+
Sbjct: 948 SETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDER 1007
Query: 1031 ETKLGNESSMDKAKKSI-------TNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHL 1083
E + S K +K I T + +S+K + K C + E+
Sbjct: 1008 EKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENR 1067
Query: 1084 RTSLKQMEE------RNFELETKFAELTKIN--LDAQKVEQMLRDELADSVSKAVSDAD- 1134
+ L+Q++E + F + FAE N L+ + V+Q LR E+ D+ + + S+A
Sbjct: 1068 KNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGG 1127
Query: 1135 -RQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQ 1193
+Q I+ L++ + +++ EV+ L + ++ + ++++ + + ++ E E +R + + +++
Sbjct: 1128 LKQEIMTLKEEQNKMQKEVNDLLQENE---QLMKVMKTKHECQNLESEPIRNSVKERESE 1184
Query: 1194 SDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYAR 1253
++ + + + L++ E + L+S ++L ++EA E KL E E+
Sbjct: 1185 RNQCNF-----KPQMDLEVKEIS----LDSYNAQLVQLEAMLRNKELKLQESEKE----- 1230
Query: 1254 LEGRNRAKHLRQTIQSLRRQFSGALPLAQQE--KFSKTMIQLQNDKLKIMQEMKNSQQEH 1311
+ +H QTI+ + S + QE I + + E+ SQ ++
Sbjct: 1231 ---KECLQHELQTIRG-DLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDN 1286
Query: 1312 RNME-------NKTLEMELKLKGLE----ELISTLKDT---------KGAQKVINWHMKI 1351
+++ NK E+E + L+ EL++ L D+ K A++V ++
Sbjct: 1287 AHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEV 1346
Query: 1352 EELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAW---- 1407
+ L L+ ELV+D ++ ++ +++ L+E ++ ++++
Sbjct: 1347 KILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAE 1406
Query: 1408 -DQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRI 1466
++ + L+ + I Q ++ + + + S+ +L L L + + +++
Sbjct: 1407 LQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQL 1466
Query: 1467 ILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKE 1526
LE SL S+L + R + + L + E + E
Sbjct: 1467 GLE-EGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDE 1525
Query: 1527 MEPKSHHTLKIAHQTIANMQAR-LNQKEEVLKKYQRLLEKARE--EQREIVKKHE-EDLH 1582
+ S + + + A+ + + E + + Y++ LEK E E + I+K E ++L
Sbjct: 1526 VFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELE 1585
Query: 1583 ILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLV 1642
L E Q L K + + +Q T V AE +QT + SL +
Sbjct: 1586 QLLSS-ERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQT---EQLSLELEVA 1641
Query: 1643 KLKKVSQDLERQREITELKVKEF---ENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQK 1699
+L+ DL R + + ++ N + + H E + + D+ + D+ +
Sbjct: 1642 RLQLQGLDLS-SRSLLGIDTEDAIQGRNESCDISKEHTSETTE-RTPKHDVHQICDKDAQ 1699
Query: 1700 ESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAA 1759
Q L +++ E + PT + E + + S + EL A
Sbjct: 1700 --QDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNAL 1757
Query: 1760 EERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNL 1819
+ D H +L+ + E NEN L+L ++ + SL + +
Sbjct: 1758 VPMDFLGNQE-----------DIHNLQLRVK-ETSNEN-LRLLHVIEDRDRKVESLLNEM 1804
Query: 1820 NDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQR 1879
+L+++L ++ + E+++ ELK++ L+ L+ + + Q L++ ++
Sbjct: 1805 KELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLE--YFSCDHQELLQRVET 1862
Query: 1880 KVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTL 1939
+ L + LE ++ + + + AK W+ + + N+L E ++
Sbjct: 1863 S-EGLNSDLEMHADKSSREDIGDNVAK-------VNDSWKERFLDVENELSRIRSEKASI 1914
Query: 1940 TKQLNTLKDLFAKADKEKLTLQRKLKTTGMTV---DQVLGIRALESEK---ELEELKKRN 1993
+ L+ EKL L++ + + ++ L + E + EL+ + K+
Sbjct: 1915 EHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKT 1974
Query: 1994 LDLENDILYMRAHQALPRDSVVEDLH---LQNRYLQEKLHALEKQFSKDTYSKPSISGIE 2050
L+ M+ E LH + ++EK L+ T S ++
Sbjct: 1975 TALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQ------TLSSDVSELLK 2028
Query: 2051 SDDHCQRE-QELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAE 2109
H Q + Q L+K++ LS EL+ Q+ Q NK+ L + L+ EK
Sbjct: 2029 DKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLN 2088
Query: 2110 VQRKL-GHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQ 2168
V + L + G + ++ + +++ +EK++ E +K + +EK+ E+
Sbjct: 2089 VSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQ-LHIAEKLKERER 2147
Query: 2169 ENEKLKAELEKLKAHLGHQLS--------MHYESKTKGTEKIIAENERLRKELKKETDAA 2220
EN+ LK ++E L+ L Q+S + E+ E + + E + + LK
Sbjct: 2148 ENDSLKDKVENLEREL--QMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDL 2205
Query: 2221 EKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSK-SWKSIVVTRMYETKL 2279
LR K NL ++ QL E K L +S + E A+ + +S M + +L
Sbjct: 2206 VTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQL 2265
Query: 2280 KELETDIAK--KNQSI-----TDLKQLVKEATEREQKVNKYNEDLE----QQIKILKHVP 2328
KEL +A +Q I L ++E + + K LE +Q+ +L+ +
Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLK 2325
Query: 2329 EGAE-------TEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQL 2381
E + L+REL++ R ++E A L EA + E+ + +
Sbjct: 2326 ESEHHADLLKGRVENLERELEIAR-----TNQEHAAL----EAENSKGEVETLKAKIEGM 2376
Query: 2382 KEKIKDLETQLKMSDLEKQHLKEEIKKLKK---ELENFDPSF---FEEIEDLKYNYKEEV 2435
+ ++ LE + EK++L E++K ++ ELE + SF +E E K KE+
Sbjct: 2377 TQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKS 2436
Query: 2436 KKNI-LLEEKVKKLSEQL 2452
+ +L+ ++K+L+E++
Sbjct: 2437 STAMEMLQTQLKELNERV 2454
Score = 195 bits (496), Expect = 4e-49
Identities = 489/2447 (19%), Positives = 1008/2447 (41%), Gaps = 415/2447 (16%)
Query: 226 TEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQV 285
T A +KI QE+ L++ +E ++ + + ++A + + ++ K E + + +
Sbjct: 14 TRALQKI----QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKREN 69
Query: 286 QELTDLLKSKNEEDDPIMVAVNAKVEEWKLI---LSSKDDEIIEYQQMLHNLREKLKNAQ 342
Q L ++ +S + I + K + L+S +I + +Q L + +L+ +Q
Sbjct: 70 QRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQ 129
Query: 343 LDADKSNVMALQQGIQERDSQIKMLTEQV----------EQYTKEMEKNTCIIEDLKNEL 392
A ++V ++ + Q E+Y KE+E+ + ++K L
Sbjct: 130 QAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVK-AL 188
Query: 393 QRNKGASTLSQQT--------HMKIQSTLDILKEKT-----KEAERTAELAEADAR--EK 437
Q K + TL Q T H S +EKT ++RT + A
Sbjct: 189 QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSG 248
Query: 438 DKELVEALKRL----KDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKI 493
++E+ + L +D S + + + +Q+K +++E L +IN+LEL++
Sbjct: 249 EQEVTPSRSTLQIGKRDANSSFFDNSSS----PHLLDQLKAQNQE---LRNKINELELRL 301
Query: 494 SDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLK 553
G E + + +F+ L+ Q +A+ +++ KE + L + R +L
Sbjct: 302 Q-------------GHEKEMKGQVNKFQE---LQLQLEKAKVELIEKE-KVLNKCRDELV 344
Query: 554 KKIRQMAQERGKRSATSGLT---TEDLNLTENISQGDRIS-ERKL---DLLSLKNMSEAQ 606
+ Q Q K +A TEDL+ ++ R S E+K+ + + +S Q
Sbjct: 345 RTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQ 404
Query: 607 SKNEFLSRELIEKE----RDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAI---K 659
+ L +E I+ + ++L++++ + Q +L +L +QLE ++E Q + +
Sbjct: 405 RSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAE 464
Query: 660 EMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL 719
+ + +K E + +++ N ++S + + + HL+A++ +
Sbjct: 465 QAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVC-HLEAELKNI----------- 512
Query: 720 RESRKEAINYSQQLAKANLKIDHLEKETSL------LRQSEGSNVVFK---GIDLPDGIA 770
K+ +N SQ A+ +K + +ET L + Q E S + K + +
Sbjct: 513 ----KQCLNQSQNFAE-EMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQR 567
Query: 771 PSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEK 830
S ++ + ++ L +L EK+ K L +LE +++ ++ +++L + + SE
Sbjct: 568 DCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTL-FSCWKSEN 626
Query: 831 ETWKTESKTIKEEKRK----LEDQVQQDAIKVKEYNNLLNALQMDSDEMK---------- 876
E T+ ++ KE + LE ++ IK EYN + L+MD + +
Sbjct: 627 EKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL 686
Query: 877 --KILAENSRKITVLQVNEKSLIRQYTTLVELER------QLRKENEKQKNELLSMEAEV 928
K + ++K+ +++ +K+ E+E QL + E +++L + E+
Sbjct: 687 DSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEI 746
Query: 929 CEKIGCLQ-------RFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQ 981
+K C Q +++ K A+L D+ SL LA Q + + +I+
Sbjct: 747 MDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSL----LAFDQQPAMHHSFANIIG 802
Query: 982 KDNMLVQRTSNLEHLECE-----NISLKEQVESINKELEITKEKLHTIEQAWEQETKLGN 1036
+ + S LE + + L+ +V+S+ LE K+ +++ E+ ++
Sbjct: 803 EQGSMPSERSECR-LEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKG 861
Query: 1037 ESSMDKAK-KSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNF 1095
E + K + + S + S++I+ L+ ++ + Q + L K+++ N
Sbjct: 862 EIEENLMKAEQMHQSFVAETSQRISKLQ-EDTSAHQNV--VAETLSALENKEKELQLLND 918
Query: 1096 ELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEME-LKVEVSK 1154
++ET+ AE+ ++ +E L++ S + ++ + I+ L K E+E L E
Sbjct: 919 KVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGT 978
Query: 1155 LREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSE 1214
L+EI+ ++ L + +S ++ + + Q ++ LI LQ E
Sbjct: 979 LKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL--------LQRCE 1030
Query: 1215 ATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQF 1274
T E ++ K + + N +LE L+E +N + L++ ++F
Sbjct: 1031 ETG-NAYEDLSQKYKAAQEKNSKLECLLNECTSLCE----NRKNELEQLKEAFAKEHQEF 1085
Query: 1275 SGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELIST 1334
L A+ E+ M++L+ + + EM ++Q ++ + GL++ I T
Sbjct: 1086 LTKLAFAE-ERNQNLMLELETVQQALRSEMTDNQNNSKS----------EAGGLKQEIMT 1134
Query: 1335 LKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIV 1394
LK+ + + ++ +L LQE + +++K K E + L E E +S++E
Sbjct: 1135 LKEEQNKMQ-----KEVNDL-LQENEQLMKVMKTKHECQNL-----ESEPIRNSVKERES 1183
Query: 1395 QQNKFHEERQMAWDQREVDLER------QLDIFDRQQNEILNAAQKFEEATGSIPDPSLP 1448
++N+ + + QM + +E+ L+ QL+ R + L ++K +E
Sbjct: 1184 ERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKEC---------- 1233
Query: 1449 LPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLR 1508
L+ + IR LET +L++ ++ S L+ E +
Sbjct: 1234 --------LQHELQTIRGDLET----SNLQDMQSQEISGLKDCEIDA------------- 1268
Query: 1509 LPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLK--KYQRLLE-- 1564
EK I+ + L+ + QT N L + E+L+ KY+ + E
Sbjct: 1269 ------EEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELN 1322
Query: 1565 KAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLA 1624
+R E +K E++ L + +++ D S + D+ P +H + LA
Sbjct: 1323 DSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLA 1382
Query: 1625 EMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHE---DEVK 1681
++++ + + +LS D E Q EL+ K L LQ H+ D+
Sbjct: 1383 PLDESNSYEHLTLS-----------DKEVQMHFAELQEKF-----LSLQSEHKILHDQHC 1426
Query: 1682 KVKAEVEDLKYLLDQSQKESQCLKSELQA-QKEANSRAPTTTMRNLVERLKSQL-----A 1735
++ +++ +L+ +D + E+ L + L+ Q + LV L S +
Sbjct: 1427 QMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSS 1486
Query: 1736 LKEKQQKALSRALLELRAEMTAAAE-ERIISA----------TSQKEAHLNVQQIVD--- 1781
L + RALLE +M+ + E +SA +S +E +L ++
Sbjct: 1487 LSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPA 1546
Query: 1782 RHTRELKTQVEDLNENLLKLKEALKTS---KNRE-NSLTDNLNDLNNELQKKQKAYNKIL 1837
+ EL++ E ++L KL+E +++ KN+E L L+ EL +K Y
Sbjct: 1547 KGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLS-- 1604
Query: 1838 REKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDL 1897
EN++ ++++ +T ++ K + KQ+ E+L +++ QL+G +DL
Sbjct: 1605 --------ENEQWQQKLTSVTLEMESKLAAEKKQT--EQLSLELEVARLQLQG----LDL 1650
Query: 1898 KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADK-- 1955
+ L+ G + I+G RN+ + E + T + D+ DK
Sbjct: 1651 -------SSRSLL----GIDTEDAIQG-RNESCDISKEHTSETTERTPKHDVHQICDKDA 1698
Query: 1956 --------EKLTLQRKLKTTGMTVDQVLGIRALESEKEL--EELKKRNLDLENDILYMRA 2005
EK+T +K TG + G ++ ++ E E+ + + + +++ +
Sbjct: 1699 QQDLNLDIEKITETGAVKPTG----ECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGP 1754
Query: 2006 HQALPRDSVVEDLHLQNRYLQEK---------LHALEKQFSKDTYSKPSISGIESDDHCQ 2056
+ +P D + + N L+ K LH +E + K + ++S H Q
Sbjct: 1755 NALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQ 1814
Query: 2057 REQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGH 2116
Q + K IE +LE K + LK + DL E E+ + E+ +++
Sbjct: 1815 EVQLMTK---------IEACIELE---KIVGELKKENSDLSEKLEYFSCDHQELLQRVET 1862
Query: 2117 VRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAE 2176
G E+ + + + V + N+ K E+ ++E E ++++E
Sbjct: 1863 SEGLNSD----LEMHADKSSREDIGDNVAKVNDSWK--------ERFLDVENELSRIRSE 1910
Query: 2177 LEKLKAHLGHQ-LSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNE 2235
KA + H+ L + + + TEK+ E + K+ K E+L + + L
Sbjct: 1911 ----KASIEHEALYLEADLEVVQTEKLCLEKDNENKQ-KVIVCLEEELSVVTSERNQLRG 1965
Query: 2236 KMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITD 2295
++ ++T Q +E + + +S + + ++ E ++KE +T++ + S D
Sbjct: 1966 ELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKE-KTELLQTLSS--D 2022
Query: 2296 LKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQV------------ 2343
+ +L+K+ T ++K+ +D Q + + K E + ++EL V
Sbjct: 2023 VSELLKDKTHLQEKLQSLEKD-SQALSLTKCELENQIAQLNKEKELLVKESESLQARLSE 2081
Query: 2344 -----------------------LRLAN-----HQLDKEKAELIHQIEANKDQS-----G 2370
LRL++ HQL + +L +IEA++ +
Sbjct: 2082 SDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEK 2141
Query: 2371 AESTIPDADQLKEKIKDLETQLKMSD-------LEKQHLKEEIKKLKKELENFDPSFFEE 2423
+ + D LK+K+++LE +L+MS+ L+ ++ K E++ LK ++E S
Sbjct: 2142 LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVF 2201
Query: 2424 IEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEE 2470
DL E+ ++EK +LSE L L+S + EE E E
Sbjct: 2202 ELDLVTLRSEKENLTKQIQEKQGQLSE-LDKLLSSFKSLLEEKEQAE 2247
Score = 129 bits (324), Expect = 4e-29
Identities = 263/1168 (22%), Positives = 501/1168 (42%), Gaps = 207/1168 (17%)
Query: 17 DLPRQEELADNLLISLSKVEVNELKSEK---QENVIHLFRITQSLMKMKAQEVELALEEV 73
D +E++ DN+ +VN+ E+ EN + R ++ ++ +A +E LE V
Sbjct: 1875 DKSSREDIGDNV------AKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV 1928
Query: 74 --EKAGEEQAKFENQLKTKVMK-LENELEMA----QQSAGGRDTRFLRNE-ICQLEKQLE 125
EK E+ +N+ K KV+ LE EL + Q G DT + + QL ++++
Sbjct: 1929 QTEKLCLEK---DNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMK 1985
Query: 126 QKDRELEDMEKEL-----EKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDI 180
+K +ELE + E E +V E+ L + ++ S+L ++ L++K + L +D
Sbjct: 1986 EKTQELESHQSECLHCIQVAEAEVKEKTELL-QTLSSDVSELLKDKTHLQEKLQSLEKD- 2043
Query: 181 IDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQT-LTEAN-EKIEVQNQE 238
+ L + E + +QL+K+ L++ + +Q L+E++ EK+ V
Sbjct: 2044 ----------SQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVS--- 2090
Query: 239 MRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEE 298
K LE ++ E + + + VHQ I++L+ + + + + + LK + E
Sbjct: 2091 --KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERE 2148
Query: 299 DDPIMVAVNAKVE--EWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDAD--KSNVMALQ 354
+D ++ KVE E +L +S ++ E++ LDA+ K+ V L+
Sbjct: 2149 ND----SLKDKVENLERELQMSEENQELV----------------ILDAENSKAEVETLK 2188
Query: 355 QGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLD 414
I+E +K+ +++ T EK E+L ++Q +G S LD
Sbjct: 2189 TQIEEMARSLKVF--ELDLVTLRSEK-----ENLTKQIQEKQGQ-----------LSELD 2230
Query: 415 ILKEKTKEAERTAELAEADAREKDKELVEALK-RLKDYESGVYGLEDAVVEIKNCKNQIK 473
L K E AE +E+ K VE L+ +LK+ L +AV + + +K
Sbjct: 2231 KLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKE-------LNEAVAALCGDQEIMK 2283
Query: 474 IRDREIEILTKEINKLELKISDFLDENEALRERVGL-EPKTMIDLTEFRNSKH----LKQ 528
++ ++ +E ++L I E LR R+ E K + L + + S+H LK
Sbjct: 2284 ATEQSLDPPIEEEHQLRNSI-------EKLRARLEADEKKQLCVLQQLKESEHHADLLKG 2336
Query: 529 QQYRAENQILLK---------EIESLEEERLDLKKKIRQMAQE-RGKRSATSGLTTEDLN 578
+ E ++ + E E+ + E LK KI M Q RG + +E N
Sbjct: 2337 RVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEN 2396
Query: 579 LTENI-SQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKL 637
LT + + +RISE ++ S +N+ + + + EK + E+S T + Q +L
Sbjct: 2397 LTNELQKEQERISELEIINSSFENILQEKEQ---------EKVQMKEKSSTAMEMLQTQL 2447
Query: 638 KELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDA 697
KEL E L +A K K+ ++ L + + L E+KN + +
Sbjct: 2448 KELNERVAALHNDQ----EACK--AKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQS 2501
Query: 698 SLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSN 757
S++ L QE+ + +++ +++++ +I E+ S L Q EG +
Sbjct: 2502 SVN-------------GLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEH 2548
Query: 758 VVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRH 817
++K QN L +L ELE K + L++ SL+D
Sbjct: 2549 QLWK-----------------EQNLELRNLTVELEQKIQVLQSKNASLQD---------- 2581
Query: 818 QQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKK 877
+L Y + + E + K +K ++V + K E ++ + + E+++
Sbjct: 2582 TLEVLQSSY----KNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQE 2637
Query: 878 ILA-ENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQ 936
L+ E +R LQ+ L+ + + + ++L EN + K L M + EK G ++
Sbjct: 2638 ELSGEKNRLAGELQL----LLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVR 2693
Query: 937 RFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRD-ILQKDNMLVQRTSNLEH 995
+E+A +++ + + L + NKQY YR+ + K+ L + ++
Sbjct: 2694 --EEIAEYQLRLHEAEKKHQALLLD---TNKQYEVEIQTYREKLTSKEECLSSQKLEIDL 2748
Query: 996 LECENISLKEQVESINKEL-EITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVS 1054
L+ L +++ + L E+ K K+ ++ + + K NE + K K I + +
Sbjct: 2749 LKSSKEELNNSLKATTQILEELKKTKMDNLK--YVNQLKKENERAQGKMKLLIKSCKQLE 2806
Query: 1055 ISKKITMLEMKELNERQRAEHCQK-------MYEHLRTSLKQ----MEERNFELE---TK 1100
K+I KEL++ Q A+ QK + L T +K+ +EE+ E + K
Sbjct: 2807 EEKEIL---QKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDK 2863
Query: 1101 FAELTKINLDAQKVEQMLRDELADSVSK 1128
+ L + +K ++ML ++A S+
Sbjct: 2864 YCSLLISHEKLEKAKEMLETQVAHLCSQ 2891
Score = 106 bits (264), Expect = 3e-22
Identities = 141/645 (21%), Positives = 301/645 (46%), Gaps = 83/645 (12%)
Query: 8 KEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQS-----LMKMK 62
+EIMK L E L S+ K+ L++++++ + L ++ +S L+K +
Sbjct: 2279 QEIMKATEQSLDPPIEEEHQLRNSIEKLRAR-LEADEKKQLCVLQQLKESEHHADLLKGR 2337
Query: 63 AQEVELALEEVEKAGEEQAKFENQ-LKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLE 121
+ +E LE + + +E A E + K +V L+ ++E QS G LE
Sbjct: 2338 VENLERELE-IARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRG------------LE 2384
Query: 122 KQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDII 181
+ E E++ EL+KE++ +L + N EN + +E ++K+K+ + +
Sbjct: 2385 LDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQ 2444
Query: 182 DYQKQIDSQKETLLSR----RGEDSDYRSQ---LSKKNYELIQYLDEIQTLTEANEKIEV 234
K+++ + L + + ++ + SQ L + +L+Q LDE + N I +
Sbjct: 2445 TQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAK-----NNYIVL 2499
Query: 235 QNQE--MRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLL 292
Q+ + + +E+ Q++EK +E +R+K + + ++ +L + +QL
Sbjct: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLW-------- 2551
Query: 293 KSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMA 352
K +N E + V + K++ +L SK+ + + ++L + + L+N +L+ K + M+
Sbjct: 2552 KEQNLELRNLTVELEQKIQ----VLQSKNASLQDTLEVLQSSYKNLEN-ELELTKMDKMS 2606
Query: 353 LQQGIQE---RDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKI 409
+ + + ++++++ ++ Q T E++ E+L E R G L + +I
Sbjct: 2607 FVEKVNKMTAKETELQREMHEMAQKTAELQ------EELSGEKNRLAGELQLLLE---EI 2657
Query: 410 QSTLDILKEKT---KEAERTAELAEADAREKD----KELVEALKRLKDYESGVYGL---- 458
+S+ D LKE T E +++ + D EK+ +E+ E RL + E L
Sbjct: 2658 KSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDT 2717
Query: 459 -EDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDL 517
+ VEI+ + ++ ++ + EI+ L+ + + +A + + KT +D
Sbjct: 2718 NKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDN 2777
Query: 518 TEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQM--AQERGKR-----SATS 570
++ N + ++ + + ++L+K + LEEE+ L+K++ Q+ AQE+ K +
Sbjct: 2778 LKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVD 2837
Query: 571 GLTTEDLNLTENISQGDRISERKLD-----LLSLKNMSEAQSKNE 610
LTTE L E + + + ++ LD L+S + + +A+ E
Sbjct: 2838 ELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLE 2882
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 243 bits (619), Expect = 2e-63
Identities = 485/2400 (20%), Positives = 1010/2400 (42%), Gaps = 391/2400 (16%)
Query: 163 RRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQL-----SKKNYELIQ 217
++ +++ ++ +QL Q + Q +S T + R S + QL ++++ +
Sbjct: 3 KKLKQKISEEQQQLQQALAPAQASSNSSTPTRM--RSRTSSFTEQLDEGTPNRESGDTQS 60
Query: 218 YLDEIQTLTEANEKI---EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQL 274
+ ++Q + E + ++ R + +ES+ + NR+ +D
Sbjct: 61 FAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSR-ESLNRLD---------LDSS 110
Query: 275 KKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNL 334
D E DL+ + + + ++ ++E K E++ QML
Sbjct: 111 TASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQRE 170
Query: 335 REKLKNAQLDA-DKS--NVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNE 391
++KL+ + DKS + L++ +Q K L E+ + +E ++ +++ +
Sbjct: 171 KKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSL 230
Query: 392 LQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELV----EALKR 447
L++ ++ +D+LK + + + + E D E V ++K
Sbjct: 231 LKQRLRNGPMN----------VDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKT 280
Query: 448 LKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERV 507
L+ + V E+ +K CK I+ + +LT E L+ ++ + L E E +++ +
Sbjct: 281 LETLQQRVKRQENL---LKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKD-L 336
Query: 508 GLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKE-------IESLEEERLDLKKKIRQMA 560
+ KT + +T+ R++K+L +Q + + ++ + +E EEE L+ +I+QM
Sbjct: 337 HMAEKTKL-ITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMT 395
Query: 561 QE----RGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSREL 616
+ R ++ + E+L + +Q + RKL + + + +E E
Sbjct: 396 TQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE---EER 452
Query: 617 IEKERDLER-SRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLI 675
I +++L R + V+ + +E + + ++L E KE+ + +E+ K + E
Sbjct: 453 ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE--KELARKEQELTKKLQTREREFQ-- 508
Query: 676 IPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAK 735
E++ A+E +E + ++ Q + E L E E +K+AI L +
Sbjct: 509 ----EQMKVALEKSQSEYL---------KISQEKEQQESLALEELELQKKAI-----LTE 550
Query: 736 ANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKE 795
+ K+ L++E R + ++L + S N + +HL E K
Sbjct: 551 SENKLRDLQQEAETYRT--------RILELESSLEKSLQENKNQSKDLAVHLEAE---KN 599
Query: 796 KKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSE-KETWKTESKTIKEEKRKLEDQVQQD 854
K K + +E + + ++HQQ L+ E L K+ ++TE + ++E+ +Q ++
Sbjct: 600 KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKC----EQEKET 655
Query: 855 AIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKEN 914
+K KE Q +EM + E K+ V Q +SL + + +++ +L +E
Sbjct: 656 LLKDKEI-----IFQAHIEEMNEKTLE---KLDVKQTELESLSSELSEVLKARHKLEEEL 707
Query: 915 EKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANK-QYNELT 973
K++ M+ E+ K+ + + + I + ++ VS+ E A K Q N+L
Sbjct: 708 SVLKDQTDKMKQELEAKMDEQKNHHQQQVDSI-----IKEHEVSIQRTEKALKDQINQLE 762
Query: 974 AKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETK 1033
++ +D L + +++E+LE + + +++ + +L++ + + A ++TK
Sbjct: 763 LLLKE---RDKHLKEHQAHVENLEADIKRSEGELQQASAKLDV----FQSYQSATHEQTK 815
Query: 1034 LGNESSMDKAKKSIT-NSDIVSISKKITMLEMKELNERQRAEHCQKMYEH---LRTSLKQ 1089
E +K + ++ + ++K++ +E Q+ + C ++ H ++ ++Q
Sbjct: 816 AYEEQLAQLQQKLLDLETERILLTKQVAEVEA------QKKDVCTELDAHKIQVQDLMQQ 869
Query: 1090 MEERNFELETKFAELTKI--------NLDAQKVEQML--------------RDELADSVS 1127
+E++N E+E K LT++ N + ++ +Q+L + E+
Sbjct: 870 LEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQ 929
Query: 1128 KAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNA----QQQSRDKEVESL 1183
K + D IL E+ E + K + K+ ++ A+ E L Q+ KE+E+
Sbjct: 930 KLSAKEDSIHILN-EEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENT 988
Query: 1184 RMQLLDYQAQSDEKSL-IAKLHQHNVSLQLS--EATALGKLESITSKLQK-----MEAYN 1235
++L + Q + K L +A+ + +S +S E ++ES+T ++ + +
Sbjct: 989 ALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWE 1048
Query: 1236 LRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQN 1295
+L Q+ +E ++ E L+Q I L ++E+ +K + L+
Sbjct: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKI---------LLFGCEKEEMNKEITWLKE 1099
Query: 1296 DKLK-------IMQEMKNSQQEHRNMENKTLEMELKLKGLE-ELISTLKDTKGAQK-VIN 1346
+ +K + +++K ++ +++ L+ LE +L +LK+ Q+ ++
Sbjct: 1100 EGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE 1159
Query: 1347 WHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMA 1406
M EE + + +L +L EE + L S +E++ SLE++ ++ K EE +
Sbjct: 1160 LKMLAEEDKRKVSELTSKLKTTDEEFQSLK---SSHEKSNKSLEDKSLEFKKLSEELAIQ 1216
Query: 1407 WD----QREVDLERQ----LDIFDRQQNEILNAAQKFEEATGSIPDPSLPLP---NQLEI 1455
D + E LE + ++I + N IL+ + T + + L ++LE
Sbjct: 1217 LDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEA 1276
Query: 1456 ALRKIKENIRII-LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAE 1514
LR++ E + + + LEEK + +S E + ++ + E + A +E
Sbjct: 1277 QLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASE 1336
Query: 1515 REKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIV 1574
+E I +L ++ E + TL M+ L +K+ + + L + + +
Sbjct: 1337 KESCITQLKKELSENINAVTL---------MKEELKEKKVEISSLSKQLTDLNVQLQNSI 1387
Query: 1575 KKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQD 1634
E++ I L Q D + DL + T L++ + + EQ
Sbjct: 1388 SLSEKEAAI--SSLRKQYDEEKCELLDQVQDLSFKVDT----------LSKEKISALEQV 1435
Query: 1635 DSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLL 1694
D S+ + KK +Q Q + T VKE + I+L+L+ E + ++ LK L
Sbjct: 1436 DDWSNKFSEWKKKAQSRFTQHQNT---VKELQ-IQLELKSK---EAYEKDEQINLLKEEL 1488
Query: 1695 DQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAE 1754
DQ K CLK E++ K + + NL LKSQ A ++EL
Sbjct: 1489 DQQNKRFDCLKGEMEDDKSKMEKKES----NLETELKSQTA-----------RIMELEDH 1533
Query: 1755 MTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENS 1814
+T ++ I S E N Q D +EL +++ E + +K ++ + +
Sbjct: 1534 IT----QKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILT 1589
Query: 1815 LTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLI 1874
L + + + EL+ K+K E++ N +K + + L K L D +S
Sbjct: 1590 LENQVYSMKAELETKKK----------ELEHVNLSVKSKEEEL------KALEDRLES-- 1631
Query: 1875 EELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEG 1934
E K+ +L+ + E K+ + + + + KEE + K ++ + + KL+E+E
Sbjct: 1632 -ESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYK----KGTESHLSELNTKLQERER 1686
Query: 1935 EVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEE---LKK 1991
EV L ++L +++ + E L + R K +Q +K EE + +
Sbjct: 1687 EVHILEEKLKSVES----SQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQ 1742
Query: 1992 RNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIES 2051
RNL E + L R Q ++V ++ +Y QE+L LE +K + I ++
Sbjct: 1743 RNLT-EKEKLLQRVGQE-KEETVSSHFEMRCQY-QERLIKLEHAEAKQHEDQSMIGHLQ- 1798
Query: 2052 DDHCQREQELQKENLKLS------------SENIELKFQLEQANKDLPRLKNQVRDLKEM 2099
+EL+++N K S NI+ K LE D+ + + KE+
Sbjct: 1799 -------EELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQE----KEL 1847
Query: 2100 -CEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKV----VEKVQRENEQLKKA 2154
C+ L+++ I EL+ + K+V +E++ + E+L+
Sbjct: 1848 TCQILEQK--------------------IKELDSCLVRQKEVHRVEMEELTSKYEKLQAL 1887
Query: 2155 SGILTSEKMANIEQENEKLKAELEKLKAHLGH-QLSMHYESKTKGTEKIIAENERLRKEL 2213
+ K + +EN + EK K+HL +L + E++ E +A ER +++L
Sbjct: 1888 QQMDGRNKPTELLEENTE-----EKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKL 1942
Query: 2214 KKETDAAEK-LRIAKNN----LEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKS 2268
KE +K LR+ + LEIL ++ + EE K+ Q LE + + K
Sbjct: 1943 GKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQ------EDLELKHNSTLKQ 1996
Query: 2269 IVVTRMYETKLKELETDIAKKNQSIT-DLKQLVKEATEREQKVNKYNEDLEQQIKILKHV 2327
+ ++E T +A+K Q + +K+ + +A E E ++ + ++ E+ ++LK +
Sbjct: 1997 L---------MREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQ--EETNQLLKKI 2045
Query: 2328 PEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKD 2387
AE + LKR K E++ E +++ K++D
Sbjct: 2046 ---AEKDDDLKRTA-----------KRYEEILDARE---------------EEMTAKVRD 2076
Query: 2388 LETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKK 2447
L+TQ L+E KK +++LE + + + ++ + K ++ + K+K+
Sbjct: 2077 LQTQ----------LEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE 2126
Score = 225 bits (574), Expect = 4e-58
Identities = 427/2057 (20%), Positives = 899/2057 (43%), Gaps = 328/2057 (15%)
Query: 30 ISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQ-EVELALEEVEKAGEEQAKFENQLK 88
IS+ + +V+ LK + +++ + + L +++ Q EV E E GE + +K
Sbjct: 221 ISVLQTQVSLLKQRLRNGPMNV-DVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVK 279
Query: 89 T------KVMKLENELEMAQQSAGGRDTR--FLRNEICQLEKQLEQKDRELEDMEKEL-- 138
T +V + EN L+ +++ + L +E L++QL+++ +ELE + K+L
Sbjct: 280 TLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKI-KDLHM 338
Query: 139 -EKEKKVNEQLALRN--EEAENENSKLRRENKR-----LKKKNEQLCQDIIDYQKQIDSQ 190
EK K + + +N E+ E + + E KR L+ K E++ Q + KQ+ +Q
Sbjct: 339 AEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQ-LRSRIKQMTTQ 397
Query: 191 KETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEE-SVQE 249
E L R ++ R+ EL + L Q EA K++ + E K +E+ S +E
Sbjct: 398 GEEL--REQKEKSERAAFE----ELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEE 451
Query: 250 MEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQ------------ELTDLLKSKNE 297
+ E +R+K V+D +KK ++ ++Q ELT L+++
Sbjct: 452 RISLQQELSRVK------QEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTRER 505
Query: 298 E-DDPIMVAVNAKVEEWKLILSSKDD------EIIEYQQ--MLHNLREKLKNAQLDAD-- 346
E + + VA+ E+ I K+ E +E Q+ +L KL++ Q +A+
Sbjct: 506 EFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETY 565
Query: 347 KSNVM----ALQQGIQERDSQIKMLTEQVE-QYTKEMEKNTCIIEDLKNELQRNKGASTL 401
++ ++ +L++ +QE +Q K L +E + K ++ T ++E K EL+ +L
Sbjct: 566 RTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELE------SL 619
Query: 402 SQQTHMKIQSTLDILKEKTK-EAERTAELAEADARE--KDKELVEALKRLKDYESGVYGL 458
Q L +LK++ + E E+ E E + KDKE++ +++ + +
Sbjct: 620 KHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEII--------FQAHIEEM 671
Query: 459 EDAVVEIKNCKN-QIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDL 517
+ +E + K +++ E+ + K +KLE ++S D+ + +++ LE K +
Sbjct: 672 NEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE--LEAK----M 725
Query: 518 TEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDL 577
E +N + E+++ ++ E +++++ ++ + +ER K E+L
Sbjct: 726 DEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQIN---QLELLLKERDKHLKEHQAHVENL 782
Query: 578 NLTENISQGD-RISERKLDLL-SLKNMSEAQSKN-EFLSRELIEKERDLERSRTVIAK-- 632
S+G+ + + KLD+ S ++ + Q+K E +L +K DLE R ++ K
Sbjct: 783 EADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQV 842
Query: 633 --------------------FQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGET 672
Q+ +++L ++N ++E+ +K + Q + +D + + +T
Sbjct: 843 AEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQT 902
Query: 673 SLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELR--ESRKEAINYS 730
I+ E ++ + + I + L A+ D + NEE + + E + E +
Sbjct: 903 KQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQK 962
Query: 731 QQLAKANLKIDHLEKETSLLRQSEGSNVVF---------KGIDLPD----GIAPSSASII 777
+ + LK L++E L ++ E + + K +++ GI+ + + +
Sbjct: 963 AKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLE 1022
Query: 778 NSQNEYLIHLLQ----ELENK----EKKLKNLEDSLEDYN------RKFAVIRHQQSLLY 823
+Q E + L + EL + EKKL + L++ + ++ V +Q +L
Sbjct: 1023 TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILL 1082
Query: 824 ----KEYLSEKETWKTES-----KTIKEEKRKLEDQ------VQQDAIKVKEYNNLLNA- 867
KE ++++ TW E T+ E + +L+ + + QD K+K + L
Sbjct: 1083 FGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVD 1142
Query: 868 ----------LQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENE-- 915
LQ E+K + E+ RK++ L K+ ++ +L + K E
Sbjct: 1143 LNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDK 1202
Query: 916 ----KQKNELLSMEAEVC-EKIGCLQRFKEMAIFKIAA---------LQKVVDNSVSLSE 961
K+ +E L+++ ++C +K L K + I++ + + + E
Sbjct: 1203 SLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKE 1262
Query: 962 -LELANKQYNELTAKYRDILQKDNML----VQRTSNLEHLECENISLKEQVESINKELEI 1016
L + +EL A+ R + ++ N L Q T LE E + S+K +ES+ E E
Sbjct: 1263 ALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA 1322
Query: 1017 TKEKLHTIEQAWEQETKLGNESSMDKAKKSITNS----------------DIVSISKKIT 1060
+++ +QA ++ ES + + KK ++ + +I S+SK++T
Sbjct: 1323 LQKEGGNQQQAASEK-----ESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT 1377
Query: 1061 MLEMK-----ELNERQRA-EHCQKMYEHLRTSL-KQMEERNFELETKFAELTKINLDAQK 1113
L ++ L+E++ A +K Y+ + L Q+++ +F+++T L+K + A
Sbjct: 1378 DLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDT----LSKEKISA-- 1431
Query: 1114 VEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQ 1173
+EQ+ D+ ++ S+ A + R + + EL++++ + + Q+ +L +
Sbjct: 1432 LEQV--DDWSNKFSEWKKKA-QSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEEL 1488
Query: 1174 QSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA-LGKLES-ITSKLQKM 1231
++K + L+ ++ D +++ ++K + N+ +L TA + +LE IT K ++
Sbjct: 1489 DQQNKRFDCLKGEMEDDKSKMEKK-------ESNLETELKSQTARIMELEDHITQKTIEI 1541
Query: 1232 EAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMI 1291
E+ N L+ +K+ +E + + L Q Q L + + A+++ ++
Sbjct: 1542 ESLNEVLKNYNQQKD-------IEHKELVQKL-QHFQELGEEKDNRVKEAEEK-----IL 1588
Query: 1292 QLQND--KLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHM 1349
L+N +K E K + EH N+ K+ E ELK LE+ + + K A+
Sbjct: 1589 TLENQVYSMKAELETKKKELEHVNLSVKSKEEELK--ALEDRLESESAAKLAELKRKAEQ 1646
Query: 1350 KIEELRLQELKLNRELVKD-----KEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQ 1404
KI ++ Q L E + + + LN + E ER + LEE++ E
Sbjct: 1647 KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL 1706
Query: 1405 MAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENI 1464
+ + ++++ + QK E S+ +L +L + + KE
Sbjct: 1707 IV----PRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKE-- 1760
Query: 1465 RIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLI-AELG 1523
ET ++ + + +E+ L AE +I L+ L ++ LI A+
Sbjct: 1761 ----ETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHV 1816
Query: 1524 RKEMEPKSHHTLKIAHQTIANMQARLNQKE---EVLKKYQRLLEKAREEQREIVKKHEED 1580
KE + + ++Q L +KE ++L++ + L+ Q+E+ + E+
Sbjct: 1817 EKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEE 1876
Query: 1581 LHILHHRLE-LQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIR---LAEMEQTVAEQDDS 1636
L + +L+ LQ NK +L++++ T + H ++ L+ ME + +
Sbjct: 1877 LTSKYEKLQALQQMDGRNK----PTELLEEN-TEEKSKSHLVQPKLLSNMEAQHNDLEFK 1931
Query: 1637 LSSLLVKLKKVSQDLER-QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLD 1695
L+ + +K+ +++ R Q+++ L+ + + +++ +E ++ +K+K E EDL+
Sbjct: 1932 LAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLE---- 1987
Query: 1696 QSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEM 1755
LK +T++ L+ +QLA KE++ + + + E+
Sbjct: 1988 --------LKH-------------NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEV 2026
Query: 1756 TAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSL 1815
A E + Q+E + +++I ++ +DL + +E L RE +
Sbjct: 2027 EAELLE-----SHQEETNQLLKKIAEKD--------DDLKRTAKRYEEILDA---REEEM 2070
Query: 1816 TDNLNDLNNELQKKQKAYNKILREKEEIDQEN---DELKRQIKRLTSGLQGKPLTDNK-Q 1871
T + DL +L++ QK Y + L ++E +N EL+ Q+ + T+ + L + + +
Sbjct: 2071 TAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFR 2130
Query: 1872 SLIEELQRKVKKLENQL 1888
I L+ ++KK E +
Sbjct: 2131 EQIHNLEDRLKKYEKNV 2147
Score = 221 bits (563), Expect = 7e-57
Identities = 418/2044 (20%), Positives = 868/2044 (42%), Gaps = 291/2044 (14%)
Query: 533 AENQILLKEIESLEEERL--DLKKKIRQMAQERGKRS----ATSGLTTEDLNLTENISQG 586
+E + L+ +SL +E+L L++ R ++ RGK S A L E L +SQ
Sbjct: 122 SEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQS 181
Query: 587 DRISERKLDLLSLKNMSEAQSKN---EFLSRELIEKERDLERSRTVIAKFQNKLK----- 638
S R++ L + + Q+K E L EK++ + +T ++ + +L+
Sbjct: 182 QDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMN 241
Query: 639 -ELVEENKQLEEGMKEILQAIK-EMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696
++++ QLE + + E +P V+ G + + +L++ V E+
Sbjct: 242 VDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKET 301
Query: 697 ASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGS 756
H K Q LT E L+++L E +E +K H+ ++T L+ Q +
Sbjct: 302 IQSH-KEQCTLLTSEKEALQEQLDERLQEL---------EKIKDLHMAEKTKLITQLRDA 351
Query: 757 NVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIR 816
+ + ++ G+ + ++ + +H + LE KE+++ L ++ + +R
Sbjct: 352 KNLIEQLEQDKGM-------VIAETKRQMH--ETLEMKEEEIAQLRSRIKQMTTQGEELR 402
Query: 817 HQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMK 876
Q+ + E E + ++ +E +RKL+ ++ + + ++ S+E +
Sbjct: 403 EQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQ----------IKTIEKTSEEER 452
Query: 877 KILAENSRKIT--VLQVNEKSLIRQYTTLVEL-ERQLRKENEKQKNELLSMEAEVCEKIG 933
L + ++ V+ V +KS Q L +L E++L ++ ++ +L + E E E++
Sbjct: 453 ISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMK 512
Query: 934 CLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNL 993
+ KI+ +K S++L ELE LQK +L + + L
Sbjct: 513 VALEKSQSEYLKISQ-EKEQQESLALEELE----------------LQKKAILTESENKL 555
Query: 994 EHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIV 1053
L+ E + + ++ ELE + EK + ++ + E+ +K K IT V
Sbjct: 556 RDLQQEAETYRTRI----LELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEIT----V 607
Query: 1054 SISKKITMLE-MKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQ 1112
+ K T LE +K + E Q + + +T ++++ E+ Q
Sbjct: 608 MVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKC----------------EQ 651
Query: 1113 KVEQMLRDELADSVSKAVSDADRQRILE-LEKNEMELKVEVSKLREISDIARRQVEILNA 1171
+ E +L+D+ + + +A + ++ LE L+ + EL+ S+L E+ + E L+
Sbjct: 652 EKETLLKDK--EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSV 709
Query: 1172 QQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKM 1231
+ DK + L ++ D Q ++ + + + +H VS+Q +E
Sbjct: 710 LKDQTDKMKQELEAKM-DEQKNHHQQQVDSIIKEHEVSIQRTEKA--------------- 753
Query: 1232 EAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMI 1291
L+ ++++ E L + R KHL++ + L K S+ +
Sbjct: 754 ------LKDQINQLELLL-------KERDKHLKEHQAHVEN-------LEADIKRSEGEL 793
Query: 1292 QLQNDKLKIMQEMKNSQQEH-RNMENKTLEMELKLKGLEE----LISTLKDTKGAQKVIN 1346
Q + KL + Q +++ E + E + +++ KL LE L + + + +K +
Sbjct: 794 QQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVC 853
Query: 1347 WHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMA 1406
+ ++++Q+L ++ L SE E+ + SL + V ++K + +
Sbjct: 854 TELDAHKIQVQDL------------MQQLEKQNSEMEQKVKSLTQ--VYESKLEDGNKEQ 899
Query: 1407 WDQREVDLERQ---LDIFDRQQNEILNAAQKFEEATGSI----PDPSLPLPNQLEIALRK 1459
+++ +E++ L + + Q+ EI QK SI + NQ E + K
Sbjct: 900 EQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQ-EKKMEK 958
Query: 1460 IKENIRIILETRATCKSLEEKLKEKESALRLAEQN----ILSRDKVINELRLRLPATAER 1515
+K+ + + ET L++KL ++E+ L+ +N + ++K N L + A A
Sbjct: 959 VKQKAKEMQET------LKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM-AQANS 1011
Query: 1516 EKLIAELGRKEMEPKSH-HTLKIAHQ-----TIANMQARLNQKEEVLKKYQRL-LEKARE 1568
+ + R E K +L H+ I+ + +LNQ+ E L++ + L++ +
Sbjct: 1012 AGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071
Query: 1569 EQREI--------VKKHEEDLHILHHRLE-LQADSSLNKF----KQTAWDLMKQSPTPVP 1615
E E+ +K E + I + E ++ D++LN+ KQ + + +
Sbjct: 1072 EVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETK 1131
Query: 1616 TNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITEL--KVKEFENIKLQLQ 1673
H +L +++ L LV+LK +++ E +R+++EL K+K + L+
Sbjct: 1132 LKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAE--EDKRKVSELTSKLKTTDEEFQSLK 1189
Query: 1674 ENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQ 1733
+HE K ++ + + K L ++ + + +A EA + + + S+
Sbjct: 1190 SSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSR 1249
Query: 1734 LALKEKQQKALSRALL-------ELRAEMTAAAEER-IISATSQKEAHLNVQQIVDRHTR 1785
++ + + + ALL EL A++ EE+ ++ + Q+ H ++
Sbjct: 1250 ISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQ-----LEEKEN 1304
Query: 1786 ELKTQVEDLNENLLKLKEAL-KTSKNRENSLTDN---LNDLNNELQKKQKAYNKILREKE 1841
++K+ D+ E+L+ KEAL K N++ + ++ + L EL + A + E +
Sbjct: 1305 QIKSMKADI-ESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELK 1363
Query: 1842 EIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMK 1901
E E L +Q+ L LQ K++ I L+++ + + +L +V+++ K
Sbjct: 1364 EKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKV-- 1421
Query: 1902 EKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEK---- 1957
+ +KE++ E+ W K + K + + + K+L +L +K EK
Sbjct: 1422 DTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQI 1481
Query: 1958 LTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVED 2017
L+ +L D + G E E + +++K+ +LE ++ A R +ED
Sbjct: 1482 NLLKEELDQQNKRFDCLKG----EMEDDKSKMEKKESNLETELKSQTA-----RIMELED 1532
Query: 2018 LHLQNRYLQEKLHALEKQFS--KDTYSKPSISGIE-----SDDHCQREQELQKENLKLSS 2070
Q E L+ + K ++ KD K + ++ ++ R +E +++ L L +
Sbjct: 1533 HITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLEN 1592
Query: 2071 ENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKE-KAEVQRKLGHVRGSGRSGKTIPE 2129
+ +K +LE K+L + V+ +E + L+ ++E KL ++
Sbjct: 1593 QVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAE------- 1645
Query: 2130 LEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLS 2189
+K + K+++ +++ + EQ KK + SE +++ ++ EKLK+ Q
Sbjct: 1646 -QKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSE 1704
Query: 2190 MHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNL---EILNEKMTVQLEETGK 2246
++ E E + + EK+ + + NL E L +++ + EET
Sbjct: 1705 TLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVS 1764
Query: 2247 -----RLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKE------------LETDIAKK 2289
R Q+ E R +LE A++K + + + +L+E +E + K
Sbjct: 1765 SHFEMRCQYQE-RLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKN 1823
Query: 2290 N-QSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLAN 2348
N Q+ +L+ + + + Q+ + LEQ+IK E + L R+ +V R+
Sbjct: 1824 NIQAKQNLENVFDDVQKTLQEKELTCQILEQKIK---------ELDSCLVRQKEVHRVEM 1874
Query: 2349 HQLDK--EKAELIHQIEA-NKDQSGAESTIPDADQ-----------LKEKIKDLETQLKM 2394
+L EK + + Q++ NK E + + ++ + DLE +L
Sbjct: 1875 EELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAG 1934
Query: 2395 SDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGV 2454
++ EKQ L +EI +L+K+L +E+E LK Y +E EEK+K+ E L +
Sbjct: 1935 AEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQE------REEKIKQEQEDLEL 1988
Query: 2455 ELTS 2458
+ S
Sbjct: 1989 KHNS 1992
Score = 197 bits (502), Expect = 8e-50
Identities = 392/1887 (20%), Positives = 790/1887 (41%), Gaps = 317/1887 (16%)
Query: 707 QLTGRNEELRQELRES--RKEAINYSQQLAKANLKIDHLEK------ETSLLRQSEGSNV 758
++ R ++L E +E+ + K L++ +E + SL R S ++
Sbjct: 34 RMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVPSVESLFRSPIKESLFRSSSKESL 93
Query: 759 V-------FKGIDLPDGIAP-SSASIINSQNEYLIHLLQELENKE--KKLKNLEDSLEDY 808
V +DL A S ++S+ E L+ L ++ ++L+ +E SL Y
Sbjct: 94 VRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSY 153
Query: 809 NRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIK-VKEYNNLLNA 867
K++ + T + ++ EK+KL+ + Q K ++ L
Sbjct: 154 RGKYSEL------------------VTAYQMLQREKKKLQGILSQSQDKSLRRIAELREE 195
Query: 868 LQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAE 927
LQMD K + E + EK QY ++++ + L K+ + M +
Sbjct: 196 LQMDQQAKKHLQEEFDASL-----EEKD---QYISVLQTQVSLLKQRLRNG----PMNVD 243
Query: 928 VCEKIGCLQRFKEMAIFKI---AALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDN 984
V + + L+ E+ + + + VV++ S+ LE ++ + ++L++
Sbjct: 244 VLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVK----RQENLLKRCK 299
Query: 985 MLVQ-RTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKA 1043
+Q L E +L+EQ++ +ELE K+ LH E+ + T+L + ++ +
Sbjct: 300 ETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKD-LHMAEKT-KLITQLRDAKNLIEQ 357
Query: 1044 KKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETK--- 1100
+ + +V K M E E+ E + A+ LR+ +KQM + EL +
Sbjct: 358 LEQ--DKGMVIAETKRQMHETLEMKEEEIAQ--------LRSRIKQMTTQGEELREQKEK 407
Query: 1101 -----FAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKL 1155
F EL K AQK E+ R K ++ D Q I +EK E ++ + +
Sbjct: 408 SERAAFEELEKALSTAQKTEEARR--------KLKAEMDEQ-IKTIEKTSEEERISLQQ- 457
Query: 1156 REISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEA 1215
+++R + E+++ ++S ++++ L+ +L + + E+ L KL Q
Sbjct: 458 ----ELSRVKQEVVDVMKKSSEEQIAKLQ-KLHEKELARKEQELTKKLQTREREFQEQMK 512
Query: 1216 TALGKLESITSKL--QKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQ 1273
AL K +S K+ +K + +L LE+ +K+ L E N+ + L+Q ++ R +
Sbjct: 513 VALEKSQSEYLKISQEKEQQESLALEELELQKKAIL----TESENKLRDLQQEAETYRTR 568
Query: 1274 FSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQE---HRNMENKTLEMELKLKGLEE 1330
+++L++ K +QE KN ++ H E E+ + +E+
Sbjct: 569 ----------------ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVM-VEK 611
Query: 1331 LISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLE 1390
+ L+ K Q + W K++ L+ Q+ + E +++K E E+ +
Sbjct: 612 HKTELESLKHQQDAL-WTEKLQVLK-QQYQTEMEKLREK----------CEQEKETLLKD 659
Query: 1391 EEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLP 1450
+EI+ Q E + ++ +V + +L+ + +E+L A K EE + D + +
Sbjct: 660 KEIIFQAHIEEMNEKTLEKLDVK-QTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
Query: 1451 NQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLP 1510
+LE + + K + + + ++ +KE E +++ E+ + + IN+L L L
Sbjct: 719 QELEAKMDEQKNHHQ---------QQVDSIIKEHEVSIQRTEKALKDQ---INQLELLLK 766
Query: 1511 ATAEREKLIAELGRKEMEPKSHHTLKIAHQT-IANMQARLNQKEEVLKKYQRLLEKAREE 1569
ER+K + E HQ + N++A + + E L++ L+ +
Sbjct: 767 ---ERDKHLKE-----------------HQAHVENLEADIKRSEGELQQASAKLDVFQSY 806
Query: 1570 Q---REIVKKHEEDLHILHHRL-ELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE 1625
Q E K +EE L L +L +L+ + L L KQ +AE
Sbjct: 807 QSATHEQTKAYEEQLAQLQQKLLDLETERIL---------LTKQ-------------VAE 844
Query: 1626 MEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENI---KLQLQENHEDEVKK 1682
+E + L + ++++ + Q LE+Q E KVK + KL+ +++ K+
Sbjct: 845 VEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQ 904
Query: 1683 VKAEVEDLKYLLDQSQK-ESQCLKSELQAQKEAN---SRAPTTTMRNLVERLKSQLALKE 1738
+ E E++ + + QK E + L +L A++++ + T +N ++++ +
Sbjct: 905 ILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964
Query: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQI-------------VDRHTR 1785
+ Q+ L + LL+ A++ E + SQKE N + + V R
Sbjct: 965 EMQETLKKKLLDQEAKLKKELENTALEL-SQKEKQFNAKMLEMAQANSAGISDAVSRLET 1023
Query: 1786 ELKTQVEDLNE-NLLKLKEALKTSKNRENSLTDNLNDLNN-ELQKKQKAYNKILR----- 1838
K Q+E L E + +L + + + + N + L +++ +LQ+K++ ++ +
Sbjct: 1024 NQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLF 1083
Query: 1839 --EKEEIDQENDELKRQ-IKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV 1895
EKEE+++E LK + +K+ T+ + + K + + L + KL+ LE EV
Sbjct: 1084 GCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKL--EV 1141
Query: 1896 DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADK 1955
DL K+ KE E+ + + E + K+ E ++ T ++ +LK K++K
Sbjct: 1142 DLN----KSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNK 1197
Query: 1956 --EKLTLQRKLKTTGMTVDQVLGIRALES--EKELEELKKRNLDLENDILYMRAH----- 2006
E +L+ K + + + + + E+ E + EL + N IL +H
Sbjct: 1198 SLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRT 1257
Query: 2007 -----QALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYS----KPSISGIESDDHC-- 2055
L + V +L Q R L E+ + L F + T+ + I +++D
Sbjct: 1258 TKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLV 1317
Query: 2056 QREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLG 2115
++ LQKE E + + Q K+L N V +KE + K E + + ++L
Sbjct: 1318 TEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT 1377
Query: 2116 HVRGSGRSGKTIPELEKTIGLMKKVVEKVQREN----EQLKKASGILTSEKMANIEQENE 2171
+ ++ ++ E E I ++K ++ + E + L L+ EK++ +EQ ++
Sbjct: 1378 DLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDD 1437
Query: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNN-L 2230
S + K + +++ KEL+ + + K K+ +
Sbjct: 1438 ----------------WSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQI 1481
Query: 2231 EILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN 2290
+L E +L++ KR + E D KS E K LET++ +
Sbjct: 1482 NLLKE----ELDQQNKRFDCLKG-----EMEDDKS--------KMEKKESNLETELKSQT 1524
Query: 2291 QSITDLKQLVKEATEREQKVNKYNEDLEQQ--------IKILKHVPE-GAETEQGLKREL 2341
I +L+ + + T + +N+ ++ QQ ++ L+H E G E + +K
Sbjct: 1525 ARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAE 1584
Query: 2342 QVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQL------KMS 2395
+ + +Q+ KAEL E K + E +E++K LE +L K++
Sbjct: 1585 EKILTLENQVYSMKAEL----ETKKKE--LEHVNLSVKSKEEELKALEDRLESESAAKLA 1638
Query: 2396 DLEKQHLKEEIKKLKKEL--------ENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKK 2447
+L K+ +++I +KK+L E + + +L +E ++ +LEEK+K
Sbjct: 1639 EL-KRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS 1697
Query: 2448 LSEQLGVELTSPVAASE--EFEDEEES 2472
+ L P +A + ++EE+
Sbjct: 1698 VESSQSETLIVPRSAKNVAAYTEQEEA 1724
Score = 194 bits (493), Expect = 9e-49
Identities = 381/1780 (21%), Positives = 750/1780 (42%), Gaps = 312/1780 (17%)
Query: 23 ELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAK 82
EL +++ S+ ++ +L+ E + + + SL K + + + E+ K
Sbjct: 541 ELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600
Query: 83 FENQLKTKVMKLENELEMAQQSAGGRDTRFLR-------------NEICQLEKQLEQKDR 129
++ V K + ELE + T L+ E C+ EK+ KD+
Sbjct: 601 HNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDK 660
Query: 130 E------LEDM-EKELEK-EKKVNEQLALRNEEAE--NENSKLRRENKRLKKKNEQLCQD 179
E +E+M EK LEK + K E +L +E +E KL E LK + +++ Q+
Sbjct: 661 EIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQE 720
Query: 180 I---IDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNY---------ELIQYLDEIQT--- 224
+ +D QK Q+ + + E S R++ + K+ E ++L E Q
Sbjct: 721 LEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVE 780
Query: 225 ------------LTEANEKIEV------QNQEMRKNLEESVQEM-EKMTDEYNRMKAIVH 265
L +A+ K++V E K EE + ++ +K+ D +
Sbjct: 781 NLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTK 840
Query: 266 QTDNVIDQLK---KENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDD 322
Q V Q K E D +++QVQ+L L+ +N E + + ++ +V E KL +K+
Sbjct: 841 QVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSL-TQVYESKLEDGNKEQ 899
Query: 323 E-----IIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKE 377
E ++E + M+ +RE K + L Q + ++ I +L E+ E K
Sbjct: 900 EQTKQILVEKENMILQMRE--------GQKKEIEILTQKLSAKEDSIHILNEEYETKFKN 951
Query: 378 MEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREK 437
EK ++ E+Q L Q+ +K KE E TA + +K
Sbjct: 952 QEKKMEKVKQKAKEMQETLKKKLLDQEAKLK------------KELENTA----LELSQK 995
Query: 438 DKELVEALKRLKDYESGVYGLEDAVVEIK-NCKNQIKIRDREIEILTKEINKL----ELK 492
+K+ K L+ ++ G+ DAV ++ N K QI + E+ +E+N + E K
Sbjct: 996 EKQF--NAKMLEMAQANSAGISDAVSRLETNQKEQI---ESLTEVHRRELNDVISIWEKK 1050
Query: 493 ISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDL 552
++ +E + + E + L+ K ++ E + K + E + + KEI L+EE +
Sbjct: 1051 LNQQAEELQEIHE-IQLQEKEQ-EVAELKQ----KILLFGCEKEEMNKEITWLKEEGVKQ 1104
Query: 553 KKKIRQMAQERGKRSA-TSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEF 611
+ ++ ++ ++SA + L ++ L ++ KL++ +++++ +N F
Sbjct: 1105 DTTLNELQEQLKQKSAHVNSLAQDETKLKAHL--------EKLEV----DLNKSLKENTF 1152
Query: 612 LSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGE 671
L +L+E + E + +++ +KLK EE + L+
Sbjct: 1153 LQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKS---------------------- 1190
Query: 672 TSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQ 731
S E+ ++E K+ E S L Q+D + E L L E IN S
Sbjct: 1191 ------SHEKSNKSLEDKSLE-FKKLSEELAIQLDICCKKTEAL---LEAKTNELINISS 1240
Query: 732 QLAKANL-KIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQ- 789
A L +I H + T+ ++++ ++ K + + + + QN I Q
Sbjct: 1241 SKTNAILSRISHCQHRTTKVKEA----LLIKTCTVSE-LEAQLRQLTEEQNTLNISFQQA 1295
Query: 790 --ELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKL 847
+LE KE ++K+++ +E ++EKE + E ++ +
Sbjct: 1296 THQLEEKENQIKSMKADIE------------------SLVTEKEALQKEGGNQQQAASEK 1337
Query: 848 EDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELE 907
E + Q ++ E N + ++ + E K ++ S+++T L V ++ I +L E E
Sbjct: 1338 ESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSI----SLSEKE 1393
Query: 908 ---RQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELEL 964
LRK+ +++K ELL ++ K+ L + KI+AL++V D S SE +
Sbjct: 1394 AAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK------EKISALEQVDDWSNKFSEWK- 1446
Query: 965 ANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENIS-LKEQVESINKELEITKEKLHT 1023
K+ ++++ +++ + ++ S + + E I+ LKE+++ NK + K ++
Sbjct: 1447 --KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMED 1504
Query: 1024 IEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITM--LEMKELNE------------ 1069
+ E++ ES+++ KS T + I+ + IT +E++ LNE
Sbjct: 1505 DKSKMEKK-----ESNLETELKSQT-ARIMELEDHITQKTIEIESLNEVLKNYNQQKDIE 1558
Query: 1070 ----RQRAEHCQKMYEHLRTSLKQMEER-----------NFELETKFAELTKINLDAQKV 1114
Q+ +H Q++ E +K+ EE+ ELETK EL +NL +
Sbjct: 1559 HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSK 1618
Query: 1115 EQMLR---DELADSVSKAVSDADR---QRILELEK---NEMELKVEVSKLREISDIARRQ 1165
E+ L+ D L + +++ R Q+I ++K ++ME K E K S ++
Sbjct: 1619 EEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSE-- 1676
Query: 1166 VEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVS--LQLSEATALG---- 1219
LN + Q R++EV L +L ++ S ++LI NV+ + EA + G
Sbjct: 1677 ---LNTKLQEREREVHILEEKLKSVES-SQSETLIVPRSAKNVAAYTEQEEADSQGCVQK 1732
Query: 1220 ----KLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLR--QTIQSLRRQ 1273
K+ + L + E R+ Q+ +E + + R + + R L + Q +
Sbjct: 1733 TYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQS 1792
Query: 1274 FSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMEN------KTL-EMELKLK 1326
G L +EK K + + K + KN+ Q +N+EN KTL E EL +
Sbjct: 1793 MIGHLQEELEEKNKKYSLIVAQHVEK--EGGKNNIQAKQNLENVFDDVQKTLQEKELTCQ 1850
Query: 1327 GLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTI 1386
LE+ I L QK ++ + ++EL E ++ +++ N +
Sbjct: 1851 ILEQKIKELDSCLVRQK------EVHRVEMEELTSKYEKLQALQQMDGRN-------KPT 1897
Query: 1387 SSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPS 1446
LEE +++K H + + L + Q N++ E +
Sbjct: 1898 ELLEENTEEKSKSH-----------LVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEI 1946
Query: 1447 LPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELR 1506
+ L L + ++ ++ + I+ + + EEK+K+++ L L + L +++ E
Sbjct: 1947 VRLQKDLRMLRKEHQQELEIL--KKEYDQEREEKIKQEQEDLELKHNSTLK--QLMREFN 2002
Query: 1507 LRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKA 1566
+L A++E+ + E+ KE K+ ++ + + + Q NQ + + + L++
Sbjct: 2003 TQL---AQKEQEL-EMTIKETINKAQ---EVEAELLESHQEETNQLLKKIAEKDDDLKRT 2055
Query: 1567 REEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEM 1626
+ EI+ EE++ L+ Q + K++Q ++Q P N + + E+
Sbjct: 2056 AKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQK----LEQEENPGNDN---VTIMEL 2108
Query: 1627 EQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFE 1666
+ +A++ ++L+ K Q+ Q E ++K++E
Sbjct: 2109 QTQLAQK----TTLISDSKLKEQEFREQIHNLEDRLKKYE 2144
Score = 150 bits (379), Expect = 2e-35
Identities = 307/1466 (20%), Positives = 613/1466 (41%), Gaps = 212/1466 (14%)
Query: 16 DDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEK 75
+D +++E +L+ + + + +K+E I +TQ L K + + EE E
Sbjct: 893 EDGNKEQEQTKQILVEKENMILQMREGQKKEIEI----LTQKL-SAKEDSIHILNEEYET 947
Query: 76 AGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRN---EICQLEKQLEQKDREL- 131
+ Q K ++K K +++ L+ + + L N E+ Q EKQ K E+
Sbjct: 948 KFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMA 1007
Query: 132 -------EDMEKELEKEKKVNEQLALRNEEAENE-NSKLRRENKRLKKKNEQLCQDIIDY 183
D LE +K EQ+ E E N + K+L ++ E+L Q+I +
Sbjct: 1008 QANSAGISDAVSRLETNQK--EQIESLTEVHRRELNDVISIWEKKLNQQAEEL-QEIHEI 1064
Query: 184 QKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNL 243
Q Q Q E ++ + ++ E + EI L E K + E+++ L
Sbjct: 1065 QLQEKEQ---------EVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL 1115
Query: 244 EESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIM 303
++ + + + ++KA + + + +++ KEN Q Q+ E LK EED
Sbjct: 1116 KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVE----LKMLAEED---- 1167
Query: 304 VAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQ 363
KV E L + D+E + LK++ +KSN + ++++ +
Sbjct: 1168 ---KRKVSELTSKLKTTDEEF-----------QSLKSSH---EKSN-----KSLEDKSLE 1205
Query: 364 IKMLTEQVE-QYTKEMEKNTCIIEDLKNEL---QRNKGASTLSQQTHMKIQSTLDILKEK 419
K L+E++ Q +K ++E NEL +K + LS+ +H + ++T K
Sbjct: 1206 FKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTT------K 1259
Query: 420 TKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREI 479
KEA ++ + ++L E L + A +++ +NQIK +I
Sbjct: 1260 VKEALLIKTCTVSELEAQLRQLTEEQNTLN------ISFQQATHQLEEKENQIKSMKADI 1313
Query: 480 EILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILL 539
E L E L+ + ++ +A E+ + +L+E N+ L +++ + +
Sbjct: 1314 ESLVTEKEALQ---KEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKK---- 1366
Query: 540 KEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTE-DLNLTENISQGDRISERKLDLLS 598
EI SL ++ DL +++ K +A S L + D E + Q +S K+D LS
Sbjct: 1367 VEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLS-FKVDTLS 1425
Query: 599 LKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAI 658
+ +S + +++ S + E ++ ++++ + QN +KEL + + + E + I
Sbjct: 1426 KEKISALEQVDDW-SNKFSEWKK---KAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQI 1481
Query: 659 KEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQE 718
++++ D + + +E + +E K + +L+ ++ T R EL
Sbjct: 1482 NLLKEELDQQNKRFDCLKGEMEDDKSKMEKKES--------NLETELKSQTARIMELEDH 1533
Query: 719 LRESRKEAINYSQQLAKANLK--IDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASI 776
+ + E + ++ L N + I+H E L E G + + + + I
Sbjct: 1534 ITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQE------LGEEKDNRVKEAEEKI 1587
Query: 777 INSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTE 836
+ +N+ + + ELE K+K+L+++ S++ + + + L+E + K E
Sbjct: 1588 LTLENQ-VYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKR-KAE 1645
Query: 837 SKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSL 896
K I K++L Q+++ K ++Y + E+ L E R++ +L+ KS+
Sbjct: 1646 QK-IAAIKKQLLSQMEE---KEEQYK---KGTESHLSELNTKLQEREREVHILEEKLKSV 1698
Query: 897 IRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNS 956
+ + + R KN E E + GC+Q+ E KI+ LQ+ +
Sbjct: 1699 ESSQSETLIVPR-------SAKNVAAYTEQEEADSQGCVQKTYEE---KISVLQRNLTEK 1748
Query: 957 VSL-----SELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESIN 1011
L E E + E+ +Y++ L K LEH E + + + +
Sbjct: 1749 EKLLQRVGQEKEETVSSHFEMRCQYQERLIK----------LEHAEAKQHEDQSMIGHLQ 1798
Query: 1012 KELEITKEKLHTI-EQAWEQE-------TKLGNESSMDKAKKSITNSDIVS--ISKKITM 1061
+ELE +K I Q E+E K E+ D +K++ ++ + +KI
Sbjct: 1799 EELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKE 1858
Query: 1062 LE-----MKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQ 1116
L+ KE++ R E YE L+ +L+QM+ RN K EL + N + +
Sbjct: 1859 LDSCLVRQKEVH-RVEMEELTSKYEKLQ-ALQQMDGRN-----KPTELLEENTEEKSKSH 1911
Query: 1117 MLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSR 1176
+++ +L + +E + N++E K+ ++ RE + + V + + R
Sbjct: 1912 LVQPKLLSN-------------MEAQHNDLEFKLAGAE-REKQKLGKEIVRLQKDLRMLR 1957
Query: 1177 DKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKL--ESITSKLQKMEAY 1234
+ + L + +Y + +E K+ Q L+L + L +L E T QK +
Sbjct: 1958 KEHQQELEILKKEYDQEREE-----KIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQEL 2012
Query: 1235 NLRLEQ---KLDEKEQALYYARLEGRNR-AKHLRQTIQSLRR---QFSGALPLAQQEKFS 1287
+ +++ K E E L + E N+ K + + L+R ++ L ++E +
Sbjct: 2013 EMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTA 2072
Query: 1288 KTM-IQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVIN 1346
K +Q Q ++L+ + K Q+E+ +N T+ MEL+ + L + + + D+K ++
Sbjct: 2073 KVRDLQTQLEELQKKYQQKLEQEENPGNDNVTI-MELQTQ-LAQKTTLISDSKLKEQEFR 2130
Query: 1347 WHMKIEELRLQELKLN-------------------RELVKDKEEIKYLNNIISEY--ERT 1385
+ E RL++ + N L + E +YL ++ EY R
Sbjct: 2131 EQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTDVSLFGEPTEFEYLRKVLFEYMMGRE 2190
Query: 1386 ISSLEEEIVQQNKFHEERQMAWDQRE 1411
++ + I KF +++ +RE
Sbjct: 2191 TKTMAKVITTVLKFPDDQTQKILERE 2216
Score = 34.7 bits (78), Expect = 1.2
Identities = 68/360 (18%), Positives = 140/360 (38%), Gaps = 45/360 (12%)
Query: 2136 LMKKVVEKVQRENEQLKKA-SGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYES 2194
+ KK+ +K+ E +QL++A + S + + + + E+L ++ S +S
Sbjct: 1 MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQS 60
Query: 2195 KTKGTEKIIAENERLRKELKKET---DAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFA 2251
+ + + E L + KE+ ++++ + ++ E LN +
Sbjct: 61 FAQKLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDM 120
Query: 2252 ESRGPQLEGADSKSWKSIVVTRM---------YETKLKELETDIAKKNQSITDLKQLVKE 2302
+S L G K ++ R+ Y K EL T + L+ ++ +
Sbjct: 121 DSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQ 180
Query: 2303 ATERE-QKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVL------------RLANH 2349
+ ++ +++ + E+L+ + KH+ E E + L+ + Q + RL N
Sbjct: 181 SQDKSLRRIAELREELQMDQQAKKHLQE--EFDASLEEKDQYISVLQTQVSLLKQRLRNG 238
Query: 2350 QLDKEKAELIHQIEANKD--------QSGAESTIPDA------DQLKEKIKDLETQLKMS 2395
++ + + + Q+E + +S E + D + L++++K E LK
Sbjct: 239 PMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRC 298
Query: 2396 DLEKQHLKEEIKKLKKELENFDPSF---FEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452
Q KE+ L E E +E+E +K + E K I K L EQL
Sbjct: 299 KETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQL 358
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 228 bits (581), Expect = 6e-59
Identities = 490/2513 (19%), Positives = 1002/2513 (39%), Gaps = 430/2513 (17%)
Query: 18 LPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAG 77
L Q+++A+N S K L+ ++A
Sbjct: 25 LALQQQMAENQAASWRK-----------------------------------LKNSQEAQ 49
Query: 78 EEQAKFENQLKTKVMKLEN---ELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDM 134
+ QA +L+ KV++ + ELE ++ GG + N E L++ LE+
Sbjct: 50 QRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWEN---VEEPNLDELLVRLEEE 106
Query: 135 EKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETL 194
++ E +VN QL L E+A+ N LR + ++L +D+ + D
Sbjct: 107 QQRCESLAEVNTQLRLHMEKADVVNKALREDVEKL----------TVDWSRARDELMRKE 156
Query: 195 LSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMT 254
+ E ++ L ++ L+ E+ T EM+ + + E++
Sbjct: 157 SQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRR-------HFLEMKSATDRDLMELKAEH 209
Query: 255 DEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWK 314
+ V Q ++ N ++ +E LL + AK +E +
Sbjct: 210 VRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL------------LLLAKTQELE 257
Query: 315 LILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQY 374
+ E+I+ + + L+ A+L + + AL Q+++ + + + + +
Sbjct: 258 KEAHERSQELIQLKS-----QGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRET 312
Query: 375 TKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADA 434
+ +E N + + + L RN LS Q +K DI + +E + +A+
Sbjct: 313 VEILETNHTELMEHEASLSRNAQEEKLSLQQVIK-----DITQVMVEEGD---NIAQGSG 364
Query: 435 REKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKIS 494
E EL ++ DY+ L + + ++ +++ + +N L+ +
Sbjct: 365 HENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHD 424
Query: 495 DFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKK 554
+ +E +ALR+R + LT R++ + + E L KE E L++ R +L++
Sbjct: 425 QWEEEGKALRQR-------LQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQ 477
Query: 555 KIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSR 614
++ + QE + + +L L + +QG + + + E L
Sbjct: 478 QLEVLEQEAWRLRRVN----VELQLQGDSAQGQK-----------------EEQQEELHL 516
Query: 615 ELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSL 674
+ E+ER E + AK L EL+ + LE E + +++ Q +
Sbjct: 517 AVRERERLQEMLMGLEAKQSESLSELITLREALESSHLE-GELLRQEQTEVTAALARAEQ 575
Query: 675 IIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLA 734
I L N ++++ A+ L+A +L+ NE L + + +QQL
Sbjct: 576 SIAELSSSENTLKTEVAD--------LRAAAVKLSALNEAL-------ALDKVGLNQQLL 620
Query: 735 KANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENK 794
+ E+ S+ + E + + + A + +N +L LQ+ E
Sbjct: 621 QLE------EENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEA 674
Query: 795 ----EKKLKNLEDSLEDYNRKFAVIRHQQSL-------LYKEYLSEKETWK---TESKTI 840
+ L+++++ E+ +K + RHQQ L++E ++E E + +
Sbjct: 675 GAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL 734
Query: 841 KEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNE------- 893
EK LE ++Q ++ L L + ++ L E ++ +V++V +
Sbjct: 735 VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQI 794
Query: 894 ------KSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIG--CLQRFKEMAIFK 945
K +I+ ++LE + +Q+ + + + E+ G L++ K +
Sbjct: 795 QTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKE 854
Query: 946 IAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKE 1005
+ L++ + S + ELA L + R+ ++ + L ++ + +E ++ + +
Sbjct: 855 VNQLREKWEKERSWHQQELA----KALESLEREKMELEMRLKEQQTEMEAIQAQREEERT 910
Query: 1006 QVES--INKELEITKEKLHTIEQAWEQETKLGNES-SMDKAKKSITNSDIVSISKKITML 1062
Q ES +LE KE++ +E + + +L + S +++ ++ + + ++ T +
Sbjct: 911 QAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLK--EQETTGI 968
Query: 1063 EMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDEL 1122
+L E QR L+ + +Q + L+ + + L + +D QK ++
Sbjct: 969 LQTQLQEAQR---------ELKEAARQHRDDLAALQEESSSLLQDKMDLQK-------QV 1012
Query: 1123 ADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVES 1182
D S+ V+ D QR++E E E KLRE + R Q E+ + +E
Sbjct: 1013 EDLKSQLVAQDDSQRLVEQEVQE--------KLRETQEYNRIQKELEREKASLTLSLMEK 1064
Query: 1183 LRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKL 1242
+ L+ +A S + ++ L Q Q + ++E + ++++ EA L E +L
Sbjct: 1065 EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQL 1124
Query: 1243 DEK-------EQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQN 1295
E+ EQ L + +A L+ ++S Q A+Q+ ++ Q Q
Sbjct: 1125 LEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEAL--AAEQQPGNQAQAQAQL 1182
Query: 1296 DKL-KIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEEL 1354
L +Q+ S E R + + + GLE D GA+ + + L
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLE------PDQNGARSLFKRGPLLTAL 1236
Query: 1355 RLQEL-----KLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQ 1409
+ + KL+++L K ++ L + + + E ++ E E +++ H E Q
Sbjct: 1237 SAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAE---KSQVHTELQ----- 1288
Query: 1410 REVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIA------------- 1456
DL+RQL ++++ E + + L ++L A
Sbjct: 1289 ---DLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGEREL 1345
Query: 1457 LRKIKENI--------RIILETRATCKS---LEEKLKEKESALRLAEQNILSRDKVINEL 1505
L+ KEN+ ++E RA + LEE L+ SAL+L + + S
Sbjct: 1346 LQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESE------- 1398
Query: 1506 RLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEK 1565
R R A E+ +L G+ E L + QT+A + ++ E L+ + LEK
Sbjct: 1399 RERAQALQEQGELKVAQGKALQE-----NLALLTQTLAERE----EEVETLRGQIQELEK 1449
Query: 1566 AREEQREIVKKHEEDLHILHHRLELQAD--SSLNKFKQTAWDLMKQSPTPVPTNKHFIRL 1623
RE Q+ ++ DL + ++LQ + L K + L
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSV--------------------L 1489
Query: 1624 AEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKV 1683
+ V E++ L+ +++++ +D E QR + E ++ E E K Q+ E+ +V+ +
Sbjct: 1490 EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEK-KDQMIESQRGQVQDL 1548
Query: 1684 KAEVEDLKYL---LDQSQKESQC---LKSELQAQKEANSRAPTTTMRNLVERLK------ 1731
K ++ L+ L L+++ + +C L EL+ Q+E A T +L ER +
Sbjct: 1549 KKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQS 1608
Query: 1732 SQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHL----------------N 1775
SQ+ E L+R L E E+ + E+ I +++ HL
Sbjct: 1609 SQIHDLESHSTVLARELQERDQEVKSQREQ--IEELQRQKEHLTQDLERRDQELMLQKER 1666
Query: 1776 VQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLN--NELQKKQKAY 1833
+Q + D+ TR+ K EDL + L L+E + + + + + ++ Q+ +
Sbjct: 1667 IQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEH 1726
Query: 1834 NK-ILREKE---EIDQEN----DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE 1885
K ILR+KE E QE+ ELK Q+++ GL K L+ + ++++ L+
Sbjct: 1727 MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRK--VGETSLLLSQREQEIVVLQ 1784
Query: 1886 NQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNT 1945
QL+ E+ +LK + Q++++ + L +++ E+ L ++
Sbjct: 1785 QQLQEAREQGELKE----------------QSLQSQLDEAQRALAQRDQELEALQQEQQQ 1828
Query: 1946 LKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRA 2005
+ + ++ LQ L+ MT+ E EL++ K++ LE + L +
Sbjct: 1829 AQGQEERVKEKADALQGALEQAHMTLK--------ERHGELQDHKEQARRLEEE-LAVEG 1879
Query: 2006 HQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKEN 2065
+ + V+ DL ++R ++ L AL++Q ++ + D Q + L++ +
Sbjct: 1880 RRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERD 1939
Query: 2066 LKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGK 2125
+L E + + Q + ++ R + + + E L K A +Q K H+ +
Sbjct: 1940 QEL--EALRAESQSSRHQEEAARARAEA-----LQEALGKAHAALQGKEQHLLEQAELSR 1992
Query: 2126 TIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG 2185
+ LE + ++ ++ Q + QL++A I E I+ ++ + + ++++L+ L
Sbjct: 1993 S---LEASTATLQASLDACQAHSRQLEEALRIQEGE----IQDQDLRYQEDVQQLQQALA 2045
Query: 2186 HQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETG 2245
+ +E LR + ++E + K+ + + E M + + G
Sbjct: 2046 QR------------------DEELRHQQEREQ------LLEKSLAQRVQENMIQEKQNLG 2081
Query: 2246 KRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVK---- 2301
+ + E RG ++EL+ +A+K Q I +L++ +
Sbjct: 2082 QEREEEEIRG-------------------LHQSVRELQLTLAQKEQEILELRETQQRNNL 2122
Query: 2302 EATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQ 2361
EA K + EQ +K+ E L+REL+ L+ A Q E E+ +
Sbjct: 2123 EALPHSHKTSPME---EQSLKL-------DSLEPRLQRELERLQAALRQ--TEAREIEWR 2170
Query: 2362 IEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELE 2414
+A T L+E L+ + D E+Q L++E++ ++ LE
Sbjct: 2171 EKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE 2223
Score = 226 bits (575), Expect = 3e-58
Identities = 457/2317 (19%), Positives = 945/2317 (40%), Gaps = 352/2317 (15%)
Query: 8 KEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMK----- 62
+E++++ + EL D + + + ++ ++E E +I R T +++
Sbjct: 265 QELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELM 324
Query: 63 ---------AQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFL 113
AQE +L+L++V K + E + EN LE+ D +
Sbjct: 325 EHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDA 384
Query: 114 RNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKN 173
+ + L ++ + ++D+ ++L ++ L ++++ E E LR+ ++L +
Sbjct: 385 DKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGER 444
Query: 174 EQLCQDIIDYQKQIDS---QKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANE 230
+ L +D Q ++DS ++E L R E L ++ + L + E+Q +
Sbjct: 445 DTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQL---QGD 501
Query: 231 KIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKK--ENDHYQLQV--- 285
+ Q +E ++ L +V+E E++ + ++A ++ + + L++ E+ H + ++
Sbjct: 502 SAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQ 561
Query: 286 -------------QELTDLLKSKNEEDDPI---------MVAVNAKVEEWKLILSSKDDE 323
Q + +L S+N + + A+N + K+ L+ + +
Sbjct: 562 EQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQ 621
Query: 324 IIEYQQMLHNLREKLKNAQ--LDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKN 381
+ E Q + + E + A+ L D + ++ + E+++ ++ ++ E+ E++ +
Sbjct: 622 LEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQAD 681
Query: 382 TCIIEDLKNELQRN--------KGASTLSQQTHMKIQSTLDILKEKTKEAE-----RTAE 428
I++ K E+Q+ + A+T +Q H + + ++L +E E + A
Sbjct: 682 LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAAL 741
Query: 429 LAEADAREKDKE-LVEALKRLKD----YESGVYGLEDAVVEIKNCKNQIKIRDREI---- 479
A E+D++ L E L+ L ES ++ + I+ K Q++++ + +
Sbjct: 742 EVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801
Query: 480 EILTKEINKLELKISDFLDENEALRERVGL-------EPKTMIDLTEFRNSKHLKQQQYR 532
E++ E+ L+L++ + E R+ E KT ++ + + K + Q + +
Sbjct: 802 EVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREK 861
Query: 533 AEN------QILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQG 586
E Q L K +ESLE E+++L+ ++++ E A E+ E+
Sbjct: 862 WEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM---EAIQAQREEERTQAESALCQ 918
Query: 587 DRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENK- 645
++ K + L+ + + Q +EL + + LER R + K+++L E+
Sbjct: 919 MQLETEKERVSLLETLLQTQ-------KELADASQQLERLRQDM-----KVQKLKEQETT 966
Query: 646 -----QLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLH 700
QL+E +E+ +A ++ + D E+S ++ L +E D
Sbjct: 967 GILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVE--------DLKSQ 1018
Query: 701 LKAQVDQLTGRNEELRQELRESRK-EAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVV 759
L AQ D +E++++LRE+++ I + KA+L + +EKE LL E ++
Sbjct: 1019 LVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSI- 1077
Query: 760 FKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQ 819
+ + L L Q+++ + + K L +E
Sbjct: 1078 --------------------RQQELSALRQDMQEAQGEQKELSAQME------------- 1104
Query: 820 SLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKIL 879
L ++ + EKE D + Q+A ++E L A + +++ L
Sbjct: 1105 --LLRQEVKEKEA----------------DFLAQEAQLLEE----LEASHITEQQLRASL 1142
Query: 880 AENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFK 939
K LQ+ +S Q L E+Q +A++ LQ+
Sbjct: 1143 WAQEAKAAQLQLRLRSTESQLEALAA---------EQQPGNQAQAQAQLASLYSALQQAL 1193
Query: 940 EMAIFKIAALQKVVDNSVSLSELE--------------LANKQYNELTAKYRDILQKDNM 985
L D++ S+ LE L E A L +D
Sbjct: 1194 GSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLW 1253
Query: 986 LVQRTSNLEHLECENISLKEQVESINKEL---EITKEKLHT-IEQAWEQETKLGNESSMD 1041
Q+T ++ L++QV+ + + L E K ++HT ++ Q ++ E S
Sbjct: 1254 KTQQTRDV---------LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKW 1304
Query: 1042 KAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKF 1101
+ K++ S+++ + + M L R R Q+M L Q + N + +
Sbjct: 1305 EGKQNSLESELMELHET-----MASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEH 1359
Query: 1102 AELTKINLDAQKVEQMLRDELADSVSKAVS------DADRQRILELEKNEMELKVEVSKL 1155
+ + AQ + +E + A+ +++R+R L++ + ELKV K
Sbjct: 1360 LQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQE-QGELKVAQGKA 1418
Query: 1156 REISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEK-------SLIAKLHQHNV 1208
+ + +L R++EVE+LR Q+ + + Q + + SL K V
Sbjct: 1419 LQ------ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV 1472
Query: 1209 SLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQ 1268
LQ + L K S+ L + E+EQ L R + R K
Sbjct: 1473 DLQQEQIQELEKCRSVLE----------HLPMAVQEREQKLTVQREQIRELEKDRETQRN 1522
Query: 1269 SLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGL 1328
L Q L L ++++ MI+ Q ++ Q++K + + E K++
Sbjct: 1523 VLEHQL---LELEKKDQ----MIESQRGQV---QDLKKQLVTLECLALELEENHHKMECQ 1572
Query: 1329 EELISTLKDTKGAQKVINWHMKIE-ELRLQELKLNRELVKDKEEIK-YLNNIISEYERTI 1386
++LI L+ + Q+V H+ ++ E R QEL+ + D E L + E ++ +
Sbjct: 1573 QKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEV 1632
Query: 1387 SSLEEEI--VQQNKFHEERQMAWDQREVDLERQ-LDIFDRQ---QNEILNAAQKFEEATG 1440
S E+I +Q+ K H + + +E+ L+++ + + + Q Q +IL + E+
Sbjct: 1633 KSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILE--EDLEQIKL 1690
Query: 1441 SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK 1500
S+ + L Q ++ + +E R + + ++ L++KE + +++I +
Sbjct: 1691 SLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQE 1750
Query: 1501 VINELRLRLPAT-----------AEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARL 1549
+ ++L +L ++RE+ I L ++ E + LK ++Q++L
Sbjct: 1751 LKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ-----SLQSQL 1805
Query: 1550 NQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQ 1609
++ + L + + LE ++EQ++ + E R++ +AD+ +Q L ++
Sbjct: 1806 DEAQRALAQRDQELEALQQEQQQAQGQEE--------RVKEKADALQGALEQAHMTLKER 1857
Query: 1610 SPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIK 1669
+ RL E + +L +L L+ S++ E+ + + E
Sbjct: 1858 HGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAE----- 1912
Query: 1670 LQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVER 1729
Q QE HE E + ++ + +L + +E + L++E Q+ + A L E
Sbjct: 1913 -QAQE-HEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRH-QEEAARARAEALQEA 1969
Query: 1730 L-KSQLALKEKQQKALSRALLELRAEMTAAAEERIISA----TSQKEAHLNVQQ--IVDR 1782
L K+ AL+ K+Q L +A L E + A + + A + Q E L +Q+ I D+
Sbjct: 1970 LGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQ 2029
Query: 1783 HTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEE 1842
R + V+ L + L + E L+ + RE L +L Q+ +++EK+
Sbjct: 2030 DLR-YQEDVQQLQQALAQRDEELRHQQEREQLLEKSL---------AQRVQENMIQEKQN 2079
Query: 1843 IDQENDELKRQIKRLTSGLQGKPLT-DNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMK 1901
+ QE +E +I+ L ++ LT K+ I EL+ ++ N LE PM+
Sbjct: 2080 LGQEREE--EEIRGLHQSVRELQLTLAQKEQEILELRETQQR--NNLEALPHSHKTSPME 2135
Query: 1902 EKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQ 1961
E++ K + + + Q ++E ++ L++ E ++ L A+ +LQ
Sbjct: 2136 EQSLKLDSLE----PRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQ 2191
Query: 1962 RKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQ 2021
V L LE + E + L+ L+L L + L L
Sbjct: 2192 E--------VAMFLQASVLERDSEQQRLQDE-LELTRRAL---EKERLHSPGATSTAELG 2239
Query: 2022 NRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQK-------ENLKLSSENIE 2074
+R Q ++ ++PS G+E QR + LQ+ + +L N++
Sbjct: 2240 SRGEQ----GVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ 2295
Query: 2075 LKFQLEQANKDLPRLKNQVRDLKE--MCEFLKKEKAEVQRKLGHVRGSGRS-GKTIPELE 2131
L+ LEQ ++ +LK + + E K + ++ G RG S K + EL+
Sbjct: 2296 LRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDG--RGQKNSDAKCVAELQ 2353
Query: 2132 KTIGLMKK--VVEKVQRENEQLKKASGILTSEKMANI 2166
K + L++ +E+ Q+++ + A TS ++A +
Sbjct: 2354 KEVVLLQAQLTLERKQKQDYITRSAQ---TSRELAGL 2387
Score = 181 bits (459), Expect = 8e-45
Identities = 361/1730 (20%), Positives = 729/1730 (42%), Gaps = 240/1730 (13%)
Query: 767 DGIAPSSASIINSQNEYLIHLLQEL-ENKEKKLKNLEDSLEDYNRKFAVIRHQQS--LLY 823
+ + P S ++ E ++ L Q++ EN+ + L++S E R+ ++R Q+ L Y
Sbjct: 9 NNMKPQSLQLV--LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQY 66
Query: 824 KEYLSEKET------------WKT-ESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQM 870
+ + E E W+ E + E +LE++ QQ + E N L
Sbjct: 67 RSWCQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEE-QQRCESLAEVNTQLRLHME 125
Query: 871 DSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEK-QKNELLSMEAEVC 929
+D + K L E+ K+TV + + + + ++E++ K K + LLS+ EV
Sbjct: 126 KADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREV- 184
Query: 930 EKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQR 989
+ + F EM L ++ V LS L + A+ R+ M +
Sbjct: 185 --VTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGRE 242
Query: 990 TSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITN 1049
+ L L + L+++ ++EL +L ++ ++KA+
Sbjct: 243 PAQLLLLLAKTQELEKEAHERSQEL-----------------IQLKSQGDLEKAE----- 280
Query: 1050 SDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINL 1109
+ ++T L +++ E +KM + LR +++ +E + EL A L++
Sbjct: 281 -----LQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSR--- 332
Query: 1110 DAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEIL 1169
+AQ+ + L+ + D V + D +N +EL + + D A + + ++
Sbjct: 333 NAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQD-ADKALTLV 391
Query: 1170 NAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQ 1229
+ R + V+ LR QL Q + L Q + + +L+ +T +
Sbjct: 392 RSVLTRRRQAVQDLRQQLAGCQ------EAVNLLQQQHDQWEEEGKALRQRLQKLTGERD 445
Query: 1230 KMEAYNLRLEQKLD---EKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKF 1286
+ + L+ ++D ++ + L AR E R + + L Q LRR
Sbjct: 446 TLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRV------------- 492
Query: 1287 SKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLE-MELKLKGLE----ELISTLKDTKGA 1341
+QLQ D Q K QQE ++ + E ++ L GLE E +S L + A
Sbjct: 493 -NVELQLQGDSA---QGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREA 548
Query: 1342 QKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHE 1401
+ + H++ E LR ++ ++ L + ++ I L++ + + ++ L V+ + +E
Sbjct: 549 LE--SSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNE 606
Query: 1402 ERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIP----------DPSLPLPN 1451
+A D+ V L +QL + + + + + E+A ++ +
Sbjct: 607 A--LALDK--VGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNT 662
Query: 1452 QLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINEL-RLRLP 1510
LE L+K +E E +A + ++E EKE + ++ ++ +L +L
Sbjct: 663 HLEAQLQKAEE---AGAELQADLRDIQE---EKEEIQKKLSESRHQQEAATTQLEQLHQE 716
Query: 1511 ATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQ 1570
A + E L + KE + L++ Q + + L ++ + L + LLE + E
Sbjct: 717 AKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEA 776
Query: 1571 REIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRL---AEME 1627
++ + + +LE+Q + + Q+ + ++L E
Sbjct: 777 QQ----QNSVIEVTKGQLEVQIQT------------VTQAKEVIQGEVRCLKLELDTERS 820
Query: 1628 QTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEV 1687
Q E+D + L ++ LE+Q+ E +V + + + H+ E+ K +
Sbjct: 821 QAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESL 880
Query: 1688 EDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALK-EKQQKALSR 1746
E K L+ KE Q +QAQ+E R E Q+ L+ EK++ +L
Sbjct: 881 EREKMELEMRLKEQQTEMEAIQAQREEE--------RTQAESALCQMQLETEKERVSLLE 932
Query: 1747 ALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRE-LKTQVEDLNENLLKLKEAL 1805
LL+ + E+ A+++ + + VQ++ ++ T L+TQ+++ +LKEA
Sbjct: 933 TLLQTQKELADASQQ-----LERLRQDMKVQKLKEQETTGILQTQLQEAQR---ELKEAA 984
Query: 1806 KTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKP 1865
+ + ++L Q+ + +L++K ++ ++ ++LK Q+
Sbjct: 985 RQHR--------------DDLAALQEESSSLLQDKMDLQKQVEDLKSQL----------V 1020
Query: 1866 LTDNKQSLIE-ELQRKVK------KLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKW 1918
D+ Q L+E E+Q K++ +++ +LE + + L M+++ + L+ E
Sbjct: 1021 AQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKE--QRLLVLQEADSIR 1078
Query: 1919 QAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLT----LQRKLKTTGMTVDQV 1974
Q ++ +R ++E +GE L+ Q+ L+ + + + L L +L+ + +T +Q
Sbjct: 1079 QQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHIT-EQQ 1137
Query: 1975 LGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRY--LQEKLHAL 2032
L E + +L+ R E+ + + A Q P + L + Y LQ+ L ++
Sbjct: 1138 LRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQ-PGNQAQAQAQLASLYSALQQALGSV 1196
Query: 2033 ---EKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIE-LKFQLEQANKDLPR 2088
+ S S PS+ G+E D + R L K L++ + E + L + ++DL +
Sbjct: 1197 CESRPELSGGGDSAPSVWGLEPDQNGAR--SLFKRGPLLTALSAEAVASALHKLHQDLWK 1254
Query: 2089 -------LKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVV 2141
L++QV+ L+E + EK++V +L ++ + + E K G +
Sbjct: 1255 TQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQ--RQLSQNQEEKSKWEGKQNSLE 1312
Query: 2142 EKVQRENEQLKKASGILTSEKMANIEQENEK--LKAELEKLKAHLGHQLSMHYESKTKGT 2199
++ +E + L ++ +E + E+ L+A E L A + H + E++ + +
Sbjct: 1313 SELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQAS 1372
Query: 2200 EKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLE 2259
I E E LR A++ L++ NE ++E +R Q + +G +L+
Sbjct: 1373 AAGILE---------------EDLRTARSALKLKNE----EVESERERAQALQEQG-ELK 1412
Query: 2260 GADSKSWKS--IVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATE--------REQK 2309
A K+ + ++T+ + +E+ET + + Q + +++ K A E R Q+
Sbjct: 1413 VAQGKALQENLALLTQTLAEREEEVET-LRGQIQELEKQREMQKAALELLSLDLKKRNQE 1471
Query: 2310 VNKYNE---DLEQQIKILKHVPEGA-ETEQGLKRELQVLRLANHQLDKEKAELIHQ-IEA 2364
V+ E +LE+ +L+H+P E EQ L + + +R + ++ L HQ +E
Sbjct: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Query: 2365 NKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELE 2414
K ES LK+++ LE L + E H E +KL KELE
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLVTLEC-LALELEENHHKMECQQKLIKELE 1580
Score = 171 bits (434), Expect = 6e-42
Identities = 401/1953 (20%), Positives = 797/1953 (40%), Gaps = 319/1953 (16%)
Query: 27 NLLISLSKVEVNE-LKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFEN 85
N ++L KV +N+ L ++EN R+ + A +V+LA E EK E
Sbjct: 605 NEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLA--EAEKRREA------ 656
Query: 86 QLKTKVMKLENELEMAQQSAGG--RDTRFLRNEICQLEKQLEQKDRELEDMEKELEK--- 140
L K LE +L+ A+++ D R ++ E +++K+L + + E +LE+
Sbjct: 657 -LWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ 715
Query: 141 EKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQID---SQKETLLSR 197
E K E++ R A E L RE L+ + + + +D D +Q+ S KE L S
Sbjct: 716 EAKRQEEVLAR---AVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESS 772
Query: 198 RGEDSDYRS--QLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTD 255
E S +++K E+ +IQT+T+A E I+ + + ++ L+ + E+ D
Sbjct: 773 LFEAQQQNSVIEVTKGQLEV-----QIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERD 827
Query: 256 EYNRMKAIVHQT------------DNVIDQLK----KENDHYQLQVQELTDLLKSKNEED 299
R A Q + ++QL+ KE +Q QEL L+S E
Sbjct: 828 AAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQ---QELAKALESLEREK 884
Query: 300 DPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMAL------ 353
+ + + + E + I + +++E + + L + QL+ +K V L
Sbjct: 885 MELEMRLKEQQTEMEAIQAQREEERTQAESALCQM-------QLETEKERVSLLETLLQT 937
Query: 354 QQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRN---------------KGA 398
Q+ + + Q++ L + ++ + ++ T I++ E QR +
Sbjct: 938 QKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEE 997
Query: 399 STLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGL 458
S+ Q M +Q ++ LK + + + L E + +EK +E E + K+ E L
Sbjct: 998 SSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASL 1057
Query: 459 EDAVVEIKN----CKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTM 514
+++E + + IR +E+ L +++ + + + + + E LR+ V +
Sbjct: 1058 TLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADF 1117
Query: 515 I----DLTEFRNSKHLKQQQYRA----------ENQILLKEIESLEEERLDLKKKIRQMA 560
+ L E + H+ +QQ RA + Q+ L+ ES + E L +++ A
Sbjct: 1118 LAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTES-QLEALAAEQQPGNQA 1176
Query: 561 QERGKRSATSGLTTEDLNLT--------------------ENISQGDRISERKLDLLSLK 600
Q + + ++ + L E G R ++ LL+
Sbjct: 1177 QAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTAL 1236
Query: 601 NMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKE 660
+ S L ++L + ++ + R + K + +L + E Q+ ++++ + + +
Sbjct: 1237 SAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ 1296
Query: 661 MQKDPDV-KGGETSL---------IIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTG 710
Q++ +G + SL + SL+ + E + E + L L+A + LT
Sbjct: 1297 NQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGEREL-LQAAKENLTA 1355
Query: 711 RNEELRQELRESRKEA-----INYSQQLAKANLKIDHLEKETSLLR----QSEGSNVVFK 761
+ E L+ + E+R +A + + A++ LK+ + E E+ R Q +G V +
Sbjct: 1356 QVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQ 1415
Query: 762 GIDLPDGIAPSSASIINSQNEY--LIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQ 819
G L + +A + ++ + E L +QELE + + K + L +K R+Q+
Sbjct: 1416 GKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKK----RNQE 1471
Query: 820 SLLYKEYLSEKETWKTESK----TIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEM 875
L +E + E E ++ + ++E ++KL Q +Q K+ N L+ E+
Sbjct: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLEL 1531
Query: 876 KKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCL 935
+K + I + + L +Q TL L +L + + K + C++
Sbjct: 1532 EK----KDQMIESQRGQVQDLKKQLVTLECLALELEENHHKME----------CQQKLIK 1577
Query: 936 QRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNEL----TAKYRDILQKDNMLVQRTS 991
+ + ++A +D EL+ + Q ++L T R++ ++D + +
Sbjct: 1578 ELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE 1637
Query: 992 NLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSD 1051
+E L+ + L + +E ++EL + KE++ +E ++TK+ E +++ K S+
Sbjct: 1638 QIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKI-LEEDLEQIKLSLRERG 1696
Query: 1052 IVSISKKITMLEMKELNERQRAEHCQK-MYEHLRTSLKQMEERNFELETKFAELTKINLD 1110
+++ M E E E + Q+ EH++ L+ E+ E+E + + ++
Sbjct: 1697 RELTTQRQLMQERAE--EGKGPSKAQRGSLEHMKLILRDKEK---EVECQQEHIHELQEL 1751
Query: 1111 AQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILN 1170
++EQ L+ + + V + L L + E E+ V +L+E AR Q E+
Sbjct: 1752 KDQLEQQLQ-----GLHRKVGETS----LLLSQREQEIVVLQQQLQE----AREQGELKE 1798
Query: 1171 AQQQS-----------RDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALG 1219
QS RD+E+E+L+ + QAQ E+ + K +L+ + T
Sbjct: 1799 QSLQSQLDEAQRALAQRDQELEALQQE--QQQAQGQEERVKEKADALQGALEQAHMT--- 1853
Query: 1220 KLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALP 1279
L+ +LQ + RLE++L +EGR R + L + + LR
Sbjct: 1854 -LKERHGELQDHKEQARRLEEEL----------AVEGR-RVQALEEVLGDLR-------- 1893
Query: 1280 LAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTK 1339
A+ + K ++ LQ + ++ + + E R +++ L+ + LK ++
Sbjct: 1894 -AESREQEKALLALQQ---QCAEQAQEHEVETRALQDSWLQAQAVLKERDQ--------- 1940
Query: 1340 GAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKF 1399
++E LR + + + + L + + + E+ +++Q
Sbjct: 1941 ----------ELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQ--- 1987
Query: 1400 HEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLP---NQLEIA 1456
E + + L+ LD + L A + +E G I D L QL+ A
Sbjct: 1988 -AELSRSLEASTATLQASLDACQAHSRQ-LEEALRIQE--GEIQDQDLRYQEDVQQLQQA 2043
Query: 1457 LRKIKENIR------IILETRATCKSLEEKLKEKES-ALRLAEQNILSRDKVINELRLRL 1509
L + E +R +LE + E ++EK++ E+ I + + EL+L L
Sbjct: 2044 LAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTL 2103
Query: 1510 PATAEREKLIAEL------GRKEMEPKSHHTLKIAHQTIA--NMQARLNQKEEVLKKYQR 1561
A++E+ I EL E P SH T + Q++ +++ RL ++ E L+ R
Sbjct: 2104 ---AQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALR 2160
Query: 1562 LLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFI 1621
E E RE K + L + Q +S++ ++ A L
Sbjct: 2161 QTEAREIEWRE--KAQDLALSL------AQTKASVSSLQEVAMFL--------------- 2197
Query: 1622 RLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQR-------EITELKVKEFENIKLQLQE 1674
+ +V E+D L +L+ + LE++R EL + + ++L
Sbjct: 2198 -----QASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQL---- 2248
Query: 1675 NHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQL 1734
EV V+AE D +K+S + E Q A + ++ +L+S L
Sbjct: 2249 ---GEVSGVEAEPSP-----DGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTL 2300
Query: 1735 ALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVD-RHTRELKTQVED 1793
E++++ L R +RA + E +A+S + Q+ D + EL+ +V
Sbjct: 2301 EQVERERRKLKRE--AMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVL 2358
Query: 1794 LNENLLKLKEALKTSKNRENSLTDNLNDLNNEL 1826
L L ++ + R + L L++ L
Sbjct: 2359 LQAQLTLERKQKQDYITRSAQTSRELAGLHHSL 2391
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 224 bits (571), Expect = 8e-58
Identities = 496/2495 (19%), Positives = 1007/2495 (40%), Gaps = 446/2495 (17%)
Query: 113 LRNEICQLEKQLEQKDRELEDM---------------EKELEKEKKVNEQLALRNEEAEN 157
+ +E+ + ++E+ +RELE+M E +++ + QL ++A
Sbjct: 160 MESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARR 219
Query: 158 ENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQ 217
E + RE L +++++L Q Q ETL + S S +L+Q
Sbjct: 220 EKDETMREFLELTEQSQKL-----QIQFQQLQASETLRN---------STHSSTAADLLQ 265
Query: 218 YLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKE 277
+I T + E+ + ++ +K E+ ++ + + ++K + D ++ KE
Sbjct: 266 AKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQE---KIKVYEMEQDKKVENSNKE 322
Query: 278 NDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREK 337
++QE +++ N + ++ K E K L++ D + E Q+ + ++
Sbjct: 323 ------EIQEKETIIEELNTK----IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQE 372
Query: 338 LKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKN----TCIIEDLKNELQ 393
+KN +L+ S +Q ++ +IK L VE+ K K+ T I++ ++ E Q
Sbjct: 373 IKNMKLELTNS-----KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQ 427
Query: 394 RNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYES 453
R K ++ M Q + + +E + + A++ E R K +
Sbjct: 428 R-KLEQLRAELDEMYGQQIVQMKQELIR--QHMAQMEEMKTRHKGE-------------- 470
Query: 454 GVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKT 513
+E+A+ N I + + +I+++ IN+L +K+ D + E L+E +GL
Sbjct: 471 ----MENALRSYSN----ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL---- 518
Query: 514 MIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLT 573
K Q+Q + L E ++ R + ++ ++ + S L
Sbjct: 519 ------ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLK 572
Query: 574 TEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRT-VIAK 632
E ++ +E+ + + E ++ +K + KN L R +E +LER RT ++
Sbjct: 573 AEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFS 632
Query: 633 FQNKLKELVEE--------------------NKQLEEGMKEILQAIKEMQKDPD---VKG 669
+ +L +L E+ +Q++ E+ Q I+ MQ + D K
Sbjct: 633 HEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQ 692
Query: 670 GETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINY 729
+ L I L+ L ++ + +E + Q+++L E LRQE KE
Sbjct: 693 NQLILEISKLKDLQQSLVNSKSE-------EMTLQINELQKEIEILRQE----EKEKGTL 741
Query: 730 SQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQ 789
Q++ + LK + LEK+ +++ E DL + A
Sbjct: 742 EQEVQELQLKTELLEKQ---MKEKEN--------DLQEKFA------------------- 771
Query: 790 ELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEK---ETWKTESKTIKEEKRK 846
+LE + LK+ + +LED + + ++ L++ + + K W+ E + + EE
Sbjct: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 847 LEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVEL 906
L+ Q Q ++++ N + + + +VN + L +Y L+++
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFAEKN-----------------FEVNYQELQEEYACLLKV 874
Query: 907 ERQLRKENEKQKNELLSMEAEVCEKIGCLQR------------FKEMAIFKIAALQ--KV 952
+ L KQ+ E S + E++ LQR F E F L+ +V
Sbjct: 875 KDDLEDSKNKQELEYKSKLKALNEELH-LQRINPTTVKMKSSVFDEDKTFVAETLEMGEV 933
Query: 953 V--DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESI 1010
V D + + +LE+ ++ EL+ + D+ ++ L Q+ + L E SLK++ E +
Sbjct: 934 VEKDTTELMEKLEVTKREKLELSQRLSDLSEQ---LKQKHGEISFLNEEVKSLKQEKEQV 990
Query: 1011 N---KELE--ITKEKLHTIEQAWEQETKL----------GNESSMDKAKKSITNSDIVSI 1055
+ +ELE I + ++ Q + L G E S+ K KS + +
Sbjct: 991 SLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMV 1050
Query: 1056 SKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVE 1115
K++ E + E + E Q + +HL + K+ R T+ +E K
Sbjct: 1051 EDKVS-FENMTVGEESKQE--QLILDHLPSVTKESSLR----ATQPSENDK--------- 1094
Query: 1116 QMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQS 1175
L+ EL +L+ E+N++ L++E ++ + ++ +
Sbjct: 1095 --LQKEL--------------NVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENE 1138
Query: 1176 RDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA---------LGKLESITS 1226
+DK + SL+ +L+ AQ ++ + K+HQ + ++ T +GKL+ S
Sbjct: 1139 KDKALCSLKEELI--FAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVS 1196
Query: 1227 K-----LQKM-----EAYN--LRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQF 1274
+ LQ + E Y L+ E ++KE + Y + R +Q +
Sbjct: 1197 EECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENM 1256
Query: 1275 SGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELIST 1334
L +E ++K ++ LQ KI + + + EN E E + + ++
Sbjct: 1257 HTLLNKVTEE-YNKLLV-LQTRLSKIWGQQTDGMKLEFGEENLPKE-ETEFLSIHSQMTN 1313
Query: 1335 LKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIV 1394
L+D +N K+ L +D E+ K L + E E ISSL++++
Sbjct: 1314 LEDID-----VNHKSKLSSL------------QDLEKTK-LEEQVQELESLISSLQQQLK 1355
Query: 1395 QQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQL- 1453
+ + +E EI ++ + + S PSLP+ + +
Sbjct: 1356 ETEQNYEA------------------------EIHCLQKRLQAVSESTVPPSLPVDSVVI 1391
Query: 1454 -EIALRK-------IKENIRIILETRATCKSLEE----KLKEKESALRLAEQNILSRDKV 1501
E ++ +K+NI +E EE KL EK+ +L E+ KV
Sbjct: 1392 TESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVA----KV 1447
Query: 1502 INELRLRLPATAEREKLIAELGRKE--MEPKSHHTLKIAHQTIANMQARLNQKEEVLKKY 1559
I + + A A++ +L G KE K H + Q N + +L+Q + + +
Sbjct: 1448 IVSMSI---AFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFN-EMKLSQDQIGFQTF 1503
Query: 1560 QRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKH 1619
+ + K +EE + + K+ E H + L ++S + ++ ++ S +K
Sbjct: 1504 ETVDVKFKEEFKPLSKELGE-----HGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKT 1558
Query: 1620 FI--RLAEMEQTVAEQDDSLSSLL--VKLKKVSQDLERQREITELKVKEFENIKLQLQEN 1675
FI + E +V+ D S +L +L+ + Q+L RQ + + + ++ E
Sbjct: 1559 FIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER 1618
Query: 1676 HEDEVKKVKAEVEDL-KYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQL 1734
++ ++++ E++ L + L +S +++ L SE + R L+E L+
Sbjct: 1619 QREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERE--------------RVLLEELE--- 1661
Query: 1735 ALKEKQQKALSRALLELRAEMTAAAE------ERIISATSQKEAHLNVQQIVDRHTRELK 1788
ALK+ + ELR T E +KE + + +
Sbjct: 1662 ALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNER 1721
Query: 1789 TQVEDLNENLLK-LKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQE- 1846
++ N LLK L E +KT+ E ++ ++ + + K Q + + I R + E +
Sbjct: 1722 YALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKS 1781
Query: 1847 --NDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQL-EGKVEEVDLKPMKEK 1903
++E R G + N ++ ++ + +L +L ++ P E+
Sbjct: 1782 CVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEE 1841
Query: 1904 NAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEV-FTLTKQLNTLKDLFAKADK--EKLTL 1960
+ + QA +E + + E ++ Q +++ F + + E L
Sbjct: 1842 ------LMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKC 1895
Query: 1961 QRKLK---------TTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPR 2011
Q +L+ + V+ ++ + + L +R + + DI+ + L
Sbjct: 1896 QEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
Query: 2012 DSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSE 2071
+ +++L + + +QE+ L +Q + EQ+L +E KL E
Sbjct: 1956 SNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV-----------EQQLLQETEKLMKE 2004
Query: 2072 NIELKFQLEQANKDLPR-LKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPEL 2130
+E++ Q E+ DL + +K D++E + + E +L +R ++ L
Sbjct: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA------L 2058
Query: 2131 EKTIGLMKKVVEK--VQRENEQLKKASGILTSEKMANI----EQENEKLKAELEKLKAHL 2184
EK + M+K +++ + RE+E+ I E+ + + +E E+E+L HL
Sbjct: 2059 EKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 2118
Query: 2185 GHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLE--ILNEKMTVQLE 2242
+ KT +++ E+L++++++ + EKL LE +L T Q
Sbjct: 2119 --------KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKV 2170
Query: 2243 ETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKE 2302
E K E++ P+L E +L+ I +K + IT+L++ +++
Sbjct: 2171 EDRKHFGAVEAK-PELS---------------LEVQLQAERDAIDRKEKEITNLEEQLEQ 2214
Query: 2303 ATEREQKVNKYNEDLEQQIKILK-----HVPEGAETEQGLKRELQVLRLANHQLDKEKAE 2357
E + N+ + L Q++I K + E + + K +++ L LA + D +
Sbjct: 2215 FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQ 2274
Query: 2358 LIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFD 2417
H + Q E + + DQL E++ L+ QLK++ K + EE +L ++LE
Sbjct: 2275 DQHVLFGKFAQIIQEKEV-EIDQLNEQVTKLQQQLKITTDNK--VIEEKNELIRDLETQI 2331
Query: 2418 PSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452
+ E +K N +EE+++ L E ++KL ++L
Sbjct: 2332 ECLMSDQECVKRNREEEIEQ---LNEVIEKLQQEL 2363
Score = 221 bits (562), Expect = 9e-57
Identities = 497/2624 (18%), Positives = 1113/2624 (42%), Gaps = 359/2624 (13%)
Query: 20 RQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEE 79
++E+ + K++V E++ +K+ ++ K + QE E +EE+ E
Sbjct: 290 KKEDFTMQISFLQEKIKVYEMEQDKK---------VENSNKEEIQEKETIIEELNTKIIE 340
Query: 80 QAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKEL- 138
+ K K ++L+++L A + G +L++Q+ QK++E+++M+ EL
Sbjct: 341 EEK-------KTLELKDKLTTADKLLG------------ELQEQIVQKNQEIKNMKLELT 381
Query: 139 ---EKEKKVNE---QLALRNEEAENENSK--------LRRENKRLKKKNEQLCQDIID-Y 183
+KE++ +E QL EE + N K ++R + ++K EQL ++ + Y
Sbjct: 382 NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441
Query: 184 QKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQN---QEMR 240
+QI K+ L+ R + ++ E+ L +T ++I++ N E+
Sbjct: 442 GQQIVQMKQELI--RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN 499
Query: 241 KNLEESVQEMEKMTDEYNRMK----AIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKN 296
L+++ + EK+ +E + A+ Q ++++++L + Q Q + + N
Sbjct: 500 IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559
Query: 297 EEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQG 356
E + + K E ++ +S+ + +E + K+K L+ +K+ V+
Sbjct: 560 EAHKSLSTVEDLKAE---IVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 616
Query: 357 IQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDIL 416
QE + + ++ T+ + + +E+ K + EDL E++ L + + +D L
Sbjct: 617 SQEAELE-RLRTQLLFSHEEELSK---LKEDL--EIEHRINIEKLKDNLGIHYKQQIDGL 670
Query: 417 KEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGL--EDAVVEIKNCKNQIKI 474
+ + + T + + + K +L+ + +LKD + + E+ ++I + +I+I
Sbjct: 671 QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
Query: 475 RDRE-----------------IEILTKEI----NKLELKISDFLDENEALRERVGLEPKT 513
+E E+L K++ N L+ K + EN L++ E KT
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD----EKKT 786
Query: 514 MIDLTEFRNSKHLKQQ-------QYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKR 566
+ D+ + +++ + ++++ + KEIE L EE DLK++ Q+ +E K+
Sbjct: 787 LEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQ 846
Query: 567 SATSGLTTE--DLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLE 624
T + ++N E + + + K DL KN E + K++ + + +E L+
Sbjct: 847 RNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL---KALNEELHLQ 903
Query: 625 RSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVN 684
R K ++ + +E+K + E L+ + ++KD T+ ++ LE
Sbjct: 904 RINPTTVKMKSSV---FDEDKTF---VAETLEMGEVVEKD-------TTELMEKLE---- 946
Query: 685 AIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLE 744
+ + + L Q+ Q G L +E++ ++E S + + + I+H
Sbjct: 947 -VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
Query: 745 KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDS 804
E ++ S+++ + + A S S +N ++ E + + + E+S
Sbjct: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
Query: 805 LEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNL 864
++ ++ H S+ + L + T +E+ +++E L+ + ++++
Sbjct: 1066 KQEQ----LILDHLPSVTKESSL--RATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC 1119
Query: 865 LNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSM 924
L+ + + + EN + + + E+ + Q + EL++ + E + K +
Sbjct: 1120 LSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGD 1179
Query: 925 EAEVCEK-IGCLQR-FKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQK 982
E + IG LQ+ E + + L V+ + + N + E + Y +
Sbjct: 1180 EGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENED 1239
Query: 983 DNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQET-----KLGNE 1037
+ R + E + L + E NK L + + + W Q+T + G E
Sbjct: 1240 PELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTR----LSKIWGQQTDGMKLEFGEE 1295
Query: 1038 SSMDKAKK------SITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQM- 1090
+ + + +TN + + ++ K + +++L + + E Q++ E L +SL+Q
Sbjct: 1296 NLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL-ESLISSLQQQL 1354
Query: 1091 --EERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRIL---ELEKNE 1145
E+N+E AE+ + Q V + S ++++D QR + K
Sbjct: 1355 KETEQNYE-----AEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKN 1409
Query: 1146 MELKVEVSK---LREISDIARRQVEILNAQQQSR-DKEVESLRMQLLDYQAQSDEKSLIA 1201
++ +E S ++E ++I V++L Q Q + ++EV + + + AQ E S I+
Sbjct: 1410 IDGTIEFSGEFGVKEETNI----VKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465
Query: 1202 KLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAK 1261
++ S + + A + + + + +D K + + + + +
Sbjct: 1466 GGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEF--KPLSKELGE 1523
Query: 1262 HLRQTIQSLRR-----QFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMEN 1316
H ++ + S + + +E FSK DK I+++ + + +M+
Sbjct: 1524 HGKEILLSNSDPHDIPESKDCVLTISEEMFSK-------DKTFIVRQSIHDEISVSSMDA 1576
Query: 1317 KTLEM--ELKLKGL-EELISTLKDTKGAQKVINW-HMKI--------EELRLQELKLNRE 1364
M E +L+ + +EL+ ++ + A +++ HM+ E+L+ + +LNR+
Sbjct: 1577 SRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQ 1636
Query: 1365 LVKDKEEIKYLNNIISEYERTISSLEE-EIVQQNKFHEERQMAWDQREVDLERQLDIFDR 1423
L + N++SE ER + LEE E ++Q ++ + R + Q +
Sbjct: 1637 LAQRSSIDN--ENLVSERERVL--LEELEALKQLSLAGREKLCCELRNSSTQTQNG--NE 1690
Query: 1424 QQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENI-RIILETRATCKSLEEKLK 1482
Q E+ K +E D + + AL+K + +I+LE T ++EE +
Sbjct: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750
Query: 1483 EKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPK--SHHTLKIAHQ 1540
L + +++ S+ L R A A + + E + + S+ +
Sbjct: 1751 RH--VLGILDRSSKSQSSA--SLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRN 1806
Query: 1541 TIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFK 1600
I NM +++ EE + QRL+ ++ EI ++EE + + RL+ + L
Sbjct: 1807 DI-NMWSKVT--EEGTELSQRLV-RSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS 1862
Query: 1601 QTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVK--LKKVSQDLERQREIT 1658
+T+ L T M ++ ++ ++ SL + L++ + R RE
Sbjct: 1863 ETSSQLEHAKVTQTEL---------MRESFRQKQEATESLKCQEELRERLHEESRAREQL 1913
Query: 1659 ELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRA 1718
+++ + E + + + DE + ++++ ++D+ ++E C + LQ
Sbjct: 1914 AVELSKAEGVI----DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ--------- 1960
Query: 1719 PTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ 1778
L+++ +++++ LSR ++AE ++ + + L VQ
Sbjct: 1961 ----------ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC 2010
Query: 1779 IVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILR 1838
++ +L+ QV+ L ++ + + +N+ +L N L+K+ + K L
Sbjct: 2011 QAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLD 2070
Query: 1839 EKE-EIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV-D 1896
E+ + + E D +++I++L L+ P Q + E R+V++L N L+ K ++ +
Sbjct: 2071 EQAIDREHERDVFQQEIQKLEQQLKVVP---RFQPISEHQTREVEQLANHLKEKTDKCSE 2127
Query: 1897 LKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKE 1956
L KE+ ++ R EE +K + ++ + L + F +++ K A K
Sbjct: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVS-ADTF---QKVEDRKHFGAVEAKP 2183
Query: 1957 KLTLQRKLKTTGMTVDQV-LGIRALESEKEL--EELKKRNLDLENDILYMRAH-QALPRD 2012
+L+L+ +L+ +D+ I LE + E EEL+ +N +++ L+M+ Q
Sbjct: 2184 ELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQ--LHMQLEIQKKEST 2241
Query: 2013 SVVEDLHLQNRYLQEKLH----ALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKL 2068
+ +++L +N+ ++ + A+++ + T + + G + ++E E+ + N ++
Sbjct: 2242 TRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV 2301
Query: 2069 SSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIP 2128
+ +LK + NK + +RDL+ E L ++ V+R
Sbjct: 2302 TKLQQQLKITTD--NKVIEEKNELIRDLETQIECLMSDQECVKRNR-------------- 2345
Query: 2129 ELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQL 2188
E+ I + +V+EK+Q+E + G TS ++ +E + LK +L+ + + +L
Sbjct: 2346 --EEEIEQLNEVIEKLQQELANI----GQKTSMNAHSLSEEADSLKHQLDVV---IAEKL 2396
Query: 2189 SMHYESKTKGTEKIIAEN---------ERLRKEL---KKETDAAEKLR-IAKNNLEIL-- 2233
++ + +T E +N +L +EL K+E ++ EK++ I +N++ +
Sbjct: 2397 ALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAID 2456
Query: 2234 ---NEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN 2290
+K +++ T L+ E++ + + SI+ ET+L +LE+ ++ K+
Sbjct: 2457 HLSKDKPELEVVLTEDALKSLENQ-TYFKSFEENGKGSII---NLETRLLQLESTVSAKD 2512
Query: 2291 QSITDLKQLVKEATER--------EQKVNKYNEDLEQQIKI-------LKHVPEGAE--- 2332
+T + +K+ E+ ++K+ + +E+++ L+ V E A+
Sbjct: 2513 LELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQ 2572
Query: 2333 --------------------TEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAE 2372
E L ++ L L +L+ + E+ + K+Q
Sbjct: 2573 DNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQ---- 2628
Query: 2373 STIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELE-----------NFDPSFF 2421
I + + L+++ K LE Q + EK+ ++E K+ +++E N + FF
Sbjct: 2629 VEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFF 2688
Query: 2422 EEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEE 2465
E+E L+ + +EK +KL E+L V+ T+ + ++
Sbjct: 2689 NELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKD 2732
Score = 179 bits (454), Expect = 3e-44
Identities = 388/1983 (19%), Positives = 836/1983 (42%), Gaps = 254/1983 (12%)
Query: 19 PRQEELADNLLISLSKV--EVNELKSEKQENVIHLFRITQSLM-------KMKAQEVELA 69
P EEL N+ L ++ E SE + H ++TQ+ + K +A E
Sbjct: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHA-KVTQTELMRESFRQKQEATESLKC 1895
Query: 70 LEEVEKAGEEQAKFENQLKTKVMKLENELE--MAQQSAGGRDTRFLRNEICQLEKQLEQK 127
EE+ + E+++ QL ++ K E ++ +++ R + + I +LE++L
Sbjct: 1896 QEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
Query: 128 DRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQI 187
L+++E E ++ ++ E L+ + E + E + ++ L ++ E+L ++ ++ Q Q
Sbjct: 1956 SNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ---LLQETEKLMKEKLEVQCQA 2012
Query: 188 DSQKETLLSR-RGEDSDYRSQLSKKNYELIQYLD-EIQTLTEANEKIEVQNQEMRKNLEE 245
+ ++ L + + + D Q+S+ EL Q + E+ L + N+ +E Q ++MRK L+E
Sbjct: 2013 EKVRDDLQKQVKALEIDVEEQVSRF-IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
Query: 246 SVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVA 305
+ E D + + + Q V+ + + ++H +V++L + LK K ++ ++++
Sbjct: 2072 QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS 2131
Query: 306 V----------NAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDAD-----KSNV 350
N ++E+ + + + ++ + ++ ++A + +
Sbjct: 2132 KEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQL 2191
Query: 351 MALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQ 410
A + I ++ +I L EQ+EQ+ +E+E KNE QQ HM+++
Sbjct: 2192 QAERDAIDRKEKEITNLEEQLEQFREELEN--------KNE---------EVQQLHMQLE 2234
Query: 411 STLDILKEKTKEAERTAELAEADAREKD--KELVEALKRLKDYESGVYGLEDAVVEIKNC 468
+K + R EL + + KD ++L A+K ES +D V
Sbjct: 2235 I------QKKESTTRLQELEQENKLFKDDMEKLGLAIK-----ESDAMSTQDQHVLFGKF 2283
Query: 469 KNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQ 528
I+ ++ EI+ L +++ KL+ ++ +N+ + E+ L + + + +
Sbjct: 2284 AQIIQEKEVEIDQLNEQVTKLQQQLK-ITTDNKVIEEKNELIRDLETQIECLMSDQECVK 2342
Query: 529 QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588
+ E + L + IE L++E ++ +K A + A S D+ + E ++ +
Sbjct: 2343 RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE-EADSLKHQLDVVIAEKLALEQQ 2401
Query: 589 ISERKLDLLSLKN-MSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQL 647
+ ++ +KN + E K L++EL +R+ E + + +N + ++ +
Sbjct: 2402 VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD 2461
Query: 648 EEGMKEIL--QAIKEMQKDPDVK----GGETSLI-----IPSLERLVNA----------- 685
+ ++ +L A+K ++ K G+ S+I + LE V+A
Sbjct: 2462 KPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQ 2521
Query: 686 IESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL-RESRKEAINYSQQLAKANLKIDHLE 744
I+ +G F+ + K V+ E++ L + + EA+ + + N I
Sbjct: 2522 IKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEP 2581
Query: 745 KETSL-----LRQSE-GSNV---VFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKE 795
+ T++ LR+ E GS++ + +L + S+I + + I LE KE
Sbjct: 2582 ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLE-KE 2640
Query: 796 KKLKNLEDSLEDYNRK------------FAVIRHQQSLLYKE----YLSEKETWKTESKT 839
KKL L+ LE +K V++ L + + +E E + ES
Sbjct: 2641 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2700
Query: 840 IKEEKRKLEDQVQ--QDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
K E +++ + Q+ + VKE N + +LQ D +++ LAE K+++L+ +++ +
Sbjct: 2701 TKAELASYKEKAEKLQEELLVKETN--MTSLQKDLSQVRDHLAEAKEKLSILEKEDETEV 2758
Query: 898 RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSV 957
++ E K ++ ++ + + KI + ++ + K A +Q + +
Sbjct: 2759 QESKKACMFEPLPIKLSKS-----IASQTDGTLKISSSNQTPQILV-KNAGIQINLQSEC 2812
Query: 958 SLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEIT 1017
S E+ Q+ E K +++ + + +E +IS E E
Sbjct: 2813 SSEEVTEIISQFTEKIEKMQEL---------HAAEILDMESRHIS----------ETETL 2853
Query: 1018 KEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQ 1077
K + + Q ++E G ++ + +S S I ++ + + ++ Q
Sbjct: 2854 KREHYVAVQLLKEE--CGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQ 2911
Query: 1078 KMY-EHLRTSLKQMEERNFELET---KFAELTKINLDAQKVEQMLRDELADSVSKAVSDA 1133
+Y H + E R E E+ F + K L A E M L +S D
Sbjct: 2912 GIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDH 2971
Query: 1134 DRQRILE--LEKNEMELKVEVSKLREISDI-----ARRQVEILNAQQQSRDKEVESLRMQ 1186
Q++ E LE E K ++ + + D+ +R+ E+ ++ Q +
Sbjct: 2972 SIQQVSEPWLE----ERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL 3027
Query: 1187 LLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKE 1246
L Q +E+S++ + +E TALG +++ LEQ++ E +
Sbjct: 3028 LALQQVFLEERSVLLAAFR-------TELTALGTTDAV--------GLLNCLEQRIQE-Q 3071
Query: 1247 QALYYARLEGRNRA--KHLRQTIQSLRRQFSG-ALPLAQQEKFSKTMIQLQNDKLKIMQ- 1302
Y A +E +A + L IQ+L Q +G + L ++++ K +L ++ Q
Sbjct: 3072 GVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS 3131
Query: 1303 EMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKV-INWHMKIEELRLQELKL 1361
+M Q E +M+++ E++ +L + +++ LK K+ + +K + L+EL+
Sbjct: 3132 QMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEA 3191
Query: 1362 NRELVKDK-EEIKYLNNIISEYERTIS----SLEEEIVQQNKFHEERQMAWDQREVDLER 1416
R VKDK +E+ LN+ ++ ++ +LE+E + + E + + + LE
Sbjct: 3192 FRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLES 3251
Query: 1417 ------QLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILET 1470
QL++ QQ ++LN +Q+ E+ + D L + L+ + E+ ++ +
Sbjct: 3252 QKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3311
Query: 1471 RATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPK 1530
++ E +L + L + R LP+ E L+ EL +K++E K
Sbjct: 3312 MSSTLDRERELHAQ-----------LQSSDGTGQSRPPLPS----EDLLKEL-QKQLEEK 3355
Query: 1531 SHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLE- 1589
+++ ++T L +++ ++K +++ K + ++E + ++ +H L ++E
Sbjct: 3356 HSRIVELLNETEKYKLDSLQTRQQ-MEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVED 3414
Query: 1590 LQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQ 1649
LQ + + DL Q + + E ++ E+++ S + + +++
Sbjct: 3415 LQRQLEEKRQQVYKLDLEGQRLQGI--------MQEFQKQELEREEKRESRRILYQNLNE 3466
Query: 1650 DLERQREITELKVKEF---ENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKS 1706
+T + + + + I+ + +E++ ++ ++ + L+ +++ QC+ S
Sbjct: 3467 --PTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVAS 3524
Query: 1707 ELQAQKEANSRAPTTTMRNLVERLKSQLALKEK---QQKALSRALLELRAEMTAAAEERI 1763
+LQ + S ERL+ + A E Q+ + +L+L+ EE
Sbjct: 3525 KLQVLPQKAS-----------ERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPS 3573
Query: 1764 I-----SATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALK----TSKNRENS 1814
+ S S E L + H +L + DL ++KL+E ++ T R+NS
Sbjct: 3574 LVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNS 3633
Query: 1815 LTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLI 1874
+LN N I EKE ++E L++ +KR + + SL+
Sbjct: 3634 SRFSLNGGAN-------IEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLL 3686
Query: 1875 EEL 1877
+ L
Sbjct: 3687 QTL 3689
Score = 176 bits (447), Expect = 2e-43
Identities = 460/2455 (18%), Positives = 1011/2455 (41%), Gaps = 350/2455 (14%)
Query: 27 NLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQ------EVELALEEVEKAGEEQ 80
N+ I+ +++ + S+K++ L I + ++ Q E+ + E++++A +
Sbjct: 492 NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTI 551
Query: 81 AKFENQLK------TKVMKLENELEMAQQSAGGRDTRF---LRNEICQLEKQLEQKDREL 131
A+ E++L + V L+ E+ A +S + + + N +LE ++K+ L
Sbjct: 552 AEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611
Query: 132 EDMEKELEKE-KKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDI--IDYQKQID 188
+ M + E E +++ QL +EE E SKL+ + + + N + +D I Y++QID
Sbjct: 612 DRMAESQEAELERLRTQLLFSHEE---ELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
Query: 189 S--------------QKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTL--TEANEKI 232
+K+ L++++ + S+L L+ E TL E ++I
Sbjct: 669 GLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI 728
Query: 233 EVQNQEMRKN--LEESVQEMEKMTDEYNR-MKAIVHQTDNVIDQLKKENDHYQLQVQELT 289
E+ QE ++ LE+ VQE++ T+ + MK + QL+ EN + + + L
Sbjct: 729 EILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE 788
Query: 290 DLLKS----KNEEDDPIMVAVNAKVEE--WKL---ILSSKDDEIIEYQQMLHNLREKLKN 340
D+LK EE + ++ +K ++ W+ IL +++++ + L+ EK +N
Sbjct: 789 DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRN 848
Query: 341 AQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRN----- 395
A+K+ + Q+ +E +K+ + + K+ + ++ L EL
Sbjct: 849 TFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908
Query: 396 --KGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREK---DKELVEALKRLKD 450
K S++ + + TL++ + K+ E E REK + L + ++LK
Sbjct: 909 TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ 968
Query: 451 YESGVYGLEDAVVEIKNCKNQIKIRDREIEIL-----TKEINKLELKISDFLDENEALRE 505
+ L + V +K K Q+ +R RE+EI+ + + + ++S LD +
Sbjct: 969 KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTS 1028
Query: 506 RVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGK 565
R + ++ + SK + + + EN + +E + E+ LD + + + R
Sbjct: 1029 RGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQ-EQLILDHLPSVTKESSLRAT 1087
Query: 566 RSATSGLTTEDLNLTENISQGDRIS-ERKLDLLSLKNMSEAQSKNEF-----------LS 613
+ + + ++LN+ ++ R+ E + LSL + E+ L
Sbjct: 1088 QPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147
Query: 614 RELI----EKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKE-----MQKD 664
ELI EK ++L++ + + K +E +E K L + ++ +A+ E +Q
Sbjct: 1148 EELIFAQEEKIKELQKIHQLELQTM-KTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTL 1206
Query: 665 PDVKGGETSLIIPSLERLVNAIESKNAEGIF----DASLH-LKAQVDQLTGRNEELRQEL 719
V G P+L+ VNA + +N+ D L + +V L ++
Sbjct: 1207 CSVLG---EYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKV 1263
Query: 720 RESRKEAINYSQQLAKA------NLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSS 773
E + + +L+K +K++ E E ++E ++ + +L D
Sbjct: 1264 TEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE-ENLPKEETEFLSIHSQMTNLEDIDVNHK 1322
Query: 774 ASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRH--QQSLLYKEYLSEKE 831
+ + + Q+ L ++++ E + +L+ L++ + + H Q+ L +
Sbjct: 1323 SKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPP 1382
Query: 832 TWKTESKTIKEE------------KRKLEDQVQ-QDAIKVKEYNNLLNALQMD-----SD 873
+ +S I E K+ ++ ++ VKE N++ L+ +
Sbjct: 1383 SLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEE 1442
Query: 874 EMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIG 933
E+ K++ S I Q E S I +Q +++++ M+ ++IG
Sbjct: 1443 EVAKVIV--SMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQ-DQIG 1499
Query: 934 CLQRFKEMAI-FKIAALQKVVDNSVSLSELELANKQYNELTAKY-------RDILQKDNM 985
Q F+ + + FK + E+ L+N +++ ++ KD
Sbjct: 1500 -FQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKT 1558
Query: 986 LVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKK 1045
+ R S + + ++ Q+ ++LE +++L Q +Q T+L ++ M + ++
Sbjct: 1559 FIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER 1618
Query: 1046 SITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE------------- 1092
D + ++I L ++L +R ++ + E R L+++E
Sbjct: 1619 Q--REDQEQLQEEIKRLN-RQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLC 1675
Query: 1093 ---RNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELK 1149
RN +T+ + ++ Q ++ D + V + +R + + +++
Sbjct: 1676 CELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKIL 1735
Query: 1150 VEVSKLREISD--IARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHN 1207
+EV K + I R + IL+ +S +S + +A++ KS + + H
Sbjct: 1736 LEVVKTTAAVEETIGRHVLGILDRSSKS-----QSSASLIWRSEAEASVKSCVHEEHTRV 1790
Query: 1208 VSLQLSEATALGKLESITSKLQKMEAYNLRLEQKL-----------DEKEQALYYARLEG 1256
+ + + + K+ L Q+L E E+ +
Sbjct: 1791 TDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRL 1850
Query: 1257 RNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQN--DKLKIMQEMKNSQQEHRNM 1314
+ + L + I Q A + Q E ++ Q Q + LK +E++ E
Sbjct: 1851 QAAVEKLLEAISETSSQLEHA-KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRA 1909
Query: 1315 ENKTLEMELKLKGLEELISTLKDTKGA----------------QKVINWHMKIEELRLQE 1358
++ ++L E +I D K Q+++ +++EL ++
Sbjct: 1910 RE---QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQ 1966
Query: 1359 LKLNRE---LVKDKEEIK-----YLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQR 1410
++ E L + KE +K ++ E E+ + E Q K ++ Q
Sbjct: 1967 QQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKAL 2026
Query: 1411 EVDLERQLDIFD-------------RQQNEILNAAQKFEEATGSIPDPSLPLPNQLEI-- 1455
E+D+E Q+ F RQQN+ L ++ E+ + + ++ ++ ++
Sbjct: 2027 EIDVEEQVSRFIELEQEKNTELMDLRQQNQALE--KQLEKMRKFLDEQAIDREHERDVFQ 2084
Query: 1456 -ALRKIKENIRII-----------LETRATCKSLEEKLKEKESALRLAEQ---NILSRDK 1500
++K+++ ++++ E L+EK + L EQ +I R++
Sbjct: 2085 QEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNE 2144
Query: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
I +L R+ E+ L++ +++E + H A ++ ++ +L + + + + +
Sbjct: 2145 EIEKLEFRV-RELEQALLVSADTFQKVEDRKHFGAVEAKPELS-LEVQLQAERDAIDRKE 2202
Query: 1561 RL---LEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTN 1617
+ LE+ E+ RE ++ E++ LH +LE+Q S + ++ + N
Sbjct: 2203 KEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE-----------N 2251
Query: 1618 KHFIRLAEMEQTVAEQDDSLSS-----LLVKLKKVSQDLERQREITELKVKEFENIKLQL 1672
K F E ++ D++S+ L K ++ Q E++ EI +L ++ ++ QL
Sbjct: 2252 KLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ--EKEVEIDQLN-EQVTKLQQQL 2308
Query: 1673 QENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKS 1732
+ +++V +E+ L+ + + +CL S+ + K RN
Sbjct: 2309 KITTDNKV------IEEKNELIRDLETQIECLMSDQECVK-----------RN------- 2344
Query: 1733 QLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRE---LKT 1789
+E++ + L+ + +L+ E+ ++ ++A S E +++ +D E L+
Sbjct: 2345 ----REEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQ 2400
Query: 1790 QVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAY----NKILREKEEIDQ 1845
QVE NE + +K LK + + N LT L L E + +K N + + + +
Sbjct: 2401 QVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSK 2460
Query: 1846 ENDEL-----KRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPM 1900
+ EL + +K L + K +N + I L+ ++ +LE+ + K E+
Sbjct: 2461 DKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYK 2520
Query: 1901 KEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTL 1960
+ K+ +E+ E + Q KI ++ ++EK QL +++ +AK ++ T+
Sbjct: 2521 QIKDMQEQ--GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQE-YAKFCQDNQTI 2577
Query: 1961 QRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSV-VEDLH 2019
+ + T + + +R E ++ L R +LE+ ++ M L ++ V + + +
Sbjct: 2578 SSEPERT--NIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKN 2635
Query: 2020 LQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQK-----ENLKLSSE--- 2071
+ + ++KL L+K +E ++ QRE+E ++ E LK ++E
Sbjct: 2636 VLEK--EKKLLELQKL-------------LEGNEKKQREKEKKRSPQDVEVLKTTTELFH 2680
Query: 2072 -NIELKF--QLEQANKDLPRLKNQVRDLKEMCEFLKKE-------KAEVQRKLGHVRGSG 2121
N E F +LE + K ++ KE E L++E +Q+ L VR
Sbjct: 2681 SNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDH- 2739
Query: 2122 RSGKTIPELEKTIGLMKKVVEKVQRENEQ--LKKASGILTSEKMANIEQENEKLKAELEK 2179
+ E ++ + +++K E +E+++ + + I S+ +A+ K+ + +
Sbjct: 2740 -----LAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQT 2794
Query: 2180 ---LKAHLGHQLSMHYESKTKGTEKIIAE-NERLRKELKKETDAAEKLRIAKNNL 2230
L + G Q+++ E ++ +II++ E++ K +E AAE L + ++
Sbjct: 2795 PQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEK--MQELHAAEILDMESRHI 2847
Score = 176 bits (447), Expect = 2e-43
Identities = 519/2690 (19%), Positives = 1099/2690 (40%), Gaps = 448/2690 (16%)
Query: 9 EIMKVDPDDLPRQEELADNLLISLSK--VEVNELKSEKQENVIHLFRITQSLMKMKAQEV 66
E+++ D +L + E+ + LS+ +++E +K + L +SL K + ++V
Sbjct: 932 EVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSL-KQEKEQV 990
Query: 67 ELALEEVEKA-GEEQAKFENQLKTKVMKL-ENELEMAQQSAGGRDTRFLRNEICQLEKQL 124
L E+E +A+ T+V L + + M + A G ++ N+ E ++
Sbjct: 991 SLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKV--NKSFGEESKI 1048
Query: 125 EQKDR-ELEDME--KELEKEKKVNEQLALRNEEAE------NENSKLRRE---------N 166
+D+ E+M +E ++E+ + + L +E+ +EN KL++E +
Sbjct: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQND 1108
Query: 167 KRLKKKNEQLCQDII------DYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLD 220
RL+ + +++C ++ ++ ++++K+ L E+ + + K + I L
Sbjct: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL- 1167
Query: 221 EIQTLT-----EANEKIEVQNQEMRKNLEES----VQEMEKMTDEYNR--MKAIVHQTD- 268
E+QT+ + + + + +++K + E +Q + + EY +K V+ D
Sbjct: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227
Query: 269 -NVIDQLKKEND----HYQLQVQELTD----LLKSKNEEDDPIMVAVNA----------- 308
N D + + D Y+ +VQ+ + LL EE + ++V
Sbjct: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDG 1287
Query: 309 -KVEEWKLILSSKDDEIIEYQQMLHNLRE-------KLKNAQLDADKSNVMALQQGIQER 360
K+E + L ++ E + + NL + KL + Q D +K+ L++ +QE
Sbjct: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQ-DLEKTK---LEEQVQEL 1343
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT 420
+S I L +Q+++ + E I L+ LQ +S+ T + +D +
Sbjct: 1344 ESLISSLQQQLKETEQNYEAE---IHCLQKRLQ------AVSEST-VPPSLPVDSVVITE 1393
Query: 421 KEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIE 480
+A+RT + D + SG +G+++ +K + Q + E
Sbjct: 1394 SDAQRTMYPGSCVKKNIDGTIEF---------SGEFGVKEETNIVKLLEKQYQ------E 1438
Query: 481 ILTKEINKLELKIS-DFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILL 539
L +E+ K+ + +S F + E R G E + + + + QQ+ N++ L
Sbjct: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGGKE-----NTASSKQAHAVCQQEQHYFNEMKL 1493
Query: 540 KE----IESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLN-LTENISQGDRISERKL 594
+ ++ E + K++ + +++E G+ L+ D + + E+ ISE
Sbjct: 1494 SQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMF 1553
Query: 595 DLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEI 654
K QS ++ +S ++ R L + + + +L +E++Q E +++
Sbjct: 1554 S--KDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQA 1611
Query: 655 LQAIKEMQKDPDVKGGETSLIIPSLERLV---NAIESKNA----EGIFDASLHLKAQVDQ 707
E Q++ + E I L R + ++I+++N E + L Q+
Sbjct: 1612 HMRQMERQREDQEQLQEE---IKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS- 1667
Query: 708 LTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPD 767
L GR E+L ELR S + N ++ + + KE L R+ E D+P
Sbjct: 1668 LAGR-EKLCCELRNSSTQTQNGNENQGEVE---EQTFKEKELDRKPE---------DVPP 1714
Query: 768 GIAPSSASIINSQNEYLIHLLQELENKEKKLKN---------LEDSLEDYNRKFAVIRHQ 818
I + + N L+ +L E+ ++ L+ S + + + R +
Sbjct: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774
Query: 819 QSLLYKEYLSEKETWKTESKT------------------IKEEKRKLEDQVQQDAIKVKE 860
K + E+ T T+ + EE +L ++ + E
Sbjct: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE 1834
Query: 861 YN--------NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRK 912
+ N+ + LQ +++ + ++E S ++ +V + L+R+ R+
Sbjct: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRE---------SFRQ 1885
Query: 913 ENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNEL 972
+ E E L + E+ E++ R +E +++ + V+D E L +Q E
Sbjct: 1886 KQEA--TESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD--EKTLFERQIQEK 1941
Query: 973 TAKYRDILQK-DNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQE 1031
T DI+ + + L+ ++ L+ LE E ++E+ E ++++ E K + +EQ QE
Sbjct: 1942 T----DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE 1997
Query: 1032 T-KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQM 1090
T KL E + + D+ K++ LE ++ ++ ++ + T L +
Sbjct: 1998 TEKLMKEKLEVQCQAEKVRDDL---QKQVKALE---IDVEEQVSRFIELEQEKNTELMDL 2051
Query: 1091 EERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKV 1150
++N LE + ++ K LD Q ++ R+ D + E++K E +LKV
Sbjct: 2052 RQQNQALEKQLEKMRKF-LDEQAID---REHERDVFQQ-----------EIQKLEQQLKV 2096
Query: 1151 EVSKLREISDIARRQVE----------------ILNAQQQSRDKEVESLRMQLLDYQAQS 1194
V + + IS+ R+VE +L+ +Q RD + + ++ L+++ +
Sbjct: 2097 -VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
Query: 1195 DEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARL 1254
E++L+ ++ + G +E+ K E L LE +L + A+
Sbjct: 2156 LEQALLVSADTFQ---KVEDRKHFGAVEA------KPE---LSLEVQLQAERDAIDRKEK 2203
Query: 1255 EGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNM 1314
E N + L Q + L + E+ + +QL+ K + ++ +QE++
Sbjct: 2204 EITNLEEQLEQFREELENK---------NEEVQQLHMQLEIQKKESTTRLQELEQENKLF 2254
Query: 1315 ENKTLEMELKLKGLEELISTLKDT---KGAQKVINWHMKIEELRLQELKLNREL--VKDK 1369
++ ++ L +K + + + + K AQ + ++I++L Q KL ++L D
Sbjct: 2255 KDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDN 2314
Query: 1370 EEIKYLNNIISEYERTISSL--EEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNE 1427
+ I+ N +I + E I L ++E V++N RE ++E+ ++ ++ Q E
Sbjct: 2315 KVIEEKNELIRDLETQIECLMSDQECVKRN------------REEEIEQLNEVIEKLQQE 2362
Query: 1428 ILNAAQKFEEATGSIPDPSLPLPNQLEIALRK---IKENIR-----------IILETRAT 1473
+ N QK S+ + + L +QL++ + + +++ + ++ ET
Sbjct: 2363 LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2422
Query: 1474 CKSLEEKL----KEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEP 1529
L ++L +E+ES ++ S + I+ L P E E ++ E K +E
Sbjct: 2423 MNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP---ELEVVLTEDALKSLEN 2479
Query: 1530 KSHHTL--KIAHQTIANMQARLNQKEEVL-----------KKYQRLLEKAREEQREIVKK 1576
+++ + +I N++ RL Q E + K+ + + E+ + E + KK
Sbjct: 2480 QTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKK 2539
Query: 1577 --------HEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQ 1628
E+ L +++L+A KF Q + + N + +R E+
Sbjct: 2540 IVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGS 2599
Query: 1629 TVAEQDDSLSSLLVKLKKVSQDL---ERQREITELKVKEFENIKLQLQE--------NHE 1677
++ +S L ++ ++ L + Q EI E V E E L+LQ+ E
Sbjct: 2600 DISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQRE 2659
Query: 1678 DEVKKVKAEVEDLKYLLD--QSQKESQCLKSELQAQKEAN--SRAPTTTMRNLVERLKSQ 1733
E K+ +VE LK + S +ES +EL+A + + ++A + + E+L+ +
Sbjct: 2660 KEKKRSPQDVEVLKTTTELFHSNEESGFF-NELEALRAESVATKAELASYKEKAEKLQEE 2718
Query: 1734 LALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ-----IVDRHTRELK 1788
L +KE +L + L ++R + A E+ I +KE VQ+ + + +L
Sbjct: 2719 LLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL---EKEDETEVQESKKACMFEPLPIKLS 2775
Query: 1789 TQVEDLNENLLKLKEALKT---------------SKNRENSLTDNLNDLNNELQKKQKAY 1833
+ + LK+ + +T S+ +T+ ++ +++K Q+
Sbjct: 2776 KSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQE-- 2833
Query: 1834 NKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVE 1893
L E +D E+ + L + ++ + + ++ E ++
Sbjct: 2834 ---LHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELA 2890
Query: 1894 EVDLKPMKEKNAKEELIRWEEG------KKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLK 1947
D +E + + W +G + + EG + +E E + K++ L
Sbjct: 2891 HSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEG---RGEESESATDSFPKKIKGLL 2947
Query: 1948 DLFAKADKEKLTLQRKLKTTGM--TVDQVLGIRALESEKELEELKKRNLDLENDILYMRA 2005
+ L+L + G ++ QV SE LEE +K ++ + + +
Sbjct: 2948 RAVHNEGMQVLSLTESPYSDGEDHSIQQV-------SEPWLEE-RKAYINTISSLKDLIT 2999
Query: 2006 HQALPRDSVVEDLHLQNRYLQ----EKLHALEKQFSKD-----TYSKPSISGIESDDHCQ 2056
L R++ V D + E L AL++ F ++ + ++ + + D
Sbjct: 3000 KMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVG 3059
Query: 2057 REQELQKENLKLSSENIELKFQLEQANK-DLPRLKNQVRDLKEMCEFLKKEKAEVQRKLG 2115
L++ ++ + +E + +E K D L ++++ L
Sbjct: 3060 LLNCLEQ---RIQEQGVEYQAAMECLQKADRRSLLSEIQAL------------------- 3097
Query: 2116 HVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTS--EKMANIEQENEKL 2173
H + +GR E E + + +Q++ Q+ + L+S ++ ++++
Sbjct: 3098 HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSSE 3157
Query: 2174 KAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEIL 2233
K + +LK+ L Q + E+ K K + E E R E+K +TD + +L
Sbjct: 3158 KMVVAELKSELA-QTKLELETTLKAQHKHLKELEAFRLEVKDKTD----------EVHLL 3206
Query: 2234 NEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSI 2293
N+ + + ++ + LQ+A LE +K +S + +L++L+ + + Q
Sbjct: 3207 NDTLASE-QKKSRELQWA------LEKEKAKLGRS---EERDKEELEDLKFSLESQKQRN 3256
Query: 2294 TDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVL--------R 2345
L L++ +++Q +N+ + +E Q + EQG ELQVL R
Sbjct: 3257 LQLNLLLE---QQKQLLNESQQKIESQRML---YDAQLSEEQGRNLELQVLLESEKVRIR 3310
Query: 2346 LANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQ-LKMSDL--EKQHL 2402
+ LD+E+ EL Q++++ + +P D LKE K LE + ++ +L E +
Sbjct: 3311 EMSSTLDRER-ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKY 3369
Query: 2403 KEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452
K + + ++++E + ++ + E KK L+ KV+ L QL
Sbjct: 3370 KLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQL 3419
Score = 170 bits (431), Expect = 1e-41
Identities = 464/2277 (20%), Positives = 935/2277 (41%), Gaps = 363/2277 (15%)
Query: 84 ENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKK 143
E QL+ +L + + QQ+ T LR + + Q +R+ ED E+ E+ K+
Sbjct: 1584 EEQLEDMRQELVRQYQEHQQA-----TELLR------QAHMRQMERQREDQEQLQEEIKR 1632
Query: 144 VNEQLALRNEEAENENSKLRRENKRLKK----------KNEQLC----------QDIIDY 183
+N QLA R+ +NEN RE L++ E+LC Q+ +
Sbjct: 1633 LNRQLAQRS-SIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
Query: 184 QKQIDSQ--KETLLSRRGED------SDYRSQLSKKNYELIQYLDEIQTLTEANEKI--- 232
Q +++ Q KE L R+ ED S+ R L K N L++ L E+ T A E+
Sbjct: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
Query: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLL 292
V R + +S + ++ +K+ VH+ +H ++ + +
Sbjct: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHE------------EHTRVTDESIPSYS 1799
Query: 293 KSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMA 352
S +D + W S +E E Q L +R ++D + +M
Sbjct: 1800 GSDMPRND---------INMW----SKVTEEGTELSQRL--VRSGFAGTEIDPENEELML 1844
Query: 353 LQQGIQER-DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411
I R + ++ L E + + + ++E +L E R K +T
Sbjct: 1845 ---NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEAT----------- 1890
Query: 412 TLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQ 471
E K E E ++R +++ VE K G+ D + K
Sbjct: 1891 ------ESLKCQEELRERLHEESRAREQLAVELSK--------AEGVIDGYADEKT---- 1932
Query: 472 IKIRDREIEILTKEINKLELKI---SDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQ 528
+ +R+I+ T I++LE ++ S+ L E EA ++++ E + + R + +K
Sbjct: 1933 --LFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL-----SRQKEAMKA 1985
Query: 529 QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588
+ E Q LL+E E L +E+L+++ + ++ + K+ + ++++ E +S+
Sbjct: 1986 EAGPVEQQ-LLQETEKLMKEKLEVQCQAEKVRDDLQKQ-----VKALEIDVEEQVSRFIE 2039
Query: 589 I-SERKLDLLSLKNMSEAQSK-----NEFLSRELIEKERD----------LERSRTVIAK 632
+ E+ +L+ L+ ++A K +FL + I++E + LE+ V+ +
Sbjct: 2040 LEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPR 2099
Query: 633 FQ-------NKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLI---IPSLER- 681
FQ ++++L K+ + E+L + +++Q+D + E + + LE+
Sbjct: 2100 FQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQA 2159
Query: 682 -LVNA-----IESKNAEGIFDA------SLHLKAQVDQLTGRNEE---LRQELRESRKEA 726
LV+A +E + G +A + L+A+ D + + +E L ++L + R+E
Sbjct: 2160 LLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREEL 2219
Query: 727 INYSQQLAKANLKIDHLEKE-TSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLI 785
N ++++ + +++++ +KE T+ L++ E N +FK G+A + +++Q+++++
Sbjct: 2220 ENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVL 2279
Query: 786 --HLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEE 843
Q ++ KE ++ L + + ++ + + + K L + E +E
Sbjct: 2280 FGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQE 2339
Query: 844 --KRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYT 901
KR E++++Q N ++ LQ E+ I + S L SL Q
Sbjct: 2340 CVKRNREEEIEQ-------LNEVIEKLQ---QELANIGQKTSMNAHSLSEEADSLKHQLD 2389
Query: 902 TLV----ELERQLRKENEK---QKNELLSME---AEVCEKIGCLQRFKEMAIFKIAALQK 951
++ LE+Q+ NE+ KN L ++ +++ L+R +E + +Q
Sbjct: 2390 VVIAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE----SVEKIQS 2445
Query: 952 VVDNSVSLSELELANKQYNELTAKYRDILQK-DNMLVQRT------SNLEHLECENISLK 1004
+ +NSV+++ L+ + D L+ +N ++ ++ +LE + L+
Sbjct: 2446 IPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLE 2505
Query: 1005 EQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEM 1064
V + + EL +++ +++ + ET++ KK + IV ++
Sbjct: 2506 STVSAKDLELTQCYKQIKDMQEQGQFETEM-------LQKKIVNLQKIVEEKVAAALVSQ 2558
Query: 1065 KELNERQR-AEHCQK----MYEHLRTSLKQMEE-RNFELETKFAELTK--INLDAQKVEQ 1116
+L Q A+ CQ E RT+++ + + R EL + + LT L++Q VE
Sbjct: 2559 IQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEM 2618
Query: 1117 MLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSR 1176
+ + K + + +LE EK +EL+ KL E ++ +R+ E ++ +
Sbjct: 2619 ----HTSLILEKEQVEIAEKNVLEKEKKLLELQ----KLLEGNEKKQREKE---KKRSPQ 2667
Query: 1177 DKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNL 1236
D EV +L +S + + L +V+ + A+ K E + +L E
Sbjct: 2668 DVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMT 2727
Query: 1237 RLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQ-FSGALPLAQQEKFSKTMIQLQN 1295
L++ L + L A+ + K +Q ++ LP+ K SK++ +
Sbjct: 2728 SLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPI----KLSKSIASQTD 2783
Query: 1296 DKLKIMQEMKNSQQEHRNMENK-TLEMELKLKGLEELISTLKDTKGAQKVINWH----MK 1350
LKI + Q +N + L+ E + + E+IS T+ +K+ H +
Sbjct: 2784 GTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQF--TEKIEKMQELHAAEILD 2841
Query: 1351 IEELRLQELK-LNRE----LVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQM 1405
+E + E + L RE + KEE L +I S E+ + + + R++
Sbjct: 2842 MESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAY-QTREI 2900
Query: 1406 AWDQREVDLERQLDIFDRQQNEILN--AAQKFEEATGSIPDPSLPLPNQLEIALRKI-KE 1462
D + + + Q +I + ++ E AT S P +++ LR + E
Sbjct: 2901 CSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDS-------FPKKIKGLLRAVHNE 2953
Query: 1463 NIRIILETRATCKSLEEKLKEKESALRLAEQ-----NILSRDKVINELRLRLPATAE--- 1514
++++ T + E+ ++ S L E+ I S +I +++L+ A
Sbjct: 2954 GMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSS 3013
Query: 1515 ---------REKLIAELGRKEMEPKSHHTLKIAHQT------IANMQARLNQKEEVLK-- 1557
R +L+ L + +E +S L A +T + LN E+ ++
Sbjct: 3014 QSHESFSDWRGELLLALQQVFLEERS--VLLAAFRTELTALGTTDAVGLLNCLEQRIQEQ 3071
Query: 1558 --KYQRLLEKAREEQREIVKKHEEDLH--ILHHRLELQADSSLNKFKQTAWDL---MKQS 1610
+YQ +E ++ R + + LH + ++ L+ + K Q + KQS
Sbjct: 3072 GVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS 3131
Query: 1611 ---PTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFEN 1667
V + R E+++ ++ + ++ L +L + +LE + +KE E
Sbjct: 3132 QMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEA 3191
Query: 1668 IKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLV 1727
+L EVK EV L L QK+S+ L+ L+ +K R+ L
Sbjct: 3192 FRL--------EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEEL- 3242
Query: 1728 ERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTREL 1787
E LK L +KQ+ LLE + ++ ++++I S +A L+ +Q + + L
Sbjct: 3243 EDLKFSLE-SQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVL 3301
Query: 1788 ----KTQVEDLNENLLKLKE---ALKTSKNRENS-----LTDNLNDLNNELQKKQKAYNK 1835
K ++ +++ L + +E L++S S D L +L +L++K +
Sbjct: 3302 LESEKVRIREMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVE 3361
Query: 1836 ILREKEEI------DQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLE 1889
+L E E+ ++ E RQ+ R T + + T+ Q + ELQ KV+ L+ QLE
Sbjct: 3362 LLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEG-QKKMHELQSKVEDLQRQLE 3420
Query: 1890 GKVEEV---DLKPMKEKNAKEELIRWE---EGKKWQAKIEGIRNKLKEKEGEVFTLTKQL 1943
K ++V DL+ + + +E + E E K+ +I + L E T +
Sbjct: 3421 EKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESRRI--LYQNLNEPTTWSLTSDRTR 3478
Query: 1944 NTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYM 2003
N + ++K+ + K ++ G E E+ K + + + +L
Sbjct: 3479 NWVL-------QQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQ 3531
Query: 2004 RAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDT---YSKPSISGIESDDHCQREQE 2060
+A + L ++ ++ + ++QE + + Q K T +PS+ + C E
Sbjct: 3532 KASERLQFETADDEDFI---WVQENIDEIILQLQKLTGQQGEEPSL--VSPSTSCGSLTE 3586
Query: 2061 LQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGS 2120
+L +N EL + Q ++ L+N V L+E + ++ G+
Sbjct: 3587 ------RLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQ------------TGA 3628
Query: 2121 GRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAEL 2177
GR + L +E + +++ + + + E E KLKAEL
Sbjct: 3629 GRDNSSRFSLNGGAN-----IEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL 3680
Score = 75.1 bits (183), Expect = 8e-13
Identities = 147/697 (21%), Positives = 293/697 (42%), Gaps = 91/697 (13%)
Query: 243 LEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPI 302
LE+ +QE EY + + D + + H Q+ +++T LK + E + P
Sbjct: 3064 LEQRIQEQGV---EYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT--LKREQESEKPS 3118
Query: 303 MVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQ--LDADKSNVMALQQGIQER 360
+ +++ K +++E Q L +++++ Q L ++K V L+ + +
Sbjct: 3119 QELLEYNIQQ-------KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT 3171
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT 420
+++ + ++ KE+E ++D +E+ Q+ ++Q L+ KEK
Sbjct: 3172 KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALE--KEKA 3229
Query: 421 KEAERTAELAEADAREKDKELVEALK-RLKDYESGVYGLEDAVVEIKNCKN--QIKIRDR 477
K + E+DKE +E LK L+ + L + + K N Q KI +
Sbjct: 3230 KLGR---------SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQ 3280
Query: 478 EI----EILTKEINKLELKISDFLDENEALRERVGLEPKTMIDL-----TEFRNSKHLKQ 528
+ ++ ++ LEL++ L E+E +R R E + +D + ++S Q
Sbjct: 3281 RMLYDAQLSEEQGRNLELQV---LLESEKVRIR---EMSSTLDRERELHAQLQSSDGTGQ 3334
Query: 529 QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588
+ ++ LLKE++ EE+ +I ++ E K S T + + + +
Sbjct: 3335 SRPPLPSEDLLKELQKQLEEK---HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3391
Query: 589 ISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLE 648
+E++ + K M E QSK E L R+L EK + + + + Q ++E ++ + E
Sbjct: 3392 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3451
Query: 649 EGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLK--AQVD 706
E +E + + + +P T+ + S +R N + + EG S + K
Sbjct: 3452 E-KRESRRILYQNLNEP------TTWSLTS-DRTRNWVLQQKIEGETKESNYAKLIEMNG 3503
Query: 707 QLTGRNEEL---RQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGI 763
TG N EL RQ+L + + Q A L+ + + E + Q ++ +
Sbjct: 3504 GGTGCNHELEMIRQKL-QCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQ 3562
Query: 764 DL-------PDGIAPSSA-----SIINSQNEYLIHLLQELENKEKKLKNLEDSLED---Y 808
L P ++PS++ + QN L + +L ++ L+N+ LE+ +
Sbjct: 3563 KLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRW 3622
Query: 809 NRKFAVIRHQQSL--------LYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKE 860
R+ R S + SEKE W E T+++ ++ E +V + +++
Sbjct: 3623 YRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3682
Query: 861 YNNLLNALQMDSDEM-------KKILAENSRKITVLQ 890
++LL L DS+ + K + AE+ RK + Q
Sbjct: 3683 -DSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQ 3718
Score = 50.1 bits (118), Expect = 3e-05
Identities = 76/388 (19%), Positives = 173/388 (44%), Gaps = 50/388 (12%)
Query: 2106 EKAEVQRKLGHVRGS-GRSG-KTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKM 2163
E E+ R+L +R + G G + + E E I ++ ++ +Q ++ T +
Sbjct: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDE-TMREF 228
Query: 2164 ANIEQENEKLKAELEKLKAHLGHQLSMHYESKT---KGTEKIIAENERLRKELKKETDAA 2220
+ ++++KL+ + ++L+A + S H + + ++I+ ++L ++ D
Sbjct: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288
Query: 2221 EKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLK 2280
+K + L EK+ V E K+++ + Q + ET ++
Sbjct: 289 KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK----------------ETIIE 332
Query: 2281 ELETDIAKKNQSITDLKQLVKEATE-----REQKVNKYNEDLEQQIKILKHVPEGAETEQ 2335
EL T I ++ + +LK + A + +EQ V K E ++++ + ++ +
Sbjct: 333 ELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 392
Query: 2336 GLKR---ELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQL 2392
+K+ ++ L+ NH+ + + +++ ++E + T +QL+ ++ ++ Q
Sbjct: 393 EIKQLMGTVEELQKRNHKDSQFETDIVQRME--------QETQRKLEQLRAELDEMYGQQ 444
Query: 2393 KMS---DLEKQHLK--EEIK-KLKKELENFDPSFFE---EIEDLKYNYKEEVKKNILLEE 2443
+ +L +QH+ EE+K + K E+EN S+ + +K + NI L++
Sbjct: 445 IVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQD 504
Query: 2444 ---KVKKLSEQLGVELTSPVAASEEFED 2468
+ +KL E+LG+ L A + ED
Sbjct: 505 TNSQKEKLKEELGLILEEKCALQRQLED 532
Score = 37.0 bits (84), Expect = 0.24
Identities = 40/158 (25%), Positives = 66/158 (41%), Gaps = 17/158 (10%)
Query: 14 DPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEV 73
D +D +E D +++ L K+ + E+ V ++ Q EL +
Sbjct: 3543 DDEDFIWVQENIDEIILQLQKLTGQQ--GEEPSLVSPSTSCGSLTERLLRQNAELT-GHI 3599
Query: 74 EKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRD--TRFLRNEICQLEKQLEQKDREL 131
+ EE+ N L+ VMKLE ++ +Q+ GRD +RF N +E +
Sbjct: 3600 SQLTEEK----NDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIAS----- 3650
Query: 132 EDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRL 169
EKE+ +K+ Q +L+ EAE K N L
Sbjct: 3651 ---EKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSL 3685
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 222 bits (565), Expect = 4e-57
Identities = 495/2630 (18%), Positives = 1109/2630 (42%), Gaps = 379/2630 (14%)
Query: 20 RQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEE 79
++E+ + K++V E++ +K+ ++ K + QE E +EE+ E
Sbjct: 290 KKEDFTMQISFLQEKIKVYEMEQDKK---------VENSNKEEIQEKETIIEELNTKIIE 340
Query: 80 QAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKEL- 138
+ K K ++L+++L A + G +L++Q+ QK++E+++M+ EL
Sbjct: 341 EEK-------KTLELKDKLTTADKLLG------------ELQEQIVQKNQEIKNMKLELT 381
Query: 139 ---EKEKKVNE---QLALRNEEAENENSK--------LRRENKRLKKKNEQLCQDIID-Y 183
+KE++ +E QL EE + N K ++R + ++K EQL ++ + Y
Sbjct: 382 NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441
Query: 184 QKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQN---QEMR 240
+QI K+ L+ R + ++ E+ L +T ++I++ N E+
Sbjct: 442 GQQIVQMKQELI--RQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELN 499
Query: 241 KNLEESVQEMEKMTDEYNRMK----AIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKN 296
L+++ + EK+ +E + A+ Q ++++++L + Q Q + + N
Sbjct: 500 IKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLN 559
Query: 297 EEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQG 356
E + + K E ++ +S+ + +E + K+K L+ +K+ V+
Sbjct: 560 EAHKSLSTVEDLKAE---IVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAE 616
Query: 357 IQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDIL 416
QE + + ++ T+ + + +E+ K + EDL E++ L + + +D L
Sbjct: 617 SQEAELE-RLRTQLLFSHEEELSK---LKEDL--EIEHRINIEKLKDNLGIHYKQQIDGL 670
Query: 417 KEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGL--EDAVVEIKNCKNQIKI 474
+ + + T + + + K +L+ + +LKD + + E+ ++I + +I+I
Sbjct: 671 QNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEI 730
Query: 475 RDRE-----------------IEILTKEI----NKLELKISDFLDENEALRERVGLEPKT 513
+E E+L K++ N L+ K + EN L++ E KT
Sbjct: 731 LRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD----EKKT 786
Query: 514 MIDLTEFRNSKHLKQQ-------QYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKR 566
+ D+ + +++ + ++++ + KEIE L EE DLK++ Q+ +E K+
Sbjct: 787 LEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQ 846
Query: 567 SATSGLTTE--DLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLE 624
T + ++N E + + + K DL KN E + K++ + + +E L+
Sbjct: 847 RNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKL---KALNEELHLQ 903
Query: 625 RSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVN 684
R K ++ + +E+K + E L+ + ++KD T+ ++ LE
Sbjct: 904 RINPTTVKMKSSV---FDEDKTF---VAETLEMGEVVEKD-------TTELMEKLE---- 946
Query: 685 AIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLE 744
+ + + L Q+ Q G L +E++ ++E S + + + I+H
Sbjct: 947 -VTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNR 1005
Query: 745 KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDS 804
E ++ S+++ + + A S S +N ++ E + + + E+S
Sbjct: 1006 AENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEES 1065
Query: 805 LEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNL 864
++ ++ H S+ + L + T +E+ +++E L+ + ++++
Sbjct: 1066 KQEQ----LILDHLPSVTKESSL--RATQPSENDKLQKELNVLKSEQNDLRLQMEAQRIC 1119
Query: 865 LNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSM 924
L+ + + + EN + + + E+ + Q + EL++ + E + K +
Sbjct: 1120 LSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGD 1179
Query: 925 EAEVCEK-IGCLQR-FKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQK 982
E + IG LQ+ E + + L V+ + + N + E + Y +
Sbjct: 1180 EGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENED 1239
Query: 983 DNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQET-----KLGNE 1037
+ R + E + L + E NK L + + + W Q+T + G E
Sbjct: 1240 PELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTR----LSKIWGQQTDGMKLEFGEE 1295
Query: 1038 SSMDKAKK------SITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQM- 1090
+ + + +TN + + ++ K + +++L + + E Q++ E L +SL+Q
Sbjct: 1296 NLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQEL-ESLISSLQQQL 1354
Query: 1091 --EERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRIL---ELEKNE 1145
E+N+E AE+ + Q V + S ++++D QR + K
Sbjct: 1355 KETEQNYE-----AEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKN 1409
Query: 1146 MELKVEVSK---LREISDIARRQVEILNAQQQSR-DKEVESLRMQLLDYQAQSDEKSLIA 1201
++ +E S ++E ++I V++L Q Q + ++EV + + + AQ E S I+
Sbjct: 1410 IDGTIEFSGEFGVKEETNI----VKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRIS 1465
Query: 1202 KLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAK 1261
++ S + + A + + + + +D K + + + + +
Sbjct: 1466 GGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEF--KPLSKELGE 1523
Query: 1262 HLRQTIQSLRR-----QFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMEN 1316
H ++ + S + + +E FSK DK I+++ + + +M+
Sbjct: 1524 HGKEILLSNSDPHDIPESKDCVLTISEEMFSK-------DKTFIVRQSIHDEISVSSMDA 1576
Query: 1317 KTLEM--ELKLKGL-EELISTLKDTKGAQKVINW-HMKI--------EELRLQELKLNRE 1364
M E +L+ + +EL+ ++ + A +++ HM+ E+L+ + +LNR+
Sbjct: 1577 SRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQ 1636
Query: 1365 LVKDKEEIKYLNNIISEYERTISSLEE-EIVQQNKFHEERQMAWDQREVDLERQLDIFDR 1423
L + N++SE ER + LEE E ++Q ++ + R + Q +
Sbjct: 1637 LAQRSSIDN--ENLVSERERVL--LEELEALKQLSLAGREKLCCELRNSSTQTQNG--NE 1690
Query: 1424 QQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENI-RIILETRATCKSLEEKLK 1482
Q E+ K +E D + + AL+K + +I+LE T ++EE +
Sbjct: 1691 NQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750
Query: 1483 EKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPK--SHHTLKIAHQ 1540
L + +++ S+ L R A A + + E + + S+ +
Sbjct: 1751 RH--VLGILDRSSKSQSSA--SLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRN 1806
Query: 1541 TIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFK 1600
I NM +++ EE + QRL+ ++ EI ++EE + + RL+ + L
Sbjct: 1807 DI-NMWSKVT--EEGTELSQRLV-RSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAIS 1862
Query: 1601 QTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVK--LKKVSQDLERQREIT 1658
+T+ L T M ++ ++ ++ SL + L++ + R RE
Sbjct: 1863 ETSSQLEHAKVTQTEL---------MRESFRQKQEATESLKCQEELRERLHEESRAREQL 1913
Query: 1659 ELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRA 1718
+++ + E + + + DE + ++++ ++D+ ++E C + LQ
Sbjct: 1914 AVELSKAEGVI----DGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ--------- 1960
Query: 1719 PTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ 1778
L+++ +++++ LSR ++AE ++ + + L VQ
Sbjct: 1961 ----------ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC 2010
Query: 1779 IVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILR 1838
++ +L+ QV+ L ++ + + +N+ +L N L+K+ + K L
Sbjct: 2011 QAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLD 2070
Query: 1839 EKE-EIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV-D 1896
E+ + + E D +++I++L L+ P Q + E R+V++L N L+ K ++ +
Sbjct: 2071 EQAIDREHERDVFQQEIQKLEQQLKVVP---RFQPISEHQTREVEQLANHLKEKTDKCSE 2127
Query: 1897 LKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVF---------TLTKQLNTLK 1947
L KE+ ++ R EE +K + ++ + L ++ + F +L QL +
Sbjct: 2128 LLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAER 2187
Query: 1948 DLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAH- 2006
D + +KE L+ +L E+ EEL+ +N +++ L+M+
Sbjct: 2188 DAIDRKEKEITNLEEQL------------------EQFREELENKNEEVQQ--LHMQLEI 2227
Query: 2007 QALPRDSVVEDLHLQNRYLQEKLH----ALEKQFSKDTYSKPSISGIESDDHCQREQELQ 2062
Q + +++L +N+ ++ + A+++ + T + + G + ++E E+
Sbjct: 2228 QKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEID 2287
Query: 2063 KENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGR 2122
+ N +++ +LK + NK + +RDL+ E L ++ V+R
Sbjct: 2288 QLNEQVTKLQQQLKITTD--NKVIEEKNELIRDLETQIECLMSDQECVKRNR-------- 2337
Query: 2123 SGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKA 2182
E+ I + +V+EK+Q+E + G TS ++ +E + LK +L+ +
Sbjct: 2338 --------EEEIEQLNEVIEKLQQELANI----GQKTSMNAHSLSEEADSLKHQLDVV-- 2383
Query: 2183 HLGHQLSMHYESKTKGTEKIIAEN---------ERLRKEL---KKETDAAEKLR-IAKNN 2229
+ +L++ + +T E +N +L +EL K+E ++ EK++ I +N+
Sbjct: 2384 -IAEKLALEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENS 2442
Query: 2230 LEIL-----NEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELET 2284
+ + +K +++ T L+ E++ + + SI+ ET+L +LE+
Sbjct: 2443 VNVAIDHLSKDKPELEVVLTEDALKSLENQ-TYFKSFEENGKGSII---NLETRLLQLES 2498
Query: 2285 DIAKKNQSITDLKQLVKEATER--------EQKVNKYNEDLEQQIKI-------LKHVPE 2329
++ K+ +T + +K+ E+ ++K+ + +E+++ L+ V E
Sbjct: 2499 TVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQE 2558
Query: 2330 GAE-----------------------TEQGLKRELQVLRLANHQLDKEKAELIHQIEANK 2366
A+ E L ++ L L +L+ + E+ + K
Sbjct: 2559 YAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEK 2618
Query: 2367 DQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELE-----------N 2415
+Q I + + L+++ K LE Q + EK+ ++E K+ +++E N
Sbjct: 2619 EQ----VEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSN 2674
Query: 2416 FDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEE 2465
+ FF E+E L+ + +EK +KL E+L V+ T+ + ++
Sbjct: 2675 EESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKD 2724
Score = 221 bits (562), Expect = 9e-57
Identities = 494/2493 (19%), Positives = 1004/2493 (40%), Gaps = 450/2493 (18%)
Query: 113 LRNEICQLEKQLEQKDRELEDM---------------EKELEKEKKVNEQLALRNEEAEN 157
+ +E+ + ++E+ +RELE+M E +++ + QL ++A
Sbjct: 160 MESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARR 219
Query: 158 ENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQ 217
E + RE L +++++L Q Q ETL + S S +L+Q
Sbjct: 220 EKDETMREFLELTEQSQKL-----QIQFQQLQASETLRN---------STHSSTAADLLQ 265
Query: 218 YLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKE 277
+I T + E+ + ++ +K E+ ++ + + ++K + D ++ KE
Sbjct: 266 AKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQE---KIKVYEMEQDKKVENSNKE 322
Query: 278 NDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREK 337
++QE +++ N + ++ K E K L++ D + E Q+ + ++
Sbjct: 323 ------EIQEKETIIEELNTK----IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQE 372
Query: 338 LKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKN----TCIIEDLKNELQ 393
+KN +L+ S +Q ++ +IK L VE+ K K+ T I++ ++ E Q
Sbjct: 373 IKNMKLELTNS-----KQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQ 427
Query: 394 RNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYES 453
R K ++ M Q + + +E + + A++ E R K +
Sbjct: 428 R-KLEQLRAELDEMYGQQIVQMKQELIR--QHMAQMEEMKTRHKGE-------------- 470
Query: 454 GVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKT 513
+E+A+ N I + + +I+++ IN+L +K+ D + E L+E +GL
Sbjct: 471 ----MENALRSYSN----ITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL---- 518
Query: 514 MIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLT 573
K Q+Q + L E ++ R + ++ ++ + S L
Sbjct: 519 ------ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLK 572
Query: 574 TEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRT-VIAK 632
E ++ +E+ + + E ++ +K + KN L R +E +LER RT ++
Sbjct: 573 AEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFS 632
Query: 633 FQNKLKELVEE--------------------NKQLEEGMKEILQAIKEMQKDPD---VKG 669
+ +L +L E+ +Q++ E+ Q I+ MQ + D K
Sbjct: 633 HEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQ 692
Query: 670 GETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINY 729
+ L I L+ L ++ + +E + Q+++L E LRQE KE
Sbjct: 693 NQLILEISKLKDLQQSLVNSKSE-------EMTLQINELQKEIEILRQE----EKEKGTL 741
Query: 730 SQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQ 789
Q++ + LK + LEK+ +++ E DL + A
Sbjct: 742 EQEVQELQLKTELLEKQ---MKEKEN--------DLQEKFA------------------- 771
Query: 790 ELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEK---ETWKTESKTIKEEKRK 846
+LE + LK+ + +LED + + ++ L++ + + K W+ E + + EE
Sbjct: 772 QLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENED 831
Query: 847 LEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVEL 906
L+ Q Q ++++ N + + + +VN + L +Y L+++
Sbjct: 832 LKQQCIQLNEEIEKQRNTFSFAEKN-----------------FEVNYQELQEEYACLLKV 874
Query: 907 ERQLRKENEKQKNELLSMEAEVCEKIGCLQR------------FKEMAIFKIAALQ--KV 952
+ L KQ+ E S + E++ LQR F E F L+ +V
Sbjct: 875 KDDLEDSKNKQELEYKSKLKALNEELH-LQRINPTTVKMKSSVFDEDKTFVAETLEMGEV 933
Query: 953 V--DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESI 1010
V D + + +LE+ ++ EL+ + D+ ++ L Q+ + L E SLK++ E +
Sbjct: 934 VEKDTTELMEKLEVTKREKLELSQRLSDLSEQ---LKQKHGEISFLNEEVKSLKQEKEQV 990
Query: 1011 N---KELE--ITKEKLHTIEQAWEQETKL----------GNESSMDKAKKSITNSDIVSI 1055
+ +ELE I + ++ Q + L G E S+ K KS + +
Sbjct: 991 SLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMV 1050
Query: 1056 SKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVE 1115
K++ E + E + E Q + +HL + K+ R T+ +E K
Sbjct: 1051 EDKVS-FENMTVGEESKQE--QLILDHLPSVTKESSLR----ATQPSENDK--------- 1094
Query: 1116 QMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQS 1175
L+ EL +L+ E+N++ L++E ++ + ++ +
Sbjct: 1095 --LQKEL--------------NVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENE 1138
Query: 1176 RDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA---------LGKLESITS 1226
+DK + SL+ +L+ AQ ++ + K+HQ + ++ T +GKL+ S
Sbjct: 1139 KDKALCSLKEELI--FAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVS 1196
Query: 1227 K-----LQKM-----EAYN--LRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQF 1274
+ LQ + E Y L+ E ++KE + Y + R +Q +
Sbjct: 1197 EECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENM 1256
Query: 1275 SGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELIST 1334
L +E ++K ++ LQ KI + + + EN E E + + ++
Sbjct: 1257 HTLLNKVTEE-YNKLLV-LQTRLSKIWGQQTDGMKLEFGEENLPKE-ETEFLSIHSQMTN 1313
Query: 1335 LKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIV 1394
L+D +N K+ L +D E+ K L + E E ISSL++++
Sbjct: 1314 LEDID-----VNHKSKLSSL------------QDLEKTK-LEEQVQELESLISSLQQQLK 1355
Query: 1395 QQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQL- 1453
+ + +E EI ++ + + S PSLP+ + +
Sbjct: 1356 ETEQNYEA------------------------EIHCLQKRLQAVSESTVPPSLPVDSVVI 1391
Query: 1454 -EIALRK-------IKENIRIILETRATCKSLEE----KLKEKESALRLAEQNILSRDKV 1501
E ++ +K+NI +E EE KL EK+ +L E+ KV
Sbjct: 1392 TESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVA----KV 1447
Query: 1502 INELRLRLPATAEREKLIAELGRKE--MEPKSHHTLKIAHQTIANMQARLNQKEEVLKKY 1559
I + + A A++ +L G KE K H + Q N + +L+Q + + +
Sbjct: 1448 IVSMSI---AFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFN-EMKLSQDQIGFQTF 1503
Query: 1560 QRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKH 1619
+ + K +EE + + K+ E H + L ++S + ++ ++ S +K
Sbjct: 1504 ETVDVKFKEEFKPLSKELGE-----HGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKT 1558
Query: 1620 FI--RLAEMEQTVAEQDDSLSSLL--VKLKKVSQDLERQREITELKVKEFENIKLQLQEN 1675
FI + E +V+ D S +L +L+ + Q+L RQ + + + ++ E
Sbjct: 1559 FIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER 1618
Query: 1676 HEDEVKKVKAEVEDL-KYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQL 1734
++ ++++ E++ L + L +S +++ L SE + R L+E L+
Sbjct: 1619 QREDQEQLQEEIKRLNRQLAQRSSIDNENLVSERE--------------RVLLEELE--- 1661
Query: 1735 ALKEKQQKALSRALLELRAEMTAAAE------ERIISATSQKEAHLNVQQIVDRHTRELK 1788
ALK+ + ELR T E +KE + + +
Sbjct: 1662 ALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNER 1721
Query: 1789 TQVEDLNENLLK-LKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQE- 1846
++ N LLK L E +KT+ E ++ ++ + + K Q + + I R + E +
Sbjct: 1722 YALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKS 1781
Query: 1847 --NDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQL-EGKVEEVDLKPMKEK 1903
++E R G + N ++ ++ + +L +L ++ P E+
Sbjct: 1782 CVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEE 1841
Query: 1904 NAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEV-FTLTKQLNTLKDLFAKADK--EKLTL 1960
+ + QA +E + + E ++ Q +++ F + + E L
Sbjct: 1842 ------LMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKC 1895
Query: 1961 QRKLK---------TTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPR 2011
Q +L+ + V+ ++ + + L +R + + DI+ + L
Sbjct: 1896 QEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
Query: 2012 DSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSE 2071
+ +++L + + +QE+ L +Q + EQ+L +E KL E
Sbjct: 1956 SNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPV-----------EQQLLQETEKLMKE 2004
Query: 2072 NIELKFQLEQANKDLPR-LKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPEL 2130
+E++ Q E+ DL + +K D++E + + E +L +R ++ L
Sbjct: 2005 KLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQA------L 2058
Query: 2131 EKTIGLMKKVVEK--VQRENEQLKKASGILTSEKMANI----EQENEKLKAELEKLKAHL 2184
EK + M+K +++ + RE+E+ I E+ + + +E E+E+L HL
Sbjct: 2059 EKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHL 2118
Query: 2185 GHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEET 2244
+ KT +++ E+L++++++ + EKL LE L E
Sbjct: 2119 --------KEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELE------QALLVED 2164
Query: 2245 GKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEAT 2304
K E++ P+L E +L+ I +K + IT+L++ +++
Sbjct: 2165 RKHFGAVEAK-PELS---------------LEVQLQAERDAIDRKEKEITNLEEQLEQFR 2208
Query: 2305 EREQKVNKYNEDLEQQIKILK-----HVPEGAETEQGLKRELQVLRLANHQLDKEKAELI 2359
E + N+ + L Q++I K + E + + K +++ L LA + D +
Sbjct: 2209 EELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQ 2268
Query: 2360 HQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPS 2419
H + Q E + + DQL E++ L+ QLK++ K + EE +L ++LE
Sbjct: 2269 HVLFGKFAQIIQEKEV-EIDQLNEQVTKLQQQLKITTDNK--VIEEKNELIRDLETQIEC 2325
Query: 2420 FFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452
+ E +K N +EE+++ L E ++KL ++L
Sbjct: 2326 LMSDQECVKRNREEEIEQ---LNEVIEKLQQEL 2355
Score = 181 bits (458), Expect = 1e-44
Identities = 394/1983 (19%), Positives = 841/1983 (42%), Gaps = 262/1983 (13%)
Query: 19 PRQEELADNLLISLSKV--EVNELKSEKQENVIHLFRITQSLM-------KMKAQEVELA 69
P EEL N+ L ++ E SE + H ++TQ+ + K +A E
Sbjct: 1837 PENEELMLNISSRLQAAVEKLLEAISETSSQLEHA-KVTQTELMRESFRQKQEATESLKC 1895
Query: 70 LEEVEKAGEEQAKFENQLKTKVMKLENELE--MAQQSAGGRDTRFLRNEICQLEKQLEQK 127
EE+ + E+++ QL ++ K E ++ +++ R + + I +LE++L
Sbjct: 1896 QEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCA 1955
Query: 128 DRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQI 187
L+++E E ++ ++ E L+ + E + E + ++ L ++ E+L ++ ++ Q Q
Sbjct: 1956 SNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ---LLQETEKLMKEKLEVQCQA 2012
Query: 188 DSQKETLLSR-RGEDSDYRSQLSKKNYELIQYLD-EIQTLTEANEKIEVQNQEMRKNLEE 245
+ ++ L + + + D Q+S+ EL Q + E+ L + N+ +E Q ++MRK L+E
Sbjct: 2013 EKVRDDLQKQVKALEIDVEEQVSRF-IELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
Query: 246 SVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVA 305
+ E D + + + Q V+ + + ++H +V++L + LK K ++ ++++
Sbjct: 2072 QAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCSELLLS 2131
Query: 306 VNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSN---------------V 350
E+ + + +++EI +++ +RE L+ A L D+ + +
Sbjct: 2132 ----KEQLQRDIQERNEEI---EKLEFRVRE-LEQALLVEDRKHFGAVEAKPELSLEVQL 2183
Query: 351 MALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQ 410
A + I ++ +I L EQ+EQ+ +E+E KNE QQ HM+++
Sbjct: 2184 QAERDAIDRKEKEITNLEEQLEQFREELEN--------KNE---------EVQQLHMQLE 2226
Query: 411 STLDILKEKTKEAERTAELAEADAREKD--KELVEALKRLKDYESGVYGLEDAVVEIKNC 468
+K + R EL + + KD ++L A+K ES +D V
Sbjct: 2227 I------QKKESTTRLQELEQENKLFKDDMEKLGLAIK-----ESDAMSTQDQHVLFGKF 2275
Query: 469 KNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQ 528
I+ ++ EI+ L +++ KL+ ++ +N+ + E+ L + + + +
Sbjct: 2276 AQIIQEKEVEIDQLNEQVTKLQQQLK-ITTDNKVIEEKNELIRDLETQIECLMSDQECVK 2334
Query: 529 QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588
+ E + L + IE L++E ++ +K A + A S D+ + E ++ +
Sbjct: 2335 RNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSE-EADSLKHQLDVVIAEKLALEQQ 2393
Query: 589 ISERKLDLLSLKN-MSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQL 647
+ ++ +KN + E K L++EL +R+ E + + +N + ++ +
Sbjct: 2394 VETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKD 2453
Query: 648 EEGMKEIL--QAIKEMQKDPDVK----GGETSLI-----IPSLERLVNA----------- 685
+ ++ +L A+K ++ K G+ S+I + LE V+A
Sbjct: 2454 KPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQ 2513
Query: 686 IESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL-RESRKEAINYSQQLAKANLKIDHLE 744
I+ +G F+ + K V+ E++ L + + EA+ + + N I
Sbjct: 2514 IKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEP 2573
Query: 745 KETSL-----LRQSE-GSNV---VFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKE 795
+ T++ LR+ E GS++ + +L + S+I + + I LE KE
Sbjct: 2574 ERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLE-KE 2632
Query: 796 KKLKNLEDSLEDYNRK------------FAVIRHQQSLLYKE----YLSEKETWKTESKT 839
KKL L+ LE +K V++ L + + +E E + ES
Sbjct: 2633 KKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVA 2692
Query: 840 IKEEKRKLEDQVQ--QDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
K E +++ + Q+ + VKE N + +LQ D +++ LAE K+++L+ +++ +
Sbjct: 2693 TKAELASYKEKAEKLQEELLVKETN--MTSLQKDLSQVRDHLAEAKEKLSILEKEDETEV 2750
Query: 898 RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSV 957
++ E K ++ ++ + + KI + ++ + K A +Q + +
Sbjct: 2751 QESKKACMFEPLPIKLSKS-----IASQTDGTLKISSSNQTPQILV-KNAGIQINLQSEC 2804
Query: 958 SLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEIT 1017
S E+ Q+ E K +++ + + +E +IS E E
Sbjct: 2805 SSEEVTEIISQFTEKIEKMQEL---------HAAEILDMESRHIS----------ETETL 2845
Query: 1018 KEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQ 1077
K + + Q ++E G ++ + +S S I ++ + + ++ Q
Sbjct: 2846 KREHYVAVQLLKEE--CGTLKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQ 2903
Query: 1078 KMY-EHLRTSLKQMEERNFELET---KFAELTKINLDAQKVEQMLRDELADSVSKAVSDA 1133
+Y H + E R E E+ F + K L A E M L +S D
Sbjct: 2904 GIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDH 2963
Query: 1134 DRQRILE--LEKNEMELKVEVSKLREISDI-----ARRQVEILNAQQQSRDKEVESLRMQ 1186
Q++ E LE E K ++ + + D+ +R+ E+ ++ Q +
Sbjct: 2964 SIQQVSEPWLE----ERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELL 3019
Query: 1187 LLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKE 1246
L Q +E+S++ + +E TALG +++ LEQ++ E +
Sbjct: 3020 LALQQVFLEERSVLLAAFR-------TELTALGTTDAV--------GLLNCLEQRIQE-Q 3063
Query: 1247 QALYYARLEGRNRA--KHLRQTIQSLRRQFSG-ALPLAQQEKFSKTMIQLQNDKLKIMQ- 1302
Y A +E +A + L IQ+L Q +G + L ++++ K +L ++ Q
Sbjct: 3064 GVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQS 3123
Query: 1303 EMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKV-INWHMKIEELRLQELKL 1361
+M Q E +M+++ E++ +L + +++ LK K+ + +K + L+EL+
Sbjct: 3124 QMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEA 3183
Query: 1362 NRELVKDK-EEIKYLNNIISEYERTIS----SLEEEIVQQNKFHEERQMAWDQREVDLER 1416
R VKDK +E+ LN+ ++ ++ +LE+E + + E + + + LE
Sbjct: 3184 FRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLES 3243
Query: 1417 ------QLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILET 1470
QL++ QQ ++LN +Q+ E+ + D L + L+ + E+ ++ +
Sbjct: 3244 QKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3303
Query: 1471 RATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPK 1530
++ E +L + L + R LP+ E L+ EL +K++E K
Sbjct: 3304 MSSTLDRERELHAQ-----------LQSSDGTGQSRPPLPS----EDLLKEL-QKQLEEK 3347
Query: 1531 SHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLE- 1589
+++ ++T L +++ ++K +++ K + ++E + ++ +H L ++E
Sbjct: 3348 HSRIVELLNETEKYKLDSLQTRQQ-MEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVED 3406
Query: 1590 LQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQ 1649
LQ + + DL Q + + E ++ E+++ S + + +++
Sbjct: 3407 LQRQLEEKRQQVYKLDLEGQRLQGI--------MQEFQKQELEREEKRESRRILYQNLNE 3458
Query: 1650 DLERQREITELKVKEF---ENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKS 1706
+T + + + + I+ + +E++ ++ ++ + L+ +++ QC+ S
Sbjct: 3459 --PTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVAS 3516
Query: 1707 ELQAQKEANSRAPTTTMRNLVERLKSQLALKEK---QQKALSRALLELRAEMTAAAEERI 1763
+LQ + S ERL+ + A E Q+ + +L+L+ EE
Sbjct: 3517 KLQVLPQKAS-----------ERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPS 3565
Query: 1764 I-----SATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALK----TSKNRENS 1814
+ S S E L + H +L + DL ++KL+E ++ T R+NS
Sbjct: 3566 LVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNS 3625
Query: 1815 LTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLI 1874
+LN N I EKE ++E L++ +KR + + SL+
Sbjct: 3626 SRFSLNGGAN-------IEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSLL 3678
Query: 1875 EEL 1877
+ L
Sbjct: 3679 QTL 3681
Score = 177 bits (450), Expect = 9e-44
Identities = 520/2691 (19%), Positives = 1103/2691 (40%), Gaps = 458/2691 (17%)
Query: 9 EIMKVDPDDLPRQEELADNLLISLSK--VEVNELKSEKQENVIHLFRITQSLMKMKAQEV 66
E+++ D +L + E+ + LS+ +++E +K + L +SL K + ++V
Sbjct: 932 EVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSL-KQEKEQV 990
Query: 67 ELALEEVEKA-GEEQAKFENQLKTKVMKL-ENELEMAQQSAGGRDTRFLRNEICQLEKQL 124
L E+E +A+ T+V L + + M + A G ++ N+ E ++
Sbjct: 991 SLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKV--NKSFGEESKI 1048
Query: 125 EQKDR-ELEDME--KELEKEKKVNEQLALRNEEAE------NENSKLRRE---------N 166
+D+ E+M +E ++E+ + + L +E+ +EN KL++E +
Sbjct: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQND 1108
Query: 167 KRLKKKNEQLCQDII------DYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLD 220
RL+ + +++C ++ ++ ++++K+ L E+ + + K + I L
Sbjct: 1109 LRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQL- 1167
Query: 221 EIQTLT-----EANEKIEVQNQEMRKNLEES----VQEMEKMTDEYNR--MKAIVHQTD- 268
E+QT+ + + + + +++K + E +Q + + EY +K V+ D
Sbjct: 1168 ELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK 1227
Query: 269 -NVIDQLKKEND----HYQLQVQELTD----LLKSKNEEDDPIMVAVNA----------- 308
N D + + D Y+ +VQ+ + LL EE + ++V
Sbjct: 1228 ENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDG 1287
Query: 309 -KVEEWKLILSSKDDEIIEYQQMLHNLRE-------KLKNAQLDADKSNVMALQQGIQER 360
K+E + L ++ E + + NL + KL + Q D +K+ L++ +QE
Sbjct: 1288 MKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQ-DLEKTK---LEEQVQEL 1343
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT 420
+S I L +Q+++ + E I L+ LQ +S+ T + +D +
Sbjct: 1344 ESLISSLQQQLKETEQNYEAE---IHCLQKRLQ------AVSEST-VPPSLPVDSVVITE 1393
Query: 421 KEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIE 480
+A+RT + D + SG +G+++ +K + Q + E
Sbjct: 1394 SDAQRTMYPGSCVKKNIDGTIEF---------SGEFGVKEETNIVKLLEKQYQ------E 1438
Query: 481 ILTKEINKLELKIS-DFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILL 539
L +E+ K+ + +S F + E R G E + + + + QQ+ N++ L
Sbjct: 1439 QLEEEVAKVIVSMSIAFAQQTELSRISGGKE-----NTASSKQAHAVCQQEQHYFNEMKL 1493
Query: 540 KE----IESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLN-LTENISQGDRISERKL 594
+ ++ E + K++ + +++E G+ L+ D + + E+ ISE
Sbjct: 1494 SQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMF 1553
Query: 595 DLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEI 654
K QS ++ +S ++ R L + + + +L +E++Q E +++
Sbjct: 1554 S--KDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQA 1611
Query: 655 LQAIKEMQKDPDVKGGETSLIIPSLERLV---NAIESKNA----EGIFDASLHLKAQVDQ 707
E Q++ + E I L R + ++I+++N E + L Q+
Sbjct: 1612 HMRQMERQREDQEQLQEE---IKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLS- 1667
Query: 708 LTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPD 767
L GR E+L ELR S + N ++ + + KE L R+ E D+P
Sbjct: 1668 LAGR-EKLCCELRNSSTQTQNGNENQGEVE---EQTFKEKELDRKPE---------DVPP 1714
Query: 768 GIAPSSASIINSQNEYLIHLLQELENKEKKLKN---------LEDSLEDYNRKFAVIRHQ 818
I + + N L+ +L E+ ++ L+ S + + + R +
Sbjct: 1715 EILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLGILDRSSKSQSSASLIWRSE 1774
Query: 819 QSLLYKEYLSEKETWKTESKT------------------IKEEKRKLEDQVQQDAIKVKE 860
K + E+ T T+ + EE +L ++ + E
Sbjct: 1775 AEASVKSCVHEEHTRVTDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTE 1834
Query: 861 YN--------NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRK 912
+ N+ + LQ +++ + ++E S ++ +V + L+R+ R+
Sbjct: 1835 IDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRE---------SFRQ 1885
Query: 913 ENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNEL 972
+ E E L + E+ E++ R +E +++ + V+D E L +Q E
Sbjct: 1886 KQEA--TESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYAD--EKTLFERQIQEK 1941
Query: 973 TAKYRDILQK-DNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQE 1031
T DI+ + + L+ ++ L+ LE E ++E+ E ++++ E K + +EQ QE
Sbjct: 1942 T----DIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQE 1997
Query: 1032 T-KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQM 1090
T KL E + + D+ K++ LE ++ ++ ++ + T L +
Sbjct: 1998 TEKLMKEKLEVQCQAEKVRDDL---QKQVKALE---IDVEEQVSRFIELEQEKNTELMDL 2051
Query: 1091 EERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKV 1150
++N LE + ++ K LD Q ++ R+ D + E++K E +LKV
Sbjct: 2052 RQQNQALEKQLEKMRKF-LDEQAID---REHERDVFQQ-----------EIQKLEQQLKV 2096
Query: 1151 EVSKLREISDIARRQVE----------------ILNAQQQSRDKEVESLRMQLLDYQAQS 1194
V + + IS+ R+VE +L+ +Q RD + + ++ L+++ +
Sbjct: 2097 -VPRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRE 2155
Query: 1195 DEKSLIAKLHQHNVSLQLSEATALG-KLESITSKLQKMEAYNLRLEQKLDEKEQALYYAR 1253
E++L+ + +H +++ +L +L++ + + E LE++L++ +
Sbjct: 2156 LEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQ-----FREE 2210
Query: 1254 LEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRN 1313
LE +N + +Q L Q L Q+K S T +Q +QE++
Sbjct: 2211 LENKN------EEVQQLHMQ------LEIQKKESTTRLQ-------------ELEQENKL 2245
Query: 1314 MENKTLEMELKLKGLEELISTLKDT---KGAQKVINWHMKIEELRLQELKLNREL--VKD 1368
++ ++ L +K + + + + K AQ + ++I++L Q KL ++L D
Sbjct: 2246 FKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTD 2305
Query: 1369 KEEIKYLNNIISEYERTISSL--EEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQN 1426
+ I+ N +I + E I L ++E V++N RE ++E+ ++ ++ Q
Sbjct: 2306 NKVIEEKNELIRDLETQIECLMSDQECVKRN------------REEEIEQLNEVIEKLQQ 2353
Query: 1427 EILNAAQKFEEATGSIPDPSLPLPNQLEIALRK---IKENIR-----------IILETRA 1472
E+ N QK S+ + + L +QL++ + + +++ + ++ ET
Sbjct: 2354 ELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNF 2413
Query: 1473 TCKSLEEKL----KEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEME 1528
L ++L +E+ES ++ S + I+ L P E E ++ E K +E
Sbjct: 2414 KMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKP---ELEVVLTEDALKSLE 2470
Query: 1529 PKSHHTL--KIAHQTIANMQARLNQKEEVL-----------KKYQRLLEKAREEQREIVK 1575
+++ + +I N++ RL Q E + K+ + + E+ + E + K
Sbjct: 2471 NQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2530
Query: 1576 K--------HEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEME 1627
K E+ L +++L+A KF Q + + N + +R E+
Sbjct: 2531 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELG 2590
Query: 1628 QTVAEQDDSLSSLLVKLKKVSQDL---ERQREITELKVKEFENIKLQLQE--------NH 1676
++ +S L ++ ++ L + Q EI E V E E L+LQ+
Sbjct: 2591 SDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQR 2650
Query: 1677 EDEVKKVKAEVEDLKYLLD--QSQKESQCLKSELQAQKEAN--SRAPTTTMRNLVERLKS 1732
E E K+ +VE LK + S +ES +EL+A + + ++A + + E+L+
Sbjct: 2651 EKEKKRSPQDVEVLKTTTELFHSNEESGFF-NELEALRAESVATKAELASYKEKAEKLQE 2709
Query: 1733 QLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQ-----IVDRHTREL 1787
+L +KE +L + L ++R + A E+ I +KE VQ+ + + +L
Sbjct: 2710 ELLVKETNMTSLQKDLSQVRDHLAEAKEKLSIL---EKEDETEVQESKKACMFEPLPIKL 2766
Query: 1788 KTQVEDLNENLLKLKEALKT---------------SKNRENSLTDNLNDLNNELQKKQKA 1832
+ + LK+ + +T S+ +T+ ++ +++K Q+
Sbjct: 2767 SKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQE- 2825
Query: 1833 YNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKV 1892
L E +D E+ + L + ++ + + ++ E ++
Sbjct: 2826 ----LHAAEILDMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPEL 2881
Query: 1893 EEVDLKPMKEKNAKEELIRWEEG------KKWQAKIEGIRNKLKEKEGEVFTLTKQLNTL 1946
D +E + + W +G + + EG + +E E + K++ L
Sbjct: 2882 AHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEG---RGEESESATDSFPKKIKGL 2938
Query: 1947 KDLFAKADKEKLTLQRKLKTTGM--TVDQVLGIRALESEKELEELKKRNLDLENDILYMR 2004
+ L+L + G ++ QV SE LEE +K ++ + + +
Sbjct: 2939 LRAVHNEGMQVLSLTESPYSDGEDHSIQQV-------SEPWLEE-RKAYINTISSLKDLI 2990
Query: 2005 AHQALPRDSVVEDLHLQNRYLQ----EKLHALEKQFSKD-----TYSKPSISGIESDDHC 2055
L R++ V D + E L AL++ F ++ + ++ + + D
Sbjct: 2991 TKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAV 3050
Query: 2056 QREQELQKENLKLSSENIELKFQLEQANK-DLPRLKNQVRDLKEMCEFLKKEKAEVQRKL 2114
L++ ++ + +E + +E K D L ++++ L
Sbjct: 3051 GLLNCLEQ---RIQEQGVEYQAAMECLQKADRRSLLSEIQAL------------------ 3089
Query: 2115 GHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTS--EKMANIEQENEK 2172
H + +GR E E + + +Q++ Q+ + L+S ++ ++++
Sbjct: 3090 -HAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQLSS 3148
Query: 2173 LKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEI 2232
K + +LK+ L Q + E+ K K + E E R E+K +TD + +
Sbjct: 3149 EKMVVAELKSELA-QTKLELETTLKAQHKHLKELEAFRLEVKDKTD----------EVHL 3197
Query: 2233 LNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQS 2292
LN+ + + ++ + LQ+A LE +K +S + +L++L+ + + Q
Sbjct: 3198 LNDTLASE-QKKSRELQWA------LEKEKAKLGRS---EERDKEELEDLKFSLESQKQR 3247
Query: 2293 ITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVL-------- 2344
L L++ +++Q +N+ + +E Q + EQG ELQVL
Sbjct: 3248 NLQLNLLLE---QQKQLLNESQQKIESQRML---YDAQLSEEQGRNLELQVLLESEKVRI 3301
Query: 2345 RLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQ-LKMSDL--EKQH 2401
R + LD+E+ EL Q++++ + +P D LKE K LE + ++ +L E +
Sbjct: 3302 REMSSTLDRER-ELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEK 3360
Query: 2402 LKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQL 2452
K + + ++++E + ++ + E KK L+ KV+ L QL
Sbjct: 3361 YKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQL 3411
Score = 177 bits (449), Expect = 1e-43
Identities = 457/2449 (18%), Positives = 1010/2449 (41%), Gaps = 346/2449 (14%)
Query: 27 NLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQ------EVELALEEVEKAGEEQ 80
N+ I+ +++ + S+K++ L I + ++ Q E+ + E++++A +
Sbjct: 492 NVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTI 551
Query: 81 AKFENQLK------TKVMKLENELEMAQQSAGGRDTRF---LRNEICQLEKQLEQKDREL 131
A+ E++L + V L+ E+ A +S + + + N +LE ++K+ L
Sbjct: 552 AEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVL 611
Query: 132 EDMEKELEKE-KKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDI--IDYQKQID 188
+ M + E E +++ QL +EE E SKL+ + + + N + +D I Y++QID
Sbjct: 612 DRMAESQEAELERLRTQLLFSHEE---ELSKLKEDLEIEHRINIEKLKDNLGIHYKQQID 668
Query: 189 S--------------QKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTL--TEANEKI 232
+K+ L++++ + S+L L+ E TL E ++I
Sbjct: 669 GLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEI 728
Query: 233 EVQNQEMRKN--LEESVQEMEKMTDEYNR-MKAIVHQTDNVIDQLKKENDHYQLQVQELT 289
E+ QE ++ LE+ VQE++ T+ + MK + QL+ EN + + + L
Sbjct: 729 EILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE 788
Query: 290 DLLKS----KNEEDDPIMVAVNAKVEE--WKL---ILSSKDDEIIEYQQMLHNLREKLKN 340
D+LK EE + ++ +K ++ W+ IL +++++ + L+ EK +N
Sbjct: 789 DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRN 848
Query: 341 AQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRN----- 395
A+K+ + Q+ +E +K+ + + K+ + ++ L EL
Sbjct: 849 TFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPT 908
Query: 396 --KGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREK---DKELVEALKRLKD 450
K S++ + + TL++ + K+ E E REK + L + ++LK
Sbjct: 909 TVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ 968
Query: 451 YESGVYGLEDAVVEIKNCKNQIKIRDREIEIL-----TKEINKLELKISDFLDENEALRE 505
+ L + V +K K Q+ +R RE+EI+ + + + ++S LD +
Sbjct: 969 KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTS 1028
Query: 506 RVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGK 565
R + ++ + SK + + + EN + +E + E+ LD + + + R
Sbjct: 1029 RGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQ-EQLILDHLPSVTKESSLRAT 1087
Query: 566 RSATSGLTTEDLNLTENISQGDRIS-ERKLDLLSLKNMSEAQSKNEF-----------LS 613
+ + + ++LN+ ++ R+ E + LSL + E+ L
Sbjct: 1088 QPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLK 1147
Query: 614 RELI----EKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKE-----MQKD 664
ELI EK ++L++ + + K +E +E K L + ++ +A+ E +Q
Sbjct: 1148 EELIFAQEEKIKELQKIHQLELQTM-KTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTL 1206
Query: 665 PDVKGGETSLIIPSLERLVNAIESKNAEGIF----DASLH-LKAQVDQLTGRNEELRQEL 719
V G P+L+ VNA + +N+ D L + +V L ++
Sbjct: 1207 CSVLG---EYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNKV 1263
Query: 720 RESRKEAINYSQQLAKA------NLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSS 773
E + + +L+K +K++ E E ++E ++ + +L D
Sbjct: 1264 TEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE-ENLPKEETEFLSIHSQMTNLEDIDVNHK 1322
Query: 774 ASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRH--QQSLLYKEYLSEKE 831
+ + + Q+ L ++++ E + +L+ L++ + + H Q+ L +
Sbjct: 1323 SKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPP 1382
Query: 832 TWKTESKTIKEE------------KRKLEDQVQ-QDAIKVKEYNNLLNALQMD-----SD 873
+ +S I E K+ ++ ++ VKE N++ L+ +
Sbjct: 1383 SLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEE 1442
Query: 874 EMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIG 933
E+ K++ S I Q E S I +Q +++++ M+ ++IG
Sbjct: 1443 EVAKVIV--SMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQ-DQIG 1499
Query: 934 CLQRFKEMAI-FKIAALQKVVDNSVSLSELELANKQYNELTAKY-------RDILQKDNM 985
Q F+ + + FK + E+ L+N +++ ++ KD
Sbjct: 1500 -FQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKT 1558
Query: 986 LVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKK 1045
+ R S + + ++ Q+ ++LE +++L Q +Q T+L ++ M + ++
Sbjct: 1559 FIVRQSIHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMER 1618
Query: 1046 SITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE------------- 1092
D + ++I L ++L +R ++ + E R L+++E
Sbjct: 1619 Q--REDQEQLQEEIKRLN-RQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLC 1675
Query: 1093 ---RNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELK 1149
RN +T+ + ++ Q ++ D + V + +R + + +++
Sbjct: 1676 CELRNSSTQTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKIL 1735
Query: 1150 VEVSKLREISD--IARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHN 1207
+EV K + I R + IL+ +S +S + +A++ KS + + H
Sbjct: 1736 LEVVKTTAAVEETIGRHVLGILDRSSKS-----QSSASLIWRSEAEASVKSCVHEEHTRV 1790
Query: 1208 VSLQLSEATALGKLESITSKLQKMEAYNLRLEQKL-----------DEKEQALYYARLEG 1256
+ + + + K+ L Q+L E E+ +
Sbjct: 1791 TDESIPSYSGSDMPRNDINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRL 1850
Query: 1257 RNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQN--DKLKIMQEMKNSQQEHRNM 1314
+ + L + I Q A + Q E ++ Q Q + LK +E++ E
Sbjct: 1851 QAAVEKLLEAISETSSQLEHA-KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRA 1909
Query: 1315 ENKTLEMELKLKGLEELISTLKDTKGA----------------QKVINWHMKIEELRLQE 1358
++ ++L E +I D K Q+++ +++EL ++
Sbjct: 1910 RE---QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQ 1966
Query: 1359 LKLNRE---LVKDKEEIK-----YLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQR 1410
++ E L + KE +K ++ E E+ + E Q K ++ Q
Sbjct: 1967 QQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKAL 2026
Query: 1411 EVDLERQLDIFD-------------RQQNEILNAAQKFEEATGSIPDPSLPLPNQLEI-- 1455
E+D+E Q+ F RQQN+ L ++ E+ + + ++ ++ ++
Sbjct: 2027 EIDVEEQVSRFIELEQEKNTELMDLRQQNQALE--KQLEKMRKFLDEQAIDREHERDVFQ 2084
Query: 1456 -ALRKIKENIRIIL--------ETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELR 1506
++K+++ ++++ +TR + L LKEK + +LS++++ +++
Sbjct: 2085 QEIQKLEQQLKVVPRFQPISEHQTREV-EQLANHLKEKTDK---CSELLLSKEQLQRDIQ 2140
Query: 1507 LRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRL---L 1563
R + E + EL + + H + + +++ +L + + + + ++ L
Sbjct: 2141 ERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNL 2200
Query: 1564 EKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRL 1623
E+ E+ RE ++ E++ LH +LE+Q S + ++ + NK F
Sbjct: 2201 EEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQELEQE-----------NKLFKDD 2249
Query: 1624 AEMEQTVAEQDDSLSS-----LLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHED 1678
E ++ D++S+ L K ++ Q E++ EI +L ++ ++ QL+ ++
Sbjct: 2250 MEKLGLAIKESDAMSTQDQHVLFGKFAQIIQ--EKEVEIDQLN-EQVTKLQQQLKITTDN 2306
Query: 1679 EVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738
+V +E+ L+ + + +CL S+ + K RN +E
Sbjct: 2307 KV------IEEKNELIRDLETQIECLMSDQECVK-----------RN-----------RE 2338
Query: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRE---LKTQVEDLN 1795
++ + L+ + +L+ E+ ++ ++A S E +++ +D E L+ QVE N
Sbjct: 2339 EEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETAN 2398
Query: 1796 ENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAY----NKILREKEEIDQENDEL- 1850
E + +K LK + + N LT L L E + +K N + + + ++ EL
Sbjct: 2399 EEMTFMKNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELE 2458
Query: 1851 ----KRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAK 1906
+ +K L + K +N + I L+ ++ +LE+ + K E+ + K+ +
Sbjct: 2459 VVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQ 2518
Query: 1907 EELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKT 1966
E+ E + Q KI ++ ++EK QL +++ +AK ++ T+ + +
Sbjct: 2519 EQ--GQFETEMLQKKIVNLQKIVEEKVAAALVSQIQLEAVQE-YAKFCQDNQTISSEPER 2575
Query: 1967 TGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSV-VEDLHLQNRYL 2025
T + + +R E ++ L R +LE+ ++ M L ++ V + + ++ +
Sbjct: 2576 T--NIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEK-- 2631
Query: 2026 QEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQK-----ENLKLSSE----NIELK 2076
++KL L+K +E ++ QRE+E ++ E LK ++E N E
Sbjct: 2632 EKKLLELQKL-------------LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESG 2678
Query: 2077 F--QLEQANKDLPRLKNQVRDLKEMCEFLKKE-------KAEVQRKLGHVRGSGRSGKTI 2127
F +LE + K ++ KE E L++E +Q+ L VR +
Sbjct: 2679 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDH------L 2732
Query: 2128 PELEKTIGLMKKVVEKVQRENEQ--LKKASGILTSEKMANIEQENEKLKAELEK---LKA 2182
E ++ + +++K E +E+++ + + I S+ +A+ K+ + + L
Sbjct: 2733 AEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVK 2792
Query: 2183 HLGHQLSMHYESKTKGTEKIIAE-NERLRKELKKETDAAEKLRIAKNNL 2230
+ G Q+++ E ++ +II++ E++ K +E AAE L + ++
Sbjct: 2793 NAGIQINLQSECSSEEVTEIISQFTEKIEK--MQELHAAEILDMESRHI 2839
Score = 172 bits (436), Expect = 4e-42
Identities = 461/2269 (20%), Positives = 930/2269 (40%), Gaps = 355/2269 (15%)
Query: 84 ENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKK 143
E QL+ +L + + QQ+ T LR + + Q +R+ ED E+ E+ K+
Sbjct: 1584 EEQLEDMRQELVRQYQEHQQA-----TELLR------QAHMRQMERQREDQEQLQEEIKR 1632
Query: 144 VNEQLALRNEEAENENSKLRRENKRLKK----------KNEQLC----------QDIIDY 183
+N QLA R+ +NEN RE L++ E+LC Q+ +
Sbjct: 1633 LNRQLAQRS-SIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNEN 1691
Query: 184 QKQIDSQ--KETLLSRRGED------SDYRSQLSKKNYELIQYLDEIQTLTEANEKI--- 232
Q +++ Q KE L R+ ED S+ R L K N L++ L E+ T A E+
Sbjct: 1692 QGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGR 1751
Query: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLL 292
V R + +S + ++ +K+ VH+ +H ++ + +
Sbjct: 1752 HVLGILDRSSKSQSSASLIWRSEAEASVKSCVHE------------EHTRVTDESIPSYS 1799
Query: 293 KSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMA 352
S +D + W S +E E Q L +R ++D + +M
Sbjct: 1800 GSDMPRND---------INMW----SKVTEEGTELSQRL--VRSGFAGTEIDPENEELML 1844
Query: 353 LQQGIQER-DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411
I R + ++ L E + + + ++E +L E R K +T
Sbjct: 1845 ---NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEAT----------- 1890
Query: 412 TLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQ 471
E K E E ++R +++ VE K G+ D + K
Sbjct: 1891 ------ESLKCQEELRERLHEESRAREQLAVELSK--------AEGVIDGYADEKT---- 1932
Query: 472 IKIRDREIEILTKEINKLELKI---SDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQ 528
+ +R+I+ T I++LE ++ S+ L E EA ++++ E + + R + +K
Sbjct: 1933 --LFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELL-----SRQKEAMKA 1985
Query: 529 QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588
+ E Q LL+E E L +E+L+++ + ++ + K+ + ++++ E +S+
Sbjct: 1986 EAGPVEQQ-LLQETEKLMKEKLEVQCQAEKVRDDLQKQ-----VKALEIDVEEQVSRFIE 2039
Query: 589 I-SERKLDLLSLKNMSEAQSK-----NEFLSRELIEKERD----------LERSRTVIAK 632
+ E+ +L+ L+ ++A K +FL + I++E + LE+ V+ +
Sbjct: 2040 LEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPR 2099
Query: 633 FQ-------NKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNA 685
FQ ++++L K+ + E+L + +++Q+D + E + + L A
Sbjct: 2100 FQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQA 2159
Query: 686 --IESKNAEGIFDA------SLHLKAQVDQLTGRNEE---LRQELRESRKEAINYSQQLA 734
+E + G +A + L+A+ D + + +E L ++L + R+E N ++++
Sbjct: 2160 LLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQ 2219
Query: 735 KANLKIDHLEKE-TSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLI--HLLQEL 791
+ +++++ +KE T+ L++ E N +FK G+A + +++Q+++++ Q +
Sbjct: 2220 QLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQII 2279
Query: 792 ENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEE--KRKLED 849
+ KE ++ L + + ++ + + + K L + E +E KR E+
Sbjct: 2280 QEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREE 2339
Query: 850 QVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLV----E 905
+++Q N ++ LQ E+ I + S L SL Q ++
Sbjct: 2340 EIEQ-------LNEVIEKLQ---QELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2389
Query: 906 LERQLRKENEK---QKNELLSME---AEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSL 959
LE+Q+ NE+ KN L ++ +++ L+R +E + +Q + +NSV++
Sbjct: 2390 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE----SVEKIQSIPENSVNV 2445
Query: 960 SELELANKQYNELTAKYRDILQK-DNMLVQRT------SNLEHLECENISLKEQVESINK 1012
+ L+ + D L+ +N ++ ++ +LE + L+ V + +
Sbjct: 2446 AIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEENGKGSIINLETRLLQLESTVSAKDL 2505
Query: 1013 ELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQR 1072
EL +++ +++ + ET++ KK + IV ++ +L Q
Sbjct: 2506 ELTQCYKQIKDMQEQGQFETEM-------LQKKIVNLQKIVEEKVAAALVSQIQLEAVQE 2558
Query: 1073 -AEHCQK----MYEHLRTSLKQMEE-RNFELETKFAELTK--INLDAQKVEQMLRDELAD 1124
A+ CQ E RT+++ + + R EL + + LT L++Q VE +
Sbjct: 2559 YAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEM----HTSL 2614
Query: 1125 SVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLR 1184
+ K + + +LE EK +EL+ KL E ++ +R+ E ++ +D EV
Sbjct: 2615 ILEKEQVEIAEKNVLEKEKKLLELQ----KLLEGNEKKQREKE---KKRSPQDVEVLKTT 2667
Query: 1185 MQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDE 1244
+L +S + + L +V+ + A+ K E + +L E L++ L +
Sbjct: 2668 TELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQ 2727
Query: 1245 KEQALYYARLEGRNRAKHLRQTIQSLRRQ-FSGALPLAQQEKFSKTMIQLQNDKLKIMQE 1303
L A+ + K +Q ++ LP+ K SK++ + LKI
Sbjct: 2728 VRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPI----KLSKSIASQTDGTLKISSS 2783
Query: 1304 MKNSQQEHRNMENK-TLEMELKLKGLEELISTLKDTKGAQKVINWH----MKIEELRLQE 1358
+ Q +N + L+ E + + E+IS T+ +K+ H + +E + E
Sbjct: 2784 NQTPQILVKNAGIQINLQSECSSEEVTEIISQF--TEKIEKMQELHAAEILDMESRHISE 2841
Query: 1359 LK-LNRE----LVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVD 1413
+ L RE + KEE L +I S E+ + + + R++ D
Sbjct: 2842 TETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAY-QTREICSSDSGSD 2900
Query: 1414 LERQLDIFDRQQNEILN--AAQKFEEATGSIPDPSLPLPNQLEIALRKI-KENIRIILET 1470
+ + + Q +I + ++ E AT S P +++ LR + E ++++ T
Sbjct: 2901 WGQGIYLTHSQGFDIASEGRGEESESATDS-------FPKKIKGLLRAVHNEGMQVLSLT 2953
Query: 1471 RATCKSLEEKLKEKESALRLAEQ-----NILSRDKVINELRLRLPATAE----------- 1514
+ E+ ++ S L E+ I S +I +++L+ A
Sbjct: 2954 ESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSD 3013
Query: 1515 -REKLIAELGRKEMEPKSHHTLKIAHQT------IANMQARLNQKEEVLK----KYQRLL 1563
R +L+ L + +E +S L A +T + LN E+ ++ +YQ +
Sbjct: 3014 WRGELLLALQQVFLEERS--VLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAAM 3071
Query: 1564 EKAREEQREIVKKHEEDLH--ILHHRLELQADSSLNKFKQTAWDL---MKQS---PTPVP 1615
E ++ R + + LH + ++ L+ + K Q + KQS V
Sbjct: 3072 ECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVE 3131
Query: 1616 TNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQEN 1675
+ R E+++ ++ + ++ L +L + +LE + +KE E +L
Sbjct: 3132 LSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRL----- 3186
Query: 1676 HEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLA 1735
EVK EV L L QK+S+ L+ L+ +K R+ L E LK L
Sbjct: 3187 ---EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEEL-EDLKFSLE 3242
Query: 1736 LKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTREL----KTQV 1791
+KQ+ LLE + ++ ++++I S +A L+ +Q + + L K ++
Sbjct: 3243 -SQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRI 3301
Query: 1792 EDLNENLLKLKE---ALKTSKNRENS-----LTDNLNDLNNELQKKQKAYNKILREKEEI 1843
+++ L + +E L++S S D L +L +L++K ++L E E+
Sbjct: 3302 REMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKY 3361
Query: 1844 ------DQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV-- 1895
++ E RQ+ R T + + T+ Q + ELQ KV+ L+ QLE K ++V
Sbjct: 3362 KLDSLQTRQQMEKDRQVHRKTLQTEQEANTEG-QKKMHELQSKVEDLQRQLEEKRQQVYK 3420
Query: 1896 -DLKPMKEKNAKEELIRWE---EGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFA 1951
DL+ + + +E + E E K+ +I + L E T + N +
Sbjct: 3421 LDLEGQRLQGIMQEFQKQELEREEKRESRRI--LYQNLNEPTTWSLTSDRTRNWVL---- 3474
Query: 1952 KADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPR 2011
++K+ + K ++ G E E+ K + + + +L +A + L
Sbjct: 3475 ---QQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQF 3531
Query: 2012 DSVVEDLHLQNRYLQEKLHALEKQFSKDT---YSKPSISGIESDDHCQREQELQKENLKL 2068
++ ++ + ++QE + + Q K T +PS+ + C E +L
Sbjct: 3532 ETADDEDFI---WVQENIDEIILQLQKLTGQQGEEPSL--VSPSTSCGSLTE------RL 3580
Query: 2069 SSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIP 2128
+N EL + Q ++ L+N V L+E + ++ G+GR +
Sbjct: 3581 LRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQ------------TGAGRDNSSRF 3628
Query: 2129 ELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAEL 2177
L +E + +++ + + + E E KLKAEL
Sbjct: 3629 SLNGGAN-----IEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAEL 3672
Score = 75.1 bits (183), Expect = 8e-13
Identities = 147/697 (21%), Positives = 293/697 (42%), Gaps = 91/697 (13%)
Query: 243 LEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPI 302
LE+ +QE EY + + D + + H Q+ +++T LK + E + P
Sbjct: 3056 LEQRIQEQGV---EYQAAMECLQKADRRSLLSEIQALHAQMNGRKIT--LKREQESEKPS 3110
Query: 303 MVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQ--LDADKSNVMALQQGIQER 360
+ +++ K +++E Q L +++++ Q L ++K V L+ + +
Sbjct: 3111 QELLEYNIQQ-------KQSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQT 3163
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKT 420
+++ + ++ KE+E ++D +E+ Q+ ++Q L+ KEK
Sbjct: 3164 KLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALE--KEKA 3221
Query: 421 KEAERTAELAEADAREKDKELVEALK-RLKDYESGVYGLEDAVVEIKNCKN--QIKIRDR 477
K + E+DKE +E LK L+ + L + + K N Q KI +
Sbjct: 3222 KLGR---------SEERDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQ 3272
Query: 478 EI----EILTKEINKLELKISDFLDENEALRERVGLEPKTMIDL-----TEFRNSKHLKQ 528
+ ++ ++ LEL++ L E+E +R R E + +D + ++S Q
Sbjct: 3273 RMLYDAQLSEEQGRNLELQV---LLESEKVRIR---EMSSTLDRERELHAQLQSSDGTGQ 3326
Query: 529 QQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDR 588
+ ++ LLKE++ EE+ +I ++ E K S T + + + +
Sbjct: 3327 SRPPLPSEDLLKELQKQLEEK---HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTL 3383
Query: 589 ISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLE 648
+E++ + K M E QSK E L R+L EK + + + + Q ++E ++ + E
Sbjct: 3384 QTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQEFQKQELERE 3443
Query: 649 EGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLK--AQVD 706
E +E + + + +P T+ + S +R N + + EG S + K
Sbjct: 3444 E-KRESRRILYQNLNEP------TTWSLTS-DRTRNWVLQQKIEGETKESNYAKLIEMNG 3495
Query: 707 QLTGRNEEL---RQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGI 763
TG N EL RQ+L + + Q A L+ + + E + Q ++ +
Sbjct: 3496 GGTGCNHELEMIRQKL-QCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQ 3554
Query: 764 DL-------PDGIAPSSA-----SIINSQNEYLIHLLQELENKEKKLKNLEDSLED---Y 808
L P ++PS++ + QN L + +L ++ L+N+ LE+ +
Sbjct: 3555 KLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRW 3614
Query: 809 NRKFAVIRHQQSL--------LYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKE 860
R+ R S + SEKE W E T+++ ++ E +V + +++
Sbjct: 3615 YRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREKLTLQKSLKRAEAEVYKLKAELRN 3674
Query: 861 YNNLLNALQMDSDEM-------KKILAENSRKITVLQ 890
++LL L DS+ + K + AE+ RK + Q
Sbjct: 3675 -DSLLQTLSPDSEHVTLKRIYGKYLRAESFRKALIYQ 3710
Score = 50.1 bits (118), Expect = 3e-05
Identities = 76/388 (19%), Positives = 173/388 (44%), Gaps = 50/388 (12%)
Query: 2106 EKAEVQRKLGHVRGS-GRSG-KTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKM 2163
E E+ R+L +R + G G + + E E I ++ ++ +Q ++ T +
Sbjct: 170 EIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDE-TMREF 228
Query: 2164 ANIEQENEKLKAELEKLKAHLGHQLSMHYESKT---KGTEKIIAENERLRKELKKETDAA 2220
+ ++++KL+ + ++L+A + S H + + ++I+ ++L ++ D
Sbjct: 229 LELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQ 288
Query: 2221 EKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLK 2280
+K + L EK+ V E K+++ + Q + ET ++
Sbjct: 289 KKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK----------------ETIIE 332
Query: 2281 ELETDIAKKNQSITDLKQLVKEATE-----REQKVNKYNEDLEQQIKILKHVPEGAETEQ 2335
EL T I ++ + +LK + A + +EQ V K E ++++ + ++ +
Sbjct: 333 ELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSE 392
Query: 2336 GLKR---ELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQL 2392
+K+ ++ L+ NH+ + + +++ ++E + T +QL+ ++ ++ Q
Sbjct: 393 EIKQLMGTVEELQKRNHKDSQFETDIVQRME--------QETQRKLEQLRAELDEMYGQQ 444
Query: 2393 KMS---DLEKQHLK--EEIK-KLKKELENFDPSFFE---EIEDLKYNYKEEVKKNILLEE 2443
+ +L +QH+ EE+K + K E+EN S+ + +K + NI L++
Sbjct: 445 IVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQD 504
Query: 2444 ---KVKKLSEQLGVELTSPVAASEEFED 2468
+ +KL E+LG+ L A + ED
Sbjct: 505 TNSQKEKLKEELGLILEEKCALQRQLED 532
Score = 37.0 bits (84), Expect = 0.24
Identities = 40/158 (25%), Positives = 66/158 (41%), Gaps = 17/158 (10%)
Query: 14 DPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEV 73
D +D +E D +++ L K+ + E+ V ++ Q EL +
Sbjct: 3535 DDEDFIWVQENIDEIILQLQKLTGQQ--GEEPSLVSPSTSCGSLTERLLRQNAELT-GHI 3591
Query: 74 EKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRD--TRFLRNEICQLEKQLEQKDREL 131
+ EE+ N L+ VMKLE ++ +Q+ GRD +RF N +E +
Sbjct: 3592 SQLTEEK----NDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIAS----- 3642
Query: 132 EDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRL 169
EKE+ +K+ Q +L+ EAE K N L
Sbjct: 3643 ---EKEVWNREKLTLQKSLKRAEAEVYKLKAELRNDSL 3677
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 193 bits (491), Expect = 2e-48
Identities = 349/1795 (19%), Positives = 726/1795 (40%), Gaps = 239/1795 (13%)
Query: 32 LSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKV 91
L + E+N+L Q + QS E++ KF+ + + +
Sbjct: 9 LERTELNKLPKSVQNKLEKFLADQQS--------------EIDGLKGRHEKFKVESEQQY 54
Query: 92 MKLENELEMAQQSAGG--RDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLA 149
++E L +Q+ R+ + LR E+ +L QL+ + +++E ++ + Q
Sbjct: 55 FEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFT 114
Query: 150 LRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKET-----LLSRRGEDSDY 204
EE E E L R N+RL ++ E L +D+ +++ T L + SD
Sbjct: 115 RTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDV 174
Query: 205 RSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIV 264
+ +K E + L Q T N +++ + E+ E E+ ++ K V
Sbjct: 175 SVKYREKRLEQEKELLHSQN-TWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEV 233
Query: 265 HQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEE----DDPIMVAVNAKVEEWKLILSSK 320
+ + ++ LK N+H Q V++L LK E+ ++ +NA ++ L S+
Sbjct: 234 SRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAA 293
Query: 321 DDEIIEYQQMLHNLRE--KLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEM 378
DD + ++ + E KL +A+K+ L + Q +D K + E++ + KE+
Sbjct: 294 DDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKEL 353
Query: 379 EKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKD 438
E ++ K KGA LS++ + T + + K + EL A +D
Sbjct: 354 ENANDLLSATK-----RKGA-ILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQD 407
Query: 439 KELVEAL--KRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDF 496
+ L+E L KR+ Y L++ V E++ +K + E E K + L +K+
Sbjct: 408 QLLLEKLENKRINKY------LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQA 461
Query: 497 LDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKI 556
+ E + L+E K ++ +L ++ +E + DL ++I
Sbjct: 462 MKEIQRLQEDTDKANK---------------------QSSVLERDNRRMEIQVKDLSQQI 500
Query: 557 RQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFL---S 613
R + E + + E+++ + S + IS+ L+S +N+ E Q +N+ L
Sbjct: 501 RVLLMELEEARGNHVIRDEEVSSADISSSSEVISQH---LVSYRNIEELQQQNQRLLVAL 557
Query: 614 RELIE--KERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPD----V 667
REL E + + E + + I + Q KL+ + E +QL + + +Q + + + D +
Sbjct: 558 RELGETREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRIL 617
Query: 668 KGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAI 727
T + IP +A + D SL T + Q + +
Sbjct: 618 LSQTTGVAIP-----------LHASSLDDVSL-------ASTPKRPSTSQTVSTPAPVPV 659
Query: 728 NYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHL 787
S + +A + L++ ++ + N + L + + SQN +
Sbjct: 660 IESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEK--LQEQVTDLRSQN---TKI 714
Query: 788 LQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKL 847
+L+ K+ + L+D++E Y R+ + + L +++ T ++ ++ KL
Sbjct: 715 STQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKL 774
Query: 848 E-DQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRK---ITVLQVNEKSLIRQYTTL 903
+V+ + +K ++ L+ +++ S + + +LAE + +T LQ + L R T
Sbjct: 775 AVAEVRAENLKKEKEMLKLSEVRL-SQQRESLLAEQRGQNLLLTNLQTIQGILERSET-- 831
Query: 904 VELERQLRKENEKQKNELLSMEAEV---CEKIGCLQRFKEMAIFKIAALQKVVDNSVSLS 960
E +++L + EK ++E+ ++ ++ E+ L R ++ + Q + ++ L+
Sbjct: 832 -ETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLD-TKRQLDTETNLHLN 889
Query: 961 ELELANKQYNELTAKYRDILQKDNMLVQRTS-NLEHLECENISLKEQVESINKELEITKE 1019
EL E+ + + NM VQ S + + S KE V+ + +L T+E
Sbjct: 890 TKELLKNAQKEIATLKQHL---SNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEE 946
Query: 1020 KLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKM 1079
+++ +++ + T S++ +T LE E+Q E +K
Sbjct: 947 QVNDLKERLKTST-----------------SNVEQYQAMVTSLEESLNKEKQVTEEVRK- 988
Query: 1080 YEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRIL 1139
++ LK+ E +LE K E+ K + EL D +A+ + Q++
Sbjct: 989 --NIEVRLKESAEFQTQLEKKLMEVEK-----------EKQELQDDKRRAIESME-QQLS 1034
Query: 1140 ELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSL 1199
EL+K ++ EV + + R + N QQ RD Q K
Sbjct: 1035 ELKKTLSSVQNEVQEA-----LQRASTALSNEQQARRD--------------CQEQAKIA 1075
Query: 1200 IAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNR 1259
+ +++ L L A + L++ ++ KM + LE+ + E L + R
Sbjct: 1076 VEAQNKYERELML-HAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEER 1134
Query: 1260 AKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKL------KIMQEMKNSQQEHRN 1313
+ L+ + + L +Q + I+ +DK+ + + S E
Sbjct: 1135 ERMLKDEVS---KCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGK 1191
Query: 1314 MENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIK 1373
+ + LE+ ++ +E+ T + + + + ++E L + +L L ++E+++
Sbjct: 1192 SQEQILEILRFIRREKEIAETRFEVAQVES-LRYRQRVELLERELQELQDSLNAEREKVQ 1250
Query: 1374 YLNNIISEYERTISSLE--EEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNA 1431
++++E + E +++ NK E + ++ E DL++ + + +IL
Sbjct: 1251 VTAKTMAQHEELMKKTETMNVVMETNKMLREEK---ERLEQDLQQMQAKVRKLELDIL-- 1305
Query: 1432 AQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLA 1491
+EA + + S L+ + ++E+++ K+ + L ++
Sbjct: 1306 --PLQEANAELSEKS----GMLQAEKKLLEEDVK-------RWKARNQHLVSQQKDPDTE 1352
Query: 1492 EQNILSRDKVINELRLRLPATAEREKLIAELGRKEME-PKSHHTLKIAHQTIANMQARLN 1550
E L +K ++ R+ ++L E+GR + E +S+ +L I +++ LN
Sbjct: 1353 EYRKLLSEKEVHTKRI--------QQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLN 1404
Query: 1551 ----QKEEVLKKYQRLLEKAREEQREI--VKKHEEDLHILHHRLELQADSSLNKFKQTAW 1604
+KE + K + +E+ + I VKK + L+ Q D + Q++
Sbjct: 1405 KVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSG 1464
Query: 1605 DLMKQ--SPTPVPTNKHFIRLAE------------MEQTVAEQDDSLSSLLVKLKKVSQD 1650
D +Q S + K + AE +++T++E++ +L + ++ +
Sbjct: 1465 DHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSE 1524
Query: 1651 LERQREITELKVKEFENIKLQLQENHEDEVKKV---KAEVEDLKYLLDQSQKESQCLKSE 1707
L R R+ + + + E ++ Q+ E E K + K+++ L + DQ KE++ LK
Sbjct: 1525 LSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQR 1584
Query: 1708 LQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEER 1762
A + ALK + + +SR ELR E+R
Sbjct: 1585 NGALDQQKDELDVRI-----------TALKSQYEGRISRLERELREHQERHLEQR 1628
Score = 172 bits (435), Expect = 5e-42
Identities = 337/1658 (20%), Positives = 689/1658 (41%), Gaps = 184/1658 (11%)
Query: 769 IAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLS 828
++ S ++N E Q L + +KL N +L + N++ + + + + ++
Sbjct: 61 LSHSQERLVNETRE-----CQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTR 115
Query: 829 EKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITV 888
KE + E + + +L +++ VK N L E++ L E
Sbjct: 116 TKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVS 175
Query: 889 LQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAA 948
++ EK L ++ L L E + + +ELL++ E +I L+ E +++
Sbjct: 176 VKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSR 235
Query: 949 LQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNL--EHLECENI--SLK 1004
L++ + N + S L K +L K ++ ++ + ++ N H++ N+ S
Sbjct: 236 LEEQM-NGLKTSNEHL-QKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAA 293
Query: 1005 EQVESINKELEITKEKLHTI-EQAWE-----QETKLGNESSMDKAKKSITN--------- 1049
+ E+ + EL E+LH + ++A E Q+ L E S D+ +K +
Sbjct: 294 DDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKEL 353
Query: 1050 ---SDIVSISK-KITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELT 1105
+D++S +K K +L +EL + + + ++ +K E N +ET+ +L
Sbjct: 354 ENANDLLSATKRKGAILSEEEL--AAMSPTAAAVAKIVKPGMKLTELYNAYVETQ-DQLL 410
Query: 1106 KINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQ 1165
L+ +++ + L DE+ V RQR + + V + + +I R Q
Sbjct: 411 LEKLENKRINKYL-DEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQ 469
Query: 1166 VEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESIT 1225
+ A +QS E ++ RM++ + L+ +L + + + + S +
Sbjct: 470 EDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSS 529
Query: 1226 SKLQKMEAYNLRLEQKLDEKEQALYYARLE-GRNRAKHLRQTIQS----LRRQFSGALPL 1280
S++ + R ++L ++ Q L A E G R + ++T S L+ + AL
Sbjct: 530 SEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTE 589
Query: 1281 AQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLE----ELISTLK 1336
+Q + S+ +++++ + + +R + ++T + + L L ST K
Sbjct: 590 LEQLRKSR------QHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK 643
Query: 1337 DTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQ 1396
+Q V + + + + E ++ K +K L I Y++ E E +Q
Sbjct: 644 RPSTSQTV-STPAPVPVIE------STEAIEAKAALKQLQEIFENYKK--EKAENEKIQN 694
Query: 1397 NKFHEERQMAWDQREVD--LERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLP---N 1451
+ + ++ D R + + QLD ++ + + + + S+ + + L
Sbjct: 695 EQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
Query: 1452 QLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILS-RDKVINELRLRLP 1510
+ E + + +++R E A + E LK+++ L+L+E + R+ ++ E R +
Sbjct: 755 KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
Query: 1511 ATAEREKLIAELGRKEMEPK---SHHTLKIAHQTIANMQARLNQKEEVLKKYQR-----L 1562
+ + L R E E K S K+ H+ I++++ +L + E R L
Sbjct: 815 LLTNLQTIQGILERSETETKQRLSSQIEKLEHE-ISHLKKKLENEVEQRHTLTRNLDVQL 873
Query: 1563 LEKARE---------EQREIVKKHEEDLHILHHRL---ELQADSSLNKF--------KQT 1602
L+ R+ +E++K ++++ L L E+Q S ++ K+
Sbjct: 874 LDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKED 933
Query: 1603 AWDLMKQ-SPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELK 1661
DL+ Q T N RL V + ++SL L K Q E R+ E++
Sbjct: 934 VDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVR 993
Query: 1662 VKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKE-----SQCLKSELQAQKEANS 1716
+KE + QL E EV+K K E++D K +S ++ + L S +EA
Sbjct: 994 LKESAEFQTQL-EKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQ 1052
Query: 1717 RAPTTTMRNLVER--LKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHL 1774
RA T R + Q + + Q R L+ + AA E + +A Q
Sbjct: 1053 RASTALSNEQQARRDCQEQAKIAVEAQNKYERELM-----LHAADVEALQAAKEQVSKMA 1107
Query: 1775 NVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYN 1834
+V+Q ++ T++ ++Q L E + + RE L D ++ + +K N
Sbjct: 1108 SVRQHLEETTQKAESQ----------LLECKASWEERERMLKDEVSKCVCRCEDLEK-QN 1156
Query: 1835 KILREKEEIDQENDELKRQIKRLTSGLQGKPLTD--NKQSLIEELQRKVKKLENQLEGKV 1892
++L ++I++ +D++ +K G L++ Q I E+ R +++ + E +
Sbjct: 1157 RLLH--DQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRF 1214
Query: 1893 EEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLK------EKEGEVFTLTKQLNTL 1946
E ++ ++ + E L R E ++ Q + R K++ + E+ T+ +N +
Sbjct: 1215 EVAQVESLRYRQRVELLER--ELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVV 1272
Query: 1947 KDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAH 2006
+ +EK L++ L Q + + + E ++ L++ N +L ++A
Sbjct: 1273 METNKMLREEKERLEQDL--------QQMQAKVRKLELDILPLQEANAELSEKSGMLQAE 1324
Query: 2007 QALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENL 2066
+ L + V R+ H + +Q DT + E + H +R Q+L +E
Sbjct: 1325 KKLLEEDV-------KRWKARNQHLVSQQKDPDTEEYRKLLS-EKEVHTKRIQQLTEEIG 1376
Query: 2067 KLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKT 2126
+L +E + ++N L +N ++ LKE ++ EK +Q+ L
Sbjct: 1377 RLKAE-------IARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDL------DAKIID 1423
Query: 2127 IPELEKTIGLMKKVVEKVQRENEQLKKASG--ILTSEKMANIEQENEKLKAELEKLKAHL 2184
I E KTI +KK+ + + + E+LK + TS + + QE E+++LK L
Sbjct: 1424 IQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETL 1483
Query: 2185 GHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEET 2244
E+K+K E ++ E L+K L ++ A L+ L+ ++ L++
Sbjct: 1484 NQA-----ETKSKSLE---SQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQD- 1534
Query: 2245 GKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEAT 2304
R E Q+ + K+ K+IV + L ++ + K+N+ E
Sbjct: 1535 --RTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENE----------ELK 1582
Query: 2305 EREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQ 2342
+R +++ ++L+ +I LK EG + L+REL+
Sbjct: 1583 QRNGALDQQKDELDVRITALKSQYEGRISR--LERELR 1618
Score = 171 bits (432), Expect = 1e-41
Identities = 327/1604 (20%), Positives = 662/1604 (41%), Gaps = 223/1604 (13%)
Query: 971 ELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQ 1030
E +Y +I ++ + +R N E EC+ SL+ ++E +N +L+ EK +E A ++
Sbjct: 49 ESEQQYFEIEKRLSHSQERLVN-ETRECQ--SLRLELEKLNNQLKALTEKNKELEIAQDR 105
Query: 1031 ETKLGNESSMDKAKKSITNSDIVSISKKITML------EMKELNERQRAEHCQKMYEHLR 1084
+ ++ + K + D++ +++++ ++K LNE+ + + K L+
Sbjct: 106 NIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLK 165
Query: 1085 TSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSK--AVSDADRQRILELE 1142
Q + + + K E K L +Q L EL + A+ ILEL+
Sbjct: 166 LDELQASDVSVKYREKRLEQEKELLHSQNT--WLNTELKTKTDELLALGREKGNEILELK 223
Query: 1143 KNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAK 1202
N K EVS+L E Q+ L + K VE L +L + A+ + S+ K
Sbjct: 224 CNLENKKEEVSRLEE-------QMNGLKTSNEHLQKHVEDLLTKLKE--AKEQQASMEEK 274
Query: 1203 LHQH-NVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAK 1261
H N ++LS S EA + L + ++E + L A +
Sbjct: 275 FHNELNAHIKLSNL--------YKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQD 326
Query: 1262 HLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEM 1321
HL + QS +++ K M++ ++ +E++N+ L
Sbjct: 327 HLLEVEQS-------------KDQMEKEMLEKIG---RLEKELENAND---------LLS 361
Query: 1322 ELKLKGL----EELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNN 1377
K KG EEL + K++ MK+ EL ++ +L+ +K E K +N
Sbjct: 362 ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINK 421
Query: 1378 IISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEE 1437
+ E + + + + +Q + +E Q A V LE+ + R Q + A ++
Sbjct: 422 YLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQ--- 478
Query: 1438 ATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILS 1497
S+ + ++EI ++ + + IR++L + E+ S+ ++ + +
Sbjct: 479 --SSVLERD---NRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVI 533
Query: 1498 RDKVINELRLRLPATAEREKLIA--ELGR-KEMEPKSHHTLKIAHQTIANMQARLNQKEE 1554
+++ + + L+A ELG +E E + + KI + +++ L + E+
Sbjct: 534 SQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQL-KLESALTELEQ 592
Query: 1555 VLKKYQRLLEKA-----REEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQ 1609
+ K Q ++ + + I+ + I H L S + K+ +
Sbjct: 593 LRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVS 652
Query: 1610 SPTPVPTNKH---------FIRLAEM----EQTVAEQDDSLSSLLVKLKKVSQDLERQRE 1656
+P PVP + +L E+ ++ AE + + L KL++ DL Q
Sbjct: 653 TPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNT 712
Query: 1657 ITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANS 1716
++ LQ+N E +++ + E + L +QK+ Q + + Q + AN
Sbjct: 713 KISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANE 772
Query: 1717 RAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAE--ERIISATSQKEAHL 1774
+ +R E LK KEK+ LS L + E A + + ++ Q
Sbjct: 773 KLAVAEVR--AENLK-----KEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQ----- 820
Query: 1775 NVQQIVDRHTRELK----TQVEDLNENLLKLKEALKTSKNRENSLTDNLN---------- 1820
+Q I++R E K +Q+E L + LK+ L+ + ++LT NL+
Sbjct: 821 TIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQL 880
Query: 1821 --DLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQ 1878
+ N L K+ N +E + Q ++ Q+ +S GK NK+ +++L
Sbjct: 881 DTETNLHLNTKELLKNA-QKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKED-VDDLV 938
Query: 1879 RKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKI-EGIRNKLKEKEGEVF 1937
++++ E Q+ E + + + + EE + ++ E +R ++ + E
Sbjct: 939 SQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESA 998
Query: 1938 TLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALES-EKELEELKKRNLDL 1996
QL K L + +KEK LQ + RA+ES E++L ELKK +
Sbjct: 999 EFQTQLE--KKLM-EVEKEKQELQDDKR------------RAIESMEQQLSELKKTLSSV 1043
Query: 1997 ENDI--LYMRAHQALPRDSVVED---------LHLQNRYLQE-KLHALEKQFSKDTYSKP 2044
+N++ RA AL + + QN+Y +E LHA + + + +K
Sbjct: 1044 QNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQA--AKE 1101
Query: 2045 SISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLK 2104
+S + S Q L++ K S+ +E K E+ + LK++V CE L+
Sbjct: 1102 QVSKMASV-----RQHLEETTQKAESQLLECKASWEERER---MLKDEVSKCVCRCEDLE 1153
Query: 2105 KEKA----EVQRKLGHVRGSGRSGKTIP------ELEKTIGLMKKVVEKVQRENE----- 2149
K+ ++++ V S + G P E K+ + +++ ++RE E
Sbjct: 1154 KQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETR 1213
Query: 2150 -QLKKASGILTSEKMANIEQE----NEKLKAELEKLKAHLGHQLSMHYE--SKTKGTEKI 2202
++ + + +++ +E+E + L AE EK++ ++ H E KT+ +
Sbjct: 1214 FEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQV-TAKTMAQHEELMKKTETMNVV 1272
Query: 2203 IAENERLRKELKKETDAAEKLRIAKNNLEI-----------LNEKMTVQ------LEETG 2245
+ N+ LR+E ++ ++++ LE+ L+EK + LEE
Sbjct: 1273 METNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDV 1332
Query: 2246 KRLQFAESR-GPQLEGADSKSWKSIVVTRMYETK--------LKELETDIAKKNQSITDL 2296
KR + Q + D++ ++ ++ + TK + L+ +IA+ N S+T+
Sbjct: 1333 KRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNN 1392
Query: 2297 KQLVKEATEREQKVNKYNEDLEQQI--KILKHVPEGAETEQGLKRELQVLRLANHQLDKE 2354
+ L++ E KV E +++ + KI+ + E +T +K+ + R Q ++
Sbjct: 1393 QNLIQSLKEDLNKVRTEKETIQKDLDAKIID-IQEKVKTITQVKK---IGRRYKTQYEEL 1448
Query: 2355 KAELIHQIEANKDQSGAES----TIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLK 2410
KA+ +E + SG ++ + +LKE + ET+ K + + ++L++ + + +
Sbjct: 1449 KAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKE 1508
Query: 2411 KELENFDPSFFE---EIEDLKYNYKEEVKKNILLEEKVKKLSEQ 2451
E N + E+ L+ + ++ + L +++ + E+
Sbjct: 1509 TEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEK 1552
Score = 121 bits (304), Expect = 7e-27
Identities = 259/1299 (19%), Positives = 530/1299 (40%), Gaps = 205/1299 (15%)
Query: 1268 QSLRRQFSGALPLAQQEKFSKTMIQLQND---------KLKIMQEMKNSQQEHR------ 1312
Q L R LP + Q K K + Q++ K K+ E + + E R
Sbjct: 7 QVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQE 66
Query: 1313 NMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEI 1372
+ N+T E + LE+L + LK K ++E + + + + + + KEE+
Sbjct: 67 RLVNETRECQSLRLELEKLNNQLKALTEKNK------ELEIAQDRNIAIQSQFTRTKEEL 120
Query: 1373 KYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAA 1432
+ + +S E + + K E+ + + +L+ +LD +
Sbjct: 121 EAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYRE 180
Query: 1433 QKFEEATGSIPDPSLPLPNQLEIALRKI----KENIRIILETRATCKSLEE---KLKEKE 1485
++ E+ + + L +L+ ++ +E ILE + ++ +E +L+E+
Sbjct: 181 KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQM 240
Query: 1486 SALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANM 1545
+ L+ + +++ K + +L +L E++ ME K H+ L AH ++N+
Sbjct: 241 NGLKTSNEHL---QKHVEDLLTKLKEAKEQQA--------SMEEKFHNELN-AHIKLSNL 288
Query: 1546 --------QARLNQKEEVLKKYQRLLEKAREEQREIV--------KKHEEDLHILHH--R 1587
+A+ N+ +++ +LL++A E + I K + + +L R
Sbjct: 289 YKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGR 348
Query: 1588 LELQADSSLNKFKQTAW--------DLMKQSPTPVPTNKHF---IRLAEMEQTVAEQDDS 1636
LE + +++ + T +L SPT K ++L E+ E D
Sbjct: 349 LEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQ 408
Query: 1637 LSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQ 1696
L ++ K++++ L+ EI VKE E K + + +E ++ + V L L+Q
Sbjct: 409 LLLEKLENKRINKYLD---EI----VKEVE-AKAPILKRQREEYERAQKAVASLSVKLEQ 460
Query: 1697 SQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMT 1756
+ KE Q L+ + +AN ++ N R++ Q+ +Q + L L E R
Sbjct: 461 AMKEIQRLQEDTD---KANKQSSVLERDN--RRMEIQVKDLSQQIRVLLMELEEARGNHV 515
Query: 1757 AAAEERIISATSQKEAHLNVQQIVD-RHTRELKTQVEDLNENLLKL-----KEALKTSKN 1810
EE + SA + + Q +V R+ EL+ Q + L L +L +E +T+ +
Sbjct: 516 IRDEE-VSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSS 574
Query: 1811 RENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTS---GLQGKPLT 1867
+ L L EL++ +K+ ++ + I ++ D + + + T L L
Sbjct: 575 KITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLD 634
Query: 1868 D-----------NKQSLIEELQRKVKKLENQLEGKVEEVDLKPM----KEKNAKEELIRW 1912
D Q++ V + +E K L+ + K++ A+ E I+
Sbjct: 635 DVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQN 694
Query: 1913 EEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQ---RKLKTTGM 1969
E+ +K Q ++ +R++ + ++ +K+ L+D +E +L +KL T
Sbjct: 695 EQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQ 754
Query: 1970 TVDQVLG-----IRALESEKELEELKKRNLDLENDILYM-RAHQALPRDSVVEDLHLQNR 2023
+Q++ +R + + E++ NL E ++L + + R+S++ + QN
Sbjct: 755 KQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
Query: 2024 YLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQAN 2083
L + +I GI + +Q L + KL E LK +LE
Sbjct: 815 LLT---------------NLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLE--- 856
Query: 2084 KDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTI-PELEKTIGLMKKVVE 2142
N+V + L + + +R+L + K + +K I +K+ +
Sbjct: 857 -------NEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLS 909
Query: 2143 KVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKI 2202
++ Q+ S T + + +++ + L ++L + + + + L ++ T E+
Sbjct: 910 NME---VQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQV-NDLKERLKTSTSNVEQY 965
Query: 2203 IAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGAD 2262
A L + L KE E++R N+E+ ++ + K+L E +L+
Sbjct: 966 QAMVTSLEESLNKEKQVTEEVR---KNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDK 1022
Query: 2263 SKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIK 2322
++ +S+ E +L EL+ ++ + + Q A EQ+ + D ++Q K
Sbjct: 1023 RRAIESM------EQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARR---DCQEQAK 1073
Query: 2323 ILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLK 2382
I E + +REL + H D E ++A K+Q +++ L+
Sbjct: 1074 I------AVEAQNKYERELML-----HAADVEA------LQAAKEQVSKMASV--RQHLE 1114
Query: 2383 EKIKDLETQL---KMSDLEKQH-LKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKN 2438
E + E+QL K S E++ LK+E+ K E+ + K+N
Sbjct: 1115 ETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLE------------------KQN 1156
Query: 2439 ILLEEKVKKLSEQL------GVELTSPVAASEEFEDEEE 2471
LL ++++KLS+++ GV+ V+ SEE + +E+
Sbjct: 1157 RLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQ 1195
Score = 115 bits (289), Expect = 4e-25
Identities = 231/1062 (21%), Positives = 445/1062 (41%), Gaps = 149/1062 (14%)
Query: 1480 KLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAH 1539
K++ ++ + ++ S+++++NE R E EKL +L K + K+ L+IA
Sbjct: 47 KVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQL--KALTEKNKE-LEIAQ 103
Query: 1540 QTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKF 1599
+Q++ + +E L+ +R L + E + ++ ED+ L+ +L+ +S+ K
Sbjct: 104 DRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLK---ESNTTKG 160
Query: 1600 K-QTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDL-----ER 1653
+ Q D ++ S V + RL + ++ + Q+ L++ +LK + +L E+
Sbjct: 161 ELQLKLDELQASDVSVKYREK--RLEQEKELLHSQNTWLNT---ELKTKTDELLALGREK 215
Query: 1654 QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKE 1713
EI ELK EN ++EV +++ ++ LK + QK + L ++L+ KE
Sbjct: 216 GNEILELKCN---------LENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKE 266
Query: 1714 ANSRAPTTTMRNLVERLKSQLALK------EKQQKALSRALLELRAEMTAAAEERIISAT 1767
+ L +K K E + L+RA+ EL + A E A
Sbjct: 267 QQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGE-----AN 321
Query: 1768 SQKEAHL-NVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNEL 1826
+ HL V+Q D+ +E+ ++ L + L +N NDL +
Sbjct: 322 KAIQDHLLEVEQSKDQMEKEMLEKIGRLEKEL------------------ENANDLLSAT 363
Query: 1827 QKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTD-----NKQSLIEELQRKV 1881
++K IL E EE+ + K + G++ L + Q L+E+L+ K
Sbjct: 364 KRK----GAILSE-EELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK- 417
Query: 1882 KKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEG-KKWQAKIEGIRNKLKEKEGEVFTLT 1940
++ L+ V+EV+ K K +EE R ++ K+E +++ + +
Sbjct: 418 -RINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKAN 476
Query: 1941 KQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDI 2000
KQ + L+ + + + L ++++ M +++ G + E E+ ++ +++
Sbjct: 477 KQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDE----EVSSADISSSSEV 532
Query: 2001 LYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQE 2060
+ Q L +E+L QN+ L L L + ++ E + + E
Sbjct: 533 I----SQHLVSYRNIEELQQQNQRLLVALRELGETRERE----------EQETTSSKITE 578
Query: 2061 LQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLG----- 2115
LQ LKL S EL+ QL ++ + +L + + ++M L + V L
Sbjct: 579 LQ---LKLESALTELE-QLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLD 634
Query: 2116 --HVRGSGRSGKT---------IPELEKTIGL-MKKVVEKVQRENEQLKKASGILTSEKM 2163
+ + + T +P +E T + K ++++Q E KK +EK+
Sbjct: 635 DVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKA--ENEKI 692
Query: 2164 ANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKL 2223
N ++ EKL+ ++ L++ ++S + +K E + E R+E+ + +KL
Sbjct: 693 QN--EQLEKLQEQVTDLRSQ-NTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKL 749
Query: 2224 RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELE 2283
E + MT L ++L AE R L+ K + R+ + + + L
Sbjct: 750 TATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLK--KEKEMLKLSEVRLSQQR-ESLL 806
Query: 2284 TDIAKKNQSITDLKQ----LVKEATEREQKVNKYNEDLEQQIKILKHVPEG-AETEQGLK 2338
+ +N +T+L+ L + TE +Q+++ E LE +I LK E E L
Sbjct: 807 AEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLT 866
Query: 2339 RELQVLRL-ANHQLD-----------------KEKAEL---IHQIEANKDQSGAESTIPD 2377
R L V L QLD KE A L + +E ++ T
Sbjct: 867 RNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKG 926
Query: 2378 ADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDP--SFFEEIEDLKYNYKEEV 2435
KE + DL +QL+ ++ + LKE +K +E + + EE + + EEV
Sbjct: 927 QPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEV 986
Query: 2436 KKNILLEEKVKKLSE---QLGVELTSPVAASEEFEDEEESPV 2474
+KNI E ++K+ +E QL +L +E +D++ +
Sbjct: 987 RKNI--EVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAI 1026
Score = 60.8 bits (146), Expect = 2e-08
Identities = 104/493 (21%), Positives = 211/493 (42%), Gaps = 56/493 (11%)
Query: 1980 LESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKD 2039
L+ E EL K ++N + A Q D L+ R+ + K+ + ++ F +
Sbjct: 5 LQQVLERTELNKLPKSVQNKLEKFLADQQSEIDG------LKGRHEKFKVESEQQYFEIE 58
Query: 2040 TYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEM 2099
S + ++ +E Q L+L N +LK L + NK+L ++ R++
Sbjct: 59 KRLSHSQERLVNET-----RECQSLRLELEKLNNQLK-ALTEKNKELEIAQD--RNIAIQ 110
Query: 2100 CEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENE-----QLK-- 2152
+F + ++ K +R + R + ELE +K++ EK++ N QLK
Sbjct: 111 SQFTRTKEELEAEKRDLIRTNERLSQ---ELEYLTEDVKRLNEKLKESNTTKGELQLKLD 167
Query: 2153 --KASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENER-- 2208
+AS + + +EQE E L ++ L L KTK E + E+
Sbjct: 168 ELQASDVSVKYREKRLEQEKELLHSQNTWLNTEL----------KTKTDELLALGREKGN 217
Query: 2209 ----LRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSK 2264
L+ L+ + + +L N L+ NE + +E+ +L+ A+ + +E
Sbjct: 218 EILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHN 277
Query: 2265 SWKS-IVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKI 2323
+ I ++ +Y++ + E + +++ +L +L+KEA E + + + ++EQ
Sbjct: 278 ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ 337
Query: 2324 LKHVPEGAETEQGLKRELQVLRLANHQLD--KEKAELIHQIE--ANKDQSGAESTIPDAD 2379
++ E E L++EL+ AN L K K ++ + E A + A + I
Sbjct: 338 MEK--EMLEKIGRLEKELEN---ANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPG 392
Query: 2380 ----QLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEV 2435
+L + + QL + LE + + + + ++ KE+E P + E+ + K
Sbjct: 393 MKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA 452
Query: 2436 KKNILLEEKVKKL 2448
++ LE+ +K++
Sbjct: 453 SLSVKLEQAMKEI 465
Score = 50.8 bits (120), Expect = 2e-05
Identities = 50/239 (20%), Positives = 114/239 (47%), Gaps = 20/239 (8%)
Query: 27 NLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQ 86
NL+ SL K ++N++++EK+ L + QE + +V+K G +
Sbjct: 1394 NLIQSL-KEDLNKVRTEKETIQKDL-----DAKIIDIQEKVKTITQVKKIGRRYKTQYEE 1447
Query: 87 LKTKVMKLENELEMAQQSAGG--------RDTRFLRNEICQLEKQLEQKDRELEDMEKEL 138
LK + K+ +E + QS+G ++ + L+ + Q E + + + ++E+++K L
Sbjct: 1448 LKAQQDKV---METSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTL 1504
Query: 139 EKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRR 198
+++ L + + ++E S+LR++ + + EQL Q I + +++ S+
Sbjct: 1505 SEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKI 1564
Query: 199 GEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEY 257
+ + QL+K+N EL Q L + ++++V+ ++ E + +E+ E+
Sbjct: 1565 AHLAGVKDQLTKENEELKQ---RNGALDQQKDELDVRITALKSQYEGRISRLERELREH 1620
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 191 bits (484), Expect = 1e-47
Identities = 293/1366 (21%), Positives = 604/1366 (44%), Gaps = 199/1366 (14%)
Query: 109 DTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQ-----------------LALR 151
D LR E+ L+ L+++ E+++KELEK + + +Q L +
Sbjct: 84 DVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQ 143
Query: 152 NEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKK 211
EEA+ EN +++ ++K QL +I D + + D ++ + + + +L+K+
Sbjct: 144 LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKE 203
Query: 212 -------NYELIQY--LDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKA 262
EL+Q ++++ L + E ++VQ LE +E EK+ DE ++++
Sbjct: 204 ATVIQDLKTELLQRPGIEDVAVLKK--ELVQVQTLMDNMTLERE-RESEKLKDECKKLQS 260
Query: 263 IVHQTDNVIDQLKKE----NDHYQLQVQELTDLLKSKNE---EDDPIMVAVNAKVEEWKL 315
++ I QL+ E + VQEL L S NE ++ + + K +++
Sbjct: 261 QYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTK 320
Query: 316 ILSSKDDEIIEYQQMLHNLREKLKNAQLDAD--KSNVMALQQGIQERDSQIKMLTEQVEQ 373
+ ++E + + N++ L LD +S + A + + ++ E ++
Sbjct: 321 LEEKHNEESVSKK----NIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376
Query: 374 YTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEAD 433
+E+ + + LK E ++ + +Q +++QS ++ L K E ER +L EA
Sbjct: 377 LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER--QLGEAH 434
Query: 434 AREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKI 493
R K++ + + ++L D E V L Q+K+ E ++ K N EL+
Sbjct: 435 GRLKEQRQLSS-EKLMDKEQQVADL------------QLKLSRLEEQLKEKVTNSTELQH 481
Query: 494 SDFLDE-NEALRERVGLEPKTMIDLTEFRN----------SKHLKQQQYRAENQILLKEI 542
LD+ + +E+ L+ T L E +N K K Q A Q + I
Sbjct: 482 Q--LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI 539
Query: 543 ESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNM 602
LE+ER DL KI+ G+ + + L ++ L E ++Q ++E+ LKN
Sbjct: 540 SLLEKEREDLYAKIQ---AGEGETAVLNQLQEKNHTLQEQVTQ---LTEK------LKNQ 587
Query: 603 SEAQSK-NEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEM 661
SE+ + E L ++ E++ L ++ + + + EL N QL E +++ Q ++
Sbjct: 588 SESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL---NSQLNESKEKVSQLDIQI 644
Query: 662 QKDPDV-------KGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNE- 713
+ ++ K + + + L+ NA++ K E + Q+DQ+T + +
Sbjct: 645 KAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQE-----LNKITTQLDQVTAKLQD 699
Query: 714 ------ELRQELRESRKEAINYSQQLAKANLKIDHLE---------KETSL--LRQSEGS 756
+L L+E +++ ++ Q+ + +I LE KE +L L+Q
Sbjct: 700 KQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQL 759
Query: 757 NV--------VFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDY 808
N + K +++ I S+ + ++E L + Q+L +E++ + L+ E
Sbjct: 760 NTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETL 819
Query: 809 NRKFAVIRHQQ--------SLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKE 860
+++ I+H++ ++ EKE TE T+K++ K+ D ++ + ++
Sbjct: 820 SQE-TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
Query: 861 YNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENE---KQ 917
N A +D ++ K L LQV ++ +++ EL++ L KE E +
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQ------LQVQMENTLKEQK---ELKKSLEKEKEASHQL 929
Query: 918 KNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYR 977
K EL SM+ ++ + L++ ++ Q++ N ++EL KQ +E K
Sbjct: 930 KLELNSMQEQLIQAQNTLKQNEKEE-------QQLQGN---INEL----KQSSEQKKKQI 975
Query: 978 DILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNE 1037
+ LQ + + + L+ E EN L++Q+ +EL KEK+ ++ +E+ + +
Sbjct: 976 EALQGE----LKIAVLQKTELEN-KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030
Query: 1038 SSMD----KAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEER 1093
D +++ T D+ S+ +K+++ + ++ R + + K+ + L+T+ +E+
Sbjct: 1031 LQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQD 1090
Query: 1094 NFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVS 1153
+ + E + E K D QK + + EL + SK + E+E+ + + E++
Sbjct: 1091 SAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSK---------LAEIEEIKCRQEKEIT 1141
Query: 1154 KLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLS 1213
KL E ++ ++E + +D + + L Q L+ Q ++D SL A + Q + Q+
Sbjct: 1142 KLNE--ELKSHKLESIKEITNLKDAK-QLLIQQKLELQGKAD--SLKAAVEQEKRNQQIL 1196
Query: 1214 EATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQ 1273
+ + E + + + EA +L ++ EKE + + N AK L I +L
Sbjct: 1197 KDQVKKEEEELKKEFIEKEA---KLHSEIKEKEVGM---KKHEENEAK-LTMQITALNEN 1249
Query: 1274 FSGALPLAQQEKFSKTMIQLQNDKLK-----IMQEMKNSQQEHRNMENKTLEMELKLKGL 1328
Q + + ++ Q D L+ + ++N+Q E R + + L+ E +++ L
Sbjct: 1250 LGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKL 1309
Query: 1329 E----ELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKE 1370
+ EL L +T A + + + +++ + LNR+ +D E
Sbjct: 1310 QTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQ-ALNRKWAEDNE 1354
Score = 184 bits (467), Expect = 9e-46
Identities = 285/1348 (21%), Positives = 581/1348 (43%), Gaps = 171/1348 (12%)
Query: 322 DEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKN 381
DE+ ++ + +H DA + + + + + +L ++V+ +++
Sbjct: 54 DELFKHYEAVH-----------DAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEE 102
Query: 382 TCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKEL 441
E+LK EL++ +G QQ K + + + E+ E A+ +
Sbjct: 103 KWYSEELKKELEKYQGL----QQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFN----- 153
Query: 442 VEALKRLKD-YESGVYGLEDAVVEIKNCKNQIK----IRDREIEILTKEINKLELKISDF 496
+K++KD +E L + +IK+ ++ + ++++ LT+E+NK I D
Sbjct: 154 ---IKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDL 210
Query: 497 LDENEALRERVGLEP-----------KTMID---LTEFRNSKHLKQQQYRAENQILLKE- 541
E L +R G+E +T++D L R S+ LK + + ++Q E
Sbjct: 211 KTE---LLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEA 267
Query: 542 -IESLEEERLDLKKKIRQMAQERGK-RSATSGLTTEDLNLTENISQGDRISERKLDLLSL 599
I L E +++ QE K +S+ + LT ++ LTEN+ + E+ L
Sbjct: 268 TISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLK----KEQDYTKLEE 323
Query: 600 KNMSEAQSKNEFLSRELIEKERD-------LERSRTVIAKFQNKLKELVEENKQLEEGMK 652
K+ E+ SK + L +K+ D L S T + + +L E E ++L+E +
Sbjct: 324 KHNEESVSKKN-IQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS 382
Query: 653 EI---LQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLT 709
E+ Q +K K + E L+ +N + SK L + Q+ +
Sbjct: 383 EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK--------LLETERQLGEAH 434
Query: 710 GRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKE--------TSLLRQSEGSNVVFK 761
GR +E RQ S ++ ++ QQ+A LK+ LE++ T L Q + + +
Sbjct: 435 GRLKEQRQ---LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQ 491
Query: 762 GIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSL 821
+ S+ + + L +L+++ +K++K++NLE L+ +++ ++
Sbjct: 492 E---QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKERED 548
Query: 822 LYKE------------YLSEK------------ETWKTESKTIKEEKRKLEDQVQQDAIK 857
LY + L EK E K +S++ K+ + L DQVQ+
Sbjct: 549 LYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH 608
Query: 858 VKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQ 917
++ + + +L+ +E+ L E+ K++ L + K+ + L+ E +
Sbjct: 609 LRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA---KTELLLSAEAAKTAQRADL 665
Query: 918 KNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYR 977
+N L + + + +K Q ++ K+ D S+LE K+Y E KY
Sbjct: 666 QNHLDTAQNALQDK---QQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKE---KYL 719
Query: 978 DILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNE 1037
+ QK L ++ LE +++ +K E ++L+ ++ +E + T+L +
Sbjct: 720 SLEQKTEEL---EGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL---RATELSKQ 773
Query: 1038 SSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLK-QMEERNFE 1096
M+K S T D+ S+ + ++ K + + + ++ +E L K Q EE N
Sbjct: 774 LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
Query: 1097 LETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLR 1156
++T EL K+ ++ + + L + D +SK VSD+ + E EK + K + L
Sbjct: 834 IQTTVTELQKVKMEKEALMTEL-STVKDKLSK-VSDSLKNSKSEFEKENQKGKAAILDLE 891
Query: 1157 EISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEAT 1216
+ + Q+++ Q ++ KE + L+ L + E S KL +++ QL +A
Sbjct: 892 KTCKELKHQLQV---QMENTLKEQKELKKSL----EKEKEASHQLKLELNSMQEQLIQAQ 944
Query: 1217 ALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQT--IQSLRRQF 1274
L+ + Q+++ L+Q ++K++ + L+G + L++T L++Q
Sbjct: 945 --NTLKQNEKEEQQLQGNINELKQSSEQKKKQI--EALQGELKIAVLQKTELENKLQQQL 1000
Query: 1275 SGALP--LAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELI 1332
+ A A++EK S LQN+ K + K Q + E++ L LK +EE +
Sbjct: 1001 TQAAQELAAEKEKIS----VLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKL 1056
Query: 1333 STLKD--TKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLE 1390
S ++ ++ N + I+EL+ + L ++ K +++++ + + ++ S E
Sbjct: 1057 SLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKE 1116
Query: 1391 EEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPL- 1449
+E+V + E + ++E ++ + + + E + ++A + L L
Sbjct: 1117 KELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQ 1176
Query: 1450 --PNQLEIALRKIKENIRIILETRATCKSLEEKLK----EKESAL--RLAEQNILSRDKV 1501
+ L+ A+ + K N +I+ + K EE+LK EKE+ L + E+ + +
Sbjct: 1177 GKADSLKAAVEQEKRNQQIL---KDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHE 1233
Query: 1502 INELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQT------IANMQARLNQKEEV 1555
NE +L + TA E L +KE + ++ QT IA ++A + ++
Sbjct: 1234 ENEAKLTMQITALNENL--GTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQD- 1290
Query: 1556 LKKYQRLLEKAREEQREIVKKHEEDLHI 1583
+ + LLE+ + + EI K + L +
Sbjct: 1291 --ERRALLERCLKGEGEIEKLQTKVLEL 1316
Score = 165 bits (417), Expect = 6e-40
Identities = 228/1070 (21%), Positives = 461/1070 (43%), Gaps = 126/1070 (11%)
Query: 72 EVEKAGEEQAKFENQL---KTKVMKLENELEMAQQSAGGRDTRFLR--NEICQLEKQLEQ 126
E+ + GE K + +L +TK L+ E + QQ ++ L+ +EI QL +L +
Sbjct: 366 ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLE 425
Query: 127 KDRELEDMEKELEKEKKVN-EQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQK 185
+R+L + L+++++++ E+L + ++ + KL R ++LK+K + + Q
Sbjct: 426 TERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK----VTNSTELQH 481
Query: 186 QIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEE 245
Q+D K+ ++ ++L + +L Q L +I + + +E Q+ ++N+
Sbjct: 482 QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL 541
Query: 246 SVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVA 305
+E E D Y +++A +T V++QL+++N Q QV +LT+ LK+++E
Sbjct: 542 LEKERE---DLYAKIQAGEGETA-VLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQEN 597
Query: 306 VNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIK 365
++ +V+E K L + D ++ + ++ L N+QL+ K V L D QIK
Sbjct: 598 LHDQVQEQKAHLRAAQDRVLSLETSVNEL-----NSQLNESKEKVSQL-------DIQIK 645
Query: 366 MLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAER 425
TE + + E K T DL+N L + A QQ KI + LD + K ++ +
Sbjct: 646 AKTELL--LSAEAAK-TAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQE 702
Query: 426 TAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKE 485
E+ +E ++ + ++ ++ E + LE +E+K K Q ++D + + ++
Sbjct: 703 HCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ-ALQDLQQQ---RQ 758
Query: 486 IN-KLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIES 544
+N LEL+ ++ + E +E V + +E S K + E QIL ++ E+
Sbjct: 759 LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818
Query: 545 LEEE----RLDLKKKIRQMAQERGK-RSATSGLTTEDLNLTENISQGDRISERKLDLLSL 599
L +E +L +I+ E K + L TE + + +S ++S+ SL
Sbjct: 819 LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLS---KVSD------SL 869
Query: 600 KNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEE-NKQLEEGMKEILQAI 658
KN SK+EF E++ ++ + I + KEL + Q+E +KE +
Sbjct: 870 KN-----SKSEF--------EKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916
Query: 659 KEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQE 718
K ++K+ + + E+L+ A + + + QL G EL+Q
Sbjct: 917 KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQN---------EKEEQQLQGNINELKQS 967
Query: 719 LRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIIN 778
+ +K+ + + LKI L+K + N
Sbjct: 968 SEQKKKQI-----EALQGELKIAVLQK----------------------------TELEN 994
Query: 779 SQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESK 838
+ L QEL +++K+ L+++ E F ++ E L+ ++ K+ +
Sbjct: 995 KLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEE 1054
Query: 839 TI---KEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQ----V 891
+ +E+ +Q+ ++E L+ DS + ++ L E + + +Q +
Sbjct: 1055 KLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL 1114
Query: 892 NEKSLIRQYTTLVELER---QLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAA 948
EK L+ + + L E+E + KE K EL S + E ++I L+ K++ I +
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE 1174
Query: 949 LQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVE 1008
LQ D+ + E E N+Q + K + K + + ++ + + +K+ E
Sbjct: 1175 LQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEE 1234
Query: 1009 S---INKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMK 1065
+ + ++ E L T+++ W+ + S ++K + I+ ++
Sbjct: 1235 NEAKLTMQITALNENLGTVKKEWQSSQR--RVSELEKQTDDLRG----EIAVLEATVQNN 1288
Query: 1066 ELNERQRAEHCQK---MYEHLRTSLKQMEERNFELETKFAELTKINLDAQ 1112
+ R E C K E L+T + +++ + EL + N Q
Sbjct: 1289 QDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQ 1338
Score = 163 bits (412), Expect = 2e-39
Identities = 282/1355 (20%), Positives = 573/1355 (42%), Gaps = 227/1355 (16%)
Query: 991 SNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNS 1050
SNL + L+++V+ + L+ +EK ++ E E E G + K +T+S
Sbjct: 76 SNLALKRDDVTLLRQEVQDLQASLK--EEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS 133
Query: 1051 DIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLD 1110
S ++ LE Q+ E Q +++ E++ +L T+ A++ K D
Sbjct: 134 -----SAELQSLE-------QQLEEAQTENFNIKQMKDLFEQKAAQLATEIADI-KSKYD 180
Query: 1111 AQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILN 1170
E+ LR+ V++ + +++ + +LK E+ + I D+A + E++
Sbjct: 181 E---ERSLREAAEQKVTRLTEELNKEATVI-----QDLKTELLQRPGIEDVAVLKKELVQ 232
Query: 1171 AQQQ------SRDKEVESLRMQLLDYQAQ-SDEKSLIAKLHQHNVSLQLSEATALGKLES 1223
Q R++E E L+ + Q+Q + ++ I++L A + +L+
Sbjct: 233 VQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQK 292
Query: 1224 ITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA-----KHLRQTI-------QSLR 1271
+ S + ++ N L + L +KEQ Y +LE ++ K+++ T+ Q L+
Sbjct: 293 LKSSVNELTQKNQTLTENLLKKEQD--YTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ 350
Query: 1272 RQFSGA--------LPLAQQ----EKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTL 1319
+ S + + L+++ +K + + +++ + E K QQ+ E L
Sbjct: 351 SRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGL 410
Query: 1320 EMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNII 1379
+++ ++ +L S L +T+ +++ H +++E R +L+ E + DKE+ +
Sbjct: 411 QLQSEIN---QLHSKLLETE--RQLGEAHGRLKEQR----QLSSEKLMDKEQQ------V 455
Query: 1380 SEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEAT 1439
++ + +S LEE++ ++ E Q D+ + + Q + ++ A E+
Sbjct: 456 ADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVL 515
Query: 1440 GSIPDPSLPLPNQLEIALRKIKENIRIILETR--------------ATCKSLEEK----- 1480
I D + N LE L+K KENI ++ + R A L+EK
Sbjct: 516 RQIGDKDQKIQN-LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQ 574
Query: 1481 ---------------------------LKEKESALRLAEQNILSRDKVINELRLRLPATA 1513
++E+++ LR A+ +LS + +NEL +L +
Sbjct: 575 EQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESK 634
Query: 1514 EREK-------------LIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
E+ L AE + + L A + + Q LN+ L +
Sbjct: 635 EKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVT 694
Query: 1561 RLLEKAREEQREI---VKKHEEDLHILHHRLE--------LQADSSLNKF--KQTAWDLM 1607
L+ +E ++ +K+++E L + E L+ADS K +Q DL
Sbjct: 695 AKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQ 754
Query: 1608 KQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLE-------RQREITEL 1660
+Q +R E+ + + + + +SS + L+K S+ LE +Q E ++
Sbjct: 755 QQRQLNTDLE---LRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQI 811
Query: 1661 KVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPT 1720
++FE + + + HE+ +++ V +L+ + + E + L +EL K+ S+
Sbjct: 812 LKQDFETLSQETKIQHEELNNRIQTTVTELQKV----KMEKEALMTELSTVKDKLSKVSD 867
Query: 1721 TTMRNLVERLKSQLALKEKQQKA----LSRALLELRAEMTAAAEERIISATSQKEAHLNV 1776
+ ++ KS+ + ++ KA L + EL+ ++ E + QKE ++
Sbjct: 868 S-----LKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL---KEQKELKKSL 919
Query: 1777 QQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKI 1836
++ + + +LK ++ + E L++ + LK ++ E L N+N+L ++K+K +
Sbjct: 920 EKEKEA-SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL 978
Query: 1837 LREKEEIDQENDELKRQI-KRLTSGLQGKPLTDNKQSLI----EELQRKVKKLENQLEGK 1891
E + + EL+ ++ ++LT Q K S++ E+ Q K+L++ G+
Sbjct: 979 QGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGR 1038
Query: 1892 VEEV-----DLKPMKEK--NAKEELIRWEEGKKWQAK-IEGIRNKLKEKEGEVFTLTKQL 1943
E+ DLK ++EK A+E+LI Q K I+ ++ E + +QL
Sbjct: 1039 ESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQL 1098
Query: 1944 NTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKEL----EELKKRNLDLEND 1999
KEK +++L + ++ I+ EKE+ EELK L+ +
Sbjct: 1099 QERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKC-RQEKEITKLNEELKSHKLESIKE 1157
Query: 2000 ILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQ 2059
I ++ + L L Q LQ K +L+ ++ ++ I D + E+
Sbjct: 1158 ITNLKDAKQL--------LIQQKLELQGKADSLKAAVEQEKRNQQ----ILKDQVKKEEE 1205
Query: 2060 ELQKE----NLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLG 2115
EL+KE KL SE E + +++ ++ +L Q+ L E +KKE QR++
Sbjct: 1206 ELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVS 1265
Query: 2116 HVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKA 2175
+ K +L I +++ V+ Q E L E+ E E EKL+
Sbjct: 1266 ELE------KQTDDLRGEIAVLEATVQNNQDERRAL--------LERCLKGEGEIEKLQT 1311
Query: 2176 ELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLR 2210
++ +L+ L ++ T +++ EN+ L+
Sbjct: 1312 KVLELQRKL--------DNTTAAVQELGRENQSLQ 1338
Score = 148 bits (374), Expect = 6e-35
Identities = 241/1136 (21%), Positives = 475/1136 (41%), Gaps = 168/1136 (14%)
Query: 1466 IILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRK 1525
++ ++ A +SLE++L+E ++ E + + K + E + AT IA++ K
Sbjct: 129 LVTDSSAELQSLEQQLEEAQT-----ENFNIKQMKDLFEQKAAQLATE-----IADIKSK 178
Query: 1526 EMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ-RLLEKAREEQREIVKKHEEDLHIL 1584
E +S + A Q + + LN++ V++ + LL++ E ++KK + L
Sbjct: 179 YDEERSLR--EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTL 236
Query: 1585 HHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF-IRLAEMEQTVAEQDDSLSSLLVK 1643
+ L+ + K K L Q + T LA+ Q VA L L
Sbjct: 237 MDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSS 296
Query: 1644 LKKVSQDLERQREITE-LKVKEFENIKLQLQENHEDEVKK-VKA-------EVEDLKYLL 1694
+ +++Q + + +TE L KE + KL+ + N E KK ++A + + L+ L
Sbjct: 297 VNELTQ---KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRL 353
Query: 1695 DQSQKESQCLKSELQAQKEANSRAPT--TTMRNLVERLKSQLALKEKQQKALSRALLELR 1752
S+ + EL + EA + + + + LK++ ++Q++ + L+L+
Sbjct: 354 SASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQ 413
Query: 1753 AEMTAAAEERIISATSQKEAHLNVQ---QIVDRHTRELKTQVEDLNENLLKLKEALKTSK 1809
+E+ + + + EAH ++ Q+ + + QV DL L +L+E LK
Sbjct: 414 SEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKV 473
Query: 1810 NRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDN 1869
L L+ + Q++Q + E + +++ RQI +Q N
Sbjct: 474 TNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQ------N 527
Query: 1870 KQSLIEELQRKVKKLENQLE--------GKVEEVDLKPMKEKN--AKEELIRWEEGKKWQ 1919
++L+++ + + LE + E G+ E L ++EKN +E++ + E K Q
Sbjct: 528 LEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQ 587
Query: 1920 AKI-----EGIRNKLKEK--------------EGEVFTLTKQLNTLKDLFAKAD-----K 1955
++ E + ++++E+ E V L QLN K+ ++ D K
Sbjct: 588 SESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAK 647
Query: 1956 EKLTLQRKLKTTGMTVDQVLGIRALES--EKELEELKK--RNLDLENDILYMRAHQALPR 2011
+L L + T D + ++ + + +EL K LD L +
Sbjct: 648 TELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQL 707
Query: 2012 DSVVEDLHLQNRYLQEKLHALEKQFSK--------DTYSKPSISGIESDDHCQREQELQ- 2062
+S +++ + L++K LE Q K + ++ ++ + EL+
Sbjct: 708 ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA 767
Query: 2063 ---KENLKLSSENIE-LKFQLEQANKDLPRLKNQVRDLKEMCEFLKK--EKAEVQRKLGH 2116
+ L++ E + + L++ ++ L +K ++ +E + LK+ E + K+ H
Sbjct: 768 TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827
Query: 2117 VRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKA- 2175
+ R T+ EL+K + ++ ++ ++L K S L + K + E+EN+K KA
Sbjct: 828 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSK-SEFEKENQKGKAA 886
Query: 2176 --ELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEIL 2233
+LEK L HQL + E+ K E + L+K L+KE +A+ +L++ N+++
Sbjct: 887 ILDLEKTCKELKHQLQVQMENTLK-------EQKELKKSLEKEKEASHQLKLELNSMQ-- 937
Query: 2234 NEKMTVQLEETGKRLQFAESRGPQLEG------ADSKSWKSIVVTRMYETKLKELE-TDI 2286
QL + L+ E QL+G S+ K + E K+ L+ T++
Sbjct: 938 -----EQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992
Query: 2287 AKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPE---GAETE-----QGLK 2338
K Q L Q +E ++K++ + E+ + K + G E+E Q LK
Sbjct: 993 ENKLQQ--QLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLK 1050
Query: 2339 RELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPD-----ADQLKEKIKDLETQLK 2393
+ L LA L + ++ +Q + ++ A++T+ QL+E+ K L+ K
Sbjct: 1051 SVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQK 1110
Query: 2394 MSDLEKQHL-----------------KEEIKKLKKELENFDPSFFEEI------------ 2424
L+++ L ++EI KL +EL++ +EI
Sbjct: 1111 EKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQ 1170
Query: 2425 ---------EDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEE 2471
+ LK ++E + +L+++VKK E+L E A E+E
Sbjct: 1171 QKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKE 1226
Score = 132 bits (331), Expect = 6e-30
Identities = 209/918 (22%), Positives = 401/918 (43%), Gaps = 143/918 (15%)
Query: 1627 EQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIK-LQLQENHEDE-VKKVK 1684
E +A + D ++ L +++ + L+ ++ +E KE E + LQ QE D V
Sbjct: 75 ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134
Query: 1685 AEVEDLKYLLDQSQKESQCLKS--ELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQK 1742
AE++ L+ L+++Q E+ +K +L QK A T + ++ + + +L+E ++
Sbjct: 135 AELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQL---ATEIADIKSKYDEERSLREAAEQ 191
Query: 1743 ALSRALLELRAEMTAAAEER--------IISATSQKEAHLNVQQIVDRHTRELKTQVEDL 1794
++R EL E T + + I K+ + VQ ++D T E + + E
Sbjct: 192 KVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESE-- 249
Query: 1795 NENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQI 1854
KLK+ K +++ S ++ L +EL K + ++E +++ +EL ++
Sbjct: 250 -----KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304
Query: 1855 KRLTSGLQGKPLTDNKQSLIEEL--QRKVKKLENQLEGKVEEVDLKPMKEKNAKEEL--- 1909
+ LT L K + + +EE + V K Q +++D + ++ + + E
Sbjct: 305 QTLTENLLKK---EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLH 361
Query: 1910 -IRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTG 1968
I E +K +A KLKE+ EV T + L KA+ ++L QR+ K
Sbjct: 362 RIHVELSEKGEAT-----QKLKEELSEVETKYQHL--------KAEFKQLQQQREEKEQ- 407
Query: 1969 MTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRY---- 2024
L+ + E+ +L + L+ E + AH L + L ++
Sbjct: 408 ---------HGLQLQSEINQLHSKLLETERQL--GEAHGRLKEQRQLSSEKLMDKEQQVA 456
Query: 2025 -LQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQAN 2083
LQ KL LE+Q + + + + D Q+ QE Q +++ E + LEQ
Sbjct: 457 DLQLKLSRLEEQLKEKVTNSTELQH-QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVL 515
Query: 2084 KDLPRLKNQVRDL-------KEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGL 2136
+ + ++++L KE L+KE+ ++ K+ G G + EK L
Sbjct: 516 RQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ--AGEGETAVLNQLQEKNHTL 573
Query: 2137 MKKVV---EKVQRENEQLKKASGIL-------------TSEKMANIEQENEKLKAELEKL 2180
++V EK++ ++E K+A L +++ ++E +L ++L +
Sbjct: 574 QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNES 633
Query: 2181 KAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQ 2240
K + QL + ++KT+ A R +L+ D A+ ++ + LN K+T Q
Sbjct: 634 KEKVS-QLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA--LQDKQQELN-KITTQ 689
Query: 2241 LEETGKRLQFAESRGPQLEGADSKSWKSIVV-----TRMYETKLKELETDI----AKKNQ 2291
L++ +LQ + QLE + K +K + T E ++K+LE D A K Q
Sbjct: 690 LDQVTAKLQDKQEHCSQLE-SHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQ 748
Query: 2292 SITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQL 2351
++ DL+Q + T+ E + + ++ LE + +I+ + T L+++ + L +L
Sbjct: 749 ALQDLQQQRQLNTDLELRATELSKQLEMEKEIV------SSTRLDLQKKSEALESIKQKL 802
Query: 2352 DKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHL-------KE 2404
K++ E QI ++ ++ T ++L +I+ T+L+ +EK+ L K+
Sbjct: 803 TKQEEE--KQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKD 860
Query: 2405 EIKKLKKELENFDPSFFEE-------IEDLKYNYKE-----------------EVKKNIL 2440
++ K+ L+N F +E I DL+ KE E+KK++
Sbjct: 861 KLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSL- 919
Query: 2441 LEEKVKKLSEQLGVELTS 2458
EK K+ S QL +EL S
Sbjct: 920 --EKEKEASHQLKLELNS 935
Score = 92.0 bits (227), Expect = 6e-18
Identities = 116/574 (20%), Positives = 262/574 (45%), Gaps = 56/574 (9%)
Query: 8 KEIMKVDPDDLPRQEELADNLLISLSKVEVN-ELKSEKQENVIHLFRITQSLMKMKAQEV 66
KEI+ DL ++ E +++ L+K E ++ + E + +I + + Q
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTT 837
Query: 67 ELALEEVEKAGEEQAKFENQLKTKVMKLENEL-----EMAQQSAGGRDTRFLRNEIC--- 118
L++V+ E + +K K+ K+ + L E +++ G+ + C
Sbjct: 838 VTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKEL 897
Query: 119 --QLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQL 176
QL+ Q+E +E ++++K LEKEK+ + QL L + + + + K+ +K+ +QL
Sbjct: 898 KHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL 957
Query: 177 CQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDE-IQTLTEANEKIEVQ 235
+I + ++ + +K+ + + +GE Q ++ +L Q L + Q L EKI V
Sbjct: 958 QGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISV- 1016
Query: 236 NQEMRKNLEESVQEMEKM-TDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKS 294
++ N E+S + +++ +D Y R ++ + LK + L + DL+ +
Sbjct: 1017 ---LQNNYEKSQETFKQLQSDFYGRESELLATRQD----LKSVEEKLSLAQE---DLISN 1066
Query: 295 KNEEDDPIMVAVNAKVEEWKLILSS--KDDEIIEYQQMLHNLREK--LKNAQLDADKSNV 350
+N+ + + K + L S K+ ++ E + L +++++ LK +L +KS +
Sbjct: 1067 RNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKL 1126
Query: 351 MALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQ 410
+++ ++ +I L E+++ + E K E+ K A L Q +++Q
Sbjct: 1127 AEIEEIKCRQEKEITKLNEELKSHKLESIK----------EITNLKDAKQLLIQQKLELQ 1176
Query: 411 STLDILKEKTKEAERTAELAEADAREKDKELVEAL--------KRLKDYESGVYGLEDAV 462
D LK ++ +R ++ + +++++EL + +K+ E G+ E+
Sbjct: 1177 GKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENE 1236
Query: 463 VEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRN 522
++ QI + + + KE + ++S+ + + LR + + T+ + + R
Sbjct: 1237 AKL---TMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERR 1293
Query: 523 SKHLKQQQYRAENQILLKEIESLEEERLDLKKKI 556
+ L ++ + E EIE L+ + L+L++K+
Sbjct: 1294 A--LLERCLKGEG-----EIEKLQTKVLELQRKL 1320
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 186 bits (471), Expect = 3e-46
Identities = 356/1813 (19%), Positives = 731/1813 (40%), Gaps = 207/1813 (11%)
Query: 8 KEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVE 67
KE K+ ++ RQ EL + L K+E EL+ E+QE R+ + + QE E
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEE-QLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEE 313
Query: 68 LALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQK 127
E+ E+ E+Q + E Q + + +L E E ++ R+ R E Q ++
Sbjct: 314 RR-EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERRE------QQLRR 366
Query: 128 DRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQI 187
++E E E++L +E+++ + LR E+ +LRRE ++L+++ + + + ++Q+
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE-QQLRREQQLRREQQLRREQQL 425
Query: 188 DSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESV 247
++E + + + R Q K+ E E + + E+ E QE RK
Sbjct: 426 RREQEEERHEQKHEQERREQRLKREQE------ERRDWLKREEETERHEQERRK------ 473
Query: 248 QEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVN 307
Q++++ +E R + + + + +Q ++ + + +E + + EE++ + +
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Query: 308 AKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKML 367
++ + L + +E +Q+L EK +L+ ++ ++ + RD +K
Sbjct: 534 SEQQ-----LRREQEE--RREQLLKREEEK----RLEQERREQRLKREQEERRDQLLKRE 582
Query: 368 TEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTA 427
E+ +Q K ++ E L+ L+R + L Q+ + + LK + E ER
Sbjct: 583 EERRQQRLKREQE-----ERLEQRLKREE-VERLEQEERREQR-----LKREEPEEERRQ 631
Query: 428 ELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEIN 487
+L +++ +E+ ++ ++ + E + E+ + K + + RE E+ +E
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691
Query: 488 KLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEE 547
+ +I + + + E ++ + + ++Q+ + + E++ EE
Sbjct: 692 QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751
Query: 548 ERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQS 607
ER RQ +E +R T E+ + R R+ L+ Q
Sbjct: 752 ERAH-----RQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR 806
Query: 608 KNEFL-SRELIEKERDLERSRTVIAKF-----QNKLKELVEENKQLEEGMKEILQAIKEM 661
+ FL E E+ R R R +F Q + +E ++ ++ E+G++E + +
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQ 866
Query: 662 QKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRE 721
++ D K + +R + + +K A L+ + L EEL++E RE
Sbjct: 867 EQRRDQKW--RWQLEEERKRRRHTLYAKPA-----LQEQLRKEQQLLQEEEEELQREERE 919
Query: 722 SRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQN 781
R+ Q + L+ ++E LLR+
Sbjct: 920 KRRRQEQERQYREEEQLQ----QEEEQLLREEREK------------------------- 950
Query: 782 EYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIK 841
QE E + +K K L+ E + R +Q K+Y E+E + E + ++
Sbjct: 951 ----RRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE-REKKYREEEELQQEEEQLLR 1005
Query: 842 EEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKI---TVLQVNEKSLI- 897
EE+ K Q + + K+ + + K+ L E R+ LQ E+ L+
Sbjct: 1006 EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065
Query: 898 --RQYTTLVELERQLRKENEKQKNE--LLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953
R+ ELERQ RKE E Q+ E LL E E +R ++ + +++
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPE--------KRRRQERERQCREEEELQ 1117
Query: 954 DNSVSLSELELANKQYNELTAKYR---DILQKDNMLVQRTSNLEHLECENISLKEQVESI 1010
L E ++ EL +YR ++ Q++ L++ + +E+ E
Sbjct: 1118 QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQ 1177
Query: 1011 NKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNER 1070
+E ++ +E+ Q E++ + E K K+ + D S K KE R
Sbjct: 1178 QEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRS-DLKWQWEPEKENAVR 1236
Query: 1071 QRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAV 1130
+C+ L+ + R+ + + L + + ++ R + D
Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEE 1296
Query: 1131 SDADRQRILELEKNEMELKVEVSKLREISDIARRQVE----ILNAQQQSRDKEVESLRMQ 1186
+R+ E ++ + + + E LRE + RR+ E +Q +++E + LR Q
Sbjct: 1297 EQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ 1356
Query: 1187 LLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKL--DE 1244
D + + +E HQ L E L + Q+ E L+ EQ+L E
Sbjct: 1357 ERDRKFREEELR-----HQEQGRKFLEEEQRL--------RRQERERKFLKEEQQLRCQE 1403
Query: 1245 KEQALYYAR----------LEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQ 1294
+EQ L R L + R + R+ Q +RRQ L ++++ + +
Sbjct: 1404 REQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKF 1463
Query: 1295 NDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEEL 1354
++ +++QE + Q + + K LE E +L+ E +D K + +EL
Sbjct: 1464 REEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE------RDRK---------FREQEL 1508
Query: 1355 RLQE-----LKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQ 1409
R QE L+ ++L + + + K+L + R + + KF EE Q+ ++
Sbjct: 1509 RSQEPERKFLEEEQQLHRQQRQRKFLQE-EQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567
Query: 1410 REVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILE 1469
E L RQ DR+ ++ E+ + D + ++ ++ ++ +R
Sbjct: 1568 EEQQLSRQER--DRKFRLEEQKVRRQEQERKFMED-------EQQLRRQEGQQQLR---- 1614
Query: 1470 TRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEP 1529
+ + K +E E L+ E+ L R + + P +L R+E E
Sbjct: 1615 -----QERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEP----------QLRRQEREQ 1659
Query: 1530 KSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLE 1589
+ H + + L + EE + Q K REE++++ ++ E + L +
Sbjct: 1660 QLRHD---RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL-RRQERERKFLQEEQQ 1715
Query: 1590 LQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQ 1649
L+ KF++ + + + + ++ E EQ E+++ + +K +
Sbjct: 1716 LRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775
Query: 1650 D--LERQREITELKVKEFE-NIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKS 1706
+ L ++RE +L+ +E + + + Q E E ++++ + D KY ++ Q + + +
Sbjct: 1776 EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835
Query: 1707 ELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISA 1766
L+ +++ RA R + Q +E++QK +LR EE I
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLR-------EEHIRRQ 1888
Query: 1767 TSQKEAHLNVQQI 1779
+++ H V +I
Sbjct: 1889 QKEEQRHRQVGEI 1901
Score = 175 bits (444), Expect = 4e-43
Identities = 373/1941 (19%), Positives = 804/1941 (41%), Gaps = 250/1941 (12%)
Query: 121 EKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDI 180
+++ E +DR+LE+ + ++K+ ++ L E ++E + R E + ++++E+L +
Sbjct: 119 QRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQE-RLEQRDRQRRDEELWRQR 177
Query: 181 IDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQ----TLTEANEKIEVQN 236
++Q++ + RR E+ + S K +E ++ DE Q L E K +
Sbjct: 178 QEWQEREE--------RRAEEEQLQ---SCKGHETEEFPDEEQLRRRELLELRRKGREEK 226
Query: 237 QEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKN 296
Q+ R+ ++ V + E+ E+ + + ++ + + ++L++E Q ++QE + L+
Sbjct: 227 QQQRRERQDRVFQ-EEEEKEWRKRETVLRKEE---EKLQEEEPQRQRELQEEEEQLRKLE 282
Query: 297 EEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQG 356
++ + + +E + + + +Q L +E+ + Q + + +Q
Sbjct: 283 RQE------LRRERQE-----EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQ 331
Query: 357 IQERDSQIKM-LTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTL-- 413
+ R+ Q++ E+ EQ + ++ + L+ E + + L ++ ++ + L
Sbjct: 332 EERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRR 391
Query: 414 --DILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQ 471
+ +E+ E+ + RE+ + L+R ++ E E E + + Q
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451
Query: 472 IKIRD-----REIEILTKEINKLELKISDFLDENEALRER-VGLEPKTMIDLTEFRNSKH 525
+ RD E E +E K +LK D+ E RER + LE + + E R +
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLK----RDQEEERRERWLKLEEEERREQQERREQQL 507
Query: 526 LKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQ 585
++Q+ R E ++ +E E ++RL ++++R+ +ER ++ L E+ E +
Sbjct: 508 RREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL----LKREEEKRLEQERR 563
Query: 586 GDRISERKLDLLSLKNMSEAQSKNEFLSRELIEK-ERDLERSRTVIAKFQNKLKELVEEN 644
R+ + + E + + + L RE E+ E+ L+R + + + ++ ++
Sbjct: 564 EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKRE 623
Query: 645 KQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQ 704
+ EE +++L++ ++ ++ + L ER ++ + E + L + +
Sbjct: 624 EPEEERRQQLLKSEEQEER------RQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677
Query: 705 VDQLTGRNEELRQELRESRKEAINYSQQLAKANLKID-----HLEKETSLLRQSEGSNVV 759
++ R +EL +E +E +E I ++ K +++ K S R+ EG
Sbjct: 678 EER---REQELAEEEQEQARERI--KSRIPKWQWQLESEADARQSKVYSRPRKQEGQ--- 729
Query: 760 FKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEK-----------------KLKNLE 802
+ + S + Q E H Q+ E + + +L
Sbjct: 730 -RRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP 788
Query: 803 DSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYN 862
E R+ QQ + +L E+E + + +E +++L+ +++ ++ +E
Sbjct: 789 PLREQRERQLRAEERQQR--EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERA 846
Query: 863 NLL----NALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVE--LERQLRKENEK 916
L + LQ D + + +K Q+ E+ R++T + L+ QLRKE +
Sbjct: 847 QQLQEEEDGLQEDQERRRSQEQRRDQKWR-WQLEEERKRRRHTLYAKPALQEQLRKEQQL 905
Query: 917 QKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKY 976
+ E ++ E EK R ++ + +++ L E ++ E +Y
Sbjct: 906 LQEEEEELQREEREK-----RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960
Query: 977 RDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGN 1036
R KD L Q+ L E E +E+ + +E E+ +E+ + + E+E +
Sbjct: 961 R----KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE--EREKRRRQ 1014
Query: 1037 ESSMDKAKKSITNSDIVSISKKITMLEMKELNERQR----AEHCQKMYEHLRTSLKQMEE 1092
E KK + + ++ E + L ER+R E Q+ E L ++
Sbjct: 1015 EWERQYRKKDELQQEEEQLLRE--EREKRRLQERERQYREEEELQQEEEQLLGEERETRR 1072
Query: 1093 RNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELE---KNEMELK 1149
R ELE ++ + ++ Q+ EQ+LR+E +++R E E + E EL+
Sbjct: 1073 RQ-ELERQYRKEEELQ---QEEEQLLREE-----------PEKRRRQERERQCREEEELQ 1117
Query: 1150 VEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVS 1209
E +L RR+ E+ +Q ++EV+ QLL + + + + + ++
Sbjct: 1118 QEEEQLLREEREKRRRQEL--ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE-- 1173
Query: 1210 LQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQS 1269
+LQ+ E LR EQ+ +E+ Y E R K ++
Sbjct: 1174 ----------------EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR---- 1213
Query: 1270 LRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMK-----NSQQEHRNMENKTLEMELK 1324
+++ S Q + +K +++ K ++ R +E+ L
Sbjct: 1214 ----------YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQS 1263
Query: 1325 LKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYER 1384
+ L+ L+ ++ Q+ W + +E +L RE +++E K + E ++
Sbjct: 1264 QQDLQHLLGEQQERDREQERRRWQQRDRHFP-EEEQLERE---EQKEAKRRDRKSQEEKQ 1319
Query: 1385 TISSLEEEIVQQ----NKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG 1440
+ EE ++ KF EE Q+ ++ E L RQ +KF E
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQ------------ERDRKFREEEL 1367
Query: 1441 SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK 1500
+ + + R+ +E + E + C+ E++L++ E+ LSR +
Sbjct: 1368 RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQE 1427
Query: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
+ R E E+ ++ R+E E K L+ Q + ++E++L++
Sbjct: 1428 RDRKFR-------EEEQ---QVRRQERERK---FLEEEQQLRQERHRKFREEEQLLQE-- 1472
Query: 1561 RLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF 1620
REEQ+ + + E D L +L+ KF++ +L Q P +
Sbjct: 1473 ------REEQQ--LHRQERDRKFLEEEQQLRRQERDRKFREQ--ELRSQEPERKFLEEEQ 1522
Query: 1621 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHED-- 1678
+ Q Q++ + ++ QD +R+ E +E E +L QE
Sbjct: 1523 QLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFR 1582
Query: 1679 -EVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALK 1737
E +KV+ + ++ K++ D+ Q Q + +L+ +++ R ++ ER + QL +
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQ---EREEQQLHRQ 1639
Query: 1738 EKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNEN 1797
E+ +K L EE ++E L + DR RE + +++ E
Sbjct: 1640 ERDRKFL---------------EEEPQLRRQEREQQLRHDR--DRKFREEEQLLQEGEEQ 1682
Query: 1798 LLKLKEALKTSKNRENSLTDNLND---LNNELQKKQKAYNKILREKEEIDQ--ENDELKR 1852
L+ +E + + E L + L E Q +++ + RE+E++ Q E ++L+R
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRR 1742
Query: 1853 Q--IKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMK--EKNAKEE 1908
Q +++ Q +P + +Q +E RK ++ E QL + EE L+ + K +EE
Sbjct: 1743 QERYRKILEEEQLRPEREEQQLRRQERDRKFRE-EEQLRQEREEQQLRSQESDRKFREEE 1801
Query: 1909 LIRWE-EGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTT 1967
+R E E ++ + + + + +E++ ++ ++L +D +A+++ T ++ +
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE 1861
Query: 1968 GMTVDQVLGIRALESEKELEE 1988
+ R E E++L E
Sbjct: 1862 QELWQEEEQKRRQERERKLRE 1882
Score = 172 bits (436), Expect = 4e-42
Identities = 400/1935 (20%), Positives = 778/1935 (40%), Gaps = 268/1935 (13%)
Query: 60 KMKAQEVELALEEVEKAGEEQAKFENQLKTK------------VMKLENELEMAQ-QSAG 106
+ K QE E L E E+ E+Q + E + + + + E E Q QS
Sbjct: 138 RQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK 197
Query: 107 GRDT-------RFLRNEICQL------EKQLEQKDRE----LEDMEKELEK--------E 141
G +T + R E+ +L EKQ ++++R+ E+ EKE K E
Sbjct: 198 GHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEE 257
Query: 142 KKVNEQLALRNEEAENENSKLRR----ENKRLKKKNEQLCQDIIDYQ----KQIDSQKET 193
+K+ E+ R E + E +LR+ E +R +++ EQ Q + Q KQ + ++E
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ 317
Query: 194 LLSRRGEDSDYRSQLSKKNYELIQYLDE--IQTLTEANEKIEVQNQEMRKNLEESVQEME 251
RR + Q ++ +L + +E Q L E+ E + Q++R+ EE +E +
Sbjct: 318 QEERREQQERREQQEERREQQLRREQEERREQQLRREQEE-ERREQQLRREQEEERREQQ 376
Query: 252 KMTDEYNRMKAIVHQTDNV--IDQLKKEND-------HYQLQVQELTDLLKSKNEEDDPI 302
++ R + + + + QL++E + Q++ L + + EE
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436
Query: 303 MVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDS 362
+ + K + D + ++ + +E+ K QL D QE +
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQ-QLKRD-----------QEEER 484
Query: 363 QIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKE 422
+ + L + E+ ++ E+ + L+ E + + Q+ ++Q L ++ +E
Sbjct: 485 RERWLKLEEEERREQQERRE---QQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRRE 541
Query: 423 AERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEIL 482
E E EK E +RLK + D +++ + + Q +++ + E L
Sbjct: 542 QEERREQLLKREEEKRLEQERREQRLKREQE---ERRDQLLKREEERRQQRLKREQEERL 598
Query: 483 TKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEI 542
+ + + E++ + + E +R E + L + + +QQQ R E Q ++
Sbjct: 599 EQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR 658
Query: 543 ESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISER------KLDL 596
EEE L++++++ +E + ++L E +RI R +L+
Sbjct: 659 LKREEEEERLEQRLKREHEEERRE--------QELAEEEQEQARERIKSRIPKWQWQLES 710
Query: 597 LSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQ 656
+ S+ S+ + +E++ E+ R ++ Q + +E +Q EE ++
Sbjct: 711 EADARQSKVYSRPRKQEGQRRRQEQE-EKRRRRESELQWQEEERAHRQQQEEEQRRDFTW 769
Query: 657 AIKEMQKDPDVKGGETSLIIPSL----ERLVNAIESKNAEGIFDASLHLKAQVDQLTGRN 712
+ +K +G + P L ER + A E + E F K
Sbjct: 770 QWQAEEKSE--RGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEK---------- 817
Query: 713 EELRQELRESRKEA--INYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIA 770
E+ R++ RE KE + +QL + E+E L E + D
Sbjct: 818 EQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQ 877
Query: 771 PSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEK 830
Y LQE KE++L L++ E+ R+ R +Q ++Y E+
Sbjct: 878 LEEERKRRRHTLYAKPALQEQLRKEQQL--LQEEEEELQREEREKRRRQE-QERQYREEE 934
Query: 831 ETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKI---T 887
+ + E + ++EE+ K Q ++ + + + + K+ E +K
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE 994
Query: 888 VLQVNEKSLIRQYTTLVELERQLRKENEKQ---KNELLSMEAEVCEKIGCLQRFKEMAIF 944
LQ E+ L+R+ E E++ R+E E+Q K+EL E ++ + +R +E
Sbjct: 995 ELQQEEEQLLRE-----EREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERE-R 1048
Query: 945 KIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLK 1004
+ +++ L E ++ EL +YR K+ L Q L E E +
Sbjct: 1049 QYREEEELQQEEEQLLGEERETRRRQELERQYR----KEEELQQEEEQLLREEPEKRRRQ 1104
Query: 1005 EQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEM 1064
E+ +E E+ +E+ + + E+E + E ++ + + ++
Sbjct: 1105 ERERQCREEEELQQEEEQLLRE--EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR 1162
Query: 1065 KELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELAD 1124
++ ERQ E + E + ++ E+R E E ++ E + L QK +Q RDE
Sbjct: 1163 RQELERQYREEEELQQEEEQLLREEQEKRRQERERQYRE--EEELQRQKRKQRYRDEDQR 1220
Query: 1125 SVSKAVSDADRQRILELEK-------NEMELKVEVSKLREISDIARRQVEILNAQQQSRD 1177
S K + +++ + K NE ++E S+LR+ +++ ++ L +QQ RD
Sbjct: 1221 SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ--SQQDLQHLLGEQQERD 1278
Query: 1178 KEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLR 1237
+E E R Q D +E +LE K K R
Sbjct: 1279 REQERRRWQQRDRHFPEEE-----------------------QLEREEQKEAK------R 1309
Query: 1238 LEQKLDEKEQALYYARLEGRNRA---KHLRQTIQSLRRQFSGALPLAQQE---KFSKTMI 1291
++K E++Q L R E R R + R+ Q L+ + PL +QE KF + +
Sbjct: 1310 RDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQER--EEQPLRRQERDRKFREEEL 1367
Query: 1292 QLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKI 1351
+ Q K ++E + +++ R + E +L+ + E+ + +D K +
Sbjct: 1368 RHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK---------FRE 1418
Query: 1352 EELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQ--NKFHEERQMAWDQ 1409
EE +L + +R+ +++++++ E ER E+++ Q+ KF EE Q+ ++
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRR-----QERERKFLEEEQQLRQERHRKFREEEQLLQER 1473
Query: 1410 REVDLERQ----LDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIR 1465
E L RQ + + QQ +KF E +P RK E
Sbjct: 1474 EEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPE-----------RKFLEE-- 1520
Query: 1466 IILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRK 1525
E + + + K ++E LR E+ R + R ERE+ +L R+
Sbjct: 1521 ---EQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREE--QQLSRQ 1575
Query: 1526 EMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQ--REIVKKHEEDLHI 1583
E + K ++ Q + R Q+ + ++ Q+L + ++Q +E +K ED +
Sbjct: 1576 ERDRK----FRLEEQKV----RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627
Query: 1584 LHHRLE--LQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLL 1641
L R E L KF + L +Q + + E EQ + E ++
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQ----- 1682
Query: 1642 VKLKKVSQDLERQREITELKVKEFENIKLQ-LQENHEDEVKKVKAEVEDLKYLLDQSQKE 1700
+L++ +D + + E +L+ +E E LQ Q+ E+++ E E L+ +Q Q
Sbjct: 1683 -QLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLR 1741
Query: 1701 SQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAE 1760
Q ++ +++ ER + QL +E+ +K L E E
Sbjct: 1742 RQERYRKILEEEQLRP-----------EREEQQLRRQERDRKFREEEQLRQERE-----E 1785
Query: 1761 ERIISATSQKEAHLNVQQIVDRHTRELKTQVED----LNENLLKLKEALKTSKNRENSLT 1816
+++ S S ++ Q +R ++L+ Q D E L+L+E +E L
Sbjct: 1786 QQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEE-------QEQRLR 1838
Query: 1817 DNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEE 1876
D +++ K RE++E+ QE ++ +RQ + L+ + + +Q E+
Sbjct: 1839 QE-RDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERE--RKLREEHI--RRQQKEEQ 1893
Query: 1877 LQRKVKKLENQLEGK 1891
R+V ++++Q EGK
Sbjct: 1894 RHRQVGEIKSQ-EGK 1907
Score = 149 bits (376), Expect = 3e-35
Identities = 270/1281 (21%), Positives = 540/1281 (42%), Gaps = 119/1281 (9%)
Query: 1237 RLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQND 1296
R QK E+E+ L EG +++ + Q R++ L +QE + + + +
Sbjct: 136 RRRQKRQEQEREL----AEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEE 191
Query: 1297 KLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRL 1356
+L+ + + + + +EL+ KG EE + + Q + + +E R
Sbjct: 192 QLQSCKGHETEEFPDEEQLRRRELLELRRKGREE---KQQQRRERQDRVFQEEEEKEWRK 248
Query: 1357 QELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLER 1416
+E L +E K +EE + E E + LE + +++ + EE+Q +RE L R
Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR 308
Query: 1417 QLDIFDRQQNEILNAAQKFEEATGSIPDPSL--PLPNQLEIALRKIKENIRIILETRATC 1474
+ + R+Q E Q+ E + L + E LR+ +E E R
Sbjct: 309 KQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEE-----ERREQQ 363
Query: 1475 KSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHT 1534
E++ + +E LR EQ + ++ E +LR RE+ + R+E + +
Sbjct: 364 LRREQEEERREQQLR-REQQLRREQQLRREQQLRREQQLRREQQL----RREQQLRREQQ 418
Query: 1535 LKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADS 1594
L+ Q + ++++ ++ ++ L++ +EE+R+ +K+ EE R + Q
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478
Query: 1595 SLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQ----DDSLSSLLVKLKKVSQD 1650
+ ++ W +++ + +L ++ EQ + L +L+ Q
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Query: 1651 LERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQA 1710
Q E E +K E +L+ QE E +K+ + E D + L + ++ Q LK E +
Sbjct: 539 RREQEERREQLLKREEEKRLE-QERREQRLKREQEERRD-QLLKREEERRQQRLKREQEE 596
Query: 1711 QKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQK 1770
+ E + R VERL+ + E++++ L R E EER +
Sbjct: 597 RLEQRLK------REEVERLEQE----ERREQRLKREEPE---------EERRQQLLKSE 637
Query: 1771 EAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQ 1830
E QQ + R +E + Q E +L++ LK RE+ +L E Q++
Sbjct: 638 EQEERRQQQLRREQQERREQRLKREEEEERLEQRLK----REHEEERREQELAEEEQEQA 693
Query: 1831 KAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEG 1890
+ R K I + +L+ + S + +P Q +E + K ++ E++L+
Sbjct: 694 RE-----RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW 748
Query: 1891 KVEEVDLKPMKEKNAKEELIRWEEGKKWQA--KIEGIRNKL-------KEKEGEVFTLTK 1941
+ EE + +E+ + + W+ WQA K E R +L +++E ++ +
Sbjct: 749 QEEERAHRQQQEEEQRRD-FTWQ----WQAEEKSERGRQRLSARPPLREQRERQLRAEER 803
Query: 1942 QLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKK-RNLDLENDI 2000
Q + L + +KE+ QR+ ++ ++ LE E++L+ ++ + L E D
Sbjct: 804 QQREQRFLPEEEEKEQRRRQRR--------EREKELQFLEEEEQLQRRERAQQLQEEEDG 855
Query: 2001 LY----MRAHQALPRDS----VVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESD 2052
L R Q RD +E+ + R+ AL++Q K+ E +
Sbjct: 856 LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ-----EEE 910
Query: 2053 DHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQR 2112
+ QRE E +K + + QL+Q + L R + + R +E +K+K ++Q+
Sbjct: 911 EELQRE-EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDK-KLQQ 968
Query: 2113 KLGHVRGSGRSGKTIPELEKTI----GLMKKVVEKVQRENEQLKKASGILTSEKMANIEQ 2168
K + G + E EK L ++ + ++ E E+ ++ K ++Q
Sbjct: 969 KEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ 1028
Query: 2169 ENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKN 2228
E E+L E E+ K L + E + + E++ E E+L E ++ E R +
Sbjct: 1029 EEEQLLRE-EREKRRLQER-----ERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082
Query: 2229 NLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAK 2288
E+ E+ + EE KR + R + E + + ++ + + +ELE +
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYRE 1142
Query: 2289 KNQSITDLKQLVKEATE---REQKVNKYNEDLE---QQIKILKHVPE--GAETEQGLKRE 2340
+ + + +QL++E E R++ +Y E+ E ++ ++L+ E E E+ + E
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202
Query: 2341 LQVLRLANHQL---DKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLE-TQL--KM 2394
++ R Q + ++++L Q E K+ + ++ + + E+ + LE +QL +
Sbjct: 1203 EELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ 1262
Query: 2395 SDLEKQHLKEEIKKLKKELE----NFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSE 2450
S + QHL E ++ +E E F E E L+ ++E K+ ++ K+L
Sbjct: 1263 SQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLR 1322
Query: 2451 QLGVELTSPVAASEEFEDEEE 2471
+ E +F +EE+
Sbjct: 1323 EEREEKRRRQETDRKFREEEQ 1343
Score = 146 bits (369), Expect = 2e-34
Identities = 351/1769 (19%), Positives = 713/1769 (40%), Gaps = 261/1769 (14%)
Query: 789 QELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLE 848
Q+ + +E++L E+ E R R ++ +E +++ W+ +EE+R E
Sbjct: 139 QKRQEQERELAEGEEQSEKQERLEQRDRQRRD---EELWRQRQEWQE-----REERRAEE 190
Query: 849 DQVQQDAIKVKEYNNLLNALQMDSDEM---------KKILAENSRKITVLQVNEKSLIRQ 899
+Q+Q + K E + Q+ E+ +K R+ V Q E+ R+
Sbjct: 191 EQLQ--SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248
Query: 900 YTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSL 959
T++ E + +E E Q+ L E E K L
Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQLRK---------------------------L 281
Query: 960 SELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKE 1019
EL ++ E + R L+++ L R E + +EQ E ++ E ++
Sbjct: 282 ERQELRRERQEEEQQQQR--LRREQQL--RRKQEEERREQQEERREQQERREQQEERREQ 337
Query: 1020 KLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKM 1079
+L EQ +E +L E ++ ++ +++ E +R E +
Sbjct: 338 QLRR-EQEERREQQLRREQEEERREQ-----------------QLRREQEEERREQQLRR 379
Query: 1080 YEHLRTSLKQMEERNFELETKFAELTKINLDAQ-KVEQMLRDELADSVSKAVSDADRQRI 1138
+ LR + E+ E + ++ + Q + EQ LR E + + + ++
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE--QQLRREQEEERHEQK 437
Query: 1139 LELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKS 1198
E E+ E LK E + R D +R+ E +Q+ R ++++ D + + E+
Sbjct: 438 HEQERREQRLKREQEERR---DWLKREEETERHEQERRKQQLKR------DQEEERRERW 488
Query: 1199 LIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRN 1258
L + + + E + E + K + RL+Q+L ++Q R E
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL----RREQEE 544
Query: 1259 RAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKT 1318
R + L L+R+ L ++E+ K + + D+L +E + Q+ R E +
Sbjct: 545 RREQL------LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER- 597
Query: 1319 LEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNI 1378
LE LK + +E L E+ +E +L RE +++ + L +
Sbjct: 598 LEQRLKREEVERL--------------------EQEERREQRLKREEPEEERRQQLLKSE 637
Query: 1379 ISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIF---DRQQNEILNAAQKF 1435
E R ++++ ++ + E+++ ++ E LE++L +R++ E+ Q+
Sbjct: 638 EQEERR-----QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQ 692
Query: 1436 --EEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQ 1493
E IP L ++ + K+ R E + + EEK + +ES L+ E+
Sbjct: 693 ARERIKSRIPKWQWQLESEADARQSKVYSRPRK-QEGQRRRQEQEEKRRRRESELQWQEE 751
Query: 1494 NILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKE 1553
R + E R + E+ +E GR+ + A + + R + E
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQAEEK-SERGRQRLS---------ARPPLREQRERQLRAE 801
Query: 1554 EVLKKYQRLL--EKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLM---- 1607
E ++ QR L E+ +E++R ++ E++L L +LQ + ++ L
Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861
Query: 1608 -KQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFE 1666
++S K +L E + + +L +L+K Q L+ + E EL+ +E E
Sbjct: 862 RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE--ELQREERE 919
Query: 1667 NIKLQLQENHEDEVKKVKAEVEDL----KYLLDQSQKESQCLKSELQAQKEANSRAPTTT 1722
+ Q QE E ++++ E E L + + ++E Q K + QKE
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979
Query: 1723 MRNLVERLKS------------QLALKEKQQKALSRALLELRAEMTAAAEERIISATSQK 1770
R ER K QL +E++++ + R + EE + ++
Sbjct: 980 KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREERE 1039
Query: 1771 EAHLNVQQIVDRHTRELKTQVEDL--NENLLKLKEALKTSKNRENSLTDNLNDLNNELQK 1828
+ L ++ R EL+ + E L E + ++ L+ +E L L E +
Sbjct: 1040 KRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPE 1099
Query: 1829 KQKAYNKI--LREKEEIDQENDELKRQI--KRLTSGLQGK-----PLTDNKQSLIEELQR 1879
K++ + RE+EE+ QE ++L R+ KR L+ + + ++ L+ E
Sbjct: 1100 KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE 1159
Query: 1880 KVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNK---LKEKEGEV 1936
K ++ E + + + EE + + +E+L+R E+ K+ Q + R + ++K +
Sbjct: 1160 KRRRQELERQYREEE------ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQR 1213
Query: 1937 FTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDL 1996
+ Q + LK + + +KE K+ G R E ++LE+ + R+
Sbjct: 1214 YRDEDQRSDLKWQW-EPEKENAVRDNKVYCKG---------RENEQFRQLEDSQLRDRQS 1263
Query: 1997 ENDILYMRAHQALPRDSVVEDLHLQ--NRYLQEKLHALEKQFSKDTYSKPSISGIESDDH 2054
+ D+ ++ Q RD E Q +R+ E+ LE++ K+ + S + +
Sbjct: 1264 QQDLQHLLGEQQ-ERDREQERRRWQQRDRHFPEE-EQLEREEQKEAKRRDRKS--QEEKQ 1319
Query: 2055 CQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCE----------FLK 2104
RE+ +K + + + QL Q ++ P L+ Q RD K E FL+
Sbjct: 1320 LLREEREEKRRRQETDRKFREEEQLLQEREEQP-LRRQERDRKFREEELRHQEQGRKFLE 1378
Query: 2105 KE----KAEVQRKL----GHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASG 2156
+E + E +RK +R R + + ++ ++ + + +R+ + ++
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQ 1438
Query: 2157 ILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYES----KTKGTEKIIAENERLRKE 2212
+ E+ +E ++L+ E + K QL E + + K + E ++LR++
Sbjct: 1439 VRRQERERKFLEEEQQLRQERHR-KFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ 1497
Query: 2213 LKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAES------RGPQLEGADSKSW 2266
+ ++LR + + L E+ + ++ ++ E RG Q + +
Sbjct: 1498 ERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKF 1557
Query: 2267 KSIVVTRMY--ETKLKELETD---------IAKKNQS---ITDLKQLVKEATE---REQK 2309
+ R E +L E D + ++ Q + D +QL ++ + R+++
Sbjct: 1558 REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER 1617
Query: 2310 VNKYNEDL-------EQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQI 2362
K+ ED EQQ+ + + E E L+R+ + +L H D++ E
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL-RHDRDRKFRE----- 1671
Query: 2363 EANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFE 2422
E Q G E + ++ K ++ E QL+ + E++ L+EE + ++ELE F
Sbjct: 1672 EEQLLQEGEEQQLRRQER-DRKFREEEQQLRRQERERKFLQEEQQLRRQELER----KFR 1726
Query: 2423 EIEDLKYNYKEEVKKNILLEEKVKKLSEQ 2451
E E L+ +E ++ + +E+ +K+ E+
Sbjct: 1727 EEEQLR---QETEQEQLRRQERYRKILEE 1752
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 185 bits (469), Expect = 5e-46
Identities = 311/1536 (20%), Positives = 668/1536 (43%), Gaps = 193/1536 (12%)
Query: 9 EIMKVDPDDLPRQEELADNLLISLSKVEVNEL------KSEKQENVIHLFRITQ-SLMKM 61
E K+ P + + + + + I V E+ S+ + ++ L + Q + +
Sbjct: 356 ECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAE 415
Query: 62 KAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLE 121
++++ +E +EK ++ + +L+ ++KL NE E+ + +A RD L +E+ L
Sbjct: 416 DNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTAT-RDIS-LDSELHDLR 473
Query: 122 KQLEQKDREL--------------EDMEKELEKEKK----VNEQLALRNEEAENENSKLR 163
LE K++EL E+++++ ++ K + +QL+ + E ++ SKL+
Sbjct: 474 LNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLK 533
Query: 164 RENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQ 223
++ KK+ QL D +D K++D QKE L+ +D K ++ +D++
Sbjct: 534 QDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLN 593
Query: 224 TLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTD-NVIDQLKKENDHYQ 282
E+N I+ +N E+++++ ++ +E+ ++ +E M+++ ++ N D L KE +
Sbjct: 594 KSQESNVSIQKENLELKEHIRQNEEELSRIRNEL--MQSLNQDSNSNFKDTLLKEREAEV 651
Query: 283 LQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLK-NA 341
+++ L+ NE + VA + K+E KL+L+ +D + H L E L N
Sbjct: 652 RNLKQNLSELEQLNE--NLKKVAFDVKMENEKLVLACED--------VRHQLEECLAGNN 701
Query: 342 QLDADKSNVM-ALQQGIQERDSQI----KMLTEQVEQYTKEMEKNTCIIEDLKNELQRNK 396
QL +K+ ++ L+ E ++++ K L E+ +Y K IE+L N N
Sbjct: 702 QLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEK-------TIEELSNARNLNT 754
Query: 397 GASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVY 456
A L + +K+ D+ + E ++ E + D +E L +L+ K +
Sbjct: 755 SALQLEHEHLIKLNQKKDM---EIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLIN 811
Query: 457 GLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMID 516
E + ++K ++++ E++ K S L +NE LR+ + + +++
Sbjct: 812 KKEIFIEKLKERSSKLQ---EELD-----------KYSQALRKNEILRQTIEEKDRSLGS 857
Query: 517 LTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLK--KKIRQMAQERGKRSATSGLTT 574
+ E N HL+++ R L+E +S D K + ++A E S L T
Sbjct: 858 MKEENN--HLQEELER------LREEQSRTAPVADPKTLDSVTELASE------VSQLNT 903
Query: 575 EDLNLTENISQGDRI----SERKLDLL-----SLKNMSEAQSKNEFL----SRELIEKER 621
+L E I +I ++ K+ LL K M E + ++E + ++ +EK+
Sbjct: 904 IKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDE 963
Query: 622 DLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLER 681
+++ + I + + +L EE + ++ +I Q K + + + L ER
Sbjct: 964 EIKSLQKTIEQIKTQLH---EERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETER 1020
Query: 682 LVNAIESKNAE--GIFDASLHLKAQVDQLTG----------RNEELRQELRESRKEAINY 729
LV I+ + E + + ++ L Q+DQL+ + ++L + +R + ++
Sbjct: 1021 LVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSH 1080
Query: 730 SQQLAKANLKID----HLEKETSLLRQS--EGSNVVFKGIDLPDGIAPSSASIINSQNEY 783
+Q + ++ EK ++L + E S++ + + D +A A++I Q+E
Sbjct: 1081 TQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDEN 1140
Query: 784 LIHLLQELENK-----EKKLKNLEDSLEDYNRKF-AVIRHQQSLLYKEYLSE--KETWKT 835
L E+ + ++NL + + + + A+ + Q+LL S E
Sbjct: 1141 K-KLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGV 1199
Query: 836 ESKTIKE---EKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVN 892
S +E E+ KL+ QV++ ++ + +Q +S ++++ L + ++ V N
Sbjct: 1200 NSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDN 1259
Query: 893 EKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKV 952
L YT L+ Q ++NE + A+V IG L K++ + K+ +
Sbjct: 1260 NSKLQVDYTGLI----QSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQ 1315
Query: 953 VDNSVSLS--ELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESI 1010
+ ++ L+ E +E+ ++ ++LQ++ L + +L+ + +L+E +
Sbjct: 1316 LSSASLLTPQSAECLRASKSEVLSESSELLQQE--LEELRKSLQEKDATIRTLQENNHRL 1373
Query: 1011 NKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNER 1070
+ + T E + + E K E D +K + D++ +K +L E
Sbjct: 1374 SDSIAATSELERKEHEQTDSEIKQLKE-KQDVLQKLLKEKDLLIKAKSDQLLSSNENFTN 1432
Query: 1071 QRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAV 1130
+ E+ E LR ++ ++ER LE ++ K+ + +K+ + R + ++ +A+
Sbjct: 1433 KVNEN-----ELLRQAVTNLKERILILE---MDIGKLKGENEKIVETYRGK--ETEYQAL 1482
Query: 1131 SDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDY 1190
+ + + + L + E E + + A ++L ++Q + E+ QLL+
Sbjct: 1483 QETNMKFSMMLREKEFE-------CHSMKEKALAFEQLLKEKEQGKTGELN----QLLNA 1531
Query: 1191 QAQSDEKSLIAKLHQHNVSLQLS----EATAL-GKLESITSKLQKMEAYNLRLEQKLDEK 1245
EK+++ + + V L L E TAL +++ + K + RL L E
Sbjct: 1532 VKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLES 1591
Query: 1246 EQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMK 1305
E + L +R LR+ + L +EK + ++N + +++
Sbjct: 1592 EDSYTREALAAEDREAKLRKKVTVL------------EEKLVSSSNAMENASHQASVQVE 1639
Query: 1306 NSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKL-NRE 1364
+ Q++ + + E L+L +E + + A + N M +E + +E + + E
Sbjct: 1640 SLQEQLNVVSKQRDETALQLSVSQEQVK-----QYALSLANLQMVLEHFQQEEKAMYSAE 1694
Query: 1365 LVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQ 1424
L K K+ +I+E+++ +LE +++ + +E A D L QLD+ + Q
Sbjct: 1695 LEKQKQ-------LIAEWKKNAENLEGKVISLQECLDEANAALDSAS-RLTEQLDVKEEQ 1746
Query: 1425 QNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKI 1460
E+ + +E + + L N E + K+
Sbjct: 1747 IEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
Score = 177 bits (449), Expect = 1e-43
Identities = 353/1739 (20%), Positives = 723/1739 (41%), Gaps = 279/1739 (16%)
Query: 790 ELENKEKKLK-NLEDSLEDYNRKFAVIR--HQQSLL-----YKEYLSEKETWKTESKTIK 841
+L+N K+LK N ++D+ + +V++ HQQ L ++E LS+ E E + +
Sbjct: 213 KLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLL 272
Query: 842 EEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQV------NEKS 895
++ ++ D K+ E + LQ++ E K + + KI + N++
Sbjct: 273 QQGGS--GVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRD 330
Query: 896 LIRQYTTLVELE-RQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVD 954
++R+ + +E RQ+ +E E K E ++ ++ + KE + + A++++V
Sbjct: 331 ILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTE-KERILAQSASVEEVFR 389
Query: 955 NSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKEL 1014
+LS+ E NE+ L +DN L + +N+ LK ++E + KE
Sbjct: 390 LQQALSDAE------NEIMRL--SSLNQDNSLAE----------DNLKLKMRIEVLEKEK 431
Query: 1015 EITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAE 1074
+ ++ ++ + KL NE + K+ T + +S+ ++ L + + Q
Sbjct: 432 SLLSQEKEELQMSL---LKLNNEYEVIKS----TATRDISLDSELHDLRLNLEAKEQELN 484
Query: 1075 HCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDAD 1134
E L +++++ +N E TK L K L Q+ E D + + + ++D +
Sbjct: 485 QSISEKETLIAEIEELDRQNQEA-TKHMILIKDQLSKQQNEG---DSIISKLKQDLND-E 539
Query: 1135 RQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQS 1194
++R+ +LE ++M++ E+ +E + + L+ +Q + +VE+L QL
Sbjct: 540 KKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL------- 592
Query: 1195 DEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARL 1254
K + NVS+Q L E I +++ L Q L++ + + L
Sbjct: 593 ------NKSQESNVSIQKEN---LELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTL 643
Query: 1255 EGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNM 1314
A+ +++L++ S L + K ++++N+KL + E Q E
Sbjct: 644 LKEREAE-----VRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLA 698
Query: 1315 ENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKY 1374
N L +E ++ TLK KG + EL + +L E K ++ I+
Sbjct: 699 GNNQLSLEKNT-----IVETLKMEKGEIEA--------ELCWAKKRLLEEANKYEKTIEE 745
Query: 1375 LNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQK 1434
L+N + + E ++ K ++++ M + + ++E Q+D ++ ++L+++ +
Sbjct: 746 LSNARNLNTSALQLEHEHLI---KLNQKKDMEIAELKKNIE-QMDTDHKETKDVLSSSLE 801
Query: 1435 FEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAE-- 1492
++ L N+ EI + K+KE L+E+L + ALR E
Sbjct: 802 EQKQLTQ-------LINKKEIFIEKLKER----------SSKLQEELDKYSQALRKNEIL 844
Query: 1493 -QNILSRDKVINELRLRLPATAER-EKLIAELGRKE--MEPKSHHTLKIAHQTIANMQAR 1548
Q I +D+ + ++ E E+L E R +PK+ ++ ++ +
Sbjct: 845 RQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTI 904
Query: 1549 LNQKEEVLKKYQRLLEKAREEQREIVKK-------------HEEDLHILHHRLELQADSS 1595
EE +K +Q+++E + + ++++ E ++ H +L L+ D
Sbjct: 905 KEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEE 964
Query: 1596 LNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDL---E 1652
+ ++T ++Q T + + I + + + Q+ + SL ++ DL E
Sbjct: 965 IKSLQKT----IEQIKTQLHEERQDI---QTDNSDIFQETKVQSLNIENGSEKHDLSKAE 1017
Query: 1653 RQREITELKVKEFENIKLQLQENHEDEVKKV----KAEVEDLKYLLDQSQKESQCLKSE- 1707
+R + +K +E E IKL L E + K++ K EV L ++ Q E Q L +
Sbjct: 1018 TERLVKGIKERELE-IKL-LNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARI 1075
Query: 1708 -----------LQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMT 1756
LQ Q +A + L E+ + LK + K + + A +
Sbjct: 1076 SSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
Query: 1757 AAAEERIISA---TSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNREN 1813
E + +S +S ++ Q + R RE +++ L++ L L+TS
Sbjct: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNE 1195
Query: 1814 SLTDNLNDLNNELQKKQKAYNKILREKE----------EIDQENDELKRQIKRLTSGL-- 1861
+ N N LQ++ K ++ + +E + E+ +L+ ++ +L + +
Sbjct: 1196 AGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLV 1255
Query: 1862 ---QGKPLTDNKQSLIEELQRKVKKLEN--------------------QLEGKVEEVD-- 1896
L + LI+ ++ KL+N L GK++ +
Sbjct: 1256 DSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQ 1315
Query: 1897 ------LKPMKEK--NAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKD 1948
L P + A + + E + Q ++E +R L+EK+ + TL + + L D
Sbjct: 1316 LSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSD 1375
Query: 1949 LFAKADKEKLTLQRKL-KTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQ 2007
A + L+RK + T + Q+ KE +++ ++ L ++ ++ ++ Q
Sbjct: 1376 SIAATSE----LERKEHEQTDSEIKQL---------KEKQDVLQKLLKEKDLLIKAKSDQ 1422
Query: 2008 ALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLK 2067
L + + +N L++ + L+++ + I ++ ++ E KE
Sbjct: 1423 LLSSNENFTNKVNENELLRQAVTNLKERI---LILEMDIGKLKGENEKIVETYRGKETEY 1479
Query: 2068 LSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTI 2127
+ + +KF + +R+ + C +K EKA +L + G++G
Sbjct: 1480 QALQETNMKFSM------------MLREKEFECHSMK-EKALAFEQLLKEKEQGKTG--- 1523
Query: 2128 PELEKTIGLMKKVVEKV---QRENEQLKKASGILTSEKMANIEQENE---------KLKA 2175
EL + + +K + EK Q+E +Q+ A L ++M N +NE +
Sbjct: 1524 -ELNQLLNAVKSMQEKTVVFQQERDQVMLA---LKQKQMENTALQNEVQRLRDKEFRSNQ 1579
Query: 2176 ELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNE 2235
ELE+L+ HL ES+ T + +A +R K KK T EKL + N +E +
Sbjct: 1580 ELERLRNHL-------LESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASH 1632
Query: 2236 KMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITD 2295
+ +VQ+E ++L + + S S + + + Y L L
Sbjct: 1633 QASVQVESLQEQLNVVSKQRDETALQLSVSQEQV---KQYALSLANL------------- 1676
Query: 2296 LKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQ-VLRLANHQLDKE 2354
Q+V E ++E+K Y+ +LE+Q +++ + AE +G LQ L AN LD
Sbjct: 1677 --QMVLEHFQQEEKA-MYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALD-S 1732
Query: 2355 KAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKEL 2413
+ L Q++ ++Q + ++L++++ D + Q K+ L + K L + L
Sbjct: 1733 ASRLTEQLDVKEEQI---EELKRQNELRQEMLD-DVQKKLMSLANSSEGKVDKVLMRNL 1787
Score = 160 bits (405), Expect = 1e-38
Identities = 334/1675 (19%), Positives = 700/1675 (41%), Gaps = 213/1675 (12%)
Query: 9 EIMKVDPDDLPRQEELADNLLISLSK-----VEVNELKSEKQENVIHLFRITQSLMKMKA 63
EI + ++L EE + L L + +E + K + + I + +I + K
Sbjct: 249 EISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKM 308
Query: 64 QEVELALEEVEKA-------------GEEQAKFEN-QLKTKVMKLENELEMAQQSAGGR- 108
+++E ++++ K +EQ E Q+ + L+ E Q SA +
Sbjct: 309 EQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQS 368
Query: 109 DTRFLRNEICQLEKQLEQKDR---ELEDMEKELEKEKKVNEQ--LALRNEEAENENSKLR 163
DT + I +E+ R L D E E+ + +N+ LA N + + L
Sbjct: 369 DTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLE 428
Query: 164 RENKRLKKKNEQLCQDIIDYQKQIDSQKETL---LSRRGEDSDYRSQLSKKNYELIQYLD 220
+E L ++ E+L ++ + + K T +S E D R L K EL Q +
Sbjct: 429 KEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSIS 488
Query: 221 EIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDH 280
E +TL E+++ QNQE K++ ++ K +E D++I +LK++ +
Sbjct: 489 EKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNE----------GDSIISKLKQDLND 538
Query: 281 YQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKD-DEIIEYQQMLHNLREKLK 339
+ +V +L EDD + + V++ KLI S +++ +Q L + E L
Sbjct: 539 EKKRVHQL---------EDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLV 589
Query: 340 NAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGAS 399
+ + +SNV IQ+ + ++K E + Q +E+ + ++NEL ++
Sbjct: 590 DQLNKSQESNV-----SIQKENLELK---EHIRQNEEELSR-------IRNELMQS---- 630
Query: 400 TLSQQTHMKIQSTLDILKEKTKEAERTAE-LAEADAREKDKELVEALKRLKDYESGVYGL 458
L+Q ++ + TL LKE+ E + L+E + ++ + V ++++ E V
Sbjct: 631 -LNQDSNSNFKDTL--LKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMEN-EKLVLAC 686
Query: 459 EDAVVEIKNC---KNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMI 515
ED +++ C NQ+ + I + T ++ K E++ ++ + L E KT+
Sbjct: 687 EDVRHQLEECLAGNNQLSLEKNTI-VETLKMEKGEIE-AELCWAKKRLLEEANKYEKTIE 744
Query: 516 DLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQM-AQERGKRSATSGLTT 574
+L+ N+++L + E++ L+K + + E +LKK I QM + + S
Sbjct: 745 ELS---NARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLE 801
Query: 575 EDLNLTENISQGD----RISERKLDLLS-LKNMSEAQSKNEFLSRELIEKERDLERSRTV 629
E LT+ I++ + ++ ER L L S+A KNE L + + EK+R L +
Sbjct: 802 EQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMK-- 859
Query: 630 IAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESK 689
EEN L+E ++ + + E + V +T + S+ L + +
Sbjct: 860 ------------EENNHLQEELERLRE---EQSRTAPVADPKT---LDSVTELASEVSQL 901
Query: 690 NA--EGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANL--------- 738
N E + + H + ++ +L Q L+E +KE + Q + N
Sbjct: 902 NTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEK 961
Query: 739 --KIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKE- 795
+I L+K ++ D D + +N +N H L + E +
Sbjct: 962 DEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERL 1021
Query: 796 -KKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQD 854
K +K E ++ N K + Q L K+ + K T + K ++ +
Sbjct: 1022 VKGIKERELEIKLLNEKNISLTKQIDQLSKDEVG-KLTQIIQQKDLEIQALHARISSTSH 1080
Query: 855 AIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI----RQYTTLVELERQL 910
V L A M+ +++ +L E +R+ + L+ ++ + L++L+ +
Sbjct: 1081 TQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDEN 1140
Query: 911 RKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYN 970
+K + + ++ M E + + + R K++ I ++ QK L N+
Sbjct: 1141 KKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALS--QKCQTLLAVLQTSSTGNEAGG 1198
Query: 971 ELTAKYRDILQKDNMLVQRTSNLE-----------HLECENISLKEQVESINKELEITKE 1019
+ ++ ++LQ+ + L Q+ +E +++ E+ L+E++ + ++ + +
Sbjct: 1199 VNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSD 1258
Query: 1020 KLHTIE-------QAWEQ-ETKLGN-ESSMDKAKKSITNS-----------DIVSISKKI 1059
++ Q++EQ ETKL N + + + SI DI+S
Sbjct: 1259 NNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSS 1318
Query: 1060 TMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLR 1119
L + E RA + + E +++EE L+ K A + + Q
Sbjct: 1319 ASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTL--------QENN 1370
Query: 1120 DELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKE 1179
L+DS++ A S+ +R+ E E+ + E+K +L+E D+ ++ ++ + +++ +
Sbjct: 1371 HRLSDSIA-ATSELERK---EHEQTDSEIK----QLKEKQDVLQKLLKEKDLLIKAKSDQ 1422
Query: 1180 VESLRMQLLDYQAQSDE-KSLIAKLHQHNVSLQLSEATALGKLESIT-------SKLQKM 1231
+ S + +++ + + L + + L++ G+ E I ++ Q +
Sbjct: 1423 LLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQAL 1482
Query: 1232 EAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMI 1291
+ N++ L EKE + + + + L++ Q + + L + + +
Sbjct: 1483 QETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVF 1542
Query: 1292 QLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKL----KGLEELISTLKDTKGA--QKVI 1345
Q + D+ +M +K Q E+ ++N+ + K + LE L + L +++ + ++ +
Sbjct: 1543 QQERDQ--VMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREAL 1600
Query: 1346 NWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEER-- 1403
+ +LR + L +LV ++ N + + SL+E++ +K +E
Sbjct: 1601 AAEDREAKLRKKVTVLEEKLVSSSNAME---NASHQASVQVESLQEQLNVVSKQRDETAL 1657
Query: 1404 QMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKEN 1463
Q++ Q +V + L + + Q + F++ ++ L QL +K EN
Sbjct: 1658 QLSVSQEQVK-QYALSLANLQM-----VLEHFQQEEKAMYSAELEKQKQLIAEWKKNAEN 1711
Query: 1464 IRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELG 1523
+ + + C L+E +SA RL EQ + +++ I EL+ + R++++ ++
Sbjct: 1712 LEGKVISLQEC--LDEANAALDSASRLTEQ-LDVKEEQIEELKRQ---NELRQEMLDDVQ 1765
Query: 1524 RKEMEPKSHHTLKIAHQTIANM-----QARLNQKEEVLKKYQRLLEKAREEQREI 1573
+K M + K+ + N+ NQ+ EVL+ +L REE ++
Sbjct: 1766 KKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQL 1820
Score = 141 bits (356), Expect = 7e-33
Identities = 292/1450 (20%), Positives = 596/1450 (41%), Gaps = 194/1450 (13%)
Query: 1121 ELADSVSKAVSDADRQRILELEKNEME-LKVEVSKLREISDIARRQVEILNAQQQSRDKE 1179
EL DS +K + IL E ++ L ++ + E S+I +Q + + + Q + KE
Sbjct: 48 ELPDSRTKEIEAI--HAILRSENERLKKLCTDLEEKHEASEIQIKQ-QSTSYRNQLQQKE 104
Query: 1180 VE---------SLRMQLLDYQAQSDE------------KSLIAKLHQHNVSLQLSEATAL 1218
VE +L+ QLL Q+ + S A H+ S +
Sbjct: 105 VEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDF 164
Query: 1219 GKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKH-----LRQTIQSLRRQ 1273
G + S ++ ++ RLE ++ ++ +G + + L+ I+ L++
Sbjct: 165 GDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQN 224
Query: 1274 FSGALPLAQQEKFSKTMIQLQN-DKLKIMQEMKNSQQEHRNMENKTLEME-LKLKGLEEL 1331
S + Q E M LQN + K+ + + ++E + E + E+E L +G +
Sbjct: 225 RSQEIDDHQHE-----MSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGV 279
Query: 1332 ISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEE 1391
I T K+ I+ L++++++ +++ + +++IK +N +S E L
Sbjct: 280 IET-----DLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334
Query: 1392 EIVQQNKFHEERQMAWDQREVDLE-RQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLP 1450
E Q N E+RQ+ + + LE +L +Q++ + ++ + S+ +
Sbjct: 335 EQEQLNV--EKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVF---- 388
Query: 1451 NQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLA-EQNILSRDKVINELRLRL 1509
+L+ AL + I + E+ LK K L E+++LS++K EL++ L
Sbjct: 389 -RLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEK--EELQMSL 445
Query: 1510 PATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKARE- 1568
++I +++ S H N++A+ + + + + + L+ + E
Sbjct: 446 LKLNNEYEVIKSTATRDISLDSE-----LHDLRLNLEAKEQELNQSISEKETLIAEIEEL 500
Query: 1569 -EQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEME 1627
Q + KH + + + + DS ++K KQ D K +L + +
Sbjct: 501 DRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLND----------EKKRVHQLEDDK 550
Query: 1628 QTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEV 1687
+ ++ D L++ + DL ++ E KV EN+ QL ++ E V K +
Sbjct: 551 MDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKV---ENLVDQLNKSQESNVSIQKENL 607
Query: 1688 EDLKYLLDQSQKESQCLKSELQAQ--KEANSRAPTTTMRNL---VERLKSQLALKEKQQK 1742
E LK + Q+++E +++EL +++NS T ++ V LK L+ E+ +
Sbjct: 608 E-LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNE 666
Query: 1743 ALSRALLELRAEMTAAAEERIISATSQKEAHL------NVQQIVDRHT--RELKTQVEDL 1794
L + +++ E E+++ A L N Q ++++T LK + ++
Sbjct: 667 NLKKVAFDVKME-----NEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
Query: 1795 NENLLKLKEALKTSKNRENSLTDNLNDLNN-ELQKKQKAYNKILREKEEIDQENDELKRQ 1853
L K+ L N+ + L++ N Q + +++ ++ D E ELK+
Sbjct: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKN 781
Query: 1854 IKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAK--EELIR 1911
I+++ + K D S +EE Q+++ +L N+ +E+ ++ +KE+++K EEL +
Sbjct: 782 IEQMDT--DHKETKDVLSSSLEE-QKQLTQLINK-----KEIFIEKLKERSSKLQEELDK 833
Query: 1912 WEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTV 1971
+ + + K E +R ++EK+ + ++ ++ N L++ E L+ + T
Sbjct: 834 YSQALR---KNEILRQTIEEKDRSLGSMKEENNHLQE-------ELERLREEQSRTAPVA 883
Query: 1972 DQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHA 2031
D E E+ +L LE +I + HQ ++ED + L + L
Sbjct: 884 DPKTLDSVTELASEVSQLNTIKEHLEEEIKH---HQ-----KIIEDQNQSKMQLLQSLQE 935
Query: 2032 LEKQFSKDTYSKPSISGIESDDHCQREQE---LQKENLKLSSENIELKFQLEQANKDL-P 2087
+K+ + Y ++ + ++++E LQK ++ ++ E + ++ N D+
Sbjct: 936 QKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQ 995
Query: 2088 RLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRE 2147
K Q +++ E KAE +R + K I E E I L+ + +
Sbjct: 996 ETKVQSLNIENGSEKHDLSKAETERLV----------KGIKERELEIKLLNE-------K 1038
Query: 2148 NEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQ--------LSMHYESKTKGT 2199
N L K L+ +++ + Q ++ E++ L A + L ++
Sbjct: 1039 NISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMER 1098
Query: 2200 EKIIA-------ENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAE 2252
EK+ A EN L+ E K D A L+ N+K++ + E +G+ + F E
Sbjct: 1099 EKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDM-FRE 1157
Query: 2253 S--------RGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEAT 2304
+ R +E D+ S K + + +T E NQ ++L++E
Sbjct: 1158 TIQNLSRIIREKDIE-IDALSQKCQTLLAVLQTSSTGNEAGGVNSNQ----FEELLQERD 1212
Query: 2305 EREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLA----NHQLDKEKAELIH 2360
+ +Q+V K E +Q + ++++ + Q +LQ L N +L + LI
Sbjct: 1213 KLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQ 1272
Query: 2361 QIEANKD------------QSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
E N+ Q D L K+ + QL + L E ++
Sbjct: 1273 SYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRA 1332
Query: 2409 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFED 2468
K E+ E +L EE++K++ ++ + ++ L+ +AA+ E E
Sbjct: 1333 SKSEV-------LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELER 1385
Query: 2469 EEESPVNFPI 2478
+E + I
Sbjct: 1386 KEHEQTDSEI 1395
Score = 108 bits (271), Expect = 5e-23
Identities = 201/969 (20%), Positives = 401/969 (41%), Gaps = 235/969 (24%)
Query: 1624 AEMEQTVAEQDDSLSSLL----VKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDE 1679
AE+ + ++ +++ ++L +LKK+ DLE + E +E+++K+ + E E
Sbjct: 47 AELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVE 106
Query: 1680 VKKVKAEVEDLKYLLDQSQKESQCLKS---------------------------ELQAQK 1712
+ +KA L+ L + Q +Q + S ++
Sbjct: 107 ISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGD 166
Query: 1713 EANSRAPTTTMRNLVERLKSQ------LALKEKQQKA----------LSRALLELRAEMT 1756
+S+ + N V RL+S+ +A K Q L + EL+ +
Sbjct: 167 IISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRS 226
Query: 1757 AAAEERIISATSQKEAH-LNVQQIVDRHTREL---KTQVEDLNENLL------------- 1799
++ + + AH + +I RH EL + ++E+L ENLL
Sbjct: 227 QEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEEL-ENLLQQGGSGVIETDLS 285
Query: 1800 KLKEALKT----------SKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDE 1849
K+ E KT S + L D + D+N +L + + + RE+E+++ E +
Sbjct: 286 KIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQ 345
Query: 1850 LKRQIKRL---------TSGLQGKPLTDNKQSL-----IEE---LQRKVKKLENQL---- 1888
+ + + L ++ Q +T+ ++ L +EE LQ+ + EN++
Sbjct: 346 IMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLS 405
Query: 1889 ----EGKVEE--VDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNK---LKEKEGEVFTL 1939
+ + E + LK E KE+ + +E ++ Q + + N+ +K +L
Sbjct: 406 SLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISL 465
Query: 1940 TKQLNTLK-DLFAK---------------ADKEKLTLQRKLKTTGM-TVDQVLGIRALES 1982
+L+ L+ +L AK A+ E+L Q + T M + L + E
Sbjct: 466 DSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEG 525
Query: 1983 E-------KELEELKKRNLDLENDILYMRAHQALPRDSVVE------DLHLQNRYLQEKL 2029
+ ++L + KKR LE+D + + + ++ +++ DLHL + L++K+
Sbjct: 526 DSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKV 585
Query: 2030 HALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRL 2089
L Q +K Q+ N+ + EN+ELK + Q ++L R+
Sbjct: 586 ENLVDQLNKS----------------------QESNVSIQKENLELKEHIRQNEEELSRI 623
Query: 2090 KNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENE 2149
+N E+ + L S + E E + +K+ + ++++ NE
Sbjct: 624 RN-----------------ELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNE 666
Query: 2150 QLKKASGILTSEKMANIEQENEKLKAELEKLKAHL------GHQLSMHYES--KTKGTEK 2201
LKK + +++ ENEKL E ++ L +QLS+ + +T EK
Sbjct: 667 NLKKVA--------FDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEK 718
Query: 2202 --IIAE----NERLRKELKKETDAAEKLRIAKN-----------NLEILNEKMTVQLEET 2244
I AE +RL +E K E+L A+N +L LN+K +++ E
Sbjct: 719 GEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAEL 778
Query: 2245 GKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEAT 2304
K ++ ++ D K K ++ + + E K+L I KK I LK+ ++
Sbjct: 779 KKNIEQMDT--------DHKETKDVLSSSLEEQ--KQLTQLINKKEIFIEKLKE---RSS 825
Query: 2305 EREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEA 2364
+ +++++KY++ L + +IL+ E + G +E E L ++E
Sbjct: 826 KLQEELDKYSQALRKN-EILRQTIEEKDRSLGSMKE-------------ENNHLQEELER 871
Query: 2365 NKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEI 2424
+++ + + D L + + +L +++ + K+HL+EEIK +K +E+ + S + +
Sbjct: 872 LREEQSRTAPVADPKTL-DSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLL 930
Query: 2425 EDLKYNYKE 2433
+ L+ KE
Sbjct: 931 QSLQEQKKE 939
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 182 bits (462), Expect = 4e-45
Identities = 358/1682 (21%), Positives = 734/1682 (43%), Gaps = 273/1682 (16%)
Query: 77 GEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEK 136
G ++K E K ++K + M Q A R T +LEK++E+ R E
Sbjct: 16 GTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCT--------ELEKEIEEL-RSKPVTEG 66
Query: 137 ELEKEKKVNEQL-ALRNEEAENENS--KLRRENKRLKKKNE-----------QLCQDIID 182
+ K + E+L AL E+AE E L++EN ++K++ E +L Q I+
Sbjct: 67 TGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHIN 126
Query: 183 YQKQIDSQKETLLSRRGEDSDYRSQLSKK-------NYELIQYLDEIQTLTEAN-EKIEV 234
Y K+I++ K L++ R + S+ ++ L K+ EL + L + Q +E N +K++
Sbjct: 127 YVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQL-KFQNNSEDNVKKLQE 185
Query: 235 QNQEMRKNLEESVQEMEKMTD-EYNRMKAIVHQTDNVIDQLKKENDHYQLQV----QELT 289
+ +++R EE + ++K D + K V Q N+I+ + HYQ + +EL
Sbjct: 186 EIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIE---ANSQHYQKNINSLQEELL 242
Query: 290 DLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIE----------------YQQMLHN 333
L EE +M + A +E + + +K +E+ E Y+ L N
Sbjct: 243 QLKAIHQEEVKELMCQIEASAKEHEAEI-NKLNELKENLVKQCEASEKNIQKKYECELEN 301
Query: 334 LREKLKNAQLDAD----------------KSNVMALQQGIQERDSQIKMLTEQV------ 371
LR+ NA D V L+ ++E +SQ +L ++V
Sbjct: 302 LRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNL 361
Query: 372 -------EQYTKE-------------------MEKNTCIIEDLKNELQ-RNKGASTLSQQ 404
Q+ K+ E+ C+IE LK+EL NK +Q
Sbjct: 362 KLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQ 421
Query: 405 THMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVE 464
+ ++QS K + + +EL E + +KE + + ++ + L+ E
Sbjct: 422 HNREVQSL------KEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQE 475
Query: 465 -IKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVG-----LEPKTMIDLT 518
I N ++ +I +EIL E+ + KIS E E+++++ L+ K T
Sbjct: 476 AILNYESLREI----MEILQTELGESAGKIS---QEFESMKQQQASDVHELQQKLRTAFT 528
Query: 519 EFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLN 578
E +++ + + EN+ LL + E + E L+ I+ + ++ G + L+ D
Sbjct: 529 E-KDALLETVNRLQGENEKLLSQQELVPE----LENTIKNLQEKNGVYLLS--LSQRDTM 581
Query: 579 LTENISQGDRISERKLDLLS-LKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKL 637
L E + + ++E K D ++ LKN E E+ + ER +I + K+
Sbjct: 582 LKELEGKINSLTEEKDDFINKLKNSHE----------EMDNFHKKCEREERLILELGKKV 631
Query: 638 KELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAE--GIF 695
++ ++ N +LE+ + E+ ++E K+ D + ++ ++ L E +AE ++
Sbjct: 632 EQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLY 691
Query: 696 DASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEG 755
+ + L ++ QL+ R+ E+ +E + +Q K L ++ + LL +
Sbjct: 692 EENNKLSSEKKQLS-RDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQV 750
Query: 756 SNVVFK----------GIDL-PDGIAPSSASIINSQNEYLIHLLQELEN----KEKKLKN 800
+ K G ++ D +++ + E L + +E N +++K+
Sbjct: 751 QKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLE 810
Query: 801 LEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQV--------- 851
LE ++ + V + L ++Y EK + E + I+ EK L+ +
Sbjct: 811 LEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEK 870
Query: 852 -----QQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVEL 906
Q I+V+E + + ++ +++ K + E+ +L+ +K L + L+ L
Sbjct: 871 TRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLE--QKELRDRRAELILL 928
Query: 907 ERQLRKENEKQKNELLSMEAEVCEKIGCLQ---RFKEMAIFKIAAL----QKVVDNS--- 956
+ L K + KN+ LS E+ EKI L+ + KE I KI + +K +D+S
Sbjct: 929 KDSLAK-SPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
Query: 957 --VSLSELELANKQYNELTAKYRDILQ----KDNMLVQRTSNLEHLECEN---ISLKEQV 1007
ELE + ++L+A RD++Q N+L++ E L+ E + + ++
Sbjct: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Query: 1008 ESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKEL 1067
E + ++L + + TI + E L ++ K + I+ + + M++ KEL
Sbjct: 1048 EDLTRQLRNSTLQCETINS--DNEDLLARIETLQSNAK-LLEVQILEVQRAKAMVD-KEL 1103
Query: 1068 NERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVS 1127
E ++ + QK+ EH T++ ++EE +L+ + +L K Q++E + +D ++
Sbjct: 1104 -EAEKLQKEQKIKEH-ATTVNELEELQVQLQKEKKQLQK---TMQELELVKKDAQQTTLM 1158
Query: 1128 KAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQL 1187
+ AD +R+++ E+ K+ +K +I D+ ++++I +Q++ +E+ SL+ +
Sbjct: 1159 N-MEIADYERLMK----ELNQKL-TNKNNKIEDL-EQEIKIQKQKQETLQEEITSLQSSV 1211
Query: 1188 LDYQAQSDE-KSLIAKLHQHNVSLQLSEATALGKLESITSKL----QKMEAYNLRLEQKL 1242
Y+ ++ + K L+ K + + +E L S+ +L Q++E Y ++L +
Sbjct: 1212 QQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEIT 1271
Query: 1243 DEKEQALYYARLEGRNRAKHL---RQTIQSLRRQFSG-----ALPLAQQEKFS---KTMI 1291
EK + + + + L +Q + +L+ + A ++ E + ++
Sbjct: 1272 SEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVL 1331
Query: 1292 QLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLK----GLEELISTLKDTKGA-QKVIN 1346
+ Q +K E + ++QE ++E ++++KL+ L+ +S L+ + ++
Sbjct: 1332 KQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLE 1391
Query: 1347 WHMK-IEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSL-EEEIVQQNKFHEE-R 1403
H K ++E +E +L +L + E + SE+ +T+S L + V +N F ++ R
Sbjct: 1392 RHNKMLQETVSKEAELREKLCSIQSENMMMK---SEHTQTVSQLTSQNEVLRNSFRDQVR 1448
Query: 1404 QMAWDQREV--DLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIK 1461
+ + R+ L++QL + Q ++ N +P+ P + +L+ ++
Sbjct: 1449 HLQEEHRKTVETLQQQLSKMEAQLFQLKN-------------EPTTRSPVSSQQSLKNLR 1495
Query: 1462 ENIRIILE-------TRATCKSLEEKLKEKESALRLAEQNILSRDKVIN--ELRLRLP-- 1510
E L TR + +E E S+ Q++ ++++N E +L P
Sbjct: 1496 ERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSL---EQLLNSPETKLEPPLW 1552
Query: 1511 -ATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREE 1569
A +E+L+ +L + H + +T A A L ++ ++LK R LE+ +E
Sbjct: 1553 HAEFTKEELVQKL--SSTTKSADHLNGLLRETEAT-NAILMEQIKLLKSEIRRLERNQER 1609
Query: 1570 QR 1571
++
Sbjct: 1610 EK 1611
Score = 179 bits (453), Expect = 4e-44
Identities = 306/1457 (21%), Positives = 610/1457 (41%), Gaps = 205/1457 (14%)
Query: 34 KVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAG--------------EE 79
+ E+N+L +E +EN++ ++ ++ K E LE + KA +E
Sbjct: 267 EAEINKL-NELKENLVKQCEASEKNIQKK---YECELENLRKATSNANQDNQICSILLQE 322
Query: 80 QAKFENQLKTKVMKLENELEM--AQQSAGGRDTRFLRNEICQLEKQLEQ-KDRELEDMEK 136
E + KV LE+ L+ +Q S + ++ N +LE + KD + E
Sbjct: 323 NTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHERE- 381
Query: 137 ELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLS 196
+ E K+NE L L EE KL+ E L N+Q C + + +++ S KE
Sbjct: 382 --DLEFKINE-LLLAKEEQGCVIEKLKSE---LAGLNKQFCYTVEQHNREVQSLKEQHQK 435
Query: 197 RRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDE 256
E ++ + LS E + + EIQ L E E ++ + QE N E + ME + E
Sbjct: 436 EISELNE--TFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTE 493
Query: 257 YNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLI 316
+ Q + Q + + H EL L++ E D ++ VN
Sbjct: 494 LGESAGKISQEFESMKQQQASDVH------ELQQKLRTAFTEKDALLETVNR-------- 539
Query: 317 LSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTK 376
L ++++++ Q+++ L +KN Q +K+ V L + +RD+ +K L ++ T+
Sbjct: 540 LQGENEKLLSQQELVPELENTIKNLQ---EKNGVYLLS--LSQRDTMLKELEGKINSLTE 594
Query: 377 EMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADARE 436
E + I LKN + H K + ++ E K+ E+T + ++ +
Sbjct: 595 EKDD---FINKLKNSHEE-------MDNFHKKCEREERLILELGKKVEQTIQY-NSELEQ 643
Query: 437 KDKELVEALKR-LKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISD 495
K EL L+ LK+ + LE +V++K ++ E++ L +E NKL +
Sbjct: 644 KVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQ 703
Query: 496 FLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKK 555
+ E V L K + L E K Q E L K +E+ + ++L +K +
Sbjct: 704 LSRDLE-----VFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQ 758
Query: 556 IRQMAQERGKRSATSGLTTEDLNLTENISQG-DRISERKLDL--------LSL-KNMSEA 605
+ +E G + + +N+ + + + +I+E K +L L L K +
Sbjct: 759 LYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCL 818
Query: 606 QSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDP 665
Q ++ EL RD E+ + ++ K +L+E+ E + L+ + E+ A ++ + +
Sbjct: 819 QEESVVQCEELKSLLRDYEQEKVLLRK---ELEEIQSEKEALQSDLLEMKNANEKTRLEN 875
Query: 666 D---VKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRES 722
++ E S E I ++ + +LK ++Q +ELR+
Sbjct: 876 QNLLIQVEEVSQTCSKSE-----IHNEKEKCFIKEHENLKPLLEQ---------KELRDR 921
Query: 723 RKEAINYSQQLAKA-NLKIDHL-------EKETSLLRQSEGSNVVFKGIDLPDGIAPSSA 774
R E I LAK+ ++K D L EK +L ++ + I L +A +
Sbjct: 922 RAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKL---VAVKAK 978
Query: 775 SIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWK 834
++S + + +ELE+ + L S+ D +I+ +S YK L E E
Sbjct: 979 KELDSSRKETQTVKEELESLRSEKDQLSASMRD------LIQGAES--YKNLLLEYEKQS 1030
Query: 835 TESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEK 894
+ KE E +++ +++ N+ L ++SD + +LA +I LQ N K
Sbjct: 1031 EQLDVEKERANNFEHRIEDLTRQLR--NSTLQCETINSDN-EDLLA----RIETLQSNAK 1083
Query: 895 SLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVD 954
L Q + + + KE E +K L E ++ E + +E+ + LQK
Sbjct: 1084 LLEVQILEVQRAKAMVDKELEAEK---LQKEQKIKEHATTVNELEELQV----QLQKEKK 1136
Query: 955 N-SVSLSELELANKQYNELT------AKYRDILQKDNM-LVQRTSNLEHLECENISLKEQ 1006
++ ELEL K + T A Y ++++ N L + + +E LE E K++
Sbjct: 1137 QLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQK 1196
Query: 1007 VESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMK- 1065
E++ +E+ + +++Q E+ TK+ + + K KK + +S I +K
Sbjct: 1197 QETLQEEITSLQS---SVQQYEEKNTKI--KQLLVKTKKELADSKQAETDHLILQASLKG 1251
Query: 1066 ---------ELNERQRAE---HCQKMYEHLRTSLKQMEER---------NFELETKFAEL 1104
E+ + Q AE K++EHL+TS +Q + + E + A+
Sbjct: 1252 ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKA 1311
Query: 1105 TKINLDAQ------KVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREI 1158
+ + ++ +V +L+ + S+S+A ++ +Q LE +LK+++ +
Sbjct: 1312 EQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNN 1371
Query: 1159 SDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATAL 1218
I +++ L ++ + + + + + +A+ EK + + N+ ++ +
Sbjct: 1372 LQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREK--LCSIQSENMMMKSEHTQTV 1429
Query: 1219 GKLESITSKLQKMEAYNLR------------LEQKLDEKEQALYYARLEGRNRAK-HLRQ 1265
+L S L+ +R L+Q+L + E L+ + E R+ +Q
Sbjct: 1430 SQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQ 1489
Query: 1266 TIQSLRRQFSGALPLAQQEKFSKT-----------MIQLQNDKLKIMQEMKNSQQE---- 1310
++++LR + + LPL ++ + + + ++++ NS +
Sbjct: 1490 SLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEP 1549
Query: 1311 ---HRNMENKTLEMELK--LKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNREL 1365
H + L +L K + L L++T+ ++ +K+ + ++ L+ N+E
Sbjct: 1550 PLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQER 1609
Query: 1366 VKDKEEIKYLNNIISEY 1382
K ++YL N++ ++
Sbjct: 1610 EKSAANLEYLKNVLLQF 1626
Score = 160 bits (405), Expect = 1e-38
Identities = 345/1708 (20%), Positives = 722/1708 (42%), Gaps = 192/1708 (11%)
Query: 249 EMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNA 308
E+EK +E R K + T ++I L + D L+ E S +E+ + V
Sbjct: 50 ELEKEIEEL-RSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVED 108
Query: 309 KVEEWKLILSSKDDEIIEYQQMLHNLREKLK--NAQLDADKSNVMALQQGIQERDSQIKM 366
V + + I Y + + NL+ +L ++ DK+N LQ+ ++E +
Sbjct: 109 SVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKAN---LQKQLEEAMNTQLE 165
Query: 367 LTEQVEQYTKEMEKNTCIIEDLKNELQRNK-GASTLSQQTHMKIQSTLDILKEKTKEAER 425
L+EQ++ + E N ++ L+ E+++ + G ++ +T D KE + +
Sbjct: 166 LSEQLK-FQNNSEDN---VKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQN 221
Query: 426 TAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKE 485
E ++ L E L +LK E+K QI+ +E E E
Sbjct: 222 IIEANSQHYQKNINSLQEELLQLKAIHQE---------EVKELMCQIEASAKEHEA---E 269
Query: 486 INKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQI---LLKEI 542
INKL + + + EA + + + K +L R + Q +NQI LL+E
Sbjct: 270 INKLNELKENLVKQCEASEKNI--QKKYECELENLRKATSNANQ----DNQICSILLQEN 323
Query: 543 ESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNM 602
+E+ + +K++ + + + + +++ N+ + KL++ +
Sbjct: 324 TFVEQV---VNEKVKHLEDTLKELESQHSILKDEVTYMNNL-------KLKLEMDAQHIK 373
Query: 603 SEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQ 662
E + E L ++ E E VI K +++L L ++ E +Q++KE
Sbjct: 374 DEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQH 433
Query: 663 KDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRES 722
+ + ET L E+L E + LK Q + L +E
Sbjct: 434 QKEISELNETFLSDSEKEKLTLMFEIQG----------LKEQCENLQQEKQEAILNYESL 483
Query: 723 RKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASI-----I 777
R+ +L ++ KI +E ++Q + S+V L A + +
Sbjct: 484 REIMEILQTELGESAGKIS---QEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRL 540
Query: 778 NSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTES 837
+NE L+ + + E +KNL++ ++ +Y LS+++T
Sbjct: 541 QGENEKLLSQQELVPELENTIKNLQE---------------KNGVYLLSLSQRDTM---- 581
Query: 838 KTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
+KE + K+ + E ++ +N L+ +EM + R E+ LI
Sbjct: 582 --LKELEGKINSLTE-------EKDDFINKLKNSHEEMDNFHKKCER--------EERLI 624
Query: 898 RQYTTLVELERQLRKENEKQKNELLS-MEAEVCEKIGCLQRFKEMAI-FKIAALQKVVDN 955
+ VE Q E E++ NEL +E + EK Q+ +++ + K+ + K V +
Sbjct: 625 LELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLS 684
Query: 956 SVSLSELELANKQYNELTAKYRDI----LQKDNMLVQRTSNLEHLECENISLKEQVESIN 1011
+ S E NK +E RD+ QK++++++ ++ LE + + E+ +++N
Sbjct: 685 AEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKE--HITQLEKKLQLMVEEQDNLN 742
Query: 1012 KELEITK-EKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNER 1070
K LE + +KL Q + ++G+E S D +K + N + ++ + + + ++ N
Sbjct: 743 KLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNV-LQAVGESLAKINEEKCNLA 801
Query: 1071 QRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAV 1130
+ + +K+ E L +K ++E E + EL + D ++ + +LR EL + S+
Sbjct: 802 FQRD--EKVLE-LEKEIKCLQE---ESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE-- 853
Query: 1131 SDADRQRILEL----EKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQ 1186
+A + +LE+ EK +E + + ++ E+S + EI N +++ KE E+L+
Sbjct: 854 KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKS-EIHNEKEKCFIKEHENLK-P 911
Query: 1187 LLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKE 1246
LL+ + D ++ + L + L ++ + K++ +E E+K+++ +
Sbjct: 912 LLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIK 971
Query: 1247 QALYYARLE---GRNRAKHLRQTIQSLRR---QFSGAL-PLAQQEKFSKTMI---QLQND 1296
A+ E R + +++ ++SLR Q S ++ L Q + K ++ + Q++
Sbjct: 972 LVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSE 1031
Query: 1297 KLKIMQEMKNSQQEH-----RNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKI 1351
+L + +E N+ + R + N TL+ E E+L++ ++ + K++ ++I
Sbjct: 1032 QLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLE--VQI 1089
Query: 1352 EELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQRE 1411
E++ + +++EL +K + + I E+ T++ LEE VQ K E++Q+ +E
Sbjct: 1090 LEVQRAKAMVDKELEAEKLQKEQK---IKEHATTVNELEELQVQLQK--EKKQLQKTMQE 1144
Query: 1412 VDLERQLDIFDRQQNEILNAA-QKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILET 1470
++L ++ D QQ ++N +E + N++E ++IK
Sbjct: 1145 LELVKK----DAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQ------- 1193
Query: 1471 RATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPAT------AEREKLIAELGR 1524
K +E L+E+ ++L+ + Q ++ I +L ++ AE + LI +
Sbjct: 1194 ----KQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASL 1249
Query: 1525 KEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHIL 1584
K S +++ +A + + ++ E LK ++ ++ V +E+
Sbjct: 1250 KGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAA 1309
Query: 1585 HHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQD-DSLSSLLVK 1643
+ S +K +++KQ NK +++ E A+Q+ + L L+ +
Sbjct: 1310 KAE-QATVTSEFESYKVRVHNVLKQQK-----NKS---MSQAETEGAKQEREHLEMLIDQ 1360
Query: 1644 LKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQC 1703
LK QD + +I +++ ++ L E H +++ ++ +L+ L Q E+
Sbjct: 1361 LKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMM 1420
Query: 1704 LKSE-------LQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMT 1756
+KSE L +Q E + +R+L E + + ++Q + L +L+ E T
Sbjct: 1421 MKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPT 1480
Query: 1757 AAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKT-SKNRENSL 1815
R ++ Q +L ++ D ++ T + E + E T S + ++
Sbjct: 1481 T----RSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGM----ETTDTESVSSASTY 1532
Query: 1816 TDNLNDLNNELQKK-QKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDN-KQSL 1873
T +L L N + K + KEE+ Q+ + L L+ T+
Sbjct: 1533 TQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQ 1592
Query: 1874 IEELQRKVKKLENQLEGKVEEVDLKPMK 1901
I+ L+ ++++LE E + +L+ +K
Sbjct: 1593 IKLLKSEIRRLERNQEREKSAANLEYLK 1620
Score = 158 bits (399), Expect = 7e-38
Identities = 293/1401 (20%), Positives = 586/1401 (41%), Gaps = 182/1401 (12%)
Query: 1149 KVEVSKLREISDIARRQVEILNAQQQ---SRDKEVESLRMQLLDYQAQSDEKSLIAKLHQ 1205
K+E ++ A++Q+ ++ + +KE+E LR + + K+L +L
Sbjct: 21 KLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERL-- 78
Query: 1206 HNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQ 1265
+A L K E+ L ++ N++++Q++++ + A E + +
Sbjct: 79 --------DALLLEKAETEQQCLS-LKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVK 129
Query: 1266 TIQSLRRQFSGALPLAQQEK--FSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMEL 1323
I++L+ + ++K K + + N +L++ +++K N++ E+E
Sbjct: 130 EIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEK 189
Query: 1324 KLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIIS--- 1380
G EE I L LQ+ +L+ + KE + L NII
Sbjct: 190 IRPGFEEQI---------------------LYLQK-QLDATTDEKKETVTQLQNIIEANS 227
Query: 1381 -EYERTISSLEEEIVQQNKFHEER--------QMAWDQREVDLERQLDIFDRQQNEI--- 1428
Y++ I+SL+EE++Q H+E + + + E ++ + ++ + +
Sbjct: 228 QHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEAS 287
Query: 1429 -LNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESA 1487
N +K+E ++ + +I ++EN + K LE+ LKE ES
Sbjct: 288 EKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELES- 346
Query: 1488 LRLAEQNILSRDKV--INELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANM 1545
Q+ + +D+V +N L+L+L A+ K R+++E K + L + +
Sbjct: 347 -----QHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVI 401
Query: 1546 QARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWD 1605
+ ++ + K++ +E+ E + + ++H++++ L+ +DS K
Sbjct: 402 EKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETF--LSDSEKEK------- 452
Query: 1606 LMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEF 1665
+ L Q + EQ ++L + ++ + E REI E+ E
Sbjct: 453 ---------------LTLMFEIQGLKEQCENLQQ---EKQEAILNYESLREIMEILQTEL 494
Query: 1666 ENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRN 1725
++ + E ++ ++V +L+ L + E L + + N + + +
Sbjct: 495 GESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKL--LSQQE 552
Query: 1726 LVERLKSQLALKEKQQK-ALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHT 1784
LV L++ +K Q+K + L R M E +I S T +K+ +N +
Sbjct: 553 LVPELEN--TIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEM 610
Query: 1785 RELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEID 1844
+ E +L+L + ++ + + L +N+L L++ L+EK++ D
Sbjct: 611 DNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEET-------LKEKDQND 663
Query: 1845 QENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKN 1904
Q+ ++L Q+K L+ + L+ +SL EE K+ + QL +E V L ++
Sbjct: 664 QKLEKLMVQMKVLSEDKE--VLSAEVKSLYEE-NNKLSSEKKQLSRDLE-VFLSQKEDVI 719
Query: 1905 AKEELIRWEEGKKWQAKIEGIRNKLKEKEG--EVFTLTKQLNTLKDLFAKA--DKEKLTL 1960
KE + + E+ + + + NKL E E ++F T+ LK++ ++ D E+ +
Sbjct: 720 LKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDV 779
Query: 1961 QRKLKTTGMTVDQV----------LGIRALESEKEL-----------EELKKRNLDLEND 1999
L+ G ++ ++ + LE EKE+ EELK D E +
Sbjct: 780 VNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQE 839
Query: 2000 ILYMRAHQA---LPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQ 2056
+ +R ++++ DL L+ + EK LE Q + S + +S+ H +
Sbjct: 840 KVLLRKELEEIQSEKEALQSDL-LEMKNANEKTR-LENQNLLIQVEEVSQTCSKSEIHNE 897
Query: 2057 REQELQKE--NLKLSSENIELKFQ------LEQANKDLPRLKNQ----VRDLKEMCEFLK 2104
+E+ KE NLK E EL+ + L+ + P +KN V++L+E E L+
Sbjct: 898 KEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE 957
Query: 2105 KEKAEVQRKLGHVR-GSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILT---- 2159
KE E + K+ ++ + ++ K + K +K+ +E ++ E +QL + L
Sbjct: 958 KECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAE 1017
Query: 2160 SEKMANIEQENEKLKAELEKLKA----HLGHQLSMHYESKTKGTEKIIAENERLRKELKK 2215
S K +E E + + ++EK +A H L+ + T E I ++NE L ++
Sbjct: 1018 SYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 1077
Query: 2216 ETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAE---------SRGPQLEGADSKSW 2266
A+ L + LE+ K V E ++LQ + + +L+ K
Sbjct: 1078 LQSNAKLLEV--QILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEK 1135
Query: 2267 KSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKH 2326
K + T +K+ N I D ++L+KE ++ N EDLEQ+IKI K
Sbjct: 1136 KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQK- 1194
Query: 2327 VPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIK 2386
+ ++ L+ E+ L+ + Q + EK I Q+ + A+S + D L
Sbjct: 1195 -----QKQETLQEEITSLQSSVQQYE-EKNTKIKQLLVKTKKELADSKQAETDHL----- 1243
Query: 2387 DLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVK 2446
L+ LK +LE + E+ K+ +L + E LK + ++ + +++V
Sbjct: 1244 ILQASLK-GELEASQQQVEVYKI--QLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVT 1300
Query: 2447 KLSEQLGVELTSPVAASEEFE 2467
L E+ + EFE
Sbjct: 1301 ALQEECRAAKAEQATVTSEFE 1321
Score = 156 bits (395), Expect = 2e-37
Identities = 379/1751 (21%), Positives = 732/1751 (41%), Gaps = 275/1751 (15%)
Query: 790 ELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLED 849
E E +E + K + + D + A+ +LL ++ +E++ + + IK K+++ED
Sbjct: 52 EKEIEELRSKPVTEGTGDIIK--ALTERLDALLLEKAETEQQCLSLKKENIKM-KQEVED 108
Query: 850 QVQQ--DAIKVKEYN--NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVE 905
V + DA K E + N + ++ +E+ + ++ S LQ K L T +E
Sbjct: 109 SVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQ---KQLEEAMNTQLE 165
Query: 906 LERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELA 965
L QL+ +N + N + ++ E+ EKI F+E ++ LQK +D + + E
Sbjct: 166 LSEQLKFQNNSEDN-VKKLQEEI-EKIR--PGFEEQILY----LQKQLDATTD-EKKETV 216
Query: 966 NKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENIS-LKEQVESINKELEITKEKLHTI 1024
+ N + A + + N L + L+ + E + L Q+E+ KE E KL+ +
Sbjct: 217 TQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNEL 276
Query: 1025 EQ-------AWEQETKLGNESSMDKAKKSITNSD----IVSISKKITMLEMKELNERQRA 1073
++ A E+ + E ++ +K+ +N++ I SI + + +NE+ +
Sbjct: 277 KENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVK- 335
Query: 1074 EHCQKMYEHLRTSLKQMEERNFELETKFAELT----KINLDAQKVEQML---RDELADSV 1126
HL +LK++E ++ L+ + + K+ +DAQ ++ R++L +
Sbjct: 336 --------HLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKI 387
Query: 1127 SKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQ 1186
++ + + Q + +EK + EL + + R+V+ L Q Q KE+ L
Sbjct: 388 NELLLAKEEQGCV-IEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQ---KEISELNET 443
Query: 1187 LLDYQAQSDEKSL---IAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLD 1243
L ++ ++ +L I L + +LQ + A+ ES+ ++ ++ K+
Sbjct: 444 FLS-DSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKIS 502
Query: 1244 EKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQ--NDKLKIM 1301
++ +++ + +A + + Q LR F+ +++ +T+ +LQ N+KL
Sbjct: 503 QEFESMK------QQQASDVHELQQKLRTAFT------EKDALLETVNRLQGENEKLLSQ 550
Query: 1302 QEM--------KNSQQEHRNMENKTLEMELKLKGLEELISTLKDTK---------GAQKV 1344
QE+ KN Q+++ + + LK LE I++L + K +++
Sbjct: 551 QELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEM 610
Query: 1345 INWHMKIEELRLQELKLNRELVKDKEE-IKYLNNIISEYERTISSLEEEIVQQNKFHEER 1403
N+H K E +E +L EL K E+ I+Y + + + LEE + ++++
Sbjct: 611 DNFHKKCE----REERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQN---- 662
Query: 1404 QMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKEN 1463
DQ+ L Q+ + + + + E + L LE+ L + ++
Sbjct: 663 ----DQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKED- 717
Query: 1464 IRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELG 1523
+IL+ T LE+KL+ L + EQ+ L++ + NE +L + + E+G
Sbjct: 718 --VILKEHIT--QLEKKLQ-----LMVEEQDNLNK-LLENEQVQKLFVKTQLYGFLKEMG 767
Query: 1524 RKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHI 1583
+ E + Q + A++N+ E+ +QR EK E ++EI EE +
Sbjct: 768 SEVSEDSEEKDVVNVLQAVGESLAKINE-EKCNLAFQRD-EKVLELEKEIKCLQEESVVQ 825
Query: 1584 LHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSS--LL 1641
L D K L+++ + + K ++ +E A + L + LL
Sbjct: 826 CEELKSLLRDYEQEKV------LLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLL 879
Query: 1642 VKLKKVSQDLERQREITELK---VKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQ 1698
+++++VSQ + E + +KE EN+K L++ E++ +AE+ LL S
Sbjct: 880 IQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQK---ELRDRRAEL----ILLKDSL 932
Query: 1699 KESQCLKSELQAQKEANSRAPTTTMRNLVERLKS-QLALKEKQQKALSRALLELRAEM-- 1755
+S +K++ P ++++ L E++++ + KEK++K L+ ++A+
Sbjct: 933 AKSPSVKND-----------PLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKEL 981
Query: 1756 ------TAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLL---KLKEALK 1806
T +E + S S+K+ + R+L E LL K E L
Sbjct: 982 DSSRKETQTVKEELESLRSEKDQ-------LSASMRDLIQGAESYKNLLLEYEKQSEQLD 1034
Query: 1807 TSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPL 1866
K R N+ + DL +L+ N L + E I+ +N++L +I+ L S + +
Sbjct: 1035 VEKERANNFEHRIEDLTRQLR------NSTL-QCETINSDNEDLLARIETLQSNAKLLEV 1087
Query: 1867 TDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIR 1926
I E+QR ++ +LE + K KE+ KE E ++ Q +++ +
Sbjct: 1088 Q------ILEVQRAKAMVDKELEAE------KLQKEQKIKEHATTVNELEELQVQLQKEK 1135
Query: 1927 NKLKEKEGEVFTLTK--QLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEK 1984
+L++ E+ + K Q TL ++ AD E+L + K T I LE E
Sbjct: 1136 KQLQKTMQELELVKKDAQQTTLMNMEI-ADYERLMKELNQKLTNKNNK----IEDLEQEI 1190
Query: 1985 ELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKD-TYSK 2043
++++ K+ L E L Q +++ ++ L ++ + K A KQ D +
Sbjct: 1191 KIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTK----KELADSKQAETDHLILQ 1246
Query: 2044 PSISGIESDDHCQREQELQKENL-KLSSENIE----LKFQLEQANKDLPRLKNQVRDLKE 2098
S+ G + Q++ E+ K L +++SE + LK EQ + L + +V L+E
Sbjct: 1247 ASLKG--ELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQE 1304
Query: 2099 MCEFLKKEKAEV-----------------QRKLGHVRGSGRSGKTIPE-LEKTIGLMKKV 2140
C K E+A V Q+ + K E LE I +K
Sbjct: 1305 ECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIK 1364
Query: 2141 VEKVQRENEQLKKASGILTSEKMANIEQENEKLK------AELEKLKAHLGHQLSMHYES 2194
++ Q + L SE +E+ N+ L+ AEL + + + M
Sbjct: 1365 LQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSE 1424
Query: 2195 KTKGTEKIIAENERLRKELKKET-DAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAES 2253
T+ ++ ++NE LR + + E+ R L+ KM QL Q
Sbjct: 1425 HTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQL------FQLKNE 1478
Query: 2254 RGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSI--TDLKQLVKEATEREQKVN 2311
+ + +S K++ R + L ++ T ++ + + TD TE +
Sbjct: 1479 PTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTD--------TESVSSAS 1530
Query: 2312 KYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGA 2371
Y + LEQ L + PE + E L + K EL+ ++
Sbjct: 1531 TYTQSLEQ----LLNSPE-TKLEPPL-----------WHAEFTKEELVQKL--------- 1565
Query: 2372 ESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNY 2431
ST AD L +++ E + L E+IK LK E+ + + +E E N
Sbjct: 1566 SSTTKSADHLNGLLRETEATNAI-------LMEQIKLLKSEIRRLERN--QEREKSAANL 1616
Query: 2432 KEEVKKNILLE 2442
E KN+LL+
Sbjct: 1617 --EYLKNVLLQ 1625
Score = 141 bits (355), Expect = 9e-33
Identities = 251/1232 (20%), Positives = 516/1232 (41%), Gaps = 176/1232 (14%)
Query: 38 NELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENE 97
N +K+ +++N ++L ++Q +K E ++ EE+ F N+LK +++N
Sbjct: 559 NTIKNLQEKNGVYLLSLSQRDTMLKELE-----GKINSLTEEKDDFINKLKNSHEEMDNF 613
Query: 98 LEMAQQSAGGRDTRFLRN------EICQLEKQLEQKDRELEDMEKELEKEKKVNEQ---- 147
+ + R+ R + + Q +LEQK EL +E KEK N+Q
Sbjct: 614 HKKCE-----REERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEK 668
Query: 148 LALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGED---SDY 204
L ++ + + L E K L ++N +L + +KQ+ E LS++ ED ++
Sbjct: 669 LMVQMKVLSEDKEVLSAEVKSLYEENNKLSSE----KKQLSRDLEVFLSQK-EDVILKEH 723
Query: 205 RSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIV 264
+QL KK +++ D + L E NE +VQ ++ L ++EM E + K +V
Sbjct: 724 ITQLEKKLQLMVEEQDNLNKLLE-NE--QVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVV 780
Query: 265 HQTDNVIDQLKKEN----------DHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWK 314
+ V + L K N D L++++ L+ ++ + ++ E+ K
Sbjct: 781 NVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEK 840
Query: 315 LILSSKDDEIIEYQQMLHNLREKLKNA--QLDADKSNVMALQQGIQERDSQIKMLTEQVE 372
++L + +EI ++ L + ++KNA + + N++ + + + S+ ++ E+ +
Sbjct: 841 VLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEK 900
Query: 373 QYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEA 432
+ KE E ++E + EL+ + L + + K S + KE E E E
Sbjct: 901 CFIKEHENLKPLLE--QKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEK 958
Query: 433 DAREKDKEL-------VEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKE 485
+ +EK++++ V+A K L +++ + +++ K+Q+ R++ +
Sbjct: 959 ECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAES 1018
Query: 486 INKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESL 545
L L+ ++ + +ER + DLT + L+ + ++N+ LL IE+L
Sbjct: 1019 YKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETL 1078
Query: 546 EEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEA 605
+ L+ +I ++ +R K L E L + I + A
Sbjct: 1079 QSNAKLLEVQILEV--QRAKAMVDKELEAEKLQKEQKIKE------------------HA 1118
Query: 606 QSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDP 665
+ N EL E + L++ + + K +L ELV+++ Q M + + + K+
Sbjct: 1119 TTVN-----ELEELQVQLQKEKKQLQKTMQEL-ELVKKDAQQTTLMNMEIADYERLMKEL 1172
Query: 666 DVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKE 725
+ K + I LE+ + I+ + E + + L++ V Q +N +++Q L +++KE
Sbjct: 1173 NQKLTNKNNKIEDLEQEIK-IQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKE 1231
Query: 726 AINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLI 785
+ Q + DHL + SL + E S Y I
Sbjct: 1232 LADSKQ------AETDHLILQASLKGELEASQ--------------------QQVEVYKI 1265
Query: 786 HLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKE----------YLSEKETWKT 835
L + K K ++L+ S E + R + + + + L +E SE E++K
Sbjct: 1266 QLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKV 1325
Query: 836 E-SKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEK 894
+K++K K Q + + K + + L+M D++K L ++ + + +
Sbjct: 1326 RVHNVLKQQKNKSMSQAETEGAKQEREH-----LEMLIDQLKIKLQDSQNNLQINVSELQ 1380
Query: 895 SLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVD 954
+L ++ TL+E + K E +S EAE+ EK+ +Q E + K +
Sbjct: 1381 TLQSEHDTLLE-------RHNKMLQETVSKEAELREKLCSIQ--SENMMMK-------SE 1424
Query: 955 NSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKEL 1014
++ ++S+L Q L +RD + HL+ E+ ++ VE++ ++L
Sbjct: 1425 HTQTVSQL---TSQNEVLRNSFRD-------------QVRHLQEEH---RKTVETLQQQL 1465
Query: 1015 EITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAE 1074
+ +L ++ + + ++ S+ K + N+D+ + E E E E
Sbjct: 1466 SKMEAQLFQLKNEPTTRSPVSSQQSL-KNLRERRNTDLPLLDMHTVTREEGEGMETTDTE 1524
Query: 1075 HCQ--KMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSD 1132
Y L E E AE TK L QK+ + AD ++ + +
Sbjct: 1525 SVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEEL-VQKLSSTTKS--ADHLNGLLRE 1581
Query: 1133 ADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQA 1192
+ + +E ++K+ S++R + R+ N + ++++ +Q + +
Sbjct: 1582 TEATNAILME----QIKLLKSEIRRLERNQEREKSAANLEY------LKNVLLQFIFLKP 1631
Query: 1193 QSDEKSLIAKLHQHNVSLQLSEATALGKLESI 1224
S+ + L+ + N LQLS GKL ++
Sbjct: 1632 GSERERLLPVI---NTMLQLSPEEK-GKLAAV 1659
Score = 107 bits (268), Expect = 1e-22
Identities = 223/1086 (20%), Positives = 454/1086 (41%), Gaps = 157/1086 (14%)
Query: 1439 TGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSR 1498
TG +LP + ++ A K+ + +I + ++ C LE++++E S +
Sbjct: 17 TGKSKLETLPKEDLIKFA----KKQMMLIQKAKSRCTELEKEIEELRS-----KPVTEGT 67
Query: 1499 DKVINELRLRLPAT----AEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEE 1554
+I L RL A AE E+ L ++ ++ K ++ M + E+
Sbjct: 68 GDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQE-----VEDSVTKMGDAHKELEQ 122
Query: 1555 VLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPV 1614
Y + +E + E + K+ ED L +LE ++ L +Q +
Sbjct: 123 SHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQ--------- 173
Query: 1615 PTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQE 1674
N + ++++ + + ++ L+K L+ + + V + +NI +
Sbjct: 174 --NNSEDNVKKLQEEIEKIRPGFEEQILYLQK---QLDATTDEKKETVTQLQNIIEANSQ 228
Query: 1675 NHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQL 1734
+++ + ++ E+ LK + + KE C +++A + + A + L E L Q
Sbjct: 229 HYQKNINSLQEELLQLKAIHQEEVKELMC---QIEASAKEHE-AEINKLNELKENLVKQC 284
Query: 1735 ALKEKQ-QKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVED 1793
EK QK L LR + A ++ I + +E + V+Q+V+ + L+ +++
Sbjct: 285 EASEKNIQKKYECELENLRKATSNANQDNQICSILLQE-NTFVEQVVNEKVKHLEDTLKE 343
Query: 1794 LNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQK----AYNKILREKEEIDQENDE 1849
L LK+ + N + L + + +E +++ N++L KEE ++
Sbjct: 344 LESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEK 403
Query: 1850 LKRQIKRLTSGLQGKPLTDNK--QSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKE 1907
LK ++ L N+ QSL E+ Q+++ +L E+ L M E +
Sbjct: 404 LKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLK 463
Query: 1908 ELIRWEEGKKWQAKI---------EGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKL 1958
E + +K +A + E ++ +L E G++ +++ ++K A E
Sbjct: 464 EQCENLQQEKQEAILNYESLREIMEILQTELGESAGKI---SQEFESMKQQQASDVHE-- 518
Query: 1959 TLQRKLKTTGMTVDQVLG-IRALESEKE--------LEELKK--RNLDLENDILYMRAHQ 2007
LQ+KL+T D +L + L+ E E + EL+ +NL +N + + Q
Sbjct: 519 -LQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQ 577
Query: 2008 ALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDH---CQREQELQKE 2064
RD+++++L + K+++L ++ D +K S E D+ C+RE+ L E
Sbjct: 578 ---RDTMLKEL-------EGKINSLTEE-KDDFINKLKNSHEEMDNFHKKCEREERLILE 626
Query: 2065 NLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSG 2124
K + I+ +LEQ +V +L E KEK + +KL
Sbjct: 627 LGKKVEQTIQYNSELEQ----------KVNELTGGLEETLKEKDQNDQKL---------- 666
Query: 2125 KTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHL 2184
EK+ + + L + +L++E + ++ +EN KL +E ++L L
Sbjct: 667 -----------------EKLMVQMKVLSEDKEVLSAE-VKSLYEENNKLSSEKKQLSRDL 708
Query: 2185 GHQLSM--------HYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEK 2236
LS H K + ++ E + L K L E + +KL + L E
Sbjct: 709 EVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLL--ENEQVQKLFVKTQLYGFLKEM 766
Query: 2237 MTVQLEETGKR--LQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSIT 2294
+ E++ ++ + ++ G L + + + + K+ ELE +I
Sbjct: 767 GSEVSEDSEEKDVVNVLQAVGESLAKINEEKCN---LAFQRDEKVLELEKEI-------- 815
Query: 2295 DLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETE-QGLKRELQVLRLANHQLDK 2353
K L +E+ + +++ D EQ+ +L+ E ++E + L+ +L ++ AN +
Sbjct: 816 --KCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRL 873
Query: 2354 EKAELIHQIEANKDQSGAESTIPDADQL-----KEKIKDLETQLKMSDLEKQH--LKEEI 2406
E L+ Q+E Q+ ++S I + + E +K L Q ++ D + LK+ +
Sbjct: 874 ENQNLLIQVE-EVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSL 932
Query: 2407 KKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEF 2466
K ++N S +E+E+ N ++E K+ K+K ++ + EL S ++
Sbjct: 933 AK-SPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTV 991
Query: 2467 EDEEES 2472
++E ES
Sbjct: 992 KEELES 997
Score = 76.6 bits (187), Expect = 3e-13
Identities = 140/682 (20%), Positives = 277/682 (40%), Gaps = 98/682 (14%)
Query: 8 KEIMKVDPDDLPRQEELADNLLISLSKV-EVNELKSEKQENVIHLFR-ITQSLMKMKAQ- 64
K+ + DL + E NLL+ K E +++ E+ N H +T+ L Q
Sbjct: 1002 KDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQC 1061
Query: 65 -----EVELALEEVEKAGEEQAKFENQL----KTKVM-KLENELEMAQQSAGGRDTRFLR 114
+ E L +E E Q+ + K M E E E Q+ ++
Sbjct: 1062 ETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTV 1121
Query: 115 NEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNE 174
NE+ +L+ QL+++ ++L+ +ELE KK +Q L N E + ++ N++L KN
Sbjct: 1122 NELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNN 1181
Query: 175 QLCQDIIDYQKQIDSQKETLLSRRGEDSDYRS---QLSKKNYELIQYLDEIQTLTEANEK 231
+ I D +++I QK+ + + E + +S Q +KN ++ Q L + + +++
Sbjct: 1182 K----IEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQ 1237
Query: 232 IEVQNQEMRKNLEESVQEMEKMTDEYN-RMKAIVHQTDNVIDQLKKENDHYQLQVQELTD 290
E + ++ +L+ ++ ++ + Y ++ I + + + LK + +Q +
Sbjct: 1238 AETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQ 1297
Query: 291 LLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNV 350
+ + EE AK E+ ++ E Y+ +HN+ ++ KN KS
Sbjct: 1298 RVTALQEE------CRAAKAEQ-----ATVTSEFESYKVRVHNVLKQQKN------KSMS 1340
Query: 351 MALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQ 410
A +G ++ ++ML +Q++ ++D +N LQ N Q H
Sbjct: 1341 QAETEGAKQEREHLEMLIDQLK----------IKLQDSQNNLQINVSELQTLQSEH---- 1386
Query: 411 STLDILKEKTKEAERTAELAEADAREKDKEL-VEALKRLKDYESGVYGLEDAVVEIKNCK 469
D L E+ + + EA+ REK + E + ++ V L ++N
Sbjct: 1387 ---DTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRN-- 1441
Query: 470 NQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQ 529
RD ++ L +E K + L + EA ++ EP T ++ ++ K+L++
Sbjct: 1442 ---SFRD-QVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRE- 1496
Query: 530 QYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRI 589
R + L ++ ++ E G+ T D TE++S
Sbjct: 1497 --RRNTDLPLLDMHTVTREE-------------------GEGMETTD---TESVSSASTY 1532
Query: 590 SERKLDLLSLKNMSEAQSK-----NEFLSRELIEKERDLERSRTVIAKFQNKLKELVEEN 644
++ L L N E + + EF EL++K +S L+E N
Sbjct: 1533 TQ---SLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSAD---HLNGLLRETEATN 1586
Query: 645 KQLEEGMKEILQAIKEMQKDPD 666
L E +K + I+ ++++ +
Sbjct: 1587 AILMEQIKLLKSEIRRLERNQE 1608
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 177 bits (448), Expect = 1e-43
Identities = 348/1688 (20%), Positives = 698/1688 (41%), Gaps = 217/1688 (12%)
Query: 800 NLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVK 859
NL + LE++ +K A + S + E LS S K E R LE Q
Sbjct: 142 NLNEDLENFLQK-APVPSTCSSTFPEELSPP------SHQAKREIRFLE---LQKVASSS 191
Query: 860 EYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEK--- 916
NN L+ + M IL ++ L+ K L + + ELE +L EN K
Sbjct: 192 SGNNFLSG--SPASPMGDILQTPQFQMRRLK---KQLADERSNRDELELELA-ENRKLLT 245
Query: 917 QKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLS-ELELANKQYNELTAK 975
+K+ ++M + +++ L + + + L+++ D + SL+ L KQ +L +
Sbjct: 246 EKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTE 305
Query: 976 YRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLG 1035
+ +K N L + +L E S +Q++ EL T+E ++ E++ +L
Sbjct: 306 KSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNEL--TEEHSKATQEWLEKQAQLE 363
Query: 1036 NESSMDKAKKSITNSDIVSISKKITMLE--MKELNERQRAEHCQKMYEHLRT-SLKQ--- 1089
E S K + K++ LE + +L + E + + + L+ +LKQ
Sbjct: 364 KELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAA 423
Query: 1090 -MEERNFELETKFAELTKINLDAQKVEQMLR----DELADSVSKAVSDADRQ-RILELEK 1143
+ N +L+ + E+ + Q+ + + +E +S ++D L K
Sbjct: 424 TLAANNTQLQAR-VEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAK 482
Query: 1144 NEMELKVEVSKLREISDIARRQVEI--LNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIA 1201
E+E + R + +A E+ LNA Q +D+E+ L+ Q + QAQ +
Sbjct: 483 EELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQ----- 537
Query: 1202 KLHQHNVSLQLSEATALG---KLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRN 1258
+LQ E + G ++E ++S L++ E + +++ EK++A +
Sbjct: 538 -------TLQQQEQASQGLRHQVEQLSSSLKQKE----QQLKEVAEKQEATRQDHAQQLA 586
Query: 1259 RAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEH-RNMENK 1317
A R+ SLR + + L EK +++ +L++ E ++S Q + +
Sbjct: 587 TAAEEREA--SLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQRE 644
Query: 1318 TLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNN 1377
E+ K++ L+ + T + + + ++ EL LQ L+ ++ +KE + +
Sbjct: 645 KAELSRKVEELQACVETARQEQHEAQA-----QVAELELQ-LRSEQQKATEKERVAQEKD 698
Query: 1378 IISEYERTISSLEEEI-VQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFE 1436
+ E + +L+E + V + EE++ AA E
Sbjct: 699 QLQEQ---LQALKESLKVTKGSLEEEKR-------------------------RAADALE 730
Query: 1437 EATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNIL 1496
E I + + +E R+ KE + E RA K LE +L++ A + AE +L
Sbjct: 731 EQQRCISELKAETRSLVEQHKRERKE----LEEERAGRKGLEARLQQLGEAHQ-AETEVL 785
Query: 1497 SRDKVINELRLRLPATAEREKLIAELG--RKEMEPKSHHTLKIAHQTIANMQARLNQKEE 1554
R+ + + + A +E E+L+ E+ R+ E + A Q +L +E
Sbjct: 786 RRE-LAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYG----AMFQEQLMTLKE 840
Query: 1555 VLKKYQRLLEKAREEQREI-------VKKHEEDLHILHHRLEL---QADSSLNKFKQTAW 1604
+K ++ L++A+E+ I + + + +L LH L Q + ++ A
Sbjct: 841 ECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD 900
Query: 1605 DLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQRE-ITELKVK 1663
DL T+K RL + + EQ ++ S LVK + D RQ E + E + +
Sbjct: 901 DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGD--RQPEWLEEQQGR 958
Query: 1664 EFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTM 1723
+F + + LQ E E +++ E+E L+ L +SQ + Q E + Q+E T
Sbjct: 959 QFCSTQAALQAM-EREAEQMGNELERLRAALMESQGQQQ----EERGQQEREVARLTQER 1013
Query: 1724 RNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAH---------L 1774
L + A + + + L AL E R E A +E + A ++KE L
Sbjct: 1014 GRAQADLALEKAARAELEMRLQNALNEQRVEF-ATLQEALAHALTEKEGKDQELAKLRGL 1072
Query: 1775 NVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYN 1834
QI + EL+ V+ L E L K ++ + ++ +L+ + +
Sbjct: 1073 EAAQI--KELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVS 1130
Query: 1835 KILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEE 1894
K+ ++ ++ ++ D L+R ++ +++ E ++ L+ QLE K +E
Sbjct: 1131 KLEQQCQKQQEQADSLERSLEA-------------ERASRAERDSALETLQGQLEEKAQE 1177
Query: 1895 VDLKPMKEKNAKEELIRW--------EEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTL 1946
+ +A+ EL + + +W+A++ R + + K + +L ++++ L
Sbjct: 1178 LGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSIL 1237
Query: 1947 KDLFAKADKEKLTLQRKLKTTG---MTVDQVLGIRALESEKELEELKKRNLDLENDILYM 2003
+ + E L+R + +++ L + E+ +R+ L ++ +
Sbjct: 1238 NRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL 1297
Query: 2004 RAH---QALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQE 2060
R Q + +++ ++L Q +E L+ K + ++S ++ + Q
Sbjct: 1298 REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEH--TSTQA 1355
Query: 2061 LQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGS 2120
L E L ++++ + Q EQA + R + ++ K+ L+ E QR+LG +
Sbjct: 1356 LVSE--LLPAKHLCQQLQAEQAAAE-KRHREELEQSKQAAGGLRAELLRAQRELGELIPL 1412
Query: 2121 GRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMA--------------NI 2166
+ + E E+T ++ + LKKA G+L E +
Sbjct: 1413 RQK---VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVEL 1469
Query: 2167 EQENEKLKAELEKLKAHLGHQLS---MHYESKTKGTEKIIAENE----RLRKELKKETDA 2219
+Q EK EL ++A +L+ +S + E + A+ E ++ +E ++ +
Sbjct: 1470 DQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEE 1529
Query: 2220 AEKLRIAKNNLEILNEKMTVQLEETGKRL----QFAESRGPQLEGADSKSWKSIVVTRMY 2275
+KL LE+ + T Q+EE K+L Q ++ + +L+ ++ +S +
Sbjct: 1530 RQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRL 1589
Query: 2276 ETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQ 2335
+ +L EL+ +++K Q+ K +++A + N++L++Q+
Sbjct: 1590 QAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQL-------------- 1635
Query: 2336 GLKRELQVLRLANHQLDKEKAELIHQI-EANKDQSGAESTIPDADQLKEKIKDLETQLKM 2394
R L+ L+ N +L E L H++ +A AE T L +++ LE Q+
Sbjct: 1636 ---RSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQT---CRHLTAQVRSLEAQVAH 1689
Query: 2395 SDLEKQHL 2402
+D + + L
Sbjct: 1690 ADQQLRDL 1697
Score = 154 bits (390), Expect = 8e-37
Identities = 342/1659 (20%), Positives = 668/1659 (40%), Gaps = 298/1659 (17%)
Query: 100 MAQQSAGGRDTRF-LRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLA---LRNEEA 155
+ +Q A R R L E+ + K L +KD ++ M++ +++ +NE+ A L +E
Sbjct: 219 LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKEL 278
Query: 156 ENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYEL 215
E K RL + +Q CQD+ + Q+D + L E+ D +L + L
Sbjct: 279 EELRDKNESLTMRLHETLKQ-CQDLKTEKSQMDRKINQLSE---ENGDLSFKLREFASHL 334
Query: 216 IQYLDEIQTLTEANEK-----IEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNV 270
Q D + LTE + K +E Q Q + K L ++Q+ + + ++ ++ + Q +
Sbjct: 335 QQLQDALNELTEEHSKATQEWLEKQAQ-LEKELSAALQDKKCLEEKNEILQGKLSQLEEH 393
Query: 271 IDQLKKE---------NDHYQL---------------QVQELTDLLKSKNEEDDPIMVAV 306
+ QL+ D QL Q+Q ++L+++ + + ++A
Sbjct: 394 LSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAE 453
Query: 307 NAKVEEWKLILSSKDDEIIEYQQMLHNLREKLK----------NAQLDADKSNVMALQQG 356
EE K LSS ++ L +E+L+ AQ+ + S + L
Sbjct: 454 RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNAT 513
Query: 357 IQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDIL 416
IQ++D ++ L +Q + EK + + L+ + Q ++G +++ L
Sbjct: 514 IQQQDQELAGLKQQAK------EKQAQLAQTLQQQEQASQG-------LRHQVEQLSSSL 560
Query: 417 KEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRD 476
K+K ++ + AE EA ++ ++L A E L + +K + K +
Sbjct: 561 KQKEQQLKEVAEKQEATRQDHAQQLATAA------EEREASLRERDAALKQLEALEKEKA 614
Query: 477 REIEILTKEINKL-ELKISDFLDENEALRERVGLEPKTMIDLTEFRNS-KHLKQQQYRAE 534
++EIL +++ E + S +A RE+ L K + E + + +Q+Q+ A+
Sbjct: 615 AKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRK----VEELQACVETARQEQHEAQ 670
Query: 535 NQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKL 594
Q+ E++ E++ +K+ ++AQE+ + E L +T+ + ++ R
Sbjct: 671 AQVAELELQLRSEQQKATEKE--RVAQEKDQLQEQLQALKESLKVTKGSLEEEK--RRAA 726
Query: 595 DLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEI 654
D L + ++ K E +R+++ + + + KEL EE + +G++
Sbjct: 727 DALEEQQRCISELKAE---------------TRSLVEQHKRERKEL-EEERAGRKGLEAR 770
Query: 655 LQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEE 714
LQ + E + ET ++ L + A + +E +QL
Sbjct: 771 LQQLGEAHQ------AETEVLRRELAEAMAAQHTAESE------------CEQLVKEVAA 812
Query: 715 LRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQS-EGSNVVFKGIDLPDGIAPSS 773
R+ +S++E Y + ++ L++E RQ + + GI+ + S
Sbjct: 813 WRERYEDSQQEEAQYGAMFQE---QLMTLKEECEKARQELQEAKEKVAGIE-----SHSE 864
Query: 774 ASIINSQNEY------LIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYL 827
I QNE L LQ+++ KE + + L D L K A + + L
Sbjct: 865 LQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVR 924
Query: 828 SEKETWKTESKTIKEEKRK--------LEDQ--------------VQQDAIKV-KEYNNL 864
E +T S+ + +E + LE+Q ++++A ++ E L
Sbjct: 925 KAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984
Query: 865 LNALQMDSDEMKKILAENSRKITVLQVN----EKSLIRQYTTLVELERQLRKENEKQKNE 920
AL + ++ + R++ L + L + ELE +L+ +Q+ E
Sbjct: 985 RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVE 1044
Query: 921 LLSMEAEVC----EKIGCLQRFKEMAIFKIAALQKVVDNSVSLSEL--ELANKQ------ 968
+++ + EK G Q ++ + A ++++ + ++ +L +LA K+
Sbjct: 1045 FATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASG 1104
Query: 969 ---YNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITK------- 1018
+E + K L S LE +C+ +EQ +S+ + LE +
Sbjct: 1105 SGAQSEAAGRTEPTGPKLEALRAEVSKLEQ-QCQ--KQQEQADSLERSLEAERASRAERD 1161
Query: 1019 EKLHTIE-QAWEQETKLG-NESSMDKAKKSIT--NSDIVSISKKITMLEMKELNERQRAE 1074
L T++ Q E+ +LG ++S++ A++ + + + SK + + RQ AE
Sbjct: 1162 SALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE 1221
Query: 1075 HCQKMYEHLRTSLKQMEERNFELETKFAELTKINL----DAQKVEQMLRDELADSVSKAV 1130
+ L + + + E E + EL ++ + +QK+E+ LR A++ S +
Sbjct: 1222 RKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSA 1281
Query: 1131 SDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDY 1190
A+R L+ EV LRE ++ R E L + S+ + E L +L +
Sbjct: 1282 RAAER---------SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAW 1332
Query: 1191 QAQSDEK-SLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQAL 1249
Q + +K ++ L + S Q + L + A R ++L++ +QA
Sbjct: 1333 QEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAA 1392
Query: 1250 YYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLK----IMQEMK 1305
R E + L + I LR++ + AQQ + K Q LK ++ E
Sbjct: 1393 GGLRAELLRAQRELGELI-PLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEEN 1451
Query: 1306 NSQQEHRNMENKTLEMEL---KLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLN 1362
E N+ + LE+EL + K ++EL + D E RL E++
Sbjct: 1452 RGLGERANLGRQFLEVELDQAREKYVQELAAVRADA--------------ETRLAEVQ-- 1495
Query: 1363 RELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFD 1422
RE E++ + ++YE + EE + +F EERQ Q E QL++F
Sbjct: 1496 REAQSTARELEVMT---AKYEGAKVKVLEE---RQRFQEERQKLTAQVE-----QLEVFQ 1544
Query: 1423 RQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLK 1482
R+Q ++++E + + ++ K ++KLK
Sbjct: 1545 REQT-------------------------------KQVEELSKKLADSDQASKVQQQKLK 1573
Query: 1483 EKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEME-PKSHHTLKIAHQT 1541
++ ++Q +NEL+ +L +++ AE + +ME K+H+ K
Sbjct: 1574 AVQAQGGESQQEAQRLQAQLNELQAQL----SQKEQAAEHYKLQMEKAKTHYDAK----- 1624
Query: 1542 IANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQ 1601
Q+ + L++ R LE+ ++E +E+ + E L H L+ QA + +Q
Sbjct: 1625 --------KQQNQELQEQLRSLEQLQKENKELRAEAER----LGHELQ-QAGLKTKEAEQ 1671
Query: 1602 TAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSL 1640
T L Q + +E VA D L L
Sbjct: 1672 TCRHLTAQ-------------VRSLEAQVAHADQQLRDL 1697
Score = 153 bits (387), Expect = 2e-36
Identities = 307/1562 (19%), Positives = 633/1562 (40%), Gaps = 224/1562 (14%)
Query: 13 VDPDDLPRQEELADNLLISLSKV--EVNELKSEKQENVIHLFRITQSL--MKMKAQEVEL 68
++P +L + ++L + L + + +LK+EK + + ++++ + K +E
Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFAS 332
Query: 69 ALEEVEKA----GEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTR--FLRNEICQLEK 122
L++++ A EE +K + K +LE EL A Q + + L+ ++ QLE+
Sbjct: 333 HLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEE 392
Query: 123 QLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIID 182
L Q L+D + EK + + + L L E + E + L N +L+ + E L
Sbjct: 393 HLSQ----LQDNPPQ-EKGEVLGDVLQL--ETLKQEAATLAANNTQLQARVEML------ 439
Query: 183 YQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKN 242
+ + Q+ LL+ RG + + QLS +L I L++A E++E +Q
Sbjct: 440 -ETERGQQEAKLLAERGHFEEEKQQLSSLITDL---QSSISNLSQAKEELEQASQAHGAR 495
Query: 243 LEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPI 302
L V + T E + A + Q D + LK++ Q Q+ + ++ +
Sbjct: 496 LTAQVASL---TSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTL-------QQQEQA 545
Query: 303 MVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQ---GIQE 359
+ +VE+ L K+ Q L + EK + + D + A ++ ++E
Sbjct: 546 SQGLRHQVEQLSSSLKQKE-------QQLKEVAEKQEATRQDHAQQLATAAEEREASLRE 598
Query: 360 RDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEK 419
RD+ +K Q+E KE +E L+ +LQ A +Q + + Q L K
Sbjct: 599 RDAALK----QLEALEKEKAAK---LEILQQQLQVANEARDSAQTSVTQAQREKAELSRK 651
Query: 420 TKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREI 479
+E + E A + E ++ E +L+ + E E + Q++ +
Sbjct: 652 VEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESL 711
Query: 480 EILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQ--------- 530
++ + + + + +D L+E + + E +++++ + R K L++++
Sbjct: 712 KVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK-RERKELEEERAGRKGLEAR 770
Query: 531 -------YRAENQILLKEI-------ESLEEERLDLKKKI---RQMAQERGKRSATSGLT 573
++AE ++L +E+ + E E L K++ R+ ++ + A G
Sbjct: 771 LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAM 830
Query: 574 TED--LNLTENISQG-DRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVI 630
++ + L E + + E K + +++ SE Q + EL E +L R+ +
Sbjct: 831 FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQ--QNELAELHANLARALQQV 888
Query: 631 AKFQNKLKELVEENKQLEEGM----KEILQ--------------AIKEMQKDPDVKGGET 672
+ + + ++L ++ L+E M KE+ + A +E+ K+P G
Sbjct: 889 QEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAG--- 945
Query: 673 SLIIPSLERLVNAIESKNAEGIFDASLHLKA---QVDQLTGRNEELRQELRES----RKE 725
+R +E + L+A + +Q+ E LR L ES ++E
Sbjct: 946 -------DRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEE 998
Query: 726 AINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLI 785
+++A+ + + + +L + + + L + + Q E L
Sbjct: 999 RGQQEREVARLTQERGRAQADLALEKAARAE----LEMRLQNALNEQRVEFATLQ-EALA 1053
Query: 786 HLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKR 845
H L E E K+++L L LE K Q KE L++KE + E
Sbjct: 1054 HALTEKEGKDQELAKLR-GLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEA- 1111
Query: 846 KLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVE 905
A + + L AL+ + ++++ + + L E+SL E
Sbjct: 1112 ---------AGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSL---ERSL--------E 1151
Query: 906 LERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQ-KVVDNSVSLSELEL 964
ER R E + L E +++G Q A ++AA + KV D+S
Sbjct: 1152 AERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHS-------K 1204
Query: 965 ANKQYNELTAKYRDILQKDNMLVQRTS------NLEHLECENIS--LKEQVESINKELEI 1016
A ++ A+ R ++ N L+ N + LE E S LK V + +++ +
Sbjct: 1205 AEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQK 1264
Query: 1017 TKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHC 1076
+E+L + + + + S+ + S ++ S+ ++ + N RQ
Sbjct: 1265 LEERLRLL------QAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQ 1318
Query: 1077 QKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKV--EQMLRDELADSVSKAVSDAD 1134
+ E L LK +E+ F+ E + L + Q + E + L + + A+
Sbjct: 1319 AERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAE 1378
Query: 1135 RQRILELEKNEMELKVEVSKLR-EISDIARRQVEILNAQQQSRDKE--VESLRMQLLDYQ 1191
++ ELE++ K LR E+ R E++ +Q+ ++E + LR + Y
Sbjct: 1379 KRHREELEQS----KQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASY- 1433
Query: 1192 AQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYY 1251
+++ S++ K H L E LG+ ++ + ++E L+Q ++ Q L
Sbjct: 1434 --AEQLSMLKKAH----GLLAEENRGLGERANLGRQFLEVE-----LDQAREKYVQELAA 1482
Query: 1252 ARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEH 1311
R + R +++ QS R+ + + K+K+++E + Q+E
Sbjct: 1483 VRADAETRLAEVQREAQSTARE------------LEVMTAKYEGAKVKVLEERQRFQEER 1530
Query: 1312 RNMENKTLEMEL----KLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVK 1367
+ + + ++E+ + K +EEL L D+ A KV K++ ++ Q + +E +
Sbjct: 1531 QKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKV--QQQKLKAVQAQGGESQQEAQR 1588
Query: 1368 DKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNE 1427
+ ++ L +S+ E+ + + +++ K H + + +Q + R L+ ++ E
Sbjct: 1589 LQAQLNELQAQLSQKEQAAEHYKLQ-MEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKE 1647
Query: 1428 ILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESA 1487
+ A++ L ++L+ A K KE + A +SLE ++ +
Sbjct: 1648 LRAEAER--------------LGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQ 1693
Query: 1488 LR 1489
LR
Sbjct: 1694 LR 1695
Score = 148 bits (373), Expect = 7e-35
Identities = 358/1796 (19%), Positives = 715/1796 (39%), Gaps = 267/1796 (14%)
Query: 460 DAVVEIKNCKNQIKIRDR------EIEILTKEINKLELKISDFLDEN------------- 500
+AV+++++C IKI DR +IL + +++ + FL +N
Sbjct: 25 EAVLQLQDCSIFIKIIDRIHGTEEGQQILKQPVSERLDFVCSFLQKNRKHPSSPECLVSA 84
Query: 501 EALRERVGLEPKTMIDLTEFRNSKHLK--------QQQYRAENQILLKEIESLEEERLDL 552
+ + E LE M L + ++ K + + +AE ++LK + E+ L+L
Sbjct: 85 QKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQAELAVILKFVLD-HEDGLNL 143
Query: 553 KKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFL 612
+ + Q+ S S E+L S ++R++ L L+ ++ + S N FL
Sbjct: 144 NEDLENFLQKAPVPSTCSSTFPEEL------SPPSHQAKREIRFLELQKVASSSSGNNFL 197
Query: 613 SRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGET 672
S D+ +T + + K+L +E +E E+ + K + + K +
Sbjct: 198 SGSPASPMGDI--LQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTE----KDAQI 251
Query: 673 SLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQ 732
+++ ++RL E + A + L ++L +NE L L E+ K+ + +
Sbjct: 252 AMMQQRIDRLALLNEKQAASPLEPKEL------EELRDKNESLTMRLHETLKQCQDLKTE 305
Query: 733 LAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELE 792
++ + KI+ L +E ++ FK E+ HL Q
Sbjct: 306 KSQMDRKINQLSEENG--------DLSFK------------------LREFASHLQQ--- 336
Query: 793 NKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQ 852
L+D+L + + + S +E+L ++ + E ++K+ LE++ +
Sbjct: 337 --------LQDALNE-------LTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNE 381
Query: 853 QDAIKVKEYNNLLNALQMDSDEMK-KILAENSRKITVLQVNEKSLIRQYTTLVELERQLR 911
K+ + L+ LQ + + K ++L + VLQ+ ++L ++ TL QL+
Sbjct: 382 ILQGKLSQLEEHLSQLQDNPPQEKGEVLGD------VLQL--ETLKQEAATLAANNTQLQ 433
Query: 912 KENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDN-SVSLSELELANKQYN 970
E + E EA++ + G + K+ I LQ + N S + ELE A++ +
Sbjct: 434 ARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHG 493
Query: 971 -ELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWE 1029
LTA+ + + L + ++ + E LK+Q + +L T ++ +
Sbjct: 494 ARLTAQVASLTSE---LTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQ--------Q 542
Query: 1030 QETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMY---EHLRTS 1086
++ G +++ S+ K+ + E+ E E R +H Q++ E S
Sbjct: 543 EQASQGLRHQVEQLSSSLKQ-------KEQQLKEVAEKQEATRQDHAQQLATAAEEREAS 595
Query: 1087 LKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEM 1146
L++ + +LE E L+ + + + +E DS +V+ A R++ EL +
Sbjct: 596 LRERDAALKQLEALEKEKAA-KLEILQQQLQVANEARDSAQTSVTQAQREKA-ELSRKVE 653
Query: 1147 ELKVEVSKLREISDIARRQVEILNAQQQS-RDKEVESLRMQLLDYQAQSDEKSLIAKLHQ 1205
EL+ V R+ A+ QV L Q +S + K E R+ Q Q ++L L
Sbjct: 654 ELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKV 713
Query: 1206 HNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQ 1265
SL+ + A LE + +++A L ++ + + L R + L+Q
Sbjct: 714 TKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQ 773
Query: 1266 TIQS-------LRRQFSGALPL------------------------AQQEK------FSK 1288
++ LRR+ + A+ +QQE+ F +
Sbjct: 774 LGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQE 833
Query: 1289 TMIQLQNDKLKIMQEMKNSQQEHRNMENKT-LEMELKLKGLEELISTLKDTKGAQKVINW 1347
++ L+ + K QE++ ++++ +E+ + L++ + L EL + L + Q+V
Sbjct: 834 QLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANL--ARALQQVQEK 891
Query: 1348 HMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAW 1407
++ ++L L ++ +E+ L ++ + + E+V++ +RQ W
Sbjct: 892 EVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEW 951
Query: 1408 DQRE-----VDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKE 1462
+ + + L +R+ ++ N ++ A Q E + ++ +
Sbjct: 952 LEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQ 1011
Query: 1463 NIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKV-INELRLRLP-ATAEREKLIA 1520
RA EK E +RL QN L+ +V L+ L A E+E
Sbjct: 1012 E-----RGRAQADLALEKAARAELEMRL--QNALNEQRVEFATLQEALAHALTEKEGKDQ 1064
Query: 1521 ELGR-KEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEE 1579
EL + + +E L+ QT+ ++ +L +KE+ +A K E
Sbjct: 1065 ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEA 1124
Query: 1580 DLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSS 1639
L +LE Q +Q D +++S L + AE+D +L +
Sbjct: 1125 -LRAEVSKLEQQCQK-----QQEQADSLERS------------LEAERASRAERDSALET 1166
Query: 1640 LLVKLKKVSQDLERQREITELKVKEFENIKLQLQENH--EDE----VKKVKAEVEDLKYL 1693
L +L++ +Q+L + +E + ++Q++ EDE V + + E E L
Sbjct: 1167 LQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL 1226
Query: 1694 LDQSQKESQCLKSELQAQKEANSR-------APTTTMRNLVERLKSQLALKEKQQKALSR 1746
+ ++E L ++ +KE S+ A + + L ERL+ A +
Sbjct: 1227 ISSLEEEVSILNRQV-LEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAE 1285
Query: 1747 ALLELRAEMTAAAEERIISATSQKEAHLNVQQIVD---RHTRELKTQVEDLNENLLKLKE 1803
LR E+ + EE A Q+ A N++Q + EL +++ E + ++
Sbjct: 1286 RSSALREEVQSLREE----AEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQ 1341
Query: 1804 ALKTSKNRENSLTDNLNDLN------NELQKKQKAYNKILREKEEIDQEND-------EL 1850
AL T + S +++L +LQ +Q A K R +EE++Q EL
Sbjct: 1342 ALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEK--RHREELEQSKQAAGGLRAEL 1399
Query: 1851 KRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLE------GKVEEVDLKPMKEKN 1904
R + L + + ++ ++L+ + QL G + E + + N
Sbjct: 1400 LRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERAN 1459
Query: 1905 AKEELIRWE---EGKKWQAKIEGIR----NKLKEKEGEVFTLTKQLNTLKDLF----AKA 1953
+ + E +K+ ++ +R +L E + E + ++L + + K
Sbjct: 1460 LGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKV 1519
Query: 1954 DKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILY----MRAHQAL 2009
+E+ Q + + V+Q L + E K++EEL K+ D + ++A QA
Sbjct: 1520 LEERQRFQEERQKLTAQVEQ-LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQ 1578
Query: 2010 PRDSVVEDLHLQNRY--LQEKL---------HALEKQFSKDTYSKPSISGIESDDHCQRE 2058
+S E LQ + LQ +L + L+ + +K Y E + +
Sbjct: 1579 GGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSL 1638
Query: 2059 QELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKL 2114
++LQKEN +L +E L +L+QA + R L L+ + A ++L
Sbjct: 1639 EQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQL 1694
Score = 146 bits (369), Expect = 2e-34
Identities = 301/1461 (20%), Positives = 604/1461 (41%), Gaps = 242/1461 (16%)
Query: 1135 RQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQS 1194
++++ + N EL++E+++ R++ + + +I QQ+ ++ L + A
Sbjct: 220 KKQLADERSNRDELELELAENRKL--LTEKDAQIAMMQQR-----IDRLALLNEKQAASP 272
Query: 1195 DEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARL 1254
E + +L N SL + +L + Q ++ ++++K+++ +
Sbjct: 273 LEPKELEELRDKNESLTM-------RLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSF 325
Query: 1255 EGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNM 1314
+ R A HL+Q +L E+ SK + + ++ +E+ + Q+ + +
Sbjct: 326 KLREFASHLQQLQDALNEL---------TEEHSKATQEWLEKQAQLEKELSAALQDKKCL 376
Query: 1315 ENKTLEMELKLKGLEELISTLKDTKGAQK--VINWHMKIEELRL---------------- 1356
E K ++ KL LEE +S L+D +K V+ +++E L+
Sbjct: 377 EEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARV 436
Query: 1357 ---------QELKLNRELVKDKEEIKYLNNIISEYERTISSL---EEEIVQQNKFHEERQ 1404
QE KL E +EE + L+++I++ + +IS+L +EE+ Q ++ H R
Sbjct: 437 EMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARL 496
Query: 1405 MAW------------------DQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPS 1446
A DQ L++Q +Q ++ Q+ E+A+ +
Sbjct: 497 TAQVASLTSELTTLNATIQQQDQELAGLKQQAK---EKQAQLAQTLQQQEQASQGLRHQV 553
Query: 1447 LPLPNQLEIALRKIKENIRIILETR----------------------ATCKSLEEKLKEK 1484
L + L+ +++KE TR A K LE KEK
Sbjct: 554 EQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEK 613
Query: 1485 ESALRLAEQNILSRDKVINELRLRLPAT---AEREKLIAELGRKEMEPKSHHTLKIAHQT 1541
+ L + +Q + +V NE R + A+REK AEL RK E ++ ++ A Q
Sbjct: 614 AAKLEILQQQL----QVANEARDSAQTSVTQAQREK--AELSRKVEELQA--CVETARQE 665
Query: 1542 IANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHE--EDLHILHHRLELQADSSLNKF 1599
QA++ + E L+ Q +KA E++R +K + E L L L++ SL +
Sbjct: 666 QHEAQAQVAELELQLRSEQ---QKATEKERVAQEKDQLQEQLQALKESLKV-TKGSLEEE 721
Query: 1600 KQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITE 1659
K+ A D ++ E ++ ++E SL+ + K+ ++LE +R
Sbjct: 722 KRRAADALE----------------EQQRCISELKAETRSLVEQHKRERKELEEERAGR- 764
Query: 1660 LKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAP 1719
K E QL E H+ E + ++ E+ + ++ E + L E+ A +E +
Sbjct: 765 ---KGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ 821
Query: 1720 TTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQI 1779
+ + + LKE+ +KA R E+ A +E++ S E ++ QQ
Sbjct: 822 QEEAQYGAMFQEQLMTLKEECEKA--------RQELQEA-KEKVAGIESHSELQISRQQ- 871
Query: 1780 VDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILRE 1839
++ +L+ NL + + ++ + R L D+L+ L ++ K ++
Sbjct: 872 ---------NELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETL 922
Query: 1840 KEEIDQENDELKRQIKRLTSGL-----------QGKPLTDNKQSLIEELQRKVKKLENQL 1888
+ ++ + R++ + + QG+ Q+ ++ ++R+ +++ N+L
Sbjct: 923 VRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCST-QAALQAMEREAEQMGNEL 981
Query: 1889 E---GKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLN- 1944
E + E + +E+ +E + ++ +A+ + K E E+ L LN
Sbjct: 982 ERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEM-RLQNALNE 1040
Query: 1945 ------TLKDLFAKADKEKLTLQRKL-KTTGMTVDQVLGIRALESEKELEELKKRNLDLE 1997
TL++ A A EK ++L K G+ Q+ KELEEL++ L+
Sbjct: 1041 QRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQI---------KELEELRQTVKQLK 1091
Query: 1998 NDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQR 2057
+ A + E + KL AL + SK + E D +R
Sbjct: 1092 EQLAKKEKEHASGSGAQSEAAG-RTEPTGPKLEALRAEVSK--LEQQCQKQQEQADSLER 1148
Query: 2058 EQELQKENLKLSSENIE-LKFQLEQANKDLPRLKNQVRDL-KEMCEFLKK----EKAEVQ 2111
E ++ + +E L+ QLE+ ++L ++ + +E+ F K KAE +
Sbjct: 1149 SLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE 1208
Query: 2112 RKLGHVRG---SGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQ 2168
K RG + R I LE+ + ++ + V + + E+++LK+ + SEK +E+
Sbjct: 1209 WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLV-MAESEKSQKLEE 1267
Query: 2169 ENEKLKAELEKLKAHLGHQLSM---HYESKTKGTEKIIAENERLRKELKKETDAAEKLRI 2225
L+AE A + S +S + EK +E LR+EL + + AE+L
Sbjct: 1268 RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELG- 1326
Query: 2226 AKNNLEILNEKM--------TVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYET 2277
L+ EK T+QLE T + +E P + + +
Sbjct: 1327 --QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELL-PAKHLCQQLQAEQAAAEKRHRE 1383
Query: 2278 KLKE-------LETDIAKKNQSITDLKQLVKEATERE---QKVNKYNEDLEQQIKILKHV 2327
+L++ L ++ + + + +L L ++ E+E Q++ +Q+ +LK
Sbjct: 1384 ELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKA 1443
Query: 2328 PEG--AETEQGLKRELQVLR-LANHQLDKEKAELIHQIEANKD---------QSGAESTI 2375
G AE +GL + R +LD+ + + + ++ A + Q A+ST
Sbjct: 1444 -HGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTA 1502
Query: 2376 PDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLK---KELENFDPSFFEEIEDLKYNYK 2432
+ + + K + + ++ E+Q +EE +KL ++LE F +++E+L
Sbjct: 1503 RELEVMTAKYEGAKVKVLE---ERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLA 1559
Query: 2433 EEVKKNILLEEKVKKLSEQLG 2453
+ + + + ++K+K + Q G
Sbjct: 1560 DSDQASKVQQQKLKAVQAQGG 1580
Score = 117 bits (293), Expect = 1e-25
Identities = 261/1266 (20%), Positives = 498/1266 (39%), Gaps = 235/1266 (18%)
Query: 1293 LQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIE 1352
LQ + ++ + K E N + E+EL+L +L+ T KD + A +I+
Sbjct: 209 LQTPQFQMRRLKKQLADERSNRD----ELELELAENRKLL-TEKDAQIAMM----QQRID 259
Query: 1353 ELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREV 1412
L L LN + E K L + + E L E + Q E+
Sbjct: 260 RLAL----LNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQ------- 308
Query: 1413 DLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRA 1472
++R+++ + ++ ++F QL+ AL ++ E ++A
Sbjct: 309 -MDRKINQLSEENGDLSFKLREFASHL-----------QQLQDALNELTEE-----HSKA 351
Query: 1473 TCKSLEEKLK-EKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKS 1531
T + LE++ + EKE + L ++ L I + +L ++ E+ +++L + K
Sbjct: 352 TQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKL-----SQLEEHLSQLQDNPPQEKG 406
Query: 1532 H--------HTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKK-HEEDLH 1582
TLK T+A +L + E+L+ E+ ++E + + ++ H E+
Sbjct: 407 EVLGDVLQLETLKQEAATLAANNTQLQARVEMLET-----ERGQQEAKLLAERGHFEEEK 461
Query: 1583 ILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLV 1642
L SS++ Q +L + S H RL Q SL+S L
Sbjct: 462 QQLSSLITDLQSSISNLSQAKEELEQASQA------HGARLTA-------QVASLTSELT 508
Query: 1643 KLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQ 1702
L Q +++ + + KE + Q + E + ++ +VE L L Q +++ +
Sbjct: 509 TLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLK 568
Query: 1703 CLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEER 1762
E+ ++EA + + E ++ L ++ K L E A++ ++
Sbjct: 569 ----EVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQL 624
Query: 1763 IISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDL 1822
++ ++ A +V Q R EL +VE+L + ++T++ ++ + +L
Sbjct: 625 QVANEARDSAQTSVTQ-AQREKAELSRKVEEL-------QACVETARQEQHEAQAQVAEL 676
Query: 1823 NNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKP--LTDNKQ---SLIEEL 1877
+L+ +Q+ EKE + QE D+L+ Q++ L L+ L + K+ +EE
Sbjct: 677 ELQLRSEQQKAT----EKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQ 732
Query: 1878 QRKVKKLENQLEGKVEEV--DLKPMKEKNAKEELIR---WEEGKKWQAKIEGIRNKLKEK 1932
QR + +L+ + VE+ + K ++E+ A + + + G+ QA+ E +R +L E
Sbjct: 733 QRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEA 792
Query: 1933 EGEVFTLTKQLNTL-KDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKK 1991
T + L K++ A ++ + + Q + + M +Q++ ++ E EK +E
Sbjct: 793 MAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKE-ECEKARQE--- 848
Query: 1992 RNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIES 2051
LQE +K ++GIES
Sbjct: 849 ---------------------------------LQE--------------AKEKVAGIES 861
Query: 2052 DDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQ 2111
E ++ ++ +L+ + L L+Q + R + DL + E + EV
Sbjct: 862 HS----ELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVA 917
Query: 2112 RKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASG---ILTSEKMANIEQ 2168
R VR +G +T L+K+ R+ E L++ G T + +E+
Sbjct: 918 RLETLVRKAGEQQETASR-----ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMER 972
Query: 2169 ENEKLKAELEKLKAHLGHQLSMHYESK---TKGTEKIIAENERLRKELKKETDAAEKLRI 2225
E E++ ELE+L+A L E + + ++ E R + +L E A +L +
Sbjct: 973 EAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEM 1032
Query: 2226 AKNNLEILNEKM----TVQ-------LEETGKRLQFAESRGPQLEGADSKSWKSIVVTRM 2274
N LNE+ T+Q E+ GK + A+ RG LE A K + + T
Sbjct: 1033 RLQNA--LNEQRVEFATLQEALAHALTEKEGKDQELAKLRG--LEAAQIKELEELRQT-- 1086
Query: 2275 YETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQI-KILKHVPEGAET 2333
+K+L+ +AKK + EA R + E L ++ K+ + + E
Sbjct: 1087 ----VKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQ 1142
Query: 2334 EQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSG-AESTIPDADQ----LKEKIKD- 2387
L+R L+ R + + D L Q+E + G ++S + A + + K++D
Sbjct: 1143 ADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDH 1202
Query: 2388 ------LETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFE---EIEDLKYNYKEEVKKN 2438
+ Q+ E + I L++E+ + E E ++LK E +K+
Sbjct: 1203 SKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKS 1262
Query: 2439 ILLEEKVKKL-----------------------------------SEQLGVELTSPVAAS 2463
LEE+++ L SE L ELTS +
Sbjct: 1263 QKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERA 1322
Query: 2464 EEFEDE 2469
EE E
Sbjct: 1323 EELGQE 1328
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 173 bits (438), Expect = 2e-42
Identities = 249/1212 (20%), Positives = 536/1212 (44%), Gaps = 150/1212 (12%)
Query: 1244 EKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQE 1303
+++Q L ++ RN A +L+ R F+ PL Q + + M+ + + +K+ +
Sbjct: 801 KRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVRE- 859
Query: 1304 MKNSQQEHRNMENKTLEMELKLKGLE--ELISTLKDTKGAQKVINWHMKIEELRLQEL-- 1359
K E+R E +TL+ +L + L+ E + + + + + ++ L+E+
Sbjct: 860 -KQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICH 918
Query: 1360 KLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLD 1419
L + +++E ++L + ++ I LEE++ ++ ++ Q+ +V E +L
Sbjct: 919 DLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQL----EKVTTEAKLK 974
Query: 1420 IFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEE 1479
+ +Q + + K + + D L K K ++ + A LEE
Sbjct: 975 KLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEE 1034
Query: 1480 KLK-------EKESALRLAEQNILSRDKVINELR-----LRLPATAEREKLIAELGRKEM 1527
+L+ E E R E + I EL+ L++ + E+L A L R E
Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE 1094
Query: 1528 EPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHR 1587
E + +A + I +++++++ +E L+ + KA +++R++ E+L L
Sbjct: 1095 EAAQKN---MALKKIRELESQISELQEDLESERASRNKAEKQKRDL----GEELEALKTE 1147
Query: 1588 LELQADSS-----LNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLV 1642
LE DS+ L ++ +++K++ H ++ EM Q ++ + L+ L
Sbjct: 1148 LEDTLDSTAAQQELRSKREQEVNILKKT-LEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 1643 KLKKVSQDLERQREITELKVKEFEN---IKLQLQENHEDEVKKVKAEVEDLKYLLDQSQK 1699
+ K+V +LE+ ++ E + E N + LQ + + E + KKV+A++++L+ ++ ++
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266
Query: 1700 ESQCLK---SELQAQKE------ANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLE 1750
L ++LQ + + + S + ++ + L+SQL ++ + +R L
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326
Query: 1751 LRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKN 1810
L ++ +E+ S Q E + +++ L QV D+ + + L+T++
Sbjct: 1327 LSTKLKQVEDEKN-SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385
Query: 1811 RENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNK 1870
+ L +L L+ ++K AY+K+ + K + QE D+L + D++
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL-------------DHQ 1432
Query: 1871 QSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLK 1930
+ L++K KK + QL + + + K +E++ E R +E K + +
Sbjct: 1433 RQSACNLEKKQKKFD-QLLAEEKTISAKYAEERDRAEAEAREKETKA--LSLARALEEAM 1489
Query: 1931 EKEGEVFTLTKQLNT-LKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEEL 1989
E++ E+ L KQ T ++DL + D ++ K+ RALE +++EE+
Sbjct: 1490 EQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSK----------RALE--QQVEEM 1537
Query: 1990 KKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGI 2049
K + +LE+++ ED L+ L+ L A++ QF +D + S
Sbjct: 1538 KTQLEELEDEL------------QATEDAKLR---LEVNLQAMKAQFERDLQGRDEQSE- 1581
Query: 2050 ESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAE 2109
+++++L ++ ++ +E + + Q A +L+ ++DL+ + K + E
Sbjct: 1582 ------EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDE 1635
Query: 2110 VQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLK--KASGILTSEKMANIE 2167
++L ++ + + EL+ T ++++ + + ++LK +A I E++A E
Sbjct: 1636 AIKQLRKLQAQMKD--CMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAE 1693
Query: 2168 QENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAK 2227
+ + + E ++L + + S KG +A E+ R E + E+L +
Sbjct: 1694 RAKRQAQQERDELADEIAN-------SSGKGA---LALEEKRRLEARI-AQLEEELEEEQ 1742
Query: 2228 NNLEILNEKM---TVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELET 2284
N E++N+++ +Q+++ L S + E A + + + + KL+E+E
Sbjct: 1743 GNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQ---NKELKVKLQEMEG 1799
Query: 2285 DIAKKNQ-SITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQV 2343
+ K + SIT L+ + + E+ K + +Q++ TE+ LK L
Sbjct: 1800 TVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVR---------RTEKKLKDVLL- 1849
Query: 2344 LRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLK 2403
Q+D E+ E KDQ AD+ ++K L+ QL+ ++ E Q
Sbjct: 1850 ------QVDDER----RNAEQYKDQ---------ADKASTRLKQLKRQLEEAEEEAQRAN 1890
Query: 2404 EEIKKLKKELEN 2415
+KL++ELE+
Sbjct: 1891 ASRRKLQRELED 1902
Score = 148 bits (374), Expect = 6e-35
Identities = 250/1228 (20%), Positives = 509/1228 (41%), Gaps = 207/1228 (16%)
Query: 699 LHLKAQVDQLTGRNEELRQELRESRKEAIN--------YSQQLAKANLKIDHLEKETSLL 750
L + Q +++ + EEL ++RE + A N SQ +A+ + L+ ET L
Sbjct: 838 LQVSRQEEEMMAKEEEL-VKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 751 RQSEG--SNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDY 808
++E + + K +L + I + + + E HL E + ++ ++ LE+ LE+
Sbjct: 897 AEAEELRARLTAKKQELEE-ICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEE- 954
Query: 809 NRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNAL 868
++S K L EK T + + K ++EE+ LEDQ + A + K + +
Sbjct: 955 ---------EESARQKLQL-EKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEF 1004
Query: 869 QMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEV 928
+ E + E S+ + L+ +++I + E + R+E EK + +L ++
Sbjct: 1005 TTNLTEEE----EKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDL 1060
Query: 929 CEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQ 988
++I LQ ++A K+ +K + +L+ +E Q N K R++ ++ + +
Sbjct: 1061 SDQIAELQA--QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIREL---ESQISE 1115
Query: 989 RTSNLEHLECENISLKEQVESINKELEITKEKLH-TIEQ-AWEQETKLGNESSMDKAKKS 1046
+LE ++Q + +ELE K +L T++ A +QE + E ++ KK+
Sbjct: 1116 LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKT 1175
Query: 1047 ITNSDIVSISKKITMLEMKELNER------QRAEHCQKMYEHLRTSLKQMEERNFELETK 1100
+ + + + + EM++ + + ++ E +++ +L + + +E EL +
Sbjct: 1176 LEEE---AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE 1232
Query: 1101 FAELTKINLDAQ----KVEQML-------------RDELADSVSKAVSDADR-------- 1135
L + D++ KVE L R ELAD V+K + D
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS 1292
Query: 1136 -QRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQ-AQ 1193
+ +L K+ L+ ++ +E+ RQ L+ + + + E S R QL + + A+
Sbjct: 1293 DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAK 1352
Query: 1194 SDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYAR 1253
+ + IA LH ++ ++G LE+ +K++ L Q+ +EK A Y +
Sbjct: 1353 HNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAA--YDK 1410
Query: 1254 LEGRNRA--KHLRQTIQSLRRQFSGALPLAQ-QEKFSKTMIQLQNDKLKIMQEMKNSQQE 1310
LE + L + L Q A L + Q+KF + + + + K +E ++ E
Sbjct: 1411 LEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAE 1470
Query: 1311 HRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKE 1370
R E K L + + LEE + QK ++E L Q +L+ K+
Sbjct: 1471 AREKETKALSLA---RALEEAME--------QKA-----ELERLNKQFRTEMEDLMSSKD 1514
Query: 1371 EIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILN 1430
++ + E E++ +LE+++ EE + ++ E +L+ D R + +
Sbjct: 1515 DV---GKSVHELEKSKRALEQQV-------EEMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 1431 AAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETR----ATCKSLEEKLKEKES 1486
+FE + S QL +R+++ + + R A K LE LK+ E+
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624
Query: 1487 ALRLAEQNILSRDKVINELRLRLPAT------------AEREKLIAELGRKEMEPKSHHT 1534
+ A +N RD+ I +LR +L A A RE+++A+ E + KS
Sbjct: 1625 HIDSANKN---RDEAIKQLR-KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKS--- 1677
Query: 1535 LKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADS 1594
M+A + Q +E L +R +A++E+ E+ AD
Sbjct: 1678 ----------MEAEMIQLQEELAAAERAKRQAQQERDEL------------------ADE 1709
Query: 1595 SLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQ 1654
N + A L ++ R+A++E+ + E+ + + +LKK + +++
Sbjct: 1710 IANSSGKGALALEEKRRLEA-------RIAQLEEELEEEQGNTELINDRLKKANLQIDQI 1762
Query: 1655 REITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEA 1714
N L L+ +H + + + ++E + KE + E++ ++
Sbjct: 1763 ------------NTDLNLERSHAQKNENARQQLE-------RQNKELKVKLQEMEGTVKS 1803
Query: 1715 NSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHL 1774
+A T + + +L+ QL + K+++A + +
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRR------------------------ 1839
Query: 1775 NVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYN 1834
++ +++ QV+D N + K+ + R L L + E Q+ +
Sbjct: 1840 -----TEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRR 1894
Query: 1835 KILREKEEIDQENDELKRQIKRLTSGLQ 1862
K+ RE E+ + D + R++ L + L+
Sbjct: 1895 KLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 140 bits (354), Expect = 1e-32
Identities = 236/1198 (19%), Positives = 506/1198 (42%), Gaps = 141/1198 (11%)
Query: 962 LELANKQYNELTAKYRDILQ----KDNMLVQRTSNLEHLECENISLKEQVESINKELEIT 1017
L+L N Q+ L K + +LQ ++ M+ + ++ E + + E + ++
Sbjct: 820 LKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLM 879
Query: 1018 KEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQ 1077
EKL EQ + ET+L E+ +A+ + ++ I LE + E +R +H Q
Sbjct: 880 AEKLQLQEQL-QAETELCAEAEELRARLTAKKQELEEICHD---LEARVEEEEERCQHLQ 935
Query: 1078 KMYEHLRTSLKQMEERNFELETKFAEL------TKINLDAQKVEQMLRDELADSVSKAVS 1131
+ ++ +++++EE+ E E+ +L T+ L + EQ++ ++ ++K
Sbjct: 936 AEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKK 995
Query: 1132 DADRQRILELEKN---EMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLL 1188
+ RI E N E E ++KL+ + +E +++ + +E+E R +L
Sbjct: 996 LLE-DRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLE 1054
Query: 1189 DYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQA 1248
+D IA+L L++ + K ++++A R+E++ +K A
Sbjct: 1055 G--DSTDLSDQIAELQAQIAELKMQ----------LAKKEEELQAALARVEEEAAQKNMA 1102
Query: 1249 LYYARLEGRNRAKHLRQTIQSLRRQFSGA----LPLAQQEKFSKTMIQLQNDKLKIMQEM 1304
L R E ++ L++ ++S R + A L ++ + KT ++ D QE+
Sbjct: 1103 LKKIR-ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL 1161
Query: 1305 KNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRE 1364
++ +++ N+ KTLE E K T AQ I+E+R + + E
Sbjct: 1162 RSKREQEVNILKKTLEEEAK-------------THEAQ--------IQEMRQKHSQAVEE 1200
Query: 1365 LVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQ 1424
L + E+ K + + + ++T+ + E+ + K + + + + +E QL +
Sbjct: 1201 LAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVK 1260
Query: 1425 QNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEK 1484
NE E + D L +L+ + ++ + +LE +L++
Sbjct: 1261 FNE-------GERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDT 1313
Query: 1485 ESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIA--HQTI 1542
+ L+ + LS L +L + + E +E E K + +IA H +
Sbjct: 1314 QELLQEENRQKLS-------LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQV 1366
Query: 1543 ANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQT 1602
A+M+ ++ L+ + + K +++ + ++HEE + ++ +K ++T
Sbjct: 1367 ADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKV------------AAYDKLEKT 1414
Query: 1603 AWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKV 1662
L ++ + H + A + ++ LL + K +S +R+ E +
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSA---CNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEA 1471
Query: 1663 KEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQA---QKEANSRAP 1719
+E E L L E+ +++ KAE+E L ++ K ++ + E + RA
Sbjct: 1472 REKETKALSLARALEEAMEQ-KAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRA- 1529
Query: 1720 TTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTA--AAEERIISATSQKEAHLNVQ 1777
+ VE +K+QL E + +A A L L + A A ER + ++ Q
Sbjct: 1530 ---LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ 1586
Query: 1778 QIVDRHTRELKTQVEDLNENLL-------KLKEALKTSKNRENSLTDNLNDLNNELQKKQ 1830
+ R RE++ ++ED + KL+ LK + +S N ++ +L+K Q
Sbjct: 1587 LV--RQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ 1644
Query: 1831 KAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLEN-QLE 1889
+RE ++ +E+ Q K K L + +I+ LQ ++ E + +
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKE-----NEKKLKSMEAEMIQ-LQEELAAAERAKRQ 1698
Query: 1890 GKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDL 1949
+ E +L ++ + + EE ++ +A+I + +L+E++G + +L
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL------ 1752
Query: 1950 FAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQAL 2009
+K LQ T + +++ A ++E ++L+++N +L+ + M
Sbjct: 1753 ------KKANLQIDQINTDLNLERS---HAQKNENARQQLERQNKELKVKLQEMEGTVKS 1803
Query: 2010 PRDSVVEDLHLQNRYLQEKL--HALEKQFS----KDTYSKPSISGIESDDHCQREQELQK 2063
+ + L + L+E+L E+Q + + T K ++ DD + ++ +
Sbjct: 1804 KYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKD 1863
Query: 2064 ENLKLSSENIELKFQLEQANKDLPR-------LKNQVRDLKEMCEFLKKEKAEVQRKL 2114
+ K S+ +LK QLE+A ++ R L+ ++ D E + + +E + ++ KL
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 139 bits (350), Expect = 3e-32
Identities = 238/1120 (21%), Positives = 468/1120 (41%), Gaps = 192/1120 (17%)
Query: 161 KLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLD 220
++ R+ + + K E+L + +KQ+ ++ +R E +SQL + +L + L
Sbjct: 839 QVSRQEEEMMAKEEELVKV---REKQLAAE-----NRLTEMETLQSQLMAEKLQLQEQLQ 890
Query: 221 EIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYN--------RMKAIVHQTDNVID 272
L E++ + ++ LEE ++E +E K + + +
Sbjct: 891 AETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEE 950
Query: 273 QLKKENDHYQ-LQVQELTDLLKSKN-EEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQM 330
QL++E Q LQ++++T K K EE+ I+ N K+ + K +L +D I E+
Sbjct: 951 QLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLL---EDRIAEFTTN 1007
Query: 331 LHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKN 390
L EK K+ L K+ A+ ++ER + + +++E+ +++E ++ + D
Sbjct: 1008 LTEEEEKSKS--LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIA 1065
Query: 391 ELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKD 450
ELQ +Q +K+Q L +K +E + E +A +K+ ALK++++
Sbjct: 1066 ELQ--------AQIAELKMQ-----LAKKEEELQAALARVEEEAAQKNM----ALKKIRE 1108
Query: 451 YESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRE----- 505
ES + L++ + + +N+ + + R+ L +E+ L+ ++ D LD A +E
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRD---LGEELEALKTELEDTLDSTAAQQELRSKR 1165
Query: 506 --RVGLEPKTMID--LTEFRNSKHLKQQQYRAENQI-------------LLKEIESLEEE 548
V + KT+ + T + ++Q+ +A ++ L K ++LE E
Sbjct: 1166 EQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENE 1225
Query: 549 RLDLKKKIRQMAQERG----KRSATSGLTTEDLNLTENISQGDRISERKLDLLS-----L 599
R +L +++ + Q +G KR E L ++G+R+ D ++ L
Sbjct: 1226 RGELANEVKVLLQGKGDSEHKRKKVEAQLQE---LQVKFNEGERVRTELADKVTKLQVEL 1282
Query: 600 KN----MSEAQSKNEFLSRELIEKERDLERSRTVIAK-------FQNKLKELVEENKQLE 648
N +S++ SK+ L+++ E L+ ++ ++ + KLK++ +E
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFR 1342
Query: 649 EGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIES---------KNAEGIFDASL 699
E ++E +A ++K + + + +E V +E+ K+ EG+
Sbjct: 1343 EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE 1402
Query: 700 HLKAQVDQLTGRNEELRQELRESRKEAINYSQ---QLAKANLKIDHL------------- 743
A D+L L+QEL + + + Q L K K D L
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE 1462
Query: 744 ----------EKETSLL-------------RQSEGSNVVFKG-----IDLPDGIAPSSAS 775
EKET L + E N F+ + D + S
Sbjct: 1463 ERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522
Query: 776 IINSQNEYLIHLLQELENKEKKLKNLEDSL---EDYNRKFAVIRHQQSLLYKEYLSEKET 832
+ S+ L Q++E + +L+ LED L ED + V ++ L ++
Sbjct: 1523 LEKSKRA----LEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDE 1578
Query: 833 WKTESK-----TIKEEKRKLEDQVQQDAIKVKEYNNL---LNALQMDSDEMKKILAENSR 884
E K ++E + +LED+ +Q ++ V L L L+ D K E +
Sbjct: 1579 QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK 1638
Query: 885 KITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVC---EKIGCLQRFKEM 941
++ LQ K +R+ ++ + ++ + +L SMEAE+ E++ +R K
Sbjct: 1639 QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQ 1698
Query: 942 AIFKIAALQKVVDNSVSLSELELANKQYNEL---------------TAKYRDILQKDNML 986
A + L + NS L L K+ E T D L+K N+
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ 1758
Query: 987 VQRTS---NLEHLECE-NISLKEQVESINKELEITKEKLH-TIEQAWEQ-----ETKLGN 1036
+ + + NLE + N + ++Q+E NKEL++ +++ T++ ++ E K+
Sbjct: 1759 IDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQ 1818
Query: 1037 -ESSMDKAKK--SITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEER 1093
E +D K + KK+ + ++ +ER+ AE + + T LKQ++
Sbjct: 1819 LEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKR- 1877
Query: 1094 NFELETKFAELTKINLDAQKVEQMLRD--ELADSVSKAVS 1131
+LE E + N +K+++ L D E AD++++ VS
Sbjct: 1878 --QLEEAEEEAQRANASRRKLQRELEDATETADAMNREVS 1915
Score = 133 bits (334), Expect = 2e-30
Identities = 213/971 (21%), Positives = 427/971 (43%), Gaps = 144/971 (14%)
Query: 1543 ANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQT 1602
A ++ R Q + K + LL+ +R+E+ E++ K EE + + +L A++ L + +
Sbjct: 818 AYLKLRNWQWWRLFTKVKPLLQVSRQEE-EMMAKEEELVKV--REKQLAAENRLTEMETL 874
Query: 1603 AWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKV 1662
LM + ++L E Q E L +L Q+LE E +V
Sbjct: 875 QSQLMAEK----------LQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARV 924
Query: 1663 KEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTT 1722
+E E LQ E KK++ +++L+ L++ + Q +LQ +K TT
Sbjct: 925 EEEEERCQHLQA----EKKKMQQNIQELEEQLEEEESARQ----KLQLEK-------VTT 969
Query: 1723 MRNLVERLKSQLALKEKQQK-ALSRALLELR-AEMTA---AAEERIISATSQKEAHLNVQ 1777
L + + Q+ L+++ K A + LLE R AE T EE+ S K H +
Sbjct: 970 EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI 1029
Query: 1778 QIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKIL 1837
++ R + Q ++L + KL+ ++ L + +L +L KK++ L
Sbjct: 1030 TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAAL 1089
Query: 1838 -REKEEIDQENDELKR------QIKRLTSGLQGKPLTDNK-----QSLIEELQRKVKKLE 1885
R +EE Q+N LK+ QI L L+ + + NK + L EEL+ +LE
Sbjct: 1090 ARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELE 1149
Query: 1886 NQLEGKVEEVDLKPMKEK--NAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQL 1943
+ L+ + +L+ +E+ N ++ + EE K +A+I+ +R K + E L +QL
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLE-EEAKTHEAQIQEMRQKHSQAVEE---LAEQL 1205
Query: 1944 NTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYM 2003
K + A +K K TL+ + G ++V + L K E K++ ++ + L +
Sbjct: 1206 EQTKRVKANLEKAKQTLENE---RGELANEV---KVLLQGKGDSEHKRKKVEAQLQELQV 1259
Query: 2004 RAHQA-LPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQ 2062
+ ++ R + + + L L + SK + S +ES Q QEL
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQ--LQDTQELL 1317
Query: 2063 KENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGR 2122
+E + + + L +L+Q + + Q+ + +E L+K+ A + ++ ++
Sbjct: 1318 QEE---NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK---- 1370
Query: 2123 SGKTIPELEKTIGLMK---KVVEKVQRENEQLKKASGILTSEKMA---NIEQENEKLKAE 2176
++E ++G ++ +V K+Q++ E L + EK+A +E+ +L+ E
Sbjct: 1371 -----KKMEDSVGCLETAEEVKRKLQKDLEGLSQRH----EEKVAAYDKLEKTKTRLQQE 1421
Query: 2177 LEKLKAHLGHQL--SMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILN 2234
L+ L L HQ + + E K K ++++AE + + + +E D AE
Sbjct: 1422 LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEA---------R 1472
Query: 2235 EKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSIT 2294
EK T L + L+ A + +LE + + + T++++L + +S+
Sbjct: 1473 EKETKALS-LARALEEAMEQKAELER----------LNKQFRTEMEDLMSSKDDVGKSVH 1521
Query: 2295 DLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETE----QGLKRELQV------- 2343
+L+ K LEQQ++ +K E E E + K L+V
Sbjct: 1522 ELE--------------KSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKA 1567
Query: 2344 -----LRLANHQLDKEKAELIHQI-----EANKDQSGAESTIPDADQLKEKIKDLETQLK 2393
L+ + Q +++K +L+ Q+ E ++ + +L+ +KDLE +
Sbjct: 1568 QFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHID 1627
Query: 2394 MSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLG 2453
++ + ++++KL+ ++++ E++D + + +E + + E+K+K + ++
Sbjct: 1628 SANKNRDEAIKQLRKLQAQMKD----CMRELDDTRASREEILAQAKENEKKLKSMEAEM- 1682
Query: 2454 VELTSPVAASE 2464
++L +AA+E
Sbjct: 1683 IQLQEELAAAE 1693
Score = 128 bits (321), Expect = 8e-29
Identities = 219/1111 (19%), Positives = 456/1111 (41%), Gaps = 120/1111 (10%)
Query: 1 MPPNINWKEIMKVDPDDLPRQEELADNLLISLSKVEVN----ELKSEKQENVIHLFRITQ 56
M + +E ++ + + EEL L ++E E + E++E + +
Sbjct: 879 MAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEK 938
Query: 57 SLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMA--QQSAGGRDTRFLR 114
M+ QE+E LEE E A ++ + + K+ KLE E + Q ++ + L
Sbjct: 939 KKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE 998
Query: 115 NEICQLEKQLEQKDRE--------------LEDMEKELEKEKKVNEQLALRNEEAENENS 160
+ I + L +++ + + D+E+ L +E+K + +E E
Sbjct: 999 DRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEK-------QRQELEKTRR 1051
Query: 161 KLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETL---LSRRGEDSDYRSQLSKKNYELIQ 217
KL ++ L + +L I + + Q+ ++E L L+R E++ ++ KK EL
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111
Query: 218 YLDEIQTLTE----ANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQ 273
+ E+Q E + K E Q +++ + LE E+E D + + + + ++
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171
Query: 274 LKK----ENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQ 329
LKK E ++ Q+QE+ EE + ++E+ K + ++ + + +Q
Sbjct: 1172 LKKTLEEEAKTHEAQIQEMRQKHSQAVEE-------LAEQLEQTKRVKANLE----KAKQ 1220
Query: 330 MLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCI----- 384
L N R +L N V L QG + + + K + Q+++ + + +
Sbjct: 1221 TLENERGELAN--------EVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELA 1272
Query: 385 --IEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELV 442
+ L+ EL G + S K+ L+ + ++ T EL + + R+K +
Sbjct: 1273 DKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQD---TQELLQEENRQK----L 1325
Query: 443 EALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEA 502
+LK E + + E + K+ + +++I L ++ ++ K+ D + E
Sbjct: 1326 SLSTKLKQVEDEKNSFREQLEEEEEAKHNL---EKQIATLHAQVADMKKKMEDSVGCLET 1382
Query: 503 LRERVGLEPKTMIDLTEFRNSK-----HLKQQQYRAENQI--LLKEIESLEEERLDLKKK 555
E K + L++ K L++ + R + ++ LL +++ + +L+KK
Sbjct: 1383 AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442
Query: 556 IRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLL-SLKNMSEAQSKNEFLSR 614
++ Q + S E+ + E ++ + L L +L+ E +++ E L++
Sbjct: 1443 QKKFDQLLAEEKTISAKYAEERDRAE--AEAREKETKALSLARALEEAMEQKAELERLNK 1500
Query: 615 ELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIK-EMQKDPDVKGGETS 673
+ + DL S+ + K ++L++ +Q E MK L+ ++ E+Q D K
Sbjct: 1501 QFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAK----- 1555
Query: 674 LIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQL 733
LE + A++++ + + + QL + E+ EL + RK+
Sbjct: 1556 ---LRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ--RSMAVA 1610
Query: 734 AKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELEN 793
A+ L++D + E + ++ + K + ++ +L + +
Sbjct: 1611 ARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKE 1670
Query: 794 KEKKLKNLEDSLEDYNRKFAV---IRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQ 850
EKKLK++E + + A + Q E E + EEKR+LE +
Sbjct: 1671 NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR 1730
Query: 851 VQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVN-EKSLIRQYTTLVELER- 908
+ Q +++E ++ +D +KK + + Q+N + +L R + E R
Sbjct: 1731 IAQLEEELEEEQ---GNTELINDRLKK------ANLQIDQINTDLNLERSHAQKNENARQ 1781
Query: 909 QLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQ 968
QL ++N++ K +L ME V K E KIA L++ +DN E + A KQ
Sbjct: 1782 QLERQNKELKVKLQEMEGTVKSKYKASITALEA---KIAQLEEQLDNET--KERQAACKQ 1836
Query: 969 YNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAW 1028
K +D+L + + N E + + +++ + ++LE +E+ ++A
Sbjct: 1837 VRRTEKKLKDVLLQ---VDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEE---AQRAN 1890
Query: 1029 EQETKLGNESSMDKAKKSITNSDIVSISKKI 1059
KL E N ++ S+ K+
Sbjct: 1891 ASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 110 bits (275), Expect = 2e-23
Identities = 155/689 (22%), Positives = 297/689 (43%), Gaps = 86/689 (12%)
Query: 1796 ENLLKLKEALKTSKNRENSLTDNLNDLNNE---LQKKQKAYNKILREKEEIDQENDELKR 1852
E L+K++E ++NR + + L E LQ++ +A ++ E EE+ K+
Sbjct: 852 EELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQ 911
Query: 1853 QIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRW 1912
+++ + L+ + + ++ + LQ + KK++ ++ E+++ +E++A+++L
Sbjct: 912 ELEEICHDLEAR--VEEEEERCQHLQAEKKKMQQNIQELEEQLE----EEESARQKLQL- 964
Query: 1913 EEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAK------ADKEKLTLQRKLKT 1966
E +AK++ + + E + L K+ L+D A+ ++EK KLK
Sbjct: 965 -EKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKN 1023
Query: 1967 TGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQ 2026
+ L R EK+ +EL+K LE D DL Q LQ
Sbjct: 1024 KHEAMITDLEERLRREEKQRQELEKTRRKLEGDST---------------DLSDQIAELQ 1068
Query: 2027 EKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDL 2086
++ L+ Q +K + ++ Q+ L+K +L S+ EL+ LE
Sbjct: 1069 AQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIR-ELESQISELQEDLESERASR 1127
Query: 2087 PRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQR 2146
+ + Q RDL E E LK E + + + + + E+ + ++KK +E+ +
Sbjct: 1128 NKAEKQKRDLGEELEALKTELEDT------LDSTAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 2147 ENE---QLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKII 2203
+E Q + E++A ++ +++KA LEK K L
Sbjct: 1182 THEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL------------------- 1222
Query: 2204 AENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADS 2263
ENER EL E L K + E +K+ QL+E +++F E + E AD
Sbjct: 1223 -ENER--GELANEVKV---LLQGKGDSEHKRKKVEAQLQEL--QVKFNEGERVRTELAD- 1273
Query: 2264 KSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKI 2323
K K V L + ++ +K + + L+ +++ E Q+ N+ L ++K
Sbjct: 1274 KVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQ 1333
Query: 2324 LKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQI-EANKDQSGAESTIPDADQLK 2382
++ + + + +L+ A H L+K+ A L Q+ + K + + A+++K
Sbjct: 1334 VE------DEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK 1387
Query: 2383 EKI-KDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILL 2441
K+ KDLE L EK ++++K K L+ +E++DL + + + L
Sbjct: 1388 RKLQKDLEG-LSQRHEEKVAAYDKLEKTKTRLQ-------QELDDLLVDLDHQRQSACNL 1439
Query: 2442 EEKVKKLSEQLGVELTSPVAASEEFEDEE 2470
E+K KK + L E T +EE + E
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAE 1468
Score = 97.1 bits (240), Expect = 2e-19
Identities = 176/899 (19%), Positives = 376/899 (41%), Gaps = 125/899 (13%)
Query: 1617 NKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDL-------ERQREITELKVKEFENIK 1669
+K F R + E+D ++ +++ + + +RQ+++T +KV
Sbjct: 759 SKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKV------- 811
Query: 1670 LQLQENHEDEVKKVKAE----VEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRN 1725
LQ N +K + +K LL S++E + + E + K +
Sbjct: 812 --LQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLT 869
Query: 1726 LVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTR 1785
+E L+SQL ++ Q + +A EL AE AEE T++K+ + ++
Sbjct: 870 EMETLQSQLMAEKLQLQEQLQAETELCAE----AEELRARLTAKKQELEEICHDLEARVE 925
Query: 1786 E-------LKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILR 1838
E L+ + + + +N+ +L+E L+ ++ L L + E + K+ +I+
Sbjct: 926 EEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKL--QLEKVTTEAKLKKLEEEQIIL 983
Query: 1839 EKE--EIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVD 1896
E + ++ +E L+ +I T+ L + EE + + KL+N+ E + +++
Sbjct: 984 EDQNCKLAKEKKLLEDRIAEFTTNLTEE----------EEKSKSLAKLKNKHEAMITDLE 1033
Query: 1897 LKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKE 1956
+ +E+ ++EL +K + K+EG L ++ E L Q+ LK AK ++E
Sbjct: 1034 ERLRREEKQRQEL------EKTRRKLEGDSTDLSDQIAE---LQAQIAELKMQLAKKEEE 1084
Query: 1957 KLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVE 2016
+++ + L K++ EL+ + +L+ D+ RA +
Sbjct: 1085 LQAALARVEEEAAQKNMAL--------KKIRELESQISELQEDLESERASR--------N 1128
Query: 2017 DLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQ--KENLKLSSENIE 2074
Q R L E+L AL+ + +DT + + + +REQE+ K+ L+ ++ E
Sbjct: 1129 KAEKQKRDLGEELEALKTEL-EDTLDS---TAAQQELRSKREQEVNILKKTLEEEAKTHE 1184
Query: 2075 LKFQ---------LEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHV-RGSGRSG 2124
+ Q +E+ + L + K +L++ + L+ E+ E+ ++ + +G G S
Sbjct: 1185 AQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE 1244
Query: 2125 KTIPELEKTIGLMK-----------KVVEKVQRENEQLKKASGILTSE--KMANIEQENE 2171
++E + ++ ++ +KV + +L +G+L+ K + + ++
Sbjct: 1245 HKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFS 1304
Query: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLE 2231
L+++L+ + L + TK +++ E R++L++E +A L L
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTK-LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH 1363
Query: 2232 ILNEKMTVQLEETGKRLQFAES----RGPQLEGADSKSWKSIVVTRMYETKLKELETDIA 2287
M ++E++ L+ AE LEG + + + E L+ ++
Sbjct: 1364 AQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL- 1422
Query: 2288 KKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLA 2347
+ + DL + A E+K K+++ L ++ I E + + RE + L+
Sbjct: 1423 --DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS 1480
Query: 2348 NHQLDKEKAELIHQIEA-NKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEI 2406
+ +E E ++E NK Q + +++DL + D+ K E+
Sbjct: 1481 LARALEEAMEQKAELERLNK-------------QFRTEMEDLMSS--KDDVGKS--VHEL 1523
Query: 2407 KKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEE 2465
+K K+ LE ++E+L+ + + LE ++ + Q +L SEE
Sbjct: 1524 EKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE 1582
Score = 78.2 bits (191), Expect = 9e-14
Identities = 92/451 (20%), Positives = 193/451 (42%), Gaps = 66/451 (14%)
Query: 34 KVEVNELKSEKQE--NVIHLFRITQSLMKMKAQEVELALEEVEKA--GEEQAKFENQLKT 89
+ E+ +L S K + +H ++ ++ + +E++ LEE+E E AK ++
Sbjct: 1503 RTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNL 1562
Query: 90 KVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNE--- 146
+ MK + E ++ GRD Q E++ +Q R++ +ME ELE E+K
Sbjct: 1563 QAMKAQFERDLQ-----GRDE--------QSEEKKKQLVRQVREMEAELEDERKQRSMAV 1609
Query: 147 ------QLALRNEEAENENSKLRREN--KRLKKKNEQLCQDIIDYQKQIDSQKETLLSRR 198
++ L++ EA +++ R+ K+L+K Q+ D +++D + +
Sbjct: 1610 AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMK----DCMRELDDTRASREEIL 1665
Query: 199 GEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYN 258
+ + +L E+IQ +E+ A + + + E+ + S + +E
Sbjct: 1666 AQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKR 1725
Query: 259 RMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNA------KVEE 312
R++A + Q + ++L++E + +L + D LK N + D I +N K E
Sbjct: 1726 RLEARIAQLE---EELEEEQGNTEL----INDRLKKANLQIDQINTDLNLERSHAQKNEN 1778
Query: 313 WKLILSSKDDEI-IEYQQMLHNLREKLKNA-------------QLDADKSNVMALQQGIQ 358
+ L ++ E+ ++ Q+M ++ K K + QLD + A + ++
Sbjct: 1779 ARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVR 1838
Query: 359 ERDSQIKMLTEQV-------EQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411
+ ++K + QV EQY + +K + ++ LK +L+ + + + + K+Q
Sbjct: 1839 RTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQR 1898
Query: 412 TLDILKEKTKEAERTAELAEADAREKDKELV 442
L+ E R + R D V
Sbjct: 1899 ELEDATETADAMNREVSSLKNKLRRGDLPFV 1929
Score = 40.8 bits (94), Expect = 0.017
Identities = 36/187 (19%), Positives = 89/187 (47%), Gaps = 22/187 (11%)
Query: 27 NLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFE-- 84
NL I ++N +S Q+N + +++ Q EL ++ E G ++K++
Sbjct: 1756 NLQIDQINTDLNLERSHAQKN-------ENARQQLERQNKELKVKLQEMEGTVKSKYKAS 1808
Query: 85 -NQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKK 143
L+ K+ +LE +L+ + R C KQ+ + +++L+D+ +++ E++
Sbjct: 1809 ITALEAKIAQLEEQLDNETKE---------RQAAC---KQVRRTEKKLKDVLLQVDDERR 1856
Query: 144 VNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSD 203
EQ + ++A +L+R+ + +++ ++ Q++++ ET + E S
Sbjct: 1857 NAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSS 1916
Query: 204 YRSQLSK 210
+++L +
Sbjct: 1917 LKNKLRR 1923
Score = 32.0 bits (71), Expect = 7.8
Identities = 46/186 (24%), Positives = 85/186 (45%), Gaps = 28/186 (15%)
Query: 2287 AKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRL 2346
AK+ Q +T +K L + + N L ++K L V + E+ + +E +++++
Sbjct: 800 AKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSR--QEEEMMAKEEELVKV 857
Query: 2347 ANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEI 2406
QL E + ++E + Q AE QL+E+++ ET+L E + L+ +
Sbjct: 858 REKQLAAENR--LTEMETLQSQLMAEKL-----QLQEQLQ-AETELCA---EAEELRARL 906
Query: 2407 KKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEF 2466
K+ELE E DL+ +EE ++ L+ + KK+ + + EE
Sbjct: 907 TAKKQELE-------EICHDLEARVEEEEERCQHLQAEKKKMQQN--------IQELEEQ 951
Query: 2467 EDEEES 2472
+EEES
Sbjct: 952 LEEEES 957
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 172 bits (436), Expect = 4e-42
Identities = 245/1212 (20%), Positives = 513/1212 (42%), Gaps = 133/1212 (10%)
Query: 1244 EKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQE 1303
+++Q L ++ RN A +L+ R F+ PL Q + + M +++ K +
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867
Query: 1304 MKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQEL--KL 1361
+ ++ E + +E K ++ + L+E + + + + + ++ L+E+ ++
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927
Query: 1362 NRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREV---DLERQL 1418
L ++++ + L + + + LEE++ ++ ++ Q+ E LE ++
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 987
Query: 1419 DIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIA--LRKIK-ENIRIILETRATCK 1475
+ D Q N++ + EE I D + L + E A L K+K ++ +I E K
Sbjct: 988 LVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044
Query: 1476 SLEEKLKEKESALRLAEQNILSRDKVINELR-----LRLPATAEREKLIAELGRKEMEPK 1530
E+ +E E R E + + I +L+ L++ + E+L A L R + E
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1104
Query: 1531 SHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 1590
+ A + I ++ ++ +E L + KA +++R++ E+L L LE
Sbjct: 1105 QKNN---ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL----GEELEALKTELED 1157
Query: 1591 QADSSLN----KFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKK 1646
DS+ + K+ + + T H ++ EM Q A+ + L+ L + K+
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 1647 VSQDLERQREITELKVKEFE---NIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQC 1703
+L++ ++ E + + + Q ++ E + KK++A+V++L+ ++
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 1704 LKSELQAQKEANSRAPTTTMRNLVE-----------RLKSQLALKEKQQKALSRALLELR 1752
L ++ K N T M N E L SQL ++ + +R L +
Sbjct: 1278 LNDKV--HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335
Query: 1753 AEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRE 1812
++ EER S Q + + +Q ++RH L Q+ D + L ++ + +
Sbjct: 1336 TKLRQLEEER-NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1394
Query: 1813 NSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQS 1872
+ +L + ++K AY+K+ + K + QE D+L + DN++
Sbjct: 1395 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL-------------DNQRQ 1441
Query: 1873 LIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEK 1932
L+ L++K +K + QL + + + K E++ E R E+ K + + L+ K
Sbjct: 1442 LVSNLEKKQRKFD-QLLAEEKNISSKYADERDRAEAEAR-EKETKALSLARALEEALEAK 1499
Query: 1933 EGEVFTLTKQLNT-LKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKK 1991
E E+ K L ++DL + D + K+ + L + E + +LEEL+
Sbjct: 1500 E-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS-----KRALETQMEEMKTQLEELED 1553
Query: 1992 RNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIES 2051
E+ L + + + DL ++ +EK L++Q + E+
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE----------YET 1603
Query: 2052 DDHCQREQE----LQKENLKLSSENIELKFQ-----LEQANKDLPRLKNQVRDLKEMCEF 2102
+ +R+Q K+ L+ +++EL+ E+A K L +L+ Q++D + E
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 2103 LKKEKAEVQRKLGHVRGSGRSGKT-IPELEKTIGLMKKVVEKVQRENEQLKKASGILTSE 2161
+ + E+ +S + + +L++ + ++ ++ E E+L + S
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 2162 KMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAE 2221
+ A ++ E +L+A + +L+ L + + E+ + K + E+L EL E A+
Sbjct: 1724 RNA-LQDEKRRLEARIAQLEEELEEEQG-NMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 2222 KLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKE 2281
K A+ LE N+++ +L E +EGA +KS + E K+ +
Sbjct: 1782 KNESARQQLERQNKELRSKLHE--------------MEGAVKSKFKSTIAA--LEAKIAQ 1825
Query: 2282 LETDI---AKKNQSIT--------DLKQLVKEATEREQKVNKYNEDLEQ---QIKILKHV 2327
LE + A++ Q+ T LK+++ + + + +Y E E+ ++K LK
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 2328 PEGAETE--------QGLKRELQVLRLANHQLDKEKAELIHQIEANKD-------QSGAE 2372
E AE E + L+REL +N + +E L ++ + +SG
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGR 1945
Query: 2373 STIPDADQLKEK 2384
I +AD +E+
Sbjct: 1946 RVIENADGSEEE 1957
Score = 171 bits (433), Expect = 8e-42
Identities = 270/1241 (21%), Positives = 525/1241 (42%), Gaps = 176/1241 (14%)
Query: 701 LKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVF 760
++A+ D+L E ++ E ++ +SQ + NL + L+ ET L ++E V
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR- 912
Query: 761 KGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQS 820
+ ++ + L +L E+E + ++ ++ L+ +K A QQ
Sbjct: 913 ----------------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA----QQM 952
Query: 821 LLYKEYLSEKETWKT----ESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNA----LQMDS 872
L +E L E+E + E T + + +KLED++ + + + NN L+ L+
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI----LVMDDQNNKLSKERKLLEERI 1008
Query: 873 DEMKKILAENSRK---ITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVC 929
++ LAE K +T L+ +S+I + ++ E + R+E EK K +L ++
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 930 EKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI------LQKD 983
E+I LQ ++A K+ +K + +L+ L+ Q N K R++ LQ+D
Sbjct: 1069 EQIADLQA--QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 984 NMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKA 1043
L + E + L E++E++ ELE T + T +QE + E +
Sbjct: 1127 --LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-----QQELRAKREQEVTVL 1179
Query: 1044 KKSITNSDIVSISKKITMLEMKELNER------QRAEHCQKMYEHLRTSLKQMEERNFEL 1097
KK++ D + S + + EM++ + + ++ E ++ +L + + +E+ N +L
Sbjct: 1180 KKAL---DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236
Query: 1098 ETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLRE 1157
+ L + + + ++ L ++ + SK SD +R R EL +V KL+
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKC-SDGERARA--------ELNDKVHKLQN 1287
Query: 1158 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA 1217
+ + + K+V SL QL D Q +L Q +L+ +T
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ----------ELLQEETRQKLNVSTK 1337
Query: 1218 LGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSL---RRQF 1274
L +LE + LQ + +Q L+ L + + + + T+++L +++F
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 1275 SGALP-LAQQ--------EKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKL 1325
+ L QQ +K KT +LQ + ++ ++ N +Q N+E K + + L
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 1326 KGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNR---ELVKDKEEIKYLNNII-SE 1381
+ + S D + + + E + L L R E ++ KEE++ N ++ +E
Sbjct: 1458 AEEKNISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAE 1512
Query: 1382 YERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGS 1441
E +SS ++ V +N HE LE+ + Q E+ ++ E+ +
Sbjct: 1513 MEDLVSSKDD--VGKN-VHE------------LEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 1442 IPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKV 1501
D L +LE+ ++ +K L+ R + EEK ++ + L E +
Sbjct: 1558 TEDAKL----RLEVNMQALKGQFERDLQARD--EQNEEKRRQLQRQLHEYETELE----- 1606
Query: 1502 INELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQR 1561
+E + R A A ++KL +L K++E ++ +K + I +L + + +K +QR
Sbjct: 1607 -DERKQRALAAAAKKKLEGDL--KDLELQADSAIKGREEAIK----QLRKLQAQMKDFQR 1659
Query: 1562 LLEKAREEQREI---VKKHEEDLHILHHRL-ELQADSSLNKFKQTAWDLMKQSPTPVPTN 1617
LE AR + EI K++E+ L L +LQ D + + + DL
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL----------- 1708
Query: 1618 KHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHE 1677
E E+ E SLS + QD +R+ E QL+E E
Sbjct: 1709 -------EKEELAEELASSLSG-----RNALQDEKRRLEARIA----------QLEEELE 1746
Query: 1678 DEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALK 1737
+E ++A + ++ Q+++ S L +E ++ S +N + L+S+L
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN--KELRSKLHEM 1804
Query: 1738 EKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNEN 1797
E K+ ++ + A EE++ +K+A + D+ +E+ QVED +
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864
Query: 1798 LLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRL 1857
+ KE + R L L + E Q+ K+ RE +E + N+ + R++ L
Sbjct: 1865 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1924
Query: 1858 TSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLK 1898
S L+ N+ S + + +++ +G EE D +
Sbjct: 1925 KSKLR----RGNETSFVPSRRSGGRRVIENADGSEEETDTR 1961
Score = 152 bits (384), Expect = 4e-36
Identities = 256/1167 (21%), Positives = 487/1167 (41%), Gaps = 182/1167 (15%)
Query: 51 LFRITQSLMKMKAQEVELAL--EEVEKAGEEQAKFENQLKT---KVMKLENELEMAQQSA 105
LF + L+++ QE E+ +E++K E Q K EN+LK K +L E + Q+
Sbjct: 837 LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896
Query: 106 GGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRE 165
+ E ++ +L K +ELE++ E+E R EE E+ +L+ E
Sbjct: 897 QAETELYAEAE--EMRVRLAAKKQELEEILHEMEA----------RLEEEEDRGQQLQAE 944
Query: 166 NKRLKKK----NEQLCQDIIDYQK-QIDSQKETLLSRRGEDS-----DYRSQLSKKNYEL 215
K++ ++ EQL ++ QK Q++ ++ ED D ++LSK+ L
Sbjct: 945 RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1004
Query: 216 IQYLDEIQT-LTEANEKIE------------VQNQEMR-KNLEESVQEMEKM-------- 253
+ + ++ T L E EK + + E+R K E+S QE+EK+
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064
Query: 254 TDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKN----------------E 297
+D + ++ + Q + QL K+ + Q + L D + KN +
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124
Query: 298 EDDPIMVAVNAKVEEWKLILSSKDDEI----------IEYQQMLHNLREK----LKNAQL 343
ED A K E+ K L + + + QQ L RE+ LK A
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184
Query: 344 DADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQ 403
+ +S+ +Q+ Q+ ++ LTEQ+EQ+ + K L +NK TL +
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR-----------AKANLDKNK--QTLEK 1231
Query: 404 QTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVV 463
+ + + L +L + +E E + EA +E + + + + V+ L++ V
Sbjct: 1232 E-NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 464 EIKNCKNQIKIRDREIEILTKEINKLELKISDFLD-ENEALRERVGLEPKTMIDLTEFRN 522
+ N+ + + + L K++ L ++ D + E R+++ + K + L E RN
Sbjct: 1291 SVTGMLNEAEGKAIK---LAKDVASLSSQLQDTQELLQEETRQKLNVSTK-LRQLEEERN 1346
Query: 523 SKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQ-----ERGKRSATSGLTTEDL 577
S + + Q L + I +L + D KKK++ A E GK+ +
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI----- 1401
Query: 578 NLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIA---KFQ 634
EN++Q D L ++KN L +EL + DL+ R +++ K Q
Sbjct: 1402 ---ENLTQQYEEKAAAYDKLE-------KTKNR-LQQELDDLVVDLDNQRQLVSNLEKKQ 1450
Query: 635 NKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLER-LVNAIESKNAEG 693
K +L+ E K + A + + + + + ET + SL R L A+E+K E
Sbjct: 1451 RKFDQLLAEEKNISS-----KYADERDRAEAEAREKETKAL--SLARALEEALEAK--EE 1501
Query: 694 IFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQS 753
+ + LKA+++ L +++ + + E K Q+ + +++ LE E L+ +
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE---LQAT 1558
Query: 754 EGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFA 813
E + + + ++ + ++ L E E+K + L+ L +Y +
Sbjct: 1559 EDAKLRLE------------VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Query: 814 VIRHQQSL---LYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQM 870
R Q++L K+ + + + ++ + + + + Q+++ ++K++ L +
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666
Query: 871 DSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCE 930
DE+ EN +K L E L++ L ER RK+ + +K EL A
Sbjct: 1667 SRDEIFATAKENEKKAKSL---EADLMQLQEDLAAAER-ARKQADLEKEELAEELASSLS 1722
Query: 931 KIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRT 990
LQ K +IA L++ ELE ++ + R Q+ L
Sbjct: 1723 GRNALQDEKRRLEARIAQLEE---------ELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 991 SNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETK------------LGNES 1038
+ +N S ++Q+E NKEL + KLH +E A + + K L +
Sbjct: 1774 ATERSTAQKNESARQQLERQNKEL---RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830
Query: 1039 SMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1098
+ +K + KK+ + ++ +ER+ AE ++ E +KQ++ +LE
Sbjct: 1831 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR---QLE 1887
Query: 1099 TKFAELTKINLDAQKVEQMLRDELADS 1125
E +IN + +K+++ L DE +S
Sbjct: 1888 EAEEESQRINANRRKLQREL-DEATES 1913
Score = 149 bits (377), Expect = 3e-35
Identities = 226/1016 (22%), Positives = 429/1016 (42%), Gaps = 162/1016 (15%)
Query: 1542 IANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHE---EDLHILHHRL----ELQADS 1594
+ + + KE+ L+K + +KA E +E+ +KH E+ ++L +L EL A++
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 1595 SLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQ---DL 1651
+ + A KQ + L EME + E++D L + KK++Q DL
Sbjct: 907 EEMRVRLAA---KKQELEEI--------LHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 1652 ERQREITELKVKEFENIKLQLQE-NHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQA 1710
E Q L+ +E KLQL++ E ++KK++ E+ + ++ KE + L+ +
Sbjct: 956 EEQ-----LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010
Query: 1711 QKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQK 1770
TT + E+ K+ LK K + +S + L+ E + E + +
Sbjct: 1011 L--------TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1062
Query: 1771 EAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQ 1830
+A +QI D L+ Q+ +L L K +E L+ + R L D + NN L+K +
Sbjct: 1063 DASDFHEQIAD-----LQAQIAELKMQLAKKEEELQAALAR---LDDEIAQKNNALKKIR 1114
Query: 1831 KAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEG 1890
+ I +E++D E + K+ K+ L EEL+ +LE+ L+
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQ-------------KRDLGEELEALKTELEDTLDS 1161
Query: 1891 KVEEVDLKPMKEKNA---KEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLK 1947
+ +L+ +E+ K+ L EE + +A+++ +R K + E LT+QL K
Sbjct: 1162 TATQQELRAKREQEVTVLKKALD--EETRSHEAQVQEMRQKHAQAVEE---LTEQLEQFK 1216
Query: 1948 DLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQ 2007
A DK K TL+++ D +R L K+ E KK+ L+ + L +
Sbjct: 1217 RAKANLDKNKQTLEKE------NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 2008 A-LPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENL 2066
R + + +H ++ L + K ++ + S Q QEL +E
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ--LQDTQELLQEET 1328
Query: 2067 KLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKT 2126
+ + + + +L Q ++ L++Q+ + E + L++ + + +L S K
Sbjct: 1329 R---QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD------SKKK 1379
Query: 2127 IPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMA---NIEQENEKLKAELEKLKAH 2183
+ + T+ +++ ++ Q+E E L + EK A +E+ +L+ EL+ L
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQY----EEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 2184 LGHQ--LSMHYESKTKGTEKIIAENERLRKELKKETDAAE------------------KL 2223
L +Q L + E K + ++++AE + + + E D AE +
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 2224 RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYE--TKLKE 2281
AK LE N+ + ++E+ +LE + K + T+M E T+L+E
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS-----KRALETQMEEMKTQLEE 1550
Query: 2282 LETDIAKKNQSITDLK---QLVKEATERE-QKVNKYNEDLEQQIKILKHVPE-------- 2329
LE ++ + L+ Q +K ER+ Q ++ NE+ +Q++ H E
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610
Query: 2330 ----GAETEQGLKRELQVLRLANHQLDKEKAELIHQIE---------------------- 2363
A ++ L+ +L+ L L K + E I Q+
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE 1670
Query: 2364 ----ANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKL---KKELENF 2416
A +++ A+S D QL+E + E K +DLEK+ L EE+ + L++
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1730
Query: 2417 DPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEES 2472
I L+ +EE + ++V+K ++Q +L++ +A + ES
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ-AEQLSNELATERSTAQKNES 1785
Score = 143 bits (360), Expect = 2e-33
Identities = 209/1055 (19%), Positives = 445/1055 (42%), Gaps = 87/1055 (8%)
Query: 39 ELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL 98
E + E++E+ + + M + ++E LEE E A ++ + + K+ KLE+E+
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 987
Query: 99 EMA--QQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAE 156
+ Q + ++ + L I L L +++ + +++ K K + + +L +R ++ E
Sbjct: 988 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1047
Query: 157 NENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELI 216
+L + ++L+ + I D Q QI K L + + + ++ L++ + E+
Sbjct: 1048 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK---EEELQAALARLDDEIA 1104
Query: 217 QYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKK 276
Q + ++ + E I +++ + ++ D ++A+ + ++ +D
Sbjct: 1105 QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1164
Query: 277 ENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLRE 336
+ + + QE+T L K+ +EE + A+V+E + + +E+ E + +
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETR----SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 337 KLKNAQLDADKSN------VMALQQGIQERDSQIKMLTEQVEQYTKEM---EKNTCIIED 387
L + +K N + L Q QE + + K L QV++ + E+ + D
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 388 ----LKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVE 443
L+NE++ G ++ +K+ + L + ++ T EL + + R+K +
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD---TQELLQEETRQK----LN 1333
Query: 444 ALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEAL 503
+L+ E L+D + E K + +R I L +++ + K+ DF EAL
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 504 RERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQER 563
E K + +LT+ K + L +E++ L +DL + + ++
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV---VDLDNQRQLVSNLE 1447
Query: 564 GKRSATSGLTTEDLNLTENIS-QGDRIS----ERKLDLLS----LKNMSEAQSKNEFLSR 614
K+ L E+ N++ + + DR E++ LS L+ EA+ + E ++
Sbjct: 1448 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 615 ELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSL 674
L + DL S+ + K + EL + + LE M+E+ ++E+ E L
Sbjct: 1508 MLKAEMEDLVSSKDDVGK---NVHELEKSKRALETQMEEMKTQLEEL---------EDEL 1555
Query: 675 IIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQ-- 732
+L + + +G F+ L+A+ +Q + +L+++L E E + +Q
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERD--LQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1613
Query: 733 ---LAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQ 789
AK L+ D + E +G K + + +
Sbjct: 1614 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA 1673
Query: 790 ELENKEKKLKNLEDSLEDYNRKFAVIR--HQQSLLYKEYLSEKETWKTESK-TIKEEKRK 846
+ EKK K+LE L A +Q+ L KE L+E+ + +++EKR+
Sbjct: 1674 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 847 LEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVEL 906
LE ++ Q +++E + A+ SD ++K + + L + + + +L
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAM---SDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790
Query: 907 ERQ---LRKE--------NEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDN 955
ERQ LR + K K+ + ++EA++ + ++ ++ A K AA + +
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ---LEEQVEQEAREKQAATKSLKQK 1847
Query: 956 SVSLSELELANKQYNELTAKYRDILQKDNMLV-QRTSNLEHLECENISLKEQVESINKEL 1014
L E+ L + ++ +Y++ +K N V Q LE E E+ + + +EL
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Query: 1015 EITKEKLHTIEQ---AWEQETKLGNESSMDKAKKS 1046
+ E + + A + + + GNE+S +++S
Sbjct: 1908 DEATESNEAMGREVNALKSKLRRGNETSFVPSRRS 1942
Score = 120 bits (301), Expect = 2e-26
Identities = 193/835 (23%), Positives = 351/835 (42%), Gaps = 131/835 (15%)
Query: 1646 KVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLK 1705
KV L+ R+ E++ KE E LQ+ E + +K + E+++L+ Q +E L+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDE-----LQKTKERQ-QKAENELKELEQKHSQLTEEKNLLQ 893
Query: 1706 SELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIIS 1765
+LQA+ E + A E ++ +LA K+++ L L E+ A + EE
Sbjct: 894 EQLQAETELYAEA---------EEMRVRLAAKKQE---LEEILHEMEARLE---EEEDRG 938
Query: 1766 ATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNL---NDL 1822
Q E QQ++D L+ Q+E+ KL+ T++ + L D + +D
Sbjct: 939 QQLQAERKKMAQQMLD-----LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993
Query: 1823 NNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVK 1882
NN+L K++K L+ +I LT+ L + EE + +
Sbjct: 994 NNKLSKERKL-----------------LEERISDLTTNLAEE----------EEKAKNLT 1026
Query: 1883 KLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQ 1942
KL+N+ E + E++++ KE+ +++EL +K + K+EG + E ++ L Q
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDASDFHE---QIADLQAQ 1077
Query: 1943 LNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILY 2002
+ LK AK ++E +L + L K++ EL+ DL+ D+
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNAL--------KKIRELEGHISDLQEDLDS 1129
Query: 2003 MRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQ 2062
RA + Q R L E+L AL+ + +DT + + + +REQE+
Sbjct: 1130 ERAAR--------NKAEKQKRDLGEELEALKTEL-EDTLDS---TATQQELRAKREQEVT 1177
Query: 2063 KENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGR 2122
L E + Q+++ + + V +L E E K+ KA + +
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQ---KHAQAVEELTEQLEQFKRAKANLDK---------- 1224
Query: 2123 SGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKA 2182
+ +T+ + + +V+ + ++E E KK E + + E+ +AEL
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS-DGERARAELNDKV- 1282
Query: 2183 HLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLE 2242
H+L ES T NE K +K D A ++ E+L E+ +L
Sbjct: 1283 ---HKLQNEVESVTGML------NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333
Query: 2243 ETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKE 2302
+ K Q E R + D + + + E + L ++ + + D V+
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEE----MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 2303 ATEREQKVNKYNEDLEQQIKILKHVPEGAE-TEQGLKRELQVLRLANHQLDKEKAELIHQ 2361
E +++ K E+L QQ + + E T+ L++EL L + LD ++ +L+
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV---DLDNQR-QLVSN 1445
Query: 2362 IEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQ-------HLKEEIKKLKKELE 2414
+E K Q + + + + K D + + EK+ EE + K+ELE
Sbjct: 1446 LE--KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1503
Query: 2415 NFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDE 2469
+ E+EDL + K++V KN+ EK K+ E E+ + + EE EDE
Sbjct: 1504 RTNKMLKAEMEDL-VSSKDDVGKNVHELEKSKRALETQMEEMKTQL---EELEDE 1554
Score = 113 bits (282), Expect = 3e-24
Identities = 156/737 (21%), Positives = 306/737 (41%), Gaps = 66/737 (8%)
Query: 34 KVEVNELKSEKQENVIHLFRITQSLMKMKAQ----EVELALEEVEKAGE----EQAKFEN 85
+ +V E++ + + V L + + KA + L E + AGE QAK E
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250
Query: 86 QLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVN 145
+ K K ++ + + ++ S G R L +++ +L+ ++E L + E + K K
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 146 EQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYR 205
L+ + ++ + + R+ + K QL ++ Q Q+D + E + S
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 206 SQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKA--- 262
QLS +L + ++ L E ++ + + + + + EE +K+ NR++
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430
Query: 263 -IVHQTDN----VIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWK-LI 316
+V DN V + KK+ QL +E K +E D A+ +E K L
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD---RAEAEAREKETKALS 1487
Query: 317 LSSKDDEIIEYQQMLHNLREKLKNAQLDADKS------NVMALQQGIQERDSQIKMLTEQ 370
L+ +E +E ++ L + LK D S NV L++ + ++Q++ + Q
Sbjct: 1488 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1547
Query: 371 VEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELA 430
+E+ E++ ED K L+ N A L Q +Q+ + +EK ++ +R
Sbjct: 1548 LEELEDELQAT----EDAKLRLEVNMQA--LKGQFERDLQARDEQNEEKRRQLQRQLHEY 1601
Query: 431 EADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLE 490
E + ++ K+ A K E + LE + IK R+ I K++ KL+
Sbjct: 1602 ETELEDERKQRALAAAAKKKLEGDLKDLE------LQADSAIKGREEAI----KQLRKLQ 1651
Query: 491 LKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERL 550
++ DF E E R + I T N K K + A+ L +++ + E R
Sbjct: 1652 AQMKDFQRELEDAR-----ASRDEIFATAKENEK--KAKSLEADLMQLQEDLAAAERARK 1704
Query: 551 DLKKKIRQMAQE-RGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKN 609
+ ++A+E S + L E L I+Q + E + NM +
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG-----NMEAMSDRV 1759
Query: 610 EFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKG 669
+++ + +L R+ K ++ ++L +NK+L + E+ A+K K
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS----- 1814
Query: 670 GETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINY 729
I +LE + +E + + + K+ + Q + +E+ ++ + RK A Y
Sbjct: 1815 -----TIAALEAKIAQLEEQVEQEAREKQAATKS-LKQKDKKLKEILLQVEDERKMAEQY 1868
Query: 730 SQQLAKANLKIDHLEKE 746
+Q K N ++ L+++
Sbjct: 1869 KEQAEKGNARVKQLKRQ 1885
Score = 82.4 bits (202), Expect = 5e-15
Identities = 98/469 (20%), Positives = 199/469 (42%), Gaps = 38/469 (8%)
Query: 4 NINWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKA 63
NI+ K + D + +E+ L ++ + E E K E + L + L+ K
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK- 1520
Query: 64 QEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL----------EMAQQSAGGRDTRFL 113
+V + E+EK+ ++KT++ +LE+EL E+ Q+ G+ R L
Sbjct: 1521 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1580
Query: 114 RNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKN 173
+ Q E++ Q R+L + E ELE E+K A ++ E + L + K
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1640
Query: 174 EQLCQDIIDYQKQI-DSQKETLLSRRGEDSDY----RSQLSKKNYE--LIQYLDEIQTLT 226
E+ + + Q Q+ D Q+E +R D + ++ K+ E L+Q +++
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 227 EANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQ----LKKENDHYQ 282
A ++ +++ +E+ + L S+ + DE R++A + Q + +++ ++ +D +
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 283 LQVQELTDLLKSKNEEDDPIMVAVNAK--VEEWKLILSSKDDEI-----IEYQQMLHNLR 335
Q+ L E +A+ +E L SK E+ +++ + L
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 336 EKLKNA--QLDADKSNVMALQQGIQERDSQIKMLTEQVE-------QYTKEMEKNTCIIE 386
K+ Q++ + A + ++++D ++K + QVE QY ++ EK ++
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1880
Query: 387 DLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAR 435
LK +L+ + S K+Q LD E + R ++ R
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 76.6 bits (187), Expect = 3e-13
Identities = 104/448 (23%), Positives = 199/448 (44%), Gaps = 47/448 (10%)
Query: 2040 TYSKPSISGIESDDHCQ-REQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKE 2098
T KP + ++ Q +E ELQK + ELK +LEQ + L KN +++ +
Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQ 897
Query: 2099 MCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGIL 2158
L E E++ +L + ELE+ + M+ +E+ + +QL+ A
Sbjct: 898 AETELYAEAEEMRVRLAAKK---------QELEEILHEMEARLEEEEDRGQQLQ-AERKK 947
Query: 2159 TSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIA----ENERLRKELK 2214
+++M ++E++ E+ +A +KL+ + E+K K E I +N +L KE K
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLE-----KVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 2215 K--------ETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSW 2266
T+ AE+ AKN L L K + E RL+ E +LE
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEK------ 1055
Query: 2267 KSIVVTRMYETKLKELETDIAKKNQSITDLK-QLVKEATEREQKVNKYNEDLEQQIKILK 2325
+ R E + IA I +LK QL K+ E + + + ++++ Q+ LK
Sbjct: 1056 ----LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111
Query: 2326 HVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKD--QSGAESTIPDADQLKE 2383
+ E L+ +L R A ++ +K+K +L ++EA K + +ST + +
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1171
Query: 2384 KIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEE 2443
+ +++ K D E + + ++++++++ E++E K K + KN ++
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK-RAKANLDKN---KQ 1227
Query: 2444 KVKKLSEQLGVELTSPVAASEEFEDEEE 2471
++K + L EL A +E E +++
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKK 1255
Score = 50.8 bits (120), Expect = 2e-05
Identities = 54/226 (23%), Positives = 106/226 (46%), Gaps = 37/226 (16%)
Query: 21 QEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSL------MKMKAQEVELALEEVE 74
+EELA+ L SLS N L+ EK+ + ++ + L M+ + V A ++ E
Sbjct: 1710 KEELAEELASSLSGR--NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 75 KAGEEQA--------------KFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQL 120
+ E A + E Q K KL +E+E A +S L +I QL
Sbjct: 1768 QLSNELATERSTAQKNESARQQLERQNKELRSKL-HEMEGAVKSKFKSTIAALEAKIAQL 1826
Query: 121 EKQLEQ--------------KDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRREN 166
E+Q+EQ KD++L+++ ++E E+K+ EQ + E+ +L+R+
Sbjct: 1827 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1886
Query: 167 KRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKN 212
+ +++++++ + Q+++D E+ + E + +S+L + N
Sbjct: 1887 EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1932
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 172 bits (436), Expect = 4e-42
Identities = 245/1212 (20%), Positives = 513/1212 (42%), Gaps = 133/1212 (10%)
Query: 1244 EKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQE 1303
+++Q L ++ RN A +L+ R F+ PL Q + + M +++ K +
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874
Query: 1304 MKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQEL--KL 1361
+ ++ E + +E K ++ + L+E + + + + + ++ L+E+ ++
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934
Query: 1362 NRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREV---DLERQL 1418
L ++++ + L + + + LEE++ ++ ++ Q+ E LE ++
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 994
Query: 1419 DIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIA--LRKIK-ENIRIILETRATCK 1475
+ D Q N++ + EE I D + L + E A L K+K ++ +I E K
Sbjct: 995 LVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051
Query: 1476 SLEEKLKEKESALRLAEQNILSRDKVINELR-----LRLPATAEREKLIAELGRKEMEPK 1530
E+ +E E R E + + I +L+ L++ + E+L A L R + E
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111
Query: 1531 SHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 1590
+ A + I ++ ++ +E L + KA +++R++ E+L L LE
Sbjct: 1112 QKNN---ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL----GEELEALKTELED 1164
Query: 1591 QADSSLN----KFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKK 1646
DS+ + K+ + + T H ++ EM Q A+ + L+ L + K+
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 1647 VSQDLERQREITELKVKEFE---NIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQC 1703
+L++ ++ E + + + Q ++ E + KK++A+V++L+ ++
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 1704 LKSELQAQKEANSRAPTTTMRNLVE-----------RLKSQLALKEKQQKALSRALLELR 1752
L ++ K N T M N E L SQL ++ + +R L +
Sbjct: 1285 LNDKV--HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342
Query: 1753 AEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRE 1812
++ EER S Q + + +Q ++RH L Q+ D + L ++ + +
Sbjct: 1343 TKLRQLEEER-NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1401
Query: 1813 NSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQS 1872
+ +L + ++K AY+K+ + K + QE D+L + DN++
Sbjct: 1402 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL-------------DNQRQ 1448
Query: 1873 LIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEK 1932
L+ L++K +K + QL + + + K E++ E R E+ K + + L+ K
Sbjct: 1449 LVSNLEKKQRKFD-QLLAEEKNISSKYADERDRAEAEAR-EKETKALSLARALEEALEAK 1506
Query: 1933 EGEVFTLTKQLNT-LKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKK 1991
E E+ K L ++DL + D + K+ + L + E + +LEEL+
Sbjct: 1507 E-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS-----KRALETQMEEMKTQLEELED 1560
Query: 1992 RNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIES 2051
E+ L + + + DL ++ +EK L++Q + E+
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE----------YET 1610
Query: 2052 DDHCQREQE----LQKENLKLSSENIELKFQ-----LEQANKDLPRLKNQVRDLKEMCEF 2102
+ +R+Q K+ L+ +++EL+ E+A K L +L+ Q++D + E
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 2103 LKKEKAEVQRKLGHVRGSGRSGKT-IPELEKTIGLMKKVVEKVQRENEQLKKASGILTSE 2161
+ + E+ +S + + +L++ + ++ ++ E E+L + S
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 2162 KMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAE 2221
+ A ++ E +L+A + +L+ L + + E+ + K + E+L EL E A+
Sbjct: 1731 RNA-LQDEKRRLEARIAQLEEELEEEQG-NMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 2222 KLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKE 2281
K A+ LE N+++ +L E +EGA +KS + E K+ +
Sbjct: 1789 KNESARQQLERQNKELRSKLHE--------------MEGAVKSKFKSTIAA--LEAKIAQ 1832
Query: 2282 LETDI---AKKNQSIT--------DLKQLVKEATEREQKVNKYNEDLEQ---QIKILKHV 2327
LE + A++ Q+ T LK+++ + + + +Y E E+ ++K LK
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 2328 PEGAETE--------QGLKRELQVLRLANHQLDKEKAELIHQIEANKD-------QSGAE 2372
E AE E + L+REL +N + +E L ++ + +SG
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGR 1952
Query: 2373 STIPDADQLKEK 2384
I +AD +E+
Sbjct: 1953 RVIENADGSEEE 1964
Score = 171 bits (433), Expect = 8e-42
Identities = 270/1241 (21%), Positives = 525/1241 (42%), Gaps = 176/1241 (14%)
Query: 701 LKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVF 760
++A+ D+L E ++ E ++ +SQ + NL + L+ ET L ++E V
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR- 919
Query: 761 KGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQS 820
+ ++ + L +L E+E + ++ ++ L+ +K A QQ
Sbjct: 920 ----------------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA----QQM 959
Query: 821 LLYKEYLSEKETWKT----ESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNA----LQMDS 872
L +E L E+E + E T + + +KLED++ + + + NN L+ L+
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI----LVMDDQNNKLSKERKLLEERI 1015
Query: 873 DEMKKILAENSRK---ITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVC 929
++ LAE K +T L+ +S+I + ++ E + R+E EK K +L ++
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 930 EKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI------LQKD 983
E+I LQ ++A K+ +K + +L+ L+ Q N K R++ LQ+D
Sbjct: 1076 EQIADLQA--QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 984 NMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKA 1043
L + E + L E++E++ ELE T + T +QE + E +
Sbjct: 1134 --LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-----QQELRAKREQEVTVL 1186
Query: 1044 KKSITNSDIVSISKKITMLEMKELNER------QRAEHCQKMYEHLRTSLKQMEERNFEL 1097
KK++ D + S + + EM++ + + ++ E ++ +L + + +E+ N +L
Sbjct: 1187 KKAL---DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243
Query: 1098 ETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLRE 1157
+ L + + + ++ L ++ + SK SD +R R EL +V KL+
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKC-SDGERARA--------ELNDKVHKLQN 1294
Query: 1158 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA 1217
+ + + K+V SL QL D Q +L Q +L+ +T
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ----------ELLQEETRQKLNVSTK 1344
Query: 1218 LGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSL---RRQF 1274
L +LE + LQ + +Q L+ L + + + + T+++L +++F
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 1275 SGALP-LAQQ--------EKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKL 1325
+ L QQ +K KT +LQ + ++ ++ N +Q N+E K + + L
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 1326 KGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNR---ELVKDKEEIKYLNNII-SE 1381
+ + S D + + + E + L L R E ++ KEE++ N ++ +E
Sbjct: 1465 AEEKNISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAE 1519
Query: 1382 YERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGS 1441
E +SS ++ V +N HE LE+ + Q E+ ++ E+ +
Sbjct: 1520 MEDLVSSKDD--VGKN-VHE------------LEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 1442 IPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKV 1501
D L +LE+ ++ +K L+ R + EEK ++ + L E +
Sbjct: 1565 TEDAKL----RLEVNMQALKGQFERDLQARD--EQNEEKRRQLQRQLHEYETELE----- 1613
Query: 1502 INELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQR 1561
+E + R A A ++KL +L K++E ++ +K + I +L + + +K +QR
Sbjct: 1614 -DERKQRALAAAAKKKLEGDL--KDLELQADSAIKGREEAIK----QLRKLQAQMKDFQR 1666
Query: 1562 LLEKAREEQREI---VKKHEEDLHILHHRL-ELQADSSLNKFKQTAWDLMKQSPTPVPTN 1617
LE AR + EI K++E+ L L +LQ D + + + DL
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL----------- 1715
Query: 1618 KHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHE 1677
E E+ E SLS + QD +R+ E QL+E E
Sbjct: 1716 -------EKEELAEELASSLSG-----RNALQDEKRRLEARIA----------QLEEELE 1753
Query: 1678 DEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALK 1737
+E ++A + ++ Q+++ S L +E ++ S +N + L+S+L
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN--KELRSKLHEM 1811
Query: 1738 EKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNEN 1797
E K+ ++ + A EE++ +K+A + D+ +E+ QVED +
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871
Query: 1798 LLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRL 1857
+ KE + R L L + E Q+ K+ RE +E + N+ + R++ L
Sbjct: 1872 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1931
Query: 1858 TSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLK 1898
S L+ N+ S + + +++ +G EE D +
Sbjct: 1932 KSKLR----RGNETSFVPSRRSGGRRVIENADGSEEETDTR 1968
Score = 152 bits (384), Expect = 4e-36
Identities = 256/1167 (21%), Positives = 487/1167 (41%), Gaps = 182/1167 (15%)
Query: 51 LFRITQSLMKMKAQEVELAL--EEVEKAGEEQAKFENQLKT---KVMKLENELEMAQQSA 105
LF + L+++ QE E+ +E++K E Q K EN+LK K +L E + Q+
Sbjct: 844 LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903
Query: 106 GGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRE 165
+ E ++ +L K +ELE++ E+E R EE E+ +L+ E
Sbjct: 904 QAETELYAEAE--EMRVRLAAKKQELEEILHEMEA----------RLEEEEDRGQQLQAE 951
Query: 166 NKRLKKK----NEQLCQDIIDYQK-QIDSQKETLLSRRGEDS-----DYRSQLSKKNYEL 215
K++ ++ EQL ++ QK Q++ ++ ED D ++LSK+ L
Sbjct: 952 RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011
Query: 216 IQYLDEIQT-LTEANEKIE------------VQNQEMR-KNLEESVQEMEKM-------- 253
+ + ++ T L E EK + + E+R K E+S QE+EK+
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071
Query: 254 TDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKN----------------E 297
+D + ++ + Q + QL K+ + Q + L D + KN +
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 298 EDDPIMVAVNAKVEEWKLILSSKDDEI----------IEYQQMLHNLREK----LKNAQL 343
ED A K E+ K L + + + QQ L RE+ LK A
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191
Query: 344 DADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQ 403
+ +S+ +Q+ Q+ ++ LTEQ+EQ+ + K L +NK TL +
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR-----------AKANLDKNK--QTLEK 1238
Query: 404 QTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVV 463
+ + + L +L + +E E + EA +E + + + + V+ L++ V
Sbjct: 1239 E-NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 464 EIKNCKNQIKIRDREIEILTKEINKLELKISDFLD-ENEALRERVGLEPKTMIDLTEFRN 522
+ N+ + + + L K++ L ++ D + E R+++ + K + L E RN
Sbjct: 1298 SVTGMLNEAEGKAIK---LAKDVASLSSQLQDTQELLQEETRQKLNVSTK-LRQLEEERN 1353
Query: 523 SKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQ-----ERGKRSATSGLTTEDL 577
S + + Q L + I +L + D KKK++ A E GK+ +
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI----- 1408
Query: 578 NLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIA---KFQ 634
EN++Q D L ++KN L +EL + DL+ R +++ K Q
Sbjct: 1409 ---ENLTQQYEEKAAAYDKLE-------KTKNR-LQQELDDLVVDLDNQRQLVSNLEKKQ 1457
Query: 635 NKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLER-LVNAIESKNAEG 693
K +L+ E K + A + + + + + ET + SL R L A+E+K E
Sbjct: 1458 RKFDQLLAEEKNISS-----KYADERDRAEAEAREKETKAL--SLARALEEALEAK--EE 1508
Query: 694 IFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQS 753
+ + LKA+++ L +++ + + E K Q+ + +++ LE E L+ +
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE---LQAT 1565
Query: 754 EGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFA 813
E + + + ++ + ++ L E E+K + L+ L +Y +
Sbjct: 1566 EDAKLRLE------------VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Query: 814 VIRHQQSL---LYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQM 870
R Q++L K+ + + + ++ + + + + Q+++ ++K++ L +
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1673
Query: 871 DSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCE 930
DE+ EN +K L E L++ L ER RK+ + +K EL A
Sbjct: 1674 SRDEIFATAKENEKKAKSL---EADLMQLQEDLAAAER-ARKQADLEKEELAEELASSLS 1729
Query: 931 KIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRT 990
LQ K +IA L++ ELE ++ + R Q+ L
Sbjct: 1730 GRNALQDEKRRLEARIAQLEE---------ELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 991 SNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETK------------LGNES 1038
+ +N S ++Q+E NKEL + KLH +E A + + K L +
Sbjct: 1781 ATERSTAQKNESARQQLERQNKEL---RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1837
Query: 1039 SMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1098
+ +K + KK+ + ++ +ER+ AE ++ E +KQ++ +LE
Sbjct: 1838 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR---QLE 1894
Query: 1099 TKFAELTKINLDAQKVEQMLRDELADS 1125
E +IN + +K+++ L DE +S
Sbjct: 1895 EAEEESQRINANRRKLQREL-DEATES 1920
Score = 149 bits (377), Expect = 3e-35
Identities = 226/1016 (22%), Positives = 429/1016 (42%), Gaps = 162/1016 (15%)
Query: 1542 IANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHE---EDLHILHHRL----ELQADS 1594
+ + + KE+ L+K + +KA E +E+ +KH E+ ++L +L EL A++
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 1595 SLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQ---DL 1651
+ + A KQ + L EME + E++D L + KK++Q DL
Sbjct: 914 EEMRVRLAA---KKQELEEI--------LHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 1652 ERQREITELKVKEFENIKLQLQE-NHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQA 1710
E Q L+ +E KLQL++ E ++KK++ E+ + ++ KE + L+ +
Sbjct: 963 EEQ-----LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017
Query: 1711 QKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQK 1770
TT + E+ K+ LK K + +S + L+ E + E + +
Sbjct: 1018 L--------TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1069
Query: 1771 EAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQ 1830
+A +QI D L+ Q+ +L L K +E L+ + R L D + NN L+K +
Sbjct: 1070 DASDFHEQIAD-----LQAQIAELKMQLAKKEEELQAALAR---LDDEIAQKNNALKKIR 1121
Query: 1831 KAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEG 1890
+ I +E++D E + K+ K+ L EEL+ +LE+ L+
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQ-------------KRDLGEELEALKTELEDTLDS 1168
Query: 1891 KVEEVDLKPMKEKNA---KEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLK 1947
+ +L+ +E+ K+ L EE + +A+++ +R K + E LT+QL K
Sbjct: 1169 TATQQELRAKREQEVTVLKKALD--EETRSHEAQVQEMRQKHAQAVEE---LTEQLEQFK 1223
Query: 1948 DLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQ 2007
A DK K TL+++ D +R L K+ E KK+ L+ + L +
Sbjct: 1224 RAKANLDKNKQTLEKE------NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 2008 A-LPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENL 2066
R + + +H ++ L + K ++ + S Q QEL +E
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ--LQDTQELLQEET 1335
Query: 2067 KLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKT 2126
+ + + + +L Q ++ L++Q+ + E + L++ + + +L S K
Sbjct: 1336 R---QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD------SKKK 1386
Query: 2127 IPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMA---NIEQENEKLKAELEKLKAH 2183
+ + T+ +++ ++ Q+E E L + EK A +E+ +L+ EL+ L
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQY----EEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 2184 LGHQ--LSMHYESKTKGTEKIIAENERLRKELKKETDAAE------------------KL 2223
L +Q L + E K + ++++AE + + + E D AE +
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 2224 RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYE--TKLKE 2281
AK LE N+ + ++E+ +LE + K + T+M E T+L+E
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS-----KRALETQMEEMKTQLEE 1557
Query: 2282 LETDIAKKNQSITDLK---QLVKEATERE-QKVNKYNEDLEQQIKILKHVPE-------- 2329
LE ++ + L+ Q +K ER+ Q ++ NE+ +Q++ H E
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617
Query: 2330 ----GAETEQGLKRELQVLRLANHQLDKEKAELIHQIE---------------------- 2363
A ++ L+ +L+ L L K + E I Q+
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE 1677
Query: 2364 ----ANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKL---KKELENF 2416
A +++ A+S D QL+E + E K +DLEK+ L EE+ + L++
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1737
Query: 2417 DPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEES 2472
I L+ +EE + ++V+K ++Q +L++ +A + ES
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ-AEQLSNELATERSTAQKNES 1792
Score = 143 bits (360), Expect = 2e-33
Identities = 209/1055 (19%), Positives = 445/1055 (42%), Gaps = 87/1055 (8%)
Query: 39 ELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL 98
E + E++E+ + + M + ++E LEE E A ++ + + K+ KLE+E+
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 994
Query: 99 EMA--QQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAE 156
+ Q + ++ + L I L L +++ + +++ K K + + +L +R ++ E
Sbjct: 995 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1054
Query: 157 NENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELI 216
+L + ++L+ + I D Q QI K L + + + ++ L++ + E+
Sbjct: 1055 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK---EEELQAALARLDDEIA 1111
Query: 217 QYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKK 276
Q + ++ + E I +++ + ++ D ++A+ + ++ +D
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1171
Query: 277 ENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLRE 336
+ + + QE+T L K+ +EE + A+V+E + + +E+ E + +
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETR----SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227
Query: 337 KLKNAQLDADKSN------VMALQQGIQERDSQIKMLTEQVEQYTKEM---EKNTCIIED 387
L + +K N + L Q QE + + K L QV++ + E+ + D
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 388 ----LKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVE 443
L+NE++ G ++ +K+ + L + ++ T EL + + R+K +
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD---TQELLQEETRQK----LN 1340
Query: 444 ALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEAL 503
+L+ E L+D + E K + +R I L +++ + K+ DF EAL
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 504 RERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQER 563
E K + +LT+ K + L +E++ L +DL + + ++
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV---VDLDNQRQLVSNLE 1454
Query: 564 GKRSATSGLTTEDLNLTENIS-QGDRIS----ERKLDLLS----LKNMSEAQSKNEFLSR 614
K+ L E+ N++ + + DR E++ LS L+ EA+ + E ++
Sbjct: 1455 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 615 ELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSL 674
L + DL S+ + K + EL + + LE M+E+ ++E+ E L
Sbjct: 1515 MLKAEMEDLVSSKDDVGK---NVHELEKSKRALETQMEEMKTQLEEL---------EDEL 1562
Query: 675 IIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQ-- 732
+L + + +G F+ L+A+ +Q + +L+++L E E + +Q
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERD--LQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1620
Query: 733 ---LAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQ 789
AK L+ D + E +G K + + +
Sbjct: 1621 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA 1680
Query: 790 ELENKEKKLKNLEDSLEDYNRKFAVIR--HQQSLLYKEYLSEKETWKTESK-TIKEEKRK 846
+ EKK K+LE L A +Q+ L KE L+E+ + +++EKR+
Sbjct: 1681 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 847 LEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVEL 906
LE ++ Q +++E + A+ SD ++K + + L + + + +L
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAM---SDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797
Query: 907 ERQ---LRKE--------NEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDN 955
ERQ LR + K K+ + ++EA++ + ++ ++ A K AA + +
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ---LEEQVEQEAREKQAATKSLKQK 1854
Query: 956 SVSLSELELANKQYNELTAKYRDILQKDNMLV-QRTSNLEHLECENISLKEQVESINKEL 1014
L E+ L + ++ +Y++ +K N V Q LE E E+ + + +EL
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Query: 1015 EITKEKLHTIEQ---AWEQETKLGNESSMDKAKKS 1046
+ E + + A + + + GNE+S +++S
Sbjct: 1915 DEATESNEAMGREVNALKSKLRRGNETSFVPSRRS 1949
Score = 120 bits (301), Expect = 2e-26
Identities = 193/835 (23%), Positives = 351/835 (42%), Gaps = 131/835 (15%)
Query: 1646 KVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLK 1705
KV L+ R+ E++ KE E LQ+ E + +K + E+++L+ Q +E L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDE-----LQKTKERQ-QKAENELKELEQKHSQLTEEKNLLQ 900
Query: 1706 SELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIIS 1765
+LQA+ E + A E ++ +LA K+++ L L E+ A + EE
Sbjct: 901 EQLQAETELYAEA---------EEMRVRLAAKKQE---LEEILHEMEARLE---EEEDRG 945
Query: 1766 ATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNL---NDL 1822
Q E QQ++D L+ Q+E+ KL+ T++ + L D + +D
Sbjct: 946 QQLQAERKKMAQQMLD-----LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000
Query: 1823 NNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVK 1882
NN+L K++K L+ +I LT+ L + EE + +
Sbjct: 1001 NNKLSKERKL-----------------LEERISDLTTNLAEE----------EEKAKNLT 1033
Query: 1883 KLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQ 1942
KL+N+ E + E++++ KE+ +++EL +K + K+EG + E ++ L Q
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDASDFHE---QIADLQAQ 1084
Query: 1943 LNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILY 2002
+ LK AK ++E +L + L K++ EL+ DL+ D+
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNAL--------KKIRELEGHISDLQEDLDS 1136
Query: 2003 MRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQ 2062
RA + Q R L E+L AL+ + +DT + + + +REQE+
Sbjct: 1137 ERAAR--------NKAEKQKRDLGEELEALKTEL-EDTLDS---TATQQELRAKREQEVT 1184
Query: 2063 KENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGR 2122
L E + Q+++ + + V +L E E K+ KA + +
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQ---KHAQAVEELTEQLEQFKRAKANLDK---------- 1231
Query: 2123 SGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKA 2182
+ +T+ + + +V+ + ++E E KK E + + E+ +AEL
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS-DGERARAELNDKV- 1289
Query: 2183 HLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLE 2242
H+L ES T NE K +K D A ++ E+L E+ +L
Sbjct: 1290 ---HKLQNEVESVTGML------NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340
Query: 2243 ETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKE 2302
+ K Q E R + D + + + E + L ++ + + D V+
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEE----MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 2303 ATEREQKVNKYNEDLEQQIKILKHVPEGAE-TEQGLKRELQVLRLANHQLDKEKAELIHQ 2361
E +++ K E+L QQ + + E T+ L++EL L + LD ++ +L+
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV---DLDNQR-QLVSN 1452
Query: 2362 IEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQ-------HLKEEIKKLKKELE 2414
+E K Q + + + + K D + + EK+ EE + K+ELE
Sbjct: 1453 LE--KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1510
Query: 2415 NFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDE 2469
+ E+EDL + K++V KN+ EK K+ E E+ + + EE EDE
Sbjct: 1511 RTNKMLKAEMEDL-VSSKDDVGKNVHELEKSKRALETQMEEMKTQL---EELEDE 1561
Score = 113 bits (282), Expect = 3e-24
Identities = 156/737 (21%), Positives = 306/737 (41%), Gaps = 66/737 (8%)
Query: 34 KVEVNELKSEKQENVIHLFRITQSLMKMKAQ----EVELALEEVEKAGE----EQAKFEN 85
+ +V E++ + + V L + + KA + L E + AGE QAK E
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257
Query: 86 QLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVN 145
+ K K ++ + + ++ S G R L +++ +L+ ++E L + E + K K
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 146 EQLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYR 205
L+ + ++ + + R+ + K QL ++ Q Q+D + E + S
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 206 SQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKA--- 262
QLS +L + ++ L E ++ + + + + + EE +K+ NR++
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437
Query: 263 -IVHQTDN----VIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWK-LI 316
+V DN V + KK+ QL +E K +E D A+ +E K L
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD---RAEAEAREKETKALS 1494
Query: 317 LSSKDDEIIEYQQMLHNLREKLKNAQLDADKS------NVMALQQGIQERDSQIKMLTEQ 370
L+ +E +E ++ L + LK D S NV L++ + ++Q++ + Q
Sbjct: 1495 LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQ 1554
Query: 371 VEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELA 430
+E+ E++ ED K L+ N A L Q +Q+ + +EK ++ +R
Sbjct: 1555 LEELEDELQAT----EDAKLRLEVNMQA--LKGQFERDLQARDEQNEEKRRQLQRQLHEY 1608
Query: 431 EADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLE 490
E + ++ K+ A K E + LE + IK R+ I K++ KL+
Sbjct: 1609 ETELEDERKQRALAAAAKKKLEGDLKDLE------LQADSAIKGREEAI----KQLRKLQ 1658
Query: 491 LKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERL 550
++ DF E E R + I T N K K + A+ L +++ + E R
Sbjct: 1659 AQMKDFQRELEDAR-----ASRDEIFATAKENEK--KAKSLEADLMQLQEDLAAAERARK 1711
Query: 551 DLKKKIRQMAQE-RGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKN 609
+ ++A+E S + L E L I+Q + E + NM +
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQG-----NMEAMSDRV 1766
Query: 610 EFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKG 669
+++ + +L R+ K ++ ++L +NK+L + E+ A+K K
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS----- 1821
Query: 670 GETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINY 729
I +LE + +E + + + K+ + Q + +E+ ++ + RK A Y
Sbjct: 1822 -----TIAALEAKIAQLEEQVEQEAREKQAATKS-LKQKDKKLKEILLQVEDERKMAEQY 1875
Query: 730 SQQLAKANLKIDHLEKE 746
+Q K N ++ L+++
Sbjct: 1876 KEQAEKGNARVKQLKRQ 1892
Score = 82.4 bits (202), Expect = 5e-15
Identities = 98/469 (20%), Positives = 199/469 (42%), Gaps = 38/469 (8%)
Query: 4 NINWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKA 63
NI+ K + D + +E+ L ++ + E E K E + L + L+ K
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK- 1527
Query: 64 QEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL----------EMAQQSAGGRDTRFL 113
+V + E+EK+ ++KT++ +LE+EL E+ Q+ G+ R L
Sbjct: 1528 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1587
Query: 114 RNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKN 173
+ Q E++ Q R+L + E ELE E+K A ++ E + L + K
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1647
Query: 174 EQLCQDIIDYQKQI-DSQKETLLSRRGEDSDY----RSQLSKKNYE--LIQYLDEIQTLT 226
E+ + + Q Q+ D Q+E +R D + ++ K+ E L+Q +++
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 227 EANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQ----LKKENDHYQ 282
A ++ +++ +E+ + L S+ + DE R++A + Q + +++ ++ +D +
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 283 LQVQELTDLLKSKNEEDDPIMVAVNAK--VEEWKLILSSKDDEI-----IEYQQMLHNLR 335
Q+ L E +A+ +E L SK E+ +++ + L
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 336 EKLKNA--QLDADKSNVMALQQGIQERDSQIKMLTEQVE-------QYTKEMEKNTCIIE 386
K+ Q++ + A + ++++D ++K + QVE QY ++ EK ++
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1887
Query: 387 DLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAR 435
LK +L+ + S K+Q LD E + R ++ R
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 76.6 bits (187), Expect = 3e-13
Identities = 104/448 (23%), Positives = 199/448 (44%), Gaps = 47/448 (10%)
Query: 2040 TYSKPSISGIESDDHCQ-REQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKE 2098
T KP + ++ Q +E ELQK + ELK +LEQ + L KN +++ +
Sbjct: 846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQ 904
Query: 2099 MCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGIL 2158
L E E++ +L + ELE+ + M+ +E+ + +QL+ A
Sbjct: 905 AETELYAEAEEMRVRLAAKK---------QELEEILHEMEARLEEEEDRGQQLQ-AERKK 954
Query: 2159 TSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIA----ENERLRKELK 2214
+++M ++E++ E+ +A +KL+ + E+K K E I +N +L KE K
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLE-----KVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 2215 K--------ETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSW 2266
T+ AE+ AKN L L K + E RL+ E +LE
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEK------ 1062
Query: 2267 KSIVVTRMYETKLKELETDIAKKNQSITDLK-QLVKEATEREQKVNKYNEDLEQQIKILK 2325
+ R E + IA I +LK QL K+ E + + + ++++ Q+ LK
Sbjct: 1063 ----LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118
Query: 2326 HVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKD--QSGAESTIPDADQLKE 2383
+ E L+ +L R A ++ +K+K +L ++EA K + +ST + +
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1178
Query: 2384 KIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEE 2443
+ +++ K D E + + ++++++++ E++E K K + KN ++
Sbjct: 1179 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK-RAKANLDKN---KQ 1234
Query: 2444 KVKKLSEQLGVELTSPVAASEEFEDEEE 2471
++K + L EL A +E E +++
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKK 1262
Score = 50.8 bits (120), Expect = 2e-05
Identities = 54/226 (23%), Positives = 106/226 (46%), Gaps = 37/226 (16%)
Query: 21 QEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSL------MKMKAQEVELALEEVE 74
+EELA+ L SLS N L+ EK+ + ++ + L M+ + V A ++ E
Sbjct: 1717 KEELAEELASSLSGR--NALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 75 KAGEEQA--------------KFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQL 120
+ E A + E Q K KL +E+E A +S L +I QL
Sbjct: 1775 QLSNELATERSTAQKNESARQQLERQNKELRSKL-HEMEGAVKSKFKSTIAALEAKIAQL 1833
Query: 121 EKQLEQ--------------KDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRREN 166
E+Q+EQ KD++L+++ ++E E+K+ EQ + E+ +L+R+
Sbjct: 1834 EEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL 1893
Query: 167 KRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKN 212
+ +++++++ + Q+++D E+ + E + +S+L + N
Sbjct: 1894 EEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 172 bits (436), Expect = 4e-42
Identities = 267/1214 (21%), Positives = 515/1214 (42%), Gaps = 172/1214 (14%)
Query: 701 LKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVF 760
++A+ D+L E ++ E ++ +SQ + NL + L+ ET L ++E V
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR- 919
Query: 761 KGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQS 820
+ ++ + L +L E+E + ++ ++ L+ +K A QQ
Sbjct: 920 ----------------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA----QQM 959
Query: 821 LLYKEYLSEKETWKT----ESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNA----LQMDS 872
L +E L E+E + E T + + +KLED++ + + + NN L+ L+
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI----LVMDDQNNKLSKERKLLEERI 1015
Query: 873 DEMKKILAENSRK---ITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVC 929
++ LAE K +T L+ +S+I + ++ E + R+E EK K +L ++
Sbjct: 1016 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 930 EKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI------LQKD 983
E+I LQ ++A K+ +K + +L+ L+ Q N K R++ LQ+D
Sbjct: 1076 EQIADLQA--QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 984 NMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKA 1043
L + E + L E++E++ ELE T + T +QE + E +
Sbjct: 1134 --LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-----QQELRAKREQEVTVL 1186
Query: 1044 KKSITNSDIVSISKKITMLEMKELNER------QRAEHCQKMYEHLRTSLKQMEERNFEL 1097
KK++ D + S + + EM++ + + ++ E ++ +L + + +E+ N +L
Sbjct: 1187 KKAL---DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243
Query: 1098 ETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLRE 1157
+ L + + + ++ L ++ + SK SD +R R EL +V KL+
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKC-SDGERARA--------ELNDKVHKLQN 1294
Query: 1158 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA 1217
+ + + K+V SL QL D Q +L Q +L+ +T
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ----------ELLQEETRQKLNVSTK 1344
Query: 1218 LGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSL---RRQF 1274
L +LE + LQ + +Q L+ L + + + + T+++L +++F
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 1275 SGALP-LAQQ--------EKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKL 1325
+ L QQ +K KT +LQ + ++ ++ N +Q N+E K + + L
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 1326 KGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNR---ELVKDKEEIKYLNNII-SE 1381
+ + S D + + + E + L L R E ++ KEE++ N ++ +E
Sbjct: 1465 AEEKNISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAE 1519
Query: 1382 YERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGS 1441
E +SS ++ V +N HE LE+ + Q E+ ++ E+ +
Sbjct: 1520 MEDLVSSKDD--VGKN-VHE------------LEKSKRALETQMEEMKTQLEELEDELQA 1564
Query: 1442 IPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKV 1501
D L +LE+ ++ +K L+ R + EEK ++ + L E +
Sbjct: 1565 TEDAKL----RLEVNMQALKGQFERDLQARD--EQNEEKRRQLQRQLHEYETELE----- 1613
Query: 1502 INELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQR 1561
+E + R A A ++KL +L K++E ++ +K + I +L + + +K +QR
Sbjct: 1614 -DERKQRALAAAAKKKLEGDL--KDLELQADSAIKGREEAIK----QLRKLQAQMKDFQR 1666
Query: 1562 LLEKAREEQREI---VKKHEEDLHILHHRL-ELQADSSLNKFKQTAWDLMKQSPTPVPTN 1617
LE AR + EI K++E+ L L +LQ D + + + DL
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL----------- 1715
Query: 1618 KHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHE 1677
E E+ E SLS + QD +R+ E QL+E E
Sbjct: 1716 -------EKEELAEELASSLSG-----RNALQDEKRRLEARIA----------QLEEELE 1753
Query: 1678 DEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALK 1737
+E ++A + ++ Q+++ S L +E ++ S +N + L+S+L
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN--KELRSKLHEM 1811
Query: 1738 EKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNEN 1797
E K+ ++ + A EE++ +K+A + D+ +E+ QVED +
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1871
Query: 1798 LLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRL 1857
+ KE + R L L + E Q+ K+ RE +E + N+ + R++ L
Sbjct: 1872 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1931
Query: 1858 TSGLQGKPLTDNKQ 1871
S L+G P + Q
Sbjct: 1932 KSKLRGPPPQETSQ 1945
Score = 169 bits (429), Expect = 2e-41
Identities = 236/1189 (19%), Positives = 506/1189 (42%), Gaps = 113/1189 (9%)
Query: 1244 EKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQE 1303
+++Q L ++ RN A +L+ R F+ PL Q + + M +++ K +
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 874
Query: 1304 MKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQEL--KL 1361
+ ++ E + +E K ++ + L+E + + + + + ++ L+E+ ++
Sbjct: 875 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934
Query: 1362 NRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREV---DLERQL 1418
L ++++ + L + + + LEE++ ++ ++ Q+ E LE ++
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 994
Query: 1419 DIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIA--LRKIK-ENIRIILETRATCK 1475
+ D Q N++ + EE I D + L + E A L K+K ++ +I E K
Sbjct: 995 LVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1051
Query: 1476 SLEEKLKEKESALRLAEQNILSRDKVINELR-----LRLPATAEREKLIAELGRKEMEPK 1530
E+ +E E R E + + I +L+ L++ + E+L A L R + E
Sbjct: 1052 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1111
Query: 1531 SHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 1590
+ A + I ++ ++ +E L + KA +++R++ E+L L LE
Sbjct: 1112 QKNN---ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL----GEELEALKTELED 1164
Query: 1591 QADSSLN----KFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKK 1646
DS+ + K+ + + T H ++ EM Q A+ + L+ L + K+
Sbjct: 1165 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1224
Query: 1647 VSQDLERQREITELKVKEFE---NIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQC 1703
+L++ ++ E + + + Q ++ E + KK++A+V++L+ ++
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 1704 LKSELQAQKEANSRAPTTTMRNLVE-----------RLKSQLALKEKQQKALSRALLELR 1752
L ++ K N T M N E L SQL ++ + +R L +
Sbjct: 1285 LNDKV--HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342
Query: 1753 AEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRE 1812
++ EER S Q + + +Q ++RH L Q+ D + L ++ + +
Sbjct: 1343 TKLRQLEEER-NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1401
Query: 1813 NSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQS 1872
+ +L + ++K AY+K+ + K + QE D+L + DN++
Sbjct: 1402 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL-------------DNQRQ 1448
Query: 1873 LIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEK 1932
L+ L++K +K + QL + + + K E++ E R E+ K + + L+ K
Sbjct: 1449 LVSNLEKKQRKFD-QLLAEEKNISSKYADERDRAEAEAR-EKETKALSLARALEEALEAK 1506
Query: 1933 EGEVFTLTKQLNT-LKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKK 1991
E E+ K L ++DL + D + K+ + L + E + +LEEL+
Sbjct: 1507 E-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS-----KRALETQMEEMKTQLEELED 1560
Query: 1992 RNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIES 2051
E+ L + + + DL ++ +EK L++Q + E+
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE----------YET 1610
Query: 2052 DDHCQREQE----LQKENLKLSSENIELKFQ-----LEQANKDLPRLKNQVRDLKEMCEF 2102
+ +R+Q K+ L+ +++EL+ E+A K L +L+ Q++D + E
Sbjct: 1611 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 2103 LKKEKAEVQRKLGHVRGSGRSGKT-IPELEKTIGLMKKVVEKVQRENEQLKKASGILTSE 2161
+ + E+ +S + + +L++ + ++ ++ E E+L + S
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 2162 KMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAE 2221
+ A ++ E +L+A + +L+ L + + E+ + K + E+L EL E A+
Sbjct: 1731 RNA-LQDEKRRLEARIAQLEEELEEEQG-NMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 2222 KLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKE 2281
K A+ LE N+++ +L E +EGA +KS + E K+ +
Sbjct: 1789 KNESARQQLERQNKELRSKLHE--------------MEGAVKSKFKSTIAA--LEAKIAQ 1832
Query: 2282 LETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQG----L 2337
LE + Q + + K ++++K+ + +E + K+ + E AE L
Sbjct: 1833 LEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889
Query: 2338 KRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIK 2386
KR+L+ + +++ + +L Q E ++ E+ + + LK K++
Sbjct: 1890 KRQLEEAEEESQRINANRRKL--QRELDEATESNEAMGREVNALKSKLR 1936
Score = 152 bits (384), Expect = 4e-36
Identities = 256/1167 (21%), Positives = 487/1167 (41%), Gaps = 182/1167 (15%)
Query: 51 LFRITQSLMKMKAQEVELAL--EEVEKAGEEQAKFENQLKT---KVMKLENELEMAQQSA 105
LF + L+++ QE E+ +E++K E Q K EN+LK K +L E + Q+
Sbjct: 844 LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 903
Query: 106 GGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRE 165
+ E ++ +L K +ELE++ E+E R EE E+ +L+ E
Sbjct: 904 QAETELYAEAE--EMRVRLAAKKQELEEILHEMEA----------RLEEEEDRGQQLQAE 951
Query: 166 NKRLKKK----NEQLCQDIIDYQK-QIDSQKETLLSRRGEDS-----DYRSQLSKKNYEL 215
K++ ++ EQL ++ QK Q++ ++ ED D ++LSK+ L
Sbjct: 952 RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1011
Query: 216 IQYLDEIQT-LTEANEKIE------------VQNQEMR-KNLEESVQEMEKM-------- 253
+ + ++ T L E EK + + E+R K E+S QE+EK+
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071
Query: 254 TDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKN----------------E 297
+D + ++ + Q + QL K+ + Q + L D + KN +
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 298 EDDPIMVAVNAKVEEWKLILSSKDDEI----------IEYQQMLHNLREK----LKNAQL 343
ED A K E+ K L + + + QQ L RE+ LK A
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191
Query: 344 DADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQ 403
+ +S+ +Q+ Q+ ++ LTEQ+EQ+ + K L +NK TL +
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR-----------AKANLDKNK--QTLEK 1238
Query: 404 QTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVV 463
+ + + L +L + +E E + EA +E + + + + V+ L++ V
Sbjct: 1239 E-NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1297
Query: 464 EIKNCKNQIKIRDREIEILTKEINKLELKISDFLD-ENEALRERVGLEPKTMIDLTEFRN 522
+ N+ + + + L K++ L ++ D + E R+++ + K + L E RN
Sbjct: 1298 SVTGMLNEAEGKAIK---LAKDVASLSSQLQDTQELLQEETRQKLNVSTK-LRQLEEERN 1353
Query: 523 SKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQ-----ERGKRSATSGLTTEDL 577
S + + Q L + I +L + D KKK++ A E GK+ +
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI----- 1408
Query: 578 NLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIA---KFQ 634
EN++Q D L ++KN L +EL + DL+ R +++ K Q
Sbjct: 1409 ---ENLTQQYEEKAAAYDKLE-------KTKNR-LQQELDDLVVDLDNQRQLVSNLEKKQ 1457
Query: 635 NKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLER-LVNAIESKNAEG 693
K +L+ E K + A + + + + + ET + SL R L A+E+K E
Sbjct: 1458 RKFDQLLAEEKNISS-----KYADERDRAEAEAREKETKAL--SLARALEEALEAK--EE 1508
Query: 694 IFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQS 753
+ + LKA+++ L +++ + + E K Q+ + +++ LE E L+ +
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE---LQAT 1565
Query: 754 EGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFA 813
E + + + ++ + ++ L E E+K + L+ L +Y +
Sbjct: 1566 EDAKLRLE------------VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Query: 814 VIRHQQSL---LYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQM 870
R Q++L K+ + + + ++ + + + + Q+++ ++K++ L +
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1673
Query: 871 DSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCE 930
DE+ EN +K L E L++ L ER RK+ + +K EL A
Sbjct: 1674 SRDEIFATAKENEKKAKSL---EADLMQLQEDLAAAER-ARKQADLEKEELAEELASSLS 1729
Query: 931 KIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRT 990
LQ K +IA L++ ELE ++ + R Q+ L
Sbjct: 1730 GRNALQDEKRRLEARIAQLEE---------ELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780
Query: 991 SNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETK------------LGNES 1038
+ +N S ++Q+E NKEL + KLH +E A + + K L +
Sbjct: 1781 ATERSTAQKNESARQQLERQNKEL---RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1837
Query: 1039 SMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1098
+ +K + KK+ + ++ +ER+ AE ++ E +KQ++ +LE
Sbjct: 1838 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR---QLE 1894
Query: 1099 TKFAELTKINLDAQKVEQMLRDELADS 1125
E +IN + +K+++ L DE +S
Sbjct: 1895 EAEEESQRINANRRKLQREL-DEATES 1920
Score = 149 bits (377), Expect = 3e-35
Identities = 226/1016 (22%), Positives = 429/1016 (42%), Gaps = 162/1016 (15%)
Query: 1542 IANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHE---EDLHILHHRL----ELQADS 1594
+ + + KE+ L+K + +KA E +E+ +KH E+ ++L +L EL A++
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 1595 SLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQ---DL 1651
+ + A KQ + L EME + E++D L + KK++Q DL
Sbjct: 914 EEMRVRLAA---KKQELEEI--------LHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 1652 ERQREITELKVKEFENIKLQLQE-NHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQA 1710
E Q L+ +E KLQL++ E ++KK++ E+ + ++ KE + L+ +
Sbjct: 963 EEQ-----LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017
Query: 1711 QKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQK 1770
TT + E+ K+ LK K + +S + L+ E + E + +
Sbjct: 1018 L--------TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1069
Query: 1771 EAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQ 1830
+A +QI D L+ Q+ +L L K +E L+ + R L D + NN L+K +
Sbjct: 1070 DASDFHEQIAD-----LQAQIAELKMQLAKKEEELQAALAR---LDDEIAQKNNALKKIR 1121
Query: 1831 KAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEG 1890
+ I +E++D E + K+ K+ L EEL+ +LE+ L+
Sbjct: 1122 ELEGHISDLQEDLDSERAARNKAEKQ-------------KRDLGEELEALKTELEDTLDS 1168
Query: 1891 KVEEVDLKPMKEKNA---KEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLK 1947
+ +L+ +E+ K+ L EE + +A+++ +R K + E LT+QL K
Sbjct: 1169 TATQQELRAKREQEVTVLKKALD--EETRSHEAQVQEMRQKHAQAVEE---LTEQLEQFK 1223
Query: 1948 DLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQ 2007
A DK K TL+++ D +R L K+ E KK+ L+ + L +
Sbjct: 1224 RAKANLDKNKQTLEKE------NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277
Query: 2008 A-LPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENL 2066
R + + +H ++ L + K ++ + S Q QEL +E
Sbjct: 1278 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ--LQDTQELLQEET 1335
Query: 2067 KLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKT 2126
+ + + + +L Q ++ L++Q+ + E + L++ + + +L S K
Sbjct: 1336 R---QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD------SKKK 1386
Query: 2127 IPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMA---NIEQENEKLKAELEKLKAH 2183
+ + T+ +++ ++ Q+E E L + EK A +E+ +L+ EL+ L
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQY----EEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 2184 LGHQ--LSMHYESKTKGTEKIIAENERLRKELKKETDAAE------------------KL 2223
L +Q L + E K + ++++AE + + + E D AE +
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1502
Query: 2224 RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYE--TKLKE 2281
AK LE N+ + ++E+ +LE + K + T+M E T+L+E
Sbjct: 1503 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS-----KRALETQMEEMKTQLEE 1557
Query: 2282 LETDIAKKNQSITDLK---QLVKEATERE-QKVNKYNEDLEQQIKILKHVPE-------- 2329
LE ++ + L+ Q +K ER+ Q ++ NE+ +Q++ H E
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617
Query: 2330 ----GAETEQGLKRELQVLRLANHQLDKEKAELIHQIE---------------------- 2363
A ++ L+ +L+ L L K + E I Q+
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE 1677
Query: 2364 ----ANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKL---KKELENF 2416
A +++ A+S D QL+E + E K +DLEK+ L EE+ + L++
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1737
Query: 2417 DPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEES 2472
I L+ +EE + ++V+K ++Q +L++ +A + ES
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ-AEQLSNELATERSTAQKNES 1792
Score = 140 bits (354), Expect = 1e-32
Identities = 212/1046 (20%), Positives = 435/1046 (41%), Gaps = 86/1046 (8%)
Query: 39 ELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL 98
E + E++E+ + + M + ++E LEE E A ++ + + K+ KLE+E+
Sbjct: 935 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 994
Query: 99 EMA--QQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAE 156
+ Q + ++ + L I L L +++ + +++ K K + + +L +R ++ E
Sbjct: 995 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1054
Query: 157 NENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELI 216
+L + ++L+ + I D Q QI K L + + + ++ L++ + E+
Sbjct: 1055 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK---EEELQAALARLDDEIA 1111
Query: 217 QYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKK 276
Q + ++ + E I +++ + ++ D ++A+ + ++ +D
Sbjct: 1112 QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1171
Query: 277 ENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLRE 336
+ + + QE+T L K+ +EE + A+V+E + + +E+ E + +
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETR----SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227
Query: 337 KLKNAQLDADKSN------VMALQQGIQERDSQIKMLTEQVEQYTKEM---EKNTCIIED 387
L + +K N + L Q QE + + K L QV++ + E+ + D
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1287
Query: 388 ----LKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVE 443
L+NE++ G ++ +K+ + L + ++ T EL + + R+K +
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD---TQELLQEETRQK----LN 1340
Query: 444 ALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEAL 503
+L+ E L+D + E K + +R I L +++ + K+ DF EAL
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLSDSKKKLQDFASTVEAL 1397
Query: 504 RERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQER 563
E K + +LT+ K + L +E++ L +DL + + ++
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV---VDLDNQRQLVSNLE 1454
Query: 564 GKRSATSGLTTEDLNLTENIS-QGDRIS----ERKLDLLS----LKNMSEAQSKNEFLSR 614
K+ L E+ N++ + + DR E++ LS L+ EA+ + E ++
Sbjct: 1455 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 615 ELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSL 674
L + DL S+ + K + EL + + LE M+E+ ++E+ E L
Sbjct: 1515 MLKAEMEDLVSSKDDVGK---NVHELEKSKRALETQMEEMKTQLEEL---------EDEL 1562
Query: 675 IIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQ-- 732
+L + + +G F+ L+A+ +Q + +L+++L E E + +Q
Sbjct: 1563 QATEDAKLRLEVNMQALKGQFERD--LQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1620
Query: 733 ---LAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQ 789
AK L+ D + E +G K + + +
Sbjct: 1621 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA 1680
Query: 790 ELENKEKKLKNLEDSLEDYNRKFAVIR--HQQSLLYKEYLSEKETWKTESK-TIKEEKRK 846
+ EKK K+LE L A +Q+ L KE L+E+ + +++EKR+
Sbjct: 1681 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 847 LEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVEL 906
LE ++ Q +++E + A+ SD ++K + + L + + + +L
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAM---SDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797
Query: 907 ERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELAN 966
ERQ N++ +++L ME V K E KIA L++ V+ E + A
Sbjct: 1798 ERQ----NKELRSKLHEMEGAVKSKFKSTIAALEA---KIAQLEEQVEQEA--REKQAAT 1848
Query: 967 KQYNELTAKYRDIL----QKDNMLVQRTSNLEHLECENISLKEQVESINKE---LEITKE 1019
K + K ++IL + M Q E LK Q+E +E + +
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908
Query: 1020 KL-HTIEQAWEQETKLGNESSMDKAK 1044
KL +++A E +G E + K+K
Sbjct: 1909 KLQRELDEATESNEAMGREVNALKSK 1934
Score = 130 bits (328), Expect = 1e-29
Identities = 214/985 (21%), Positives = 407/985 (41%), Gaps = 150/985 (15%)
Query: 17 DLPRQEELADNLL-------ISLSKVEVNELKSEKQENVIHLFR---------ITQSLMK 60
+L +EE A NL +S++EV K EK + + + +
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 61 MKAQEVELALEEVEKAGEEQAKF---------ENQLKTKVMKLENELEMAQQSAGGRDTR 111
++AQ EL ++ +K E QA +N K+ +LE + Q+ R
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE--R 1138
Query: 112 FLRNEICQLEKQLEQKDRELEDMEKELE----KEKKVNEQLALRNEEAENENSKLRRENK 167
RN+ EKQ ELE ++ ELE E A R +E L E +
Sbjct: 1139 AARNKA---EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1195
Query: 168 RLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTE 227
+ + +++ Q +++ Q E + + L K+N +L E++ L +
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA---GELRVLGQ 1252
Query: 228 ANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAI----VHQTDNVID----------- 272
A +++E +K LE VQE++ + R +A VH+ N ++
Sbjct: 1253 AKQEVE----HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308
Query: 273 ---QLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQ 329
+L K+ Q+Q+ +LL+ + + + V+ K+ + + +S D++ E +
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQK----LNVSTKLRQLEEERNSLQDQLDEEME 1364
Query: 330 MLHNLREKLK--NAQLDADK-------SNVMALQQGIQERDSQIKMLTEQVEQYTKEMEK 380
NL + N QL K S V AL++G + +I+ LT+Q E+ +K
Sbjct: 1365 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Query: 381 NTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLD--------ILKEKTKEAERTAE---L 429
+E KN LQ+ + ++ S L+ +L E+ + + A+
Sbjct: 1425 ----LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1480
Query: 430 AEADAREKD-------KELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIE-- 480
AEA+AREK+ + L EAL+ ++ E L+ + ++ + K+ + E+E
Sbjct: 1481 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1540
Query: 481 --ILTKEINKLELKISDFLDENEALRE-RVGLEPKTMIDLTEFRNSKHLKQQQYRAENQI 537
L ++ +++ ++ + DE +A + ++ LE +F + +Q + +
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600
Query: 538 LLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLL 597
L +++ E E D +K+ A + K +DL L Q D + + +
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGD----LKDLEL-----QADSAIKGREE-- 1649
Query: 598 SLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQA 657
++K + + Q++ + REL + + + + K K L + QL+E L A
Sbjct: 1650 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED----LAA 1705
Query: 658 IKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQ 717
+ +K D++ E + E L +++ +NA + D L+A++ QL EEL +
Sbjct: 1706 AERARKQADLEKEELA------EELASSLSGRNA--LQDEKRRLEARIAQL---EEELEE 1754
Query: 718 ELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASII 777
E + EA+ S ++ KA + + L E + R + N S+ +
Sbjct: 1755 E--QGNMEAM--SDRVRKATQQAEQLSNELATERSTAQKN-------------ESARQQL 1797
Query: 778 NSQNEYLIHLLQELENKEK-KLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTE 836
QN+ L L E+E K K K+ +LE K A + Q +E + ++ K +
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALE---AKIAQLEEQVEQEAREKQAATKSLKQK 1854
Query: 837 SKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSL 896
K +KE ++ED+ ++ A + KE NA ++K+ L E + + N + L
Sbjct: 1855 DKKLKEILLQVEDE-RKMAEQYKEQAEKGNARVK---QLKRQLEEAEEESQRINANRRKL 1910
Query: 897 IRQYTTLVELERQLRKENEKQKNEL 921
R+ E + +E K++L
Sbjct: 1911 QRELDEATESNEAMGREVNALKSKL 1935
Score = 120 bits (301), Expect = 2e-26
Identities = 193/835 (23%), Positives = 351/835 (42%), Gaps = 131/835 (15%)
Query: 1646 KVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLK 1705
KV L+ R+ E++ KE E LQ+ E + +K + E+++L+ Q +E L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDE-----LQKTKERQ-QKAENELKELEQKHSQLTEEKNLLQ 900
Query: 1706 SELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIIS 1765
+LQA+ E + A E ++ +LA K+++ L L E+ A + EE
Sbjct: 901 EQLQAETELYAEA---------EEMRVRLAAKKQE---LEEILHEMEARLE---EEEDRG 945
Query: 1766 ATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNL---NDL 1822
Q E QQ++D L+ Q+E+ KL+ T++ + L D + +D
Sbjct: 946 QQLQAERKKMAQQMLD-----LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 1000
Query: 1823 NNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVK 1882
NN+L K++K L+ +I LT+ L + EE + +
Sbjct: 1001 NNKLSKERKL-----------------LEERISDLTTNLAEE----------EEKAKNLT 1033
Query: 1883 KLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQ 1942
KL+N+ E + E++++ KE+ +++EL +K + K+EG + E ++ L Q
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDASDFHE---QIADLQAQ 1084
Query: 1943 LNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILY 2002
+ LK AK ++E +L + L K++ EL+ DL+ D+
Sbjct: 1085 IAELKMQLAKKEEELQAALARLDDEIAQKNNAL--------KKIRELEGHISDLQEDLDS 1136
Query: 2003 MRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQ 2062
RA + Q R L E+L AL+ + +DT + + + +REQE+
Sbjct: 1137 ERAAR--------NKAEKQKRDLGEELEALKTEL-EDTLDS---TATQQELRAKREQEVT 1184
Query: 2063 KENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGR 2122
L E + Q+++ + + V +L E E K+ KA + +
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQ---KHAQAVEELTEQLEQFKRAKANLDK---------- 1231
Query: 2123 SGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKA 2182
+ +T+ + + +V+ + ++E E KK E + + E+ +AEL
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS-DGERARAELNDKV- 1289
Query: 2183 HLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLE 2242
H+L ES T NE K +K D A ++ E+L E+ +L
Sbjct: 1290 ---HKLQNEVESVTGML------NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1340
Query: 2243 ETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKE 2302
+ K Q E R + D + + + E + L ++ + + D V+
Sbjct: 1341 VSTKLRQLEEERNSLQDQLDEE----MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1396
Query: 2303 ATEREQKVNKYNEDLEQQIKILKHVPEGAE-TEQGLKRELQVLRLANHQLDKEKAELIHQ 2361
E +++ K E+L QQ + + E T+ L++EL L + LD ++ +L+
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV---DLDNQR-QLVSN 1452
Query: 2362 IEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQ-------HLKEEIKKLKKELE 2414
+E K Q + + + + K D + + EK+ EE + K+ELE
Sbjct: 1453 LE--KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1510
Query: 2415 NFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDE 2469
+ E+EDL + K++V KN+ EK K+ E E+ + + EE EDE
Sbjct: 1511 RTNKMLKAEMEDL-VSSKDDVGKNVHELEKSKRALETQMEEMKTQL---EELEDE 1561
Score = 82.4 bits (202), Expect = 5e-15
Identities = 98/469 (20%), Positives = 199/469 (42%), Gaps = 38/469 (8%)
Query: 4 NINWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKA 63
NI+ K + D + +E+ L ++ + E E K E + L + L+ K
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK- 1527
Query: 64 QEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL----------EMAQQSAGGRDTRFL 113
+V + E+EK+ ++KT++ +LE+EL E+ Q+ G+ R L
Sbjct: 1528 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1587
Query: 114 RNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKN 173
+ Q E++ Q R+L + E ELE E+K A ++ E + L + K
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1647
Query: 174 EQLCQDIIDYQKQI-DSQKETLLSRRGEDSDY----RSQLSKKNYE--LIQYLDEIQTLT 226
E+ + + Q Q+ D Q+E +R D + ++ K+ E L+Q +++
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1707
Query: 227 EANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQ----LKKENDHYQ 282
A ++ +++ +E+ + L S+ + DE R++A + Q + +++ ++ +D +
Sbjct: 1708 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1767
Query: 283 LQVQELTDLLKSKNEEDDPIMVAVNAK--VEEWKLILSSKDDEI-----IEYQQMLHNLR 335
Q+ L E +A+ +E L SK E+ +++ + L
Sbjct: 1768 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1827
Query: 336 EKLKNA--QLDADKSNVMALQQGIQERDSQIKMLTEQVE-------QYTKEMEKNTCIIE 386
K+ Q++ + A + ++++D ++K + QVE QY ++ EK ++
Sbjct: 1828 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1887
Query: 387 DLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAR 435
LK +L+ + S K+Q LD E + R ++ R
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1936
Score = 76.6 bits (187), Expect = 3e-13
Identities = 104/448 (23%), Positives = 199/448 (44%), Gaps = 47/448 (10%)
Query: 2040 TYSKPSISGIESDDHCQ-REQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKE 2098
T KP + ++ Q +E ELQK + ELK +LEQ + L KN +++ +
Sbjct: 846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQ 904
Query: 2099 MCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGIL 2158
L E E++ +L + ELE+ + M+ +E+ + +QL+ A
Sbjct: 905 AETELYAEAEEMRVRLAAKK---------QELEEILHEMEARLEEEEDRGQQLQ-AERKK 954
Query: 2159 TSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIA----ENERLRKELK 2214
+++M ++E++ E+ +A +KL+ + E+K K E I +N +L KE K
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLE-----KVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 2215 K--------ETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSW 2266
T+ AE+ AKN L L K + E RL+ E +LE
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEK------ 1062
Query: 2267 KSIVVTRMYETKLKELETDIAKKNQSITDLK-QLVKEATEREQKVNKYNEDLEQQIKILK 2325
+ R E + IA I +LK QL K+ E + + + ++++ Q+ LK
Sbjct: 1063 ----LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118
Query: 2326 HVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKD--QSGAESTIPDADQLKE 2383
+ E L+ +L R A ++ +K+K +L ++EA K + +ST + +
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1178
Query: 2384 KIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEE 2443
+ +++ K D E + + ++++++++ E++E K K + KN ++
Sbjct: 1179 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK-RAKANLDKN---KQ 1234
Query: 2444 KVKKLSEQLGVELTSPVAASEEFEDEEE 2471
++K + L EL A +E E +++
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKK 1262
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 172 bits (436), Expect = 4e-42
Identities = 267/1214 (21%), Positives = 515/1214 (42%), Gaps = 172/1214 (14%)
Query: 701 LKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVF 760
++A+ D+L E ++ E ++ +SQ + NL + L+ ET L ++E V
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR- 912
Query: 761 KGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQS 820
+ ++ + L +L E+E + ++ ++ L+ +K A QQ
Sbjct: 913 ----------------LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMA----QQM 952
Query: 821 LLYKEYLSEKETWKT----ESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNA----LQMDS 872
L +E L E+E + E T + + +KLED++ + + + NN L+ L+
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI----LVMDDQNNKLSKERKLLEERI 1008
Query: 873 DEMKKILAENSRK---ITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVC 929
++ LAE K +T L+ +S+I + ++ E + R+E EK K +L ++
Sbjct: 1009 SDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 930 EKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI------LQKD 983
E+I LQ ++A K+ +K + +L+ L+ Q N K R++ LQ+D
Sbjct: 1069 EQIADLQA--QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 984 NMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKA 1043
L + E + L E++E++ ELE T + T +QE + E +
Sbjct: 1127 --LDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT-----QQELRAKREQEVTVL 1179
Query: 1044 KKSITNSDIVSISKKITMLEMKELNER------QRAEHCQKMYEHLRTSLKQMEERNFEL 1097
KK++ D + S + + EM++ + + ++ E ++ +L + + +E+ N +L
Sbjct: 1180 KKAL---DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236
Query: 1098 ETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLRE 1157
+ L + + + ++ L ++ + SK SD +R R EL +V KL+
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKC-SDGERARA--------ELNDKVHKLQN 1287
Query: 1158 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA 1217
+ + + K+V SL QL D Q +L Q +L+ +T
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ----------ELLQEETRQKLNVSTK 1337
Query: 1218 LGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSL---RRQF 1274
L +LE + LQ + +Q L+ L + + + + T+++L +++F
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 1275 SGALP-LAQQ--------EKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKL 1325
+ L QQ +K KT +LQ + ++ ++ N +Q N+E K + + L
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 1326 KGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNR---ELVKDKEEIKYLNNII-SE 1381
+ + S D + + + E + L L R E ++ KEE++ N ++ +E
Sbjct: 1458 AEEKNISSKYADERDRAEA-----EAREKETKALSLARALEEALEAKEELERTNKMLKAE 1512
Query: 1382 YERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGS 1441
E +SS ++ V +N HE LE+ + Q E+ ++ E+ +
Sbjct: 1513 MEDLVSSKDD--VGKN-VHE------------LEKSKRALETQMEEMKTQLEELEDELQA 1557
Query: 1442 IPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKV 1501
D L +LE+ ++ +K L+ R + EEK ++ + L E +
Sbjct: 1558 TEDAKL----RLEVNMQALKGQFERDLQARD--EQNEEKRRQLQRQLHEYETELE----- 1606
Query: 1502 INELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQR 1561
+E + R A A ++KL +L K++E ++ +K + I +L + + +K +QR
Sbjct: 1607 -DERKQRALAAAAKKKLEGDL--KDLELQADSAIKGREEAIK----QLRKLQAQMKDFQR 1659
Query: 1562 LLEKAREEQREI---VKKHEEDLHILHHRL-ELQADSSLNKFKQTAWDLMKQSPTPVPTN 1617
LE AR + EI K++E+ L L +LQ D + + + DL
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL----------- 1708
Query: 1618 KHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHE 1677
E E+ E SLS + QD +R+ E QL+E E
Sbjct: 1709 -------EKEELAEELASSLSG-----RNALQDEKRRLEARIA----------QLEEELE 1746
Query: 1678 DEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALK 1737
+E ++A + ++ Q+++ S L +E ++ S +N + L+S+L
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQN--KELRSKLHEM 1804
Query: 1738 EKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNEN 1797
E K+ ++ + A EE++ +K+A + D+ +E+ QVED +
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKM 1864
Query: 1798 LLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRL 1857
+ KE + R L L + E Q+ K+ RE +E + N+ + R++ L
Sbjct: 1865 AEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1924
Query: 1858 TSGLQGKPLTDNKQ 1871
S L+G P + Q
Sbjct: 1925 KSKLRGPPPQETSQ 1938
Score = 169 bits (429), Expect = 2e-41
Identities = 236/1189 (19%), Positives = 506/1189 (42%), Gaps = 113/1189 (9%)
Query: 1244 EKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQE 1303
+++Q L ++ RN A +L+ R F+ PL Q + + M +++ K +
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKER 867
Query: 1304 MKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQEL--KL 1361
+ ++ E + +E K ++ + L+E + + + + + ++ L+E+ ++
Sbjct: 868 QQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 927
Query: 1362 NRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREV---DLERQL 1418
L ++++ + L + + + LEE++ ++ ++ Q+ E LE ++
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 987
Query: 1419 DIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIA--LRKIK-ENIRIILETRATCK 1475
+ D Q N++ + EE I D + L + E A L K+K ++ +I E K
Sbjct: 988 LVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLK 1044
Query: 1476 SLEEKLKEKESALRLAEQNILSRDKVINELR-----LRLPATAEREKLIAELGRKEMEPK 1530
E+ +E E R E + + I +L+ L++ + E+L A L R + E
Sbjct: 1045 KEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA 1104
Query: 1531 SHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 1590
+ A + I ++ ++ +E L + KA +++R++ E+L L LE
Sbjct: 1105 QKNN---ALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL----GEELEALKTELED 1157
Query: 1591 QADSSLN----KFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKK 1646
DS+ + K+ + + T H ++ EM Q A+ + L+ L + K+
Sbjct: 1158 TLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR 1217
Query: 1647 VSQDLERQREITELKVKEFE---NIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQC 1703
+L++ ++ E + + + Q ++ E + KK++A+V++L+ ++
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 1704 LKSELQAQKEANSRAPTTTMRNLVE-----------RLKSQLALKEKQQKALSRALLELR 1752
L ++ K N T M N E L SQL ++ + +R L +
Sbjct: 1278 LNDKV--HKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335
Query: 1753 AEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRE 1812
++ EER S Q + + +Q ++RH L Q+ D + L ++ + +
Sbjct: 1336 TKLRQLEEER-NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK 1394
Query: 1813 NSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQS 1872
+ +L + ++K AY+K+ + K + QE D+L + DN++
Sbjct: 1395 KRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDL-------------DNQRQ 1441
Query: 1873 LIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEK 1932
L+ L++K +K + QL + + + K E++ E R E+ K + + L+ K
Sbjct: 1442 LVSNLEKKQRKFD-QLLAEEKNISSKYADERDRAEAEAR-EKETKALSLARALEEALEAK 1499
Query: 1933 EGEVFTLTKQLNT-LKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKK 1991
E E+ K L ++DL + D + K+ + L + E + +LEEL+
Sbjct: 1500 E-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS-----KRALETQMEEMKTQLEELED 1553
Query: 1992 RNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIES 2051
E+ L + + + DL ++ +EK L++Q + E+
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHE----------YET 1603
Query: 2052 DDHCQREQE----LQKENLKLSSENIELKFQ-----LEQANKDLPRLKNQVRDLKEMCEF 2102
+ +R+Q K+ L+ +++EL+ E+A K L +L+ Q++D + E
Sbjct: 1604 ELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 2103 LKKEKAEVQRKLGHVRGSGRSGKT-IPELEKTIGLMKKVVEKVQRENEQLKKASGILTSE 2161
+ + E+ +S + + +L++ + ++ ++ E E+L + S
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 2162 KMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAE 2221
+ A ++ E +L+A + +L+ L + + E+ + K + E+L EL E A+
Sbjct: 1724 RNA-LQDEKRRLEARIAQLEEELEEEQG-NMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 2222 KLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKE 2281
K A+ LE N+++ +L E +EGA +KS + E K+ +
Sbjct: 1782 KNESARQQLERQNKELRSKLHE--------------MEGAVKSKFKSTIAA--LEAKIAQ 1825
Query: 2282 LETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQG----L 2337
LE + Q + + K ++++K+ + +E + K+ + E AE L
Sbjct: 1826 LEEQV---EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1882
Query: 2338 KRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIK 2386
KR+L+ + +++ + +L Q E ++ E+ + + LK K++
Sbjct: 1883 KRQLEEAEEESQRINANRRKL--QRELDEATESNEAMGREVNALKSKLR 1929
Score = 152 bits (384), Expect = 4e-36
Identities = 256/1167 (21%), Positives = 487/1167 (41%), Gaps = 182/1167 (15%)
Query: 51 LFRITQSLMKMKAQEVELAL--EEVEKAGEEQAKFENQLKT---KVMKLENELEMAQQSA 105
LF + L+++ QE E+ +E++K E Q K EN+LK K +L E + Q+
Sbjct: 837 LFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL 896
Query: 106 GGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRE 165
+ E ++ +L K +ELE++ E+E R EE E+ +L+ E
Sbjct: 897 QAETELYAEAE--EMRVRLAAKKQELEEILHEMEA----------RLEEEEDRGQQLQAE 944
Query: 166 NKRLKKK----NEQLCQDIIDYQK-QIDSQKETLLSRRGEDS-----DYRSQLSKKNYEL 215
K++ ++ EQL ++ QK Q++ ++ ED D ++LSK+ L
Sbjct: 945 RKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL 1004
Query: 216 IQYLDEIQT-LTEANEKIE------------VQNQEMR-KNLEESVQEMEKM-------- 253
+ + ++ T L E EK + + E+R K E+S QE+EK+
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064
Query: 254 TDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKN----------------E 297
+D + ++ + Q + QL K+ + Q + L D + KN +
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124
Query: 298 EDDPIMVAVNAKVEEWKLILSSKDDEI----------IEYQQMLHNLREK----LKNAQL 343
ED A K E+ K L + + + QQ L RE+ LK A
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184
Query: 344 DADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQ 403
+ +S+ +Q+ Q+ ++ LTEQ+EQ+ + K L +NK TL +
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKR-----------AKANLDKNK--QTLEK 1231
Query: 404 QTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVV 463
+ + + L +L + +E E + EA +E + + + + V+ L++ V
Sbjct: 1232 E-NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVE 1290
Query: 464 EIKNCKNQIKIRDREIEILTKEINKLELKISDFLD-ENEALRERVGLEPKTMIDLTEFRN 522
+ N+ + + + L K++ L ++ D + E R+++ + K + L E RN
Sbjct: 1291 SVTGMLNEAEGKAIK---LAKDVASLSSQLQDTQELLQEETRQKLNVSTK-LRQLEEERN 1346
Query: 523 SKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQ-----ERGKRSATSGLTTEDL 577
S + + Q L + I +L + D KKK++ A E GK+ +
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEI----- 1401
Query: 578 NLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIA---KFQ 634
EN++Q D L ++KN L +EL + DL+ R +++ K Q
Sbjct: 1402 ---ENLTQQYEEKAAAYDKLE-------KTKNR-LQQELDDLVVDLDNQRQLVSNLEKKQ 1450
Query: 635 NKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLER-LVNAIESKNAEG 693
K +L+ E K + A + + + + + ET + SL R L A+E+K E
Sbjct: 1451 RKFDQLLAEEKNISS-----KYADERDRAEAEAREKETKAL--SLARALEEALEAK--EE 1501
Query: 694 IFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQS 753
+ + LKA+++ L +++ + + E K Q+ + +++ LE E L+ +
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE---LQAT 1558
Query: 754 EGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFA 813
E + + + ++ + ++ L E E+K + L+ L +Y +
Sbjct: 1559 EDAKLRLE------------VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Query: 814 VIRHQQSL---LYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQM 870
R Q++L K+ + + + ++ + + + + Q+++ ++K++ L +
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666
Query: 871 DSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCE 930
DE+ EN +K L E L++ L ER RK+ + +K EL A
Sbjct: 1667 SRDEIFATAKENEKKAKSL---EADLMQLQEDLAAAER-ARKQADLEKEELAEELASSLS 1722
Query: 931 KIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRT 990
LQ K +IA L++ ELE ++ + R Q+ L
Sbjct: 1723 GRNALQDEKRRLEARIAQLEE---------ELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773
Query: 991 SNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETK------------LGNES 1038
+ +N S ++Q+E NKEL + KLH +E A + + K L +
Sbjct: 1774 ATERSTAQKNESARQQLERQNKEL---RSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQV 1830
Query: 1039 SMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1098
+ +K + KK+ + ++ +ER+ AE ++ E +KQ++ +LE
Sbjct: 1831 EQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR---QLE 1887
Query: 1099 TKFAELTKINLDAQKVEQMLRDELADS 1125
E +IN + +K+++ L DE +S
Sbjct: 1888 EAEEESQRINANRRKLQREL-DEATES 1913
Score = 149 bits (377), Expect = 3e-35
Identities = 226/1016 (22%), Positives = 429/1016 (42%), Gaps = 162/1016 (15%)
Query: 1542 IANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHE---EDLHILHHRL----ELQADS 1594
+ + + KE+ L+K + +KA E +E+ +KH E+ ++L +L EL A++
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 1595 SLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQ---DL 1651
+ + A KQ + L EME + E++D L + KK++Q DL
Sbjct: 907 EEMRVRLAA---KKQELEEI--------LHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 1652 ERQREITELKVKEFENIKLQLQE-NHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQA 1710
E Q L+ +E KLQL++ E ++KK++ E+ + ++ KE + L+ +
Sbjct: 956 EEQ-----LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010
Query: 1711 QKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQK 1770
TT + E+ K+ LK K + +S + L+ E + E + +
Sbjct: 1011 L--------TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1062
Query: 1771 EAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQ 1830
+A +QI D L+ Q+ +L L K +E L+ + R L D + NN L+K +
Sbjct: 1063 DASDFHEQIAD-----LQAQIAELKMQLAKKEEELQAALAR---LDDEIAQKNNALKKIR 1114
Query: 1831 KAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEG 1890
+ I +E++D E + K+ K+ L EEL+ +LE+ L+
Sbjct: 1115 ELEGHISDLQEDLDSERAARNKAEKQ-------------KRDLGEELEALKTELEDTLDS 1161
Query: 1891 KVEEVDLKPMKEKNA---KEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLK 1947
+ +L+ +E+ K+ L EE + +A+++ +R K + E LT+QL K
Sbjct: 1162 TATQQELRAKREQEVTVLKKALD--EETRSHEAQVQEMRQKHAQAVEE---LTEQLEQFK 1216
Query: 1948 DLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQ 2007
A DK K TL+++ D +R L K+ E KK+ L+ + L +
Sbjct: 1217 RAKANLDKNKQTLEKE------NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270
Query: 2008 A-LPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENL 2066
R + + +H ++ L + K ++ + S Q QEL +E
Sbjct: 1271 GERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ--LQDTQELLQEET 1328
Query: 2067 KLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKT 2126
+ + + + +L Q ++ L++Q+ + E + L++ + + +L S K
Sbjct: 1329 R---QKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD------SKKK 1379
Query: 2127 IPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMA---NIEQENEKLKAELEKLKAH 2183
+ + T+ +++ ++ Q+E E L + EK A +E+ +L+ EL+ L
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQY----EEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 2184 LGHQ--LSMHYESKTKGTEKIIAENERLRKELKKETDAAE------------------KL 2223
L +Q L + E K + ++++AE + + + E D AE +
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEA 1495
Query: 2224 RIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYE--TKLKE 2281
AK LE N+ + ++E+ +LE + K + T+M E T+L+E
Sbjct: 1496 LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS-----KRALETQMEEMKTQLEE 1550
Query: 2282 LETDIAKKNQSITDLK---QLVKEATERE-QKVNKYNEDLEQQIKILKHVPE-------- 2329
LE ++ + L+ Q +K ER+ Q ++ NE+ +Q++ H E
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610
Query: 2330 ----GAETEQGLKRELQVLRLANHQLDKEKAELIHQIE---------------------- 2363
A ++ L+ +L+ L L K + E I Q+
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE 1670
Query: 2364 ----ANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKL---KKELENF 2416
A +++ A+S D QL+E + E K +DLEK+ L EE+ + L++
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1730
Query: 2417 DPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEES 2472
I L+ +EE + ++V+K ++Q +L++ +A + ES
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ-AEQLSNELATERSTAQKNES 1785
Score = 140 bits (354), Expect = 1e-32
Identities = 212/1046 (20%), Positives = 435/1046 (41%), Gaps = 86/1046 (8%)
Query: 39 ELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL 98
E + E++E+ + + M + ++E LEE E A ++ + + K+ KLE+E+
Sbjct: 928 EARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEI 987
Query: 99 EMA--QQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAE 156
+ Q + ++ + L I L L +++ + +++ K K + + +L +R ++ E
Sbjct: 988 LVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE 1047
Query: 157 NENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELI 216
+L + ++L+ + I D Q QI K L + + + ++ L++ + E+
Sbjct: 1048 KSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKK---EEELQAALARLDDEIA 1104
Query: 217 QYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKK 276
Q + ++ + E I +++ + ++ D ++A+ + ++ +D
Sbjct: 1105 QKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1164
Query: 277 ENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLRE 336
+ + + QE+T L K+ +EE + A+V+E + + +E+ E + +
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETR----SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220
Query: 337 KLKNAQLDADKSN------VMALQQGIQERDSQIKMLTEQVEQYTKEM---EKNTCIIED 387
L + +K N + L Q QE + + K L QV++ + E+ + D
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELND 1280
Query: 388 ----LKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVE 443
L+NE++ G ++ +K+ + L + ++ T EL + + R+K +
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD---TQELLQEETRQK----LN 1333
Query: 444 ALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEAL 503
+L+ E L+D + E K + +R I L +++ + K+ DF EAL
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEEMEAKQNL---ERHISTLNIQLSDSKKKLQDFASTVEAL 1390
Query: 504 RERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQER 563
E K + +LT+ K + L +E++ L +DL + + ++
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV---VDLDNQRQLVSNLE 1447
Query: 564 GKRSATSGLTTEDLNLTENIS-QGDRIS----ERKLDLLS----LKNMSEAQSKNEFLSR 614
K+ L E+ N++ + + DR E++ LS L+ EA+ + E ++
Sbjct: 1448 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 615 ELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSL 674
L + DL S+ + K + EL + + LE M+E+ ++E+ E L
Sbjct: 1508 MLKAEMEDLVSSKDDVGK---NVHELEKSKRALETQMEEMKTQLEEL---------EDEL 1555
Query: 675 IIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQ-- 732
+L + + +G F+ L+A+ +Q + +L+++L E E + +Q
Sbjct: 1556 QATEDAKLRLEVNMQALKGQFERD--LQARDEQNEEKRRQLQRQLHEYETELEDERKQRA 1613
Query: 733 ---LAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQ 789
AK L+ D + E +G K + + +
Sbjct: 1614 LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA 1673
Query: 790 ELENKEKKLKNLEDSLEDYNRKFAVIR--HQQSLLYKEYLSEKETWKTESK-TIKEEKRK 846
+ EKK K+LE L A +Q+ L KE L+E+ + +++EKR+
Sbjct: 1674 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 847 LEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVEL 906
LE ++ Q +++E + A+ SD ++K + + L + + + +L
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAM---SDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790
Query: 907 ERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELAN 966
ERQ N++ +++L ME V K E KIA L++ V+ E + A
Sbjct: 1791 ERQ----NKELRSKLHEMEGAVKSKFKSTIAALEA---KIAQLEEQVEQEA--REKQAAT 1841
Query: 967 KQYNELTAKYRDIL----QKDNMLVQRTSNLEHLECENISLKEQVESINKE---LEITKE 1019
K + K ++IL + M Q E LK Q+E +E + +
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901
Query: 1020 KL-HTIEQAWEQETKLGNESSMDKAK 1044
KL +++A E +G E + K+K
Sbjct: 1902 KLQRELDEATESNEAMGREVNALKSK 1927
Score = 130 bits (328), Expect = 1e-29
Identities = 214/985 (21%), Positives = 407/985 (41%), Gaps = 150/985 (15%)
Query: 17 DLPRQEELADNLL-------ISLSKVEVNELKSEKQENVIHLFR---------ITQSLMK 60
+L +EE A NL +S++EV K EK + + + +
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073
Query: 61 MKAQEVELALEEVEKAGEEQAKF---------ENQLKTKVMKLENELEMAQQSAGGRDTR 111
++AQ EL ++ +K E QA +N K+ +LE + Q+ R
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE--R 1131
Query: 112 FLRNEICQLEKQLEQKDRELEDMEKELE----KEKKVNEQLALRNEEAENENSKLRRENK 167
RN+ EKQ ELE ++ ELE E A R +E L E +
Sbjct: 1132 AARNKA---EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR 1188
Query: 168 RLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTE 227
+ + +++ Q +++ Q E + + L K+N +L E++ L +
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLA---GELRVLGQ 1245
Query: 228 ANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAI----VHQTDNVID----------- 272
A +++E +K LE VQE++ + R +A VH+ N ++
Sbjct: 1246 AKQEVE----HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1301
Query: 273 ---QLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQ 329
+L K+ Q+Q+ +LL+ + + + V+ K+ + + +S D++ E +
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQK----LNVSTKLRQLEEERNSLQDQLDEEME 1357
Query: 330 MLHNLREKLK--NAQLDADK-------SNVMALQQGIQERDSQIKMLTEQVEQYTKEMEK 380
NL + N QL K S V AL++G + +I+ LT+Q E+ +K
Sbjct: 1358 AKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417
Query: 381 NTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLD--------ILKEKTKEAERTAE---L 429
+E KN LQ+ + ++ S L+ +L E+ + + A+
Sbjct: 1418 ----LEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDR 1473
Query: 430 AEADAREKD-------KELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIE-- 480
AEA+AREK+ + L EAL+ ++ E L+ + ++ + K+ + E+E
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKS 1533
Query: 481 --ILTKEINKLELKISDFLDENEALRE-RVGLEPKTMIDLTEFRNSKHLKQQQYRAENQI 537
L ++ +++ ++ + DE +A + ++ LE +F + +Q + +
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593
Query: 538 LLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLL 597
L +++ E E D +K+ A + K +DL L Q D + + +
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGD----LKDLEL-----QADSAIKGREE-- 1642
Query: 598 SLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQA 657
++K + + Q++ + REL + + + + K K L + QL+E L A
Sbjct: 1643 AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED----LAA 1698
Query: 658 IKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQ 717
+ +K D++ E + E L +++ +NA + D L+A++ QL EEL +
Sbjct: 1699 AERARKQADLEKEELA------EELASSLSGRNA--LQDEKRRLEARIAQL---EEELEE 1747
Query: 718 ELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASII 777
E + EA+ S ++ KA + + L E + R + N S+ +
Sbjct: 1748 E--QGNMEAM--SDRVRKATQQAEQLSNELATERSTAQKN-------------ESARQQL 1790
Query: 778 NSQNEYLIHLLQELENKEK-KLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTE 836
QN+ L L E+E K K K+ +LE K A + Q +E + ++ K +
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALE---AKIAQLEEQVEQEAREKQAATKSLKQK 1847
Query: 837 SKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSL 896
K +KE ++ED+ ++ A + KE NA ++K+ L E + + N + L
Sbjct: 1848 DKKLKEILLQVEDE-RKMAEQYKEQAEKGNARVK---QLKRQLEEAEEESQRINANRRKL 1903
Query: 897 IRQYTTLVELERQLRKENEKQKNEL 921
R+ E + +E K++L
Sbjct: 1904 QRELDEATESNEAMGREVNALKSKL 1928
Score = 120 bits (301), Expect = 2e-26
Identities = 193/835 (23%), Positives = 351/835 (42%), Gaps = 131/835 (15%)
Query: 1646 KVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLK 1705
KV L+ R+ E++ KE E LQ+ E + +K + E+++L+ Q +E L+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDE-----LQKTKERQ-QKAENELKELEQKHSQLTEEKNLLQ 893
Query: 1706 SELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIIS 1765
+LQA+ E + A E ++ +LA K+++ L L E+ A + EE
Sbjct: 894 EQLQAETELYAEA---------EEMRVRLAAKKQE---LEEILHEMEARLE---EEEDRG 938
Query: 1766 ATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNL---NDL 1822
Q E QQ++D L+ Q+E+ KL+ T++ + L D + +D
Sbjct: 939 QQLQAERKKMAQQMLD-----LEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ 993
Query: 1823 NNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVK 1882
NN+L K++K L+ +I LT+ L + EE + +
Sbjct: 994 NNKLSKERKL-----------------LEERISDLTTNLAEE----------EEKAKNLT 1026
Query: 1883 KLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQ 1942
KL+N+ E + E++++ KE+ +++EL +K + K+EG + E ++ L Q
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQEL------EKLKRKLEGDASDFHE---QIADLQAQ 1077
Query: 1943 LNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILY 2002
+ LK AK ++E +L + L K++ EL+ DL+ D+
Sbjct: 1078 IAELKMQLAKKEEELQAALARLDDEIAQKNNAL--------KKIRELEGHISDLQEDLDS 1129
Query: 2003 MRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQ 2062
RA + Q R L E+L AL+ + +DT + + + +REQE+
Sbjct: 1130 ERAAR--------NKAEKQKRDLGEELEALKTEL-EDTLDS---TATQQELRAKREQEVT 1177
Query: 2063 KENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGR 2122
L E + Q+++ + + V +L E E K+ KA + +
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQ---KHAQAVEELTEQLEQFKRAKANLDK---------- 1224
Query: 2123 SGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKA 2182
+ +T+ + + +V+ + ++E E KK E + + E+ +AEL
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCS-DGERARAELNDKV- 1282
Query: 2183 HLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLE 2242
H+L ES T NE K +K D A ++ E+L E+ +L
Sbjct: 1283 ---HKLQNEVESVTGML------NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLN 1333
Query: 2243 ETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKE 2302
+ K Q E R + D + + + E + L ++ + + D V+
Sbjct: 1334 VSTKLRQLEEERNSLQDQLDEE----MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA 1389
Query: 2303 ATEREQKVNKYNEDLEQQIKILKHVPEGAE-TEQGLKRELQVLRLANHQLDKEKAELIHQ 2361
E +++ K E+L QQ + + E T+ L++EL L + LD ++ +L+
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV---DLDNQR-QLVSN 1445
Query: 2362 IEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQ-------HLKEEIKKLKKELE 2414
+E K Q + + + + K D + + EK+ EE + K+ELE
Sbjct: 1446 LE--KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELE 1503
Query: 2415 NFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDE 2469
+ E+EDL + K++V KN+ EK K+ E E+ + + EE EDE
Sbjct: 1504 RTNKMLKAEMEDL-VSSKDDVGKNVHELEKSKRALETQMEEMKTQL---EELEDE 1554
Score = 82.4 bits (202), Expect = 5e-15
Identities = 98/469 (20%), Positives = 199/469 (42%), Gaps = 38/469 (8%)
Query: 4 NINWKEIMKVDPDDLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKA 63
NI+ K + D + +E+ L ++ + E E K E + L + L+ K
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK- 1520
Query: 64 QEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL----------EMAQQSAGGRDTRFL 113
+V + E+EK+ ++KT++ +LE+EL E+ Q+ G+ R L
Sbjct: 1521 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1580
Query: 114 RNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKN 173
+ Q E++ Q R+L + E ELE E+K A ++ E + L + K
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGR 1640
Query: 174 EQLCQDIIDYQKQI-DSQKETLLSRRGEDSDY----RSQLSKKNYE--LIQYLDEIQTLT 226
E+ + + Q Q+ D Q+E +R D + ++ K+ E L+Q +++
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE 1700
Query: 227 EANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQ----LKKENDHYQ 282
A ++ +++ +E+ + L S+ + DE R++A + Q + +++ ++ +D +
Sbjct: 1701 RARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVR 1760
Query: 283 LQVQELTDLLKSKNEEDDPIMVAVNAK--VEEWKLILSSKDDEI-----IEYQQMLHNLR 335
Q+ L E +A+ +E L SK E+ +++ + L
Sbjct: 1761 KATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE 1820
Query: 336 EKLKNA--QLDADKSNVMALQQGIQERDSQIKMLTEQVE-------QYTKEMEKNTCIIE 386
K+ Q++ + A + ++++D ++K + QVE QY ++ EK ++
Sbjct: 1821 AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVK 1880
Query: 387 DLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAR 435
LK +L+ + S K+Q LD E + R ++ R
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLR 1929
Score = 76.6 bits (187), Expect = 3e-13
Identities = 104/448 (23%), Positives = 199/448 (44%), Gaps = 47/448 (10%)
Query: 2040 TYSKPSISGIESDDHCQ-REQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKE 2098
T KP + ++ Q +E ELQK + ELK +LEQ + L KN +++ +
Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELK-ELEQKHSQLTEEKNLLQEQLQ 897
Query: 2099 MCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGIL 2158
L E E++ +L + ELE+ + M+ +E+ + +QL+ A
Sbjct: 898 AETELYAEAEEMRVRLAAKK---------QELEEILHEMEARLEEEEDRGQQLQ-AERKK 947
Query: 2159 TSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIA----ENERLRKELK 2214
+++M ++E++ E+ +A +KL+ + E+K K E I +N +L KE K
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLE-----KVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 2215 K--------ETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSW 2266
T+ AE+ AKN L L K + E RL+ E +LE
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKN-LTKLKNKHESMISELEVRLKKEEKSRQELEK------ 1055
Query: 2267 KSIVVTRMYETKLKELETDIAKKNQSITDLK-QLVKEATEREQKVNKYNEDLEQQIKILK 2325
+ R E + IA I +LK QL K+ E + + + ++++ Q+ LK
Sbjct: 1056 ----LKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111
Query: 2326 HVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKD--QSGAESTIPDADQLKE 2383
+ E L+ +L R A ++ +K+K +L ++EA K + +ST + +
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1171
Query: 2384 KIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEE 2443
+ +++ K D E + + ++++++++ E++E K K + KN ++
Sbjct: 1172 REQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFK-RAKANLDKN---KQ 1227
Query: 2444 KVKKLSEQLGVELTSPVAASEEFEDEEE 2471
++K + L EL A +E E +++
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKK 1255
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 171 bits (433), Expect = 8e-42
Identities = 351/1737 (20%), Positives = 727/1737 (41%), Gaps = 210/1737 (12%)
Query: 861 YNNLLNALQMDSDEMKKILAENSR-KITVLQVNEKSLIRQYTTLVELERQLRKENEKQKN 919
Y LL +L+ + E + S K LQ+ + + L+++ +E ++
Sbjct: 965 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1024
Query: 920 ELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSL-SELELAN---KQYNELTAK 975
E +AEV E +G K+ AL + + +L SELEL +Q L+A
Sbjct: 1025 EQQKAQAEV-EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1083
Query: 976 YRDILQKDNMLVQRTSNLEH-LECENISLKEQ--VESINKELEITKEKLHTIEQAWEQET 1032
Y + L+ +++++ T E L LKE V + ELE TK L + E +
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ- 1142
Query: 1033 KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE 1092
+ + D + + + V + E ER R E ++ E + L Q +
Sbjct: 1143 ----QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDV 1197
Query: 1093 RNFELETKFAELTKINLDAQKVEQMLRD-ELADSVSKAVSDADRQRILELEKNEMELKVE 1151
R ELE +L A + L+D +A+ AD Q + E + E L E
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 1152 VSKLRE-ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSD------EKSLIAKLH 1204
+ + E + + R + +NA ++ +QL+ Y+AQ + +K +
Sbjct: 1258 IERHGEKVEECQRFAKQYINA--------IKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309
Query: 1205 QHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLR 1264
+ + + T +L ++TS+ K + LR +++E+E+ R E R R +
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERERLAEVE 1366
Query: 1265 QTIQSLRRQFSG-ALPLAQQEKFSKTMIQ-LQNDKLKIMQEMKNSQQEHRNMENKTLEME 1322
++ R+ A AQ E+ +K + Q +Q + ++ + ++QQ+ R+++ + +
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL--QQ 1424
Query: 1323 LKLKGLEELISTLKDTKGAQKVINWHMKIEE----LRLQELKLNRELVKDKEEIKYLNNI 1378
L+ E+ + + + A++ ++IEE +RLQ R+ + E++ L
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERS---RLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1481
Query: 1379 ISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDI---FDRQQNEILNAAQKF 1435
E E +EE + + ++ Q EV+L ++ R++ L A ++
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541
Query: 1436 ----EEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLA 1491
EEA + + Q+++AL + + L+++ S EK + E +L+
Sbjct: 1542 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA--SFAEKTAQLERSLQ-E 1598
Query: 1492 EQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQ 1551
E +++ + E R + A AER + AE + + K++ L++ Q Q Q
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ----Q 1654
Query: 1552 KEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSP 1611
K + ++ E+A E R K E+ + R A+ L K +Q A +Q
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAV-----RQRELAEQELEKQRQLAEGTAQQ-- 1707
Query: 1612 TPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFEN---I 1668
RLA AEQ+ L++L+ ++ E+QR++ E ++ +
Sbjct: 1708 ----------RLA------AEQE------LIRLRAETEQGEQQRQLLEEELARLQREAAA 1745
Query: 1669 KLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANS------RAPTTT 1722
Q ++ E E+ KV+AE+E L ++++ES+ + + + EA +
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 1723 MRNLVERLKSQLALKE----KQQKALSRALLELRA---EMTAAAEERIISATSQKEAHLN 1775
+R L E K Q L E +Q+ R L E A E T E I+ ++ +
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1865
Query: 1776 VQQIVDRHT---RELKTQVE----DLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQK 1828
++++ + R L+ Q D+ E L +L++A + R+ L ++ L++
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------LRQ 1919
Query: 1829 KQKAYNKILREKEEIDQE---NDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE 1885
+++ +IL K ++ EL+ ++ R+ S + + + L QR++ E
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 1886 NQLEGKVEEVDLKPM--KEKNAKEELIRWEEGKKWQAKIEG---IRNKLKEKEGEVFTLT 1940
+ + EE K + +E+ A++ EE ++ +AK+E +R + +++ L
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 1941 K-------QLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGI---------------- 1977
+ Q FA KE+ LQ+ L+ +DQ+ G
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2098
Query: 1978 ----RALESEKELEELKKRNLDLENDI------------LYMRAHQALPRDSVVEDLHLQ 2021
A +S +++EE ++ E L A Q R + E L+
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158
Query: 2022 NRYLQEKLHALEKQFSKDTY-SKPSISG--------IESDDHCQR--EQELQK------- 2063
+ + K+F++ T K + +E DH + ++ELQ+
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 2064 ---ENLKLSSENIELKFQLEQANKDLPRLKNQ-----VRDLKEMCEFLKKEKA---EVQR 2112
+ ++ E ++ Q+E+ +K R++ + +RD FL++E +V
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278
Query: 2113 KLGHVRGSGRSGKTIPEL-EKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171
+ + + + + +L E+ + + + EK+ +E Q + + L +E A + Q+ +
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQK 2336
Query: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLE 2231
+L E + Q++ +T+G ++ + + + E+ E + KLR+A+ +
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMS-- 2393
Query: 2232 ILNEKMTVQLEETGKRLQF-AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN 2290
+ + EE +R + AE G +L + + + + + + E + ++ + D +
Sbjct: 2394 ----RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2449
Query: 2291 QSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQ 2350
++I +L++ KE ++E K+ + + Q ++ + + E +Q E L
Sbjct: 2450 EAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Query: 2351 LDKEKAEL--IHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
+++EKA+L + Q E K Q E Q++++ + L ++ + + +E +++
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 2409 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELT-SPVAASE 2464
++EL+ + ++ E+L + +++ + L E+ + + E+T S VAA++
Sbjct: 2569 KQEELQQLEQQRRQQ-EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624
Score = 145 bits (367), Expect = 4e-34
Identities = 388/1985 (19%), Positives = 766/1985 (38%), Gaps = 335/1985 (16%)
Query: 53 RITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRF 112
R+ L K A+E + E +KA E + + E L + + S
Sbjct: 1006 RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT--- 1062
Query: 113 LRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKK 172
LR+E+ +LEQ R L + LEK K ++ L +R + E LR ++LK+
Sbjct: 1063 LRSELELTLGKLEQV-RSLSAIY--LEKLKTIS--LVIRGTQGAEE--VLRAHEEQLKE- 1114
Query: 173 NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKI 232
Q + ++++ K +L R + ++ + ++ ++ DE++ E E++
Sbjct: 1115 ----AQAVPATLPELEATKASLKKLRAQ-----AEAQQPTFDALR--DELRGAQEVGERL 1163
Query: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTD---NVIDQLKKENDHYQLQVQELT 289
+ ++ E +E + E++ R +A++ QTD ++QL ++ +Y+ L
Sbjct: 1164 QQRHGERDVEVE---RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1220
Query: 290 DLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLR---EKLKNAQLDAD 346
L+ + I A + + +++ + Q +L + EK++ Q A
Sbjct: 1221 AWLQDARRRQEQIQAMPLADSQAVR-------EQLRQEQALLEEIERHGEKVEECQRFA- 1272
Query: 347 KSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEK------NTCIIEDLKNELQRNKGAST 400
K + A I++ + Q+ Q+E +K + +I++ + +T
Sbjct: 1273 KQYINA----IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328
Query: 401 LSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDY-ESGVYGLE 459
L+ Q I TL + +E ER AE A+ RE+ E+ AL++ + E+
Sbjct: 1329 LTSQYIKFISETL----RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384
Query: 460 DAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTE 519
A E K + +++ +E+ + E D + +++E +L +
Sbjct: 1385 QAEREAKELQQRMQ----------EEVVRREEAAVDAQQQKRSIQE----------ELQQ 1424
Query: 520 FRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQM-----AQERGKRSATSGLTT 574
R S AE Q ++ E+ E RL ++++IR + A ER + A L
Sbjct: 1425 LRQSSE-------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 575 EDLNLTENISQGDRISERKLDLLSLKNMSEAQSKN----EFLSRELIEKERDLERSRTVI 630
E +Q R ++ + + L + E+Q K E SR E E E+ R
Sbjct: 1478 LRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-- 1534
Query: 631 AKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNA-IESK 689
L+ L E Q EE + + QA E + + + + + +R A ++SK
Sbjct: 1535 ------LQALEELRLQAEEAERRLRQAEVERAR-------QVQVALETAQRSAEAELQSK 1581
Query: 690 NAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSL 749
A + QL +E + + R+EA +QQ A+A + E+E
Sbjct: 1582 RAS--------FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 750 --LRQSEGSNVVFKGIDLPD--GIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSL 805
L+ +E + + ++ +A + A + E + E + + + L +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 806 EDYNRKFAVIRHQQSLLYKEYL----SEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEY 861
+ R+ A QQ L ++ L +E E + + + ++EE +L+ + K +E
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 862 NNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNEL 921
L ++ EM+ +LA +R E + R +EK K L
Sbjct: 1754 EAELAKVRA---EMEVLLASKARA---------------------EEESRSTSEKSKQRL 1789
Query: 922 LSMEAEVCEKIGCLQRFKEMA--IFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI 979
EAE RF+E+A ++ AL + L+E + A ++
Sbjct: 1790 ---EAEA-------GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----------- 1828
Query: 980 LQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTI-EQAWEQETKLGNES 1038
+ + +L ++ + + E LK + E KE E E+L + E Q +L ++
Sbjct: 1829 AEAERVLAEKLAAIG----EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 1039 SMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1098
+ KA I +++ L +E +R + + E +Q+EE L+
Sbjct: 1885 AQHKA----------DIEERLAQLRKASDSELERQKG---LVEDTLRQRRQVEEEILALK 1931
Query: 1099 TKF----AELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELE----KNEMELKV 1150
F A ++ L+ ++ D L S +A +A RQR L E + E E +V
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERV 1990
Query: 1151 EVSKLRE----------ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLI 1200
+ S E + ++ R + ++ A++ E ES R L +A +K L
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA--QKRLQ 2048
Query: 1201 AKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA 1260
A+ H ++Q E L+ S L ++ + +E E+A R++ A
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA----RVQAEREA 2104
Query: 1261 KHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLE 1320
R+ ++ R A AQ ++ Q +KL+ K E
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQ----ARAQAQAAAEKLR-----------------KEAE 2143
Query: 1321 MELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIIS 1380
E + E + L+ + A + H K E L R+ + ++E+ L +
Sbjct: 2144 QEAARRAQAEQ-AALRQKQAADAEMEKHKKFAEQTL------RQKAQVEQELTTLRLQLE 2196
Query: 1381 EYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG 1440
E + + L+EE+ + E A QR + + E+ + + EE
Sbjct: 2197 ETDHQKNLLDEEL---QRLKAEATEAARQRS-----------QVEEELFSVRVQMEE--- 2239
Query: 1441 SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK 1500
L K+K RI E RA L++K++ R ++ + K
Sbjct: 2240 ----------------LSKLKA--RIEAENRALI------LRDKDNTQRFLQEEA-EKMK 2274
Query: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
+ E RL A+ + +L +++ + K+ + + +Q K E
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA----- 2329
Query: 1561 RLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF 1620
LL++ +E +E ++ +ED + +L A+ + + + +Q +
Sbjct: 2330 ELLQQQKELAQEQARRLQEDKEQMAQQL---AEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Query: 1621 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHED-- 1678
+R+AEM + A ++ + +++ + L R T+ KV + +++Q Q++ D
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2446
Query: 1679 EVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738
+++ AE+E K L Q K Q E+Q ++ T ++ K L +E
Sbjct: 2447 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2506
Query: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENL 1798
R + + +A++ ++ + A +E QQ +++ + L +E+
Sbjct: 2507 -------RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 1799 LKLKEALKTS-----------KNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEN 1847
+ +E ++ + +E L + L +LQ ++ + L EE+
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Query: 1848 DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKE 1907
+ + L G + + L+RKV Q G + +L+ + + +
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTV 2679
Query: 1908 ELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLT----LQRK 1963
+ + A+ E +R+ L+ + +++ L KA EKL+ LQR+
Sbjct: 2680 DEL---------ARREDVRHYLQGR-----------SSIAGLLLKATNEKLSVYAALQRQ 2719
Query: 1964 LKTTG 1968
L + G
Sbjct: 2720 LLSPG 2724
Score = 137 bits (346), Expect = 1e-31
Identities = 374/2011 (18%), Positives = 809/2011 (40%), Gaps = 281/2011 (13%)
Query: 641 VEENKQLEEG----MKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696
V+ +LE+ ++++L ++E Q D G E + +PS+E + + G+
Sbjct: 511 VQRRPELEDSTLRYLQDLLAWVEENQHRVD--GAEWGVDLPSVEAQLGS-----HRGLHQ 563
Query: 697 ASLHLKAQVDQLTGRNEELRQELRESRKEAIN-----YSQQLAKANLKIDHLE------- 744
+ +A++++ +L R + ++ + Y++ L + ++ LE
Sbjct: 564 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVA 623
Query: 745 ---KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNL 801
KE L + E V F D + ++ E L++ELE KEKK+K L
Sbjct: 624 AATKELMWLNEKEEEEVGFDWSDRNTNMT--------AKKESYSALMRELELKEKKIKEL 675
Query: 802 EDS-----LEDYNRKFAVIRHQQSL------------LYKEYLSEKETWKTESKTIKEEK 844
+++ ED+ + V Q +L + +L E + ++E +
Sbjct: 676 QNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAE 735
Query: 845 RKLEDQVQQDAIKVKEYN-------NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
+L Q Q+A++ ++Y+ L L D+ + K+ L E ++ L K+++
Sbjct: 736 GQL--QKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 792
Query: 898 ----RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953
R + L + ++ E+ + + C+ +G Q + + + V
Sbjct: 793 QLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQP-SHWKVLSSSGSEAAV 851
Query: 954 DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENI----SLKEQVES 1009
+ L + N++ E + L+ + + + H++ +++ SL+ V+
Sbjct: 852 PSVCFL--VPPPNQEAQEAVTR----LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 905
Query: 1010 INK---------ELEITKEKLHTIE---QAWEQETKLGNESSMDKAKKSITNSDIVSISK 1057
I + E ++ LH++E QA+ ++++ + + + + S S
Sbjct: 906 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQ--DAGGFGPEDRLMAEREYGSCSH 963
Query: 1058 KITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLD------- 1110
L Q CQ+ L+ Q+E ET+ ++ LD
Sbjct: 964 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE----ACETRTVHRLRLPLDKEPAREC 1019
Query: 1111 AQKV-EQMLRDELADSVSKAVS--DADRQRILELE---------KNEMELKV-EVSKLRE 1157
AQ++ EQ + + K V+ A+ +++L L ++E+EL + ++ ++R
Sbjct: 1020 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1079
Query: 1158 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA 1217
+S I +++ ++ + E LR + + + +L SL+ A A
Sbjct: 1080 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1139
Query: 1218 LGK---LESITSKLQKMEAYNLRLEQKLDEKEQALYYAR--------------LEGRNRA 1260
+ +++ +L+ + RL+Q+ E++ + R + R
Sbjct: 1140 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1199
Query: 1261 KHLRQTIQSLRRQFSGALPLA---QQEKFSKTMIQLQ--NDKLKIMQEMKNSQQEHRNME 1315
+ L Q + LR A PL Q + + IQ D + ++++ Q +E
Sbjct: 1200 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259
Query: 1316 NKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELK---------LNRELV 1366
++E + ++ I+ +KD + +++ + ++E + K + +E V
Sbjct: 1260 RHGEKVEECQRFAKQYINAIKDYE--LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1317
Query: 1367 KDKEEIKYLNNIISEYERTISSL------EEEIVQQNKFHEERQMAWDQREVDLERQLDI 1420
+ L + S+Y + IS EE + +Q + E ++A + E LE+Q +
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQL 1375
Query: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEK 1480
+ A ++ +E + + + + E A+ ++ I E + +S E +
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1432
Query: 1481 LKEKESALRLAEQNILSRDKVINELRLRLPAT------AEREKLIAELGRKEMEPKSHHT 1534
++ K AE++ L ++ I +RL+L AT AE E +E E +
Sbjct: 1433 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1492
Query: 1535 LKIAHQTIANMQARLNQKE----EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 1590
+ A + +Q +K E+ + + E ARE+QR + E L L
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---------LRL 1543
Query: 1591 QADSSLNKFKQTAWDLMKQSPTPVPTNKHFI------RLAEMEQTVAEQDDSLSSLLVKL 1644
QA+ + + +Q + +Q + T + + A + A+ + SL V +
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Query: 1645 KKVSQDLER--QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDL--KYLLDQSQKE 1700
++ ++ ER Q++ + +E +L+ + +E +++ + E++ + L Q++ E
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Query: 1701 SQCLKSELQAQKEANSRAPTTTMRNLVER-LKSQLALKE---KQQKALSRALLELRAEMT 1756
Q ++E +A++ + R L E+ L+ Q L E +Q+ A + L+ LRAE
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 1757 AAAEERII----SATSQKEAHLNVQ--QIVDRHTRELKTQVEDLNENLLKLKEALKT--- 1807
++R + A Q+EA Q Q ++ +++ ++E L + + +E ++
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 1808 -SKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPL 1866
SK R + +L E + + + R+++ +++ + + +R+ +
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA------- 1836
Query: 1867 TDNKQSLIEELQRKVKKLENQL-EGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIE-- 1923
K + I E R + E L E + E L+ + E A + E+ + +A IE
Sbjct: 1837 --EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 1924 ------GIRNKLKEKEGEVFTLTKQ-------LNTLKDLFAKADKEKLTLQRKLKTTGMT 1970
++L+ ++G V +Q + LK F KA K L+ +L
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 1971 VDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLH 2030
+ L + + ELE ++R L E + A + + + E+ + R + L
Sbjct: 1955 AEDTL---RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALE 2009
Query: 2031 ALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQ-ANKDLPRL 2089
+E+ +K E+ +R ++ L+L+ E + + Q E+ A+ +
Sbjct: 2010 EVERLKAKVE---------EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 2090 KNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENE 2149
K Q E+ + L++E++ + + G + R+ + E +VQ E E
Sbjct: 2061 KEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------------ARVQAERE 2103
Query: 2150 QLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERL 2209
+ + +E++ +E + +A+ + L + + + + + + +
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 2210 RKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETG--KRLQFAESRGPQLEGADSKSWK 2267
E++K AE+ K +E + +QLEET K L E + + E ++ +
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 2268 SIVVTRMYETK-----LKELETDIAKKNQSITDLKQLVKEATER--EQKVNKYNEDLEQQ 2320
S V ++ + L +L+ I +N+++ L+ K+ T+R +++ K + E+
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALI-LRD--KDNTQRFLQEEAEKMKQVAEEA 2280
Query: 2321 IKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQ 2380
++ E A Q + +L R ++ KEK + + EA + ++ AE +
Sbjct: 2281 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKEL 2338
Query: 2381 LKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFE---EIEDLKYNYKEEVKK 2437
+E+ + L+ + Q L EE + ++ LE E E E LK E +
Sbjct: 2339 AQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395
Query: 2438 NILLEE---KVKKLSEQLGVELTSPVAASEE 2465
EE + +K +E++G +L A++E
Sbjct: 2396 QARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Score = 130 bits (327), Expect = 2e-29
Identities = 247/1349 (18%), Positives = 554/1349 (41%), Gaps = 139/1349 (10%)
Query: 39 ELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL 98
E EKQ + ++ + +A+E++ ++E EE A Q K + + +L
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 99 EMA----------QQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQL 148
+ Q A R + EI + QLE +R+ E EL+ + E+
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
Query: 149 ALRNEEAENENSKLRR----ENKRLKKKNEQLCQDI-------IDYQKQIDSQKETLLSR 197
+ +A+ E +LRR E++R ++ +L + + Q+ + + +E L
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1545
Query: 198 RGEDSDYRSQLSKKNYELIQYLDEIQTLTEAN-EKIEVQNQEMRKNLEESVQE----MEK 252
+ R ++ ++ L+ Q EA + E LE S+QE + +
Sbjct: 1546 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1605
Query: 253 MTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDL-LKSKNEEDDPIMVAVNAKVE 311
+ +E R + + ++ ++E + +QL+ E L L+++ + A+ +
Sbjct: 1606 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
Query: 312 EWKLILSSK-----DDEIIEYQQMLHNLREKLKN------AQLDADKSNVMALQQGIQER 360
+ + ++ +++ + +++ EK + Q A + ++ L+ ++
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQR---------------NKGASTLSQQT 405
+ Q ++L E++ + +E T ++L+ EL + + + + S+++
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 406 HMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEI 465
++++ +E +EA R LAE R++ +A ++ + E + A+ E
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845
Query: 466 KNCKNQIKIRDREIEILTKEINKL--ELKISDFLDENEALRERVGLEPKTMIDLTEFRNS 523
K + +I +E E + + +L + E +A + + +E + L + R +
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKA 1901
Query: 524 KHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSG---LTTEDLNLT 580
+ ++ + + L++ +EEE L LK + A + + G ED +
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 581 ENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKEL 640
+ ++ + +R+L + EA+ + ++ + E + R R + +LK
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 641 VEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLH 700
VEE ++L E ++ ++ +++Q E + E +A + E +L
Sbjct: 2018 VEEARRLRERAEQ--ESARQLQ-----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070
Query: 701 LKAQV-DQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVV 759
+ V DQL G E R+ E+ + + ++ A++ +++ E+ L+QS
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER----LKQSAEEQAQ 2126
Query: 760 FKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQ 819
+ A ++A + + E + E + K D+ + ++KFA +Q
Sbjct: 2127 AR------AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 820 SLLYKEYLS----EKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEM 875
++ L+ + E + + EE ++L+ + + A + + L ++++ +E+
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240
Query: 876 KKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEA----EVCEK 931
K+ A + L + +K +++ E E+ + E + + + EA ++ E+
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 932 IGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTS 991
QR + K +Q V + + +E EL +Q EL + LQ+D + +
Sbjct: 2300 DLAQQRALAEKMLK-EKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQL 2357
Query: 992 NLEHLECENISLKEQVESINKELEITKEKLHTIE----QAWEQETKLGNESSMDKAKKSI 1047
E + E+ + E + KL E QA +E ++ + +
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 1048 TNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFEL--ETKFAELT 1105
+++ + +K+T+++ E+ +RQ+++H E LR ++ ++E +L E K +L
Sbjct: 2418 HRTELAT-QEKVTLVQTLEI-QRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 1106 KINLDAQKVEQMLRDELA---DSVSKAVSDADRQRILELEKNEME--LKVEVSKLREISD 1160
+ + EQ+L++ A +S+ S R+R +E EK ++E + EV+K +++ +
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 1161 IARRQVEILNAQQQSRDKEVESLR----------------MQLLDYQAQSDEKSLIAKLH 1204
+RQ + + ++Q +E R +Q L+ Q + E+ L +
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2592
Query: 1205 QHNVSLQLSE---ATALGKLESITSKLQKMEAYNLRLEQKLDEKEQAL--YYARLEGRNR 1259
+ LQL E AL E +T A + + L AL A E +
Sbjct: 2593 RLREQLQLLEEQHRAALAHSEEVT-------ASQVAATKTLPNGRDALDGPAAEAEPEHS 2645
Query: 1260 AKHLRQTIQSLRRQFSGALPLAQQEKFSK 1288
LR+ + + R Q +G L + ++ ++
Sbjct: 2646 FDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674
Score = 53.9 bits (128), Expect = 2e-06
Identities = 233/1241 (18%), Positives = 475/1241 (38%), Gaps = 202/1241 (16%)
Query: 1353 ELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEE--RQMAWD-- 1408
+L + L+ ++L + E ++ L I+++ + EE++ Q + + R +A
Sbjct: 372 KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKV 431
Query: 1409 -QREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRII 1467
QR ++ER LD D + N Q ++ + +L L I+ +
Sbjct: 432 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 491
Query: 1468 LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLI------AE 1521
L+ + + +S R E D + L+ L E + + +
Sbjct: 492 LKAGVAAPATQVAQVTLQSVQRRPELE----DSTLRYLQDLLAWVEENQHRVDGAEWGVD 547
Query: 1522 LGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDL 1581
L E + SH L HQ+I +A++ E+AR ++ ++
Sbjct: 548 LPSVEAQLGSHRGL---HQSIEEFRAKI--------------ERARSDEGQLSPATRGAY 590
Query: 1582 HILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLL 1641
RL+LQ LN K L K + L E E+ D S +
Sbjct: 591 RDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 650
Query: 1642 VKLKKVSQD-LERQREITELKVKEFEN--------------------------------- 1667
+ KK S L R+ E+ E K+KE +N
Sbjct: 651 MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 710
Query: 1668 ---IKLQLQENHE-----DEVKKVKAEVEDL------KYLLDQSQKESQC--LKSELQAQ 1711
I+ L+EN +V++ + +++ L KY D+S ++ L + Q +
Sbjct: 711 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 770
Query: 1712 KEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRA-----------------E 1754
KE + + L +R K+ + LK + R L L A +
Sbjct: 771 KEQLNEYKGH-LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQ 829
Query: 1755 MTAAAEE---RIISATSQKEAHLNVQQIV---DRHTRELKTQVEDLNENLLKLKEALKT- 1807
+ A+ +++S++ + A +V +V ++ +E T++E ++ L+ L L
Sbjct: 830 LVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 889
Query: 1808 --------SKNRENSL----------TDNLNDLNNELQKKQKAYNKILREKEEI------ 1843
S R+ L T + L + Y LR+ ++
Sbjct: 890 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 949
Query: 1844 -----DQENDELKRQIKRLTSGL-QGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDL 1897
++E ++L L QG Q I EL+ +LE V + L
Sbjct: 950 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1009
Query: 1898 KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEK 1957
P+ ++ A+E R E +K QA++EG+ + E +++ L + A
Sbjct: 1010 -PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA----EKVLALPEPSPAAP--- 1061
Query: 1958 LTLQRKLKTTGMTVDQVLGIRALESEK-ELEELKKRNLDLENDILYMRAHQALPRDSVVE 2016
TL+ +L+ T ++QV + A+ EK + L R ++L RAH+ +++
Sbjct: 1062 -TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL--RAHEEQLKEAQAV 1118
Query: 2017 DLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELK 2076
L L+ +L+K ++ +P+ + D + QE+ + +L + E
Sbjct: 1119 PATLPE--LEATKASLKKLRAQAEAQQPTFDALR--DELRGAQEVGE---RLQQRHGERD 1171
Query: 2077 FQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS-GKTIPELEKTIG 2135
++E+ + + +L + + + + ++E ++ R+L + R S G + + +
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1231
Query: 2136 LMKKV-VEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG--HQLSMHY 2192
++ + + Q EQL++ +L IE+ EK++ K ++ +
Sbjct: 1232 QIQAMPLADSQAVREQLRQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQL 1286
Query: 2193 ESKTKGTEKIIAENERLRKELKKETDAAE--KLRIAKNNLEILNEKMTVQLEETGKRLQF 2250
+ E + + ++ + + E+ E LR + L L + + ET +R++
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1346
Query: 2251 AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKV 2310
E Q + + +L E+E + K+ Q + + K ERE K
Sbjct: 1347 EERLAEQQRAEERE-------------RLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKE 1392
Query: 2311 NKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSG 2370
+ E+ ++ + + + ++ ++ ELQ LR ++ +AE+ Q +A + ++
Sbjct: 1393 LQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQSS------EAEI--QAKARQAEAA 1443
Query: 2371 AESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYN 2430
S + +++E+I+ + QL+ ++ ++ + E++ L+ E E E K
Sbjct: 1444 ERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQALRARAE--------EAEAQKRQ 1491
Query: 2431 YKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEE 2471
+EE ++ + + Q VEL S V A E E++
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 171 bits (433), Expect = 8e-42
Identities = 351/1737 (20%), Positives = 727/1737 (41%), Gaps = 210/1737 (12%)
Query: 861 YNNLLNALQMDSDEMKKILAENSR-KITVLQVNEKSLIRQYTTLVELERQLRKENEKQKN 919
Y LL +L+ + E + S K LQ+ + + L+++ +E ++
Sbjct: 969 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1028
Query: 920 ELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSL-SELELAN---KQYNELTAK 975
E +AEV E +G K+ AL + + +L SELEL +Q L+A
Sbjct: 1029 EQQKAQAEV-EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1087
Query: 976 YRDILQKDNMLVQRTSNLEH-LECENISLKEQ--VESINKELEITKEKLHTIEQAWEQET 1032
Y + L+ +++++ T E L LKE V + ELE TK L + E +
Sbjct: 1088 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ- 1146
Query: 1033 KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE 1092
+ + D + + + V + E ER R E ++ E + L Q +
Sbjct: 1147 ----QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDV 1201
Query: 1093 RNFELETKFAELTKINLDAQKVEQMLRD-ELADSVSKAVSDADRQRILELEKNEMELKVE 1151
R ELE +L A + L+D +A+ AD Q + E + E L E
Sbjct: 1202 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1261
Query: 1152 VSKLRE-ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSD------EKSLIAKLH 1204
+ + E + + R + +NA ++ +QL+ Y+AQ + +K +
Sbjct: 1262 IERHGEKVEECQRFAKQYINA--------IKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1313
Query: 1205 QHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLR 1264
+ + + T +L ++TS+ K + LR +++E+E+ R E R R +
Sbjct: 1314 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERERLAEVE 1370
Query: 1265 QTIQSLRRQFSG-ALPLAQQEKFSKTMIQ-LQNDKLKIMQEMKNSQQEHRNMENKTLEME 1322
++ R+ A AQ E+ +K + Q +Q + ++ + ++QQ+ R+++ + +
Sbjct: 1371 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL--QQ 1428
Query: 1323 LKLKGLEELISTLKDTKGAQKVINWHMKIEE----LRLQELKLNRELVKDKEEIKYLNNI 1378
L+ E+ + + + A++ ++IEE +RLQ R+ + E++ L
Sbjct: 1429 LRQSSEAEIQAKARQAEAAERS---RLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1485
Query: 1379 ISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDI---FDRQQNEILNAAQKF 1435
E E +EE + + ++ Q EV+L ++ R++ L A ++
Sbjct: 1486 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1545
Query: 1436 ----EEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLA 1491
EEA + + Q+++AL + + L+++ S EK + E +L+
Sbjct: 1546 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA--SFAEKTAQLERSLQ-E 1602
Query: 1492 EQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQ 1551
E +++ + E R + A AER + AE + + K++ L++ Q Q Q
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ----Q 1658
Query: 1552 KEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSP 1611
K + ++ E+A E R K E+ + R A+ L K +Q A +Q
Sbjct: 1659 KSLAQAEAEKQKEEAEREARRRGKAEEQAV-----RQRELAEQELEKQRQLAEGTAQQ-- 1711
Query: 1612 TPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFEN---I 1668
RLA AEQ+ L++L+ ++ E+QR++ E ++ +
Sbjct: 1712 ----------RLA------AEQE------LIRLRAETEQGEQQRQLLEEELARLQREAAA 1749
Query: 1669 KLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANS------RAPTTT 1722
Q ++ E E+ KV+AE+E L ++++ES+ + + + EA +
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1809
Query: 1723 MRNLVERLKSQLALKE----KQQKALSRALLELRA---EMTAAAEERIISATSQKEAHLN 1775
+R L E K Q L E +Q+ R L E A E T E I+ ++ +
Sbjct: 1810 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1869
Query: 1776 VQQIVDRHT---RELKTQVE----DLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQK 1828
++++ + R L+ Q D+ E L +L++A + R+ L ++ L++
Sbjct: 1870 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------LRQ 1923
Query: 1829 KQKAYNKILREKEEIDQE---NDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE 1885
+++ +IL K ++ EL+ ++ R+ S + + + L QR++ E
Sbjct: 1924 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1983
Query: 1886 NQLEGKVEEVDLKPM--KEKNAKEELIRWEEGKKWQAKIEG---IRNKLKEKEGEVFTLT 1940
+ + EE K + +E+ A++ EE ++ +AK+E +R + +++ L
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2043
Query: 1941 K-------QLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGI---------------- 1977
+ Q FA KE+ LQ+ L+ +DQ+ G
Sbjct: 2044 QEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2102
Query: 1978 ----RALESEKELEELKKRNLDLENDI------------LYMRAHQALPRDSVVEDLHLQ 2021
A +S +++EE ++ E L A Q R + E L+
Sbjct: 2103 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2162
Query: 2022 NRYLQEKLHALEKQFSKDTY-SKPSISG--------IESDDHCQR--EQELQK------- 2063
+ + K+F++ T K + +E DH + ++ELQ+
Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2222
Query: 2064 ---ENLKLSSENIELKFQLEQANKDLPRLKNQ-----VRDLKEMCEFLKKEKA---EVQR 2112
+ ++ E ++ Q+E+ +K R++ + +RD FL++E +V
Sbjct: 2223 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2282
Query: 2113 KLGHVRGSGRSGKTIPEL-EKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171
+ + + + + +L E+ + + + EK+ +E Q + + L +E A + Q+ +
Sbjct: 2283 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQK 2340
Query: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLE 2231
+L E + Q++ +T+G ++ + + + E+ E + KLR+A+ +
Sbjct: 2341 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMS-- 2397
Query: 2232 ILNEKMTVQLEETGKRLQF-AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN 2290
+ + EE +R + AE G +L + + + + + + E + ++ + D +
Sbjct: 2398 ----RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2453
Query: 2291 QSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQ 2350
++I +L++ KE ++E K+ + + Q ++ + + E +Q E L
Sbjct: 2454 EAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2512
Query: 2351 LDKEKAEL--IHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
+++EKA+L + Q E K Q E Q++++ + L ++ + + +E +++
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2572
Query: 2409 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELT-SPVAASE 2464
++EL+ + ++ E+L + +++ + L E+ + + E+T S VAA++
Sbjct: 2573 KQEELQQLEQQRRQQ-EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2628
Score = 145 bits (367), Expect = 4e-34
Identities = 388/1985 (19%), Positives = 766/1985 (38%), Gaps = 335/1985 (16%)
Query: 53 RITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRF 112
R+ L K A+E + E +KA E + + E L + + S
Sbjct: 1010 RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT--- 1066
Query: 113 LRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKK 172
LR+E+ +LEQ R L + LEK K ++ L +R + E LR ++LK+
Sbjct: 1067 LRSELELTLGKLEQV-RSLSAIY--LEKLKTIS--LVIRGTQGAEE--VLRAHEEQLKE- 1118
Query: 173 NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKI 232
Q + ++++ K +L R + ++ + ++ ++ DE++ E E++
Sbjct: 1119 ----AQAVPATLPELEATKASLKKLRAQ-----AEAQQPTFDALR--DELRGAQEVGERL 1167
Query: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTD---NVIDQLKKENDHYQLQVQELT 289
+ ++ E +E + E++ R +A++ QTD ++QL ++ +Y+ L
Sbjct: 1168 QQRHGERDVEVE---RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1224
Query: 290 DLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLR---EKLKNAQLDAD 346
L+ + I A + + +++ + Q +L + EK++ Q A
Sbjct: 1225 AWLQDARRRQEQIQAMPLADSQAVR-------EQLRQEQALLEEIERHGEKVEECQRFA- 1276
Query: 347 KSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEK------NTCIIEDLKNELQRNKGAST 400
K + A I++ + Q+ Q+E +K + +I++ + +T
Sbjct: 1277 KQYINA----IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1332
Query: 401 LSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDY-ESGVYGLE 459
L+ Q I TL + +E ER AE A+ RE+ E+ AL++ + E+
Sbjct: 1333 LTSQYIKFISETL----RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1388
Query: 460 DAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTE 519
A E K + +++ +E+ + E D + +++E +L +
Sbjct: 1389 QAEREAKELQQRMQ----------EEVVRREEAAVDAQQQKRSIQE----------ELQQ 1428
Query: 520 FRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQM-----AQERGKRSATSGLTT 574
R S AE Q ++ E+ E RL ++++IR + A ER + A L
Sbjct: 1429 LRQSSE-------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1481
Query: 575 EDLNLTENISQGDRISERKLDLLSLKNMSEAQSKN----EFLSRELIEKERDLERSRTVI 630
E +Q R ++ + + L + E+Q K E SR E E E+ R
Sbjct: 1482 LRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-- 1538
Query: 631 AKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNA-IESK 689
L+ L E Q EE + + QA E + + + + + +R A ++SK
Sbjct: 1539 ------LQALEELRLQAEEAERRLRQAEVERAR-------QVQVALETAQRSAEAELQSK 1585
Query: 690 NAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSL 749
A + QL +E + + R+EA +QQ A+A + E+E
Sbjct: 1586 RAS--------FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1637
Query: 750 --LRQSEGSNVVFKGIDLPD--GIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSL 805
L+ +E + + ++ +A + A + E + E + + + L +
Sbjct: 1638 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1697
Query: 806 EDYNRKFAVIRHQQSLLYKEYL----SEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEY 861
+ R+ A QQ L ++ L +E E + + + ++EE +L+ + K +E
Sbjct: 1698 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1757
Query: 862 NNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNEL 921
L ++ EM+ +LA +R E + R +EK K L
Sbjct: 1758 EAELAKVRA---EMEVLLASKARA---------------------EEESRSTSEKSKQRL 1793
Query: 922 LSMEAEVCEKIGCLQRFKEMA--IFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI 979
EAE RF+E+A ++ AL + L+E + A ++
Sbjct: 1794 ---EAEA-------GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----------- 1832
Query: 980 LQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTI-EQAWEQETKLGNES 1038
+ + +L ++ + + E LK + E KE E E+L + E Q +L ++
Sbjct: 1833 AEAERVLAEKLAAIG----EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888
Query: 1039 SMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1098
+ KA I +++ L +E +R + + E +Q+EE L+
Sbjct: 1889 AQHKA----------DIEERLAQLRKASDSELERQKG---LVEDTLRQRRQVEEEILALK 1935
Query: 1099 TKF----AELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELE----KNEMELKV 1150
F A ++ L+ ++ D L S +A +A RQR L E + E E +V
Sbjct: 1936 ASFEKAAAGKAELELELGRIRSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERV 1994
Query: 1151 EVSKLRE----------ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLI 1200
+ S E + ++ R + ++ A++ E ES R L +A +K L
Sbjct: 1995 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA--QKRLQ 2052
Query: 1201 AKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA 1260
A+ H ++Q E L+ S L ++ + +E E+A R++ A
Sbjct: 2053 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA----RVQAEREA 2108
Query: 1261 KHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLE 1320
R+ ++ R A AQ ++ Q +KL+ K E
Sbjct: 2109 AQSRRQVEEAERLKQSAEEQAQ----ARAQAQAAAEKLR-----------------KEAE 2147
Query: 1321 MELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIIS 1380
E + E + L+ + A + H K E L R+ + ++E+ L +
Sbjct: 2148 QEAARRAQAEQ-AALRQKQAADAEMEKHKKFAEQTL------RQKAQVEQELTTLRLQLE 2200
Query: 1381 EYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG 1440
E + + L+EE+ + E A QR + + E+ + + EE
Sbjct: 2201 ETDHQKNLLDEEL---QRLKAEATEAARQRS-----------QVEEELFSVRVQMEE--- 2243
Query: 1441 SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK 1500
L K+K RI E RA L++K++ R ++ + K
Sbjct: 2244 ----------------LSKLKA--RIEAENRALI------LRDKDNTQRFLQEEA-EKMK 2278
Query: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
+ E RL A+ + +L +++ + K+ + + +Q K E
Sbjct: 2279 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA----- 2333
Query: 1561 RLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF 1620
LL++ +E +E ++ +ED + +L A+ + + + +Q +
Sbjct: 2334 ELLQQQKELAQEQARRLQEDKEQMAQQL---AEETQGFQRTLEAERQRQLEMSAEAERLK 2390
Query: 1621 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHED-- 1678
+R+AEM + A ++ + +++ + L R T+ KV + +++Q Q++ D
Sbjct: 2391 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2450
Query: 1679 EVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738
+++ AE+E K L Q K Q E+Q ++ T ++ K L +E
Sbjct: 2451 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2510
Query: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENL 1798
R + + +A++ ++ + A +E QQ +++ + L +E+
Sbjct: 2511 -------RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2563
Query: 1799 LKLKEALKTS-----------KNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEN 1847
+ +E ++ + +E L + L +LQ ++ + L EE+
Sbjct: 2564 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2623
Query: 1848 DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKE 1907
+ + L G + + L+RKV Q G + +L+ + + +
Sbjct: 2624 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTV 2683
Query: 1908 ELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLT----LQRK 1963
+ + A+ E +R+ L+ + +++ L KA EKL+ LQR+
Sbjct: 2684 DEL---------ARREDVRHYLQGR-----------SSIAGLLLKATNEKLSVYAALQRQ 2723
Query: 1964 LKTTG 1968
L + G
Sbjct: 2724 LLSPG 2728
Score = 137 bits (346), Expect = 1e-31
Identities = 374/2011 (18%), Positives = 809/2011 (40%), Gaps = 281/2011 (13%)
Query: 641 VEENKQLEEG----MKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696
V+ +LE+ ++++L ++E Q D G E + +PS+E + + G+
Sbjct: 515 VQRRPELEDSTLRYLQDLLAWVEENQHRVD--GAEWGVDLPSVEAQLGS-----HRGLHQ 567
Query: 697 ASLHLKAQVDQLTGRNEELRQELRESRKEAIN-----YSQQLAKANLKIDHLE------- 744
+ +A++++ +L R + ++ + Y++ L + ++ LE
Sbjct: 568 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVA 627
Query: 745 ---KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNL 801
KE L + E V F D + ++ E L++ELE KEKK+K L
Sbjct: 628 AATKELMWLNEKEEEEVGFDWSDRNTNMT--------AKKESYSALMRELELKEKKIKEL 679
Query: 802 EDS-----LEDYNRKFAVIRHQQSL------------LYKEYLSEKETWKTESKTIKEEK 844
+++ ED+ + V Q +L + +L E + ++E +
Sbjct: 680 QNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAE 739
Query: 845 RKLEDQVQQDAIKVKEYN-------NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
+L Q Q+A++ ++Y+ L L D+ + K+ L E ++ L K+++
Sbjct: 740 GQL--QKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 796
Query: 898 ----RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953
R + L + ++ E+ + + C+ +G Q + + + V
Sbjct: 797 QLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQP-SHWKVLSSSGSEAAV 855
Query: 954 DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENI----SLKEQVES 1009
+ L + N++ E + L+ + + + H++ +++ SL+ V+
Sbjct: 856 PSVCFL--VPPPNQEAQEAVTR----LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 909
Query: 1010 INK---------ELEITKEKLHTIE---QAWEQETKLGNESSMDKAKKSITNSDIVSISK 1057
I + E ++ LH++E QA+ ++++ + + + + S S
Sbjct: 910 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQ--DAGGFGPEDRLMAEREYGSCSH 967
Query: 1058 KITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLD------- 1110
L Q CQ+ L+ Q+E ET+ ++ LD
Sbjct: 968 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE----ACETRTVHRLRLPLDKEPAREC 1023
Query: 1111 AQKV-EQMLRDELADSVSKAVS--DADRQRILELE---------KNEMELKV-EVSKLRE 1157
AQ++ EQ + + K V+ A+ +++L L ++E+EL + ++ ++R
Sbjct: 1024 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1083
Query: 1158 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA 1217
+S I +++ ++ + E LR + + + +L SL+ A A
Sbjct: 1084 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1143
Query: 1218 LGK---LESITSKLQKMEAYNLRLEQKLDEKEQALYYAR--------------LEGRNRA 1260
+ +++ +L+ + RL+Q+ E++ + R + R
Sbjct: 1144 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1203
Query: 1261 KHLRQTIQSLRRQFSGALPLA---QQEKFSKTMIQLQ--NDKLKIMQEMKNSQQEHRNME 1315
+ L Q + LR A PL Q + + IQ D + ++++ Q +E
Sbjct: 1204 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1263
Query: 1316 NKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELK---------LNRELV 1366
++E + ++ I+ +KD + +++ + ++E + K + +E V
Sbjct: 1264 RHGEKVEECQRFAKQYINAIKDYE--LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1321
Query: 1367 KDKEEIKYLNNIISEYERTISSL------EEEIVQQNKFHEERQMAWDQREVDLERQLDI 1420
+ L + S+Y + IS EE + +Q + E ++A + E LE+Q +
Sbjct: 1322 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQL 1379
Query: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEK 1480
+ A ++ +E + + + + E A+ ++ I E + +S E +
Sbjct: 1380 AEAHAQAKAQAEREAKELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1436
Query: 1481 LKEKESALRLAEQNILSRDKVINELRLRLPAT------AEREKLIAELGRKEMEPKSHHT 1534
++ K AE++ L ++ I +RL+L AT AE E +E E +
Sbjct: 1437 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1496
Query: 1535 LKIAHQTIANMQARLNQKE----EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 1590
+ A + +Q +K E+ + + E ARE+QR + E L L
Sbjct: 1497 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---------LRL 1547
Query: 1591 QADSSLNKFKQTAWDLMKQSPTPVPTNKHFI------RLAEMEQTVAEQDDSLSSLLVKL 1644
QA+ + + +Q + +Q + T + + A + A+ + SL V +
Sbjct: 1548 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1607
Query: 1645 KKVSQDLER--QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDL--KYLLDQSQKE 1700
++ ++ ER Q++ + +E +L+ + +E +++ + E++ + L Q++ E
Sbjct: 1608 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667
Query: 1701 SQCLKSELQAQKEANSRAPTTTMRNLVER-LKSQLALKE---KQQKALSRALLELRAEMT 1756
Q ++E +A++ + R L E+ L+ Q L E +Q+ A + L+ LRAE
Sbjct: 1668 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1727
Query: 1757 AAAEERII----SATSQKEAHLNVQ--QIVDRHTRELKTQVEDLNENLLKLKEALKT--- 1807
++R + A Q+EA Q Q ++ +++ ++E L + + +E ++
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1787
Query: 1808 -SKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPL 1866
SK R + +L E + + + R+++ +++ + + +R+ +
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA------- 1840
Query: 1867 TDNKQSLIEELQRKVKKLENQL-EGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIE-- 1923
K + I E R + E L E + E L+ + E A + E+ + +A IE
Sbjct: 1841 --EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1898
Query: 1924 ------GIRNKLKEKEGEVFTLTKQ-------LNTLKDLFAKADKEKLTLQRKLKTTGMT 1970
++L+ ++G V +Q + LK F KA K L+ +L
Sbjct: 1899 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1958
Query: 1971 VDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLH 2030
+ L + + ELE ++R L E + A + + + E+ + R + L
Sbjct: 1959 AEDTL---RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALE 2013
Query: 2031 ALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQ-ANKDLPRL 2089
+E+ +K E+ +R ++ L+L+ E + + Q E+ A+ +
Sbjct: 2014 EVERLKAKVE---------EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2064
Query: 2090 KNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENE 2149
K Q E+ + L++E++ + + G + R+ + E +VQ E E
Sbjct: 2065 KEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------------ARVQAERE 2107
Query: 2150 QLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERL 2209
+ + +E++ +E + +A+ + L + + + + + + +
Sbjct: 2108 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2167
Query: 2210 RKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETG--KRLQFAESRGPQLEGADSKSWK 2267
E++K AE+ K +E + +QLEET K L E + + E ++ +
Sbjct: 2168 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2227
Query: 2268 SIVVTRMYETK-----LKELETDIAKKNQSITDLKQLVKEATER--EQKVNKYNEDLEQQ 2320
S V ++ + L +L+ I +N+++ L+ K+ T+R +++ K + E+
Sbjct: 2228 SQVEEELFSVRVQMEELSKLKARIEAENRALI-LRD--KDNTQRFLQEEAEKMKQVAEEA 2284
Query: 2321 IKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQ 2380
++ E A Q + +L R ++ KEK + + EA + ++ AE +
Sbjct: 2285 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKEL 2342
Query: 2381 LKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFE---EIEDLKYNYKEEVKK 2437
+E+ + L+ + Q L EE + ++ LE E E E LK E +
Sbjct: 2343 AQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2399
Query: 2438 NILLEE---KVKKLSEQLGVELTSPVAASEE 2465
EE + +K +E++G +L A++E
Sbjct: 2400 QARAEEDAQRFRKQAEEIGEKLHRTELATQE 2430
Score = 130 bits (327), Expect = 2e-29
Identities = 247/1349 (18%), Positives = 554/1349 (41%), Gaps = 139/1349 (10%)
Query: 39 ELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL 98
E EKQ + ++ + +A+E++ ++E EE A Q K + + +L
Sbjct: 1370 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1429
Query: 99 EMA----------QQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQL 148
+ Q A R + EI + QLE +R+ E EL+ + E+
Sbjct: 1430 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1489
Query: 149 ALRNEEAENENSKLRR----ENKRLKKKNEQLCQDI-------IDYQKQIDSQKETLLSR 197
+ +A+ E +LRR E++R ++ +L + + Q+ + + +E L
Sbjct: 1490 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1549
Query: 198 RGEDSDYRSQLSKKNYELIQYLDEIQTLTEAN-EKIEVQNQEMRKNLEESVQE----MEK 252
+ R ++ ++ L+ Q EA + E LE S+QE + +
Sbjct: 1550 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1609
Query: 253 MTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDL-LKSKNEEDDPIMVAVNAKVE 311
+ +E R + + ++ ++E + +QL+ E L L+++ + A+ +
Sbjct: 1610 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1669
Query: 312 EWKLILSSK-----DDEIIEYQQMLHNLREKLKN------AQLDADKSNVMALQQGIQER 360
+ + ++ +++ + +++ EK + Q A + ++ L+ ++
Sbjct: 1670 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1729
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQR---------------NKGASTLSQQT 405
+ Q ++L E++ + +E T ++L+ EL + + + + S+++
Sbjct: 1730 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1789
Query: 406 HMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEI 465
++++ +E +EA R LAE R++ +A ++ + E + A+ E
Sbjct: 1790 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1849
Query: 466 KNCKNQIKIRDREIEILTKEINKL--ELKISDFLDENEALRERVGLEPKTMIDLTEFRNS 523
K + +I +E E + + +L + E +A + + +E + L + R +
Sbjct: 1850 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKA 1905
Query: 524 KHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSG---LTTEDLNLT 580
+ ++ + + L++ +EEE L LK + A + + G ED +
Sbjct: 1906 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965
Query: 581 ENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKEL 640
+ ++ + +R+L + EA+ + ++ + E + R R + +LK
Sbjct: 1966 KEQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAK 2021
Query: 641 VEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLH 700
VEE ++L E ++ ++ +++Q E + E +A + E +L
Sbjct: 2022 VEEARRLRERAEQ--ESARQLQ-----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2074
Query: 701 LKAQV-DQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVV 759
+ V DQL G E R+ E+ + + ++ A++ +++ E+ L+QS
Sbjct: 2075 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER----LKQSAEEQAQ 2130
Query: 760 FKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQ 819
+ A ++A + + E + E + K D+ + ++KFA +Q
Sbjct: 2131 AR------AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184
Query: 820 SLLYKEYLS----EKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEM 875
++ L+ + E + + EE ++L+ + + A + + L ++++ +E+
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2244
Query: 876 KKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEA----EVCEK 931
K+ A + L + +K +++ E E+ + E + + + EA ++ E+
Sbjct: 2245 SKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2303
Query: 932 IGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTS 991
QR + K +Q V + + +E EL +Q EL + LQ+D + +
Sbjct: 2304 DLAQQRALAEKMLK-EKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQL 2361
Query: 992 NLEHLECENISLKEQVESINKELEITKEKLHTIE----QAWEQETKLGNESSMDKAKKSI 1047
E + E+ + E + KL E QA +E ++ + +
Sbjct: 2362 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2421
Query: 1048 TNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFEL--ETKFAELT 1105
+++ + +K+T+++ E+ +RQ+++H E LR ++ ++E +L E K +L
Sbjct: 2422 HRTELAT-QEKVTLVQTLEI-QRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLK 2476
Query: 1106 KINLDAQKVEQMLRDELA---DSVSKAVSDADRQRILELEKNEME--LKVEVSKLREISD 1160
+ + EQ+L++ A +S+ S R+R +E EK ++E + EV+K +++ +
Sbjct: 2477 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2536
Query: 1161 IARRQVEILNAQQQSRDKEVESLR----------------MQLLDYQAQSDEKSLIAKLH 1204
+RQ + + ++Q +E R +Q L+ Q + E+ L +
Sbjct: 2537 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2596
Query: 1205 QHNVSLQLSE---ATALGKLESITSKLQKMEAYNLRLEQKLDEKEQAL--YYARLEGRNR 1259
+ LQL E AL E +T A + + L AL A E +
Sbjct: 2597 RLREQLQLLEEQHRAALAHSEEVT-------ASQVAATKTLPNGRDALDGPAAEAEPEHS 2649
Query: 1260 AKHLRQTIQSLRRQFSGALPLAQQEKFSK 1288
LR+ + + R Q +G L + ++ ++
Sbjct: 2650 FDGLRRKVSAQRLQEAGILSAEELQRLAQ 2678
Score = 53.9 bits (128), Expect = 2e-06
Identities = 233/1241 (18%), Positives = 475/1241 (38%), Gaps = 202/1241 (16%)
Query: 1353 ELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEE--RQMAWD-- 1408
+L + L+ ++L + E ++ L I+++ + EE++ Q + + R +A
Sbjct: 376 KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKV 435
Query: 1409 -QREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRII 1467
QR ++ER LD D + N Q ++ + +L L I+ +
Sbjct: 436 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 495
Query: 1468 LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLI------AE 1521
L+ + + +S R E D + L+ L E + + +
Sbjct: 496 LKAGVAAPATQVAQVTLQSVQRRPELE----DSTLRYLQDLLAWVEENQHRVDGAEWGVD 551
Query: 1522 LGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDL 1581
L E + SH L HQ+I +A++ E+AR ++ ++
Sbjct: 552 LPSVEAQLGSHRGL---HQSIEEFRAKI--------------ERARSDEGQLSPATRGAY 594
Query: 1582 HILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLL 1641
RL+LQ LN K L K + L E E+ D S +
Sbjct: 595 RDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 654
Query: 1642 VKLKKVSQD-LERQREITELKVKEFEN--------------------------------- 1667
+ KK S L R+ E+ E K+KE +N
Sbjct: 655 MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 714
Query: 1668 ---IKLQLQENHE-----DEVKKVKAEVEDL------KYLLDQSQKESQC--LKSELQAQ 1711
I+ L+EN +V++ + +++ L KY D+S ++ L + Q +
Sbjct: 715 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 774
Query: 1712 KEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRA-----------------E 1754
KE + + L +R K+ + LK + R L L A +
Sbjct: 775 KEQLNEYKGH-LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQ 833
Query: 1755 MTAAAEE---RIISATSQKEAHLNVQQIV---DRHTRELKTQVEDLNENLLKLKEALKT- 1807
+ A+ +++S++ + A +V +V ++ +E T++E ++ L+ L L
Sbjct: 834 LVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 893
Query: 1808 --------SKNRENSL----------TDNLNDLNNELQKKQKAYNKILREKEEI------ 1843
S R+ L T + L + Y LR+ ++
Sbjct: 894 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 953
Query: 1844 -----DQENDELKRQIKRLTSGL-QGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDL 1897
++E ++L L QG Q I EL+ +LE V + L
Sbjct: 954 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1013
Query: 1898 KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEK 1957
P+ ++ A+E R E +K QA++EG+ + E +++ L + A
Sbjct: 1014 -PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA----EKVLALPEPSPAAP--- 1065
Query: 1958 LTLQRKLKTTGMTVDQVLGIRALESEK-ELEELKKRNLDLENDILYMRAHQALPRDSVVE 2016
TL+ +L+ T ++QV + A+ EK + L R ++L RAH+ +++
Sbjct: 1066 -TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL--RAHEEQLKEAQAV 1122
Query: 2017 DLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELK 2076
L L+ +L+K ++ +P+ + D + QE+ + +L + E
Sbjct: 1123 PATLPE--LEATKASLKKLRAQAEAQQPTFDALR--DELRGAQEVGE---RLQQRHGERD 1175
Query: 2077 FQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS-GKTIPELEKTIG 2135
++E+ + + +L + + + + ++E ++ R+L + R S G + + +
Sbjct: 1176 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1235
Query: 2136 LMKKV-VEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG--HQLSMHY 2192
++ + + Q EQL++ +L IE+ EK++ K ++ +
Sbjct: 1236 QIQAMPLADSQAVREQLRQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQL 1290
Query: 2193 ESKTKGTEKIIAENERLRKELKKETDAAE--KLRIAKNNLEILNEKMTVQLEETGKRLQF 2250
+ E + + ++ + + E+ E LR + L L + + ET +R++
Sbjct: 1291 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1350
Query: 2251 AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKV 2310
E Q + + +L E+E + K+ Q + + K ERE K
Sbjct: 1351 EERLAEQQRAEERE-------------RLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKE 1396
Query: 2311 NKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSG 2370
+ E+ ++ + + + ++ ++ ELQ LR ++ +AE+ Q +A + ++
Sbjct: 1397 LQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQSS------EAEI--QAKARQAEAA 1447
Query: 2371 AESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYN 2430
S + +++E+I+ + QL+ ++ ++ + E++ L+ E E E K
Sbjct: 1448 ERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQALRARAE--------EAEAQKRQ 1495
Query: 2431 YKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEE 2471
+EE ++ + + Q VEL S V A E E++
Sbjct: 1496 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1536
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 171 bits (433), Expect = 8e-42
Identities = 351/1737 (20%), Positives = 727/1737 (41%), Gaps = 210/1737 (12%)
Query: 861 YNNLLNALQMDSDEMKKILAENSR-KITVLQVNEKSLIRQYTTLVELERQLRKENEKQKN 919
Y LL +L+ + E + S K LQ+ + + L+++ +E ++
Sbjct: 965 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1024
Query: 920 ELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSL-SELELAN---KQYNELTAK 975
E +AEV E +G K+ AL + + +L SELEL +Q L+A
Sbjct: 1025 EQQKAQAEV-EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1083
Query: 976 YRDILQKDNMLVQRTSNLEH-LECENISLKEQ--VESINKELEITKEKLHTIEQAWEQET 1032
Y + L+ +++++ T E L LKE V + ELE TK L + E +
Sbjct: 1084 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ- 1142
Query: 1033 KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE 1092
+ + D + + + V + E ER R E ++ E + L Q +
Sbjct: 1143 ----QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDV 1197
Query: 1093 RNFELETKFAELTKINLDAQKVEQMLRD-ELADSVSKAVSDADRQRILELEKNEMELKVE 1151
R ELE +L A + L+D +A+ AD Q + E + E L E
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 1152 VSKLRE-ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSD------EKSLIAKLH 1204
+ + E + + R + +NA ++ +QL+ Y+AQ + +K +
Sbjct: 1258 IERHGEKVEECQRFAKQYINA--------IKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1309
Query: 1205 QHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLR 1264
+ + + T +L ++TS+ K + LR +++E+E+ R E R R +
Sbjct: 1310 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERERLAEVE 1366
Query: 1265 QTIQSLRRQFSG-ALPLAQQEKFSKTMIQ-LQNDKLKIMQEMKNSQQEHRNMENKTLEME 1322
++ R+ A AQ E+ +K + Q +Q + ++ + ++QQ+ R+++ + +
Sbjct: 1367 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL--QQ 1424
Query: 1323 LKLKGLEELISTLKDTKGAQKVINWHMKIEE----LRLQELKLNRELVKDKEEIKYLNNI 1378
L+ E+ + + + A++ ++IEE +RLQ R+ + E++ L
Sbjct: 1425 LRQSSEAEIQAKARQAEAAERS---RLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1481
Query: 1379 ISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDI---FDRQQNEILNAAQKF 1435
E E +EE + + ++ Q EV+L ++ R++ L A ++
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541
Query: 1436 ----EEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLA 1491
EEA + + Q+++AL + + L+++ S EK + E +L+
Sbjct: 1542 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA--SFAEKTAQLERSLQ-E 1598
Query: 1492 EQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQ 1551
E +++ + E R + A AER + AE + + K++ L++ Q Q Q
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ----Q 1654
Query: 1552 KEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSP 1611
K + ++ E+A E R K E+ + R A+ L K +Q A +Q
Sbjct: 1655 KSLAQAEAEKQKEEAEREARRRGKAEEQAV-----RQRELAEQELEKQRQLAEGTAQQ-- 1707
Query: 1612 TPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFEN---I 1668
RLA AEQ+ L++L+ ++ E+QR++ E ++ +
Sbjct: 1708 ----------RLA------AEQE------LIRLRAETEQGEQQRQLLEEELARLQREAAA 1745
Query: 1669 KLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANS------RAPTTT 1722
Q ++ E E+ KV+AE+E L ++++ES+ + + + EA +
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1805
Query: 1723 MRNLVERLKSQLALKE----KQQKALSRALLELRA---EMTAAAEERIISATSQKEAHLN 1775
+R L E K Q L E +Q+ R L E A E T E I+ ++ +
Sbjct: 1806 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1865
Query: 1776 VQQIVDRHT---RELKTQVE----DLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQK 1828
++++ + R L+ Q D+ E L +L++A + R+ L ++ L++
Sbjct: 1866 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------LRQ 1919
Query: 1829 KQKAYNKILREKEEIDQE---NDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE 1885
+++ +IL K ++ EL+ ++ R+ S + + + L QR++ E
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1979
Query: 1886 NQLEGKVEEVDLKPM--KEKNAKEELIRWEEGKKWQAKIEG---IRNKLKEKEGEVFTLT 1940
+ + EE K + +E+ A++ EE ++ +AK+E +R + +++ L
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 1941 K-------QLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGI---------------- 1977
+ Q FA KE+ LQ+ L+ +DQ+ G
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2098
Query: 1978 ----RALESEKELEELKKRNLDLENDI------------LYMRAHQALPRDSVVEDLHLQ 2021
A +S +++EE ++ E L A Q R + E L+
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158
Query: 2022 NRYLQEKLHALEKQFSKDTY-SKPSISG--------IESDDHCQR--EQELQK------- 2063
+ + K+F++ T K + +E DH + ++ELQ+
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 2064 ---ENLKLSSENIELKFQLEQANKDLPRLKNQ-----VRDLKEMCEFLKKEKA---EVQR 2112
+ ++ E ++ Q+E+ +K R++ + +RD FL++E +V
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2278
Query: 2113 KLGHVRGSGRSGKTIPEL-EKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171
+ + + + + +L E+ + + + EK+ +E Q + + L +E A + Q+ +
Sbjct: 2279 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQK 2336
Query: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLE 2231
+L E + Q++ +T+G ++ + + + E+ E + KLR+A+ +
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMS-- 2393
Query: 2232 ILNEKMTVQLEETGKRLQF-AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN 2290
+ + EE +R + AE G +L + + + + + + E + ++ + D +
Sbjct: 2394 ----RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2449
Query: 2291 QSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQ 2350
++I +L++ KE ++E K+ + + Q ++ + + E +Q E L
Sbjct: 2450 EAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2508
Query: 2351 LDKEKAEL--IHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
+++EKA+L + Q E K Q E Q++++ + L ++ + + +E +++
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 2409 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELT-SPVAASE 2464
++EL+ + ++ E+L + +++ + L E+ + + E+T S VAA++
Sbjct: 2569 KQEELQQLEQQRRQQ-EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624
Score = 145 bits (367), Expect = 4e-34
Identities = 388/1985 (19%), Positives = 766/1985 (38%), Gaps = 335/1985 (16%)
Query: 53 RITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRF 112
R+ L K A+E + E +KA E + + E L + + S
Sbjct: 1006 RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT--- 1062
Query: 113 LRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKK 172
LR+E+ +LEQ R L + LEK K ++ L +R + E LR ++LK+
Sbjct: 1063 LRSELELTLGKLEQV-RSLSAIY--LEKLKTIS--LVIRGTQGAEE--VLRAHEEQLKE- 1114
Query: 173 NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKI 232
Q + ++++ K +L R + ++ + ++ ++ DE++ E E++
Sbjct: 1115 ----AQAVPATLPELEATKASLKKLRAQ-----AEAQQPTFDALR--DELRGAQEVGERL 1163
Query: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTD---NVIDQLKKENDHYQLQVQELT 289
+ ++ E +E + E++ R +A++ QTD ++QL ++ +Y+ L
Sbjct: 1164 QQRHGERDVEVE---RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1220
Query: 290 DLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLR---EKLKNAQLDAD 346
L+ + I A + + +++ + Q +L + EK++ Q A
Sbjct: 1221 AWLQDARRRQEQIQAMPLADSQAVR-------EQLRQEQALLEEIERHGEKVEECQRFA- 1272
Query: 347 KSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEK------NTCIIEDLKNELQRNKGAST 400
K + A I++ + Q+ Q+E +K + +I++ + +T
Sbjct: 1273 KQYINA----IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1328
Query: 401 LSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDY-ESGVYGLE 459
L+ Q I TL + +E ER AE A+ RE+ E+ AL++ + E+
Sbjct: 1329 LTSQYIKFISETL----RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1384
Query: 460 DAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTE 519
A E K + +++ +E+ + E D + +++E +L +
Sbjct: 1385 QAEREAKELQQRMQ----------EEVVRREEAAVDAQQQKRSIQE----------ELQQ 1424
Query: 520 FRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQM-----AQERGKRSATSGLTT 574
R S AE Q ++ E+ E RL ++++IR + A ER + A L
Sbjct: 1425 LRQSSE-------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477
Query: 575 EDLNLTENISQGDRISERKLDLLSLKNMSEAQSKN----EFLSRELIEKERDLERSRTVI 630
E +Q R ++ + + L + E+Q K E SR E E E+ R
Sbjct: 1478 LRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-- 1534
Query: 631 AKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNA-IESK 689
L+ L E Q EE + + QA E + + + + + +R A ++SK
Sbjct: 1535 ------LQALEELRLQAEEAERRLRQAEVERAR-------QVQVALETAQRSAEAELQSK 1581
Query: 690 NAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSL 749
A + QL +E + + R+EA +QQ A+A + E+E
Sbjct: 1582 RAS--------FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1633
Query: 750 --LRQSEGSNVVFKGIDLPD--GIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSL 805
L+ +E + + ++ +A + A + E + E + + + L +
Sbjct: 1634 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1693
Query: 806 EDYNRKFAVIRHQQSLLYKEYL----SEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEY 861
+ R+ A QQ L ++ L +E E + + + ++EE +L+ + K +E
Sbjct: 1694 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1753
Query: 862 NNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNEL 921
L ++ EM+ +LA +R E + R +EK K L
Sbjct: 1754 EAELAKVRA---EMEVLLASKARA---------------------EEESRSTSEKSKQRL 1789
Query: 922 LSMEAEVCEKIGCLQRFKEMA--IFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI 979
EAE RF+E+A ++ AL + L+E + A ++
Sbjct: 1790 ---EAEA-------GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----------- 1828
Query: 980 LQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTI-EQAWEQETKLGNES 1038
+ + +L ++ + + E LK + E KE E E+L + E Q +L ++
Sbjct: 1829 AEAERVLAEKLAAIG----EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 1039 SMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1098
+ KA I +++ L +E +R + + E +Q+EE L+
Sbjct: 1885 AQHKA----------DIEERLAQLRKASDSELERQKG---LVEDTLRQRRQVEEEILALK 1931
Query: 1099 TKF----AELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELE----KNEMELKV 1150
F A ++ L+ ++ D L S +A +A RQR L E + E E +V
Sbjct: 1932 ASFEKAAAGKAELELELGRIRSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERV 1990
Query: 1151 EVSKLRE----------ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLI 1200
+ S E + ++ R + ++ A++ E ES R L +A +K L
Sbjct: 1991 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA--QKRLQ 2048
Query: 1201 AKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA 1260
A+ H ++Q E L+ S L ++ + +E E+A R++ A
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA----RVQAEREA 2104
Query: 1261 KHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLE 1320
R+ ++ R A AQ ++ Q +KL+ K E
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQ----ARAQAQAAAEKLR-----------------KEAE 2143
Query: 1321 MELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIIS 1380
E + E + L+ + A + H K E L R+ + ++E+ L +
Sbjct: 2144 QEAARRAQAEQ-AALRQKQAADAEMEKHKKFAEQTL------RQKAQVEQELTTLRLQLE 2196
Query: 1381 EYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG 1440
E + + L+EE+ + E A QR + + E+ + + EE
Sbjct: 2197 ETDHQKNLLDEEL---QRLKAEATEAARQRS-----------QVEEELFSVRVQMEE--- 2239
Query: 1441 SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK 1500
L K+K RI E RA L++K++ R ++ + K
Sbjct: 2240 ----------------LSKLKA--RIEAENRALI------LRDKDNTQRFLQEEA-EKMK 2274
Query: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
+ E RL A+ + +L +++ + K+ + + +Q K E
Sbjct: 2275 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA----- 2329
Query: 1561 RLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF 1620
LL++ +E +E ++ +ED + +L A+ + + + +Q +
Sbjct: 2330 ELLQQQKELAQEQARRLQEDKEQMAQQL---AEETQGFQRTLEAERQRQLEMSAEAERLK 2386
Query: 1621 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHED-- 1678
+R+AEM + A ++ + +++ + L R T+ KV + +++Q Q++ D
Sbjct: 2387 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2446
Query: 1679 EVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738
+++ AE+E K L Q K Q E+Q ++ T ++ K L +E
Sbjct: 2447 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2506
Query: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENL 1798
R + + +A++ ++ + A +E QQ +++ + L +E+
Sbjct: 2507 -------RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2559
Query: 1799 LKLKEALKTS-----------KNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEN 1847
+ +E ++ + +E L + L +LQ ++ + L EE+
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Query: 1848 DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKE 1907
+ + L G + + L+RKV Q G + +L+ + + +
Sbjct: 2620 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTV 2679
Query: 1908 ELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLT----LQRK 1963
+ + A+ E +R+ L+ + +++ L KA EKL+ LQR+
Sbjct: 2680 DEL---------ARREDVRHYLQGR-----------SSIAGLLLKATNEKLSVYAALQRQ 2719
Query: 1964 LKTTG 1968
L + G
Sbjct: 2720 LLSPG 2724
Score = 137 bits (346), Expect = 1e-31
Identities = 374/2011 (18%), Positives = 809/2011 (40%), Gaps = 281/2011 (13%)
Query: 641 VEENKQLEEG----MKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696
V+ +LE+ ++++L ++E Q D G E + +PS+E + + G+
Sbjct: 511 VQRRPELEDSTLRYLQDLLAWVEENQHRVD--GAEWGVDLPSVEAQLGS-----HRGLHQ 563
Query: 697 ASLHLKAQVDQLTGRNEELRQELRESRKEAIN-----YSQQLAKANLKIDHLE------- 744
+ +A++++ +L R + ++ + Y++ L + ++ LE
Sbjct: 564 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVA 623
Query: 745 ---KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNL 801
KE L + E V F D + ++ E L++ELE KEKK+K L
Sbjct: 624 AATKELMWLNEKEEEEVGFDWSDRNTNMT--------AKKESYSALMRELELKEKKIKEL 675
Query: 802 EDS-----LEDYNRKFAVIRHQQSL------------LYKEYLSEKETWKTESKTIKEEK 844
+++ ED+ + V Q +L + +L E + ++E +
Sbjct: 676 QNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAE 735
Query: 845 RKLEDQVQQDAIKVKEYN-------NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
+L Q Q+A++ ++Y+ L L D+ + K+ L E ++ L K+++
Sbjct: 736 GQL--QKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 792
Query: 898 ----RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953
R + L + ++ E+ + + C+ +G Q + + + V
Sbjct: 793 QLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQP-SHWKVLSSSGSEAAV 851
Query: 954 DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENI----SLKEQVES 1009
+ L + N++ E + L+ + + + H++ +++ SL+ V+
Sbjct: 852 PSVCFL--VPPPNQEAQEAVTR----LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 905
Query: 1010 INK---------ELEITKEKLHTIE---QAWEQETKLGNESSMDKAKKSITNSDIVSISK 1057
I + E ++ LH++E QA+ ++++ + + + + S S
Sbjct: 906 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQ--DAGGFGPEDRLMAEREYGSCSH 963
Query: 1058 KITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLD------- 1110
L Q CQ+ L+ Q+E ET+ ++ LD
Sbjct: 964 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE----ACETRTVHRLRLPLDKEPAREC 1019
Query: 1111 AQKV-EQMLRDELADSVSKAVS--DADRQRILELE---------KNEMELKV-EVSKLRE 1157
AQ++ EQ + + K V+ A+ +++L L ++E+EL + ++ ++R
Sbjct: 1020 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1079
Query: 1158 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA 1217
+S I +++ ++ + E LR + + + +L SL+ A A
Sbjct: 1080 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1139
Query: 1218 LGK---LESITSKLQKMEAYNLRLEQKLDEKEQALYYAR--------------LEGRNRA 1260
+ +++ +L+ + RL+Q+ E++ + R + R
Sbjct: 1140 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1199
Query: 1261 KHLRQTIQSLRRQFSGALPLA---QQEKFSKTMIQLQ--NDKLKIMQEMKNSQQEHRNME 1315
+ L Q + LR A PL Q + + IQ D + ++++ Q +E
Sbjct: 1200 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1259
Query: 1316 NKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELK---------LNRELV 1366
++E + ++ I+ +KD + +++ + ++E + K + +E V
Sbjct: 1260 RHGEKVEECQRFAKQYINAIKDYE--LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1317
Query: 1367 KDKEEIKYLNNIISEYERTISSL------EEEIVQQNKFHEERQMAWDQREVDLERQLDI 1420
+ L + S+Y + IS EE + +Q + E ++A + E LE+Q +
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQL 1375
Query: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEK 1480
+ A ++ +E + + + + E A+ ++ I E + +S E +
Sbjct: 1376 AEAHAQAKAQAEREAKELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1432
Query: 1481 LKEKESALRLAEQNILSRDKVINELRLRLPAT------AEREKLIAELGRKEMEPKSHHT 1534
++ K AE++ L ++ I +RL+L AT AE E +E E +
Sbjct: 1433 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1492
Query: 1535 LKIAHQTIANMQARLNQKE----EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 1590
+ A + +Q +K E+ + + E ARE+QR + E L L
Sbjct: 1493 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---------LRL 1543
Query: 1591 QADSSLNKFKQTAWDLMKQSPTPVPTNKHFI------RLAEMEQTVAEQDDSLSSLLVKL 1644
QA+ + + +Q + +Q + T + + A + A+ + SL V +
Sbjct: 1544 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1603
Query: 1645 KKVSQDLER--QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDL--KYLLDQSQKE 1700
++ ++ ER Q++ + +E +L+ + +E +++ + E++ + L Q++ E
Sbjct: 1604 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663
Query: 1701 SQCLKSELQAQKEANSRAPTTTMRNLVER-LKSQLALKE---KQQKALSRALLELRAEMT 1756
Q ++E +A++ + R L E+ L+ Q L E +Q+ A + L+ LRAE
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723
Query: 1757 AAAEERII----SATSQKEAHLNVQ--QIVDRHTRELKTQVEDLNENLLKLKEALKT--- 1807
++R + A Q+EA Q Q ++ +++ ++E L + + +E ++
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 1808 -SKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPL 1866
SK R + +L E + + + R+++ +++ + + +R+ +
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA------- 1836
Query: 1867 TDNKQSLIEELQRKVKKLENQL-EGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIE-- 1923
K + I E R + E L E + E L+ + E A + E+ + +A IE
Sbjct: 1837 --EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1894
Query: 1924 ------GIRNKLKEKEGEVFTLTKQ-------LNTLKDLFAKADKEKLTLQRKLKTTGMT 1970
++L+ ++G V +Q + LK F KA K L+ +L
Sbjct: 1895 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1954
Query: 1971 VDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLH 2030
+ L + + ELE ++R L E + A + + + E+ + R + L
Sbjct: 1955 AEDTL---RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALE 2009
Query: 2031 ALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQ-ANKDLPRL 2089
+E+ +K E+ +R ++ L+L+ E + + Q E+ A+ +
Sbjct: 2010 EVERLKAKVE---------EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 2090 KNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENE 2149
K Q E+ + L++E++ + + G + R+ + E +VQ E E
Sbjct: 2061 KEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------------ARVQAERE 2103
Query: 2150 QLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERL 2209
+ + +E++ +E + +A+ + L + + + + + + +
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2163
Query: 2210 RKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETG--KRLQFAESRGPQLEGADSKSWK 2267
E++K AE+ K +E + +QLEET K L E + + E ++ +
Sbjct: 2164 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2223
Query: 2268 SIVVTRMYETK-----LKELETDIAKKNQSITDLKQLVKEATER--EQKVNKYNEDLEQQ 2320
S V ++ + L +L+ I +N+++ L+ K+ T+R +++ K + E+
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALI-LRD--KDNTQRFLQEEAEKMKQVAEEA 2280
Query: 2321 IKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQ 2380
++ E A Q + +L R ++ KEK + + EA + ++ AE +
Sbjct: 2281 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKEL 2338
Query: 2381 LKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFE---EIEDLKYNYKEEVKK 2437
+E+ + L+ + Q L EE + ++ LE E E E LK E +
Sbjct: 2339 AQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395
Query: 2438 NILLEE---KVKKLSEQLGVELTSPVAASEE 2465
EE + +K +E++G +L A++E
Sbjct: 2396 QARAEEDAQRFRKQAEEIGEKLHRTELATQE 2426
Score = 130 bits (327), Expect = 2e-29
Identities = 247/1349 (18%), Positives = 554/1349 (41%), Gaps = 139/1349 (10%)
Query: 39 ELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL 98
E EKQ + ++ + +A+E++ ++E EE A Q K + + +L
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425
Query: 99 EMA----------QQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQL 148
+ Q A R + EI + QLE +R+ E EL+ + E+
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485
Query: 149 ALRNEEAENENSKLRR----ENKRLKKKNEQLCQDI-------IDYQKQIDSQKETLLSR 197
+ +A+ E +LRR E++R ++ +L + + Q+ + + +E L
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1545
Query: 198 RGEDSDYRSQLSKKNYELIQYLDEIQTLTEAN-EKIEVQNQEMRKNLEESVQE----MEK 252
+ R ++ ++ L+ Q EA + E LE S+QE + +
Sbjct: 1546 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1605
Query: 253 MTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDL-LKSKNEEDDPIMVAVNAKVE 311
+ +E R + + ++ ++E + +QL+ E L L+++ + A+ +
Sbjct: 1606 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
Query: 312 EWKLILSSK-----DDEIIEYQQMLHNLREKLKN------AQLDADKSNVMALQQGIQER 360
+ + ++ +++ + +++ EK + Q A + ++ L+ ++
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQR---------------NKGASTLSQQT 405
+ Q ++L E++ + +E T ++L+ EL + + + + S+++
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 406 HMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEI 465
++++ +E +EA R LAE R++ +A ++ + E + A+ E
Sbjct: 1786 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1845
Query: 466 KNCKNQIKIRDREIEILTKEINKL--ELKISDFLDENEALRERVGLEPKTMIDLTEFRNS 523
K + +I +E E + + +L + E +A + + +E + L + R +
Sbjct: 1846 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKA 1901
Query: 524 KHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSG---LTTEDLNLT 580
+ ++ + + L++ +EEE L LK + A + + G ED +
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 581 ENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKEL 640
+ ++ + +R+L + EA+ + ++ + E + R R + +LK
Sbjct: 1962 KEQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 641 VEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLH 700
VEE ++L E ++ ++ +++Q E + E +A + E +L
Sbjct: 2018 VEEARRLRERAEQ--ESARQLQ-----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2070
Query: 701 LKAQV-DQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVV 759
+ V DQL G E R+ E+ + + ++ A++ +++ E+ L+QS
Sbjct: 2071 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER----LKQSAEEQAQ 2126
Query: 760 FKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQ 819
+ A ++A + + E + E + K D+ + ++KFA +Q
Sbjct: 2127 AR------AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 820 SLLYKEYLS----EKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEM 875
++ L+ + E + + EE ++L+ + + A + + L ++++ +E+
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2240
Query: 876 KKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEA----EVCEK 931
K+ A + L + +K +++ E E+ + E + + + EA ++ E+
Sbjct: 2241 SKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2299
Query: 932 IGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTS 991
QR + K +Q V + + +E EL +Q EL + LQ+D + +
Sbjct: 2300 DLAQQRALAEKMLK-EKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQL 2357
Query: 992 NLEHLECENISLKEQVESINKELEITKEKLHTIE----QAWEQETKLGNESSMDKAKKSI 1047
E + E+ + E + KL E QA +E ++ + +
Sbjct: 2358 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2417
Query: 1048 TNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFEL--ETKFAELT 1105
+++ + +K+T+++ E+ +RQ+++H E LR ++ ++E +L E K +L
Sbjct: 2418 HRTELAT-QEKVTLVQTLEI-QRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLK 2472
Query: 1106 KINLDAQKVEQMLRDELA---DSVSKAVSDADRQRILELEKNEME--LKVEVSKLREISD 1160
+ + EQ+L++ A +S+ S R+R +E EK ++E + EV+K +++ +
Sbjct: 2473 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2532
Query: 1161 IARRQVEILNAQQQSRDKEVESLR----------------MQLLDYQAQSDEKSLIAKLH 1204
+RQ + + ++Q +E R +Q L+ Q + E+ L +
Sbjct: 2533 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2592
Query: 1205 QHNVSLQLSE---ATALGKLESITSKLQKMEAYNLRLEQKLDEKEQAL--YYARLEGRNR 1259
+ LQL E AL E +T A + + L AL A E +
Sbjct: 2593 RLREQLQLLEEQHRAALAHSEEVT-------ASQVAATKTLPNGRDALDGPAAEAEPEHS 2645
Query: 1260 AKHLRQTIQSLRRQFSGALPLAQQEKFSK 1288
LR+ + + R Q +G L + ++ ++
Sbjct: 2646 FDGLRRKVSAQRLQEAGILSAEELQRLAQ 2674
Score = 53.9 bits (128), Expect = 2e-06
Identities = 233/1241 (18%), Positives = 475/1241 (38%), Gaps = 202/1241 (16%)
Query: 1353 ELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEE--RQMAWD-- 1408
+L + L+ ++L + E ++ L I+++ + EE++ Q + + R +A
Sbjct: 372 KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKV 431
Query: 1409 -QREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRII 1467
QR ++ER LD D + N Q ++ + +L L I+ +
Sbjct: 432 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 491
Query: 1468 LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLI------AE 1521
L+ + + +S R E D + L+ L E + + +
Sbjct: 492 LKAGVAAPATQVAQVTLQSVQRRPELE----DSTLRYLQDLLAWVEENQHRVDGAEWGVD 547
Query: 1522 LGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDL 1581
L E + SH L HQ+I +A++ E+AR ++ ++
Sbjct: 548 LPSVEAQLGSHRGL---HQSIEEFRAKI--------------ERARSDEGQLSPATRGAY 590
Query: 1582 HILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLL 1641
RL+LQ LN K L K + L E E+ D S +
Sbjct: 591 RDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 650
Query: 1642 VKLKKVSQD-LERQREITELKVKEFEN--------------------------------- 1667
+ KK S L R+ E+ E K+KE +N
Sbjct: 651 MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 710
Query: 1668 ---IKLQLQENHE-----DEVKKVKAEVEDL------KYLLDQSQKESQC--LKSELQAQ 1711
I+ L+EN +V++ + +++ L KY D+S ++ L + Q +
Sbjct: 711 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 770
Query: 1712 KEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRA-----------------E 1754
KE + + L +R K+ + LK + R L L A +
Sbjct: 771 KEQLNEYKGH-LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQ 829
Query: 1755 MTAAAEE---RIISATSQKEAHLNVQQIV---DRHTRELKTQVEDLNENLLKLKEALKT- 1807
+ A+ +++S++ + A +V +V ++ +E T++E ++ L+ L L
Sbjct: 830 LVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 889
Query: 1808 --------SKNRENSL----------TDNLNDLNNELQKKQKAYNKILREKEEI------ 1843
S R+ L T + L + Y LR+ ++
Sbjct: 890 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 949
Query: 1844 -----DQENDELKRQIKRLTSGL-QGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDL 1897
++E ++L L QG Q I EL+ +LE V + L
Sbjct: 950 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1009
Query: 1898 KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEK 1957
P+ ++ A+E R E +K QA++EG+ + E +++ L + A
Sbjct: 1010 -PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA----EKVLALPEPSPAAP--- 1061
Query: 1958 LTLQRKLKTTGMTVDQVLGIRALESEK-ELEELKKRNLDLENDILYMRAHQALPRDSVVE 2016
TL+ +L+ T ++QV + A+ EK + L R ++L RAH+ +++
Sbjct: 1062 -TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL--RAHEEQLKEAQAV 1118
Query: 2017 DLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELK 2076
L L+ +L+K ++ +P+ + D + QE+ + +L + E
Sbjct: 1119 PATLPE--LEATKASLKKLRAQAEAQQPTFDALR--DELRGAQEVGE---RLQQRHGERD 1171
Query: 2077 FQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS-GKTIPELEKTIG 2135
++E+ + + +L + + + + ++E ++ R+L + R S G + + +
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1231
Query: 2136 LMKKV-VEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG--HQLSMHY 2192
++ + + Q EQL++ +L IE+ EK++ K ++ +
Sbjct: 1232 QIQAMPLADSQAVREQLRQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQL 1286
Query: 2193 ESKTKGTEKIIAENERLRKELKKETDAAE--KLRIAKNNLEILNEKMTVQLEETGKRLQF 2250
+ E + + ++ + + E+ E LR + L L + + ET +R++
Sbjct: 1287 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1346
Query: 2251 AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKV 2310
E Q + + +L E+E + K+ Q + + K ERE K
Sbjct: 1347 EERLAEQQRAEERE-------------RLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKE 1392
Query: 2311 NKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSG 2370
+ E+ ++ + + + ++ ++ ELQ LR ++ +AE+ Q +A + ++
Sbjct: 1393 LQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQSS------EAEI--QAKARQAEAA 1443
Query: 2371 AESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYN 2430
S + +++E+I+ + QL+ ++ ++ + E++ L+ E E E K
Sbjct: 1444 ERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQALRARAE--------EAEAQKRQ 1491
Query: 2431 YKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEE 2471
+EE ++ + + Q VEL S V A E E++
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1532
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 171 bits (433), Expect = 8e-42
Identities = 351/1737 (20%), Positives = 727/1737 (41%), Gaps = 210/1737 (12%)
Query: 861 YNNLLNALQMDSDEMKKILAENSR-KITVLQVNEKSLIRQYTTLVELERQLRKENEKQKN 919
Y LL +L+ + E + S K LQ+ + + L+++ +E ++
Sbjct: 933 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 992
Query: 920 ELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSL-SELELAN---KQYNELTAK 975
E +AEV E +G K+ AL + + +L SELEL +Q L+A
Sbjct: 993 EQQKAQAEV-EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1051
Query: 976 YRDILQKDNMLVQRTSNLEH-LECENISLKEQ--VESINKELEITKEKLHTIEQAWEQET 1032
Y + L+ +++++ T E L LKE V + ELE TK L + E +
Sbjct: 1052 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ- 1110
Query: 1033 KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE 1092
+ + D + + + V + E ER R E ++ E + L Q +
Sbjct: 1111 ----QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDV 1165
Query: 1093 RNFELETKFAELTKINLDAQKVEQMLRD-ELADSVSKAVSDADRQRILELEKNEMELKVE 1151
R ELE +L A + L+D +A+ AD Q + E + E L E
Sbjct: 1166 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1225
Query: 1152 VSKLRE-ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSD------EKSLIAKLH 1204
+ + E + + R + +NA ++ +QL+ Y+AQ + +K +
Sbjct: 1226 IERHGEKVEECQRFAKQYINA--------IKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1277
Query: 1205 QHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLR 1264
+ + + T +L ++TS+ K + LR +++E+E+ R E R R +
Sbjct: 1278 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERERLAEVE 1334
Query: 1265 QTIQSLRRQFSG-ALPLAQQEKFSKTMIQ-LQNDKLKIMQEMKNSQQEHRNMENKTLEME 1322
++ R+ A AQ E+ +K + Q +Q + ++ + ++QQ+ R+++ + +
Sbjct: 1335 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL--QQ 1392
Query: 1323 LKLKGLEELISTLKDTKGAQKVINWHMKIEE----LRLQELKLNRELVKDKEEIKYLNNI 1378
L+ E+ + + + A++ ++IEE +RLQ R+ + E++ L
Sbjct: 1393 LRQSSEAEIQAKARQAEAAERS---RLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1449
Query: 1379 ISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDI---FDRQQNEILNAAQKF 1435
E E +EE + + ++ Q EV+L ++ R++ L A ++
Sbjct: 1450 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1509
Query: 1436 ----EEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLA 1491
EEA + + Q+++AL + + L+++ S EK + E +L+
Sbjct: 1510 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA--SFAEKTAQLERSLQ-E 1566
Query: 1492 EQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQ 1551
E +++ + E R + A AER + AE + + K++ L++ Q Q Q
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ----Q 1622
Query: 1552 KEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSP 1611
K + ++ E+A E R K E+ + R A+ L K +Q A +Q
Sbjct: 1623 KSLAQAEAEKQKEEAEREARRRGKAEEQAV-----RQRELAEQELEKQRQLAEGTAQQ-- 1675
Query: 1612 TPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFEN---I 1668
RLA AEQ+ L++L+ ++ E+QR++ E ++ +
Sbjct: 1676 ----------RLA------AEQE------LIRLRAETEQGEQQRQLLEEELARLQREAAA 1713
Query: 1669 KLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANS------RAPTTT 1722
Q ++ E E+ KV+AE+E L ++++ES+ + + + EA +
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1773
Query: 1723 MRNLVERLKSQLALKE----KQQKALSRALLELRA---EMTAAAEERIISATSQKEAHLN 1775
+R L E K Q L E +Q+ R L E A E T E I+ ++ +
Sbjct: 1774 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1833
Query: 1776 VQQIVDRHT---RELKTQVE----DLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQK 1828
++++ + R L+ Q D+ E L +L++A + R+ L ++ L++
Sbjct: 1834 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------LRQ 1887
Query: 1829 KQKAYNKILREKEEIDQE---NDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE 1885
+++ +IL K ++ EL+ ++ R+ S + + + L QR++ E
Sbjct: 1888 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1947
Query: 1886 NQLEGKVEEVDLKPM--KEKNAKEELIRWEEGKKWQAKIEG---IRNKLKEKEGEVFTLT 1940
+ + EE K + +E+ A++ EE ++ +AK+E +R + +++ L
Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2007
Query: 1941 K-------QLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGI---------------- 1977
+ Q FA KE+ LQ+ L+ +DQ+ G
Sbjct: 2008 QEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2066
Query: 1978 ----RALESEKELEELKKRNLDLENDI------------LYMRAHQALPRDSVVEDLHLQ 2021
A +S +++EE ++ E L A Q R + E L+
Sbjct: 2067 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2126
Query: 2022 NRYLQEKLHALEKQFSKDTY-SKPSISG--------IESDDHCQR--EQELQK------- 2063
+ + K+F++ T K + +E DH + ++ELQ+
Sbjct: 2127 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2186
Query: 2064 ---ENLKLSSENIELKFQLEQANKDLPRLKNQ-----VRDLKEMCEFLKKEKA---EVQR 2112
+ ++ E ++ Q+E+ +K R++ + +RD FL++E +V
Sbjct: 2187 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2246
Query: 2113 KLGHVRGSGRSGKTIPEL-EKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171
+ + + + + +L E+ + + + EK+ +E Q + + L +E A + Q+ +
Sbjct: 2247 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQK 2304
Query: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLE 2231
+L E + Q++ +T+G ++ + + + E+ E + KLR+A+ +
Sbjct: 2305 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMS-- 2361
Query: 2232 ILNEKMTVQLEETGKRLQF-AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN 2290
+ + EE +R + AE G +L + + + + + + E + ++ + D +
Sbjct: 2362 ----RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2417
Query: 2291 QSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQ 2350
++I +L++ KE ++E K+ + + Q ++ + + E +Q E L
Sbjct: 2418 EAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2476
Query: 2351 LDKEKAEL--IHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
+++EKA+L + Q E K Q E Q++++ + L ++ + + +E +++
Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2536
Query: 2409 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELT-SPVAASE 2464
++EL+ + ++ E+L + +++ + L E+ + + E+T S VAA++
Sbjct: 2537 KQEELQQLEQQRRQQ-EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2592
Score = 145 bits (367), Expect = 4e-34
Identities = 388/1985 (19%), Positives = 766/1985 (38%), Gaps = 335/1985 (16%)
Query: 53 RITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRF 112
R+ L K A+E + E +KA E + + E L + + S
Sbjct: 974 RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT--- 1030
Query: 113 LRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKK 172
LR+E+ +LEQ R L + LEK K ++ L +R + E LR ++LK+
Sbjct: 1031 LRSELELTLGKLEQV-RSLSAIY--LEKLKTIS--LVIRGTQGAEE--VLRAHEEQLKE- 1082
Query: 173 NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKI 232
Q + ++++ K +L R + ++ + ++ ++ DE++ E E++
Sbjct: 1083 ----AQAVPATLPELEATKASLKKLRAQ-----AEAQQPTFDALR--DELRGAQEVGERL 1131
Query: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTD---NVIDQLKKENDHYQLQVQELT 289
+ ++ E +E + E++ R +A++ QTD ++QL ++ +Y+ L
Sbjct: 1132 QQRHGERDVEVE---RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1188
Query: 290 DLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLR---EKLKNAQLDAD 346
L+ + I A + + +++ + Q +L + EK++ Q A
Sbjct: 1189 AWLQDARRRQEQIQAMPLADSQAVR-------EQLRQEQALLEEIERHGEKVEECQRFA- 1240
Query: 347 KSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEK------NTCIIEDLKNELQRNKGAST 400
K + A I++ + Q+ Q+E +K + +I++ + +T
Sbjct: 1241 KQYINA----IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1296
Query: 401 LSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDY-ESGVYGLE 459
L+ Q I TL + +E ER AE A+ RE+ E+ AL++ + E+
Sbjct: 1297 LTSQYIKFISETL----RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1352
Query: 460 DAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTE 519
A E K + +++ +E+ + E D + +++E +L +
Sbjct: 1353 QAEREAKELQQRMQ----------EEVVRREEAAVDAQQQKRSIQE----------ELQQ 1392
Query: 520 FRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQM-----AQERGKRSATSGLTT 574
R S AE Q ++ E+ E RL ++++IR + A ER + A L
Sbjct: 1393 LRQSSE-------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1445
Query: 575 EDLNLTENISQGDRISERKLDLLSLKNMSEAQSKN----EFLSRELIEKERDLERSRTVI 630
E +Q R ++ + + L + E+Q K E SR E E E+ R
Sbjct: 1446 LRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-- 1502
Query: 631 AKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNA-IESK 689
L+ L E Q EE + + QA E + + + + + +R A ++SK
Sbjct: 1503 ------LQALEELRLQAEEAERRLRQAEVERAR-------QVQVALETAQRSAEAELQSK 1549
Query: 690 NAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSL 749
A + QL +E + + R+EA +QQ A+A + E+E
Sbjct: 1550 RAS--------FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1601
Query: 750 --LRQSEGSNVVFKGIDLPD--GIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSL 805
L+ +E + + ++ +A + A + E + E + + + L +
Sbjct: 1602 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1661
Query: 806 EDYNRKFAVIRHQQSLLYKEYL----SEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEY 861
+ R+ A QQ L ++ L +E E + + + ++EE +L+ + K +E
Sbjct: 1662 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1721
Query: 862 NNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNEL 921
L ++ EM+ +LA +R E + R +EK K L
Sbjct: 1722 EAELAKVRA---EMEVLLASKARA---------------------EEESRSTSEKSKQRL 1757
Query: 922 LSMEAEVCEKIGCLQRFKEMA--IFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI 979
EAE RF+E+A ++ AL + L+E + A ++
Sbjct: 1758 ---EAEA-------GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----------- 1796
Query: 980 LQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTI-EQAWEQETKLGNES 1038
+ + +L ++ + + E LK + E KE E E+L + E Q +L ++
Sbjct: 1797 AEAERVLAEKLAAIG----EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852
Query: 1039 SMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1098
+ KA I +++ L +E +R + + E +Q+EE L+
Sbjct: 1853 AQHKA----------DIEERLAQLRKASDSELERQKG---LVEDTLRQRRQVEEEILALK 1899
Query: 1099 TKF----AELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELE----KNEMELKV 1150
F A ++ L+ ++ D L S +A +A RQR L E + E E +V
Sbjct: 1900 ASFEKAAAGKAELELELGRIRSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERV 1958
Query: 1151 EVSKLRE----------ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLI 1200
+ S E + ++ R + ++ A++ E ES R L +A +K L
Sbjct: 1959 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA--QKRLQ 2016
Query: 1201 AKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA 1260
A+ H ++Q E L+ S L ++ + +E E+A R++ A
Sbjct: 2017 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA----RVQAEREA 2072
Query: 1261 KHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLE 1320
R+ ++ R A AQ ++ Q +KL+ K E
Sbjct: 2073 AQSRRQVEEAERLKQSAEEQAQ----ARAQAQAAAEKLR-----------------KEAE 2111
Query: 1321 MELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIIS 1380
E + E + L+ + A + H K E L R+ + ++E+ L +
Sbjct: 2112 QEAARRAQAEQ-AALRQKQAADAEMEKHKKFAEQTL------RQKAQVEQELTTLRLQLE 2164
Query: 1381 EYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG 1440
E + + L+EE+ + E A QR + + E+ + + EE
Sbjct: 2165 ETDHQKNLLDEEL---QRLKAEATEAARQRS-----------QVEEELFSVRVQMEE--- 2207
Query: 1441 SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK 1500
L K+K RI E RA L++K++ R ++ + K
Sbjct: 2208 ----------------LSKLKA--RIEAENRALI------LRDKDNTQRFLQEEA-EKMK 2242
Query: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
+ E RL A+ + +L +++ + K+ + + +Q K E
Sbjct: 2243 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA----- 2297
Query: 1561 RLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF 1620
LL++ +E +E ++ +ED + +L A+ + + + +Q +
Sbjct: 2298 ELLQQQKELAQEQARRLQEDKEQMAQQL---AEETQGFQRTLEAERQRQLEMSAEAERLK 2354
Query: 1621 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHED-- 1678
+R+AEM + A ++ + +++ + L R T+ KV + +++Q Q++ D
Sbjct: 2355 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2414
Query: 1679 EVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738
+++ AE+E K L Q K Q E+Q ++ T ++ K L +E
Sbjct: 2415 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2474
Query: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENL 1798
R + + +A++ ++ + A +E QQ +++ + L +E+
Sbjct: 2475 -------RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2527
Query: 1799 LKLKEALKTS-----------KNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEN 1847
+ +E ++ + +E L + L +LQ ++ + L EE+
Sbjct: 2528 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2587
Query: 1848 DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKE 1907
+ + L G + + L+RKV Q G + +L+ + + +
Sbjct: 2588 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTV 2647
Query: 1908 ELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLT----LQRK 1963
+ + A+ E +R+ L+ + +++ L KA EKL+ LQR+
Sbjct: 2648 DEL---------ARREDVRHYLQGR-----------SSIAGLLLKATNEKLSVYAALQRQ 2687
Query: 1964 LKTTG 1968
L + G
Sbjct: 2688 LLSPG 2692
Score = 137 bits (346), Expect = 1e-31
Identities = 374/2011 (18%), Positives = 809/2011 (40%), Gaps = 281/2011 (13%)
Query: 641 VEENKQLEEG----MKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696
V+ +LE+ ++++L ++E Q D G E + +PS+E + + G+
Sbjct: 479 VQRRPELEDSTLRYLQDLLAWVEENQHRVD--GAEWGVDLPSVEAQLGS-----HRGLHQ 531
Query: 697 ASLHLKAQVDQLTGRNEELRQELRESRKEAIN-----YSQQLAKANLKIDHLE------- 744
+ +A++++ +L R + ++ + Y++ L + ++ LE
Sbjct: 532 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVA 591
Query: 745 ---KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNL 801
KE L + E V F D + ++ E L++ELE KEKK+K L
Sbjct: 592 AATKELMWLNEKEEEEVGFDWSDRNTNMT--------AKKESYSALMRELELKEKKIKEL 643
Query: 802 EDS-----LEDYNRKFAVIRHQQSL------------LYKEYLSEKETWKTESKTIKEEK 844
+++ ED+ + V Q +L + +L E + ++E +
Sbjct: 644 QNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAE 703
Query: 845 RKLEDQVQQDAIKVKEYN-------NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
+L Q Q+A++ ++Y+ L L D+ + K+ L E ++ L K+++
Sbjct: 704 GQL--QKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 760
Query: 898 ----RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953
R + L + ++ E+ + + C+ +G Q + + + V
Sbjct: 761 QLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQP-SHWKVLSSSGSEAAV 819
Query: 954 DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENI----SLKEQVES 1009
+ L + N++ E + L+ + + + H++ +++ SL+ V+
Sbjct: 820 PSVCFL--VPPPNQEAQEAVTR----LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 873
Query: 1010 INK---------ELEITKEKLHTIE---QAWEQETKLGNESSMDKAKKSITNSDIVSISK 1057
I + E ++ LH++E QA+ ++++ + + + + S S
Sbjct: 874 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQ--DAGGFGPEDRLMAEREYGSCSH 931
Query: 1058 KITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLD------- 1110
L Q CQ+ L+ Q+E ET+ ++ LD
Sbjct: 932 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE----ACETRTVHRLRLPLDKEPAREC 987
Query: 1111 AQKV-EQMLRDELADSVSKAVS--DADRQRILELE---------KNEMELKV-EVSKLRE 1157
AQ++ EQ + + K V+ A+ +++L L ++E+EL + ++ ++R
Sbjct: 988 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1047
Query: 1158 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA 1217
+S I +++ ++ + E LR + + + +L SL+ A A
Sbjct: 1048 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1107
Query: 1218 LGK---LESITSKLQKMEAYNLRLEQKLDEKEQALYYAR--------------LEGRNRA 1260
+ +++ +L+ + RL+Q+ E++ + R + R
Sbjct: 1108 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1167
Query: 1261 KHLRQTIQSLRRQFSGALPLA---QQEKFSKTMIQLQ--NDKLKIMQEMKNSQQEHRNME 1315
+ L Q + LR A PL Q + + IQ D + ++++ Q +E
Sbjct: 1168 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1227
Query: 1316 NKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELK---------LNRELV 1366
++E + ++ I+ +KD + +++ + ++E + K + +E V
Sbjct: 1228 RHGEKVEECQRFAKQYINAIKDYE--LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1285
Query: 1367 KDKEEIKYLNNIISEYERTISSL------EEEIVQQNKFHEERQMAWDQREVDLERQLDI 1420
+ L + S+Y + IS EE + +Q + E ++A + E LE+Q +
Sbjct: 1286 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQL 1343
Query: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEK 1480
+ A ++ +E + + + + E A+ ++ I E + +S E +
Sbjct: 1344 AEAHAQAKAQAEREAKELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1400
Query: 1481 LKEKESALRLAEQNILSRDKVINELRLRLPAT------AEREKLIAELGRKEMEPKSHHT 1534
++ K AE++ L ++ I +RL+L AT AE E +E E +
Sbjct: 1401 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1460
Query: 1535 LKIAHQTIANMQARLNQKE----EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 1590
+ A + +Q +K E+ + + E ARE+QR + E L L
Sbjct: 1461 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---------LRL 1511
Query: 1591 QADSSLNKFKQTAWDLMKQSPTPVPTNKHFI------RLAEMEQTVAEQDDSLSSLLVKL 1644
QA+ + + +Q + +Q + T + + A + A+ + SL V +
Sbjct: 1512 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1571
Query: 1645 KKVSQDLER--QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDL--KYLLDQSQKE 1700
++ ++ ER Q++ + +E +L+ + +E +++ + E++ + L Q++ E
Sbjct: 1572 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631
Query: 1701 SQCLKSELQAQKEANSRAPTTTMRNLVER-LKSQLALKE---KQQKALSRALLELRAEMT 1756
Q ++E +A++ + R L E+ L+ Q L E +Q+ A + L+ LRAE
Sbjct: 1632 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1691
Query: 1757 AAAEERII----SATSQKEAHLNVQ--QIVDRHTRELKTQVEDLNENLLKLKEALKT--- 1807
++R + A Q+EA Q Q ++ +++ ++E L + + +E ++
Sbjct: 1692 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1751
Query: 1808 -SKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPL 1866
SK R + +L E + + + R+++ +++ + + +R+ +
Sbjct: 1752 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA------- 1804
Query: 1867 TDNKQSLIEELQRKVKKLENQL-EGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIE-- 1923
K + I E R + E L E + E L+ + E A + E+ + +A IE
Sbjct: 1805 --EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1862
Query: 1924 ------GIRNKLKEKEGEVFTLTKQ-------LNTLKDLFAKADKEKLTLQRKLKTTGMT 1970
++L+ ++G V +Q + LK F KA K L+ +L
Sbjct: 1863 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1922
Query: 1971 VDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLH 2030
+ L + + ELE ++R L E + A + + + E+ + R + L
Sbjct: 1923 AEDTL---RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALE 1977
Query: 2031 ALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQ-ANKDLPRL 2089
+E+ +K E+ +R ++ L+L+ E + + Q E+ A+ +
Sbjct: 1978 EVERLKAKVE---------EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2028
Query: 2090 KNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENE 2149
K Q E+ + L++E++ + + G + R+ + E +VQ E E
Sbjct: 2029 KEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------------ARVQAERE 2071
Query: 2150 QLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERL 2209
+ + +E++ +E + +A+ + L + + + + + + +
Sbjct: 2072 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2131
Query: 2210 RKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETG--KRLQFAESRGPQLEGADSKSWK 2267
E++K AE+ K +E + +QLEET K L E + + E ++ +
Sbjct: 2132 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2191
Query: 2268 SIVVTRMYETK-----LKELETDIAKKNQSITDLKQLVKEATER--EQKVNKYNEDLEQQ 2320
S V ++ + L +L+ I +N+++ L+ K+ T+R +++ K + E+
Sbjct: 2192 SQVEEELFSVRVQMEELSKLKARIEAENRALI-LRD--KDNTQRFLQEEAEKMKQVAEEA 2248
Query: 2321 IKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQ 2380
++ E A Q + +L R ++ KEK + + EA + ++ AE +
Sbjct: 2249 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKEL 2306
Query: 2381 LKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFE---EIEDLKYNYKEEVKK 2437
+E+ + L+ + Q L EE + ++ LE E E E LK E +
Sbjct: 2307 AQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2363
Query: 2438 NILLEE---KVKKLSEQLGVELTSPVAASEE 2465
EE + +K +E++G +L A++E
Sbjct: 2364 QARAEEDAQRFRKQAEEIGEKLHRTELATQE 2394
Score = 130 bits (327), Expect = 2e-29
Identities = 247/1349 (18%), Positives = 554/1349 (41%), Gaps = 139/1349 (10%)
Query: 39 ELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL 98
E EKQ + ++ + +A+E++ ++E EE A Q K + + +L
Sbjct: 1334 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1393
Query: 99 EMA----------QQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQL 148
+ Q A R + EI + QLE +R+ E EL+ + E+
Sbjct: 1394 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1453
Query: 149 ALRNEEAENENSKLRR----ENKRLKKKNEQLCQDI-------IDYQKQIDSQKETLLSR 197
+ +A+ E +LRR E++R ++ +L + + Q+ + + +E L
Sbjct: 1454 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1513
Query: 198 RGEDSDYRSQLSKKNYELIQYLDEIQTLTEAN-EKIEVQNQEMRKNLEESVQE----MEK 252
+ R ++ ++ L+ Q EA + E LE S+QE + +
Sbjct: 1514 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1573
Query: 253 MTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDL-LKSKNEEDDPIMVAVNAKVE 311
+ +E R + + ++ ++E + +QL+ E L L+++ + A+ +
Sbjct: 1574 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1633
Query: 312 EWKLILSSK-----DDEIIEYQQMLHNLREKLKN------AQLDADKSNVMALQQGIQER 360
+ + ++ +++ + +++ EK + Q A + ++ L+ ++
Sbjct: 1634 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1693
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQR---------------NKGASTLSQQT 405
+ Q ++L E++ + +E T ++L+ EL + + + + S+++
Sbjct: 1694 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1753
Query: 406 HMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEI 465
++++ +E +EA R LAE R++ +A ++ + E + A+ E
Sbjct: 1754 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1813
Query: 466 KNCKNQIKIRDREIEILTKEINKL--ELKISDFLDENEALRERVGLEPKTMIDLTEFRNS 523
K + +I +E E + + +L + E +A + + +E + L + R +
Sbjct: 1814 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKA 1869
Query: 524 KHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSG---LTTEDLNLT 580
+ ++ + + L++ +EEE L LK + A + + G ED +
Sbjct: 1870 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1929
Query: 581 ENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKEL 640
+ ++ + +R+L + EA+ + ++ + E + R R + +LK
Sbjct: 1930 KEQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAK 1985
Query: 641 VEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLH 700
VEE ++L E ++ ++ +++Q E + E +A + E +L
Sbjct: 1986 VEEARRLRERAEQ--ESARQLQ-----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2038
Query: 701 LKAQV-DQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVV 759
+ V DQL G E R+ E+ + + ++ A++ +++ E+ L+QS
Sbjct: 2039 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER----LKQSAEEQAQ 2094
Query: 760 FKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQ 819
+ A ++A + + E + E + K D+ + ++KFA +Q
Sbjct: 2095 AR------AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2148
Query: 820 SLLYKEYLS----EKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEM 875
++ L+ + E + + EE ++L+ + + A + + L ++++ +E+
Sbjct: 2149 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2208
Query: 876 KKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEA----EVCEK 931
K+ A + L + +K +++ E E+ + E + + + EA ++ E+
Sbjct: 2209 SKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2267
Query: 932 IGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTS 991
QR + K +Q V + + +E EL +Q EL + LQ+D + +
Sbjct: 2268 DLAQQRALAEKMLK-EKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQL 2325
Query: 992 NLEHLECENISLKEQVESINKELEITKEKLHTIE----QAWEQETKLGNESSMDKAKKSI 1047
E + E+ + E + KL E QA +E ++ + +
Sbjct: 2326 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2385
Query: 1048 TNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFEL--ETKFAELT 1105
+++ + +K+T+++ E+ +RQ+++H E LR ++ ++E +L E K +L
Sbjct: 2386 HRTELAT-QEKVTLVQTLEI-QRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLK 2440
Query: 1106 KINLDAQKVEQMLRDELA---DSVSKAVSDADRQRILELEKNEME--LKVEVSKLREISD 1160
+ + EQ+L++ A +S+ S R+R +E EK ++E + EV+K +++ +
Sbjct: 2441 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2500
Query: 1161 IARRQVEILNAQQQSRDKEVESLR----------------MQLLDYQAQSDEKSLIAKLH 1204
+RQ + + ++Q +E R +Q L+ Q + E+ L +
Sbjct: 2501 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2560
Query: 1205 QHNVSLQLSE---ATALGKLESITSKLQKMEAYNLRLEQKLDEKEQAL--YYARLEGRNR 1259
+ LQL E AL E +T A + + L AL A E +
Sbjct: 2561 RLREQLQLLEEQHRAALAHSEEVT-------ASQVAATKTLPNGRDALDGPAAEAEPEHS 2613
Query: 1260 AKHLRQTIQSLRRQFSGALPLAQQEKFSK 1288
LR+ + + R Q +G L + ++ ++
Sbjct: 2614 FDGLRRKVSAQRLQEAGILSAEELQRLAQ 2642
Score = 53.9 bits (128), Expect = 2e-06
Identities = 233/1241 (18%), Positives = 475/1241 (38%), Gaps = 202/1241 (16%)
Query: 1353 ELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEE--RQMAWD-- 1408
+L + L+ ++L + E ++ L I+++ + EE++ Q + + R +A
Sbjct: 340 KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKV 399
Query: 1409 -QREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRII 1467
QR ++ER LD D + N Q ++ + +L L I+ +
Sbjct: 400 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 459
Query: 1468 LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLI------AE 1521
L+ + + +S R E D + L+ L E + + +
Sbjct: 460 LKAGVAAPATQVAQVTLQSVQRRPELE----DSTLRYLQDLLAWVEENQHRVDGAEWGVD 515
Query: 1522 LGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDL 1581
L E + SH L HQ+I +A++ E+AR ++ ++
Sbjct: 516 LPSVEAQLGSHRGL---HQSIEEFRAKI--------------ERARSDEGQLSPATRGAY 558
Query: 1582 HILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLL 1641
RL+LQ LN K L K + L E E+ D S +
Sbjct: 559 RDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 618
Query: 1642 VKLKKVSQD-LERQREITELKVKEFEN--------------------------------- 1667
+ KK S L R+ E+ E K+KE +N
Sbjct: 619 MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 678
Query: 1668 ---IKLQLQENHE-----DEVKKVKAEVEDL------KYLLDQSQKESQC--LKSELQAQ 1711
I+ L+EN +V++ + +++ L KY D+S ++ L + Q +
Sbjct: 679 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 738
Query: 1712 KEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRA-----------------E 1754
KE + + L +R K+ + LK + R L L A +
Sbjct: 739 KEQLNEYKGH-LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQ 797
Query: 1755 MTAAAEE---RIISATSQKEAHLNVQQIV---DRHTRELKTQVEDLNENLLKLKEALKT- 1807
+ A+ +++S++ + A +V +V ++ +E T++E ++ L+ L L
Sbjct: 798 LVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 857
Query: 1808 --------SKNRENSL----------TDNLNDLNNELQKKQKAYNKILREKEEI------ 1843
S R+ L T + L + Y LR+ ++
Sbjct: 858 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 917
Query: 1844 -----DQENDELKRQIKRLTSGL-QGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDL 1897
++E ++L L QG Q I EL+ +LE V + L
Sbjct: 918 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 977
Query: 1898 KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEK 1957
P+ ++ A+E R E +K QA++EG+ + E +++ L + A
Sbjct: 978 -PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA----EKVLALPEPSPAAP--- 1029
Query: 1958 LTLQRKLKTTGMTVDQVLGIRALESEK-ELEELKKRNLDLENDILYMRAHQALPRDSVVE 2016
TL+ +L+ T ++QV + A+ EK + L R ++L RAH+ +++
Sbjct: 1030 -TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL--RAHEEQLKEAQAV 1086
Query: 2017 DLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELK 2076
L L+ +L+K ++ +P+ + D + QE+ + +L + E
Sbjct: 1087 PATLPE--LEATKASLKKLRAQAEAQQPTFDALR--DELRGAQEVGE---RLQQRHGERD 1139
Query: 2077 FQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS-GKTIPELEKTIG 2135
++E+ + + +L + + + + ++E ++ R+L + R S G + + +
Sbjct: 1140 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1199
Query: 2136 LMKKV-VEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG--HQLSMHY 2192
++ + + Q EQL++ +L IE+ EK++ K ++ +
Sbjct: 1200 QIQAMPLADSQAVREQLRQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQL 1254
Query: 2193 ESKTKGTEKIIAENERLRKELKKETDAAE--KLRIAKNNLEILNEKMTVQLEETGKRLQF 2250
+ E + + ++ + + E+ E LR + L L + + ET +R++
Sbjct: 1255 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1314
Query: 2251 AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKV 2310
E Q + + +L E+E + K+ Q + + K ERE K
Sbjct: 1315 EERLAEQQRAEERE-------------RLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKE 1360
Query: 2311 NKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSG 2370
+ E+ ++ + + + ++ ++ ELQ LR ++ +AE+ Q +A + ++
Sbjct: 1361 LQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQSS------EAEI--QAKARQAEAA 1411
Query: 2371 AESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYN 2430
S + +++E+I+ + QL+ ++ ++ + E++ L+ E E E K
Sbjct: 1412 ERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQALRARAE--------EAEAQKRQ 1459
Query: 2431 YKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEE 2471
+EE ++ + + Q VEL S V A E E++
Sbjct: 1460 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1500
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 171 bits (433), Expect = 8e-42
Identities = 351/1737 (20%), Positives = 727/1737 (41%), Gaps = 210/1737 (12%)
Query: 861 YNNLLNALQMDSDEMKKILAENSR-KITVLQVNEKSLIRQYTTLVELERQLRKENEKQKN 919
Y LL +L+ + E + S K LQ+ + + L+++ +E ++
Sbjct: 1102 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1161
Query: 920 ELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSL-SELELAN---KQYNELTAK 975
E +AEV E +G K+ AL + + +L SELEL +Q L+A
Sbjct: 1162 EQQKAQAEV-EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1220
Query: 976 YRDILQKDNMLVQRTSNLEH-LECENISLKEQ--VESINKELEITKEKLHTIEQAWEQET 1032
Y + L+ +++++ T E L LKE V + ELE TK L + E +
Sbjct: 1221 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ- 1279
Query: 1033 KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE 1092
+ + D + + + V + E ER R E ++ E + L Q +
Sbjct: 1280 ----QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDV 1334
Query: 1093 RNFELETKFAELTKINLDAQKVEQMLRD-ELADSVSKAVSDADRQRILELEKNEMELKVE 1151
R ELE +L A + L+D +A+ AD Q + E + E L E
Sbjct: 1335 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1394
Query: 1152 VSKLRE-ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSD------EKSLIAKLH 1204
+ + E + + R + +NA ++ +QL+ Y+AQ + +K +
Sbjct: 1395 IERHGEKVEECQRFAKQYINA--------IKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1446
Query: 1205 QHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLR 1264
+ + + T +L ++TS+ K + LR +++E+E+ R E R R +
Sbjct: 1447 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERERLAEVE 1503
Query: 1265 QTIQSLRRQFSG-ALPLAQQEKFSKTMIQ-LQNDKLKIMQEMKNSQQEHRNMENKTLEME 1322
++ R+ A AQ E+ +K + Q +Q + ++ + ++QQ+ R+++ + +
Sbjct: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL--QQ 1561
Query: 1323 LKLKGLEELISTLKDTKGAQKVINWHMKIEE----LRLQELKLNRELVKDKEEIKYLNNI 1378
L+ E+ + + + A++ ++IEE +RLQ R+ + E++ L
Sbjct: 1562 LRQSSEAEIQAKARQAEAAERS---RLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1618
Query: 1379 ISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDI---FDRQQNEILNAAQKF 1435
E E +EE + + ++ Q EV+L ++ R++ L A ++
Sbjct: 1619 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1678
Query: 1436 ----EEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLA 1491
EEA + + Q+++AL + + L+++ S EK + E +L+
Sbjct: 1679 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA--SFAEKTAQLERSLQ-E 1735
Query: 1492 EQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQ 1551
E +++ + E R + A AER + AE + + K++ L++ Q Q Q
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ----Q 1791
Query: 1552 KEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSP 1611
K + ++ E+A E R K E+ + R A+ L K +Q A +Q
Sbjct: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAV-----RQRELAEQELEKQRQLAEGTAQQ-- 1844
Query: 1612 TPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFEN---I 1668
RLA AEQ+ L++L+ ++ E+QR++ E ++ +
Sbjct: 1845 ----------RLA------AEQE------LIRLRAETEQGEQQRQLLEEELARLQREAAA 1882
Query: 1669 KLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANS------RAPTTT 1722
Q ++ E E+ KV+AE+E L ++++ES+ + + + EA +
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1942
Query: 1723 MRNLVERLKSQLALKE----KQQKALSRALLELRA---EMTAAAEERIISATSQKEAHLN 1775
+R L E K Q L E +Q+ R L E A E T E I+ ++ +
Sbjct: 1943 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 2002
Query: 1776 VQQIVDRHT---RELKTQVE----DLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQK 1828
++++ + R L+ Q D+ E L +L++A + R+ L ++ L++
Sbjct: 2003 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------LRQ 2056
Query: 1829 KQKAYNKILREKEEIDQE---NDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE 1885
+++ +IL K ++ EL+ ++ R+ S + + + L QR++ E
Sbjct: 2057 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2116
Query: 1886 NQLEGKVEEVDLKPM--KEKNAKEELIRWEEGKKWQAKIEG---IRNKLKEKEGEVFTLT 1940
+ + EE K + +E+ A++ EE ++ +AK+E +R + +++ L
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2176
Query: 1941 K-------QLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGI---------------- 1977
+ Q FA KE+ LQ+ L+ +DQ+ G
Sbjct: 2177 QEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2235
Query: 1978 ----RALESEKELEELKKRNLDLENDI------------LYMRAHQALPRDSVVEDLHLQ 2021
A +S +++EE ++ E L A Q R + E L+
Sbjct: 2236 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2295
Query: 2022 NRYLQEKLHALEKQFSKDTY-SKPSISG--------IESDDHCQR--EQELQK------- 2063
+ + K+F++ T K + +E DH + ++ELQ+
Sbjct: 2296 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2355
Query: 2064 ---ENLKLSSENIELKFQLEQANKDLPRLKNQ-----VRDLKEMCEFLKKEKA---EVQR 2112
+ ++ E ++ Q+E+ +K R++ + +RD FL++E +V
Sbjct: 2356 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2415
Query: 2113 KLGHVRGSGRSGKTIPEL-EKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171
+ + + + + +L E+ + + + EK+ +E Q + + L +E A + Q+ +
Sbjct: 2416 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQK 2473
Query: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLE 2231
+L E + Q++ +T+G ++ + + + E+ E + KLR+A+ +
Sbjct: 2474 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMS-- 2530
Query: 2232 ILNEKMTVQLEETGKRLQF-AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN 2290
+ + EE +R + AE G +L + + + + + + E + ++ + D +
Sbjct: 2531 ----RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2586
Query: 2291 QSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQ 2350
++I +L++ KE ++E K+ + + Q ++ + + E +Q E L
Sbjct: 2587 EAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2645
Query: 2351 LDKEKAEL--IHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
+++EKA+L + Q E K Q E Q++++ + L ++ + + +E +++
Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2705
Query: 2409 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELT-SPVAASE 2464
++EL+ + ++ E+L + +++ + L E+ + + E+T S VAA++
Sbjct: 2706 KQEELQQLEQQRRQQ-EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2761
Score = 145 bits (367), Expect = 4e-34
Identities = 388/1985 (19%), Positives = 766/1985 (38%), Gaps = 335/1985 (16%)
Query: 53 RITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRF 112
R+ L K A+E + E +KA E + + E L + + S
Sbjct: 1143 RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT--- 1199
Query: 113 LRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKK 172
LR+E+ +LEQ R L + LEK K ++ L +R + E LR ++LK+
Sbjct: 1200 LRSELELTLGKLEQV-RSLSAIY--LEKLKTIS--LVIRGTQGAEE--VLRAHEEQLKE- 1251
Query: 173 NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKI 232
Q + ++++ K +L R + ++ + ++ ++ DE++ E E++
Sbjct: 1252 ----AQAVPATLPELEATKASLKKLRAQ-----AEAQQPTFDALR--DELRGAQEVGERL 1300
Query: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTD---NVIDQLKKENDHYQLQVQELT 289
+ ++ E +E + E++ R +A++ QTD ++QL ++ +Y+ L
Sbjct: 1301 QQRHGERDVEVE---RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1357
Query: 290 DLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLR---EKLKNAQLDAD 346
L+ + I A + + +++ + Q +L + EK++ Q A
Sbjct: 1358 AWLQDARRRQEQIQAMPLADSQAVR-------EQLRQEQALLEEIERHGEKVEECQRFA- 1409
Query: 347 KSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEK------NTCIIEDLKNELQRNKGAST 400
K + A I++ + Q+ Q+E +K + +I++ + +T
Sbjct: 1410 KQYINA----IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1465
Query: 401 LSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDY-ESGVYGLE 459
L+ Q I TL + +E ER AE A+ RE+ E+ AL++ + E+
Sbjct: 1466 LTSQYIKFISETL----RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1521
Query: 460 DAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTE 519
A E K + +++ +E+ + E D + +++E +L +
Sbjct: 1522 QAEREAKELQQRMQ----------EEVVRREEAAVDAQQQKRSIQE----------ELQQ 1561
Query: 520 FRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQM-----AQERGKRSATSGLTT 574
R S AE Q ++ E+ E RL ++++IR + A ER + A L
Sbjct: 1562 LRQSSE-------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614
Query: 575 EDLNLTENISQGDRISERKLDLLSLKNMSEAQSKN----EFLSRELIEKERDLERSRTVI 630
E +Q R ++ + + L + E+Q K E SR E E E+ R
Sbjct: 1615 LRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-- 1671
Query: 631 AKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNA-IESK 689
L+ L E Q EE + + QA E + + + + + +R A ++SK
Sbjct: 1672 ------LQALEELRLQAEEAERRLRQAEVERAR-------QVQVALETAQRSAEAELQSK 1718
Query: 690 NAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSL 749
A + QL +E + + R+EA +QQ A+A + E+E
Sbjct: 1719 RAS--------FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770
Query: 750 --LRQSEGSNVVFKGIDLPD--GIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSL 805
L+ +E + + ++ +A + A + E + E + + + L +
Sbjct: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830
Query: 806 EDYNRKFAVIRHQQSLLYKEYL----SEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEY 861
+ R+ A QQ L ++ L +E E + + + ++EE +L+ + K +E
Sbjct: 1831 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1890
Query: 862 NNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNEL 921
L ++ EM+ +LA +R E + R +EK K L
Sbjct: 1891 EAELAKVRA---EMEVLLASKARA---------------------EEESRSTSEKSKQRL 1926
Query: 922 LSMEAEVCEKIGCLQRFKEMA--IFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI 979
EAE RF+E+A ++ AL + L+E + A ++
Sbjct: 1927 ---EAEA-------GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----------- 1965
Query: 980 LQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTI-EQAWEQETKLGNES 1038
+ + +L ++ + + E LK + E KE E E+L + E Q +L ++
Sbjct: 1966 AEAERVLAEKLAAIG----EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021
Query: 1039 SMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1098
+ KA I +++ L +E +R + + E +Q+EE L+
Sbjct: 2022 AQHKA----------DIEERLAQLRKASDSELERQKG---LVEDTLRQRRQVEEEILALK 2068
Query: 1099 TKF----AELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELE----KNEMELKV 1150
F A ++ L+ ++ D L S +A +A RQR L E + E E +V
Sbjct: 2069 ASFEKAAAGKAELELELGRIRSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERV 2127
Query: 1151 EVSKLRE----------ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLI 1200
+ S E + ++ R + ++ A++ E ES R L +A +K L
Sbjct: 2128 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA--QKRLQ 2185
Query: 1201 AKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA 1260
A+ H ++Q E L+ S L ++ + +E E+A R++ A
Sbjct: 2186 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA----RVQAEREA 2241
Query: 1261 KHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLE 1320
R+ ++ R A AQ ++ Q +KL+ K E
Sbjct: 2242 AQSRRQVEEAERLKQSAEEQAQ----ARAQAQAAAEKLR-----------------KEAE 2280
Query: 1321 MELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIIS 1380
E + E + L+ + A + H K E L R+ + ++E+ L +
Sbjct: 2281 QEAARRAQAEQ-AALRQKQAADAEMEKHKKFAEQTL------RQKAQVEQELTTLRLQLE 2333
Query: 1381 EYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG 1440
E + + L+EE+ + E A QR + + E+ + + EE
Sbjct: 2334 ETDHQKNLLDEEL---QRLKAEATEAARQRS-----------QVEEELFSVRVQMEE--- 2376
Query: 1441 SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK 1500
L K+K RI E RA L++K++ R ++ + K
Sbjct: 2377 ----------------LSKLKA--RIEAENRALI------LRDKDNTQRFLQEEA-EKMK 2411
Query: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
+ E RL A+ + +L +++ + K+ + + +Q K E
Sbjct: 2412 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA----- 2466
Query: 1561 RLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF 1620
LL++ +E +E ++ +ED + +L A+ + + + +Q +
Sbjct: 2467 ELLQQQKELAQEQARRLQEDKEQMAQQL---AEETQGFQRTLEAERQRQLEMSAEAERLK 2523
Query: 1621 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHED-- 1678
+R+AEM + A ++ + +++ + L R T+ KV + +++Q Q++ D
Sbjct: 2524 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2583
Query: 1679 EVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738
+++ AE+E K L Q K Q E+Q ++ T ++ K L +E
Sbjct: 2584 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2643
Query: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENL 1798
R + + +A++ ++ + A +E QQ +++ + L +E+
Sbjct: 2644 -------RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2696
Query: 1799 LKLKEALKTS-----------KNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEN 1847
+ +E ++ + +E L + L +LQ ++ + L EE+
Sbjct: 2697 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2756
Query: 1848 DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKE 1907
+ + L G + + L+RKV Q G + +L+ + + +
Sbjct: 2757 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTV 2816
Query: 1908 ELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLT----LQRK 1963
+ + A+ E +R+ L+ + +++ L KA EKL+ LQR+
Sbjct: 2817 DEL---------ARREDVRHYLQGR-----------SSIAGLLLKATNEKLSVYAALQRQ 2856
Query: 1964 LKTTG 1968
L + G
Sbjct: 2857 LLSPG 2861
Score = 137 bits (346), Expect = 1e-31
Identities = 374/2011 (18%), Positives = 809/2011 (40%), Gaps = 281/2011 (13%)
Query: 641 VEENKQLEEG----MKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696
V+ +LE+ ++++L ++E Q D G E + +PS+E + + G+
Sbjct: 648 VQRRPELEDSTLRYLQDLLAWVEENQHRVD--GAEWGVDLPSVEAQLGS-----HRGLHQ 700
Query: 697 ASLHLKAQVDQLTGRNEELRQELRESRKEAIN-----YSQQLAKANLKIDHLE------- 744
+ +A++++ +L R + ++ + Y++ L + ++ LE
Sbjct: 701 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVA 760
Query: 745 ---KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNL 801
KE L + E V F D + ++ E L++ELE KEKK+K L
Sbjct: 761 AATKELMWLNEKEEEEVGFDWSDRNTNMT--------AKKESYSALMRELELKEKKIKEL 812
Query: 802 EDS-----LEDYNRKFAVIRHQQSL------------LYKEYLSEKETWKTESKTIKEEK 844
+++ ED+ + V Q +L + +L E + ++E +
Sbjct: 813 QNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAE 872
Query: 845 RKLEDQVQQDAIKVKEYN-------NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
+L Q Q+A++ ++Y+ L L D+ + K+ L E ++ L K+++
Sbjct: 873 GQL--QKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 929
Query: 898 ----RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953
R + L + ++ E+ + + C+ +G Q + + + V
Sbjct: 930 QLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQP-SHWKVLSSSGSEAAV 988
Query: 954 DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENI----SLKEQVES 1009
+ L + N++ E + L+ + + + H++ +++ SL+ V+
Sbjct: 989 PSVCFL--VPPPNQEAQEAVTR----LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 1042
Query: 1010 INK---------ELEITKEKLHTIE---QAWEQETKLGNESSMDKAKKSITNSDIVSISK 1057
I + E ++ LH++E QA+ ++++ + + + + S S
Sbjct: 1043 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQ--DAGGFGPEDRLMAEREYGSCSH 1100
Query: 1058 KITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLD------- 1110
L Q CQ+ L+ Q+E ET+ ++ LD
Sbjct: 1101 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE----ACETRTVHRLRLPLDKEPAREC 1156
Query: 1111 AQKV-EQMLRDELADSVSKAVS--DADRQRILELE---------KNEMELKV-EVSKLRE 1157
AQ++ EQ + + K V+ A+ +++L L ++E+EL + ++ ++R
Sbjct: 1157 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1216
Query: 1158 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA 1217
+S I +++ ++ + E LR + + + +L SL+ A A
Sbjct: 1217 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1276
Query: 1218 LGK---LESITSKLQKMEAYNLRLEQKLDEKEQALYYAR--------------LEGRNRA 1260
+ +++ +L+ + RL+Q+ E++ + R + R
Sbjct: 1277 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1336
Query: 1261 KHLRQTIQSLRRQFSGALPLA---QQEKFSKTMIQLQ--NDKLKIMQEMKNSQQEHRNME 1315
+ L Q + LR A PL Q + + IQ D + ++++ Q +E
Sbjct: 1337 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1396
Query: 1316 NKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELK---------LNRELV 1366
++E + ++ I+ +KD + +++ + ++E + K + +E V
Sbjct: 1397 RHGEKVEECQRFAKQYINAIKDYE--LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1454
Query: 1367 KDKEEIKYLNNIISEYERTISSL------EEEIVQQNKFHEERQMAWDQREVDLERQLDI 1420
+ L + S+Y + IS EE + +Q + E ++A + E LE+Q +
Sbjct: 1455 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQL 1512
Query: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEK 1480
+ A ++ +E + + + + E A+ ++ I E + +S E +
Sbjct: 1513 AEAHAQAKAQAEREAKELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1569
Query: 1481 LKEKESALRLAEQNILSRDKVINELRLRLPAT------AEREKLIAELGRKEMEPKSHHT 1534
++ K AE++ L ++ I +RL+L AT AE E +E E +
Sbjct: 1570 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1629
Query: 1535 LKIAHQTIANMQARLNQKE----EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 1590
+ A + +Q +K E+ + + E ARE+QR + E L L
Sbjct: 1630 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---------LRL 1680
Query: 1591 QADSSLNKFKQTAWDLMKQSPTPVPTNKHFI------RLAEMEQTVAEQDDSLSSLLVKL 1644
QA+ + + +Q + +Q + T + + A + A+ + SL V +
Sbjct: 1681 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740
Query: 1645 KKVSQDLER--QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDL--KYLLDQSQKE 1700
++ ++ ER Q++ + +E +L+ + +E +++ + E++ + L Q++ E
Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800
Query: 1701 SQCLKSELQAQKEANSRAPTTTMRNLVER-LKSQLALKE---KQQKALSRALLELRAEMT 1756
Q ++E +A++ + R L E+ L+ Q L E +Q+ A + L+ LRAE
Sbjct: 1801 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860
Query: 1757 AAAEERII----SATSQKEAHLNVQ--QIVDRHTRELKTQVEDLNENLLKLKEALKT--- 1807
++R + A Q+EA Q Q ++ +++ ++E L + + +E ++
Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920
Query: 1808 -SKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPL 1866
SK R + +L E + + + R+++ +++ + + +R+ +
Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA------- 1973
Query: 1867 TDNKQSLIEELQRKVKKLENQL-EGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIE-- 1923
K + I E R + E L E + E L+ + E A + E+ + +A IE
Sbjct: 1974 --EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031
Query: 1924 ------GIRNKLKEKEGEVFTLTKQ-------LNTLKDLFAKADKEKLTLQRKLKTTGMT 1970
++L+ ++G V +Q + LK F KA K L+ +L
Sbjct: 2032 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 2091
Query: 1971 VDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLH 2030
+ L + + ELE ++R L E + A + + + E+ + R + L
Sbjct: 2092 AEDTL---RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALE 2146
Query: 2031 ALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQ-ANKDLPRL 2089
+E+ +K E+ +R ++ L+L+ E + + Q E+ A+ +
Sbjct: 2147 EVERLKAKVE---------EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2197
Query: 2090 KNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENE 2149
K Q E+ + L++E++ + + G + R+ + E +VQ E E
Sbjct: 2198 KEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------------ARVQAERE 2240
Query: 2150 QLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERL 2209
+ + +E++ +E + +A+ + L + + + + + + +
Sbjct: 2241 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2300
Query: 2210 RKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETG--KRLQFAESRGPQLEGADSKSWK 2267
E++K AE+ K +E + +QLEET K L E + + E ++ +
Sbjct: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360
Query: 2268 SIVVTRMYETK-----LKELETDIAKKNQSITDLKQLVKEATER--EQKVNKYNEDLEQQ 2320
S V ++ + L +L+ I +N+++ L+ K+ T+R +++ K + E+
Sbjct: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALI-LRD--KDNTQRFLQEEAEKMKQVAEEA 2417
Query: 2321 IKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQ 2380
++ E A Q + +L R ++ KEK + + EA + ++ AE +
Sbjct: 2418 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKEL 2475
Query: 2381 LKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFE---EIEDLKYNYKEEVKK 2437
+E+ + L+ + Q L EE + ++ LE E E E LK E +
Sbjct: 2476 AQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2532
Query: 2438 NILLEE---KVKKLSEQLGVELTSPVAASEE 2465
EE + +K +E++G +L A++E
Sbjct: 2533 QARAEEDAQRFRKQAEEIGEKLHRTELATQE 2563
Score = 130 bits (327), Expect = 2e-29
Identities = 247/1349 (18%), Positives = 554/1349 (41%), Gaps = 139/1349 (10%)
Query: 39 ELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL 98
E EKQ + ++ + +A+E++ ++E EE A Q K + + +L
Sbjct: 1503 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562
Query: 99 EMA----------QQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQL 148
+ Q A R + EI + QLE +R+ E EL+ + E+
Sbjct: 1563 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1622
Query: 149 ALRNEEAENENSKLRR----ENKRLKKKNEQLCQDI-------IDYQKQIDSQKETLLSR 197
+ +A+ E +LRR E++R ++ +L + + Q+ + + +E L
Sbjct: 1623 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1682
Query: 198 RGEDSDYRSQLSKKNYELIQYLDEIQTLTEAN-EKIEVQNQEMRKNLEESVQE----MEK 252
+ R ++ ++ L+ Q EA + E LE S+QE + +
Sbjct: 1683 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1742
Query: 253 MTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDL-LKSKNEEDDPIMVAVNAKVE 311
+ +E R + + ++ ++E + +QL+ E L L+++ + A+ +
Sbjct: 1743 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1802
Query: 312 EWKLILSSK-----DDEIIEYQQMLHNLREKLKN------AQLDADKSNVMALQQGIQER 360
+ + ++ +++ + +++ EK + Q A + ++ L+ ++
Sbjct: 1803 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1862
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQR---------------NKGASTLSQQT 405
+ Q ++L E++ + +E T ++L+ EL + + + + S+++
Sbjct: 1863 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1922
Query: 406 HMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEI 465
++++ +E +EA R LAE R++ +A ++ + E + A+ E
Sbjct: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1982
Query: 466 KNCKNQIKIRDREIEILTKEINKL--ELKISDFLDENEALRERVGLEPKTMIDLTEFRNS 523
K + +I +E E + + +L + E +A + + +E + L + R +
Sbjct: 1983 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKA 2038
Query: 524 KHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSG---LTTEDLNLT 580
+ ++ + + L++ +EEE L LK + A + + G ED +
Sbjct: 2039 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098
Query: 581 ENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKEL 640
+ ++ + +R+L + EA+ + ++ + E + R R + +LK
Sbjct: 2099 KEQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAK 2154
Query: 641 VEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLH 700
VEE ++L E ++ ++ +++Q E + E +A + E +L
Sbjct: 2155 VEEARRLRERAEQ--ESARQLQ-----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2207
Query: 701 LKAQV-DQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVV 759
+ V DQL G E R+ E+ + + ++ A++ +++ E+ L+QS
Sbjct: 2208 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER----LKQSAEEQAQ 2263
Query: 760 FKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQ 819
+ A ++A + + E + E + K D+ + ++KFA +Q
Sbjct: 2264 AR------AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2317
Query: 820 SLLYKEYLS----EKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEM 875
++ L+ + E + + EE ++L+ + + A + + L ++++ +E+
Sbjct: 2318 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2377
Query: 876 KKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEA----EVCEK 931
K+ A + L + +K +++ E E+ + E + + + EA ++ E+
Sbjct: 2378 SKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2436
Query: 932 IGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTS 991
QR + K +Q V + + +E EL +Q EL + LQ+D + +
Sbjct: 2437 DLAQQRALAEKMLK-EKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQL 2494
Query: 992 NLEHLECENISLKEQVESINKELEITKEKLHTIE----QAWEQETKLGNESSMDKAKKSI 1047
E + E+ + E + KL E QA +E ++ + +
Sbjct: 2495 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2554
Query: 1048 TNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFEL--ETKFAELT 1105
+++ + +K+T+++ E+ +RQ+++H E LR ++ ++E +L E K +L
Sbjct: 2555 HRTELAT-QEKVTLVQTLEI-QRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLK 2609
Query: 1106 KINLDAQKVEQMLRDELA---DSVSKAVSDADRQRILELEKNEME--LKVEVSKLREISD 1160
+ + EQ+L++ A +S+ S R+R +E EK ++E + EV+K +++ +
Sbjct: 2610 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669
Query: 1161 IARRQVEILNAQQQSRDKEVESLR----------------MQLLDYQAQSDEKSLIAKLH 1204
+RQ + + ++Q +E R +Q L+ Q + E+ L +
Sbjct: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2729
Query: 1205 QHNVSLQLSE---ATALGKLESITSKLQKMEAYNLRLEQKLDEKEQAL--YYARLEGRNR 1259
+ LQL E AL E +T A + + L AL A E +
Sbjct: 2730 RLREQLQLLEEQHRAALAHSEEVT-------ASQVAATKTLPNGRDALDGPAAEAEPEHS 2782
Query: 1260 AKHLRQTIQSLRRQFSGALPLAQQEKFSK 1288
LR+ + + R Q +G L + ++ ++
Sbjct: 2783 FDGLRRKVSAQRLQEAGILSAEELQRLAQ 2811
Score = 53.9 bits (128), Expect = 2e-06
Identities = 233/1241 (18%), Positives = 475/1241 (38%), Gaps = 202/1241 (16%)
Query: 1353 ELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEE--RQMAWD-- 1408
+L + L+ ++L + E ++ L I+++ + EE++ Q + + R +A
Sbjct: 509 KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKV 568
Query: 1409 -QREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRII 1467
QR ++ER LD D + N Q ++ + +L L I+ +
Sbjct: 569 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 628
Query: 1468 LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLI------AE 1521
L+ + + +S R E D + L+ L E + + +
Sbjct: 629 LKAGVAAPATQVAQVTLQSVQRRPELE----DSTLRYLQDLLAWVEENQHRVDGAEWGVD 684
Query: 1522 LGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDL 1581
L E + SH L HQ+I +A++ E+AR ++ ++
Sbjct: 685 LPSVEAQLGSHRGL---HQSIEEFRAKI--------------ERARSDEGQLSPATRGAY 727
Query: 1582 HILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLL 1641
RL+LQ LN K L K + L E E+ D S +
Sbjct: 728 RDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 787
Query: 1642 VKLKKVSQD-LERQREITELKVKEFEN--------------------------------- 1667
+ KK S L R+ E+ E K+KE +N
Sbjct: 788 MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 847
Query: 1668 ---IKLQLQENHE-----DEVKKVKAEVEDL------KYLLDQSQKESQC--LKSELQAQ 1711
I+ L+EN +V++ + +++ L KY D+S ++ L + Q +
Sbjct: 848 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 907
Query: 1712 KEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRA-----------------E 1754
KE + + L +R K+ + LK + R L L A +
Sbjct: 908 KEQLNEYKGH-LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQ 966
Query: 1755 MTAAAEE---RIISATSQKEAHLNVQQIV---DRHTRELKTQVEDLNENLLKLKEALKT- 1807
+ A+ +++S++ + A +V +V ++ +E T++E ++ L+ L L
Sbjct: 967 LVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 1026
Query: 1808 --------SKNRENSL----------TDNLNDLNNELQKKQKAYNKILREKEEI------ 1843
S R+ L T + L + Y LR+ ++
Sbjct: 1027 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 1086
Query: 1844 -----DQENDELKRQIKRLTSGL-QGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDL 1897
++E ++L L QG Q I EL+ +LE V + L
Sbjct: 1087 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1146
Query: 1898 KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEK 1957
P+ ++ A+E R E +K QA++EG+ + E +++ L + A
Sbjct: 1147 -PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA----EKVLALPEPSPAAP--- 1198
Query: 1958 LTLQRKLKTTGMTVDQVLGIRALESEK-ELEELKKRNLDLENDILYMRAHQALPRDSVVE 2016
TL+ +L+ T ++QV + A+ EK + L R ++L RAH+ +++
Sbjct: 1199 -TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL--RAHEEQLKEAQAV 1255
Query: 2017 DLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELK 2076
L L+ +L+K ++ +P+ + D + QE+ + +L + E
Sbjct: 1256 PATLPE--LEATKASLKKLRAQAEAQQPTFDALR--DELRGAQEVGE---RLQQRHGERD 1308
Query: 2077 FQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS-GKTIPELEKTIG 2135
++E+ + + +L + + + + ++E ++ R+L + R S G + + +
Sbjct: 1309 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1368
Query: 2136 LMKKV-VEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG--HQLSMHY 2192
++ + + Q EQL++ +L IE+ EK++ K ++ +
Sbjct: 1369 QIQAMPLADSQAVREQLRQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQL 1423
Query: 2193 ESKTKGTEKIIAENERLRKELKKETDAAE--KLRIAKNNLEILNEKMTVQLEETGKRLQF 2250
+ E + + ++ + + E+ E LR + L L + + ET +R++
Sbjct: 1424 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1483
Query: 2251 AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKV 2310
E Q + + +L E+E + K+ Q + + K ERE K
Sbjct: 1484 EERLAEQQRAEERE-------------RLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKE 1529
Query: 2311 NKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSG 2370
+ E+ ++ + + + ++ ++ ELQ LR ++ +AE+ Q +A + ++
Sbjct: 1530 LQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQSS------EAEI--QAKARQAEAA 1580
Query: 2371 AESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYN 2430
S + +++E+I+ + QL+ ++ ++ + E++ L+ E E E K
Sbjct: 1581 ERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQALRARAE--------EAEAQKRQ 1628
Query: 2431 YKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEE 2471
+EE ++ + + Q VEL S V A E E++
Sbjct: 1629 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1669
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 171 bits (433), Expect = 8e-42
Identities = 351/1737 (20%), Positives = 727/1737 (41%), Gaps = 210/1737 (12%)
Query: 861 YNNLLNALQMDSDEMKKILAENSR-KITVLQVNEKSLIRQYTTLVELERQLRKENEKQKN 919
Y LL +L+ + E + S K LQ+ + + L+++ +E ++
Sbjct: 943 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1002
Query: 920 ELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSL-SELELAN---KQYNELTAK 975
E +AEV E +G K+ AL + + +L SELEL +Q L+A
Sbjct: 1003 EQQKAQAEV-EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1061
Query: 976 YRDILQKDNMLVQRTSNLEH-LECENISLKEQ--VESINKELEITKEKLHTIEQAWEQET 1032
Y + L+ +++++ T E L LKE V + ELE TK L + E +
Sbjct: 1062 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ- 1120
Query: 1033 KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE 1092
+ + D + + + V + E ER R E ++ E + L Q +
Sbjct: 1121 ----QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDV 1175
Query: 1093 RNFELETKFAELTKINLDAQKVEQMLRD-ELADSVSKAVSDADRQRILELEKNEMELKVE 1151
R ELE +L A + L+D +A+ AD Q + E + E L E
Sbjct: 1176 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1235
Query: 1152 VSKLRE-ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSD------EKSLIAKLH 1204
+ + E + + R + +NA ++ +QL+ Y+AQ + +K +
Sbjct: 1236 IERHGEKVEECQRFAKQYINA--------IKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1287
Query: 1205 QHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLR 1264
+ + + T +L ++TS+ K + LR +++E+E+ R E R R +
Sbjct: 1288 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERERLAEVE 1344
Query: 1265 QTIQSLRRQFSG-ALPLAQQEKFSKTMIQ-LQNDKLKIMQEMKNSQQEHRNMENKTLEME 1322
++ R+ A AQ E+ +K + Q +Q + ++ + ++QQ+ R+++ + +
Sbjct: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL--QQ 1402
Query: 1323 LKLKGLEELISTLKDTKGAQKVINWHMKIEE----LRLQELKLNRELVKDKEEIKYLNNI 1378
L+ E+ + + + A++ ++IEE +RLQ R+ + E++ L
Sbjct: 1403 LRQSSEAEIQAKARQAEAAERS---RLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1459
Query: 1379 ISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDI---FDRQQNEILNAAQKF 1435
E E +EE + + ++ Q EV+L ++ R++ L A ++
Sbjct: 1460 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1519
Query: 1436 ----EEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLA 1491
EEA + + Q+++AL + + L+++ S EK + E +L+
Sbjct: 1520 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA--SFAEKTAQLERSLQ-E 1576
Query: 1492 EQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQ 1551
E +++ + E R + A AER + AE + + K++ L++ Q Q Q
Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ----Q 1632
Query: 1552 KEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSP 1611
K + ++ E+A E R K E+ + R A+ L K +Q A +Q
Sbjct: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAV-----RQRELAEQELEKQRQLAEGTAQQ-- 1685
Query: 1612 TPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFEN---I 1668
RLA AEQ+ L++L+ ++ E+QR++ E ++ +
Sbjct: 1686 ----------RLA------AEQE------LIRLRAETEQGEQQRQLLEEELARLQREAAA 1723
Query: 1669 KLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANS------RAPTTT 1722
Q ++ E E+ KV+AE+E L ++++ES+ + + + EA +
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1783
Query: 1723 MRNLVERLKSQLALKE----KQQKALSRALLELRA---EMTAAAEERIISATSQKEAHLN 1775
+R L E K Q L E +Q+ R L E A E T E I+ ++ +
Sbjct: 1784 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1843
Query: 1776 VQQIVDRHT---RELKTQVE----DLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQK 1828
++++ + R L+ Q D+ E L +L++A + R+ L ++ L++
Sbjct: 1844 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------LRQ 1897
Query: 1829 KQKAYNKILREKEEIDQE---NDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE 1885
+++ +IL K ++ EL+ ++ R+ S + + + L QR++ E
Sbjct: 1898 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1957
Query: 1886 NQLEGKVEEVDLKPM--KEKNAKEELIRWEEGKKWQAKIEG---IRNKLKEKEGEVFTLT 1940
+ + EE K + +E+ A++ EE ++ +AK+E +R + +++ L
Sbjct: 1958 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2017
Query: 1941 K-------QLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGI---------------- 1977
+ Q FA KE+ LQ+ L+ +DQ+ G
Sbjct: 2018 QEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2076
Query: 1978 ----RALESEKELEELKKRNLDLENDI------------LYMRAHQALPRDSVVEDLHLQ 2021
A +S +++EE ++ E L A Q R + E L+
Sbjct: 2077 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2136
Query: 2022 NRYLQEKLHALEKQFSKDTY-SKPSISG--------IESDDHCQR--EQELQK------- 2063
+ + K+F++ T K + +E DH + ++ELQ+
Sbjct: 2137 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2196
Query: 2064 ---ENLKLSSENIELKFQLEQANKDLPRLKNQ-----VRDLKEMCEFLKKEKA---EVQR 2112
+ ++ E ++ Q+E+ +K R++ + +RD FL++E +V
Sbjct: 2197 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2256
Query: 2113 KLGHVRGSGRSGKTIPEL-EKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171
+ + + + + +L E+ + + + EK+ +E Q + + L +E A + Q+ +
Sbjct: 2257 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQK 2314
Query: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLE 2231
+L E + Q++ +T+G ++ + + + E+ E + KLR+A+ +
Sbjct: 2315 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMS-- 2371
Query: 2232 ILNEKMTVQLEETGKRLQF-AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN 2290
+ + EE +R + AE G +L + + + + + + E + ++ + D +
Sbjct: 2372 ----RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2427
Query: 2291 QSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQ 2350
++I +L++ KE ++E K+ + + Q ++ + + E +Q E L
Sbjct: 2428 EAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2486
Query: 2351 LDKEKAEL--IHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
+++EKA+L + Q E K Q E Q++++ + L ++ + + +E +++
Sbjct: 2487 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2546
Query: 2409 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELT-SPVAASE 2464
++EL+ + ++ E+L + +++ + L E+ + + E+T S VAA++
Sbjct: 2547 KQEELQQLEQQRRQQ-EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2602
Score = 145 bits (367), Expect = 4e-34
Identities = 388/1985 (19%), Positives = 766/1985 (38%), Gaps = 335/1985 (16%)
Query: 53 RITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRF 112
R+ L K A+E + E +KA E + + E L + + S
Sbjct: 984 RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT--- 1040
Query: 113 LRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKK 172
LR+E+ +LEQ R L + LEK K ++ L +R + E LR ++LK+
Sbjct: 1041 LRSELELTLGKLEQV-RSLSAIY--LEKLKTIS--LVIRGTQGAEE--VLRAHEEQLKE- 1092
Query: 173 NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKI 232
Q + ++++ K +L R + ++ + ++ ++ DE++ E E++
Sbjct: 1093 ----AQAVPATLPELEATKASLKKLRAQ-----AEAQQPTFDALR--DELRGAQEVGERL 1141
Query: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTD---NVIDQLKKENDHYQLQVQELT 289
+ ++ E +E + E++ R +A++ QTD ++QL ++ +Y+ L
Sbjct: 1142 QQRHGERDVEVE---RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1198
Query: 290 DLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLR---EKLKNAQLDAD 346
L+ + I A + + +++ + Q +L + EK++ Q A
Sbjct: 1199 AWLQDARRRQEQIQAMPLADSQAVR-------EQLRQEQALLEEIERHGEKVEECQRFA- 1250
Query: 347 KSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEK------NTCIIEDLKNELQRNKGAST 400
K + A I++ + Q+ Q+E +K + +I++ + +T
Sbjct: 1251 KQYINA----IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1306
Query: 401 LSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDY-ESGVYGLE 459
L+ Q I TL + +E ER AE A+ RE+ E+ AL++ + E+
Sbjct: 1307 LTSQYIKFISETL----RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1362
Query: 460 DAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTE 519
A E K + +++ +E+ + E D + +++E +L +
Sbjct: 1363 QAEREAKELQQRMQ----------EEVVRREEAAVDAQQQKRSIQE----------ELQQ 1402
Query: 520 FRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQM-----AQERGKRSATSGLTT 574
R S AE Q ++ E+ E RL ++++IR + A ER + A L
Sbjct: 1403 LRQSSE-------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455
Query: 575 EDLNLTENISQGDRISERKLDLLSLKNMSEAQSKN----EFLSRELIEKERDLERSRTVI 630
E +Q R ++ + + L + E+Q K E SR E E E+ R
Sbjct: 1456 LRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-- 1512
Query: 631 AKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNA-IESK 689
L+ L E Q EE + + QA E + + + + + +R A ++SK
Sbjct: 1513 ------LQALEELRLQAEEAERRLRQAEVERAR-------QVQVALETAQRSAEAELQSK 1559
Query: 690 NAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSL 749
A + QL +E + + R+EA +QQ A+A + E+E
Sbjct: 1560 RAS--------FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611
Query: 750 --LRQSEGSNVVFKGIDLPD--GIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSL 805
L+ +E + + ++ +A + A + E + E + + + L +
Sbjct: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671
Query: 806 EDYNRKFAVIRHQQSLLYKEYL----SEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEY 861
+ R+ A QQ L ++ L +E E + + + ++EE +L+ + K +E
Sbjct: 1672 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1731
Query: 862 NNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNEL 921
L ++ EM+ +LA +R E + R +EK K L
Sbjct: 1732 EAELAKVRA---EMEVLLASKARA---------------------EEESRSTSEKSKQRL 1767
Query: 922 LSMEAEVCEKIGCLQRFKEMA--IFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI 979
EAE RF+E+A ++ AL + L+E + A ++
Sbjct: 1768 ---EAEA-------GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----------- 1806
Query: 980 LQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTI-EQAWEQETKLGNES 1038
+ + +L ++ + + E LK + E KE E E+L + E Q +L ++
Sbjct: 1807 AEAERVLAEKLAAIG----EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1862
Query: 1039 SMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1098
+ KA I +++ L +E +R + + E +Q+EE L+
Sbjct: 1863 AQHKA----------DIEERLAQLRKASDSELERQKG---LVEDTLRQRRQVEEEILALK 1909
Query: 1099 TKF----AELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELE----KNEMELKV 1150
F A ++ L+ ++ D L S +A +A RQR L E + E E +V
Sbjct: 1910 ASFEKAAAGKAELELELGRIRSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERV 1968
Query: 1151 EVSKLRE----------ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLI 1200
+ S E + ++ R + ++ A++ E ES R L +A +K L
Sbjct: 1969 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA--QKRLQ 2026
Query: 1201 AKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA 1260
A+ H ++Q E L+ S L ++ + +E E+A R++ A
Sbjct: 2027 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA----RVQAEREA 2082
Query: 1261 KHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLE 1320
R+ ++ R A AQ ++ Q +KL+ K E
Sbjct: 2083 AQSRRQVEEAERLKQSAEEQAQ----ARAQAQAAAEKLR-----------------KEAE 2121
Query: 1321 MELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIIS 1380
E + E + L+ + A + H K E L R+ + ++E+ L +
Sbjct: 2122 QEAARRAQAEQ-AALRQKQAADAEMEKHKKFAEQTL------RQKAQVEQELTTLRLQLE 2174
Query: 1381 EYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG 1440
E + + L+EE+ + E A QR + + E+ + + EE
Sbjct: 2175 ETDHQKNLLDEEL---QRLKAEATEAARQRS-----------QVEEELFSVRVQMEE--- 2217
Query: 1441 SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK 1500
L K+K RI E RA L++K++ R ++ + K
Sbjct: 2218 ----------------LSKLKA--RIEAENRALI------LRDKDNTQRFLQEEA-EKMK 2252
Query: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
+ E RL A+ + +L +++ + K+ + + +Q K E
Sbjct: 2253 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA----- 2307
Query: 1561 RLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF 1620
LL++ +E +E ++ +ED + +L A+ + + + +Q +
Sbjct: 2308 ELLQQQKELAQEQARRLQEDKEQMAQQL---AEETQGFQRTLEAERQRQLEMSAEAERLK 2364
Query: 1621 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHED-- 1678
+R+AEM + A ++ + +++ + L R T+ KV + +++Q Q++ D
Sbjct: 2365 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2424
Query: 1679 EVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738
+++ AE+E K L Q K Q E+Q ++ T ++ K L +E
Sbjct: 2425 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2484
Query: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENL 1798
R + + +A++ ++ + A +E QQ +++ + L +E+
Sbjct: 2485 -------RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2537
Query: 1799 LKLKEALKTS-----------KNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEN 1847
+ +E ++ + +E L + L +LQ ++ + L EE+
Sbjct: 2538 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2597
Query: 1848 DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKE 1907
+ + L G + + L+RKV Q G + +L+ + + +
Sbjct: 2598 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTV 2657
Query: 1908 ELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLT----LQRK 1963
+ + A+ E +R+ L+ + +++ L KA EKL+ LQR+
Sbjct: 2658 DEL---------ARREDVRHYLQGR-----------SSIAGLLLKATNEKLSVYAALQRQ 2697
Query: 1964 LKTTG 1968
L + G
Sbjct: 2698 LLSPG 2702
Score = 137 bits (346), Expect = 1e-31
Identities = 374/2011 (18%), Positives = 809/2011 (40%), Gaps = 281/2011 (13%)
Query: 641 VEENKQLEEG----MKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696
V+ +LE+ ++++L ++E Q D G E + +PS+E + + G+
Sbjct: 489 VQRRPELEDSTLRYLQDLLAWVEENQHRVD--GAEWGVDLPSVEAQLGS-----HRGLHQ 541
Query: 697 ASLHLKAQVDQLTGRNEELRQELRESRKEAIN-----YSQQLAKANLKIDHLE------- 744
+ +A++++ +L R + ++ + Y++ L + ++ LE
Sbjct: 542 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVA 601
Query: 745 ---KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNL 801
KE L + E V F D + ++ E L++ELE KEKK+K L
Sbjct: 602 AATKELMWLNEKEEEEVGFDWSDRNTNMT--------AKKESYSALMRELELKEKKIKEL 653
Query: 802 EDS-----LEDYNRKFAVIRHQQSL------------LYKEYLSEKETWKTESKTIKEEK 844
+++ ED+ + V Q +L + +L E + ++E +
Sbjct: 654 QNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAE 713
Query: 845 RKLEDQVQQDAIKVKEYN-------NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
+L Q Q+A++ ++Y+ L L D+ + K+ L E ++ L K+++
Sbjct: 714 GQL--QKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 770
Query: 898 ----RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953
R + L + ++ E+ + + C+ +G Q + + + V
Sbjct: 771 QLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQP-SHWKVLSSSGSEAAV 829
Query: 954 DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENI----SLKEQVES 1009
+ L + N++ E + L+ + + + H++ +++ SL+ V+
Sbjct: 830 PSVCFL--VPPPNQEAQEAVTR----LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 883
Query: 1010 INK---------ELEITKEKLHTIE---QAWEQETKLGNESSMDKAKKSITNSDIVSISK 1057
I + E ++ LH++E QA+ ++++ + + + + S S
Sbjct: 884 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQ--DAGGFGPEDRLMAEREYGSCSH 941
Query: 1058 KITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLD------- 1110
L Q CQ+ L+ Q+E ET+ ++ LD
Sbjct: 942 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE----ACETRTVHRLRLPLDKEPAREC 997
Query: 1111 AQKV-EQMLRDELADSVSKAVS--DADRQRILELE---------KNEMELKV-EVSKLRE 1157
AQ++ EQ + + K V+ A+ +++L L ++E+EL + ++ ++R
Sbjct: 998 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1057
Query: 1158 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA 1217
+S I +++ ++ + E LR + + + +L SL+ A A
Sbjct: 1058 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1117
Query: 1218 LGK---LESITSKLQKMEAYNLRLEQKLDEKEQALYYAR--------------LEGRNRA 1260
+ +++ +L+ + RL+Q+ E++ + R + R
Sbjct: 1118 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1177
Query: 1261 KHLRQTIQSLRRQFSGALPLA---QQEKFSKTMIQLQ--NDKLKIMQEMKNSQQEHRNME 1315
+ L Q + LR A PL Q + + IQ D + ++++ Q +E
Sbjct: 1178 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1237
Query: 1316 NKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELK---------LNRELV 1366
++E + ++ I+ +KD + +++ + ++E + K + +E V
Sbjct: 1238 RHGEKVEECQRFAKQYINAIKDYE--LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1295
Query: 1367 KDKEEIKYLNNIISEYERTISSL------EEEIVQQNKFHEERQMAWDQREVDLERQLDI 1420
+ L + S+Y + IS EE + +Q + E ++A + E LE+Q +
Sbjct: 1296 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQL 1353
Query: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEK 1480
+ A ++ +E + + + + E A+ ++ I E + +S E +
Sbjct: 1354 AEAHAQAKAQAEREAKELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1410
Query: 1481 LKEKESALRLAEQNILSRDKVINELRLRLPAT------AEREKLIAELGRKEMEPKSHHT 1534
++ K AE++ L ++ I +RL+L AT AE E +E E +
Sbjct: 1411 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1470
Query: 1535 LKIAHQTIANMQARLNQKE----EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 1590
+ A + +Q +K E+ + + E ARE+QR + E L L
Sbjct: 1471 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---------LRL 1521
Query: 1591 QADSSLNKFKQTAWDLMKQSPTPVPTNKHFI------RLAEMEQTVAEQDDSLSSLLVKL 1644
QA+ + + +Q + +Q + T + + A + A+ + SL V +
Sbjct: 1522 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1581
Query: 1645 KKVSQDLER--QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDL--KYLLDQSQKE 1700
++ ++ ER Q++ + +E +L+ + +E +++ + E++ + L Q++ E
Sbjct: 1582 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1641
Query: 1701 SQCLKSELQAQKEANSRAPTTTMRNLVER-LKSQLALKE---KQQKALSRALLELRAEMT 1756
Q ++E +A++ + R L E+ L+ Q L E +Q+ A + L+ LRAE
Sbjct: 1642 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1701
Query: 1757 AAAEERII----SATSQKEAHLNVQ--QIVDRHTRELKTQVEDLNENLLKLKEALKT--- 1807
++R + A Q+EA Q Q ++ +++ ++E L + + +E ++
Sbjct: 1702 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1761
Query: 1808 -SKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPL 1866
SK R + +L E + + + R+++ +++ + + +R+ +
Sbjct: 1762 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA------- 1814
Query: 1867 TDNKQSLIEELQRKVKKLENQL-EGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIE-- 1923
K + I E R + E L E + E L+ + E A + E+ + +A IE
Sbjct: 1815 --EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872
Query: 1924 ------GIRNKLKEKEGEVFTLTKQ-------LNTLKDLFAKADKEKLTLQRKLKTTGMT 1970
++L+ ++G V +Q + LK F KA K L+ +L
Sbjct: 1873 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1932
Query: 1971 VDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLH 2030
+ L + + ELE ++R L E + A + + + E+ + R + L
Sbjct: 1933 AEDTL---RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALE 1987
Query: 2031 ALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQ-ANKDLPRL 2089
+E+ +K E+ +R ++ L+L+ E + + Q E+ A+ +
Sbjct: 1988 EVERLKAKVE---------EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2038
Query: 2090 KNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENE 2149
K Q E+ + L++E++ + + G + R+ + E +VQ E E
Sbjct: 2039 KEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------------ARVQAERE 2081
Query: 2150 QLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERL 2209
+ + +E++ +E + +A+ + L + + + + + + +
Sbjct: 2082 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2141
Query: 2210 RKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETG--KRLQFAESRGPQLEGADSKSWK 2267
E++K AE+ K +E + +QLEET K L E + + E ++ +
Sbjct: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201
Query: 2268 SIVVTRMYETK-----LKELETDIAKKNQSITDLKQLVKEATER--EQKVNKYNEDLEQQ 2320
S V ++ + L +L+ I +N+++ L+ K+ T+R +++ K + E+
Sbjct: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALI-LRD--KDNTQRFLQEEAEKMKQVAEEA 2258
Query: 2321 IKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQ 2380
++ E A Q + +L R ++ KEK + + EA + ++ AE +
Sbjct: 2259 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKEL 2316
Query: 2381 LKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFE---EIEDLKYNYKEEVKK 2437
+E+ + L+ + Q L EE + ++ LE E E E LK E +
Sbjct: 2317 AQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2373
Query: 2438 NILLEE---KVKKLSEQLGVELTSPVAASEE 2465
EE + +K +E++G +L A++E
Sbjct: 2374 QARAEEDAQRFRKQAEEIGEKLHRTELATQE 2404
Score = 130 bits (327), Expect = 2e-29
Identities = 247/1349 (18%), Positives = 554/1349 (41%), Gaps = 139/1349 (10%)
Query: 39 ELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL 98
E EKQ + ++ + +A+E++ ++E EE A Q K + + +L
Sbjct: 1344 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
Query: 99 EMA----------QQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQL 148
+ Q A R + EI + QLE +R+ E EL+ + E+
Sbjct: 1404 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1463
Query: 149 ALRNEEAENENSKLRR----ENKRLKKKNEQLCQDI-------IDYQKQIDSQKETLLSR 197
+ +A+ E +LRR E++R ++ +L + + Q+ + + +E L
Sbjct: 1464 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1523
Query: 198 RGEDSDYRSQLSKKNYELIQYLDEIQTLTEAN-EKIEVQNQEMRKNLEESVQE----MEK 252
+ R ++ ++ L+ Q EA + E LE S+QE + +
Sbjct: 1524 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1583
Query: 253 MTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDL-LKSKNEEDDPIMVAVNAKVE 311
+ +E R + + ++ ++E + +QL+ E L L+++ + A+ +
Sbjct: 1584 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1643
Query: 312 EWKLILSSK-----DDEIIEYQQMLHNLREKLKN------AQLDADKSNVMALQQGIQER 360
+ + ++ +++ + +++ EK + Q A + ++ L+ ++
Sbjct: 1644 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1703
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQR---------------NKGASTLSQQT 405
+ Q ++L E++ + +E T ++L+ EL + + + + S+++
Sbjct: 1704 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1763
Query: 406 HMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEI 465
++++ +E +EA R LAE R++ +A ++ + E + A+ E
Sbjct: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1823
Query: 466 KNCKNQIKIRDREIEILTKEINKL--ELKISDFLDENEALRERVGLEPKTMIDLTEFRNS 523
K + +I +E E + + +L + E +A + + +E + L + R +
Sbjct: 1824 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKA 1879
Query: 524 KHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSG---LTTEDLNLT 580
+ ++ + + L++ +EEE L LK + A + + G ED +
Sbjct: 1880 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1939
Query: 581 ENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKEL 640
+ ++ + +R+L + EA+ + ++ + E + R R + +LK
Sbjct: 1940 KEQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAK 1995
Query: 641 VEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLH 700
VEE ++L E ++ ++ +++Q E + E +A + E +L
Sbjct: 1996 VEEARRLRERAEQ--ESARQLQ-----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2048
Query: 701 LKAQV-DQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVV 759
+ V DQL G E R+ E+ + + ++ A++ +++ E+ L+QS
Sbjct: 2049 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER----LKQSAEEQAQ 2104
Query: 760 FKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQ 819
+ A ++A + + E + E + K D+ + ++KFA +Q
Sbjct: 2105 AR------AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2158
Query: 820 SLLYKEYLS----EKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEM 875
++ L+ + E + + EE ++L+ + + A + + L ++++ +E+
Sbjct: 2159 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2218
Query: 876 KKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEA----EVCEK 931
K+ A + L + +K +++ E E+ + E + + + EA ++ E+
Sbjct: 2219 SKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2277
Query: 932 IGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTS 991
QR + K +Q V + + +E EL +Q EL + LQ+D + +
Sbjct: 2278 DLAQQRALAEKMLK-EKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQL 2335
Query: 992 NLEHLECENISLKEQVESINKELEITKEKLHTIE----QAWEQETKLGNESSMDKAKKSI 1047
E + E+ + E + KL E QA +E ++ + +
Sbjct: 2336 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2395
Query: 1048 TNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFEL--ETKFAELT 1105
+++ + +K+T+++ E+ +RQ+++H E LR ++ ++E +L E K +L
Sbjct: 2396 HRTELAT-QEKVTLVQTLEI-QRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLK 2450
Query: 1106 KINLDAQKVEQMLRDELA---DSVSKAVSDADRQRILELEKNEME--LKVEVSKLREISD 1160
+ + EQ+L++ A +S+ S R+R +E EK ++E + EV+K +++ +
Sbjct: 2451 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2510
Query: 1161 IARRQVEILNAQQQSRDKEVESLR----------------MQLLDYQAQSDEKSLIAKLH 1204
+RQ + + ++Q +E R +Q L+ Q + E+ L +
Sbjct: 2511 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2570
Query: 1205 QHNVSLQLSE---ATALGKLESITSKLQKMEAYNLRLEQKLDEKEQAL--YYARLEGRNR 1259
+ LQL E AL E +T A + + L AL A E +
Sbjct: 2571 RLREQLQLLEEQHRAALAHSEEVT-------ASQVAATKTLPNGRDALDGPAAEAEPEHS 2623
Query: 1260 AKHLRQTIQSLRRQFSGALPLAQQEKFSK 1288
LR+ + + R Q +G L + ++ ++
Sbjct: 2624 FDGLRRKVSAQRLQEAGILSAEELQRLAQ 2652
Score = 53.9 bits (128), Expect = 2e-06
Identities = 233/1241 (18%), Positives = 475/1241 (38%), Gaps = 202/1241 (16%)
Query: 1353 ELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEE--RQMAWD-- 1408
+L + L+ ++L + E ++ L I+++ + EE++ Q + + R +A
Sbjct: 350 KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKV 409
Query: 1409 -QREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRII 1467
QR ++ER LD D + N Q ++ + +L L I+ +
Sbjct: 410 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 469
Query: 1468 LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLI------AE 1521
L+ + + +S R E D + L+ L E + + +
Sbjct: 470 LKAGVAAPATQVAQVTLQSVQRRPELE----DSTLRYLQDLLAWVEENQHRVDGAEWGVD 525
Query: 1522 LGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDL 1581
L E + SH L HQ+I +A++ E+AR ++ ++
Sbjct: 526 LPSVEAQLGSHRGL---HQSIEEFRAKI--------------ERARSDEGQLSPATRGAY 568
Query: 1582 HILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLL 1641
RL+LQ LN K L K + L E E+ D S +
Sbjct: 569 RDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 628
Query: 1642 VKLKKVSQD-LERQREITELKVKEFEN--------------------------------- 1667
+ KK S L R+ E+ E K+KE +N
Sbjct: 629 MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 688
Query: 1668 ---IKLQLQENHE-----DEVKKVKAEVEDL------KYLLDQSQKESQC--LKSELQAQ 1711
I+ L+EN +V++ + +++ L KY D+S ++ L + Q +
Sbjct: 689 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 748
Query: 1712 KEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRA-----------------E 1754
KE + + L +R K+ + LK + R L L A +
Sbjct: 749 KEQLNEYKGH-LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQ 807
Query: 1755 MTAAAEE---RIISATSQKEAHLNVQQIV---DRHTRELKTQVEDLNENLLKLKEALKT- 1807
+ A+ +++S++ + A +V +V ++ +E T++E ++ L+ L L
Sbjct: 808 LVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 867
Query: 1808 --------SKNRENSL----------TDNLNDLNNELQKKQKAYNKILREKEEI------ 1843
S R+ L T + L + Y LR+ ++
Sbjct: 868 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 927
Query: 1844 -----DQENDELKRQIKRLTSGL-QGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDL 1897
++E ++L L QG Q I EL+ +LE V + L
Sbjct: 928 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 987
Query: 1898 KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEK 1957
P+ ++ A+E R E +K QA++EG+ + E +++ L + A
Sbjct: 988 -PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA----EKVLALPEPSPAAP--- 1039
Query: 1958 LTLQRKLKTTGMTVDQVLGIRALESEK-ELEELKKRNLDLENDILYMRAHQALPRDSVVE 2016
TL+ +L+ T ++QV + A+ EK + L R ++L RAH+ +++
Sbjct: 1040 -TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL--RAHEEQLKEAQAV 1096
Query: 2017 DLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELK 2076
L L+ +L+K ++ +P+ + D + QE+ + +L + E
Sbjct: 1097 PATLPE--LEATKASLKKLRAQAEAQQPTFDALR--DELRGAQEVGE---RLQQRHGERD 1149
Query: 2077 FQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS-GKTIPELEKTIG 2135
++E+ + + +L + + + + ++E ++ R+L + R S G + + +
Sbjct: 1150 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1209
Query: 2136 LMKKV-VEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG--HQLSMHY 2192
++ + + Q EQL++ +L IE+ EK++ K ++ +
Sbjct: 1210 QIQAMPLADSQAVREQLRQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQL 1264
Query: 2193 ESKTKGTEKIIAENERLRKELKKETDAAE--KLRIAKNNLEILNEKMTVQLEETGKRLQF 2250
+ E + + ++ + + E+ E LR + L L + + ET +R++
Sbjct: 1265 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1324
Query: 2251 AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKV 2310
E Q + + +L E+E + K+ Q + + K ERE K
Sbjct: 1325 EERLAEQQRAEERE-------------RLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKE 1370
Query: 2311 NKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSG 2370
+ E+ ++ + + + ++ ++ ELQ LR ++ +AE+ Q +A + ++
Sbjct: 1371 LQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQSS------EAEI--QAKARQAEAA 1421
Query: 2371 AESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYN 2430
S + +++E+I+ + QL+ ++ ++ + E++ L+ E E E K
Sbjct: 1422 ERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQALRARAE--------EAEAQKRQ 1469
Query: 2431 YKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEE 2471
+EE ++ + + Q VEL S V A E E++
Sbjct: 1470 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1510
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 171 bits (433), Expect = 8e-42
Identities = 351/1737 (20%), Positives = 727/1737 (41%), Gaps = 210/1737 (12%)
Query: 861 YNNLLNALQMDSDEMKKILAENSR-KITVLQVNEKSLIRQYTTLVELERQLRKENEKQKN 919
Y LL +L+ + E + S K LQ+ + + L+++ +E ++
Sbjct: 951 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1010
Query: 920 ELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSL-SELELAN---KQYNELTAK 975
E +AEV E +G K+ AL + + +L SELEL +Q L+A
Sbjct: 1011 EQQKAQAEV-EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1069
Query: 976 YRDILQKDNMLVQRTSNLEH-LECENISLKEQ--VESINKELEITKEKLHTIEQAWEQET 1032
Y + L+ +++++ T E L LKE V + ELE TK L + E +
Sbjct: 1070 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ- 1128
Query: 1033 KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE 1092
+ + D + + + V + E ER R E ++ E + L Q +
Sbjct: 1129 ----QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDV 1183
Query: 1093 RNFELETKFAELTKINLDAQKVEQMLRD-ELADSVSKAVSDADRQRILELEKNEMELKVE 1151
R ELE +L A + L+D +A+ AD Q + E + E L E
Sbjct: 1184 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1243
Query: 1152 VSKLRE-ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSD------EKSLIAKLH 1204
+ + E + + R + +NA ++ +QL+ Y+AQ + +K +
Sbjct: 1244 IERHGEKVEECQRFAKQYINA--------IKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1295
Query: 1205 QHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLR 1264
+ + + T +L ++TS+ K + LR +++E+E+ R E R R +
Sbjct: 1296 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERERLAEVE 1352
Query: 1265 QTIQSLRRQFSG-ALPLAQQEKFSKTMIQ-LQNDKLKIMQEMKNSQQEHRNMENKTLEME 1322
++ R+ A AQ E+ +K + Q +Q + ++ + ++QQ+ R+++ + +
Sbjct: 1353 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL--QQ 1410
Query: 1323 LKLKGLEELISTLKDTKGAQKVINWHMKIEE----LRLQELKLNRELVKDKEEIKYLNNI 1378
L+ E+ + + + A++ ++IEE +RLQ R+ + E++ L
Sbjct: 1411 LRQSSEAEIQAKARQAEAAERS---RLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1467
Query: 1379 ISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDI---FDRQQNEILNAAQKF 1435
E E +EE + + ++ Q EV+L ++ R++ L A ++
Sbjct: 1468 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1527
Query: 1436 ----EEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLA 1491
EEA + + Q+++AL + + L+++ S EK + E +L+
Sbjct: 1528 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA--SFAEKTAQLERSLQ-E 1584
Query: 1492 EQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQ 1551
E +++ + E R + A AER + AE + + K++ L++ Q Q Q
Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ----Q 1640
Query: 1552 KEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSP 1611
K + ++ E+A E R K E+ + R A+ L K +Q A +Q
Sbjct: 1641 KSLAQAEAEKQKEEAEREARRRGKAEEQAV-----RQRELAEQELEKQRQLAEGTAQQ-- 1693
Query: 1612 TPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFEN---I 1668
RLA AEQ+ L++L+ ++ E+QR++ E ++ +
Sbjct: 1694 ----------RLA------AEQE------LIRLRAETEQGEQQRQLLEEELARLQREAAA 1731
Query: 1669 KLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANS------RAPTTT 1722
Q ++ E E+ KV+AE+E L ++++ES+ + + + EA +
Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1791
Query: 1723 MRNLVERLKSQLALKE----KQQKALSRALLELRA---EMTAAAEERIISATSQKEAHLN 1775
+R L E K Q L E +Q+ R L E A E T E I+ ++ +
Sbjct: 1792 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1851
Query: 1776 VQQIVDRHT---RELKTQVE----DLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQK 1828
++++ + R L+ Q D+ E L +L++A + R+ L ++ L++
Sbjct: 1852 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------LRQ 1905
Query: 1829 KQKAYNKILREKEEIDQE---NDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE 1885
+++ +IL K ++ EL+ ++ R+ S + + + L QR++ E
Sbjct: 1906 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1965
Query: 1886 NQLEGKVEEVDLKPM--KEKNAKEELIRWEEGKKWQAKIEG---IRNKLKEKEGEVFTLT 1940
+ + EE K + +E+ A++ EE ++ +AK+E +R + +++ L
Sbjct: 1966 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2025
Query: 1941 K-------QLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGI---------------- 1977
+ Q FA KE+ LQ+ L+ +DQ+ G
Sbjct: 2026 QEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2084
Query: 1978 ----RALESEKELEELKKRNLDLENDI------------LYMRAHQALPRDSVVEDLHLQ 2021
A +S +++EE ++ E L A Q R + E L+
Sbjct: 2085 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2144
Query: 2022 NRYLQEKLHALEKQFSKDTY-SKPSISG--------IESDDHCQR--EQELQK------- 2063
+ + K+F++ T K + +E DH + ++ELQ+
Sbjct: 2145 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2204
Query: 2064 ---ENLKLSSENIELKFQLEQANKDLPRLKNQ-----VRDLKEMCEFLKKEKA---EVQR 2112
+ ++ E ++ Q+E+ +K R++ + +RD FL++E +V
Sbjct: 2205 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2264
Query: 2113 KLGHVRGSGRSGKTIPEL-EKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171
+ + + + + +L E+ + + + EK+ +E Q + + L +E A + Q+ +
Sbjct: 2265 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQK 2322
Query: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLE 2231
+L E + Q++ +T+G ++ + + + E+ E + KLR+A+ +
Sbjct: 2323 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMS-- 2379
Query: 2232 ILNEKMTVQLEETGKRLQF-AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN 2290
+ + EE +R + AE G +L + + + + + + E + ++ + D +
Sbjct: 2380 ----RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2435
Query: 2291 QSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQ 2350
++I +L++ KE ++E K+ + + Q ++ + + E +Q E L
Sbjct: 2436 EAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2494
Query: 2351 LDKEKAEL--IHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
+++EKA+L + Q E K Q E Q++++ + L ++ + + +E +++
Sbjct: 2495 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2554
Query: 2409 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELT-SPVAASE 2464
++EL+ + ++ E+L + +++ + L E+ + + E+T S VAA++
Sbjct: 2555 KQEELQQLEQQRRQQ-EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2610
Score = 145 bits (367), Expect = 4e-34
Identities = 388/1985 (19%), Positives = 766/1985 (38%), Gaps = 335/1985 (16%)
Query: 53 RITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRF 112
R+ L K A+E + E +KA E + + E L + + S
Sbjct: 992 RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT--- 1048
Query: 113 LRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKK 172
LR+E+ +LEQ R L + LEK K ++ L +R + E LR ++LK+
Sbjct: 1049 LRSELELTLGKLEQV-RSLSAIY--LEKLKTIS--LVIRGTQGAEE--VLRAHEEQLKE- 1100
Query: 173 NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKI 232
Q + ++++ K +L R + ++ + ++ ++ DE++ E E++
Sbjct: 1101 ----AQAVPATLPELEATKASLKKLRAQ-----AEAQQPTFDALR--DELRGAQEVGERL 1149
Query: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTD---NVIDQLKKENDHYQLQVQELT 289
+ ++ E +E + E++ R +A++ QTD ++QL ++ +Y+ L
Sbjct: 1150 QQRHGERDVEVE---RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1206
Query: 290 DLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLR---EKLKNAQLDAD 346
L+ + I A + + +++ + Q +L + EK++ Q A
Sbjct: 1207 AWLQDARRRQEQIQAMPLADSQAVR-------EQLRQEQALLEEIERHGEKVEECQRFA- 1258
Query: 347 KSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEK------NTCIIEDLKNELQRNKGAST 400
K + A I++ + Q+ Q+E +K + +I++ + +T
Sbjct: 1259 KQYINA----IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1314
Query: 401 LSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDY-ESGVYGLE 459
L+ Q I TL + +E ER AE A+ RE+ E+ AL++ + E+
Sbjct: 1315 LTSQYIKFISETL----RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1370
Query: 460 DAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTE 519
A E K + +++ +E+ + E D + +++E +L +
Sbjct: 1371 QAEREAKELQQRMQ----------EEVVRREEAAVDAQQQKRSIQE----------ELQQ 1410
Query: 520 FRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQM-----AQERGKRSATSGLTT 574
R S AE Q ++ E+ E RL ++++IR + A ER + A L
Sbjct: 1411 LRQSSE-------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1463
Query: 575 EDLNLTENISQGDRISERKLDLLSLKNMSEAQSKN----EFLSRELIEKERDLERSRTVI 630
E +Q R ++ + + L + E+Q K E SR E E E+ R
Sbjct: 1464 LRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-- 1520
Query: 631 AKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNA-IESK 689
L+ L E Q EE + + QA E + + + + + +R A ++SK
Sbjct: 1521 ------LQALEELRLQAEEAERRLRQAEVERAR-------QVQVALETAQRSAEAELQSK 1567
Query: 690 NAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSL 749
A + QL +E + + R+EA +QQ A+A + E+E
Sbjct: 1568 RAS--------FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1619
Query: 750 --LRQSEGSNVVFKGIDLPD--GIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSL 805
L+ +E + + ++ +A + A + E + E + + + L +
Sbjct: 1620 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1679
Query: 806 EDYNRKFAVIRHQQSLLYKEYL----SEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEY 861
+ R+ A QQ L ++ L +E E + + + ++EE +L+ + K +E
Sbjct: 1680 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1739
Query: 862 NNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNEL 921
L ++ EM+ +LA +R E + R +EK K L
Sbjct: 1740 EAELAKVRA---EMEVLLASKARA---------------------EEESRSTSEKSKQRL 1775
Query: 922 LSMEAEVCEKIGCLQRFKEMA--IFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI 979
EAE RF+E+A ++ AL + L+E + A ++
Sbjct: 1776 ---EAEA-------GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----------- 1814
Query: 980 LQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTI-EQAWEQETKLGNES 1038
+ + +L ++ + + E LK + E KE E E+L + E Q +L ++
Sbjct: 1815 AEAERVLAEKLAAIG----EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1870
Query: 1039 SMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1098
+ KA I +++ L +E +R + + E +Q+EE L+
Sbjct: 1871 AQHKA----------DIEERLAQLRKASDSELERQKG---LVEDTLRQRRQVEEEILALK 1917
Query: 1099 TKF----AELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELE----KNEMELKV 1150
F A ++ L+ ++ D L S +A +A RQR L E + E E +V
Sbjct: 1918 ASFEKAAAGKAELELELGRIRSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERV 1976
Query: 1151 EVSKLRE----------ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLI 1200
+ S E + ++ R + ++ A++ E ES R L +A +K L
Sbjct: 1977 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA--QKRLQ 2034
Query: 1201 AKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA 1260
A+ H ++Q E L+ S L ++ + +E E+A R++ A
Sbjct: 2035 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA----RVQAEREA 2090
Query: 1261 KHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLE 1320
R+ ++ R A AQ ++ Q +KL+ K E
Sbjct: 2091 AQSRRQVEEAERLKQSAEEQAQ----ARAQAQAAAEKLR-----------------KEAE 2129
Query: 1321 MELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIIS 1380
E + E + L+ + A + H K E L R+ + ++E+ L +
Sbjct: 2130 QEAARRAQAEQ-AALRQKQAADAEMEKHKKFAEQTL------RQKAQVEQELTTLRLQLE 2182
Query: 1381 EYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG 1440
E + + L+EE+ + E A QR + + E+ + + EE
Sbjct: 2183 ETDHQKNLLDEEL---QRLKAEATEAARQRS-----------QVEEELFSVRVQMEE--- 2225
Query: 1441 SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK 1500
L K+K RI E RA L++K++ R ++ + K
Sbjct: 2226 ----------------LSKLKA--RIEAENRALI------LRDKDNTQRFLQEEA-EKMK 2260
Query: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
+ E RL A+ + +L +++ + K+ + + +Q K E
Sbjct: 2261 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA----- 2315
Query: 1561 RLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF 1620
LL++ +E +E ++ +ED + +L A+ + + + +Q +
Sbjct: 2316 ELLQQQKELAQEQARRLQEDKEQMAQQL---AEETQGFQRTLEAERQRQLEMSAEAERLK 2372
Query: 1621 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHED-- 1678
+R+AEM + A ++ + +++ + L R T+ KV + +++Q Q++ D
Sbjct: 2373 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2432
Query: 1679 EVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738
+++ AE+E K L Q K Q E+Q ++ T ++ K L +E
Sbjct: 2433 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2492
Query: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENL 1798
R + + +A++ ++ + A +E QQ +++ + L +E+
Sbjct: 2493 -------RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2545
Query: 1799 LKLKEALKTS-----------KNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEN 1847
+ +E ++ + +E L + L +LQ ++ + L EE+
Sbjct: 2546 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2605
Query: 1848 DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKE 1907
+ + L G + + L+RKV Q G + +L+ + + +
Sbjct: 2606 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTV 2665
Query: 1908 ELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLT----LQRK 1963
+ + A+ E +R+ L+ + +++ L KA EKL+ LQR+
Sbjct: 2666 DEL---------ARREDVRHYLQGR-----------SSIAGLLLKATNEKLSVYAALQRQ 2705
Query: 1964 LKTTG 1968
L + G
Sbjct: 2706 LLSPG 2710
Score = 137 bits (346), Expect = 1e-31
Identities = 374/2011 (18%), Positives = 809/2011 (40%), Gaps = 281/2011 (13%)
Query: 641 VEENKQLEEG----MKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696
V+ +LE+ ++++L ++E Q D G E + +PS+E + + G+
Sbjct: 497 VQRRPELEDSTLRYLQDLLAWVEENQHRVD--GAEWGVDLPSVEAQLGS-----HRGLHQ 549
Query: 697 ASLHLKAQVDQLTGRNEELRQELRESRKEAIN-----YSQQLAKANLKIDHLE------- 744
+ +A++++ +L R + ++ + Y++ L + ++ LE
Sbjct: 550 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVA 609
Query: 745 ---KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNL 801
KE L + E V F D + ++ E L++ELE KEKK+K L
Sbjct: 610 AATKELMWLNEKEEEEVGFDWSDRNTNMT--------AKKESYSALMRELELKEKKIKEL 661
Query: 802 EDS-----LEDYNRKFAVIRHQQSL------------LYKEYLSEKETWKTESKTIKEEK 844
+++ ED+ + V Q +L + +L E + ++E +
Sbjct: 662 QNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAE 721
Query: 845 RKLEDQVQQDAIKVKEYN-------NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
+L Q Q+A++ ++Y+ L L D+ + K+ L E ++ L K+++
Sbjct: 722 GQL--QKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 778
Query: 898 ----RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953
R + L + ++ E+ + + C+ +G Q + + + V
Sbjct: 779 QLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQP-SHWKVLSSSGSEAAV 837
Query: 954 DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENI----SLKEQVES 1009
+ L + N++ E + L+ + + + H++ +++ SL+ V+
Sbjct: 838 PSVCFL--VPPPNQEAQEAVTR----LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 891
Query: 1010 INK---------ELEITKEKLHTIE---QAWEQETKLGNESSMDKAKKSITNSDIVSISK 1057
I + E ++ LH++E QA+ ++++ + + + + S S
Sbjct: 892 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQ--DAGGFGPEDRLMAEREYGSCSH 949
Query: 1058 KITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLD------- 1110
L Q CQ+ L+ Q+E ET+ ++ LD
Sbjct: 950 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE----ACETRTVHRLRLPLDKEPAREC 1005
Query: 1111 AQKV-EQMLRDELADSVSKAVS--DADRQRILELE---------KNEMELKV-EVSKLRE 1157
AQ++ EQ + + K V+ A+ +++L L ++E+EL + ++ ++R
Sbjct: 1006 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1065
Query: 1158 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA 1217
+S I +++ ++ + E LR + + + +L SL+ A A
Sbjct: 1066 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1125
Query: 1218 LGK---LESITSKLQKMEAYNLRLEQKLDEKEQALYYAR--------------LEGRNRA 1260
+ +++ +L+ + RL+Q+ E++ + R + R
Sbjct: 1126 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1185
Query: 1261 KHLRQTIQSLRRQFSGALPLA---QQEKFSKTMIQLQ--NDKLKIMQEMKNSQQEHRNME 1315
+ L Q + LR A PL Q + + IQ D + ++++ Q +E
Sbjct: 1186 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1245
Query: 1316 NKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELK---------LNRELV 1366
++E + ++ I+ +KD + +++ + ++E + K + +E V
Sbjct: 1246 RHGEKVEECQRFAKQYINAIKDYE--LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1303
Query: 1367 KDKEEIKYLNNIISEYERTISSL------EEEIVQQNKFHEERQMAWDQREVDLERQLDI 1420
+ L + S+Y + IS EE + +Q + E ++A + E LE+Q +
Sbjct: 1304 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQL 1361
Query: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEK 1480
+ A ++ +E + + + + E A+ ++ I E + +S E +
Sbjct: 1362 AEAHAQAKAQAEREAKELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1418
Query: 1481 LKEKESALRLAEQNILSRDKVINELRLRLPAT------AEREKLIAELGRKEMEPKSHHT 1534
++ K AE++ L ++ I +RL+L AT AE E +E E +
Sbjct: 1419 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1478
Query: 1535 LKIAHQTIANMQARLNQKE----EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 1590
+ A + +Q +K E+ + + E ARE+QR + E L L
Sbjct: 1479 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---------LRL 1529
Query: 1591 QADSSLNKFKQTAWDLMKQSPTPVPTNKHFI------RLAEMEQTVAEQDDSLSSLLVKL 1644
QA+ + + +Q + +Q + T + + A + A+ + SL V +
Sbjct: 1530 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1589
Query: 1645 KKVSQDLER--QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDL--KYLLDQSQKE 1700
++ ++ ER Q++ + +E +L+ + +E +++ + E++ + L Q++ E
Sbjct: 1590 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1649
Query: 1701 SQCLKSELQAQKEANSRAPTTTMRNLVER-LKSQLALKE---KQQKALSRALLELRAEMT 1756
Q ++E +A++ + R L E+ L+ Q L E +Q+ A + L+ LRAE
Sbjct: 1650 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1709
Query: 1757 AAAEERII----SATSQKEAHLNVQ--QIVDRHTRELKTQVEDLNENLLKLKEALKT--- 1807
++R + A Q+EA Q Q ++ +++ ++E L + + +E ++
Sbjct: 1710 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1769
Query: 1808 -SKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPL 1866
SK R + +L E + + + R+++ +++ + + +R+ +
Sbjct: 1770 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA------- 1822
Query: 1867 TDNKQSLIEELQRKVKKLENQL-EGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIE-- 1923
K + I E R + E L E + E L+ + E A + E+ + +A IE
Sbjct: 1823 --EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1880
Query: 1924 ------GIRNKLKEKEGEVFTLTKQ-------LNTLKDLFAKADKEKLTLQRKLKTTGMT 1970
++L+ ++G V +Q + LK F KA K L+ +L
Sbjct: 1881 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1940
Query: 1971 VDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLH 2030
+ L + + ELE ++R L E + A + + + E+ + R + L
Sbjct: 1941 AEDTL---RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALE 1995
Query: 2031 ALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQ-ANKDLPRL 2089
+E+ +K E+ +R ++ L+L+ E + + Q E+ A+ +
Sbjct: 1996 EVERLKAKVE---------EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2046
Query: 2090 KNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENE 2149
K Q E+ + L++E++ + + G + R+ + E +VQ E E
Sbjct: 2047 KEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------------ARVQAERE 2089
Query: 2150 QLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERL 2209
+ + +E++ +E + +A+ + L + + + + + + +
Sbjct: 2090 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2149
Query: 2210 RKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETG--KRLQFAESRGPQLEGADSKSWK 2267
E++K AE+ K +E + +QLEET K L E + + E ++ +
Sbjct: 2150 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2209
Query: 2268 SIVVTRMYETK-----LKELETDIAKKNQSITDLKQLVKEATER--EQKVNKYNEDLEQQ 2320
S V ++ + L +L+ I +N+++ L+ K+ T+R +++ K + E+
Sbjct: 2210 SQVEEELFSVRVQMEELSKLKARIEAENRALI-LRD--KDNTQRFLQEEAEKMKQVAEEA 2266
Query: 2321 IKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQ 2380
++ E A Q + +L R ++ KEK + + EA + ++ AE +
Sbjct: 2267 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKEL 2324
Query: 2381 LKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFE---EIEDLKYNYKEEVKK 2437
+E+ + L+ + Q L EE + ++ LE E E E LK E +
Sbjct: 2325 AQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2381
Query: 2438 NILLEE---KVKKLSEQLGVELTSPVAASEE 2465
EE + +K +E++G +L A++E
Sbjct: 2382 QARAEEDAQRFRKQAEEIGEKLHRTELATQE 2412
Score = 130 bits (327), Expect = 2e-29
Identities = 247/1349 (18%), Positives = 554/1349 (41%), Gaps = 139/1349 (10%)
Query: 39 ELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL 98
E EKQ + ++ + +A+E++ ++E EE A Q K + + +L
Sbjct: 1352 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1411
Query: 99 EMA----------QQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQL 148
+ Q A R + EI + QLE +R+ E EL+ + E+
Sbjct: 1412 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1471
Query: 149 ALRNEEAENENSKLRR----ENKRLKKKNEQLCQDI-------IDYQKQIDSQKETLLSR 197
+ +A+ E +LRR E++R ++ +L + + Q+ + + +E L
Sbjct: 1472 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1531
Query: 198 RGEDSDYRSQLSKKNYELIQYLDEIQTLTEAN-EKIEVQNQEMRKNLEESVQE----MEK 252
+ R ++ ++ L+ Q EA + E LE S+QE + +
Sbjct: 1532 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1591
Query: 253 MTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDL-LKSKNEEDDPIMVAVNAKVE 311
+ +E R + + ++ ++E + +QL+ E L L+++ + A+ +
Sbjct: 1592 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1651
Query: 312 EWKLILSSK-----DDEIIEYQQMLHNLREKLKN------AQLDADKSNVMALQQGIQER 360
+ + ++ +++ + +++ EK + Q A + ++ L+ ++
Sbjct: 1652 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1711
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQR---------------NKGASTLSQQT 405
+ Q ++L E++ + +E T ++L+ EL + + + + S+++
Sbjct: 1712 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1771
Query: 406 HMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEI 465
++++ +E +EA R LAE R++ +A ++ + E + A+ E
Sbjct: 1772 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1831
Query: 466 KNCKNQIKIRDREIEILTKEINKL--ELKISDFLDENEALRERVGLEPKTMIDLTEFRNS 523
K + +I +E E + + +L + E +A + + +E + L + R +
Sbjct: 1832 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKA 1887
Query: 524 KHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSG---LTTEDLNLT 580
+ ++ + + L++ +EEE L LK + A + + G ED +
Sbjct: 1888 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1947
Query: 581 ENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKEL 640
+ ++ + +R+L + EA+ + ++ + E + R R + +LK
Sbjct: 1948 KEQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAK 2003
Query: 641 VEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLH 700
VEE ++L E ++ ++ +++Q E + E +A + E +L
Sbjct: 2004 VEEARRLRERAEQ--ESARQLQ-----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2056
Query: 701 LKAQV-DQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVV 759
+ V DQL G E R+ E+ + + ++ A++ +++ E+ L+QS
Sbjct: 2057 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER----LKQSAEEQAQ 2112
Query: 760 FKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQ 819
+ A ++A + + E + E + K D+ + ++KFA +Q
Sbjct: 2113 AR------AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2166
Query: 820 SLLYKEYLS----EKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEM 875
++ L+ + E + + EE ++L+ + + A + + L ++++ +E+
Sbjct: 2167 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2226
Query: 876 KKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEA----EVCEK 931
K+ A + L + +K +++ E E+ + E + + + EA ++ E+
Sbjct: 2227 SKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2285
Query: 932 IGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTS 991
QR + K +Q V + + +E EL +Q EL + LQ+D + +
Sbjct: 2286 DLAQQRALAEKMLK-EKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQL 2343
Query: 992 NLEHLECENISLKEQVESINKELEITKEKLHTIE----QAWEQETKLGNESSMDKAKKSI 1047
E + E+ + E + KL E QA +E ++ + +
Sbjct: 2344 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2403
Query: 1048 TNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFEL--ETKFAELT 1105
+++ + +K+T+++ E+ +RQ+++H E LR ++ ++E +L E K +L
Sbjct: 2404 HRTELAT-QEKVTLVQTLEI-QRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLK 2458
Query: 1106 KINLDAQKVEQMLRDELA---DSVSKAVSDADRQRILELEKNEME--LKVEVSKLREISD 1160
+ + EQ+L++ A +S+ S R+R +E EK ++E + EV+K +++ +
Sbjct: 2459 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2518
Query: 1161 IARRQVEILNAQQQSRDKEVESLR----------------MQLLDYQAQSDEKSLIAKLH 1204
+RQ + + ++Q +E R +Q L+ Q + E+ L +
Sbjct: 2519 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2578
Query: 1205 QHNVSLQLSE---ATALGKLESITSKLQKMEAYNLRLEQKLDEKEQAL--YYARLEGRNR 1259
+ LQL E AL E +T A + + L AL A E +
Sbjct: 2579 RLREQLQLLEEQHRAALAHSEEVT-------ASQVAATKTLPNGRDALDGPAAEAEPEHS 2631
Query: 1260 AKHLRQTIQSLRRQFSGALPLAQQEKFSK 1288
LR+ + + R Q +G L + ++ ++
Sbjct: 2632 FDGLRRKVSAQRLQEAGILSAEELQRLAQ 2660
Score = 53.9 bits (128), Expect = 2e-06
Identities = 233/1241 (18%), Positives = 475/1241 (38%), Gaps = 202/1241 (16%)
Query: 1353 ELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEE--RQMAWD-- 1408
+L + L+ ++L + E ++ L I+++ + EE++ Q + + R +A
Sbjct: 358 KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKV 417
Query: 1409 -QREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRII 1467
QR ++ER LD D + N Q ++ + +L L I+ +
Sbjct: 418 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 477
Query: 1468 LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLI------AE 1521
L+ + + +S R E D + L+ L E + + +
Sbjct: 478 LKAGVAAPATQVAQVTLQSVQRRPELE----DSTLRYLQDLLAWVEENQHRVDGAEWGVD 533
Query: 1522 LGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDL 1581
L E + SH L HQ+I +A++ E+AR ++ ++
Sbjct: 534 LPSVEAQLGSHRGL---HQSIEEFRAKI--------------ERARSDEGQLSPATRGAY 576
Query: 1582 HILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLL 1641
RL+LQ LN K L K + L E E+ D S +
Sbjct: 577 RDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 636
Query: 1642 VKLKKVSQD-LERQREITELKVKEFEN--------------------------------- 1667
+ KK S L R+ E+ E K+KE +N
Sbjct: 637 MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 696
Query: 1668 ---IKLQLQENHE-----DEVKKVKAEVEDL------KYLLDQSQKESQC--LKSELQAQ 1711
I+ L+EN +V++ + +++ L KY D+S ++ L + Q +
Sbjct: 697 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 756
Query: 1712 KEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRA-----------------E 1754
KE + + L +R K+ + LK + R L L A +
Sbjct: 757 KEQLNEYKGH-LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQ 815
Query: 1755 MTAAAEE---RIISATSQKEAHLNVQQIV---DRHTRELKTQVEDLNENLLKLKEALKT- 1807
+ A+ +++S++ + A +V +V ++ +E T++E ++ L+ L L
Sbjct: 816 LVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 875
Query: 1808 --------SKNRENSL----------TDNLNDLNNELQKKQKAYNKILREKEEI------ 1843
S R+ L T + L + Y LR+ ++
Sbjct: 876 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 935
Query: 1844 -----DQENDELKRQIKRLTSGL-QGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDL 1897
++E ++L L QG Q I EL+ +LE V + L
Sbjct: 936 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 995
Query: 1898 KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEK 1957
P+ ++ A+E R E +K QA++EG+ + E +++ L + A
Sbjct: 996 -PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA----EKVLALPEPSPAAP--- 1047
Query: 1958 LTLQRKLKTTGMTVDQVLGIRALESEK-ELEELKKRNLDLENDILYMRAHQALPRDSVVE 2016
TL+ +L+ T ++QV + A+ EK + L R ++L RAH+ +++
Sbjct: 1048 -TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL--RAHEEQLKEAQAV 1104
Query: 2017 DLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELK 2076
L L+ +L+K ++ +P+ + D + QE+ + +L + E
Sbjct: 1105 PATLPE--LEATKASLKKLRAQAEAQQPTFDALR--DELRGAQEVGE---RLQQRHGERD 1157
Query: 2077 FQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS-GKTIPELEKTIG 2135
++E+ + + +L + + + + ++E ++ R+L + R S G + + +
Sbjct: 1158 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1217
Query: 2136 LMKKV-VEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG--HQLSMHY 2192
++ + + Q EQL++ +L IE+ EK++ K ++ +
Sbjct: 1218 QIQAMPLADSQAVREQLRQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQL 1272
Query: 2193 ESKTKGTEKIIAENERLRKELKKETDAAE--KLRIAKNNLEILNEKMTVQLEETGKRLQF 2250
+ E + + ++ + + E+ E LR + L L + + ET +R++
Sbjct: 1273 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1332
Query: 2251 AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKV 2310
E Q + + +L E+E + K+ Q + + K ERE K
Sbjct: 1333 EERLAEQQRAEERE-------------RLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKE 1378
Query: 2311 NKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSG 2370
+ E+ ++ + + + ++ ++ ELQ LR ++ +AE+ Q +A + ++
Sbjct: 1379 LQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQSS------EAEI--QAKARQAEAA 1429
Query: 2371 AESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYN 2430
S + +++E+I+ + QL+ ++ ++ + E++ L+ E E E K
Sbjct: 1430 ERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQALRARAE--------EAEAQKRQ 1477
Query: 2431 YKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEE 2471
+EE ++ + + Q VEL S V A E E++
Sbjct: 1478 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1518
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 171 bits (433), Expect = 8e-42
Identities = 351/1737 (20%), Positives = 727/1737 (41%), Gaps = 210/1737 (12%)
Query: 861 YNNLLNALQMDSDEMKKILAENSR-KITVLQVNEKSLIRQYTTLVELERQLRKENEKQKN 919
Y LL +L+ + E + S K LQ+ + + L+++ +E ++
Sbjct: 992 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1051
Query: 920 ELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSL-SELELAN---KQYNELTAK 975
E +AEV E +G K+ AL + + +L SELEL +Q L+A
Sbjct: 1052 EQQKAQAEV-EGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1110
Query: 976 YRDILQKDNMLVQRTSNLEH-LECENISLKEQ--VESINKELEITKEKLHTIEQAWEQET 1032
Y + L+ +++++ T E L LKE V + ELE TK L + E +
Sbjct: 1111 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ- 1169
Query: 1033 KLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEE 1092
+ + D + + + V + E ER R E ++ E + L Q +
Sbjct: 1170 ----QPTFDALRDELRGAQEVGERLQQRHGERDVEVERWR-ERVAQLLERWQAVLAQTDV 1224
Query: 1093 RNFELETKFAELTKINLDAQKVEQMLRD-ELADSVSKAVSDADRQRILELEKNEMELKVE 1151
R ELE +L A + L+D +A+ AD Q + E + E L E
Sbjct: 1225 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1284
Query: 1152 VSKLRE-ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSD------EKSLIAKLH 1204
+ + E + + R + +NA ++ +QL+ Y+AQ + +K +
Sbjct: 1285 IERHGEKVEECQRFAKQYINA--------IKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1336
Query: 1205 QHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLR 1264
+ + + T +L ++TS+ K + LR +++E+E+ R E R R +
Sbjct: 1337 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLR---RMEEEERLAEQQRAEERERLAEVE 1393
Query: 1265 QTIQSLRRQFSG-ALPLAQQEKFSKTMIQ-LQNDKLKIMQEMKNSQQEHRNMENKTLEME 1322
++ R+ A AQ E+ +K + Q +Q + ++ + ++QQ+ R+++ + +
Sbjct: 1394 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL--QQ 1451
Query: 1323 LKLKGLEELISTLKDTKGAQKVINWHMKIEE----LRLQELKLNRELVKDKEEIKYLNNI 1378
L+ E+ + + + A++ ++IEE +RLQ R+ + E++ L
Sbjct: 1452 LRQSSEAEIQAKARQAEAAERS---RLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1508
Query: 1379 ISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDI---FDRQQNEILNAAQKF 1435
E E +EE + + ++ Q EV+L ++ R++ L A ++
Sbjct: 1509 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1568
Query: 1436 ----EEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLA 1491
EEA + + Q+++AL + + L+++ S EK + E +L+
Sbjct: 1569 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRA--SFAEKTAQLERSLQ-E 1625
Query: 1492 EQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQ 1551
E +++ + E R + A AER + AE + + K++ L++ Q Q Q
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ----Q 1681
Query: 1552 KEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSP 1611
K + ++ E+A E R K E+ + R A+ L K +Q A +Q
Sbjct: 1682 KSLAQAEAEKQKEEAEREARRRGKAEEQAV-----RQRELAEQELEKQRQLAEGTAQQ-- 1734
Query: 1612 TPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFEN---I 1668
RLA AEQ+ L++L+ ++ E+QR++ E ++ +
Sbjct: 1735 ----------RLA------AEQE------LIRLRAETEQGEQQRQLLEEELARLQREAAA 1772
Query: 1669 KLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANS------RAPTTT 1722
Q ++ E E+ KV+AE+E L ++++ES+ + + + EA +
Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1832
Query: 1723 MRNLVERLKSQLALKE----KQQKALSRALLELRA---EMTAAAEERIISATSQKEAHLN 1775
+R L E K Q L E +Q+ R L E A E T E I+ ++ +
Sbjct: 1833 LRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENER 1892
Query: 1776 VQQIVDRHT---RELKTQVE----DLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQK 1828
++++ + R L+ Q D+ E L +L++A + R+ L ++ L++
Sbjct: 1893 LRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT------LRQ 1946
Query: 1829 KQKAYNKILREKEEIDQE---NDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE 1885
+++ +IL K ++ EL+ ++ R+ S + + + L QR++ E
Sbjct: 1947 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2006
Query: 1886 NQLEGKVEEVDLKPM--KEKNAKEELIRWEEGKKWQAKIEG---IRNKLKEKEGEVFTLT 1940
+ + EE K + +E+ A++ EE ++ +AK+E +R + +++ L
Sbjct: 2007 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2066
Query: 1941 K-------QLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGI---------------- 1977
+ Q FA KE+ LQ+ L+ +DQ+ G
Sbjct: 2067 QEAAQKRLQAEEKAHAFAVQQKEQ-ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2125
Query: 1978 ----RALESEKELEELKKRNLDLENDI------------LYMRAHQALPRDSVVEDLHLQ 2021
A +S +++EE ++ E L A Q R + E L+
Sbjct: 2126 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2185
Query: 2022 NRYLQEKLHALEKQFSKDTY-SKPSISG--------IESDDHCQR--EQELQK------- 2063
+ + K+F++ T K + +E DH + ++ELQ+
Sbjct: 2186 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2245
Query: 2064 ---ENLKLSSENIELKFQLEQANKDLPRLKNQ-----VRDLKEMCEFLKKEKA---EVQR 2112
+ ++ E ++ Q+E+ +K R++ + +RD FL++E +V
Sbjct: 2246 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAE 2305
Query: 2113 KLGHVRGSGRSGKTIPEL-EKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171
+ + + + + +L E+ + + + EK+ +E Q + + L +E A + Q+ +
Sbjct: 2306 EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQK 2363
Query: 2172 KLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLE 2231
+L E + Q++ +T+G ++ + + + E+ E + KLR+A+ +
Sbjct: 2364 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL-KLRVAEMS-- 2420
Query: 2232 ILNEKMTVQLEETGKRLQF-AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKN 2290
+ + EE +R + AE G +L + + + + + + E + ++ + D +
Sbjct: 2421 ----RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2476
Query: 2291 QSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQ 2350
++I +L++ KE ++E K+ + + Q ++ + + E +Q E L
Sbjct: 2477 EAIAELER-EKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF 2535
Query: 2351 LDKEKAEL--IHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKK 2408
+++EKA+L + Q E K Q E Q++++ + L ++ + + +E +++
Sbjct: 2536 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2595
Query: 2409 LKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELT-SPVAASE 2464
++EL+ + ++ E+L + +++ + L E+ + + E+T S VAA++
Sbjct: 2596 KQEELQQLEQQRRQQ-EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2651
Score = 145 bits (367), Expect = 4e-34
Identities = 388/1985 (19%), Positives = 766/1985 (38%), Gaps = 335/1985 (16%)
Query: 53 RITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRF 112
R+ L K A+E + E +KA E + + E L + + S
Sbjct: 1033 RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT--- 1089
Query: 113 LRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKK 172
LR+E+ +LEQ R L + LEK K ++ L +R + E LR ++LK+
Sbjct: 1090 LRSELELTLGKLEQV-RSLSAIY--LEKLKTIS--LVIRGTQGAEE--VLRAHEEQLKE- 1141
Query: 173 NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKI 232
Q + ++++ K +L R + ++ + ++ ++ DE++ E E++
Sbjct: 1142 ----AQAVPATLPELEATKASLKKLRAQ-----AEAQQPTFDALR--DELRGAQEVGERL 1190
Query: 233 EVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTD---NVIDQLKKENDHYQLQVQELT 289
+ ++ E +E + E++ R +A++ QTD ++QL ++ +Y+ L
Sbjct: 1191 QQRHGERDVEVE---RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLG 1247
Query: 290 DLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLR---EKLKNAQLDAD 346
L+ + I A + + +++ + Q +L + EK++ Q A
Sbjct: 1248 AWLQDARRRQEQIQAMPLADSQAVR-------EQLRQEQALLEEIERHGEKVEECQRFA- 1299
Query: 347 KSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEK------NTCIIEDLKNELQRNKGAST 400
K + A I++ + Q+ Q+E +K + +I++ + +T
Sbjct: 1300 KQYINA----IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTT 1355
Query: 401 LSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDY-ESGVYGLE 459
L+ Q I TL + +E ER AE A+ RE+ E+ AL++ + E+
Sbjct: 1356 LTSQYIKFISETL----RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKA 1411
Query: 460 DAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTE 519
A E K + +++ +E+ + E D + +++E +L +
Sbjct: 1412 QAEREAKELQQRMQ----------EEVVRREEAAVDAQQQKRSIQE----------ELQQ 1451
Query: 520 FRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQM-----AQERGKRSATSGLTT 574
R S AE Q ++ E+ E RL ++++IR + A ER + A L
Sbjct: 1452 LRQSSE-------AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1504
Query: 575 EDLNLTENISQGDRISERKLDLLSLKNMSEAQSKN----EFLSRELIEKERDLERSRTVI 630
E +Q R ++ + + L + E+Q K E SR E E E+ R
Sbjct: 1505 LRARAEEAEAQ-KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA-- 1561
Query: 631 AKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNA-IESK 689
L+ L E Q EE + + QA E + + + + + +R A ++SK
Sbjct: 1562 ------LQALEELRLQAEEAERRLRQAEVERAR-------QVQVALETAQRSAEAELQSK 1608
Query: 690 NAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSL 749
A + QL +E + + R+EA +QQ A+A + E+E
Sbjct: 1609 RAS--------FAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1660
Query: 750 --LRQSEGSNVVFKGIDLPD--GIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSL 805
L+ +E + + ++ +A + A + E + E + + + L +
Sbjct: 1661 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1720
Query: 806 EDYNRKFAVIRHQQSLLYKEYL----SEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEY 861
+ R+ A QQ L ++ L +E E + + + ++EE +L+ + K +E
Sbjct: 1721 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQEL 1780
Query: 862 NNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNEL 921
L ++ EM+ +LA +R E + R +EK K L
Sbjct: 1781 EAELAKVRA---EMEVLLASKARA---------------------EEESRSTSEKSKQRL 1816
Query: 922 LSMEAEVCEKIGCLQRFKEMA--IFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI 979
EAE RF+E+A ++ AL + L+E + A ++
Sbjct: 1817 ---EAEA-------GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR----------- 1855
Query: 980 LQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTI-EQAWEQETKLGNES 1038
+ + +L ++ + + E LK + E KE E E+L + E Q +L ++
Sbjct: 1856 AEAERVLAEKLAAIG----EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1911
Query: 1039 SMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELE 1098
+ KA I +++ L +E +R + + E +Q+EE L+
Sbjct: 1912 AQHKA----------DIEERLAQLRKASDSELERQKG---LVEDTLRQRRQVEEEILALK 1958
Query: 1099 TKF----AELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELE----KNEMELKV 1150
F A ++ L+ ++ D L S +A +A RQR L E + E E +V
Sbjct: 1959 ASFEKAAAGKAELELELGRIRSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERV 2017
Query: 1151 EVSKLRE----------ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLI 1200
+ S E + ++ R + ++ A++ E ES R L +A +K L
Sbjct: 2018 QKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA--QKRLQ 2075
Query: 1201 AKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRA 1260
A+ H ++Q E L+ S L ++ + +E E+A R++ A
Sbjct: 2076 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEA----RVQAEREA 2131
Query: 1261 KHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLE 1320
R+ ++ R A AQ ++ Q +KL+ K E
Sbjct: 2132 AQSRRQVEEAERLKQSAEEQAQ----ARAQAQAAAEKLR-----------------KEAE 2170
Query: 1321 MELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIIS 1380
E + E + L+ + A + H K E L R+ + ++E+ L +
Sbjct: 2171 QEAARRAQAEQ-AALRQKQAADAEMEKHKKFAEQTL------RQKAQVEQELTTLRLQLE 2223
Query: 1381 EYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG 1440
E + + L+EE+ + E A QR + + E+ + + EE
Sbjct: 2224 ETDHQKNLLDEEL---QRLKAEATEAARQRS-----------QVEEELFSVRVQMEE--- 2266
Query: 1441 SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK 1500
L K+K RI E RA L++K++ R ++ + K
Sbjct: 2267 ----------------LSKLKA--RIEAENRALI------LRDKDNTQRFLQEEA-EKMK 2301
Query: 1501 VINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQ 1560
+ E RL A+ + +L +++ + K+ + + +Q K E
Sbjct: 2302 QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA----- 2356
Query: 1561 RLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHF 1620
LL++ +E +E ++ +ED + +L A+ + + + +Q +
Sbjct: 2357 ELLQQQKELAQEQARRLQEDKEQMAQQL---AEETQGFQRTLEAERQRQLEMSAEAERLK 2413
Query: 1621 IRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHED-- 1678
+R+AEM + A ++ + +++ + L R T+ KV + +++Q Q++ D
Sbjct: 2414 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2473
Query: 1679 EVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKE 1738
+++ AE+E K L Q K Q E+Q ++ T ++ K L +E
Sbjct: 2474 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2533
Query: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENL 1798
R + + +A++ ++ + A +E QQ +++ + L +E+
Sbjct: 2534 -------RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQ 2586
Query: 1799 LKLKEALKTS-----------KNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQEN 1847
+ +E ++ + +E L + L +LQ ++ + L EE+
Sbjct: 2587 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2646
Query: 1848 DELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKE 1907
+ + L G + + L+RKV Q G + +L+ + + +
Sbjct: 2647 VAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTV 2706
Query: 1908 ELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLT----LQRK 1963
+ + A+ E +R+ L+ + +++ L KA EKL+ LQR+
Sbjct: 2707 DEL---------ARREDVRHYLQGR-----------SSIAGLLLKATNEKLSVYAALQRQ 2746
Query: 1964 LKTTG 1968
L + G
Sbjct: 2747 LLSPG 2751
Score = 137 bits (346), Expect = 1e-31
Identities = 374/2011 (18%), Positives = 809/2011 (40%), Gaps = 281/2011 (13%)
Query: 641 VEENKQLEEG----MKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696
V+ +LE+ ++++L ++E Q D G E + +PS+E + + G+
Sbjct: 538 VQRRPELEDSTLRYLQDLLAWVEENQHRVD--GAEWGVDLPSVEAQLGS-----HRGLHQ 590
Query: 697 ASLHLKAQVDQLTGRNEELRQELRESRKEAIN-----YSQQLAKANLKIDHLE------- 744
+ +A++++ +L R + ++ + Y++ L + ++ LE
Sbjct: 591 SIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVA 650
Query: 745 ---KETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNL 801
KE L + E V F D + ++ E L++ELE KEKK+K L
Sbjct: 651 AATKELMWLNEKEEEEVGFDWSDRNTNMT--------AKKESYSALMRELELKEKKIKEL 702
Query: 802 EDS-----LEDYNRKFAVIRHQQSL------------LYKEYLSEKETWKTESKTIKEEK 844
+++ ED+ + V Q +L + +L E + ++E +
Sbjct: 703 QNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAE 762
Query: 845 RKLEDQVQQDAIKVKEYN-------NLLNALQMDSDEMKKILAENSRKITVLQVNEKSLI 897
+L Q Q+A++ ++Y+ L L D+ + K+ L E ++ L K+++
Sbjct: 763 GQL--QKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVV 819
Query: 898 ----RQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVV 953
R + L + ++ E+ + + C+ +G Q + + + V
Sbjct: 820 QLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQP-SHWKVLSSSGSEAAV 878
Query: 954 DNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENI----SLKEQVES 1009
+ L + N++ E + L+ + + + H++ +++ SL+ V+
Sbjct: 879 PSVCFL--VPPPNQEAQEAVTR----LEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 932
Query: 1010 INK---------ELEITKEKLHTIE---QAWEQETKLGNESSMDKAKKSITNSDIVSISK 1057
I + E ++ LH++E QA+ ++++ + + + + S S
Sbjct: 933 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQ--DAGGFGPEDRLMAEREYGSCSH 990
Query: 1058 KITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLD------- 1110
L Q CQ+ L+ Q+E ET+ ++ LD
Sbjct: 991 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE----ACETRTVHRLRLPLDKEPAREC 1046
Query: 1111 AQKV-EQMLRDELADSVSKAVS--DADRQRILELE---------KNEMELKV-EVSKLRE 1157
AQ++ EQ + + K V+ A+ +++L L ++E+EL + ++ ++R
Sbjct: 1047 AQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRS 1106
Query: 1158 ISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATA 1217
+S I +++ ++ + E LR + + + +L SL+ A A
Sbjct: 1107 LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQA 1166
Query: 1218 LGK---LESITSKLQKMEAYNLRLEQKLDEKEQALYYAR--------------LEGRNRA 1260
+ +++ +L+ + RL+Q+ E++ + R + R
Sbjct: 1167 EAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ 1226
Query: 1261 KHLRQTIQSLRRQFSGALPLA---QQEKFSKTMIQLQ--NDKLKIMQEMKNSQQEHRNME 1315
+ L Q + LR A PL Q + + IQ D + ++++ Q +E
Sbjct: 1227 RELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIE 1286
Query: 1316 NKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELK---------LNRELV 1366
++E + ++ I+ +KD + +++ + ++E + K + +E V
Sbjct: 1287 RHGEKVEECQRFAKQYINAIKDYE--LQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1344
Query: 1367 KDKEEIKYLNNIISEYERTISSL------EEEIVQQNKFHEERQMAWDQREVDLERQLDI 1420
+ L + S+Y + IS EE + +Q + E ++A + E LE+Q +
Sbjct: 1345 DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA--EVEAALEKQRQL 1402
Query: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEK 1480
+ A ++ +E + + + + E A+ ++ I E + +S E +
Sbjct: 1403 AEAHAQAKAQAEREAKELQQRMQE---EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAE 1459
Query: 1481 LKEKESALRLAEQNILSRDKVINELRLRLPAT------AEREKLIAELGRKEMEPKSHHT 1534
++ K AE++ L ++ I +RL+L AT AE E +E E +
Sbjct: 1460 IQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQA 1519
Query: 1535 LKIAHQTIANMQARLNQKE----EVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLEL 1590
+ A + +Q +K E+ + + E ARE+QR + E L L
Sbjct: 1520 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE---------LRL 1570
Query: 1591 QADSSLNKFKQTAWDLMKQSPTPVPTNKHFI------RLAEMEQTVAEQDDSLSSLLVKL 1644
QA+ + + +Q + +Q + T + + A + A+ + SL V +
Sbjct: 1571 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1630
Query: 1645 KKVSQDLER--QREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDL--KYLLDQSQKE 1700
++ ++ ER Q++ + +E +L+ + +E +++ + E++ + L Q++ E
Sbjct: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690
Query: 1701 SQCLKSELQAQKEANSRAPTTTMRNLVER-LKSQLALKE---KQQKALSRALLELRAEMT 1756
Q ++E +A++ + R L E+ L+ Q L E +Q+ A + L+ LRAE
Sbjct: 1691 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1750
Query: 1757 AAAEERII----SATSQKEAHLNVQ--QIVDRHTRELKTQVEDLNENLLKLKEALKT--- 1807
++R + A Q+EA Q Q ++ +++ ++E L + + +E ++
Sbjct: 1751 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1810
Query: 1808 -SKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPL 1866
SK R + +L E + + + R+++ +++ + + +R+ +
Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA------- 1863
Query: 1867 TDNKQSLIEELQRKVKKLENQL-EGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIE-- 1923
K + I E R + E L E + E L+ + E A + E+ + +A IE
Sbjct: 1864 --EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1921
Query: 1924 ------GIRNKLKEKEGEVFTLTKQ-------LNTLKDLFAKADKEKLTLQRKLKTTGMT 1970
++L+ ++G V +Q + LK F KA K L+ +L
Sbjct: 1922 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1981
Query: 1971 VDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLH 2030
+ L + + ELE ++R L E + A + + + E+ + R + L
Sbjct: 1982 AEDTL---RSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQR--KAALE 2036
Query: 2031 ALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQ-ANKDLPRL 2089
+E+ +K E+ +R ++ L+L+ E + + Q E+ A+ +
Sbjct: 2037 EVERLKAKVE---------EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2087
Query: 2090 KNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENE 2149
K Q E+ + L++E++ + + G + R+ + E +VQ E E
Sbjct: 2088 KEQ-----ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE------------ARVQAERE 2130
Query: 2150 QLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERL 2209
+ + +E++ +E + +A+ + L + + + + + + +
Sbjct: 2131 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2190
Query: 2210 RKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETG--KRLQFAESRGPQLEGADSKSWK 2267
E++K AE+ K +E + +QLEET K L E + + E ++ +
Sbjct: 2191 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2250
Query: 2268 SIVVTRMYETK-----LKELETDIAKKNQSITDLKQLVKEATER--EQKVNKYNEDLEQQ 2320
S V ++ + L +L+ I +N+++ L+ K+ T+R +++ K + E+
Sbjct: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALI-LRD--KDNTQRFLQEEAEKMKQVAEEA 2307
Query: 2321 IKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQ 2380
++ E A Q + +L R ++ KEK + + EA + ++ AE +
Sbjct: 2308 ARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ--EATRLKAEAELLQQQKEL 2365
Query: 2381 LKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFE---EIEDLKYNYKEEVKK 2437
+E+ + L+ + Q L EE + ++ LE E E E LK E +
Sbjct: 2366 AQEQARRLQED---KEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2422
Query: 2438 NILLEE---KVKKLSEQLGVELTSPVAASEE 2465
EE + +K +E++G +L A++E
Sbjct: 2423 QARAEEDAQRFRKQAEEIGEKLHRTELATQE 2453
Score = 130 bits (327), Expect = 2e-29
Identities = 247/1349 (18%), Positives = 554/1349 (41%), Gaps = 139/1349 (10%)
Query: 39 ELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENEL 98
E EKQ + ++ + +A+E++ ++E EE A Q K + + +L
Sbjct: 1393 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452
Query: 99 EMA----------QQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQL 148
+ Q A R + EI + QLE +R+ E EL+ + E+
Sbjct: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1512
Query: 149 ALRNEEAENENSKLRR----ENKRLKKKNEQLCQDI-------IDYQKQIDSQKETLLSR 197
+ +A+ E +LRR E++R ++ +L + + Q+ + + +E L
Sbjct: 1513 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1572
Query: 198 RGEDSDYRSQLSKKNYELIQYLDEIQTLTEAN-EKIEVQNQEMRKNLEESVQE----MEK 252
+ R ++ ++ L+ Q EA + E LE S+QE + +
Sbjct: 1573 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ 1632
Query: 253 MTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDL-LKSKNEEDDPIMVAVNAKVE 311
+ +E R + + ++ ++E + +QL+ E L L+++ + A+ +
Sbjct: 1633 LREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1692
Query: 312 EWKLILSSK-----DDEIIEYQQMLHNLREKLKN------AQLDADKSNVMALQQGIQER 360
+ + ++ +++ + +++ EK + Q A + ++ L+ ++
Sbjct: 1693 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1752
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQR---------------NKGASTLSQQT 405
+ Q ++L E++ + +E T ++L+ EL + + + + S+++
Sbjct: 1753 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1812
Query: 406 HMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEI 465
++++ +E +EA R LAE R++ +A ++ + E + A+ E
Sbjct: 1813 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1872
Query: 466 KNCKNQIKIRDREIEILTKEINKL--ELKISDFLDENEALRERVGLEPKTMIDLTEFRNS 523
K + +I +E E + + +L + E +A + + +E + L + R +
Sbjct: 1873 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKA 1928
Query: 524 KHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSG---LTTEDLNLT 580
+ ++ + + L++ +EEE L LK + A + + G ED +
Sbjct: 1929 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988
Query: 581 ENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKEL 640
+ ++ + +R+L + EA+ + ++ + E + R R + +LK
Sbjct: 1989 KEQAELEAARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKAK 2044
Query: 641 VEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLH 700
VEE ++L E ++ ++ +++Q E + E +A + E +L
Sbjct: 2045 VEEARRLRERAEQ--ESARQLQ-----LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2097
Query: 701 LKAQV-DQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVV 759
+ V DQL G E R+ E+ + + ++ A++ +++ E+ L+QS
Sbjct: 2098 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER----LKQSAEEQAQ 2153
Query: 760 FKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQ 819
+ A ++A + + E + E + K D+ + ++KFA +Q
Sbjct: 2154 AR------AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2207
Query: 820 SLLYKEYLS----EKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEM 875
++ L+ + E + + EE ++L+ + + A + + L ++++ +E+
Sbjct: 2208 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEEL 2267
Query: 876 KKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEA----EVCEK 931
K+ A + L + +K +++ E E+ + E + + + EA ++ E+
Sbjct: 2268 SKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2326
Query: 932 IGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTS 991
QR + K +Q V + + +E EL +Q EL + LQ+D + +
Sbjct: 2327 DLAQQRALAEKMLK-EKMQAVQEATRLKAEAELLQQQ-KELAQEQARRLQEDKEQMAQQL 2384
Query: 992 NLEHLECENISLKEQVESINKELEITKEKLHTIE----QAWEQETKLGNESSMDKAKKSI 1047
E + E+ + E + KL E QA +E ++ + +
Sbjct: 2385 AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKL 2444
Query: 1048 TNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFEL--ETKFAELT 1105
+++ + +K+T+++ E+ +RQ+++H E LR ++ ++E +L E K +L
Sbjct: 2445 HRTELAT-QEKVTLVQTLEI-QRQQSDHDA---ERLREAIAELEREKEKLQQEAKLLQLK 2499
Query: 1106 KINLDAQKVEQMLRDELA---DSVSKAVSDADRQRILELEKNEME--LKVEVSKLREISD 1160
+ + EQ+L++ A +S+ S R+R +E EK ++E + EV+K +++ +
Sbjct: 2500 SEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2559
Query: 1161 IARRQVEILNAQQQSRDKEVESLR----------------MQLLDYQAQSDEKSLIAKLH 1204
+RQ + + ++Q +E R +Q L+ Q + E+ L +
Sbjct: 2560 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQ 2619
Query: 1205 QHNVSLQLSE---ATALGKLESITSKLQKMEAYNLRLEQKLDEKEQAL--YYARLEGRNR 1259
+ LQL E AL E +T A + + L AL A E +
Sbjct: 2620 RLREQLQLLEEQHRAALAHSEEVT-------ASQVAATKTLPNGRDALDGPAAEAEPEHS 2672
Query: 1260 AKHLRQTIQSLRRQFSGALPLAQQEKFSK 1288
LR+ + + R Q +G L + ++ ++
Sbjct: 2673 FDGLRRKVSAQRLQEAGILSAEELQRLAQ 2701
Score = 53.9 bits (128), Expect = 2e-06
Identities = 233/1241 (18%), Positives = 475/1241 (38%), Gaps = 202/1241 (16%)
Query: 1353 ELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEE--RQMAWD-- 1408
+L + L+ ++L + E ++ L I+++ + EE++ Q + + R +A
Sbjct: 399 KLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKV 458
Query: 1409 -QREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRII 1467
QR ++ER LD D + N Q ++ + +L L I+ +
Sbjct: 459 PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 518
Query: 1468 LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLI------AE 1521
L+ + + +S R E D + L+ L E + + +
Sbjct: 519 LKAGVAAPATQVAQVTLQSVQRRPELE----DSTLRYLQDLLAWVEENQHRVDGAEWGVD 574
Query: 1522 LGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDL 1581
L E + SH L HQ+I +A++ E+AR ++ ++
Sbjct: 575 LPSVEAQLGSHRGL---HQSIEEFRAKI--------------ERARSDEGQLSPATRGAY 617
Query: 1582 HILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLL 1641
RL+LQ LN K L K + L E E+ D S +
Sbjct: 618 RDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTN 677
Query: 1642 VKLKKVSQD-LERQREITELKVKEFEN--------------------------------- 1667
+ KK S L R+ E+ E K+KE +N
Sbjct: 678 MTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQL 737
Query: 1668 ---IKLQLQENHE-----DEVKKVKAEVEDL------KYLLDQSQKESQC--LKSELQAQ 1711
I+ L+EN +V++ + +++ L KY D+S ++ L + Q +
Sbjct: 738 CCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDE 797
Query: 1712 KEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRA-----------------E 1754
KE + + L +R K+ + LK + R L L A +
Sbjct: 798 KEQLNEYKGH-LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQ 856
Query: 1755 MTAAAEE---RIISATSQKEAHLNVQQIV---DRHTRELKTQVEDLNENLLKLKEALKT- 1807
+ A+ +++S++ + A +V +V ++ +E T++E ++ L+ L L
Sbjct: 857 LVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVD 916
Query: 1808 --------SKNRENSL----------TDNLNDLNNELQKKQKAYNKILREKEEI------ 1843
S R+ L T + L + Y LR+ ++
Sbjct: 917 MKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPE 976
Query: 1844 -----DQENDELKRQIKRLTSGL-QGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDL 1897
++E ++L L QG Q I EL+ +LE V + L
Sbjct: 977 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1036
Query: 1898 KPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEK 1957
P+ ++ A+E R E +K QA++EG+ + E +++ L + A
Sbjct: 1037 -PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEA----EKVLALPEPSPAAP--- 1088
Query: 1958 LTLQRKLKTTGMTVDQVLGIRALESEK-ELEELKKRNLDLENDILYMRAHQALPRDSVVE 2016
TL+ +L+ T ++QV + A+ EK + L R ++L RAH+ +++
Sbjct: 1089 -TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVL--RAHEEQLKEAQAV 1145
Query: 2017 DLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELK 2076
L L+ +L+K ++ +P+ + D + QE+ + +L + E
Sbjct: 1146 PATLPE--LEATKASLKKLRAQAEAQQPTFDALR--DELRGAQEVGE---RLQQRHGERD 1198
Query: 2077 FQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRS-GKTIPELEKTIG 2135
++E+ + + +L + + + + ++E ++ R+L + R S G + + +
Sbjct: 1199 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1258
Query: 2136 LMKKV-VEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLG--HQLSMHY 2192
++ + + Q EQL++ +L IE+ EK++ K ++ +
Sbjct: 1259 QIQAMPLADSQAVREQLRQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQL 1313
Query: 2193 ESKTKGTEKIIAENERLRKELKKETDAAE--KLRIAKNNLEILNEKMTVQLEETGKRLQF 2250
+ E + + ++ + + E+ E LR + L L + + ET +R++
Sbjct: 1314 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1373
Query: 2251 AESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKV 2310
E Q + + +L E+E + K+ Q + + K ERE K
Sbjct: 1374 EERLAEQQRAEERE-------------RLAEVEAALEKQRQ-LAEAHAQAKAQAEREAKE 1419
Query: 2311 NKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSG 2370
+ E+ ++ + + + ++ ++ ELQ LR ++ +AE+ Q +A + ++
Sbjct: 1420 LQQRMQ-EEVVRREEAAVDAQQQKRSIQEELQQLRQSS------EAEI--QAKARQAEAA 1470
Query: 2371 AESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYN 2430
S + +++E+I+ + QL+ ++ ++ + E++ L+ E E E K
Sbjct: 1471 ERSRL----RIEEEIRVVRLQLEATERQRGGAEGELQALRARAE--------EAEAQKRQ 1518
Query: 2431 YKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEE 2471
+EE ++ + + Q VEL S V A E E++
Sbjct: 1519 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQ 1559
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 166 bits (420), Expect = 3e-40
Identities = 256/1225 (20%), Positives = 540/1225 (44%), Gaps = 132/1225 (10%)
Query: 226 TEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQV 285
TE+ + + V+ + + + QE+E+ T++ K + Q + + +L++EN +
Sbjct: 243 TESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN------M 296
Query: 286 QELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLR-EKLKNAQLD 344
L+D ++ D+ ++A + E + + + E+ Y++ LH++ K + +L
Sbjct: 297 NLLSDARSARMYRDE-----LDA-LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350
Query: 345 ADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNE--LQRNKGASTLS 402
D ++ + ++++ + ++++ + KE + + D++ E + R K +
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410
Query: 403 QQTHMKIQSTLDI-----LKEKTKEAERTAELAEADAREKDKELVE-ALKRLKDYESGVY 456
+ +++ + L + ++ RT+EL+EA + E+ E RL E
Sbjct: 411 ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQ 470
Query: 457 GLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMID 516
L V E++ + ++ +I + KE +L K+ + ENE ++E+ L+
Sbjct: 471 SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE--ILENEIVQEKQSLQ------ 522
Query: 517 LTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTED 576
N ++L + + + Q L K IE+L E + +++I+ + QE + T +
Sbjct: 523 -----NCQNLSKDLMKEKAQ-LEKTIETLRE---NSERQIKILEQENEHLNQTVSSLRQR 573
Query: 577 LNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNK 636
++ D E K+ S+K S SK EF R++ ++ + + +N+
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633
Query: 637 LKELVEENKQLEEGMK------EILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKN 690
L L +EN+ L++ + E ++A+++ + + + + + S + L +ES
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 691 AEG--IFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETS 748
E + + +L L+ V+ L + ++ Q L+ KE + +QL K LE +
Sbjct: 694 KENSQLDEENLELRRNVESLKCASMKMAQ-LQLENKELESEKEQLKKG------LELLKA 746
Query: 749 LLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKL-KNLEDSLED 807
+++E V ++G+D+ + + N + + L LQ+LE + + L KNLE+
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 808 YNRKFAVIRHQQSLLYKEYLSEKETWKTE--SKTIKEEKRKLEDQVQQDAIKVKEYNNLL 865
R + + +SL E+ET + E K +++E ++L Q + ++E N +
Sbjct: 807 SKRLEQLEKENKSL-------EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
Query: 866 NALQMDSDEMKK---ILAENSRKITVLQVNEKSLIRQYT----TLVELERQLRKENEK-- 916
L+ ++ + K I E+ ++ L+ K L+++ T TLV L L E K
Sbjct: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQ 919
Query: 917 QKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKY 976
Q N L EKIG + ++ ++ D+ L E +L E T K
Sbjct: 920 QMNNDLEKLTHELEKIGLNKE-------RLLHDEQSTDDRYKLLESKL------ESTLK- 965
Query: 977 RDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGN 1036
+ + K+ + + LE N L+++++++ K E K++ E+ + +
Sbjct: 966 KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR-QDEERMVQSSPPISG 1024
Query: 1037 ESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFE 1096
E + + + T +++ + K ++E++ N +AE + L+T LKQ+E +N
Sbjct: 1025 EDNKWERESQETTRELLKV--KDRLIEVERNNATLQAEK-----QALKTQLKQLETQNNN 1077
Query: 1097 LETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLR 1156
L+ + L + + Q+ L+ + ++ + + + L +L ++ S L
Sbjct: 1078 LQAQILALQRQTVSLQEQNTTLQTQ--NAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1135
Query: 1157 EISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAK---LHQHNVSLQLS 1213
++ ++ E L + S K+ E +++LL + S+ +SLI+K L + +L++
Sbjct: 1136 NENESVIKEREDLKSLYDSLIKDHE--KLELLHERQASEYESLISKHGTLKSAHKNLEVE 1193
Query: 1214 E----------ATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHL 1263
G+LE + K+ K+E + LE K + + A Y +L G N L
Sbjct: 1194 HRDLEDRYNQLLKQKGQLEDL-EKMLKVEQEKMLLENK-NHETVAAEYKKLCGEN--DRL 1249
Query: 1264 RQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMEL 1323
T L ++ L K K++ L N KL E + E ++ + ++++
Sbjct: 1250 NHTYSQLLKETE---VLQTDHKNLKSL--LNNSKL----EQTRLEAEFSKLKEQYQQLDI 1300
Query: 1324 KLKGLEELISTLKDTKGAQKVINWHM--KIEELRLQELKLNRELVKDK-----EEIKYLN 1376
L L KG + N H+ +I+ L LQ L + ++ K E+ +Y++
Sbjct: 1301 TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID 1360
Query: 1377 NIISEYERTISSLEEEIVQQNKFHE 1401
++E R LEE+I+ Q KF++
Sbjct: 1361 K-LNELRRQKEKLEEKIMDQYKFYD 1384
Score = 156 bits (394), Expect = 3e-37
Identities = 270/1195 (22%), Positives = 510/1195 (42%), Gaps = 211/1195 (17%)
Query: 1370 EEIKYLNNIISEYERTISSLEE--EIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNE 1427
EE+K L ++ EE E +Q F + +A +EV Q ++FD Q E
Sbjct: 119 EEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVT-HNQENVFDLQWME 177
Query: 1428 ILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESA 1487
+ + +Q+ E PL + + L+++ ++E+ + E+
Sbjct: 178 VTDMSQEDIE----------PLLKNMALHLKRL----------------IDERDEHSETI 211
Query: 1488 LRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQA 1547
+ L+E+ + L A++ + G K E + H ++++A + +A
Sbjct: 212 IELSEER--------DGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELA-----DAKA 258
Query: 1548 RLNQ-KEEVLKKYQRLLEKARE-EQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWD 1605
++ + ++E+ +K ++LL+ +E EQ EI K + + L +D+ + + D
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKR-----LQQENMNLLSDARSARMYRDELD 313
Query: 1606 LMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVK-- 1663
+++ +R+ ++E V+ + L + +V + E + + E K
Sbjct: 314 ALREKA---------VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
Query: 1664 -EFENIKLQLQENHEDEVK--KVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPT 1720
+ E + + + HE E + ++KA++ D++ D +K+ + L E + A ++
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
Query: 1721 TTMRN--LVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQ-KEAHLNVQ 1777
++ +E++ L E QK+L + EL + E S T +E V
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 1778 QIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKI- 1836
+ ++ LK + E N+ L K E L+ +E N +L+ +L K++ K
Sbjct: 485 SVEGNASKILKMEKE--NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542
Query: 1837 --LREKEE-----IDQENDELK------RQIKRLTSGLQGKPL-------------TDNK 1870
LRE E ++QEN+ L RQ ++++ + K + T +K
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
Query: 1871 QSLIEELQRKVKK--------------LENQLEGKVEEVDLKPMKEKNAKEELIRWEEGK 1916
S IE +R++KK LEN+L +E +L K N K + E +
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 1917 KWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQR---KLKTTGMTVDQ 1973
+ +++E KLK+ LT QL +L+ ++ D+E L L+R LK M + Q
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
Query: 1974 V-LGIRALESEKE-----LEELKK------------RNLDLENDILYMRAHQALPR---- 2011
+ L + LESEKE LE LK + LD+EN L + +
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 2012 DSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSE 2071
+S ++DL ++N+ LQ+ L L+ IS +R ++L+KEN L E
Sbjct: 783 ESELQDLEMENQTLQKNLEELK------------ISS-------KRLEQLEKENKSLEQE 823
Query: 2072 NIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELE 2131
+L+ KD +L+ + + L++ E E K+G++ ++ L
Sbjct: 824 TSQLE-------KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT------LS 870
Query: 2132 KTIGLMKKV---VEKVQRENEQLKKASGI-----------LTSEKMANIEQEN--EKLKA 2175
K IG+ K+ ++++++EN++L K + I L SEK+ + N EKL
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 2176 ELEKLKAHLGHQLSMHYESKTKGTEKIIAE--NERLRK--ELKKETDAAEKLRIAKN--- 2228
ELEK+ L + +H E T K++ L+K E+K+E AA + R+ ++
Sbjct: 931 ELEKI--GLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 988
Query: 2229 NLEILNEKMTVQLEETGKRLQFAESR----GPQLEGADSKSWKSIVVTRMYETKLKELET 2284
N ++ E TV+ + + E R P + G D+K + T K+K+
Sbjct: 989 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048
Query: 2285 DIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVL 2344
++ + N ++ KQ +K T+ +Q + N Q + + + E L+ + L
Sbjct: 1049 EVERNNATLQAEKQALK--TQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKL 1106
Query: 2345 RLANHQLDKEKAELIHQ-----IEANKDQSGAESTIPDADQLK----EKIKDLETQLKMS 2395
++ N L+ + L++Q I+ + ++ ES I + + LK IKD E K+
Sbjct: 1107 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE---KLE 1163
Query: 2396 DLEKQHLKEEIKKLKKE--LENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKL 2448
L ++ E + K L++ + E DL+ Y + +K+ LE+ K L
Sbjct: 1164 LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML 1218
Score = 150 bits (380), Expect = 1e-35
Identities = 257/1233 (20%), Positives = 533/1233 (43%), Gaps = 148/1233 (12%)
Query: 116 EICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQ 175
E+ + ++ + +ELE+ ++L K+ EQ+ + + + EN L + + +
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARM---- 307
Query: 176 LCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQ 235
Y+ ++D+ +E + +S+ S+ ++ +++ Y ++ L E N+ +
Sbjct: 308 -------YRDELDALREKAVRVDKLESEV-SRYKERLHDIEFYKARVEELKEDNQVL--- 356
Query: 236 NQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSK 295
E + LE+ ++ +D+ + ++ Q + ++ E D + +++EL
Sbjct: 357 -LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM------ 409
Query: 296 NEEDDPIMVAVNAKVEE-----WKLILSSKDDEIIEYQQ--MLHNLREKLKNAQLDADKS 348
EE+ + +A ++E W+L S+ E+ E Q + H + E + L +
Sbjct: 410 -EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
Query: 349 NVMALQQGIQERDSQIKML---TEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQT 405
N +L + ++E + + + ++ + KE ++ + +E L+NE+ + K + Q
Sbjct: 469 N-QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 406 HMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLE--DAVV 463
+ D++KEK + E+T E ++ + K L + + L S + A
Sbjct: 528 ------SKDLMKEKA-QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 464 EIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNS 523
+K+ + + KI I+ + +++K+E + E E +E+ + +L
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
Query: 524 KHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMA-----------QERGKRSATSGL 572
L Q++ +I ++IE+LE+E +L+++ R++ Q S L
Sbjct: 641 NELLQKKI-TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 699
Query: 573 TTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAK 632
E+L L N+ + + + K+ L L+N E +S+ E L + L + +++ +
Sbjct: 700 DEENLELRRNV-ESLKCASMKMAQLQLEN-KELESEKEQLKKGLELLKASFKKTERLEVS 757
Query: 633 FQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAE 692
+Q E K LE K+I Q E+Q D ++ E + +LE L I SK E
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQ-DLEM---ENQTLQKNLEEL--KISSKRLE 811
Query: 693 GIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQ 752
+ + L+ + QL ++L +E + R++A L + N+KI +LEKE L +
Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 753 SEG----SNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDY 808
G S V K ++ + A+I + L+ L ++L +++ K + + + LE
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATI---DIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
Query: 809 NRKFAVI-RHQQSLLYKEYLSEKETWKTESK---TIKEEKRKLEDQVQQDAIKVKEYNNL 864
+ I +++ LL+ E ++ ESK T+K+ E+++ +++E N
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 988
Query: 865 LNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSM 924
L+ + +KK N + Q +E+ +++ + + + +E+++ ELL +
Sbjct: 989 NQQLRQELKTVKK----NYEALKQRQ-DEERMVQSSPPISGEDNKWERESQETTRELLKV 1043
Query: 925 EAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI-LQKD 983
+ + E E + A ++ + + E + N Q L + + + LQ+
Sbjct: 1044 KDRLIE--------VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1095
Query: 984 NMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKA 1043
N +Q T N + L+ EN +L Q S+ ++ Q Q++ L NE+
Sbjct: 1096 NTTLQ-TQNAK-LQVENSTLNSQSTSL----------MNQNAQLLIQQSSLENENESVIK 1143
Query: 1044 KKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEH--LRTSLKQMEERNFELETKF 1101
++ S S+ K LE+ L+ERQ +E+ + +H L+++ K +E + +LE ++
Sbjct: 1144 EREDLKSLYDSLIKDHEKLEL--LHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRY 1201
Query: 1102 AELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDI 1161
+L K + +E+ML+ +++++L KN + E KL +D
Sbjct: 1202 NQLLKQKGQLEDLEKMLK-------------VEQEKMLLENKNHETVAAEYKKLCGEND- 1247
Query: 1162 ARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKL 1221
LN KE E L Q+D K+L + L+ + EA +
Sbjct: 1248 ------RLNHTYSQLLKETEVL---------QTDHKNLKSLLNNSKLEQTRLEA----EF 1288
Query: 1222 ESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLA 1281
+ + Q+++ + +L + + Q LE NR HL IQ+L Q L
Sbjct: 1289 SKLKEQYQQLDITSTKLNNQCELLSQ--LKGNLEEENR--HLLDQIQTLMLQ---NRTLL 1341
Query: 1282 QQEKFSKTMIQLQN----DKLKIMQEMKNSQQE 1310
+Q SK + ++ DKL ++ K +E
Sbjct: 1342 EQNMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1374
Score = 150 bits (379), Expect = 2e-35
Identities = 269/1335 (20%), Positives = 554/1335 (41%), Gaps = 183/1335 (13%)
Query: 260 MKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSS 319
++ + H +NV D LQ E+TD+ E+ +P++ + + K ++
Sbjct: 160 IQEVTHNQENVFD----------LQWMEVTDM---SQEDIEPLLKNMALHL---KRLIDE 203
Query: 320 KDD------EIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQ 373
+D+ E+ E + LH L +AQ M + Q ++ ++ +
Sbjct: 204 RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG-MKRTESRQHLSVELADAKAKIRR 262
Query: 374 YTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQST----------LDILKEKT--- 420
+E+E+ T + D K EL++ + QQ +M + S LD L+EK
Sbjct: 263 LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV 322
Query: 421 ----------KEAERTAELAEA---DAREKDKELVEALKRLKDYESGVYGLEDAVVEIKN 467
KE E +A + +E ++ L+E L+D G D + E++
Sbjct: 323 DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEK 382
Query: 468 CKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHL- 526
Q+K + ++E+ E + KI + ++EN L M S HL
Sbjct: 383 ENLQLKAKLHDMEM---ERDMDRKKIEELMEENMTLE---------MAQKQSMDESLHLG 430
Query: 527 -KQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQ 585
+ +Q +++ +SL E +L R + E +S T T E+L T + +
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSS-RLLKLEMENQSLTK--TVEELRTTVDSVE 487
Query: 586 GDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENK 645
G+ K++ K K E L E++++++ L+ QN K+L++E
Sbjct: 488 GNASKILKME----KENQRLSKKVEILENEIVQEKQSLQNC-------QNLSKDLMKEKA 536
Query: 646 QLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQV 705
QLE+ ++ + + + K + + + + SL + + I + L +
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596
Query: 706 DQLTGRNEELRQELRESRKEAINYSQQLAKA---NLKIDHLEKETSLLRQSEGSNVVFKG 762
+ + + ++ E R+ +KE +Y ++ +A ++ HLEKE LL++
Sbjct: 597 KETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK--------- 647
Query: 763 IDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLL 822
++ I + E L ELE + +KLK DS ++ + + + S L
Sbjct: 648 --------ITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 699
Query: 823 YKEYLSEKETWKT-------------ESKTIKEEKRKLEDQVQQDAIKVKEYNNL---LN 866
+E L + ++ E+K ++ EK +L+ ++ K+ L
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759
Query: 867 ALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVE-LE---------RQLRKENEK 916
L +++ ++K L +++KI L+ + L + TL + LE QL KEN+
Sbjct: 760 GLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Query: 917 QKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQ-------Y 969
+ E +E + + +R ++ A K L+ +N+V + LE NK Y
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE---ENNVKIGNLEKENKTLSKEIGIY 876
Query: 970 NELTAKYRDILQKDNMLVQRTS----NLEHLECENISLKEQVESINKELEITKEKLHTIE 1025
E + +++ +++ LV+R + L L + +S K + + +N +LE +L I
Sbjct: 877 KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI- 935
Query: 1026 QAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRT 1085
+E L +E S D K + + ++ K + + E K R E + LR
Sbjct: 936 -GLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQ 994
Query: 1086 SLKQMEERNFELETKFAE--LTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEK 1143
LK +++ L+ + E + + + + E ++ + + D R++E+E+
Sbjct: 995 ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKD--RLIEVER 1052
Query: 1144 NEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKL 1203
N L+ E L + Q++ L Q + ++ +L+ Q + Q Q+ L
Sbjct: 1053 NNATLQAEKQAL-------KTQLKQLETQNNNLQAQILALQRQTVSLQEQN------TTL 1099
Query: 1204 HQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHL 1263
N LQ+ +T L S ++ L A L + L+ + +++ R + L
Sbjct: 1100 QTQNAKLQVENST----LNSQSTSLMNQNAQLLIQQSSLENENESVIKER-------EDL 1148
Query: 1264 RQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMEL 1323
+ SL + L +++ + ++ LK KN + EHR++E++ ++ L
Sbjct: 1149 KSLYDSLIKDHEKLELLHERQASEYESLISKHGTLK--SAHKNLEVEHRDLEDRYNQL-L 1205
Query: 1324 KLKG-LEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEY 1382
K KG LE+L LK + +K++ + E + + KL E D+ Y + ++ E
Sbjct: 1206 KQKGQLEDLEKMLKVEQ--EKMLLENKNHETVAAEYKKLCGE--NDRLNHTY-SQLLKET 1260
Query: 1383 E--RTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATG 1440
E +T + ++ +K + R A + + +QLDI + N N + + G
Sbjct: 1261 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN---NQCELLSQLKG 1317
Query: 1441 SIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDK 1500
++ + + L +Q++ + + + + +E++ + + +K + LR ++ + +K
Sbjct: 1318 NLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKL--EEK 1375
Query: 1501 VINELRLRLPATAER 1515
++++ + P+ R
Sbjct: 1376 IMDQYKFYDPSPPRR 1390
Score = 149 bits (376), Expect = 3e-35
Identities = 259/1164 (22%), Positives = 493/1164 (42%), Gaps = 207/1164 (17%)
Query: 22 EELADNLLI---SLSKVEVNELKSEKQENV--------IHLFRITQSLMKMKAQEVELAL 70
EE + LL L ++E+ ELK +QEN+ ++R ++ KA V+
Sbjct: 268 EEKTEQLLDCKQELEQMEI-ELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLE 326
Query: 71 EEVE------------KAGEEQAKFENQ--LKTKVMKLENELEMAQQSAGGRDTRFLRNE 116
EV KA E+ K +NQ L+TK M LE++LE TR ++
Sbjct: 327 SEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM-LEDQLE---------GTRARSDK 376
Query: 117 ICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQL 176
+ +LEK+ Q +L DME E + ++K E+L N E + E+ L + EQ+
Sbjct: 377 LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQI 436
Query: 177 CQ--DIIDY-QKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANE--- 230
+ ++ + QK + + L S R +L +N L + ++E++T ++ E
Sbjct: 437 SRTSELSEAPQKSLGHEVNELTSSR------LLKLEMENQSLTKTVEELRTTVDSVEGNA 490
Query: 231 ----KIEVQNQEMRKNLE----------ESVQEMEKMTDEYNRMKAIVHQT--------D 268
K+E +NQ + K +E +S+Q + ++ + + KA + +T +
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550
Query: 269 NVIDQLKKENDHYQLQVQELTD--------LLKSKNEEDDPIMVAVN------AKVEEWK 314
I L++EN+H V L +K +E+ + ++ +K+E K
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEK 610
Query: 315 LIL-------SSKDDEIIEYQQMLHN-------LREKLKNAQLDADKSNVMALQQGIQER 360
+ K + E + LH+ L++K+ N ++ +K + AL+Q E
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEK--IEALEQENSEL 668
Query: 361 DSQIKMLTEQVEQY------TKEMEKNTCIIEDLKNELQRN----KGASTLSQQTHM--- 407
+ + + L + ++ + + +EK +++ EL+RN K AS Q +
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENK 728
Query: 408 -------KIQSTLDILK---EKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYG 457
+++ L++LK +KT+ E + + + + + K L + K+++ ES +
Sbjct: 729 ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD 788
Query: 458 LEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKIS-------DFLDENEALRERVGLE 510
LE ++ ++KI + +E L KE LE + S EN+ LR++ ++
Sbjct: 789 LEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIK 848
Query: 511 PKTM------IDLTEFRNSKHLKQQQYRAENQILLKEIE------------------SLE 546
T+ I E N K+ E+ + LKE+E +L
Sbjct: 849 DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR 908
Query: 547 EERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQ 606
E+ + K K +QM + K T L LN E + ++ ++ + LL K S +
Sbjct: 909 EDLVSEKLKTQQMNNDLEK--LTHELEKIGLN-KERLLHDEQSTDDRYKLLESKLESTLK 965
Query: 607 SKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPD 666
E ++ E LE S + +L++ ++ K+ E +K+ + +Q P
Sbjct: 966 KSLEIKEEKIAALEARLEES----TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1021
Query: 667 VKGGE----------TSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELR 716
+ G + T ++ +RL+ +E NA + LK Q+ QL +N L+
Sbjct: 1022 ISGEDNKWERESQETTRELLKVKDRLIE-VERNNAT-LQAEKQALKTQLKQLETQNNNLQ 1079
Query: 717 QELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASI 776
++ +++ ++ +Q + L+ E S L S S+
Sbjct: 1080 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS-------------------QSTSL 1120
Query: 777 INSQNEYLIHLLQELENKEKK-------LKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSE 829
+N QN L+ LEN+ + LK+L DSL + K ++ +Q+ Y+ +S+
Sbjct: 1121 MN-QNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISK 1179
Query: 830 KETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVL 889
T K+ K ++ E R LED+ Q +K+ L + +M E +K+L EN TV
Sbjct: 1180 HGTLKSAHKNLEVEHRDLEDRYNQ---LLKQKGQLEDLEKMLKVEQEKMLLENKNHETV- 1235
Query: 890 QVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEV-CEKIGCLQRFKEMAIFKIAA 948
K L + L QL KE E + + ++++ + K+ + E + K
Sbjct: 1236 AAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY 1295
Query: 949 LQKVVDNSVSLSELELANKQYNELTAKYRDILQKDN--MLVQRTSNLEHLECENISLKEQ 1006
Q + ++ ++ EL ++ L + R +L + ML RT +++E +++ EQ
Sbjct: 1296 QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQ 1355
Query: 1007 VESINKELEITKEKLHTIEQAWEQ 1030
+ I+K E+ ++K E+ +Q
Sbjct: 1356 RQYIDKLNELRRQKEKLEEKIMDQ 1379
Score = 142 bits (359), Expect = 3e-33
Identities = 313/1502 (20%), Positives = 632/1502 (42%), Gaps = 260/1502 (17%)
Query: 947 AALQKVVDNSVSLSELELANKQYNELTAKYRDILQKD--NMLVQRTSNLEHLECENISLK 1004
A +Q+V N ++ +L Q+ E+T D+ Q+D +L +L+ L E
Sbjct: 158 AHIQEVTHNQENVFDL-----QWMEVT----DMSQEDIEPLLKNMALHLKRLIDERDEHS 208
Query: 1005 EQVESINKELEITKEKLHTIEQAWEQ-ETKLGNESSMDKAKKSITNSDIVSISKKITMLE 1063
E + +++E ++ LH + A ++ G+ + + ++ KI L
Sbjct: 209 ETIIELSEE----RDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLR 264
Query: 1064 MKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELA 1123
+ + ++ C++ E + LK++++ N L L + +M RDEL
Sbjct: 265 QELEEKTEQLLDCKQELEQMEIELKRLQQENMNL-----------LSDARSARMYRDEL- 312
Query: 1124 DSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESL 1183
DA R++ + ++K E E+ +L +I + + +VE L Q + L
Sbjct: 313 --------DALREKAVRVDKLESEVSRYKERLHDI-EFYKARVEELKEDNQVLLETKTML 363
Query: 1184 RMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLD 1243
QL +A+SD+ + +L + N+ L+ +KL ME +K++
Sbjct: 364 EDQLEGTRARSDK---LHELEKENLQLK--------------AKLHDMEMERDMDRKKIE 406
Query: 1244 E---KEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKI 1300
E + L A+ + + + HL ++ + R + L A Q+ + +L + +L
Sbjct: 407 ELMEENMTLEMAQKQSMDESLHLGWELEQISR--TSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 1301 MQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKG-AQKVINWHMKIEELRLQEL 1359
++ MEN++L K +EEL +T+ +G A K++ + + L +
Sbjct: 465 LE-----------MENQSLT-----KTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 1360 KLNRELVKDKEEIKYLNNII-------SEYERTISSLEEEIVQQNKFHEERQMAWDQREV 1412
L E+V++K+ ++ N+ ++ E+TI +L E +Q K E+ +Q
Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
Query: 1413 DLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRA 1472
L ++ I + + + K SI + S L +++E R+IK+ + E
Sbjct: 569 SLRQRSQISAEARVKDIEKENKILHE--SIKETSSKL-SKIEFEKRQIKKELEHYKEKGE 625
Query: 1473 TCKSLE----------EKLKEKESALRLAEQNILSRDKVINELRL---RLPATAER---- 1515
+ LE E L++K + L++ + I + ++ +EL +L T +
Sbjct: 626 RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685
Query: 1516 -------EKLIAELGRKEMEPKSH-HTLKIAHQTIANMQAR---LNQKEEVLKKYQRLLE 1564
EK ++L + +E + + +LK A +A +Q L ++E LKK LL
Sbjct: 686 TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL- 744
Query: 1565 KAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLA 1624
KA ++ E ++ + L I + RL+ ++S K +Q +L
Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD---------------L 789
Query: 1625 EMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENH-----EDE 1679
EME +++ L L + K++ Q LE++ + E + + E K QL++ + + E
Sbjct: 790 EMENQTLQKN--LEELKISSKRLEQ-LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Query: 1680 VKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRN--LVER----LKSQ 1733
+K E ++K + +KE++ L E+ KE+ R N LV+R +K+
Sbjct: 847 IKDTTLEENNVK--IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
Query: 1734 LALKEK--QQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQV 1791
+ L+E +K ++ + ++T E+ ++ KE L+ +Q D + L++++
Sbjct: 905 VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN----KERLLHDEQSTDDRYKLLESKL 960
Query: 1792 EDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELK 1851
E LK++L+ + + +L L + N Q+ ++ + + E + Q DE
Sbjct: 961 EST------LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-- 1012
Query: 1852 RQIKRLTSGLQGKPLTDNK-QSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELI 1910
++ + + + G+ DNK + +E R++ K++++L +VE + EK A + +
Sbjct: 1013 ERMVQSSPPISGE---DNKWERESQETTRELLKVKDRLI-EVERNNATLQAEKQALKTQL 1068
Query: 1911 RWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMT 1970
K+ + + ++ ++ + + +L +Q TL+ AK E TL + T+ M
Sbjct: 1069 -----KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ-STSLMN 1122
Query: 1971 VDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLH 2030
+ L I+ E E E + K DL++ LY DS+++D EKL
Sbjct: 1123 QNAQLLIQQSSLENENESVIKEREDLKS--LY---------DSLIKD--------HEKLE 1163
Query: 2031 ALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQ-LEQANKDLPRL 2089
L ++ + + S S G LK + +N+E++ + LE L +
Sbjct: 1164 LLHERQASEYESLISKHG----------------TLKSAHKNLEVEHRDLEDRYNQLLKQ 1207
Query: 2090 KNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPE---LEKTIGLMKKVVEKVQR 2146
K Q+ DL++M + +++EK ++ K H + K E L T + K E +Q
Sbjct: 1208 KGQLEDLEKMLK-VEQEKMLLENK-NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT 1265
Query: 2147 ENEQLKKASGI-----------------------LTSEKMANIEQENEKLKAELEKLKAH 2183
+++ LK +TS K+ N + +LK LE+ H
Sbjct: 1266 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1325
Query: 2184 LGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEE 2243
L Q+ E+ + + E ++ D +LR K LE E+
Sbjct: 1326 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLE----------EK 1375
Query: 2244 TGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEA 2303
+ +F + P+ G +W ++ + ++ ++K DI ++ Q L ++
Sbjct: 1376 IMDQYKFYDPSPPRRRG----NWITLKMRKLIKSK-----KDINRERQKSLTLTPTRSDS 1426
Query: 2304 TEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLR----LANHQLDKEKAELI 2359
+E ++ ++D + + + E +T K + L+ L N DK+K +
Sbjct: 1427 SEGFLQLP--HQDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKAC 1484
Query: 2360 HQ 2361
++
Sbjct: 1485 YR 1486
Score = 124 bits (312), Expect = 9e-28
Identities = 198/913 (21%), Positives = 390/913 (42%), Gaps = 144/913 (15%)
Query: 17 DLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKA 76
DL +++ + + +L + ++K +QEN HL + SL + E ++++EK
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENE-HLNQTVSSLRQRSQISAEARVKDIEKE 588
Query: 77 GEEQAKFENQLKTKVMKLENEL-----EMAQQSAGGRDTRFLRNEICQLEKQ-------- 123
+ + + +K+ K+E E E+ G L NE+ LEK+
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648
Query: 124 ------------LEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKK 171
LEQ++ ELE ++L+K + L + E E ENS+L EN L++
Sbjct: 649 TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRR 708
Query: 172 KNEQL-CQDIIDYQ-----KQIDSQKETLLS---------RRGEDSDYRSQ-LSKKNYEL 215
E L C + Q K+++S+KE L ++ E + Q L +N L
Sbjct: 709 NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRL 768
Query: 216 IQYLD----EIQTLTEANEKIEVQNQEMRKNLEE---SVQEMEKMTDEYNRMKAIVHQTD 268
+ L+ +IQ L + +E++NQ ++KNLEE S + +E++ E ++ Q +
Sbjct: 769 QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828
Query: 269 NVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSK----DDEI 324
QL+KEN + Q + +K E++ + + +E+ LS + +
Sbjct: 829 KDKKQLEKENKRLRQQAE-----IKDTTLEENNVKI---GNLEKENKTLSKEIGIYKESC 880
Query: 325 IEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCI 384
+ +++ +E +K A +D ++ L++ + + + + +E+ T E+EK
Sbjct: 881 VRLKELEKENKELVKRATIDI--KTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN 938
Query: 385 IEDLKNELQRNKGA-STLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKEL-- 441
E L ++ Q L + ++ +L+I +EK E E + ++ +EL
Sbjct: 939 KERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 998
Query: 442 ----VEALKRLKDYESGVYGL-----EDAVVEIKN---CKNQIKIRDREIEI------LT 483
EALK+ +D E V ED E ++ + +K++DR IE+ L
Sbjct: 999 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1058
Query: 484 KEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIE 543
E L+ ++ +N L+ ++ + + L E + + + + EN L +
Sbjct: 1059 AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQST 1118
Query: 544 SLEEERLDLKKKIRQMAQERGKRSATSGLTTEDL-NLTENISQGDRISERKLDLLSLKNM 602
SL + L I+Q + E S EDL +L +++ + KL+LL +
Sbjct: 1119 SLMNQNAQL--LIQQSSLENENESVIK--EREDLKSLYDSLIK----DHEKLELLHERQA 1170
Query: 603 SEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQ---AIK 659
SE +S LI K L+ + K L E++ LE+ ++L+ ++
Sbjct: 1171 SEYES--------LISKHGTLKSAH----------KNLEVEHRDLEDRYNQLLKQKGQLE 1212
Query: 660 EMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQEL 719
+++K + +E+ +E+KN E + L + D+L +L +E
Sbjct: 1213 DLEK------------MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET 1260
Query: 720 RESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINS 779
+ + N L + L+ LE E S L++ ++ +D+ +++ +N+
Sbjct: 1261 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ------YQQLDI-------TSTKLNN 1307
Query: 780 QNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKE-YLSEKETWKTESK 838
Q E L L LE + + L + +L NR +Q++ K+ + E+ + +
Sbjct: 1308 QCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLL----EQNMESKDLFHVEQRQYIDKLN 1363
Query: 839 TIKEEKRKLEDQV 851
++ +K KLE+++
Sbjct: 1364 ELRRQKEKLEEKI 1376
Score = 111 bits (277), Expect = 1e-23
Identities = 188/848 (22%), Positives = 353/848 (41%), Gaps = 147/848 (17%)
Query: 27 NLLISLSKVEVNELKSEKQENVIHLFRITQSLM--KMKAQEVELALEEVEKAGEEQAKFE 84
NL L +E S+ E + L R +SL MK +++L +E+E E+ K
Sbjct: 684 NLTFQLESLEKEN--SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
Query: 85 NQLKTKVMKLENELEMAQQSAGGRDTRFLRN------EICQLEKQLEQKDRELEDMEKEL 138
LK K E LE++ Q + R + +I QLE +L+ + E + ++K L
Sbjct: 742 ELLKASFKKTER-LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800
Query: 139 EKEK---KVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQ--DIIDYQKQ------- 186
E+ K K EQL N+ E E S+L ++ K+L+K+N++L Q +I D +
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
Query: 187 -IDSQKETLLSRRG---EDSDYRSQLSKKNYELIQYLD-EIQTLTEANEKI---EVQNQE 238
++ + +TL G E +L K+N EL++ +I+TL E + +++ Q+
Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
Query: 239 MRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEE 298
M +LE+ E+EK+ R+ TD D Y+L +L LK E
Sbjct: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTD----------DRYKLLESKLESTLKKSLEI 970
Query: 299 DDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQ 358
+ + A+ A++E E Y Q LR++LK K N AL+Q
Sbjct: 971 KEEKIAALEARLE-----------ESTNYNQ---QLRQELKTV-----KKNYEALKQ--- 1008
Query: 359 ERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKE 418
Q + M +++ I N+ +R SQ+T T ++LK
Sbjct: 1009 -------------RQDEERMVQSSPPISGEDNKWERE------SQET------TRELLKV 1043
Query: 419 KTK--EAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRD 476
K + E ER +A+ + +L + + + ++ + L+ V ++ ++ ++
Sbjct: 1044 KDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN 1103
Query: 477 REIEILTKEIN-----------KLELKISDFLDENEA-LRERVGLEPKTMID-LTEFRNS 523
++++ +N +L ++ S +ENE+ ++ER L K++ D L +
Sbjct: 1104 AKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL--KSLYDSLIKDHEK 1161
Query: 524 KHLKQQQYRAENQILLKE-------IESLEEERLDLKKKIRQMAQERGKRSATSGLTTED 576
L ++ +E + L+ + ++LE E DL+ + Q+ +++G+ ED
Sbjct: 1162 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ--------LED 1213
Query: 577 LNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNK 636
L + Q + E K + +N+ L+ + ++ E V+
Sbjct: 1214 LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE----VLQTDHKN 1269
Query: 637 LKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696
LK L+ +K + ++ +KE + D+ + + L +L +E +N
Sbjct: 1270 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENR----- 1324
Query: 697 ASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGS 756
HL Q+ L +N L ++ ES K+ + Q+ +++K L RQ E
Sbjct: 1325 ---HLLDQIQTLMLQNRTLLEQNMES-KDLFHVEQR--------QYIDKLNELRRQKE-- 1370
Query: 757 NVVFKGIDLPDGIAPS----SASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKF 812
+ K +D PS + I + LI +++ + +K L + D + F
Sbjct: 1371 KLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGF 1430
Query: 813 AVIRHQQS 820
+ HQ S
Sbjct: 1431 LQLPHQDS 1438
Score = 67.0 bits (162), Expect = 2e-10
Identities = 97/430 (22%), Positives = 181/430 (42%), Gaps = 82/430 (19%)
Query: 2038 KDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDL- 2096
K T S+ +S +E D + + L++E + + + ++ K +LEQ +L RL+ + +L
Sbjct: 241 KRTESRQHLS-VELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 2097 --KEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKA 2154
+ E ++ K V E I K VE+++ +N+ L +
Sbjct: 300 SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359
Query: 2155 SGILT---------SEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAE 2205
+L S+K+ +E+EN +LKA+L H + M + K E+++ E
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKL--------HDMEMERDMDRKKIEELMEE 411
Query: 2206 NERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKS 2265
N L K+ D E L + +LE+ SR +L A KS
Sbjct: 412 NMTLEMAQKQSMD--ESLHLGW------------ELEQI--------SRTSELSEAPQKS 449
Query: 2266 WKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKV---NKYNEDLEQQIK 2322
V + ++L +LE + +++ +L+ V K+ K N+ L ++++
Sbjct: 450 LGH-EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 2323 ILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLK 2382
IL++ E Q K+ LQ + + L KEKA+L IE ++ S
Sbjct: 509 ILEN-----EIVQE-KQSLQNCQNLSKDLMKEKAQLEKTIETLRENS------------- 549
Query: 2383 EKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLE 2442
E Q+K+ + E +HL + + L++ + + ++IE K+N +L
Sbjct: 550 ------ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE----------KENKILH 593
Query: 2443 EKVKKLSEQL 2452
E +K+ S +L
Sbjct: 594 ESIKETSSKL 603
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 165 bits (418), Expect = 5e-40
Identities = 259/1225 (21%), Positives = 539/1225 (44%), Gaps = 131/1225 (10%)
Query: 226 TEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQV 285
TE+ + + V+ + + + QE+E+ T++ K + Q + + +L++EN +
Sbjct: 243 TESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN------M 296
Query: 286 QELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLR-EKLKNAQLD 344
L+D ++ D+ ++A + E + + + E+ Y++ LH++ K + +L
Sbjct: 297 NLLSDARSARMYRDE-----LDA-LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350
Query: 345 ADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNE--LQRNKGASTLS 402
D ++ + ++++ + ++++ + KE + + D++ E + R K +
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410
Query: 403 QQTHMKIQSTLDI-----LKEKTKEAERTAELAEADAREKDKELVE-ALKRLKDYESGVY 456
+ +++ + L + ++ RT+EL+EA + E+ E RL E
Sbjct: 411 ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQ 470
Query: 457 GLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMID 516
L V E++ + ++ +I + KE +L K+ + ENE ++E+ L+
Sbjct: 471 SLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE--ILENEIVQEKQSLQ------ 522
Query: 517 LTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTED 576
N ++L + + + Q L K IE+L E + +++I+ + QE + T +
Sbjct: 523 -----NCQNLSKDLMKEKAQ-LEKTIETLRE---NSERQIKILEQENEHLNQTVSSLRQR 573
Query: 577 LNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNK 636
++ D E K+ S+K S SK EF R++ ++ + + +N+
Sbjct: 574 SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENE 633
Query: 637 LKELVEENKQLEEGMK------EILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKN 690
L L +EN+ L++ + E ++A+++ + + + + + S + L +ES
Sbjct: 634 LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLE 693
Query: 691 AEG--IFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETS 748
E + + +L L+ V+ L + ++ Q L+ KE + +QL K LE +
Sbjct: 694 KENSQLDEENLELRRNVESLKCASMKMAQ-LQLENKELESEKEQLKKG------LELLKA 746
Query: 749 LLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKL-KNLEDSLED 807
+++E V ++G+D+ + + N + + L LQ+LE + + L KNLE+
Sbjct: 747 SFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
Query: 808 YNRKFAVIRHQQSLLYKEYLSEKETWKTE--SKTIKEEKRKLEDQVQQDAIKVKEYNNLL 865
R + + +SL E+ET + E K +++E ++L Q + ++E N +
Sbjct: 807 SKRLEQLEKENKSL-------EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
Query: 866 NALQMDSDEMKK---ILAENSRKITVLQVNEKSLIRQYT----TLVELERQLRKENEK-- 916
L+ ++ + K I E+ ++ L+ K L+++ T TLV L L E K
Sbjct: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQ 919
Query: 917 QKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKY 976
Q N L EKIG KE + Q D+ L E +L E T K
Sbjct: 920 QMNNDLEKLTHELEKIGL---NKERLLHD---EQSTDDSRYKLLESKL------ESTLK- 966
Query: 977 RDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGN 1036
+ + K+ + + LE N L+++++++ K E K++ E+ + +
Sbjct: 967 KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR-QDEERMVQSSPPISG 1025
Query: 1037 ESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFE 1096
E + + + T +++ + K ++E++ N +AE + L+T LKQ+E +N
Sbjct: 1026 EDNKWERESQETTRELLKV--KDRLIEVERNNATLQAEK-----QALKTQLKQLETQNNN 1078
Query: 1097 LETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLR 1156
L+ + L + + Q+ L+ + ++ + + + L +L ++ S L
Sbjct: 1079 LQAQILALQRQTVSLQEQNTTLQTQ--NAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1136
Query: 1157 EISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAK---LHQHNVSLQLS 1213
++ ++ E L + S K+ E +++LL + S+ +SLI+K L + +L++
Sbjct: 1137 NENESVIKEREDLKSLYDSLIKDHE--KLELLHERQASEYESLISKHGTLKSAHKNLEVE 1194
Query: 1214 E----------ATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHL 1263
G+LE + K+ K+E + LE K + + A Y +L G N L
Sbjct: 1195 HRDLEDRYNQLLKQKGQLEDL-EKMLKVEQEKMLLENK-NHETVAAEYKKLCGEN--DRL 1250
Query: 1264 RQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMEL 1323
T L ++ L K K++ L N KL E + E ++ + ++++
Sbjct: 1251 NHTYSQLLKETE---VLQTDHKNLKSL--LNNSKL----EQTRLEAEFSKLKEQYQQLDI 1301
Query: 1324 KLKGLEELISTLKDTKGAQKVINWHM--KIEELRLQELKLNRELVKDK-----EEIKYLN 1376
L L KG + N H+ +I+ L LQ L + ++ K E+ +Y++
Sbjct: 1302 TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID 1361
Query: 1377 NIISEYERTISSLEEEIVQQNKFHE 1401
++E R LEE+I+ Q KF++
Sbjct: 1362 K-LNELRRQKEKLEEKIMDQYKFYD 1385
Score = 157 bits (396), Expect = 2e-37
Identities = 269/1194 (22%), Positives = 508/1194 (42%), Gaps = 208/1194 (17%)
Query: 1370 EEIKYLNNIISEYERTISSLEE--EIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNE 1427
EE+K L ++ EE E +Q F + +A +EV Q ++FD Q E
Sbjct: 119 EEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVT-HNQENVFDLQWME 177
Query: 1428 ILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESA 1487
+ + +Q+ E PL + + L+++ ++E+ + E+
Sbjct: 178 VTDMSQEDIE----------PLLKNMALHLKRL----------------IDERDEHSETI 211
Query: 1488 LRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQA 1547
+ L+E+ + L A++ + G K E + H ++++A + +A
Sbjct: 212 IELSEER--------DGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELA-----DAKA 258
Query: 1548 RLNQ-KEEVLKKYQRLLEKARE-EQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWD 1605
++ + ++E+ +K ++LL+ +E EQ EI K + + L +D+ + + D
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKR-----LQQENMNLLSDARSARMYRDELD 313
Query: 1606 LMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVK-- 1663
+++ +R+ ++E V+ + L + +V + E + + E K
Sbjct: 314 ALREKA---------VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
Query: 1664 -EFENIKLQLQENHEDEVK--KVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPT 1720
+ E + + + HE E + ++KA++ D++ D +K+ + L E + A ++
Sbjct: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
Query: 1721 TTMRN--LVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQ-KEAHLNVQ 1777
++ +E++ L E QK+L + EL + E S T +E V
Sbjct: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
Query: 1778 QIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKI- 1836
+ ++ LK + E N+ L K E L+ +E N +L+ +L K++ K
Sbjct: 485 SVEGNASKILKMEKE--NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542
Query: 1837 --LREKEE-----IDQENDELK------RQIKRLTSGLQGKPL-------------TDNK 1870
LRE E ++QEN+ L RQ ++++ + K + T +K
Sbjct: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
Query: 1871 QSLIEELQRKVKK--------------LENQLEGKVEEVDLKPMKEKNAKEELIRWEEGK 1916
S IE +R++KK LEN+L +E +L K N K + E +
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 1917 KWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQR---KLKTTGMTVDQ 1973
+ +++E KLK+ LT QL +L+ ++ D+E L L+R LK M + Q
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
Query: 1974 V-LGIRALESEKE-----LEELKK------------RNLDLENDILYMRAHQALPR---- 2011
+ L + LESEKE LE LK + LD+EN L + +
Sbjct: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
Query: 2012 DSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSE 2071
+S ++DL ++N+ LQ+ L L+ IS +R ++L+KEN L E
Sbjct: 783 ESELQDLEMENQTLQKNLEELK------------ISS-------KRLEQLEKENKSLEQE 823
Query: 2072 NIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELE 2131
+L+ KD +L+ + + L++ E E K+G++ ++ L
Sbjct: 824 TSQLE-------KDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKT------LS 870
Query: 2132 KTIGLMKKV---VEKVQRENEQLKKASGI-----------LTSEKMANIEQEN--EKLKA 2175
K IG+ K+ ++++++EN++L K + I L SEK+ + N EKL
Sbjct: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
Query: 2176 ELEKL---KAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKN---N 2229
ELEK+ K L H +S+ K E + + E+K+E AA + R+ ++ N
Sbjct: 931 ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN 990
Query: 2230 LEILNEKMTVQLEETGKRLQFAESR----GPQLEGADSKSWKSIVVTRMYETKLKELETD 2285
++ E TV+ + + E R P + G D+K + T K+K+ +
Sbjct: 991 QQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1050
Query: 2286 IAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLR 2345
+ + N ++ KQ +K T+ +Q + N Q + + + E L+ + L+
Sbjct: 1051 VERNNATLQAEKQALK--TQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1108
Query: 2346 LANHQLDKEKAELIHQ-----IEANKDQSGAESTIPDADQLK----EKIKDLETQLKMSD 2396
+ N L+ + L++Q I+ + ++ ES I + + LK IKD E K+
Sbjct: 1109 VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE---KLEL 1165
Query: 2397 LEKQHLKEEIKKLKKE--LENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKL 2448
L ++ E + K L++ + E DL+ Y + +K+ LE+ K L
Sbjct: 1166 LHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKML 1219
Score = 151 bits (382), Expect = 7e-36
Identities = 270/1336 (20%), Positives = 556/1336 (41%), Gaps = 184/1336 (13%)
Query: 260 MKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSS 319
++ + H +NV D LQ E+TD+ E+ +P++ + + K ++
Sbjct: 160 IQEVTHNQENVFD----------LQWMEVTDM---SQEDIEPLLKNMALHL---KRLIDE 203
Query: 320 KDD------EIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQ 373
+D+ E+ E + LH L +AQ M + Q ++ ++ +
Sbjct: 204 RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPG-MKRTESRQHLSVELADAKAKIRR 262
Query: 374 YTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQST----------LDILKEKT--- 420
+E+E+ T + D K EL++ + QQ +M + S LD L+EK
Sbjct: 263 LRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV 322
Query: 421 ----------KEAERTAELAEA---DAREKDKELVEALKRLKDYESGVYGLEDAVVEIKN 467
KE E +A + +E ++ L+E L+D G D + E++
Sbjct: 323 DKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEK 382
Query: 468 CKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHL- 526
Q+K + ++E+ E + KI + ++EN L M S HL
Sbjct: 383 ENLQLKAKLHDMEM---ERDMDRKKIEELMEENMTLE---------MAQKQSMDESLHLG 430
Query: 527 -KQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQ 585
+ +Q +++ +SL E +L R + E +S T T E+L T + +
Sbjct: 431 WELEQISRTSELSEAPQKSLGHEVNELTSS-RLLKLEMENQSLTK--TVEELRTTVDSVE 487
Query: 586 GDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENK 645
G+ K++ K K E L E++++++ L+ QN K+L++E
Sbjct: 488 GNASKILKME----KENQRLSKKVEILENEIVQEKQSLQNC-------QNLSKDLMKEKA 536
Query: 646 QLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQV 705
QLE+ ++ + + + K + + + + SL + + I + L +
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596
Query: 706 DQLTGRNEELRQELRESRKEAINYSQQLAKA---NLKIDHLEKETSLLRQSEGSNVVFKG 762
+ + + ++ E R+ +KE +Y ++ +A ++ HLEKE LL++
Sbjct: 597 KETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK--------- 647
Query: 763 IDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLL 822
++ I + E L ELE + +KLK DS ++ + + + S L
Sbjct: 648 --------ITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 699
Query: 823 YKEYLSEKETWKT-------------ESKTIKEEKRKLEDQVQQDAIKVKEYNNL---LN 866
+E L + ++ E+K ++ EK +L+ ++ K+ L
Sbjct: 700 DEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQ 759
Query: 867 ALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVE-LE---------RQLRKENEK 916
L +++ ++K L +++KI L+ + L + TL + LE QL KEN+
Sbjct: 760 GLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
Query: 917 QKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQ-------Y 969
+ E +E + + +R ++ A K L+ +N+V + LE NK Y
Sbjct: 820 LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLE---ENNVKIGNLEKENKTLSKEIGIY 876
Query: 970 NELTAKYRDILQKDNMLVQRTS----NLEHLECENISLKEQVESINKELEITKEKLHTIE 1025
E + +++ +++ LV+R + L L + +S K + + +N +LE +L I
Sbjct: 877 KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI- 935
Query: 1026 QAWEQETKLGNESSMDKAKKSITNSDIVS-ISKKITMLEMKELNERQRAEHCQKMYEHLR 1084
+E L +E S D ++ + S + S + K + + E K R E + LR
Sbjct: 936 -GLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR 994
Query: 1085 TSLKQMEERNFELETKFAE--LTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELE 1142
LK +++ L+ + E + + + + E ++ + + D R++E+E
Sbjct: 995 QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKD--RLIEVE 1052
Query: 1143 KNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAK 1202
+N L+ E L + Q++ L Q + ++ +L+ Q + Q Q+
Sbjct: 1053 RNNATLQAEKQAL-------KTQLKQLETQNNNLQAQILALQRQTVSLQEQN------TT 1099
Query: 1203 LHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKH 1262
L N LQ+ +T L S ++ L A L + L+ + +++ R +
Sbjct: 1100 LQTQNAKLQVENST----LNSQSTSLMNQNAQLLIQQSSLENENESVIKER-------ED 1148
Query: 1263 LRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEME 1322
L+ SL + L +++ + ++ LK KN + EHR++E++ ++
Sbjct: 1149 LKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLK--SAHKNLEVEHRDLEDRYNQL- 1205
Query: 1323 LKLKG-LEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISE 1381
LK KG LE+L LK + +K++ + E + + KL E D+ Y + ++ E
Sbjct: 1206 LKQKGQLEDLEKMLKVEQ--EKMLLENKNHETVAAEYKKLCGE--NDRLNHTY-SQLLKE 1260
Query: 1382 YE--RTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEAT 1439
E +T + ++ +K + R A + + +QLDI + N N + +
Sbjct: 1261 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN---NQCELLSQLK 1317
Query: 1440 GSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRD 1499
G++ + + L +Q++ + + + + +E++ + + +K + LR ++ + +
Sbjct: 1318 GNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKL--EE 1375
Query: 1500 KVINELRLRLPATAER 1515
K++++ + P+ R
Sbjct: 1376 KIMDQYKFYDPSPPRR 1391
Score = 151 bits (381), Expect = 9e-36
Identities = 258/1234 (20%), Positives = 535/1234 (43%), Gaps = 149/1234 (12%)
Query: 116 EICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQ 175
E+ + ++ + +ELE+ ++L K+ EQ+ + + + EN L + + +
Sbjct: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARM---- 307
Query: 176 LCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANEKIEVQ 235
Y+ ++D+ +E + +S+ S+ ++ +++ Y ++ L E N+ +
Sbjct: 308 -------YRDELDALREKAVRVDKLESEV-SRYKERLHDIEFYKARVEELKEDNQVL--- 356
Query: 236 NQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSK 295
E + LE+ ++ +D+ + ++ Q + ++ E D + +++EL
Sbjct: 357 -LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM------ 409
Query: 296 NEEDDPIMVAVNAKVEE-----WKLILSSKDDEIIEYQQ--MLHNLREKLKNAQLDADKS 348
EE+ + +A ++E W+L S+ E+ E Q + H + E + L +
Sbjct: 410 -EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
Query: 349 NVMALQQGIQERDSQIKML---TEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQT 405
N +L + ++E + + + ++ + KE ++ + +E L+NE+ + K + Q
Sbjct: 469 N-QSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 406 HMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLE--DAVV 463
+ D++KEK + E+T E ++ + K L + + L S + A
Sbjct: 528 ------SKDLMKEKA-QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 464 EIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNS 523
+K+ + + KI I+ + +++K+E + E E +E+ + +L
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
Query: 524 KHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMA-----------QERGKRSATSGL 572
L Q++ +I ++IE+LE+E +L+++ R++ Q S L
Sbjct: 641 NELLQKKI-TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQL 699
Query: 573 TTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAK 632
E+L L N+ + + + K+ L L+N E +S+ E L + L + +++ +
Sbjct: 700 DEENLELRRNV-ESLKCASMKMAQLQLEN-KELESEKEQLKKGLELLKASFKKTERLEVS 757
Query: 633 FQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAE 692
+Q E K LE K+I Q E+Q D ++ E + +LE L I SK E
Sbjct: 758 YQGLDIENQRLQKTLENSNKKIQQLESELQ-DLEM---ENQTLQKNLEEL--KISSKRLE 811
Query: 693 GIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQ 752
+ + L+ + QL ++L +E + R++A L + N+KI +LEKE L +
Sbjct: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
Query: 753 SEG----SNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDY 808
G S V K ++ + A+I + L+ L ++L +++ K + + + LE
Sbjct: 872 EIGIYKESCVRLKELEKENKELVKRATI---DIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
Query: 809 NRKFAVI-RHQQSLLYKEYLSEKETWK-TESK---TIKEEKRKLEDQVQQDAIKVKEYNN 863
+ I +++ LL+ E ++ +K ESK T+K+ E+++ +++E N
Sbjct: 929 THELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 988
Query: 864 LLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLS 923
L+ + +KK N + Q +E+ +++ + + + +E+++ ELL
Sbjct: 989 YNQQLRQELKTVKK----NYEALKQRQ-DEERMVQSSPPISGEDNKWERESQETTRELLK 1043
Query: 924 MEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDI-LQK 982
++ + E E + A ++ + + E + N Q L + + + LQ+
Sbjct: 1044 VKDRLIE--------VERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQE 1095
Query: 983 DNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDK 1042
N +Q T N + L+ EN +L Q S+ ++ Q Q++ L NE+
Sbjct: 1096 QNTTLQ-TQNAK-LQVENSTLNSQSTSL----------MNQNAQLLIQQSSLENENESVI 1143
Query: 1043 AKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEH--LRTSLKQMEERNFELETK 1100
++ S S+ K LE+ L+ERQ +E+ + +H L+++ K +E + +LE +
Sbjct: 1144 KEREDLKSLYDSLIKDHEKLEL--LHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR 1201
Query: 1101 FAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISD 1160
+ +L K + +E+ML+ +++++L KN + E KL +D
Sbjct: 1202 YNQLLKQKGQLEDLEKMLK-------------VEQEKMLLENKNHETVAAEYKKLCGEND 1248
Query: 1161 IARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGK 1220
LN KE E L Q+D K+L + L+ + EA +
Sbjct: 1249 -------RLNHTYSQLLKETEVL---------QTDHKNLKSLLNNSKLEQTRLEA----E 1288
Query: 1221 LESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPL 1280
+ + Q+++ + +L + + Q LE NR HL IQ+L Q L
Sbjct: 1289 FSKLKEQYQQLDITSTKLNNQCELLSQ--LKGNLEEENR--HLLDQIQTLMLQ---NRTL 1341
Query: 1281 AQQEKFSKTMIQLQN----DKLKIMQEMKNSQQE 1310
+Q SK + ++ DKL ++ K +E
Sbjct: 1342 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1375
Score = 151 bits (381), Expect = 9e-36
Identities = 259/1162 (22%), Positives = 494/1162 (42%), Gaps = 202/1162 (17%)
Query: 22 EELADNLLI---SLSKVEVNELKSEKQENV--------IHLFRITQSLMKMKAQEVELAL 70
EE + LL L ++E+ ELK +QEN+ ++R ++ KA V+
Sbjct: 268 EEKTEQLLDCKQELEQMEI-ELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLE 326
Query: 71 EEVE------------KAGEEQAKFENQ--LKTKVMKLENELEMAQQSAGGRDTRFLRNE 116
EV KA E+ K +NQ L+TK M LE++LE TR ++
Sbjct: 327 SEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM-LEDQLE---------GTRARSDK 376
Query: 117 ICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKKKNEQL 176
+ +LEK+ Q +L DME E + ++K E+L N E + E+ L + EQ+
Sbjct: 377 LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQI 436
Query: 177 CQ--DIIDY-QKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQTLTEANE--- 230
+ ++ + QK + + L S R +L +N L + ++E++T ++ E
Sbjct: 437 SRTSELSEAPQKSLGHEVNELTSSR------LLKLEMENQSLTKTVEELRTTVDSVEGNA 490
Query: 231 ----KIEVQNQEMRKNLE----------ESVQEMEKMTDEYNRMKAIVHQT--------D 268
K+E +NQ + K +E +S+Q + ++ + + KA + +T +
Sbjct: 491 SKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE 550
Query: 269 NVIDQLKKENDHYQLQVQELTD--------LLKSKNEEDDPIMVAVN------AKVEEWK 314
I L++EN+H V L +K +E+ + ++ +K+E K
Sbjct: 551 RQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEK 610
Query: 315 LIL-------SSKDDEIIEYQQMLHN-------LREKLKNAQLDADKSNVMALQQGIQER 360
+ K + E + LH+ L++K+ N ++ +K + AL+Q E
Sbjct: 611 RQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEK--IEALEQENSEL 668
Query: 361 DSQIKMLTEQVEQY------TKEMEKNTCIIEDLKNELQRN----KGASTLSQQTHM--- 407
+ + + L + ++ + + +EK +++ EL+RN K AS Q +
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENK 728
Query: 408 -------KIQSTLDILK---EKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYG 457
+++ L++LK +KT+ E + + + + + K L + K+++ ES +
Sbjct: 729 ELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD 788
Query: 458 LEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKIS-------DFLDENEALRERVGLE 510
LE ++ ++KI + +E L KE LE + S EN+ LR++ ++
Sbjct: 789 LEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIK 848
Query: 511 PKTM------IDLTEFRNSKHLKQQQYRAENQILLKEIESLEEE-----RLDLKKKIRQM 559
T+ I E N K+ E+ + LKE+E +E +D+K +
Sbjct: 849 DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR 908
Query: 560 AQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEK 619
++ T + + LT + + ER L S S+ + L +L
Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH----DEQSTDDSRYKLLESKLEST 964
Query: 620 -ERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEI---LQAIKE-------MQKDPDVK 668
++ LE IA + +L+E N+QL + +K + +A+K+ +Q P +
Sbjct: 965 LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPIS 1024
Query: 669 GGE----------TSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQE 718
G + T ++ +RL+ +E NA + LK Q+ QL +N L+ +
Sbjct: 1025 GEDNKWERESQETTRELLKVKDRLIE-VERNNAT-LQAEKQALKTQLKQLETQNNNLQAQ 1082
Query: 719 LRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIIN 778
+ +++ ++ +Q + L+ E S L S S++N
Sbjct: 1083 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS-------------------QSTSLMN 1123
Query: 779 SQNEYLIHLLQELENKEKK-------LKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKE 831
QN L+ LEN+ + LK+L DSL + K ++ +Q+ Y+ +S+
Sbjct: 1124 -QNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHG 1182
Query: 832 TWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQV 891
T K+ K ++ E R LED+ Q +K+ L + +M E +K+L EN TV
Sbjct: 1183 TLKSAHKNLEVEHRDLEDRYNQ---LLKQKGQLEDLEKMLKVEQEKMLLENKNHETV-AA 1238
Query: 892 NEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEV-CEKIGCLQRFKEMAIFKIAALQ 950
K L + L QL KE E + + ++++ + K+ + E + K Q
Sbjct: 1239 EYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQ 1298
Query: 951 KVVDNSVSLSELELANKQYNELTAKYRDILQKDN--MLVQRTSNLEHLECENISLKEQVE 1008
+ ++ ++ EL ++ L + R +L + ML RT +++E +++ EQ +
Sbjct: 1299 LDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQ 1358
Query: 1009 SINKELEITKEKLHTIEQAWEQ 1030
I+K E+ ++K E+ +Q
Sbjct: 1359 YIDKLNELRRQKEKLEEKIMDQ 1380
Score = 140 bits (352), Expect = 2e-32
Identities = 300/1448 (20%), Positives = 598/1448 (41%), Gaps = 265/1448 (18%)
Query: 947 AALQKVVDNSVSLSELELANKQYNELTAKYRDILQKD--NMLVQRTSNLEHLECENISLK 1004
A +Q+V N ++ +L Q+ E+T D+ Q+D +L +L+ L E
Sbjct: 158 AHIQEVTHNQENVFDL-----QWMEVT----DMSQEDIEPLLKNMALHLKRLIDERDEHS 208
Query: 1005 EQVESINKELEITKEKLHTIEQAWEQ-ETKLGNESSMDKAKKSITNSDIVSISKKITMLE 1063
E + +++E ++ LH + A ++ G+ + + ++ KI L
Sbjct: 209 ETIIELSEE----RDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLR 264
Query: 1064 MKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELA 1123
+ + ++ C++ E + LK++++ N L L + +M RDEL
Sbjct: 265 QELEEKTEQLLDCKQELEQMEIELKRLQQENMNL-----------LSDARSARMYRDEL- 312
Query: 1124 DSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESL 1183
DA R++ + ++K E E+ +L +I + + +VE L Q + L
Sbjct: 313 --------DALREKAVRVDKLESEVSRYKERLHDI-EFYKARVEELKEDNQVLLETKTML 363
Query: 1184 RMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLD 1243
QL +A+SD+ + +L + N+ L+ +KL ME +K++
Sbjct: 364 EDQLEGTRARSDK---LHELEKENLQLK--------------AKLHDMEMERDMDRKKIE 406
Query: 1244 E---KEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKI 1300
E + L A+ + + + HL ++ + R + L A Q+ + +L + +L
Sbjct: 407 ELMEENMTLEMAQKQSMDESLHLGWELEQISR--TSELSEAPQKSLGHEVNELTSSRLLK 464
Query: 1301 MQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKG-AQKVINWHMKIEELRLQEL 1359
++ MEN++L K +EEL +T+ +G A K++ + + L +
Sbjct: 465 LE-----------MENQSLT-----KTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 1360 KLNRELVKDKEEIKYLNNII-------SEYERTISSLEEEIVQQNKFHEERQMAWDQREV 1412
L E+V++K+ ++ N+ ++ E+TI +L E +Q K E+ +Q
Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
Query: 1413 DLERQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRA 1472
L ++ I + + + K SI + S L +++E R+IK+ + E
Sbjct: 569 SLRQRSQISAEARVKDIEKENKILHE--SIKETSSKL-SKIEFEKRQIKKELEHYKEKGE 625
Query: 1473 TCKSLE----------EKLKEKESALRLAEQNILSRDKVINELRL---RLPATAER---- 1515
+ LE E L++K + L++ + I + ++ +EL +L T +
Sbjct: 626 RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685
Query: 1516 -------EKLIAELGRKEMEPKSH-HTLKIAHQTIANMQAR---LNQKEEVLKKYQRLLE 1564
EK ++L + +E + + +LK A +A +Q L ++E LKK LL
Sbjct: 686 TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL- 744
Query: 1565 KAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLA 1624
KA ++ E ++ + L I + RL+ ++S K +Q +L
Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD---------------L 789
Query: 1625 EMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENH-----EDE 1679
EME +++ L L + K++ Q LE++ + E + + E K QL++ + + E
Sbjct: 790 EMENQTLQKN--LEELKISSKRLEQ-LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Query: 1680 VKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEK 1739
+K E ++K + +KE++ L E+ KE+ RLK L+++
Sbjct: 847 IKDTTLEENNVK--IGNLEKENKTLSKEIGIYKES------------CVRLKE---LEKE 889
Query: 1740 QQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLL 1799
++ + RA ++++ +T + S+K + +++ T EL+ LN+ L
Sbjct: 890 NKELVKRATIDIKTLVTLRED-----LVSEKLKTQQMNNDLEKLTHELEKI--GLNKERL 942
Query: 1800 KLKEALKTSKNRENSLTDNLND-LNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLT 1858
L + T +R L L L L+ K++ + EE N +L++++K +
Sbjct: 943 -LHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVK 1001
Query: 1859 SGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKW 1918
+ +++ +++ + +N+ E + +E + +K K+ E+ R
Sbjct: 1002 KNYEALKQRQDEERMVQS-SPPISGEDNKWERESQETTRELLKVKDRLIEVER--NNATL 1058
Query: 1919 QAKIEGIRNKLKEKEGE--------------VFTLTKQLNTLKDLFAKADKEKLTLQRKL 1964
QA+ + ++ +LK+ E + +L +Q TL+ AK E TL +
Sbjct: 1059 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ- 1117
Query: 1965 KTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRY 2024
T+ M + L I+ E E E + K DL++ LY DS+++D
Sbjct: 1118 STSLMNQNAQLLIQQSSLENENESVIKEREDLKS--LY---------DSLIKD------- 1159
Query: 2025 LQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQ-LEQAN 2083
EKL L ++ + + S S G LK + +N+E++ + LE
Sbjct: 1160 -HEKLELLHERQASEYESLISKHG----------------TLKSAHKNLEVEHRDLEDRY 1202
Query: 2084 KDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPE---LEKTIGLMKKV 2140
L + K Q+ DL++M + +++EK ++ K H + K E L T + K
Sbjct: 1203 NQLLKQKGQLEDLEKMLK-VEQEKMLLENK-NHETVAAEYKKLCGENDRLNHTYSQLLKE 1260
Query: 2141 VEKVQRENEQLKKASGI-----------------------LTSEKMANIEQENEKLKAEL 2177
E +Q +++ LK +TS K+ N + +LK L
Sbjct: 1261 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL 1320
Query: 2178 EKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKM 2237
E+ HL Q+ E+ + + E ++ D +LR K LE
Sbjct: 1321 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLE------ 1374
Query: 2238 TVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLK 2297
E+ + +F + P+ G +W ++ + ++ ++K DI ++ Q L
Sbjct: 1375 ----EKIMDQYKFYDPSPPRRRG----NWITLKMRKLIKSK-----KDINRERQKSLTLT 1421
Query: 2298 QLVKEATE 2305
+++E
Sbjct: 1422 PTRSDSSE 1429
Score = 125 bits (313), Expect = 7e-28
Identities = 198/914 (21%), Positives = 391/914 (42%), Gaps = 145/914 (15%)
Query: 17 DLPRQEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKA 76
DL +++ + + +L + ++K +QEN HL + SL + E ++++EK
Sbjct: 530 DLMKEKAQLEKTIETLRENSERQIKILEQENE-HLNQTVSSLRQRSQISAEARVKDIEKE 588
Query: 77 GEEQAKFENQLKTKVMKLENEL-----EMAQQSAGGRDTRFLRNEICQLEKQ-------- 123
+ + + +K+ K+E E E+ G L NE+ LEK+
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKI 648
Query: 124 ------------LEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRRENKRLKK 171
LEQ++ ELE ++L+K + L + E E ENS+L EN L++
Sbjct: 649 TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRR 708
Query: 172 KNEQL-CQDIIDYQ-----KQIDSQKETLLS---------RRGEDSDYRSQ-LSKKNYEL 215
E L C + Q K+++S+KE L ++ E + Q L +N L
Sbjct: 709 NVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRL 768
Query: 216 IQYLD----EIQTLTEANEKIEVQNQEMRKNLEE---SVQEMEKMTDEYNRMKAIVHQTD 268
+ L+ +IQ L + +E++NQ ++KNLEE S + +E++ E ++ Q +
Sbjct: 769 QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLE 828
Query: 269 NVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSK----DDEI 324
QL+KEN + Q + +K E++ + + +E+ LS + +
Sbjct: 829 KDKKQLEKENKRLRQQAE-----IKDTTLEENNVKI---GNLEKENKTLSKEIGIYKESC 880
Query: 325 IEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCI 384
+ +++ +E +K A +D ++ L++ + + + + +E+ T E+EK
Sbjct: 881 VRLKELEKENKELVKRATIDI--KTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN 938
Query: 385 IEDLKNELQRNKGA--STLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKEL- 441
E L ++ Q + L + ++ +L+I +EK E E + ++ +EL
Sbjct: 939 KERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELK 998
Query: 442 -----VEALKRLKDYESGVYGL-----EDAVVEIKN---CKNQIKIRDREIEI------L 482
EALK+ +D E V ED E ++ + +K++DR IE+ L
Sbjct: 999 TVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1058
Query: 483 TKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEI 542
E L+ ++ +N L+ ++ + + L E + + + + EN L +
Sbjct: 1059 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1118
Query: 543 ESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDL-NLTENISQGDRISERKLDLLSLKN 601
SL + L I+Q + E S EDL +L +++ + KL+LL +
Sbjct: 1119 TSLMNQNAQL--LIQQSSLENENESVIK--EREDLKSLYDSLIK----DHEKLELLHERQ 1170
Query: 602 MSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQ---AI 658
SE +S LI K L+ + K L E++ LE+ ++L+ +
Sbjct: 1171 ASEYES--------LISKHGTLKSAH----------KNLEVEHRDLEDRYNQLLKQKGQL 1212
Query: 659 KEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQE 718
++++K + +E+ +E+KN E + L + D+L +L +E
Sbjct: 1213 EDLEK------------MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1260
Query: 719 LRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIIN 778
+ + N L + L+ LE E S L++ ++ +D+ +++ +N
Sbjct: 1261 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ------YQQLDI-------TSTKLN 1307
Query: 779 SQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKE-YLSEKETWKTES 837
+Q E L L LE + + L + +L NR +Q++ K+ + E+ + +
Sbjct: 1308 NQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLL----EQNMESKDLFHVEQRQYIDKL 1363
Query: 838 KTIKEEKRKLEDQV 851
++ +K KLE+++
Sbjct: 1364 NELRRQKEKLEEKI 1377
Score = 111 bits (278), Expect = 8e-24
Identities = 192/901 (21%), Positives = 374/901 (41%), Gaps = 149/901 (16%)
Query: 27 NLLISLSKVEVNELKSEKQENVIHLFRITQSLM--KMKAQEVELALEEVEKAGEEQAKFE 84
NL L +E S+ E + L R +SL MK +++L +E+E E+ K
Sbjct: 684 NLTFQLESLEKEN--SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
Query: 85 NQLKTKVMKLENELEMAQQSAGGRDTRFLRN------EICQLEKQLEQKDRELEDMEKEL 138
LK K E LE++ Q + R + +I QLE +L+ + E + ++K L
Sbjct: 742 ELLKASFKKTER-LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800
Query: 139 EKEK---KVNEQLALRNEEAENENSKLRRENKRLKKKNEQLCQ--DIIDYQKQ------- 186
E+ K K EQL N+ E E S+L ++ K+L+K+N++L Q +I D +
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
Query: 187 -IDSQKETLLSRRG---EDSDYRSQLSKKNYELIQYLD-EIQTLTEANEKI---EVQNQE 238
++ + +TL G E +L K+N EL++ +I+TL E + +++ Q+
Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
Query: 239 MRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEE 298
M +LE+ E+EK+ R+ + D+ ++ Y+L +L LK E
Sbjct: 921 MNNDLEKLTHELEKIGLNKERL---------LHDEQSTDDSRYKLLESKLESTLKKSLEI 971
Query: 299 DDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQ 358
+ + A+ A++E E Y Q LR++LK K N AL+Q
Sbjct: 972 KEEKIAALEARLE-----------ESTNYNQ---QLRQELKTV-----KKNYEALKQ--- 1009
Query: 359 ERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKE 418
Q + M +++ I N+ +R SQ+T T ++LK
Sbjct: 1010 -------------RQDEERMVQSSPPISGEDNKWERE------SQET------TRELLKV 1044
Query: 419 KTK--EAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRD 476
K + E ER +A+ + +L + + + ++ + L+ V ++ ++ ++
Sbjct: 1045 KDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN 1104
Query: 477 REIEILTKEIN-----------KLELKISDFLDENEA-LRERVGLEPKTMID-LTEFRNS 523
++++ +N +L ++ S +ENE+ ++ER L K++ D L +
Sbjct: 1105 AKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDL--KSLYDSLIKDHEK 1162
Query: 524 KHLKQQQYRAENQILLKE-------IESLEEERLDLKKKIRQMAQERGKRSATSGLTTED 576
L ++ +E + L+ + ++LE E DL+ + Q+ +++G+ ED
Sbjct: 1163 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ--------LED 1214
Query: 577 LNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNK 636
L + Q + E K + +N+ L+ + ++ E V+
Sbjct: 1215 LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE----VLQTDHKN 1270
Query: 637 LKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFD 696
LK L+ +K + ++ +KE + D+ + + L +L +E +N
Sbjct: 1271 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENR----- 1325
Query: 697 ASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGS 756
HL Q+ L +N L ++ ES K+ + Q+ +++K L RQ E
Sbjct: 1326 ---HLLDQIQTLMLQNRTLLEQNMES-KDLFHVEQR--------QYIDKLNELRRQKE-- 1371
Query: 757 NVVFKGIDLPDGIAPS----SASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKF 812
+ K +D PS + I + LI +++ + +K L + D + F
Sbjct: 1372 KLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGF 1431
Query: 813 AVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDS 872
+ HQ S ++ S + +T+ +K + + Q + ++ L++
Sbjct: 1432 LQLPHQDS---QDSSSVGSNSLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTENLEVPD 1488
Query: 873 D 873
D
Sbjct: 1489 D 1489
Score = 67.0 bits (162), Expect = 2e-10
Identities = 97/430 (22%), Positives = 181/430 (42%), Gaps = 82/430 (19%)
Query: 2038 KDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDL- 2096
K T S+ +S +E D + + L++E + + + ++ K +LEQ +L RL+ + +L
Sbjct: 241 KRTESRQHLS-VELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLL 299
Query: 2097 --KEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKA 2154
+ E ++ K V E I K VE+++ +N+ L +
Sbjct: 300 SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET 359
Query: 2155 SGILT---------SEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAE 2205
+L S+K+ +E+EN +LKA+L H + M + K E+++ E
Sbjct: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKL--------HDMEMERDMDRKKIEELMEE 411
Query: 2206 NERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKS 2265
N L K+ D E L + +LE+ SR +L A KS
Sbjct: 412 NMTLEMAQKQSMD--ESLHLGW------------ELEQI--------SRTSELSEAPQKS 449
Query: 2266 WKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKV---NKYNEDLEQQIK 2322
V + ++L +LE + +++ +L+ V K+ K N+ L ++++
Sbjct: 450 LGH-EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 2323 ILKHVPEGAETEQGLKRELQVLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLK 2382
IL++ E Q K+ LQ + + L KEKA+L IE ++ S
Sbjct: 509 ILEN-----EIVQE-KQSLQNCQNLSKDLMKEKAQLEKTIETLRENS------------- 549
Query: 2383 EKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLE 2442
E Q+K+ + E +HL + + L++ + + ++IE K+N +L
Sbjct: 550 ------ERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE----------KENKILH 593
Query: 2443 EKVKKLSEQL 2452
E +K+ S +L
Sbjct: 594 ESIKETSSKL 603
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 164 bits (416), Expect = 8e-40
Identities = 257/1234 (20%), Positives = 518/1234 (41%), Gaps = 150/1234 (12%)
Query: 1244 EKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQE 1303
+K+Q L ++ RN A +L+ R F+ PL Q + + + + LK+ ++
Sbjct: 808 KKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEK 867
Query: 1304 MKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQEL--KL 1361
+ E ME K ++ + L E + + + + + ++ L+E+ L
Sbjct: 868 QTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDL 927
Query: 1362 NRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIF 1421
+ +++E + L N + + I LEE++ ++ ++ Q+ +V E ++
Sbjct: 928 ESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQL----EKVTAEAKIKKM 983
Query: 1422 DRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKL 1481
+ + + + KF + + D +QL K K +I + LEE+L
Sbjct: 984 EEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERL 1043
Query: 1482 KEKESALRLAEQ--------------NILSRDKVINELRLRLPATAEREKLIAELGRKEM 1527
K++E + E+ I I+EL+L+L + E+L L R +
Sbjct: 1044 KKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQL--AKKEEELQGALARGDD 1101
Query: 1528 EP-KSHHTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHH 1586
E ++ LK+ + +QA++ + +E + + KA +++R++ E+L L
Sbjct: 1102 ETLHKNNALKV----VRELQAQIAELQEDFESEKASRNKAEKQKRDL----SEELEALKT 1153
Query: 1587 RLELQADSSL------NKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSL 1640
LE D++ K +Q +L K T H ++ +M Q A + LS
Sbjct: 1154 ELEDTLDTTAAQQELRTKREQEVAELKK--ALEEETKNHEAQIQDMRQRHATALEELSEQ 1211
Query: 1641 LVKLKKVSQDLERQREITELKVKEFE---NIKLQLQENHEDEVKKVKAEVEDLKYLLDQS 1697
L + K+ +LE+ ++ E KE + Q++ E + KK+ A+V++L + +
Sbjct: 1212 LEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEG 1271
Query: 1698 QKESQCLKSEL--QAQKEANSRAPTTTMRNLVER-----------LKSQLALKEKQQKAL 1744
+ L+ EL +A K N +T+ E+ L+SQL ++ +
Sbjct: 1272 DR----LRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEE 1327
Query: 1745 SRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEA 1804
+R L L + + EE+ S Q+E ++ +++ L++Q+ D + +
Sbjct: 1328 TRQKLNLSSRIRQLEEEK-NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGT 1386
Query: 1805 LKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGK 1864
+++ + + L + L+ L++K AY+K+ + K + QE D+L +
Sbjct: 1387 IESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL---------- 1436
Query: 1865 PLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKEELIRWEEGKKWQAKIEG 1924
D+++ + L++K KK + QL + + + + +E++ E R E+ K +
Sbjct: 1437 ---DHQRQVASNLEKKQKKFD-QLLAEEKSISARYAEERDRAEAEAR-EKETKALSLARA 1491
Query: 1925 IRNKLKEKEGEVFTLTKQLNT-LKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRAL--E 1981
+ L+ KE E KQL ++DL + D + K+ QV +R E
Sbjct: 1492 LEEALEAKE-EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEE 1550
Query: 1982 SEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTY 2041
E EL+ + L LE ++ M+A DL ++ +EK L KQ +
Sbjct: 1551 LEDELQATEDAKLRLEVNMQAMKA-------QFERDLQTRDEQNEEKKRLLIKQVRE--- 1600
Query: 2042 SKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCE 2101
+ D+ QR + + K+ + +L+ Q+E ANK + Q+R L+ +
Sbjct: 1601 ----LEAELEDERKQRALAVASKK-KMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 2102 FLKKEKAEVQRKLGHVRGSGRSGK--------TIPELEKTIGLMKKVVEKVQRENEQLKK 2153
++E E + + + + I +L++ + ++ ++E ++L
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD 1715
Query: 2154 ASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKEL 2213
S K A ++ E +L+A + +L+ L + S + E K + + L EL
Sbjct: 1716 EITNSASGKSALLD-EKRRLEARIAQLEEELEEEQS-NMELLNDRFRKTTLQVDTLNAEL 1773
Query: 2214 KKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTR 2273
E AA+K A+ LE N+++ +L+E LEGA +K+ +
Sbjct: 1774 AAERSAAQKSDNARQQLERQNKELKAKLQE--------------LEGAVKSKFKATI--S 1817
Query: 2274 MYETKLKELETDIAKK-----------NQSITDLKQLVKEATEREQKVNKYNEDLEQ--- 2319
E K+ +LE + ++ ++ LK++ + + + ++Y E +E+
Sbjct: 1818 ALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANA 1877
Query: 2320 QIKILKHVPEGAETE--------QGLKRELQVLRLANHQLDKEKAELIHQ------IEAN 2365
++K LK E AE E + L+REL AN L +E + L ++ I +
Sbjct: 1878 RMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFS 1937
Query: 2366 KDQSGAESTIPDADQLKEKIKDLETQLKMSDLEK 2399
+SG + L ++ D +T+ K SD+ +
Sbjct: 1938 SSRSGRRQLHLEGASL--ELSDDDTESKTSDVNE 1969
Score = 152 bits (383), Expect = 5e-36
Identities = 260/1224 (21%), Positives = 523/1224 (42%), Gaps = 162/1224 (13%)
Query: 51 LFRITQSLMKMKAQEVELAL--EEVEKAGEEQAKFENQLKTKVMKLENELE----MAQQS 104
+F + L+++ QE EL EE+ K E+Q K E +L+ K + LE +A+Q
Sbjct: 837 VFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQL 896
Query: 105 AGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALRNEEAENENSKLRR 164
+ L E ++ +L K +ELE++ +LE + E+ RN+ +NE K++
Sbjct: 897 QAETE---LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEE---RNQILQNEKKKMQA 950
Query: 165 ENKRLKKK-------NEQLCQDIIDYQKQIDSQKETLLSRRGEDSDY---RSQLSKKNYE 214
+ L+++ ++L + + + +I +E +L ++S + + + + E
Sbjct: 951 HIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE 1010
Query: 215 LIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQL 274
L E + + KI + + M +LEE +++ EK E + K + D L
Sbjct: 1011 CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAK---RKLDGETTDL 1067
Query: 275 KKENDHYQLQVQELTDLLKSKNEE--------DDPIMVAVNA-KVEEWKLILSSKDDEII 325
+ + Q Q+ EL L K EE DD + NA KV ++ E
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDF 1127
Query: 326 EYQQMLHNLREKLK---NAQLDA------DKSNVMALQQGIQ-ERDSQIKMLTEQVEQYT 375
E ++ N EK K + +L+A D + A QQ ++ +R+ ++ L + +E+ T
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEET 1187
Query: 376 KEME--------KNTCIIEDLKNELQRNKGASTLSQQTHMKIQS-------TLDILKEKT 420
K E ++ +E+L +L++ K ++ +++ + +L++
Sbjct: 1188 KNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVK 1247
Query: 421 KEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIE 480
E+E + +A +E ++ E + + L++ E+ N ++ +++
Sbjct: 1248 AESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN---ELDNVSTLLEEAEKKGI 1304
Query: 481 ILTKEINKLELKISDFLD-ENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILL 539
K+ LE ++ D + E R+++ L + + L E +NS +Q++ + L
Sbjct: 1305 KFAKDAASLESQLQDTQELLQEETRQKLNLSSR-IRQLEEEKNSLQEQQEEEEEARKNLE 1363
Query: 540 KEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDLNLTENISQGDRISERKLDLLSL 599
K++ +L+ + D KKK+ + G + + L E +SQ R+ E+ L L
Sbjct: 1364 KQVLALQSQLADTKKKV---DDDLGTIESLEEAKKKLLKDAEALSQ--RLEEKALAYDKL 1418
Query: 600 KNMSEAQSKNEFLSRELIEKERDLERSRTV---IAKFQNKLKELVEENKQLEEGMKEILQ 656
+ ++KN L +EL + DL+ R V + K Q K +L+ E K + E
Sbjct: 1419 E-----KTKNR-LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAE--- 1469
Query: 657 AIKEMQKDPDVKGGETSLIIPSLER-LVNAIESKNAEGIFDASLHLKAQVDQLTGRNEEL 715
+ + + + + ET + SL R L A+E+K E + L+A ++ L +++
Sbjct: 1470 --ERDRAEAEAREKETKAL--SLARALEEALEAK--EEFERQNKQLRADMEDLMSSKDDV 1523
Query: 716 RQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSAS 775
+ + E K QQ+ + +++ LE E L+ +E + + + +
Sbjct: 1524 GKNVHELEKSKRALEQQVEEMRTQLEELEDE---LQATEDAKLRLE----------VNMQ 1570
Query: 776 IINSQNEYLIHLLQELENKEKK------LKNLEDSLEDYNRKFAVI---RHQQSLLYKEY 826
+ +Q E + E +N+EKK ++ LE LED ++ A+ + + + K+
Sbjct: 1571 AMKAQFERDLQTRDE-QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDL 1629
Query: 827 LSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKI 886
++ E + ++ RKL+ Q +K+Y L + DE+ E+ +K+
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQ-------MKDYQRELEEARASRDEIFAQSKESEKKL 1682
Query: 887 TVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKI 946
L E +++ L ER R+ E++++EL L K +I
Sbjct: 1683 KSL---EAEILQLQEELASSER-ARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738
Query: 947 AALQKVVDNSVSLSELELANKQYNELTAKYRDI---LQKDNMLVQRTSNL-EHLECENIS 1002
A L++ ++ S +EL N ++ + T + + L + Q++ N + LE +N
Sbjct: 1739 AQLEEELEE--EQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKE 1796
Query: 1003 LKEQVESI--------NKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVS 1054
LK +++ + + + K+ +E+ EQE K +++ N +
Sbjct: 1797 LKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK----------ERAAANKLVRR 1846
Query: 1055 ISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKV 1114
KK+ + M+ +ER+ A+ ++ E +KQ++ +LE E T+ N +K+
Sbjct: 1847 TEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKR---QLEEAEEEATRANASRRKL 1903
Query: 1115 EQMLRD--ELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQ 1172
++ L D E + +S+ VS KN + +S S RRQ+ + A
Sbjct: 1904 QRELDDATEANEGLSREVSTL---------KNRLRRGGPIS--FSSSRSGRRQLHLEGAS 1952
Query: 1173 QQSRDKEVESLRMQLLDYQAQSDE 1196
+ D + ES + + Q E
Sbjct: 1953 LELSDDDTESKTSDVNETQPPQSE 1976
Score = 147 bits (372), Expect = 1e-34
Identities = 267/1298 (20%), Positives = 534/1298 (41%), Gaps = 260/1298 (20%)
Query: 615 ELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEG---MKEILQAIKEMQKDPDVKGGE 671
EL K+ +L + + K + +L+E+ +++QL E + E LQA E+ + +
Sbjct: 853 ELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRAR 912
Query: 672 TSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQ 731
+ LE +++ +ES+ E + + L+ + ++ ++L ++L E
Sbjct: 913 LAAKKQELEEILHDLESR-VEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQL 971
Query: 732 QLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQEL 791
+ A KI +E+E LL + K + + D IA S+ +L
Sbjct: 972 EKVTAEAKIKKMEEEILLLEDQNSKFIKEKKL-MEDRIAECSS---------------QL 1015
Query: 792 ENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKT---IKEEKRKLE 848
+E+K KNL A IR++Q ++ + +E K E KT +++ KRKL+
Sbjct: 1016 AEEEEKAKNL-----------AKIRNKQEVMISDL---EERLKKEEKTRQELEKAKRKLD 1061
Query: 849 DQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKI----------TVLQVNEKSLIR 898
+ ++ E LQ DE+K LA+ ++ T+ + N ++R
Sbjct: 1062 GETTDLQDQIAE-------LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVR 1114
Query: 899 QYTTLV-------ELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQK 951
+ + E E+ R + EKQK +L E++ L+ E + AA Q+
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDL-------SEELEALKTELEDTLDTTAAQQE 1167
Query: 952 VVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESIN 1011
+ + E+ K E T + +Q +M + + LE L + EQ +
Sbjct: 1168 L--RTKREQEVAELKKALEEETKNHEAQIQ--DMRQRHATALEELSEQ----LEQAKRFK 1219
Query: 1012 KELEITKEKLHTIEQAWEQETK-LGNESSMDKAKKSITNSDIVSISKKITMLEMKELNER 1070
LE K+ L T + E K L + + K+ ++ + + K++ + +
Sbjct: 1220 ANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELA 1279
Query: 1071 QRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDE---LADSVS 1127
++A Q +++ T L++ E++ KFA+ DA +E L+D L +
Sbjct: 1280 EKASKLQNELDNVSTLLEEAEKKGI----KFAK------DAASLESQLQDTQELLQEETR 1329
Query: 1128 KAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQL 1187
+ ++ + R R LE EKN ++ + +E + AR+ +E K+V +L+ QL
Sbjct: 1330 QKLNLSSRIRQLEEEKNSLQ------EQQEEEEEARKNLE----------KQVLALQSQL 1373
Query: 1188 LDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQ 1247
D + + D+ LG +ES+ +K+ L Q+L+EK
Sbjct: 1374 ADTKKKVDDD--------------------LGTIESLEEAKKKLLKDAEALSQRLEEK-- 1411
Query: 1248 ALYYARLEG-RNRAKHLRQTIQSL------RRQFSGALPLAQQEKFSKTMIQLQNDKLKI 1300
AL Y +LE +NR L+Q + L +RQ + L +Q+KF + + + ++ +
Sbjct: 1412 ALAYDKLEKTKNR---LQQELDDLTVDLDHQRQVASNLE-KKQKKFDQLLAEEKSISARY 1467
Query: 1301 MQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELK 1360
+E ++ E R E K L + + LEE + ++ + K + M+
Sbjct: 1468 AEERDRAEAEAREKETKALSLA---RALEEALEAKEEFERQNKQLRADME---------- 1514
Query: 1361 LNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDI 1420
+L+ K+++ + E E++ +LE+++
Sbjct: 1515 ---DLMSSKDDV---GKNVHELEKSKRALEQQV--------------------------- 1541
Query: 1421 FDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEK 1480
E+ ++ E+ + D L +LE+ ++ +K L+TR +E+
Sbjct: 1542 -----EEMRTQLEELEDELQATEDAKL----RLEVNMQAMKAQFERDLQTR------DEQ 1586
Query: 1481 LKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQ 1540
+EK+ L + + + ++ +E + R A A ++K+ E+ K++E + K +
Sbjct: 1587 NEEKKRLLIKQVRELEA--ELEDERKQRALAVASKKKM--EIDLKDLEAQIEAANKARDE 1642
Query: 1541 TIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEE--------DLHILHHRLELQA 1592
I +L + + +K YQR LE+AR + EI + +E + IL + EL +
Sbjct: 1643 VIK----QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELAS 1698
Query: 1593 DSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLE 1652
+ + D + T + K + D L ++ ++ ++LE
Sbjct: 1699 SERARRHAEQERDELADEITNSASGKSALL------------DEKRRLEARIAQLEEELE 1746
Query: 1653 RQREITELKVKEFENIKLQLQE-NHEDEVKKVKAEVED-LKYLLDQSQKESQCLKSELQA 1710
++ EL F LQ+ N E ++ A+ D + L++ KE + EL+
Sbjct: 1747 EEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEG 1806
Query: 1711 QKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQK 1770
++ +A + + + +L+ QL + K++ AA +++ T +K
Sbjct: 1807 AVKSKFKATISALEAKIGQLEEQLEQEAKER----------------AAANKLVRRTEKK 1850
Query: 1771 EAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQ 1830
+E+ QVED + + KE ++ + R L L + E +
Sbjct: 1851 -------------LKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRAN 1897
Query: 1831 KAYNKILREKEEIDQENDELKRQIKRLTSGL-QGKPLT 1867
+ K+ RE ++ + N+ L R++ L + L +G P++
Sbjct: 1898 ASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPIS 1935
Score = 144 bits (364), Expect = 8e-34
Identities = 226/1057 (21%), Positives = 451/1057 (42%), Gaps = 139/1057 (13%)
Query: 1468 LETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAE------ 1521
++ + C+ + L+ + R+ + I R V+ L ER+ I +
Sbjct: 741 MDGKQACERMIRALELDPNLYRIGQSKIFFRAGVLAHLE------EERDLKITDIIIFFQ 794
Query: 1522 ------LGRKEMEPKSHH--TLKIAHQTIAN-MQARLNQKEEVLKKYQRLLEKAREEQRE 1572
L RK K LK+ + A ++ R Q V K + LL+ R+E+ E
Sbjct: 795 AVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEE-E 853
Query: 1573 IVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAE 1632
+ K EE L + + +++ + L + ++ L+++ LAE Q E
Sbjct: 854 LQAKDEELLKVKEKQTKVEGE--LEEMERKHQQLLEEKNI----------LAEQLQAETE 901
Query: 1633 QDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKY 1692
+ +L Q+LE E +V+E E LQ +E KK++A ++DL+
Sbjct: 902 LFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQ----NEKKKMQAHIQDLEE 957
Query: 1693 LLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELR 1752
LD+ + Q L+ E + + A M + L+ Q + K++K + + E
Sbjct: 958 QLDEEEGARQKLQLE-----KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 1753 AEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRE 1812
+++ E+ A + + + + + +R +E KT+ ++L + KL +++
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR-QELEKAKRKLDGETTDLQDQI 1071
Query: 1813 NSLTDNLNDLNNELQKKQKAYNKIL-REKEEIDQEND------ELKRQIKRLTSGLQGKP 1865
L +++L +L KK++ L R +E +N+ EL+ QI L + +
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131
Query: 1866 LTDNK-----QSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAKE-ELIRWEEGKKWQ 1919
+ NK + L EEL+ +LE+ L+ + +L+ +E+ E + EE K +
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191
Query: 1920 AKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRA 1979
A+I+ +R + E L++QL K A +K K L+ K V +
Sbjct: 1192 AQIQDMRQRHATALEE---LSEQLEQAKRFKANLEKNKQGLETDNKELACEV------KV 1242
Query: 1980 LESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLH----ALEKQ 2035
L+ K E K++ LD + L+ + + D + +L + LQ +L LE+
Sbjct: 1243 LQQVKAESEHKRKKLDAQVQELHAKVSEG---DRLRVELAEKASKLQNELDNVSTLLEEA 1299
Query: 2036 FSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRD 2095
K + +ES Q QEL +E + + + L ++ Q ++ L+ Q +
Sbjct: 1300 EKKGIKFAKDAASLESQ--LQDTQELLQEETR---QKLNLSSRIRQLEEEKNSLQEQQEE 1354
Query: 2096 LKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKAS 2155
+E + L+K+ +Q +L + K + + TI +++ +K+ ++ E L +
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTK------KKVDDDLGTIESLEEAKKKLLKDAEALSQR- 1407
Query: 2156 GILTSEKMA--NIEQENEKLKAELEKLKAHLGHQ--LSMHYESKTKGTEKIIAENERLRK 2211
L + +A +E+ +L+ EL+ L L HQ ++ + E K K ++++AE + +
Sbjct: 1408 --LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISA 1465
Query: 2212 ELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVV 2271
+E D AE E+ K L A + LE +
Sbjct: 1466 RYAEERDRAE----------------AEAREKETKALSLARALEEALEAKEE-------- 1501
Query: 2272 TRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGA 2331
+E + K+L D+ S D+ + V E + ++ + + E++ Q++ L+ +
Sbjct: 1502 ---FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558
Query: 2332 ETE--------QGLKRELQV-LRLANHQLDKEKAELIHQI---EANKDQSGAESTIPDAD 2379
E Q +K + + L+ + Q +++K LI Q+ EA + + + A
Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618
Query: 2380 QLKEKI--KDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEVKK 2437
+ K +I KDLE Q++ ++ + + ++++KL+ +++++ E+E+ + + E +
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ----RELEEARASRDEIFAQ 1674
Query: 2438 NILLEEKVKKLSE---QLGVELTSPVAASEEFEDEEE 2471
+ E+K+K L QL EL S A E E +
Sbjct: 1675 SKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1711
Score = 132 bits (331), Expect = 6e-30
Identities = 239/1160 (20%), Positives = 482/1160 (41%), Gaps = 144/1160 (12%)
Query: 462 VVEIKNCKNQIKIRDREI----EILTK---EINKLELKISDFLDENEALRERVGLEPKTM 514
++++ + +++ +D E+ E TK E+ ++E K L+E L E++ E +
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 515 IDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDL----KKKIRQMAQERGKRSATS 570
+ E R K+Q+ L +E EEER + KKK++ Q+ ++
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEE-EEERNQILQNEKKKMQAHIQDLEEQLDEE 962
Query: 571 GLTTEDLNLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELI----EKERDLERS 626
+ L L E ++ +I + + ++L L++ + K + L + I + + E
Sbjct: 963 EGARQKLQL-EKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 627 RTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLVNAI 686
+AK +NK + ++ + LEE +K+ + +E++K GET+
Sbjct: 1022 AKNLAKIRNKQEVMISD---LEERLKKEEKTRQELEKAKRKLDGETT------------- 1065
Query: 687 ESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKE 746
+ D L+AQ+D+L + + +EL+ + LA+ + + H
Sbjct: 1066 ------DLQDQIAELQAQIDELKLQLAKKEEELQGA----------LARGDDETLHKNNA 1109
Query: 747 TSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLE 806
++R+ + +L + AS N + L +ELE + + LED+L+
Sbjct: 1110 LKVVRELQAQIA-----ELQEDFESEKAS-RNKAEKQKRDLSEELEALKTE---LEDTLD 1160
Query: 807 DYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLN 866
QQ L K E K + K + +++D Q+ A ++E + L
Sbjct: 1161 -------TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQL- 1212
Query: 867 ALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEA 926
++ K+ A + L+ + K L + V++ +Q++ E+E ++ +L +
Sbjct: 1213 ------EQAKRFKANLEKNKQGLETDNKELACE----VKVLQQVKAESEHKRKKLDAQVQ 1262
Query: 927 EVCEKIGCLQRFKEMAIFKIAALQKVVDN-SVSLSELELANKQYNELTAKYRDILQKDNM 985
E+ K+ R + K + LQ +DN S L E E ++ + A LQ
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322
Query: 986 LVQR--------TSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETK---- 1033
L+Q +S + LE E SL+EQ E +E EK Q+ +TK
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE-EEEARKNLEKQVLALQSQLADTKKKVD 1381
Query: 1034 --LGNESSMDKAKKSITNSDIVSISKKI-------TMLEMKELNERQRAEHCQKMYEHLR 1084
LG S+++AKK + D ++S+++ LE + +Q + +H R
Sbjct: 1382 DDLGTIESLEEAKKKLL-KDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQR 1440
Query: 1085 TSLKQMEERNFELETKFAELTKINL------DAQKVEQMLRDELADSVSKAVSDADRQRI 1138
+E++ + + AE I+ D + E ++ A S+++A+ +A +
Sbjct: 1441 QVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAK- 1499
Query: 1139 LELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLL----DYQAQS 1194
E E+ +L+ ++ L D + V L +++ +++VE +R QL + QA
Sbjct: 1500 EEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE 1559
Query: 1195 DEK-----SLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQAL 1249
D K ++ A Q LQ + K + +++++EA E + + K++AL
Sbjct: 1560 DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEA-----ELEDERKQRAL 1614
Query: 1250 YYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQ 1309
A K + ++ L Q A +++ K + +LQ +E++ ++
Sbjct: 1615 AVA------SKKKMEIDLKDLEAQIEAA--NKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 1310 EHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDK 1369
+ ++ E E KLK LE I L++ + + H + E L + E+
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD-----EITNSA 1721
Query: 1370 EEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEIL 1429
L + E I+ LEEE+ ++ + + R Q+D + +
Sbjct: 1722 SGKSALLDEKRRLEARIAQLEEELEEE----QSNMELLNDRFRKTTLQVDTLNAELAAER 1777
Query: 1430 NAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILET-RATCKSLEEKLKEKESAL 1488
+AAQK + A + + L +L+ +K + + A LEE+L+++
Sbjct: 1778 SAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKER 1837
Query: 1489 RLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQAR 1548
A + + +K + E+ +++ E E+ A+ +++ME K++ +K + + +
Sbjct: 1838 AAANKLVRRTEKKLKEIFMQV----EDERRHADQYKEQME-KANARMKQLKRQLEEAEEE 1892
Query: 1549 LNQKEEVLKKYQRLLEKARE 1568
+ +K QR L+ A E
Sbjct: 1893 ATRANASRRKLQRELDDATE 1912
Score = 132 bits (331), Expect = 6e-30
Identities = 225/1124 (20%), Positives = 489/1124 (43%), Gaps = 138/1124 (12%)
Query: 207 QLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKN----------LEESVQEMEKMTDE 256
Q++++ EL +E+ + E K+E + +EM + L E +Q ++ E
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 257 YNRMKA-----------IVHQTDNVIDQ-------LKKENDHYQLQVQELTDLL------ 292
M+A I+H ++ +++ L+ E Q +Q+L + L
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 293 KSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHN-LREKLKNAQLDADKSNVM 351
+ K + + A K+EE L+L ++ + I+ ++++ + + E + +K+ +
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025
Query: 352 ALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMKIQS 411
A + QE ++ +E+ K+ EK +E K +L G +T Q ++Q+
Sbjct: 1026 AKIRNKQE------VMISDLEERLKKEEKTRQELEKAKRKLD---GETTDLQDQIAELQA 1076
Query: 412 TLDILKEKTKEAERTAELAEADAREKDKELVE--ALKRLKDYESGVYGLEDAVVEIKNCK 469
+D L K + A++ EL A AR D+ L + ALK +++ ++ + L++ K +
Sbjct: 1077 QIDEL--KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASR 1134
Query: 470 NQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQ 529
N+ + + R+ L++E+ L+ ++ D LD A +E L K ++ E + + + +
Sbjct: 1135 NKAEKQKRD---LSEELEALKTELEDTLDTTAAQQE---LRTKREQEVAELKKALEEETK 1188
Query: 530 QYRAENQ-ILLKEIESLEE--ERLDLKKKIRQMAQ--ERGKRSATSGLTTEDLNLTENIS 584
+ A+ Q + + +LEE E+L+ K+ + + ++G + L E + + + +
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACE-VKVLQQVK 1247
Query: 585 QGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEK----ERDLERSRTVIAKFQNK---- 636
+KLD ++ + S+ + L EL EK + +L+ T++ + + K
Sbjct: 1248 AESEHKRKKLD-AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306
Query: 637 -------------LKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLERLV 683
+EL++E + + + ++ ++E + + E +LE+ V
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366
Query: 684 NAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHL 743
A++S+ A+ K +VD G E L + ++ K+A SQ+L + L D L
Sbjct: 1367 LALQSQLAD--------TKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418
Query: 744 EKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLED 803
EK + L+Q V DL AS + + + LL E ++ + D
Sbjct: 1419 EKTKNRLQQELDDLTV----DLDH--QRQVASNLEKKQKKFDQLLAEEKSISARYAEERD 1472
Query: 804 SLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNN 863
E R+ + +E L KE ++ ++K ++ + L V E
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEK 1532
Query: 864 LLNALQMDSDEMKKILAENSRKITV-------LQVNEKSLIRQYTTLVELERQLRKENEK 916
AL+ +EM+ L E ++ L+VN +++ Q+ E + Q R E +
Sbjct: 1533 SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQF----ERDLQTRDEQNE 1588
Query: 917 QKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKV-VDNSVSLSELELANKQYNELTAK 975
+K LL + E L+ ++ +A+ +K+ +D +++E ANK +E+ +
Sbjct: 1589 EKKRLLIKQVRELE--AELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ 1646
Query: 976 YRDILQK----DNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQ----A 1027
R + + L + ++ + + ++ +++++S+ E+ +E+L + E+ A
Sbjct: 1647 LRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHA 1706
Query: 1028 WEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSL 1087
++ +L +E + + KS + + +I LE +EL E Q + + + + R +
Sbjct: 1707 EQERDELADEITNSASGKSALLDEKRRLEARIAQLE-EELEEEQ--SNMELLNDRFRKTT 1763
Query: 1088 KQMEERNFELETKFAELTKINLDAQKVEQMLRDELA--DSVSKAVSDADRQRILELEKNE 1145
Q++ N EL + + K + Q++E+ ++ A + AV + I LE
Sbjct: 1764 LQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALE--- 1820
Query: 1146 MELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDE-KSLIAKLH 1204
++ +L E + ++ N + +K+++ + MQ+ D + +D+ K + K +
Sbjct: 1821 ----AKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKAN 1876
Query: 1205 QHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQA 1248
L+ +LE + + A +L+++LD+ +A
Sbjct: 1877 ARMKQLK-------RQLEEAEEEATRANASRRKLQRELDDATEA 1913
Score = 124 bits (312), Expect = 9e-28
Identities = 164/756 (21%), Positives = 329/756 (43%), Gaps = 90/756 (11%)
Query: 36 EVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQ---LKTKVM 92
EV ELK +E + Q + + A +E E++E+A +A E L+T
Sbjct: 1175 EVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNK 1234
Query: 93 KLENELEMAQQ--SAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLAL 150
+L E+++ QQ + + L ++ +L ++ + DR ++ ++ K + + ++
Sbjct: 1235 ELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVST 1294
Query: 151 RNEEAENENSKLRRENKRLKKK---NEQLCQD-------IIDYQKQIDSQKETLLSRRGE 200
EEAE + K ++ L+ + ++L Q+ + +Q++ +K +L ++ E
Sbjct: 1295 LLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354
Query: 201 DSDYRSQLSKKNYELIQYLDE-----------IQTLTEANEKIEVQNQEMRKNLEESVQE 249
+ + R L K+ L L + I++L EA +K+ + + + LEE
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414
Query: 250 MEKMTDEYNRMKA--------IVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDP 301
+K+ NR++ + HQ + KK+ QL +E + + E D
Sbjct: 1415 YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERD-- 1472
Query: 302 IMVAVNAKVEEWK-LILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQER 360
A+ +E K L L+ +E +E ++ +N QL AD ++M+ + + +
Sbjct: 1473 -RAEAEAREKETKALSLARALEEALEAKEEFER-----QNKQLRADMEDLMSSKDDVGKN 1526
Query: 361 DSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQ--QTHMKIQSTLDILKE 418
+++ +EQ +EM +E+L++ELQ + A + MK Q D L+
Sbjct: 1527 VHELEKSKRALEQQVEEMRTQ---LEELEDELQATEDAKLRLEVNMQAMKAQFERD-LQT 1582
Query: 419 KTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDRE 478
+ ++ E L RE + EL + K V + +++K+ + QI+ ++
Sbjct: 1583 RDEQNEEKKRLLIKQVRELEAELED---ERKQRALAVASKKKMEIDLKDLEAQIEAANKA 1639
Query: 479 IEILTKEINKLELKISDF---LDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAEN 535
+ + K++ KL+ ++ D+ L+E A R+ + + K + K LK + AE
Sbjct: 1640 RDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSK--------ESEKKLKSLE--AEI 1689
Query: 536 QILLKEIESLEEERLDLKKKIRQMAQE-RGKRSATSGLTTEDLNLTENISQGDRISERKL 594
L +E+ S E R +++ ++A E S S L E L I+Q + E +
Sbjct: 1690 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749
Query: 595 DLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEI 654
+ L N + + L + + E ERS K N ++L +NK+L+ ++E+
Sbjct: 1750 SNMELLN---DRFRKTTLQVDTLNAELAAERS--AAQKSDNARQQLERQNKELKAKLQEL 1804
Query: 655 LQAIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNE- 713
A+K K I +LE + +E + + +A ++L R E
Sbjct: 1805 EGAVKSKFK----------ATISALEAKIGQLEEQ-----LEQEAKERAAANKLVRRTEK 1849
Query: 714 ---ELRQELRESRKEAINYSQQLAKANLKIDHLEKE 746
E+ ++ + R+ A Y +Q+ KAN ++ L+++
Sbjct: 1850 KLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQ 1885
Score = 88.6 bits (218), Expect = 7e-17
Identities = 83/401 (20%), Positives = 179/401 (44%), Gaps = 35/401 (8%)
Query: 34 KVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQAKFENQLKTKVMK 93
+ ++ EL+ E Q R+ ++ MKAQ E L+ ++ EE+ + L +V +
Sbjct: 1545 RTQLEELEDELQATEDAKLRLEVNMQAMKAQ-FERDLQTRDEQNEEKKRL---LIKQVRE 1600
Query: 94 LENELE--MAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKELEKEKKVNEQLALR 151
LE ELE Q++ + + ++ LE Q+E ++ +++ K+L K + +
Sbjct: 1601 LEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRE 1660
Query: 152 NEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKK 211
EEA ++ ++K +KK + L +I+ Q+++ S + E + +++
Sbjct: 1661 LEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720
Query: 212 NYELIQYLDEIQTLTEANEKIEVQNQEMRKNLE-------ESVQEMEKMTDEYNRMKAIV 264
LDE + L ++E + +E + N+E ++ +++ + E ++
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAA 1780
Query: 265 HQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEI 324
++DN QL+++N + ++QEL +KSK + + A+ AK+ + + L + E
Sbjct: 1781 QKSDNARQQLERQNKELKAKLQELEGAVKSKFKAT---ISALEAKIGQLEEQLEQEAKER 1837
Query: 325 IEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCI 384
+++ +KLK + Q++ +QY ++MEK
Sbjct: 1838 AAANKLVRRTEKKLKEIFM-------------------QVEDERRHADQYKEQMEKANAR 1878
Query: 385 IEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAER 425
++ LK +L+ + +T + + K+Q LD E + R
Sbjct: 1879 MKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSR 1919
Score = 85.9 bits (211), Expect = 5e-16
Identities = 93/427 (21%), Positives = 186/427 (43%), Gaps = 42/427 (9%)
Query: 34 KVEVNELKSEKQE--NVIHLFRITQSLMKMKAQEVELALEEVEKA--GEEQAKFENQLKT 89
+ ++ +L S K + +H ++ ++ + +E+ LEE+E E AK ++
Sbjct: 1510 RADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNM 1569
Query: 90 KVMKLENELEMAQQSAGGRDTRFLRNEICQLEKQLEQKDRELEDMEKE--LEKEKKVNEQ 147
+ MK + E ++ + + + L L KQ+ + + ELED K+ L K +
Sbjct: 1570 QAMKAQFERDLQTRDEQNEEKKRL------LIKQVRELEAELEDERKQRALAVASKKKME 1623
Query: 148 LALRNEEAENENSKLRREN--KRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYR 205
+ L++ EA+ E + R+ K+L+K Q+ DYQ++++ + + + +
Sbjct: 1624 IDLKDLEAQIEAANKARDEVIKQLRKLQAQMK----DYQRELEEARASRDEIFAQSKESE 1679
Query: 206 SQLSKKNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVH 265
+L E++Q +E+ + A E + E+ + S + DE R++A
Sbjct: 1680 KKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEAR-- 1737
Query: 266 QTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEII 325
I QL++E + Q ++ L D + + D + NA++ + D+
Sbjct: 1738 -----IAQLEEELEEEQSNMELLNDRFRKTTLQVDTL----NAELAAERSAAQKSDNARQ 1788
Query: 326 EYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCII 385
+ ++ L+ KL+ + A KS A I +++I L EQ+EQ KE ++
Sbjct: 1789 QLERQNKELKAKLQELE-GAVKSKFKAT---ISALEAKIGQLEEQLEQEAKERAAANKLV 1844
Query: 386 EDLKNELQR--------NKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREK 437
+ +L+ + A +Q K + + LK + +EAE A A A R+
Sbjct: 1845 RRTEKKLKEIFMQVEDERRHADQYKEQME-KANARMKQLKRQLEEAEEEATRANASRRKL 1903
Query: 438 DKELVEA 444
+EL +A
Sbjct: 1904 QRELDDA 1910
Score = 83.6 bits (205), Expect = 2e-15
Identities = 113/567 (19%), Positives = 226/567 (39%), Gaps = 84/567 (14%)
Query: 21 QEELADNLLISLSKVEVNELKSEKQENVIHLFRITQSLMKMKAQEVELALEEVEKAGEEQ 80
++ L +L S++ + K + I + + A+ + LEE A ++
Sbjct: 1359 RKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKL 1418
Query: 81 AKFENQLKTKVMKLENELEMAQQSAGGRDTRFLR-NEICQLEKQLEQKDRELEDMEKELE 139
K +N+L+ ++ L +L+ +Q A + + + +++ EK + + E D +
Sbjct: 1419 EKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEA 1478
Query: 140 KEKKVNE-QLALRNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRR 198
+EK+ LA EEA + R+NK+L+ E L D K + +++ +
Sbjct: 1479 REKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALE 1538
Query: 199 GEDSDYRSQLSKKNYEL------------------IQYLDEIQTLTEANEK--------- 231
+ + R+QL + EL Q+ ++QT E NE+
Sbjct: 1539 QQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQV 1598
Query: 232 --IEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELT 289
+E + ++ RK +V +KM + ++A + + D++ K+ Q Q+++
Sbjct: 1599 RELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1658
Query: 290 DLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADK-- 347
L+ D I A+ +E + L S + EI++ Q+ L + ++A+ + D+
Sbjct: 1659 RELEEARASRDEIF----AQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELA 1714
Query: 348 -------SNVMALQQGIQERDSQIKMLTEQVEQYTKEME-------KNTCIIEDLKNELQ 393
S AL + +++I L E++E+ ME K T ++ L EL
Sbjct: 1715 DEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELA 1774
Query: 394 RNKGASTLSQQTHMKIQSTLDILKEKTKEAE-------------------RTAELAEADA 434
+ A+ S +++ LK K +E E + E E +A
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEA 1834
Query: 435 REK----------DKELVEALKRLKDYESGV----YGLEDAVVEIKNCKNQIKIRDREIE 480
+E+ +K+L E +++D +E A +K K Q++ + E
Sbjct: 1835 KERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEAT 1894
Query: 481 ILTKEINKLELKISDFLDENEALRERV 507
KL+ ++ D + NE L V
Sbjct: 1895 RANASRRKLQRELDDATEANEGLSREV 1921
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.126 0.323
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,449,218
Number of Sequences: 37866
Number of extensions: 3775462
Number of successful extensions: 67254
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 522
Number of HSP's successfully gapped in prelim test: 1602
Number of HSP's that attempted gapping in prelim test: 20286
Number of HSP's gapped (non-prelim): 20792
length of query: 2479
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2360
effective length of database: 13,741,464
effective search space: 32429855040
effective search space used: 32429855040
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.