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Search of human proteins with 4557759
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557759 myeloperoxidase [Homo sapiens]
(745 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557759 myeloperoxidase [Homo sapiens] 1515 0.0
gi|4503595 eosinophil peroxidase [Homo sapiens] 1030 0.0
gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens] 736 0.0
gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens] 702 0.0
gi|28558982 thyroid peroxidase isoform a [Homo sapiens] 606 e-173
gi|28558988 thyroid peroxidase isoform d [Homo sapiens] 606 e-173
gi|28558984 thyroid peroxidase isoform b [Homo sapiens] 520 e-147
gi|109150416 peroxidasin [Homo sapiens] 510 e-144
gi|126517478 peroxidasin homolog-like [Homo sapiens] 438 e-123
gi|28558990 thyroid peroxidase isoform e [Homo sapiens] 292 9e-79
gi|20149640 dual oxidase 1 precursor [Homo sapiens] 124 3e-28
gi|28872751 dual oxidase 1 precursor [Homo sapiens] 124 3e-28
gi|132566532 dual oxidase 2 precursor [Homo sapiens] 115 2e-25
gi|4506265 prostaglandin-endoperoxide synthase 2 precursor [Homo... 45 2e-04
gi|18104967 prostaglandin-endoperoxide synthase 1 isoform 1 prec... 44 4e-04
gi|18104969 prostaglandin-endoperoxide synthase 1 isoform 2 prec... 42 0.002
gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [H... 31 4.8
gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens] 31 4.8
gi|14270487 protocadherin gamma subfamily A, 9 isoform 2 precurs... 31 4.8
>gi|4557759 myeloperoxidase [Homo sapiens]
Length = 745
Score = 1515 bits (3923), Expect = 0.0
Identities = 745/745 (100%), Positives = 745/745 (100%)
Query: 1 MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS 60
MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS
Sbjct: 1 MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTS 60
Query: 61 LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH 120
LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH
Sbjct: 61 LVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLH 120
Query: 121 VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC 180
VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC
Sbjct: 121 VALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMC 180
Query: 181 NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD 240
NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD
Sbjct: 181 NNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTD 240
Query: 241 QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND 300
QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND
Sbjct: 241 QLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPND 300
Query: 301 PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL 360
PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL
Sbjct: 301 PRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQL 360
Query: 361 GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL 420
GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL
Sbjct: 361 GLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLL 420
Query: 421 REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR 480
REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR
Sbjct: 421 REHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYR 480
Query: 481 SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE 540
SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE
Sbjct: 481 SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLE 540
Query: 541 GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN 600
GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN
Sbjct: 541 GGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYN 600
Query: 601 AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL 660
AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL
Sbjct: 601 AWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPL 660
Query: 661 LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS 720
LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS
Sbjct: 661 LACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMS 720
Query: 721 NSYPRDFVNCSTLPALNLASWREAS 745
NSYPRDFVNCSTLPALNLASWREAS
Sbjct: 721 NSYPRDFVNCSTLPALNLASWREAS 745
>gi|4503595 eosinophil peroxidase [Homo sapiens]
Length = 715
Score = 1030 bits (2663), Expect = 0.0
Identities = 501/716 (69%), Positives = 582/716 (81%), Gaps = 3/716 (0%)
Query: 27 MKLLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQ 86
M LL ALAG+LA L QP EG PA G V+TS++ + EAK LVD AY ++SIKQ
Sbjct: 1 MHLLPALAGVLATLVLAQPCEGTDPASPGAVETSVLRDCIAEAKLLVDAAYNWTQKSIKQ 60
Query: 87 RLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTP 146
RLRSGSASPM+LLSYFKQPVAATRT VRAADY+HVAL LLE KL+ PFNVTDVLT
Sbjct: 61 RLRSGSASPMDLLSYFKQPVAATRTVVRAADYMHVALGLLEEKLQPQRSGPFNVTDVLTE 120
Query: 147 AQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDG 206
QL +LS++SGCA +D C DKYRTITG CNN+R P LGASN+A RWLPAEYEDG
Sbjct: 121 PQLRLLSQASGCALRDQAERC--SDKYRTITGRCNNKRRPLLGASNQALARWLPAEYEDG 178
Query: 207 FSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFT 266
SLP+GWTP +RNGF + L RAVSN+IVRFP ++LT D+ R+LMFMQWGQ +DHDLDF+
Sbjct: 179 LSLPFGWTPSRRRNGFLLPLVRAVSNQIVRFPNERLTSDRGRALMFMQWGQFIDHDLDFS 238
Query: 267 PEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITI 326
PE AR +F GV+CE +C Q PPCFP+KIPPNDPRIKNQ DCIPFFRS P+CP + +
Sbjct: 239 PESPARVAFTAGVDCERTCAQLPPCFPIKIPPNDPRIKNQRDCIPFFRSAPSCPQNKNRV 298
Query: 327 RNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDP 386
RNQINALTSFVDASMVYGSE L+ LRN +N LGLLA+NQRFQDNGRALLPFDNLHDDP
Sbjct: 299 RNQINALTSFVDASMVYGSEVSLSLRLRNRTNYLGLLAINQRFQDNGRALLPFDNLHDDP 358
Query: 387 CLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEA 446
CLLTNRSARIPCFLAGDTRS+E P+L +MHTL +REHNRLATEL+ LNPRW+G++LY EA
Sbjct: 359 CLLTNRSARIPCFLAGDTRSTETPKLAAMHTLFMREHNRLATELRRLNPRWNGDKLYNEA 418
Query: 447 RKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQ 506
RKI+GAMVQIITYRD+LPLVLG R+ L YR Y +VDPR+ANVFT AFR+GHT++Q
Sbjct: 419 RKIMGAMVQIITYRDFLPLVLGKARARRTLGHYRGYCSNVDPRVANVFTLAFRFGHTMLQ 478
Query: 507 PFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVD 566
PFMFRLD++Y+ PN VPLS FFASWR+V EGGIDPILRGLMATPAKLNRQ+ + VD
Sbjct: 479 PFMFRLDSQYRASAPNSHVPLSSAFFASWRIVYEGGIDPILRGLMATPAKLNRQDAMLVD 538
Query: 567 EIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKL 626
E+R+RLF QV RIGLDL ALNMQRSRDHGLPGYNAWRRFCGL QP + QL VL+N L
Sbjct: 539 ELRDRLFRQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDL 598
Query: 627 ARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVF 686
ARK + YGTP+NIDIW+G ++EPL RVGPLLAC+ QFR+ RDGDRFWW+ GVF
Sbjct: 599 ARKFLNLYGTPDNIDIWIGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKRGVF 658
Query: 687 SMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWR 742
+ +QR+AL++ISL RIICDNTGITTVS+ +IF +N YPR FVNCS +P LNL++WR
Sbjct: 659 TKRQRKALSRISLSRIICDNTGITTVSR-DIFRANIYPRGFVNCSRIPRLNLSAWR 713
>gi|40549418 lactoperoxidase isoform 1 preproprotein [Homo sapiens]
Length = 712
Score = 736 bits (1900), Expect = 0.0
Identities = 371/720 (51%), Positives = 490/720 (68%), Gaps = 18/720 (2%)
Query: 27 MKLLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQ 86
M++LL L LLA L Q + A TS + ++ +AK V+KA+ + R +K
Sbjct: 1 MRVLLHLPALLASLILLQAAASTTRAQTTR--TSAISDTVSQAKVQVNKAFLDSRTRLKT 58
Query: 87 RLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTP 146
+ S + + +L Y K TRTA+R +L L +K ++T+V P
Sbjct: 59 AMSSETPTSRQLSEYLKHAKGRTRTAIRNGQVWEESLKRLRQKA--------SLTNVTDP 110
Query: 147 A-QLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYED 205
+ L LS GC V C YRTITG CNNRR P LGA+NRA RWLPAEYED
Sbjct: 111 SLDLTSLSLEVGCGAPAPVVRCDPCSPYRTITGDCNNRRKPALGAANRALARWLPAEYED 170
Query: 206 GFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDF 265
G SLP+GWTPG RNGFP+ LAR VSN+IV + ++ DQ RSL+FMQWGQ++DHDLDF
Sbjct: 171 GLSLPFGWTPGKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDF 230
Query: 266 TPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRS---CPACPGS 322
P+ +S + C+ C+Q CFP+ PPNDP+ Q C+PFFR+ CP P
Sbjct: 231 APDTELGSSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRAGFVCPTPPYK 290
Query: 323 NITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNL 382
++ R QINALTSF+DAS VY SE LA LRN+S+ LGL+AVNQ D+G LP+D+
Sbjct: 291 SLA-REQINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSK 349
Query: 383 HDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERL 442
PC N +AR+PCFLAGD+R+SE L + HTL LREHNRLA ELK LNP+WDGE+L
Sbjct: 350 KPSPCEFINTTARVPCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKL 409
Query: 443 YQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGH 502
YQEARKI+GA VQIIT+RDYLP++LG M+K++P Y+ Y++SVDPRI+NVFT AFR+GH
Sbjct: 410 YQEARKILGAFVQIITFRDYLPILLG-DHMQKWIPPYQGYSESVDPRISNVFTFAFRFGH 468
Query: 503 TLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQ 562
+ MFRLD YQP P P +PL +FF +WR+V +GGIDP++RGL+A +KL +QN+
Sbjct: 469 LEVPSSMFRLDENYQPWGPEPELPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNK 528
Query: 563 IAVDEIRERLFEQVMRI-GLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVL 621
+ E+R +LF+ RI G DL A+N QR RDHG PGYN+WR FC L QP+T+ +L TVL
Sbjct: 529 MMTGELRNKLFQPTHRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVL 588
Query: 622 RNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWE 681
++ LA+KL+ YGTP+NIDIW+G ++EPL +GRVGPLLAC++G QF+++RDGDRFWWE
Sbjct: 589 KSKMLAKKLLGLYGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWE 648
Query: 682 NEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASW 741
N GVF+ +Q+ +L ++S R++CDNT IT V ++ F +NSYP DFV+CS + L+L+ W
Sbjct: 649 NPGVFTNEQKDSLQKMSFSRLVCDNTRITKVPRDP-FWANSYPYDFVDCSAIDKLDLSPW 707
>gi|231569458 lactoperoxidase isoform 3 preproprotein [Homo sapiens]
Length = 629
Score = 702 bits (1812), Expect = 0.0
Identities = 337/597 (56%), Positives = 434/597 (72%), Gaps = 7/597 (1%)
Query: 149 LNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFS 208
L LS GC V C YRTITG CNNRR P LGA+NRA RWLPAEYEDG S
Sbjct: 31 LTSLSLEVGCGAPAPVVRCDPCSPYRTITGDCNNRRKPALGAANRALARWLPAEYEDGLS 90
Query: 209 LPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPE 268
LP+GWTPG RNGFP+ LAR VSN+IV + ++ DQ RSL+FMQWGQ++DHDLDF P+
Sbjct: 91 LPFGWTPGKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPD 150
Query: 269 PAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRS---CPACPGSNIT 325
+S + C+ C+Q CFP+ PPNDP+ Q C+PFFR+ CP P ++
Sbjct: 151 TELGSSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRAGFVCPTPPYKSLA 210
Query: 326 IRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDD 385
R QINALTSF+DAS VY SE LA LRN+S+ LGL+AVNQ D+G LP+D+
Sbjct: 211 -REQINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPS 269
Query: 386 PCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQE 445
PC N +AR+PCFLAGD+R+SE L + HTL LREHNRLA ELK LNP+WDGE+LYQE
Sbjct: 270 PCEFINTTARVPCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQE 329
Query: 446 ARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLI 505
ARKI+GA VQIIT+RDYLP++LG M+K++P Y+ Y++SVDPRI+NVFT AFR+GH +
Sbjct: 330 ARKILGAFVQIITFRDYLPILLG-DHMQKWIPPYQGYSESVDPRISNVFTFAFRFGHLEV 388
Query: 506 QPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAV 565
MFRLD YQP P P +PL +FF +WR+V +GGIDP++RGL+A +KL +QN++
Sbjct: 389 PSSMFRLDENYQPWGPEPELPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMT 448
Query: 566 DEIRERLFEQVMRI-GLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNL 624
E+R +LF+ RI G DL A+N QR RDHG PGYN+WR FC L QP+T+ +L TVL++
Sbjct: 449 GELRNKLFQPTHRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSK 508
Query: 625 KLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEG 684
LA+KL+ YGTP+NIDIW+G ++EPL +GRVGPLLAC++G QF+++RDGDRFWWEN G
Sbjct: 509 MLAKKLLGLYGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPG 568
Query: 685 VFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASW 741
VF+ +Q+ +L ++S R++CDNT IT V ++ F +NSYP DFV+CS + L+L+ W
Sbjct: 569 VFTNEQKDSLQKMSFSRLVCDNTRITKVPRDP-FWANSYPYDFVDCSAIDKLDLSPW 624
>gi|28558982 thyroid peroxidase isoform a [Homo sapiens]
Length = 933
Score = 606 bits (1562), Expect = e-173
Identities = 313/708 (44%), Positives = 437/708 (61%), Gaps = 24/708 (3%)
Query: 55 GEVDTSLVLSSMEEAKQLVDKA-YKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAV 113
G+ + S V S +EE+K+LVD A Y + ++K+R G SP +LLS+ K P +
Sbjct: 32 GKPEESRVSSVLEESKRLVDTAMYATMQRNLKKR---GILSPAQLLSFSKLPEPTSGVIA 88
Query: 114 RAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQ--- 170
RAA+ + ++ ++RK+ ++ + TD L+ L++++ SGC + CP
Sbjct: 89 RAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLA 148
Query: 171 DKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAV 230
+KYR ITG CNNR P GASN A RWLP YEDGFS P GW PG NGFP+ R V
Sbjct: 149 NKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREV 208
Query: 231 SNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPP 290
+ +++ + +T D S + M WGQ +DHD+ FTP+ ++A+F G +C+ +C Q P
Sbjct: 209 TRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNP 268
Query: 291 CFPLKIPPNDPRIKNQADCIPFFRSCPACPG----------SNITIRNQINALTSFVDAS 340
CFP+++P + R C+PF+RS AC S R Q+N LTSF+DAS
Sbjct: 269 CFPIQLP-EEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDAS 327
Query: 341 MVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRS----ARI 396
VYGS L R LRN ++ GLL V+ R +D+GRA LPF R
Sbjct: 328 TVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRG 387
Query: 397 PCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQI 456
PCFLAGD R+SE+P LT++HTL LREHNRLA LK+LN W + +YQEARK+VGA+ QI
Sbjct: 388 PCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQI 447
Query: 457 ITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDNR 515
IT RDY+P +LGP A ++Y+ Y Y+ + +P ++NVF T AFR+GH I P + RLD
Sbjct: 448 ITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS 507
Query: 516 YQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQ 575
+Q P + L + FF+ W ++ GG+DP++RGL+A PAKL Q+Q+ +E+ ERLF
Sbjct: 508 FQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVL 567
Query: 576 VMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYG 635
LDL ++N+QR RDHGLPGYN WR FCGLP+ ET L T + + +A K+++ Y
Sbjct: 568 SNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYK 627
Query: 636 TPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALA 695
P+NID+W+GG++E + R GPL AC+IG Q + LRDGD FWWEN VF+ QR+ L
Sbjct: 628 HPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELE 687
Query: 696 QISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWRE 743
+ SL R+ICDNTG+T V + F +P DF +C ++ +NL +WRE
Sbjct: 688 KHSLSRVICDNTGLTRVPM-DAFQVGKFPEDFESCDSITGMNLEAWRE 734
>gi|28558988 thyroid peroxidase isoform d [Homo sapiens]
Length = 889
Score = 606 bits (1562), Expect = e-173
Identities = 313/708 (44%), Positives = 437/708 (61%), Gaps = 24/708 (3%)
Query: 55 GEVDTSLVLSSMEEAKQLVDKA-YKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAV 113
G+ + S V S +EE+K+LVD A Y + ++K+R G SP +LLS+ K P +
Sbjct: 32 GKPEESRVSSVLEESKRLVDTAMYATMQRNLKKR---GILSPAQLLSFSKLPEPTSGVIA 88
Query: 114 RAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQ--- 170
RAA+ + ++ ++RK+ ++ + TD L+ L++++ SGC + CP
Sbjct: 89 RAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLA 148
Query: 171 DKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAV 230
+KYR ITG CNNR P GASN A RWLP YEDGFS P GW PG NGFP+ R V
Sbjct: 149 NKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREV 208
Query: 231 SNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPP 290
+ +++ + +T D S + M WGQ +DHD+ FTP+ ++A+F G +C+ +C Q P
Sbjct: 209 TRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNP 268
Query: 291 CFPLKIPPNDPRIKNQADCIPFFRSCPACPG----------SNITIRNQINALTSFVDAS 340
CFP+++P + R C+PF+RS AC S R Q+N LTSF+DAS
Sbjct: 269 CFPIQLP-EEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDAS 327
Query: 341 MVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRS----ARI 396
VYGS L R LRN ++ GLL V+ R +D+GRA LPF R
Sbjct: 328 TVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRG 387
Query: 397 PCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQI 456
PCFLAGD R+SE+P LT++HTL LREHNRLA LK+LN W + +YQEARK+VGA+ QI
Sbjct: 388 PCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQI 447
Query: 457 ITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDNR 515
IT RDY+P +LGP A ++Y+ Y Y+ + +P ++NVF T AFR+GH I P + RLD
Sbjct: 448 ITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS 507
Query: 516 YQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQ 575
+Q P + L + FF+ W ++ GG+DP++RGL+A PAKL Q+Q+ +E+ ERLF
Sbjct: 508 FQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVL 567
Query: 576 VMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYG 635
LDL ++N+QR RDHGLPGYN WR FCGLP+ ET L T + + +A K+++ Y
Sbjct: 568 SNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYK 627
Query: 636 TPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALA 695
P+NID+W+GG++E + R GPL AC+IG Q + LRDGD FWWEN VF+ QR+ L
Sbjct: 628 HPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELE 687
Query: 696 QISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWRE 743
+ SL R+ICDNTG+T V + F +P DF +C ++ +NL +WRE
Sbjct: 688 KHSLSRVICDNTGLTRVPM-DAFQVGKFPEDFESCDSITGMNLEAWRE 734
>gi|28558984 thyroid peroxidase isoform b [Homo sapiens]
Length = 876
Score = 520 bits (1340), Expect = e-147
Identities = 285/708 (40%), Positives = 397/708 (56%), Gaps = 81/708 (11%)
Query: 55 GEVDTSLVLSSMEEAKQLVDKA-YKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAV 113
G+ + S V S +EE+K+LVD A Y + ++K+R G SP +LLS+ K P +
Sbjct: 32 GKPEESRVSSVLEESKRLVDTAMYATMQRNLKKR---GILSPAQLLSFSKLPEPTSGVIA 88
Query: 114 RAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQ--- 170
RAA+ + ++ ++RK+ ++ + TD L+ L++++ SGC + CP
Sbjct: 89 RAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLA 148
Query: 171 DKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAV 230
+KYR ITG CNNR P GASN A RWLP YEDGFS P GW PG NGFP+ R V
Sbjct: 149 NKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREV 208
Query: 231 SNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPP 290
+ +++ + +T D S + M WGQ +DHD+ FTP+ ++A+F G +C+ +C Q P
Sbjct: 209 TRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNP 268
Query: 291 CFPLKIPPNDPRIKNQADCIPFFRSCPACPG----------SNITIRNQINALTSFVDAS 340
CFP+++P + R C+PF+RS AC S R Q+N LTSF+DAS
Sbjct: 269 CFPIQLP-EEARPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDAS 327
Query: 341 MVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRS----ARI 396
VYGS L R LRN ++ GLL V+ R +D+GRA LPF R
Sbjct: 328 TVYGSSPALERQLRNWTSAEGLLRVHARLRDSGRAYLPFVPPRAPAACAPEPGIPGETRG 387
Query: 397 PCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQI 456
PCFLAGD R+SE+P LT++HTL LREHNRLA LK+LN W + +YQEARK+VGA+ QI
Sbjct: 388 PCFLAGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQI 447
Query: 457 ITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDNR 515
IT RDY+P +LGP A ++Y+ Y Y+ + +P ++NVF T AFR+GH I P + RLD
Sbjct: 448 ITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLDAS 507
Query: 516 YQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQ 575
+Q P + L + FF+ W +LRG
Sbjct: 508 FQEHPDLPGLWLHQAFFSPWT---------LLRG-------------------------- 532
Query: 576 VMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYG 635
GYN WR FCGLP+ ET L T + + +A K+++ Y
Sbjct: 533 ----------------------GYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYK 570
Query: 636 TPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALA 695
P+NID+W+GG++E + R GPL AC+IG Q + LRDGD FWWEN VF+ QR+ L
Sbjct: 571 HPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRRELE 630
Query: 696 QISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWRE 743
+ SL R+ICDNTG+T V + F +P DF +C ++ +NL +WRE
Sbjct: 631 KHSLSRVICDNTGLTRVPM-DAFQVGKFPEDFESCDSITGMNLEAWRE 677
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 510 bits (1313), Expect = e-144
Identities = 296/750 (39%), Positives = 419/750 (55%), Gaps = 38/750 (5%)
Query: 14 DLGPCWAGGLTAEMKLLLALAGLLAILAT--PQPSEGAAPAVLGEVDTSLVLSSMEEAKQ 71
D+GP AG + + A + +L+ P S P V +S+ EA
Sbjct: 583 DVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDP---------FVATSIVEAIA 633
Query: 72 LVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAA-TRTAVRAADYLHVALDLLERKL 130
VD+A R + S SP +LL+ F+ P T RA + L L++ +
Sbjct: 634 TVDRAINSTRTHL---FDSRPRSPNDLLALFRYPRDPYTVEQARAGEIFERTLQLIQEHV 690
Query: 131 R-----SLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQ---DKYRTITGMCNN 182
+ L ++ D+++P LN+++ SGC C + KYRT G CNN
Sbjct: 691 QHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYRTHDGTCNN 750
Query: 183 RRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQL 242
+ P GAS AF R L + YE+GF+ P G P NG + + R VS ++ T+ +
Sbjct: 751 LQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTLIG--TETV 808
Query: 243 TPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPR 302
TPD++ + M MQWGQ LDHDLD T ++A F G +C C PPCF + IPPND R
Sbjct: 809 TPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPPCFSVMIPPNDSR 868
Query: 303 IKNQADCIPFFRSCPACPGSNITI--------RNQINALTSFVDASMVYGSEEPLARNLR 354
++ A C+ F RS P C GS +T R QIN LTS++DAS VYGS E AR++R
Sbjct: 869 ARSGARCMFFVRSSPVC-GSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTEHEARSIR 927
Query: 355 NMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTS 414
++++ GLL Q +G+ LLPF C+ + IPCFLAGD R++E LTS
Sbjct: 928 DLASHRGLLRQGI-VQRSGKPLLPFATGPPTECMRDENESPIPCFLAGDHRANEQLGLTS 986
Query: 415 MHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRK 474
MHTL REHNR+ATEL LNP WDG+ +Y E RKIVGA +Q ITY+ +LP +LG MR
Sbjct: 987 MHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLPKILGEVGMRT 1046
Query: 475 YLPTYRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFA 533
L Y Y+ ++ I N F T AFR+GHTL+ P ++RLD +QP+ + +PL + FF+
Sbjct: 1047 -LGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQD-HLPLHKAFFS 1104
Query: 534 SWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRD 593
+R+V EGGIDP+LRGL K+ +Q+ E+ ERLF + LDL A+N+QR RD
Sbjct: 1105 PFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAHTVALDLAAINIQRGRD 1164
Query: 594 HGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKR 653
HG+P Y+ +R +C L T L ++N ++ KL YG+ NID++ V E L
Sbjct: 1165 HGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGSTLNIDLFPALVVEDLVP 1224
Query: 654 KGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVS 713
R+GP L C++ TQF++LRDGDR W+EN GVFS Q + Q SL RI+CDN T
Sbjct: 1225 GSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLTQIKQTSLARILCDNADNITRV 1284
Query: 714 KNNIFMSNSYPRDFVNCSTLPALNLASWRE 743
++++F +P + +C +P ++L W++
Sbjct: 1285 QSDVFRVAEFPHGYGSCDEIPRVDLRVWQD 1314
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 438 bits (1127), Expect = e-123
Identities = 262/698 (37%), Positives = 370/698 (53%), Gaps = 26/698 (3%)
Query: 62 VLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHV 121
V SS+ +A Q VD A R + + S+ + Y + P+ RA +
Sbjct: 610 VESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMA--RAGEIFEH 667
Query: 122 ALDLLERKLRS-----LWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQ---DKY 173
L L+ +++ L + F D+++P L++++ SGC + C + KY
Sbjct: 668 TLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKY 727
Query: 174 RTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNE 233
R G CNN + PT GA+ AF R L Y DG P G V P+ R V+
Sbjct: 728 RAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQ-PLPPPRLVATV 786
Query: 234 IVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFP 293
R +TPD + M M WG L+HDLD T + A F G C + C PPCFP
Sbjct: 787 WARAAA--VTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFP 844
Query: 294 LKIPPNDPRIKNQADCIPFFRSCPACPGS-------NITIRNQINALTSFVDASMVYGSE 346
+ DPR A C+ F RS PAC ++ R QIN T+++D S VYGS
Sbjct: 845 MNTRHADPR-GTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSS 903
Query: 347 EPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRS 406
E ++ LR+ S GLL + +G+ LLPF C + + PCFLAGD R+
Sbjct: 904 ERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQES--PCFLAGDHRA 961
Query: 407 SEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLV 466
+E L +MHTL REHNR+ATEL +LNP W+G +YQEARKIVGA +Q ITY +LP V
Sbjct: 962 NEHLALAAMHTLWFREHNRVATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKV 1021
Query: 467 LGPTAMRKYLPTYRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDNRYQPMEPNPRV 525
LG R L YR YN +V+ I N F T AFR+GHTLI P ++RL+ + +
Sbjct: 1022 LGDPGTRM-LRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEG-HL 1079
Query: 526 PLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPA 585
P + F+ R++ EGGIDP+LRGL AK + + E+ +RLF +D A
Sbjct: 1080 PFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAA 1139
Query: 586 LNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMG 645
+QR RDHG+P Y +R FC L + L +++ ++ +KL + YG+P +ID+W
Sbjct: 1140 TIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPA 1199
Query: 646 GVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICD 705
+ E L RVGP L C+ TQF++LRDGDRFW+EN GVF+ Q L Q SL R++CD
Sbjct: 1200 LMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCD 1259
Query: 706 NTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWRE 743
N + ++F+ YP+D++NCS +P ++L W++
Sbjct: 1260 NGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQD 1297
>gi|28558990 thyroid peroxidase isoform e [Homo sapiens]
Length = 760
Score = 292 bits (747), Expect = 9e-79
Identities = 137/291 (47%), Positives = 194/291 (66%), Gaps = 2/291 (0%)
Query: 454 VQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRL 512
+QIIT RDY+P +LGP A ++Y+ Y Y+ + +P ++NVF T AFR+GH I P + RL
Sbjct: 272 IQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRL 331
Query: 513 DNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERL 572
D +Q P + L + FF+ W ++ GG+DP++RGL+A PAKL Q+Q+ +E+ ERL
Sbjct: 332 DASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERL 391
Query: 573 FEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLME 632
F LDL ++N+QR RDHGLPGYN WR FCGLP+ ET L T + + +A K+++
Sbjct: 392 FVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILD 451
Query: 633 QYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQ 692
Y P+NID+W+GG++E + R GPL AC+IG Q + LRDGD FWWEN VF+ QR+
Sbjct: 452 LYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSHVFTDAQRR 511
Query: 693 ALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWRE 743
L + SL R+ICDNTG+T V + F +P DF +C ++ +NL +WRE
Sbjct: 512 ELEKHSLSRVICDNTGLTRVPM-DAFQVGKFPEDFESCDSITGMNLEAWRE 561
Score = 189 bits (479), Expect = 1e-47
Identities = 97/246 (39%), Positives = 145/246 (58%), Gaps = 7/246 (2%)
Query: 55 GEVDTSLVLSSMEEAKQLVDKA-YKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAV 113
G+ + S V S +EE+K+LVD A Y + ++K+R G SP +LLS+ K P +
Sbjct: 32 GKPEESRVSSVLEESKRLVDTAMYATMQRNLKKR---GILSPAQLLSFSKLPEPTSGVIA 88
Query: 114 RAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQ--- 170
RAA+ + ++ ++RK+ ++ + TD L+ L++++ SGC + CP
Sbjct: 89 RAAEIMETSIQAMKRKVNLKTQQSQHPTDALSEDLLSIIANMSGCLPYMLPPKCPNTCLA 148
Query: 171 DKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAV 230
+KYR ITG CNNR P GASN A RWLP YEDGFS P GW PG NGFP+ R V
Sbjct: 149 NKYRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREV 208
Query: 231 SNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPP 290
+ +++ + +T D S + M WGQ +DHD+ FTP+ ++A+F G +C+ +C Q P
Sbjct: 209 TRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGADCQMTCENQNP 268
Query: 291 CFPLKI 296
CFP++I
Sbjct: 269 CFPIQI 274
>gi|20149640 dual oxidase 1 precursor [Homo sapiens]
Length = 1551
Score = 124 bits (311), Expect = 3e-28
Identities = 151/568 (26%), Positives = 242/568 (42%), Gaps = 64/568 (11%)
Query: 159 AYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVK 218
A+ +G P + + G NN G+ R +PA Y DG P G P +
Sbjct: 15 AWTPLGAQNPISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLG-EPHLP 73
Query: 219 RNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTG 278
R +SN I R P L + R+++ + +G + DL P A F+
Sbjct: 74 N-------PRDLSNTISRGPAG-LASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLN- 124
Query: 279 VNCETSCVQQPPCFPLKIPPNDPRIK--NQADCI-PFFRSC--PACPGSNITIRNQINAL 333
++IPP DP + D + PF RS P S R+ N +
Sbjct: 125 ---------------IRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQV 169
Query: 334 TSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRF-QDNGRALLPFDNLHDDPCLLTNR 392
T ++D S +YGS + LR+ S + F +D+ LL + DP N
Sbjct: 170 TGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMW--AAPDPATGQNG 227
Query: 393 SARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGA 452
+ F G R + P L ++ L R HN A L +P W+ E L+Q ARK V A
Sbjct: 228 PRGLYAF--GAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIA 285
Query: 453 MVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAF-RYGHTLIQP--FM 509
Q I ++L P+ ++K LP Y Y +DP I++ F A ++ T++ P +M
Sbjct: 286 TYQNIAVYEWL-----PSFLQKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYM 340
Query: 510 FRLDNRYQ-PMEPNPRVPLS-RVFFASW-----RVVLEGGIDPILRGLMATPAKLNRQNQ 562
+Q + N V + RV + W + +D +L G+ + A+ R++
Sbjct: 341 RNASCHFQGVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAE--REDH 398
Query: 563 IAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLR 622
+ V+++R+ + D A +QR RD GLP Y R GL + L
Sbjct: 399 VLVEDVRDFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALS 458
Query: 623 NLKLARKLMEQYGTPNNIDI-WM----GGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDR 677
+ ++E N D+ W+ GG+ E + GPL + I+ QF +LRDGDR
Sbjct: 459 --RSNDTVLEATAALYNQDLSWLELLPGGLLESHRDP---GPLFSTIVLEQFVRLRDGDR 513
Query: 678 FWWEN--EGVFSMQQRQALAQISLPRII 703
+W+EN G+FS ++ + + +L ++
Sbjct: 514 YWFENTRNGLFSKKEIEEIRNTTLQDVL 541
>gi|28872751 dual oxidase 1 precursor [Homo sapiens]
Length = 1551
Score = 124 bits (311), Expect = 3e-28
Identities = 151/568 (26%), Positives = 242/568 (42%), Gaps = 64/568 (11%)
Query: 159 AYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVK 218
A+ +G P + + G NN G+ R +PA Y DG P G P +
Sbjct: 15 AWTPLGAQNPISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLG-EPHLP 73
Query: 219 RNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTG 278
R +SN I R P L + R+++ + +G + DL P A F+
Sbjct: 74 N-------PRDLSNTISRGPAG-LASLRNRTVLGVFFGYHVLSDLVSVETPGCPAEFLN- 124
Query: 279 VNCETSCVQQPPCFPLKIPPNDPRIK--NQADCI-PFFRSC--PACPGSNITIRNQINAL 333
++IPP DP + D + PF RS P S R+ N +
Sbjct: 125 ---------------IRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQV 169
Query: 334 TSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRF-QDNGRALLPFDNLHDDPCLLTNR 392
T ++D S +YGS + LR+ S + F +D+ LL + DP N
Sbjct: 170 TGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMW--AAPDPATGQNG 227
Query: 393 SARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGA 452
+ F G R + P L ++ L R HN A L +P W+ E L+Q ARK V A
Sbjct: 228 PRGLYAF--GAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIA 285
Query: 453 MVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAF-RYGHTLIQP--FM 509
Q I ++L P+ ++K LP Y Y +DP I++ F A ++ T++ P +M
Sbjct: 286 TYQNIAVYEWL-----PSFLQKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYM 340
Query: 510 FRLDNRYQ-PMEPNPRVPLS-RVFFASW-----RVVLEGGIDPILRGLMATPAKLNRQNQ 562
+Q + N V + RV + W + +D +L G+ + A+ R++
Sbjct: 341 RNASCHFQGVINRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAE--REDH 398
Query: 563 IAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLR 622
+ V+++R+ + D A +QR RD GLP Y R GL + L
Sbjct: 399 VLVEDVRDFWPGPLKFSRTDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALS 458
Query: 623 NLKLARKLMEQYGTPNNIDI-WM----GGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDR 677
+ ++E N D+ W+ GG+ E + GPL + I+ QF +LRDGDR
Sbjct: 459 --RSNDTVLEATAALYNQDLSWLELLPGGLLESHRDP---GPLFSTIVLEQFVRLRDGDR 513
Query: 678 FWWEN--EGVFSMQQRQALAQISLPRII 703
+W+EN G+FS ++ + + +L ++
Sbjct: 514 YWFENTRNGLFSKKEIEEIRNTTLQDVL 541
>gi|132566532 dual oxidase 2 precursor [Homo sapiens]
Length = 1548
Score = 115 bits (287), Expect = 2e-25
Identities = 142/559 (25%), Positives = 232/559 (41%), Gaps = 87/559 (15%)
Query: 178 GMCNNRRSPTLGASNRAFVRWLPAEYEDGF--SLPYGWTPGVKRNGFPVALARAVSNEIV 235
G NN R GA R +PA Y DG +L P +R L+ A + I
Sbjct: 40 GWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRR------LSNAATRGIA 93
Query: 236 RFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLK 295
P+ R+++ + +G + D+ P A F+ ++
Sbjct: 94 GLPSLH-----NRTVLGVFFGYHVLSDVVSVETPGCPAEFLN----------------IR 132
Query: 296 IPPNDPRIK--NQADCI-PFFRSC--PACPGSNITIRNQINALTSFVDASMVYGSEEPLA 350
IPP DP + D + PF RS P S R+ N +T ++D S +YGS +
Sbjct: 133 IPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWS 192
Query: 351 RNLRNMSNQLGLLAVNQRF-QDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEM 409
LR+ S + F +D+ LL + DP N + F G R +
Sbjct: 193 DALRSFSGGQLASGPDPAFPRDSQNPLLMW--AAPDPATGQNGPRGLYAF--GAERGNRE 248
Query: 410 PELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGP 469
P L ++ L R HN A L +P W+ E L+Q ARK V A Q I ++L P
Sbjct: 249 PFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWL-----P 303
Query: 470 TAMRKYLPTYRSYNDSVDPRIANVFTNAF-RYGHTLIQPFMF------------------ 510
+ ++K LP Y Y +DP I+ F A ++ T++ P ++
Sbjct: 304 SFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQS 363
Query: 511 ----RLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVD 566
R+ N Y E NP + ++ ++ +L G+ + ++L ++ I V+
Sbjct: 364 SQALRVCNNYWIRE-NPNLNSTQ------------EVNELLLGMASQISEL--EDNIVVE 408
Query: 567 EIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKL 626
++R+ D A ++QR RD GLP Y+ GL P L + L
Sbjct: 409 DLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVL 468
Query: 627 ARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWEN--EG 684
+ +++ +GG+ L+ G GPL + I+ QF +LRDGDR+W+EN G
Sbjct: 469 EATAALYNQDLSQLELLLGGL---LESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNG 525
Query: 685 VFSMQQRQALAQISLPRII 703
+FS ++ + + +L ++
Sbjct: 526 LFSKKEIEDIRNTTLRDVL 544
>gi|4506265 prostaglandin-endoperoxide synthase 2 precursor [Homo
sapiens]
Length = 604
Score = 45.1 bits (105), Expect = 2e-04
Identities = 45/189 (23%), Positives = 77/189 (40%), Gaps = 25/189 (13%)
Query: 399 FLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKI-VGAMVQII 457
F G +P L T+ LREHNR+ LK +P W E+L+Q +R I +G ++I+
Sbjct: 271 FAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIV 330
Query: 458 TYRDYLPLVLGPTAMRKYLPTYR-SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRY 516
DY+ + G K+ P + RIA F + + L F D +Y
Sbjct: 331 -IEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIH-DQKY 388
Query: 517 QPMEPNPRVPLSRVFFASWRVVLEGGIDPILR-----------GLMATPAKLNRQNQIAV 565
+ F + ++LE GI + G P + + +Q ++
Sbjct: 389 NYQQ----------FIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASI 438
Query: 566 DEIRERLFE 574
D+ R+ ++
Sbjct: 439 DQSRQMKYQ 447
>gi|18104967 prostaglandin-endoperoxide synthase 1 isoform 1
precursor [Homo sapiens]
Length = 599
Score = 44.3 bits (103), Expect = 4e-04
Identities = 55/239 (23%), Positives = 111/239 (46%), Gaps = 29/239 (12%)
Query: 409 MPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKI-VGAMVQIITYRDYLPLVL 467
+P L TL LREHNR+ LK+ +P W E+L+Q R I +G ++I+ +Y+ +
Sbjct: 294 LPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIV-IEEYVQQLS 352
Query: 468 GPTAMRKYLPTYR-SYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVP 526
G K+ P RIA F + + + H L+ P F++ ++ E
Sbjct: 353 GYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHW-HPLM-PDSFKVGSQEYSYEQ----- 405
Query: 527 LSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPAL 586
F + ++++ G++ ++ +RQ + R + ++ + +D+
Sbjct: 406 ----FLFNTSMLVDYGVEALVDA-------FSRQIAGRIGGGR-NMDHHILHVAVDV--- 450
Query: 587 NMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMG 645
++ SR+ L +N +R+ G+ +P T Q ++ ++A +L E YG + ++ + G
Sbjct: 451 -IRESREMRLQPFNEYRKRFGM-KPYTSFQ--ELVGEKEMAAELEELYGDIDALEFYPG 505
>gi|18104969 prostaglandin-endoperoxide synthase 1 isoform 2
precursor [Homo sapiens]
Length = 562
Score = 42.0 bits (97), Expect = 0.002
Identities = 25/70 (35%), Positives = 39/70 (55%), Gaps = 2/70 (2%)
Query: 409 MPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKI-VGAMVQIITYRDYLPLVL 467
+P L TL LREHNR+ LK+ +P W E+L+Q R I +G ++I+ +Y+ +
Sbjct: 294 LPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIV-IEEYVQQLS 352
Query: 468 GPTAMRKYLP 477
G K+ P
Sbjct: 353 GYFLQLKFDP 362
>gi|4501915 ADAM metallopeptidase domain 9 isoform 1 precursor [Homo
sapiens]
Length = 819
Score = 30.8 bits (68), Expect = 4.8
Identities = 15/38 (39%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 283 TSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACP 320
T +QP FP + PP P++ +Q + IP R PA P
Sbjct: 777 TYAAKQPQQFPSRPPPPQPKVSSQGNLIP-ARPAPAPP 813
>gi|26080431 ATPase family, AAA domain containing 5 [Homo sapiens]
Length = 1844
Score = 30.8 bits (68), Expect = 4.8
Identities = 22/93 (23%), Positives = 41/93 (44%), Gaps = 4/93 (4%)
Query: 246 QERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKN 305
Q+++L+ + L D DLDF + + +S + N E S + N+P K
Sbjct: 1566 QKKTLVILDDSDLFDTDLDFPDQSISLSSVSSSSNAEESKTGDEES-KARDKGNNPETKK 1624
Query: 306 QADCIPFFRSCPACPGSNITIRNQINALTSFVD 338
C P + C + + + +N+L+ F+D
Sbjct: 1625 SIPCPPKTTAGKKC---SALVSHCLNSLSEFMD 1654
>gi|14270487 protocadherin gamma subfamily A, 9 isoform 2 precursor
[Homo sapiens]
Length = 828
Score = 30.8 bits (68), Expect = 4.8
Identities = 21/75 (28%), Positives = 38/75 (50%), Gaps = 10/75 (13%)
Query: 467 LGPTAMRKYLPTY-RSYNDSVDPRIANVFTNAFRYGHTLI--------QPFMFRLDNRYQ 517
+G +R +L TY + ++ + D R +++ Y TLI +P +D+++
Sbjct: 741 VGVDGVRAFLQTYSQEFSLTADSRKSHLIFPQPNYADTLISQQSCEKNEPLCVSVDSKF- 799
Query: 518 PMEPNPRVPLSRVFF 532
P+E P VP+S FF
Sbjct: 800 PIEDTPLVPVSSFFF 814
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,804,540
Number of Sequences: 37866
Number of extensions: 1309798
Number of successful extensions: 2816
Number of sequences better than 10.0: 19
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 2735
Number of HSP's gapped (non-prelim): 23
length of query: 745
length of database: 18,247,518
effective HSP length: 110
effective length of query: 635
effective length of database: 14,082,258
effective search space: 8942233830
effective search space used: 8942233830
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.