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Search of human proteins with 4557665
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557665 insulin-like growth factor 1 receptor precursor
[Homo sapiens]
(1367 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo... 2829 0.0
gi|119395738 insulin receptor isoform Short precursor [Homo sapi... 1581 0.0
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens] 1572 0.0
gi|31657140 insulin receptor-related receptor precursor [Homo sa... 1439 0.0
gi|29029632 anaplastic lymphoma kinase [Homo sapiens] 279 1e-74
gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens] 270 9e-72
gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precurs... 265 2e-70
gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precurs... 265 2e-70
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens] 247 5e-65
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo... 245 2e-64
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo... 245 2e-64
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo... 244 5e-64
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor... 244 5e-64
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo... 244 5e-64
gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens] 243 9e-64
gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens] 240 6e-63
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 237 7e-62
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 235 2e-61
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 235 2e-61
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 235 2e-61
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 235 2e-61
gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapi... 231 3e-60
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 230 6e-60
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 230 6e-60
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 230 6e-60
gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precur... 230 6e-60
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 228 4e-59
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 228 4e-59
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 228 4e-59
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 228 4e-59
>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
sapiens]
Length = 1367
Score = 2829 bits (7334), Expect = 0.0
Identities = 1367/1367 (100%), Positives = 1367/1367 (100%)
Query: 1 MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH 60
MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
Sbjct: 1 MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH 60
Query: 61 ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF 120
ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
Sbjct: 61 ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF 120
Query: 121 EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD 180
EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
Sbjct: 121 EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD 180
Query: 181 LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCS 240
LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCS
Sbjct: 181 LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCS 240
Query: 241 APDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHD 300
APDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHD
Sbjct: 241 APDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHD 300
Query: 301 GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL 360
GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
Sbjct: 301 GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL 360
Query: 361 LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSF 420
LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSF
Sbjct: 361 LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSF 420
Query: 421 YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR 480
YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
Sbjct: 421 YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR 480
Query: 481 NNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG 540
NNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
Sbjct: 481 NNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG 540
Query: 541 QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE 600
QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE
Sbjct: 541 QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE 600
Query: 601 ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRH 660
ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRH
Sbjct: 601 ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRH 660
Query: 661 NYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK 720
NYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
Sbjct: 661 NYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK 720
Query: 721 VFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFES 780
VFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFES
Sbjct: 721 VFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFES 780
Query: 781 RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW 840
RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW
Sbjct: 781 RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW 840
Query: 841 EPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN 900
EPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN
Sbjct: 841 EPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN 900
Query: 901 YTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHR 960
YTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHR
Sbjct: 901 YTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHR 960
Query: 961 KRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKG 1020
KRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKG
Sbjct: 961 KRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKG 1020
Query: 1021 VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIME 1080
VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIME
Sbjct: 1021 VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIME 1080
Query: 1081 LMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARN 1140
LMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARN
Sbjct: 1081 LMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARN 1140
Query: 1141 CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGV 1200
CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGV
Sbjct: 1141 CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGV 1200
Query: 1201 VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL 1260
VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL
Sbjct: 1201 VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL 1260
Query: 1261 EIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRH 1320
EIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRH
Sbjct: 1261 EIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRH 1320
Query: 1321 SGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC 1367
SGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
Sbjct: 1321 SGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC 1367
>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
Length = 1370
Score = 1581 bits (4094), Expect = 0.0
Identities = 794/1370 (57%), Positives = 1010/1370 (73%), Gaps = 43/1370 (3%)
Query: 17 LFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKA--EDYRSYR 74
L L AA L+P GE+C PG+DIRN+ +L LENC+VIEG+L ILL+ K ED+R
Sbjct: 21 LLLGAAGHLYP--GEVC-PGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS 77
Query: 75 FPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLR 134
FPKL +IT+YLLLFRV GLESL DLFPNLTVIRG +LF+NYALVIFEM +LK++GLYNL
Sbjct: 78 FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLM 137
Query: 135 NITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPP-KECGDLCPGTMEEKPMCE 193
NITRG++RIEKN +LCYL+T+DWS ILD+V +NYIV NK +ECGD+CPGT + K C
Sbjct: 138 NITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCP 197
Query: 194 KTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRH 253
T IN ++ RCWT + CQK+CP+ C CT CCH ECLG+CS PD+ T CVACR+
Sbjct: 198 ATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRN 257
Query: 254 YYYAGVCVPACPPNTYRFEGWRCVDRDFCANIL-SAESSDSEG---FVIHDGECMQECPS 309
+Y G CV CPP Y F+ WRCV+ FC ++ ++S +G +VIH+ +C+ ECPS
Sbjct: 258 FYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPS 317
Query: 310 GFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNN 369
G+ N S ++ C PC GPCPKVC + KTIDSVTSAQ L+GCT+ G+L+INIR GNN
Sbjct: 318 GYTMNSS-NLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNN 376
Query: 370 IASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQ 429
+A+ELE +GLIE ++GY+KIR S+ALVSLSF + LRLI GE GNYSFY LDNQNL+
Sbjct: 377 LAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLR 436
Query: 430 QLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCE 489
QLWDW NLTI GK++F +NPKLC+SEI++MEEV+GTKGRQ + DI + NG++ASCE
Sbjct: 437 QLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCE 496
Query: 490 SDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSW 549
+++L F+ TS ++I++ W Y PPD+RDL+ F ++YKEAP++NVTE+DGQDACGSNSW
Sbjct: 497 NELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSW 556
Query: 550 NMVDVDLP-----PNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYI 604
+VD+D P P PG L+ GLKPWTQYA++VK + +T + GAKS+I+Y+
Sbjct: 557 TVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTL-VTFSDERRTYGAKSDIIYV 615
Query: 605 RTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCS 664
+T+A+ PS+PLD +S SNSSSQ+I+KW PPS PNGN+++Y+V W+RQ +D L+ +YC
Sbjct: 616 QTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCL 675
Query: 665 KD-KIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFE 723
K K+P R ++ + E+ ++ ++E G CC+CPKT+++ E EE+ +RK FE
Sbjct: 676 KGLKLPSRTWSP-PFESEDSQKHNQSEY-EDSAGECCSCPKTDSQILKELEESSFRKTFE 733
Query: 724 NFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAA--DTYNITDPEELETEYPFFESR 781
++LHN +FVPRP RKRR + V N T++ T AA +T + + P E PF +
Sbjct: 734 DYLHNVVFVPRPSRKRRSLGDVGNVTVAVP---TVAAFPNTSSTSVPTSPEEHRPF--EK 788
Query: 782 VDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWE 841
V NKE VIS LR FT YRI++ +CN + + CS + +V ARTMP ADDI GPVT E
Sbjct: 789 VVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHE 848
Query: 842 PRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRE-CVSRQEYRKYGGAKLNRLNPGN 900
N + L W EP+ PNGLI++YE+ Y +++ CVSR+ + G +L L+PGN
Sbjct: 849 IFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGN 908
Query: 901 YTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHR 960
Y+ RI+ATSL+GNGSWT+P +FYV + I II P+ + + ++ +Y+F R
Sbjct: 909 YSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLR 968
Query: 961 KRNNSRLGNGVLYASVNPEYFSAADV-----YVPDEWEVAREKITMSRELGQGSFGMVYE 1015
KR G LYAS NPEY SA+DV YVPDEWEV+REKIT+ RELGQGSFGMVYE
Sbjct: 969 KRQPDG-PLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYE 1027
Query: 1016 GVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPT 1075
G A+ ++K E ETRVA+KTVNE+AS+RERIEFLNEASVMK F CHHVVRLLGVVS+GQPT
Sbjct: 1028 GNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPT 1087
Query: 1076 LVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRD 1135
LV+MELM GDLKSYLRSLRPE ENNP PP+L +MIQMA EIADGMAYLNA KFVHRD
Sbjct: 1088 LVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRD 1147
Query: 1136 LAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDV 1195
LAARNCMVA DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWM+PESLKDGVFTT SD+
Sbjct: 1148 LAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDM 1207
Query: 1196 WSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKM 1255
WSFGVVLWEI +LAEQPYQGLSNEQVL+FVM+GG LD+PDNCP+ + +LMRMCWQ+NPKM
Sbjct: 1208 WSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKM 1267
Query: 1256 RPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLP 1315
RP+FLEI++ +K+++ P F EVSF++SEENK PE EEL++E E+ME+VPLD S+
Sbjct: 1268 RPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQR-- 1325
Query: 1316 LPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSS 1365
+A G L + S++E PY HMNGG+KN R L LP+S+
Sbjct: 1326 -------EEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPRSN 1368
>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
Length = 1382
Score = 1572 bits (4071), Expect = 0.0
Identities = 794/1382 (57%), Positives = 1010/1382 (73%), Gaps = 55/1382 (3%)
Query: 17 LFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKA--EDYRSYR 74
L L AA L+P GE+C PG+DIRN+ +L LENC+VIEG+L ILL+ K ED+R
Sbjct: 21 LLLGAAGHLYP--GEVC-PGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS 77
Query: 75 FPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLR 134
FPKL +IT+YLLLFRV GLESL DLFPNLTVIRG +LF+NYALVIFEM +LK++GLYNL
Sbjct: 78 FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLM 137
Query: 135 NITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPP-KECGDLCPGTMEEKPMCE 193
NITRG++RIEKN +LCYL+T+DWS ILD+V +NYIV NK +ECGD+CPGT + K C
Sbjct: 138 NITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCP 197
Query: 194 KTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRH 253
T IN ++ RCWT + CQK+CP+ C CT CCH ECLG+CS PD+ T CVACR+
Sbjct: 198 ATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRN 257
Query: 254 YYYAGVCVPACPPNTYRFEGWRCVDRDFCANIL-SAESSDSEG---FVIHDGECMQECPS 309
+Y G CV CPP Y F+ WRCV+ FC ++ ++S +G +VIH+ +C+ ECPS
Sbjct: 258 FYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPS 317
Query: 310 GFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNN 369
G+ N S ++ C PC GPCPKVC + KTIDSVTSAQ L+GCT+ G+L+INIR GNN
Sbjct: 318 GYTMNSS-NLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNN 376
Query: 370 IASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQ 429
+A+ELE +GLIE ++GY+KIR S+ALVSLSF + LRLI GE GNYSFY LDNQNL+
Sbjct: 377 LAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLR 436
Query: 430 QLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCE 489
QLWDW NLTI GK++F +NPKLC+SEI++MEEV+GTKGRQ + DI + NG++ASCE
Sbjct: 437 QLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCE 496
Query: 490 SDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSW 549
+++L F+ TS ++I++ W Y PPD+RDL+ F ++YKEAP++NVTE+DGQDACGSNSW
Sbjct: 497 NELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSW 556
Query: 550 NMVDVDLP-----PNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYI 604
+VD+D P P PG L+ GLKPWTQYA++VK + +T + GAKS+I+Y+
Sbjct: 557 TVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTL-VTFSDERRTYGAKSDIIYV 615
Query: 605 RTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCS 664
+T+A+ PS+PLD +S SNSSSQ+I+KW PPS PNGN+++Y+V W+RQ +D L+ +YC
Sbjct: 616 QTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCL 675
Query: 665 KD-KIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFE 723
K K+P R ++ + E+ ++ ++E G CC+CPKT+++ E EE+ +RK FE
Sbjct: 676 KGLKLPSRTWSP-PFESEDSQKHNQSEY-EDSAGECCSCPKTDSQILKELEESSFRKTFE 733
Query: 724 NFLHNSIFVPR------------PERKRRDVMQVANTTMSSRSRNTTAA--DTYNITDPE 769
++LHN +FVPR P RKRR + V N T++ T AA +T + + P
Sbjct: 734 DYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVP---TVAAFPNTSSTSVPT 790
Query: 770 ELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAE 829
E PF +V NKE VIS LR FT YRI++ +CN + + CS + +V ARTMP
Sbjct: 791 SPEEHRPF--EKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEA 848
Query: 830 GADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRE-CVSRQEYRKY 888
ADDI GPVT E N + L W EP+ PNGLI++YE+ Y +++ CVSR+ +
Sbjct: 849 KADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALE 908
Query: 889 GGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIV 948
G +L L+PGNY+ RI+ATSL+GNGSWT+P +FYV + I II P+ + +
Sbjct: 909 RGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLF 968
Query: 949 GGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADV-----YVPDEWEVAREKITMSR 1003
++ +Y+F RKR G LYAS NPEY SA+DV YVPDEWEV+REKIT+ R
Sbjct: 969 SVVIGSIYLFLRKRQPDG-PLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLR 1027
Query: 1004 ELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVV 1063
ELGQGSFGMVYEG A+ ++K E ETRVA+KTVNE+AS+RERIEFLNEASVMK F CHHVV
Sbjct: 1028 ELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVV 1087
Query: 1064 RLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGM 1123
RLLGVVS+GQPTLV+MELM GDLKSYLRSLRPE ENNP PP+L +MIQMA EIADGM
Sbjct: 1088 RLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGM 1147
Query: 1124 AYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPES 1183
AYLNA KFVHRDLAARNCMVA DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWM+PES
Sbjct: 1148 AYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPES 1207
Query: 1184 LKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFE 1243
LKDGVFTT SD+WSFGVVLWEI +LAEQPYQGLSNEQVL+FVM+GG LD+PDNCP+ + +
Sbjct: 1208 LKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTD 1267
Query: 1244 LMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPEPEELDLEPENMESV 1303
LMRMCWQ+NPKMRP+FLEI++ +K+++ P F EVSF++SEENK PE EEL++E E+ME+V
Sbjct: 1268 LMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENV 1327
Query: 1304 PLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQ 1363
PLD S+ +A G L + S++E PY HMNGG+KN R L LP+
Sbjct: 1328 PLDRSSHCQR---------EEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILTLPR 1378
Query: 1364 SS 1365
S+
Sbjct: 1379 SN 1380
>gi|31657140 insulin receptor-related receptor precursor [Homo
sapiens]
Length = 1297
Score = 1439 bits (3726), Expect = 0.0
Identities = 729/1288 (56%), Positives = 927/1288 (71%), Gaps = 49/1288 (3%)
Query: 14 WG----LLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKA-- 67
WG ++FLS L + E+C P +DIR++ +L++LENC+V+EG+L ILL+ A
Sbjct: 9 WGACLPVIFLSLGFGL--DTVEVC-PSLDIRSEVAELRQLENCSVVEGHLQILLMFTATG 65
Query: 68 EDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKD 127
ED+R FP+LT +T+YLLLFRV GLESL DLFPNL VIRG +LF YALVIFEM +L+D
Sbjct: 66 EDFRGLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFLGYALVIFEMPHLRD 125
Query: 128 IGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTME 187
+ L L + RGA+R+EKN +LC+LST+DW L+ A N+IVGNK +EC D+CPG +
Sbjct: 126 VALPALGAVLRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLGEECADVCPGVLG 185
Query: 188 EK-PMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDT 246
C KTT + +YRCWT++ CQ++CP G ACT ECCH ECLG CS P++
Sbjct: 186 AAGEPCAKTTFSGHTDYRCWTSSHCQRVCPCPHGM-ACTARGECCHTECLGGCSQPEDPR 244
Query: 247 ACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQE 306
ACVACRH Y+ G C+ ACPP TY++E WRCV + CA++ S S F IH G C+ +
Sbjct: 245 ACVACRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPGRAST-FGIHQGSCLAQ 303
Query: 307 CPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRR 366
CPSGF RN S S++C CEG CPK C+ TKTIDS+ +AQ L GCT +G+L++N+R+
Sbjct: 304 CPSGFTRNSS-SIFCHKCEGLCPKECKVG--TKTIDSIQAAQDLVGCTHVEGSLILNLRQ 360
Query: 367 GNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQ 426
G N+ +L++ +GL+E +TG++KI+HS ALVSL F KNL+LI G+ ++GNY+ YVLDNQ
Sbjct: 361 GYNLEPQLQHSLGLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGNYTLYVLDNQ 420
Query: 427 NLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERA 486
NLQQL W LTI GK+YFAFNP+LC+ IYR+EEVTGT+GRQ+K +IN R NG+RA
Sbjct: 421 NLQQLGSWVAAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRA 480
Query: 487 SCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGS 546
+C++ L F S T +RI++ W RY P + RDL+SF VYYKE+PF+N TE+ G DACG+
Sbjct: 481 ACQTRTLRFVSNVTEADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGT 540
Query: 547 NSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRT 606
SWN++DV+LP ++ EPG+ L LKPWTQYAV+V+A+TLT E+ +GA+S I+Y+RT
Sbjct: 541 QSWNLLDVELPLSRTQEPGVTLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRT 600
Query: 607 NASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKD 666
+ P++P DV+S SNSSS L+V+W PP+ NGNL+YY+V WQR +DG LY ++YC +
Sbjct: 601 LPAAPTVPQDVISTSNSSSHLLVRWKPPTQRNGNLTYYLVLWQRLAEDGDLYLNDYCHRG 660
Query: 667 KIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCAC---PKTEAEKQAEKEEAEYRKVFE 723
D D E+ +P+ E+ + CC C P + E +EA ++K FE
Sbjct: 661 LRLPTSNNDPRFDGED--GDPEAEM----ESDCCPCQHPPPGQVLPPLEAQEASFQKKFE 714
Query: 724 NFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTY----NITDPEELETEYPFFE 779
NFLHN+I +P K V + + R+ AA N +D E E + P
Sbjct: 715 NFLHNAITIPISPWK---VTSINKSPQRDSGRHRRAAGPLRLGGNSSDFEIQEDKVP--- 768
Query: 780 SRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVT 839
+ER V+S LR FT YRIDIH+CNH A +GCSA+ FVFARTMP AD IPG V
Sbjct: 769 -----RERAVLSGLRHFTEYRIDIHACNHAAHTVGCSAATFVFARTMPHREADGIPGKVA 823
Query: 840 WEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRE-CVSRQEYRKYGGAKLNRLNP 898
WE +NS+ L+W EP +PNGLIL YEIKY E+ CVSR Y K+GG L L P
Sbjct: 824 WEASSKNSVLLRWLEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKFGGVHLALLPP 883
Query: 899 GNYTARIQATSLSGNGSWTDPVFFYVQAKTGYE-NFIHLII-ALPVAVLLIVGGLVIMLY 956
GNY+AR++ATSL+GNGSWTD V FY+ + +H+++ A PV + L++ L + +
Sbjct: 884 GNYSARVRATSLAGNGSWTDSVAFYILGPEEEDAGGLHVLLTATPVGLTLLIV-LAALGF 942
Query: 957 VFHRKRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEG 1016
+ +KRN + LYASVNPEYFSA+D+YVPDEWEV RE+I++ RELGQGSFGMVYEG
Sbjct: 943 FYGKKRNRT------LYASVNPEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEG 996
Query: 1017 VAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTL 1076
+A+G+ E T VA+KTVNE AS RE IEFL EASVMK F CHHVVRLLGVVSQGQPTL
Sbjct: 997 LARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTL 1056
Query: 1077 VIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDL 1136
VIMELMTRGDLKS+LRSLRPE ENNP L P+L +MIQMAGEIADGMAYL ANKFVHRDL
Sbjct: 1057 VIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDL 1116
Query: 1137 AARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVW 1196
AARNCMV++DFTVKIGDFGMTRD+YETDYYRKGGKGLLPVRWM+PESLKDG+FTT+SDVW
Sbjct: 1117 AARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVW 1176
Query: 1197 SFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMR 1256
SFGVVLWEI TLAEQPYQGLSNEQVL+FVM+GG+L++ + CP L ELM CWQ NP++R
Sbjct: 1177 SFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLR 1236
Query: 1257 PSFLEIISSIKEEMEPGFREVSFYYSEE 1284
PSF I+ SI+EE+ P FR +SFYYS E
Sbjct: 1237 PSFTHILDSIQEELRPSFRLLSFYYSPE 1264
>gi|29029632 anaplastic lymphoma kinase [Homo sapiens]
Length = 1620
Score = 279 bits (714), Expect = 1e-74
Identities = 162/442 (36%), Positives = 236/442 (53%), Gaps = 37/442 (8%)
Query: 939 ALPVAVLLIVGGLVIMLYVFHRKRNN---------------SRLGNGVLYASVNPEY-FS 982
AL A++L G++I V+ RK S+L + NP Y F+
Sbjct: 1043 ALVAALVLAFSGIMI---VYRRKHQELQAMQMELQSPEYKLSKLRTSTIMTDYNPNYCFA 1099
Query: 983 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMR 1042
+ D EV R+ IT+ R LG G+FG VYEG G+ D +VA+KT+ E S +
Sbjct: 1100 GKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQ 1159
Query: 1043 ERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNP 1102
+ ++FL EA ++ +FN ++VR +GV Q P +++ELM GDLKS+LR RP
Sbjct: 1160 DELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPS 1219
Query: 1103 VLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA---EDFTVKIGDFGMTRD 1159
LA + ++ +A +IA G YL N F+HRD+AARNC++ KIGDFGM RD
Sbjct: 1220 SLA---MLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARD 1276
Query: 1160 IYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNE 1219
IY YYRKGG +LPV+WM PE+ +G+FT+ +D WSFGV+LWEI +L PY SN+
Sbjct: 1277 IYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQ 1336
Query: 1220 QVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKE-EMEPGFREVS 1278
+VL FV GG +D P NCP ++ +M CWQ+ P+ RP+F I+ I+ +P +
Sbjct: 1337 EVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTA 1396
Query: 1279 FYYSEENKLPEPEELDLEPENMESVP----------LDPSASSSSLPLPDRHSGHKAENG 1328
+ E E++ + P++ E VP + + ++ PLP SG KA
Sbjct: 1397 LPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPTTSSG-KAAKK 1455
Query: 1329 PGPGVLVLRASFDERQPYAHMN 1350
P + +R H+N
Sbjct: 1456 PTAAEISVRVPRGPAVEGGHVN 1477
>gi|19924165 proto-oncogene c-ros-1 protein precursor [Homo sapiens]
Length = 2347
Score = 270 bits (689), Expect = 9e-72
Identities = 157/397 (39%), Positives = 222/397 (55%), Gaps = 47/397 (11%)
Query: 894 NRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVI 953
N L G Y+ + L G+ W F + G I L++ +P+
Sbjct: 1834 NNLGFGEYSGISENIILVGDDFWIPETSFILTIIVG----IFLVVTIPLT---------- 1879
Query: 954 MLYVFHRKRNNSRLGNGVLYASVNPEYFSA----------------ADVYVPDEWEVA-- 995
+V+HR+ N + + +N + A A +P + E+
Sbjct: 1880 --FVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENL 1937
Query: 996 ----REKITMSRELGQGSFGMVYEGVAKGVVK-DEPETRVAIKTVNEAASMRERIEFLNE 1050
REK+T+ LG G+FG VYEG A ++ E +VA+KT+ + ++ +E+IEFL E
Sbjct: 1938 PAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKE 1997
Query: 1051 ASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLS 1110
A +M +FN ++++ LGV +P +I+ELM GDL +YLR R P+L +L
Sbjct: 1998 AHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLL---TLV 2054
Query: 1111 KMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA-EDFT----VKIGDFGMTRDIYETDY 1165
++ + +I+ G YL F+HRDLAARNC+V+ +D+T VKIGDFG+ RDIY+ DY
Sbjct: 2055 DLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDY 2114
Query: 1166 YRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFV 1225
YRK G+GLLPVRWM+PESL DG+FTT SDVWSFG+++WEI TL QPY SN VL +V
Sbjct: 2115 YRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYV 2174
Query: 1226 MEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
GG L+ P NCPD L+ LM CW P RP+F I
Sbjct: 2175 QTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRI 2211
Score = 32.7 bits (73), Expect = 2.4
Identities = 29/129 (22%), Positives = 50/129 (38%), Gaps = 5/129 (3%)
Query: 564 PGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNS 623
P ++ L P+T+Y V + ++ + S + + PL S+S
Sbjct: 151 PSYVVKPLHPFTEYIFRVVWIFTAQLQ---LYSPPSPSYRTHPHGVPETAPLIRNIESSS 207
Query: 624 SSQLIVKWNPPSLPNGNLSYYIVRW--QRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIE 681
+ V W+PP P G + Y +R + Q D R ++ +P Y +
Sbjct: 208 PDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVN 267
Query: 682 EVTENPKTE 690
EV E P+ E
Sbjct: 268 EVGEGPEAE 276
Score = 32.3 bits (72), Expect = 3.2
Identities = 38/203 (18%), Positives = 77/203 (37%), Gaps = 24/203 (11%)
Query: 675 DGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPR 734
DG + +T T++ +KG + +A + + Y V + F +
Sbjct: 1391 DGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRS--RHILAYSSVMQPFPDKAFLSLA 1448
Query: 735 PERKRRDVMQVANTTMSSR-SRNTTAADTYNITDPEELETEYPFFESRVDNKERT----- 788
+ ++ NT+++ R T Y IT P Y + + V++++ +
Sbjct: 1449 SDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPT---YLVYYAEVNDRKNSSDLKY 1505
Query: 789 ----------VISNLRPFTLYRIDIHSCNHEAEKLG-CSASNFVFARTMPAEGADDIPGP 837
+I +L+PF+ Y I I N+ ++ L ++ +T G +
Sbjct: 1506 RILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTK--NGVPEAVQL 1563
Query: 838 VTWEPRPENSIFLKWPEPENPNG 860
+ R + S+ + W E PNG
Sbjct: 1564 INTTVRSDTSLIISWRESHKPNG 1586
>gi|42544153 leukocyte receptor tyrosine kinase isoform 1 precursor
[Homo sapiens]
Length = 864
Score = 265 bits (677), Expect = 2e-70
Identities = 145/385 (37%), Positives = 217/385 (56%), Gaps = 34/385 (8%)
Query: 965 SRLGNGVLYASVNPEYFSAADVYVPDEW-------EVAREKITMSRELGQGSFGMVYEGV 1017
S+L + + NP Y+ + W EV+ +T+ R LG G+FG VYEG+
Sbjct: 470 SKLRTSAIRTAPNP-YYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGL 528
Query: 1018 AKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV 1077
G+ D +VAIKT+ E S ++ ++FL EA ++ +F ++VR +G+ + P L+
Sbjct: 529 VIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLI 588
Query: 1078 IMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLA 1137
++ELM+ GD+KS+LR RP + +P + ++Q+A +IA G YL N F+HRD+A
Sbjct: 589 LLELMSGGDMKSFLRHSRPHLGQP---SPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIA 645
Query: 1138 ARNCMVA---EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSD 1194
ARNC+++ KIGDFGM RDIY YYR+G + LLPV+WM PE+ +G+FT+ +D
Sbjct: 646 ARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTD 705
Query: 1195 VWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPK 1254
WSFGV+LWEI +L PY G +N++VL FV+ GG +D P CP ++ +M CWQ+ P+
Sbjct: 706 SWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPE 765
Query: 1255 MRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPE-----------------PEELDLEP 1297
+RPSF I+ ++ + S E PE P+ +L P
Sbjct: 766 LRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSP 825
Query: 1298 ENMES---VPLDPSASSSSLPLPDR 1319
E ++S PL P SS PL R
Sbjct: 826 EKLKSWGGSPLGPWLSSGLKPLKSR 850
>gi|46249416 leukocyte receptor tyrosine kinase isoform 2 precursor
[Homo sapiens]
Length = 803
Score = 265 bits (677), Expect = 2e-70
Identities = 145/385 (37%), Positives = 217/385 (56%), Gaps = 34/385 (8%)
Query: 965 SRLGNGVLYASVNPEYFSAADVYVPDEW-------EVAREKITMSRELGQGSFGMVYEGV 1017
S+L + + NP Y+ + W EV+ +T+ R LG G+FG VYEG+
Sbjct: 409 SKLRTSAIRTAPNP-YYCQVGLGPAQSWPLPPGVTEVSPANVTLLRALGHGAFGEVYEGL 467
Query: 1018 AKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV 1077
G+ D +VAIKT+ E S ++ ++FL EA ++ +F ++VR +G+ + P L+
Sbjct: 468 VIGLPGDSSPLQVAIKTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLI 527
Query: 1078 IMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLA 1137
++ELM+ GD+KS+LR RP + +P + ++Q+A +IA G YL N F+HRD+A
Sbjct: 528 LLELMSGGDMKSFLRHSRPHLGQP---SPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIA 584
Query: 1138 ARNCMVA---EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSD 1194
ARNC+++ KIGDFGM RDIY YYR+G + LLPV+WM PE+ +G+FT+ +D
Sbjct: 585 ARNCLLSCAGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTD 644
Query: 1195 VWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPK 1254
WSFGV+LWEI +L PY G +N++VL FV+ GG +D P CP ++ +M CWQ+ P+
Sbjct: 645 SWSFGVLLWEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPE 704
Query: 1255 MRPSFLEIISSIKEEMEPGFREVSFYYSEENKLPE-----------------PEELDLEP 1297
+RPSF I+ ++ + S E PE P+ +L P
Sbjct: 705 LRPSFASILERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSP 764
Query: 1298 ENMES---VPLDPSASSSSLPLPDR 1319
E ++S PL P SS PL R
Sbjct: 765 EKLKSWGGSPLGPWLSSGLKPLKSR 789
>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
Length = 869
Score = 247 bits (631), Expect = 5e-65
Identities = 122/284 (42%), Positives = 179/284 (63%), Gaps = 14/284 (4%)
Query: 993 EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEAS 1052
E R I R++G+G+FG V++ A G++ EP T VA+K + E AS + +F EA+
Sbjct: 569 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 628
Query: 1053 VMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE--------------M 1098
+M EF+ ++V+LLGV + G+P ++ E M GDL +LRS+ P
Sbjct: 629 LMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQ 688
Query: 1099 ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTR 1158
++P P S ++ + +A ++A GMAYL+ KFVHRDLA RNC+V E+ VKI DFG++R
Sbjct: 689 VSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSR 748
Query: 1159 DIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSN 1218
+IY DYY+ +P+RWM PES+ +TT SDVW++GVVLWEI + QPY G+++
Sbjct: 749 NIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAH 808
Query: 1219 EQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
E+V+ +V +G +L P+NCP L+ LMR+CW P RPSF I
Sbjct: 809 EEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSI 852
>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform c
precursor [Homo sapiens]
Length = 822
Score = 245 bits (626), Expect = 2e-64
Identities = 127/289 (43%), Positives = 178/289 (61%), Gaps = 13/289 (4%)
Query: 977 NPEYFSAADVYV-PDEW--EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIK 1033
NP+YF + + PD + + R I + RELG+G+FG V+ + ++ + VA+K
Sbjct: 513 NPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVK 572
Query: 1034 TVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRS 1093
T+ +A+ R +F EA ++ H+V+ GV +G P +++ E M GDL +LR+
Sbjct: 573 TLKDASD-NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA 631
Query: 1094 LRPEM----ENNPVLAPPSL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDF 1147
P+ E NP P L S+M+ +A +IA GM YL + FVHRDLA RNC+V E+
Sbjct: 632 HGPDAVLMAEGNP---PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENL 688
Query: 1148 TVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIAT 1207
VKIGDFGM+RD+Y TDYYR GG +LP+RWM PES+ FTT SDVWS GVVLWEI T
Sbjct: 689 LVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFT 748
Query: 1208 LAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMR 1256
+QP+ LSN +V+ + +G +L +P CP ++ELM CWQ P MR
Sbjct: 749 YGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMR 797
>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform a
precursor [Homo sapiens]
Length = 838
Score = 245 bits (626), Expect = 2e-64
Identities = 127/289 (43%), Positives = 178/289 (61%), Gaps = 13/289 (4%)
Query: 977 NPEYFSAADVYV-PDEW--EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIK 1033
NP+YF + + PD + + R I + RELG+G+FG V+ + ++ + VA+K
Sbjct: 529 NPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVK 588
Query: 1034 TVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRS 1093
T+ +A+ R +F EA ++ H+V+ GV +G P +++ E M GDL +LR+
Sbjct: 589 TLKDASD-NARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRA 647
Query: 1094 LRPEM----ENNPVLAPPSL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDF 1147
P+ E NP P L S+M+ +A +IA GM YL + FVHRDLA RNC+V E+
Sbjct: 648 HGPDAVLMAEGNP---PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENL 704
Query: 1148 TVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIAT 1207
VKIGDFGM+RD+Y TDYYR GG +LP+RWM PES+ FTT SDVWS GVVLWEI T
Sbjct: 705 LVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFT 764
Query: 1208 LAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMR 1256
+QP+ LSN +V+ + +G +L +P CP ++ELM CWQ P MR
Sbjct: 765 YGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMR 813
>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform 1
[Homo sapiens]
Length = 790
Score = 244 bits (622), Expect = 5e-64
Identities = 124/291 (42%), Positives = 178/291 (61%), Gaps = 11/291 (3%)
Query: 977 NPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN 1036
NP+YFS A V+ + R I + ELG+G+FG V+ ++ ++ + VA+K +
Sbjct: 487 NPQYFSDACVH-----HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 541
Query: 1037 EAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP 1096
EA S R +F EA ++ H+VR GV ++G+P L++ E M GDL +LRS P
Sbjct: 542 EA-SESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 600
Query: 1097 EME-----NNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKI 1151
+ + + P L +++ +A ++A GM YL FVHRDLA RNC+V + VKI
Sbjct: 601 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 660
Query: 1152 GDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQ 1211
GDFGM+RDIY TDYYR GG+ +LP+RWM PES+ FTT SDVWSFGVVLWEI T +Q
Sbjct: 661 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 720
Query: 1212 PYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
P+ LSN + + + +G L++P CP ++ +MR CWQ P+ R S ++
Sbjct: 721 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 771
>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
[Homo sapiens]
Length = 796
Score = 244 bits (622), Expect = 5e-64
Identities = 124/291 (42%), Positives = 178/291 (61%), Gaps = 11/291 (3%)
Query: 977 NPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN 1036
NP+YFS A V+ + R I + ELG+G+FG V+ ++ ++ + VA+K +
Sbjct: 493 NPQYFSDACVH-----HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 547
Query: 1037 EAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP 1096
EA S R +F EA ++ H+VR GV ++G+P L++ E M GDL +LRS P
Sbjct: 548 EA-SESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 606
Query: 1097 EME-----NNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKI 1151
+ + + P L +++ +A ++A GM YL FVHRDLA RNC+V + VKI
Sbjct: 607 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 666
Query: 1152 GDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQ 1211
GDFGM+RDIY TDYYR GG+ +LP+RWM PES+ FTT SDVWSFGVVLWEI T +Q
Sbjct: 667 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 726
Query: 1212 PYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
P+ LSN + + + +G L++P CP ++ +MR CWQ P+ R S ++
Sbjct: 727 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 777
>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform 3
[Homo sapiens]
Length = 760
Score = 244 bits (622), Expect = 5e-64
Identities = 124/291 (42%), Positives = 178/291 (61%), Gaps = 11/291 (3%)
Query: 977 NPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN 1036
NP+YFS A V+ + R I + ELG+G+FG V+ ++ ++ + VA+K +
Sbjct: 457 NPQYFSDACVH-----HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK 511
Query: 1037 EAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRP 1096
EA S R +F EA ++ H+VR GV ++G+P L++ E M GDL +LRS P
Sbjct: 512 EA-SESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGP 570
Query: 1097 EME-----NNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKI 1151
+ + + P L +++ +A ++A GM YL FVHRDLA RNC+V + VKI
Sbjct: 571 DAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKI 630
Query: 1152 GDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQ 1211
GDFGM+RDIY TDYYR GG+ +LP+RWM PES+ FTT SDVWSFGVVLWEI T +Q
Sbjct: 631 GDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQ 690
Query: 1212 PYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
P+ LSN + + + +G L++P CP ++ +MR CWQ P+ R S ++
Sbjct: 691 PWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 741
>gi|21536466 AXL receptor tyrosine kinase isoform 1 [Homo sapiens]
Length = 894
Score = 243 bits (620), Expect = 9e-64
Identities = 171/539 (31%), Positives = 270/539 (50%), Gaps = 83/539 (15%)
Query: 790 ISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFART--MPAEGADDIP-GPVTWEPRPEN 846
+ +L P T Y I ++ C++S + T +P E + +P GP PEN
Sbjct: 296 LGSLHPHTPYHI----------RVACTSSQGPSSWTHWLPVETPEGVPLGP------PEN 339
Query: 847 --------SIFLKWPEPENP-NGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLN 897
F+ W EP P G +L Y + Y Q +D E + R+ +L
Sbjct: 340 ISATRNGSQAFVHWQEPRAPLQGTLLGYRLAY--QGQDTPEVLMDIGLRQEVTLELQGDG 397
Query: 898 P-GNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPV-------------- 942
N T + A + +G+G W+ PV + G +H ++ P
Sbjct: 398 SVSNLTVCVAAYTAAGDGPWSLPVPLEAW-RPGQAQPVHQLVKEPSTPAFSWPWWYVLLG 456
Query: 943 AVLLIVGGLVIMLYVFHRKRNNSRLGNG----------VLYASVNPEYFSAA------DV 986
AV+ L++ L++ HR++ +R G V+ V Y +
Sbjct: 457 AVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSL 516
Query: 987 YVPDEWE-------VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAA 1039
+ +E + V R K+ + + LG+G FG V EG +D+ +VA+KT+ A
Sbjct: 517 GISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSILKVAVKTMKIAI 573
Query: 1040 SMRERIE-FLNEASVMKEFNCHHVVRLLGVVSQGQPT------LVIMELMTRGDLKSYLR 1092
R +E FL+EA MKEF+ +V+RL+GV QG +VI+ M GDL S+L
Sbjct: 574 CTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFL- 632
Query: 1093 SLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIG 1152
L + + PV P + +++ +IA GM YL+ +F+HRDLAARNCM+ E+ +V +
Sbjct: 633 -LYSRLGDQPVYLPTQM--LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVA 689
Query: 1153 DFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP 1212
DFG+++ IY DYYR+G +PV+W++ ESL D V+T+ SDVWSFGV +WEIAT + P
Sbjct: 690 DFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTP 749
Query: 1213 YQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEME 1271
Y G+ N ++ ++ +G L +P +C D L+ LM CW+ NP+ RPSF E+ ++ ++
Sbjct: 750 YPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLK 808
>gi|21536468 AXL receptor tyrosine kinase isoform 2 [Homo sapiens]
Length = 885
Score = 240 bits (613), Expect = 6e-63
Identities = 168/532 (31%), Positives = 269/532 (50%), Gaps = 78/532 (14%)
Query: 790 ISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFART--MPAEGADDIP-GPVTWEPRPEN 846
+ +L P T Y I ++ C++S + T +P E + +P GP PEN
Sbjct: 296 LGSLHPHTPYHI----------RVACTSSQGPSSWTHWLPVETPEGVPLGP------PEN 339
Query: 847 --------SIFLKWPEPENP-NGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLN 897
F+ W EP P G +L Y + Y Q +D E + R+ +L
Sbjct: 340 ISATRNGSQAFVHWQEPRAPLQGTLLGYRLAY--QGQDTPEVLMDIGLRQEVTLELQGDG 397
Query: 898 P-GNYTARIQATSLSGNGSWTDPVFFYVQAKTGYEN-------FIHLIIALPVAVLLIVG 949
N T + A + +G+G W+ PV + + ++++ VA +
Sbjct: 398 SVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPVKEPSTPAFSWPWWYVLLGAVVAAACV-- 455
Query: 950 GLVIMLYVFHRKRNNSRLGNG----------VLYASVNPEYFSAA------DVYVPDEWE 993
L++ L++ HR++ +R G V+ V Y + + +E +
Sbjct: 456 -LILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELK 514
Query: 994 -------VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIE 1046
V R K+ + + LG+G FG V EG +D+ +VA+KT+ A R +E
Sbjct: 515 EKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLN---QDDSILKVAVKTMKIAICTRSELE 571
Query: 1047 -FLNEASVMKEFNCHHVVRLLGVVSQGQPT------LVIMELMTRGDLKSYLRSLRPEME 1099
FL+EA MKEF+ +V+RL+GV QG +VI+ M GDL S+L L +
Sbjct: 572 DFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFL--LYSRLG 629
Query: 1100 NNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRD 1159
+ PV P + +++ +IA GM YL+ +F+HRDLAARNCM+ E+ +V + DFG+++
Sbjct: 630 DQPVYLPTQM--LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKK 687
Query: 1160 IYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNE 1219
IY DYYR+G +PV+W++ ESL D V+T+ SDVWSFGV +WEIAT + PY G+ N
Sbjct: 688 IYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENS 747
Query: 1220 QVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEME 1271
++ ++ +G L +P +C D L+ LM CW+ NP+ RPSF E+ ++ ++
Sbjct: 748 EIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLK 799
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform b
precursor [Homo sapiens]
Length = 825
Score = 237 bits (604), Expect = 7e-62
Identities = 121/295 (41%), Positives = 179/295 (60%), Gaps = 10/295 (3%)
Query: 977 NPEYFSAA-DVYVPDEW--EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIK 1033
NP+YF + + PD + + R I + RELG+G+FG V+ + + + VA+K
Sbjct: 513 NPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVK 572
Query: 1034 TVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRS 1093
+ + ++ R +F EA ++ H+V+ GV G P +++ E M GDL +LR+
Sbjct: 573 ALKDP-TLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRA 631
Query: 1094 LRPE----MENNPVLAPPSL--SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDF 1147
P+ ++ P A L S+M+ +A +IA GM YL + FVHRDLA RNC+V +
Sbjct: 632 HGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANL 691
Query: 1148 TVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIAT 1207
VKIGDFGM+RD+Y TDYYR GG +LP+RWM PES+ FTT SDVWSFGV+LWEI T
Sbjct: 692 LVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFT 751
Query: 1208 LAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
+QP+ LSN +V+ + +G +L++P CP ++++M CWQ P+ R + EI
Sbjct: 752 YGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 806
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 235 bits (599), Expect = 2e-61
Identities = 121/306 (39%), Positives = 188/306 (61%), Gaps = 11/306 (3%)
Query: 972 LYASVNPEYFSAADVYVPDE--WEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPE-- 1027
L +S P ++ +P++ WE+ R+++ + + LG+G FG V A G+ KD+P
Sbjct: 358 LSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 417
Query: 1028 TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGD 1086
T+VA+K + A+ ++ + ++E +MK H +++ LLG +Q P VI+E ++G+
Sbjct: 418 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 477
Query: 1087 LKSYLRSLRP---EMENNPVLAPP---SLSKMIQMAGEIADGMAYLNANKFVHRDLAARN 1140
L+ YL++ RP E NP P S ++ A ++A GM YL + K +HRDLAARN
Sbjct: 478 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARN 537
Query: 1141 CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGV 1200
+V ED +KI DFG+ RDI+ DYY+K G LPV+WM+PE+L D ++T SDVWSFGV
Sbjct: 538 VLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGV 597
Query: 1201 VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL 1260
+LWEI TL PY G+ E++ + + EG +DKP NC + L+ +MR CW P RP+F
Sbjct: 598 LLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFK 657
Query: 1261 EIISSI 1266
+++ +
Sbjct: 658 QLVEDL 663
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 235 bits (599), Expect = 2e-61
Identities = 121/306 (39%), Positives = 188/306 (61%), Gaps = 11/306 (3%)
Query: 972 LYASVNPEYFSAADVYVPDE--WEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPE-- 1027
L +S P ++ +P++ WE+ R+++ + + LG+G FG V A G+ KD+P
Sbjct: 360 LSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 419
Query: 1028 TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGD 1086
T+VA+K + A+ ++ + ++E +MK H +++ LLG +Q P VI+E ++G+
Sbjct: 420 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 479
Query: 1087 LKSYLRSLRP---EMENNPVLAPP---SLSKMIQMAGEIADGMAYLNANKFVHRDLAARN 1140
L+ YL++ RP E NP P S ++ A ++A GM YL + K +HRDLAARN
Sbjct: 480 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARN 539
Query: 1141 CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGV 1200
+V ED +KI DFG+ RDI+ DYY+K G LPV+WM+PE+L D ++T SDVWSFGV
Sbjct: 540 VLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGV 599
Query: 1201 VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL 1260
+LWEI TL PY G+ E++ + + EG +DKP NC + L+ +MR CW P RP+F
Sbjct: 600 LLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFK 659
Query: 1261 EIISSI 1266
+++ +
Sbjct: 660 QLVEDL 665
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 235 bits (599), Expect = 2e-61
Identities = 121/306 (39%), Positives = 188/306 (61%), Gaps = 11/306 (3%)
Query: 972 LYASVNPEYFSAADVYVPDE--WEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPE-- 1027
L +S P ++ +P++ WE+ R+++ + + LG+G FG V A G+ KD+P
Sbjct: 447 LSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 506
Query: 1028 TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGD 1086
T+VA+K + A+ ++ + ++E +MK H +++ LLG +Q P VI+E ++G+
Sbjct: 507 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 566
Query: 1087 LKSYLRSLRP---EMENNPVLAPP---SLSKMIQMAGEIADGMAYLNANKFVHRDLAARN 1140
L+ YL++ RP E NP P S ++ A ++A GM YL + K +HRDLAARN
Sbjct: 567 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARN 626
Query: 1141 CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGV 1200
+V ED +KI DFG+ RDI+ DYY+K G LPV+WM+PE+L D ++T SDVWSFGV
Sbjct: 627 VLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGV 686
Query: 1201 VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL 1260
+LWEI TL PY G+ E++ + + EG +DKP NC + L+ +MR CW P RP+F
Sbjct: 687 LLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFK 746
Query: 1261 EIISSI 1266
+++ +
Sbjct: 747 QLVEDL 752
>gi|105990522 fibroblast growth factor receptor 1 isoform 1 precursor
[Homo sapiens]
Length = 822
Score = 235 bits (599), Expect = 2e-61
Identities = 121/306 (39%), Positives = 188/306 (61%), Gaps = 11/306 (3%)
Query: 972 LYASVNPEYFSAADVYVPDE--WEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPE-- 1027
L +S P ++ +P++ WE+ R+++ + + LG+G FG V A G+ KD+P
Sbjct: 449 LSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV 508
Query: 1028 TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGD 1086
T+VA+K + A+ ++ + ++E +MK H +++ LLG +Q P VI+E ++G+
Sbjct: 509 TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGN 568
Query: 1087 LKSYLRSLRP---EMENNPVLAPP---SLSKMIQMAGEIADGMAYLNANKFVHRDLAARN 1140
L+ YL++ RP E NP P S ++ A ++A GM YL + K +HRDLAARN
Sbjct: 569 LREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARN 628
Query: 1141 CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGV 1200
+V ED +KI DFG+ RDI+ DYY+K G LPV+WM+PE+L D ++T SDVWSFGV
Sbjct: 629 VLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGV 688
Query: 1201 VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL 1260
+LWEI TL PY G+ E++ + + EG +DKP NC + L+ +MR CW P RP+F
Sbjct: 689 LLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFK 748
Query: 1261 EIISSI 1266
+++ +
Sbjct: 749 QLVEDL 754
>gi|21361241 ephrin receptor EphA3 isoform a precursor [Homo sapiens]
Length = 983
Score = 231 bits (590), Expect = 3e-60
Identities = 165/526 (31%), Positives = 264/526 (50%), Gaps = 41/526 (7%)
Query: 763 YNITDPEELETEYPFFESRVDNKERTV-ISNLRPFTLYRIDIHSCNHEAEKLGCSASNFV 821
+NI E F + TV +++L T Y +I + N +E L F
Sbjct: 368 WNIKQCEPCSPNVRFLPRQFGLTNTTVTVTDLLAHTNYTFEIDAVNGVSE-LSSPPRQFA 426
Query: 822 FARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVS 881
+ A + + NSI L W EPE+PNG+IL YE+KY E Q + S
Sbjct: 427 AVSITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKY---YEKQEQETS 483
Query: 882 RQEYRKYG-GAKLNRLNPGN-YTARIQATSLSGNGS-------WTDPVFFYVQAKTGYEN 932
R G ++ L P Y +I+A + +G G+ T P F + ++
Sbjct: 484 YTILRARGTNVTISSLKPDTIYVFQIRARTAAGYGTNSRKFEFETSPDSFSISGESSQVV 543
Query: 933 FIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNS-----RLGNGVLYASVNPEYFSAADVY 987
I + A+ + +L +V ++I + ++ ++ + GNG L Y
Sbjct: 544 MIAISAAVAIILLTVVIYVLIGRFCGYKSKHGADEKRLHFGNGHLKLPGLRTYVDPHTYE 603
Query: 988 VPDE--WEVARE----KITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASM 1041
P + E A+E I++ + +G G FG V G K + + E VAIKT+ +
Sbjct: 604 DPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLK--LPSKKEISVAIKTLKVGYTE 661
Query: 1042 RERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENN 1101
++R +FL EAS+M +F+ +++RL GVV++ +P +++ E M G L S+LR +
Sbjct: 662 KQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQF--- 718
Query: 1102 PVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTR--- 1158
++ +++ M IA GM YL+ +VHRDLAARN ++ + K+ DFG++R
Sbjct: 719 ------TVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLE 772
Query: 1159 DIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSN 1218
D E Y +GGK +P+RW SPE++ FT+ SDVWS+G+VLWE+ + E+PY +SN
Sbjct: 773 DDPEAAYTTRGGK--IPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSN 830
Query: 1219 EQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIIS 1264
+ V++ V EG L P +CP L++LM CWQ + RP F +I+S
Sbjct: 831 QDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVS 876
Score = 31.2 bits (69), Expect = 7.1
Identities = 16/52 (30%), Positives = 26/52 (50%), Gaps = 1/52 (1%)
Query: 604 IRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNG-NLSYYIVRWQRQPQD 654
I TN + PS L + S + + + W P PNG L Y + +++Q Q+
Sbjct: 430 ITTNQAAPSPVLTIKKDRTSRNSISLSWQEPEHPNGIILDYEVKYYEKQEQE 481
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 230 bits (587), Expect = 6e-60
Identities = 121/320 (37%), Positives = 189/320 (59%), Gaps = 18/320 (5%)
Query: 962 RNNSRLGNGVLYASVNPEYFS---AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVA 1018
+++S L GV +S P + + D+ + WE R+++ + + LG+G FG V A
Sbjct: 387 KSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEA 446
Query: 1019 KGVVKDEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPT 1075
G+ P+ + VA+K + + AS ++ + ++E VMK H +++ LLGV +Q P
Sbjct: 447 FGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPL 506
Query: 1076 LVIMELMTRGDLKSYLRSLRPEMENNPVLAPP---------SLSKMIQMAGEIADGMAYL 1126
VI+E +G+L+ +LR+ RP P L+P S ++ A ++A GM YL
Sbjct: 507 YVIVECAAKGNLREFLRARRPP---GPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYL 563
Query: 1127 NANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKD 1186
+ K +HRDLAARN +V ED +KI DFG+ R ++ DYY+K G LPV+WM+PE+L D
Sbjct: 564 ESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFD 623
Query: 1187 GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMR 1246
V+T SDVWSFG++LWEI TL PY G+ E++ + EG +D+P +CP L+ LMR
Sbjct: 624 RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMR 683
Query: 1247 MCWQYNPKMRPSFLEIISSI 1266
CW P RP+F +++ ++
Sbjct: 684 ECWHAAPSQRPTFKQLVEAL 703
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 230 bits (587), Expect = 6e-60
Identities = 121/320 (37%), Positives = 189/320 (59%), Gaps = 18/320 (5%)
Query: 962 RNNSRLGNGVLYASVNPEYFS---AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVA 1018
+++S L GV +S P + + D+ + WE R+++ + + LG+G FG V A
Sbjct: 427 KSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEA 486
Query: 1019 KGVVKDEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPT 1075
G+ P+ + VA+K + + AS ++ + ++E VMK H +++ LLGV +Q P
Sbjct: 487 FGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPL 546
Query: 1076 LVIMELMTRGDLKSYLRSLRPEMENNPVLAPP---------SLSKMIQMAGEIADGMAYL 1126
VI+E +G+L+ +LR+ RP P L+P S ++ A ++A GM YL
Sbjct: 547 YVIVECAAKGNLREFLRARRPP---GPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYL 603
Query: 1127 NANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKD 1186
+ K +HRDLAARN +V ED +KI DFG+ R ++ DYY+K G LPV+WM+PE+L D
Sbjct: 604 ESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFD 663
Query: 1187 GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMR 1246
V+T SDVWSFG++LWEI TL PY G+ E++ + EG +D+P +CP L+ LMR
Sbjct: 664 RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMR 723
Query: 1247 MCWQYNPKMRPSFLEIISSI 1266
CW P RP+F +++ ++
Sbjct: 724 ECWHAAPSQRPTFKQLVEAL 743
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 230 bits (587), Expect = 6e-60
Identities = 121/320 (37%), Positives = 189/320 (59%), Gaps = 18/320 (5%)
Query: 962 RNNSRLGNGVLYASVNPEYFS---AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVA 1018
+++S L GV +S P + + D+ + WE R+++ + + LG+G FG V A
Sbjct: 427 KSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEA 486
Query: 1019 KGVVKDEPE--TRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPT 1075
G+ P+ + VA+K + + AS ++ + ++E VMK H +++ LLGV +Q P
Sbjct: 487 FGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPL 546
Query: 1076 LVIMELMTRGDLKSYLRSLRPEMENNPVLAPP---------SLSKMIQMAGEIADGMAYL 1126
VI+E +G+L+ +LR+ RP P L+P S ++ A ++A GM YL
Sbjct: 547 YVIVECAAKGNLREFLRARRPP---GPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYL 603
Query: 1127 NANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKD 1186
+ K +HRDLAARN +V ED +KI DFG+ R ++ DYY+K G LPV+WM+PE+L D
Sbjct: 604 ESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFD 663
Query: 1187 GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMR 1246
V+T SDVWSFG++LWEI TL PY G+ E++ + EG +D+P +CP L+ LMR
Sbjct: 664 RVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMR 723
Query: 1247 MCWQYNPKMRPSFLEIISSI 1266
CW P RP+F +++ ++
Sbjct: 724 ECWHAAPSQRPTFKQLVEAL 743
>gi|208879423 leukocyte receptor tyrosine kinase isoform 3 precursor
[Homo sapiens]
Length = 734
Score = 230 bits (587), Expect = 6e-60
Identities = 121/317 (38%), Positives = 183/317 (57%), Gaps = 26/317 (8%)
Query: 1026 PETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRG 1085
P + +T+ E S ++ ++FL EA ++ +F ++VR +G+ + P L+++ELM+ G
Sbjct: 407 PSQCYSAQTLPELCSPQDELDFLMEALIISKFRHQNIVRCVGLSLRATPRLILLELMSGG 466
Query: 1086 DLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVA- 1144
D+KS+LR RP + +P + ++Q+A +IA G YL N F+HRD+AARNC+++
Sbjct: 467 DMKSFLRHSRPHLGQP---SPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSC 523
Query: 1145 --EDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVL 1202
KIGDFGM RDIY YYR+G + LLPV+WM PE+ +G+FT+ +D WSFGV+L
Sbjct: 524 AGPSRVAKIGDFGMARDIYRASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLL 583
Query: 1203 WEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 1262
WEI +L PY G +N++VL FV+ GG +D P CP ++ +M CWQ+ P++RPSF I
Sbjct: 584 WEIFSLGYMPYPGRTNQEVLDFVVGGGRMDPPRGCPGPVYRIMTQCWQHEPELRPSFASI 643
Query: 1263 ISSIKEEMEPGFREVSFYYSEENKLPE-----------------PEELDLEPENMES--- 1302
+ ++ + S E PE P+ +L PE ++S
Sbjct: 644 LERLQYCTQDPDVLNSLLPMELGPTPEEEGTSGLGNRSLECLRPPQPQELSPEKLKSWGG 703
Query: 1303 VPLDPSASSSSLPLPDR 1319
PL P SS PL R
Sbjct: 704 SPLGPWLSSGLKPLKSR 720
>gi|222144244 fibroblast growth factor receptor 2 isoform 9 precursor
[Homo sapiens]
Length = 680
Score = 228 bits (580), Expect = 4e-59
Identities = 115/285 (40%), Positives = 176/285 (61%), Gaps = 9/285 (3%)
Query: 991 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPE--TRVAIKTVNEAASMRERIEFL 1048
+WE R+K+T+ + LG+G FG V A G+ KD+P+ VA+K + + A+ ++ + +
Sbjct: 385 KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV 444
Query: 1049 NEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE-ME-----NN 1101
+E +MK H +++ LLG +Q P VI+E ++G+L+ YLR+ RP ME N
Sbjct: 445 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINR 504
Query: 1102 PVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY 1161
+ ++ ++A GM YL + K +HRDLAARN +V E+ +KI DFG+ RDI
Sbjct: 505 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN 564
Query: 1162 ETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQV 1221
DYY+K G LPV+WM+PE+L D V+T SDVWSFGV++WEI TL PY G+ E++
Sbjct: 565 NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 624
Query: 1222 LRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI 1266
+ + EG +DKP NC + L+ +MR CW P RP+F +++ +
Sbjct: 625 FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 669
>gi|222144231 fibroblast growth factor receptor 2 isoform 3 precursor
[Homo sapiens]
Length = 769
Score = 228 bits (580), Expect = 4e-59
Identities = 115/285 (40%), Positives = 176/285 (61%), Gaps = 9/285 (3%)
Query: 991 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPE--TRVAIKTVNEAASMRERIEFL 1048
+WE R+K+T+ + LG+G FG V A G+ KD+P+ VA+K + + A+ ++ + +
Sbjct: 474 KWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLV 533
Query: 1049 NEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPE-ME-----NN 1101
+E +MK H +++ LLG +Q P VI+E ++G+L+ YLR+ RP ME N
Sbjct: 534 SEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINR 593
Query: 1102 PVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY 1161
+ ++ ++A GM YL + K +HRDLAARN +V E+ +KI DFG+ RDI
Sbjct: 594 VPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDIN 653
Query: 1162 ETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQV 1221
DYY+K G LPV+WM+PE+L D V+T SDVWSFGV++WEI TL PY G+ E++
Sbjct: 654 NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 713
Query: 1222 LRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSI 1266
+ + EG +DKP NC + L+ +MR CW P RP+F +++ +
Sbjct: 714 FKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 758
>gi|254028242 fibroblast growth factor receptor 3 isoform 3 precursor
[Homo sapiens]
Length = 808
Score = 228 bits (580), Expect = 4e-59
Identities = 118/307 (38%), Positives = 187/307 (60%), Gaps = 13/307 (4%)
Query: 972 LYASVNPEYFSAADVYVPDE--WEVAREKITMSRELGQGSFGMVYEGVAKGVVKD---EP 1026
L + P + +++ +P + WE++R ++T+ + LG+G FG V A G+ KD +P
Sbjct: 445 LSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKP 504
Query: 1027 ETRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRG 1085
T VA+K + + A+ ++ + ++E +MK H +++ LLG +QG P V++E +G
Sbjct: 505 VT-VAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKG 563
Query: 1086 DLKSYLRSLRPEMENNP--VLAPP----SLSKMIQMAGEIADGMAYLNANKFVHRDLAAR 1139
+L+ +LR+ RP + PP + ++ A ++A GM YL + K +HRDLAAR
Sbjct: 564 NLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAAR 623
Query: 1140 NCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFG 1199
N +V ED +KI DFG+ RD++ DYY+K G LPV+WM+PE+L D V+T SDVWSFG
Sbjct: 624 NVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 683
Query: 1200 VVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF 1259
V+LWEI TL PY G+ E++ + + EG +DKP NC L+ +MR CW P RP+F
Sbjct: 684 VLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTF 743
Query: 1260 LEIISSI 1266
+++ +
Sbjct: 744 KQLVEDL 750
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 228 bits (580), Expect = 4e-59
Identities = 118/307 (38%), Positives = 187/307 (60%), Gaps = 13/307 (4%)
Query: 972 LYASVNPEYFSAADVYVPDE--WEVAREKITMSRELGQGSFGMVYEGVAKGVVKD---EP 1026
L + P + +++ +P + WE++R ++T+ + LG+G FG V A G+ KD +P
Sbjct: 331 LSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKP 390
Query: 1027 ETRVAIKTVNEAASMRERIEFLNEASVMKEFNCH-HVVRLLGVVSQGQPTLVIMELMTRG 1085
T VA+K + + A+ ++ + ++E +MK H +++ LLG +QG P V++E +G
Sbjct: 391 VT-VAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKG 449
Query: 1086 DLKSYLRSLRPEMENNP--VLAPP----SLSKMIQMAGEIADGMAYLNANKFVHRDLAAR 1139
+L+ +LR+ RP + PP + ++ A ++A GM YL + K +HRDLAAR
Sbjct: 450 NLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAAR 509
Query: 1140 NCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFG 1199
N +V ED +KI DFG+ RD++ DYY+K G LPV+WM+PE+L D V+T SDVWSFG
Sbjct: 510 NVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 569
Query: 1200 VVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSF 1259
V+LWEI TL PY G+ E++ + + EG +DKP NC L+ +MR CW P RP+F
Sbjct: 570 VLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTF 629
Query: 1260 LEIISSI 1266
+++ +
Sbjct: 630 KQLVEDL 636
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,426,873
Number of Sequences: 37866
Number of extensions: 2762820
Number of successful extensions: 10776
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 506
Number of HSP's successfully gapped in prelim test: 437
Number of HSP's that attempted gapping in prelim test: 7551
Number of HSP's gapped (non-prelim): 2197
length of query: 1367
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1252
effective length of database: 13,892,928
effective search space: 17393945856
effective search space used: 17393945856
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.