Search of human proteins with 4557377

Search of human proteins with 4557377

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo
sapiens]
         (659 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]  1352   0.0  
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               714   0.0  
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]            649   0.0  
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]           649   0.0  
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                648   0.0  
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       571   e-163
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   340   2e-93
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   340   2e-93
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             331   1e-90
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               331   1e-90
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             331   1e-90
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             331   1e-90
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             331   1e-90
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...   329   6e-90
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...   329   6e-90
gi|4503787 fyn-related kinase [Homo sapiens]                          324   1e-88
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]     323   4e-88
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   322   9e-88
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...   322   9e-88
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       321   2e-87
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                 319   4e-87
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   318   8e-87
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   318   8e-87
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              318   1e-86
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      315   8e-86
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   310   4e-84
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   310   4e-84
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...   310   4e-84
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     271   2e-72
gi|4758078 c-src tyrosine kinase [Homo sapiens]                       271   2e-72

>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score = 1352 bits (3498), Expect = 0.0
 Identities = 659/659 (100%), Positives = 659/659 (100%)

Query: 1   MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK 60
           MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
Sbjct: 1   MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK 60

Query: 61  ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL 120
           ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
Sbjct: 61  ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL 120

Query: 121 RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS 180
           RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
Sbjct: 121 RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS 180

Query: 181 HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE 240
           HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
Sbjct: 181 HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE 240

Query: 241 YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK 300
           YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK
Sbjct: 241 YFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGK 300

Query: 301 EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN 360
           EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN
Sbjct: 301 EGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELIN 360

Query: 361 YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK 420
           YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK
Sbjct: 361 YHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGK 420

Query: 421 WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG 480
           WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG
Sbjct: 421 WRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANG 480

Query: 481 CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF 540
           CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF
Sbjct: 481 CLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDF 540

Query: 541 GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER 600
           GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER
Sbjct: 541 GLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYER 600

Query: 601 FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES 659
           FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
Sbjct: 601 FTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES 659


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  714 bits (1843), Expect = 0.0
 Identities = 354/657 (53%), Positives = 468/657 (71%), Gaps = 39/657 (5%)

Query: 5   ILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCV 64
           ILE I +KRSQQKKKTSPLN+K+RLF+LT   L+YYE    R  +  +KG IDV KI CV
Sbjct: 6   ILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYE---GRAEKKYRKGFIDVSKIKCV 62

Query: 65  ETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRW 124
           E V   KN   +  IP + +               YPFQVV+D   LY+F+P+ + R  W
Sbjct: 63  EIV---KND--DGVIPCQNK---------------YPFQVVHDANTLYIFAPSPQSRDLW 102

Query: 125 IHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKT 184
           + +LK  I+ N++++ KYHP FW DG Y CC QT K A GC+       S++        
Sbjct: 103 VKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIR-------- 154

Query: 185 KKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFIL 244
            K LPP PE  +  ++P PP P     ++ E+  VVA+YD+     +DL+L +G EY IL
Sbjct: 155 -KALPPAPETKK--RRPPPPIPLEEEDNSEEI--VVAMYDFQAAEGHDLRLERGQEYLIL 209

Query: 245 EESNLPWWRARDKNGQEGYIPSNYVT-EAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGG 303
           E++++ WWRARDK G EGYIPSNYVT +  ++++ YEWY ++M RS+AEQLL+ E KEGG
Sbjct: 210 EKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGG 269

Query: 304 FIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQS--QYYLAEKHLFSTIPELINY 361
           F+VRDSS+ G YTVS++ K  G+     RHY +  T  S  +YYLAEKH F +IPE+I Y
Sbjct: 270 FMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEY 329

Query: 362 HQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW 421
           H+HN+AGL++RL+YPVS + KNAP+TAG  Y  WEI+P +LTF++ELG+G FGVV+ GKW
Sbjct: 330 HKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKW 389

Query: 422 RGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGC 481
           R QY VAIK I+EG+M E++FIEEAKVMM L+H KLVQLYGVCT+Q+PI+I+TE+M  GC
Sbjct: 390 RAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGC 449

Query: 482 LLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFG 541
           LLN+LR+ +  F    LL MC+DVCE MEYLE   F+HRDLAARNCLV++ GVVKVSDFG
Sbjct: 450 LLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFG 509

Query: 542 LSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERF 601
           ++RYVLDD+YTSS G+KFPV+W PPEV  YS+FSSKSD+W+FGVLMWE+++ G+MP+E++
Sbjct: 510 MARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKY 569

Query: 602 TNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEE 658
           TN E    + +G RLY+P LAS  VY +M  CW EK + RP+F+ LL  I ++++ E
Sbjct: 570 TNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECE 626


>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  649 bits (1673), Expect = 0.0
 Identities = 335/693 (48%), Positives = 454/693 (65%), Gaps = 64/693 (9%)

Query: 5   ILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCV 64
           ILE + LKRSQQKKK SP N+K+RLF+LT   LSYYEYD  + +RGS+KGSI+++KI CV
Sbjct: 6   ILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYD--KMKRGSRKGSIEIKKIRCV 63

Query: 65  ETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRW 124
           E V  E+  P ERQ                     YPFQ+VY +G LYV++  EE R +W
Sbjct: 64  EKVNLEEQTPVERQ---------------------YPFQIVYKDGLLYVYASNEESRSQW 102

Query: 125 IHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKT 184
           +  L+  IR N  L+ KYH  F++DG++LCC Q+ K A GC + E    +L    +  K 
Sbjct: 103 LKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWE-AYANLHTAVNEEKH 161

Query: 185 KKPLPPT-----PEEDQILKKPLPPEPAAAPVSTSELKK-----------VVALYDYMPM 228
           + P  P      P    +LK   P          +E KK            +A YD    
Sbjct: 162 RVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSK 221

Query: 229 NANDLQLRKGDEYFILEESNLPWWRAR------------DKNGQEGYI-----------P 265
                Q     +Y I  E    WW+ R              N +E  +           P
Sbjct: 222 KIYGSQPNFNMQY-IPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFP 280

Query: 266 SNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTG 325
            +  +E E++++ Y+W++ +++RSQ+EQLL+Q+GKEG F+VR+SS+ G YTVS+F+K+  
Sbjct: 281 ESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVN 340

Query: 326 DPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAP 385
           D +G ++HY V +  +++ YLAE + F +IP+LI+YHQHNSAG+I+RL++PVS +    P
Sbjct: 341 DKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVP 400

Query: 386 STAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEE 445
            +  LG G WE+  +++T LKELG+GQFGVV+ GKW+GQYDVA+KMIKEGSMSEDEF +E
Sbjct: 401 DSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQE 460

Query: 446 AKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDV 505
           A+ MM LSH KLV+ YGVC+K+ PI+I+TEY++NGCLLNYLR      +  QLLEMC DV
Sbjct: 461 AQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDV 520

Query: 506 CEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSP 565
           CE M +LES QF+HRDLAARNCLV+    VKVSDFG++RYVLDD+Y SSVG+KFPV+WS 
Sbjct: 521 CEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSA 580

Query: 566 PEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEK 625
           PEV  Y K+SSKSD+WAFG+LMWE++SLGK PY+ + NS+    ++QG RLYRPHLAS+ 
Sbjct: 581 PEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDT 640

Query: 626 VYTIMYSCWHEKADERPTFKILLSNILDVMDEE 658
           +Y IMYSCWHE  ++RPTF+ LLS+I  + +++
Sbjct: 641 IYQIMYSCWHELPEKRPTFQQLLSSIEPLREKD 673


>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  649 bits (1673), Expect = 0.0
 Identities = 335/693 (48%), Positives = 454/693 (65%), Gaps = 64/693 (9%)

Query: 5   ILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCV 64
           ILE + LKRSQQKKK SP N+K+RLF+LT   LSYYEYD  + +RGS+KGSI+++KI CV
Sbjct: 6   ILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYD--KMKRGSRKGSIEIKKIRCV 63

Query: 65  ETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRW 124
           E V  E+  P ERQ                     YPFQ+VY +G LYV++  EE R +W
Sbjct: 64  EKVNLEEQTPVERQ---------------------YPFQIVYKDGLLYVYASNEESRSQW 102

Query: 125 IHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKT 184
           +  L+  IR N  L+ KYH  F++DG++LCC Q+ K A GC + E    +L    +  K 
Sbjct: 103 LKALQKEIRGNPHLLVKYHSGFFVDGKFLCCQQSCKAAPGCTLWE-AYANLHTAVNEEKH 161

Query: 185 KKPLPPT-----PEEDQILKKPLPPEPAAAPVSTSELKK-----------VVALYDYMPM 228
           + P  P      P    +LK   P          +E KK            +A YD    
Sbjct: 162 RVPTFPDRVLKIPRAVPVLKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSK 221

Query: 229 NANDLQLRKGDEYFILEESNLPWWRAR------------DKNGQEGYI-----------P 265
                Q     +Y I  E    WW+ R              N +E  +           P
Sbjct: 222 KIYGSQPNFNMQY-IPREDFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFP 280

Query: 266 SNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTG 325
            +  +E E++++ Y+W++ +++RSQ+EQLL+Q+GKEG F+VR+SS+ G YTVS+F+K+  
Sbjct: 281 ESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVN 340

Query: 326 DPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAP 385
           D +G ++HY V +  +++ YLAE + F +IP+LI+YHQHNSAG+I+RL++PVS +    P
Sbjct: 341 DKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVP 400

Query: 386 STAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEE 445
            +  LG G WE+  +++T LKELG+GQFGVV+ GKW+GQYDVA+KMIKEGSMSEDEF +E
Sbjct: 401 DSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQE 460

Query: 446 AKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDV 505
           A+ MM LSH KLV+ YGVC+K+ PI+I+TEY++NGCLLNYLR      +  QLLEMC DV
Sbjct: 461 AQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDV 520

Query: 506 CEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSP 565
           CE M +LES QF+HRDLAARNCLV+    VKVSDFG++RYVLDD+Y SSVG+KFPV+WS 
Sbjct: 521 CEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSA 580

Query: 566 PEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEK 625
           PEV  Y K+SSKSD+WAFG+LMWE++SLGK PY+ + NS+    ++QG RLYRPHLAS+ 
Sbjct: 581 PEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDT 640

Query: 626 VYTIMYSCWHEKADERPTFKILLSNILDVMDEE 658
           +Y IMYSCWHE  ++RPTF+ LLS+I  + +++
Sbjct: 641 IYQIMYSCWHELPEKRPTFQQLLSSIEPLREKD 673


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  648 bits (1671), Expect = 0.0
 Identities = 327/658 (49%), Positives = 441/658 (67%), Gaps = 50/658 (7%)

Query: 4   VILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITC 63
           ++LE   +K+SQQK++TSP NFK R F+LT   L+Y+E     G++ + KGSI++ +I C
Sbjct: 5   ILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFED--RHGKKRTLKGSIELSRIKC 62

Query: 64  VETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKR 123
           VE V  +                     ISI   + YPFQVV+D   LYVF+P  E R+R
Sbjct: 63  VEIVKSD---------------------ISIPCHYKYPFQVVHDNYLLYVFAPDRESRQR 101

Query: 124 WIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGC-QILENRNGSLKPGSSHR 182
           W+  LK   R N+ LV KYHP FW+DG++ CCSQ  K A GC Q    +N S        
Sbjct: 102 WVLALKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNAS-------- 153

Query: 183 KTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYF 242
             KKPLPPTPE+++             P+   E   V+ALYDY   +  +L LR+ +EY 
Sbjct: 154 --KKPLPPTPEDNR------------RPLWEPEETVVIALYDYQTNDPQELALRRNEEYC 199

Query: 243 ILEESNLPWWRARDKNGQEGYIPSNYVTE-AEDSIEMYEWYSKHMTRSQAEQLLKQEGKE 301
           +L+ S + WWR +D+NG EGY+PS+Y+ E + +++E YEWY+K ++R +AE+LL   GKE
Sbjct: 200 LLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE 259

Query: 302 GGFIVRDSSKAGKYTVSVFAKST-GDPQGVIRHYVVCSTPQS--QYYLAEKHLFSTIPEL 358
           G F+VRDS  AG YTVSVF K+   +    I+HY +  T  +  +YY+AEK++F +IP L
Sbjct: 260 GAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319

Query: 359 INYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKY 418
           INYHQHN  GL++RL+YPV    + AP TAGL YG W IDP +LTF++E+G+GQFG+V  
Sbjct: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHL 379

Query: 419 GKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMA 478
           G W  +  VAIK I+EG+MSE++FIEEA+VMM LSH KLVQLYGVC +Q PI ++ E+M 
Sbjct: 380 GYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFME 439

Query: 479 NGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVS 538
           +GCL +YLR  R  F  + LL MC DVCE M YLE    +HRDLAARNCLV +  V+KVS
Sbjct: 440 HGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVS 499

Query: 539 DFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPY 598
           DFG++R+VLDD+YTSS G+KFPV+W+ PEV  +S++SSKSD+W+FGVLMWE++S GK+PY
Sbjct: 500 DFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPY 559

Query: 599 ERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMD 656
           E  +NSE  E I+ G RLY+P LAS  VY IM  CW E+ ++RP F  LL  + ++ +
Sbjct: 560 ENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAE 617


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  571 bits (1472), Expect = e-163
 Identities = 271/512 (52%), Positives = 362/512 (70%), Gaps = 12/512 (2%)

Query: 154 CCSQTAKNAMGCQILENRNGSLKPGSSHRK-------TKKPLPPTPEEDQILKKPLPPEP 206
           CC    K  M  QI  + +  L    + R+       + K    T       +KPLPP P
Sbjct: 17  CCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLP 76

Query: 207 AAAPVSTSELK-KVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIP 265
              P   +E K +V ALYD++P    +L LR+ +EY ILE+ N  WW+ARD+ G EG IP
Sbjct: 77  ---PSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIP 133

Query: 266 SNYVTEAE-DSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKST 324
           SNYVTE +  ++E+YEWY +++TR+QAE LL+QE KEG FIVRDS   G YT+SVF  + 
Sbjct: 134 SNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGAR 193

Query: 325 GDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNA 384
              +  I+HY +      Q+Y+AE+H F +IPELI YHQHN+AGL++RL+YPV       
Sbjct: 194 RSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCL 253

Query: 385 PSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIE 444
           P+TAG  Y  WEIDP +L F+KE+G+GQFGVV  G+WR    VAIK I EGSMSE++FIE
Sbjct: 254 PATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIE 313

Query: 445 EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD 504
           EAKVMM LSH KLVQLYGVC +++P++I+TE+M NGCLLNYLRE + + + + LL +C+D
Sbjct: 314 EAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQD 373

Query: 505 VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS 564
           +CE MEYLE   ++HRDLAARNCLV+   +VK+SDFG++RYVLDDEY SS G+KFP++WS
Sbjct: 374 ICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWS 433

Query: 565 PPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASE 624
           PPEV +++K+SSKSD+W+FGVLMWE+++ GKMP+E  +N +  E I++G RLYRPHLA  
Sbjct: 434 PPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPM 493

Query: 625 KVYTIMYSCWHEKADERPTFKILLSNILDVMD 656
            +Y +MYSCWHEK + RPTF  LL  + ++ +
Sbjct: 494 SIYEVMYSCWHEKPEGRPTFAELLRAVTEIAE 525


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  340 bits (873), Expect = 2e-93
 Identities = 185/444 (41%), Positives = 268/444 (60%), Gaps = 13/444 (2%)

Query: 205 EPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEES-NLPWWRARDKNGQEGY 263
           E   A  S ++    VALYD++    N L + KG++  +L  + N  W  A+ KNGQ G+
Sbjct: 52  ENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GW 110

Query: 264 IPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAK 322
           +PSNY+T   +S+E + WY   ++R+ AE LL   G  G F+VR+S S  G+ ++S+   
Sbjct: 111 VPSNYITPV-NSLEKHSWYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRY- 167

Query: 323 STGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNK 382
                +G + HY + +    + Y++ +  F+T+ EL+++H   + GLI+ L YP  ++NK
Sbjct: 168 -----EGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNK 222

Query: 383 NAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDE 441
                    Y  WE++  D+T   +LG GQ+G V  G W+     VA+K +KE +M  +E
Sbjct: 223 PTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE 282

Query: 442 FIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLE 500
           F++EA VM  + H  LVQL GVCT++ P +IITE+M  G LL+YLRE  R       LL 
Sbjct: 283 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLY 342

Query: 501 MCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFP 560
           M   +  AMEYLE K F+HRDLAARNCLV +  +VKV+DFGLSR +  D YT+  G+KFP
Sbjct: 343 MATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFP 402

Query: 561 VRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPH 620
           ++W+ PE L Y+KFS KSD+WAFGVL+WEI + G  PY     S+  E + +  R+ RP 
Sbjct: 403 IKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPE 462

Query: 621 LASEKVYTIMYSCWHEKADERPTF 644
              EKVY +M +CW     +RP+F
Sbjct: 463 GCPEKVYELMRACWQWNPSDRPSF 486


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  340 bits (873), Expect = 2e-93
 Identities = 185/444 (41%), Positives = 268/444 (60%), Gaps = 13/444 (2%)

Query: 205 EPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEES-NLPWWRARDKNGQEGY 263
           E   A  S ++    VALYD++    N L + KG++  +L  + N  W  A+ KNGQ G+
Sbjct: 71  ENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GW 129

Query: 264 IPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAK 322
           +PSNY+T   +S+E + WY   ++R+ AE LL   G  G F+VR+S S  G+ ++S+   
Sbjct: 130 VPSNYITPV-NSLEKHSWYHGPVSRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRY- 186

Query: 323 STGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNK 382
                +G + HY + +    + Y++ +  F+T+ EL+++H   + GLI+ L YP  ++NK
Sbjct: 187 -----EGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNK 241

Query: 383 NAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDE 441
                    Y  WE++  D+T   +LG GQ+G V  G W+     VA+K +KE +M  +E
Sbjct: 242 PTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEE 301

Query: 442 FIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLE 500
           F++EA VM  + H  LVQL GVCT++ P +IITE+M  G LL+YLRE  R       LL 
Sbjct: 302 FLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLY 361

Query: 501 MCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFP 560
           M   +  AMEYLE K F+HRDLAARNCLV +  +VKV+DFGLSR +  D YT+  G+KFP
Sbjct: 362 MATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFP 421

Query: 561 VRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPH 620
           ++W+ PE L Y+KFS KSD+WAFGVL+WEI + G  PY     S+  E + +  R+ RP 
Sbjct: 422 IKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPE 481

Query: 621 LASEKVYTIMYSCWHEKADERPTF 644
              EKVY +M +CW     +RP+F
Sbjct: 482 GCPEKVYELMRACWQWNPSDRPSF 505


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  331 bits (848), Expect = 1e-90
 Identities = 182/431 (42%), Positives = 261/431 (60%), Gaps = 17/431 (3%)

Query: 220 VALYDYMPMNANDLQLRKGDEYFILE-ESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEM 278
           VALYD++    N L + KG++  +L    N  W   R KNGQ G++PSNY+T   +S+E 
Sbjct: 98  VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPV-NSLEK 155

Query: 279 YEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVC 337
           + WY   ++RS AE LL      G F+VR+S S  G+ ++S+        +G + HY + 
Sbjct: 156 HSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISLRY------EGRVYHYRIN 208

Query: 338 STPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG--YGSW 395
           +T   + Y+  +  FST+ EL+++H   + GL++ L YP  + NK  P+  G+   +  W
Sbjct: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 266

Query: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
           E++  D+T   +LG GQ+G V  G W+     VA+K +KE +M  +EF++EA VM  + H
Sbjct: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326

Query: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLE 513
             LVQL GVCT + P +I+TEYM  G LL+YLRE  R       LL M   +  AMEYLE
Sbjct: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386

Query: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573
            K F+HRDLAARNCLV +  VVKV+DFGLSR +  D YT+  G+KFP++W+ PE L Y+ 
Sbjct: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446

Query: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633
           FS KSD+WAFGVL+WEI + G  PY     S+  + + +G R+ +P     KVY +M +C
Sbjct: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506

Query: 634 WHEKADERPTF 644
           W     +RP+F
Sbjct: 507 WKWSPADRPSF 517


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  331 bits (848), Expect = 1e-90
 Identities = 182/431 (42%), Positives = 261/431 (60%), Gaps = 17/431 (3%)

Query: 220 VALYDYMPMNANDLQLRKGDEYFILE-ESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEM 278
           VALYD++    N L + KG++  +L    N  W   R KNGQ G++PSNY+T   +S+E 
Sbjct: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPV-NSLEK 170

Query: 279 YEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVC 337
           + WY   ++RS AE LL      G F+VR+S S  G+ ++S+        +G + HY + 
Sbjct: 171 HSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISLRY------EGRVYHYRIN 223

Query: 338 STPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG--YGSW 395
           +T   + Y+  +  FST+ EL+++H   + GL++ L YP  + NK  P+  G+   +  W
Sbjct: 224 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 281

Query: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
           E++  D+T   +LG GQ+G V  G W+     VA+K +KE +M  +EF++EA VM  + H
Sbjct: 282 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341

Query: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLE 513
             LVQL GVCT + P +I+TEYM  G LL+YLRE  R       LL M   +  AMEYLE
Sbjct: 342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 401

Query: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573
            K F+HRDLAARNCLV +  VVKV+DFGLSR +  D YT+  G+KFP++W+ PE L Y+ 
Sbjct: 402 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 461

Query: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633
           FS KSD+WAFGVL+WEI + G  PY     S+  + + +G R+ +P     KVY +M +C
Sbjct: 462 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 521

Query: 634 WHEKADERPTF 644
           W     +RP+F
Sbjct: 522 WKWSPADRPSF 532


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  331 bits (848), Expect = 1e-90
 Identities = 182/431 (42%), Positives = 261/431 (60%), Gaps = 17/431 (3%)

Query: 220 VALYDYMPMNANDLQLRKGDEYFILE-ESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEM 278
           VALYD++    N L + KG++  +L    N  W   R KNGQ G++PSNY+T   +S+E 
Sbjct: 92  VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPV-NSLEK 149

Query: 279 YEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVC 337
           + WY   ++RS AE LL      G F+VR+S S  G+ ++S+        +G + HY + 
Sbjct: 150 HSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISLRY------EGRVYHYRIN 202

Query: 338 STPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG--YGSW 395
           +T   + Y+  +  FST+ EL+++H   + GL++ L YP  + NK  P+  G+   +  W
Sbjct: 203 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 260

Query: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
           E++  D+T   +LG GQ+G V  G W+     VA+K +KE +M  +EF++EA VM  + H
Sbjct: 261 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 320

Query: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLE 513
             LVQL GVCT + P +I+TEYM  G LL+YLRE  R       LL M   +  AMEYLE
Sbjct: 321 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 380

Query: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573
            K F+HRDLAARNCLV +  VVKV+DFGLSR +  D YT+  G+KFP++W+ PE L Y+ 
Sbjct: 381 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 440

Query: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633
           FS KSD+WAFGVL+WEI + G  PY     S+  + + +G R+ +P     KVY +M +C
Sbjct: 441 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 500

Query: 634 WHEKADERPTF 644
           W     +RP+F
Sbjct: 501 WKWSPADRPSF 511


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  331 bits (848), Expect = 1e-90
 Identities = 182/431 (42%), Positives = 261/431 (60%), Gaps = 17/431 (3%)

Query: 220 VALYDYMPMNANDLQLRKGDEYFILE-ESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEM 278
           VALYD++    N L + KG++  +L    N  W   R KNGQ G++PSNY+T   +S+E 
Sbjct: 98  VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPV-NSLEK 155

Query: 279 YEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVC 337
           + WY   ++RS AE LL      G F+VR+S S  G+ ++S+        +G + HY + 
Sbjct: 156 HSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISLRY------EGRVYHYRIN 208

Query: 338 STPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG--YGSW 395
           +T   + Y+  +  FST+ EL+++H   + GL++ L YP  + NK  P+  G+   +  W
Sbjct: 209 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 266

Query: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
           E++  D+T   +LG GQ+G V  G W+     VA+K +KE +M  +EF++EA VM  + H
Sbjct: 267 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 326

Query: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLE 513
             LVQL GVCT + P +I+TEYM  G LL+YLRE  R       LL M   +  AMEYLE
Sbjct: 327 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 386

Query: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573
            K F+HRDLAARNCLV +  VVKV+DFGLSR +  D YT+  G+KFP++W+ PE L Y+ 
Sbjct: 387 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 446

Query: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633
           FS KSD+WAFGVL+WEI + G  PY     S+  + + +G R+ +P     KVY +M +C
Sbjct: 447 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 506

Query: 634 WHEKADERPTF 644
           W     +RP+F
Sbjct: 507 WKWSPADRPSF 517


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  331 bits (848), Expect = 1e-90
 Identities = 182/431 (42%), Positives = 261/431 (60%), Gaps = 17/431 (3%)

Query: 220 VALYDYMPMNANDLQLRKGDEYFILE-ESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEM 278
           VALYD++    N L + KG++  +L    N  W   R KNGQ G++PSNY+T   +S+E 
Sbjct: 77  VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQ-GWVPSNYITPV-NSLEK 134

Query: 279 YEWYSKHMTRSQAEQLLKQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGDPQGVIRHYVVC 337
           + WY   ++RS AE LL      G F+VR+S S  G+ ++S+        +G + HY + 
Sbjct: 135 HSWYHGPVSRSAAEYLLSSL-INGSFLVRESESSPGQLSISLRY------EGRVYHYRIN 187

Query: 338 STPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLG--YGSW 395
           +T   + Y+  +  FST+ EL+++H   + GL++ L YP  + NK  P+  G+   +  W
Sbjct: 188 TTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTVYGVSPIHDKW 245

Query: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRG-QYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
           E++  D+T   +LG GQ+G V  G W+     VA+K +KE +M  +EF++EA VM  + H
Sbjct: 246 EMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 305

Query: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAMEYLE 513
             LVQL GVCT + P +I+TEYM  G LL+YLRE  R       LL M   +  AMEYLE
Sbjct: 306 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLE 365

Query: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573
            K F+HRDLAARNCLV +  VVKV+DFGLSR +  D YT+  G+KFP++W+ PE L Y+ 
Sbjct: 366 KKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNT 425

Query: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633
           FS KSD+WAFGVL+WEI + G  PY     S+  + + +G R+ +P     KVY +M +C
Sbjct: 426 FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRAC 485

Query: 634 WHEKADERPTF 644
           W     +RP+F
Sbjct: 486 WKWSPADRPSF 496


>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  329 bits (843), Expect = 6e-90
 Identities = 176/455 (38%), Positives = 277/455 (60%), Gaps = 16/455 (3%)

Query: 205 EPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGY 263
           E +  P S  +   V+AL+ Y P +  DL   KG++  ILE+S   WW+A+    GQEG+
Sbjct: 52  EGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEGF 110

Query: 264 IPSNYVTEAEDSIEMYEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDS-SKAGKYTVSV-- 319
           IP N+V +A +S+E   W+ K+++R  AE QLL      G F++R+S S AG +++SV  
Sbjct: 111 IPFNFVAKA-NSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRD 169

Query: 320 FAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQ 379
           F ++ G+   V++HY + +     +Y++ +  F  + EL+ ++ + S GL +RL  P   
Sbjct: 170 FDQNQGE---VVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQT 226

Query: 380 QNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSE 439
           Q    P         WE+  + L  ++ LG GQFG V  G + G   VA+K +K+GSMS 
Sbjct: 227 QKPQKPWWED----EWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSP 282

Query: 440 DEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRH-RFQTQQL 498
           D F+ EA +M  L H++LV+LY V T Q PI+IITEYM NG L+++L+     +    +L
Sbjct: 283 DAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLTINKL 341

Query: 499 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSK 558
           L+M   + E M ++E + ++HRDL A N LV+D    K++DFGL+R + D+EYT+  G+K
Sbjct: 342 LDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAK 401

Query: 559 FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR 618
           FP++W+ PE + Y  F+ KSD+W+FG+L+ EI + G++PY   TN E  +++ +G R+ R
Sbjct: 402 FPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVR 461

Query: 619 PHLASEKVYTIMYSCWHEKADERPTFKILLSNILD 653
           P    E++Y +M  CW E+ ++RPTF  L S + D
Sbjct: 462 PDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLED 496


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  329 bits (843), Expect = 6e-90
 Identities = 176/455 (38%), Positives = 277/455 (60%), Gaps = 16/455 (3%)

Query: 205 EPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGY 263
           E +  P S  +   V+AL+ Y P +  DL   KG++  ILE+S   WW+A+    GQEG+
Sbjct: 52  EGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEGF 110

Query: 264 IPSNYVTEAEDSIEMYEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDS-SKAGKYTVSV-- 319
           IP N+V +A +S+E   W+ K+++R  AE QLL      G F++R+S S AG +++SV  
Sbjct: 111 IPFNFVAKA-NSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRD 169

Query: 320 FAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQ 379
           F ++ G+   V++HY + +     +Y++ +  F  + EL+ ++ + S GL +RL  P   
Sbjct: 170 FDQNQGE---VVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQT 226

Query: 380 QNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSE 439
           Q    P         WE+  + L  ++ LG GQFG V  G + G   VA+K +K+GSMS 
Sbjct: 227 QKPQKPWWED----EWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSP 282

Query: 440 DEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRH-RFQTQQL 498
           D F+ EA +M  L H++LV+LY V T Q PI+IITEYM NG L+++L+     +    +L
Sbjct: 283 DAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLTINKL 341

Query: 499 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSK 558
           L+M   + E M ++E + ++HRDL A N LV+D    K++DFGL+R + D+EYT+  G+K
Sbjct: 342 LDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAK 401

Query: 559 FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR 618
           FP++W+ PE + Y  F+ KSD+W+FG+L+ EI + G++PY   TN E  +++ +G R+ R
Sbjct: 402 FPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVR 461

Query: 619 PHLASEKVYTIMYSCWHEKADERPTFKILLSNILD 653
           P    E++Y +M  CW E+ ++RPTF  L S + D
Sbjct: 462 PDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLED 496


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  324 bits (831), Expect = 1e-88
 Identities = 185/473 (39%), Positives = 274/473 (57%), Gaps = 26/473 (5%)

Query: 204 PEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRAR------DK 257
           P    +P S       VAL+DY    A DL  R GD+  +L+  +  WW AR      D 
Sbjct: 32  PGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDG 91

Query: 258 NGQE--GYIPSNYVTEAEDSIEMYEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDS-SKAG 313
           + Q+  GYIPSNYV E + S++   W+   + RS AE QLL  E K G F++R+S S+ G
Sbjct: 92  SSQQLQGYIPSNYVAE-DRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKG 150

Query: 314 KYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRL 373
           ++++SV   +      V++HY +    +  ++L  + +FST+ E ++++   S GL  +L
Sbjct: 151 EFSLSVLDGA------VVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKL 204

Query: 374 KYPVSQQNKNAPSTAGLGYGS---WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIK 430
             P  +    AP    L Y +   WEID   +  LK LG+GQFG V  G W     VA+K
Sbjct: 205 GKPCLKIQVPAPFD--LSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVK 262

Query: 431 MIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR-EM 489
            +K GSM  ++F+ EA++M NL H KL+QLY VCT + PI+IITE M +G L  YL+ + 
Sbjct: 263 TLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDT 322

Query: 490 RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR-YVLD 548
             +    Q ++M   V   M YLES+ ++HRDLAARN LV +  + KV+DFGL+R + +D
Sbjct: 323 GSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVD 382

Query: 549 DE--YTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSET 606
           +E  Y S    K PV+W+ PE +  +KFS KSD+W+FG+L++EI + GKMPY   T ++ 
Sbjct: 383 NEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQV 442

Query: 607 AEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES 659
            + +AQ  RL +P    ++ Y IM  CW+ +  ERPTF+ L   + D  + +S
Sbjct: 443 IQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDS 495


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score =  323 bits (827), Expect = 4e-88
 Identities = 175/441 (39%), Positives = 265/441 (60%), Gaps = 17/441 (3%)

Query: 219 VVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIE 277
           VVALYDY  ++  DL  +KGD+  +LEES   WW+AR     +EGYIPSNYV    DS+E
Sbjct: 83  VVALYDYEAIHHEDLSFQKGDQMVVLEESG-EWWKARSLATRKEGYIPSNYVARV-DSLE 140

Query: 278 MYEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSV--FAKSTGDPQGVIRH 333
             EW+ K ++R  AE QLL      G F++RDS    G Y++SV  +    GD    ++H
Sbjct: 141 TEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGD---TVKH 197

Query: 334 YVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYG 393
           Y + +     +Y++ +  FST+ EL+++++  + GL  +L  P        P        
Sbjct: 198 YKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKD---- 253

Query: 394 SWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS 453
           +WEI  + L   K+LG GQFG V    +     VA+K +K GSMS + F+ EA VM  L 
Sbjct: 254 AWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQ 313

Query: 454 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQT-QQLLEMCKDVCEAMEYL 512
           H+KLV+L+ V TK+ PI+IITE+MA G LL++L+      Q   +L++    + E M ++
Sbjct: 314 HDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFI 372

Query: 513 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYS 572
           E + ++HRDL A N LV+   V K++DFGL+R + D+EYT+  G+KFP++W+ PE + + 
Sbjct: 373 EQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG 432

Query: 573 KFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYS 632
            F+ KSD+W+FG+L+ EI + G++PY   +N E    + +G R+ RP    E++Y IM  
Sbjct: 433 SFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMR 492

Query: 633 CWHEKADERPTFKILLSNILD 653
           CW  + +ERPTF+ + S +LD
Sbjct: 493 CWKNRPEERPTFEYIQS-VLD 512


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  322 bits (824), Expect = 9e-88
 Identities = 175/441 (39%), Positives = 269/441 (60%), Gaps = 16/441 (3%)

Query: 219 VVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDK-NGQEGYIPSNYVTEAEDSIE 277
           VVALY Y  ++ +DL  +KG++  +LEE    WW+A+     +EG+IPSNYV +  +++E
Sbjct: 47  VVALYPYDGIHPDDLSFKKGEKMKVLEEHG-EWWKAKSLLTKKEGFIPSNYVAKL-NTLE 104

Query: 278 MYEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSV--FAKSTGDPQGVIRH 333
             EW+ K +TR  AE QLL      G F++R+S    G +++SV  F    GD   VI+H
Sbjct: 105 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGD---VIKH 161

Query: 334 YVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYG 393
           Y + S     YY++ +  F  I ++I ++Q  + GL  RL+          P        
Sbjct: 162 YKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKD---- 217

Query: 394 SWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS 453
           +WEI  + +  +K LG GQFG V  G +     VA+K +K G+MS   F+EEA +M  L 
Sbjct: 218 AWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQ 277

Query: 454 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYL 512
           H+KLV+LY V T++ PI+IITEYMA G LL++L+ +   +    +L++    + E M Y+
Sbjct: 278 HDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYI 337

Query: 513 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYS 572
           E K ++HRDL A N LV++  + K++DFGL+R + D+EYT+  G+KFP++W+ PE + + 
Sbjct: 338 ERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG 397

Query: 573 KFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYS 632
            F+ KSD+W+FG+L++EI + GK+PY   TN++    ++QG R+ R     +++Y IM  
Sbjct: 398 CFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKM 457

Query: 633 CWHEKADERPTFKILLSNILD 653
           CW EKA+ERPTF  L S +LD
Sbjct: 458 CWKEKAEERPTFDYLQS-VLD 477


>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score =  322 bits (824), Expect = 9e-88
 Identities = 175/441 (39%), Positives = 269/441 (60%), Gaps = 16/441 (3%)

Query: 219 VVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDK-NGQEGYIPSNYVTEAEDSIE 277
           VVALY Y  ++ +DL  +KG++  +LEE    WW+A+     +EG+IPSNYV +  +++E
Sbjct: 68  VVALYPYDGIHPDDLSFKKGEKMKVLEEHG-EWWKAKSLLTKKEGFIPSNYVAKL-NTLE 125

Query: 278 MYEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSV--FAKSTGDPQGVIRH 333
             EW+ K +TR  AE QLL      G F++R+S    G +++SV  F    GD   VI+H
Sbjct: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGD---VIKH 182

Query: 334 YVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYG 393
           Y + S     YY++ +  F  I ++I ++Q  + GL  RL+          P        
Sbjct: 183 YKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKD---- 238

Query: 394 SWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS 453
           +WEI  + +  +K LG GQFG V  G +     VA+K +K G+MS   F+EEA +M  L 
Sbjct: 239 AWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQ 298

Query: 454 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYL 512
           H+KLV+LY V T++ PI+IITEYMA G LL++L+ +   +    +L++    + E M Y+
Sbjct: 299 HDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYI 358

Query: 513 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYS 572
           E K ++HRDL A N LV++  + K++DFGL+R + D+EYT+  G+KFP++W+ PE + + 
Sbjct: 359 ERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG 418

Query: 573 KFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYS 632
            F+ KSD+W+FG+L++EI + GK+PY   TN++    ++QG R+ R     +++Y IM  
Sbjct: 419 CFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKM 478

Query: 633 CWHEKADERPTFKILLSNILD 653
           CW EKA+ERPTF  L S +LD
Sbjct: 479 CWKEKAEERPTFDYLQS-VLD 498


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  321 bits (822), Expect = 2e-87
 Identities = 172/442 (38%), Positives = 258/442 (58%), Gaps = 15/442 (3%)

Query: 220 VALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEM 278
           VALYDY     +DL   KG+++ IL  S   WW AR    G+ GYIPSNYV    DSI+ 
Sbjct: 88  VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV-DSIQA 146

Query: 279 YEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSVFAKSTGDPQGV-IRHYV 335
            EWY   + R  AE QLL      G F++R+S    G Y++S+  +   D +G  ++HY 
Sbjct: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSI--RDWDDMKGDHVKHYK 204

Query: 336 VCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGS- 394
           +       YY+  +  F T+ +L+ ++   +AGL  RL  P    +K  P    L   + 
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPC---HKGMPRLTDLSVKTK 261

Query: 395 --WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 452
             WEI  + L  +K LG GQFG V  G W G   VAIK +K G+MS + F+EEA++M  L
Sbjct: 262 DVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKL 321

Query: 453 SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEY 511
            H+KLVQLY V +++ PI+I+TEYM  G LL++L++   R  +   L++M   V   M Y
Sbjct: 322 KHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAY 380

Query: 512 LESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMY 571
           +E   ++HRDL + N LV +  + K++DFGL+R + D+EYT+  G+KFP++W+ PE  +Y
Sbjct: 381 IERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 440

Query: 572 SKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMY 631
            +F+ KSD+W+FG+L+ E+ + G++PY    N E  E + +G R+  P      ++ +M 
Sbjct: 441 GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMI 500

Query: 632 SCWHEKADERPTFKILLSNILD 653
            CW +  +ERPTF+ L S + D
Sbjct: 501 HCWKKDPEERPTFEYLQSFLED 522


>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score =  319 bits (818), Expect = 4e-87
 Identities = 178/479 (37%), Positives = 276/479 (57%), Gaps = 19/479 (3%)

Query: 179 SSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKG 238
           S+  K   PLPP    + +   P PP+         +   VVALYDY  MN  DLQ+ KG
Sbjct: 29  SAQDKDAPPLPPLVVFNHLT--PPPPDEHL----DEDKHFVVALYDYTAMNDRDLQMLKG 82

Query: 239 DEYFILEESNLPWWRARDK-NGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAE-QLLK 296
           ++  +L+ +   WW AR    G+EGY+PSN+V   E S+EM  W+ +   R +AE QLL 
Sbjct: 83  EKLQVLKGTG-DWWLARSLVTGREGYVPSNFVARVE-SLEMERWFFRSQGRKEAERQLLA 140

Query: 297 QEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIP 356
              K G F++R+S +  K   S+  K       +I+HY +    +  YY++ +  F ++ 
Sbjct: 141 PINKAGSFLIRES-ETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQ 199

Query: 357 ELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVV 416
            L+ ++     GL  RL  P  +     P         WEI  + L  +++LG+GQFG V
Sbjct: 200 ALVQHYSKKGDGLCQRLTLPCVRPAPQNP----WAQDEWEIPRQSLRLVRKLGSGQFGEV 255

Query: 417 KYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEY 476
             G ++    VAIK +KEG+MS + F+ EA VM  L HE+LV+LY V TK+ PI+I+TEY
Sbjct: 256 WMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PIYIVTEY 314

Query: 477 MANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVV 535
           MA GCLL++L+ +   R    +L++M   + E M Y+E    +HRDL A N LV++    
Sbjct: 315 MARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCC 374

Query: 536 KVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGK 595
           K++DFGL+R ++D EYT+  G+KFP++W+ PE + +  F+ K+D+W+FGVL+ E+ + G+
Sbjct: 375 KIADFGLAR-IIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGR 433

Query: 596 MPYERFTNSETAEHIAQGLRLYRPHLASEKVYT-IMYSCWHEKADERPTFKILLSNILD 653
           +PY   +N E   ++ +G R+ RP     ++Y  ++  CW  + +ERPTF+ L S + D
Sbjct: 434 VPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLED 492


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  318 bits (816), Expect = 8e-87
 Identities = 184/496 (37%), Positives = 279/496 (56%), Gaps = 32/496 (6%)

Query: 176 KPGSS--HRKTKKPLPPTPEEDQI---------LKKPLPPEPAAAPVSTSELKKVVALYD 224
           KP S+  HR       P   E ++         +  P    P A  V+T      VALYD
Sbjct: 40  KPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTT-----FVALYD 94

Query: 225 YMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEMYEWYS 283
           Y      DL  +KG+   I+  +   WW A     GQ GYIPSNYV  + DSI+  EWY 
Sbjct: 95  YESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS-DSIQAEEWYF 153

Query: 284 KHMTRSQAEQLL-KQEGKEGGFIVRDSSKA-GKYTVSVFAKSTGDPQGV-IRHYVVCSTP 340
             +TR ++E+LL   E   G F+VR+S    G Y +SV      + +G+ ++HY +    
Sbjct: 154 GKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV--SDFDNAKGLNVKHYKIRKLD 211

Query: 341 QSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKY--PVSQQNKNAPSTAGLGYGSWEID 398
              +Y+  +  F+++ +L+ Y+  ++ GL  RL    P S+     P T GL   +WEI 
Sbjct: 212 SGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSK-----PQTQGLAKDAWEIP 266

Query: 399 PKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLV 458
            + L    +LG G FG V  G W G   VAIK +K G+MS + F++EA+VM  L HEKLV
Sbjct: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326

Query: 459 QLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYLESKQF 517
           QLY V +++ PI+I+TEYM+ G LL++L+ E     +  QL++M   +   M Y+E   +
Sbjct: 327 QLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385

Query: 518 LHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSK 577
           +HRDL A N LV +  V KV+DFGL+R + D+EYT+  G+KFP++W+ PE  +Y +F+ K
Sbjct: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445

Query: 578 SDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEK 637
           SD+W+FG+L+ E+ + G++PY    N E  + + +G R+  P    E ++ +M  CW ++
Sbjct: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505

Query: 638 ADERPTFKILLSNILD 653
            +ERPTF+ L + + D
Sbjct: 506 PEERPTFEYLQAFLED 521


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  318 bits (816), Expect = 8e-87
 Identities = 184/496 (37%), Positives = 279/496 (56%), Gaps = 32/496 (6%)

Query: 176 KPGSS--HRKTKKPLPPTPEEDQI---------LKKPLPPEPAAAPVSTSELKKVVALYD 224
           KP S+  HR       P   E ++         +  P    P A  V+T      VALYD
Sbjct: 40  KPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTT-----FVALYD 94

Query: 225 YMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEMYEWYS 283
           Y      DL  +KG+   I+  +   WW A     GQ GYIPSNYV  + DSI+  EWY 
Sbjct: 95  YESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS-DSIQAEEWYF 153

Query: 284 KHMTRSQAEQLL-KQEGKEGGFIVRDSSKA-GKYTVSVFAKSTGDPQGV-IRHYVVCSTP 340
             +TR ++E+LL   E   G F+VR+S    G Y +SV      + +G+ ++HY +    
Sbjct: 154 GKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV--SDFDNAKGLNVKHYKIRKLD 211

Query: 341 QSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKY--PVSQQNKNAPSTAGLGYGSWEID 398
              +Y+  +  F+++ +L+ Y+  ++ GL  RL    P S+     P T GL   +WEI 
Sbjct: 212 SGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSK-----PQTQGLAKDAWEIP 266

Query: 399 PKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLV 458
            + L    +LG G FG V  G W G   VAIK +K G+MS + F++EA+VM  L HEKLV
Sbjct: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326

Query: 459 QLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYLESKQF 517
           QLY V +++ PI+I+TEYM+ G LL++L+ E     +  QL++M   +   M Y+E   +
Sbjct: 327 QLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385

Query: 518 LHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSK 577
           +HRDL A N LV +  V KV+DFGL+R + D+EYT+  G+KFP++W+ PE  +Y +F+ K
Sbjct: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445

Query: 578 SDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEK 637
           SD+W+FG+L+ E+ + G++PY    N E  + + +G R+  P    E ++ +M  CW ++
Sbjct: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505

Query: 638 ADERPTFKILLSNILD 653
            +ERPTF+ L + + D
Sbjct: 506 PEERPTFEYLQAFLED 521


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  318 bits (814), Expect = 1e-86
 Identities = 171/455 (37%), Positives = 265/455 (58%), Gaps = 15/455 (3%)

Query: 206 PAAAPVS-TSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGY 263
           P++ P   T  +   VALYDY      DL  +KG+ + I+  +   WW AR    G+ GY
Sbjct: 82  PSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGY 141

Query: 264 IPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGG-FIVRDSSKA-GKYTVSV-- 319
           IPSNYV  A DSI+  EWY   M R  AE+LL   G + G F+VR+S    G Y++S+  
Sbjct: 142 IPSNYVAPA-DSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRD 200

Query: 320 FAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQ 379
           + +  GD    ++HY +       YY+  +  F T+ +L+ ++  ++ GL  +L      
Sbjct: 201 WDEIRGDN---VKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPT 257

Query: 380 QNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSE 439
                P T GL   +WEI  + L    +LG G FG V  G W G   VAIK +K G+M  
Sbjct: 258 VK---PQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMP 314

Query: 440 DEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRF-QTQQL 498
           + F++EA++M  L H+KLV LY V +++ PI+I+TE+M+ G LL++L+E   ++ +  QL
Sbjct: 315 EAFLQEAQIMKKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLKEGDGKYLKLPQL 373

Query: 499 LEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSK 558
           ++M   + + M Y+E   ++HRDL A N LV +  V K++DFGL+R + D+EYT+  G+K
Sbjct: 374 VDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAK 433

Query: 559 FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYR 618
           FP++W+ PE  +Y +F+ KSD+W+FG+L  E+ + G++PY    N E  E + +G R+  
Sbjct: 434 FPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPC 493

Query: 619 PHLASEKVYTIMYSCWHEKADERPTFKILLSNILD 653
           P    E ++ +M  CW +  DERPTF+ + S + D
Sbjct: 494 PQGCPESLHELMNLCWKKDPDERPTFEYIQSFLED 528


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  315 bits (807), Expect = 8e-86
 Identities = 168/439 (38%), Positives = 255/439 (58%), Gaps = 12/439 (2%)

Query: 220 VALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEM 278
           VALYDY     +DL   KG+++ IL  S   WW AR    G+ GYIPSNYV    DSI+ 
Sbjct: 88  VALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPV-DSIQA 146

Query: 279 YEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSVFAKSTGDPQGV-IRHYV 335
            EWY   + R  AE QLL      G F++R+S    G Y++S+  +   D +G  ++HY 
Sbjct: 147 EEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSI--RDWDDMKGDHVKHYK 204

Query: 336 VCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSW 395
           +       YY+  +  F T+ +L+ ++   + GL   L    S      P T+GL   +W
Sbjct: 205 IRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCT---PQTSGLAKDAW 261

Query: 396 EIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE 455
           E+  + L   K+LG G F  V  G W G   VAIK +K G+MS + F+EEA++M  L H+
Sbjct: 262 EVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHD 321

Query: 456 KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEYLES 514
           KLVQLY V +++ PI+I+TEYM  G LL++L++   R  +   L++M   V   M Y+E 
Sbjct: 322 KLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER 380

Query: 515 KQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKF 574
             ++HRDL + N LV +  + K++DFGL+R + D+EYT+  G+KFP++W+ PE  +Y +F
Sbjct: 381 MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 440

Query: 575 SSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCW 634
           + KSD+W+FG+L+ E+ + G++PY    N E  E + +G R+  P      ++ +M  CW
Sbjct: 441 TIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCW 500

Query: 635 HEKADERPTFKILLSNILD 653
            +  +ERPTF+ L S + D
Sbjct: 501 KKDPEERPTFEYLQSFLED 519


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  310 bits (793), Expect = 4e-84
 Identities = 167/440 (37%), Positives = 254/440 (57%), Gaps = 14/440 (3%)

Query: 220 VALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEM 278
           +ALYDY     +DL   KG+++ IL  +   WW AR   +G+ G IPSNYV    DSI+ 
Sbjct: 83  IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV-DSIQA 141

Query: 279 YEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSV--FAKSTGDPQGVIRHY 334
            EWY   + R  AE QLL     +G F++R+S    G Y++S+  + ++ GD    ++HY
Sbjct: 142 EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH---VKHY 198

Query: 335 VVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGS 394
            +       YY+  +  F+++ EL+ ++   + GL + L  P +      P T GL   +
Sbjct: 199 KIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLGLAKDA 255

Query: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
           WEI    +T  + LGTG FG V  G W G   VA+K +K G+MS   F+EEA+VM  L H
Sbjct: 256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRH 315

Query: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEYLE 513
           +KLVQLY V +++ PI+I+TE+M +G LL++L+    +  +  QL++M   V E M Y+E
Sbjct: 316 DKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYME 374

Query: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573
              ++HRDL A N LV ++   K++DFGL+R + DDEY    GSKFP++W+ PE  ++ +
Sbjct: 375 RMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGR 434

Query: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633
           F+ KSD+W+FG+L+ E+ + G++PY      E  E + QG  +  P      +Y  M   
Sbjct: 435 FTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQT 494

Query: 634 WHEKADERPTFKILLSNILD 653
           W    +ERPTF+ L S + D
Sbjct: 495 WRLDPEERPTFEYLQSFLED 514


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  310 bits (793), Expect = 4e-84
 Identities = 167/440 (37%), Positives = 254/440 (57%), Gaps = 14/440 (3%)

Query: 220 VALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEM 278
           +ALYDY     +DL   KG+++ IL  +   WW AR   +G+ G IPSNYV    DSI+ 
Sbjct: 83  IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV-DSIQA 141

Query: 279 YEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSV--FAKSTGDPQGVIRHY 334
            EWY   + R  AE QLL     +G F++R+S    G Y++S+  + ++ GD    ++HY
Sbjct: 142 EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH---VKHY 198

Query: 335 VVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGS 394
            +       YY+  +  F+++ EL+ ++   + GL + L  P +      P T GL   +
Sbjct: 199 KIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLGLAKDA 255

Query: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
           WEI    +T  + LGTG FG V  G W G   VA+K +K G+MS   F+EEA+VM  L H
Sbjct: 256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRH 315

Query: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEYLE 513
           +KLVQLY V +++ PI+I+TE+M +G LL++L+    +  +  QL++M   V E M Y+E
Sbjct: 316 DKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYME 374

Query: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573
              ++HRDL A N LV ++   K++DFGL+R + DDEY    GSKFP++W+ PE  ++ +
Sbjct: 375 RMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGR 434

Query: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633
           F+ KSD+W+FG+L+ E+ + G++PY      E  E + QG  +  P      +Y  M   
Sbjct: 435 FTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQT 494

Query: 634 WHEKADERPTFKILLSNILD 653
           W    +ERPTF+ L S + D
Sbjct: 495 WRLDPEERPTFEYLQSFLED 514


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  310 bits (793), Expect = 4e-84
 Identities = 167/440 (37%), Positives = 254/440 (57%), Gaps = 14/440 (3%)

Query: 220 VALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARD-KNGQEGYIPSNYVTEAEDSIEM 278
           +ALYDY     +DL   KG+++ IL  +   WW AR   +G+ G IPSNYV    DSI+ 
Sbjct: 83  IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPV-DSIQA 141

Query: 279 YEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSV--FAKSTGDPQGVIRHY 334
            EWY   + R  AE QLL     +G F++R+S    G Y++S+  + ++ GD    ++HY
Sbjct: 142 EEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH---VKHY 198

Query: 335 VVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGS 394
            +       YY+  +  F+++ EL+ ++   + GL + L  P +      P T GL   +
Sbjct: 199 KIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMK---PQTLGLAKDA 255

Query: 395 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSH 454
           WEI    +T  + LGTG FG V  G W G   VA+K +K G+MS   F+EEA+VM  L H
Sbjct: 256 WEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRH 315

Query: 455 EKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEYLE 513
           +KLVQLY V +++ PI+I+TE+M +G LL++L+    +  +  QL++M   V E M Y+E
Sbjct: 316 DKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYME 374

Query: 514 SKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSK 573
              ++HRDL A N LV ++   K++DFGL+R + DDEY    GSKFP++W+ PE  ++ +
Sbjct: 375 RMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGR 434

Query: 574 FSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSC 633
           F+ KSD+W+FG+L+ E+ + G++PY      E  E + QG  +  P      +Y  M   
Sbjct: 435 FTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQT 494

Query: 634 WHEKADERPTFKILLSNILD 653
           W    +ERPTF+ L S + D
Sbjct: 495 WRLDPEERPTFEYLQSFLED 514


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  271 bits (692), Expect = 2e-72
 Identities = 166/448 (37%), Positives = 248/448 (55%), Gaps = 24/448 (5%)

Query: 220 VALYDYMPMNANDLQLRKGDEYFILEESNLP-WWRARDKNGQEGYIPSNYVTEAED---- 274
           +A Y++      DL   KGD   I+  +  P W++A++K G+EG IP+NYV + E     
Sbjct: 15  IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74

Query: 275 -SIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSK-AGKYTVSVFAKSTGDPQGVIR 332
             + +  W+   +TR QAE+LL    + G F+VR+S+   G YT+ V         G + 
Sbjct: 75  TKLSLMPWFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSC------DGKVE 127

Query: 333 HYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGY 392
           HY +     S+  + E+  F  + +L+ ++  ++ GL +RL  P   +   A        
Sbjct: 128 HYRIMYHA-SKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRS 186

Query: 393 GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 452
           G W ++ K+L  L+ +G G+FG V  G +RG   VA+K IK  + ++  F+ EA VM  L
Sbjct: 187 G-WALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMTQL 243

Query: 453 SHEKLVQLYGVCTKQRP-IFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAME 510
            H  LVQL GV  +++  ++I+TEYMA G L++YLR   R       LL+   DVCEAME
Sbjct: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303

Query: 511 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM 570
           YLE   F+HRDLAARN LV++  V KVSDFGL++     + T     K PV+W+ PE L 
Sbjct: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALR 359

Query: 571 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIM 630
             KFS+KSD+W+FG+L+WEIYS G++PY R    +    + +G ++  P      VY +M
Sbjct: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419

Query: 631 YSCWHEKADERPTFKILLSNILDVMDEE 658
            +CWH  A  RP+F  L   +  +   E
Sbjct: 420 KNCWHLDAAMRPSFLQLREQLEHIKTHE 447


>gi|4758078 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  271 bits (692), Expect = 2e-72
 Identities = 166/448 (37%), Positives = 248/448 (55%), Gaps = 24/448 (5%)

Query: 220 VALYDYMPMNANDLQLRKGDEYFILEESNLP-WWRARDKNGQEGYIPSNYVTEAED---- 274
           +A Y++      DL   KGD   I+  +  P W++A++K G+EG IP+NYV + E     
Sbjct: 15  IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74

Query: 275 -SIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSK-AGKYTVSVFAKSTGDPQGVIR 332
             + +  W+   +TR QAE+LL    + G F+VR+S+   G YT+ V         G + 
Sbjct: 75  TKLSLMPWFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSC------DGKVE 127

Query: 333 HYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGY 392
           HY +     S+  + E+  F  + +L+ ++  ++ GL +RL  P   +   A        
Sbjct: 128 HYRIMYHA-SKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRS 186

Query: 393 GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 452
           G W ++ K+L  L+ +G G+FG V  G +RG   VA+K IK  + ++  F+ EA VM  L
Sbjct: 187 G-WALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMTQL 243

Query: 453 SHEKLVQLYGVCTKQRP-IFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAME 510
            H  LVQL GV  +++  ++I+TEYMA G L++YLR   R       LL+   DVCEAME
Sbjct: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303

Query: 511 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM 570
           YLE   F+HRDLAARN LV++  V KVSDFGL++     + T     K PV+W+ PE L 
Sbjct: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALR 359

Query: 571 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIM 630
             KFS+KSD+W+FG+L+WEIYS G++PY R    +    + +G ++  P      VY +M
Sbjct: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419

Query: 631 YSCWHEKADERPTFKILLSNILDVMDEE 658
            +CWH  A  RP+F  L   +  +   E
Sbjct: 420 KNCWHLDAAMRPSFLQLREQLEHIKTHE 447


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,947,755
Number of Sequences: 37866
Number of extensions: 1316571
Number of successful extensions: 7523
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 716
Number of HSP's successfully gapped in prelim test: 352
Number of HSP's that attempted gapping in prelim test: 5016
Number of HSP's gapped (non-prelim): 1610
length of query: 659
length of database: 18,247,518
effective HSP length: 109
effective length of query: 550
effective length of database: 14,120,124
effective search space: 7766068200
effective search space used: 7766068200
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.