Search of human proteins with 45439327

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45439327 periplakin [Homo sapiens]
         (1756 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45439327 periplakin [Homo sapiens]                                3393   0.0  
gi|156104874 envoplakin [Homo sapiens]                                832   0.0  
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       413   e-115
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       413   e-115
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        413   e-115
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        413   e-115
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        413   e-115
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        413   e-115
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        413   e-115
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        413   e-115
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]               372   e-102
gi|221316624 dystonin isoform 4 [Homo sapiens]                        311   3e-84
gi|221316622 dystonin isoform 3 [Homo sapiens]                        311   3e-84
gi|221316618 dystonin isoform 2 [Homo sapiens]                        311   3e-84
gi|34577047 dystonin isoform 1 [Homo sapiens]                         311   3e-84
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]             311   3e-84
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]             283   1e-75
gi|33188445 microfilament and actin filament cross-linker protei...   249   1e-65
gi|58530840 desmoplakin isoform I [Homo sapiens]                      247   6e-65
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...   243   2e-63
gi|58530842 desmoplakin isoform II [Homo sapiens]                     224   7e-58
gi|21735548 centrosomal protein 2 [Homo sapiens]                      184   9e-46
gi|148746195 trichohyalin [Homo sapiens]                              169   2e-41
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   165   4e-40
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   165   4e-40
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   165   4e-40
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   165   4e-40
gi|71061468 centromere protein E [Homo sapiens]                       161   5e-39
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   160   1e-38
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    158   5e-38

>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score = 3393 bits (8797), Expect = 0.0
 Identities = 1756/1756 (100%), Positives = 1756/1756 (100%)

Query: 1    MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQ 60
            MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQ
Sbjct: 1    MNSLFRKRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQ 60

Query: 61   EGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGK 120
            EGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGK
Sbjct: 61   EGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGK 120

Query: 121  HKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGP 180
            HKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGP
Sbjct: 121  HKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGP 180

Query: 181  HLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYD 240
            HLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYD
Sbjct: 181  HLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYD 240

Query: 241  WSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHA 300
            WSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHA
Sbjct: 241  WSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHA 300

Query: 301  DWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELL 360
            DWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELL
Sbjct: 301  DWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELL 360

Query: 361  LRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRG 420
            LRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRG
Sbjct: 361  LRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRG 420

Query: 421  YSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGS 480
            YSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGS
Sbjct: 421  YSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGS 480

Query: 481  KRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQ 540
            KRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQ
Sbjct: 481  KRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQ 540

Query: 541  DSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHL 600
            DSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHL
Sbjct: 541  DSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHL 600

Query: 601  LQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMAC 660
            LQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMAC
Sbjct: 601  LQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMAC 660

Query: 661  ELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVER 720
            ELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVER
Sbjct: 661  ELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVER 720

Query: 721  RAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR 780
            RAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR
Sbjct: 721  RAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR 780

Query: 781  EQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEA 840
            EQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEA
Sbjct: 781  EQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEA 840

Query: 841  ALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELD 900
            ALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELD
Sbjct: 841  ALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELD 900

Query: 901  EETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE 960
            EETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE
Sbjct: 901  EETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE 960

Query: 961  QHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEAL 1020
            QHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEAL
Sbjct: 961  QHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEAL 1020

Query: 1021 RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQ 1080
            RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQ
Sbjct: 1021 RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQ 1080

Query: 1081 DQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDE 1140
            DQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDE
Sbjct: 1081 DQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDE 1140

Query: 1141 AAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQER 1200
            AAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQER
Sbjct: 1141 AAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQER 1200

Query: 1201 KYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTR 1260
            KYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTR
Sbjct: 1201 KYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTR 1260

Query: 1261 LIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQK 1320
            LIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQK
Sbjct: 1261 LIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQK 1320

Query: 1321 KQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELR 1380
            KQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELR
Sbjct: 1321 KQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELR 1380

Query: 1381 QIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREK 1440
            QIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREK
Sbjct: 1381 QIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREK 1440

Query: 1441 VTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVV 1500
            VTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVV
Sbjct: 1441 VTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVV 1500

Query: 1501 LSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDF 1560
            LSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDF
Sbjct: 1501 LSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDF 1560

Query: 1561 LREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELD 1620
            LREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELD
Sbjct: 1561 LREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELD 1620

Query: 1621 DLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLI 1680
            DLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLI
Sbjct: 1621 DLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLI 1680

Query: 1681 DWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVN 1740
            DWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVN
Sbjct: 1681 DWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVN 1740

Query: 1741 KDMSIQELAVLVSGQK 1756
            KDMSIQELAVLVSGQK
Sbjct: 1741 KDMSIQELAVLVSGQK 1756


>gi|156104874 envoplakin [Homo sapiens]
          Length = 2033

 Score =  832 bits (2148), Expect = 0.0
 Identities = 538/1778 (30%), Positives = 948/1778 (53%), Gaps = 53/1778 (2%)

Query: 12   KYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVT 71
            K SP+  +R+ + +EL+ LI ++Q NADQVE++I++T+ ++Q D    ++ +  +H+  T
Sbjct: 25   KGSPSRHSRA-ATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQET 83

Query: 72   LQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAV-- 129
             + + ++E LL  L  D   A+ +KHPQ + I +DI+QL ERVT    +++ +Y   V  
Sbjct: 84   GRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLP 143

Query: 130  KEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKE 189
             +V P+V+WA ++E+K  ++    +G  +  ++ Q+ EHNI   E+ A G  L      +
Sbjct: 144  PDVGPRVDWARVLEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQLRSLVGPD 203

Query: 190  QNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYP 249
              + +R++Y+ LL A+  R Q L SL  ++Q CT +L  L +Q +  +Q DWSD   D  
Sbjct: 204  A-ATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDWSDLMADPA 262

Query: 250  SRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLL 309
              RR+YE+F    L ++E+ +N+L  +G++++   HP    I+AH EA+  +W+ +LNL 
Sbjct: 263  GVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKMEWQNFLNLC 322

Query: 310  ICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIEL-LLRELDDQE 368
            IC+E+ L+++EDY +F E+     + L K++S+L+ KY P           LL++L+ +E
Sbjct: 323  ICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPAPGGPPGAPTELLQQLEAEE 382

Query: 369  KVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKN 428
            K L   E     LQ+R + V PL  RR  P +P+ V+++CD++  +  + +G  Y L  N
Sbjct: 383  KRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWDSGEVQLLQGERYKLVDN 442

Query: 429  NG-ESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQR 487
                +W +    G    APA CF IP  DP+A+A A  L S+ ++++QK A    T+Q R
Sbjct: 443  TDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASELQALKQKLA----TVQSR 498

Query: 488  YEVLKTEN---------PGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRA 538
             +    E+           D ++ Q ++LL  + ++  DL + E+ +    R PL +   
Sbjct: 499  LKASAVESLRPSQQAPSGSDLANPQAQKLLTQMTRLDGDLGQIERQVLAWARAPLSRPTP 558

Query: 539  VQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYE 598
            ++D   R    +     L  +  EK  +  E EAF+   P       L   +     K+ 
Sbjct: 559  LEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPAALQLPVALNSVKNKFS 618

Query: 599  HLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAM 658
             +  L  L  EK   A  LE+ +Q +  ++   E  L Q+  +P     L  +  EL   
Sbjct: 619  DVQVLCSLYGEKAKAALDLERQIQDADRVIRGFEATLVQEAPIPAEPGALQERVSELQRQ 678

Query: 659  ACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQV 718
              EL  Q++ +  + + L+A++   + L + FQE C DL RQ+ +V  L  R++ +  Q+
Sbjct: 679  RRELLEQQTCVLRLHRALKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQL 738

Query: 719  ERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIA 778
            + R + +Q A   Y+ F    D++  +L  +P  + + +D  SQ+  KL+ QK L  EI 
Sbjct: 739  DLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQ 798

Query: 779  SREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEE 838
            SRE++       SQ  Q A++DYEL+A+  R    LE   +    KR R+      ++ +
Sbjct: 799  SRERDRATASHLSQALQAALQDYELQADTYRC--SLEPTLAVSAPKRPRVAPLQESIQAQ 856

Query: 839  EAALAAKFTEVYAINRQRLQNLEFALNLLRQQP---EVEVTHETLQRNR-PDSGVEEAWK 894
            E  LA  +TEV A  +Q LQ LEFA  +L ++    ++  TH+  Q +  P     E+  
Sbjct: 857  EKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEA 916

Query: 895  IRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQ 954
            ++ +L+EE +R  ++++E+++ + ++  LR Q P E +  KEV++   DP LE S  +++
Sbjct: 917  LKAQLEEERKRVARVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 976

Query: 955  RTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLR 1014
              + EE  +   LQ +LE    ++  LE + +      + KEV ++E D     +  QLR
Sbjct: 977  AQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLR 1036

Query: 1015 EELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQ 1074
             +++ LR +     A +  L++ + AL + +   +EKV  KEVVK++ + ++    Q L+
Sbjct: 1037 IQIQQLRGEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALR 1096

Query: 1075 EDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLT 1134
               +     R++ EE ++ LQ +++ LE+  +  E K+ VKEV KVE+D    +E S L 
Sbjct: 1097 LQMEEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLR 1156

Query: 1135 RQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLE 1194
               E+E  K     RE ++L  K   +E++  KV +QE+V EI + DP+ E E+  L+ +
Sbjct: 1157 SLLEEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAK 1216

Query: 1195 LVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREE 1254
            L E   K  G E+++     +LE LR + P VE KEVT+EV++++  PE+ +E+ RL+ +
Sbjct: 1217 LQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLKAQ 1276

Query: 1255 IVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAK 1314
            + +      R   ++ +L+ E    +  + +V+TK V +E+++ ++DP  ++E   LR +
Sbjct: 1277 LNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLRQE 1336

Query: 1315 LSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAES 1374
            + E  +K+     E A  E Q  R   E  + +E+VV QEVV  +++P LR E S  + S
Sbjct: 1337 VREAAQKR--RAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEHSRLSGS 1394

Query: 1375 IDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEE 1434
            +D E+ +  +L  E+++L R   E +  L   + +R  +   ERE+++L  R+  LE+  
Sbjct: 1395 LDEEVGRRRQLELEVQQL-RAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRP 1453

Query: 1435 AEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAE 1494
               +EK+   + V L++DP   +    LR  L++E+ +   L  E + L+ ++  L+KA+
Sbjct: 1454 PTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDVLQKAK 1513

Query: 1495 VKEKVVLSESVQVEKGDT-EQEIQRLKSSLEEESRSKRELDVEVSRLEARL--------- 1544
             +EK +  E ++V+K    E E  R+   L  E  +++  + E  RL  R+         
Sbjct: 1514 SQEKTIYKEVIRVQKDRVLEDERARVWEMLNRERTARQAREEEARRLRERIDRAETLGRT 1573

Query: 1545 -----SELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNM 1599
                 SEL+    ++ +E   L++E   L+ ++Q    +T +LQ E  + + +T   R  
Sbjct: 1574 WSREESELQRARDQADQECGRLQQELRALERQKQQ---QTLQLQEESKLLSQKTESER-Q 1629

Query: 1600 TVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKRE--QRENHLRRS 1657
              A  G        ++ RE D +     +K+  + +L  ++    + +E   RE +L   
Sbjct: 1630 KAAQRGQELSRLEAAILREKDQI----YEKERTLRDLHAKVSREELSQETQTRETNLSTK 1685

Query: 1658 IVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGK 1717
            I ++ P+TG+++SP EA++ G+ID   +++L+  ECDWEE++  GP GE SV+ DRKSGK
Sbjct: 1686 ISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEESVLLDRKSGK 1745

Query: 1718 KFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQ 1755
            ++SIE AL+  R++  +Y  Y +  + I E A+LV+G+
Sbjct: 1746 QYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGE 1783


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  413 bits (1062), Expect = e-115
 Identities = 426/1763 (24%), Positives = 785/1763 (44%), Gaps = 218/1763 (12%)

Query: 27   LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86
            L  ++ +LQ  A   E+ +   +A +QSD+  L  G+ P+      + +  ++ ++ +L 
Sbjct: 394  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 453

Query: 87   ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK------------QIYRLAVKEVD- 133
             D    K  +HPQG+ +   + +L ER+  +R ++             Q+ ++ ++ V  
Sbjct: 454  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 513

Query: 134  -PQVNWAAL---------VEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLA 183
             P++  + L         VEE   +++   +G DLP V+ Q+  H   H  ++     + 
Sbjct: 514  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 573

Query: 184  KDGDKEQN-------------SELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD 230
            +    E                 L  +Y KLL +S+AR + L SL  ++   T EL WL+
Sbjct: 574  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 633

Query: 231  QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290
            ++ +  + +DWSDRN +  +++  Y   + R LE KE++I +L + GD+LL  +HP R +
Sbjct: 634  EKEEEEVGFDWSDRNTNMTAKKESYSALM-RELELKEKKIKELQNAGDRLLREDHPARPT 692

Query: 291  IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD 350
            +E+   A+   W   L L  C E+HLK    Y QF  DV++A+  L+K+   L +KY  D
Sbjct: 693  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 752

Query: 351  FKDRY-QIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-PLKP-IPVEAL 407
                  ++E LL++  D+++ L++Y+  + GL KR + VV LK R    P++  +P+ A+
Sbjct: 753  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 812

Query: 408  CDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPP------------ 454
            CD++  +  + +G    L      S W+++ S+G++   P+VCF++PP            
Sbjct: 813  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 872

Query: 455  ---------------TDPEALALADSLGSQYRSVRQKAAGSKRTL---QQRYEVLKTENP 496
                            D ++L    SL    + +R  +  + RTL   +QR  +   E  
Sbjct: 873  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 932

Query: 497  -----GDASDLQG--------------------RQLLAGLDKVASDLDRQEKAITGI--- 528
                  D+ D  G                    +QLL  L++ A +  R ++ I+ +   
Sbjct: 933  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 992

Query: 529  --------------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI 574
                          LR PL++  A ++ A+R  + +    E+  +     R +AE E  +
Sbjct: 993  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1051

Query: 575  QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH 634
                 S   P LR+ +E T  K E +  L  +  EK+   + + +  Q + E+L  HE  
Sbjct: 1052 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1111

Query: 635  LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC 694
            L +   VP +   L++    L  +  + +AQ+     +   L+ A++    L  R  E  
Sbjct: 1112 LKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171

Query: 695  PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEP 754
             ++ER    V +L +R+  +  Q + R + L+       ++    D +  +L      + 
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1231

Query: 755  Q-----ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLR 809
            Q       DS +  E +L+ ++ LL+EI    ++V++    ++QY  A+KDYEL+    +
Sbjct: 1232 QIQAMPLADSQAVRE-QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1290

Query: 810  SLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQ 869
            + L+      +  +K+ ++QS +  V +E   L   ++E+  +  Q ++ +   L  + +
Sbjct: 1291 AQLE----PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1346

Query: 870  QPEVEVTHETLQRNRPDSGVEEAWKIRKELDE-ETERRRQLENEVKSTQEEIWTLRNQGP 928
            +  +       +R R  + VE A + +++L E   + + Q E E K  Q+ +        
Sbjct: 1347 EERLAEQQRAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-------- 1397

Query: 929  QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988
            QE VVR+E                      + Q + + +QEEL+ L+ Q    E + +  
Sbjct: 1398 QEEVVRRE------------------EAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKAR 1438

Query: 989  GQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRA 1048
              E   +  LRIE      +E+  +R +LEA  RQ+G  E E+  L+ R      E++ A
Sbjct: 1439 QAEAAERSRLRIE------EEIRVVRLQLEATERQRGGAEGELQALRARA-----EEAEA 1487

Query: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDK---LKRLEKER 1105
            Q++  ++E  +L+   Q E+     Q   Q + +L  + + E    ++K   L+ LE+ R
Sbjct: 1488 QKRQAQEEAERLRRQVQDES-----QRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542

Query: 1106 AMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEEN 1165
              AE         +VE+    +  +    R  E E    RAS  EKT  L +  +L+EE+
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--SLQEEH 1600

Query: 1166 AKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSEL-EALRRRGP 1224
              V    ++RE          E      +  E ER    AE +L  +Q +  EALR R  
Sbjct: 1601 VAVA---QLRE----------EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647

Query: 1225 QVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
              EV +  K + + + + + E+  +  R     + + + + +L   +L+K+ Q  + T  
Sbjct: 1648 AEEVAQ-QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706

Query: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
            Q    E  QE+++ + + +  E+    + +L EE+  ++  E   A+Q+ Q    E    
Sbjct: 1707 QRLAAE--QELIRLRAETEQGEQ----QRQLLEEELARLQREAAAATQKRQELEAELAKV 1760

Query: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
            R +  V+     R EEE    +E S   + ++ E  +  +L  E  RL+    E +RQ  
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQ-R 1817

Query: 1405 ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRL 1464
            +L  E  AR+ AE E + L ++LAA+     EA    T  +  + +++ +  R   L RL
Sbjct: 1818 QLAEEDAARQRAEAE-RVLAEKLAAI----GEATRLKTEAEIALKEKEAENER---LRRL 1869

Query: 1465 QLEEEQHRRQLLEGELE---TLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518
              +E   RR+L E   +    +  +LA L KA   E++ +  L E    ++   E+EI  
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929

Query: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578
            LK+S E+ +  K EL++E+ R+ +   +     SK   EL+  R+     + ER+  + E
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDT--LRSKEQAELEAARQRQLAAEEERRRREAE 1987

Query: 1579 TR---RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDE 1635
             R    L +E   A      L  +    +      RL     E +  ++L   ++     
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE-RAEQESARQLQLAQEAAQKR 2046

Query: 1636 LQKRLGSVAVKREQRENHLRRSI 1658
            LQ    + A   +Q+E  L++++
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTL 2069



 Score =  187 bits (476), Expect = 6e-47
 Identities = 333/1478 (22%), Positives = 606/1478 (41%), Gaps = 254/1478 (17%)

Query: 475  QKAAGSKRTLQQRYEVLKTENPGDASDLQGR--QLLAGLDKVASDLDRQEKAITGILRPP 532
            + A   +R L + +   K +   +A +LQ R  + +   ++ A D  +Q+++I   L+  
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425

Query: 533  LEQGRAVQDSAERAKDLKNITNELLRIEPE------------KTRSTAEGE--------- 571
             +   A  +   +A+  +      LRIE E            + R  AEGE         
Sbjct: 1426 RQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1483

Query: 572  -AFIQALPGSGTTPLLRTRVED-TNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWEL-- 627
             A  Q          LR +V+D + RK +  ++L    + + + A   +++LQ   EL  
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543

Query: 628  -LATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTL 686
                 E  L Q + V  + +V  +      +   ELQ++++   E    L+ + Q     
Sbjct: 1544 QAEEAERRLRQAE-VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602

Query: 687  ASRFQEHCPDLERQEAEVHKLGQRFNN--------------LRQQVERRAQSLQSAKAAY 732
             ++ +E      +Q+AE  +  +                  LR Q E  AQ    A+A  
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662

Query: 733  EHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR----EQEVQKIC 788
            E   +  +   +        E Q        E +L+ Q+ L +  A +    EQE+ ++ 
Sbjct: 1663 E---KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719

Query: 789  ANSQQYQQ-------------------AVKDYELEAEKLRSLLDLENGRSSHVSKRARLQ 829
            A ++Q +Q                     K  ELEAE  +   ++E   +S        +
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779

Query: 830  SPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNR----P 885
            S + K K+   A A +F E+ A    RL+ L       RQ  E +   +  +  R     
Sbjct: 1780 STSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1838

Query: 886  DSGVEEAWKIR-------KELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVL 938
             + + EA +++       KE + E ER R+L  +    +  +     Q   +   R   L
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898

Query: 939  KKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVL 998
            +K  D  LE     ++ TL + +     ++EE+ AL+        E    G+  +  E+ 
Sbjct: 1899 RKASDSELERQKGLVEDTLRQRRQ----VEEEILALKASF-----EKAAAGKAELELELG 1949

Query: 999  RIEPDRAQADEVLQLRE--ELEALRRQKGARE-----------------AEVLLLQQRVA 1039
            RI   R+ A++ L+ +E  ELEA R+++ A E                 AE    +QR A
Sbjct: 1950 RI---RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006

Query: 1040 ALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK--------QEEEL 1091
            AL EE  R + KV E   ++ + + +   + Q  QE  Q++ Q  EK        +E+EL
Sbjct: 2007 AL-EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065

Query: 1092 S-FLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE 1150
               LQ +   L++ R  AE      E  + E     ERE +   RQ E EA + + S  E
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVE-EAERLKQSAEE 2123

Query: 1151 KTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLR 1210
            + +   +  A  E+  K   QE  R       +A++E A LR +        + A+ ++ 
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAAR-------RAQAEQAALRQK--------QAADAEME 2168

Query: 1211 SYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE---MEKELQRLREEIVDKTRLIERCDL 1267
             ++   E   R+  QVE +  T  +   +TD +   +++ELQRL+ E  +  R   + + 
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2228

Query: 1268 EIYQLKKEIQALKDTKPQVQT---------KEVVQEILQFQEDP--QTKEEVASLRAKLS 1316
            E++ ++ +++ L   K +++          K+  Q  LQ + +   Q  EE A L     
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2288

Query: 1317 E----EQKKQVDLERERASQEEQIARK------------EEELSRVKERVVQQEVVRYEE 1360
            E     Q  + DL ++RA  E+ +  K            E EL + ++ + Q++  R +E
Sbjct: 2289 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2348

Query: 1361 EPG-----LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQA--- 1412
            +       L  E   F  +++ E ++  ++ AE  RL+ R  E+ R     E + Q    
Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408

Query: 1413 -----------------------------RREAEREVQRLQQRLAALEQEEAEAREKVTH 1443
                                         R++++ + +RL++ +A LE+E+ + +++   
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468

Query: 1444 TQKVVLQQDPQQAREHALLR----LQLEEEQHRRQLLEGE--LETLRRKLAALEKAEVKE 1497
             Q  +  ++ Q  ++  LL+    LQ      +  LL+ E  +E  + KL  L + EV +
Sbjct: 2469 LQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2526

Query: 1498 KVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKE 1557
               L E  Q ++   EQE QRL +S+EE  R + E +  V R +  L +LE    +  ++
Sbjct: 2527 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE---QQRRQQ 2583

Query: 1558 LDFLREENHKLQLERQNLQLETRRLQSE------INMAATET----RDLRNMTVADSGTN 1607
             + L EEN +L+ + Q L+ + R   +         +AAT+T    RD  +   A++   
Sbjct: 2584 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643

Query: 1608 HDSRLWSLERELDDLKRLSKDKDLEIDELQK-RLGSVAV----KREQRENHL--RRSIV- 1659
            H      L R++   +RL +   L  +ELQ+   G   V    +RE   ++L  R SI  
Sbjct: 2644 HS--FDGLRRKV-SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG 2700

Query: 1660 VIHPDTGRELSPEEA-HRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKK 1718
            ++   T  +LS   A  R  L      + L +Q               S  + D    ++
Sbjct: 2701 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQ-------------AASGFLLDPVRNRR 2747

Query: 1719 FSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK 1756
             ++ EA++ G + P  + + ++ + ++       +GQ+
Sbjct: 2748 LTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQ 2785



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 40/110 (36%), Positives = 71/110 (64%), Gaps = 1/110 (0%)

Query: 1646 KREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNG 1705
            K   + +  +R +V++ P+TG+E+S  EA+R GLID   +++L  QEC+WEEI++   +G
Sbjct: 4129 KTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDG 4188

Query: 1706 -ESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSG 1754
               S+I DR+SG+++ I++A+    +  +  D+Y    +SI E A ++SG
Sbjct: 4189 VVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4238


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  413 bits (1062), Expect = e-115
 Identities = 426/1763 (24%), Positives = 785/1763 (44%), Gaps = 218/1763 (12%)

Query: 27   LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86
            L  ++ +LQ  A   E+ +   +A +QSD+  L  G+ P+      + +  ++ ++ +L 
Sbjct: 398  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 457

Query: 87   ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK------------QIYRLAVKEVD- 133
             D    K  +HPQG+ +   + +L ER+  +R ++             Q+ ++ ++ V  
Sbjct: 458  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 517

Query: 134  -PQVNWAAL---------VEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLA 183
             P++  + L         VEE   +++   +G DLP V+ Q+  H   H  ++     + 
Sbjct: 518  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 577

Query: 184  KDGDKEQN-------------SELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD 230
            +    E                 L  +Y KLL +S+AR + L SL  ++   T EL WL+
Sbjct: 578  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 637

Query: 231  QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290
            ++ +  + +DWSDRN +  +++  Y   + R LE KE++I +L + GD+LL  +HP R +
Sbjct: 638  EKEEEEVGFDWSDRNTNMTAKKESYSALM-RELELKEKKIKELQNAGDRLLREDHPARPT 696

Query: 291  IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD 350
            +E+   A+   W   L L  C E+HLK    Y QF  DV++A+  L+K+   L +KY  D
Sbjct: 697  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 756

Query: 351  FKDRY-QIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-PLKP-IPVEAL 407
                  ++E LL++  D+++ L++Y+  + GL KR + VV LK R    P++  +P+ A+
Sbjct: 757  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 816

Query: 408  CDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPP------------ 454
            CD++  +  + +G    L      S W+++ S+G++   P+VCF++PP            
Sbjct: 817  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 876

Query: 455  ---------------TDPEALALADSLGSQYRSVRQKAAGSKRTL---QQRYEVLKTENP 496
                            D ++L    SL    + +R  +  + RTL   +QR  +   E  
Sbjct: 877  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 936

Query: 497  -----GDASDLQG--------------------RQLLAGLDKVASDLDRQEKAITGI--- 528
                  D+ D  G                    +QLL  L++ A +  R ++ I+ +   
Sbjct: 937  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 996

Query: 529  --------------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI 574
                          LR PL++  A ++ A+R  + +    E+  +     R +AE E  +
Sbjct: 997  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1055

Query: 575  QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH 634
                 S   P LR+ +E T  K E +  L  +  EK+   + + +  Q + E+L  HE  
Sbjct: 1056 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1115

Query: 635  LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC 694
            L +   VP +   L++    L  +  + +AQ+     +   L+ A++    L  R  E  
Sbjct: 1116 LKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1175

Query: 695  PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEP 754
             ++ER    V +L +R+  +  Q + R + L+       ++    D +  +L      + 
Sbjct: 1176 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1235

Query: 755  Q-----ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLR 809
            Q       DS +  E +L+ ++ LL+EI    ++V++    ++QY  A+KDYEL+    +
Sbjct: 1236 QIQAMPLADSQAVRE-QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1294

Query: 810  SLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQ 869
            + L+      +  +K+ ++QS +  V +E   L   ++E+  +  Q ++ +   L  + +
Sbjct: 1295 AQLE----PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1350

Query: 870  QPEVEVTHETLQRNRPDSGVEEAWKIRKELDE-ETERRRQLENEVKSTQEEIWTLRNQGP 928
            +  +       +R R  + VE A + +++L E   + + Q E E K  Q+ +        
Sbjct: 1351 EERLAEQQRAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-------- 1401

Query: 929  QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988
            QE VVR+E                      + Q + + +QEEL+ L+ Q    E + +  
Sbjct: 1402 QEEVVRRE------------------EAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKAR 1442

Query: 989  GQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRA 1048
              E   +  LRIE      +E+  +R +LEA  RQ+G  E E+  L+ R      E++ A
Sbjct: 1443 QAEAAERSRLRIE------EEIRVVRLQLEATERQRGGAEGELQALRARA-----EEAEA 1491

Query: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDK---LKRLEKER 1105
            Q++  ++E  +L+   Q E+     Q   Q + +L  + + E    ++K   L+ LE+ R
Sbjct: 1492 QKRQAQEEAERLRRQVQDES-----QRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1546

Query: 1106 AMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEEN 1165
              AE         +VE+    +  +    R  E E    RAS  EKT  L +  +L+EE+
Sbjct: 1547 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--SLQEEH 1604

Query: 1166 AKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSEL-EALRRRGP 1224
              V    ++RE          E      +  E ER    AE +L  +Q +  EALR R  
Sbjct: 1605 VAVA---QLRE----------EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651

Query: 1225 QVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
              EV +  K + + + + + E+  +  R     + + + + +L   +L+K+ Q  + T  
Sbjct: 1652 AEEVAQ-QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1710

Query: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
            Q    E  QE+++ + + +  E+    + +L EE+  ++  E   A+Q+ Q    E    
Sbjct: 1711 QRLAAE--QELIRLRAETEQGEQ----QRQLLEEELARLQREAAAATQKRQELEAELAKV 1764

Query: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
            R +  V+     R EEE    +E S   + ++ E  +  +L  E  RL+    E +RQ  
Sbjct: 1765 RAEMEVLLASKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQ-R 1821

Query: 1405 ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRL 1464
            +L  E  AR+ AE E + L ++LAA+     EA    T  +  + +++ +  R   L RL
Sbjct: 1822 QLAEEDAARQRAEAE-RVLAEKLAAI----GEATRLKTEAEIALKEKEAENER---LRRL 1873

Query: 1465 QLEEEQHRRQLLEGELE---TLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518
              +E   RR+L E   +    +  +LA L KA   E++ +  L E    ++   E+EI  
Sbjct: 1874 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1933

Query: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578
            LK+S E+ +  K EL++E+ R+ +   +     SK   EL+  R+     + ER+  + E
Sbjct: 1934 LKASFEKAAAGKAELELELGRIRSNAEDT--LRSKEQAELEAARQRQLAAEEERRRREAE 1991

Query: 1579 TR---RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDE 1635
             R    L +E   A      L  +    +      RL     E +  ++L   ++     
Sbjct: 1992 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE-RAEQESARQLQLAQEAAQKR 2050

Query: 1636 LQKRLGSVAVKREQRENHLRRSI 1658
            LQ    + A   +Q+E  L++++
Sbjct: 2051 LQAEEKAHAFAVQQKEQELQQTL 2073



 Score =  187 bits (476), Expect = 6e-47
 Identities = 333/1478 (22%), Positives = 606/1478 (41%), Gaps = 254/1478 (17%)

Query: 475  QKAAGSKRTLQQRYEVLKTENPGDASDLQGR--QLLAGLDKVASDLDRQEKAITGILRPP 532
            + A   +R L + +   K +   +A +LQ R  + +   ++ A D  +Q+++I   L+  
Sbjct: 1370 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1429

Query: 533  LEQGRAVQDSAERAKDLKNITNELLRIEPE------------KTRSTAEGE--------- 571
             +   A  +   +A+  +      LRIE E            + R  AEGE         
Sbjct: 1430 RQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1487

Query: 572  -AFIQALPGSGTTPLLRTRVED-TNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWEL-- 627
             A  Q          LR +V+D + RK +  ++L    + + + A   +++LQ   EL  
Sbjct: 1488 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1547

Query: 628  -LATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTL 686
                 E  L Q + V  + +V  +      +   ELQ++++   E    L+ + Q     
Sbjct: 1548 QAEEAERRLRQAE-VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1606

Query: 687  ASRFQEHCPDLERQEAEVHKLGQRFNN--------------LRQQVERRAQSLQSAKAAY 732
             ++ +E      +Q+AE  +  +                  LR Q E  AQ    A+A  
Sbjct: 1607 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1666

Query: 733  EHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR----EQEVQKIC 788
            E   +  +   +        E Q        E +L+ Q+ L +  A +    EQE+ ++ 
Sbjct: 1667 E---KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1723

Query: 789  ANSQQYQQ-------------------AVKDYELEAEKLRSLLDLENGRSSHVSKRARLQ 829
            A ++Q +Q                     K  ELEAE  +   ++E   +S        +
Sbjct: 1724 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783

Query: 830  SPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNR----P 885
            S + K K+   A A +F E+ A    RL+ L       RQ  E +   +  +  R     
Sbjct: 1784 STSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1842

Query: 886  DSGVEEAWKIR-------KELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVL 938
             + + EA +++       KE + E ER R+L  +    +  +     Q   +   R   L
Sbjct: 1843 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1902

Query: 939  KKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVL 998
            +K  D  LE     ++ TL + +     ++EE+ AL+        E    G+  +  E+ 
Sbjct: 1903 RKASDSELERQKGLVEDTLRQRRQ----VEEEILALKASF-----EKAAAGKAELELELG 1953

Query: 999  RIEPDRAQADEVLQLRE--ELEALRRQKGARE-----------------AEVLLLQQRVA 1039
            RI   R+ A++ L+ +E  ELEA R+++ A E                 AE    +QR A
Sbjct: 1954 RI---RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2010

Query: 1040 ALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK--------QEEEL 1091
            AL EE  R + KV E   ++ + + +   + Q  QE  Q++ Q  EK        +E+EL
Sbjct: 2011 AL-EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2069

Query: 1092 S-FLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE 1150
               LQ +   L++ R  AE      E  + E     ERE +   RQ E EA + + S  E
Sbjct: 2070 QQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVE-EAERLKQSAEE 2127

Query: 1151 KTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLR 1210
            + +   +  A  E+  K   QE  R       +A++E A LR +        + A+ ++ 
Sbjct: 2128 QAQARAQAQAAAEKLRKEAEQEAAR-------RAQAEQAALRQK--------QAADAEME 2172

Query: 1211 SYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE---MEKELQRLREEIVDKTRLIERCDL 1267
             ++   E   R+  QVE +  T  +   +TD +   +++ELQRL+ E  +  R   + + 
Sbjct: 2173 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2232

Query: 1268 EIYQLKKEIQALKDTKPQVQT---------KEVVQEILQFQEDP--QTKEEVASLRAKLS 1316
            E++ ++ +++ L   K +++          K+  Q  LQ + +   Q  EE A L     
Sbjct: 2233 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2292

Query: 1317 E----EQKKQVDLERERASQEEQIARK------------EEELSRVKERVVQQEVVRYEE 1360
            E     Q  + DL ++RA  E+ +  K            E EL + ++ + Q++  R +E
Sbjct: 2293 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2352

Query: 1361 EPG-----LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQA--- 1412
            +       L  E   F  +++ E ++  ++ AE  RL+ R  E+ R     E + Q    
Sbjct: 2353 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2412

Query: 1413 -----------------------------RREAEREVQRLQQRLAALEQEEAEAREKVTH 1443
                                         R++++ + +RL++ +A LE+E+ + +++   
Sbjct: 2413 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2472

Query: 1444 TQKVVLQQDPQQAREHALLR----LQLEEEQHRRQLLEGE--LETLRRKLAALEKAEVKE 1497
             Q  +  ++ Q  ++  LL+    LQ      +  LL+ E  +E  + KL  L + EV +
Sbjct: 2473 LQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2530

Query: 1498 KVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKE 1557
               L E  Q ++   EQE QRL +S+EE  R + E +  V R +  L +LE    +  ++
Sbjct: 2531 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE---QQRRQQ 2587

Query: 1558 LDFLREENHKLQLERQNLQLETRRLQSE------INMAATET----RDLRNMTVADSGTN 1607
             + L EEN +L+ + Q L+ + R   +         +AAT+T    RD  +   A++   
Sbjct: 2588 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2647

Query: 1608 HDSRLWSLERELDDLKRLSKDKDLEIDELQK-RLGSVAV----KREQRENHL--RRSIV- 1659
            H      L R++   +RL +   L  +ELQ+   G   V    +RE   ++L  R SI  
Sbjct: 2648 HS--FDGLRRKV-SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG 2704

Query: 1660 VIHPDTGRELSPEEA-HRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKK 1718
            ++   T  +LS   A  R  L      + L +Q               S  + D    ++
Sbjct: 2705 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQ-------------AASGFLLDPVRNRR 2751

Query: 1719 FSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK 1756
             ++ EA++ G + P  + + ++ + ++       +GQ+
Sbjct: 2752 LTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQ 2789



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 40/110 (36%), Positives = 71/110 (64%), Gaps = 1/110 (0%)

Query: 1646 KREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNG 1705
            K   + +  +R +V++ P+TG+E+S  EA+R GLID   +++L  QEC+WEEI++   +G
Sbjct: 4133 KTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDG 4192

Query: 1706 -ESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSG 1754
               S+I DR+SG+++ I++A+    +  +  D+Y    +SI E A ++SG
Sbjct: 4193 VVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4242


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  413 bits (1062), Expect = e-115
 Identities = 426/1763 (24%), Positives = 785/1763 (44%), Gaps = 218/1763 (12%)

Query: 27   LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86
            L  ++ +LQ  A   E+ +   +A +QSD+  L  G+ P+      + +  ++ ++ +L 
Sbjct: 394  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 453

Query: 87   ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK------------QIYRLAVKEVD- 133
             D    K  +HPQG+ +   + +L ER+  +R ++             Q+ ++ ++ V  
Sbjct: 454  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 513

Query: 134  -PQVNWAAL---------VEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLA 183
             P++  + L         VEE   +++   +G DLP V+ Q+  H   H  ++     + 
Sbjct: 514  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 573

Query: 184  KDGDKEQN-------------SELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD 230
            +    E                 L  +Y KLL +S+AR + L SL  ++   T EL WL+
Sbjct: 574  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 633

Query: 231  QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290
            ++ +  + +DWSDRN +  +++  Y   + R LE KE++I +L + GD+LL  +HP R +
Sbjct: 634  EKEEEEVGFDWSDRNTNMTAKKESYSALM-RELELKEKKIKELQNAGDRLLREDHPARPT 692

Query: 291  IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD 350
            +E+   A+   W   L L  C E+HLK    Y QF  DV++A+  L+K+   L +KY  D
Sbjct: 693  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 752

Query: 351  FKDRY-QIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-PLKP-IPVEAL 407
                  ++E LL++  D+++ L++Y+  + GL KR + VV LK R    P++  +P+ A+
Sbjct: 753  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 812

Query: 408  CDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPP------------ 454
            CD++  +  + +G    L      S W+++ S+G++   P+VCF++PP            
Sbjct: 813  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 872

Query: 455  ---------------TDPEALALADSLGSQYRSVRQKAAGSKRTL---QQRYEVLKTENP 496
                            D ++L    SL    + +R  +  + RTL   +QR  +   E  
Sbjct: 873  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 932

Query: 497  -----GDASDLQG--------------------RQLLAGLDKVASDLDRQEKAITGI--- 528
                  D+ D  G                    +QLL  L++ A +  R ++ I+ +   
Sbjct: 933  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 992

Query: 529  --------------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI 574
                          LR PL++  A ++ A+R  + +    E+  +     R +AE E  +
Sbjct: 993  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1051

Query: 575  QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH 634
                 S   P LR+ +E T  K E +  L  +  EK+   + + +  Q + E+L  HE  
Sbjct: 1052 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1111

Query: 635  LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC 694
            L +   VP +   L++    L  +  + +AQ+     +   L+ A++    L  R  E  
Sbjct: 1112 LKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171

Query: 695  PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEP 754
             ++ER    V +L +R+  +  Q + R + L+       ++    D +  +L      + 
Sbjct: 1172 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1231

Query: 755  Q-----ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLR 809
            Q       DS +  E +L+ ++ LL+EI    ++V++    ++QY  A+KDYEL+    +
Sbjct: 1232 QIQAMPLADSQAVRE-QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1290

Query: 810  SLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQ 869
            + L+      +  +K+ ++QS +  V +E   L   ++E+  +  Q ++ +   L  + +
Sbjct: 1291 AQLE----PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1346

Query: 870  QPEVEVTHETLQRNRPDSGVEEAWKIRKELDE-ETERRRQLENEVKSTQEEIWTLRNQGP 928
            +  +       +R R  + VE A + +++L E   + + Q E E K  Q+ +        
Sbjct: 1347 EERLAEQQRAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-------- 1397

Query: 929  QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988
            QE VVR+E                      + Q + + +QEEL+ L+ Q    E + +  
Sbjct: 1398 QEEVVRRE------------------EAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKAR 1438

Query: 989  GQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRA 1048
              E   +  LRIE      +E+  +R +LEA  RQ+G  E E+  L+ R      E++ A
Sbjct: 1439 QAEAAERSRLRIE------EEIRVVRLQLEATERQRGGAEGELQALRARA-----EEAEA 1487

Query: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDK---LKRLEKER 1105
            Q++  ++E  +L+   Q E+     Q   Q + +L  + + E    ++K   L+ LE+ R
Sbjct: 1488 QKRQAQEEAERLRRQVQDES-----QRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542

Query: 1106 AMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEEN 1165
              AE         +VE+    +  +    R  E E    RAS  EKT  L +  +L+EE+
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--SLQEEH 1600

Query: 1166 AKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSEL-EALRRRGP 1224
              V    ++RE          E      +  E ER    AE +L  +Q +  EALR R  
Sbjct: 1601 VAVA---QLRE----------EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647

Query: 1225 QVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
              EV +  K + + + + + E+  +  R     + + + + +L   +L+K+ Q  + T  
Sbjct: 1648 AEEVAQ-QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1706

Query: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
            Q    E  QE+++ + + +  E+    + +L EE+  ++  E   A+Q+ Q    E    
Sbjct: 1707 QRLAAE--QELIRLRAETEQGEQ----QRQLLEEELARLQREAAAATQKRQELEAELAKV 1760

Query: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
            R +  V+     R EEE    +E S   + ++ E  +  +L  E  RL+    E +RQ  
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQ-R 1817

Query: 1405 ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRL 1464
            +L  E  AR+ AE E + L ++LAA+     EA    T  +  + +++ +  R   L RL
Sbjct: 1818 QLAEEDAARQRAEAE-RVLAEKLAAI----GEATRLKTEAEIALKEKEAENER---LRRL 1869

Query: 1465 QLEEEQHRRQLLEGELE---TLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518
              +E   RR+L E   +    +  +LA L KA   E++ +  L E    ++   E+EI  
Sbjct: 1870 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1929

Query: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578
            LK+S E+ +  K EL++E+ R+ +   +     SK   EL+  R+     + ER+  + E
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDT--LRSKEQAELEAARQRQLAAEEERRRREAE 1987

Query: 1579 TR---RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDE 1635
             R    L +E   A      L  +    +      RL     E +  ++L   ++     
Sbjct: 1988 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE-RAEQESARQLQLAQEAAQKR 2046

Query: 1636 LQKRLGSVAVKREQRENHLRRSI 1658
            LQ    + A   +Q+E  L++++
Sbjct: 2047 LQAEEKAHAFAVQQKEQELQQTL 2069



 Score =  187 bits (476), Expect = 6e-47
 Identities = 333/1478 (22%), Positives = 606/1478 (41%), Gaps = 254/1478 (17%)

Query: 475  QKAAGSKRTLQQRYEVLKTENPGDASDLQGR--QLLAGLDKVASDLDRQEKAITGILRPP 532
            + A   +R L + +   K +   +A +LQ R  + +   ++ A D  +Q+++I   L+  
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425

Query: 533  LEQGRAVQDSAERAKDLKNITNELLRIEPE------------KTRSTAEGE--------- 571
             +   A  +   +A+  +      LRIE E            + R  AEGE         
Sbjct: 1426 RQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1483

Query: 572  -AFIQALPGSGTTPLLRTRVED-TNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWEL-- 627
             A  Q          LR +V+D + RK +  ++L    + + + A   +++LQ   EL  
Sbjct: 1484 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1543

Query: 628  -LATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTL 686
                 E  L Q + V  + +V  +      +   ELQ++++   E    L+ + Q     
Sbjct: 1544 QAEEAERRLRQAE-VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1602

Query: 687  ASRFQEHCPDLERQEAEVHKLGQRFNN--------------LRQQVERRAQSLQSAKAAY 732
             ++ +E      +Q+AE  +  +                  LR Q E  AQ    A+A  
Sbjct: 1603 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1662

Query: 733  EHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR----EQEVQKIC 788
            E   +  +   +        E Q        E +L+ Q+ L +  A +    EQE+ ++ 
Sbjct: 1663 E---KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719

Query: 789  ANSQQYQQ-------------------AVKDYELEAEKLRSLLDLENGRSSHVSKRARLQ 829
            A ++Q +Q                     K  ELEAE  +   ++E   +S        +
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779

Query: 830  SPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNR----P 885
            S + K K+   A A +F E+ A    RL+ L       RQ  E +   +  +  R     
Sbjct: 1780 STSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1838

Query: 886  DSGVEEAWKIR-------KELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVL 938
             + + EA +++       KE + E ER R+L  +    +  +     Q   +   R   L
Sbjct: 1839 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898

Query: 939  KKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVL 998
            +K  D  LE     ++ TL + +     ++EE+ AL+        E    G+  +  E+ 
Sbjct: 1899 RKASDSELERQKGLVEDTLRQRRQ----VEEEILALKASF-----EKAAAGKAELELELG 1949

Query: 999  RIEPDRAQADEVLQLRE--ELEALRRQKGARE-----------------AEVLLLQQRVA 1039
            RI   R+ A++ L+ +E  ELEA R+++ A E                 AE    +QR A
Sbjct: 1950 RI---RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006

Query: 1040 ALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK--------QEEEL 1091
            AL EE  R + KV E   ++ + + +   + Q  QE  Q++ Q  EK        +E+EL
Sbjct: 2007 AL-EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065

Query: 1092 S-FLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE 1150
               LQ +   L++ R  AE      E  + E     ERE +   RQ E EA + + S  E
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVE-EAERLKQSAEE 2123

Query: 1151 KTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLR 1210
            + +   +  A  E+  K   QE  R       +A++E A LR +        + A+ ++ 
Sbjct: 2124 QAQARAQAQAAAEKLRKEAEQEAAR-------RAQAEQAALRQK--------QAADAEME 2168

Query: 1211 SYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE---MEKELQRLREEIVDKTRLIERCDL 1267
             ++   E   R+  QVE +  T  +   +TD +   +++ELQRL+ E  +  R   + + 
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2228

Query: 1268 EIYQLKKEIQALKDTKPQVQT---------KEVVQEILQFQEDP--QTKEEVASLRAKLS 1316
            E++ ++ +++ L   K +++          K+  Q  LQ + +   Q  EE A L     
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2288

Query: 1317 E----EQKKQVDLERERASQEEQIARK------------EEELSRVKERVVQQEVVRYEE 1360
            E     Q  + DL ++RA  E+ +  K            E EL + ++ + Q++  R +E
Sbjct: 2289 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2348

Query: 1361 EPG-----LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQA--- 1412
            +       L  E   F  +++ E ++  ++ AE  RL+ R  E+ R     E + Q    
Sbjct: 2349 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2408

Query: 1413 -----------------------------RREAEREVQRLQQRLAALEQEEAEAREKVTH 1443
                                         R++++ + +RL++ +A LE+E+ + +++   
Sbjct: 2409 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2468

Query: 1444 TQKVVLQQDPQQAREHALLR----LQLEEEQHRRQLLEGE--LETLRRKLAALEKAEVKE 1497
             Q  +  ++ Q  ++  LL+    LQ      +  LL+ E  +E  + KL  L + EV +
Sbjct: 2469 LQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2526

Query: 1498 KVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKE 1557
               L E  Q ++   EQE QRL +S+EE  R + E +  V R +  L +LE    +  ++
Sbjct: 2527 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE---QQRRQQ 2583

Query: 1558 LDFLREENHKLQLERQNLQLETRRLQSE------INMAATET----RDLRNMTVADSGTN 1607
             + L EEN +L+ + Q L+ + R   +         +AAT+T    RD  +   A++   
Sbjct: 2584 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2643

Query: 1608 HDSRLWSLERELDDLKRLSKDKDLEIDELQK-RLGSVAV----KREQRENHL--RRSIV- 1659
            H      L R++   +RL +   L  +ELQ+   G   V    +RE   ++L  R SI  
Sbjct: 2644 HS--FDGLRRKV-SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG 2700

Query: 1660 VIHPDTGRELSPEEA-HRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKK 1718
            ++   T  +LS   A  R  L      + L +Q               S  + D    ++
Sbjct: 2701 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQ-------------AASGFLLDPVRNRR 2747

Query: 1719 FSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK 1756
             ++ EA++ G + P  + + ++ + ++       +GQ+
Sbjct: 2748 LTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQ 2785



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 40/110 (36%), Positives = 71/110 (64%), Gaps = 1/110 (0%)

Query: 1646 KREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNG 1705
            K   + +  +R +V++ P+TG+E+S  EA+R GLID   +++L  QEC+WEEI++   +G
Sbjct: 4129 KTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDG 4188

Query: 1706 -ESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSG 1754
               S+I DR+SG+++ I++A+    +  +  D+Y    +SI E A ++SG
Sbjct: 4189 VVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4238


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  413 bits (1062), Expect = e-115
 Identities = 426/1763 (24%), Positives = 785/1763 (44%), Gaps = 218/1763 (12%)

Query: 27   LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86
            L  ++ +LQ  A   E+ +   +A +QSD+  L  G+ P+      + +  ++ ++ +L 
Sbjct: 362  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 421

Query: 87   ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK------------QIYRLAVKEVD- 133
             D    K  +HPQG+ +   + +L ER+  +R ++             Q+ ++ ++ V  
Sbjct: 422  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 481

Query: 134  -PQVNWAAL---------VEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLA 183
             P++  + L         VEE   +++   +G DLP V+ Q+  H   H  ++     + 
Sbjct: 482  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 541

Query: 184  KDGDKEQN-------------SELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD 230
            +    E                 L  +Y KLL +S+AR + L SL  ++   T EL WL+
Sbjct: 542  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 601

Query: 231  QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290
            ++ +  + +DWSDRN +  +++  Y   + R LE KE++I +L + GD+LL  +HP R +
Sbjct: 602  EKEEEEVGFDWSDRNTNMTAKKESYSALM-RELELKEKKIKELQNAGDRLLREDHPARPT 660

Query: 291  IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD 350
            +E+   A+   W   L L  C E+HLK    Y QF  DV++A+  L+K+   L +KY  D
Sbjct: 661  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 720

Query: 351  FKDRY-QIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-PLKP-IPVEAL 407
                  ++E LL++  D+++ L++Y+  + GL KR + VV LK R    P++  +P+ A+
Sbjct: 721  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 780

Query: 408  CDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPP------------ 454
            CD++  +  + +G    L      S W+++ S+G++   P+VCF++PP            
Sbjct: 781  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 840

Query: 455  ---------------TDPEALALADSLGSQYRSVRQKAAGSKRTL---QQRYEVLKTENP 496
                            D ++L    SL    + +R  +  + RTL   +QR  +   E  
Sbjct: 841  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 900

Query: 497  -----GDASDLQG--------------------RQLLAGLDKVASDLDRQEKAITGI--- 528
                  D+ D  G                    +QLL  L++ A +  R ++ I+ +   
Sbjct: 901  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 960

Query: 529  --------------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI 574
                          LR PL++  A ++ A+R  + +    E+  +     R +AE E  +
Sbjct: 961  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1019

Query: 575  QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH 634
                 S   P LR+ +E T  K E +  L  +  EK+   + + +  Q + E+L  HE  
Sbjct: 1020 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1079

Query: 635  LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC 694
            L +   VP +   L++    L  +  + +AQ+     +   L+ A++    L  R  E  
Sbjct: 1080 LKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1139

Query: 695  PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEP 754
             ++ER    V +L +R+  +  Q + R + L+       ++    D +  +L      + 
Sbjct: 1140 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1199

Query: 755  Q-----ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLR 809
            Q       DS +  E +L+ ++ LL+EI    ++V++    ++QY  A+KDYEL+    +
Sbjct: 1200 QIQAMPLADSQAVRE-QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1258

Query: 810  SLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQ 869
            + L+      +  +K+ ++QS +  V +E   L   ++E+  +  Q ++ +   L  + +
Sbjct: 1259 AQLE----PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1314

Query: 870  QPEVEVTHETLQRNRPDSGVEEAWKIRKELDE-ETERRRQLENEVKSTQEEIWTLRNQGP 928
            +  +       +R R  + VE A + +++L E   + + Q E E K  Q+ +        
Sbjct: 1315 EERLAEQQRAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-------- 1365

Query: 929  QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988
            QE VVR+E                      + Q + + +QEEL+ L+ Q    E + +  
Sbjct: 1366 QEEVVRRE------------------EAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKAR 1406

Query: 989  GQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRA 1048
              E   +  LRIE      +E+  +R +LEA  RQ+G  E E+  L+ R      E++ A
Sbjct: 1407 QAEAAERSRLRIE------EEIRVVRLQLEATERQRGGAEGELQALRARA-----EEAEA 1455

Query: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDK---LKRLEKER 1105
            Q++  ++E  +L+   Q E+     Q   Q + +L  + + E    ++K   L+ LE+ R
Sbjct: 1456 QKRQAQEEAERLRRQVQDES-----QRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1510

Query: 1106 AMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEEN 1165
              AE         +VE+    +  +    R  E E    RAS  EKT  L +  +L+EE+
Sbjct: 1511 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--SLQEEH 1568

Query: 1166 AKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSEL-EALRRRGP 1224
              V    ++RE          E      +  E ER    AE +L  +Q +  EALR R  
Sbjct: 1569 VAVA---QLRE----------EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615

Query: 1225 QVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
              EV +  K + + + + + E+  +  R     + + + + +L   +L+K+ Q  + T  
Sbjct: 1616 AEEVAQ-QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1674

Query: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
            Q    E  QE+++ + + +  E+    + +L EE+  ++  E   A+Q+ Q    E    
Sbjct: 1675 QRLAAE--QELIRLRAETEQGEQ----QRQLLEEELARLQREAAAATQKRQELEAELAKV 1728

Query: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
            R +  V+     R EEE    +E S   + ++ E  +  +L  E  RL+    E +RQ  
Sbjct: 1729 RAEMEVLLASKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQ-R 1785

Query: 1405 ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRL 1464
            +L  E  AR+ AE E + L ++LAA+     EA    T  +  + +++ +  R   L RL
Sbjct: 1786 QLAEEDAARQRAEAE-RVLAEKLAAI----GEATRLKTEAEIALKEKEAENER---LRRL 1837

Query: 1465 QLEEEQHRRQLLEGELE---TLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518
              +E   RR+L E   +    +  +LA L KA   E++ +  L E    ++   E+EI  
Sbjct: 1838 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1897

Query: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578
            LK+S E+ +  K EL++E+ R+ +   +     SK   EL+  R+     + ER+  + E
Sbjct: 1898 LKASFEKAAAGKAELELELGRIRSNAEDT--LRSKEQAELEAARQRQLAAEEERRRREAE 1955

Query: 1579 TR---RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDE 1635
             R    L +E   A      L  +    +      RL     E +  ++L   ++     
Sbjct: 1956 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE-RAEQESARQLQLAQEAAQKR 2014

Query: 1636 LQKRLGSVAVKREQRENHLRRSI 1658
            LQ    + A   +Q+E  L++++
Sbjct: 2015 LQAEEKAHAFAVQQKEQELQQTL 2037



 Score =  187 bits (476), Expect = 6e-47
 Identities = 333/1478 (22%), Positives = 606/1478 (41%), Gaps = 254/1478 (17%)

Query: 475  QKAAGSKRTLQQRYEVLKTENPGDASDLQGR--QLLAGLDKVASDLDRQEKAITGILRPP 532
            + A   +R L + +   K +   +A +LQ R  + +   ++ A D  +Q+++I   L+  
Sbjct: 1334 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1393

Query: 533  LEQGRAVQDSAERAKDLKNITNELLRIEPE------------KTRSTAEGE--------- 571
             +   A  +   +A+  +      LRIE E            + R  AEGE         
Sbjct: 1394 RQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1451

Query: 572  -AFIQALPGSGTTPLLRTRVED-TNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWEL-- 627
             A  Q          LR +V+D + RK +  ++L    + + + A   +++LQ   EL  
Sbjct: 1452 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1511

Query: 628  -LATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTL 686
                 E  L Q + V  + +V  +      +   ELQ++++   E    L+ + Q     
Sbjct: 1512 QAEEAERRLRQAE-VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1570

Query: 687  ASRFQEHCPDLERQEAEVHKLGQRFNN--------------LRQQVERRAQSLQSAKAAY 732
             ++ +E      +Q+AE  +  +                  LR Q E  AQ    A+A  
Sbjct: 1571 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1630

Query: 733  EHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR----EQEVQKIC 788
            E   +  +   +        E Q        E +L+ Q+ L +  A +    EQE+ ++ 
Sbjct: 1631 E---KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1687

Query: 789  ANSQQYQQ-------------------AVKDYELEAEKLRSLLDLENGRSSHVSKRARLQ 829
            A ++Q +Q                     K  ELEAE  +   ++E   +S        +
Sbjct: 1688 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747

Query: 830  SPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNR----P 885
            S + K K+   A A +F E+ A    RL+ L       RQ  E +   +  +  R     
Sbjct: 1748 STSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1806

Query: 886  DSGVEEAWKIR-------KELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVL 938
             + + EA +++       KE + E ER R+L  +    +  +     Q   +   R   L
Sbjct: 1807 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1866

Query: 939  KKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVL 998
            +K  D  LE     ++ TL + +     ++EE+ AL+        E    G+  +  E+ 
Sbjct: 1867 RKASDSELERQKGLVEDTLRQRRQ----VEEEILALKASF-----EKAAAGKAELELELG 1917

Query: 999  RIEPDRAQADEVLQLRE--ELEALRRQKGARE-----------------AEVLLLQQRVA 1039
            RI   R+ A++ L+ +E  ELEA R+++ A E                 AE    +QR A
Sbjct: 1918 RI---RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1974

Query: 1040 ALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK--------QEEEL 1091
            AL EE  R + KV E   ++ + + +   + Q  QE  Q++ Q  EK        +E+EL
Sbjct: 1975 AL-EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2033

Query: 1092 S-FLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE 1150
               LQ +   L++ R  AE      E  + E     ERE +   RQ E EA + + S  E
Sbjct: 2034 QQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVE-EAERLKQSAEE 2091

Query: 1151 KTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLR 1210
            + +   +  A  E+  K   QE  R       +A++E A LR +        + A+ ++ 
Sbjct: 2092 QAQARAQAQAAAEKLRKEAEQEAAR-------RAQAEQAALRQK--------QAADAEME 2136

Query: 1211 SYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE---MEKELQRLREEIVDKTRLIERCDL 1267
             ++   E   R+  QVE +  T  +   +TD +   +++ELQRL+ E  +  R   + + 
Sbjct: 2137 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2196

Query: 1268 EIYQLKKEIQALKDTKPQVQT---------KEVVQEILQFQEDP--QTKEEVASLRAKLS 1316
            E++ ++ +++ L   K +++          K+  Q  LQ + +   Q  EE A L     
Sbjct: 2197 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2256

Query: 1317 E----EQKKQVDLERERASQEEQIARK------------EEELSRVKERVVQQEVVRYEE 1360
            E     Q  + DL ++RA  E+ +  K            E EL + ++ + Q++  R +E
Sbjct: 2257 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2316

Query: 1361 EPG-----LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQA--- 1412
            +       L  E   F  +++ E ++  ++ AE  RL+ R  E+ R     E + Q    
Sbjct: 2317 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2376

Query: 1413 -----------------------------RREAEREVQRLQQRLAALEQEEAEAREKVTH 1443
                                         R++++ + +RL++ +A LE+E+ + +++   
Sbjct: 2377 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2436

Query: 1444 TQKVVLQQDPQQAREHALLR----LQLEEEQHRRQLLEGE--LETLRRKLAALEKAEVKE 1497
             Q  +  ++ Q  ++  LL+    LQ      +  LL+ E  +E  + KL  L + EV +
Sbjct: 2437 LQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2494

Query: 1498 KVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKE 1557
               L E  Q ++   EQE QRL +S+EE  R + E +  V R +  L +LE    +  ++
Sbjct: 2495 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE---QQRRQQ 2551

Query: 1558 LDFLREENHKLQLERQNLQLETRRLQSE------INMAATET----RDLRNMTVADSGTN 1607
             + L EEN +L+ + Q L+ + R   +         +AAT+T    RD  +   A++   
Sbjct: 2552 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2611

Query: 1608 HDSRLWSLERELDDLKRLSKDKDLEIDELQK-RLGSVAV----KREQRENHL--RRSIV- 1659
            H      L R++   +RL +   L  +ELQ+   G   V    +RE   ++L  R SI  
Sbjct: 2612 HS--FDGLRRKV-SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG 2668

Query: 1660 VIHPDTGRELSPEEA-HRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKK 1718
            ++   T  +LS   A  R  L      + L +Q               S  + D    ++
Sbjct: 2669 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQ-------------AASGFLLDPVRNRR 2715

Query: 1719 FSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK 1756
             ++ EA++ G + P  + + ++ + ++       +GQ+
Sbjct: 2716 LTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQ 2753



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 40/110 (36%), Positives = 71/110 (64%), Gaps = 1/110 (0%)

Query: 1646 KREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNG 1705
            K   + +  +R +V++ P+TG+E+S  EA+R GLID   +++L  QEC+WEEI++   +G
Sbjct: 4097 KTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDG 4156

Query: 1706 -ESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSG 1754
               S+I DR+SG+++ I++A+    +  +  D+Y    +SI E A ++SG
Sbjct: 4157 VVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4206


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  413 bits (1062), Expect = e-115
 Identities = 426/1763 (24%), Positives = 785/1763 (44%), Gaps = 218/1763 (12%)

Query: 27   LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86
            L  ++ +LQ  A   E+ +   +A +QSD+  L  G+ P+      + +  ++ ++ +L 
Sbjct: 531  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 590

Query: 87   ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK------------QIYRLAVKEVD- 133
             D    K  +HPQG+ +   + +L ER+  +R ++             Q+ ++ ++ V  
Sbjct: 591  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 650

Query: 134  -PQVNWAAL---------VEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLA 183
             P++  + L         VEE   +++   +G DLP V+ Q+  H   H  ++     + 
Sbjct: 651  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 710

Query: 184  KDGDKEQN-------------SELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD 230
            +    E                 L  +Y KLL +S+AR + L SL  ++   T EL WL+
Sbjct: 711  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 770

Query: 231  QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290
            ++ +  + +DWSDRN +  +++  Y   + R LE KE++I +L + GD+LL  +HP R +
Sbjct: 771  EKEEEEVGFDWSDRNTNMTAKKESYSALM-RELELKEKKIKELQNAGDRLLREDHPARPT 829

Query: 291  IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD 350
            +E+   A+   W   L L  C E+HLK    Y QF  DV++A+  L+K+   L +KY  D
Sbjct: 830  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 889

Query: 351  FKDRY-QIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-PLKP-IPVEAL 407
                  ++E LL++  D+++ L++Y+  + GL KR + VV LK R    P++  +P+ A+
Sbjct: 890  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 949

Query: 408  CDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPP------------ 454
            CD++  +  + +G    L      S W+++ S+G++   P+VCF++PP            
Sbjct: 950  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 1009

Query: 455  ---------------TDPEALALADSLGSQYRSVRQKAAGSKRTL---QQRYEVLKTENP 496
                            D ++L    SL    + +R  +  + RTL   +QR  +   E  
Sbjct: 1010 EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 1069

Query: 497  -----GDASDLQG--------------------RQLLAGLDKVASDLDRQEKAITGI--- 528
                  D+ D  G                    +QLL  L++ A +  R ++ I+ +   
Sbjct: 1070 YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 1129

Query: 529  --------------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI 574
                          LR PL++  A ++ A+R  + +    E+  +     R +AE E  +
Sbjct: 1130 RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1188

Query: 575  QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH 634
                 S   P LR+ +E T  K E +  L  +  EK+   + + +  Q + E+L  HE  
Sbjct: 1189 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1248

Query: 635  LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC 694
            L +   VP +   L++    L  +  + +AQ+     +   L+ A++    L  R  E  
Sbjct: 1249 LKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1308

Query: 695  PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEP 754
             ++ER    V +L +R+  +  Q + R + L+       ++    D +  +L      + 
Sbjct: 1309 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1368

Query: 755  Q-----ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLR 809
            Q       DS +  E +L+ ++ LL+EI    ++V++    ++QY  A+KDYEL+    +
Sbjct: 1369 QIQAMPLADSQAVRE-QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1427

Query: 810  SLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQ 869
            + L+      +  +K+ ++QS +  V +E   L   ++E+  +  Q ++ +   L  + +
Sbjct: 1428 AQLE----PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1483

Query: 870  QPEVEVTHETLQRNRPDSGVEEAWKIRKELDE-ETERRRQLENEVKSTQEEIWTLRNQGP 928
            +  +       +R R  + VE A + +++L E   + + Q E E K  Q+ +        
Sbjct: 1484 EERLAEQQRAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-------- 1534

Query: 929  QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988
            QE VVR+E                      + Q + + +QEEL+ L+ Q    E + +  
Sbjct: 1535 QEEVVRRE------------------EAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKAR 1575

Query: 989  GQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRA 1048
              E   +  LRIE      +E+  +R +LEA  RQ+G  E E+  L+ R      E++ A
Sbjct: 1576 QAEAAERSRLRIE------EEIRVVRLQLEATERQRGGAEGELQALRARA-----EEAEA 1624

Query: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDK---LKRLEKER 1105
            Q++  ++E  +L+   Q E+     Q   Q + +L  + + E    ++K   L+ LE+ R
Sbjct: 1625 QKRQAQEEAERLRRQVQDES-----QRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1679

Query: 1106 AMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEEN 1165
              AE         +VE+    +  +    R  E E    RAS  EKT  L +  +L+EE+
Sbjct: 1680 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--SLQEEH 1737

Query: 1166 AKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSEL-EALRRRGP 1224
              V    ++RE          E      +  E ER    AE +L  +Q +  EALR R  
Sbjct: 1738 VAVA---QLRE----------EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784

Query: 1225 QVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
              EV +  K + + + + + E+  +  R     + + + + +L   +L+K+ Q  + T  
Sbjct: 1785 AEEVAQ-QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1843

Query: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
            Q    E  QE+++ + + +  E+    + +L EE+  ++  E   A+Q+ Q    E    
Sbjct: 1844 QRLAAE--QELIRLRAETEQGEQ----QRQLLEEELARLQREAAAATQKRQELEAELAKV 1897

Query: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
            R +  V+     R EEE    +E S   + ++ E  +  +L  E  RL+    E +RQ  
Sbjct: 1898 RAEMEVLLASKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQ-R 1954

Query: 1405 ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRL 1464
            +L  E  AR+ AE E + L ++LAA+     EA    T  +  + +++ +  R   L RL
Sbjct: 1955 QLAEEDAARQRAEAE-RVLAEKLAAI----GEATRLKTEAEIALKEKEAENER---LRRL 2006

Query: 1465 QLEEEQHRRQLLEGELE---TLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518
              +E   RR+L E   +    +  +LA L KA   E++ +  L E    ++   E+EI  
Sbjct: 2007 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 2066

Query: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578
            LK+S E+ +  K EL++E+ R+ +   +     SK   EL+  R+     + ER+  + E
Sbjct: 2067 LKASFEKAAAGKAELELELGRIRSNAEDT--LRSKEQAELEAARQRQLAAEEERRRREAE 2124

Query: 1579 TR---RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDE 1635
             R    L +E   A      L  +    +      RL     E +  ++L   ++     
Sbjct: 2125 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE-RAEQESARQLQLAQEAAQKR 2183

Query: 1636 LQKRLGSVAVKREQRENHLRRSI 1658
            LQ    + A   +Q+E  L++++
Sbjct: 2184 LQAEEKAHAFAVQQKEQELQQTL 2206



 Score =  187 bits (476), Expect = 6e-47
 Identities = 333/1478 (22%), Positives = 606/1478 (41%), Gaps = 254/1478 (17%)

Query: 475  QKAAGSKRTLQQRYEVLKTENPGDASDLQGR--QLLAGLDKVASDLDRQEKAITGILRPP 532
            + A   +R L + +   K +   +A +LQ R  + +   ++ A D  +Q+++I   L+  
Sbjct: 1503 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562

Query: 533  LEQGRAVQDSAERAKDLKNITNELLRIEPE------------KTRSTAEGE--------- 571
             +   A  +   +A+  +      LRIE E            + R  AEGE         
Sbjct: 1563 RQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1620

Query: 572  -AFIQALPGSGTTPLLRTRVED-TNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWEL-- 627
             A  Q          LR +V+D + RK +  ++L    + + + A   +++LQ   EL  
Sbjct: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680

Query: 628  -LATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTL 686
                 E  L Q + V  + +V  +      +   ELQ++++   E    L+ + Q     
Sbjct: 1681 QAEEAERRLRQAE-VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1739

Query: 687  ASRFQEHCPDLERQEAEVHKLGQRFNN--------------LRQQVERRAQSLQSAKAAY 732
             ++ +E      +Q+AE  +  +                  LR Q E  AQ    A+A  
Sbjct: 1740 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1799

Query: 733  EHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR----EQEVQKIC 788
            E   +  +   +        E Q        E +L+ Q+ L +  A +    EQE+ ++ 
Sbjct: 1800 E---KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1856

Query: 789  ANSQQYQQ-------------------AVKDYELEAEKLRSLLDLENGRSSHVSKRARLQ 829
            A ++Q +Q                     K  ELEAE  +   ++E   +S        +
Sbjct: 1857 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916

Query: 830  SPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNR----P 885
            S + K K+   A A +F E+ A    RL+ L       RQ  E +   +  +  R     
Sbjct: 1917 STSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1975

Query: 886  DSGVEEAWKIR-------KELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVL 938
             + + EA +++       KE + E ER R+L  +    +  +     Q   +   R   L
Sbjct: 1976 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 2035

Query: 939  KKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVL 998
            +K  D  LE     ++ TL + +     ++EE+ AL+        E    G+  +  E+ 
Sbjct: 2036 RKASDSELERQKGLVEDTLRQRRQ----VEEEILALKASF-----EKAAAGKAELELELG 2086

Query: 999  RIEPDRAQADEVLQLRE--ELEALRRQKGARE-----------------AEVLLLQQRVA 1039
            RI   R+ A++ L+ +E  ELEA R+++ A E                 AE    +QR A
Sbjct: 2087 RI---RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143

Query: 1040 ALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK--------QEEEL 1091
            AL EE  R + KV E   ++ + + +   + Q  QE  Q++ Q  EK        +E+EL
Sbjct: 2144 AL-EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2202

Query: 1092 S-FLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE 1150
               LQ +   L++ R  AE      E  + E     ERE +   RQ E EA + + S  E
Sbjct: 2203 QQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVE-EAERLKQSAEE 2260

Query: 1151 KTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLR 1210
            + +   +  A  E+  K   QE  R       +A++E A LR +        + A+ ++ 
Sbjct: 2261 QAQARAQAQAAAEKLRKEAEQEAAR-------RAQAEQAALRQK--------QAADAEME 2305

Query: 1211 SYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE---MEKELQRLREEIVDKTRLIERCDL 1267
             ++   E   R+  QVE +  T  +   +TD +   +++ELQRL+ E  +  R   + + 
Sbjct: 2306 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2365

Query: 1268 EIYQLKKEIQALKDTKPQVQT---------KEVVQEILQFQEDP--QTKEEVASLRAKLS 1316
            E++ ++ +++ L   K +++          K+  Q  LQ + +   Q  EE A L     
Sbjct: 2366 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2425

Query: 1317 E----EQKKQVDLERERASQEEQIARK------------EEELSRVKERVVQQEVVRYEE 1360
            E     Q  + DL ++RA  E+ +  K            E EL + ++ + Q++  R +E
Sbjct: 2426 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2485

Query: 1361 EPG-----LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQA--- 1412
            +       L  E   F  +++ E ++  ++ AE  RL+ R  E+ R     E + Q    
Sbjct: 2486 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2545

Query: 1413 -----------------------------RREAEREVQRLQQRLAALEQEEAEAREKVTH 1443
                                         R++++ + +RL++ +A LE+E+ + +++   
Sbjct: 2546 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2605

Query: 1444 TQKVVLQQDPQQAREHALLR----LQLEEEQHRRQLLEGE--LETLRRKLAALEKAEVKE 1497
             Q  +  ++ Q  ++  LL+    LQ      +  LL+ E  +E  + KL  L + EV +
Sbjct: 2606 LQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2663

Query: 1498 KVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKE 1557
               L E  Q ++   EQE QRL +S+EE  R + E +  V R +  L +LE    +  ++
Sbjct: 2664 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE---QQRRQQ 2720

Query: 1558 LDFLREENHKLQLERQNLQLETRRLQSE------INMAATET----RDLRNMTVADSGTN 1607
             + L EEN +L+ + Q L+ + R   +         +AAT+T    RD  +   A++   
Sbjct: 2721 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2780

Query: 1608 HDSRLWSLERELDDLKRLSKDKDLEIDELQK-RLGSVAV----KREQRENHL--RRSIV- 1659
            H      L R++   +RL +   L  +ELQ+   G   V    +RE   ++L  R SI  
Sbjct: 2781 HS--FDGLRRKV-SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG 2837

Query: 1660 VIHPDTGRELSPEEA-HRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKK 1718
            ++   T  +LS   A  R  L      + L +Q               S  + D    ++
Sbjct: 2838 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQ-------------AASGFLLDPVRNRR 2884

Query: 1719 FSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK 1756
             ++ EA++ G + P  + + ++ + ++       +GQ+
Sbjct: 2885 LTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQ 2922



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 40/110 (36%), Positives = 71/110 (64%), Gaps = 1/110 (0%)

Query: 1646 KREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNG 1705
            K   + +  +R +V++ P+TG+E+S  EA+R GLID   +++L  QEC+WEEI++   +G
Sbjct: 4266 KTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDG 4325

Query: 1706 -ESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSG 1754
               S+I DR+SG+++ I++A+    +  +  D+Y    +SI E A ++SG
Sbjct: 4326 VVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4375


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  413 bits (1062), Expect = e-115
 Identities = 426/1763 (24%), Positives = 785/1763 (44%), Gaps = 218/1763 (12%)

Query: 27   LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86
            L  ++ +LQ  A   E+ +   +A +QSD+  L  G+ P+      + +  ++ ++ +L 
Sbjct: 372  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 431

Query: 87   ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK------------QIYRLAVKEVD- 133
             D    K  +HPQG+ +   + +L ER+  +R ++             Q+ ++ ++ V  
Sbjct: 432  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 491

Query: 134  -PQVNWAAL---------VEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLA 183
             P++  + L         VEE   +++   +G DLP V+ Q+  H   H  ++     + 
Sbjct: 492  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 551

Query: 184  KDGDKEQN-------------SELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD 230
            +    E                 L  +Y KLL +S+AR + L SL  ++   T EL WL+
Sbjct: 552  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 611

Query: 231  QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290
            ++ +  + +DWSDRN +  +++  Y   + R LE KE++I +L + GD+LL  +HP R +
Sbjct: 612  EKEEEEVGFDWSDRNTNMTAKKESYSALM-RELELKEKKIKELQNAGDRLLREDHPARPT 670

Query: 291  IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD 350
            +E+   A+   W   L L  C E+HLK    Y QF  DV++A+  L+K+   L +KY  D
Sbjct: 671  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 730

Query: 351  FKDRY-QIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-PLKP-IPVEAL 407
                  ++E LL++  D+++ L++Y+  + GL KR + VV LK R    P++  +P+ A+
Sbjct: 731  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 790

Query: 408  CDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPP------------ 454
            CD++  +  + +G    L      S W+++ S+G++   P+VCF++PP            
Sbjct: 791  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 850

Query: 455  ---------------TDPEALALADSLGSQYRSVRQKAAGSKRTL---QQRYEVLKTENP 496
                            D ++L    SL    + +R  +  + RTL   +QR  +   E  
Sbjct: 851  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 910

Query: 497  -----GDASDLQG--------------------RQLLAGLDKVASDLDRQEKAITGI--- 528
                  D+ D  G                    +QLL  L++ A +  R ++ I+ +   
Sbjct: 911  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 970

Query: 529  --------------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI 574
                          LR PL++  A ++ A+R  + +    E+  +     R +AE E  +
Sbjct: 971  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1029

Query: 575  QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH 634
                 S   P LR+ +E T  K E +  L  +  EK+   + + +  Q + E+L  HE  
Sbjct: 1030 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1089

Query: 635  LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC 694
            L +   VP +   L++    L  +  + +AQ+     +   L+ A++    L  R  E  
Sbjct: 1090 LKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1149

Query: 695  PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEP 754
             ++ER    V +L +R+  +  Q + R + L+       ++    D +  +L      + 
Sbjct: 1150 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1209

Query: 755  Q-----ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLR 809
            Q       DS +  E +L+ ++ LL+EI    ++V++    ++QY  A+KDYEL+    +
Sbjct: 1210 QIQAMPLADSQAVRE-QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1268

Query: 810  SLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQ 869
            + L+      +  +K+ ++QS +  V +E   L   ++E+  +  Q ++ +   L  + +
Sbjct: 1269 AQLE----PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1324

Query: 870  QPEVEVTHETLQRNRPDSGVEEAWKIRKELDE-ETERRRQLENEVKSTQEEIWTLRNQGP 928
            +  +       +R R  + VE A + +++L E   + + Q E E K  Q+ +        
Sbjct: 1325 EERLAEQQRAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-------- 1375

Query: 929  QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988
            QE VVR+E                      + Q + + +QEEL+ L+ Q    E + +  
Sbjct: 1376 QEEVVRRE------------------EAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKAR 1416

Query: 989  GQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRA 1048
              E   +  LRIE      +E+  +R +LEA  RQ+G  E E+  L+ R      E++ A
Sbjct: 1417 QAEAAERSRLRIE------EEIRVVRLQLEATERQRGGAEGELQALRARA-----EEAEA 1465

Query: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDK---LKRLEKER 1105
            Q++  ++E  +L+   Q E+     Q   Q + +L  + + E    ++K   L+ LE+ R
Sbjct: 1466 QKRQAQEEAERLRRQVQDES-----QRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1520

Query: 1106 AMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEEN 1165
              AE         +VE+    +  +    R  E E    RAS  EKT  L +  +L+EE+
Sbjct: 1521 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--SLQEEH 1578

Query: 1166 AKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSEL-EALRRRGP 1224
              V    ++RE          E      +  E ER    AE +L  +Q +  EALR R  
Sbjct: 1579 VAVA---QLRE----------EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625

Query: 1225 QVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
              EV +  K + + + + + E+  +  R     + + + + +L   +L+K+ Q  + T  
Sbjct: 1626 AEEVAQ-QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1684

Query: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
            Q    E  QE+++ + + +  E+    + +L EE+  ++  E   A+Q+ Q    E    
Sbjct: 1685 QRLAAE--QELIRLRAETEQGEQ----QRQLLEEELARLQREAAAATQKRQELEAELAKV 1738

Query: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
            R +  V+     R EEE    +E S   + ++ E  +  +L  E  RL+    E +RQ  
Sbjct: 1739 RAEMEVLLASKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQ-R 1795

Query: 1405 ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRL 1464
            +L  E  AR+ AE E + L ++LAA+     EA    T  +  + +++ +  R   L RL
Sbjct: 1796 QLAEEDAARQRAEAE-RVLAEKLAAI----GEATRLKTEAEIALKEKEAENER---LRRL 1847

Query: 1465 QLEEEQHRRQLLEGELE---TLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518
              +E   RR+L E   +    +  +LA L KA   E++ +  L E    ++   E+EI  
Sbjct: 1848 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1907

Query: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578
            LK+S E+ +  K EL++E+ R+ +   +     SK   EL+  R+     + ER+  + E
Sbjct: 1908 LKASFEKAAAGKAELELELGRIRSNAEDT--LRSKEQAELEAARQRQLAAEEERRRREAE 1965

Query: 1579 TR---RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDE 1635
             R    L +E   A      L  +    +      RL     E +  ++L   ++     
Sbjct: 1966 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE-RAEQESARQLQLAQEAAQKR 2024

Query: 1636 LQKRLGSVAVKREQRENHLRRSI 1658
            LQ    + A   +Q+E  L++++
Sbjct: 2025 LQAEEKAHAFAVQQKEQELQQTL 2047



 Score =  187 bits (476), Expect = 6e-47
 Identities = 333/1478 (22%), Positives = 606/1478 (41%), Gaps = 254/1478 (17%)

Query: 475  QKAAGSKRTLQQRYEVLKTENPGDASDLQGR--QLLAGLDKVASDLDRQEKAITGILRPP 532
            + A   +R L + +   K +   +A +LQ R  + +   ++ A D  +Q+++I   L+  
Sbjct: 1344 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403

Query: 533  LEQGRAVQDSAERAKDLKNITNELLRIEPE------------KTRSTAEGE--------- 571
             +   A  +   +A+  +      LRIE E            + R  AEGE         
Sbjct: 1404 RQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1461

Query: 572  -AFIQALPGSGTTPLLRTRVED-TNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWEL-- 627
             A  Q          LR +V+D + RK +  ++L    + + + A   +++LQ   EL  
Sbjct: 1462 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1521

Query: 628  -LATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTL 686
                 E  L Q + V  + +V  +      +   ELQ++++   E    L+ + Q     
Sbjct: 1522 QAEEAERRLRQAE-VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1580

Query: 687  ASRFQEHCPDLERQEAEVHKLGQRFNN--------------LRQQVERRAQSLQSAKAAY 732
             ++ +E      +Q+AE  +  +                  LR Q E  AQ    A+A  
Sbjct: 1581 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1640

Query: 733  EHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR----EQEVQKIC 788
            E   +  +   +        E Q        E +L+ Q+ L +  A +    EQE+ ++ 
Sbjct: 1641 E---KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1697

Query: 789  ANSQQYQQ-------------------AVKDYELEAEKLRSLLDLENGRSSHVSKRARLQ 829
            A ++Q +Q                     K  ELEAE  +   ++E   +S        +
Sbjct: 1698 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757

Query: 830  SPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNR----P 885
            S + K K+   A A +F E+ A    RL+ L       RQ  E +   +  +  R     
Sbjct: 1758 STSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1816

Query: 886  DSGVEEAWKIR-------KELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVL 938
             + + EA +++       KE + E ER R+L  +    +  +     Q   +   R   L
Sbjct: 1817 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1876

Query: 939  KKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVL 998
            +K  D  LE     ++ TL + +     ++EE+ AL+        E    G+  +  E+ 
Sbjct: 1877 RKASDSELERQKGLVEDTLRQRRQ----VEEEILALKASF-----EKAAAGKAELELELG 1927

Query: 999  RIEPDRAQADEVLQLRE--ELEALRRQKGARE-----------------AEVLLLQQRVA 1039
            RI   R+ A++ L+ +E  ELEA R+++ A E                 AE    +QR A
Sbjct: 1928 RI---RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1984

Query: 1040 ALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK--------QEEEL 1091
            AL EE  R + KV E   ++ + + +   + Q  QE  Q++ Q  EK        +E+EL
Sbjct: 1985 AL-EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2043

Query: 1092 S-FLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE 1150
               LQ +   L++ R  AE      E  + E     ERE +   RQ E EA + + S  E
Sbjct: 2044 QQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVE-EAERLKQSAEE 2101

Query: 1151 KTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLR 1210
            + +   +  A  E+  K   QE  R       +A++E A LR +        + A+ ++ 
Sbjct: 2102 QAQARAQAQAAAEKLRKEAEQEAAR-------RAQAEQAALRQK--------QAADAEME 2146

Query: 1211 SYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE---MEKELQRLREEIVDKTRLIERCDL 1267
             ++   E   R+  QVE +  T  +   +TD +   +++ELQRL+ E  +  R   + + 
Sbjct: 2147 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2206

Query: 1268 EIYQLKKEIQALKDTKPQVQT---------KEVVQEILQFQEDP--QTKEEVASLRAKLS 1316
            E++ ++ +++ L   K +++          K+  Q  LQ + +   Q  EE A L     
Sbjct: 2207 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2266

Query: 1317 E----EQKKQVDLERERASQEEQIARK------------EEELSRVKERVVQQEVVRYEE 1360
            E     Q  + DL ++RA  E+ +  K            E EL + ++ + Q++  R +E
Sbjct: 2267 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2326

Query: 1361 EPG-----LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQA--- 1412
            +       L  E   F  +++ E ++  ++ AE  RL+ R  E+ R     E + Q    
Sbjct: 2327 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2386

Query: 1413 -----------------------------RREAEREVQRLQQRLAALEQEEAEAREKVTH 1443
                                         R++++ + +RL++ +A LE+E+ + +++   
Sbjct: 2387 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2446

Query: 1444 TQKVVLQQDPQQAREHALLR----LQLEEEQHRRQLLEGE--LETLRRKLAALEKAEVKE 1497
             Q  +  ++ Q  ++  LL+    LQ      +  LL+ E  +E  + KL  L + EV +
Sbjct: 2447 LQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2504

Query: 1498 KVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKE 1557
               L E  Q ++   EQE QRL +S+EE  R + E +  V R +  L +LE    +  ++
Sbjct: 2505 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE---QQRRQQ 2561

Query: 1558 LDFLREENHKLQLERQNLQLETRRLQSE------INMAATET----RDLRNMTVADSGTN 1607
             + L EEN +L+ + Q L+ + R   +         +AAT+T    RD  +   A++   
Sbjct: 2562 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2621

Query: 1608 HDSRLWSLERELDDLKRLSKDKDLEIDELQK-RLGSVAV----KREQRENHL--RRSIV- 1659
            H      L R++   +RL +   L  +ELQ+   G   V    +RE   ++L  R SI  
Sbjct: 2622 HS--FDGLRRKV-SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG 2678

Query: 1660 VIHPDTGRELSPEEA-HRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKK 1718
            ++   T  +LS   A  R  L      + L +Q               S  + D    ++
Sbjct: 2679 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQ-------------AASGFLLDPVRNRR 2725

Query: 1719 FSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK 1756
             ++ EA++ G + P  + + ++ + ++       +GQ+
Sbjct: 2726 LTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQ 2763



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 40/110 (36%), Positives = 71/110 (64%), Gaps = 1/110 (0%)

Query: 1646 KREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNG 1705
            K   + +  +R +V++ P+TG+E+S  EA+R GLID   +++L  QEC+WEEI++   +G
Sbjct: 4107 KTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDG 4166

Query: 1706 -ESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSG 1754
               S+I DR+SG+++ I++A+    +  +  D+Y    +SI E A ++SG
Sbjct: 4167 VVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4216


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  413 bits (1062), Expect = e-115
 Identities = 426/1763 (24%), Positives = 785/1763 (44%), Gaps = 218/1763 (12%)

Query: 27   LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86
            L  ++ +LQ  A   E+ +   +A +QSD+  L  G+ P+      + +  ++ ++ +L 
Sbjct: 380  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 439

Query: 87   ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK------------QIYRLAVKEVD- 133
             D    K  +HPQG+ +   + +L ER+  +R ++             Q+ ++ ++ V  
Sbjct: 440  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 499

Query: 134  -PQVNWAAL---------VEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLA 183
             P++  + L         VEE   +++   +G DLP V+ Q+  H   H  ++     + 
Sbjct: 500  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 559

Query: 184  KDGDKEQN-------------SELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD 230
            +    E                 L  +Y KLL +S+AR + L SL  ++   T EL WL+
Sbjct: 560  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 619

Query: 231  QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290
            ++ +  + +DWSDRN +  +++  Y   + R LE KE++I +L + GD+LL  +HP R +
Sbjct: 620  EKEEEEVGFDWSDRNTNMTAKKESYSALM-RELELKEKKIKELQNAGDRLLREDHPARPT 678

Query: 291  IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD 350
            +E+   A+   W   L L  C E+HLK    Y QF  DV++A+  L+K+   L +KY  D
Sbjct: 679  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 738

Query: 351  FKDRY-QIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-PLKP-IPVEAL 407
                  ++E LL++  D+++ L++Y+  + GL KR + VV LK R    P++  +P+ A+
Sbjct: 739  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 798

Query: 408  CDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPP------------ 454
            CD++  +  + +G    L      S W+++ S+G++   P+VCF++PP            
Sbjct: 799  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 858

Query: 455  ---------------TDPEALALADSLGSQYRSVRQKAAGSKRTL---QQRYEVLKTENP 496
                            D ++L    SL    + +R  +  + RTL   +QR  +   E  
Sbjct: 859  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 918

Query: 497  -----GDASDLQG--------------------RQLLAGLDKVASDLDRQEKAITGI--- 528
                  D+ D  G                    +QLL  L++ A +  R ++ I+ +   
Sbjct: 919  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 978

Query: 529  --------------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI 574
                          LR PL++  A ++ A+R  + +    E+  +     R +AE E  +
Sbjct: 979  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1037

Query: 575  QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH 634
                 S   P LR+ +E T  K E +  L  +  EK+   + + +  Q + E+L  HE  
Sbjct: 1038 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1097

Query: 635  LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC 694
            L +   VP +   L++    L  +  + +AQ+     +   L+ A++    L  R  E  
Sbjct: 1098 LKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1157

Query: 695  PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEP 754
             ++ER    V +L +R+  +  Q + R + L+       ++    D +  +L      + 
Sbjct: 1158 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1217

Query: 755  Q-----ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLR 809
            Q       DS +  E +L+ ++ LL+EI    ++V++    ++QY  A+KDYEL+    +
Sbjct: 1218 QIQAMPLADSQAVRE-QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1276

Query: 810  SLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQ 869
            + L+      +  +K+ ++QS +  V +E   L   ++E+  +  Q ++ +   L  + +
Sbjct: 1277 AQLE----PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1332

Query: 870  QPEVEVTHETLQRNRPDSGVEEAWKIRKELDE-ETERRRQLENEVKSTQEEIWTLRNQGP 928
            +  +       +R R  + VE A + +++L E   + + Q E E K  Q+ +        
Sbjct: 1333 EERLAEQQRAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-------- 1383

Query: 929  QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988
            QE VVR+E                      + Q + + +QEEL+ L+ Q    E + +  
Sbjct: 1384 QEEVVRRE------------------EAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKAR 1424

Query: 989  GQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRA 1048
              E   +  LRIE      +E+  +R +LEA  RQ+G  E E+  L+ R      E++ A
Sbjct: 1425 QAEAAERSRLRIE------EEIRVVRLQLEATERQRGGAEGELQALRARA-----EEAEA 1473

Query: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDK---LKRLEKER 1105
            Q++  ++E  +L+   Q E+     Q   Q + +L  + + E    ++K   L+ LE+ R
Sbjct: 1474 QKRQAQEEAERLRRQVQDES-----QRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1528

Query: 1106 AMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEEN 1165
              AE         +VE+    +  +    R  E E    RAS  EKT  L +  +L+EE+
Sbjct: 1529 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--SLQEEH 1586

Query: 1166 AKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSEL-EALRRRGP 1224
              V    ++RE          E      +  E ER    AE +L  +Q +  EALR R  
Sbjct: 1587 VAVA---QLRE----------EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1633

Query: 1225 QVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
              EV +  K + + + + + E+  +  R     + + + + +L   +L+K+ Q  + T  
Sbjct: 1634 AEEVAQ-QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1692

Query: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
            Q    E  QE+++ + + +  E+    + +L EE+  ++  E   A+Q+ Q    E    
Sbjct: 1693 QRLAAE--QELIRLRAETEQGEQ----QRQLLEEELARLQREAAAATQKRQELEAELAKV 1746

Query: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
            R +  V+     R EEE    +E S   + ++ E  +  +L  E  RL+    E +RQ  
Sbjct: 1747 RAEMEVLLASKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQ-R 1803

Query: 1405 ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRL 1464
            +L  E  AR+ AE E + L ++LAA+     EA    T  +  + +++ +  R   L RL
Sbjct: 1804 QLAEEDAARQRAEAE-RVLAEKLAAI----GEATRLKTEAEIALKEKEAENER---LRRL 1855

Query: 1465 QLEEEQHRRQLLEGELE---TLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518
              +E   RR+L E   +    +  +LA L KA   E++ +  L E    ++   E+EI  
Sbjct: 1856 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1915

Query: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578
            LK+S E+ +  K EL++E+ R+ +   +     SK   EL+  R+     + ER+  + E
Sbjct: 1916 LKASFEKAAAGKAELELELGRIRSNAEDT--LRSKEQAELEAARQRQLAAEEERRRREAE 1973

Query: 1579 TR---RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDE 1635
             R    L +E   A      L  +    +      RL     E +  ++L   ++     
Sbjct: 1974 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE-RAEQESARQLQLAQEAAQKR 2032

Query: 1636 LQKRLGSVAVKREQRENHLRRSI 1658
            LQ    + A   +Q+E  L++++
Sbjct: 2033 LQAEEKAHAFAVQQKEQELQQTL 2055



 Score =  187 bits (476), Expect = 6e-47
 Identities = 333/1478 (22%), Positives = 606/1478 (41%), Gaps = 254/1478 (17%)

Query: 475  QKAAGSKRTLQQRYEVLKTENPGDASDLQGR--QLLAGLDKVASDLDRQEKAITGILRPP 532
            + A   +R L + +   K +   +A +LQ R  + +   ++ A D  +Q+++I   L+  
Sbjct: 1352 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1411

Query: 533  LEQGRAVQDSAERAKDLKNITNELLRIEPE------------KTRSTAEGE--------- 571
             +   A  +   +A+  +      LRIE E            + R  AEGE         
Sbjct: 1412 RQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1469

Query: 572  -AFIQALPGSGTTPLLRTRVED-TNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWEL-- 627
             A  Q          LR +V+D + RK +  ++L    + + + A   +++LQ   EL  
Sbjct: 1470 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1529

Query: 628  -LATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTL 686
                 E  L Q + V  + +V  +      +   ELQ++++   E    L+ + Q     
Sbjct: 1530 QAEEAERRLRQAE-VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1588

Query: 687  ASRFQEHCPDLERQEAEVHKLGQRFNN--------------LRQQVERRAQSLQSAKAAY 732
             ++ +E      +Q+AE  +  +                  LR Q E  AQ    A+A  
Sbjct: 1589 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1648

Query: 733  EHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR----EQEVQKIC 788
            E   +  +   +        E Q        E +L+ Q+ L +  A +    EQE+ ++ 
Sbjct: 1649 E---KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1705

Query: 789  ANSQQYQQ-------------------AVKDYELEAEKLRSLLDLENGRSSHVSKRARLQ 829
            A ++Q +Q                     K  ELEAE  +   ++E   +S        +
Sbjct: 1706 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765

Query: 830  SPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNR----P 885
            S + K K+   A A +F E+ A    RL+ L       RQ  E +   +  +  R     
Sbjct: 1766 STSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1824

Query: 886  DSGVEEAWKIR-------KELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVL 938
             + + EA +++       KE + E ER R+L  +    +  +     Q   +   R   L
Sbjct: 1825 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1884

Query: 939  KKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVL 998
            +K  D  LE     ++ TL + +     ++EE+ AL+        E    G+  +  E+ 
Sbjct: 1885 RKASDSELERQKGLVEDTLRQRRQ----VEEEILALKASF-----EKAAAGKAELELELG 1935

Query: 999  RIEPDRAQADEVLQLRE--ELEALRRQKGARE-----------------AEVLLLQQRVA 1039
            RI   R+ A++ L+ +E  ELEA R+++ A E                 AE    +QR A
Sbjct: 1936 RI---RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1992

Query: 1040 ALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK--------QEEEL 1091
            AL EE  R + KV E   ++ + + +   + Q  QE  Q++ Q  EK        +E+EL
Sbjct: 1993 AL-EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2051

Query: 1092 S-FLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE 1150
               LQ +   L++ R  AE      E  + E     ERE +   RQ E EA + + S  E
Sbjct: 2052 QQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVE-EAERLKQSAEE 2109

Query: 1151 KTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLR 1210
            + +   +  A  E+  K   QE  R       +A++E A LR +        + A+ ++ 
Sbjct: 2110 QAQARAQAQAAAEKLRKEAEQEAAR-------RAQAEQAALRQK--------QAADAEME 2154

Query: 1211 SYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE---MEKELQRLREEIVDKTRLIERCDL 1267
             ++   E   R+  QVE +  T  +   +TD +   +++ELQRL+ E  +  R   + + 
Sbjct: 2155 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2214

Query: 1268 EIYQLKKEIQALKDTKPQVQT---------KEVVQEILQFQEDP--QTKEEVASLRAKLS 1316
            E++ ++ +++ L   K +++          K+  Q  LQ + +   Q  EE A L     
Sbjct: 2215 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2274

Query: 1317 E----EQKKQVDLERERASQEEQIARK------------EEELSRVKERVVQQEVVRYEE 1360
            E     Q  + DL ++RA  E+ +  K            E EL + ++ + Q++  R +E
Sbjct: 2275 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2334

Query: 1361 EPG-----LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQA--- 1412
            +       L  E   F  +++ E ++  ++ AE  RL+ R  E+ R     E + Q    
Sbjct: 2335 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2394

Query: 1413 -----------------------------RREAEREVQRLQQRLAALEQEEAEAREKVTH 1443
                                         R++++ + +RL++ +A LE+E+ + +++   
Sbjct: 2395 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2454

Query: 1444 TQKVVLQQDPQQAREHALLR----LQLEEEQHRRQLLEGE--LETLRRKLAALEKAEVKE 1497
             Q  +  ++ Q  ++  LL+    LQ      +  LL+ E  +E  + KL  L + EV +
Sbjct: 2455 LQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2512

Query: 1498 KVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKE 1557
               L E  Q ++   EQE QRL +S+EE  R + E +  V R +  L +LE    +  ++
Sbjct: 2513 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE---QQRRQQ 2569

Query: 1558 LDFLREENHKLQLERQNLQLETRRLQSE------INMAATET----RDLRNMTVADSGTN 1607
             + L EEN +L+ + Q L+ + R   +         +AAT+T    RD  +   A++   
Sbjct: 2570 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2629

Query: 1608 HDSRLWSLERELDDLKRLSKDKDLEIDELQK-RLGSVAV----KREQRENHL--RRSIV- 1659
            H      L R++   +RL +   L  +ELQ+   G   V    +RE   ++L  R SI  
Sbjct: 2630 HS--FDGLRRKV-SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG 2686

Query: 1660 VIHPDTGRELSPEEA-HRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKK 1718
            ++   T  +LS   A  R  L      + L +Q               S  + D    ++
Sbjct: 2687 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQ-------------AASGFLLDPVRNRR 2733

Query: 1719 FSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK 1756
             ++ EA++ G + P  + + ++ + ++       +GQ+
Sbjct: 2734 LTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQ 2771



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 40/110 (36%), Positives = 71/110 (64%), Gaps = 1/110 (0%)

Query: 1646 KREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNG 1705
            K   + +  +R +V++ P+TG+E+S  EA+R GLID   +++L  QEC+WEEI++   +G
Sbjct: 4115 KTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDG 4174

Query: 1706 -ESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSG 1754
               S+I DR+SG+++ I++A+    +  +  D+Y    +SI E A ++SG
Sbjct: 4175 VVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4224


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  413 bits (1062), Expect = e-115
 Identities = 426/1763 (24%), Positives = 785/1763 (44%), Gaps = 218/1763 (12%)

Query: 27   LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86
            L  ++ +LQ  A   E+ +   +A +QSD+  L  G+ P+      + +  ++ ++ +L 
Sbjct: 421  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 480

Query: 87   ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK------------QIYRLAVKEVD- 133
             D    K  +HPQG+ +   + +L ER+  +R ++             Q+ ++ ++ V  
Sbjct: 481  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 540

Query: 134  -PQVNWAAL---------VEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLA 183
             P++  + L         VEE   +++   +G DLP V+ Q+  H   H  ++     + 
Sbjct: 541  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 600

Query: 184  KDGDKEQN-------------SELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD 230
            +    E                 L  +Y KLL +S+AR + L SL  ++   T EL WL+
Sbjct: 601  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 660

Query: 231  QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290
            ++ +  + +DWSDRN +  +++  Y   + R LE KE++I +L + GD+LL  +HP R +
Sbjct: 661  EKEEEEVGFDWSDRNTNMTAKKESYSALM-RELELKEKKIKELQNAGDRLLREDHPARPT 719

Query: 291  IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD 350
            +E+   A+   W   L L  C E+HLK    Y QF  DV++A+  L+K+   L +KY  D
Sbjct: 720  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 779

Query: 351  FKDRY-QIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-PLKP-IPVEAL 407
                  ++E LL++  D+++ L++Y+  + GL KR + VV LK R    P++  +P+ A+
Sbjct: 780  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 839

Query: 408  CDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPP------------ 454
            CD++  +  + +G    L      S W+++ S+G++   P+VCF++PP            
Sbjct: 840  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 899

Query: 455  ---------------TDPEALALADSLGSQYRSVRQKAAGSKRTL---QQRYEVLKTENP 496
                            D ++L    SL    + +R  +  + RTL   +QR  +   E  
Sbjct: 900  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 959

Query: 497  -----GDASDLQG--------------------RQLLAGLDKVASDLDRQEKAITGI--- 528
                  D+ D  G                    +QLL  L++ A +  R ++ I+ +   
Sbjct: 960  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 1019

Query: 529  --------------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI 574
                          LR PL++  A ++ A+R  + +    E+  +     R +AE E  +
Sbjct: 1020 RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1078

Query: 575  QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH 634
                 S   P LR+ +E T  K E +  L  +  EK+   + + +  Q + E+L  HE  
Sbjct: 1079 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1138

Query: 635  LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC 694
            L +   VP +   L++    L  +  + +AQ+     +   L+ A++    L  R  E  
Sbjct: 1139 LKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1198

Query: 695  PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEP 754
             ++ER    V +L +R+  +  Q + R + L+       ++    D +  +L      + 
Sbjct: 1199 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1258

Query: 755  Q-----ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLR 809
            Q       DS +  E +L+ ++ LL+EI    ++V++    ++QY  A+KDYEL+    +
Sbjct: 1259 QIQAMPLADSQAVRE-QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1317

Query: 810  SLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQ 869
            + L+      +  +K+ ++QS +  V +E   L   ++E+  +  Q ++ +   L  + +
Sbjct: 1318 AQLE----PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1373

Query: 870  QPEVEVTHETLQRNRPDSGVEEAWKIRKELDE-ETERRRQLENEVKSTQEEIWTLRNQGP 928
            +  +       +R R  + VE A + +++L E   + + Q E E K  Q+ +        
Sbjct: 1374 EERLAEQQRAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-------- 1424

Query: 929  QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988
            QE VVR+E                      + Q + + +QEEL+ L+ Q    E + +  
Sbjct: 1425 QEEVVRRE------------------EAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKAR 1465

Query: 989  GQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRA 1048
              E   +  LRIE      +E+  +R +LEA  RQ+G  E E+  L+ R      E++ A
Sbjct: 1466 QAEAAERSRLRIE------EEIRVVRLQLEATERQRGGAEGELQALRARA-----EEAEA 1514

Query: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDK---LKRLEKER 1105
            Q++  ++E  +L+   Q E+     Q   Q + +L  + + E    ++K   L+ LE+ R
Sbjct: 1515 QKRQAQEEAERLRRQVQDES-----QRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1569

Query: 1106 AMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEEN 1165
              AE         +VE+    +  +    R  E E    RAS  EKT  L +  +L+EE+
Sbjct: 1570 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--SLQEEH 1627

Query: 1166 AKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSEL-EALRRRGP 1224
              V    ++RE          E      +  E ER    AE +L  +Q +  EALR R  
Sbjct: 1628 VAVA---QLRE----------EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1674

Query: 1225 QVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
              EV +  K + + + + + E+  +  R     + + + + +L   +L+K+ Q  + T  
Sbjct: 1675 AEEVAQ-QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1733

Query: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
            Q    E  QE+++ + + +  E+    + +L EE+  ++  E   A+Q+ Q    E    
Sbjct: 1734 QRLAAE--QELIRLRAETEQGEQ----QRQLLEEELARLQREAAAATQKRQELEAELAKV 1787

Query: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
            R +  V+     R EEE    +E S   + ++ E  +  +L  E  RL+    E +RQ  
Sbjct: 1788 RAEMEVLLASKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQ-R 1844

Query: 1405 ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRL 1464
            +L  E  AR+ AE E + L ++LAA+     EA    T  +  + +++ +  R   L RL
Sbjct: 1845 QLAEEDAARQRAEAE-RVLAEKLAAI----GEATRLKTEAEIALKEKEAENER---LRRL 1896

Query: 1465 QLEEEQHRRQLLEGELE---TLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518
              +E   RR+L E   +    +  +LA L KA   E++ +  L E    ++   E+EI  
Sbjct: 1897 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1956

Query: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578
            LK+S E+ +  K EL++E+ R+ +   +     SK   EL+  R+     + ER+  + E
Sbjct: 1957 LKASFEKAAAGKAELELELGRIRSNAEDT--LRSKEQAELEAARQRQLAAEEERRRREAE 2014

Query: 1579 TR---RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDE 1635
             R    L +E   A      L  +    +      RL     E +  ++L   ++     
Sbjct: 2015 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE-RAEQESARQLQLAQEAAQKR 2073

Query: 1636 LQKRLGSVAVKREQRENHLRRSI 1658
            LQ    + A   +Q+E  L++++
Sbjct: 2074 LQAEEKAHAFAVQQKEQELQQTL 2096



 Score =  187 bits (476), Expect = 6e-47
 Identities = 333/1478 (22%), Positives = 606/1478 (41%), Gaps = 254/1478 (17%)

Query: 475  QKAAGSKRTLQQRYEVLKTENPGDASDLQGR--QLLAGLDKVASDLDRQEKAITGILRPP 532
            + A   +R L + +   K +   +A +LQ R  + +   ++ A D  +Q+++I   L+  
Sbjct: 1393 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452

Query: 533  LEQGRAVQDSAERAKDLKNITNELLRIEPE------------KTRSTAEGE--------- 571
             +   A  +   +A+  +      LRIE E            + R  AEGE         
Sbjct: 1453 RQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1510

Query: 572  -AFIQALPGSGTTPLLRTRVED-TNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWEL-- 627
             A  Q          LR +V+D + RK +  ++L    + + + A   +++LQ   EL  
Sbjct: 1511 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1570

Query: 628  -LATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTL 686
                 E  L Q + V  + +V  +      +   ELQ++++   E    L+ + Q     
Sbjct: 1571 QAEEAERRLRQAE-VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1629

Query: 687  ASRFQEHCPDLERQEAEVHKLGQRFNN--------------LRQQVERRAQSLQSAKAAY 732
             ++ +E      +Q+AE  +  +                  LR Q E  AQ    A+A  
Sbjct: 1630 VAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEA 1689

Query: 733  EHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR----EQEVQKIC 788
            E   +  +   +        E Q        E +L+ Q+ L +  A +    EQE+ ++ 
Sbjct: 1690 E---KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1746

Query: 789  ANSQQYQQ-------------------AVKDYELEAEKLRSLLDLENGRSSHVSKRARLQ 829
            A ++Q +Q                     K  ELEAE  +   ++E   +S        +
Sbjct: 1747 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806

Query: 830  SPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNR----P 885
            S + K K+   A A +F E+ A    RL+ L       RQ  E +   +  +  R     
Sbjct: 1807 STSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1865

Query: 886  DSGVEEAWKIR-------KELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVL 938
             + + EA +++       KE + E ER R+L  +    +  +     Q   +   R   L
Sbjct: 1866 LAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1925

Query: 939  KKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVL 998
            +K  D  LE     ++ TL + +     ++EE+ AL+        E    G+  +  E+ 
Sbjct: 1926 RKASDSELERQKGLVEDTLRQRRQ----VEEEILALKASF-----EKAAAGKAELELELG 1976

Query: 999  RIEPDRAQADEVLQLRE--ELEALRRQKGARE-----------------AEVLLLQQRVA 1039
            RI   R+ A++ L+ +E  ELEA R+++ A E                 AE    +QR A
Sbjct: 1977 RI---RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2033

Query: 1040 ALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK--------QEEEL 1091
            AL EE  R + KV E   ++ + + +   + Q  QE  Q++ Q  EK        +E+EL
Sbjct: 2034 AL-EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2092

Query: 1092 S-FLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE 1150
               LQ +   L++ R  AE      E  + E     ERE +   RQ E EA + + S  E
Sbjct: 2093 QQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVE-EAERLKQSAEE 2150

Query: 1151 KTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLR 1210
            + +   +  A  E+  K   QE  R       +A++E A LR +        + A+ ++ 
Sbjct: 2151 QAQARAQAQAAAEKLRKEAEQEAAR-------RAQAEQAALRQK--------QAADAEME 2195

Query: 1211 SYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE---MEKELQRLREEIVDKTRLIERCDL 1267
             ++   E   R+  QVE +  T  +   +TD +   +++ELQRL+ E  +  R   + + 
Sbjct: 2196 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2255

Query: 1268 EIYQLKKEIQALKDTKPQVQT---------KEVVQEILQFQEDP--QTKEEVASLRAKLS 1316
            E++ ++ +++ L   K +++          K+  Q  LQ + +   Q  EE A L     
Sbjct: 2256 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2315

Query: 1317 E----EQKKQVDLERERASQEEQIARK------------EEELSRVKERVVQQEVVRYEE 1360
            E     Q  + DL ++RA  E+ +  K            E EL + ++ + Q++  R +E
Sbjct: 2316 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2375

Query: 1361 EPG-----LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQA--- 1412
            +       L  E   F  +++ E ++  ++ AE  RL+ R  E+ R     E + Q    
Sbjct: 2376 DKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK 2435

Query: 1413 -----------------------------RREAEREVQRLQQRLAALEQEEAEAREKVTH 1443
                                         R++++ + +RL++ +A LE+E+ + +++   
Sbjct: 2436 QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL 2495

Query: 1444 TQKVVLQQDPQQAREHALLR----LQLEEEQHRRQLLEGE--LETLRRKLAALEKAEVKE 1497
             Q  +  ++ Q  ++  LL+    LQ      +  LL+ E  +E  + KL  L + EV +
Sbjct: 2496 LQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2553

Query: 1498 KVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKE 1557
               L E  Q ++   EQE QRL +S+EE  R + E +  V R +  L +LE    +  ++
Sbjct: 2554 AQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE---QQRRQQ 2610

Query: 1558 LDFLREENHKLQLERQNLQLETRRLQSE------INMAATET----RDLRNMTVADSGTN 1607
             + L EEN +L+ + Q L+ + R   +         +AAT+T    RD  +   A++   
Sbjct: 2611 EELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPE 2670

Query: 1608 HDSRLWSLERELDDLKRLSKDKDLEIDELQK-RLGSVAV----KREQRENHL--RRSIV- 1659
            H      L R++   +RL +   L  +ELQ+   G   V    +RE   ++L  R SI  
Sbjct: 2671 HS--FDGLRRKV-SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAG 2727

Query: 1660 VIHPDTGRELSPEEA-HRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDRKSGKK 1718
            ++   T  +LS   A  R  L      + L +Q               S  + D    ++
Sbjct: 2728 LLLKATNEKLSVYAALQRQLLSPGTALILLEAQ-------------AASGFLLDPVRNRR 2774

Query: 1719 FSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK 1756
             ++ EA++ G + P  + + ++ + ++       +GQ+
Sbjct: 2775 LTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQ 2812



 Score = 85.1 bits (209), Expect = 5e-16
 Identities = 40/110 (36%), Positives = 71/110 (64%), Gaps = 1/110 (0%)

Query: 1646 KREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNG 1705
            K   + +  +R +V++ P+TG+E+S  EA+R GLID   +++L  QEC+WEEI++   +G
Sbjct: 4156 KTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDG 4215

Query: 1706 -ESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSG 1754
               S+I DR+SG+++ I++A+    +  +  D+Y    +SI E A ++SG
Sbjct: 4216 VVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4265


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score =  372 bits (956), Expect = e-102
 Identities = 371/1644 (22%), Positives = 744/1644 (45%), Gaps = 194/1644 (11%)

Query: 129  VKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHL--AKDG 186
            +K V   +NW   V+E   +L+   +G+DLP V+  +E H   H  ++     L  AK  
Sbjct: 279  MKFVQDLLNW---VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 335

Query: 187  DKEQNSELR-----------AKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKG 235
            + +  + L+           ++Y KLL  S+ +++HL +L +++ R TNEL WL+++ + 
Sbjct: 336  EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE 395

Query: 236  RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHM 295
             + YDWS+RN +  +R++ Y   + R L+ KEE I  +    +QLL   HP R +IEA+ 
Sbjct: 396  EVAYDWSERNTNI-ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 296  EAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDR- 354
             A+   W   L L  C E H+K    Y +F  D K+A + LR +   + +KY  D     
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 355  YQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRR-ETPLK-PIPVEALCDFEG 412
            +++E L++E  ++++ L +Y+  +  L  + + ++ LK R  + PLK  IP++A+CD+  
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 413  EQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR 471
             +  I +     L  N+  + W+++   GN+ + P+VCF +PP + EA+ LA+ +  QY+
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 472  SV----RQKAAGSKRTLQQRYEV-------------LKTENPGD----ASDLQGR----- 505
            +V     +     K  +   Y +             +KT  PG+     S+LQ R     
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 506  ------QLLAGLDKV------------------ASDLDRQEKAITGI------------- 528
                  Q+ +G D                    +++ + QE+++  +             
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754

Query: 529  ---------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579
                     +R PLE+   + +S  R  + + +  EL R++ +    T + E F      
Sbjct: 755  NCEDRLIRQIRTPLERD-DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA 813

Query: 580  SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDD 639
            S + P LR+ +    +    +  +     +K+   N + K+ Q +  L+  +E  L +++
Sbjct: 814  SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEE 873

Query: 640  TVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLER 699
             V      +++    L     E+  ++ +   +E  LQ AK  S  +   ++E   D + 
Sbjct: 874  AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDW 933

Query: 700  QEAEVHKLGQRFNNLRQQVERRAQSLQ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755
             + +  +L +R+ N+  Q++ R + L+    S K   + +H   D + Q   +    +  
Sbjct: 934  HKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 993

Query: 756  ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815
            + ++   + T+L  QK L+ EI  ++ ++ +    ++QY   VKDYEL+    R+++D  
Sbjct: 994  QPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-- 1051

Query: 816  NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875
              +     KR R+QS A  + +E   L  ++T +  +  Q ++    +L  L ++ E++ 
Sbjct: 1052 -SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEE-EIKR 1109

Query: 876  THETLQR-------NRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGP 928
              ET +         R  + V E  K+  ++ E      +L+ +    +EE+  +R    
Sbjct: 1110 CKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAE 1169

Query: 929  QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988
             E       L+K    V + S Q+++     +Q++      ELE +  +  A E+E    
Sbjct: 1170 NE-------LRKQQRNVEDISLQKIRAESEAKQYR-----RELETIVREKEAAEREL--- 1214

Query: 989  GQEYVVKEVLRIEPDRAQADE-VLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSR 1047
              E V +  +  E  RA  +E +L  R +LE     +   E  +      +  L ++K++
Sbjct: 1215 --ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNK 1272

Query: 1048 AQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQ--EEELSFLQDKLKRLEKER 1105
              E++  K      N+ +L    +Q+++D   Q Q+ EKQ  E++   L+ + K  E + 
Sbjct: 1273 LMEELRRKR----DNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARRKITEIQY 1328

Query: 1106 AMAEGKITVKEVLKVEKDAAT--------EREVSDLTRQYEDEAAKARASQREKTELLRK 1157
               E  + V  + +     A         +++  +L +Q ++  A  R ++++  EL  +
Sbjct: 1329 TCRENALPVCPITQATSCRAVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDMRELTYE 1388

Query: 1158 IWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELE 1217
            + AL+ E  K   +EK R +     +  + +  L+LEL  +++  +G  +QLR    +L 
Sbjct: 1389 LNALQLE--KTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLN 1446

Query: 1218 ALRRRGPQVEVKEVTKEVIKYKTDPEME-----KELQRLREEIVDKTRLIERCDLEIYQL 1272
              +  G   E  +   ++ K K + ++E      E  +L+ E+   TR     +  I  L
Sbjct: 1447 --QTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHL 1504

Query: 1273 KKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQ 1332
              +I + +D K +++  ++ Q     ++    KE+      +L +  K + +   +    
Sbjct: 1505 NSQIHSFRDEK-ELERLQICQ-----RKSDHLKEQFEKSHEQLLQNIKAEKENNDKIQRL 1558

Query: 1333 EEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAE-ASAFAESIDVELRQIDKLRAELRR 1391
             E++ +  E    +K++V  +E+ R   E  L  +   A +E+I +E + I + R E  +
Sbjct: 1559 NEELEKSNECAEMLKQKV--EELTRQNNETKLMMQRIQAESENIVLEKQTIQQ-RCEALK 1615

Query: 1392 LQRR--RTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVL 1449
            +Q    + +L    E L ++ +  ++ +R+++ L++ LA  +   +E ++K    Q +++
Sbjct: 1616 IQADGFKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQ-QNIII 1674

Query: 1450 QQDPQQARE-HALLRLQLEEE---QHRRQLLEGELETLRRK---------LAALEKAEVK 1496
            Q   ++ R  +A L    EE+   + + QL + +++ L  +         L  +E+    
Sbjct: 1675 QNTKKEVRNLNAELNASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLKTIEEQMTH 1734

Query: 1497 EKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSK 1556
             K+VL    Q E G  +Q  +  +  +E+   SK   + ++S +      L+  NS++ +
Sbjct: 1735 RKMVL---FQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQENSRAQE 1791

Query: 1557 ELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLE 1616
                L E N K +LERQ LQ    ++Q   +M A   +  + +         +  L + +
Sbjct: 1792 NAK-LCETNIK-ELERQ-LQQYREQMQQGQHMEANHYQKCQKL---------EDELIAQK 1839

Query: 1617 RELDDLKRLSKDKDLEIDELQKRL 1640
            RE+++LK   +  D +I E + +L
Sbjct: 1840 REVENLK---QKMDQQIKEHEHQL 1860



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 163/846 (19%), Positives = 350/846 (41%), Gaps = 117/846 (13%)

Query: 828  LQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFAL-NLLRQQPEVEVTHETLQRNRPD 886
            L   A + ++EE+      +EV  I R RL+N E  L   +R   E +  HE++ R    
Sbjct: 725  LLKSAEREEQEESVYNLYISEVRNI-RLRLENCEDRLIRQIRTPLERDDLHESVFR---- 779

Query: 887  SGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVL 946
              + E  K++KEL+       +L++++ +   +     +Q    S V          P L
Sbjct: 780  --ITEQEKLKKELE-------RLKDDLGTITNKCEEFFSQAAASSSV----------PTL 820

Query: 947  EESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQ 1006
                  + + + +    +    ++L+ + L L+  +        E +VK     E    +
Sbjct: 821  RSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQ------AAEALVK---LYETKLCE 871

Query: 1007 ADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQL 1066
             + V+  +  +E L        +EV   +Q   AL +E  +A  K    E+ K   +  L
Sbjct: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKA--KAISDEMFKTYKERDL 929

Query: 1067 EAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAAT 1126
            + ++ +     ++ DQL E+ +     + ++L+ LE           + + LK  +D  T
Sbjct: 930  DFDWHK-----EKADQLVERWQNVHVQIDNRLRDLEG----------IGKSLKYYRD--T 972

Query: 1127 EREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAES 1186
               + D  +Q E    K + +Q E ++ L    A +    K++V E   +        +S
Sbjct: 973  YHPLDDWIQQVETTQRKIQENQPENSKTL----ATQLNQQKMLVSEIEMK--------QS 1020

Query: 1187 EVANLRLELVEQERKYRGAEEQLRSYQSELEA-----LRRRGPQVEVKEVTKEVIKYKTD 1241
            ++   +    +     +  E Q  +Y++ +++     ++RR  Q     + +E +  +T 
Sbjct: 1021 KMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRT- 1079

Query: 1242 PEMEKELQRLREEIVDKTRLIERCDLEIYQLKKE-IQALKDTKPQVQTKEVVQEILQFQE 1300
                    R    +   T+ I+     + +L++E I+  K+T       +++Q       
Sbjct: 1080 --------RYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHGAYSDLLQR------ 1125

Query: 1301 DPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIAR----KEEELSRVKERV--VQQE 1354
               T  E + L  K+SE ++   +L+++++  EE++ +     E EL + +  V  +  +
Sbjct: 1126 QKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQRNVEDISLQ 1185

Query: 1355 VVRYEEEPG-LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQL----EELERE 1409
             +R E E    R E        +   R+++++R      + +R  +E  L     +LE  
Sbjct: 1186 KIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLNFRNQLEEN 1245

Query: 1410 RQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQ-------KVVLQQDPQQAREHALL 1462
               RR  E  ++R    L  LEQ++ +  E++   +       K++ Q +   A +  + 
Sbjct: 1246 TFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKDLAFQKQVA 1305

Query: 1463 RLQLEEEQH-----RRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQ 1517
              QL+E+Q      RR++ E +  T R    AL    + +         +++   +Q+ +
Sbjct: 1306 EKQLKEKQKIELEARRKITEIQY-TCREN--ALPVCPITQATSCRAVTGLQQEHDKQKAE 1362

Query: 1518 RLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQL 1577
             LK  ++E + + R+ + ++  L   L+ L+   + S ++   L+++  +     + L+L
Sbjct: 1363 ELKQQVDELTAANRKAEQDMRELTYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKL 1422

Query: 1578 ETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQ 1637
            E  R        + + R+L       +G   ++      +E  DLK++ ++  LE++ L 
Sbjct: 1423 ELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAM-----QEASDLKKIKRNYQLELESLN 1477

Query: 1638 KRLGSV 1643
               G +
Sbjct: 1478 HEKGKL 1483



 Score = 68.6 bits (166), Expect = 5e-11
 Identities = 112/564 (19%), Positives = 231/564 (40%), Gaps = 86/564 (15%)

Query: 529  LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRT 588
            L+  +++  A    AE+  D++ +T EL  ++ EKT S  +               LL+ 
Sbjct: 1364 LKQQVDELTAANRKAEQ--DMRELTYELNALQLEKTSSEEKAR-------------LLKD 1408

Query: 589  RVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVL 648
            ++++TN    + L+ L L  E+ D A   EK   Q    L    N               
Sbjct: 1409 KLDETN----NTLRCLKLELERKDQA---EKGYSQQLRELGRQLN--------------- 1446

Query: 649  DSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHK-- 706
                 +    A E   + S L ++++N Q   +  +    + Q     + R  A   K  
Sbjct: 1447 -----QTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRITRAHAVAEKNI 1501

Query: 707  --LGQRFNNLRQQVERRAQSLQSAKAAY--EHFHRGHDHVLQFLVSIPSYEPQETDSLSQ 762
              L  + ++ R + E     +   K+ +  E F + H+ +LQ + +    E +  D + +
Sbjct: 1502 QHLNSQIHSFRDEKELERLQICQRKSDHLKEQFEKSHEQLLQNIKA----EKENNDKIQR 1557

Query: 763  METKLKNQ-------KNLLDEIASREQE----VQKICANS-------QQYQQAVKDYELE 804
            +  +L+         K  ++E+  +  E    +Q+I A S       Q  QQ  +  +++
Sbjct: 1558 LNEELEKSNECAEMLKQKVEELTRQNNETKLMMQRIQAESENIVLEKQTIQQRCEALKIQ 1617

Query: 805  AEKLRSLLDLENGRSSHVSKRARLQSP-ATKVKEEEAALAAKFTEVYAINRQRLQNLEFA 863
            A+  +  L   N    H+ K+ + +     K+K  E  LA     V    ++  Q     
Sbjct: 1618 ADGFKDQLRSTN---EHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEFKQKCDQQ---- 1670

Query: 864  LNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTL 923
             N++ Q  + EV +   + N   +  EE  +  +++  +  + ++L N +K  Q+E+   
Sbjct: 1671 -NIIIQNTKKEVRNLNAELN---ASKEEKRRGEQKVQLQQAQVQELNNRLKKVQDELHLK 1726

Query: 924  RNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQ 983
              +  ++   RK VL +      ++S ++ ++ + +      + + ++  ++L   +L+Q
Sbjct: 1727 TIE--EQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLMESKVITENDISGIRLDFVSLQQ 1784

Query: 984  ETRDGGQEYVVKE--VLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAAL 1041
            E     +   + E  +  +E    Q  E +Q  + +EA   QK  +  + L+ Q+R    
Sbjct: 1785 ENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEANHYQKCQKLEDELIAQKREVEN 1844

Query: 1042 AEEKSRAQEKVTEKEVVKLQNDPQ 1065
             ++K   Q K  E ++V LQ + Q
Sbjct: 1845 LKQKMDQQIKEHEHQLVLLQCEIQ 1868



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 33/114 (28%), Positives = 61/114 (53%), Gaps = 8/114 (7%)

Query: 1637 QKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWE 1696
            ++ + ++ VK+  R       I V+   TG EL+  EA +  LI+ +++++L  Q+  W+
Sbjct: 2325 ERNISNLNVKKTHR-------ISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWK 2377

Query: 1697 EISVKGPNGESS-VIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELA 1749
            E       G SS ++ D K+G  F+I EA++ G +  A   +Y    +++ ELA
Sbjct: 2378 EAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELA 2431


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  311 bits (798), Expect = 3e-84
 Identities = 356/1658 (21%), Positives = 728/1658 (43%), Gaps = 226/1658 (13%)

Query: 129  VKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHL--AKDG 186
            +K V   +NW   V+E   +L+   +G+DLP V+  +E H   H  ++     L  AK  
Sbjct: 634  MKFVQDLLNW---VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 690

Query: 187  DKEQNSELR-----------AKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKG 235
            + +  + L+           ++Y KLL  S+ +++HL +L +++ R TNEL WL+++ + 
Sbjct: 691  EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE 750

Query: 236  RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHM 295
             + YDWS+RN +  +R++ Y   + R L+ KEE I  +    +QLL   HP R +IEA+ 
Sbjct: 751  EVAYDWSERNTNI-ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 809

Query: 296  EAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDR- 354
             A+   W   L L  C E H+K    Y +F  D K+A + LR +   + +KY  D     
Sbjct: 810  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 869

Query: 355  YQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRR-ETPLK-PIPVEALCDFEG 412
            +++E L++E  ++++ L +Y+  +  L  + + ++ LK R  + PLK  IP++A+CD+  
Sbjct: 870  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 929

Query: 413  EQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR 471
             +  I +     L  N+  + W+++   GN+ + P+VCF +PP + EA+ LA+ +  QY+
Sbjct: 930  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 989

Query: 472  SV----RQKAAGSKRTLQQRYEV-------------LKTENPGD----ASDLQGR----- 505
            +V     +     K  +   Y +             +KT  PG+     S+LQ R     
Sbjct: 990  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1049

Query: 506  ------QLLAGLDKV------------------ASDLDRQEKAITGI------------- 528
                  Q+ +G D                    +++ + QE+++  +             
Sbjct: 1050 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1109

Query: 529  ---------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579
                     +R PLE+   + +S  R  + + +  EL R++ +    T + E F      
Sbjct: 1110 NCEDRLIRQIRTPLERD-DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA 1168

Query: 580  SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDD 639
            S + P LR+ +    +    +  +     +K+   N + K+ Q +  L+  +E  L +++
Sbjct: 1169 SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEE 1228

Query: 640  TVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLER 699
             V      +++    L     E+  ++ +   +E  LQ AK  S  +   ++E   D + 
Sbjct: 1229 AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDW 1288

Query: 700  QEAEVHKLGQRFNNLRQQVERRAQSLQ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755
             + +  +L +R+ N+  Q++ R + L+    S K   + +H   D + Q   +    +  
Sbjct: 1289 HKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 1348

Query: 756  ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815
            + ++   + T+L  QK L+ EI  ++ ++ +    ++QY   VKDYEL+    R+++D  
Sbjct: 1349 QPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-- 1406

Query: 816  NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875
              +     KR R+QS A  + +E   L  ++T +  +     Q ++FA + L++  E E 
Sbjct: 1407 -SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL---MTQYIKFAGDSLKRLEEEEK 1462

Query: 876  THETLQRNRPDSGVE-EAW--KIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESV 932
            + E  ++   +   E + W   I K L +  +  +   ++ K + EEI T + Q      
Sbjct: 1463 SLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQ------ 1516

Query: 933  VRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEY 992
                         L E+ Q +Q  LA  +H +++  EE   L+ Q++ L++         
Sbjct: 1517 -------------LSEALQTIQLFLA--KHGDKMTDEERNELEKQVKTLQE-----SYNL 1556

Query: 993  VVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKV 1052
            +  E L+ +   +Q    +++ E++ A R+Q+          ++++  + +  ++ + ++
Sbjct: 1557 LFSESLK-QLQESQTSGDVKVEEKIVAERQQE---------YKEKLQGICDLLTQTENRL 1606

Query: 1053 TEKEVVKLQNDPQLE-AEYQQLQEDHQRQDQ-----LREKQEEELSFLQDKLKRLEKE-R 1105
               +   +  D  +E  +YQ  QE+ Q+  Q     L E  +   +FL++  ++L +E +
Sbjct: 1607 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1666

Query: 1106 AMAEGKITVKEV------LKVEKD-AATEREVSDLTRQYEDEAAKARASQREKTELLRKI 1158
            A+ E K+   ++      LK E+     ++ V+   ++  ++ A  +  +  KT++   +
Sbjct: 1667 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1726

Query: 1159 -WA----LEEENA----KVVVQEKVREIVRPDPKA---ESEVANLRLELVEQERKYRGAE 1206
             W      + E A    K V+++        D K+   E +  N  L   + + +    +
Sbjct: 1727 DWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ 1786

Query: 1207 EQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCD 1266
            E L     +++A   +   +  +     +        +EK+ Q L  E  +K +     +
Sbjct: 1787 ENLNQQYQKVKAQHEK---IISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----N 1839

Query: 1267 LEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQED--------PQTKEEVASLRAKLSEE 1318
            ++  ++  E    +  K    T  + +E+ +F  D         Q+++E+ +L A   + 
Sbjct: 1840 MKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDI 1899

Query: 1319 QKKQVDLERERASQEEQIARKEE-ELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDV 1377
                  L+R+++  E+ I+ K +     +    V +      +  G + + SA    +  
Sbjct: 1900 NGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQ- 1958

Query: 1378 ELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEA 1437
              R++D      R L  +   L   L++L  + Q   +A   +      LA L+  EA A
Sbjct: 1959 --RKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL------LAGLQACEATA 2010

Query: 1438 REKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKE 1497
             + ++    V    DP+       L+ QLEE     + L+G++ +   +  A+EK +   
Sbjct: 2011 SKHLSEPIAV----DPKN------LQRQLEE----TKALQGQISS---QQVAVEKLKKTA 2053

Query: 1498 KVVLSE--SVQVEKGDTEQEIQRLKSSLEEESRSKRE----LDVEVSR---LEARLSEL- 1547
            +V+L    S+   K D ++ +  +    E+ S+S  E    L + ++R   ++  L E+ 
Sbjct: 2054 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2113

Query: 1548 -EFHNSKSS-KELDFLREENHKLQ-LERQNLQLE--TRRLQSEINMAATETRDLRNMTVA 1602
                N +SS KE   +   +  LQ +  +N+ LE      QS IN    + +     T  
Sbjct: 2114 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2173

Query: 1603 DSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRL 1640
             + ++  +++  L     +     K+   +++EL+ ++
Sbjct: 2174 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2211



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 326/1767 (18%), Positives = 699/1767 (39%), Gaps = 272/1767 (15%)

Query: 16   TVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKV 75
            TV+ +   +K+  EL + +Q +A  + + + +TE  ++ +  +L +    E + +  QK+
Sbjct: 1619 TVELKKYQSKQ-EELQKDMQGSAQALAEVVKNTENFLKENGEKLSQ----EDKALIEQKL 1673

Query: 76   LDSEKLLYVL---------EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRG------- 119
             +++     L         E D  +   +K     + A  ++QL+E  T +         
Sbjct: 1674 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA--VKQLEESKTKIENLLDWLSN 1731

Query: 120  ----------KHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV---- 165
                      KHKQ+              +A+ EE  D++N     TD   VD QV    
Sbjct: 1732 VDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEE--DEVNGNLLETD---VDGQVGTTQ 1786

Query: 166  EEHNIFHNEVKA-----IGPHLA-----------------------KDGDKEQNSELRAK 197
            E  N  + +VKA     I  H A                       K+  ++   EL+  
Sbjct: 1787 ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVH 1846

Query: 198  YQKLLAASQARQQHLSSLQDYMQRC----TNELYWLDQQAKGRMQYDWSDRNLDYPSRRR 253
            Y+  LA S+ + +   SLQ+ +++     T   +WL Q  +     +    +++    + 
Sbjct: 1847 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1906

Query: 254  QYENFINRNLEAKEERINKLHSEGDQLLAAEHP--GRNSIEAHMEAVHADWKEYLNLLI- 310
            + +   + ++ + +  +  +   G+++L A      R+  +    A H + +  L+    
Sbjct: 1907 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1966

Query: 311  --------CEE--SHLKYMEDYHQFHEDVK-----DAQELLRKVDSDLNQKYGPDFKD-R 354
                    C    ++LK + D +Q +ED         Q         L++    D K+ +
Sbjct: 1967 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 2026

Query: 355  YQIE---LLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPI-----PVEA 406
             Q+E    L  ++  Q+  ++K +   + L      ++P K   +  L  I      +  
Sbjct: 2027 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2086

Query: 407  LCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSL 466
              +   E+  I+   S ++Q    E  + M +  + L          P +  AL     +
Sbjct: 2087 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQV----PLNSTAL---QDI 2139

Query: 467  GSQYRSVRQKAAGSKRTLQQRYEVLK----TENPGDASDLQGRQLLAGLDKVASDLDRQE 522
             S+   + Q  AG + ++    E +K    T +P  AS LQ +  +  L    S+   + 
Sbjct: 2140 ISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAK--MKDLSARFSEASHKH 2197

Query: 523  KAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGT 582
            K          E    +++   + +  +N++ +L      KT++  E +     +PG   
Sbjct: 2198 K----------ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVD-----VPGKDV 2242

Query: 583  TPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQ----- 637
            T L +   E T+   EH   L  L     ++++     L     L+    N+L++     
Sbjct: 2243 TELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH---GLPSDKALVLEKTNNLSKKFKEM 2299

Query: 638  DDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVE------------QNLQAAKQCSST 685
            +DT+ E    + S  ++L A    +++ KS + E              ++L  + + +  
Sbjct: 2300 EDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2359

Query: 686  LASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAA------------YE 733
            L  ++    P++++    V+  G    NL   V   A+++ + K+              E
Sbjct: 2360 LQEKWSLKTPEIQK----VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2415

Query: 734  HF--HRGHDHVLQFLVSIP-SYEPQET---DSLSQMETKLKNQKNLLDEIASREQEVQKI 787
             F  ++G   + + +  I   YE       D ++++ TKL   +   +E ++  Q +QK+
Sbjct: 2416 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKM 2475

Query: 788  CANSQQYQQAVKDYELEAEK--LRSLLDLENGRSSHVSKRARLQSPATKVKEE--EAALA 843
               + ++QQ     + EA K  +      E     +V+K   L+   T++ EE  +   A
Sbjct: 2476 NKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2535

Query: 844  AKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEET 903
             ++ ++      + Q L   L + RQQ   E ++   Q    ++ +++ W + KEL    
Sbjct: 2536 PRWKQMLTEIDSKWQELN-QLTIDRQQKLEESSNNLTQFQTVEAQLKQ-WLVEKELMVSV 2593

Query: 904  ERRRQLENEVKSTQ--------EEIWTLRNQGPQESVVRKEVLKKV-PDPVLEESFQQLQ 954
                 ++  + +TQ        +E  T + Q  Q +   + +L +   DP L    ++  
Sbjct: 2594 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2653

Query: 955  RTLAEE---------QHKNQLLQEELEALQLQ--LRALEQETRDGGQEYVVKEVLRIEPD 1003
              + ++            + + Q  +++ Q Q  LR+L  +  D   +      +   PD
Sbjct: 2654 AAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2713

Query: 1004 --RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQ 1061
                Q +   ++++E++  ++Q    +A   L +   A + EE  +A+     + ++K  
Sbjct: 2714 AMNQQLETAQKMKQEIQQEKKQIKVAQA---LCEDLSALVKEEYLKAELSRQLEGILKSF 2770

Query: 1062 NDPQLEAE--YQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLK 1119
             D + +AE   Q LQ       Q ++   +  ++L  K +   K   ++     ++ ++K
Sbjct: 2771 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2830

Query: 1120 VEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVR 1179
              KD +  + ++  +  YE   A       E   LL K    E    K  +Q ++  I  
Sbjct: 2831 DHKDFS--KTLTAQSHMYEKTIA-------EGENLLLKTQGSE----KAALQLQLNTI-- 2875

Query: 1180 PDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYK 1239
               K   +  N +++  E+E K + + E+   Y+ ++E L    P ++  +   E IK+ 
Sbjct: 2876 ---KTNWDTFNKQVK--ERENKLKESLEKALKYKEQVETL---WPWIDKCQNNLEEIKFC 2927

Query: 1240 TDPEMEK----ELQRLREEIVDKTRLIERCD------LEIYQLKKEIQALKDTKPQVQTK 1289
             DP   +    +L+ L++E+     ++E  +      L + ++ KE+    + K  +Q  
Sbjct: 2928 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV-VTDENKSLIQKV 2986

Query: 1290 EVVQEILQFQE-DPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQI---ARKEEELSR 1345
            ++V E L  ++   +   +      ++S+E K+Q+   +E+    + +   A   + L+ 
Sbjct: 2987 DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTM 3046

Query: 1346 VKERVVQQEVVRYEEEPGLRAEASAFAESIDVE-----LRQIDKLRAELRRLQRRRTE-- 1398
            ++ +    + ++++ +   R       E+ D +     L Q++ +  E   L ++  E  
Sbjct: 3047 LQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 3106

Query: 1399 --LERQLEELERERQARREAEREVQRLQQRLAALEQ--EEAEAREKVTHTQKVVLQQ--- 1451
              LE +L+ +   +   RE   +       L ++     +AE  +K   T K  L++   
Sbjct: 3107 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3166

Query: 1452 ---DPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKL-AALEKAEVKEKVVLSESVQV 1507
                   A +   + L  EE       ++ +LE L ++    L++A+ +E+ V     ++
Sbjct: 3167 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3226

Query: 1508 EKGDTE-QEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566
            E+  ++ +E   L    EE   S+  + +E   +  +L+  +           F +EE  
Sbjct: 3227 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV----------FQKEEIE 3276

Query: 1567 KLQLERQNLQ-LETRRLQSEINMAATE 1592
             LQ ++Q++  L    +QS     +T+
Sbjct: 3277 PLQGKQQDVNWLGQGLIQSAAKSTSTQ 3303



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 170/848 (20%), Positives = 339/848 (39%), Gaps = 150/848 (17%)

Query: 570  GEAFIQALPGSGTTPLLRTRVEDTNRKYEHL----LQLLDLAQEKVDVANRLEKSLQQ-- 623
            G+  IQ+   S +T  L   ++D N +++ L     Q     QE +    R + +L+   
Sbjct: 3289 GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLL 3348

Query: 624  SWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQK---SLLGEVEQNLQAAK 680
            SW ++ T E   NQ    P S+        E   +  ++Q QK    LL + +  ++  K
Sbjct: 3349 SW-MVDTEELVANQK---PPSA--------EFKVVKAQIQEQKLLQRLLDDRKSTVEVIK 3396

Query: 681  QCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHD 740
            +    +A+  +    D  +   ++  L  R+  L  + E R + L+      + FH   +
Sbjct: 3397 REGEKIATTAEP--ADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3454

Query: 741  HVLQFLVSIP----SYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQ 796
             + ++L +I     + EP  T + S++E ++   K L D+I +  + + +  +  Q  + 
Sbjct: 3455 PLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLK- 3512

Query: 797  AVKDYELEAEKLRSLLD------LENGRSSHVSKRARLQSPATKVK---EEEAALAAKFT 847
             V     + + ++S LD      +E    SH S+   LQ      K   E+E  L     
Sbjct: 3513 -VLSSREDKDMVQSKLDFSQVWYIEIQEKSH-SRSELLQQALCNAKIFGEDEVELMNWLN 3570

Query: 848  EVY-AINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPD------SGVE---------- 890
            EV+  +++  +Q+      L +QQ E+ V  E +   + +      +G+E          
Sbjct: 3571 EVHDKLSKLSVQDYSTE-GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3629

Query: 891  ---------------EAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRK 935
                           +  K+  ++ +  E+  QL   + ST EE+ T  ++      V  
Sbjct: 3630 LIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK------VEV 3683

Query: 936  EVLKKVPDPVLEESFQQLQ---RTLAEEQHKNQLLQEEL-EALQLQLRALEQETRDGGQE 991
            E+L      +  E   Q Q   + L +E   N+ L + L E     L  +    R+G ++
Sbjct: 3684 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3743

Query: 992  YVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEK 1051
             V ++  R    R  +D + Q  EE++A           +L  QQ   A   E S   E 
Sbjct: 3744 MVAEDNERY---RLVSDTITQKVEEIDAA----------ILRSQQFDQAADAELSWITE- 3789

Query: 1052 VTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGK 1111
             TEK+++ L  D +LE            QDQ   + + + +F  + L+  +    + +  
Sbjct: 3790 -TEKKLMSL-GDIRLE------------QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3835

Query: 1112 ITVKEVLKVEKDAATEREVSDLTRQYED--EAAKARASQREKTE-LLRKIWALEEENAKV 1168
              +      E+  + ++++  + + Y+   +    R  Q E+ + L+ + W   EE    
Sbjct: 3836 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3895

Query: 1169 VVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQ--- 1225
            + + +      P P  E E       L +Q+ ++R   E +  ++  ++ + + GPQ   
Sbjct: 3896 LTETQSIISQLPAPALEYET------LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3949

Query: 1226 --------VEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQ 1277
                    ++ K V  + +  +   +++K    L E I   T+  ++ D  +  L++ ++
Sbjct: 3950 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 4009

Query: 1278 ALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIA 1337
             L+                   + P    EV  ++ ++SE +   VD+E+ +   E    
Sbjct: 4010 RLR-------------------QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ 4050

Query: 1338 RKEEELSR 1345
            R EE ++R
Sbjct: 4051 RGEEMIAR 4058



 Score = 71.2 bits (173), Expect = 8e-12
 Identities = 264/1303 (20%), Positives = 495/1303 (37%), Gaps = 209/1303 (16%)

Query: 455  TDPEALALADSLGSQYRSVRQKAAGSKRTLQQ-RYEVLKTENPGDASDLQGRQLLAGLDK 513
            T P+ L L+   G    S+++K   +     Q + +V K     D +  Q  Q    +D+
Sbjct: 3943 TGPQLLELSPGEGF---SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3999

Query: 514  VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573
            +   L+R    I   LR P      V+   E+  + KN++ ++ +++P        GE  
Sbjct: 4000 ILESLER----IVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4055

Query: 574  IQALPGSG---TTPLLRTRVEDTNRKYEHLLQLLDLAQEK-VDVANRLEKSLQQSWELLA 629
            I    G+    +   ++ +++     +E++  L++  + K +DV    EK       L+ 
Sbjct: 4056 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4115

Query: 630  THENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASR 689
            T ++         +  R L+  G + + +  + +A +++  E++  LQ        L S 
Sbjct: 4116 TIKD-------TQDFIRDLEDPGIDPSVVKQQQEAAETIREEID-GLQEELDIVINLGSE 4167

Query: 690  FQEHC--PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLV 747
                C  PD    +  + +L   +++L +  + R   L+ A  A   +  G    LQ + 
Sbjct: 4168 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG----LQAVF 4223

Query: 748  SIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEK 807
                    +  S+S + T L+  K  ++E+             S+ YQQ     ++E E+
Sbjct: 4224 DWVDIAGGKLASMSPIGTDLETVKQQIEELKQ---------FKSEAYQQ-----QIEMER 4269

Query: 808  LRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLL 867
            L    +L   + +  S +  +Q P  ++K     L     E   INRQ    LE AL  L
Sbjct: 4270 LNHQAELLLKKVTEESDKHTVQDPLMELK-----LIWDSLEERIINRQ--HKLEGALLAL 4322

Query: 868  RQQPE--------VEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEE 919
             Q           +  T   L   +P  G  +A +I      E  +   L+N+V + Q  
Sbjct: 4323 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI------ELAKHHVLQNDVLAHQST 4376

Query: 920  IWTLRNQGPQ--ESVVRKEVLKKVPDPVLEESFQQLQRTLAE-EQHKNQL---------L 967
            +  +   G    ES   +E         LE   Q+ Q  L + EQ K QL          
Sbjct: 4377 VEAVNKAGNDLIESSAGEEASNL--QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGF 4434

Query: 968  QEELEALQLQLRALEQETRD----GGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQ 1023
              E+E LQ  L   E+        GG     KE L +  +   A E    +EE      Q
Sbjct: 4435 HGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA---KEETYKSLMQ 4491

Query: 1024 KGAR------EAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDH 1077
            KG +      ++    + Q +  L E+    + K+ E++  KL+    L  E+    +D 
Sbjct: 4492 KGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK-TKLEEALNLAMEFHNSLQDF 4550

Query: 1078 -----QRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSD 1132
                 Q +  L       L  L   L +++      E K+   EV    ++   E + + 
Sbjct: 4551 INWLTQAEQTLNVASRPSL-ILDTVLFQID------EHKVFANEV-NSHREQIIELDKTG 4602

Query: 1133 LTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVR-----EIVRPDPKAESE 1187
               +Y         SQ++   L++ +    +   + VVQ  V      +  R   K   E
Sbjct: 4603 THLKY--------FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4654

Query: 1188 VANLRLELVEQERKYRGAE-----------EQLRSYQSELEALRRRGPQVEVKEVTKEVI 1236
              +  +E +E+  K   +E            QL  ++   ++L  +    +    T   +
Sbjct: 4655 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4714

Query: 1237 KYKT-----DPEMEKELQRLRE-------EIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
            K KT     + +++  L  LR+       + V++   +E   L   Q    +QAL D   
Sbjct: 4715 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4774

Query: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
            +V+ +    + +    D      + + +A   E  K+   ++  + S  E I    ++ S
Sbjct: 4775 RVEPQLAEDQPVHGDID-LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS 4833

Query: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
             VK + +Q+   R+E    L          ++  LRQ ++  + +  L     E E+ L 
Sbjct: 4834 WVKVQ-MQELSTRWETVCALSISKQT---RLEAALRQAEEFHSVVHALLEWLAEAEQTLR 4889

Query: 1405 ---ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVT--HTQKVVLQQDPQQAREH 1459
                L  +  A R     + + ++ +  LE++ AE  +  T   T   +   D     +H
Sbjct: 4890 FHGVLPDDEDALRTL---IDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKH 4946

Query: 1460 --ALLRLQLEE-----EQHRRQL------LEGELETLRRKLAALEKAEV----KEKVVLS 1502
               ++R + EE     +QH+++L      L  + E L   LA L+ AE     K+K V+ 
Sbjct: 4947 WITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5006

Query: 1503 ESVQ------VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSK 1556
            + ++       E     +E+ R +  +++ +++ +    + S L++ +  L+   +   +
Sbjct: 5007 QEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKR 5066

Query: 1557 -ELDFLREENHKLQLERQN---------------LQLETRRLQSEINMAATETRDLRNMT 1600
                 L     + Q+E +N               L LE RR   ++N A     +LR   
Sbjct: 5067 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR---KLNDALDRLEELREF- 5122

Query: 1601 VADSGTNHDSRLW----------SLERELDDLKRLSKDKDLEI 1633
                  N D  +W             R +D  +R+ KD+D +I
Sbjct: 5123 -----ANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKI 5160



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 250/1287 (19%), Positives = 495/1287 (38%), Gaps = 203/1287 (15%)

Query: 454  PTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDK 513
            PTD EA+         + +  ++     + L+ +   L  ENP      + +Q+L  +D 
Sbjct: 2488 PTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDS 2547

Query: 514  VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573
               +L++                    D  ++ ++  N   +   +E +  +   E E  
Sbjct: 2548 KWQELNQ-----------------LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2590

Query: 574  IQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHEN 633
            +  L      P     + +T R+   +L L + A  K            Q  +L A  + 
Sbjct: 2591 VSVLGPLSIDP----NMLNTQRQQVQIL-LQEFATRK-----------PQYEQLTAAGQG 2634

Query: 634  HLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGE-------VEQNLQAAKQCSSTL 686
             L++    P    ++    ++LAA+    Q   SL G+       ++Q +  + Q  S L
Sbjct: 2635 ILSRPGEDPSLRGIVK---EQLAAVT---QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLL 2688

Query: 687  ASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFL 746
             S   +   DL+ + +    +    + + QQ+E   +  Q  +   +   +    + + L
Sbjct: 2689 RS-LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI-KVAQALCEDL 2746

Query: 747  VSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYE--LE 804
             ++   E  + +   Q+E  LK+ K++  +  +  Q +Q  CA+S Q+QQ  +D++  L+
Sbjct: 2747 SALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLD 2806

Query: 805  AEK---------------LRSLLDLENGRS------SHVSKRARLQSPATKVK---EEEA 840
             +K               L SL+      S      SH+ ++   +     +K    E+A
Sbjct: 2807 TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKA 2866

Query: 841  ALAAKFTEVY----AINRQ-------RLQNLEFALNLLRQ-----------QPEVEVTHE 878
            AL  +   +       N+Q         ++LE AL    Q           Q  +E    
Sbjct: 2867 ALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF 2926

Query: 879  TLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKS------TQEEIWTLRNQGPQESV 932
             L     ++ + +   ++KE+D+       L N   S        +E+ T  N       
Sbjct: 2927 CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDEN------- 2979

Query: 933  VRKEVLKKVPDPVLEESFQQ---LQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGG 989
              K +++KV D V E+   +   L+    + +   ++ +E    LQ     L+     G 
Sbjct: 2980 --KSLIQKV-DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGS 3036

Query: 990  QEYVVKEVLRIEPD-------RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALA 1042
            Q Y  K +  ++         + Q D   +L ++L  +        ++VLL   +V  +A
Sbjct: 3037 QAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL-VVEASDSKGTSDVLL---QVETIA 3092

Query: 1043 EEKSRAQEKVTEK---EVVKLQN----DPQLEAEYQQLQEDHQRQDQLR---------EK 1086
            +E S   ++V EK      KLQ        +   + Q  E     D +          +K
Sbjct: 3093 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3152

Query: 1087 QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDA----ATEREVSDLTRQYED--E 1140
            Q+E +     KL+ L      A    T K +L  E+ +      +R++  L++Q     +
Sbjct: 3153 QKETIKAFLKKLEALMASNDNANK--TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD 3210

Query: 1141 AAKARASQREKT-ELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQE 1199
             A+AR  Q E T + L + ++  +E + ++ + +  E  +     E+E  N +L + +  
Sbjct: 3211 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3270

Query: 1200 RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKT 1259
            +K     E L+  Q ++  L +   Q   K  + + +++  D ++    + L +++  + 
Sbjct: 3271 QKEE--IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD-DVNARWKTLNKKVAQRA 3327

Query: 1260 RLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQ 1319
              ++   L   + +  +++L      V T+E+V      Q+ P  + +V   +    +EQ
Sbjct: 3328 AQLQEALLHCGRFQDALESLLSW--MVDTEELVAN----QKPPSAEFKVVKAQI---QEQ 3378

Query: 1320 KKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVEL 1379
            K    L  +R S  E I R+ E+++   E   + ++                       L
Sbjct: 3379 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKI-----------------------L 3415

Query: 1380 RQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEARE 1439
            +Q+  L +    L  +     RQLE +    Q   E    ++ L + L  +E+       
Sbjct: 3416 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET---LEPLNEWLTTIEKRLVNCEP 3472

Query: 1440 KVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKV 1499
              T   K+    + Q A+  AL    +   +H  Q +    ++L+   +  +K  V+ K+
Sbjct: 3473 IGTQASKL----EEQIAQHKALEDDIINHNKHLHQAVSIG-QSLKVLSSREDKDMVQSKL 3527

Query: 1500 VLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVS-RLEARLSELEFHNSKSSKEL 1558
              S+   +E     QE    +S L +++    ++  E    L   L+E+    SK S + 
Sbjct: 3528 DFSQVWYIE----IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ- 3582

Query: 1559 DFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERE 1618
            D+  E   K Q E + LQ +    +  ++ A     +L   T  D       +L +++  
Sbjct: 3583 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKAR 3642

Query: 1619 LDDLKRLSKD--KDLE-IDELQKRLGS 1642
              D+ +LS D  K LE   +L +RL S
Sbjct: 3643 YKDITKLSTDVAKTLEQALQLARRLHS 3669



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 211/1170 (18%), Positives = 466/1170 (39%), Gaps = 171/1170 (14%)

Query: 585  LLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPES 644
            +++ ++E    +Y+      D+ +   DVA  LE++LQ +  L +THE      D V   
Sbjct: 3631 IIQDKLEAIKARYK------DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3684

Query: 645  SRVLDS---KGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQ- 700
                ++   KG+E    A + Q +   L +  +N +A     + ++S   E  P   R+ 
Sbjct: 3685 LLSYETQVLKGEE----ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG 3740

Query: 701  -EAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQF-------LVSIPSY 752
             E  V +  +R+  +   + ++ + + +A    + F +  D  L +       L+S+   
Sbjct: 3741 LEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDI 3800

Query: 753  EPQETDSLSQMET------KLKNQKNLLDEIASREQEVQKICANSQ------QYQQAVKD 800
              ++  + +Q++       ++   K+++D++     ++   C+  +      +  + +K+
Sbjct: 3801 RLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3860

Query: 801  Y----ELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQR 856
            Y    ++ +E+   L   ++  +        L    T+ +   + L A   E   + +Q+
Sbjct: 3861 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3920

Query: 857  LQNLEFALNLLRQQPEVEVTHET---LQRNRPDSG--VEEAW----KIRKELDEETERRR 907
             ++ +    +   +P ++  ++T   L    P  G  ++E +     +  ++ E+ ++R 
Sbjct: 3921 EEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRA 3980

Query: 908  QLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLL 967
               +E  S   +     +Q   ES+ R  +++++  P    S       + E+  +N+ +
Sbjct: 3981 VALDEAISQSTQFHDKIDQ-ILESLER--IVERLRQP---PSISAEVEKIKEQISENKNV 4034

Query: 968  QEELEALQ-----LQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRR 1022
              ++E LQ     L+ R  E   R GG +    + +  +  + + D+++ + E +  L  
Sbjct: 4035 SVDMEKLQPLYETLKQRGEEMIARSGGTD----KDISAKAVQDKLDQMVFIWENIHTLVE 4090

Query: 1023 QKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQ 1082
            ++ A+  +V+ L ++     +  S        ++ ++   DP ++          ++Q +
Sbjct: 4091 EREAKLLDVMELAEKF--WCDHMSLIVTIKDTQDFIRDLEDPGIDPSVV------KQQQE 4142

Query: 1083 LREKQEEELSFLQDKLK---RLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYED 1139
              E   EE+  LQ++L     L  E   A G          E D    ++  D      D
Sbjct: 4143 AAETIREEIDGLQEELDIVINLGSELIAACG----------EPDKPIVKKSIDELNSAWD 4192

Query: 1140 EAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLR-----LE 1194
               KA   + +K E        E   A V  Q+ ++ +      A  ++A++      LE
Sbjct: 4193 SLNKAWKDRIDKLE--------EAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4244

Query: 1195 LVEQE-RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKT-DPEMEKEL--QR 1250
             V+Q+  + +  + +    Q E+E L  +  ++ +K+VT+E  K+   DP ME +L    
Sbjct: 4245 TVKQQIEELKQFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDS 4303

Query: 1251 LREEIVDKTRLIERCDLEIYQLKKEIQ-----------ALKDTKPQVQTKEVVQEILQFQ 1299
            L E I+++   +E   L + Q +  +             L + KP     + ++  ++  
Sbjct: 4304 LEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE--IELA 4361

Query: 1300 EDPQTKEEVASLRAKLSEEQKKQVDLERERASQE-EQIARKEEELSRVKERVVQQEVVRY 1358
            +    + +V + ++ +    K   DL    A +E   +  K E L++  + V+++   R 
Sbjct: 4362 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4421

Query: 1359 EEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAER 1418
            ++              +D  LRQ      E+  LQ+  T+ ER L   +        A+ 
Sbjct: 4422 QQ--------------LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKE 4467

Query: 1419 EVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEG 1478
            ++    +  AA E +E         T K ++Q+  Q      L R     E +    ++ 
Sbjct: 4468 QLNVHMEVCAAFEAKE--------ETYKSLMQKGQQM-----LARCPKSAETN----IDQ 4510

Query: 1479 ELETLRRKLAALE------KAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRE 1532
            ++  L+ K  ++E      K +++E + L+        D    + + + +L   SR    
Sbjct: 4511 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4570

Query: 1533 LDVEVSRLEAR---LSELEFHN------SKSSKELDFLREENHKLQLERQNLQLETRRLQ 1583
            LD  + +++      +E+  H        K+   L +  ++   + +  +NL +  +   
Sbjct: 4571 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLI--KNLLISVQSRW 4628

Query: 1584 SEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEI----DELQKR 1639
             ++     E    R++  A          WS   E  +    S D +LEI    D+++ +
Sbjct: 4629 EKVVQRLVERG--RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ 4686

Query: 1640 LGSVAVKREQRENHLRRSIVVIHPDTGREL 1669
            L     K  Q+    + S+      TGR L
Sbjct: 4687 LAQ--HKEFQKSLGAKHSVYDTTNRTGRSL 4714



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 196/1134 (17%), Positives = 447/1134 (39%), Gaps = 143/1134 (12%)

Query: 599  HLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAM 658
            H    L  +++K+ + + L++ L++        E+ L Q +   E+   L++   ++  +
Sbjct: 1846 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELEN---LEAGADDINGL 1902

Query: 659  ACELQAQKSLLGEVEQN--------------LQAAKQCSSTLASRFQEHCPDLERQEAEV 704
              +L+ QKS   +V  +              L+AAK CS     +        E Q    
Sbjct: 1903 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1962

Query: 705  HKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQ-- 762
            H    RF +L  +      +L+     Y+H+    D     L  + + E   +  LS+  
Sbjct: 1963 HAT-DRFRSLYSKCNVLGNNLKDLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPI 2018

Query: 763  ------METKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLEN 816
                  ++ +L+  K L  +I+S++  V+K+   ++    A          ++  LD   
Sbjct: 2019 AVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIV 2078

Query: 817  GRSSHVSKRA-----RLQSPATKVKEEEAAL------------AAKFTEVYAINRQRLQ- 858
            GR   +SK       +LQ   T+    +  L            + K      +N   LQ 
Sbjct: 2079 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQD 2138

Query: 859  ----NLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVK 914
                N+    ++  +Q  +   +E +++    +    A  ++ ++ + + R  +  ++ K
Sbjct: 2139 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2198

Query: 915  STQEEIWTLRN------------QGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE-Q 961
             T  ++  L+             Q   E+  +      VP   + E  Q +Q + +E  +
Sbjct: 2199 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2258

Query: 962  HKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPD-RAQADEVLQLREELEAL 1020
            HK     + LE L   L+ +        +  V+++   +    +   D + + +E + + 
Sbjct: 2259 HK-----KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC 2313

Query: 1021 RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVK-LQNDPQLEAEYQQLQEDHQR 1079
            + Q  A +  V  L+  +    ++    Q     +++ K L++  +L+ ++     + Q+
Sbjct: 2314 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2373

Query: 1080 QDQLREKQEEELSFLQDKLKRLEKERA-----MAEGKITVKEVLKVEKDAAT-EREVSDL 1133
             +         +S +    K +   ++       EG  T  E     K   + +++++D+
Sbjct: 2374 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2433

Query: 1134 TRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRL 1193
            +  YED     +    E    L K+   +EE++   + + ++++ +   K +   A    
Sbjct: 2434 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS--AMMQWLQKMNKTATKWQQTPAPTDT 2491

Query: 1194 ELVE-QERKYRGAEEQLRSYQSELEALRRRGPQ-VEVKEVTKEVIKYKTD-PEMEKELQR 1250
            E V+ Q  + +  E +L+   ++++ L+ +  + +E    T E  ++K    E++ + Q 
Sbjct: 2492 EAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQE 2551

Query: 1251 LREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDP-QTKEEVA 1309
            L +  +D+ + +E     + Q +     LK     V+ + +V  +     DP     +  
Sbjct: 2552 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQW--LVEKELMVSVLGPLSIDPNMLNTQRQ 2609

Query: 1310 SLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEAS 1369
             ++  L E   ++   E+  A+ +  ++R  E+ S ++  V +Q     ++   L  + S
Sbjct: 2610 QVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPS-LRGIVKEQLAAVTQKWDSLTGQLS 2668

Query: 1370 AFAESIDVELRQIDKLRAELRRLQRRRTELERQL--------------EELERERQARRE 1415
               + ID  + +  + ++ LR L  + ++L+ +L              ++LE  ++ ++E
Sbjct: 2669 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2728

Query: 1416 AERE------VQRLQQRLAALEQE---------------------EAEAREKVTHTQKVV 1448
             ++E       Q L + L+AL +E                     E +A   V H Q   
Sbjct: 2729 IQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSAC 2788

Query: 1449 L--QQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQ 1506
                Q  Q +R+        +EEQ++   +  +L+ L    + ++  +   K + ++S  
Sbjct: 2789 ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLE---SLIKDHKDFSKTLTAQSHM 2845

Query: 1507 VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566
             EK   E E   LK+   E++  + +L+   +  +    +++   +K  + L+  +   +
Sbjct: 2846 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE--KALKY 2903

Query: 1567 KLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELD 1620
            K Q+E          L   I+       +++       G N  ++L SL++E+D
Sbjct: 2904 KEQVE---------TLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMD 2948



 Score = 35.4 bits (80), Expect = 0.49
 Identities = 67/320 (20%), Positives = 133/320 (41%), Gaps = 57/320 (17%)

Query: 26   ELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVL 85
            +L E +E+ +K+ D  E  I +   K+++ LA+ +E           QK L ++  +Y  
Sbjct: 4658 KLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKE----------FQKSLGAKHSVY-- 4704

Query: 86   EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKE-------------- 131
              D          +   +A+D  +L + ++ LR K   I   +V+               
Sbjct: 4705 --DTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4762

Query: 132  ---VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNE-------VKAIGPH 181
               +   ++W   VE +L +  +Q    D+ LV + ++ H  F  E       V+A+   
Sbjct: 4763 TDALQALIDWLYRVEPQLAE--DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4820

Query: 182  LAK--DGDKEQNS-------ELRAKYQKLLAASQARQQHLSSL----QDYMQRCTNELYW 228
              +  +G ++ +S       EL  +++ + A S ++Q  L +     +++       L W
Sbjct: 4821 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4880

Query: 229  LDQQAKG-RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPG 287
            L +  +  R      D      +   Q++ F+ + LE K   +NK  + GD +LA  HP 
Sbjct: 4881 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKK-LEEKRAELNKATTMGDTVLAICHPD 4939

Query: 288  R-NSIEAHMEAVHADWKEYL 306
               +I+  +  + A ++E L
Sbjct: 4940 SITTIKHWITIIRARFEEVL 4959



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 70/347 (20%), Positives = 138/347 (39%), Gaps = 43/347 (12%)

Query: 110  LKERVTNLRGKHKQIYRLAVKE----VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV 165
            L+ER+ N + K +    LA+ +    +D  + W    E  L +   +  G D   ++ ++
Sbjct: 4304 LEERIINRQHKLEGAL-LALGQFQHALDELLAWLTHTEGLLSE--QKPVGGDPKAIEIEL 4360

Query: 166  EEHNIFHNEVKA----------IGPHLAKDGDKEQNSELRAK-------YQKLLAASQAR 208
             +H++  N+V A           G  L +    E+ S L+ K       +Q +L  ++ R
Sbjct: 4361 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQR 4420

Query: 209  QQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLD-YPSRRRQYENF---INRNLE 264
            +Q L       +    E+  L Q      ++  + + L   P   ++  N    +    E
Sbjct: 4421 KQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4480

Query: 265  AKEERINKLHSEGDQLLA-AEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYH 323
            AKEE    L  +G Q+LA        +I+  +  +   W+     L   E   K  E  +
Sbjct: 4481 AKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKL--NERKTKLEEALN 4538

Query: 324  ---QFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQE---KVLDKYEDV 377
               +FH  ++D    L + +  LN    P       ++ +L ++D+ +     ++ + + 
Sbjct: 4539 LAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEVNSHREQ 4594

Query: 378  VQGLQKRGQQVVPLKYRRETPL-KPIPVEALCDFEG-EQGLISRGYS 422
            +  L K G  +     +++  L K + +     +E   Q L+ RG S
Sbjct: 4595 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4641



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 12/85 (14%)

Query: 103  IAEDIRQLKER-------VTNLRGKHKQIYRLAVK---EVDPQVNWAALVEEKLDKLNNQ 152
            I +DI  LKE+       +   + K ++   LA++    +   +NW    E+ L+  +  
Sbjct: 4508 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4567

Query: 153  SFGTDLPLVDHQVEEHNIFHNEVKA 177
            S   D  L   Q++EH +F NEV +
Sbjct: 4568 SLILDTVLF--QIDEHKVFANEVNS 4590


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  311 bits (798), Expect = 3e-84
 Identities = 356/1658 (21%), Positives = 728/1658 (43%), Gaps = 226/1658 (13%)

Query: 129  VKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHL--AKDG 186
            +K V   +NW   V+E   +L+   +G+DLP V+  +E H   H  ++     L  AK  
Sbjct: 645  MKFVQDLLNW---VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 701

Query: 187  DKEQNSELR-----------AKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKG 235
            + +  + L+           ++Y KLL  S+ +++HL +L +++ R TNEL WL+++ + 
Sbjct: 702  EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE 761

Query: 236  RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHM 295
             + YDWS+RN +  +R++ Y   + R L+ KEE I  +    +QLL   HP R +IEA+ 
Sbjct: 762  EVAYDWSERNTNI-ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820

Query: 296  EAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDR- 354
             A+   W   L L  C E H+K    Y +F  D K+A + LR +   + +KY  D     
Sbjct: 821  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880

Query: 355  YQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRR-ETPLK-PIPVEALCDFEG 412
            +++E L++E  ++++ L +Y+  +  L  + + ++ LK R  + PLK  IP++A+CD+  
Sbjct: 881  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940

Query: 413  EQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR 471
             +  I +     L  N+  + W+++   GN+ + P+VCF +PP + EA+ LA+ +  QY+
Sbjct: 941  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000

Query: 472  SV----RQKAAGSKRTLQQRYEV-------------LKTENPGD----ASDLQGR----- 505
            +V     +     K  +   Y +             +KT  PG+     S+LQ R     
Sbjct: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060

Query: 506  ------QLLAGLDKV------------------ASDLDRQEKAITGI------------- 528
                  Q+ +G D                    +++ + QE+++  +             
Sbjct: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120

Query: 529  ---------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579
                     +R PLE+   + +S  R  + + +  EL R++ +    T + E F      
Sbjct: 1121 NCEDRLIRQIRTPLERD-DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA 1179

Query: 580  SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDD 639
            S + P LR+ +    +    +  +     +K+   N + K+ Q +  L+  +E  L +++
Sbjct: 1180 SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEE 1239

Query: 640  TVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLER 699
             V      +++    L     E+  ++ +   +E  LQ AK  S  +   ++E   D + 
Sbjct: 1240 AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDW 1299

Query: 700  QEAEVHKLGQRFNNLRQQVERRAQSLQ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755
             + +  +L +R+ N+  Q++ R + L+    S K   + +H   D + Q   +    +  
Sbjct: 1300 HKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 1359

Query: 756  ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815
            + ++   + T+L  QK L+ EI  ++ ++ +    ++QY   VKDYEL+    R+++D  
Sbjct: 1360 QPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-- 1417

Query: 816  NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875
              +     KR R+QS A  + +E   L  ++T +  +     Q ++FA + L++  E E 
Sbjct: 1418 -SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL---MTQYIKFAGDSLKRLEEEEK 1473

Query: 876  THETLQRNRPDSGVE-EAW--KIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESV 932
            + E  ++   +   E + W   I K L +  +  +   ++ K + EEI T + Q      
Sbjct: 1474 SLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQ------ 1527

Query: 933  VRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEY 992
                         L E+ Q +Q  LA  +H +++  EE   L+ Q++ L++         
Sbjct: 1528 -------------LSEALQTIQLFLA--KHGDKMTDEERNELEKQVKTLQE-----SYNL 1567

Query: 993  VVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKV 1052
            +  E L+ +   +Q    +++ E++ A R+Q+          ++++  + +  ++ + ++
Sbjct: 1568 LFSESLK-QLQESQTSGDVKVEEKIVAERQQE---------YKEKLQGICDLLTQTENRL 1617

Query: 1053 TEKEVVKLQNDPQLE-AEYQQLQEDHQRQDQ-----LREKQEEELSFLQDKLKRLEKE-R 1105
               +   +  D  +E  +YQ  QE+ Q+  Q     L E  +   +FL++  ++L +E +
Sbjct: 1618 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1677

Query: 1106 AMAEGKITVKEV------LKVEKD-AATEREVSDLTRQYEDEAAKARASQREKTELLRKI 1158
            A+ E K+   ++      LK E+     ++ V+   ++  ++ A  +  +  KT++   +
Sbjct: 1678 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1737

Query: 1159 -WA----LEEENA----KVVVQEKVREIVRPDPKA---ESEVANLRLELVEQERKYRGAE 1206
             W      + E A    K V+++        D K+   E +  N  L   + + +    +
Sbjct: 1738 DWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ 1797

Query: 1207 EQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCD 1266
            E L     +++A   +   +  +     +        +EK+ Q L  E  +K +     +
Sbjct: 1798 ENLNQQYQKVKAQHEK---IISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----N 1850

Query: 1267 LEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQED--------PQTKEEVASLRAKLSEE 1318
            ++  ++  E    +  K    T  + +E+ +F  D         Q+++E+ +L A   + 
Sbjct: 1851 MKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDI 1910

Query: 1319 QKKQVDLERERASQEEQIARKEE-ELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDV 1377
                  L+R+++  E+ I+ K +     +    V +      +  G + + SA    +  
Sbjct: 1911 NGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQ- 1969

Query: 1378 ELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEA 1437
              R++D      R L  +   L   L++L  + Q   +A   +      LA L+  EA A
Sbjct: 1970 --RKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL------LAGLQACEATA 2021

Query: 1438 REKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKE 1497
             + ++    V    DP+       L+ QLEE     + L+G++ +   +  A+EK +   
Sbjct: 2022 SKHLSEPIAV----DPKN------LQRQLEE----TKALQGQISS---QQVAVEKLKKTA 2064

Query: 1498 KVVLSE--SVQVEKGDTEQEIQRLKSSLEEESRSKRE----LDVEVSR---LEARLSEL- 1547
            +V+L    S+   K D ++ +  +    E+ S+S  E    L + ++R   ++  L E+ 
Sbjct: 2065 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2124

Query: 1548 -EFHNSKSS-KELDFLREENHKLQ-LERQNLQLE--TRRLQSEINMAATETRDLRNMTVA 1602
                N +SS KE   +   +  LQ +  +N+ LE      QS IN    + +     T  
Sbjct: 2125 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2184

Query: 1603 DSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRL 1640
             + ++  +++  L     +     K+   +++EL+ ++
Sbjct: 2185 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2222



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 326/1767 (18%), Positives = 699/1767 (39%), Gaps = 272/1767 (15%)

Query: 16   TVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKV 75
            TV+ +   +K+  EL + +Q +A  + + + +TE  ++ +  +L +    E + +  QK+
Sbjct: 1630 TVELKKYQSKQ-EELQKDMQGSAQALAEVVKNTENFLKENGEKLSQ----EDKALIEQKL 1684

Query: 76   LDSEKLLYVL---------EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRG------- 119
             +++     L         E D  +   +K     + A  ++QL+E  T +         
Sbjct: 1685 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA--VKQLEESKTKIENLLDWLSN 1742

Query: 120  ----------KHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV---- 165
                      KHKQ+              +A+ EE  D++N     TD   VD QV    
Sbjct: 1743 VDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEE--DEVNGNLLETD---VDGQVGTTQ 1797

Query: 166  EEHNIFHNEVKA-----IGPHLA-----------------------KDGDKEQNSELRAK 197
            E  N  + +VKA     I  H A                       K+  ++   EL+  
Sbjct: 1798 ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVH 1857

Query: 198  YQKLLAASQARQQHLSSLQDYMQRC----TNELYWLDQQAKGRMQYDWSDRNLDYPSRRR 253
            Y+  LA S+ + +   SLQ+ +++     T   +WL Q  +     +    +++    + 
Sbjct: 1858 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1917

Query: 254  QYENFINRNLEAKEERINKLHSEGDQLLAAEHP--GRNSIEAHMEAVHADWKEYLNLLI- 310
            + +   + ++ + +  +  +   G+++L A      R+  +    A H + +  L+    
Sbjct: 1918 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1977

Query: 311  --------CEE--SHLKYMEDYHQFHEDVK-----DAQELLRKVDSDLNQKYGPDFKD-R 354
                    C    ++LK + D +Q +ED         Q         L++    D K+ +
Sbjct: 1978 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 2037

Query: 355  YQIE---LLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPI-----PVEA 406
             Q+E    L  ++  Q+  ++K +   + L      ++P K   +  L  I      +  
Sbjct: 2038 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2097

Query: 407  LCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSL 466
              +   E+  I+   S ++Q    E  + M +  + L          P +  AL     +
Sbjct: 2098 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQV----PLNSTAL---QDI 2150

Query: 467  GSQYRSVRQKAAGSKRTLQQRYEVLK----TENPGDASDLQGRQLLAGLDKVASDLDRQE 522
             S+   + Q  AG + ++    E +K    T +P  AS LQ +  +  L    S+   + 
Sbjct: 2151 ISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAK--MKDLSARFSEASHKH 2208

Query: 523  KAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGT 582
            K          E    +++   + +  +N++ +L      KT++  E +     +PG   
Sbjct: 2209 K----------ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVD-----VPGKDV 2253

Query: 583  TPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQ----- 637
            T L +   E T+   EH   L  L     ++++     L     L+    N+L++     
Sbjct: 2254 TELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH---GLPSDKALVLEKTNNLSKKFKEM 2310

Query: 638  DDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVE------------QNLQAAKQCSST 685
            +DT+ E    + S  ++L A    +++ KS + E              ++L  + + +  
Sbjct: 2311 EDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2370

Query: 686  LASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAA------------YE 733
            L  ++    P++++    V+  G    NL   V   A+++ + K+              E
Sbjct: 2371 LQEKWSLKTPEIQK----VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2426

Query: 734  HF--HRGHDHVLQFLVSIP-SYEPQET---DSLSQMETKLKNQKNLLDEIASREQEVQKI 787
             F  ++G   + + +  I   YE       D ++++ TKL   +   +E ++  Q +QK+
Sbjct: 2427 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKM 2486

Query: 788  CANSQQYQQAVKDYELEAEK--LRSLLDLENGRSSHVSKRARLQSPATKVKEE--EAALA 843
               + ++QQ     + EA K  +      E     +V+K   L+   T++ EE  +   A
Sbjct: 2487 NKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2546

Query: 844  AKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEET 903
             ++ ++      + Q L   L + RQQ   E ++   Q    ++ +++ W + KEL    
Sbjct: 2547 PRWKQMLTEIDSKWQELN-QLTIDRQQKLEESSNNLTQFQTVEAQLKQ-WLVEKELMVSV 2604

Query: 904  ERRRQLENEVKSTQ--------EEIWTLRNQGPQESVVRKEVLKKV-PDPVLEESFQQLQ 954
                 ++  + +TQ        +E  T + Q  Q +   + +L +   DP L    ++  
Sbjct: 2605 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2664

Query: 955  RTLAEE---------QHKNQLLQEELEALQLQ--LRALEQETRDGGQEYVVKEVLRIEPD 1003
              + ++            + + Q  +++ Q Q  LR+L  +  D   +      +   PD
Sbjct: 2665 AAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2724

Query: 1004 --RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQ 1061
                Q +   ++++E++  ++Q    +A   L +   A + EE  +A+     + ++K  
Sbjct: 2725 AMNQQLETAQKMKQEIQQEKKQIKVAQA---LCEDLSALVKEEYLKAELSRQLEGILKSF 2781

Query: 1062 NDPQLEAE--YQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLK 1119
             D + +AE   Q LQ       Q ++   +  ++L  K +   K   ++     ++ ++K
Sbjct: 2782 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2841

Query: 1120 VEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVR 1179
              KD +  + ++  +  YE   A       E   LL K    E    K  +Q ++  I  
Sbjct: 2842 DHKDFS--KTLTAQSHMYEKTIA-------EGENLLLKTQGSE----KAALQLQLNTI-- 2886

Query: 1180 PDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYK 1239
               K   +  N +++  E+E K + + E+   Y+ ++E L    P ++  +   E IK+ 
Sbjct: 2887 ---KTNWDTFNKQVK--ERENKLKESLEKALKYKEQVETL---WPWIDKCQNNLEEIKFC 2938

Query: 1240 TDPEMEK----ELQRLREEIVDKTRLIERCD------LEIYQLKKEIQALKDTKPQVQTK 1289
             DP   +    +L+ L++E+     ++E  +      L + ++ KE+    + K  +Q  
Sbjct: 2939 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV-VTDENKSLIQKV 2997

Query: 1290 EVVQEILQFQE-DPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQI---ARKEEELSR 1345
            ++V E L  ++   +   +      ++S+E K+Q+   +E+    + +   A   + L+ 
Sbjct: 2998 DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTM 3057

Query: 1346 VKERVVQQEVVRYEEEPGLRAEASAFAESIDVE-----LRQIDKLRAELRRLQRRRTE-- 1398
            ++ +    + ++++ +   R       E+ D +     L Q++ +  E   L ++  E  
Sbjct: 3058 LQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 3117

Query: 1399 --LERQLEELERERQARREAEREVQRLQQRLAALEQ--EEAEAREKVTHTQKVVLQQ--- 1451
              LE +L+ +   +   RE   +       L ++     +AE  +K   T K  L++   
Sbjct: 3118 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3177

Query: 1452 ---DPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKL-AALEKAEVKEKVVLSESVQV 1507
                   A +   + L  EE       ++ +LE L ++    L++A+ +E+ V     ++
Sbjct: 3178 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3237

Query: 1508 EKGDTE-QEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566
            E+  ++ +E   L    EE   S+  + +E   +  +L+  +           F +EE  
Sbjct: 3238 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV----------FQKEEIE 3287

Query: 1567 KLQLERQNLQ-LETRRLQSEINMAATE 1592
             LQ ++Q++  L    +QS     +T+
Sbjct: 3288 PLQGKQQDVNWLGQGLIQSAAKSTSTQ 3314



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 170/848 (20%), Positives = 339/848 (39%), Gaps = 150/848 (17%)

Query: 570  GEAFIQALPGSGTTPLLRTRVEDTNRKYEHL----LQLLDLAQEKVDVANRLEKSLQQ-- 623
            G+  IQ+   S +T  L   ++D N +++ L     Q     QE +    R + +L+   
Sbjct: 3300 GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLL 3359

Query: 624  SWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQK---SLLGEVEQNLQAAK 680
            SW ++ T E   NQ    P S+        E   +  ++Q QK    LL + +  ++  K
Sbjct: 3360 SW-MVDTEELVANQK---PPSA--------EFKVVKAQIQEQKLLQRLLDDRKSTVEVIK 3407

Query: 681  QCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHD 740
            +    +A+  +    D  +   ++  L  R+  L  + E R + L+      + FH   +
Sbjct: 3408 REGEKIATTAEP--ADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3465

Query: 741  HVLQFLVSIP----SYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQ 796
             + ++L +I     + EP  T + S++E ++   K L D+I +  + + +  +  Q  + 
Sbjct: 3466 PLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLK- 3523

Query: 797  AVKDYELEAEKLRSLLD------LENGRSSHVSKRARLQSPATKVK---EEEAALAAKFT 847
             V     + + ++S LD      +E    SH S+   LQ      K   E+E  L     
Sbjct: 3524 -VLSSREDKDMVQSKLDFSQVWYIEIQEKSH-SRSELLQQALCNAKIFGEDEVELMNWLN 3581

Query: 848  EVY-AINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPD------SGVE---------- 890
            EV+  +++  +Q+      L +QQ E+ V  E +   + +      +G+E          
Sbjct: 3582 EVHDKLSKLSVQDYSTE-GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3640

Query: 891  ---------------EAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRK 935
                           +  K+  ++ +  E+  QL   + ST EE+ T  ++      V  
Sbjct: 3641 LIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK------VEV 3694

Query: 936  EVLKKVPDPVLEESFQQLQ---RTLAEEQHKNQLLQEEL-EALQLQLRALEQETRDGGQE 991
            E+L      +  E   Q Q   + L +E   N+ L + L E     L  +    R+G ++
Sbjct: 3695 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3754

Query: 992  YVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEK 1051
             V ++  R    R  +D + Q  EE++A           +L  QQ   A   E S   E 
Sbjct: 3755 MVAEDNERY---RLVSDTITQKVEEIDAA----------ILRSQQFDQAADAELSWITE- 3800

Query: 1052 VTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGK 1111
             TEK+++ L  D +LE            QDQ   + + + +F  + L+  +    + +  
Sbjct: 3801 -TEKKLMSL-GDIRLE------------QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3846

Query: 1112 ITVKEVLKVEKDAATEREVSDLTRQYED--EAAKARASQREKTE-LLRKIWALEEENAKV 1168
              +      E+  + ++++  + + Y+   +    R  Q E+ + L+ + W   EE    
Sbjct: 3847 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3906

Query: 1169 VVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQ--- 1225
            + + +      P P  E E       L +Q+ ++R   E +  ++  ++ + + GPQ   
Sbjct: 3907 LTETQSIISQLPAPALEYET------LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3960

Query: 1226 --------VEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQ 1277
                    ++ K V  + +  +   +++K    L E I   T+  ++ D  +  L++ ++
Sbjct: 3961 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 4020

Query: 1278 ALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIA 1337
             L+                   + P    EV  ++ ++SE +   VD+E+ +   E    
Sbjct: 4021 RLR-------------------QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ 4061

Query: 1338 RKEEELSR 1345
            R EE ++R
Sbjct: 4062 RGEEMIAR 4069



 Score = 71.2 bits (173), Expect = 8e-12
 Identities = 264/1303 (20%), Positives = 495/1303 (37%), Gaps = 209/1303 (16%)

Query: 455  TDPEALALADSLGSQYRSVRQKAAGSKRTLQQ-RYEVLKTENPGDASDLQGRQLLAGLDK 513
            T P+ L L+   G    S+++K   +     Q + +V K     D +  Q  Q    +D+
Sbjct: 3954 TGPQLLELSPGEGF---SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 4010

Query: 514  VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573
            +   L+R    I   LR P      V+   E+  + KN++ ++ +++P        GE  
Sbjct: 4011 ILESLER----IVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066

Query: 574  IQALPGSG---TTPLLRTRVEDTNRKYEHLLQLLDLAQEK-VDVANRLEKSLQQSWELLA 629
            I    G+    +   ++ +++     +E++  L++  + K +DV    EK       L+ 
Sbjct: 4067 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4126

Query: 630  THENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASR 689
            T ++         +  R L+  G + + +  + +A +++  E++  LQ        L S 
Sbjct: 4127 TIKD-------TQDFIRDLEDPGIDPSVVKQQQEAAETIREEID-GLQEELDIVINLGSE 4178

Query: 690  FQEHC--PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLV 747
                C  PD    +  + +L   +++L +  + R   L+ A  A   +  G    LQ + 
Sbjct: 4179 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG----LQAVF 4234

Query: 748  SIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEK 807
                    +  S+S + T L+  K  ++E+             S+ YQQ     ++E E+
Sbjct: 4235 DWVDIAGGKLASMSPIGTDLETVKQQIEELKQ---------FKSEAYQQ-----QIEMER 4280

Query: 808  LRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLL 867
            L    +L   + +  S +  +Q P  ++K     L     E   INRQ    LE AL  L
Sbjct: 4281 LNHQAELLLKKVTEESDKHTVQDPLMELK-----LIWDSLEERIINRQ--HKLEGALLAL 4333

Query: 868  RQQPE--------VEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEE 919
             Q           +  T   L   +P  G  +A +I      E  +   L+N+V + Q  
Sbjct: 4334 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI------ELAKHHVLQNDVLAHQST 4387

Query: 920  IWTLRNQGPQ--ESVVRKEVLKKVPDPVLEESFQQLQRTLAE-EQHKNQL---------L 967
            +  +   G    ES   +E         LE   Q+ Q  L + EQ K QL          
Sbjct: 4388 VEAVNKAGNDLIESSAGEEASNL--QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGF 4445

Query: 968  QEELEALQLQLRALEQETRD----GGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQ 1023
              E+E LQ  L   E+        GG     KE L +  +   A E    +EE      Q
Sbjct: 4446 HGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA---KEETYKSLMQ 4502

Query: 1024 KGAR------EAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDH 1077
            KG +      ++    + Q +  L E+    + K+ E++  KL+    L  E+    +D 
Sbjct: 4503 KGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK-TKLEEALNLAMEFHNSLQDF 4561

Query: 1078 -----QRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSD 1132
                 Q +  L       L  L   L +++      E K+   EV    ++   E + + 
Sbjct: 4562 INWLTQAEQTLNVASRPSL-ILDTVLFQID------EHKVFANEV-NSHREQIIELDKTG 4613

Query: 1133 LTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVR-----EIVRPDPKAESE 1187
               +Y         SQ++   L++ +    +   + VVQ  V      +  R   K   E
Sbjct: 4614 THLKY--------FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4665

Query: 1188 VANLRLELVEQERKYRGAE-----------EQLRSYQSELEALRRRGPQVEVKEVTKEVI 1236
              +  +E +E+  K   +E            QL  ++   ++L  +    +    T   +
Sbjct: 4666 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4725

Query: 1237 KYKT-----DPEMEKELQRLRE-------EIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
            K KT     + +++  L  LR+       + V++   +E   L   Q    +QAL D   
Sbjct: 4726 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4785

Query: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
            +V+ +    + +    D      + + +A   E  K+   ++  + S  E I    ++ S
Sbjct: 4786 RVEPQLAEDQPVHGDID-LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS 4844

Query: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
             VK + +Q+   R+E    L          ++  LRQ ++  + +  L     E E+ L 
Sbjct: 4845 WVKVQ-MQELSTRWETVCALSISKQT---RLEAALRQAEEFHSVVHALLEWLAEAEQTLR 4900

Query: 1405 ---ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVT--HTQKVVLQQDPQQAREH 1459
                L  +  A R     + + ++ +  LE++ AE  +  T   T   +   D     +H
Sbjct: 4901 FHGVLPDDEDALRTL---IDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKH 4957

Query: 1460 --ALLRLQLEE-----EQHRRQL------LEGELETLRRKLAALEKAEV----KEKVVLS 1502
               ++R + EE     +QH+++L      L  + E L   LA L+ AE     K+K V+ 
Sbjct: 4958 WITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5017

Query: 1503 ESVQ------VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSK 1556
            + ++       E     +E+ R +  +++ +++ +    + S L++ +  L+   +   +
Sbjct: 5018 QEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKR 5077

Query: 1557 -ELDFLREENHKLQLERQN---------------LQLETRRLQSEINMAATETRDLRNMT 1600
                 L     + Q+E +N               L LE RR   ++N A     +LR   
Sbjct: 5078 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR---KLNDALDRLEELREF- 5133

Query: 1601 VADSGTNHDSRLW----------SLERELDDLKRLSKDKDLEI 1633
                  N D  +W             R +D  +R+ KD+D +I
Sbjct: 5134 -----ANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKI 5171



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 250/1287 (19%), Positives = 495/1287 (38%), Gaps = 203/1287 (15%)

Query: 454  PTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDK 513
            PTD EA+         + +  ++     + L+ +   L  ENP      + +Q+L  +D 
Sbjct: 2499 PTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDS 2558

Query: 514  VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573
               +L++                    D  ++ ++  N   +   +E +  +   E E  
Sbjct: 2559 KWQELNQ-----------------LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2601

Query: 574  IQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHEN 633
            +  L      P     + +T R+   +L L + A  K            Q  +L A  + 
Sbjct: 2602 VSVLGPLSIDP----NMLNTQRQQVQIL-LQEFATRK-----------PQYEQLTAAGQG 2645

Query: 634  HLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGE-------VEQNLQAAKQCSSTL 686
             L++    P    ++    ++LAA+    Q   SL G+       ++Q +  + Q  S L
Sbjct: 2646 ILSRPGEDPSLRGIVK---EQLAAVT---QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLL 2699

Query: 687  ASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFL 746
             S   +   DL+ + +    +    + + QQ+E   +  Q  +   +   +    + + L
Sbjct: 2700 RS-LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI-KVAQALCEDL 2757

Query: 747  VSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYE--LE 804
             ++   E  + +   Q+E  LK+ K++  +  +  Q +Q  CA+S Q+QQ  +D++  L+
Sbjct: 2758 SALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLD 2817

Query: 805  AEK---------------LRSLLDLENGRS------SHVSKRARLQSPATKVK---EEEA 840
             +K               L SL+      S      SH+ ++   +     +K    E+A
Sbjct: 2818 TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKA 2877

Query: 841  ALAAKFTEVY----AINRQ-------RLQNLEFALNLLRQ-----------QPEVEVTHE 878
            AL  +   +       N+Q         ++LE AL    Q           Q  +E    
Sbjct: 2878 ALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF 2937

Query: 879  TLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKS------TQEEIWTLRNQGPQESV 932
             L     ++ + +   ++KE+D+       L N   S        +E+ T  N       
Sbjct: 2938 CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDEN------- 2990

Query: 933  VRKEVLKKVPDPVLEESFQQ---LQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGG 989
              K +++KV D V E+   +   L+    + +   ++ +E    LQ     L+     G 
Sbjct: 2991 --KSLIQKV-DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGS 3047

Query: 990  QEYVVKEVLRIEPD-------RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALA 1042
            Q Y  K +  ++         + Q D   +L ++L  +        ++VLL   +V  +A
Sbjct: 3048 QAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL-VVEASDSKGTSDVLL---QVETIA 3103

Query: 1043 EEKSRAQEKVTEK---EVVKLQN----DPQLEAEYQQLQEDHQRQDQLR---------EK 1086
            +E S   ++V EK      KLQ        +   + Q  E     D +          +K
Sbjct: 3104 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3163

Query: 1087 QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDA----ATEREVSDLTRQYED--E 1140
            Q+E +     KL+ L      A    T K +L  E+ +      +R++  L++Q     +
Sbjct: 3164 QKETIKAFLKKLEALMASNDNANK--TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD 3221

Query: 1141 AAKARASQREKT-ELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQE 1199
             A+AR  Q E T + L + ++  +E + ++ + +  E  +     E+E  N +L + +  
Sbjct: 3222 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3281

Query: 1200 RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKT 1259
            +K     E L+  Q ++  L +   Q   K  + + +++  D ++    + L +++  + 
Sbjct: 3282 QKEE--IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD-DVNARWKTLNKKVAQRA 3338

Query: 1260 RLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQ 1319
              ++   L   + +  +++L      V T+E+V      Q+ P  + +V   +    +EQ
Sbjct: 3339 AQLQEALLHCGRFQDALESLLSW--MVDTEELVAN----QKPPSAEFKVVKAQI---QEQ 3389

Query: 1320 KKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVEL 1379
            K    L  +R S  E I R+ E+++   E   + ++                       L
Sbjct: 3390 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKI-----------------------L 3426

Query: 1380 RQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEARE 1439
            +Q+  L +    L  +     RQLE +    Q   E    ++ L + L  +E+       
Sbjct: 3427 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET---LEPLNEWLTTIEKRLVNCEP 3483

Query: 1440 KVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKV 1499
              T   K+    + Q A+  AL    +   +H  Q +    ++L+   +  +K  V+ K+
Sbjct: 3484 IGTQASKL----EEQIAQHKALEDDIINHNKHLHQAVSIG-QSLKVLSSREDKDMVQSKL 3538

Query: 1500 VLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVS-RLEARLSELEFHNSKSSKEL 1558
              S+   +E     QE    +S L +++    ++  E    L   L+E+    SK S + 
Sbjct: 3539 DFSQVWYIE----IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ- 3593

Query: 1559 DFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERE 1618
            D+  E   K Q E + LQ +    +  ++ A     +L   T  D       +L +++  
Sbjct: 3594 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKAR 3653

Query: 1619 LDDLKRLSKD--KDLE-IDELQKRLGS 1642
              D+ +LS D  K LE   +L +RL S
Sbjct: 3654 YKDITKLSTDVAKTLEQALQLARRLHS 3680



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 211/1170 (18%), Positives = 466/1170 (39%), Gaps = 171/1170 (14%)

Query: 585  LLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPES 644
            +++ ++E    +Y+      D+ +   DVA  LE++LQ +  L +THE      D V   
Sbjct: 3642 IIQDKLEAIKARYK------DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3695

Query: 645  SRVLDS---KGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQ- 700
                ++   KG+E    A + Q +   L +  +N +A     + ++S   E  P   R+ 
Sbjct: 3696 LLSYETQVLKGEE----ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG 3751

Query: 701  -EAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQF-------LVSIPSY 752
             E  V +  +R+  +   + ++ + + +A    + F +  D  L +       L+S+   
Sbjct: 3752 LEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDI 3811

Query: 753  EPQETDSLSQMET------KLKNQKNLLDEIASREQEVQKICANSQ------QYQQAVKD 800
              ++  + +Q++       ++   K+++D++     ++   C+  +      +  + +K+
Sbjct: 3812 RLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3871

Query: 801  Y----ELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQR 856
            Y    ++ +E+   L   ++  +        L    T+ +   + L A   E   + +Q+
Sbjct: 3872 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3931

Query: 857  LQNLEFALNLLRQQPEVEVTHET---LQRNRPDSG--VEEAW----KIRKELDEETERRR 907
             ++ +    +   +P ++  ++T   L    P  G  ++E +     +  ++ E+ ++R 
Sbjct: 3932 EEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRA 3991

Query: 908  QLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLL 967
               +E  S   +     +Q   ES+ R  +++++  P    S       + E+  +N+ +
Sbjct: 3992 VALDEAISQSTQFHDKIDQ-ILESLER--IVERLRQP---PSISAEVEKIKEQISENKNV 4045

Query: 968  QEELEALQ-----LQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRR 1022
              ++E LQ     L+ R  E   R GG +    + +  +  + + D+++ + E +  L  
Sbjct: 4046 SVDMEKLQPLYETLKQRGEEMIARSGGTD----KDISAKAVQDKLDQMVFIWENIHTLVE 4101

Query: 1023 QKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQ 1082
            ++ A+  +V+ L ++     +  S        ++ ++   DP ++          ++Q +
Sbjct: 4102 EREAKLLDVMELAEKF--WCDHMSLIVTIKDTQDFIRDLEDPGIDPSVV------KQQQE 4153

Query: 1083 LREKQEEELSFLQDKLK---RLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYED 1139
              E   EE+  LQ++L     L  E   A G          E D    ++  D      D
Sbjct: 4154 AAETIREEIDGLQEELDIVINLGSELIAACG----------EPDKPIVKKSIDELNSAWD 4203

Query: 1140 EAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLR-----LE 1194
               KA   + +K E        E   A V  Q+ ++ +      A  ++A++      LE
Sbjct: 4204 SLNKAWKDRIDKLE--------EAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4255

Query: 1195 LVEQE-RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKT-DPEMEKEL--QR 1250
             V+Q+  + +  + +    Q E+E L  +  ++ +K+VT+E  K+   DP ME +L    
Sbjct: 4256 TVKQQIEELKQFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDS 4314

Query: 1251 LREEIVDKTRLIERCDLEIYQLKKEIQ-----------ALKDTKPQVQTKEVVQEILQFQ 1299
            L E I+++   +E   L + Q +  +             L + KP     + ++  ++  
Sbjct: 4315 LEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE--IELA 4372

Query: 1300 EDPQTKEEVASLRAKLSEEQKKQVDLERERASQE-EQIARKEEELSRVKERVVQQEVVRY 1358
            +    + +V + ++ +    K   DL    A +E   +  K E L++  + V+++   R 
Sbjct: 4373 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4432

Query: 1359 EEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAER 1418
            ++              +D  LRQ      E+  LQ+  T+ ER L   +        A+ 
Sbjct: 4433 QQ--------------LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKE 4478

Query: 1419 EVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEG 1478
            ++    +  AA E +E         T K ++Q+  Q      L R     E +    ++ 
Sbjct: 4479 QLNVHMEVCAAFEAKE--------ETYKSLMQKGQQM-----LARCPKSAETN----IDQ 4521

Query: 1479 ELETLRRKLAALE------KAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRE 1532
            ++  L+ K  ++E      K +++E + L+        D    + + + +L   SR    
Sbjct: 4522 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4581

Query: 1533 LDVEVSRLEAR---LSELEFHN------SKSSKELDFLREENHKLQLERQNLQLETRRLQ 1583
            LD  + +++      +E+  H        K+   L +  ++   + +  +NL +  +   
Sbjct: 4582 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLI--KNLLISVQSRW 4639

Query: 1584 SEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEI----DELQKR 1639
             ++     E    R++  A          WS   E  +    S D +LEI    D+++ +
Sbjct: 4640 EKVVQRLVERG--RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ 4697

Query: 1640 LGSVAVKREQRENHLRRSIVVIHPDTGREL 1669
            L     K  Q+    + S+      TGR L
Sbjct: 4698 LAQ--HKEFQKSLGAKHSVYDTTNRTGRSL 4725



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 196/1134 (17%), Positives = 447/1134 (39%), Gaps = 143/1134 (12%)

Query: 599  HLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAM 658
            H    L  +++K+ + + L++ L++        E+ L Q +   E+   L++   ++  +
Sbjct: 1857 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELEN---LEAGADDINGL 1913

Query: 659  ACELQAQKSLLGEVEQN--------------LQAAKQCSSTLASRFQEHCPDLERQEAEV 704
              +L+ QKS   +V  +              L+AAK CS     +        E Q    
Sbjct: 1914 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1973

Query: 705  HKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQ-- 762
            H    RF +L  +      +L+     Y+H+    D     L  + + E   +  LS+  
Sbjct: 1974 HAT-DRFRSLYSKCNVLGNNLKDLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPI 2029

Query: 763  ------METKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLEN 816
                  ++ +L+  K L  +I+S++  V+K+   ++    A          ++  LD   
Sbjct: 2030 AVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIV 2089

Query: 817  GRSSHVSKRA-----RLQSPATKVKEEEAAL------------AAKFTEVYAINRQRLQ- 858
            GR   +SK       +LQ   T+    +  L            + K      +N   LQ 
Sbjct: 2090 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQD 2149

Query: 859  ----NLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVK 914
                N+    ++  +Q  +   +E +++    +    A  ++ ++ + + R  +  ++ K
Sbjct: 2150 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2209

Query: 915  STQEEIWTLRN------------QGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE-Q 961
             T  ++  L+             Q   E+  +      VP   + E  Q +Q + +E  +
Sbjct: 2210 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2269

Query: 962  HKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPD-RAQADEVLQLREELEAL 1020
            HK     + LE L   L+ +        +  V+++   +    +   D + + +E + + 
Sbjct: 2270 HK-----KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC 2324

Query: 1021 RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVK-LQNDPQLEAEYQQLQEDHQR 1079
            + Q  A +  V  L+  +    ++    Q     +++ K L++  +L+ ++     + Q+
Sbjct: 2325 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2384

Query: 1080 QDQLREKQEEELSFLQDKLKRLEKERA-----MAEGKITVKEVLKVEKDAAT-EREVSDL 1133
             +         +S +    K +   ++       EG  T  E     K   + +++++D+
Sbjct: 2385 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2444

Query: 1134 TRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRL 1193
            +  YED     +    E    L K+   +EE++   + + ++++ +   K +   A    
Sbjct: 2445 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS--AMMQWLQKMNKTATKWQQTPAPTDT 2502

Query: 1194 ELVE-QERKYRGAEEQLRSYQSELEALRRRGPQ-VEVKEVTKEVIKYKTD-PEMEKELQR 1250
            E V+ Q  + +  E +L+   ++++ L+ +  + +E    T E  ++K    E++ + Q 
Sbjct: 2503 EAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQE 2562

Query: 1251 LREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDP-QTKEEVA 1309
            L +  +D+ + +E     + Q +     LK     V+ + +V  +     DP     +  
Sbjct: 2563 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQW--LVEKELMVSVLGPLSIDPNMLNTQRQ 2620

Query: 1310 SLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEAS 1369
             ++  L E   ++   E+  A+ +  ++R  E+ S ++  V +Q     ++   L  + S
Sbjct: 2621 QVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPS-LRGIVKEQLAAVTQKWDSLTGQLS 2679

Query: 1370 AFAESIDVELRQIDKLRAELRRLQRRRTELERQL--------------EELERERQARRE 1415
               + ID  + +  + ++ LR L  + ++L+ +L              ++LE  ++ ++E
Sbjct: 2680 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2739

Query: 1416 AERE------VQRLQQRLAALEQE---------------------EAEAREKVTHTQKVV 1448
             ++E       Q L + L+AL +E                     E +A   V H Q   
Sbjct: 2740 IQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSAC 2799

Query: 1449 L--QQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQ 1506
                Q  Q +R+        +EEQ++   +  +L+ L    + ++  +   K + ++S  
Sbjct: 2800 ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLE---SLIKDHKDFSKTLTAQSHM 2856

Query: 1507 VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566
             EK   E E   LK+   E++  + +L+   +  +    +++   +K  + L+  +   +
Sbjct: 2857 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE--KALKY 2914

Query: 1567 KLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELD 1620
            K Q+E          L   I+       +++       G N  ++L SL++E+D
Sbjct: 2915 KEQVE---------TLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMD 2959



 Score = 35.4 bits (80), Expect = 0.49
 Identities = 67/320 (20%), Positives = 133/320 (41%), Gaps = 57/320 (17%)

Query: 26   ELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVL 85
            +L E +E+ +K+ D  E  I +   K+++ LA+ +E           QK L ++  +Y  
Sbjct: 4669 KLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKE----------FQKSLGAKHSVY-- 4715

Query: 86   EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKE-------------- 131
              D          +   +A+D  +L + ++ LR K   I   +V+               
Sbjct: 4716 --DTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4773

Query: 132  ---VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNE-------VKAIGPH 181
               +   ++W   VE +L +  +Q    D+ LV + ++ H  F  E       V+A+   
Sbjct: 4774 TDALQALIDWLYRVEPQLAE--DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4831

Query: 182  LAK--DGDKEQNS-------ELRAKYQKLLAASQARQQHLSSL----QDYMQRCTNELYW 228
              +  +G ++ +S       EL  +++ + A S ++Q  L +     +++       L W
Sbjct: 4832 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4891

Query: 229  LDQQAKG-RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPG 287
            L +  +  R      D      +   Q++ F+ + LE K   +NK  + GD +LA  HP 
Sbjct: 4892 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKK-LEEKRAELNKATTMGDTVLAICHPD 4950

Query: 288  R-NSIEAHMEAVHADWKEYL 306
               +I+  +  + A ++E L
Sbjct: 4951 SITTIKHWITIIRARFEEVL 4970



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 70/347 (20%), Positives = 138/347 (39%), Gaps = 43/347 (12%)

Query: 110  LKERVTNLRGKHKQIYRLAVKE----VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV 165
            L+ER+ N + K +    LA+ +    +D  + W    E  L +   +  G D   ++ ++
Sbjct: 4315 LEERIINRQHKLEGAL-LALGQFQHALDELLAWLTHTEGLLSE--QKPVGGDPKAIEIEL 4371

Query: 166  EEHNIFHNEVKA----------IGPHLAKDGDKEQNSELRAK-------YQKLLAASQAR 208
             +H++  N+V A           G  L +    E+ S L+ K       +Q +L  ++ R
Sbjct: 4372 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQR 4431

Query: 209  QQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLD-YPSRRRQYENF---INRNLE 264
            +Q L       +    E+  L Q      ++  + + L   P   ++  N    +    E
Sbjct: 4432 KQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4491

Query: 265  AKEERINKLHSEGDQLLA-AEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYH 323
            AKEE    L  +G Q+LA        +I+  +  +   W+     L   E   K  E  +
Sbjct: 4492 AKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKL--NERKTKLEEALN 4549

Query: 324  ---QFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQE---KVLDKYEDV 377
               +FH  ++D    L + +  LN    P       ++ +L ++D+ +     ++ + + 
Sbjct: 4550 LAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEVNSHREQ 4605

Query: 378  VQGLQKRGQQVVPLKYRRETPL-KPIPVEALCDFEG-EQGLISRGYS 422
            +  L K G  +     +++  L K + +     +E   Q L+ RG S
Sbjct: 4606 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4652



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 12/85 (14%)

Query: 103  IAEDIRQLKER-------VTNLRGKHKQIYRLAVK---EVDPQVNWAALVEEKLDKLNNQ 152
            I +DI  LKE+       +   + K ++   LA++    +   +NW    E+ L+  +  
Sbjct: 4519 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4578

Query: 153  SFGTDLPLVDHQVEEHNIFHNEVKA 177
            S   D  L   Q++EH +F NEV +
Sbjct: 4579 SLILDTVLF--QIDEHKVFANEVNS 4601


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  311 bits (798), Expect = 3e-84
 Identities = 356/1658 (21%), Positives = 728/1658 (43%), Gaps = 226/1658 (13%)

Query: 129  VKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHL--AKDG 186
            +K V   +NW   V+E   +L+   +G+DLP V+  +E H   H  ++     L  AK  
Sbjct: 783  MKFVQDLLNW---VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 839

Query: 187  DKEQNSELR-----------AKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKG 235
            + +  + L+           ++Y KLL  S+ +++HL +L +++ R TNEL WL+++ + 
Sbjct: 840  EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE 899

Query: 236  RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHM 295
             + YDWS+RN +  +R++ Y   + R L+ KEE I  +    +QLL   HP R +IEA+ 
Sbjct: 900  EVAYDWSERNTNI-ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 958

Query: 296  EAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDR- 354
             A+   W   L L  C E H+K    Y +F  D K+A + LR +   + +KY  D     
Sbjct: 959  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 1018

Query: 355  YQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRR-ETPLK-PIPVEALCDFEG 412
            +++E L++E  ++++ L +Y+  +  L  + + ++ LK R  + PLK  IP++A+CD+  
Sbjct: 1019 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 1078

Query: 413  EQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR 471
             +  I +     L  N+  + W+++   GN+ + P+VCF +PP + EA+ LA+ +  QY+
Sbjct: 1079 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1138

Query: 472  SV----RQKAAGSKRTLQQRYEV-------------LKTENPGD----ASDLQGR----- 505
            +V     +     K  +   Y +             +KT  PG+     S+LQ R     
Sbjct: 1139 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1198

Query: 506  ------QLLAGLDKV------------------ASDLDRQEKAITGI------------- 528
                  Q+ +G D                    +++ + QE+++  +             
Sbjct: 1199 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1258

Query: 529  ---------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579
                     +R PLE+   + +S  R  + + +  EL R++ +    T + E F      
Sbjct: 1259 NCEDRLIRQIRTPLERD-DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA 1317

Query: 580  SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDD 639
            S + P LR+ +    +    +  +     +K+   N + K+ Q +  L+  +E  L +++
Sbjct: 1318 SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEE 1377

Query: 640  TVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLER 699
             V      +++    L     E+  ++ +   +E  LQ AK  S  +   ++E   D + 
Sbjct: 1378 AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDW 1437

Query: 700  QEAEVHKLGQRFNNLRQQVERRAQSLQ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755
             + +  +L +R+ N+  Q++ R + L+    S K   + +H   D + Q   +    +  
Sbjct: 1438 HKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 1497

Query: 756  ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815
            + ++   + T+L  QK L+ EI  ++ ++ +    ++QY   VKDYEL+    R+++D  
Sbjct: 1498 QPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-- 1555

Query: 816  NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875
              +     KR R+QS A  + +E   L  ++T +  +     Q ++FA + L++  E E 
Sbjct: 1556 -SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL---MTQYIKFAGDSLKRLEEEEK 1611

Query: 876  THETLQRNRPDSGVE-EAW--KIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESV 932
            + E  ++   +   E + W   I K L +  +  +   ++ K + EEI T + Q      
Sbjct: 1612 SLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQ------ 1665

Query: 933  VRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEY 992
                         L E+ Q +Q  LA  +H +++  EE   L+ Q++ L++         
Sbjct: 1666 -------------LSEALQTIQLFLA--KHGDKMTDEERNELEKQVKTLQE-----SYNL 1705

Query: 993  VVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKV 1052
            +  E L+ +   +Q    +++ E++ A R+Q+          ++++  + +  ++ + ++
Sbjct: 1706 LFSESLK-QLQESQTSGDVKVEEKIVAERQQE---------YKEKLQGICDLLTQTENRL 1755

Query: 1053 TEKEVVKLQNDPQLE-AEYQQLQEDHQRQDQ-----LREKQEEELSFLQDKLKRLEKE-R 1105
               +   +  D  +E  +YQ  QE+ Q+  Q     L E  +   +FL++  ++L +E +
Sbjct: 1756 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1815

Query: 1106 AMAEGKITVKEV------LKVEKD-AATEREVSDLTRQYEDEAAKARASQREKTELLRKI 1158
            A+ E K+   ++      LK E+     ++ V+   ++  ++ A  +  +  KT++   +
Sbjct: 1816 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1875

Query: 1159 -WA----LEEENA----KVVVQEKVREIVRPDPKA---ESEVANLRLELVEQERKYRGAE 1206
             W      + E A    K V+++        D K+   E +  N  L   + + +    +
Sbjct: 1876 DWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ 1935

Query: 1207 EQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCD 1266
            E L     +++A   +   +  +     +        +EK+ Q L  E  +K +     +
Sbjct: 1936 ENLNQQYQKVKAQHEK---IISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----N 1988

Query: 1267 LEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQED--------PQTKEEVASLRAKLSEE 1318
            ++  ++  E    +  K    T  + +E+ +F  D         Q+++E+ +L A   + 
Sbjct: 1989 MKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDI 2048

Query: 1319 QKKQVDLERERASQEEQIARKEE-ELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDV 1377
                  L+R+++  E+ I+ K +     +    V +      +  G + + SA    +  
Sbjct: 2049 NGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQ- 2107

Query: 1378 ELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEA 1437
              R++D      R L  +   L   L++L  + Q   +A   +      LA L+  EA A
Sbjct: 2108 --RKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL------LAGLQACEATA 2159

Query: 1438 REKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKE 1497
             + ++    V    DP+       L+ QLEE     + L+G++ +   +  A+EK +   
Sbjct: 2160 SKHLSEPIAV----DPKN------LQRQLEE----TKALQGQISS---QQVAVEKLKKTA 2202

Query: 1498 KVVLSE--SVQVEKGDTEQEIQRLKSSLEEESRSKRE----LDVEVSR---LEARLSEL- 1547
            +V+L    S+   K D ++ +  +    E+ S+S  E    L + ++R   ++  L E+ 
Sbjct: 2203 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2262

Query: 1548 -EFHNSKSS-KELDFLREENHKLQ-LERQNLQLE--TRRLQSEINMAATETRDLRNMTVA 1602
                N +SS KE   +   +  LQ +  +N+ LE      QS IN    + +     T  
Sbjct: 2263 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2322

Query: 1603 DSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRL 1640
             + ++  +++  L     +     K+   +++EL+ ++
Sbjct: 2323 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2360



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 326/1767 (18%), Positives = 699/1767 (39%), Gaps = 272/1767 (15%)

Query: 16   TVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKV 75
            TV+ +   +K+  EL + +Q +A  + + + +TE  ++ +  +L +    E + +  QK+
Sbjct: 1768 TVELKKYQSKQ-EELQKDMQGSAQALAEVVKNTENFLKENGEKLSQ----EDKALIEQKL 1822

Query: 76   LDSEKLLYVL---------EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRG------- 119
             +++     L         E D  +   +K     + A  ++QL+E  T +         
Sbjct: 1823 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA--VKQLEESKTKIENLLDWLSN 1880

Query: 120  ----------KHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV---- 165
                      KHKQ+              +A+ EE  D++N     TD   VD QV    
Sbjct: 1881 VDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEE--DEVNGNLLETD---VDGQVGTTQ 1935

Query: 166  EEHNIFHNEVKA-----IGPHLA-----------------------KDGDKEQNSELRAK 197
            E  N  + +VKA     I  H A                       K+  ++   EL+  
Sbjct: 1936 ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVH 1995

Query: 198  YQKLLAASQARQQHLSSLQDYMQRC----TNELYWLDQQAKGRMQYDWSDRNLDYPSRRR 253
            Y+  LA S+ + +   SLQ+ +++     T   +WL Q  +     +    +++    + 
Sbjct: 1996 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 2055

Query: 254  QYENFINRNLEAKEERINKLHSEGDQLLAAEHP--GRNSIEAHMEAVHADWKEYLNLLI- 310
            + +   + ++ + +  +  +   G+++L A      R+  +    A H + +  L+    
Sbjct: 2056 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 2115

Query: 311  --------CEE--SHLKYMEDYHQFHEDVK-----DAQELLRKVDSDLNQKYGPDFKD-R 354
                    C    ++LK + D +Q +ED         Q         L++    D K+ +
Sbjct: 2116 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 2175

Query: 355  YQIE---LLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPI-----PVEA 406
             Q+E    L  ++  Q+  ++K +   + L      ++P K   +  L  I      +  
Sbjct: 2176 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2235

Query: 407  LCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSL 466
              +   E+  I+   S ++Q    E  + M +  + L          P +  AL     +
Sbjct: 2236 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQV----PLNSTAL---QDI 2288

Query: 467  GSQYRSVRQKAAGSKRTLQQRYEVLK----TENPGDASDLQGRQLLAGLDKVASDLDRQE 522
             S+   + Q  AG + ++    E +K    T +P  AS LQ +  +  L    S+   + 
Sbjct: 2289 ISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAK--MKDLSARFSEASHKH 2346

Query: 523  KAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGT 582
            K          E    +++   + +  +N++ +L      KT++  E +     +PG   
Sbjct: 2347 K----------ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVD-----VPGKDV 2391

Query: 583  TPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQ----- 637
            T L +   E T+   EH   L  L     ++++     L     L+    N+L++     
Sbjct: 2392 TELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH---GLPSDKALVLEKTNNLSKKFKEM 2448

Query: 638  DDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVE------------QNLQAAKQCSST 685
            +DT+ E    + S  ++L A    +++ KS + E              ++L  + + +  
Sbjct: 2449 EDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2508

Query: 686  LASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAA------------YE 733
            L  ++    P++++    V+  G    NL   V   A+++ + K+              E
Sbjct: 2509 LQEKWSLKTPEIQK----VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2564

Query: 734  HF--HRGHDHVLQFLVSIP-SYEPQET---DSLSQMETKLKNQKNLLDEIASREQEVQKI 787
             F  ++G   + + +  I   YE       D ++++ TKL   +   +E ++  Q +QK+
Sbjct: 2565 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKM 2624

Query: 788  CANSQQYQQAVKDYELEAEK--LRSLLDLENGRSSHVSKRARLQSPATKVKEE--EAALA 843
               + ++QQ     + EA K  +      E     +V+K   L+   T++ EE  +   A
Sbjct: 2625 NKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2684

Query: 844  AKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEET 903
             ++ ++      + Q L   L + RQQ   E ++   Q    ++ +++ W + KEL    
Sbjct: 2685 PRWKQMLTEIDSKWQELN-QLTIDRQQKLEESSNNLTQFQTVEAQLKQ-WLVEKELMVSV 2742

Query: 904  ERRRQLENEVKSTQ--------EEIWTLRNQGPQESVVRKEVLKKV-PDPVLEESFQQLQ 954
                 ++  + +TQ        +E  T + Q  Q +   + +L +   DP L    ++  
Sbjct: 2743 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2802

Query: 955  RTLAEE---------QHKNQLLQEELEALQLQ--LRALEQETRDGGQEYVVKEVLRIEPD 1003
              + ++            + + Q  +++ Q Q  LR+L  +  D   +      +   PD
Sbjct: 2803 AAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2862

Query: 1004 --RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQ 1061
                Q +   ++++E++  ++Q    +A   L +   A + EE  +A+     + ++K  
Sbjct: 2863 AMNQQLETAQKMKQEIQQEKKQIKVAQA---LCEDLSALVKEEYLKAELSRQLEGILKSF 2919

Query: 1062 NDPQLEAE--YQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLK 1119
             D + +AE   Q LQ       Q ++   +  ++L  K +   K   ++     ++ ++K
Sbjct: 2920 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2979

Query: 1120 VEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVR 1179
              KD +  + ++  +  YE   A       E   LL K    E    K  +Q ++  I  
Sbjct: 2980 DHKDFS--KTLTAQSHMYEKTIA-------EGENLLLKTQGSE----KAALQLQLNTI-- 3024

Query: 1180 PDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYK 1239
               K   +  N +++  E+E K + + E+   Y+ ++E L    P ++  +   E IK+ 
Sbjct: 3025 ---KTNWDTFNKQVK--ERENKLKESLEKALKYKEQVETL---WPWIDKCQNNLEEIKFC 3076

Query: 1240 TDPEMEK----ELQRLREEIVDKTRLIERCD------LEIYQLKKEIQALKDTKPQVQTK 1289
             DP   +    +L+ L++E+     ++E  +      L + ++ KE+    + K  +Q  
Sbjct: 3077 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV-VTDENKSLIQKV 3135

Query: 1290 EVVQEILQFQE-DPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQI---ARKEEELSR 1345
            ++V E L  ++   +   +      ++S+E K+Q+   +E+    + +   A   + L+ 
Sbjct: 3136 DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTM 3195

Query: 1346 VKERVVQQEVVRYEEEPGLRAEASAFAESIDVE-----LRQIDKLRAELRRLQRRRTE-- 1398
            ++ +    + ++++ +   R       E+ D +     L Q++ +  E   L ++  E  
Sbjct: 3196 LQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 3255

Query: 1399 --LERQLEELERERQARREAEREVQRLQQRLAALEQ--EEAEAREKVTHTQKVVLQQ--- 1451
              LE +L+ +   +   RE   +       L ++     +AE  +K   T K  L++   
Sbjct: 3256 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3315

Query: 1452 ---DPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKL-AALEKAEVKEKVVLSESVQV 1507
                   A +   + L  EE       ++ +LE L ++    L++A+ +E+ V     ++
Sbjct: 3316 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3375

Query: 1508 EKGDTE-QEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566
            E+  ++ +E   L    EE   S+  + +E   +  +L+  +           F +EE  
Sbjct: 3376 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV----------FQKEEIE 3425

Query: 1567 KLQLERQNLQ-LETRRLQSEINMAATE 1592
             LQ ++Q++  L    +QS     +T+
Sbjct: 3426 PLQGKQQDVNWLGQGLIQSAAKSTSTQ 3452



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 170/848 (20%), Positives = 339/848 (39%), Gaps = 150/848 (17%)

Query: 570  GEAFIQALPGSGTTPLLRTRVEDTNRKYEHL----LQLLDLAQEKVDVANRLEKSLQQ-- 623
            G+  IQ+   S +T  L   ++D N +++ L     Q     QE +    R + +L+   
Sbjct: 3438 GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLL 3497

Query: 624  SWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQK---SLLGEVEQNLQAAK 680
            SW ++ T E   NQ    P S+        E   +  ++Q QK    LL + +  ++  K
Sbjct: 3498 SW-MVDTEELVANQK---PPSA--------EFKVVKAQIQEQKLLQRLLDDRKSTVEVIK 3545

Query: 681  QCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHD 740
            +    +A+  +    D  +   ++  L  R+  L  + E R + L+      + FH   +
Sbjct: 3546 REGEKIATTAEP--ADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3603

Query: 741  HVLQFLVSIP----SYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQ 796
             + ++L +I     + EP  T + S++E ++   K L D+I +  + + +  +  Q  + 
Sbjct: 3604 PLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLK- 3661

Query: 797  AVKDYELEAEKLRSLLD------LENGRSSHVSKRARLQSPATKVK---EEEAALAAKFT 847
             V     + + ++S LD      +E    SH S+   LQ      K   E+E  L     
Sbjct: 3662 -VLSSREDKDMVQSKLDFSQVWYIEIQEKSH-SRSELLQQALCNAKIFGEDEVELMNWLN 3719

Query: 848  EVY-AINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPD------SGVE---------- 890
            EV+  +++  +Q+      L +QQ E+ V  E +   + +      +G+E          
Sbjct: 3720 EVHDKLSKLSVQDYSTE-GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3778

Query: 891  ---------------EAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRK 935
                           +  K+  ++ +  E+  QL   + ST EE+ T  ++      V  
Sbjct: 3779 LIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK------VEV 3832

Query: 936  EVLKKVPDPVLEESFQQLQ---RTLAEEQHKNQLLQEEL-EALQLQLRALEQETRDGGQE 991
            E+L      +  E   Q Q   + L +E   N+ L + L E     L  +    R+G ++
Sbjct: 3833 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3892

Query: 992  YVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEK 1051
             V ++  R    R  +D + Q  EE++A           +L  QQ   A   E S   E 
Sbjct: 3893 MVAEDNERY---RLVSDTITQKVEEIDAA----------ILRSQQFDQAADAELSWITE- 3938

Query: 1052 VTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGK 1111
             TEK+++ L  D +LE            QDQ   + + + +F  + L+  +    + +  
Sbjct: 3939 -TEKKLMSL-GDIRLE------------QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3984

Query: 1112 ITVKEVLKVEKDAATEREVSDLTRQYED--EAAKARASQREKTE-LLRKIWALEEENAKV 1168
              +      E+  + ++++  + + Y+   +    R  Q E+ + L+ + W   EE    
Sbjct: 3985 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 4044

Query: 1169 VVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQ--- 1225
            + + +      P P  E E       L +Q+ ++R   E +  ++  ++ + + GPQ   
Sbjct: 4045 LTETQSIISQLPAPALEYET------LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 4098

Query: 1226 --------VEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQ 1277
                    ++ K V  + +  +   +++K    L E I   T+  ++ D  +  L++ ++
Sbjct: 4099 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 4158

Query: 1278 ALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIA 1337
             L+                   + P    EV  ++ ++SE +   VD+E+ +   E    
Sbjct: 4159 RLR-------------------QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ 4199

Query: 1338 RKEEELSR 1345
            R EE ++R
Sbjct: 4200 RGEEMIAR 4207



 Score = 71.2 bits (173), Expect = 8e-12
 Identities = 264/1303 (20%), Positives = 495/1303 (37%), Gaps = 209/1303 (16%)

Query: 455  TDPEALALADSLGSQYRSVRQKAAGSKRTLQQ-RYEVLKTENPGDASDLQGRQLLAGLDK 513
            T P+ L L+   G    S+++K   +     Q + +V K     D +  Q  Q    +D+
Sbjct: 4092 TGPQLLELSPGEGF---SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 4148

Query: 514  VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573
            +   L+R    I   LR P      V+   E+  + KN++ ++ +++P        GE  
Sbjct: 4149 ILESLER----IVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4204

Query: 574  IQALPGSG---TTPLLRTRVEDTNRKYEHLLQLLDLAQEK-VDVANRLEKSLQQSWELLA 629
            I    G+    +   ++ +++     +E++  L++  + K +DV    EK       L+ 
Sbjct: 4205 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4264

Query: 630  THENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASR 689
            T ++         +  R L+  G + + +  + +A +++  E++  LQ        L S 
Sbjct: 4265 TIKD-------TQDFIRDLEDPGIDPSVVKQQQEAAETIREEID-GLQEELDIVINLGSE 4316

Query: 690  FQEHC--PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLV 747
                C  PD    +  + +L   +++L +  + R   L+ A  A   +  G    LQ + 
Sbjct: 4317 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG----LQAVF 4372

Query: 748  SIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEK 807
                    +  S+S + T L+  K  ++E+             S+ YQQ     ++E E+
Sbjct: 4373 DWVDIAGGKLASMSPIGTDLETVKQQIEELKQ---------FKSEAYQQ-----QIEMER 4418

Query: 808  LRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLL 867
            L    +L   + +  S +  +Q P  ++K     L     E   INRQ    LE AL  L
Sbjct: 4419 LNHQAELLLKKVTEESDKHTVQDPLMELK-----LIWDSLEERIINRQ--HKLEGALLAL 4471

Query: 868  RQQPE--------VEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEE 919
             Q           +  T   L   +P  G  +A +I      E  +   L+N+V + Q  
Sbjct: 4472 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI------ELAKHHVLQNDVLAHQST 4525

Query: 920  IWTLRNQGPQ--ESVVRKEVLKKVPDPVLEESFQQLQRTLAE-EQHKNQL---------L 967
            +  +   G    ES   +E         LE   Q+ Q  L + EQ K QL          
Sbjct: 4526 VEAVNKAGNDLIESSAGEEASNL--QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGF 4583

Query: 968  QEELEALQLQLRALEQETRD----GGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQ 1023
              E+E LQ  L   E+        GG     KE L +  +   A E    +EE      Q
Sbjct: 4584 HGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA---KEETYKSLMQ 4640

Query: 1024 KGAR------EAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDH 1077
            KG +      ++    + Q +  L E+    + K+ E++  KL+    L  E+    +D 
Sbjct: 4641 KGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK-TKLEEALNLAMEFHNSLQDF 4699

Query: 1078 -----QRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSD 1132
                 Q +  L       L  L   L +++      E K+   EV    ++   E + + 
Sbjct: 4700 INWLTQAEQTLNVASRPSL-ILDTVLFQID------EHKVFANEV-NSHREQIIELDKTG 4751

Query: 1133 LTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVR-----EIVRPDPKAESE 1187
               +Y         SQ++   L++ +    +   + VVQ  V      +  R   K   E
Sbjct: 4752 THLKY--------FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4803

Query: 1188 VANLRLELVEQERKYRGAE-----------EQLRSYQSELEALRRRGPQVEVKEVTKEVI 1236
              +  +E +E+  K   +E            QL  ++   ++L  +    +    T   +
Sbjct: 4804 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4863

Query: 1237 KYKT-----DPEMEKELQRLRE-------EIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
            K KT     + +++  L  LR+       + V++   +E   L   Q    +QAL D   
Sbjct: 4864 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4923

Query: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
            +V+ +    + +    D      + + +A   E  K+   ++  + S  E I    ++ S
Sbjct: 4924 RVEPQLAEDQPVHGDID-LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS 4982

Query: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
             VK + +Q+   R+E    L          ++  LRQ ++  + +  L     E E+ L 
Sbjct: 4983 WVKVQ-MQELSTRWETVCALSISKQT---RLEAALRQAEEFHSVVHALLEWLAEAEQTLR 5038

Query: 1405 ---ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVT--HTQKVVLQQDPQQAREH 1459
                L  +  A R     + + ++ +  LE++ AE  +  T   T   +   D     +H
Sbjct: 5039 FHGVLPDDEDALRTL---IDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKH 5095

Query: 1460 --ALLRLQLEE-----EQHRRQL------LEGELETLRRKLAALEKAEV----KEKVVLS 1502
               ++R + EE     +QH+++L      L  + E L   LA L+ AE     K+K V+ 
Sbjct: 5096 WITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 5155

Query: 1503 ESVQ------VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSK 1556
            + ++       E     +E+ R +  +++ +++ +    + S L++ +  L+   +   +
Sbjct: 5156 QEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKR 5215

Query: 1557 -ELDFLREENHKLQLERQN---------------LQLETRRLQSEINMAATETRDLRNMT 1600
                 L     + Q+E +N               L LE RR   ++N A     +LR   
Sbjct: 5216 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR---KLNDALDRLEELREF- 5271

Query: 1601 VADSGTNHDSRLW----------SLERELDDLKRLSKDKDLEI 1633
                  N D  +W             R +D  +R+ KD+D +I
Sbjct: 5272 -----ANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKI 5309



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 250/1287 (19%), Positives = 495/1287 (38%), Gaps = 203/1287 (15%)

Query: 454  PTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDK 513
            PTD EA+         + +  ++     + L+ +   L  ENP      + +Q+L  +D 
Sbjct: 2637 PTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDS 2696

Query: 514  VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573
               +L++                    D  ++ ++  N   +   +E +  +   E E  
Sbjct: 2697 KWQELNQ-----------------LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2739

Query: 574  IQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHEN 633
            +  L      P     + +T R+   +L L + A  K            Q  +L A  + 
Sbjct: 2740 VSVLGPLSIDP----NMLNTQRQQVQIL-LQEFATRK-----------PQYEQLTAAGQG 2783

Query: 634  HLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGE-------VEQNLQAAKQCSSTL 686
             L++    P    ++    ++LAA+    Q   SL G+       ++Q +  + Q  S L
Sbjct: 2784 ILSRPGEDPSLRGIVK---EQLAAVT---QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLL 2837

Query: 687  ASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFL 746
             S   +   DL+ + +    +    + + QQ+E   +  Q  +   +   +    + + L
Sbjct: 2838 RS-LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI-KVAQALCEDL 2895

Query: 747  VSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYE--LE 804
             ++   E  + +   Q+E  LK+ K++  +  +  Q +Q  CA+S Q+QQ  +D++  L+
Sbjct: 2896 SALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLD 2955

Query: 805  AEK---------------LRSLLDLENGRS------SHVSKRARLQSPATKVK---EEEA 840
             +K               L SL+      S      SH+ ++   +     +K    E+A
Sbjct: 2956 TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKA 3015

Query: 841  ALAAKFTEVY----AINRQ-------RLQNLEFALNLLRQ-----------QPEVEVTHE 878
            AL  +   +       N+Q         ++LE AL    Q           Q  +E    
Sbjct: 3016 ALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF 3075

Query: 879  TLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKS------TQEEIWTLRNQGPQESV 932
             L     ++ + +   ++KE+D+       L N   S        +E+ T  N       
Sbjct: 3076 CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDEN------- 3128

Query: 933  VRKEVLKKVPDPVLEESFQQ---LQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGG 989
              K +++KV D V E+   +   L+    + +   ++ +E    LQ     L+     G 
Sbjct: 3129 --KSLIQKV-DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGS 3185

Query: 990  QEYVVKEVLRIEPD-------RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALA 1042
            Q Y  K +  ++         + Q D   +L ++L  +        ++VLL   +V  +A
Sbjct: 3186 QAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL-VVEASDSKGTSDVLL---QVETIA 3241

Query: 1043 EEKSRAQEKVTEK---EVVKLQN----DPQLEAEYQQLQEDHQRQDQLR---------EK 1086
            +E S   ++V EK      KLQ        +   + Q  E     D +          +K
Sbjct: 3242 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3301

Query: 1087 QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDA----ATEREVSDLTRQYED--E 1140
            Q+E +     KL+ L      A    T K +L  E+ +      +R++  L++Q     +
Sbjct: 3302 QKETIKAFLKKLEALMASNDNANK--TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD 3359

Query: 1141 AAKARASQREKT-ELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQE 1199
             A+AR  Q E T + L + ++  +E + ++ + +  E  +     E+E  N +L + +  
Sbjct: 3360 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3419

Query: 1200 RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKT 1259
            +K     E L+  Q ++  L +   Q   K  + + +++  D ++    + L +++  + 
Sbjct: 3420 QKEE--IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD-DVNARWKTLNKKVAQRA 3476

Query: 1260 RLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQ 1319
              ++   L   + +  +++L      V T+E+V      Q+ P  + +V   +    +EQ
Sbjct: 3477 AQLQEALLHCGRFQDALESLLSW--MVDTEELVAN----QKPPSAEFKVVKAQI---QEQ 3527

Query: 1320 KKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVEL 1379
            K    L  +R S  E I R+ E+++   E   + ++                       L
Sbjct: 3528 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKI-----------------------L 3564

Query: 1380 RQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEARE 1439
            +Q+  L +    L  +     RQLE +    Q   E    ++ L + L  +E+       
Sbjct: 3565 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET---LEPLNEWLTTIEKRLVNCEP 3621

Query: 1440 KVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKV 1499
              T   K+    + Q A+  AL    +   +H  Q +    ++L+   +  +K  V+ K+
Sbjct: 3622 IGTQASKL----EEQIAQHKALEDDIINHNKHLHQAVSIG-QSLKVLSSREDKDMVQSKL 3676

Query: 1500 VLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVS-RLEARLSELEFHNSKSSKEL 1558
              S+   +E     QE    +S L +++    ++  E    L   L+E+    SK S + 
Sbjct: 3677 DFSQVWYIE----IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ- 3731

Query: 1559 DFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERE 1618
            D+  E   K Q E + LQ +    +  ++ A     +L   T  D       +L +++  
Sbjct: 3732 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKAR 3791

Query: 1619 LDDLKRLSKD--KDLE-IDELQKRLGS 1642
              D+ +LS D  K LE   +L +RL S
Sbjct: 3792 YKDITKLSTDVAKTLEQALQLARRLHS 3818



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 211/1170 (18%), Positives = 466/1170 (39%), Gaps = 171/1170 (14%)

Query: 585  LLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPES 644
            +++ ++E    +Y+      D+ +   DVA  LE++LQ +  L +THE      D V   
Sbjct: 3780 IIQDKLEAIKARYK------DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3833

Query: 645  SRVLDS---KGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQ- 700
                ++   KG+E    A + Q +   L +  +N +A     + ++S   E  P   R+ 
Sbjct: 3834 LLSYETQVLKGEE----ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG 3889

Query: 701  -EAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQF-------LVSIPSY 752
             E  V +  +R+  +   + ++ + + +A    + F +  D  L +       L+S+   
Sbjct: 3890 LEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDI 3949

Query: 753  EPQETDSLSQMET------KLKNQKNLLDEIASREQEVQKICANSQ------QYQQAVKD 800
              ++  + +Q++       ++   K+++D++     ++   C+  +      +  + +K+
Sbjct: 3950 RLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 4009

Query: 801  Y----ELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQR 856
            Y    ++ +E+   L   ++  +        L    T+ +   + L A   E   + +Q+
Sbjct: 4010 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 4069

Query: 857  LQNLEFALNLLRQQPEVEVTHET---LQRNRPDSG--VEEAW----KIRKELDEETERRR 907
             ++ +    +   +P ++  ++T   L    P  G  ++E +     +  ++ E+ ++R 
Sbjct: 4070 EEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRA 4129

Query: 908  QLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLL 967
               +E  S   +     +Q   ES+ R  +++++  P    S       + E+  +N+ +
Sbjct: 4130 VALDEAISQSTQFHDKIDQ-ILESLER--IVERLRQP---PSISAEVEKIKEQISENKNV 4183

Query: 968  QEELEALQ-----LQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRR 1022
              ++E LQ     L+ R  E   R GG +    + +  +  + + D+++ + E +  L  
Sbjct: 4184 SVDMEKLQPLYETLKQRGEEMIARSGGTD----KDISAKAVQDKLDQMVFIWENIHTLVE 4239

Query: 1023 QKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQ 1082
            ++ A+  +V+ L ++     +  S        ++ ++   DP ++          ++Q +
Sbjct: 4240 EREAKLLDVMELAEKF--WCDHMSLIVTIKDTQDFIRDLEDPGIDPSVV------KQQQE 4291

Query: 1083 LREKQEEELSFLQDKLK---RLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYED 1139
              E   EE+  LQ++L     L  E   A G          E D    ++  D      D
Sbjct: 4292 AAETIREEIDGLQEELDIVINLGSELIAACG----------EPDKPIVKKSIDELNSAWD 4341

Query: 1140 EAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLR-----LE 1194
               KA   + +K E        E   A V  Q+ ++ +      A  ++A++      LE
Sbjct: 4342 SLNKAWKDRIDKLE--------EAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4393

Query: 1195 LVEQE-RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKT-DPEMEKEL--QR 1250
             V+Q+  + +  + +    Q E+E L  +  ++ +K+VT+E  K+   DP ME +L    
Sbjct: 4394 TVKQQIEELKQFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDS 4452

Query: 1251 LREEIVDKTRLIERCDLEIYQLKKEIQ-----------ALKDTKPQVQTKEVVQEILQFQ 1299
            L E I+++   +E   L + Q +  +             L + KP     + ++  ++  
Sbjct: 4453 LEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE--IELA 4510

Query: 1300 EDPQTKEEVASLRAKLSEEQKKQVDLERERASQE-EQIARKEEELSRVKERVVQQEVVRY 1358
            +    + +V + ++ +    K   DL    A +E   +  K E L++  + V+++   R 
Sbjct: 4511 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4570

Query: 1359 EEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAER 1418
            ++              +D  LRQ      E+  LQ+  T+ ER L   +        A+ 
Sbjct: 4571 QQ--------------LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKE 4616

Query: 1419 EVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEG 1478
            ++    +  AA E +E         T K ++Q+  Q      L R     E +    ++ 
Sbjct: 4617 QLNVHMEVCAAFEAKE--------ETYKSLMQKGQQM-----LARCPKSAETN----IDQ 4659

Query: 1479 ELETLRRKLAALE------KAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRE 1532
            ++  L+ K  ++E      K +++E + L+        D    + + + +L   SR    
Sbjct: 4660 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4719

Query: 1533 LDVEVSRLEAR---LSELEFHN------SKSSKELDFLREENHKLQLERQNLQLETRRLQ 1583
            LD  + +++      +E+  H        K+   L +  ++   + +  +NL +  +   
Sbjct: 4720 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLI--KNLLISVQSRW 4777

Query: 1584 SEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEI----DELQKR 1639
             ++     E    R++  A          WS   E  +    S D +LEI    D+++ +
Sbjct: 4778 EKVVQRLVERG--RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ 4835

Query: 1640 LGSVAVKREQRENHLRRSIVVIHPDTGREL 1669
            L     K  Q+    + S+      TGR L
Sbjct: 4836 LAQ--HKEFQKSLGAKHSVYDTTNRTGRSL 4863



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 196/1134 (17%), Positives = 447/1134 (39%), Gaps = 143/1134 (12%)

Query: 599  HLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAM 658
            H    L  +++K+ + + L++ L++        E+ L Q +   E+   L++   ++  +
Sbjct: 1995 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELEN---LEAGADDINGL 2051

Query: 659  ACELQAQKSLLGEVEQN--------------LQAAKQCSSTLASRFQEHCPDLERQEAEV 704
              +L+ QKS   +V  +              L+AAK CS     +        E Q    
Sbjct: 2052 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 2111

Query: 705  HKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQ-- 762
            H    RF +L  +      +L+     Y+H+    D     L  + + E   +  LS+  
Sbjct: 2112 HAT-DRFRSLYSKCNVLGNNLKDLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPI 2167

Query: 763  ------METKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLEN 816
                  ++ +L+  K L  +I+S++  V+K+   ++    A          ++  LD   
Sbjct: 2168 AVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIV 2227

Query: 817  GRSSHVSKRA-----RLQSPATKVKEEEAAL------------AAKFTEVYAINRQRLQ- 858
            GR   +SK       +LQ   T+    +  L            + K      +N   LQ 
Sbjct: 2228 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQD 2287

Query: 859  ----NLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVK 914
                N+    ++  +Q  +   +E +++    +    A  ++ ++ + + R  +  ++ K
Sbjct: 2288 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2347

Query: 915  STQEEIWTLRN------------QGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE-Q 961
             T  ++  L+             Q   E+  +      VP   + E  Q +Q + +E  +
Sbjct: 2348 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2407

Query: 962  HKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPD-RAQADEVLQLREELEAL 1020
            HK     + LE L   L+ +        +  V+++   +    +   D + + +E + + 
Sbjct: 2408 HK-----KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC 2462

Query: 1021 RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVK-LQNDPQLEAEYQQLQEDHQR 1079
            + Q  A +  V  L+  +    ++    Q     +++ K L++  +L+ ++     + Q+
Sbjct: 2463 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2522

Query: 1080 QDQLREKQEEELSFLQDKLKRLEKERA-----MAEGKITVKEVLKVEKDAAT-EREVSDL 1133
             +         +S +    K +   ++       EG  T  E     K   + +++++D+
Sbjct: 2523 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2582

Query: 1134 TRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRL 1193
            +  YED     +    E    L K+   +EE++   + + ++++ +   K +   A    
Sbjct: 2583 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS--AMMQWLQKMNKTATKWQQTPAPTDT 2640

Query: 1194 ELVE-QERKYRGAEEQLRSYQSELEALRRRGPQ-VEVKEVTKEVIKYKTD-PEMEKELQR 1250
            E V+ Q  + +  E +L+   ++++ L+ +  + +E    T E  ++K    E++ + Q 
Sbjct: 2641 EAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQE 2700

Query: 1251 LREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDP-QTKEEVA 1309
            L +  +D+ + +E     + Q +     LK     V+ + +V  +     DP     +  
Sbjct: 2701 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQW--LVEKELMVSVLGPLSIDPNMLNTQRQ 2758

Query: 1310 SLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEAS 1369
             ++  L E   ++   E+  A+ +  ++R  E+ S ++  V +Q     ++   L  + S
Sbjct: 2759 QVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPS-LRGIVKEQLAAVTQKWDSLTGQLS 2817

Query: 1370 AFAESIDVELRQIDKLRAELRRLQRRRTELERQL--------------EELERERQARRE 1415
               + ID  + +  + ++ LR L  + ++L+ +L              ++LE  ++ ++E
Sbjct: 2818 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2877

Query: 1416 AERE------VQRLQQRLAALEQE---------------------EAEAREKVTHTQKVV 1448
             ++E       Q L + L+AL +E                     E +A   V H Q   
Sbjct: 2878 IQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSAC 2937

Query: 1449 L--QQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQ 1506
                Q  Q +R+        +EEQ++   +  +L+ L    + ++  +   K + ++S  
Sbjct: 2938 ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLE---SLIKDHKDFSKTLTAQSHM 2994

Query: 1507 VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566
             EK   E E   LK+   E++  + +L+   +  +    +++   +K  + L+  +   +
Sbjct: 2995 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE--KALKY 3052

Query: 1567 KLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELD 1620
            K Q+E          L   I+       +++       G N  ++L SL++E+D
Sbjct: 3053 KEQVE---------TLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMD 3097



 Score = 35.4 bits (80), Expect = 0.49
 Identities = 67/320 (20%), Positives = 133/320 (41%), Gaps = 57/320 (17%)

Query: 26   ELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVL 85
            +L E +E+ +K+ D  E  I +   K+++ LA+ +E           QK L ++  +Y  
Sbjct: 4807 KLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKE----------FQKSLGAKHSVY-- 4853

Query: 86   EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKE-------------- 131
              D          +   +A+D  +L + ++ LR K   I   +V+               
Sbjct: 4854 --DTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4911

Query: 132  ---VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNE-------VKAIGPH 181
               +   ++W   VE +L +  +Q    D+ LV + ++ H  F  E       V+A+   
Sbjct: 4912 TDALQALIDWLYRVEPQLAE--DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4969

Query: 182  LAK--DGDKEQNS-------ELRAKYQKLLAASQARQQHLSSL----QDYMQRCTNELYW 228
              +  +G ++ +S       EL  +++ + A S ++Q  L +     +++       L W
Sbjct: 4970 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 5029

Query: 229  LDQQAKG-RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPG 287
            L +  +  R      D      +   Q++ F+ + LE K   +NK  + GD +LA  HP 
Sbjct: 5030 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKK-LEEKRAELNKATTMGDTVLAICHPD 5088

Query: 288  R-NSIEAHMEAVHADWKEYL 306
               +I+  +  + A ++E L
Sbjct: 5089 SITTIKHWITIIRARFEEVL 5108



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 70/347 (20%), Positives = 138/347 (39%), Gaps = 43/347 (12%)

Query: 110  LKERVTNLRGKHKQIYRLAVKE----VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV 165
            L+ER+ N + K +    LA+ +    +D  + W    E  L +   +  G D   ++ ++
Sbjct: 4453 LEERIINRQHKLEGAL-LALGQFQHALDELLAWLTHTEGLLSE--QKPVGGDPKAIEIEL 4509

Query: 166  EEHNIFHNEVKA----------IGPHLAKDGDKEQNSELRAK-------YQKLLAASQAR 208
             +H++  N+V A           G  L +    E+ S L+ K       +Q +L  ++ R
Sbjct: 4510 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQR 4569

Query: 209  QQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLD-YPSRRRQYENF---INRNLE 264
            +Q L       +    E+  L Q      ++  + + L   P   ++  N    +    E
Sbjct: 4570 KQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4629

Query: 265  AKEERINKLHSEGDQLLA-AEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYH 323
            AKEE    L  +G Q+LA        +I+  +  +   W+     L   E   K  E  +
Sbjct: 4630 AKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKL--NERKTKLEEALN 4687

Query: 324  ---QFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQE---KVLDKYEDV 377
               +FH  ++D    L + +  LN    P       ++ +L ++D+ +     ++ + + 
Sbjct: 4688 LAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEVNSHREQ 4743

Query: 378  VQGLQKRGQQVVPLKYRRETPL-KPIPVEALCDFEG-EQGLISRGYS 422
            +  L K G  +     +++  L K + +     +E   Q L+ RG S
Sbjct: 4744 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4790



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 12/85 (14%)

Query: 103  IAEDIRQLKER-------VTNLRGKHKQIYRLAVK---EVDPQVNWAALVEEKLDKLNNQ 152
            I +DI  LKE+       +   + K ++   LA++    +   +NW    E+ L+  +  
Sbjct: 4657 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4716

Query: 153  SFGTDLPLVDHQVEEHNIFHNEVKA 177
            S   D  L   Q++EH +F NEV +
Sbjct: 4717 SLILDTVLF--QIDEHKVFANEVNS 4739


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  311 bits (798), Expect = 3e-84
 Identities = 356/1658 (21%), Positives = 728/1658 (43%), Gaps = 226/1658 (13%)

Query: 129  VKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHL--AKDG 186
            +K V   +NW   V+E   +L+   +G+DLP V+  +E H   H  ++     L  AK  
Sbjct: 605  MKFVQDLLNW---VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 661

Query: 187  DKEQNSELR-----------AKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKG 235
            + +  + L+           ++Y KLL  S+ +++HL +L +++ R TNEL WL+++ + 
Sbjct: 662  EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE 721

Query: 236  RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHM 295
             + YDWS+RN +  +R++ Y   + R L+ KEE I  +    +QLL   HP R +IEA+ 
Sbjct: 722  EVAYDWSERNTNI-ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780

Query: 296  EAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDR- 354
             A+   W   L L  C E H+K    Y +F  D K+A + LR +   + +KY  D     
Sbjct: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840

Query: 355  YQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRR-ETPLK-PIPVEALCDFEG 412
            +++E L++E  ++++ L +Y+  +  L  + + ++ LK R  + PLK  IP++A+CD+  
Sbjct: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900

Query: 413  EQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR 471
             +  I +     L  N+  + W+++   GN+ + P+VCF +PP + EA+ LA+ +  QY+
Sbjct: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960

Query: 472  SV----RQKAAGSKRTLQQRYEV-------------LKTENPGD----ASDLQGR----- 505
            +V     +     K  +   Y +             +KT  PG+     S+LQ R     
Sbjct: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020

Query: 506  ------QLLAGLDKV------------------ASDLDRQEKAITGI------------- 528
                  Q+ +G D                    +++ + QE+++  +             
Sbjct: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080

Query: 529  ---------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579
                     +R PLE+   + +S  R  + + +  EL R++ +    T + E F      
Sbjct: 1081 NCEDRLIRQIRTPLERD-DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA 1139

Query: 580  SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDD 639
            S + P LR+ +    +    +  +     +K+   N + K+ Q +  L+  +E  L +++
Sbjct: 1140 SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEE 1199

Query: 640  TVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLER 699
             V      +++    L     E+  ++ +   +E  LQ AK  S  +   ++E   D + 
Sbjct: 1200 AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDW 1259

Query: 700  QEAEVHKLGQRFNNLRQQVERRAQSLQ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755
             + +  +L +R+ N+  Q++ R + L+    S K   + +H   D + Q   +    +  
Sbjct: 1260 HKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 1319

Query: 756  ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815
            + ++   + T+L  QK L+ EI  ++ ++ +    ++QY   VKDYEL+    R+++D  
Sbjct: 1320 QPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-- 1377

Query: 816  NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875
              +     KR R+QS A  + +E   L  ++T +  +     Q ++FA + L++  E E 
Sbjct: 1378 -SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL---MTQYIKFAGDSLKRLEEEEK 1433

Query: 876  THETLQRNRPDSGVE-EAW--KIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESV 932
            + E  ++   +   E + W   I K L +  +  +   ++ K + EEI T + Q      
Sbjct: 1434 SLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQ------ 1487

Query: 933  VRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEY 992
                         L E+ Q +Q  LA  +H +++  EE   L+ Q++ L++         
Sbjct: 1488 -------------LSEALQTIQLFLA--KHGDKMTDEERNELEKQVKTLQE-----SYNL 1527

Query: 993  VVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKV 1052
            +  E L+ +   +Q    +++ E++ A R+Q+          ++++  + +  ++ + ++
Sbjct: 1528 LFSESLK-QLQESQTSGDVKVEEKIVAERQQE---------YKEKLQGICDLLTQTENRL 1577

Query: 1053 TEKEVVKLQNDPQLE-AEYQQLQEDHQRQDQ-----LREKQEEELSFLQDKLKRLEKE-R 1105
               +   +  D  +E  +YQ  QE+ Q+  Q     L E  +   +FL++  ++L +E +
Sbjct: 1578 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1637

Query: 1106 AMAEGKITVKEV------LKVEKD-AATEREVSDLTRQYEDEAAKARASQREKTELLRKI 1158
            A+ E K+   ++      LK E+     ++ V+   ++  ++ A  +  +  KT++   +
Sbjct: 1638 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1697

Query: 1159 -WA----LEEENA----KVVVQEKVREIVRPDPKA---ESEVANLRLELVEQERKYRGAE 1206
             W      + E A    K V+++        D K+   E +  N  L   + + +    +
Sbjct: 1698 DWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ 1757

Query: 1207 EQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCD 1266
            E L     +++A   +   +  +     +        +EK+ Q L  E  +K +     +
Sbjct: 1758 ENLNQQYQKVKAQHEK---IISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----N 1810

Query: 1267 LEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQED--------PQTKEEVASLRAKLSEE 1318
            ++  ++  E    +  K    T  + +E+ +F  D         Q+++E+ +L A   + 
Sbjct: 1811 MKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDI 1870

Query: 1319 QKKQVDLERERASQEEQIARKEE-ELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDV 1377
                  L+R+++  E+ I+ K +     +    V +      +  G + + SA    +  
Sbjct: 1871 NGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQ- 1929

Query: 1378 ELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEA 1437
              R++D      R L  +   L   L++L  + Q   +A   +      LA L+  EA A
Sbjct: 1930 --RKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL------LAGLQACEATA 1981

Query: 1438 REKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKE 1497
             + ++    V    DP+       L+ QLEE     + L+G++ +   +  A+EK +   
Sbjct: 1982 SKHLSEPIAV----DPKN------LQRQLEE----TKALQGQISS---QQVAVEKLKKTA 2024

Query: 1498 KVVLSE--SVQVEKGDTEQEIQRLKSSLEEESRSKRE----LDVEVSR---LEARLSEL- 1547
            +V+L    S+   K D ++ +  +    E+ S+S  E    L + ++R   ++  L E+ 
Sbjct: 2025 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 2084

Query: 1548 -EFHNSKSS-KELDFLREENHKLQ-LERQNLQLE--TRRLQSEINMAATETRDLRNMTVA 1602
                N +SS KE   +   +  LQ +  +N+ LE      QS IN    + +     T  
Sbjct: 2085 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 2144

Query: 1603 DSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRL 1640
             + ++  +++  L     +     K+   +++EL+ ++
Sbjct: 2145 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 2182



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 326/1767 (18%), Positives = 699/1767 (39%), Gaps = 272/1767 (15%)

Query: 16   TVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKV 75
            TV+ +   +K+  EL + +Q +A  + + + +TE  ++ +  +L +    E + +  QK+
Sbjct: 1590 TVELKKYQSKQ-EELQKDMQGSAQALAEVVKNTENFLKENGEKLSQ----EDKALIEQKL 1644

Query: 76   LDSEKLLYVL---------EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRG------- 119
             +++     L         E D  +   +K     + A  ++QL+E  T +         
Sbjct: 1645 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA--VKQLEESKTKIENLLDWLSN 1702

Query: 120  ----------KHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV---- 165
                      KHKQ+              +A+ EE  D++N     TD   VD QV    
Sbjct: 1703 VDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEE--DEVNGNLLETD---VDGQVGTTQ 1757

Query: 166  EEHNIFHNEVKA-----IGPHLA-----------------------KDGDKEQNSELRAK 197
            E  N  + +VKA     I  H A                       K+  ++   EL+  
Sbjct: 1758 ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVH 1817

Query: 198  YQKLLAASQARQQHLSSLQDYMQRC----TNELYWLDQQAKGRMQYDWSDRNLDYPSRRR 253
            Y+  LA S+ + +   SLQ+ +++     T   +WL Q  +     +    +++    + 
Sbjct: 1818 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1877

Query: 254  QYENFINRNLEAKEERINKLHSEGDQLLAAEHP--GRNSIEAHMEAVHADWKEYLNLLI- 310
            + +   + ++ + +  +  +   G+++L A      R+  +    A H + +  L+    
Sbjct: 1878 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1937

Query: 311  --------CEE--SHLKYMEDYHQFHEDVK-----DAQELLRKVDSDLNQKYGPDFKD-R 354
                    C    ++LK + D +Q +ED         Q         L++    D K+ +
Sbjct: 1938 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 1997

Query: 355  YQIE---LLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPI-----PVEA 406
             Q+E    L  ++  Q+  ++K +   + L      ++P K   +  L  I      +  
Sbjct: 1998 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 2057

Query: 407  LCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSL 466
              +   E+  I+   S ++Q    E  + M +  + L          P +  AL     +
Sbjct: 2058 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQV----PLNSTAL---QDI 2110

Query: 467  GSQYRSVRQKAAGSKRTLQQRYEVLK----TENPGDASDLQGRQLLAGLDKVASDLDRQE 522
             S+   + Q  AG + ++    E +K    T +P  AS LQ +  +  L    S+   + 
Sbjct: 2111 ISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAK--MKDLSARFSEASHKH 2168

Query: 523  KAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGT 582
            K          E    +++   + +  +N++ +L      KT++  E +     +PG   
Sbjct: 2169 K----------ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVD-----VPGKDV 2213

Query: 583  TPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQ----- 637
            T L +   E T+   EH   L  L     ++++     L     L+    N+L++     
Sbjct: 2214 TELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH---GLPSDKALVLEKTNNLSKKFKEM 2270

Query: 638  DDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVE------------QNLQAAKQCSST 685
            +DT+ E    + S  ++L A    +++ KS + E              ++L  + + +  
Sbjct: 2271 EDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2330

Query: 686  LASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAA------------YE 733
            L  ++    P++++    V+  G    NL   V   A+++ + K+              E
Sbjct: 2331 LQEKWSLKTPEIQK----VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2386

Query: 734  HF--HRGHDHVLQFLVSIP-SYEPQET---DSLSQMETKLKNQKNLLDEIASREQEVQKI 787
             F  ++G   + + +  I   YE       D ++++ TKL   +   +E ++  Q +QK+
Sbjct: 2387 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKM 2446

Query: 788  CANSQQYQQAVKDYELEAEK--LRSLLDLENGRSSHVSKRARLQSPATKVKEE--EAALA 843
               + ++QQ     + EA K  +      E     +V+K   L+   T++ EE  +   A
Sbjct: 2447 NKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2506

Query: 844  AKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEET 903
             ++ ++      + Q L   L + RQQ   E ++   Q    ++ +++ W + KEL    
Sbjct: 2507 PRWKQMLTEIDSKWQELN-QLTIDRQQKLEESSNNLTQFQTVEAQLKQ-WLVEKELMVSV 2564

Query: 904  ERRRQLENEVKSTQ--------EEIWTLRNQGPQESVVRKEVLKKV-PDPVLEESFQQLQ 954
                 ++  + +TQ        +E  T + Q  Q +   + +L +   DP L    ++  
Sbjct: 2565 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2624

Query: 955  RTLAEE---------QHKNQLLQEELEALQLQ--LRALEQETRDGGQEYVVKEVLRIEPD 1003
              + ++            + + Q  +++ Q Q  LR+L  +  D   +      +   PD
Sbjct: 2625 AAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2684

Query: 1004 --RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQ 1061
                Q +   ++++E++  ++Q    +A   L +   A + EE  +A+     + ++K  
Sbjct: 2685 AMNQQLETAQKMKQEIQQEKKQIKVAQA---LCEDLSALVKEEYLKAELSRQLEGILKSF 2741

Query: 1062 NDPQLEAE--YQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLK 1119
             D + +AE   Q LQ       Q ++   +  ++L  K +   K   ++     ++ ++K
Sbjct: 2742 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2801

Query: 1120 VEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVR 1179
              KD +  + ++  +  YE   A       E   LL K    E    K  +Q ++  I  
Sbjct: 2802 DHKDFS--KTLTAQSHMYEKTIA-------EGENLLLKTQGSE----KAALQLQLNTI-- 2846

Query: 1180 PDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYK 1239
               K   +  N +++  E+E K + + E+   Y+ ++E L    P ++  +   E IK+ 
Sbjct: 2847 ---KTNWDTFNKQVK--ERENKLKESLEKALKYKEQVETL---WPWIDKCQNNLEEIKFC 2898

Query: 1240 TDPEMEK----ELQRLREEIVDKTRLIERCD------LEIYQLKKEIQALKDTKPQVQTK 1289
             DP   +    +L+ L++E+     ++E  +      L + ++ KE+    + K  +Q  
Sbjct: 2899 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV-VTDENKSLIQKV 2957

Query: 1290 EVVQEILQFQE-DPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQI---ARKEEELSR 1345
            ++V E L  ++   +   +      ++S+E K+Q+   +E+    + +   A   + L+ 
Sbjct: 2958 DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTM 3017

Query: 1346 VKERVVQQEVVRYEEEPGLRAEASAFAESIDVE-----LRQIDKLRAELRRLQRRRTE-- 1398
            ++ +    + ++++ +   R       E+ D +     L Q++ +  E   L ++  E  
Sbjct: 3018 LQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 3077

Query: 1399 --LERQLEELERERQARREAEREVQRLQQRLAALEQ--EEAEAREKVTHTQKVVLQQ--- 1451
              LE +L+ +   +   RE   +       L ++     +AE  +K   T K  L++   
Sbjct: 3078 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 3137

Query: 1452 ---DPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKL-AALEKAEVKEKVVLSESVQV 1507
                   A +   + L  EE       ++ +LE L ++    L++A+ +E+ V     ++
Sbjct: 3138 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 3197

Query: 1508 EKGDTE-QEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566
            E+  ++ +E   L    EE   S+  + +E   +  +L+  +           F +EE  
Sbjct: 3198 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV----------FQKEEIE 3247

Query: 1567 KLQLERQNLQ-LETRRLQSEINMAATE 1592
             LQ ++Q++  L    +QS     +T+
Sbjct: 3248 PLQGKQQDVNWLGQGLIQSAAKSTSTQ 3274



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 170/848 (20%), Positives = 339/848 (39%), Gaps = 150/848 (17%)

Query: 570  GEAFIQALPGSGTTPLLRTRVEDTNRKYEHL----LQLLDLAQEKVDVANRLEKSLQQ-- 623
            G+  IQ+   S +T  L   ++D N +++ L     Q     QE +    R + +L+   
Sbjct: 3260 GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLL 3319

Query: 624  SWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQK---SLLGEVEQNLQAAK 680
            SW ++ T E   NQ    P S+        E   +  ++Q QK    LL + +  ++  K
Sbjct: 3320 SW-MVDTEELVANQK---PPSA--------EFKVVKAQIQEQKLLQRLLDDRKSTVEVIK 3367

Query: 681  QCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHD 740
            +    +A+  +    D  +   ++  L  R+  L  + E R + L+      + FH   +
Sbjct: 3368 REGEKIATTAEP--ADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3425

Query: 741  HVLQFLVSIP----SYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQ 796
             + ++L +I     + EP  T + S++E ++   K L D+I +  + + +  +  Q  + 
Sbjct: 3426 PLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLK- 3483

Query: 797  AVKDYELEAEKLRSLLD------LENGRSSHVSKRARLQSPATKVK---EEEAALAAKFT 847
             V     + + ++S LD      +E    SH S+   LQ      K   E+E  L     
Sbjct: 3484 -VLSSREDKDMVQSKLDFSQVWYIEIQEKSH-SRSELLQQALCNAKIFGEDEVELMNWLN 3541

Query: 848  EVY-AINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPD------SGVE---------- 890
            EV+  +++  +Q+      L +QQ E+ V  E +   + +      +G+E          
Sbjct: 3542 EVHDKLSKLSVQDYSTE-GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3600

Query: 891  ---------------EAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRK 935
                           +  K+  ++ +  E+  QL   + ST EE+ T  ++      V  
Sbjct: 3601 LIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK------VEV 3654

Query: 936  EVLKKVPDPVLEESFQQLQ---RTLAEEQHKNQLLQEEL-EALQLQLRALEQETRDGGQE 991
            E+L      +  E   Q Q   + L +E   N+ L + L E     L  +    R+G ++
Sbjct: 3655 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3714

Query: 992  YVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEK 1051
             V ++  R    R  +D + Q  EE++A           +L  QQ   A   E S   E 
Sbjct: 3715 MVAEDNERY---RLVSDTITQKVEEIDAA----------ILRSQQFDQAADAELSWITE- 3760

Query: 1052 VTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGK 1111
             TEK+++ L  D +LE            QDQ   + + + +F  + L+  +    + +  
Sbjct: 3761 -TEKKLMSL-GDIRLE------------QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3806

Query: 1112 ITVKEVLKVEKDAATEREVSDLTRQYED--EAAKARASQREKTE-LLRKIWALEEENAKV 1168
              +      E+  + ++++  + + Y+   +    R  Q E+ + L+ + W   EE    
Sbjct: 3807 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3866

Query: 1169 VVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQ--- 1225
            + + +      P P  E E       L +Q+ ++R   E +  ++  ++ + + GPQ   
Sbjct: 3867 LTETQSIISQLPAPALEYET------LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3920

Query: 1226 --------VEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQ 1277
                    ++ K V  + +  +   +++K    L E I   T+  ++ D  +  L++ ++
Sbjct: 3921 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 3980

Query: 1278 ALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIA 1337
             L+                   + P    EV  ++ ++SE +   VD+E+ +   E    
Sbjct: 3981 RLR-------------------QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ 4021

Query: 1338 RKEEELSR 1345
            R EE ++R
Sbjct: 4022 RGEEMIAR 4029



 Score = 71.2 bits (173), Expect = 8e-12
 Identities = 264/1303 (20%), Positives = 495/1303 (37%), Gaps = 209/1303 (16%)

Query: 455  TDPEALALADSLGSQYRSVRQKAAGSKRTLQQ-RYEVLKTENPGDASDLQGRQLLAGLDK 513
            T P+ L L+   G    S+++K   +     Q + +V K     D +  Q  Q    +D+
Sbjct: 3914 TGPQLLELSPGEGF---SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3970

Query: 514  VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573
            +   L+R    I   LR P      V+   E+  + KN++ ++ +++P        GE  
Sbjct: 3971 ILESLER----IVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026

Query: 574  IQALPGSG---TTPLLRTRVEDTNRKYEHLLQLLDLAQEK-VDVANRLEKSLQQSWELLA 629
            I    G+    +   ++ +++     +E++  L++  + K +DV    EK       L+ 
Sbjct: 4027 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 4086

Query: 630  THENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASR 689
            T ++         +  R L+  G + + +  + +A +++  E++  LQ        L S 
Sbjct: 4087 TIKD-------TQDFIRDLEDPGIDPSVVKQQQEAAETIREEID-GLQEELDIVINLGSE 4138

Query: 690  FQEHC--PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLV 747
                C  PD    +  + +L   +++L +  + R   L+ A  A   +  G    LQ + 
Sbjct: 4139 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG----LQAVF 4194

Query: 748  SIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEK 807
                    +  S+S + T L+  K  ++E+             S+ YQQ     ++E E+
Sbjct: 4195 DWVDIAGGKLASMSPIGTDLETVKQQIEELKQ---------FKSEAYQQ-----QIEMER 4240

Query: 808  LRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLL 867
            L    +L   + +  S +  +Q P  ++K     L     E   INRQ    LE AL  L
Sbjct: 4241 LNHQAELLLKKVTEESDKHTVQDPLMELK-----LIWDSLEERIINRQ--HKLEGALLAL 4293

Query: 868  RQQPE--------VEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEE 919
             Q           +  T   L   +P  G  +A +I      E  +   L+N+V + Q  
Sbjct: 4294 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI------ELAKHHVLQNDVLAHQST 4347

Query: 920  IWTLRNQGPQ--ESVVRKEVLKKVPDPVLEESFQQLQRTLAE-EQHKNQL---------L 967
            +  +   G    ES   +E         LE   Q+ Q  L + EQ K QL          
Sbjct: 4348 VEAVNKAGNDLIESSAGEEASNL--QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGF 4405

Query: 968  QEELEALQLQLRALEQETRD----GGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQ 1023
              E+E LQ  L   E+        GG     KE L +  +   A E    +EE      Q
Sbjct: 4406 HGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA---KEETYKSLMQ 4462

Query: 1024 KGAR------EAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDH 1077
            KG +      ++    + Q +  L E+    + K+ E++  KL+    L  E+    +D 
Sbjct: 4463 KGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK-TKLEEALNLAMEFHNSLQDF 4521

Query: 1078 -----QRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSD 1132
                 Q +  L       L  L   L +++      E K+   EV    ++   E + + 
Sbjct: 4522 INWLTQAEQTLNVASRPSL-ILDTVLFQID------EHKVFANEV-NSHREQIIELDKTG 4573

Query: 1133 LTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVR-----EIVRPDPKAESE 1187
               +Y         SQ++   L++ +    +   + VVQ  V      +  R   K   E
Sbjct: 4574 THLKY--------FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4625

Query: 1188 VANLRLELVEQERKYRGAE-----------EQLRSYQSELEALRRRGPQVEVKEVTKEVI 1236
              +  +E +E+  K   +E            QL  ++   ++L  +    +    T   +
Sbjct: 4626 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4685

Query: 1237 KYKT-----DPEMEKELQRLRE-------EIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
            K KT     + +++  L  LR+       + V++   +E   L   Q    +QAL D   
Sbjct: 4686 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4745

Query: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
            +V+ +    + +    D      + + +A   E  K+   ++  + S  E I    ++ S
Sbjct: 4746 RVEPQLAEDQPVHGDID-LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS 4804

Query: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
             VK + +Q+   R+E    L          ++  LRQ ++  + +  L     E E+ L 
Sbjct: 4805 WVKVQ-MQELSTRWETVCALSISKQT---RLEAALRQAEEFHSVVHALLEWLAEAEQTLR 4860

Query: 1405 ---ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVT--HTQKVVLQQDPQQAREH 1459
                L  +  A R     + + ++ +  LE++ AE  +  T   T   +   D     +H
Sbjct: 4861 FHGVLPDDEDALRTL---IDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKH 4917

Query: 1460 --ALLRLQLEE-----EQHRRQL------LEGELETLRRKLAALEKAEV----KEKVVLS 1502
               ++R + EE     +QH+++L      L  + E L   LA L+ AE     K+K V+ 
Sbjct: 4918 WITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 4977

Query: 1503 ESVQ------VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSK 1556
            + ++       E     +E+ R +  +++ +++ +    + S L++ +  L+   +   +
Sbjct: 4978 QEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKR 5037

Query: 1557 -ELDFLREENHKLQLERQN---------------LQLETRRLQSEINMAATETRDLRNMT 1600
                 L     + Q+E +N               L LE RR   ++N A     +LR   
Sbjct: 5038 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR---KLNDALDRLEELREF- 5093

Query: 1601 VADSGTNHDSRLW----------SLERELDDLKRLSKDKDLEI 1633
                  N D  +W             R +D  +R+ KD+D +I
Sbjct: 5094 -----ANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKI 5131



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 250/1287 (19%), Positives = 495/1287 (38%), Gaps = 203/1287 (15%)

Query: 454  PTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDK 513
            PTD EA+         + +  ++     + L+ +   L  ENP      + +Q+L  +D 
Sbjct: 2459 PTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDS 2518

Query: 514  VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573
               +L++                    D  ++ ++  N   +   +E +  +   E E  
Sbjct: 2519 KWQELNQ-----------------LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2561

Query: 574  IQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHEN 633
            +  L      P     + +T R+   +L L + A  K            Q  +L A  + 
Sbjct: 2562 VSVLGPLSIDP----NMLNTQRQQVQIL-LQEFATRK-----------PQYEQLTAAGQG 2605

Query: 634  HLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGE-------VEQNLQAAKQCSSTL 686
             L++    P    ++    ++LAA+    Q   SL G+       ++Q +  + Q  S L
Sbjct: 2606 ILSRPGEDPSLRGIVK---EQLAAVT---QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLL 2659

Query: 687  ASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFL 746
             S   +   DL+ + +    +    + + QQ+E   +  Q  +   +   +    + + L
Sbjct: 2660 RS-LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI-KVAQALCEDL 2717

Query: 747  VSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYE--LE 804
             ++   E  + +   Q+E  LK+ K++  +  +  Q +Q  CA+S Q+QQ  +D++  L+
Sbjct: 2718 SALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLD 2777

Query: 805  AEK---------------LRSLLDLENGRS------SHVSKRARLQSPATKVK---EEEA 840
             +K               L SL+      S      SH+ ++   +     +K    E+A
Sbjct: 2778 TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKA 2837

Query: 841  ALAAKFTEVY----AINRQ-------RLQNLEFALNLLRQ-----------QPEVEVTHE 878
            AL  +   +       N+Q         ++LE AL    Q           Q  +E    
Sbjct: 2838 ALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF 2897

Query: 879  TLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKS------TQEEIWTLRNQGPQESV 932
             L     ++ + +   ++KE+D+       L N   S        +E+ T  N       
Sbjct: 2898 CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDEN------- 2950

Query: 933  VRKEVLKKVPDPVLEESFQQ---LQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGG 989
              K +++KV D V E+   +   L+    + +   ++ +E    LQ     L+     G 
Sbjct: 2951 --KSLIQKV-DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGS 3007

Query: 990  QEYVVKEVLRIEPD-------RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALA 1042
            Q Y  K +  ++         + Q D   +L ++L  +        ++VLL   +V  +A
Sbjct: 3008 QAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL-VVEASDSKGTSDVLL---QVETIA 3063

Query: 1043 EEKSRAQEKVTEK---EVVKLQN----DPQLEAEYQQLQEDHQRQDQLR---------EK 1086
            +E S   ++V EK      KLQ        +   + Q  E     D +          +K
Sbjct: 3064 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 3123

Query: 1087 QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDA----ATEREVSDLTRQYED--E 1140
            Q+E +     KL+ L      A    T K +L  E+ +      +R++  L++Q     +
Sbjct: 3124 QKETIKAFLKKLEALMASNDNANK--TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD 3181

Query: 1141 AAKARASQREKT-ELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQE 1199
             A+AR  Q E T + L + ++  +E + ++ + +  E  +     E+E  N +L + +  
Sbjct: 3182 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 3241

Query: 1200 RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKT 1259
            +K     E L+  Q ++  L +   Q   K  + + +++  D ++    + L +++  + 
Sbjct: 3242 QKEE--IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD-DVNARWKTLNKKVAQRA 3298

Query: 1260 RLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQ 1319
              ++   L   + +  +++L      V T+E+V      Q+ P  + +V   +    +EQ
Sbjct: 3299 AQLQEALLHCGRFQDALESLLSW--MVDTEELVAN----QKPPSAEFKVVKAQI---QEQ 3349

Query: 1320 KKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVEL 1379
            K    L  +R S  E I R+ E+++   E   + ++                       L
Sbjct: 3350 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKI-----------------------L 3386

Query: 1380 RQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEARE 1439
            +Q+  L +    L  +     RQLE +    Q   E    ++ L + L  +E+       
Sbjct: 3387 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET---LEPLNEWLTTIEKRLVNCEP 3443

Query: 1440 KVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKV 1499
              T   K+    + Q A+  AL    +   +H  Q +    ++L+   +  +K  V+ K+
Sbjct: 3444 IGTQASKL----EEQIAQHKALEDDIINHNKHLHQAVSIG-QSLKVLSSREDKDMVQSKL 3498

Query: 1500 VLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVS-RLEARLSELEFHNSKSSKEL 1558
              S+   +E     QE    +S L +++    ++  E    L   L+E+    SK S + 
Sbjct: 3499 DFSQVWYIE----IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ- 3553

Query: 1559 DFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERE 1618
            D+  E   K Q E + LQ +    +  ++ A     +L   T  D       +L +++  
Sbjct: 3554 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKAR 3613

Query: 1619 LDDLKRLSKD--KDLE-IDELQKRLGS 1642
              D+ +LS D  K LE   +L +RL S
Sbjct: 3614 YKDITKLSTDVAKTLEQALQLARRLHS 3640



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 211/1170 (18%), Positives = 466/1170 (39%), Gaps = 171/1170 (14%)

Query: 585  LLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPES 644
            +++ ++E    +Y+      D+ +   DVA  LE++LQ +  L +THE      D V   
Sbjct: 3602 IIQDKLEAIKARYK------DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3655

Query: 645  SRVLDS---KGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQ- 700
                ++   KG+E    A + Q +   L +  +N +A     + ++S   E  P   R+ 
Sbjct: 3656 LLSYETQVLKGEE----ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG 3711

Query: 701  -EAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQF-------LVSIPSY 752
             E  V +  +R+  +   + ++ + + +A    + F +  D  L +       L+S+   
Sbjct: 3712 LEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDI 3771

Query: 753  EPQETDSLSQMET------KLKNQKNLLDEIASREQEVQKICANSQ------QYQQAVKD 800
              ++  + +Q++       ++   K+++D++     ++   C+  +      +  + +K+
Sbjct: 3772 RLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3831

Query: 801  Y----ELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQR 856
            Y    ++ +E+   L   ++  +        L    T+ +   + L A   E   + +Q+
Sbjct: 3832 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3891

Query: 857  LQNLEFALNLLRQQPEVEVTHET---LQRNRPDSG--VEEAW----KIRKELDEETERRR 907
             ++ +    +   +P ++  ++T   L    P  G  ++E +     +  ++ E+ ++R 
Sbjct: 3892 EEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRA 3951

Query: 908  QLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLL 967
               +E  S   +     +Q   ES+ R  +++++  P    S       + E+  +N+ +
Sbjct: 3952 VALDEAISQSTQFHDKIDQ-ILESLER--IVERLRQP---PSISAEVEKIKEQISENKNV 4005

Query: 968  QEELEALQ-----LQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRR 1022
              ++E LQ     L+ R  E   R GG +    + +  +  + + D+++ + E +  L  
Sbjct: 4006 SVDMEKLQPLYETLKQRGEEMIARSGGTD----KDISAKAVQDKLDQMVFIWENIHTLVE 4061

Query: 1023 QKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQ 1082
            ++ A+  +V+ L ++     +  S        ++ ++   DP ++          ++Q +
Sbjct: 4062 EREAKLLDVMELAEKF--WCDHMSLIVTIKDTQDFIRDLEDPGIDPSVV------KQQQE 4113

Query: 1083 LREKQEEELSFLQDKLK---RLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYED 1139
              E   EE+  LQ++L     L  E   A G          E D    ++  D      D
Sbjct: 4114 AAETIREEIDGLQEELDIVINLGSELIAACG----------EPDKPIVKKSIDELNSAWD 4163

Query: 1140 EAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLR-----LE 1194
               KA   + +K E        E   A V  Q+ ++ +      A  ++A++      LE
Sbjct: 4164 SLNKAWKDRIDKLE--------EAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 4215

Query: 1195 LVEQE-RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKT-DPEMEKEL--QR 1250
             V+Q+  + +  + +    Q E+E L  +  ++ +K+VT+E  K+   DP ME +L    
Sbjct: 4216 TVKQQIEELKQFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDS 4274

Query: 1251 LREEIVDKTRLIERCDLEIYQLKKEIQ-----------ALKDTKPQVQTKEVVQEILQFQ 1299
            L E I+++   +E   L + Q +  +             L + KP     + ++  ++  
Sbjct: 4275 LEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE--IELA 4332

Query: 1300 EDPQTKEEVASLRAKLSEEQKKQVDLERERASQE-EQIARKEEELSRVKERVVQQEVVRY 1358
            +    + +V + ++ +    K   DL    A +E   +  K E L++  + V+++   R 
Sbjct: 4333 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4392

Query: 1359 EEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAER 1418
            ++              +D  LRQ      E+  LQ+  T+ ER L   +        A+ 
Sbjct: 4393 QQ--------------LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKE 4438

Query: 1419 EVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEG 1478
            ++    +  AA E +E         T K ++Q+  Q      L R     E +    ++ 
Sbjct: 4439 QLNVHMEVCAAFEAKE--------ETYKSLMQKGQQM-----LARCPKSAETN----IDQ 4481

Query: 1479 ELETLRRKLAALE------KAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRE 1532
            ++  L+ K  ++E      K +++E + L+        D    + + + +L   SR    
Sbjct: 4482 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4541

Query: 1533 LDVEVSRLEAR---LSELEFHN------SKSSKELDFLREENHKLQLERQNLQLETRRLQ 1583
            LD  + +++      +E+  H        K+   L +  ++   + +  +NL +  +   
Sbjct: 4542 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLI--KNLLISVQSRW 4599

Query: 1584 SEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEI----DELQKR 1639
             ++     E    R++  A          WS   E  +    S D +LEI    D+++ +
Sbjct: 4600 EKVVQRLVERG--RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ 4657

Query: 1640 LGSVAVKREQRENHLRRSIVVIHPDTGREL 1669
            L     K  Q+    + S+      TGR L
Sbjct: 4658 LAQ--HKEFQKSLGAKHSVYDTTNRTGRSL 4685



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 196/1134 (17%), Positives = 447/1134 (39%), Gaps = 143/1134 (12%)

Query: 599  HLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAM 658
            H    L  +++K+ + + L++ L++        E+ L Q +   E+   L++   ++  +
Sbjct: 1817 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELEN---LEAGADDINGL 1873

Query: 659  ACELQAQKSLLGEVEQN--------------LQAAKQCSSTLASRFQEHCPDLERQEAEV 704
              +L+ QKS   +V  +              L+AAK CS     +        E Q    
Sbjct: 1874 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1933

Query: 705  HKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQ-- 762
            H    RF +L  +      +L+     Y+H+    D     L  + + E   +  LS+  
Sbjct: 1934 HAT-DRFRSLYSKCNVLGNNLKDLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPI 1989

Query: 763  ------METKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLEN 816
                  ++ +L+  K L  +I+S++  V+K+   ++    A          ++  LD   
Sbjct: 1990 AVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIV 2049

Query: 817  GRSSHVSKRA-----RLQSPATKVKEEEAAL------------AAKFTEVYAINRQRLQ- 858
            GR   +SK       +LQ   T+    +  L            + K      +N   LQ 
Sbjct: 2050 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQD 2109

Query: 859  ----NLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVK 914
                N+    ++  +Q  +   +E +++    +    A  ++ ++ + + R  +  ++ K
Sbjct: 2110 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 2169

Query: 915  STQEEIWTLRN------------QGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE-Q 961
             T  ++  L+             Q   E+  +      VP   + E  Q +Q + +E  +
Sbjct: 2170 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 2229

Query: 962  HKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPD-RAQADEVLQLREELEAL 1020
            HK     + LE L   L+ +        +  V+++   +    +   D + + +E + + 
Sbjct: 2230 HK-----KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC 2284

Query: 1021 RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVK-LQNDPQLEAEYQQLQEDHQR 1079
            + Q  A +  V  L+  +    ++    Q     +++ K L++  +L+ ++     + Q+
Sbjct: 2285 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2344

Query: 1080 QDQLREKQEEELSFLQDKLKRLEKERA-----MAEGKITVKEVLKVEKDAAT-EREVSDL 1133
             +         +S +    K +   ++       EG  T  E     K   + +++++D+
Sbjct: 2345 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2404

Query: 1134 TRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRL 1193
            +  YED     +    E    L K+   +EE++   + + ++++ +   K +   A    
Sbjct: 2405 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS--AMMQWLQKMNKTATKWQQTPAPTDT 2462

Query: 1194 ELVE-QERKYRGAEEQLRSYQSELEALRRRGPQ-VEVKEVTKEVIKYKTD-PEMEKELQR 1250
            E V+ Q  + +  E +L+   ++++ L+ +  + +E    T E  ++K    E++ + Q 
Sbjct: 2463 EAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQE 2522

Query: 1251 LREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDP-QTKEEVA 1309
            L +  +D+ + +E     + Q +     LK     V+ + +V  +     DP     +  
Sbjct: 2523 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQW--LVEKELMVSVLGPLSIDPNMLNTQRQ 2580

Query: 1310 SLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEAS 1369
             ++  L E   ++   E+  A+ +  ++R  E+ S ++  V +Q     ++   L  + S
Sbjct: 2581 QVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPS-LRGIVKEQLAAVTQKWDSLTGQLS 2639

Query: 1370 AFAESIDVELRQIDKLRAELRRLQRRRTELERQL--------------EELERERQARRE 1415
               + ID  + +  + ++ LR L  + ++L+ +L              ++LE  ++ ++E
Sbjct: 2640 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2699

Query: 1416 AERE------VQRLQQRLAALEQE---------------------EAEAREKVTHTQKVV 1448
             ++E       Q L + L+AL +E                     E +A   V H Q   
Sbjct: 2700 IQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSAC 2759

Query: 1449 L--QQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQ 1506
                Q  Q +R+        +EEQ++   +  +L+ L    + ++  +   K + ++S  
Sbjct: 2760 ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLE---SLIKDHKDFSKTLTAQSHM 2816

Query: 1507 VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566
             EK   E E   LK+   E++  + +L+   +  +    +++   +K  + L+  +   +
Sbjct: 2817 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE--KALKY 2874

Query: 1567 KLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELD 1620
            K Q+E          L   I+       +++       G N  ++L SL++E+D
Sbjct: 2875 KEQVE---------TLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMD 2919



 Score = 35.4 bits (80), Expect = 0.49
 Identities = 67/320 (20%), Positives = 133/320 (41%), Gaps = 57/320 (17%)

Query: 26   ELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVL 85
            +L E +E+ +K+ D  E  I +   K+++ LA+ +E           QK L ++  +Y  
Sbjct: 4629 KLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKE----------FQKSLGAKHSVY-- 4675

Query: 86   EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKE-------------- 131
              D          +   +A+D  +L + ++ LR K   I   +V+               
Sbjct: 4676 --DTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4733

Query: 132  ---VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNE-------VKAIGPH 181
               +   ++W   VE +L +  +Q    D+ LV + ++ H  F  E       V+A+   
Sbjct: 4734 TDALQALIDWLYRVEPQLAE--DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4791

Query: 182  LAK--DGDKEQNS-------ELRAKYQKLLAASQARQQHLSSL----QDYMQRCTNELYW 228
              +  +G ++ +S       EL  +++ + A S ++Q  L +     +++       L W
Sbjct: 4792 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4851

Query: 229  LDQQAKG-RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPG 287
            L +  +  R      D      +   Q++ F+ + LE K   +NK  + GD +LA  HP 
Sbjct: 4852 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKK-LEEKRAELNKATTMGDTVLAICHPD 4910

Query: 288  R-NSIEAHMEAVHADWKEYL 306
               +I+  +  + A ++E L
Sbjct: 4911 SITTIKHWITIIRARFEEVL 4930



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 70/347 (20%), Positives = 138/347 (39%), Gaps = 43/347 (12%)

Query: 110  LKERVTNLRGKHKQIYRLAVKE----VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV 165
            L+ER+ N + K +    LA+ +    +D  + W    E  L +   +  G D   ++ ++
Sbjct: 4275 LEERIINRQHKLEGAL-LALGQFQHALDELLAWLTHTEGLLSE--QKPVGGDPKAIEIEL 4331

Query: 166  EEHNIFHNEVKA----------IGPHLAKDGDKEQNSELRAK-------YQKLLAASQAR 208
             +H++  N+V A           G  L +    E+ S L+ K       +Q +L  ++ R
Sbjct: 4332 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQR 4391

Query: 209  QQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLD-YPSRRRQYENF---INRNLE 264
            +Q L       +    E+  L Q      ++  + + L   P   ++  N    +    E
Sbjct: 4392 KQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4451

Query: 265  AKEERINKLHSEGDQLLA-AEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYH 323
            AKEE    L  +G Q+LA        +I+  +  +   W+     L   E   K  E  +
Sbjct: 4452 AKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKL--NERKTKLEEALN 4509

Query: 324  ---QFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQE---KVLDKYEDV 377
               +FH  ++D    L + +  LN    P       ++ +L ++D+ +     ++ + + 
Sbjct: 4510 LAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEVNSHREQ 4565

Query: 378  VQGLQKRGQQVVPLKYRRETPL-KPIPVEALCDFEG-EQGLISRGYS 422
            +  L K G  +     +++  L K + +     +E   Q L+ RG S
Sbjct: 4566 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4612



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 12/85 (14%)

Query: 103  IAEDIRQLKER-------VTNLRGKHKQIYRLAVK---EVDPQVNWAALVEEKLDKLNNQ 152
            I +DI  LKE+       +   + K ++   LA++    +   +NW    E+ L+  +  
Sbjct: 4479 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4538

Query: 153  SFGTDLPLVDHQVEEHNIFHNEVKA 177
            S   D  L   Q++EH +F NEV +
Sbjct: 4539 SLILDTVLF--QIDEHKVFANEVNS 4561


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score =  311 bits (798), Expect = 3e-84
 Identities = 356/1658 (21%), Positives = 728/1658 (43%), Gaps = 226/1658 (13%)

Query: 129  VKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHL--AKDG 186
            +K V   +NW   V+E   +L+   +G+DLP V+  +E H   H  ++     L  AK  
Sbjct: 279  MKFVQDLLNW---VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 335

Query: 187  DKEQNSELR-----------AKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKG 235
            + +  + L+           ++Y KLL  S+ +++HL +L +++ R TNEL WL+++ + 
Sbjct: 336  EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE 395

Query: 236  RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHM 295
             + YDWS+RN +  +R++ Y   + R L+ KEE I  +    +QLL   HP R +IEA+ 
Sbjct: 396  EVAYDWSERNTNI-ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 296  EAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDR- 354
             A+   W   L L  C E H+K    Y +F  D K+A + LR +   + +KY  D     
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 355  YQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRR-ETPLK-PIPVEALCDFEG 412
            +++E L++E  ++++ L +Y+  +  L  + + ++ LK R  + PLK  IP++A+CD+  
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 413  EQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR 471
             +  I +     L  N+  + W+++   GN+ + P+VCF +PP + EA+ LA+ +  QY+
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 472  SV----RQKAAGSKRTLQQRYEV-------------LKTENPGD----ASDLQGR----- 505
            +V     +     K  +   Y +             +KT  PG+     S+LQ R     
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 506  ------QLLAGLDKV------------------ASDLDRQEKAITGI------------- 528
                  Q+ +G D                    +++ + QE+++  +             
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754

Query: 529  ---------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579
                     +R PLE+   + +S  R  + + +  EL R++ +    T + E F      
Sbjct: 755  NCEDRLIRQIRTPLERD-DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA 813

Query: 580  SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDD 639
            S + P LR+ +    +    +  +     +K+   N + K+ Q +  L+  +E  L +++
Sbjct: 814  SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEE 873

Query: 640  TVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLER 699
             V      +++    L     E+  ++ +   +E  LQ AK  S  +   ++E   D + 
Sbjct: 874  AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDW 933

Query: 700  QEAEVHKLGQRFNNLRQQVERRAQSLQ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755
             + +  +L +R+ N+  Q++ R + L+    S K   + +H   D + Q   +    +  
Sbjct: 934  HKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 993

Query: 756  ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815
            + ++   + T+L  QK L+ EI  ++ ++ +    ++QY   VKDYEL+    R+++D  
Sbjct: 994  QPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-- 1051

Query: 816  NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875
              +     KR R+QS A  + +E   L  ++T +  +     Q ++FA + L++  E E 
Sbjct: 1052 -SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL---MTQYIKFAGDSLKRLEEEEK 1107

Query: 876  THETLQRNRPDSGVE-EAW--KIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESV 932
            + E  ++   +   E + W   I K L +  +  +   ++ K + EEI T + Q      
Sbjct: 1108 SLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQ------ 1161

Query: 933  VRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEY 992
                         L E+ Q +Q  LA  +H +++  EE   L+ Q++ L++         
Sbjct: 1162 -------------LSEALQTIQLFLA--KHGDKMTDEERNELEKQVKTLQE-----SYNL 1201

Query: 993  VVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKV 1052
            +  E L+ +   +Q    +++ E++ A R+Q+          ++++  + +  ++ + ++
Sbjct: 1202 LFSESLK-QLQESQTSGDVKVEEKIVAERQQE---------YKEKLQGICDLLTQTENRL 1251

Query: 1053 TEKEVVKLQNDPQLE-AEYQQLQEDHQRQDQ-----LREKQEEELSFLQDKLKRLEKE-R 1105
               +   +  D  +E  +YQ  QE+ Q+  Q     L E  +   +FL++  ++L +E +
Sbjct: 1252 IGHQEAFMIGDGTVELKKYQSKQEELQKDMQGSAQALAEVVKNTENFLKENGEKLSQEDK 1311

Query: 1106 AMAEGKITVKEV------LKVEKD-AATEREVSDLTRQYEDEAAKARASQREKTELLRKI 1158
            A+ E K+   ++      LK E+     ++ V+   ++  ++ A  +  +  KT++   +
Sbjct: 1312 ALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAAVKQLEESKTKIENLL 1371

Query: 1159 -WA----LEEENA----KVVVQEKVREIVRPDPKA---ESEVANLRLELVEQERKYRGAE 1206
             W      + E A    K V+++        D K+   E +  N  L   + + +    +
Sbjct: 1372 DWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEEDEVNGNLLETDVDGQVGTTQ 1431

Query: 1207 EQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCD 1266
            E L     +++A   +   +  +     +        +EK+ Q L  E  +K +     +
Sbjct: 1432 ENLNQQYQKVKAQHEK---IISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQK----N 1484

Query: 1267 LEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQED--------PQTKEEVASLRAKLSEE 1318
            ++  ++  E    +  K    T  + +E+ +F  D         Q+++E+ +L A   + 
Sbjct: 1485 MKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDI 1544

Query: 1319 QKKQVDLERERASQEEQIARKEE-ELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDV 1377
                  L+R+++  E+ I+ K +     +    V +      +  G + + SA    +  
Sbjct: 1545 NGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQ- 1603

Query: 1378 ELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEA 1437
              R++D      R L  +   L   L++L  + Q   +A   +      LA L+  EA A
Sbjct: 1604 --RKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGL------LAGLQACEATA 1655

Query: 1438 REKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKE 1497
             + ++    V    DP+       L+ QLEE     + L+G++ +   +  A+EK +   
Sbjct: 1656 SKHLSEPIAV----DPKN------LQRQLEE----TKALQGQISS---QQVAVEKLKKTA 1698

Query: 1498 KVVLSE--SVQVEKGDTEQEIQRLKSSLEEESRSKRE----LDVEVSR---LEARLSEL- 1547
            +V+L    S+   K D ++ +  +    E+ S+S  E    L + ++R   ++  L E+ 
Sbjct: 1699 EVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEML 1758

Query: 1548 -EFHNSKSS-KELDFLREENHKLQ-LERQNLQLE--TRRLQSEINMAATETRDLRNMTVA 1602
                N +SS KE   +   +  LQ +  +N+ LE      QS IN    + +     T  
Sbjct: 1759 DWMGNVESSLKEQGQVPLNSTALQDIISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDP 1818

Query: 1603 DSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRL 1640
             + ++  +++  L     +     K+   +++EL+ ++
Sbjct: 1819 STASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKV 1856



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 326/1767 (18%), Positives = 699/1767 (39%), Gaps = 272/1767 (15%)

Query: 16   TVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKV 75
            TV+ +   +K+  EL + +Q +A  + + + +TE  ++ +  +L +    E + +  QK+
Sbjct: 1264 TVELKKYQSKQ-EELQKDMQGSAQALAEVVKNTENFLKENGEKLSQ----EDKALIEQKL 1318

Query: 76   LDSEKLLYVL---------EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRG------- 119
             +++     L         E D  +   +K     + A  ++QL+E  T +         
Sbjct: 1319 NEAKIKCEQLNLKAEQSKKELDKVVTTAIKEETEKVAA--VKQLEESKTKIENLLDWLSN 1376

Query: 120  ----------KHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV---- 165
                      KHKQ+              +A+ EE  D++N     TD   VD QV    
Sbjct: 1377 VDKDSERAGTKHKQVIEQNGTHFQEGDGKSAIGEE--DEVNGNLLETD---VDGQVGTTQ 1431

Query: 166  EEHNIFHNEVKA-----IGPHLA-----------------------KDGDKEQNSELRAK 197
            E  N  + +VKA     I  H A                       K+  ++   EL+  
Sbjct: 1432 ENLNQQYQKVKAQHEKIISQHQAVIIATQSAQVLLEKQGQYLSPEEKEKLQKNMKELKVH 1491

Query: 198  YQKLLAASQARQQHLSSLQDYMQRC----TNELYWLDQQAKGRMQYDWSDRNLDYPSRRR 253
            Y+  LA S+ + +   SLQ+ +++     T   +WL Q  +     +    +++    + 
Sbjct: 1492 YETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGADDINGLMTKL 1551

Query: 254  QYENFINRNLEAKEERINKLHSEGDQLLAAEHP--GRNSIEAHMEAVHADWKEYLNLLI- 310
            + +   + ++ + +  +  +   G+++L A      R+  +    A H + +  L+    
Sbjct: 1552 KRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLDHATD 1611

Query: 311  --------CEE--SHLKYMEDYHQFHEDVK-----DAQELLRKVDSDLNQKYGPDFKD-R 354
                    C    ++LK + D +Q +ED         Q         L++    D K+ +
Sbjct: 1612 RFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKHLSEPIAVDPKNLQ 1671

Query: 355  YQIE---LLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPI-----PVEA 406
             Q+E    L  ++  Q+  ++K +   + L      ++P K   +  L  I      +  
Sbjct: 1672 RQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIVGRYEDLSK 1731

Query: 407  LCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSL 466
              +   E+  I+   S ++Q    E  + M +  + L          P +  AL     +
Sbjct: 1732 SVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQV----PLNSTAL---QDI 1784

Query: 467  GSQYRSVRQKAAGSKRTLQQRYEVLK----TENPGDASDLQGRQLLAGLDKVASDLDRQE 522
             S+   + Q  AG + ++    E +K    T +P  AS LQ +  +  L    S+   + 
Sbjct: 1785 ISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAK--MKDLSARFSEASHKH 1842

Query: 523  KAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGT 582
            K          E    +++   + +  +N++ +L      KT++  E +     +PG   
Sbjct: 1843 K----------ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVD-----VPGKDV 1887

Query: 583  TPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQ----- 637
            T L +   E T+   EH   L  L     ++++     L     L+    N+L++     
Sbjct: 1888 TELSQYMQESTSEFLEHKKHLEVLHSLLKEISSH---GLPSDKALVLEKTNNLSKKFKEM 1944

Query: 638  DDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVE------------QNLQAAKQCSST 685
            +DT+ E    + S  ++L A    +++ KS + E              ++L  + + +  
Sbjct: 1945 EDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKK 2004

Query: 686  LASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAA------------YE 733
            L  ++    P++++    V+  G    NL   V   A+++ + K+              E
Sbjct: 2005 LQEKWSLKTPEIQK----VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTE 2060

Query: 734  HF--HRGHDHVLQFLVSIP-SYEPQET---DSLSQMETKLKNQKNLLDEIASREQEVQKI 787
             F  ++G   + + +  I   YE       D ++++ TKL   +   +E ++  Q +QK+
Sbjct: 2061 EFWANKGLTSIKKDMTDISHGYEDLGLLLKDKIAELNTKLSKLQKAQEESSAMMQWLQKM 2120

Query: 788  CANSQQYQQAVKDYELEAEK--LRSLLDLENGRSSHVSKRARLQSPATKVKEE--EAALA 843
               + ++QQ     + EA K  +      E     +V+K   L+   T++ EE  +   A
Sbjct: 2121 NKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEA 2180

Query: 844  AKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEET 903
             ++ ++      + Q L   L + RQQ   E ++   Q    ++ +++ W + KEL    
Sbjct: 2181 PRWKQMLTEIDSKWQELN-QLTIDRQQKLEESSNNLTQFQTVEAQLKQ-WLVEKELMVSV 2238

Query: 904  ERRRQLENEVKSTQ--------EEIWTLRNQGPQESVVRKEVLKKV-PDPVLEESFQQLQ 954
                 ++  + +TQ        +E  T + Q  Q +   + +L +   DP L    ++  
Sbjct: 2239 LGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPSLRGIVKEQL 2298

Query: 955  RTLAEE---------QHKNQLLQEELEALQLQ--LRALEQETRDGGQEYVVKEVLRIEPD 1003
              + ++            + + Q  +++ Q Q  LR+L  +  D   +      +   PD
Sbjct: 2299 AAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPD 2358

Query: 1004 --RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQ 1061
                Q +   ++++E++  ++Q    +A   L +   A + EE  +A+     + ++K  
Sbjct: 2359 AMNQQLETAQKMKQEIQQEKKQIKVAQA---LCEDLSALVKEEYLKAELSRQLEGILKSF 2415

Query: 1062 NDPQLEAE--YQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLK 1119
             D + +AE   Q LQ       Q ++   +  ++L  K +   K   ++     ++ ++K
Sbjct: 2416 KDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIK 2475

Query: 1120 VEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVR 1179
              KD +  + ++  +  YE   A       E   LL K    E    K  +Q ++  I  
Sbjct: 2476 DHKDFS--KTLTAQSHMYEKTIA-------EGENLLLKTQGSE----KAALQLQLNTI-- 2520

Query: 1180 PDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYK 1239
               K   +  N +++  E+E K + + E+   Y+ ++E L    P ++  +   E IK+ 
Sbjct: 2521 ---KTNWDTFNKQVK--ERENKLKESLEKALKYKEQVETL---WPWIDKCQNNLEEIKFC 2572

Query: 1240 TDPEMEK----ELQRLREEIVDKTRLIERCD------LEIYQLKKEIQALKDTKPQVQTK 1289
             DP   +    +L+ L++E+     ++E  +      L + ++ KE+    + K  +Q  
Sbjct: 2573 LDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEV-VTDENKSLIQKV 2631

Query: 1290 EVVQEILQFQE-DPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQI---ARKEEELSR 1345
            ++V E L  ++   +   +      ++S+E K+Q+   +E+    + +   A   + L+ 
Sbjct: 2632 DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTM 2691

Query: 1346 VKERVVQQEVVRYEEEPGLRAEASAFAESIDVE-----LRQIDKLRAELRRLQRRRTE-- 1398
            ++ +    + ++++ +   R       E+ D +     L Q++ +  E   L ++  E  
Sbjct: 2692 LQTQQKSLQALKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVETIAQEHSTLSQQVDEKC 2751

Query: 1399 --LERQLEELERERQARREAEREVQRLQQRLAALEQ--EEAEAREKVTHTQKVVLQQ--- 1451
              LE +L+ +   +   RE   +       L ++     +AE  +K   T K  L++   
Sbjct: 2752 SFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEA 2811

Query: 1452 ---DPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKL-AALEKAEVKEKVVLSESVQV 1507
                   A +   + L  EE       ++ +LE L ++    L++A+ +E+ V     ++
Sbjct: 2812 LMASNDNANKTCKMMLATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRL 2871

Query: 1508 EKGDTE-QEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566
            E+  ++ +E   L    EE   S+  + +E   +  +L+  +           F +EE  
Sbjct: 2872 EEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKV----------FQKEEIE 2921

Query: 1567 KLQLERQNLQ-LETRRLQSEINMAATE 1592
             LQ ++Q++  L    +QS     +T+
Sbjct: 2922 PLQGKQQDVNWLGQGLIQSAAKSTSTQ 2948



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 170/848 (20%), Positives = 339/848 (39%), Gaps = 150/848 (17%)

Query: 570  GEAFIQALPGSGTTPLLRTRVEDTNRKYEHL----LQLLDLAQEKVDVANRLEKSLQQ-- 623
            G+  IQ+   S +T  L   ++D N +++ L     Q     QE +    R + +L+   
Sbjct: 2934 GQGLIQSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLL 2993

Query: 624  SWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQK---SLLGEVEQNLQAAK 680
            SW ++ T E   NQ    P S+        E   +  ++Q QK    LL + +  ++  K
Sbjct: 2994 SW-MVDTEELVANQK---PPSA--------EFKVVKAQIQEQKLLQRLLDDRKSTVEVIK 3041

Query: 681  QCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHD 740
            +    +A+  +    D  +   ++  L  R+  L  + E R + L+      + FH   +
Sbjct: 3042 REGEKIATTAEP--ADKVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLE 3099

Query: 741  HVLQFLVSIP----SYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQ 796
             + ++L +I     + EP  T + S++E ++   K L D+I +  + + +  +  Q  + 
Sbjct: 3100 PLNEWLTTIEKRLVNCEPIGTQA-SKLEEQIAQHKALEDDIINHNKHLHQAVSIGQSLK- 3157

Query: 797  AVKDYELEAEKLRSLLD------LENGRSSHVSKRARLQSPATKVK---EEEAALAAKFT 847
             V     + + ++S LD      +E    SH S+   LQ      K   E+E  L     
Sbjct: 3158 -VLSSREDKDMVQSKLDFSQVWYIEIQEKSH-SRSELLQQALCNAKIFGEDEVELMNWLN 3215

Query: 848  EVY-AINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPD------SGVE---------- 890
            EV+  +++  +Q+      L +QQ E+ V  E +   + +      +G+E          
Sbjct: 3216 EVHDKLSKLSVQDYSTE-GLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEV 3274

Query: 891  ---------------EAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRK 935
                           +  K+  ++ +  E+  QL   + ST EE+ T  ++      V  
Sbjct: 3275 LIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK------VEV 3328

Query: 936  EVLKKVPDPVLEESFQQLQ---RTLAEEQHKNQLLQEEL-EALQLQLRALEQETRDGGQE 991
            E+L      +  E   Q Q   + L +E   N+ L + L E     L  +    R+G ++
Sbjct: 3329 ELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREGLEK 3388

Query: 992  YVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEK 1051
             V ++  R    R  +D + Q  EE++A           +L  QQ   A   E S   E 
Sbjct: 3389 MVAEDNERY---RLVSDTITQKVEEIDAA----------ILRSQQFDQAADAELSWITE- 3434

Query: 1052 VTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGK 1111
             TEK+++ L  D +LE            QDQ   + + + +F  + L+  +    + +  
Sbjct: 3435 -TEKKLMSL-GDIRLE------------QDQTSAQLQVQKTFTMEILRHKDIIDDLVKSG 3480

Query: 1112 ITVKEVLKVEKDAATEREVSDLTRQYED--EAAKARASQREKTE-LLRKIWALEEENAKV 1168
              +      E+  + ++++  + + Y+   +    R  Q E+ + L+ + W   EE    
Sbjct: 3481 HKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVNQFWETYEELWPW 3540

Query: 1169 VVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQ--- 1225
            + + +      P P  E E       L +Q+ ++R   E +  ++  ++ + + GPQ   
Sbjct: 3541 LTETQSIISQLPAPALEYET------LRQQQEEHRQLRELIAEHKPHIDKMNKTGPQLLE 3594

Query: 1226 --------VEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQ 1277
                    ++ K V  + +  +   +++K    L E I   T+  ++ D  +  L++ ++
Sbjct: 3595 LSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILESLERIVE 3654

Query: 1278 ALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIA 1337
             L+                   + P    EV  ++ ++SE +   VD+E+ +   E    
Sbjct: 3655 RLR-------------------QPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQ 3695

Query: 1338 RKEEELSR 1345
            R EE ++R
Sbjct: 3696 RGEEMIAR 3703



 Score = 71.2 bits (173), Expect = 8e-12
 Identities = 264/1303 (20%), Positives = 495/1303 (37%), Gaps = 209/1303 (16%)

Query: 455  TDPEALALADSLGSQYRSVRQKAAGSKRTLQQ-RYEVLKTENPGDASDLQGRQLLAGLDK 513
            T P+ L L+   G    S+++K   +     Q + +V K     D +  Q  Q    +D+
Sbjct: 3588 TGPQLLELSPGEGF---SIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQ 3644

Query: 514  VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573
            +   L+R    I   LR P      V+   E+  + KN++ ++ +++P        GE  
Sbjct: 3645 ILESLER----IVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 3700

Query: 574  IQALPGSG---TTPLLRTRVEDTNRKYEHLLQLLDLAQEK-VDVANRLEKSLQQSWELLA 629
            I    G+    +   ++ +++     +E++  L++  + K +DV    EK       L+ 
Sbjct: 3701 IARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIV 3760

Query: 630  THENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASR 689
            T ++         +  R L+  G + + +  + +A +++  E++  LQ        L S 
Sbjct: 3761 TIKD-------TQDFIRDLEDPGIDPSVVKQQQEAAETIREEID-GLQEELDIVINLGSE 3812

Query: 690  FQEHC--PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLV 747
                C  PD    +  + +L   +++L +  + R   L+ A  A   +  G    LQ + 
Sbjct: 3813 LIAACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDG----LQAVF 3868

Query: 748  SIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEK 807
                    +  S+S + T L+  K  ++E+             S+ YQQ     ++E E+
Sbjct: 3869 DWVDIAGGKLASMSPIGTDLETVKQQIEELKQ---------FKSEAYQQ-----QIEMER 3914

Query: 808  LRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLL 867
            L    +L   + +  S +  +Q P  ++K     L     E   INRQ    LE AL  L
Sbjct: 3915 LNHQAELLLKKVTEESDKHTVQDPLMELK-----LIWDSLEERIINRQ--HKLEGALLAL 3967

Query: 868  RQQPE--------VEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEE 919
             Q           +  T   L   +P  G  +A +I      E  +   L+N+V + Q  
Sbjct: 3968 GQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEI------ELAKHHVLQNDVLAHQST 4021

Query: 920  IWTLRNQGPQ--ESVVRKEVLKKVPDPVLEESFQQLQRTLAE-EQHKNQL---------L 967
            +  +   G    ES   +E         LE   Q+ Q  L + EQ K QL          
Sbjct: 4022 VEAVNKAGNDLIESSAGEEASNL--QNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGF 4079

Query: 968  QEELEALQLQLRALEQETRD----GGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQ 1023
              E+E LQ  L   E+        GG     KE L +  +   A E    +EE      Q
Sbjct: 4080 HGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEA---KEETYKSLMQ 4136

Query: 1024 KGAR------EAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDH 1077
            KG +      ++    + Q +  L E+    + K+ E++  KL+    L  E+    +D 
Sbjct: 4137 KGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERK-TKLEEALNLAMEFHNSLQDF 4195

Query: 1078 -----QRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSD 1132
                 Q +  L       L  L   L +++      E K+   EV    ++   E + + 
Sbjct: 4196 INWLTQAEQTLNVASRPSL-ILDTVLFQID------EHKVFANEV-NSHREQIIELDKTG 4247

Query: 1133 LTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVR-----EIVRPDPKAESE 1187
               +Y         SQ++   L++ +    +   + VVQ  V      +  R   K   E
Sbjct: 4248 THLKY--------FSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHE 4299

Query: 1188 VANLRLELVEQERKYRGAE-----------EQLRSYQSELEALRRRGPQVEVKEVTKEVI 1236
              +  +E +E+  K   +E            QL  ++   ++L  +    +    T   +
Sbjct: 4300 AWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKEFQKSLGAKHSVYDTTNRTGRSL 4359

Query: 1237 KYKT-----DPEMEKELQRLRE-------EIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284
            K KT     + +++  L  LR+       + V++   +E   L   Q    +QAL D   
Sbjct: 4360 KEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLY 4419

Query: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344
            +V+ +    + +    D      + + +A   E  K+   ++  + S  E I    ++ S
Sbjct: 4420 RVEPQLAEDQPVHGDID-LVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSS 4478

Query: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
             VK + +Q+   R+E    L          ++  LRQ ++  + +  L     E E+ L 
Sbjct: 4479 WVKVQ-MQELSTRWETVCALSISKQT---RLEAALRQAEEFHSVVHALLEWLAEAEQTLR 4534

Query: 1405 ---ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVT--HTQKVVLQQDPQQAREH 1459
                L  +  A R     + + ++ +  LE++ AE  +  T   T   +   D     +H
Sbjct: 4535 FHGVLPDDEDALRTL---IDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKH 4591

Query: 1460 --ALLRLQLEE-----EQHRRQL------LEGELETLRRKLAALEKAEV----KEKVVLS 1502
               ++R + EE     +QH+++L      L  + E L   LA L+ AE     K+K V+ 
Sbjct: 4592 WITIIRARFEEVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIP 4651

Query: 1503 ESVQ------VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSK 1556
            + ++       E     +E+ R +  +++ +++ +    + S L++ +  L+   +   +
Sbjct: 4652 QEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKR 4711

Query: 1557 -ELDFLREENHKLQLERQN---------------LQLETRRLQSEINMAATETRDLRNMT 1600
                 L     + Q+E +N               L LE RR   ++N A     +LR   
Sbjct: 4712 FPASSLYPSGSQTQIETKNPRVNLLVSKWQQVWLLALERRR---KLNDALDRLEELREF- 4767

Query: 1601 VADSGTNHDSRLW----------SLERELDDLKRLSKDKDLEI 1633
                  N D  +W             R +D  +R+ KD+D +I
Sbjct: 4768 -----ANFDFDIWRKKYMRWMNHKKSRVMDFFRRIDKDQDGKI 4805



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 250/1287 (19%), Positives = 495/1287 (38%), Gaps = 203/1287 (15%)

Query: 454  PTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDK 513
            PTD EA+         + +  ++     + L+ +   L  ENP      + +Q+L  +D 
Sbjct: 2133 PTDTEAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDS 2192

Query: 514  VASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAF 573
               +L++                    D  ++ ++  N   +   +E +  +   E E  
Sbjct: 2193 KWQELNQ-----------------LTIDRQQKLEESSNNLTQFQTVEAQLKQWLVEKELM 2235

Query: 574  IQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHEN 633
            +  L      P     + +T R+   +L L + A  K            Q  +L A  + 
Sbjct: 2236 VSVLGPLSIDP----NMLNTQRQQVQIL-LQEFATRK-----------PQYEQLTAAGQG 2279

Query: 634  HLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGE-------VEQNLQAAKQCSSTL 686
             L++    P    ++    ++LAA+    Q   SL G+       ++Q +  + Q  S L
Sbjct: 2280 ILSRPGEDPSLRGIVK---EQLAAVT---QKWDSLTGQLSDRCDWIDQAIVKSTQYQSLL 2333

Query: 687  ASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFL 746
             S   +   DL+ + +    +    + + QQ+E   +  Q  +   +   +    + + L
Sbjct: 2334 RS-LSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQI-KVAQALCEDL 2391

Query: 747  VSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYE--LE 804
             ++   E  + +   Q+E  LK+ K++  +  +  Q +Q  CA+S Q+QQ  +D++  L+
Sbjct: 2392 SALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLD 2451

Query: 805  AEK---------------LRSLLDLENGRS------SHVSKRARLQSPATKVK---EEEA 840
             +K               L SL+      S      SH+ ++   +     +K    E+A
Sbjct: 2452 TKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLLLKTQGSEKA 2511

Query: 841  ALAAKFTEVY----AINRQ-------RLQNLEFALNLLRQ-----------QPEVEVTHE 878
            AL  +   +       N+Q         ++LE AL    Q           Q  +E    
Sbjct: 2512 ALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF 2571

Query: 879  TLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKS------TQEEIWTLRNQGPQESV 932
             L     ++ + +   ++KE+D+       L N   S        +E+ T  N       
Sbjct: 2572 CLDPAEGENSIAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDEN------- 2624

Query: 933  VRKEVLKKVPDPVLEESFQQ---LQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGG 989
              K +++KV D V E+   +   L+    + +   ++ +E    LQ     L+     G 
Sbjct: 2625 --KSLIQKV-DMVTEQLHSKKFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGS 2681

Query: 990  QEYVVKEVLRIEPD-------RAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALA 1042
            Q Y  K +  ++         + Q D   +L ++L  +        ++VLL   +V  +A
Sbjct: 2682 QAYSNKYLTMLQTQQKSLQALKHQVDLAKRLAQDL-VVEASDSKGTSDVLL---QVETIA 2737

Query: 1043 EEKSRAQEKVTEK---EVVKLQN----DPQLEAEYQQLQEDHQRQDQLR---------EK 1086
            +E S   ++V EK      KLQ        +   + Q  E     D +          +K
Sbjct: 2738 QEHSTLSQQVDEKCSFLETKLQGIGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQK 2797

Query: 1087 QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDA----ATEREVSDLTRQYED--E 1140
            Q+E +     KL+ L      A    T K +L  E+ +      +R++  L++Q     +
Sbjct: 2798 QKETIKAFLKKLEALMASNDNANK--TCKMMLATEETSPDLVGIKRDLEALSKQCNKLLD 2855

Query: 1141 AAKARASQREKT-ELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQE 1199
             A+AR  Q E T + L + ++  +E + ++ + +  E  +     E+E  N +L + +  
Sbjct: 2856 RAQAREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVF 2915

Query: 1200 RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKT 1259
            +K     E L+  Q ++  L +   Q   K  + + +++  D ++    + L +++  + 
Sbjct: 2916 QKEE--IEPLQGKQQDVNWLGQGLIQSAAKSTSTQGLEHDLD-DVNARWKTLNKKVAQRA 2972

Query: 1260 RLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQ 1319
              ++   L   + +  +++L      V T+E+V      Q+ P  + +V   +    +EQ
Sbjct: 2973 AQLQEALLHCGRFQDALESLLSW--MVDTEELVAN----QKPPSAEFKVVKAQI---QEQ 3023

Query: 1320 KKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVEL 1379
            K    L  +R S  E I R+ E+++   E   + ++                       L
Sbjct: 3024 KLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVKI-----------------------L 3060

Query: 1380 RQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEARE 1439
            +Q+  L +    L  +     RQLE +    Q   E    ++ L + L  +E+       
Sbjct: 3061 KQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHET---LEPLNEWLTTIEKRLVNCEP 3117

Query: 1440 KVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKV 1499
              T   K+    + Q A+  AL    +   +H  Q +    ++L+   +  +K  V+ K+
Sbjct: 3118 IGTQASKL----EEQIAQHKALEDDIINHNKHLHQAVSIG-QSLKVLSSREDKDMVQSKL 3172

Query: 1500 VLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVS-RLEARLSELEFHNSKSSKEL 1558
              S+   +E     QE    +S L +++    ++  E    L   L+E+    SK S + 
Sbjct: 3173 DFSQVWYIE----IQEKSHSRSELLQQALCNAKIFGEDEVELMNWLNEVHDKLSKLSVQ- 3227

Query: 1559 DFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERE 1618
            D+  E   K Q E + LQ +    +  ++ A     +L   T  D       +L +++  
Sbjct: 3228 DYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKAR 3287

Query: 1619 LDDLKRLSKD--KDLE-IDELQKRLGS 1642
              D+ +LS D  K LE   +L +RL S
Sbjct: 3288 YKDITKLSTDVAKTLEQALQLARRLHS 3314



 Score = 64.3 bits (155), Expect = 1e-09
 Identities = 211/1170 (18%), Positives = 466/1170 (39%), Gaps = 171/1170 (14%)

Query: 585  LLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPES 644
            +++ ++E    +Y+      D+ +   DVA  LE++LQ +  L +THE      D V   
Sbjct: 3276 IIQDKLEAIKARYK------DITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVE 3329

Query: 645  SRVLDS---KGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQ- 700
                ++   KG+E    A + Q +   L +  +N +A     + ++S   E  P   R+ 
Sbjct: 3330 LLSYETQVLKGEE----ASQAQMRPKELKKEAKNNKALLDSLNEVSSALLELVPWRAREG 3385

Query: 701  -EAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQF-------LVSIPSY 752
             E  V +  +R+  +   + ++ + + +A    + F +  D  L +       L+S+   
Sbjct: 3386 LEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDI 3445

Query: 753  EPQETDSLSQMET------KLKNQKNLLDEIASREQEVQKICANSQ------QYQQAVKD 800
              ++  + +Q++       ++   K+++D++     ++   C+  +      +  + +K+
Sbjct: 3446 RLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKN 3505

Query: 801  Y----ELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQR 856
            Y    ++ +E+   L   ++  +        L    T+ +   + L A   E   + +Q+
Sbjct: 3506 YDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQ 3565

Query: 857  LQNLEFALNLLRQQPEVEVTHET---LQRNRPDSG--VEEAW----KIRKELDEETERRR 907
             ++ +    +   +P ++  ++T   L    P  G  ++E +     +  ++ E+ ++R 
Sbjct: 3566 EEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRA 3625

Query: 908  QLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLL 967
               +E  S   +     +Q   ES+ R  +++++  P    S       + E+  +N+ +
Sbjct: 3626 VALDEAISQSTQFHDKIDQ-ILESLER--IVERLRQP---PSISAEVEKIKEQISENKNV 3679

Query: 968  QEELEALQ-----LQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRR 1022
              ++E LQ     L+ R  E   R GG +    + +  +  + + D+++ + E +  L  
Sbjct: 3680 SVDMEKLQPLYETLKQRGEEMIARSGGTD----KDISAKAVQDKLDQMVFIWENIHTLVE 3735

Query: 1023 QKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQ 1082
            ++ A+  +V+ L ++     +  S        ++ ++   DP ++          ++Q +
Sbjct: 3736 EREAKLLDVMELAEKF--WCDHMSLIVTIKDTQDFIRDLEDPGIDPSVV------KQQQE 3787

Query: 1083 LREKQEEELSFLQDKLK---RLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYED 1139
              E   EE+  LQ++L     L  E   A G          E D    ++  D      D
Sbjct: 3788 AAETIREEIDGLQEELDIVINLGSELIAACG----------EPDKPIVKKSIDELNSAWD 3837

Query: 1140 EAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLR-----LE 1194
               KA   + +K E        E   A V  Q+ ++ +      A  ++A++      LE
Sbjct: 3838 SLNKAWKDRIDKLE--------EAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE 3889

Query: 1195 LVEQE-RKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKT-DPEMEKEL--QR 1250
             V+Q+  + +  + +    Q E+E L  +  ++ +K+VT+E  K+   DP ME +L    
Sbjct: 3890 TVKQQIEELKQFKSEAYQQQIEMERLNHQA-ELLLKKVTEESDKHTVQDPLMELKLIWDS 3948

Query: 1251 LREEIVDKTRLIERCDLEIYQLKKEIQ-----------ALKDTKPQVQTKEVVQEILQFQ 1299
            L E I+++   +E   L + Q +  +             L + KP     + ++  ++  
Sbjct: 3949 LEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE--IELA 4006

Query: 1300 EDPQTKEEVASLRAKLSEEQKKQVDLERERASQE-EQIARKEEELSRVKERVVQQEVVRY 1358
            +    + +V + ++ +    K   DL    A +E   +  K E L++  + V+++   R 
Sbjct: 4007 KHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRK 4066

Query: 1359 EEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAER 1418
            ++              +D  LRQ      E+  LQ+  T+ ER L   +        A+ 
Sbjct: 4067 QQ--------------LDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKE 4112

Query: 1419 EVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEG 1478
            ++    +  AA E +E         T K ++Q+  Q      L R     E +    ++ 
Sbjct: 4113 QLNVHMEVCAAFEAKE--------ETYKSLMQKGQQM-----LARCPKSAETN----IDQ 4155

Query: 1479 ELETLRRKLAALE------KAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRE 1532
            ++  L+ K  ++E      K +++E + L+        D    + + + +L   SR    
Sbjct: 4156 DINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLI 4215

Query: 1533 LDVEVSRLEAR---LSELEFHN------SKSSKELDFLREENHKLQLERQNLQLETRRLQ 1583
            LD  + +++      +E+  H        K+   L +  ++   + +  +NL +  +   
Sbjct: 4216 LDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLI--KNLLISVQSRW 4273

Query: 1584 SEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEI----DELQKR 1639
             ++     E    R++  A          WS   E  +    S D +LEI    D+++ +
Sbjct: 4274 EKVVQRLVERG--RSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQ 4331

Query: 1640 LGSVAVKREQRENHLRRSIVVIHPDTGREL 1669
            L     K  Q+    + S+      TGR L
Sbjct: 4332 LAQ--HKEFQKSLGAKHSVYDTTNRTGRSL 4359



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 196/1134 (17%), Positives = 447/1134 (39%), Gaps = 143/1134 (12%)

Query: 599  HLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAM 658
            H    L  +++K+ + + L++ L++        E+ L Q +   E+   L++   ++  +
Sbjct: 1491 HYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELEN---LEAGADDINGL 1547

Query: 659  ACELQAQKSLLGEVEQN--------------LQAAKQCSSTLASRFQEHCPDLERQEAEV 704
              +L+ QKS   +V  +              L+AAK CS     +        E Q    
Sbjct: 1548 MTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAKSCSKRDGGKVDTSATHREVQRKLD 1607

Query: 705  HKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQ-- 762
            H    RF +L  +      +L+     Y+H+    D     L  + + E   +  LS+  
Sbjct: 1608 HAT-DRFRSLYSKCNVLGNNLKDLVDKYQHYE---DASCGLLAGLQACEATASKHLSEPI 1663

Query: 763  ------METKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLEN 816
                  ++ +L+  K L  +I+S++  V+K+   ++    A          ++  LD   
Sbjct: 1664 AVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKTLDDIV 1723

Query: 817  GRSSHVSKRA-----RLQSPATKVKEEEAAL------------AAKFTEVYAINRQRLQ- 858
            GR   +SK       +LQ   T+    +  L            + K      +N   LQ 
Sbjct: 1724 GRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGNVESSLKEQGQVPLNSTALQD 1783

Query: 859  ----NLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVK 914
                N+    ++  +Q  +   +E +++    +    A  ++ ++ + + R  +  ++ K
Sbjct: 1784 IISKNIMLEQDIAGRQSSINAMNEKVKKFMETTDPSTASSLQAKMKDLSARFSEASHKHK 1843

Query: 915  STQEEIWTLRN------------QGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEE-Q 961
             T  ++  L+             Q   E+  +      VP   + E  Q +Q + +E  +
Sbjct: 1844 ETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTELSQYMQESTSEFLE 1903

Query: 962  HKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPD-RAQADEVLQLREELEAL 1020
            HK     + LE L   L+ +        +  V+++   +    +   D + + +E + + 
Sbjct: 1904 HK-----KHLEVLHSLLKEISSHGLPSDKALVLEKTNNLSKKFKEMEDTIKEKKEAVTSC 1958

Query: 1021 RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVK-LQNDPQLEAEYQQLQEDHQR 1079
            + Q  A +  V  L+  +    ++    Q     +++ K L++  +L+ ++     + Q+
Sbjct: 1959 QEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAEDLGKSLEDTKKLQEKWSLKTPEIQK 2018

Query: 1080 QDQLREKQEEELSFLQDKLKRLEKERA-----MAEGKITVKEVLKVEKDAAT-EREVSDL 1133
             +         +S +    K +   ++       EG  T  E     K   + +++++D+
Sbjct: 2019 VNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNGEGTATNTEEFWANKGLTSIKKDMTDI 2078

Query: 1134 TRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRL 1193
            +  YED     +    E    L K+   +EE++   + + ++++ +   K +   A    
Sbjct: 2079 SHGYEDLGLLLKDKIAELNTKLSKLQKAQEESS--AMMQWLQKMNKTATKWQQTPAPTDT 2136

Query: 1194 ELVE-QERKYRGAEEQLRSYQSELEALRRRGPQ-VEVKEVTKEVIKYKTD-PEMEKELQR 1250
            E V+ Q  + +  E +L+   ++++ L+ +  + +E    T E  ++K    E++ + Q 
Sbjct: 2137 EAVKTQVEQNKSFEAELKQNVNKVQELKDKLTELLEENPDTPEAPRWKQMLTEIDSKWQE 2196

Query: 1251 LREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDP-QTKEEVA 1309
            L +  +D+ + +E     + Q +     LK     V+ + +V  +     DP     +  
Sbjct: 2197 LNQLTIDRQQKLEESSNNLTQFQTVEAQLKQW--LVEKELMVSVLGPLSIDPNMLNTQRQ 2254

Query: 1310 SLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEAS 1369
             ++  L E   ++   E+  A+ +  ++R  E+ S ++  V +Q     ++   L  + S
Sbjct: 2255 QVQILLQEFATRKPQYEQLTAAGQGILSRPGEDPS-LRGIVKEQLAAVTQKWDSLTGQLS 2313

Query: 1370 AFAESIDVELRQIDKLRAELRRLQRRRTELERQL--------------EELERERQARRE 1415
               + ID  + +  + ++ LR L  + ++L+ +L              ++LE  ++ ++E
Sbjct: 2314 DRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQKMKQE 2373

Query: 1416 AERE------VQRLQQRLAALEQE---------------------EAEAREKVTHTQKVV 1448
             ++E       Q L + L+AL +E                     E +A   V H Q   
Sbjct: 2374 IQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQHLQSAC 2433

Query: 1449 L--QQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQ 1506
                Q  Q +R+        +EEQ++   +  +L+ L    + ++  +   K + ++S  
Sbjct: 2434 ASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLE---SLIKDHKDFSKTLTAQSHM 2490

Query: 1507 VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENH 1566
             EK   E E   LK+   E++  + +L+   +  +    +++   +K  + L+  +   +
Sbjct: 2491 YEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLE--KALKY 2548

Query: 1567 KLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELD 1620
            K Q+E          L   I+       +++       G N  ++L SL++E+D
Sbjct: 2549 KEQVE---------TLWPWIDKCQNNLEEIKFCLDPAEGENSIAKLKSLQKEMD 2593



 Score = 35.4 bits (80), Expect = 0.49
 Identities = 67/320 (20%), Positives = 133/320 (41%), Gaps = 57/320 (17%)

Query: 26   ELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVL 85
            +L E +E+ +K+ D  E  I +   K+++ LA+ +E           QK L ++  +Y  
Sbjct: 4303 KLMEWLEESEKSLDS-ELEIANDPDKIKTQLAQHKE----------FQKSLGAKHSVY-- 4349

Query: 86   EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKE-------------- 131
              D          +   +A+D  +L + ++ LR K   I   +V+               
Sbjct: 4350 --DTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQF 4407

Query: 132  ---VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNE-------VKAIGPH 181
               +   ++W   VE +L +  +Q    D+ LV + ++ H  F  E       V+A+   
Sbjct: 4408 TDALQALIDWLYRVEPQLAE--DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRS 4465

Query: 182  LAK--DGDKEQNS-------ELRAKYQKLLAASQARQQHLSSL----QDYMQRCTNELYW 228
              +  +G ++ +S       EL  +++ + A S ++Q  L +     +++       L W
Sbjct: 4466 ARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEW 4525

Query: 229  LDQQAKG-RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPG 287
            L +  +  R      D      +   Q++ F+ + LE K   +NK  + GD +LA  HP 
Sbjct: 4526 LAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKK-LEEKRAELNKATTMGDTVLAICHPD 4584

Query: 288  R-NSIEAHMEAVHADWKEYL 306
               +I+  +  + A ++E L
Sbjct: 4585 SITTIKHWITIIRARFEEVL 4604



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 70/347 (20%), Positives = 138/347 (39%), Gaps = 43/347 (12%)

Query: 110  LKERVTNLRGKHKQIYRLAVKE----VDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQV 165
            L+ER+ N + K +    LA+ +    +D  + W    E  L +   +  G D   ++ ++
Sbjct: 3949 LEERIINRQHKLEGAL-LALGQFQHALDELLAWLTHTEGLLSE--QKPVGGDPKAIEIEL 4005

Query: 166  EEHNIFHNEVKA----------IGPHLAKDGDKEQNSELRAK-------YQKLLAASQAR 208
             +H++  N+V A           G  L +    E+ S L+ K       +Q +L  ++ R
Sbjct: 4006 AKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQR 4065

Query: 209  QQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLD-YPSRRRQYENF---INRNLE 264
            +Q L       +    E+  L Q      ++  + + L   P   ++  N    +    E
Sbjct: 4066 KQQLDGALRQAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFE 4125

Query: 265  AKEERINKLHSEGDQLLA-AEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYH 323
            AKEE    L  +G Q+LA        +I+  +  +   W+     L   E   K  E  +
Sbjct: 4126 AKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKL--NERKTKLEEALN 4183

Query: 324  ---QFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQE---KVLDKYEDV 377
               +FH  ++D    L + +  LN    P       ++ +L ++D+ +     ++ + + 
Sbjct: 4184 LAMEFHNSLQDFINWLTQAEQTLNVASRPSL----ILDTVLFQIDEHKVFANEVNSHREQ 4239

Query: 378  VQGLQKRGQQVVPLKYRRETPL-KPIPVEALCDFEG-EQGLISRGYS 422
            +  L K G  +     +++  L K + +     +E   Q L+ RG S
Sbjct: 4240 IIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRS 4286



 Score = 31.6 bits (70), Expect = 7.1
 Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 12/85 (14%)

Query: 103  IAEDIRQLKER-------VTNLRGKHKQIYRLAVK---EVDPQVNWAALVEEKLDKLNNQ 152
            I +DI  LKE+       +   + K ++   LA++    +   +NW    E+ L+  +  
Sbjct: 4153 IDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRP 4212

Query: 153  SFGTDLPLVDHQVEEHNIFHNEVKA 177
            S   D  L   Q++EH +F NEV +
Sbjct: 4213 SLILDTVLF--QIDEHKVFANEVNS 4235


>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
          Length = 3062

 Score =  283 bits (723), Expect = 1e-75
 Identities = 227/944 (24%), Positives = 435/944 (46%), Gaps = 108/944 (11%)

Query: 129  VKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHL--AKDG 186
            +K V   +NW   V+E   +L+   +G+DLP V+  +E H   H  ++     L  AK  
Sbjct: 279  MKFVQDLLNW---VDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKIS 335

Query: 187  DKEQNSELR-----------AKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKG 235
            + +  + L+           ++Y KLL  S+ +++HL +L +++ R TNEL WL+++ + 
Sbjct: 336  EIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEEE 395

Query: 236  RMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHM 295
             + YDWS+RN +  +R++ Y   + R L+ KEE I  +    +QLL   HP R +IEA+ 
Sbjct: 396  EVAYDWSERNTNI-ARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 296  EAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDR- 354
             A+   W   L L  C E H+K    Y +F  D K+A + LR +   + +KY  D     
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 355  YQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRR-ETPLK-PIPVEALCDFEG 412
            +++E L++E  ++++ L +Y+  +  L  + + ++ LK R  + PLK  IP++A+CD+  
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 413  EQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR 471
             +  I +     L  N+  + W+++   GN+ + P+VCF +PP + EA+ LA+ +  QY+
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 472  SV----RQKAAGSKRTLQQRYEV-------------LKTENPGD----ASDLQGR----- 505
            +V     +     K  +   Y +             +KT  PG+     S+LQ R     
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 506  ------QLLAGLDKV------------------ASDLDRQEKAITGI------------- 528
                  Q+ +G D                    +++ + QE+++  +             
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754

Query: 529  ---------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579
                     +R PLE+   + +S  R  + + +  EL R++ +    T + E F      
Sbjct: 755  NCEDRLIRQIRTPLERD-DLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAA 813

Query: 580  SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDD 639
            S + P LR+ +    +    +  +     +K+   N + K+ Q +  L+  +E  L +++
Sbjct: 814  SSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEE 873

Query: 640  TVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLER 699
             V      +++    L     E+  ++ +   +E  LQ AK  S  +   ++E   D + 
Sbjct: 874  AVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDW 933

Query: 700  QEAEVHKLGQRFNNLRQQVERRAQSLQ----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQ 755
             + +  +L +R+ N+  Q++ R + L+    S K   + +H   D + Q   +    +  
Sbjct: 934  HKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQEN 993

Query: 756  ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815
            + ++   + T+L  QK L+ EI  ++ ++ +    ++QY   VKDYEL+    R+++D  
Sbjct: 994  QPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVD-- 1051

Query: 816  NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875
              +     KR R+QS A  + +E   L  ++T +  +     Q ++FA + L++  E E 
Sbjct: 1052 -SQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTL---MTQYIKFAGDSLKRLEEEEK 1107

Query: 876  THETLQRNRPDSGVE-EAW--KIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESV 932
            + E  ++   +   E + W   I K L +  +  +   ++ K + EEI T + Q  +   
Sbjct: 1108 SLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167

Query: 933  VRKEVLKKVPDPVLEESFQQLQRTLAEEQHK-NQLLQEELEALQ 975
              +  L K  D + +E   +L++ +   Q   N L  E L+ LQ
Sbjct: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQ 1211



 Score = 55.1 bits (131), Expect = 6e-07
 Identities = 200/1033 (19%), Positives = 396/1033 (38%), Gaps = 181/1033 (17%)

Query: 760  LSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVK-DYELEAEKLRS----LLDL 814
            L  +E+ L+N KN+   I   E  +++   +  Q    +K  Y  +  +L S    LL+ 
Sbjct: 305  LPSVESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNT 364

Query: 815  ENGRSSHVSKRARLQSPATKV-----KEEEAALAAKFTEVYA-INRQRLQNLEFALNLLR 868
               +  H+       S AT       ++EE  +A  ++E    I R++  + E    L +
Sbjct: 365  SRNQERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQ 424

Query: 869  QQPEV----EVTHETLQRNRPDSGVEEAWKIRKELD---------------EETERRRQL 909
            ++  +    E+  + L  N P     EA++   +                 +E     + 
Sbjct: 425  KEENIKSVQEIAEQLLLENHPARLTIEAYRAAMQTQWSWILQLCQCVEQHIKENTAYFEF 484

Query: 910  ENEVKSTQEEIWTLRNQGPQE-SVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQ 968
             N+ K   + +  L++   ++ S  R   + K+ D +++ES ++          K +LLQ
Sbjct: 485  FNDAKEATDYLRNLKDAIQRKYSCDRSSSIHKLED-LVQESMEE----------KEELLQ 533

Query: 969  EELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGARE 1028
             +     L  +A              K +++++P    +D  L+    ++A+      R+
Sbjct: 534  YKSTIANLMGKA--------------KTIIQLKP--RNSDCPLKTSIPIKAICDY---RQ 574

Query: 1029 AEVLLLQQRVAALAEEKSRAQEKVTE-------------------KEVVKLQNDPQLEAE 1069
             E+ + +     LA    RA+ KV                     KE V L N  ++E +
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLAN--RIEQQ 632

Query: 1070 YQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATERE 1129
            YQ +      +  +  K      +L +++ R+      A    ++K +L  E     ++ 
Sbjct: 633  YQNVLT-LWHESHINMKSVVSWHYLINEIDRIR-----ASNVASIKTMLPGEH----QQV 682

Query: 1130 VSDLTRQYEDEAAKARASQ----REKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAE 1185
            +S+L  ++ED    ++ SQ     + T+L +++        K   QE ++   R +   E
Sbjct: 683  LSNLQSRFEDFLEDSQESQVFSGSDITQLEKEV-----NVCKQYYQELLKSAEREEQ--E 735

Query: 1186 SEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEME 1245
              V NL +  V   R        LR    E   +R+    +E  ++ + V +     +++
Sbjct: 736  ESVYNLYISEVRNIR--------LRLENCEDRLIRQIRTPLERDDLHESVFRITEQEKLK 787

Query: 1246 KELQRLREEIVDKTRLIER------CDLEIYQLKKEIQALKDTKPQVQTK-----EVVQE 1294
            KEL+RL++++   T   E           +  L+ E+  +     QV +      + ++ 
Sbjct: 788  KELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKT 847

Query: 1295 ILQFQEDPQTKEEVASL-RAKLSEEQKKQVDLE------------RERASQEEQIARK-E 1340
            +    ++ Q  E +  L   KL EE+    D              R    ++ Q+    E
Sbjct: 848  VNLVLKNTQAAEALVKLYETKLCEEEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALE 907

Query: 1341 EELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELE 1400
            +EL + K   +  E+ +  +E  L           D    + D+L   + R Q    +++
Sbjct: 908  DELQKAK--AISDEMFKTYKERDL---------DFDWHKEKADQL---VERWQNVHVQID 953

Query: 1401 RQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQ----- 1455
             +L +LE   ++ +        L   +  +E  + + +E      K +  Q  QQ     
Sbjct: 954  NRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLATQLNQQKMLVS 1013

Query: 1456 ---AREHALLRLQLEEEQHRRQLLEGELETL--RRKLAALEKAEVKEK-------VVLSE 1503
                ++  +   Q   EQ+   + + EL+T+  R  + + +K+ VK +       +++ E
Sbjct: 1014 EIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQE 1073

Query: 1504 SVQVEKGDT------EQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKE 1557
             + +    T       Q I+    SL+     ++ L+ E      +  EL+   S  SK 
Sbjct: 1074 FMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKT 1133

Query: 1558 LDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLER 1617
            L    E+  K    +Q +  E    + E    A +T  L      D  T+ +     LE+
Sbjct: 1134 LKD-AEKAGKPPFSKQKISSEEISTKKEQLSEALQTIQLFLAKHGDKMTDEERN--ELEK 1190

Query: 1618 ELDDLKRLSKDKDLEIDELQKRLGSVAVKREQR-ENHLRRSIV-VIHPDTGRELSPEEAH 1675
            +   +K L +  +L   E  K+L       + + E  L + I   I   TG  LS  +A 
Sbjct: 1191 Q---VKTLQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAV 1247

Query: 1676 RAGLIDWNMFVKL 1688
              GLID++  ++L
Sbjct: 1248 LRGLIDYDTGIRL 1260



 Score = 52.4 bits (124), Expect = 4e-06
 Identities = 138/713 (19%), Positives = 281/713 (39%), Gaps = 129/713 (18%)

Query: 608  QEKVDVANRLEKSLQQSWELLATHENHLNQDDTVP------ESSRVLDSKGQELAAMACE 661
            +E VD+ANR+E+  Q    L   HE+H+N    V       E  R+  S    +  M   
Sbjct: 620  KEAVDLANRIEQQYQNV--LTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTM--- 674

Query: 662  LQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQE----AEVHKLGQRFNNLRQQ 717
                  L GE +Q L       S L SRF++   D +  +    +++ +L +  N  +Q 
Sbjct: 675  ------LPGEHQQVL-------SNLQSRFEDFLEDSQESQVFSGSDITQLEKEVNVCKQY 721

Query: 718  VERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYE---------PQETDSLSQMETKLK 768
             +   +S +  +     ++     V    + + + E         P E D L +   ++ 
Sbjct: 722  YQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQIRTPLERDDLHESVFRIT 781

Query: 769  NQKNLLDEIASREQEVQKICANSQQY-QQAVKDYELEAEK------LRSLLDLENGRSSH 821
             Q+ L  E+   + ++  I    +++  QA     +   +      L+++  + +  S++
Sbjct: 782  EQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSVPTLRSELNVVLQNMNQVYSMSSTY 841

Query: 822  VSK--------------RARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLL 867
            + K               A ++   TK+ EEEA +A K             N+E  ++ L
Sbjct: 842  IDKLKTVNLVLKNTQAAEALVKLYETKLCEEEAVIADK------------NNIENLISTL 889

Query: 868  RQ-QPEVE-------VTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEE 919
            +Q + EV+          + LQ+ +  S  +E +K  KE D + +  ++  +++    + 
Sbjct: 890  KQWRSEVDEKRQVFHALEDELQKAKAIS--DEMFKTYKERDLDFDWHKEKADQLVERWQN 947

Query: 920  IWTLRNQGPQESVVRKEVLKKVPDPV--LEESFQQLQRTLAEEQHKNQLLQEELEALQLQ 977
            +    +   ++     + LK   D    L++  QQ++ T  + Q +NQ   E  + L  Q
Sbjct: 948  VHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQ-ENQ--PENSKTLATQ 1004

Query: 978  LRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQR 1037
            L           Q+ +V E   IE  +++ DE  +  E+  A       ++ E+  +  R
Sbjct: 1005 LNQ---------QKMLVSE---IEMKQSKMDECQKYAEQYSAT-----VKDYELQTMTYR 1047

Query: 1038 VAALAEEKSRAQEKVTEKEV-VKLQNDPQLEAEYQQL-----QEDHQRQDQLREKQEEEL 1091
                +++KS  + +  +    + +Q    L   Y  L     Q      D L+  +EEE 
Sbjct: 1048 AMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEK 1107

Query: 1092 SFLQDKLKRLEKERAMAEGKITVKEVLK---------VEKDAATEREVSDLTRQYEDEAA 1142
            S  ++K + +EK + + +    + + LK           K   +  E+S    Q  +   
Sbjct: 1108 SLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167

Query: 1143 KA---------RASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRL 1193
                       + +  E+ EL +++  L +E+  ++  E ++++       + +V   +L
Sbjct: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTL-QESYNLLFSESLKQLQESQTSGDVKVEE-KL 1225

Query: 1194 ELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEK 1246
            + V      +   E L  +Q+ L  L      + + E T+ +I     PE+ K
Sbjct: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLE-TQLMISGLISPELRK 1277


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score =  249 bits (637), Expect = 1e-65
 Identities = 388/1948 (19%), Positives = 768/1948 (39%), Gaps = 309/1948 (15%)

Query: 27   LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86
            L ++  ++Q  A   E+ +   +  +Q+D A L+ G+  +     +  + + E L+  L+
Sbjct: 429  LLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQ 488

Query: 87   ADAAIAKHMKHPQGDMIAEDIRQLKERV-------TNLRGK-----------------HK 122
             D  I +   + Q + +A  + +L++ +       TNL  K                 H 
Sbjct: 489  VDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHL 548

Query: 123  QIYRLAVKEVDPQVNW----------------------------AALVEEKLDKLNNQSF 154
            +   L         +W                             + VEE   KL    +
Sbjct: 549  KAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEW 608

Query: 155  GTDLPLVDHQVEEHNIFHNEVKAIGPHLAK----DGDKEQN---------SELRAKYQKL 201
            G DLP V+ Q+E     H  V+ +G  + +    +G   QN          +L  +Y KL
Sbjct: 609  GNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKL 668

Query: 202  LAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINR 261
               S  R +HL SL  ++ R T EL WL+++ +  + YDWSD N +  S +R Y + +  
Sbjct: 669  KETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNI-SAKRNYFSELTM 727

Query: 262  NLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMED 321
             LE K++    L    + L    HP + ++EA+  AV +  +    L +C E H+K    
Sbjct: 728  ELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTA 787

Query: 322  YHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRY-QIELLLRELDDQEKVLDKYEDVVQG 380
            Y QF  D ++ +  LR +   + +KY  D      ++E LL++  D+++ L + +  V  
Sbjct: 788  YFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVAS 847

Query: 381  LQKRGQQVVPLKYRRETPL--KPIPVEALCDFEGEQGLISRGYSYTLQKNNGES-WELMD 437
            L  R + +V LK R    +    I V+A+CD+   +  I +     L+ N+  + W+++ 
Sbjct: 848  LVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVIS 907

Query: 438  SAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSV----RQKAAGSKRTLQQRY----- 488
              GN+ + P+VCF+IPP + +A+ +A  +   Y+ V     Q    +K  +   Y     
Sbjct: 908  PTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDL 967

Query: 489  --------EVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQ 540
                    E L++  PG+   +         D +    D    ++   LR   E      
Sbjct: 968  DLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKA 1027

Query: 541  DSAERAKDLKN--------------ITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLL 586
                  K ++N              + N  LR+E  + R     ++   +          
Sbjct: 1028 RFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDN 1087

Query: 587  RTRVEDTNRKYEHLLQL------------------------------LDLAQEKVD---- 612
              R+ +     E L QL                              L+L  EK+D    
Sbjct: 1088 ALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYG 1147

Query: 613  ----VANRLE------KSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACEL 662
                  N+L+      +S+Q +  L+  +E  L+Q++ V      L++    L     ++
Sbjct: 1148 LSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDV 1207

Query: 663  QAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRA 722
            + + S+   +++ +  AK  +  ++    E   DLER + +  +L +R++ +  Q+E R 
Sbjct: 1208 KDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQ 1267

Query: 723  QSLQSAKAAYEHFHRGHDHVLQFLVSIPSYE----PQETDSLSQMETKLKNQKNLLDEIA 778
              L+S +     +   H  +++++    + +    P + +    +  +L  Q  L  EI 
Sbjct: 1268 SELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIE 1327

Query: 779  SREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEE 838
              + ++ +    SQQY   VKDYEL+    ++ ++    +     KR R+ S +  + +E
Sbjct: 1328 RNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVE---SQQKSPGKRRRMLSSSDAITQE 1384

Query: 839  EAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKE 898
               L  ++T +  +  Q ++ +  AL   R + E +V  E  Q        E   K+++ 
Sbjct: 1385 FMDLRTRYTALVTLTTQHVKYISDALR--RLEEEEKVVEEEKQ--------EHVEKVKEL 1434

Query: 899  LDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLA 958
            L   +   R  + +  S++ +  T   +   E  V  E L    + V  E+ +  Q  LA
Sbjct: 1435 LGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQV-SEAIKTSQIFLA 1493

Query: 959  EEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELE 1018
            +  HK  L ++E + +  QL AL +   D                   A+++ QL+ +L 
Sbjct: 1494 KHGHK--LSEKEKKQISEQLNALNKAYHDLCD--------------GSANQLQQLQSQLA 1537

Query: 1019 ALRRQKGAREAEVLLLQQ--RVAALAEEKSRA----QEKVTEKEVVKLQNDPQLEAEYQQ 1072
                QK  ++ +    QQ   + +   +  RA    Q + T++++  LQ +   +++ + 
Sbjct: 1538 HQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKN---QSDLKD 1594

Query: 1073 LQEDHQ-RQDQLREKQEEELSFLQDKLKRLEKER--AMAEGKITVKEVLKV--EKDAATE 1127
            LQ+D Q R        ++   F+++   +L      A+ E     KE  +   E+    +
Sbjct: 1595 LQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQ 1654

Query: 1128 REVSD-LTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAES 1186
            +E+ + +T   + E  K++A+ +E  E  +KI AL +      V     +++   P  E 
Sbjct: 1655 KELEEAVTSALQQETEKSKAA-KELAENKKKIDALLDWVTS--VGSSGGQLLTNLPGMEQ 1711

Query: 1187 -EVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQV-----------EVKEVTKE 1234
               A+L    ++    Y G  +       + E ++ R  ++           +  +   +
Sbjct: 1712 LSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLD 1771

Query: 1235 VIKYKTDPEMEKELQRLREEIVDK-TRLIERCDLEIYQ-------LKKEIQALKDTKPQV 1286
               +   PE ++ LQ+   E+ ++ +  + + + E+ Q       L+K +Q  K+ +  +
Sbjct: 1772 QHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWL 1831

Query: 1287 QTKE-VVQEILQFQEDPQTKEEVASLRAKLSEE------QKKQVDLERERASQEEQIARK 1339
            +  E  ++ + +    P+T   +   +   SE+        + V +  ++    E   ++
Sbjct: 1832 ERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKE 1891

Query: 1340 EEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTEL 1399
             +E S +   V  +     E    L ++ +     +++ L Q  + +     LQ      
Sbjct: 1892 GKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQAC 1951

Query: 1400 ERQL----------------EELERERQARRE-AEREV-----QRLQQRLAALEQEEAEA 1437
            E  +                E+L   +Q + E AE +V     Q++ + +  +E E A  
Sbjct: 1952 EANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPD 2011

Query: 1438 REKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEK-AEVK 1496
               V  T   +L      +   A     L++   + Q ++  LE+L + +  +E+  E K
Sbjct: 2012 HRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGK 2071

Query: 1497 EKVVLSESVQVEKGDT----EQEIQRLKSSLE--------------------------EE 1526
            +   LS  V  E   T    +Q+I R KSSLE                          E 
Sbjct: 2072 QVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEV 2131

Query: 1527 SRSKRELDVEVSRLEARLSEL----EFHNSKSSKELDFLREENHKL-------------- 1568
            S+   +L ++    E+ L +L    E     S K   F+  ++  L              
Sbjct: 2132 SQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFF 2191

Query: 1569 -QLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSK 1627
             Q++  NL++E +  Q  ++       +L +   A     H  R+ +L ++  +L++  K
Sbjct: 2192 QQIQELNLEMEDQ--QENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVK 2249

Query: 1628 DKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPD----TGRELSPEEAHRAGLI-DW 1682
            +++ +    Q++L          +  L+ +   I P     + +EL  +  H   L+ DW
Sbjct: 2250 EREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDW 2309

Query: 1683 NMFVKLRSQECDWEEISVKGPNGESSVI 1710
                   S+    EEI+ KG + E+ ++
Sbjct: 2310 ------ASKGTLVEEINCKGTSLENLIM 2331



 Score = 90.1 bits (222), Expect = 2e-17
 Identities = 312/1621 (19%), Positives = 619/1621 (38%), Gaps = 293/1621 (18%)

Query: 324  QFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDK-YEDVVQGLQ 382
            Q  E +K +Q  L K    L++K               +++ +Q   L+K Y D+  G  
Sbjct: 1480 QVSEAIKTSQIFLAKHGHKLSEKEK-------------KQISEQLNALNKAYHDLCDGSA 1526

Query: 383  KRGQQVVPLKYRRETPLKPIP---------VEALCDFEGE--------QGLISRGYSYTL 425
             + QQ+   +   +T  K +          +E LC + G+        QG  ++     L
Sbjct: 1527 NQLQQLQS-QLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSAL 1585

Query: 426  QKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYR---SVRQKAAGSKR 482
            QKN  +  +L D   N+    A  F     D E     +      R   ++R+K   +K 
Sbjct: 1586 QKNQSDLKDLQDDIQNR----ATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAK- 1640

Query: 483  TLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDS 542
               ++YE L+ E      +L                   E+A+T  L+   E+ +A ++ 
Sbjct: 1641 ---EQYEALQEETRVAQKEL-------------------EEAVTSALQQETEKSKAAKEL 1678

Query: 543  AERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG----SGTTPLLRTRVEDTNRKYE 598
            AE  K +  + + +       T   + G   +  LPG    SG +  L     DT   Y 
Sbjct: 1679 AENKKKIDALLDWV-------TSVGSSGGQLLTNLPGMEQLSGAS--LEKGALDTTDGYM 1729

Query: 599  HLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHL------------NQDDTVPESSR 646
             + Q    A EK+D    + K+  Q  ELL+  +N +            +  +  PE  +
Sbjct: 1730 GVNQ----APEKLDKQCEMMKARHQ--ELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQ 1783

Query: 647  VLDSKGQEL--------AAMACELQAQKSLLGEVEQNLQAAKQCSSTL------------ 686
            +L  K  EL        A    EL+  ++L  E+++ LQ  K+  S L            
Sbjct: 1784 MLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHK 1843

Query: 687  ASRFQEHCPDLERQEAEV------HKLGQRF------------NNLRQQVERRA------ 722
                 E  P L +++         HK   RF            N+ ++  E         
Sbjct: 1844 GGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVK 1903

Query: 723  QSLQSAKAAYEHFH----RGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLL-DEI 777
              L+ A   Y   H    R   H+   L     ++       + M+    N + LL D +
Sbjct: 1904 DKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTV 1963

Query: 778  ASREQEVQKICANSQQYQQAVKDYELEAEKL----RSLLDLENGRS-SHVSKRARLQSPA 832
            AS    +Q+  A ++Q Q+ + ++++  EKL    R ++++E   +  H   +    S  
Sbjct: 1964 ASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSIL 2023

Query: 833  TKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGV-EE 891
            +  +    +LA + + +     Q     E   +LL+   EVE   E  Q +   SGV +E
Sbjct: 2024 SHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQE 2083

Query: 892  AWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQ 951
            A     +L ++  R++   + +++T+E +          +         V    L E  Q
Sbjct: 2084 ALATNMKLKQDIARQK---SSLEATREMVTRFMETADSTTAA-------VLQGKLAEVSQ 2133

Query: 952  QLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRI-----EPDRAQ 1006
            + ++   ++Q K   L++ L   ++       E   G  +  ++   R+     +PD+  
Sbjct: 2134 RFEQLCLQQQEKESSLKKLLPQAEM------FEHLSGKLQQFMENKSRMLASGNQPDQDI 2187

Query: 1007 ADEVLQLRE-ELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQ 1065
                 Q++E  LE   +Q+     E L+ +      A +  + Q++V        QN   
Sbjct: 2188 THFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRV--------QN--- 2236

Query: 1066 LEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAA 1125
            L  ++ +LQ+  + +++     +E+L   +  ++  +K     EG I   E     K+  
Sbjct: 2237 LRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKE-- 2294

Query: 1126 TEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAK-VVVQEKVREIVRPDPKA 1184
             E+++  L    +D A+K                 +EE N K   ++  + EI  PD + 
Sbjct: 2295 LEKQIEHLKSLLDDWASKGT--------------LVEEINCKGTSLENLIMEITAPDSQG 2340

Query: 1185 ES---------------------EVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRG 1223
            ++                     ++  ++ ++ +   KY      L   Q  L+A+  R 
Sbjct: 2341 KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRM 2400

Query: 1224 PQV-----------EVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQL 1272
             +V           E KE   + +   + P   + ++   E        +E+   +I ++
Sbjct: 2401 EEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKV 2460

Query: 1273 KKEIQALKDTKPQVQTKE---VVQEILQFQEDPQTKEEVASLRA-----------KLSEE 1318
            K+ +  L  T P  Q  E    +QE L  + +  T+  VA  R            + +E 
Sbjct: 2461 KEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAES 2520

Query: 1319 QKKQVDLERE-----------------RASQEEQIARKEEELSRVKERVVQQEVVRYEEE 1361
            Q +   +E+E                    Q+ Q   KE E  R +   + +        
Sbjct: 2521 QLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTG 2580

Query: 1362 PGLRAEASAFAESIDVELRQIDKLRAELR-RLQRRRTELERQLEELERERQARREAEREV 1420
            PG   + S     +  EL+ I++   EL  +L  R +++++ + +  + ++  ++   +V
Sbjct: 2581 PG---DVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKV 2637

Query: 1421 QRLQQRL---AALEQEEAEAREKVTHTQKV--VLQQDPQQAREHALLRLQLE---EEQHR 1472
            + + QRL   +A+  +    ++++  T ++   L+Q   + +E   L  +L     EQ+ 
Sbjct: 2638 RAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGEQYL 2697

Query: 1473 RQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRE 1532
            +  L+  LET+   L  LE     +++   ++        +Q    L++ L+++   + +
Sbjct: 2698 KDELKKRLETVALPLQGLEDL-AADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAK 2756

Query: 1533 ---LDVEVSRLEARLSE-LEFHNS--KSSKELDFLREENHKLQL------ERQNLQLETR 1580
               +  ++ RL+++L E  EF  S  + S   + +  E   L L      E++ LQ +  
Sbjct: 2757 NCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLV 2816

Query: 1581 RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLE---RELDDLKRLSKDKDLEIDELQ 1637
             L++     + +T D R   + D         W +E     ++D K    +  + +D +Q
Sbjct: 2817 ELKNHWEELSKKTAD-RQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQ 2875

Query: 1638 KRLGSVAVKREQRENHLRRSIV-VIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWE 1696
                 +  K    E   RRS++ +++      ++  EA   G+ D    +  ++ +   E
Sbjct: 2876 LESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGIN-QNMDAVTE 2934

Query: 1697 EISVKGPNGESSVIHDRKSGKKF-SIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQ 1755
            E+  K  + E      R+  + F +IE+ ++  +     +D   ++  S + L  L + Q
Sbjct: 2935 ELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLEKLRAQQ 2994

Query: 1756 K 1756
            +
Sbjct: 2995 E 2995



 Score = 75.1 bits (183), Expect = 6e-13
 Identities = 269/1445 (18%), Positives = 570/1445 (39%), Gaps = 199/1445 (13%)

Query: 257  NFINRNLEAKEERINKLHSEG-------DQLLAAEHPGRNS---IEAHMEAVHADWKEYL 306
            N +   L+   ER   LHS+        + LL   H  +NS   ++A M+A  A+ ++ L
Sbjct: 1900 NLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLL 1959

Query: 307  NLLICEESHL--KYMEDYHQFHEDVKDAQ---ELLRKVDSDLNQKYGPDFKDRYQIELLL 361
            +  +  +  +  + +    Q  E++ + Q   E L+KV  D+ +  G    D   ++   
Sbjct: 1960 SDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQ--- 2016

Query: 362  RELDDQEKVLDKYEDVVQGLQKRGQ-------QVVPLKYRRETPLKPIPVEALCDFEGEQ 414
               +  + +L  ++ +   L +R         Q   ++   E+ L+ I  E   + EG+Q
Sbjct: 2017 ---ETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIG-EVEQNLEGKQ 2072

Query: 415  GLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVR 474
              +S   S  +Q+    + +L      +  +      +  T        ++  S   +V 
Sbjct: 2073 --VSSLSSGVIQEALATNMKLKQDIARQKSS------LEATREMVTRFMETADSTTAAVL 2124

Query: 475  QKAAGSKRTLQQRYEVLKTENPGDASDLQG---------------RQLLAGLDKVASDLD 519
            Q   G    + QR+E L  +     S L+                +Q +    ++ +  +
Sbjct: 2125 Q---GKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181

Query: 520  RQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579
            + ++ IT   +   E    ++D  E    L+++  EL            + +  +Q L  
Sbjct: 2182 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCG--FALDLCQHQDRVQNLRK 2239

Query: 580  SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDD 639
              T   L+  V++  +      + LD  ++ V    +  K  + S     T  +    + 
Sbjct: 2240 DFTE--LQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEK 2297

Query: 640  TVPESSRVLD---SKGQELAAMACELQAQKSLLGEVEQNLQAAKQCS------STLASRF 690
             +     +LD   SKG  +  + C+  + ++L+ E+       K  S      S++ S  
Sbjct: 2298 QIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVN 2357

Query: 691  QEH-CPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVS- 748
              H C DL   + ++  +  ++  L   +  R +SLQ+     E  H+  + VLQ+L S 
Sbjct: 2358 GYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESK 2417

Query: 749  ---IPSYEPQETDSLSQ-METKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDY--E 802
               + S +   + + ++ ++ + ++ K  L E+     ++QK+    +     +  Y   
Sbjct: 2418 EEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKV---KEALAGLLVTYPNS 2474

Query: 803  LEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEF 862
             EAE  + + +  N R    ++   +     +  EE A+  A F    +  R  L   E 
Sbjct: 2475 QEAENWKKIQEELNSRWERATE---VTVARQRQLEESASHLACFQAAESQLRPWLMEKEL 2531

Query: 863  ALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWT 922
             + +L           ++  N  ++  ++   + KE     E RRQ   ++    + I T
Sbjct: 2532 MMGVLGPL--------SIDPNMLNAQKQQVQFMLKEF----EARRQQHEQLNEAAQGILT 2579

Query: 923  LRNQGPQE-SVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQ--LR 979
                GP + S+   +V K++    + + + +L   L      +Q+ Q  +++ Q Q  L+
Sbjct: 2580 ----GPGDVSLSTSQVQKELQS--INQKWVELTDKL--NSRSSQIDQAIVKSTQYQELLQ 2631

Query: 980  ALEQETRDGGQEYVVKEVLRIEPD--RAQADEVLQLREELEALRRQKGAREAEVLLLQQR 1037
             L ++ R  GQ   V+  +  +P+  + Q +E  ++R +LE L  +   +EA+ L     
Sbjct: 2632 DLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHE--VKEAQTLC--DE 2687

Query: 1038 VAALAEEKSRAQEKVTEKEVVKL----------QNDPQLEAEYQQLQEDHQRQDQLR--- 1084
            ++ L  E+    E     E V L              +L+A     Q+  Q  D+LR   
Sbjct: 2688 LSVLIGEQYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWL 2747

Query: 1085 -EKQEEE---------LSFLQDKLKRLEK------------ERAMAEGKITVKEVLKVEK 1122
             +KQ ++         L  LQ +L+  E+            E  +AEG+  +  V   E+
Sbjct: 2748 DDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEE 2807

Query: 1123 DAATEREVSDLTRQYEDEAAKARASQREKTELLRKI----WALEE-----ENAKVVVQEK 1173
                + ++ +L   +E+ + K    Q    + ++K     W +E+     E+ K  + E 
Sbjct: 2808 KRTLQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSE- 2866

Query: 1174 VREIVRPDPKAESEVANLRLELVEQERK-------YRGAEEQLRSYQSELEALR--RRGP 1224
            +R  + P  + ES +   +  L E E++          A+  + S +++ + +R  + G 
Sbjct: 2867 LRVTLDP-VQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGI 2925

Query: 1225 QVEVKEVTKEV-IKYKTDPEMEKELQRLREEIVDKTRLIE--RCDLEIYQL-------KK 1274
               +  VT+E+  K  +  EM + L+  +E   +  + +E  +  LEI+          K
Sbjct: 2926 NQNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEGAKHQLEIFDALGSQACSNK 2985

Query: 1275 EIQALKDTKPQVQTKEVVQEILQ-----FQEDPQTKEEVASLRAKLSEEQKKQVDLERER 1329
             ++ L+  +  +Q  E   + L+       ED     + + L  +    Q++ +++++  
Sbjct: 2986 NLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRV 3045

Query: 1330 ASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAEL 1389
             S    +  K E + +   RV +      + +  L     A     D    QI+ +R  L
Sbjct: 3046 NSGCVMMENKLEGIGQFHCRVREMFSQLADLDDELDG-MGAIGRDTDSLQSQIEDVRLFL 3104

Query: 1390 RRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQ------EEAEAREKVTH 1443
             ++   + ++E    E E       E   ++  L++ L AL +      E  +AR++   
Sbjct: 3105 NKIHVLKLDIE--ASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQLE 3162

Query: 1444 TQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSE 1503
                 ++   ++ +         EE +  + ++  E+E + ++LA  +  + ++   L  
Sbjct: 3163 LTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPLQM 3222

Query: 1504 SVQ---------VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKS 1554
             +Q         ++    + ++Q L+  +EE +     L+ +V++  A+L E   H  K 
Sbjct: 3223 KLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKF 3282

Query: 1555 SKELD 1559
               L+
Sbjct: 3283 QDALE 3287



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 343/1807 (18%), Positives = 713/1807 (39%), Gaps = 257/1807 (14%)

Query: 8    RNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEH 67
            +N    +  +Q ++ S +E+++ + + Q++   +EK +    AK Q ++      +   +
Sbjct: 2927 QNMDAVTEELQAKTGSLEEMTQRLREFQESFKNIEKKVEG--AKHQLEIFDALGSQACSN 2984

Query: 68   RDVTLQKVLDSEKLLYVLEA-----------------DAAIAKHMKHPQGDMIAEDIRQL 110
            ++  L+K+   +++L  LE                  D + A  + H Q ++  ++  ++
Sbjct: 2985 KN--LEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLH-QAEVAQQEFLEV 3041

Query: 111  KERVTN----LRGKHKQI--YRLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQ 164
            K+RV +    +  K + I  +   V+E+  Q+   A ++++LD +   + G D   +  Q
Sbjct: 3042 KQRVNSGCVMMENKLEGIGQFHCRVREMFSQL---ADLDDELDGMG--AIGRDTDSLQSQ 3096

Query: 165  VEEHNIFHNEVKAIG----------PHLAKD-------GDKEQNSELRAKYQKLLAASQA 207
            +E+  +F N++  +            H+ ++       G K +   L  +  KL    +A
Sbjct: 3097 IEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKA 3156

Query: 208  RQQHLS----SLQDYMQRCT--NELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINR 261
            RQ+ L      ++D+ ++    N+     ++A+  +Q+           +   ++ F   
Sbjct: 3157 RQEQLELTLGRVEDFYRKLKGLNDATTAAEEAEA-LQWVVGTEVEIINQQLADFKMFQKE 3215

Query: 262  NLEAKEERINKLHSEGDQLL--AAEHPGRNSIEAHMEAVHADW-----KEYLNLLICEES 314
             ++  + ++ +++  G  L+  A +      +E  ME ++A W     K    +   +E+
Sbjct: 3216 QVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEA 3275

Query: 315  HL---KYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVL 371
             L   K+ +        + D +EL+       NQK  P   +   ++  ++E    +++L
Sbjct: 3276 LLHCGKFQDALEPLLSWLADTEELIA------NQK--PPSAEYKVVKAQIQEQKLLQRLL 3327

Query: 372  DKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGE 431
            D  +  V  LQ  G ++       +       +E+L     E  L+S+  +   Q    E
Sbjct: 3328 DDRKATVDMLQAEGGRIAQSAELADREKITGQLESLESRWTE--LLSKAAARQKQL---E 3382

Query: 432  SWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVL 491
               ++    ++   P   F+      + LA ++ +G+Q   ++Q+          R++ L
Sbjct: 3383 DILVLAKQFHETAEPISDFL--SVTEKKLANSEPVGTQTAKIQQQII--------RHKAL 3432

Query: 492  KTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKN 551
            + +    A+D+          K+   L          L  P EQG      +E+   L+ 
Sbjct: 3433 EEDIENHATDVHQAV------KIGQSLSS--------LTSPAEQGVL----SEKIDSLQA 3474

Query: 552  ITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKV 611
              +E+      + R   +     QAL  +         V +   + E  L  + +   K 
Sbjct: 3475 RYSEI------QDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQ 3528

Query: 612  DVANRLEKSLQQSWELLATHENHLNQDDTVPESSR-----VLDSKGQELAAMACELQAQK 666
            DV +R      Q  + LA +E  +N+   V ++ +     +  + G+E+  +  +L   K
Sbjct: 3529 DVLHR------QHADHLALNEEIVNRKKNVDQAIKNGQALLKQTTGEEVLLIQEKLDGIK 3582

Query: 667  SLLGEVE-------QNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQ--Q 717
            +   ++        + L+ A+Q ++   S ++E    L   E E+   G +     Q  Q
Sbjct: 3583 TRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQSPTGEQIPQ 3642

Query: 718  VERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLL-DE 776
             ++R + L+     +       + V + L+ +  +  +E   L ++ +    Q  L+ D 
Sbjct: 3643 FQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRARE--GLDKLVSDANEQYKLVSDT 3700

Query: 777  IASREQEVQKICANSQQYQQAVKDYELE--AEKLRSLLDLENGRSSHVSKRARLQSPAT- 833
            I  R  E+      SQQY+QA  D EL   AE  R L+ L   R       A+LQ     
Sbjct: 3701 IGQRVDEIDAAIQRSQQYEQAA-DAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAF 3759

Query: 834  -----KVKEEEAALAAKFTEVYAI--NRQRLQNLEFALNLLRQQPEVEV--THETLQRNR 884
                 + K+    L +  +E++      Q+    E   +L++Q   + +  +    +  R
Sbjct: 3760 SIDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLER 3819

Query: 885  PDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVP-- 942
                V + W+  +EL    E  R L  ++ S   +   LR Q  +   +R+ + +  P  
Sbjct: 3820 AQVLVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHI 3879

Query: 943  DPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG--GQEYVVKEVLRI 1000
            D +L+    QL+    EE    ++++E+ +  +     +++E R      +  V +  +I
Sbjct: 3880 DKLLKIG-PQLKELNPEE---GEMVEEKYQKAENMYAQIKEEVRQRALALDEAVSQSTQI 3935

Query: 1001 EPDRAQADEVLQLREELEALRRQKGAREAEV-----LLLQQRVAALAEEKSRAQEKVTEK 1055
                 + + +L+  E L +  R      AEV      +   + A +  EK +   +  ++
Sbjct: 3936 TEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKR 3995

Query: 1056 EVVKLQNDPQLEAEYQQLQEDHQRQDQL--------REKQEEELSFLQDKLKRLEK-ERA 1106
               +L    Q   +    +E   + DQ+           +E E+ FL D L+  EK    
Sbjct: 3996 RGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFL-DVLELAEKFWYD 4054

Query: 1107 MAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENA 1166
            MA    T+K+   +  D  +      + +Q  + A   +       E L  I  L  +  
Sbjct: 4055 MAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEFIRILGADLI 4114

Query: 1167 KVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQV 1226
                + +  E+ +   +  +   NL     E+  K   A +    YQ  L+A+       
Sbjct: 4115 FACGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAM------- 4167

Query: 1227 EVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQV 1286
                +   VIK  T P +  +L  +++++ +    ++   +E+YQ + E++ L       
Sbjct: 4168 -FDWLDNTVIKLCTMPPVGTDLNTVKDQLNE----MKEFKVEVYQQQIEMEKLNHQ---- 4218

Query: 1287 QTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRV 1346
                   E++  +   +T  ++  +R  L+E +    +L  + A ++ ++      L + 
Sbjct: 4219 ------GELMLKKATDETDRDI--IREPLTELKHLWENLGEKIAHRQHKLEGALLALGQF 4270

Query: 1347 KERV--VQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
            +  +  +   +   EE    +   S   + I+VEL +   L+ ++   Q     + +   
Sbjct: 4271 QHALEELMSWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN 4330

Query: 1405 ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAR------E 1458
            EL         A  +   L+ RL A+ Q      +K T  ++  LQ   QQA+      E
Sbjct: 4331 EL-----LESSAGDDASSLRSRLEAMNQCWESVLQK-TEEREQQLQSTLQQAQGFHSEIE 4384

Query: 1459 HALLRLQLEEEQHRRQLLEGEL-ETLRRKL----AALEKAEVKEK-----------VVLS 1502
              LL L   E Q       G L ET R +L        + + KE+           ++LS
Sbjct: 4385 DFLLELTRMESQLSASKPTGGLPETAREQLDTHMELYSQLKAKEETYNQLLDKGRLMLLS 4444

Query: 1503 ESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLR 1562
                     TEQ +  L          +++  V  S++E R S+LE   + +++  + L+
Sbjct: 4445 RDDSGSGSKTEQSVALL----------EQKWHVVSSKMEERKSKLEEALNLATEFQNSLQ 4494

Query: 1563 EENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDL 1622
            E  + L L  Q+L + +      + +    ++   +   A+    H  ++  L++  + L
Sbjct: 4495 EFINWLTLAEQSLNIAS---PPSLILNTVLSQIEEHKVFANEVNAHRDQIIELDQTGNQL 4551

Query: 1623 KRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELS-----PEEAHRA 1677
            K LS+ +D+ +  ++  L SV   + + E  ++RSI     + GR L       ++ H A
Sbjct: 4552 KFLSQKQDVVL--IKNLLVSV---QSRWEKVVQRSI-----ERGRSLDDARKRAKQFHEA 4601

Query: 1678 --GLIDW 1682
               LIDW
Sbjct: 4602 WKKLIDW 4608



 Score = 67.8 bits (164), Expect = 9e-11
 Identities = 326/1715 (19%), Positives = 645/1715 (37%), Gaps = 316/1715 (18%)

Query: 25   KELSELIEQLQKNADQVEKNIVD-TEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLY 83
            +EL+  +E  Q+N D +E  + + +      DL + Q+  Q   +D T     + +K + 
Sbjct: 2195 QELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFT-----ELQKTVK 2249

Query: 84   VLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQV------- 136
              E DA+  +        ++    + LKE   ++         ++ KE++ Q+       
Sbjct: 2250 EREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETS---MSAKELEKQIEHLKSLL 2306

Query: 137  -NWAA---LVEE---KLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGP----HLAKD 185
             +WA+   LVEE   K   L N       P  D Q +  +I  +   ++G     H  KD
Sbjct: 2307 DDWASKGTLVEEINCKGTSLENLIMEITAP--DSQGKTGSILPSVGSSVGSVNGYHTCKD 2364

Query: 186  GDKEQ--NSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNE----LYWLDQQAKGRMQY 239
              + Q   S++  KY+KL      RQ+ L ++ + M+    E    L WL+ + +     
Sbjct: 2365 LTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSM 2424

Query: 240  DWSDRNLDYPSRRRQYEN--FINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAH--- 294
            D         + + Q E+       LE    +I K+  E    L   +P  NS EA    
Sbjct: 2425 DAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKV-KEALAGLLVTYP--NSQEAENWK 2481

Query: 295  --MEAVHADWKEYLNLLICEE-------SHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQ 345
               E +++ W+    + +  +       SHL   +            +EL+  V   L+ 
Sbjct: 2482 KIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI 2541

Query: 346  KYGPDFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVE 405
                    + Q++ +L+E + + +  ++  +  QG                         
Sbjct: 2542 DPNMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQG------------------------- 2576

Query: 406  ALCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADS 465
             +    G+  L +      LQ  N +  EL D   ++                 +  A  
Sbjct: 2577 -ILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSR--------------SSQIDQAIV 2621

Query: 466  LGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAI 525
              +QY+ + Q  +   R + QR   L  ++         +Q L    ++ SDL++ +  +
Sbjct: 2622 KSTQYQELLQDLSEKVRAVGQR---LSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEV 2678

Query: 526  TGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPL 585
                       +  Q   +    L  I  + L+ E +K   T        ALP  G   L
Sbjct: 2679 -----------KEAQTLCDELSVL--IGEQYLKDELKKRLETV-------ALPLQGLEDL 2718

Query: 586  LRTRV----------EDTNRKYEHLLQLLDLAQEK-------VDVANRLEKSLQQSWELL 628
               R+          +   + ++ L   LD  Q +            RL+  LQ++ E  
Sbjct: 2719 AADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQ 2778

Query: 629  ATHENHLNQDDTV---PESSRVLDSKGQELAAMACELQAQKSLLGEVEQNL----QAAKQ 681
             +   H    + +    ES  +    G+E   +  +L   K+   E+ +         K 
Sbjct: 2779 KSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADRQSRLKD 2838

Query: 682  CSSTLASRFQEHCPDL----ERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHR 737
            C    A ++Q H  DL    E  +A++ +L    + ++ +      SL  +KA      +
Sbjct: 2839 CMQK-AQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLE-----SSLLRSKAMLNEVEK 2892

Query: 738  GHDHVLQFL-----VSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQ 792
                +L+ L     + I S E  E     +     +N   + +E+ ++   ++++    +
Sbjct: 2893 RRS-LLEILNSAADILINSSEADEDGIRDEKAGINQNMDAVTEELQAKTGSLEEMTQRLR 2951

Query: 793  QYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAI 852
            ++Q++ K+ E + E  +  L++ +   S       L+    K++ ++  L A   +V  +
Sbjct: 2952 EFQESFKNIEKKVEGAKHQLEIFDALGSQACSNKNLE----KLRAQQEVLQALEPQVDYL 3007

Query: 853  NRQRLQNLEFA-----LNLLRQQPEVEVTHETLQRNRPDSG-----------------VE 890
                   +E A      + L  Q EV        + R +SG                 V 
Sbjct: 3008 RNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEGIGQFHCRVR 3067

Query: 891  EAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESF 950
            E +    +LD+E +    +  +  S Q +I  +R    +  V++ ++         E S 
Sbjct: 3068 EMFSQLADLDDELDGMGAIGRDTDSLQSQIEDVRLFLNKIHVLKLDI---------EASE 3118

Query: 951  QQLQRTLAEEQHKNQL-LQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQ--- 1006
             + +  L EE   + L L+ ELEAL  Q   L +  +   QE +   + R+E    +   
Sbjct: 3119 AECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGK-ARQEQLELTLGRVEDFYRKLKG 3177

Query: 1007 ADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQ----- 1061
             ++     EE EAL+   G    EV ++ Q+   LA+ K   +E+V   + +KLQ     
Sbjct: 3178 LNDATTAAEEAEALQWVVG---TEVEIINQQ---LADFKMFQKEQVDPLQ-MKLQQVNGL 3230

Query: 1062 ---------NDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKI 1112
                      D  ++     ++E + R + L +K  + ++ LQ+ L    K +   E  +
Sbjct: 3231 GQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHCGKFQDALEPLL 3290

Query: 1113 T----VKEVLKVEKDAATE--------REVSDLTRQYEDE--------------AAKARA 1146
            +     +E++  +K  + E        +E   L R  +D               A  A  
Sbjct: 3291 SWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAEL 3350

Query: 1147 SQREK------------TELLRKIWALEEENAKVVVQEK-VREIVRP---------DPKA 1184
            + REK            TELL K  A +++   ++V  K   E   P            A
Sbjct: 3351 ADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLA 3410

Query: 1185 ESEVANLRLELVEQE-RKYRGAEEQLRSYQSELEALRRRGPQVE--VKEVTKEVIKYKTD 1241
             SE    +   ++Q+  +++  EE + ++ +++    + G  +        + V+  K D
Sbjct: 3411 NSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKID 3470

Query: 1242 PEMEK--ELQ-------RLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVV 1292
                +  E+Q        L ++ +   RL    ++E+     E++   D    V  K+  
Sbjct: 3471 SLQARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVE---DKLSSVFVKDFK 3527

Query: 1293 QEIL--QFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERV 1350
            Q++L  Q  +     EE+ +        +KK VD          Q  +  + L  +K+  
Sbjct: 3528 QDVLHRQHADHLALNEEIVN--------RKKNVD----------QAIKNGQAL--LKQTT 3567

Query: 1351 VQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERE- 1409
             ++ ++  E+  G++   +    +    LR +++ R    + Q    EL   L E+E E 
Sbjct: 3568 GEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYEELTGWLREVEEEL 3627

Query: 1410 --RQARREAEREVQRLQQRLAALEQEEAEAR---EKVTHTQKVVLQQDPQQAREHALLRL 1464
                 +     ++ + QQR   L++E  E R   + V    + +L+  P +ARE  L +L
Sbjct: 3628 ATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLDTVNEVSRALLELVPWRARE-GLDKL 3686

Query: 1465 QLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLE 1524
              +  +  + + +   + +    AA+++++  E+   +E   V   +T++++  L     
Sbjct: 3687 VSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYEQAADAELAWV--AETKRKLMALGPIRL 3744

Query: 1525 EESRSKRELDV------EVSRLEARLSELEFHNSK 1553
            E+ ++  +L V      ++ R +  + EL  H S+
Sbjct: 3745 EQDQTTAQLQVQKAFSIDIIRHKDSMDELFSHRSE 3779


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score =  247 bits (631), Expect = 6e-65
 Identities = 383/1789 (21%), Positives = 726/1789 (40%), Gaps = 367/1789 (20%)

Query: 153  SFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAK-DGDKEQNS---ELRAKYQKLLAASQAR 208
            ++G DL  V+  +  H   HN +      L K   D  + S   +L  +Y+ LL AS  R
Sbjct: 206  AWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFER 265

Query: 209  QQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEE 268
              HL  LQ+ +Q  + E+ W++   +  + YDWSD+N +   ++  +   +++ LE KE+
Sbjct: 266  MDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQ-LEVKEK 324

Query: 269  RINKLHSEGDQLLAAEHPGRNS---------------------IEAHMEAVHADWKEYLN 307
             +NKL  E DQL+  +HP  +                      I+ H++  +A + ++  
Sbjct: 325  ELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKE-NAAYFQFFE 383

Query: 308  LLICEESHLKYMED-----------------YHQFHEDVKDAQELL---RKVDSDLNQKY 347
                 E++LK ++D                   Q  E  K+ +++L   R+V + +N+  
Sbjct: 384  EAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSK 443

Query: 348  --------GPDFKDRYQIELLLRELDD---QEKVLDKYED-VVQGLQKRGQ--------- 386
                     PD++    I  +LR L D    +K++ K ++ +++   +R +         
Sbjct: 444  KIVQLKPRNPDYRSNKPI--ILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGV 501

Query: 387  -QVVPLKYRRETPLKPIPVEALCDFEGE-QGLISRGYSYTLQKNNGESWELMDSAGNKLI 444
              +VP       P  P+ V+  C  E   + +++      +   +  SW        K+ 
Sbjct: 502  DMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIR 561

Query: 445  APAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGS-------KRTLQQR-------YEV 490
            A  +  +      + +     L   Y+   + + GS       KR +Q +       Y+ 
Sbjct: 562  AMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQT 621

Query: 491  LKTENPG------------------------------DASDLQGRQLLAGLDKVASDLDR 520
            L  + PG                                +D Q   +L  L K+   ++ 
Sbjct: 622  LVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEH 681

Query: 521  QEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGS 580
             E  +T    P  +QG +   +  +  +LK++ N+   I     +     +  +    GS
Sbjct: 682  CEGRMTLKNLPLADQGSSHHITV-KINELKSVQNDSQAIAEVLNQL----KDMLANFRGS 736

Query: 581  GTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDT 640
                 L+  V    +K E++  + D     +     L +++ Q+ ++L  +E  L +++T
Sbjct: 737  EKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEET 796

Query: 641  VPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQ 700
            V      +++    L  +  +L  +KSLL  ++  LQ A+Q  S  + ++  +  DL + 
Sbjct: 797  VCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKF 856

Query: 701  EAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIP----SYEPQE 756
              +V +L  R+  + +Q++ R   L+       ++   +    ++L        S E  +
Sbjct: 857  GEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMK 916

Query: 757  TDSLSQMETKLKNQKNLLDEIASRE---QEVQKI---CANSQQYQQAVKDYELE----AE 806
                + +   L  QKNL  EI+ +    +EVQKI   CANS      +KDYEL+      
Sbjct: 917  FGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANS------IKDYELQLASYTS 970

Query: 807  KLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEV-------YAINRQRLQN 859
             L +LL++         KR  +QSP+  + +E A + A++ E+       Y    + L++
Sbjct: 971  GLETLLNIP-------IKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKS 1023

Query: 860  LEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELD------------------- 900
            LE   +L  +  ++EV  E L+  R D+  E   K  K LD                   
Sbjct: 1024 LE---DLKLKNTKIEVLEEELRLAR-DANSENCNK-NKFLDQNLQKYQAECSQFKAKLAS 1078

Query: 901  -EETERRRQLE------------NEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLE 947
             EE +R+ +L+             ++K   E+I  L  +   E   RK V  +      +
Sbjct: 1079 LEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQ--K 1136

Query: 948  ESFQQLQRTLAEEQHKNQLLQEELEALQL---------QLRALEQETRDGGQEY------ 992
              + QLQ+  A +  K  L  ++LE+ +          +LR L QE     +EY      
Sbjct: 1137 NDYDQLQK--ARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAK 1194

Query: 993  ---------------------VVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEV 1031
                                 + K  ++ E    + D+   LR +L+ L R+    + E+
Sbjct: 1195 VRNHYNEEMSNLRNKYETEINITKTTIK-EISMQKEDDSKNLRNQLDRLSRENRDLKDEI 1253

Query: 1032 LLLQQRVAALAEEKSRAQEKVTEKEVVK---LQNDPQLEAEYQQLQEDHQRQDQLREKQ- 1087
            + L   +    E++ RA+E   +++      +Q    LE E +Q+ +  + +D  R KQ 
Sbjct: 1254 VRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQ-QRSEDNARHKQS 1312

Query: 1088 -EEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATER-----EVSDLTRQYEDEA 1141
             EE    +QDK K  E ER  AE +   K   + E + +  R     E+  L  Q+E E 
Sbjct: 1313 LEEAAKTIQDKNK--EIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEI 1370

Query: 1142 AKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERK 1201
               + +  + T        +++E      + ++  + R +     E+  L+  L +    
Sbjct: 1371 NITKTTIHQLT--------MQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTEN 1422

Query: 1202 YRGAEEQLRSYQSELEALRRRGPQ--VEVKEV----TKEVIKY--------KTDPEMEKE 1247
             R  EE ++  ++    + +R  Q  VE+++V    T+E ++Y        KT  +  KE
Sbjct: 1423 LRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKE 1482

Query: 1248 LQRLREEIVDKTRLIERC--------DLEIYQLKKEIQALKDT--KPQVQTKEVV----- 1292
            ++RL+ +++DK     +C            Y L+K   +  +T  K +VQ +E+      
Sbjct: 1483 IERLK-QLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRID 1541

Query: 1293 ------------QEILQFQ--------EDPQTKEEVASLRAKLSEEQKKQVDLERERASQ 1332
                        Q+I +FQ        +  + +EE+  L+   SE+  K+  LE E    
Sbjct: 1542 YERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM 1601

Query: 1333 EEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRL 1392
               +  +  +++ + +++ Q  +V+   E  LR +     + +D  LR+  + + ELRRL
Sbjct: 1602 RRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQ----RDVLDGHLREKQRTQEELRRL 1657

Query: 1393 QRRRTELERQ-LEELERERQAR-----------------REAEREVQRLQQRLAALEQEE 1434
                  L RQ L+E E  +QA                   E++ E++RLQ     L +E 
Sbjct: 1658 SSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEH 1717

Query: 1435 AEAREKVTHTQKVVLQQDPQQAREHA---------LLRLQLEEEQHRRQLLEG------- 1478
                E++ + +  +   D ++ R  A          LR QL+   +R   L+G       
Sbjct: 1718 LMLEEELRNLR--LEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQR 1775

Query: 1479 ELETLRRKLAALEKAE-----------------VKEKVVLSESVQVEKGD------TEQE 1515
            E E LR+++   +K                   V+E+  L   ++V + D       E E
Sbjct: 1776 ERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDE 1835

Query: 1516 IQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNL 1575
            + R KS+LE E+R K+ L+ E  +++  L++ +   S+  + +  +  E  K + E+ +L
Sbjct: 1836 LNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSL 1895

Query: 1576 QLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKR 1624
            + E  RLQ+EI       R     +  ++ +  ++     +RE+D L++
Sbjct: 1896 RSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQ 1944



 Score =  140 bits (354), Expect = 8e-33
 Identities = 217/995 (21%), Positives = 439/995 (44%), Gaps = 148/995 (14%)

Query: 661  ELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVER 720
            +L+ + + +  +E+ L+ A+  +S   ++ +    +L++ +AE  +   +  +L    E 
Sbjct: 1026 DLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLE---EL 1082

Query: 721  RAQSLQSAKAAYEHFHRGHDHVLQFLVSIP--SYEPQ-ETDSLSQMETKLKNQKNLLDEI 777
            + Q+    K+A ++  + +  + +    I   +YE + E      +E +   QKN  D++
Sbjct: 1083 KRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQL 1142

Query: 778  A-SREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVK 836
              +R+ E + +     + ++A+K+ E E E+LR LL                Q   T+ +
Sbjct: 1143 QKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLL----------------QEEGTRKR 1186

Query: 837  EEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIR 896
            E E  LA K    Y      L+N        + + E+ +T  T++        +++  +R
Sbjct: 1187 EYENELA-KVRNHYNEEMSNLRN--------KYETEINITKTTIKEISMQKE-DDSKNLR 1236

Query: 897  KELDEETERRRQLENEVKSTQEEIWTLRNQ-------GPQESVVRKEVLKKVPDPVLEES 949
             +LD  +   R L++E+    + I     Q         Q+     E+++K     +E  
Sbjct: 1237 NQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELK 1296

Query: 950  FQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADE 1009
                QR+    +HK Q L+E  + +Q + + +E+   +  +E   K     E + ++   
Sbjct: 1297 QVMQQRSEDNARHK-QSLEEAAKTIQDKNKEIERLKAEFQEE--AKRRWEYENELSKVRN 1353

Query: 1010 VLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAE 1069
                 EE+ +L+ Q    E E+ + +  +  L  +K    E+ T     ++ N   L  E
Sbjct: 1354 --NYDEEIISLKNQF---ETEINITKTTIHQLTMQK----EEDTSGYRAQIDN---LTRE 1401

Query: 1070 YQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATERE 1129
             + L E+ +R      +  E L  +++ +   ++++A        K+ L+VE    T+  
Sbjct: 1402 NRSLSEEIKRLKNTLTQTTENLRRVEEDI---QQQKATGSEVSQRKQQLEVELRQVTQMR 1458

Query: 1130 VSDLTR--QYEDEAAKARASQREKTELLRKIW--------ALEEENAKVV--------VQ 1171
              +  R  Q  D+AAK    + ++ E L+++          LE+ENA++           
Sbjct: 1459 TEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKAN 1518

Query: 1172 EKVREIVRPDPKAESEVANLRL--ELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVK 1229
                E +      E E+  LR+  E V QER  +  ++ +  +Q+ L+ L     Q++ +
Sbjct: 1519 SSATETINKLKVQEQELTRLRIDYERVSQERTVK--DQDITRFQNSLKEL-----QLQKQ 1571

Query: 1230 EVTKEVIKYK-TDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQV-- 1286
            +V +E+ + K T  E   + ++L EE+    R ++   ++I  L ++++     K +   
Sbjct: 1572 KVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSED 1631

Query: 1287 ---QTKEVVQEILQFQEDPQTK-----EEVASLRAKLSEEQK--KQVDLERE---RASQE 1333
               Q ++V+   L+ ++  Q +      EV +LR +L +EQ+  KQ  L  E   +A ++
Sbjct: 1632 DLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIED 1691

Query: 1334 EQIARKE-----EELSRVKERVVQQEVVRYEEEPGLRAEASAF----AESIDVELRQIDK 1384
            +  +  E     E L  + E + ++ ++  EE   LR E        +E+   +   I +
Sbjct: 1692 KSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNATILE 1751

Query: 1385 LRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHT 1444
            LR++L+    R  EL+  + +L+RER+  R+   E+++ Q++  ALE        K   T
Sbjct: 1752 LRSQLQISNNRTLELQGLINDLQRERENLRQ---EIEKFQKQ--ALEASNRIQESKNQCT 1806

Query: 1445 QKVVLQQDPQQAREHALLRLQ-LEEEQHRRQLLEGELE----TLRRKLAALEKAEVKEKV 1499
            Q V       Q RE  L++++ LE+++ R Q LE EL     TL  +    ++ E +++ 
Sbjct: 1807 QVV-------QERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ 1859

Query: 1500 VLSESVQ--VEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARL------------- 1544
            + ++  Q   +    E+ I++++S  E+  R K  L  E+ RL+A +             
Sbjct: 1860 IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED 1919

Query: 1545 ------SELEFHNSKSSKELDFLREENHKLQLERQ 1573
                  S+LE   S+  +E+D LR+  +    E Q
Sbjct: 1920 STRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1954



 Score =  140 bits (354), Expect = 8e-33
 Identities = 289/1414 (20%), Positives = 567/1414 (40%), Gaps = 278/1414 (19%)

Query: 542  SAERAKDLKNITNELLRIEPE----KTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKY 597
            S ++  D KN+ N+L R+  E    K       ++ +QA              E   R  
Sbjct: 1225 SMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQA-------------TEQRRRAE 1271

Query: 598  EHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAA 657
            E+ LQ      E +     LE  L+Q  +  +  E++     ++ E+++ +  K +E+  
Sbjct: 1272 ENALQQKACGSEIMQKKQHLEIELKQVMQQRS--EDNARHKQSLEEAAKTIQDKNKEIER 1329

Query: 658  MACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQ-EAEVHKLGQRFNNLRQ 716
            +  E Q +     E E  L       S + + + E    L+ Q E E++      + L  
Sbjct: 1330 LKAEFQEEAKRRWEYENEL-------SKVRNNYDEEIISLKNQFETEINITKTTIHQLTM 1382

Query: 717  QVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDE 776
            Q E   +     +A  ++  R +  + + +  + +   Q T++L ++E  ++ QK    E
Sbjct: 1383 QKE---EDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSE 1439

Query: 777  IASREQEV--------QKICANSQQYQQA-------VKDYELEAEKLRSLLDL------- 814
            ++ R+Q++        Q     S +Y+Q+       ++D   E E+L+ L+D        
Sbjct: 1440 VSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKC 1499

Query: 815  ---ENGRSSHVS---KRARLQSPAT--KVKEEEAALAAKFTEVYAINRQR---------L 857
               EN R   V    ++A   +  T  K+K +E  L     +   ++++R          
Sbjct: 1500 LEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRF 1559

Query: 858  QNLEFALNLLRQQPEVEVTH-------------------ETLQRNRPDSGV--------- 889
            QN    L L +Q+ E E+                     E ++R+  +  +         
Sbjct: 1560 QNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQL 1619

Query: 890  EEAWKIRKELDEETERRRQLEN----EVKSTQEEIWTLRNQGPQESVVRKEVLKK----- 940
            E+A  ++K  +++  ++R + +    E + TQEE   LR    +   +R+++L++     
Sbjct: 1620 EQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEE---LRRLSSEVEALRRQLLQEQESVK 1676

Query: 941  ---VPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEV 997
               + +   +++ +   R+L E + + + LQ   E L  +   LE+E R+   EY     
Sbjct: 1677 QAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRR 1736

Query: 998  LRIEPDRAQADEVLQLREEL---------------------EALRR-----QKGAREA-- 1029
             R E D  +   +L+LR +L                     E LR+     QK A EA  
Sbjct: 1737 GRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASN 1796

Query: 1030 ---------------------EVLLLQQ---RVAALAEEKSRAQEKVTEKEVVK------ 1059
                                 ++ +L+Q   R+  L +E +RA+  +  +  VK      
Sbjct: 1797 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECE 1856

Query: 1060 ---LQND-PQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVK 1115
               +QND  Q + +Y + +E  ++ +  REK E E + L+ +++RL+ E    E +   K
Sbjct: 1857 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRK 1916

Query: 1116 -EVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE-KTE--------------LLRKIW 1159
             E    E  +  E E S   R+ +    +   S RE +TE              L +K+ 
Sbjct: 1917 LEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVT 1976

Query: 1160 ALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEAL 1219
            A++    +++ +  + ++++   K+  EVA+     +       GA    +   S +EA 
Sbjct: 1977 AMQLYECQLIDKTTLDKLLK-GKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAK 2035

Query: 1220 RRR--GPQ-----VEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLE---- 1268
            R++   P+     +E +  T  +I    DP   ++L       VD     +  D +    
Sbjct: 2036 RKKLISPESTVMLLEAQAATGGII----DPHRNEKLT------VDSAIARDLIDFDDRQQ 2085

Query: 1269 IYQLKKEIQALKDT------------KPQVQTKEVVQEILQFQ------EDPQTK----E 1306
            IY  +K I    D             K  +  +E    +L+ Q       DP       +
Sbjct: 2086 IYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPK 2145

Query: 1307 EVASLRAKLSEEQKKQVDLERERASQ-EEQIARKEEELSRVKERVVQQEVVRYEEEPGLR 1365
            +VA  R  +  +  + ++  R+      + + +K+    ++KER       R E   GL 
Sbjct: 2146 DVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERC------RIEPHTGLL 2199

Query: 1366 AEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQ 1425
               S    S+  +  +      EL      R     +LE  +       E  ++  +   
Sbjct: 2200 L-LSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSS 2258

Query: 1426 RLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRR 1485
             +A +  E  + +  +    K+ L + P  A       L+L E Q     +   +  LR 
Sbjct: 2259 CIAGIYNETTKQKLGIYEAMKIGLVR-PGTA-------LELLEAQAATGFIVDPVSNLRL 2310

Query: 1486 KLAALEKA-----EVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRL 1540
             +    K      E KEK++ +E  +   G  + E   + S  +  ++   E    +  L
Sbjct: 2311 PVEEAYKRGLVGIEFKEKLLSAE--RAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLL 2368

Query: 1541 EARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMT 1600
            EA+++     + K          E+H+L ++   +  +      E++   ++  D    T
Sbjct: 2369 EAQIATGGIIDPK----------ESHRLPVD---IAYKRGYFNEELSEILSDPSD---DT 2412

Query: 1601 VADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVV 1660
                  N +  L  L+ +    +R  KD++  +  L  +     V+  Q+    +R +V+
Sbjct: 2413 KGFFDPNTEENLTYLQLK----ERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVI 2468

Query: 1661 IHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVI-HDRKSGKKF 1719
            + P+T +E+S +EA++ GLID+  F +L  QEC+WEEI++ G +G + V+  DRK+G ++
Sbjct: 2469 VDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQY 2528

Query: 1720 SIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVS 1753
             I++A+  G +    +D+Y +  +S+ + A ++S
Sbjct: 2529 DIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMIS 2562



 Score =  120 bits (300), Expect = 2e-26
 Identities = 228/1039 (21%), Positives = 452/1039 (43%), Gaps = 191/1039 (18%)

Query: 586  LRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESS 645
            L TR  D  R    +L+ L+  + K      LE+ L+     LA   N  N +      +
Sbjct: 1006 LLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELR-----LARDANSENCN-----KN 1055

Query: 646  RVLDSKGQELAAMACELQAQKSLLGEVEQNLQ----AAKQCSSTLASRFQEHCPDLERQE 701
            + LD   Q+  A   + +A+ + L E+++  +    +AKQ              +L++  
Sbjct: 1056 KFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQ--------------NLDKCY 1101

Query: 702  AEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLV----SIPSYEPQET 757
             ++ +L ++   L  ++E   +  +S +  ++     +D + +       ++   + +  
Sbjct: 1102 GQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESE 1161

Query: 758  DSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQY-------------------QQAV 798
             ++ + E +++  + LL E  +R++E +   A  + +                   +  +
Sbjct: 1162 KAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTI 1221

Query: 799  KDYELEAE----KLRSLLDLENGRSSHVSKR------ARLQSPATKVKEEEAALAAKFTE 848
            K+  ++ E     LR+ LD  +  +  +         + LQ+   + + EE AL  K   
Sbjct: 1222 KEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACG 1281

Query: 849  VYAINRQRLQNLEFALN-LLRQQPEVEVTH----ETLQRNRPDSGVEEAWKIRKELDEET 903
               +  Q+ Q+LE  L  +++Q+ E    H    E   +   D   +E  +++ E  EE 
Sbjct: 1282 SEIM--QKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKN-KEIERLKAEFQEEA 1338

Query: 904  ERRRQLENEVKSTQ----EEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAE 959
            +RR + ENE+   +    EEI +L+NQ   E  + K  + ++     EE     +  +  
Sbjct: 1339 KRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQK-EEDTSGYRAQIDN 1397

Query: 960  EQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEA 1019
               +N+ L EE++ L+  L    +  R   ++        I+  +A   EV Q +++LE 
Sbjct: 1398 LTRENRSLSEEIKRLKNTLTQTTENLRRVEED--------IQQQKATGSEVSQRKQQLEV 1449

Query: 1020 -LRRQKGAREAEVLLLQQRV---AALAEEKSRAQEKVTEKEVVKLQNDPQL----EAEYQ 1071
             LR+    R  E +  +Q +   A   ++K++  E++ +  + K  ND +      A  Q
Sbjct: 1450 ELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQL-IDKETNDRKCLEDENARLQ 1508

Query: 1072 QLQEDHQRQDQLREK-------QEEELSFLQDKLKRLEKERAMAEGKIT-----VKEVLK 1119
            ++Q D Q+ +    +       QE+EL+ L+   +R+ +ER + +  IT     +KE L+
Sbjct: 1509 RVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE-LQ 1567

Query: 1120 VEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVV-VQEKVREIV 1178
            ++K    E E++ L R   +++ K R    E+ E +R+  +L+E+  K+  + +++ +  
Sbjct: 1568 LQKQKV-EEELNRLKRTASEDSCK-RKKLEEELEGMRR--SLKEQAIKITNLTQQLEQAS 1623

Query: 1179 RPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVE----------- 1227
                ++E ++   R  L    R+ +  +E+LR   SE+EALRR+  Q +           
Sbjct: 1624 IVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNE 1683

Query: 1228 -----VKEVTKEVIKYKTDPE---------------MEKELQRLREEIVDKTRLIERCDL 1267
                 +++ ++ + + K + E               +E+EL+ LR E  D  R     D 
Sbjct: 1684 HFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADS 1743

Query: 1268 E----IYQLKKEIQALKDTKPQVQ---------TKEVVQEILQFQEDPQTKEEVASLRAK 1314
            +    I +L+ ++Q   +   ++Q          + + QEI +FQ+  Q  E  AS R +
Sbjct: 1744 DKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQK--QALE--ASNRIQ 1799

Query: 1315 LSEEQKKQVDLERERA--------SQEEQIARKEEELSR----------VKERV------ 1350
             S+ Q  QV  ERE            + ++ R E+EL+R          VK+R+      
Sbjct: 1800 ESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQ 1859

Query: 1351 VQQEVVRYEEEPGLRAEASAFAESI-DVELRQIDKLRAELRRLQRRRTELE----RQLEE 1405
            +Q ++ +++ +   + EA    ES  +   R+ + LR+E+ RLQ     +E    R+LE+
Sbjct: 1860 IQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED 1919

Query: 1406 LERERQARREAER-----EVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHA 1460
              RE Q++ E ER     E+ +L+QR     +E     E    T K+V     ++     
Sbjct: 1920 STRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQ 1979

Query: 1461 LLRLQLEEEQHRRQLLEGE 1479
            L   QL ++    +LL+G+
Sbjct: 1980 LYECQLIDKTTLDKLLKGK 1998



 Score = 91.7 bits (226), Expect = 6e-18
 Identities = 124/569 (21%), Positives = 246/569 (43%), Gaps = 64/569 (11%)

Query: 1112 ITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQ 1171
            I +K  +         +E +D+  +Y +   ++    R  +E+L+ +  L+ +N K+ V 
Sbjct: 978  IPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVL 1037

Query: 1172 EKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEV 1231
            E+   + R    A SE  N    L +  +KY+    Q ++  + LE L+R+  +++ K  
Sbjct: 1038 EEELRLARD---ANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQA-ELDGKSA 1093

Query: 1232 TKEVIK-YKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKE 1290
             + + K Y    E+ +++ RL  EI D+ R  +  +    Q K +   L+  + Q + + 
Sbjct: 1094 KQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR-QCEKEN 1152

Query: 1291 VVQEILQFQEDPQTKE-EVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKER 1349
            +  + L+ ++  + KE E+  LR  L EE  ++ + E E A          EE+S ++ +
Sbjct: 1153 LGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHY---NEEMSNLRNK 1209

Query: 1350 VVQQEVVRYEEEPGLRA----EASAFAESIDVELR-QIDKLRAELRRLQR---------- 1394
                    YE E  +      E S   E     LR Q+D+L  E R L+           
Sbjct: 1210 --------YETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSIL 1261

Query: 1395 RRTELERQLEELERERQA-RREAEREVQRLQQRLAALEQEEAE--AREKVTHTQKVVLQQ 1451
            + TE  R+ EE   +++A   E  ++ Q L+  L  + Q+ +E  AR K +  +     Q
Sbjct: 1262 QATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQ 1321

Query: 1452 DPQQAREHALLRLQLEEEQHRRQLLEGELETLRR----KLAALEKAEVKEKVVLSESVQV 1507
            D  +  E   L+ + +EE  RR   E EL  +R     ++ +L+     E  +   ++  
Sbjct: 1322 DKNKEIER--LKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQ 1379

Query: 1508 EKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHK 1567
                 E++    ++ ++  +R  R L  E+ RL+  L++   +  +  +++   +    +
Sbjct: 1380 LTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSE 1439

Query: 1568 LQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSK 1627
            +   +Q L++E R++        T+ R   ++    S              LDD  +  +
Sbjct: 1440 VSQRKQQLEVELRQV--------TQMRTEESVRYKQS--------------LDDAAKTIQ 1477

Query: 1628 DKDLEIDELQKRLGSVAVKREQRENHLRR 1656
            DK+ EI+ L++ +      R+  E+   R
Sbjct: 1478 DKNKEIERLKQLIDKETNDRKCLEDENAR 1506



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 163/782 (20%), Positives = 315/782 (40%), Gaps = 105/782 (13%)

Query: 947  EESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQ 1006
            ++  +++Q    + Q   Q L  +L            E    G    V     IE +R  
Sbjct: 602  DDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNREN 661

Query: 1007 ADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQL 1066
              +   +  EL+ +RRQ    E  + L   +   LA++ S     V   E+  +QND Q 
Sbjct: 662  DKQETWMLMELQKIRRQIEHCEGRMTL---KNLPLADQGSSHHITVKINELKSVQNDSQA 718

Query: 1067 EAEYQQLQEDHQRQDQLRE-KQEEELSFLQDKL----KRLEKERAMAEGKITVKEVLKVE 1121
             AE       +Q +D L   +  E+  +LQ+++    ++LE    + +G +     ++  
Sbjct: 719  IAEVL-----NQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773

Query: 1122 KDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPD 1181
              A  + E  D+ + YE     AR ++ E   L      L++  A     +K++  +   
Sbjct: 774  LQAILQTE--DMLKVYE-----ARLTEEETVCL-----DLDKVEAYRCGLKKIKNDLN-- 819

Query: 1182 PKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVK--EVTKEVIKYK 1239
               +S +A ++ EL + ++ +    +Q   Y  +L     +  Q+  +   + K++    
Sbjct: 820  -LKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRL 878

Query: 1240 TDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQ 1299
             D  +EK++++LR    +     +     +Y  K+   +L+  K        V   L  Q
Sbjct: 879  WD--LEKQIKQLRNYRDNYQAFCKW----LYDAKRRQDSLESMK--FGDSNTVMRFLNEQ 930

Query: 1300 EDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYE 1359
            ++  +  E++  R K  E QK            E Q+A     L  +    +++ +++  
Sbjct: 931  KNLHS--EISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSP 988

Query: 1360 EEPGLRAEASAFAESIDVELRQIDKLR------AELRRLQRRRTELERQLEELERERQAR 1413
                L+  A   A  I++  R  D  R        L  L+ + T++E   EEL   R A 
Sbjct: 989  SGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDAN 1048

Query: 1414 REAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQ--DPQQAREH------------ 1459
             E   + + L Q L   + E ++ + K+   +++  Q   D + A+++            
Sbjct: 1049 SENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELN 1108

Query: 1460 ---ALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLS-ESVQVEKG--DTE 1513
                 L  ++E+E+ RR+ +E   +  +     L+KA   EK  L  + ++ EK   + E
Sbjct: 1109 EKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKE 1168

Query: 1514 QEIQRLKSSLEEESRSKRELDVEVSRLEARLSE----------LEFHNSKSS-KELDFLR 1562
             EI+RL+  L+EE   KRE + E++++    +E           E + +K++ KE+   +
Sbjct: 1169 YEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQK 1228

Query: 1563 EENHK--------LQLERQNLQLETRRLQSEINMAATETRDLRNMTVADS--GTNHDSRL 1612
            E++ K        L  E ++L+ E  RL   I  A  + R      +     G+    + 
Sbjct: 1229 EDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKK 1288

Query: 1613 WSLEREL------------------DDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHL 1654
              LE EL                  ++  +  +DK+ EI+ L+      A +R + EN L
Sbjct: 1289 QHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENEL 1348

Query: 1655 RR 1656
             +
Sbjct: 1349 SK 1350



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 160/925 (17%), Positives = 351/925 (37%), Gaps = 143/925 (15%)

Query: 10   KGKYSPTVQTRSISNKELSELIEQLQKNA-------DQVEKNIVDTEAKMQSDLARLQEG 62
            + KY   +     + KE+S   E   KN         +  +++ D   ++   + +  E 
Sbjct: 1207 RNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQ 1266

Query: 63   RQPEHRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK 122
            R+    +   QK   SE +      +  + + M+    D  A   + L+E    ++ K+K
Sbjct: 1267 RRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDN-ARHKQSLEEAAKTIQDKNK 1325

Query: 123  QIYRLAVK-EVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPH 181
            +I RL  + + + +  W    E +L K+ N      + L +    E NI    +     H
Sbjct: 1326 EIERLKAEFQEEAKRRWE--YENELSKVRNNYDEEIISLKNQFETEINITKTTI-----H 1378

Query: 182  LAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQ---------- 231
                  +E  S  RA+   L   +++  + +  L++ + + T  L  +++          
Sbjct: 1379 QLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGS 1438

Query: 232  ---QAKGRMQYDW---SDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQ------ 279
               Q K +++ +    +    +   R +Q  +   + ++ K + I +L    D+      
Sbjct: 1439 EVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRK 1498

Query: 280  LLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYM---------------EDYHQ 324
             L  E+     ++  ++  ++   E +N L  +E  L  +               +D  +
Sbjct: 1499 CLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITR 1558

Query: 325  FHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKR 384
            F   +K+ Q   +KV+ +LN+      +D  + + L  EL+   + L +    +  L ++
Sbjct: 1559 FQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQ 1618

Query: 385  GQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLI 444
             +Q   +K R E  L+            +Q  +  G+    Q+   E             
Sbjct: 1619 LEQASIVKKRSEDDLR------------QQRDVLDGHLREKQRTQEE------------- 1653

Query: 445  APAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQG 504
                                 L S+  ++R++    + +++Q +  L+ E+   A + + 
Sbjct: 1654 ------------------LRRLSSEVEALRRQLLQEQESVKQAH--LRNEHFQKAIEDKS 1693

Query: 505  RQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKT 564
            R     L++   +++R +     + +  L     +++      DL+   +E    + +K 
Sbjct: 1694 R----SLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSE---ADSDKN 1746

Query: 565  RSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEK-VDVANRLEKSLQQ 623
             +  E  + +Q    +  T  L+  + D  R+ E+L Q ++  Q++ ++ +NR+++S  Q
Sbjct: 1747 ATILELRSQLQI--SNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804

Query: 624  SWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCS 683
              +++   E+ L +   + +    L     EL      L+A+  +   +E   Q  +   
Sbjct: 1805 CTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDL 1864

Query: 684  STLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVL 743
            +   +++      + + E+E  K  +  N+LR ++ER    +   K   E   R      
Sbjct: 1865 NQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEI---KRIEERCRR------ 1915

Query: 744  QFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR----EQEVQKICANSQQYQQAVK 799
                     E    ++ SQ+ET+    +  +D++  R     +E Q  C  +    + V 
Sbjct: 1916 -------KLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVF 1968

Query: 800  D-----------YELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTE 848
            D           YE +     +L  L  G+ S     + +Q P  +     A  +A   E
Sbjct: 1969 DGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQ-PFLRGAGSIAGASASPKE 2027

Query: 849  VYAI---NRQRLQNLEFALNLLRQQ 870
             Y++    R++L + E  + LL  Q
Sbjct: 2028 KYSLVEAKRKKLISPESTVMLLEAQ 2052



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 21/85 (24%), Positives = 44/85 (51%), Gaps = 7/85 (8%)

Query: 1660 VIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQE---CDWEEISVKGPNGESSVIHDR--- 1713
            +IHP TG++LS ++A   G+ID +M  +L+  +     +E +  K     +  + ++   
Sbjct: 2660 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2719

Query: 1714 -KSGKKFSIEEALQSGRLTPAQYDR 1737
             ++G++F   + L  G + P  + R
Sbjct: 2720 YEAGQRFLEFQYLTGGLVDPEVHGR 2744


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
          Length = 1369

 Score =  243 bits (619), Expect = 2e-63
 Identities = 198/826 (23%), Positives = 370/826 (44%), Gaps = 114/826 (13%)

Query: 27   LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86
            L  ++ +LQ  A   E+ +   +A +QSD+  L  G+ P+      + +  ++ ++ +L 
Sbjct: 527  LQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLF 586

Query: 87   ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK------------QIYRLAVKEVD- 133
             D    K  +HPQG+ +   + +L ER+  +R ++             Q+ ++ ++ V  
Sbjct: 587  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 646

Query: 134  -PQVNWAAL---------VEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLA 183
             P++  + L         VEE   +++   +G DLP V+ Q+  H   H  ++     + 
Sbjct: 647  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIE 706

Query: 184  KDGDKEQN-------------SELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD 230
            +    E                 L  +Y KLL +S+AR + L SL  ++   T EL WL+
Sbjct: 707  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 766

Query: 231  QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290
            ++ +  + +DWSDRN +  +++  Y   + R LE KE++I +L + GD+LL  +HP R +
Sbjct: 767  EKEEEEVGFDWSDRNTNMTAKKESYSALM-RELELKEKKIKELQNAGDRLLREDHPARPT 825

Query: 291  IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD 350
            +E+   A+   W   L L  C E+HLK    Y QF  DV++A+  L+K+   L +K   D
Sbjct: 826  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCD 885

Query: 351  FKDRY-QIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-PLK-PIPVEAL 407
                  ++E LL++  D+++ L++Y+  + GL KR + VV LK R    P++  +P+ A+
Sbjct: 886  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 945

Query: 408  CDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPPTDPEALALADSL 466
            CD++  +  + +G    L      S W+++ S+G++   P+VCF++PP + E       L
Sbjct: 946  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRL 1005

Query: 467  GSQYRS---------------------------VRQKAAGSKRTL---QQRYEVLKTENP 496
             +Q+++                           +R  +  + RTL   +QR  +   E  
Sbjct: 1006 EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 1065

Query: 497  -----GDASDLQG--------------------RQLLAGLDKVASDLDRQEKAITGI--- 528
                  D+ D  G                    +QLL  L++ A +  R ++ I+ +   
Sbjct: 1066 YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 1125

Query: 529  --------------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI 574
                          LR PL++  A ++ A+R  + +    E+  +     R +AE E  +
Sbjct: 1126 RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1184

Query: 575  QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH 634
                 S   P LR+ +E T  K E +  L  +  EK+   + + +  Q + E+L  HE  
Sbjct: 1185 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1244

Query: 635  LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC 694
            L +   VP +   L++    L  +  + +AQ+     +   L+ A++    L  R  E  
Sbjct: 1245 LKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1304

Query: 695  PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHD 740
             ++ER    V +L +R+  +  Q + R + L+       ++    D
Sbjct: 1305 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESAD 1350



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 68/264 (25%), Positives = 106/264 (40%), Gaps = 35/264 (13%)

Query: 1245 EKELQRLREEIVDKTRLIERCDLE-IYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQ 1303
            E   QR   E+ D    +E C+   +++L+  +    D +P    +E  Q I + Q+   
Sbjct: 1112 ESRCQRCISELKDIRLQLEACETRTVHRLRLPL----DKEP---ARECAQRIAEQQKAQA 1164

Query: 1304 TKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEE--- 1360
              E +    A+LS E +K + L     S      R E EL+  K   V+     Y E   
Sbjct: 1165 EVEGLGKGVARLSAEAEKVLALPEP--SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK 1222

Query: 1361 ------------EPGLRAEASAF--AESIDVELRQIDKLRAELRRLQRRRTELERQLEEL 1406
                        E  LRA       A+++   L +++  +A L++L   R + E Q    
Sbjct: 1223 TISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKL---RAQAEAQQPTF 1279

Query: 1407 ERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHT----QKVVLQQDPQQAREHALL 1462
            +  R   R A+   +RLQQR    + E    RE+V       Q V+ Q D +Q RE   L
Sbjct: 1280 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQ-RELEQL 1338

Query: 1463 RLQLEEEQHRRQLLEGELETLRRK 1486
              QL   +     L   L+  RR+
Sbjct: 1339 GRQLRYYRESADPLGAWLQDARRR 1362



 Score = 39.7 bits (91), Expect = 0.026
 Identities = 218/1082 (20%), Positives = 396/1082 (36%), Gaps = 244/1082 (22%)

Query: 34   LQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLEADAAIAK 93
            ++K   ++   I++ E +++S+  RL+           LQ+++        L+ +A + +
Sbjct: 499  VEKEWGKLHVAILEREKQLRSEFERLE----------CLQRIVTK------LQMEAGLCE 542

Query: 94   HMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKLDKLNNQS 153
               H    ++  DIR L        GK  Q      +++D           K D +    
Sbjct: 543  EQLHQADALLQSDIRLLAA------GKVPQRAGEVERDLD-----------KADSMIRLL 585

Query: 154  FGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLS 213
            F     L D +  +    +  V  +   L           LR K      A+Q  Q  L 
Sbjct: 586  FNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI---RTEYNLRLKAGVAAPATQVAQVTLQ 642

Query: 214  SLQ-------DYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENF--INRNLE 264
            S+Q         ++   + L W+++    + + D ++  +D PS   Q  +   +++++E
Sbjct: 643  SVQRRPELEDSTLRYLQDLLAWVEEN---QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 699

Query: 265  AKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQ 324
              + +I +  S+  QL  A           ++       +Y  LL   ++ L+ +E  H 
Sbjct: 700  EFQAKIERARSDEGQLSPATRGAYRDCLGRLDL------QYAKLLNSSKARLRSLESLHS 753

Query: 325  FHEDVKDAQELLRKVDSDLNQKYGPDFKDRY--------QIELLLRELDDQEKVLDKYED 376
            F   V  A + L  ++    ++ G D+ DR             L+REL+ +EK + +   
Sbjct: 754  F---VAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKE--- 807

Query: 377  VVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWELM 436
                LQ  G +++    R + P +P         E  Q  +   +S+ LQ          
Sbjct: 808  ----LQNAGDRLL----REDHPARPT-------VESFQAALQTQWSWMLQ---------- 842

Query: 437  DSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENP 496
                       +C  I     EA    ++   Q+ S  ++A G  + LQ   E L+ +N 
Sbjct: 843  -----------LCCCI-----EAHLKENAAYFQFFSDVREAEGQLQKLQ---EALRRKNS 883

Query: 497  GDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNEL 556
             D S    R     L+ +  D                      QD  E+  + K   + L
Sbjct: 884  CDRSATVTR-----LEDLLQD---------------------AQDEKEQLNEYKGHLSGL 917

Query: 557  LRIEPEKTRSTAEGEAFIQALPGSGTTPLLRT----RVEDTNRKYEHLLQLLDLAQEKVD 612
             +    + ++  + +    A P  G  PLL      +VE T  K +   QL+  AQ    
Sbjct: 918  AK----RAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC-QLVGPAQPS-- 970

Query: 613  VANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEV 672
                        W++L++       +  VP    ++    QE+      L+AQ   L  +
Sbjct: 971  -----------HWKVLSSS----GSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTL 1015

Query: 673  EQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAY 732
               L       S LA +       L R  +        F  L+ + +R  Q+L S +  Y
Sbjct: 1016 WHQLHV--DMKSLLAWQSLRRDVQLIRSWSLA-----TFRTLKPEEQR--QALHSLELHY 1066

Query: 733  EHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQ 792
            + F R       F         +E  S S    +L      L++ A  E   Q+  +  +
Sbjct: 1067 QAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQS---LEQGAQEESRCQRCISELK 1123

Query: 793  QYQQAVKDYELEA-EKLRSLLDLENGR--SSHVSKRARLQSPATKVKEEEAALAAKFTEV 849
              +  ++  E     +LR  LD E  R  +  ++++ + Q+    + +  A L+A+  +V
Sbjct: 1124 DIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKV 1183

Query: 850  YAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQL 909
             A     L     A   LR   E+E+T   L++ R  S +              E+ + +
Sbjct: 1184 LA-----LPEPSPAAPTLRS--ELELTLGKLEQVRSLSAIY------------LEKLKTI 1224

Query: 910  ENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQE 969
               ++ TQ     LR          +E LK+          Q +  TL E +      + 
Sbjct: 1225 SLVIRGTQGAEEVLR--------AHEEQLKEA---------QAVPATLPELE----ATKA 1263

Query: 970  ELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREA 1029
             L+ L+ Q  A +Q T D                 A  DE+   +E  E L+++ G R+ 
Sbjct: 1264 SLKKLRAQAEA-QQPTFD-----------------ALRDELRGAQEVGERLQQRHGERDV 1305

Query: 1030 EVLLLQQRVAALAE--EKSRAQEKVTEKEVVKLQNDPQLEAEYQQ-----LQEDHQRQDQ 1082
            EV   ++RVA L E  +   AQ  V ++E+ +L    +   E        LQ+  +RQ+Q
Sbjct: 1306 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1365

Query: 1083 LR 1084
            ++
Sbjct: 1366 IQ 1367



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 49/253 (19%), Positives = 113/253 (44%), Gaps = 22/253 (8%)

Query: 1185 ESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEM 1244
            E E   L + ++E+E+       QLRS    LE L+R   +++++    E   ++ D  +
Sbjct: 500  EKEWGKLHVAILEREK-------QLRSEFERLECLQRIVTKLQMEAGLCEEQLHQADALL 552

Query: 1245 EKELQ-----RLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQ 1299
            + +++     ++ +   +  R +++ D  I  L  ++Q LKD +   Q +++ + + +  
Sbjct: 553  QSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR-HPQGEQMYRRVYRLH 611

Query: 1300 EDPQTKEEVASLRAKLSEEQKKQVDLERERASQEE-QIARKEEELSRVKERVVQQEVVRY 1358
                  E + ++R + +   K  V     + +Q   Q  ++  EL     R + Q+++ +
Sbjct: 612  ------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYL-QDLLAW 664

Query: 1359 EEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAER 1418
             EE   R + + +   +     Q+   R   + ++  + ++ER   +  +   A R A R
Sbjct: 665  VEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATRGAYR 724

Query: 1419 E-VQRLQQRLAAL 1430
            + + RL  + A L
Sbjct: 725  DCLGRLDLQYAKL 737



 Score = 32.0 bits (71), Expect = 5.4
 Identities = 53/215 (24%), Positives = 81/215 (37%), Gaps = 52/215 (24%)

Query: 1413 RREAEREV-------QRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQ 1465
            R  AERE        Q+L Q L    QEE+  +  ++  + + LQ +  + R    LRL 
Sbjct: 1084 RLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLP 1143

Query: 1466 LEEEQHR--------RQLLEGELETLRRKLAALEKAEVKEKVVLSE-------------- 1503
            L++E  R        +Q  + E+E L + +A L  AE ++ + L E              
Sbjct: 1144 LDKEPARECAQRIAEQQKAQAEVEGLGKGVARL-SAEAEKVLALPEPSPAAPTLRSELEL 1202

Query: 1504 ------------SVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHN 1551
                        ++ +EK  T   + R     EE  R+  E   E   + A L ELE   
Sbjct: 1203 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1262

Query: 1552 SKSSK----------ELDFLREENHKLQLERQNLQ 1576
            +   K            D LR+E    Q   + LQ
Sbjct: 1263 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQ 1297



 Score = 31.2 bits (69), Expect = 9.3
 Identities = 28/88 (31%), Positives = 41/88 (46%), Gaps = 14/88 (15%)

Query: 1406 LERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQD---------PQQA 1456
            LERE+Q R E ER      QR+    Q EA   E+  H    +LQ D         PQ+A
Sbjct: 511  LEREKQLRSEFER--LECLQRIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRA 568

Query: 1457 REHALLRLQLEEEQHRRQLLEGELETLR 1484
             E   +   L++     +LL  +++TL+
Sbjct: 569  GE---VERDLDKADSMIRLLFNDVQTLK 593


>gi|58530842 desmoplakin isoform II [Homo sapiens]
          Length = 2272

 Score =  224 bits (570), Expect = 7e-58
 Identities = 391/1838 (21%), Positives = 751/1838 (40%), Gaps = 317/1838 (17%)

Query: 153  SFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAK-DGDKEQNS---ELRAKYQKLLAASQAR 208
            ++G DL  V+  +  H   HN +      L K   D  + S   +L  +Y+ LL AS  R
Sbjct: 206  AWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFER 265

Query: 209  QQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEE 268
              HL  LQ+ +Q  + E+ W++   +  + YDWSD+N +   ++  +   +++ LE KE+
Sbjct: 266  MDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQ-LEVKEK 324

Query: 269  RINKLHSEGDQLLAAEHPGRNS---------------------IEAHMEAVHADWKEYLN 307
             +NKL  E DQL+  +HP  +                      I+ H++  +A + ++  
Sbjct: 325  ELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKE-NAAYFQFFE 383

Query: 308  LLICEESHLKYMED-----------------YHQFHEDVKDAQELL---RKVDSDLNQKY 347
                 E++LK ++D                   Q  E  K+ +++L   R+V + +N+  
Sbjct: 384  EAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKILEYKRQVQNLVNKSK 443

Query: 348  --------GPDFKDRYQIELLLRELDD---QEKVLDKYED-VVQGLQKRGQ--------- 386
                     PD++    I  +LR L D    +K++ K ++ +++   +R +         
Sbjct: 444  KIVQLKPRNPDYRSNKPI--ILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGV 501

Query: 387  -QVVPLKYRRETPLKPIPVEALCDFEGE-QGLISRGYSYTLQKNNGESWELMDSAGNKLI 444
              +VP       P  P+ V+  C  E   + +++      +   +  SW        K+ 
Sbjct: 502  DMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIR 561

Query: 445  APAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGS-------KRTLQQR-------YEV 490
            A  +  +      + +     L   Y+   + + GS       KR +Q +       Y+ 
Sbjct: 562  AMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQT 621

Query: 491  LKTENPG------------------------------DASDLQGRQLLAGLDKVASDLDR 520
            L  + PG                                +D Q   +L  L K+   ++ 
Sbjct: 622  LVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETNRENDKQETWMLMELQKIRRQIEH 681

Query: 521  QEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGS 580
             E  +T    P  +QG +   +  +  +LK++ N+   I     +     +  +    GS
Sbjct: 682  CEGRMTLKNLPLADQGSSHHITV-KINELKSVQNDSQAIAEVLNQL----KDMLANFRGS 736

Query: 581  GTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDT 640
                 L+  V    +K E++  + D     +     L +++ Q+ ++L  +E  L +++T
Sbjct: 737  EKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEET 796

Query: 641  VPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQ 700
            V      +++    L  +  +L  +KSLL  ++  LQ A+Q  S  + ++  +  DL + 
Sbjct: 797  VCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKF 856

Query: 701  EAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIP----SYEPQE 756
              +V +L  R+  + +Q++ R   L+       ++   +    ++L        S E  +
Sbjct: 857  GEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMK 916

Query: 757  TDSLSQMETKLKNQKNLLDEIASRE---QEVQKI---CANSQQYQQAVKDYELEAEK--- 807
                + +   L  QKNL  EI+ +    +EVQKI   CANS      +KDYEL+      
Sbjct: 917  FGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANS------IKDYELQLASYTS 970

Query: 808  -LRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEV-------YAINRQRLQN 859
             L +LL++         KR  +QSP+  + +E A + A++ E+       Y    + L++
Sbjct: 971  GLETLLNIP-------IKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKS 1023

Query: 860  LEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELD------------------- 900
            LE   +L  +  ++EV  E L+  R D+  E   K  K LD                   
Sbjct: 1024 LE---DLKLKNTKIEVLEEELRLAR-DANSENCNK-NKFLDQNLQKYQAECSQFKAKLAS 1078

Query: 901  -EETERRRQLEN------------EVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLE 947
             EE +R+ +L+             ++K   E+I  L  +   E   RK V  +      +
Sbjct: 1079 LEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQ--K 1136

Query: 948  ESFQQLQRTLAEEQHKNQLLQEELEALQL---------QLRALEQETRDGGQEY---VVK 995
              + QLQ+  A +  K  L  ++LE+ +          +LR L QE     +EY   + K
Sbjct: 1137 NDYDQLQK--ARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAK 1194

Query: 996  EVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQ---RVAALAEEKSRAQEKV 1052
               RI+  + Q  +V+Q RE L    +     +A +  L+    R  +  E ++R ++++
Sbjct: 1195 ASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL 1254

Query: 1053 TEKEVVKLQND-PQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGK 1111
             E E  ++QND  Q + +Y + +E  ++ +  REK E E + L+ +++RL+ E    E +
Sbjct: 1255 -ECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEER 1313

Query: 1112 ITVK-EVLKVEKDAATEREVSDLTRQYEDEAAKARASQRE-KTE--------------LL 1155
               K E    E  +  E E S   R+ +    +   S RE +TE              L 
Sbjct: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373

Query: 1156 RKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSE 1215
            +K+ A++    +++ +  + ++++   K+  EVA+     +       GA    +   S 
Sbjct: 1374 KKVTAMQLYECQLIDKTTLDKLLK-GKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSL 1432

Query: 1216 LEALRRR--GPQ-----VEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLE 1268
            +EA R++   P+     +E +  T  +I    DP   ++L       VD     +  D +
Sbjct: 1433 VEAKRKKLISPESTVMLLEAQAATGGII----DPHRNEKLT------VDSAIARDLIDFD 1482

Query: 1269 ----IYQLKKEIQALKDT------------KPQVQTKEVVQEILQFQ------EDPQTK- 1305
                IY  +K I    D             K  +  +E    +L+ Q       DP    
Sbjct: 1483 DRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSV 1542

Query: 1306 ---EEVASLRAKLSEEQKKQVDLERERASQ-EEQIARKEEELSRVKERVVQQEVVRYEEE 1361
               ++VA  R  +  +  + ++  R+      + + +K+    ++KER       R E  
Sbjct: 1543 FLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERC------RIEPH 1596

Query: 1362 PGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQ 1421
             GL    S    S+  +  +      EL      R     +LE  +       E  ++  
Sbjct: 1597 TGLLL-LSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFL 1655

Query: 1422 RLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELE 1481
            +    +A +  E  + +  +    K+ L + P  A       L+L E Q     +   + 
Sbjct: 1656 QGSSCIAGIYNETTKQKLGIYEAMKIGLVR-PGTA-------LELLEAQAATGFIVDPVS 1707

Query: 1482 TLRRKLAALEKA-----EVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVE 1536
             LR  +    K      E KEK++ +E  +   G  + E   + S  +  ++   E    
Sbjct: 1708 NLRLPVEEAYKRGLVGIEFKEKLLSAE--RAVTGYNDPETGNIISLFQAMNKELIEKGHG 1765

Query: 1537 VSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDL 1596
            +  LEA+++     + K          E+H+L ++   +  +      E++   ++  D 
Sbjct: 1766 IRLLEAQIATGGIIDPK----------ESHRLPVD---IAYKRGYFNEELSEILSDPSD- 1811

Query: 1597 RNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRR 1656
               T      N +  L  L+ +    +R  KD++  +  L  +     V+  Q+    +R
Sbjct: 1812 --DTKGFFDPNTEENLTYLQLK----ERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKR 1865

Query: 1657 SIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVI-HDRKS 1715
             +V++ P+T +E+S +EA++ GLID+  F +L  QEC+WEEI++ G +G + V+  DRK+
Sbjct: 1866 RVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKT 1925

Query: 1716 GKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVS 1753
            G ++ I++A+  G +    +D+Y +  +S+ + A ++S
Sbjct: 1926 GSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMIS 1963



 Score = 33.1 bits (74), Expect = 2.4
 Identities = 21/85 (24%), Positives = 44/85 (51%), Gaps = 7/85 (8%)

Query: 1660 VIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQE---CDWEEISVKGPNGESSVIHDR--- 1713
            +IHP TG++LS ++A   G+ID +M  +L+  +     +E +  K     +  + ++   
Sbjct: 2061 IIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLP 2120

Query: 1714 -KSGKKFSIEEALQSGRLTPAQYDR 1737
             ++G++F   + L  G + P  + R
Sbjct: 2121 YEAGQRFLEFQYLTGGLVDPEVHGR 2145


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  184 bits (466), Expect = 9e-46
 Identities = 362/1650 (21%), Positives = 673/1650 (40%), Gaps = 231/1650 (14%)

Query: 20   RSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSE 79
            RS   +EL++ +E L++   ++E  + + + +M++  A+ +E R  +      Q  L++E
Sbjct: 866  RSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERT-QAESALCQMQLETE 924

Query: 80   K--------LLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTN------LRGKHKQIY 125
            K        LL   +  A  ++ ++  + DM    +++LKE+ T       L+   +++ 
Sbjct: 925  KERVSLLETLLQTQKELADASQQLERLRQDM---KVQKLKEQETTGILQTQLQEAQRELK 981

Query: 126  RLAVKEVDP----QVNWAALVEEKLD------KLNNQSFGTD--LPLVDHQVEEHNIFHN 173
              A +  D     Q   ++L+++K+D       L +Q    D    LV+ +V+E      
Sbjct: 982  EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQ 1041

Query: 174  EVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQA---RQQHLSSLQDYMQRCTNELYWLD 230
            E   I   L ++        L  K Q+LL   +A   RQQ LS+L+  MQ    E   L 
Sbjct: 1042 EYNRIQKELERE-KASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELS 1100

Query: 231  QQAKGRMQYDWSDRNLDYPSRRRQY----------ENFINRNLEAKEE-------RINKL 273
             Q +  ++ +  ++  D+ ++  Q           E  +  +L A+E        R+   
Sbjct: 1101 AQME-LLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRST 1159

Query: 274  HSEGDQLLAAEHPGRNS-IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQ----FHED 328
             S+ + L A + PG  +  +A + ++++  ++ L  +      L    D          D
Sbjct: 1160 ESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPD 1219

Query: 329  VKDAQELLRK-----------VDSDLNQKYGPDFKD-------RYQIELLLRELDDQEKV 370
               A+ L ++           V S L++ +   +K        R Q++ L   L D E  
Sbjct: 1220 QNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAE 1279

Query: 371  LDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNG 430
              +    +Q LQ++  Q    K + E     +  E +   E    L SR     LQ+   
Sbjct: 1280 KSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEA 1339

Query: 431  ESW-ELMDSAGNKLIAPAVCFVIPPTDPEALALADS-LGSQYRSVRQKAAGSKRTLQ-QR 487
            +   EL+ +A   L A          +  A A A   L    R+ R         ++ +R
Sbjct: 1340 QGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESER 1399

Query: 488  YEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAK 547
                  +  G+    QG+ L   L  +   L  +E+ +        E  R      E+ +
Sbjct: 1400 ERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEV--------ETLRGQIQELEKQR 1451

Query: 548  DLKNITNELLRIEPEKTRSTAE-GEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDL 606
            +++    ELL ++ +K     +  +  IQ L             E      EHL   +  
Sbjct: 1452 EMQKAALELLSLDLKKRNQEVDLQQEQIQEL-------------EKCRSVLEHLPMAVQE 1498

Query: 607  AQEKVDVANR----LEKSLQQSWELLATHENHLNQDDTVPESSR--VLDSKGQ--ELAAM 658
             ++K+ V       LEK  +    +L      L + D + ES R  V D K Q   L  +
Sbjct: 1499 REQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECL 1558

Query: 659  ACELQ-------AQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRF 711
            A EL+        Q+ L+ E+E   +  +   + L    +E   +L+ Q +++H L    
Sbjct: 1559 ALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHS 1618

Query: 712  NNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQK 771
              L ++++ R Q ++S +   E   R  +H+ Q L         + + +  +E +   Q 
Sbjct: 1619 TVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQT 1678

Query: 772  NLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLD--LENGRSSHVSKRARLQ 829
             +L+E             + +Q + ++++   E    R L+    E G+    ++R  L+
Sbjct: 1679 KILEE-------------DLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLE 1725

Query: 830  SPATKVKEEEAALAAKFTEVYAIN------RQRLQNL-----EFALNLLRQQPEVEVTHE 878
                 ++++E  +  +   ++ +        Q+LQ L     E +L L +++ E+ V  +
Sbjct: 1726 HMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQ 1785

Query: 879  TLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKE-- 936
             LQ  R    ++E   ++ +LDE      Q + E+++ Q+E    + QG +E V  K   
Sbjct: 1786 QLQEAREQGELKEQ-SLQSQLDEAQRALAQRDQELEALQQE--QQQAQGQEERVKEKADA 1842

Query: 937  ---VLKKVPDPVLE---------ESFQQLQRTLAEEQHKNQLLQEELEALQLQLR----- 979
                L++    + E         E  ++L+  LA E  + Q L+E L  L+ + R     
Sbjct: 1843 LQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKA 1902

Query: 980  --ALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLR-EELEALRRQKGAREAEVLLLQQ 1036
              AL+Q+  +  QE+ V E   ++    QA  VL+ R +ELEALR +  +   +    + 
Sbjct: 1903 LLALQQQCAEQAQEHEV-ETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARA 1961

Query: 1037 RVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQD 1096
            R  AL E   +A   +  KE              Q L E    Q +L    E   + LQ 
Sbjct: 1962 RAEALQEALGKAHAALQGKE--------------QHLLE----QAELSRSLEASTATLQA 2003

Query: 1097 KLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLR 1156
             L   +      E  + ++E    ++D   + +V  L +       + R  Q+E+ +LL 
Sbjct: 2004 SLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELR-HQQEREQLLE 2062

Query: 1157 KIWALEEENAKV-----VVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRS 1211
            K  A   +   +     + QE+  E +R        V  L+L L ++E++     E    
Sbjct: 2063 KSLAQRVQENMIQEKQNLGQEREEEEIR---GLHQSVRELQLTLAQKEQEILELRE--TQ 2117

Query: 1212 YQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQ 1271
             ++ LEAL        ++E + ++     +P +++EL+RL+  +    R  E  ++E  +
Sbjct: 2118 QRNNLEALPHSHKTSPMEEQSLKL--DSLEPRLQRELERLQAAL----RQTEAREIEWRE 2171

Query: 1272 LKKEIQ-ALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLE-RER 1329
              +++  +L  TK  V + + V   LQ           AS+  + SE+Q+ Q +LE   R
Sbjct: 2172 KAQDLALSLAQTKASVSSLQEVAMFLQ-----------ASVLERDSEQQRLQDELELTRR 2220

Query: 1330 ASQEEQI----ARKEEEL-SRVKERVVQQEVVRYEEEPGLRA-EASAFAESIDVELRQID 1383
            A ++E++    A    EL SR ++ V   EV   E EP     E  ++ + ++   + + 
Sbjct: 2221 ALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVA 2280

Query: 1384 KLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTH 1443
            +L  +  RLQR   +L   LE++ERE   RR+ +RE  R  Q   +LE  +A A      
Sbjct: 2281 RLEIDRSRLQRHNVQLRSTLEQVERE---RRKLKREAMRAAQ-AGSLEISKATASSPTQQ 2336

Query: 1444 TQKVVLQQD----PQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKV 1499
              +     D     +  +E  LL+ QL  E+ ++Q          R+LA L  +     +
Sbjct: 2337 DGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLL 2396

Query: 1500 VLSESVQVEKGDTEQEIQRLKSSLEEESRS 1529
             ++++   E    E E +RL  SL +   S
Sbjct: 2397 AVAQA--PEATVLEAETRRLDESLTQSLTS 2424



 Score =  165 bits (417), Expect = 4e-40
 Identities = 290/1339 (21%), Positives = 568/1339 (42%), Gaps = 228/1339 (17%)

Query: 485  QQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAE 544
            ++R E L  +N    + LQ  +  AG +  A   D QE+     ++  L + R  Q++A 
Sbjct: 651  EKRREALWEKNTHLEAQLQKAEE-AGAELQADLRDIQEEKEE--IQKKLSESRHQQEAA- 706

Query: 545  RAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLL-QL 603
                L+ +  E  R E    R+  E EA ++          L  R++   R  + L  QL
Sbjct: 707  -TTQLEQLHQEAKRQEEVLARAVQEKEALVREKAA------LEVRLQAVERDRQDLAEQL 759

Query: 604  LDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQ 663
              L+  K  + + L ++ QQ+  +  T      Q  TV ++  V+     E+  +  EL 
Sbjct: 760  QGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQG---EVRCLKLELD 816

Query: 664  AQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEA----EVHKLGQRFNNLR---- 715
             ++S   + EQ   AA +    LA   QE    LE+Q+A    EV++L +++   R    
Sbjct: 817  TERS---QAEQERDAAAR---QLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQ 870

Query: 716  QQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDS-LSQMETKLKNQK-NL 773
            Q++ +  +SL+  K   E   +     ++ + +    E  + +S L QM+ + + ++ +L
Sbjct: 871  QELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSL 930

Query: 774  LDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLL---------DLENGRSSHVSK 824
            L+ +   ++E+       ++ +Q +K  +L+ ++   +L         +L+     H   
Sbjct: 931  LETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDD 990

Query: 825  RARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNR 884
             A LQ  ++ + +++  L  +  ++    + +L   + +  L+ Q+ + E   ET + NR
Sbjct: 991  LAALQEESSSLLQDKMDLQKQVEDL----KSQLVAQDDSQRLVEQEVQ-EKLRETQEYNR 1045

Query: 885  PDSGVE-EAWKIRKELDEETERRRQLENEVKSTQEEIWTLRN-----QGPQESV------ 932
                +E E   +   L E+ +R   L+      Q+E+  LR      QG Q+ +      
Sbjct: 1046 IQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMEL 1105

Query: 933  VRKEVLKKVPDPVLEESF------------QQLQRTLAEEQHKNQLLQEELEALQLQLRA 980
            +R+EV +K  D + +E+             QQL+ +L  ++ K   LQ  L + + QL A
Sbjct: 1106 LRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEA 1165

Query: 981  LEQETRDGGQEYVVKE-------------------------------VLRIEPDRAQADE 1009
            L  E + G Q     +                               V  +EPD+  A  
Sbjct: 1166 LAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARS 1225

Query: 1010 VLQLREELEALRRQKGAREAEVL-----LLQQRVAALAEEKSRAQEKVTEKEVVKLQNDP 1064
            + +    L AL  +  A     L       QQ    L ++  + +E++T+ E  K Q   
Sbjct: 1226 LFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHT 1285

Query: 1065 QLEAEYQQLQEDHQRQDQLREKQE----------EELSFLQDKLKRLEKERAMAEGKITV 1114
            +L+   +QL ++ + + +   KQ           E ++ LQ +L+R E +R  A+G+  +
Sbjct: 1286 ELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGEREL 1345

Query: 1115 KEVLKVEKDAATE---------REVSDLTRQYEDEAAKARA----------SQREKTELL 1155
             +  K    A  E         R  +      E++   AR+          S+RE+ + L
Sbjct: 1346 LQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQAL 1405

Query: 1156 RKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLR--LELVEQERKYRGAEEQLRSYQ 1213
            ++   L+    K + QE +  + +   + E EV  LR  ++ +E++R+ + A  +L S  
Sbjct: 1406 QEQGELKVAQGKAL-QENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464

Query: 1214 SELEALRRRGPQVEVK-------EVTKEVIKY--KTDPEMEKELQRLREEI--VDKTRLI 1262
                 L++R  +V+++       E  + V+++      E E++L   RE+I  ++K R  
Sbjct: 1465 -----LKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRET 1519

Query: 1263 ERCDLE--IYQLKKEIQALKDTKPQVQTKE---VVQEILQFQEDPQTKEEVASLRAKLSE 1317
            +R  LE  + +L+K+ Q ++  + QVQ  +   V  E L          E+     K+  
Sbjct: 1520 QRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL--------ELEENHHKMEC 1571

Query: 1318 EQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDV 1377
            +QK   +LE +R +Q   +     +L    + +  Q    ++    L + ++  A  +  
Sbjct: 1572 QQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHD----LESHSTVLARELQE 1627

Query: 1378 ELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEA 1437
              +++   R ++  LQR++  L + LE  ++E   ++E  + ++  + R   + +E+ E 
Sbjct: 1628 RDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQ 1687

Query: 1438 -------REKVTHTQKVVLQQDPQQAR----------EHALLRLQ------------LEE 1468
                   R +   TQ+ ++Q+  ++ +          EH  L L+            + E
Sbjct: 1688 IKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHE 1747

Query: 1469 EQHRRQLLEGELETLRRKL---AALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEE 1525
             Q  +  LE +L+ L RK+   + L     +E VVL + +Q  +   E + Q L+S L+E
Sbjct: 1748 LQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDE 1807

Query: 1526 ESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLR---EENHKLQLER----QNLQLE 1578
              R+  + D E+  L+    + +    +  ++ D L+   E+ H    ER    Q+ + +
Sbjct: 1808 AQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQ 1867

Query: 1579 TRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQK 1638
             RRL+ E+   A E R                R+ +LE  L DL+  S++++  +  LQ+
Sbjct: 1868 ARRLEEEL---AVEGR----------------RVQALEEVLGDLRAESREQEKALLALQQ 1908

Query: 1639 RLGSVAVKREQRENHLRRS 1657
            +    A + E     L+ S
Sbjct: 1909 QCAEQAQEHEVETRALQDS 1927



 Score =  157 bits (398), Expect = 7e-38
 Identities = 373/1764 (21%), Positives = 714/1764 (40%), Gaps = 267/1764 (15%)

Query: 29   ELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKV-LDSEKLLYVLEA 87
            EL+E     A Q    I  T+ +++  +  + + ++    +V   K+ LD+E+     E 
Sbjct: 767  ELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQER 826

Query: 88   DAAIAKHMKHPQGDMIA---------EDIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNW 138
            DAA  +  +  Q    A         +++ QL+E+    R  H+Q    A++ ++     
Sbjct: 827  DAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLE----- 881

Query: 139  AALVEEKLD---KLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELR 195
                 EK++   +L  Q   T++  +  Q EE      + ++    +  + +KE+ S L 
Sbjct: 882  ----REKMELEMRLKEQQ--TEMEAIQAQREEER---TQAESALCQMQLETEKERVSLLE 932

Query: 196  AKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQY 255
               Q     + A QQ     QD   +   E     Q+  G +Q    +   +     RQ+
Sbjct: 933  TLLQTQKELADASQQLERLRQDMKVQKLKE-----QETTGILQTQLQEAQRELKEAARQH 987

Query: 256  ENFINRNLEAKEERINKLHSEGDQL----------LAAEHPGRNSIEAHMEAVHADWKEY 305
             +    +L A +E  + L  +   L          L A+   +  +E  ++    + +EY
Sbjct: 988  RD----DLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEY 1043

Query: 306  LNL---LICEESHL--KYMEDYHQF---HEDVKDAQELLRKVDSDLNQKYGPDFKDRYQI 357
              +   L  E++ L    ME   +     E     Q+ L  +  D+ +  G   +   Q+
Sbjct: 1044 NRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQM 1103

Query: 358  ELLLRELDDQE--------KVLDKYE-------DVVQGLQKRGQQVVPLKYR---RETPL 399
            ELL +E+ ++E        ++L++ E        +   L  +  +   L+ R    E+ L
Sbjct: 1104 ELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQL 1163

Query: 400  KPIPVEALCDFEGE-QGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPE 458
            + +  E     + + Q  ++  YS   Q          + +G    AP+V  + P  D  
Sbjct: 1164 EALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEP--DQN 1221

Query: 459  ALALADSLGSQYRSVRQKAAGSK-RTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASD 517
                    G    ++  +A  S    L Q  ++ KT+   D      R  +  L++  +D
Sbjct: 1222 GARSLFKRGPLLTALSAEAVASALHKLHQ--DLWKTQQTRDVL----RDQVQKLEERLTD 1275

Query: 518  LDRQEKAITGILRPPLEQGRAVQDSAERAKDLKN-ITNELLRI-EPEKTRSTAEGEAFIQ 575
             + ++  +   L+    Q    Q+   + +  +N + +EL+ + E   +  +    A +Q
Sbjct: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQ 1335

Query: 576  ALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHL 635
             +   G   LL+   E+   + EHL   +  A+ +   A  LE+ L+ +   L      +
Sbjct: 1336 RMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEV 1395

Query: 636  NQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCP 695
              +    E ++ L  +G+   A    LQ   +LL    Q L   ++   TL  + QE   
Sbjct: 1396 ESER---ERAQALQEQGELKVAQGKALQENLALL---TQTLAEREEEVETLRGQIQELEK 1449

Query: 696  DLERQEAEVHKLGQRFNNLRQQVE---RRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSY 752
              E Q+A +  L        Q+V+    + Q L+  ++  EH         Q L      
Sbjct: 1450 QREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTV---- 1505

Query: 753  EPQETDSLSQMETKLKNQKNLLD----EIASREQEVQKICANSQQYQQAVKDYELEAEKL 808
               + + + ++E   + Q+N+L+    E+  ++Q ++      Q  ++ +   E  A +L
Sbjct: 1506 ---QREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALEL 1562

Query: 809  RS-----------LLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRL 857
                         + +LE  R +   +R  L      ++E    L A+ ++++ +     
Sbjct: 1563 EENHHKMECQQKLIKELEGQRET---QRVALTHLTLDLEERSQELQAQSSQIHDLESH-- 1617

Query: 858  QNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQ 917
             +   A  L  +  EV+   E          +EE  + ++ L ++ ERR Q   E+   +
Sbjct: 1618 -STVLARELQERDQEVKSQREQ---------IEELQRQKEHLTQDLERRDQ---ELMLQK 1664

Query: 918  EEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQ-----QLQRTLAEE-QHKNQLLQEEL 971
            E I  L +Q  +++ + +E L+++   + E   +     QL +  AEE +  ++  +  L
Sbjct: 1665 ERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSL 1724

Query: 972  EALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGA----- 1026
            E ++L LR  E+E     Q+  + E+  ++          QL ++L+ L R+ G      
Sbjct: 1725 EHMKLILRDKEKEVEC--QQEHIHELQELKD---------QLEQQLQGLHRKVGETSLLL 1773

Query: 1027 --REAEVLLLQQRVAALAEE----KSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQ 1080
              RE E+++LQQ++    E+    +   Q ++ E +    Q D +LEA  Q+ Q+   ++
Sbjct: 1774 SQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQE 1833

Query: 1081 DQLREKQEEELSFLQDKLKRLEKERAMAEGKIT--VKEVLKVEKDAATE-REVSDLTRQY 1137
            ++++EK +     LQ  L++         G++    ++  ++E++ A E R V  L    
Sbjct: 1834 ERVKEKADA----LQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQAL---- 1885

Query: 1138 EDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVE 1197
            E+     RA  RE+ + L    AL+++ A+   + +V      D   +++     L+  +
Sbjct: 1886 EEVLGDLRAESREQEKALL---ALQQQCAEQAQEHEVETRALQDSWLQAQAV---LKERD 1939

Query: 1198 QERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEK-ELQR-LREEI 1255
            QE +   AE Q   +Q E    R    Q E        ++ K    +E+ EL R L    
Sbjct: 1940 QELEALRAESQSSRHQEEAARARAEALQ-EALGKAHAALQGKEQHLLEQAELSRSLEAST 1998

Query: 1256 VDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKL 1315
                  ++ C     QL++ ++        +Q  E+  + L++QED Q  ++  + R   
Sbjct: 1999 ATLQASLDACQAHSRQLEEALR--------IQEGEIQDQDLRYQEDVQQLQQALAQR--- 2047

Query: 1316 SEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESI 1375
             EE + Q   ERE+  ++    R +E + + K+ + Q+      EE  +R    +  E +
Sbjct: 2048 DEELRHQQ--EREQLLEKSLAQRVQENMIQEKQNLGQER-----EEEEIRGLHQSVRE-L 2099

Query: 1376 DVELRQIDKLRAELRRLQRRRT--ELERQLEELERERQARR------EAEREVQRLQQRL 1427
             + L Q ++   ELR  Q+R     L    +    E Q+ +        +RE++RLQ  L
Sbjct: 2100 QLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAAL 2159

Query: 1428 AALEQEEAEAREKVTHTQKVVLQQDPQQAREHAL------LRLQLEEEQHRRQLLEGELE 1481
               E  E E REK    Q + L     +A   +L      L+  + E    +Q L+ ELE
Sbjct: 2160 RQTEAREIEWREKA---QDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELE 2216

Query: 1482 TLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKS--------SLEEESRSKR-- 1531
              RR   ALEK  +      S +    +G+   ++  +           +E++S  +R  
Sbjct: 2217 LTRR---ALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLE 2273

Query: 1532 ELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAAT 1591
             L   V+RLE   S L+ HN +    L+         Q+ER     E R+L+ E   AA 
Sbjct: 2274 HLQQAVARLEIDRSRLQRHNVQLRSTLE---------QVER-----ERRKLKREAMRAAQ 2319

Query: 1592 ETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLE-IDELQKRL----GSVAVK 1646
                  +   A S T  D              R  K+ D + + ELQK +      + ++
Sbjct: 2320 AGSLEISKATASSPTQQDG-------------RGQKNSDAKCVAELQKEVVLLQAQLTLE 2366

Query: 1647 REQRENHLRRSIVVIHPDTGRELS 1670
            R+Q+++++ RS       T REL+
Sbjct: 2367 RKQKQDYITRS-----AQTSRELA 2385



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 202/1040 (19%), Positives = 424/1040 (40%), Gaps = 155/1040 (14%)

Query: 674  QNLQAAKQCSSTLASRFQEH-------CPDLERQ-EAEVHKLGQRFNNLRQQVERRAQSL 725
            +N Q A+Q  +TL  + Q         C +LE++ EA    + QR+ N+ +         
Sbjct: 43   KNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWENVEEP-------- 94

Query: 726  QSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEI-ASREQEV 784
                           ++ + LV +   E Q  +SL+++ T+L+      D +  +  ++V
Sbjct: 95   ---------------NLDELLVRLEE-EQQRCESLAEVNTQLRLHMEKADVVNKALREDV 138

Query: 785  QKICAN----SQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRA---RLQSPATKVKE 837
            +K+  +      +  +    +++E E  +  L  E+GR   + +     R      K   
Sbjct: 139  EKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSAT 198

Query: 838  EEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRK 897
            +   +  K   V          L   +    ++P      +  +  +    + +  ++ K
Sbjct: 199  DRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEK 258

Query: 898  ELDEETERRRQLEN-------EVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPV--LEE 948
            E  E ++   QL++       E++    E+  L  Q  +++   ++++K + + V  LE 
Sbjct: 259  EAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILET 318

Query: 949  SFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVV----KEVLRIEP-- 1002
            +  +L   +  E   ++  QEE  +LQ  ++ + Q   + G         +  L ++   
Sbjct: 319  NHTEL---MEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSI 375

Query: 1003 ----DRAQADEVLQL--------REELEALRRQKGAREAEVLLLQQRVAALAEE----KS 1046
                D   AD+ L L        R+ ++ LR+Q    +  V LLQQ+     EE    + 
Sbjct: 376  FSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQ 435

Query: 1047 RAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERA 1106
            R Q+   E++ +  Q    L+ E   L ++ +   + RE+  ++L  L+ +  RL +   
Sbjct: 436  RLQKLTGERDTLAGQT-VDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRR--- 491

Query: 1107 MAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENA 1166
                   V   L+++ D+A          Q E++  +   + RE+  L   +  LE + +
Sbjct: 492  -------VNVELQLQGDSAQG--------QKEEQQEELHLAVRERERLQEMLMGLEAKQS 536

Query: 1167 KVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQV 1226
                 E + E++      ES  ++L  EL+ QE             Q+E+ A   R  Q 
Sbjct: 537  -----ESLSELITLREALES--SHLEGELLRQE-------------QTEVTAALARAEQ- 575

Query: 1227 EVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQV 1286
             + E++      KT      E+  LR   V  + L E   L+   L +++  L++    V
Sbjct: 576  SIAELSSSENTLKT------EVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSV 629

Query: 1287 QTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRV 1346
             ++    E           +   +L+  L+E +K++  L  +    E Q+ + EE  + +
Sbjct: 630  CSRMEAAE-----------QARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAEL 678

Query: 1347 KERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEEL 1406
            +  +   +    EE+  ++ + S      +    Q+++L  E +R +       ++ E L
Sbjct: 679  QADLRDIQ----EEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEAL 734

Query: 1407 ERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQL 1466
             RE+ A     + V+R +Q LA   Q  + A+E +  +     QQ+         L +Q+
Sbjct: 735  VREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQI 794

Query: 1467 EEEQHRRQLLEGELETLRRKL-AALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEE 1525
            +     +++++GE+  L+ +L     +AE +      +  Q E        Q  K++LE+
Sbjct: 795  QTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAE--------QEGKTALEQ 846

Query: 1526 ESRSKRELDVEVSRLEARL-SELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQS 1584
            +   K   + EV++L  +   E  +H  + +K L+ L  E  +L++  +  Q E   +Q+
Sbjct: 847  Q---KAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA 903

Query: 1585 EINMAATETRDLRNMTVADSGTNHDSRLWSL---ERELDD----LKRLSKDKDLEIDELQ 1637
            +     T+          ++     S L +L   ++EL D    L+RL +D  ++  + Q
Sbjct: 904  QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQ 963

Query: 1638 KRLGSVAVKREQRENHLRRS 1657
            +  G +  + ++ +  L+ +
Sbjct: 964  ETTGILQTQLQEAQRELKEA 983



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 177/956 (18%), Positives = 348/956 (36%), Gaps = 169/956 (17%)

Query: 17   VQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQE-GRQPEH-------- 67
            ++ RS   +  S  I  L+ ++  + + + + + +++S   +++E  RQ EH        
Sbjct: 1597 LEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERR 1656

Query: 68   -RDVTLQK----VLDSEKLLY--VLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGK 120
             +++ LQK    VL+ ++     +LE D    K     +G  +    + ++ER    +G 
Sbjct: 1657 DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716

Query: 121  HKQ----------IYRLAVKEVDPQVNWAALVEEKLDKLNNQ------SFGTDLPLVDHQ 164
             K           I R   KEV+ Q      ++E  D+L  Q        G    L+  +
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776

Query: 165  VEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTN 224
             +E  +   +++      A++  + +   L+++  +   A   R Q L +LQ   Q+   
Sbjct: 1777 EQEIVVLQQQLQE-----AREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQG 1831

Query: 225  ELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAE 284
            +   + ++A   +Q      ++    R  +        L+  +E+  +L  E    LA E
Sbjct: 1832 QEERVKEKADA-LQGALEQAHMTLKERHGE--------LQDHKEQARRLEEE----LAVE 1878

Query: 285  HPGRNSIEAHMEAVHADWKEYLNLLI-----CEESHLKYMEDYHQFHEDVKDAQELLRKV 339
                 ++E  +  + A+ +E    L+     C E   ++  +     +    AQ +L++ 
Sbjct: 1879 GRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKER 1938

Query: 340  DSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPL 399
            D +L          R+Q E      +  ++ L K    +QG   + Q ++          
Sbjct: 1939 DQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQG---KEQHLL---------- 1985

Query: 400  KPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEA 459
                         EQ  +SR    +L+ +       +D+                    +
Sbjct: 1986 -------------EQAELSR----SLEASTATLQASLDAC----------------QAHS 2012

Query: 460  LALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLL-AGLDKVASDL 518
              L ++L  Q   ++ +    +  +QQ  + L   +       +  QLL   L +   + 
Sbjct: 2013 RQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQEN 2072

Query: 519  DRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALP 578
              QEK   G  R   E     Q   E    L     E+L +   + R+       ++ALP
Sbjct: 2073 MIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNN------LEALP 2126

Query: 579  GSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQD 638
             S  T    + +E+ + K + L   L    E++  A R  ++ +  W             
Sbjct: 2127 HSHKT----SPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWR------------ 2170

Query: 639  DTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLE 698
                        K Q+LA    + +A  S L EV   LQA+                 LE
Sbjct: 2171 -----------EKAQDLALSLAQTKASVSSLQEVAMFLQASV----------------LE 2203

Query: 699  RQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETD 758
            R ++E  +L       R+ +E+       A +  E   RG   V   L  +   E + + 
Sbjct: 2204 R-DSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQ--LGEVSGVEAEPSP 2260

Query: 759  SLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKL-RSLLDLENG 817
               + ++  +  ++L   +A  E +  ++  ++ Q +  ++  E E  KL R  +     
Sbjct: 2261 DGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQA 2320

Query: 818  RSSHVSKRARLQSPATK----VKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEV 873
             S  +SK A   SP  +     K  +A   A+  +   +       L+  L L R+Q + 
Sbjct: 2321 GSLEISK-ATASSPTQQDGRGQKNSDAKCVAELQKEVVL-------LQAQLTLERKQKQD 2372

Query: 874  EVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEI-WTLRNQGP 928
             +T  + Q +R  +G+  +         +      LE E +   E +  +L + GP
Sbjct: 2373 YIT-RSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPGP 2427


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  169 bits (428), Expect = 2e-41
 Identities = 386/1813 (21%), Positives = 727/1813 (40%), Gaps = 286/1813 (15%)

Query: 22   ISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKL 81
            +  K   E  +Q ++  D+V +   + E + +  + R +E +  E      +++ + E+ 
Sbjct: 218  LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQ 277

Query: 82   LYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNWAAL 141
            L  LE      +  +  Q        +Q   R   LR K ++  R   +E   Q      
Sbjct: 278  LRKLERQELRRERQEEEQQ-------QQRLRREQQLRRKQEEERREQQEERREQQERREQ 330

Query: 142  VEEKLDKL--NNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQ 199
             EE+ ++     Q    +  L   Q EE              L ++ ++E+  +   + Q
Sbjct: 331  QEERREQQLRREQEERREQQLRREQEEERR---------EQQLRREQEEERREQQLRREQ 381

Query: 200  KLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFI 259
            +L    Q R++     +  ++R        +QQ +   Q     +       RR+ E   
Sbjct: 382  QLRREQQLRREQQLRREQQLRR--------EQQLRREQQLRREQQLRREQQLRREQEEER 433

Query: 260  NRNLEAKEERINKLHSEGDQ----LLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESH 315
            +     +E R  +L  E ++    L   E   R+  E   + +  D +E        E  
Sbjct: 434  HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERR-----ERW 488

Query: 316  LKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDKYE 375
            LK  E+  +  ++ ++ Q+L R+ +    Q+     K + + E L + L  ++++  + E
Sbjct: 489  LKLEEEERREQQERRE-QQLRREQEERREQR----LKRQEEEERLQQRLRSEQQLRREQE 543

Query: 376  DVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWEL 435
            +  + L KR ++    + RRE  LK    E          L+ R      Q+   E  E 
Sbjct: 544  ERREQLLKREEEKRLEQERREQRLKREQEER------RDQLLKREEERRQQRLKREQEER 597

Query: 436  MDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTEN 495
            ++              +   + E L        Q     Q+    +   ++R ++LK+E 
Sbjct: 598  LEQR------------LKREEVERL-------EQEERREQRLKREEPEEERRQQLLKSEE 638

Query: 496  PGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNE 555
              +    Q R+      +     + +E+ +   L+   E+ R  Q+ AE  ++      E
Sbjct: 639  QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQ---ARE 695

Query: 556  LLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVAN 615
             ++    K +   E EA  +           +++V    RK E   +     QE+ +   
Sbjct: 696  RIKSRIPKWQWQLESEADAR-----------QSKVYSRPRKQEGQRR----RQEQEEKRR 740

Query: 616  RLEKSLQQSWELLA---THENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEV 672
            R E  LQ   E  A     E    +D T    +     +G++       L A+  L  + 
Sbjct: 741  RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ------RLSARPPLREQR 794

Query: 673  EQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAY 732
            E+ L+A ++       R Q   P+ E +E             R+Q   R + LQ  +   
Sbjct: 795  ERQLRAEER-----QQREQRFLPEEEEKEQR-----------RRQRREREKELQFLEEEE 838

Query: 733  EHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQ 792
            +   R     LQ          +E D L + + + ++Q+   D+    + E ++      
Sbjct: 839  QLQRRERAQQLQ----------EEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888

Query: 793  QYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAI 852
             Y +     +L  E+ + L + E        ++ R Q    + +EEE             
Sbjct: 889  LYAKPALQEQLRKEQ-QLLQEEEEELQREEREKRRRQEQERQYREEE------------- 934

Query: 853  NRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENE 912
               +LQ  E    LLR++ E     E  ++ R D  +++  K  + L EE E+RR+ E E
Sbjct: 935  ---QLQQEEE--QLLREEREKRRRQERERQYRKDKKLQQ--KEEQLLGEEPEKRRRQERE 987

Query: 913  VKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPV-----LEESFQQLQRTLAEEQHKNQLL 967
             K  +EE      Q  +E ++R+E  K+           ++  QQ +  L  E+ + + L
Sbjct: 988  KKYREEE----ELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRL 1043

Query: 968  QE------ELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALR 1021
            QE      E E LQ +   L  E R+  +   ++   R E +  Q +E L LREE E  R
Sbjct: 1044 QERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL-LREEPEKRR 1102

Query: 1022 RQKGAREA--EVLLLQQRVAALAEEKS-----------RAQEKVTEKEVVKLQNDPQ--- 1065
            RQ+  R+   E  L Q+    L EE+            R +E+V ++E   L+ +P+   
Sbjct: 1103 RQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR 1162

Query: 1066 ---LEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEV----- 1117
               LE +Y++ +E  Q ++QL  +++E+    +++  R E+E    + K   ++      
Sbjct: 1163 RQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSD 1222

Query: 1118 LKVEKDAATEREVSDLT-----------RQYEDEAAKARASQREKTELL----------- 1155
            LK + +   E  V D             RQ ED   + R SQ++   LL           
Sbjct: 1223 LKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQE 1282

Query: 1156 RKIWALEEEN---AKVVVQEKVREIVRPDPKAESEVANLRLELVEQ------ERKYRGAE 1206
            R+ W   + +    + + +E+ +E  R D K++ E   LR E  E+      +RK+R  E
Sbjct: 1283 RRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEE 1342

Query: 1207 EQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCD 1266
            + L+  + E + LRR+    + +E  +E+   +   +  +E QRLR +  ++  L E   
Sbjct: 1343 QLLQ--EREEQPLRRQERDRKFRE--EELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQ 1398

Query: 1267 LEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSE----EQKKQ 1322
            L   + +++++  +D K     +E  Q++ + + D + +EE   +R +  E    E+++Q
Sbjct: 1399 LRCQEREQQLRQDRDRK----FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQ 1454

Query: 1323 VDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQI 1382
            +  ER R  +EE+   +E E  ++  +   ++ +  E++   +     F E    ELR  
Sbjct: 1455 LRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ---ELRSQ 1511

Query: 1383 DKLRA------ELRRLQRRRTEL--ERQLEELERERQARREAEREVQRLQQRLAALEQEE 1434
            +  R       +L R QR+R  L  E+QL   ER +Q R++ +R+ +  +Q     E+++
Sbjct: 1512 EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQ 1571

Query: 1435 AEAREKVT----HTQKVVLQQDPQQARE-HALLRLQLEEEQHR----RQLLEGELETLRR 1485
               +E+        QKV  Q+  ++  E    LR Q  ++Q R    R+  E E     R
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER 1631

Query: 1486 KLAALEKAEVKEKVVLSESVQVEKGDTEQEI-----------QRLKSSLEEESRSKRELD 1534
            +   L + E +++  L E  Q+ + + EQ++           ++L    EE+   ++E D
Sbjct: 1632 EEQQLHRQE-RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERD 1690

Query: 1535 VEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETR 1594
             +    E +L   E       +E  FL+EE    QL RQ L+ + R  + E     TE  
Sbjct: 1691 RKFREEEQQLRRQE-------RERKFLQEEQ---QLRRQELERKFR--EEEQLRQETEQE 1738

Query: 1595 DLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHL 1654
             LR           +      ERE   L+R  +D+    +E         +++E+ E  L
Sbjct: 1739 QLRRQERYRKILEEEQ--LRPEREEQQLRRQERDRKFREEE--------QLRQEREEQQL 1788

Query: 1655 RRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIHDR- 1713
            R        ++ R+   EE  R    +  +  + R  +  WEE  ++    E  +  +R 
Sbjct: 1789 RSQ------ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERD 1842

Query: 1714 ---KSGKKFSIEE 1723
               ++ ++F+ +E
Sbjct: 1843 RQYRAEEQFATQE 1855



 Score =  163 bits (413), Expect = 1e-39
 Identities = 319/1588 (20%), Positives = 657/1588 (41%), Gaps = 214/1588 (13%)

Query: 22   ISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGR-QPEHRDVTLQKVLDSEK 80
            +  +E  E ++Q  ++  Q+ +   + E + +  L R +E R + E R+  L++  +  +
Sbjct: 519  LKRQEEEERLQQRLRSEQQLRR---EQEERREQLLKREEEKRLEQERREQRLKREQEERR 575

Query: 81   LLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNWAA 140
               +   +    + +K  Q + + + ++  +E V  L  + ++  RL  +E + +     
Sbjct: 576  DQLLKREEERRQQRLKREQEERLEQRLK--REEVERLEQEERREQRLKREEPEEERRQQL 633

Query: 141  LVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQK 200
            L  E+ ++   Q    +      + E+      E + +   L ++ ++E+  +  A+ ++
Sbjct: 634  LKSEEQEERRQQQLRREQ---QERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690

Query: 201  LLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFIN 260
                 QAR++  S +  +        + L+ +A  R    +S        RRRQ +    
Sbjct: 691  ----EQARERIKSRIPKWQ-------WQLESEADARQSKVYSRPRKQEGQRRRQEQE--- 736

Query: 261  RNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYME 320
               E +  R ++L  + +                 E  H   +E       EE    +  
Sbjct: 737  ---EKRRRRESELQWQEE-----------------ERAHRQQQE-------EEQRRDFTW 769

Query: 321  DYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQE-KVLDKYEDVVQ 379
             +    +  +  Q L  +          P  +++ + +L   E   +E + L + E+  Q
Sbjct: 770  QWQAEEKSERGRQRLSAR----------PPLREQRERQLRAEERQQREQRFLPEEEEKEQ 819

Query: 380  GLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLIS---RGYSYTLQKNNGESWELM 436
              ++R ++   L++  E         A    E E GL     R  S   +++    W+L 
Sbjct: 820  RRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLE 879

Query: 437  DSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENP 496
            +    +                 L    +L  Q R  +Q        LQ+  E L+ E  
Sbjct: 880  EERKRRR--------------HTLYAKPALQEQLRKEQQ-------LLQEEEEELQREE- 917

Query: 497  GDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKD--LKNITN 554
                + + RQ      +    L ++E+ +   LR   E+ R  +   +  KD  L+    
Sbjct: 918  ---REKRRRQEQERQYREEEQLQQEEEQL---LREEREKRRRQERERQYRKDKKLQQKEE 971

Query: 555  ELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVA 614
            +LL  EPEK R                     R   E   R+ E L Q     +E+  + 
Sbjct: 972  QLLGEEPEKRR---------------------RQEREKKYREEEELQQ-----EEEQLLR 1005

Query: 615  NRLEKSLQQSWELLATHENHLNQDDTV----PESSRVLDSKGQELAAMACELQAQKSLLG 670
               EK  +Q WE     ++ L Q++          R L  + ++        Q ++ LLG
Sbjct: 1006 EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG 1065

Query: 671  EVEQNLQAAK-QCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQ--- 726
            E  +  +  + +         Q+    L R+E E  +  +R    R++ E + +  Q   
Sbjct: 1066 EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLR 1125

Query: 727  -----SAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIAS-- 779
                   +   E  +R  + V Q    +   EP++     ++E + + ++ L  E     
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR-QELERQYREEEELQQEEEQLL 1184

Query: 780  REQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSS-----HVSKRARLQSPATK 834
            RE++ ++     +QY++   + EL+ +K +     E+ RS         K   ++     
Sbjct: 1185 REEQEKRRQERERQYRE---EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY 1241

Query: 835  VKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWK 894
             K  E     +  +    +RQ  Q+L+   +LL +Q E +   E  +  + D    E  +
Sbjct: 1242 CKGRENEQFRQLEDSQLRDRQSQQDLQ---HLLGEQQERDREQERRRWQQRDRHFPEEEQ 1298

Query: 895  IRKELDEETERR-RQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQL 953
            + +E  +E +RR R+ + E +  +EE    R +   +   R+E      + +L+E  +Q 
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREE------EQLLQEREEQ- 1351

Query: 954  QRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQL 1013
               L  ++   +  +EEL   +   + LE+E R   QE   K +   +  R Q  E  QL
Sbjct: 1352 --PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQ-QL 1408

Query: 1014 REELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQL 1073
            R++    R +K   E + L  Q+R     EE+ + + +  E++         LE E Q  
Sbjct: 1409 RQD----RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF--------LEEEQQLR 1456

Query: 1074 QEDHQR---QDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREV 1130
            QE H++   ++QL +++EE+      +L R E++R   E +  ++   +  K    E   
Sbjct: 1457 QERHRKFREEEQLLQEREEQ------QLHRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510

Query: 1131 SDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVAN 1190
             +  R++ +E  +    QR++  L  +     +E  +   Q++ R+  R + +   E   
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKF-REEEQLRQEREE 1569

Query: 1191 LRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQR 1250
             +L   E++RK+R  E+++R  + E + +          E  +++ + +   ++ +E  R
Sbjct: 1570 QQLSRQERDRKFRLEEQKVRRQEQERKFM----------EDEQQLRRQEGQQQLRQERDR 1619

Query: 1251 LREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVAS 1310
               E  D+  L ER + ++++ +++ + L++ +PQ++ +E  Q+ L+   D + +EE   
Sbjct: 1620 KFRE--DEQLLQEREEQQLHRQERDRKFLEE-EPQLRRQEREQQ-LRHDRDRKFREEEQL 1675

Query: 1311 LRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASA 1370
            L+    E+Q ++ + +R+   +E+Q+ R+E E   ++E   +Q++ R E E   R E   
Sbjct: 1676 LQEG-EEQQLRRQERDRKFREEEQQLRRQERERKFLQE---EQQLRRQELERKFREEEQL 1731

Query: 1371 FAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAAL 1430
              E+   +LR+ ++ R  L   Q R    E+QL   ER+R+ R E +   +R +Q+L + 
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ 1791

Query: 1431 E-----QEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRR 1485
            E     +EE + R++    Q    Q+D +   E    +LQLEE++ R +           
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEE--QLQLEEQEQRLRQERDRQYRAEE 1849

Query: 1486 KLAALEKAEVKEKVVLSESVQVEKGDTEQEI--QRLKSSLEEESRSKR--ELDVEVSRLE 1541
            + A  EK+  +E+ +  E  Q  + + E+++  + ++   +EE R ++  E+  +  +  
Sbjct: 1850 QFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGH 1909

Query: 1542 ARLSELEFHN-----SKSSKELDFLREE 1564
             RL E   H       +SS   ++++E+
Sbjct: 1910 GRLLEPGTHQFASVPVRSSPLYEYIQEQ 1937



 Score =  162 bits (411), Expect = 2e-39
 Identities = 371/1752 (21%), Positives = 709/1752 (40%), Gaps = 252/1752 (14%)

Query: 20   RSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGR---------QPEHRDV 70
            + +  K+  E  EQ ++  +Q E+     E + +  L R QE R         + E R+ 
Sbjct: 304  QQLRRKQEEERREQQEERREQQERR-EQQEERREQQLRREQEERREQQLRREQEEERREQ 362

Query: 71   TLQKVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVK 130
             L++  + E+    L  +  + +  +  +   +  +  Q   R   LR + +Q+ R    
Sbjct: 363  QLRREQEEERREQQLRREQQLRREQQLRREQQLRRE--QQLRREQQLR-REQQLRREQQL 419

Query: 131  EVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQ 190
              + Q+      EE+  +  ++    +  L   Q E  +            L ++ + E+
Sbjct: 420  RREQQLRREQ--EEERHEQKHEQERREQRLKREQEERRD-----------WLKREEETER 466

Query: 191  NSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPS 250
            + + R K Q      + R++    L++  +R   E     +Q   R Q +  ++ L    
Sbjct: 467  HEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR---EQQLRREQEERREQRL---- 519

Query: 251  RRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLI 310
            +R++ E  + + L ++++   +     +QLL  E   R   E   + +  + +E  + L 
Sbjct: 520  KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL- 578

Query: 311  CEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIE-----LLLRELD 365
                 LK  E+  Q        Q L R+ +  L Q+   +  +R + E      L RE  
Sbjct: 579  -----LKREEERRQ--------QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEP 625

Query: 366  DQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTL 425
            ++E+     +   Q  +++ Q     + RRE  LK    E       EQ L         
Sbjct: 626  EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL----EQRLKREHEEERR 681

Query: 426  QKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQ 485
            ++   E  E  + A  ++ +      IP    +  + AD+  S+  S  +K  G +R  +
Sbjct: 682  EQELAE--EEQEQARERIKSR-----IPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE 734

Query: 486  QRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQ----EKAITG----ILRPPLEQGR 537
            Q  +  + E+     + +        ++   D   Q    EK+  G      RPPL + R
Sbjct: 735  QEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQR 794

Query: 538  AVQDSAE------------------RAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPG 579
              Q  AE                  R +  +    EL  +E E+     E    +Q    
Sbjct: 795  ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEED 854

Query: 580  SGTTPLLRTRVEDTNRKYEHLLQLLDLAQEK---VDVANRLEKSLQQSWELLATHENHLN 636
                   R R ++  R  +   QL +  + +   +     L++ L++  +LL   E  L 
Sbjct: 855  GLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQ 914

Query: 637  QDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPD 696
            +++   E  R  + + Q       + + ++ L  E E+  +  ++       + Q+    
Sbjct: 915  REER--EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQ 972

Query: 697  LERQEAEVHKLGQRFNNLRQQVERRAQSLQ--------SAKAAYEHFHRGHDHVLQFLVS 748
            L  +E E  +  +R    R++ E + +  Q          +  +E  +R  D + Q    
Sbjct: 973  LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ 1032

Query: 749  IPSYEPQETDSLSQMETKLKNQKNLLDE---IASREQEVQKICANSQQYQQAVKDYELEA 805
            +   E +E   L + E + + ++ L  E   +   E+E ++     +QY+   K+ EL+ 
Sbjct: 1033 LLR-EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR---KEEELQQ 1088

Query: 806  EKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALN 865
            E+ + L +    R     +R R      ++++EE  L  +  E     ++R Q LE    
Sbjct: 1089 EEEQLLREEPEKRRRQ--ERERQCREEEELQQEEEQLLREERE-----KRRRQELE---R 1138

Query: 866  LLRQQPEVEVTHETLQRNRPDSG----VEEAWKIRKELD--------EETERRRQLENEV 913
              R++ EV+   E L R  P+      +E  ++  +EL         EE E+RRQ     
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198

Query: 914  KSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLE---------------ESFQQLQRTLA 958
               +EE+   + +       ++  LK   +P  E               E F+QL+ +  
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQL 1258

Query: 959  EEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELE 1018
             ++   Q LQ  L          EQ+ RD  QE   +   +        +E L+  E+ E
Sbjct: 1259 RDRQSQQDLQHLLG---------EQQERDREQE---RRRWQQRDRHFPEEEQLEREEQKE 1306

Query: 1019 ALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQL--EAEYQQLQED 1076
            A RR + ++E + LL ++R     EEK R QE  T++   K + + QL  E E Q L+  
Sbjct: 1307 AKRRDRKSQEEKQLLREER-----EEKRRRQE--TDR---KFREEEQLLQEREEQPLRRQ 1356

Query: 1077 HQ----RQDQLREKQEEELSFLQD--KLKRLEKERAMAEGKITVK-----EVLKVEKDAA 1125
             +    R+++LR  QE+   FL++  +L+R E+ER   + +  ++     + L+ ++D  
Sbjct: 1357 ERDRKFREEELRH-QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415

Query: 1126 TEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAE 1185
               E   L+RQ  D   +    Q  + E  RK   LEEE    + QE+ R+  R + +  
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKF--LEEEQQ--LRQERHRKF-REEEQLL 1470

Query: 1186 SEVANLRLELVEQERKYRGAEEQLRSYQSEL----EALRRRGPQVEVKEVTKEVIKYKTD 1241
             E    +L   E++RK+   E+QLR  + +     + LR + P+ +  E  +++ + +  
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530

Query: 1242 PEMEKELQRLREEIVDKTRLIERC----DLEIYQLKKEIQALKDTKPQVQTKEVVQEILQ 1297
             +  +E Q+LR +   + R  +R     + E  + ++E Q L   +   + +   Q++ +
Sbjct: 1531 RKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRR 1590

Query: 1298 FQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVR 1357
             +++ +  E+   LR +  ++Q +Q   ER+R  +E++   +E E  ++  +   ++ + 
Sbjct: 1591 QEQERKFMEDEQQLRRQEGQQQLRQ---ERDRKFREDEQLLQEREEQQLHRQERDRKFL- 1646

Query: 1358 YEEEPGLRAEASAFAESIDVELR--QIDKLRAELRRLQRRRTELERQLEELERERQARRE 1415
             EEEP LR +        + +LR  +  K R E + LQ      E+QL   ER+R+ R E
Sbjct: 1647 -EEEPQLRRQER------EQQLRHDRDRKFREEEQLLQEGE---EQQLRRQERDRKFREE 1696

Query: 1416 AEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQL 1475
             E++++R Q+R     QEE + R           Q+  ++ RE   LR + E+EQ RRQ 
Sbjct: 1697 -EQQLRR-QERERKFLQEEQQLRR----------QELERKFREEEQLRQETEQEQLRRQ- 1743

Query: 1476 LEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDV 1535
                     R    LE+ +++ +    +  + E+    +E ++L+   EE+    +E D 
Sbjct: 1744 --------ERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDR 1795

Query: 1536 EVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRD 1595
            +    E    E E    +  +     R E  +LQLE Q  +L   R          + R 
Sbjct: 1796 KFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQER--------DRQYRA 1847

Query: 1596 LRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLR 1655
                   +     +  LW  E +    KR          E +++L    ++R+Q+E    
Sbjct: 1848 EEQFATQEKSRREEQELWQEEEQ----KRR--------QERERKLREEHIRRQQKEEQRH 1895

Query: 1656 RSIVVIHPDTGR 1667
            R +  I    G+
Sbjct: 1896 RQVGEIKSQEGK 1907



 Score =  162 bits (410), Expect = 3e-39
 Identities = 285/1208 (23%), Positives = 507/1208 (41%), Gaps = 175/1208 (14%)

Query: 515  ASDLDRQEKAITGILRPPLEQGRAVQDSAE---RAKDLKNITNELLRIE-PEKTRSTAEG 570
            A+ LD +++A        L+  R  +D      R + L+    +  R +  E+ R  AEG
Sbjct: 92   ATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEG 151

Query: 571  EAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLAT 630
            E   +           R    D  R+ E L +     QE+ +   R E+   QS +    
Sbjct: 152  EEQSEKQE--------RLEQRDRQRRDEELWRQRQEWQEREE--RRAEEEQLQSCK---G 198

Query: 631  HENHLNQDDTVPESSRVLD--SKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLAS 688
            HE     D+       +L+   KG+E        +  +    E E+  +  +        
Sbjct: 199  HETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258

Query: 689  RFQEHCP----DLERQEAEVHKLG-QRFNNLRQQVERRAQSL---QSAKAAYEHFHRGHD 740
            + QE  P    +L+ +E ++ KL  Q     RQ+ E++ Q L   Q  +   E   R   
Sbjct: 259  KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318

Query: 741  HVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKD 800
                        E +E     + + + + Q+   ++   REQ++++     ++ QQ  ++
Sbjct: 319  E-----------ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE 367

Query: 801  YELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNL 860
             E E  + +   + +  R   + +  +L+      +E++     +      + R++    
Sbjct: 368  QEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 427

Query: 861  EFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETE---RRRQLENEVKSTQ 917
            E       Q+ E E   + L+R + +      W  R+E  E  E   R++QL+ + +  +
Sbjct: 428  EQEEERHEQKHEQERREQRLKREQEE---RRDWLKREEETERHEQERRKQQLKRDQEEER 484

Query: 918  EEIWT-LRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQL 976
             E W  L  +  +E   R+E              QQL+R   E + +    QEE E LQ 
Sbjct: 485  RERWLKLEEEERREQQERRE--------------QQLRREQEERREQRLKRQEEEERLQQ 530

Query: 977  QLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQ 1036
            +LR+ +Q  R+  QE   +++L+ E ++    E           R Q+  RE E    ++
Sbjct: 531  RLRSEQQLRRE--QEERREQLLKREEEKRLEQE----------RREQRLKREQE----ER 574

Query: 1037 RVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQL-REKQEEELSFLQ 1095
            R   L  E+ R Q+++  ++  +L+   + E E ++L+++ +R+ +L RE+ EEE    Q
Sbjct: 575  RDQLLKREEERRQQRLKREQEERLEQRLKRE-EVERLEQEERREQRLKREEPEEERR--Q 631

Query: 1096 DKLKRLEKE---RAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKT 1152
              LK  E+E   +     +   +   +++++   ER    L R++E+E  +   ++ E+ 
Sbjct: 632  QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691

Query: 1153 ELLRKI--------WALEEE----NAKVVVQEKVREIVRPDPKAESEVANLRLEL--VEQ 1198
            +   +I        W LE E     +KV  + + +E  R   + E +      EL   E+
Sbjct: 692  QARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEE 751

Query: 1199 ERKYRGAEEQLR----SYQSELEALRRRGPQ-VEVKEVTKE--VIKYKTDPEMEKELQRL 1251
            ER +R  +E+ +    ++Q + E    RG Q +  +   +E    + + +   ++E + L
Sbjct: 752  ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFL 811

Query: 1252 REEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASL 1311
             EE   + R  +R + E     KE+Q L++ + Q+Q +E  Q+ LQ +ED   +++    
Sbjct: 812  PEEEEKEQRRRQRRERE-----KELQFLEE-EEQLQRRERAQQ-LQEEEDGLQEDQERRR 864

Query: 1312 RAKLSEEQKKQVDLERERASQ----------EEQIARKEEELSRVKERVVQQEV----VR 1357
              +   +QK +  LE ER  +          +EQ+ RKE++L + +E  +Q+E      R
Sbjct: 865  SQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL-RKEQQLLQEEEEELQREEREKRRR 923

Query: 1358 YEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEEL-------ERER 1410
             E+E   R E     E   +   + +K R + R  Q R+ +  +Q EE        +R R
Sbjct: 924  QEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRR 983

Query: 1411 QARREAEREVQRLQQRLAALEQEEAEAREKV----THTQKVVLQQDPQQ--AREHALLRL 1464
            Q R +  RE + LQQ    L +EE E R +      + +K  LQQ+ +Q    E    RL
Sbjct: 984  QEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRL 1043

Query: 1465 QLEEEQHR---------RQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQE 1515
            Q  E Q+R          QLL  E ET RR+   LE+   KE+ +  E  Q+ + + E  
Sbjct: 1044 QERERQYREEEELQQEEEQLLGEERETRRRQ--ELERQYRKEEELQQEEEQLLREEPE-- 1099

Query: 1516 IQRLKSSLEEESRSKRELDVEVSRL------EARLSELE----FHNSKSSKELDFLREEN 1565
             +R +   E + R + EL  E  +L      + R  ELE           +E   LREE 
Sbjct: 1100 -KRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP 1158

Query: 1566 HK---LQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDL 1622
             K    +LERQ    E   LQ E      E ++ R             R +  E EL   
Sbjct: 1159 EKRRRQELERQ--YREEEELQQEEEQLLREEQEKRR--------QERERQYREEEELQRQ 1208

Query: 1623 KRLSKDKD 1630
            KR  + +D
Sbjct: 1209 KRKQRYRD 1216



 Score =  155 bits (392), Expect = 3e-37
 Identities = 182/808 (22%), Positives = 366/808 (45%), Gaps = 66/808 (8%)

Query: 898  ELDEETERRRQLENEVKSTQ-EEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRT 956
            E +E++E++ +LE   +  + EE+W  R +  +    R E          EE  Q  +  
Sbjct: 150  EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAE----------EEQLQSCKGH 199

Query: 957  LAEE-QHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLRE 1015
              EE   + QL + EL  L+ + R  +Q+ R   Q+ V +E    E ++        LR+
Sbjct: 200  ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQE----EEEKEWRKRETVLRK 255

Query: 1016 ELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQL----EAEYQ 1071
            E E L+ ++  R+ E+   ++++  L  ++ R + +  E++  +L+ + QL    E E +
Sbjct: 256  EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315

Query: 1072 QLQEDHQRQDQLREKQEE--ELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATERE 1129
            + QE+ + Q + RE+QEE  E    +++ +R E++    + +   ++ L+ E++     +
Sbjct: 316  EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375

Query: 1130 VSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQE--------KVREIVRPD 1181
                 +Q   E    R  Q  + + LR+   L  E      Q+        + +E  R +
Sbjct: 376  QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHE 435

Query: 1182 PKAESEVANLRLELVEQERK--YRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYK 1239
             K E E    RL+  ++ER+   +  EE  R  Q   +   +R  + E +E   ++ + +
Sbjct: 436  QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495

Query: 1240 TDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQ 1299
               + E+  Q+LR E  ++     +   E  +L++ +++ +  + + + +   +++L+ +
Sbjct: 496  RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR--EQLLKRE 553

Query: 1300 EDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYE 1359
            E+ + ++E    R K  +E+++   L+RE   +++++ R++EE  R+++R+ ++EV R E
Sbjct: 554  EEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEE--RLEQRLKREEVERLE 611

Query: 1360 EEPGLRAEASAFAESIDVELR--------QIDKLRAELRRLQRRRTELERQLEELERERQ 1411
            +E   R E     E  + E R        Q ++ + +LRR Q+ R E   + EE E   +
Sbjct: 612  QEE--RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLE 669

Query: 1412 ARREAEREVQRLQQRLAALEQEEAEAREKVTHTQ---KVVLQQDPQQAREHALLRLQLEE 1468
             R + E E +R +Q LA  EQE+A  R K    +   ++  + D +Q++ ++  R + +E
Sbjct: 670  QRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS--RPRKQE 727

Query: 1469 EQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESR 1528
             Q RRQ    E E  RR+  +  + + +E+    +  + ++ D   + Q    + E+  R
Sbjct: 728  GQRRRQ----EQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQ----AEEKSER 779

Query: 1529 SKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINM 1588
             ++ L       E R  +L     +  +E  FL EE  K Q  RQ      R  + E+  
Sbjct: 780  GRQRLSARPPLREQRERQLR-AEERQQREQRFLPEEEEKEQRRRQR-----REREKELQF 833

Query: 1589 AATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKRE 1648
               E +  R           D      ER     +R  +    +++E +KR       + 
Sbjct: 834  LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKP 893

Query: 1649 QRENHLRRSIVVIHPDTGRELSPEEAHR 1676
              +  LR+   ++  +   EL  EE  +
Sbjct: 894  ALQEQLRKEQQLLQEEE-EELQREEREK 920



 Score =  135 bits (339), Expect = 5e-31
 Identities = 163/622 (26%), Positives = 293/622 (47%), Gaps = 71/622 (11%)

Query: 1102 EKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWAL 1161
            E++RA  +GK ++ +  + E+D   +R      RQ E+E  + R  +R++ E  R++   
Sbjct: 97   EEKRARCDGKESLLQDRRQEED---QRRFEPRDRQLEEEPGQRRRQKRQEQE--RELAEG 151

Query: 1162 EEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQS------- 1214
            EE++ K   QE++ +  R   + + E+   R E  E+E + R  EEQL+S +        
Sbjct: 152  EEQSEK---QERLEQ--RDRQRRDEELWRQRQEWQEREER-RAEEEQLQSCKGHETEEFP 205

Query: 1215 --------ELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCD 1266
                    EL  LRR+G   E K+  +   + +   E E++  R RE ++ K    E+  
Sbjct: 206  DEEQLRRRELLELRRKGR--EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEE--EKLQ 261

Query: 1267 LEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLE 1326
             E  Q ++E+Q  ++   +++ +E+ +E  + ++  Q       LR K  EE+++Q +  
Sbjct: 262  EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321

Query: 1327 RERASQ-EEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKL 1385
            RE+  + E+Q  R+E++L R +E   +Q++ R +EE   R E     E  +    Q  + 
Sbjct: 322  REQQERREQQEERREQQLRREQEERREQQLRREQEEE--RREQQLRREQEEERREQQLRR 379

Query: 1386 RAELRRLQRRRTELE-RQLEELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHT 1444
              +LRR Q+ R E + R+ ++L RE+Q RRE +   ++  +R   L +E+ E R +  H 
Sbjct: 380  EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439

Query: 1445 QKVVLQ--QDPQQAREHALLRLQ----LEEEQHRRQLLEGELETLRRKLAALEKAEVKEK 1498
            Q+   Q  +  Q+ R   L R +     E+E+ ++QL   + E  R +   LE+ E +E+
Sbjct: 440  QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499

Query: 1499 VVLSESVQVEKGDTEQEIQRLKSSLEEES-----RSKRELDVE--------VSRLEARLS 1545
                E  Q+ +   E+  QRLK   EEE      RS+++L  E        + R E +  
Sbjct: 500  QERREQ-QLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRL 558

Query: 1546 ELEFHNSKSSKELDFLREENHKLQLER--------QNLQLETRRLQSEINMAATETRDLR 1597
            E E    +  +E +  R++  K + ER        Q  +LE R  + E+     E R  R
Sbjct: 559  EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER--R 616

Query: 1598 NMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRS 1657
               +       + R   L+ E  + +R  + +  + +  ++RL     KRE+ E  L + 
Sbjct: 617  EQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRL-----KREEEEERLEQR 671

Query: 1658 IVVIHPDTGR--ELSPEEAHRA 1677
            +   H +  R  EL+ EE  +A
Sbjct: 672  LKREHEEERREQELAEEEQEQA 693


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  165 bits (417), Expect = 4e-40
 Identities = 267/1216 (21%), Positives = 516/1216 (42%), Gaps = 141/1216 (11%)

Query: 416  LISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQ 475
            +I R  +  L+  N + W L       L        +   + E  A  D L  + +  +Q
Sbjct: 818  VIQRNCAAYLKLRNWQWWRLFTKVKPLL-------QVTRQEEEMQAKEDEL-QKTKERQQ 869

Query: 476  KAAGSKRTLQQRYEVLKTENPGDASDLQGR-QLLAGLDKVASDLDRQEKAITGIL----- 529
            KA    + L+Q++  L  E       LQ   +L A  +++   L  +++ +  IL     
Sbjct: 870  KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEA 929

Query: 530  RPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTR 589
            R   E+ R  Q  AER    K +  ++L +E +      E EA  Q L       L +  
Sbjct: 930  RLEEEEDRGQQLQAER----KKMAQQMLDLEEQ----LEEEEAARQKLQ------LEKVT 975

Query: 590  VEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLD 649
             E   +K E  + ++D      D  N+L K  +   E ++    +L +++   ++   L 
Sbjct: 976  AEAKIKKLEDEILVMD------DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029

Query: 650  SKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQ 709
            +K +   +M  EL+ +     +  Q L+  K+     AS F E   DL+ Q AE      
Sbjct: 1030 NKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE------ 1080

Query: 710  RFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKN 769
                L+ Q+ ++ + LQ+A A  +                        D ++Q    LK 
Sbjct: 1081 ----LKMQLAKKEEELQAALARLD------------------------DEIAQKNNALKK 1112

Query: 770  QKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLL-DLENGRSSHVSKRARL 828
             + L   I+  ++++    A   + ++  +D   E E L++ L D  +  ++    RA+ 
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172

Query: 829  QSPATKVK----EEEAALAAKFTEVYAINRQRLQNLEFALNLL-RQQPEVEVTHETLQRN 883
            +   T +K    EE  +  A+  E+   + Q ++ L   L    R +  ++   +TL++ 
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232

Query: 884  RPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPD 943
              D        +  EL    + ++++E++ K  + ++  L+++       R E+  KV  
Sbjct: 1233 NAD--------LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK 1284

Query: 944  PVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLR----ALEQETRDGGQEYVVKEVLR 999
              L+   + +   L E + K   L +++ +L  QL+     L++ETR   Q+  V   LR
Sbjct: 1285 --LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR---QKLNVSTKLR 1339

Query: 1000 -IEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVV 1058
             +E +R    +  QL EE+EA  +Q   R    L +Q     L++ K + Q+  +  E +
Sbjct: 1340 QLEEERNSLQD--QLDEEMEA--KQNLERHISTLNIQ-----LSDSKKKLQDFASTVEAL 1390

Query: 1059 ---KLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVK 1115
               K +   ++E   QQ +E     D+L + +      L D +  L+ +R +       K
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN--LEK 1448

Query: 1116 EVLKVEKDAATEREVSDLTRQYEDEAAKARASQREK-TELLRKIWALEEENAKVVVQEKV 1174
            +  K ++  A E+ +S    +Y DE  +A A  REK T+ L    ALEE        E+ 
Sbjct: 1449 KQRKFDQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505

Query: 1175 REIVRPDPK-AESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTK 1233
             ++++ + +   S   ++   + E E+  R  E Q+   +++LE L       E  ++  
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565

Query: 1234 EVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQ 1293
            EV       + E++LQ   E+  +K R ++R  L  Y+ + E +  +        K++  
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQR-QLHEYETELEDERKQRALAAAAKKKLEG 1624

Query: 1294 EI--LQFQEDPQTK---EEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVK- 1347
            ++  L+ Q D   K   E +  LR   ++ +  Q +LE  RAS++E  A  +E   + K 
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684

Query: 1348 ---ERVVQQEVVRYEEEPGLRA--EASAFAESIDVELRQIDKLRAELRRLQRRRTELERQ 1402
               + +  QE +   E    +A  E    AE +   L   + L+ E RRL+ R  +LE +
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744

Query: 1403 LEELERERQARREAEREV-QRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHAL 1461
            LEE +   +A  +  R+  Q+ +Q    L  E + A++  +  Q++  Q    +++ H  
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH-- 1802

Query: 1462 LRLQLEEEQHRRQLLEGELETLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518
                 E E   +   +  +  L  K+A LE+    E +EK   ++S++ +    +++++ 
Sbjct: 1803 -----EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK----DKKLKE 1853

Query: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578
            +   +E+E +   +   +  +  AR+ +L+    ++ +E   +     KLQ E       
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913

Query: 1579 TRRLQSEINMAATETR 1594
               +  E+N   ++ R
Sbjct: 1914 NEAMGREVNALKSKLR 1929



 Score =  162 bits (411), Expect = 2e-39
 Identities = 245/1137 (21%), Positives = 483/1137 (42%), Gaps = 186/1137 (16%)

Query: 584  PLLR-TRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVP 642
            PLL+ TR E+  +  E  LQ     Q+K +  N L++  Q+  +L  T E +L Q+    
Sbjct: 843  PLLQVTRQEEEMQAKEDELQKTKERQQKAE--NELKELEQKHSQL--TEEKNLLQEQLQA 898

Query: 643  ESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEA 702
            E+    +++      M   L A+K  L E+   ++A          R +E     ++ +A
Sbjct: 899  ETELYAEAE-----EMRVRLAAKKQELEEILHEMEA----------RLEEEEDRGQQLQA 943

Query: 703  EVHKLGQRFNNLRQQVERRA---QSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDS 759
            E  K+ Q+  +L +Q+E      Q LQ  K   E               I   E  E   
Sbjct: 944  ERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE-------------AKIKKLE-DEILV 989

Query: 760  LSQMETKLKNQKNLLDE--------IASREQEVQKICANSQQYQQAVKDYELEAEKLRSL 811
            +     KL  ++ LL+E        +A  E++ + +     +++  + + E+  +K    
Sbjct: 990  MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE--- 1046

Query: 812  LDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQP 871
               E  R      + +L+  A+   E+ A L A+  E+     ++ + L+ AL   R   
Sbjct: 1047 ---EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL--ARLDD 1101

Query: 872  EVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQES 931
            E+   +  L++ R   G      ++++LD E   R + E + +   EE+  L+ +     
Sbjct: 1102 EIAQKNNALKKIRELEG--HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE----- 1154

Query: 932  VVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQE 991
                                 L+ TL     + +L  +  + + +  +AL++ETR    E
Sbjct: 1155 ---------------------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRS--HE 1191

Query: 992  YVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEK---SRA 1048
              V+E+ +       A  V +L E+LE  +R K   +     L++  A LA E     +A
Sbjct: 1192 AQVQEMRQ-----KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246

Query: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMA 1108
            +++V  K+        +LEA+ Q+LQ      ++ R +  +++  LQ++++ +      A
Sbjct: 1247 KQEVEHKK-------KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299

Query: 1109 EGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKV 1168
            EGK      +K+ KD A+      L+ Q +D     +   R+K  +  K+  LEEE   +
Sbjct: 1300 EGK-----AIKLAKDVAS------LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1348

Query: 1169 VVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEV 1228
              Q+++ E +      E  ++ L ++L + ++K       L+ + S +EAL         
Sbjct: 1349 --QDQLDEEMEAKQNLERHISTLNIQLSDSKKK-------LQDFASTVEALE-------- 1391

Query: 1229 KEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALK-DTKPQVQ 1287
                      +     +KE++ L ++  +K    ++ +    +L++E+  L  D   Q Q
Sbjct: 1392 ----------EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441

Query: 1288 TKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVK 1347
                +++  + ++  Q   E  ++ +K ++E+ +     RE+ ++   +AR  EE    K
Sbjct: 1442 LVSNLEK--KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499

Query: 1348 ERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELE 1407
            E + +   +       L+AE      S D   + + +L    R L+ +  E++ QLEELE
Sbjct: 1500 EELERTNKM-------LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552

Query: 1408 RERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLE 1467
             E QA  +A+  ++   Q L    + + +AR++    ++  LQ   +Q  E+     +LE
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ---RQLHEY---ETELE 1606

Query: 1468 EEQHRRQL-------LEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLK 1520
            +E+ +R L       LEG+L+ L  +  +  K   +E +     +Q +  D ++E++  +
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGR-EEAIKQLRKLQAQMKDFQRELEDAR 1665

Query: 1521 SSLEEESRSKRELDVEVSRLEARLSELE---FHNSKSSKELDFLREE-----------NH 1566
            +S +E   + +E + +   LEA L +L+       ++ K+ D  +EE            +
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725

Query: 1567 KLQLERQNLQLETRRLQSEI-----NMAATETRDLRNMTVADSGTN----HDSRLWSLER 1617
             LQ E++ L+    +L+ E+     NM A   R  +    A+  +N      S     E 
Sbjct: 1726 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1785

Query: 1618 ELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEA 1674
                L+R +K+   ++ E++   G+V  K +     L   I  +     +E   ++A
Sbjct: 1786 ARQQLERQNKELRSKLHEME---GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1839



 Score =  117 bits (293), Expect = 1e-25
 Identities = 267/1234 (21%), Positives = 507/1234 (41%), Gaps = 206/1234 (16%)

Query: 206  QARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEA 265
            QA++  L   ++  Q+  NEL  L+Q+                 S+  + +N +   L+A
Sbjct: 855  QAKEDELQKTKERQQKAENELKELEQK----------------HSQLTEEKNLLQEQLQA 898

Query: 266  KEERINKLHSEGDQL---LAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHL--KYME 320
            + E    L++E +++   LAA+      I   MEA   + ++    L  E   +  + ++
Sbjct: 899  ETE----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954

Query: 321  DYHQFHEDVKDAQEL-LRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDK----YE 375
               Q  E+    Q+L L KV ++   K       + + E+L+  +DDQ   L K     E
Sbjct: 955  LEEQLEEEEAARQKLQLEKVTAEAKIK-------KLEDEILV--MDDQNNKLSKERKLLE 1005

Query: 376  DVVQGL-------QKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKN 428
            + +  L       +++ + +  LK + E+ +  + V                      K 
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL--------------------KK 1045

Query: 429  NGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRY 488
              +S + ++    KL   A  F       E +A    L +Q   ++ + A  +  LQ   
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDF------HEQIA---DLQAQIAELKMQLAKKEEELQAAL 1096

Query: 489  EVLKTENPGDASDLQG-RQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAK 547
              L  E     + L+  R+L   +  +  DLD +               RA ++ AE+ K
Sbjct: 1097 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE---------------RAARNKAEKQK 1141

Query: 548  DLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLA 607
                   E L+ E E T  +   +  ++A      T L +   E+T     H  Q+ ++ 
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR---SHEAQVQEMR 1198

Query: 608  QEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKS 667
            Q+       L + L+Q     A                  LD   Q L     +L  +  
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKAN-----------------LDKNKQTLEKENADLAGELR 1241

Query: 668  LLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQS 727
            +LG+ +Q ++  K+         Q  C D ER  AE   L  + + L+ +VE     L  
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLNE 1298

Query: 728  AKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKI 787
            A+        G    L   V+  S + Q+T  L Q ET+ K   N+  ++   E+E    
Sbjct: 1299 AE--------GKAIKLAKDVASLSSQLQDTQELLQEETRQK--LNVSTKLRQLEEE---- 1344

Query: 788  CANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFT 847
              NS Q Q    D E+EA++     +LE     H+S    +Q   +K K ++ A     +
Sbjct: 1345 -RNSLQDQ---LDEEMEAKQ-----NLER----HIS-TLNIQLSDSKKKLQDFA-----S 1385

Query: 848  EVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDE---ETE 904
             V A+   + +  +   NL +Q  E    ++ L++ +         ++++ELD+   + +
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN--------RLQQELDDLVVDLD 1437

Query: 905  RRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKN 964
             +RQL + ++  Q +   L  +    S    +   +      E+  + L  +LA    + 
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL--SLARALEEA 1495

Query: 965  QLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPD-RAQADEVLQLREELEALRRQ 1023
               +EELE     L+A E E     ++ V K V  +E   RA   ++ +++ +LE L  +
Sbjct: 1496 LEAKEELERTNKMLKA-EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554

Query: 1024 KGAREAEVLLLQQRVAALAEEKSR-AQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQ 1082
              A E   L L+  + AL  +  R  Q +  + E  + Q   QL  EY+   ED ++Q  
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH-EYETELEDERKQRA 1613

Query: 1083 L----REKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAAT-EREVSDLTRQY 1137
            L    ++K E +L  L+     L+ + A+   +  +K++ K++      +RE+ D     
Sbjct: 1614 LAAAAKKKLEGDLKDLE-----LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1668

Query: 1138 EDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANL--RLEL 1195
            ++  A A+ ++++   L   +  L+E+ A      K  ++ + +  AE   ++L  R  L
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNAL 1727

Query: 1196 VEQERKYRG----AEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRL 1251
             +++R+        EE+L   Q  +EA+  R     V++ T++  +   +   E+   + 
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDR-----VRKATQQAEQLSNELATERSTAQK 1782

Query: 1252 REEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQE--DPQTKEEVA 1309
             E      + +ER + E+     E++    +K +     +  +I Q +E  + + +E+ A
Sbjct: 1783 NE---SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1839

Query: 1310 SLRAKLSEEQKK------QVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEE-- 1361
            + ++ L ++ KK      QV+ ER+ A Q ++ A K    +RVK+   Q E    E +  
Sbjct: 1840 ATKS-LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN--ARVKQLKRQLEEAEEESQRI 1896

Query: 1362 ----PGLRAEASAFAESIDVELRQIDKLRAELRR 1391
                  L+ E     ES +   R+++ L+++LRR
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 93/399 (23%), Positives = 160/399 (40%), Gaps = 54/399 (13%)

Query: 23   SNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGR-QPEHRDVTLQKVLDSEKL 81
            +NK L   +E L  + D V KN+ + E   ++   +++E + Q E  +  LQ   D++  
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564

Query: 82   LYV----LEADAAIAKHMKHPQGDMIAEDI-RQLKERVTNLRGKHKQIYRLA-------- 128
            L V    L+         +  Q +     + RQL E  T L  + KQ    A        
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624

Query: 129  -VKEVDPQVNWAALVEE----KLDKLNNQSFGTDLPLVDHQVEEHNIF----HNEVKAIG 179
             +K+++ Q + A    E    +L KL  Q       L D +     IF     NE KA  
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA-- 1682

Query: 180  PHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQY 239
                    K   ++L    + L AA +AR+Q     ++  +   + L        GR   
Sbjct: 1683 --------KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL-------SGRNAL 1727

Query: 240  DWSDRNLDYPSRRRQYENFINR---NLEAKEERINKLHSEGDQL---LAAEHPGRNSIEA 293
                R L+  +R  Q E  +     N+EA  +R+ K   + +QL   LA E       E+
Sbjct: 1728 QDEKRRLE--ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1785

Query: 294  HMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGP---- 349
              + +    KE  + L   E  +K          + K AQ L  +V+ +  +K       
Sbjct: 1786 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ-LEEQVEQEAREKQAATKSL 1844

Query: 350  DFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQV 388
              KD+   E+LL +++D+ K+ ++Y++  +    R +Q+
Sbjct: 1845 KQKDKKLKEILL-QVEDERKMAEQYKEQAEKGNARVKQL 1882


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  165 bits (417), Expect = 4e-40
 Identities = 267/1216 (21%), Positives = 516/1216 (42%), Gaps = 141/1216 (11%)

Query: 416  LISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQ 475
            +I R  +  L+  N + W L       L        +   + E  A  D L  + +  +Q
Sbjct: 825  VIQRNCAAYLKLRNWQWWRLFTKVKPLL-------QVTRQEEEMQAKEDEL-QKTKERQQ 876

Query: 476  KAAGSKRTLQQRYEVLKTENPGDASDLQGR-QLLAGLDKVASDLDRQEKAITGIL----- 529
            KA    + L+Q++  L  E       LQ   +L A  +++   L  +++ +  IL     
Sbjct: 877  KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEA 936

Query: 530  RPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTR 589
            R   E+ R  Q  AER    K +  ++L +E +      E EA  Q L       L +  
Sbjct: 937  RLEEEEDRGQQLQAER----KKMAQQMLDLEEQ----LEEEEAARQKLQ------LEKVT 982

Query: 590  VEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLD 649
             E   +K E  + ++D      D  N+L K  +   E ++    +L +++   ++   L 
Sbjct: 983  AEAKIKKLEDEILVMD------DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036

Query: 650  SKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQ 709
            +K +   +M  EL+ +     +  Q L+  K+     AS F E   DL+ Q AE      
Sbjct: 1037 NKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE------ 1087

Query: 710  RFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKN 769
                L+ Q+ ++ + LQ+A A  +                        D ++Q    LK 
Sbjct: 1088 ----LKMQLAKKEEELQAALARLD------------------------DEIAQKNNALKK 1119

Query: 770  QKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLL-DLENGRSSHVSKRARL 828
             + L   I+  ++++    A   + ++  +D   E E L++ L D  +  ++    RA+ 
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179

Query: 829  QSPATKVK----EEEAALAAKFTEVYAINRQRLQNLEFALNLL-RQQPEVEVTHETLQRN 883
            +   T +K    EE  +  A+  E+   + Q ++ L   L    R +  ++   +TL++ 
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239

Query: 884  RPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPD 943
              D        +  EL    + ++++E++ K  + ++  L+++       R E+  KV  
Sbjct: 1240 NAD--------LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK 1291

Query: 944  PVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLR----ALEQETRDGGQEYVVKEVLR 999
              L+   + +   L E + K   L +++ +L  QL+     L++ETR   Q+  V   LR
Sbjct: 1292 --LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR---QKLNVSTKLR 1346

Query: 1000 -IEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVV 1058
             +E +R    +  QL EE+EA  +Q   R    L +Q     L++ K + Q+  +  E +
Sbjct: 1347 QLEEERNSLQD--QLDEEMEA--KQNLERHISTLNIQ-----LSDSKKKLQDFASTVEAL 1397

Query: 1059 ---KLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVK 1115
               K +   ++E   QQ +E     D+L + +      L D +  L+ +R +       K
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN--LEK 1455

Query: 1116 EVLKVEKDAATEREVSDLTRQYEDEAAKARASQREK-TELLRKIWALEEENAKVVVQEKV 1174
            +  K ++  A E+ +S    +Y DE  +A A  REK T+ L    ALEE        E+ 
Sbjct: 1456 KQRKFDQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

Query: 1175 REIVRPDPK-AESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTK 1233
             ++++ + +   S   ++   + E E+  R  E Q+   +++LE L       E  ++  
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572

Query: 1234 EVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQ 1293
            EV       + E++LQ   E+  +K R ++R  L  Y+ + E +  +        K++  
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQR-QLHEYETELEDERKQRALAAAAKKKLEG 1631

Query: 1294 EI--LQFQEDPQTK---EEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVK- 1347
            ++  L+ Q D   K   E +  LR   ++ +  Q +LE  RAS++E  A  +E   + K 
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691

Query: 1348 ---ERVVQQEVVRYEEEPGLRA--EASAFAESIDVELRQIDKLRAELRRLQRRRTELERQ 1402
               + +  QE +   E    +A  E    AE +   L   + L+ E RRL+ R  +LE +
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751

Query: 1403 LEELERERQARREAEREV-QRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHAL 1461
            LEE +   +A  +  R+  Q+ +Q    L  E + A++  +  Q++  Q    +++ H  
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH-- 1809

Query: 1462 LRLQLEEEQHRRQLLEGELETLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518
                 E E   +   +  +  L  K+A LE+    E +EK   ++S++ +    +++++ 
Sbjct: 1810 -----EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK----DKKLKE 1860

Query: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578
            +   +E+E +   +   +  +  AR+ +L+    ++ +E   +     KLQ E       
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920

Query: 1579 TRRLQSEINMAATETR 1594
               +  E+N   ++ R
Sbjct: 1921 NEAMGREVNALKSKLR 1936



 Score =  162 bits (411), Expect = 2e-39
 Identities = 245/1137 (21%), Positives = 483/1137 (42%), Gaps = 186/1137 (16%)

Query: 584  PLLR-TRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVP 642
            PLL+ TR E+  +  E  LQ     Q+K +  N L++  Q+  +L  T E +L Q+    
Sbjct: 850  PLLQVTRQEEEMQAKEDELQKTKERQQKAE--NELKELEQKHSQL--TEEKNLLQEQLQA 905

Query: 643  ESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEA 702
            E+    +++      M   L A+K  L E+   ++A          R +E     ++ +A
Sbjct: 906  ETELYAEAE-----EMRVRLAAKKQELEEILHEMEA----------RLEEEEDRGQQLQA 950

Query: 703  EVHKLGQRFNNLRQQVERRA---QSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDS 759
            E  K+ Q+  +L +Q+E      Q LQ  K   E               I   E  E   
Sbjct: 951  ERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE-------------AKIKKLE-DEILV 996

Query: 760  LSQMETKLKNQKNLLDE--------IASREQEVQKICANSQQYQQAVKDYELEAEKLRSL 811
            +     KL  ++ LL+E        +A  E++ + +     +++  + + E+  +K    
Sbjct: 997  MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE--- 1053

Query: 812  LDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQP 871
               E  R      + +L+  A+   E+ A L A+  E+     ++ + L+ AL   R   
Sbjct: 1054 ---EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL--ARLDD 1108

Query: 872  EVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQES 931
            E+   +  L++ R   G      ++++LD E   R + E + +   EE+  L+ +     
Sbjct: 1109 EIAQKNNALKKIRELEG--HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE----- 1161

Query: 932  VVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQE 991
                                 L+ TL     + +L  +  + + +  +AL++ETR    E
Sbjct: 1162 ---------------------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRS--HE 1198

Query: 992  YVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEK---SRA 1048
              V+E+ +       A  V +L E+LE  +R K   +     L++  A LA E     +A
Sbjct: 1199 AQVQEMRQ-----KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253

Query: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMA 1108
            +++V  K+        +LEA+ Q+LQ      ++ R +  +++  LQ++++ +      A
Sbjct: 1254 KQEVEHKK-------KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306

Query: 1109 EGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKV 1168
            EGK      +K+ KD A+      L+ Q +D     +   R+K  +  K+  LEEE   +
Sbjct: 1307 EGK-----AIKLAKDVAS------LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1355

Query: 1169 VVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEV 1228
              Q+++ E +      E  ++ L ++L + ++K       L+ + S +EAL         
Sbjct: 1356 --QDQLDEEMEAKQNLERHISTLNIQLSDSKKK-------LQDFASTVEALE-------- 1398

Query: 1229 KEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALK-DTKPQVQ 1287
                      +     +KE++ L ++  +K    ++ +    +L++E+  L  D   Q Q
Sbjct: 1399 ----------EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448

Query: 1288 TKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVK 1347
                +++  + ++  Q   E  ++ +K ++E+ +     RE+ ++   +AR  EE    K
Sbjct: 1449 LVSNLEK--KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506

Query: 1348 ERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELE 1407
            E + +   +       L+AE      S D   + + +L    R L+ +  E++ QLEELE
Sbjct: 1507 EELERTNKM-------LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559

Query: 1408 RERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLE 1467
             E QA  +A+  ++   Q L    + + +AR++    ++  LQ   +Q  E+     +LE
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ---RQLHEY---ETELE 1613

Query: 1468 EEQHRRQL-------LEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLK 1520
            +E+ +R L       LEG+L+ L  +  +  K   +E +     +Q +  D ++E++  +
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGR-EEAIKQLRKLQAQMKDFQRELEDAR 1672

Query: 1521 SSLEEESRSKRELDVEVSRLEARLSELE---FHNSKSSKELDFLREE-----------NH 1566
            +S +E   + +E + +   LEA L +L+       ++ K+ D  +EE            +
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732

Query: 1567 KLQLERQNLQLETRRLQSEI-----NMAATETRDLRNMTVADSGTN----HDSRLWSLER 1617
             LQ E++ L+    +L+ E+     NM A   R  +    A+  +N      S     E 
Sbjct: 1733 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1792

Query: 1618 ELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEA 1674
                L+R +K+   ++ E++   G+V  K +     L   I  +     +E   ++A
Sbjct: 1793 ARQQLERQNKELRSKLHEME---GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1846



 Score =  117 bits (293), Expect = 1e-25
 Identities = 267/1234 (21%), Positives = 507/1234 (41%), Gaps = 206/1234 (16%)

Query: 206  QARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEA 265
            QA++  L   ++  Q+  NEL  L+Q+                 S+  + +N +   L+A
Sbjct: 862  QAKEDELQKTKERQQKAENELKELEQK----------------HSQLTEEKNLLQEQLQA 905

Query: 266  KEERINKLHSEGDQL---LAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHL--KYME 320
            + E    L++E +++   LAA+      I   MEA   + ++    L  E   +  + ++
Sbjct: 906  ETE----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961

Query: 321  DYHQFHEDVKDAQEL-LRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDK----YE 375
               Q  E+    Q+L L KV ++   K       + + E+L+  +DDQ   L K     E
Sbjct: 962  LEEQLEEEEAARQKLQLEKVTAEAKIK-------KLEDEILV--MDDQNNKLSKERKLLE 1012

Query: 376  DVVQGL-------QKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKN 428
            + +  L       +++ + +  LK + E+ +  + V                      K 
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL--------------------KK 1052

Query: 429  NGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRY 488
              +S + ++    KL   A  F       E +A    L +Q   ++ + A  +  LQ   
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDF------HEQIA---DLQAQIAELKMQLAKKEEELQAAL 1103

Query: 489  EVLKTENPGDASDLQG-RQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAK 547
              L  E     + L+  R+L   +  +  DLD +               RA ++ AE+ K
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE---------------RAARNKAEKQK 1148

Query: 548  DLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLA 607
                   E L+ E E T  +   +  ++A      T L +   E+T     H  Q+ ++ 
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR---SHEAQVQEMR 1205

Query: 608  QEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKS 667
            Q+       L + L+Q     A                  LD   Q L     +L  +  
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKAN-----------------LDKNKQTLEKENADLAGELR 1248

Query: 668  LLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQS 727
            +LG+ +Q ++  K+         Q  C D ER  AE   L  + + L+ +VE     L  
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLNE 1305

Query: 728  AKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKI 787
            A+        G    L   V+  S + Q+T  L Q ET+ K   N+  ++   E+E    
Sbjct: 1306 AE--------GKAIKLAKDVASLSSQLQDTQELLQEETRQK--LNVSTKLRQLEEE---- 1351

Query: 788  CANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFT 847
              NS Q Q    D E+EA++     +LE     H+S    +Q   +K K ++ A     +
Sbjct: 1352 -RNSLQDQ---LDEEMEAKQ-----NLER----HIS-TLNIQLSDSKKKLQDFA-----S 1392

Query: 848  EVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDE---ETE 904
             V A+   + +  +   NL +Q  E    ++ L++ +         ++++ELD+   + +
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN--------RLQQELDDLVVDLD 1444

Query: 905  RRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKN 964
             +RQL + ++  Q +   L  +    S    +   +      E+  + L  +LA    + 
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL--SLARALEEA 1502

Query: 965  QLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPD-RAQADEVLQLREELEALRRQ 1023
               +EELE     L+A E E     ++ V K V  +E   RA   ++ +++ +LE L  +
Sbjct: 1503 LEAKEELERTNKMLKA-EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561

Query: 1024 KGAREAEVLLLQQRVAALAEEKSR-AQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQ 1082
              A E   L L+  + AL  +  R  Q +  + E  + Q   QL  EY+   ED ++Q  
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH-EYETELEDERKQRA 1620

Query: 1083 L----REKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAAT-EREVSDLTRQY 1137
            L    ++K E +L  L+     L+ + A+   +  +K++ K++      +RE+ D     
Sbjct: 1621 LAAAAKKKLEGDLKDLE-----LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1675

Query: 1138 EDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANL--RLEL 1195
            ++  A A+ ++++   L   +  L+E+ A      K  ++ + +  AE   ++L  R  L
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNAL 1734

Query: 1196 VEQERKYRG----AEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRL 1251
             +++R+        EE+L   Q  +EA+  R     V++ T++  +   +   E+   + 
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDR-----VRKATQQAEQLSNELATERSTAQK 1789

Query: 1252 REEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQE--DPQTKEEVA 1309
             E      + +ER + E+     E++    +K +     +  +I Q +E  + + +E+ A
Sbjct: 1790 NE---SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1846

Query: 1310 SLRAKLSEEQKK------QVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEE-- 1361
            + ++ L ++ KK      QV+ ER+ A Q ++ A K    +RVK+   Q E    E +  
Sbjct: 1847 ATKS-LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN--ARVKQLKRQLEEAEEESQRI 1903

Query: 1362 ----PGLRAEASAFAESIDVELRQIDKLRAELRR 1391
                  L+ E     ES +   R+++ L+++LRR
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 93/399 (23%), Positives = 160/399 (40%), Gaps = 54/399 (13%)

Query: 23   SNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGR-QPEHRDVTLQKVLDSEKL 81
            +NK L   +E L  + D V KN+ + E   ++   +++E + Q E  +  LQ   D++  
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571

Query: 82   LYV----LEADAAIAKHMKHPQGDMIAEDI-RQLKERVTNLRGKHKQIYRLA-------- 128
            L V    L+         +  Q +     + RQL E  T L  + KQ    A        
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631

Query: 129  -VKEVDPQVNWAALVEE----KLDKLNNQSFGTDLPLVDHQVEEHNIF----HNEVKAIG 179
             +K+++ Q + A    E    +L KL  Q       L D +     IF     NE KA  
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA-- 1689

Query: 180  PHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQY 239
                    K   ++L    + L AA +AR+Q     ++  +   + L        GR   
Sbjct: 1690 --------KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL-------SGRNAL 1734

Query: 240  DWSDRNLDYPSRRRQYENFINR---NLEAKEERINKLHSEGDQL---LAAEHPGRNSIEA 293
                R L+  +R  Q E  +     N+EA  +R+ K   + +QL   LA E       E+
Sbjct: 1735 QDEKRRLE--ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1792

Query: 294  HMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGP---- 349
              + +    KE  + L   E  +K          + K AQ L  +V+ +  +K       
Sbjct: 1793 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ-LEEQVEQEAREKQAATKSL 1851

Query: 350  DFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQV 388
              KD+   E+LL +++D+ K+ ++Y++  +    R +Q+
Sbjct: 1852 KQKDKKLKEILL-QVEDERKMAEQYKEQAEKGNARVKQL 1889


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  165 bits (417), Expect = 4e-40
 Identities = 267/1216 (21%), Positives = 516/1216 (42%), Gaps = 141/1216 (11%)

Query: 416  LISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQ 475
            +I R  +  L+  N + W L       L        +   + E  A  D L  + +  +Q
Sbjct: 825  VIQRNCAAYLKLRNWQWWRLFTKVKPLL-------QVTRQEEEMQAKEDEL-QKTKERQQ 876

Query: 476  KAAGSKRTLQQRYEVLKTENPGDASDLQGR-QLLAGLDKVASDLDRQEKAITGIL----- 529
            KA    + L+Q++  L  E       LQ   +L A  +++   L  +++ +  IL     
Sbjct: 877  KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEA 936

Query: 530  RPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTR 589
            R   E+ R  Q  AER    K +  ++L +E +      E EA  Q L       L +  
Sbjct: 937  RLEEEEDRGQQLQAER----KKMAQQMLDLEEQ----LEEEEAARQKLQ------LEKVT 982

Query: 590  VEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLD 649
             E   +K E  + ++D      D  N+L K  +   E ++    +L +++   ++   L 
Sbjct: 983  AEAKIKKLEDEILVMD------DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036

Query: 650  SKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQ 709
            +K +   +M  EL+ +     +  Q L+  K+     AS F E   DL+ Q AE      
Sbjct: 1037 NKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE------ 1087

Query: 710  RFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKN 769
                L+ Q+ ++ + LQ+A A  +                        D ++Q    LK 
Sbjct: 1088 ----LKMQLAKKEEELQAALARLD------------------------DEIAQKNNALKK 1119

Query: 770  QKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLL-DLENGRSSHVSKRARL 828
             + L   I+  ++++    A   + ++  +D   E E L++ L D  +  ++    RA+ 
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179

Query: 829  QSPATKVK----EEEAALAAKFTEVYAINRQRLQNLEFALNLL-RQQPEVEVTHETLQRN 883
            +   T +K    EE  +  A+  E+   + Q ++ L   L    R +  ++   +TL++ 
Sbjct: 1180 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239

Query: 884  RPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPD 943
              D        +  EL    + ++++E++ K  + ++  L+++       R E+  KV  
Sbjct: 1240 NAD--------LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK 1291

Query: 944  PVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLR----ALEQETRDGGQEYVVKEVLR 999
              L+   + +   L E + K   L +++ +L  QL+     L++ETR   Q+  V   LR
Sbjct: 1292 --LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR---QKLNVSTKLR 1346

Query: 1000 -IEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVV 1058
             +E +R    +  QL EE+EA  +Q   R    L +Q     L++ K + Q+  +  E +
Sbjct: 1347 QLEEERNSLQD--QLDEEMEA--KQNLERHISTLNIQ-----LSDSKKKLQDFASTVEAL 1397

Query: 1059 ---KLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVK 1115
               K +   ++E   QQ +E     D+L + +      L D +  L+ +R +       K
Sbjct: 1398 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN--LEK 1455

Query: 1116 EVLKVEKDAATEREVSDLTRQYEDEAAKARASQREK-TELLRKIWALEEENAKVVVQEKV 1174
            +  K ++  A E+ +S    +Y DE  +A A  REK T+ L    ALEE        E+ 
Sbjct: 1456 KQRKFDQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1512

Query: 1175 REIVRPDPK-AESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTK 1233
             ++++ + +   S   ++   + E E+  R  E Q+   +++LE L       E  ++  
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572

Query: 1234 EVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQ 1293
            EV       + E++LQ   E+  +K R ++R  L  Y+ + E +  +        K++  
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQR-QLHEYETELEDERKQRALAAAAKKKLEG 1631

Query: 1294 EI--LQFQEDPQTK---EEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVK- 1347
            ++  L+ Q D   K   E +  LR   ++ +  Q +LE  RAS++E  A  +E   + K 
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1691

Query: 1348 ---ERVVQQEVVRYEEEPGLRA--EASAFAESIDVELRQIDKLRAELRRLQRRRTELERQ 1402
               + +  QE +   E    +A  E    AE +   L   + L+ E RRL+ R  +LE +
Sbjct: 1692 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1751

Query: 1403 LEELERERQARREAEREV-QRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHAL 1461
            LEE +   +A  +  R+  Q+ +Q    L  E + A++  +  Q++  Q    +++ H  
Sbjct: 1752 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH-- 1809

Query: 1462 LRLQLEEEQHRRQLLEGELETLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518
                 E E   +   +  +  L  K+A LE+    E +EK   ++S++ +    +++++ 
Sbjct: 1810 -----EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK----DKKLKE 1860

Query: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578
            +   +E+E +   +   +  +  AR+ +L+    ++ +E   +     KLQ E       
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920

Query: 1579 TRRLQSEINMAATETR 1594
               +  E+N   ++ R
Sbjct: 1921 NEAMGREVNALKSKLR 1936



 Score =  162 bits (411), Expect = 2e-39
 Identities = 245/1137 (21%), Positives = 483/1137 (42%), Gaps = 186/1137 (16%)

Query: 584  PLLR-TRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVP 642
            PLL+ TR E+  +  E  LQ     Q+K +  N L++  Q+  +L  T E +L Q+    
Sbjct: 850  PLLQVTRQEEEMQAKEDELQKTKERQQKAE--NELKELEQKHSQL--TEEKNLLQEQLQA 905

Query: 643  ESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEA 702
            E+    +++      M   L A+K  L E+   ++A          R +E     ++ +A
Sbjct: 906  ETELYAEAE-----EMRVRLAAKKQELEEILHEMEA----------RLEEEEDRGQQLQA 950

Query: 703  EVHKLGQRFNNLRQQVERRA---QSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDS 759
            E  K+ Q+  +L +Q+E      Q LQ  K   E               I   E  E   
Sbjct: 951  ERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE-------------AKIKKLE-DEILV 996

Query: 760  LSQMETKLKNQKNLLDE--------IASREQEVQKICANSQQYQQAVKDYELEAEKLRSL 811
            +     KL  ++ LL+E        +A  E++ + +     +++  + + E+  +K    
Sbjct: 997  MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE--- 1053

Query: 812  LDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQP 871
               E  R      + +L+  A+   E+ A L A+  E+     ++ + L+ AL   R   
Sbjct: 1054 ---EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL--ARLDD 1108

Query: 872  EVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQES 931
            E+   +  L++ R   G      ++++LD E   R + E + +   EE+  L+ +     
Sbjct: 1109 EIAQKNNALKKIRELEG--HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE----- 1161

Query: 932  VVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQE 991
                                 L+ TL     + +L  +  + + +  +AL++ETR    E
Sbjct: 1162 ---------------------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRS--HE 1198

Query: 992  YVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEK---SRA 1048
              V+E+ +       A  V +L E+LE  +R K   +     L++  A LA E     +A
Sbjct: 1199 AQVQEMRQ-----KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253

Query: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMA 1108
            +++V  K+        +LEA+ Q+LQ      ++ R +  +++  LQ++++ +      A
Sbjct: 1254 KQEVEHKK-------KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1306

Query: 1109 EGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKV 1168
            EGK      +K+ KD A+      L+ Q +D     +   R+K  +  K+  LEEE   +
Sbjct: 1307 EGK-----AIKLAKDVAS------LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1355

Query: 1169 VVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEV 1228
              Q+++ E +      E  ++ L ++L + ++K       L+ + S +EAL         
Sbjct: 1356 --QDQLDEEMEAKQNLERHISTLNIQLSDSKKK-------LQDFASTVEALE-------- 1398

Query: 1229 KEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALK-DTKPQVQ 1287
                      +     +KE++ L ++  +K    ++ +    +L++E+  L  D   Q Q
Sbjct: 1399 ----------EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448

Query: 1288 TKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVK 1347
                +++  + ++  Q   E  ++ +K ++E+ +     RE+ ++   +AR  EE    K
Sbjct: 1449 LVSNLEK--KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506

Query: 1348 ERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELE 1407
            E + +   +       L+AE      S D   + + +L    R L+ +  E++ QLEELE
Sbjct: 1507 EELERTNKM-------LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559

Query: 1408 RERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLE 1467
             E QA  +A+  ++   Q L    + + +AR++    ++  LQ   +Q  E+     +LE
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ---RQLHEY---ETELE 1613

Query: 1468 EEQHRRQL-------LEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLK 1520
            +E+ +R L       LEG+L+ L  +  +  K   +E +     +Q +  D ++E++  +
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGR-EEAIKQLRKLQAQMKDFQRELEDAR 1672

Query: 1521 SSLEEESRSKRELDVEVSRLEARLSELE---FHNSKSSKELDFLREE-----------NH 1566
            +S +E   + +E + +   LEA L +L+       ++ K+ D  +EE            +
Sbjct: 1673 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1732

Query: 1567 KLQLERQNLQLETRRLQSEI-----NMAATETRDLRNMTVADSGTN----HDSRLWSLER 1617
             LQ E++ L+    +L+ E+     NM A   R  +    A+  +N      S     E 
Sbjct: 1733 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1792

Query: 1618 ELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEA 1674
                L+R +K+   ++ E++   G+V  K +     L   I  +     +E   ++A
Sbjct: 1793 ARQQLERQNKELRSKLHEME---GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1846



 Score =  116 bits (291), Expect = 2e-25
 Identities = 271/1271 (21%), Positives = 515/1271 (40%), Gaps = 232/1271 (18%)

Query: 206  QARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEA 265
            QA++  L   ++  Q+  NEL  L+Q+                 S+  + +N +   L+A
Sbjct: 862  QAKEDELQKTKERQQKAENELKELEQK----------------HSQLTEEKNLLQEQLQA 905

Query: 266  KEERINKLHSEGDQL---LAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHL--KYME 320
            + E    L++E +++   LAA+      I   MEA   + ++    L  E   +  + ++
Sbjct: 906  ETE----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 961

Query: 321  DYHQFHEDVKDAQEL-LRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDK----YE 375
               Q  E+    Q+L L KV ++   K       + + E+L+  +DDQ   L K     E
Sbjct: 962  LEEQLEEEEAARQKLQLEKVTAEAKIK-------KLEDEILV--MDDQNNKLSKERKLLE 1012

Query: 376  DVVQGL-------QKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKN 428
            + +  L       +++ + +  LK + E+ +  + V                      K 
Sbjct: 1013 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL--------------------KK 1052

Query: 429  NGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRY 488
              +S + ++    KL   A  F       E +A    L +Q   ++ + A  +  LQ   
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDF------HEQIA---DLQAQIAELKMQLAKKEEELQAAL 1103

Query: 489  EVLKTENPGDASDLQG-RQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAK 547
              L  E     + L+  R+L   +  +  DLD +               RA ++ AE+ K
Sbjct: 1104 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE---------------RAARNKAEKQK 1148

Query: 548  DLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLA 607
                   E L+ E E T  +   +  ++A      T L +   E+T     H  Q+ ++ 
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR---SHEAQVQEMR 1205

Query: 608  QEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKS 667
            Q+       L + L+Q     A                  LD   Q L     +L  +  
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKAN-----------------LDKNKQTLEKENADLAGELR 1248

Query: 668  LLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQS 727
            +LG+ +Q ++  K+         Q  C D ER  AE   L  + + L+ +VE     L  
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLNE 1305

Query: 728  AKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKI 787
            A+        G    L   V+  S + Q+T  L Q ET+ K   N+  ++   E+E    
Sbjct: 1306 AE--------GKAIKLAKDVASLSSQLQDTQELLQEETRQK--LNVSTKLRQLEEE---- 1351

Query: 788  CANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFT 847
              NS Q Q    D E+EA++     +LE     H+S    +Q   +K K ++ A     +
Sbjct: 1352 -RNSLQDQ---LDEEMEAKQ-----NLER----HIS-TLNIQLSDSKKKLQDFA-----S 1392

Query: 848  EVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDE---ETE 904
             V A+   + +  +   NL +Q  E    ++ L++ +         ++++ELD+   + +
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN--------RLQQELDDLVVDLD 1444

Query: 905  RRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKN 964
             +RQL + ++  Q +   L  +    S    +   +      E+  + L  +LA    + 
Sbjct: 1445 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL--SLARALEEA 1502

Query: 965  QLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPD-RAQADEVLQLREELEALRRQ 1023
               +EELE     L+A E E     ++ V K V  +E   RA   ++ +++ +LE L  +
Sbjct: 1503 LEAKEELERTNKMLKA-EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561

Query: 1024 KGAREAEVLLLQQRVAALAEEKSR-AQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQ 1082
              A E   L L+  + AL  +  R  Q +  + E  + Q   QL  EY+   ED ++Q  
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH-EYETELEDERKQRA 1620

Query: 1083 L----REKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAAT-EREVSDLTRQY 1137
            L    ++K E +L  L+     L+ + A+   +  +K++ K++      +RE+ D     
Sbjct: 1621 LAAAAKKKLEGDLKDLE-----LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1675

Query: 1138 EDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANL--RLEL 1195
            ++  A A+ ++++   L   +  L+E+ A      K  ++ + +  AE   ++L  R  L
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNAL 1734

Query: 1196 VEQERKYRG----AEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRL 1251
             +++R+        EE+L   Q  +EA+  R     V++ T++  +   +   E+   + 
Sbjct: 1735 QDEKRRLEARIAQLEEELEEEQGNMEAMSDR-----VRKATQQAEQLSNELATERSTAQK 1789

Query: 1252 REEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQE--DPQTKEEVA 1309
             E      + +ER + E+     E++    +K +     +  +I Q +E  + + +E+ A
Sbjct: 1790 NE---SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1846

Query: 1310 SLRAKLSEEQKK------QVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPG 1363
            + ++ L ++ KK      QV+ ER+ A Q ++ A K    +RVK+               
Sbjct: 1847 ATKS-LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN--ARVKQL-------------- 1889

Query: 1364 LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRL 1423
                            RQ+++   E +R+   R +L+R+L+E     +A     REV  L
Sbjct: 1890 ---------------KRQLEEAEEESQRINANRRKLQRELDEATESNEA---MGREVNAL 1931

Query: 1424 QQRLAALEQEE 1434
            + +L     +E
Sbjct: 1932 KSKLRGPPPQE 1942



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 93/399 (23%), Positives = 160/399 (40%), Gaps = 54/399 (13%)

Query: 23   SNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGR-QPEHRDVTLQKVLDSEKL 81
            +NK L   +E L  + D V KN+ + E   ++   +++E + Q E  +  LQ   D++  
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571

Query: 82   LYV----LEADAAIAKHMKHPQGDMIAEDI-RQLKERVTNLRGKHKQIYRLA-------- 128
            L V    L+         +  Q +     + RQL E  T L  + KQ    A        
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631

Query: 129  -VKEVDPQVNWAALVEE----KLDKLNNQSFGTDLPLVDHQVEEHNIF----HNEVKAIG 179
             +K+++ Q + A    E    +L KL  Q       L D +     IF     NE KA  
Sbjct: 1632 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA-- 1689

Query: 180  PHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQY 239
                    K   ++L    + L AA +AR+Q     ++  +   + L        GR   
Sbjct: 1690 --------KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL-------SGRNAL 1734

Query: 240  DWSDRNLDYPSRRRQYENFINR---NLEAKEERINKLHSEGDQL---LAAEHPGRNSIEA 293
                R L+  +R  Q E  +     N+EA  +R+ K   + +QL   LA E       E+
Sbjct: 1735 QDEKRRLE--ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1792

Query: 294  HMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGP---- 349
              + +    KE  + L   E  +K          + K AQ L  +V+ +  +K       
Sbjct: 1793 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ-LEEQVEQEAREKQAATKSL 1851

Query: 350  DFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQV 388
              KD+   E+LL +++D+ K+ ++Y++  +    R +Q+
Sbjct: 1852 KQKDKKLKEILL-QVEDERKMAEQYKEQAEKGNARVKQL 1889


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  165 bits (417), Expect = 4e-40
 Identities = 267/1216 (21%), Positives = 516/1216 (42%), Gaps = 141/1216 (11%)

Query: 416  LISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQ 475
            +I R  +  L+  N + W L       L        +   + E  A  D L  + +  +Q
Sbjct: 818  VIQRNCAAYLKLRNWQWWRLFTKVKPLL-------QVTRQEEEMQAKEDEL-QKTKERQQ 869

Query: 476  KAAGSKRTLQQRYEVLKTENPGDASDLQGR-QLLAGLDKVASDLDRQEKAITGIL----- 529
            KA    + L+Q++  L  E       LQ   +L A  +++   L  +++ +  IL     
Sbjct: 870  KAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEA 929

Query: 530  RPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTR 589
            R   E+ R  Q  AER    K +  ++L +E +      E EA  Q L       L +  
Sbjct: 930  RLEEEEDRGQQLQAER----KKMAQQMLDLEEQ----LEEEEAARQKLQ------LEKVT 975

Query: 590  VEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLD 649
             E   +K E  + ++D      D  N+L K  +   E ++    +L +++   ++   L 
Sbjct: 976  AEAKIKKLEDEILVMD------DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029

Query: 650  SKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQ 709
            +K +   +M  EL+ +     +  Q L+  K+     AS F E   DL+ Q AE      
Sbjct: 1030 NKHE---SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE------ 1080

Query: 710  RFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKN 769
                L+ Q+ ++ + LQ+A A  +                        D ++Q    LK 
Sbjct: 1081 ----LKMQLAKKEEELQAALARLD------------------------DEIAQKNNALKK 1112

Query: 770  QKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLL-DLENGRSSHVSKRARL 828
             + L   I+  ++++    A   + ++  +D   E E L++ L D  +  ++    RA+ 
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172

Query: 829  QSPATKVK----EEEAALAAKFTEVYAINRQRLQNLEFALNLL-RQQPEVEVTHETLQRN 883
            +   T +K    EE  +  A+  E+   + Q ++ L   L    R +  ++   +TL++ 
Sbjct: 1173 EQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232

Query: 884  RPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPD 943
              D        +  EL    + ++++E++ K  + ++  L+++       R E+  KV  
Sbjct: 1233 NAD--------LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK 1284

Query: 944  PVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLR----ALEQETRDGGQEYVVKEVLR 999
              L+   + +   L E + K   L +++ +L  QL+     L++ETR   Q+  V   LR
Sbjct: 1285 --LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR---QKLNVSTKLR 1339

Query: 1000 -IEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVV 1058
             +E +R    +  QL EE+EA  +Q   R    L +Q     L++ K + Q+  +  E +
Sbjct: 1340 QLEEERNSLQD--QLDEEMEA--KQNLERHISTLNIQ-----LSDSKKKLQDFASTVEAL 1390

Query: 1059 ---KLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVK 1115
               K +   ++E   QQ +E     D+L + +      L D +  L+ +R +       K
Sbjct: 1391 EEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN--LEK 1448

Query: 1116 EVLKVEKDAATEREVSDLTRQYEDEAAKARASQREK-TELLRKIWALEEENAKVVVQEKV 1174
            +  K ++  A E+ +S    +Y DE  +A A  REK T+ L    ALEE        E+ 
Sbjct: 1449 KQRKFDQLLAEEKNISS---KYADERDRAEAEAREKETKALSLARALEEALEAKEELERT 1505

Query: 1175 REIVRPDPK-AESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTK 1233
             ++++ + +   S   ++   + E E+  R  E Q+   +++LE L       E  ++  
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565

Query: 1234 EVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQ 1293
            EV       + E++LQ   E+  +K R ++R  L  Y+ + E +  +        K++  
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQR-QLHEYETELEDERKQRALAAAAKKKLEG 1624

Query: 1294 EI--LQFQEDPQTK---EEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVK- 1347
            ++  L+ Q D   K   E +  LR   ++ +  Q +LE  RAS++E  A  +E   + K 
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKS 1684

Query: 1348 ---ERVVQQEVVRYEEEPGLRA--EASAFAESIDVELRQIDKLRAELRRLQRRRTELERQ 1402
               + +  QE +   E    +A  E    AE +   L   + L+ E RRL+ R  +LE +
Sbjct: 1685 LEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEE 1744

Query: 1403 LEELERERQARREAEREV-QRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHAL 1461
            LEE +   +A  +  R+  Q+ +Q    L  E + A++  +  Q++  Q    +++ H  
Sbjct: 1745 LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLH-- 1802

Query: 1462 LRLQLEEEQHRRQLLEGELETLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518
                 E E   +   +  +  L  K+A LE+    E +EK   ++S++ +    +++++ 
Sbjct: 1803 -----EMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQK----DKKLKE 1853

Query: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578
            +   +E+E +   +   +  +  AR+ +L+    ++ +E   +     KLQ E       
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913

Query: 1579 TRRLQSEINMAATETR 1594
               +  E+N   ++ R
Sbjct: 1914 NEAMGREVNALKSKLR 1929



 Score =  162 bits (411), Expect = 2e-39
 Identities = 245/1137 (21%), Positives = 483/1137 (42%), Gaps = 186/1137 (16%)

Query: 584  PLLR-TRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVP 642
            PLL+ TR E+  +  E  LQ     Q+K +  N L++  Q+  +L  T E +L Q+    
Sbjct: 843  PLLQVTRQEEEMQAKEDELQKTKERQQKAE--NELKELEQKHSQL--TEEKNLLQEQLQA 898

Query: 643  ESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEA 702
            E+    +++      M   L A+K  L E+   ++A          R +E     ++ +A
Sbjct: 899  ETELYAEAE-----EMRVRLAAKKQELEEILHEMEA----------RLEEEEDRGQQLQA 943

Query: 703  EVHKLGQRFNNLRQQVERRA---QSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDS 759
            E  K+ Q+  +L +Q+E      Q LQ  K   E               I   E  E   
Sbjct: 944  ERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAE-------------AKIKKLE-DEILV 989

Query: 760  LSQMETKLKNQKNLLDE--------IASREQEVQKICANSQQYQQAVKDYELEAEKLRSL 811
            +     KL  ++ LL+E        +A  E++ + +     +++  + + E+  +K    
Sbjct: 990  MDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKE--- 1046

Query: 812  LDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQP 871
               E  R      + +L+  A+   E+ A L A+  E+     ++ + L+ AL   R   
Sbjct: 1047 ---EKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAAL--ARLDD 1101

Query: 872  EVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQES 931
            E+   +  L++ R   G      ++++LD E   R + E + +   EE+  L+ +     
Sbjct: 1102 EIAQKNNALKKIRELEG--HISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE----- 1154

Query: 932  VVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQE 991
                                 L+ TL     + +L  +  + + +  +AL++ETR    E
Sbjct: 1155 ---------------------LEDTLDSTATQQELRAKREQEVTVLKKALDEETRS--HE 1191

Query: 992  YVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEK---SRA 1048
              V+E+ +       A  V +L E+LE  +R K   +     L++  A LA E     +A
Sbjct: 1192 AQVQEMRQ-----KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246

Query: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMA 1108
            +++V  K+        +LEA+ Q+LQ      ++ R +  +++  LQ++++ +      A
Sbjct: 1247 KQEVEHKK-------KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA 1299

Query: 1109 EGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKV 1168
            EGK      +K+ KD A+      L+ Q +D     +   R+K  +  K+  LEEE   +
Sbjct: 1300 EGK-----AIKLAKDVAS------LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSL 1348

Query: 1169 VVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEV 1228
              Q+++ E +      E  ++ L ++L + ++K       L+ + S +EAL         
Sbjct: 1349 --QDQLDEEMEAKQNLERHISTLNIQLSDSKKK-------LQDFASTVEALE-------- 1391

Query: 1229 KEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALK-DTKPQVQ 1287
                      +     +KE++ L ++  +K    ++ +    +L++E+  L  D   Q Q
Sbjct: 1392 ----------EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441

Query: 1288 TKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVK 1347
                +++  + ++  Q   E  ++ +K ++E+ +     RE+ ++   +AR  EE    K
Sbjct: 1442 LVSNLEK--KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499

Query: 1348 ERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELE 1407
            E + +   +       L+AE      S D   + + +L    R L+ +  E++ QLEELE
Sbjct: 1500 EELERTNKM-------LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552

Query: 1408 RERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLE 1467
             E QA  +A+  ++   Q L    + + +AR++    ++  LQ   +Q  E+     +LE
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQ---RQLHEY---ETELE 1606

Query: 1468 EEQHRRQL-------LEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLK 1520
            +E+ +R L       LEG+L+ L  +  +  K   +E +     +Q +  D ++E++  +
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGR-EEAIKQLRKLQAQMKDFQRELEDAR 1665

Query: 1521 SSLEEESRSKRELDVEVSRLEARLSELE---FHNSKSSKELDFLREE-----------NH 1566
            +S +E   + +E + +   LEA L +L+       ++ K+ D  +EE            +
Sbjct: 1666 ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRN 1725

Query: 1567 KLQLERQNLQLETRRLQSEI-----NMAATETRDLRNMTVADSGTN----HDSRLWSLER 1617
             LQ E++ L+    +L+ E+     NM A   R  +    A+  +N      S     E 
Sbjct: 1726 ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1785

Query: 1618 ELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEA 1674
                L+R +K+   ++ E++   G+V  K +     L   I  +     +E   ++A
Sbjct: 1786 ARQQLERQNKELRSKLHEME---GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1839



 Score =  116 bits (291), Expect = 2e-25
 Identities = 271/1271 (21%), Positives = 515/1271 (40%), Gaps = 232/1271 (18%)

Query: 206  QARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEA 265
            QA++  L   ++  Q+  NEL  L+Q+                 S+  + +N +   L+A
Sbjct: 855  QAKEDELQKTKERQQKAENELKELEQK----------------HSQLTEEKNLLQEQLQA 898

Query: 266  KEERINKLHSEGDQL---LAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHL--KYME 320
            + E    L++E +++   LAA+      I   MEA   + ++    L  E   +  + ++
Sbjct: 899  ETE----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLD 954

Query: 321  DYHQFHEDVKDAQEL-LRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDK----YE 375
               Q  E+    Q+L L KV ++   K       + + E+L+  +DDQ   L K     E
Sbjct: 955  LEEQLEEEEAARQKLQLEKVTAEAKIK-------KLEDEILV--MDDQNNKLSKERKLLE 1005

Query: 376  DVVQGL-------QKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKN 428
            + +  L       +++ + +  LK + E+ +  + V                      K 
Sbjct: 1006 ERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRL--------------------KK 1045

Query: 429  NGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRY 488
              +S + ++    KL   A  F       E +A    L +Q   ++ + A  +  LQ   
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDF------HEQIA---DLQAQIAELKMQLAKKEEELQAAL 1096

Query: 489  EVLKTENPGDASDLQG-RQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAK 547
              L  E     + L+  R+L   +  +  DLD +               RA ++ AE+ K
Sbjct: 1097 ARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE---------------RAARNKAEKQK 1141

Query: 548  DLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLA 607
                   E L+ E E T  +   +  ++A      T L +   E+T     H  Q+ ++ 
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETR---SHEAQVQEMR 1198

Query: 608  QEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKS 667
            Q+       L + L+Q     A                  LD   Q L     +L  +  
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKAN-----------------LDKNKQTLEKENADLAGELR 1241

Query: 668  LLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQS 727
            +LG+ +Q ++  K+         Q  C D ER  AE   L  + + L+ +VE     L  
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLNE 1298

Query: 728  AKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKI 787
            A+        G    L   V+  S + Q+T  L Q ET+ K   N+  ++   E+E    
Sbjct: 1299 AE--------GKAIKLAKDVASLSSQLQDTQELLQEETRQK--LNVSTKLRQLEEE---- 1344

Query: 788  CANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFT 847
              NS Q Q    D E+EA++     +LE     H+S    +Q   +K K ++ A     +
Sbjct: 1345 -RNSLQDQ---LDEEMEAKQ-----NLER----HIS-TLNIQLSDSKKKLQDFA-----S 1385

Query: 848  EVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDE---ETE 904
             V A+   + +  +   NL +Q  E    ++ L++ +         ++++ELD+   + +
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN--------RLQQELDDLVVDLD 1437

Query: 905  RRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKN 964
             +RQL + ++  Q +   L  +    S    +   +      E+  + L  +LA    + 
Sbjct: 1438 NQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL--SLARALEEA 1495

Query: 965  QLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPD-RAQADEVLQLREELEALRRQ 1023
               +EELE     L+A E E     ++ V K V  +E   RA   ++ +++ +LE L  +
Sbjct: 1496 LEAKEELERTNKMLKA-EMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554

Query: 1024 KGAREAEVLLLQQRVAALAEEKSR-AQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQ 1082
              A E   L L+  + AL  +  R  Q +  + E  + Q   QL  EY+   ED ++Q  
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLH-EYETELEDERKQRA 1613

Query: 1083 L----REKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAAT-EREVSDLTRQY 1137
            L    ++K E +L  L+     L+ + A+   +  +K++ K++      +RE+ D     
Sbjct: 1614 LAAAAKKKLEGDLKDLE-----LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1668

Query: 1138 EDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANL--RLEL 1195
            ++  A A+ ++++   L   +  L+E+ A      K  ++ + +  AE   ++L  R  L
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK-EELAEELASSLSGRNAL 1727

Query: 1196 VEQERKYRG----AEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRL 1251
             +++R+        EE+L   Q  +EA+  R     V++ T++  +   +   E+   + 
Sbjct: 1728 QDEKRRLEARIAQLEEELEEEQGNMEAMSDR-----VRKATQQAEQLSNELATERSTAQK 1782

Query: 1252 REEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQE--DPQTKEEVA 1309
             E      + +ER + E+     E++    +K +     +  +I Q +E  + + +E+ A
Sbjct: 1783 NE---SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1839

Query: 1310 SLRAKLSEEQKK------QVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPG 1363
            + ++ L ++ KK      QV+ ER+ A Q ++ A K    +RVK+               
Sbjct: 1840 ATKS-LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN--ARVKQL-------------- 1882

Query: 1364 LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRL 1423
                            RQ+++   E +R+   R +L+R+L+E     +A     REV  L
Sbjct: 1883 ---------------KRQLEEAEEESQRINANRRKLQRELDEATESNEA---MGREVNAL 1924

Query: 1424 QQRLAALEQEE 1434
            + +L     +E
Sbjct: 1925 KSKLRGPPPQE 1935



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 93/399 (23%), Positives = 160/399 (40%), Gaps = 54/399 (13%)

Query: 23   SNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGR-QPEHRDVTLQKVLDSEKL 81
            +NK L   +E L  + D V KN+ + E   ++   +++E + Q E  +  LQ   D++  
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564

Query: 82   LYV----LEADAAIAKHMKHPQGDMIAEDI-RQLKERVTNLRGKHKQIYRLA-------- 128
            L V    L+         +  Q +     + RQL E  T L  + KQ    A        
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624

Query: 129  -VKEVDPQVNWAALVEE----KLDKLNNQSFGTDLPLVDHQVEEHNIF----HNEVKAIG 179
             +K+++ Q + A    E    +L KL  Q       L D +     IF     NE KA  
Sbjct: 1625 DLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKA-- 1682

Query: 180  PHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQY 239
                    K   ++L    + L AA +AR+Q     ++  +   + L        GR   
Sbjct: 1683 --------KSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL-------SGRNAL 1727

Query: 240  DWSDRNLDYPSRRRQYENFINR---NLEAKEERINKLHSEGDQL---LAAEHPGRNSIEA 293
                R L+  +R  Q E  +     N+EA  +R+ K   + +QL   LA E       E+
Sbjct: 1728 QDEKRRLE--ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNES 1785

Query: 294  HMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGP---- 349
              + +    KE  + L   E  +K          + K AQ L  +V+ +  +K       
Sbjct: 1786 ARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ-LEEQVEQEAREKQAATKSL 1844

Query: 350  DFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQV 388
              KD+   E+LL +++D+ K+ ++Y++  +    R +Q+
Sbjct: 1845 KQKDKKLKEILL-QVEDERKMAEQYKEQAEKGNARVKQL 1882


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score =  161 bits (408), Expect = 5e-39
 Identities = 373/1761 (21%), Positives = 740/1761 (42%), Gaps = 259/1761 (14%)

Query: 16   TVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARL---QEGRQPEHRDVTL 72
            T +T  +S   L E+ E +   +D V  N +DT ++++ + A     QE  + E   +  
Sbjct: 447  TTKTHKLSINLLREIDESVCSESD-VFSNTLDTLSEIEWNPATKLLNQENIESELNSLRA 505

Query: 73   QK---VLDSEKLLYV-------------LEADAAIAKHMKHPQGDMIAEDIRQLKERVTN 116
                 VLD E+L                L+   A+ +  K  Q   +  +I  LK  V  
Sbjct: 506  DYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLV-- 563

Query: 117  LRGKHKQIYRLAVK-EVDPQVNWAALVEEKLDKLNN-------QSFGTDLPLVDHQVEE- 167
               KH ++Y   ++ E+  +V      E+++ KL         ++   DL      +E+ 
Sbjct: 564  ---KHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDP 620

Query: 168  ----HNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCT 223
                  +F  E  A+         + +N EL+ K ++L    +  +  +           
Sbjct: 621  KQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDI----------- 669

Query: 224  NELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAA 283
             +LY    +AK +MQ D                  + + L++    I KL S    L+  
Sbjct: 670  -QLYQSQLEAKKKMQVD------------------LEKELQSAFNEITKLTS----LIDG 706

Query: 284  EHPGRNSIEAHMEAVHADWKEYLNLLICEE----------SHLKYM-EDYHQFHEDVKDA 332
            + P        +E    D ++ LN  + E           S LK +  +  +  ++++D 
Sbjct: 707  KVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDK 766

Query: 333  QELLRKVDSDLNQKYGPDFKDRYQIELLLREL----DDQEKVLDKYEDVVQGLQKRGQQV 388
             E L  + S+ ++ +        +++ LL E+    DD       Y+   Q  Q      
Sbjct: 767  SEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQN----- 821

Query: 389  VPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAV 448
                       K + +    DFE +       Y   L++N   + E+++     L   A 
Sbjct: 822  ----------FKTLHM----DFEQK-------YKMVLEENERMNQEIVN-----LSKEAQ 855

Query: 449  CFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLL 508
             F     D    AL   L  + + +++K     R +Q+R   ++          Q ++ L
Sbjct: 856  KF-----DSSLGALKTELSYKTQELQEKT----REVQERLNEME----------QLKEQL 896

Query: 509  AGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTA 568
               D     ++R++  IT  L+  LE+   V+   +   DLK +  E L+IE ++ +S  
Sbjct: 897  ENRDSTLQTVEREKTLITEKLQQTLEE---VKTLTQEKDDLKQL-QESLQIERDQLKSDI 952

Query: 569  EGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELL 628
                 +       T   LR  +E   +  E +  L     E+V     +E++  ++ +  
Sbjct: 953  HDTVNMNI----DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEF 1008

Query: 629  ATHENHLNQ-DDTVPESSRVL--DSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSST 685
                  +++  D   ++++ L  D K  E+     ++ +      E++Q L++       
Sbjct: 1009 QQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQ 1068

Query: 686  LASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQF 745
            L +  +E+       + E+  LG   + L++Q E  AQ    A        R  D     
Sbjct: 1069 LKTDLKENIEMTIENQEELRLLG---DELKKQQEIVAQEKNHAIKKEGELSRTCDR---- 1121

Query: 746  LVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEA 805
            L  +     +++  L + + +L N +  + E+  +  E++ +    +  +  ++  E E 
Sbjct: 1122 LAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETER 1181

Query: 806  EKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAA-LAAKFTEVYAINRQRLQNLEFAL 864
             +L   L+        ++K  ++     K  E E   L     E+ A   Q  + L+ A 
Sbjct: 1182 LELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAH 1241

Query: 865  NLLRQQPEV------EVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLEN--EVKST 916
              L++  E        V+ +T Q        +   K+++E+    E +  L N  EV  T
Sbjct: 1242 IHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSET 1301

Query: 917  QEEIWTLRNQGPQESVVRKEVLKKVPDPVLE--ESFQQLQ---RTLAEEQHKNQLLQEEL 971
            QE +  L     Q +      L ++    L   E FQ+ Q   ++L +E+   + ++E L
Sbjct: 1302 QETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEAL 1361

Query: 972  EALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAR---E 1028
            E    QL+   +ET    QE   K+   +   + + +E  ++  E+E  + +  A    E
Sbjct: 1362 EVKHDQLKEHIRETLAKIQESQSKQEQSLNM-KEKDNETTKIVSEMEQFKPKDSALLRIE 1420

Query: 1029 AEVLLLQQRVAALAEE-KSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQ 1087
             E+L L +R+    +E KS A+EK    ++ +LQ    L++E  QL+E+ +       + 
Sbjct: 1421 IEMLGLSKRLQESHDEMKSVAKEK---DDLQRLQE--VLQSESDQLKENIKEIVAKHLET 1475

Query: 1088 EEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARAS 1147
            EEEL      LK  E+E  + E ++ + E          E E+S + +Q E       A 
Sbjct: 1476 EEELKVAHCCLK--EQEETINELRVNLSE---------KETEISTIQKQLE-------AI 1517

Query: 1148 QREKTELLRKIWALEEE-NAKVV--VQEKVREI--VRPDPKA-ESEVANLRLELVEQERK 1201
              +    +++I+  EE+ N K +  VQEKV E+   +   KA +S + ++  +++E   +
Sbjct: 1518 NDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNR 1577

Query: 1202 YRGAEEQLRSYQSELEALRR--RGPQVE---VKEVTKEVIKYKTDPEMEKELQRLREEIV 1256
             + ++E+++    E E ++R     Q+E   +KE TKE++  K     EKE Q L+   V
Sbjct: 1578 LQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVA-KMKESQEKEYQFLKMTAV 1636

Query: 1257 DKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEV-VQEILQFQEDPQTKEEVASLRAKL 1315
            ++T+  + C++E   LK++ +  K     ++T+ + + +IL   E+ +    V   R  L
Sbjct: 1637 NETQE-KMCEIE--HLKEQFETQKLNLENIETENIRLTQILH--ENLEEMRSVTKERDDL 1691

Query: 1316 -SEEQKKQVDLERERASQEEQIAR---KEEELSRVKERVVQ-QEVVRYEEEPGLRAEASA 1370
             S E+  +V+ ++ + +  E I R   K+EEL  V   + + QE +  ++  G+ +E + 
Sbjct: 1692 RSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETI--DKLRGIVSEKTN 1749

Query: 1371 FAESIDVELRQI-DKLRAELRRLQRR----RTELERQLEELERERQARREAEREVQRLQQ 1425
               ++  +L    D L+A+  ++Q         L+ Q E +++ R    E   ++  +Q+
Sbjct: 1750 EISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQK 1809

Query: 1426 RL----AALEQ--EEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGE 1479
             L    A L++  +E +A E    T K  + +  ++  E   L+ Q++++      LE E
Sbjct: 1810 DLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIE 1869

Query: 1480 LETLRRKLAA-LE--KAEVKEKVVL---SESVQVEKGDTEQEIQRLKS---SLEEESRSK 1530
               L +KL   LE  K+ +KE+  L    E++++E+   ++ +Q  K+    +++E ++ 
Sbjct: 1870 NLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTA 1929

Query: 1531 RELDVE----VSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEI 1586
            R L  E    V +L  ++SE     S   K+LD  ++E  K   E Q  +L+  R++ ++
Sbjct: 1930 RMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDV 1989

Query: 1587 NMAATETRDL---------RNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQ 1637
            NM+  +  ++         +N+++     ++      L   L++++ ++K++    DEL+
Sbjct: 1990 NMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKER----DELR 2045

Query: 1638 KRLGSVAVKREQRENHLRRSI 1658
            +   S+ ++R+Q    LR  I
Sbjct: 2046 RIKESLKMERDQFIATLREMI 2066



 Score =  130 bits (327), Expect = 1e-29
 Identities = 219/1047 (20%), Positives = 436/1047 (41%), Gaps = 179/1047 (17%)

Query: 758  DSLSQME----TKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYEL---------- 803
            D+LS++E    TKL NQ+N+  E+ S   +   +  + +Q +   ++ EL          
Sbjct: 477  DTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDE 536

Query: 804  ------------------EAEKLRSLL--------DLENGRSSHVSKRARLQSPATKVKE 837
                              E   L++L+        DLEN  SS V      +    K++E
Sbjct: 537  FEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQE 596

Query: 838  EEAALAAKFTEVYAINRQRLQN----LEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAW 893
                          I+ Q+L+N    L ++L  +    +++ T    +    D+  E A+
Sbjct: 597  -------------YIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAF 643

Query: 894  KIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQL 953
             +R E  E  E+ ++L    K  + +I   ++Q   +  ++ ++ K++     E    +L
Sbjct: 644  -LRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNE--ITKL 700

Query: 954  QRTLAEEQHKNQLLQEELEA----LQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQ--A 1007
               +  +  K+ L   ELE     LQ +L    +E     +E ++   L+  P   +   
Sbjct: 701  TSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR 760

Query: 1008 DEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLE 1067
             E+    EEL  +  +K    +EV+  + RV  L EE  + ++ +   +     N    +
Sbjct: 761  KEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQ----SNYKSTD 816

Query: 1068 AEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKI-TVKEVLKVEKDAAT 1126
             E+Q  +  H   +Q  +   EE   +  ++  L KE    +  +  +K  L  +     
Sbjct: 817  QEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQ 876

Query: 1127 ER---------EVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEK---- 1173
            E+         E+  L  Q E+  +  +  +REKT +  K+    EE  K + QEK    
Sbjct: 877  EKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEE-VKTLTQEKDDLK 935

Query: 1174 ----VREIVRPDPKAE-SEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEV 1228
                  +I R   K++  +  N+ ++  EQ    R A E L+ +Q  +  L+        
Sbjct: 936  QLQESLQIERDQLKSDIHDTVNMNIDTQEQ---LRNALESLKQHQETINTLK-------- 984

Query: 1229 KEVTKEVIKYKTDPEMEKELQRLREEIVDK-TRLIERCDLEIYQLKKEIQALKDTKPQVQ 1287
             ++++EV +   +  ME+     ++E   K   + ++ DLE    +     +KD +   Q
Sbjct: 985  SKISEEVSR---NLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQ 1041

Query: 1288 TKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVK 1347
             +++   I +  E  Q  E V + + +L  + K+ +++  E    +E++    +EL + +
Sbjct: 1042 QRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIE---NQEELRLLGDELKKQQ 1098

Query: 1348 ERVVQQEVVRYEEEPGLRAEASAFA---ESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
            E V Q++    ++E  L       A   E +  + +Q+ + + +L  +Q   +E+++++ 
Sbjct: 1099 EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN 1158

Query: 1405 ELERERQARREAEREVQRLQQRLAALEQ---EEAEAREKVTHTQKVV--LQQDPQQAREH 1459
            E+E  +   +  E  ++ ++     L Q   E  E  + +T  +KV+  LQ+  +  R+H
Sbjct: 1159 EIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDH 1218

Query: 1460 --------ALLRLQLEEEQ-----HRRQLLEGELETLRRKLAA----------LEKAEVK 1496
                        LQ +EE      H ++  E  ++ LRR ++           LEK+  K
Sbjct: 1219 LRGYIREIEATGLQTKEELKIAHIHLKEHQE-TIDELRRSVSEKTAQIINTQDLEKSHTK 1277

Query: 1497 ---EKVVLSESVQV-----EKGDTEQEIQRL----KSSLEEESRSKRELDVEVSRLEARL 1544
               E  VL E  ++     E  +T++ +  L    + S  ++S +   +++E  RL  + 
Sbjct: 1278 LQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKF 1337

Query: 1545 SELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADS 1604
             E +      +KE D L+     L+++   L+   R   ++I  + ++     NM   D+
Sbjct: 1338 QESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDN 1397

Query: 1605 GTN-----------HDSRLWSLEREL-----------DDLKRLSKDKDLEIDELQKRLGS 1642
             T             DS L  +E E+           D++K ++K+KD ++  LQ+ L S
Sbjct: 1398 ETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKD-DLQRLQEVLQS 1456

Query: 1643 VAVKREQRENHLRRSIVVIHPDTGREL 1669
               + +Q + ++ + IV  H +T  EL
Sbjct: 1457 ---ESDQLKENI-KEIVAKHLETEEEL 1479



 Score =  121 bits (303), Expect = 7e-27
 Identities = 321/1691 (18%), Positives = 685/1691 (40%), Gaps = 281/1691 (16%)

Query: 17   VQTRSISNKELSELIEQLQKNADQVEKNIVDT---EAKMQSDLARLQEGRQPEHRDVTLQ 73
            V+T +    +L +L E LQ   DQ++ +I DT       Q  L    E  +     +   
Sbjct: 924  VKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL 983

Query: 74   KVLDSEKLLYVLEADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKE-- 131
            K   SE++   L  +    +     Q  M+  D +Q      +L  K+ Q     VK+  
Sbjct: 984  KSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQ------DLEAKNTQTLTADVKDNE 1037

Query: 132  -VDPQVNWAALVEEKLDK--------LNNQSFGTDLP-----LVDHQVEEHNIFHNEVKA 177
             ++ Q    +L++EK +            +   TDL       +++Q EE  +  +E+K 
Sbjct: 1038 IIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQ-EELRLLGDELKK 1096

Query: 178  IGPHLA--------KDGDKEQNSELRAKYQKLLAAS----QARQQHLSSLQDYM---QRC 222
                +A        K+G+  +  +  A+ ++ L       Q +QQ L ++Q+ M   Q+ 
Sbjct: 1097 QQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKK 1156

Query: 223  TNELYWLDQQAKGR---MQYDWSDR-------NLDYP-----SRRRQYENFINRNLEAKE 267
             NE+  L  + K +   +++  ++R       N +Y      ++ R+    + ++ E + 
Sbjct: 1157 INEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETER 1216

Query: 268  ER----INKLHSEGDQLLAAEHPGRNSIEAHME-------AVHADWKEYLNLLICEESHL 316
            +     I ++ + G Q           ++ H E       +V     + +N    E+SH 
Sbjct: 1217 DHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT 1276

Query: 317  KYMEDYHQFHE---------DVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQ 367
            K  E+    HE         +V + QE + +++    Q    D     +IE+    L+++
Sbjct: 1277 KLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEK 1336

Query: 368  EKVLDKYEDVVQGLQKRGQQVVPLKYRRET---PLKPIPVEALCDFEGEQGLISRGYSYT 424
                 + ++ ++ L K    +  +K   E     LK    E L   +  Q    +  S  
Sbjct: 1337 ---FQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQS--KQEQSLN 1391

Query: 425  LQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTL 484
            +++ + E+ +++                 P D   L            +  +  G  + L
Sbjct: 1392 MKEKDNETTKIVSEMEQ----------FKPKDSALL-----------RIEIEMLGLSKRL 1430

Query: 485  QQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAE 544
            Q+ ++ +K+    +  DLQ  Q     + + S+ D+ ++ I  I+   LE    ++ +  
Sbjct: 1431 QESHDEMKSV-AKEKDDLQRLQ-----EVLQSESDQLKENIKEIVAKHLETEEELKVAHC 1484

Query: 545  RAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHL-LQL 603
              K+ +   NEL     EK    +  +  ++A+        L+ ++++   K E   ++ 
Sbjct: 1485 CLKEQEETINELRVNLSEKETEISTIQKQLEAI-----NDKLQNKIQEIYEKEEQFNIKQ 1539

Query: 604  LDLAQEKVDVANRLEKSLQQSWELLATHENHL----NQDDTVPESSRVLDSKGQELAAMA 659
            +   QEKV+   + ++  +     L + E+ +    N+     E  +++  + +E+  + 
Sbjct: 1540 ISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQ 1599

Query: 660  CELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQE--AEVHKLGQRFNNLRQQ 717
              LQ ++  L E  + + A  + S     +F +     E QE   E+  L ++F   +  
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLN 1659

Query: 718  VER-RAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQ----KN 772
            +E    ++++  +  +E+        L+ + S+     +E D L  +E  LK +    K 
Sbjct: 1660 LENIETENIRLTQILHEN--------LEEMRSV----TKERDDLRSVEETLKVERDQLKE 1707

Query: 773  LLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPA 832
             L E  +R+ E Q+     +     +K+++   +KLR ++  +    S++ K     + A
Sbjct: 1708 NLRETITRDLEKQE---ELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDA 1764

Query: 833  TKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEA 892
             K ++                             L+ Q E+ + H  L+  +     E  
Sbjct: 1765 LKAQD-----------------------------LKIQEELRIAHMHLKEQQ-----ETI 1790

Query: 893  WKIRKELDEETER----RRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEE 948
             K+R  + E+T++    ++ LEN     QE+I  L+    Q   ++K+V           
Sbjct: 1791 DKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDV----------- 1839

Query: 949  SFQQLQRTLAE-EQHKNQLLQEELEALQLQLRALE--QETRDGGQEYVVKEVLRIEPDRA 1005
               + Q+ ++E EQ K Q+  + L   +L++  L   Q+  +  +E  +K V++   +  
Sbjct: 1840 --NETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEE--MKSVMKERDNLR 1895

Query: 1006 QADEVLQL-REELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDP 1064
            + +E L+L R++L+   ++  AR+ E+    +    L++E     +K+ EK   K     
Sbjct: 1896 RVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQIS 1955

Query: 1065 QLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDA 1124
             ++ +  + +++ Q+  +++E Q++EL  L     R++++  M+  KI   E LK + +A
Sbjct: 1956 DIQKDLDKSKDELQK--KIQELQKKELQLL-----RVKEDVNMSHKKINEMEQLKKQFEA 2008

Query: 1125 ------ATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIV 1178
                  +   +   LT++  +   + R   +E+ EL R   +L+ E  + +    +RE++
Sbjct: 2009 QNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIA--TLREMI 2066

Query: 1179 RPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVE--VKEVTKEVI 1236
              D +        RL    Q+       E LR   S ++ L +R  +++   + + +  +
Sbjct: 2067 ARDRQNHQVKPEKRLLSDGQQH----LTESLREKCSRIKELLKRYSEMDDHYECLNRLSL 2122

Query: 1237 KYKTDPEMEKELQR----------LREEIVDKT-RLIERCDLEIYQLKKEIQALKDTKPQ 1285
              + + E +KEL            L+ + ++K     +RC +E +++ K++         
Sbjct: 2123 DLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKL--------- 2173

Query: 1286 VQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSR 1345
               K V+  + + +E+    E +        +E +KQ +L  +    ++       EL  
Sbjct: 2174 ---KYVLSYVTKIKEEQH--ESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRD 2228

Query: 1346 VKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEE 1405
            +K   + Q +  + EE  L+  + +   SI  E +Q+   R E+ +           +E+
Sbjct: 2229 LK---LNQNMDLHIEEI-LKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEK 2284

Query: 1406 LERERQARREAEREVQR-LQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRL 1464
            L+   Q   +   +V      R+ A+  E  E  E+     K   +QD +  +E      
Sbjct: 2285 LKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISK-EWEQDLKSLKE------ 2337

Query: 1465 QLEEEQHRRQLLEGELETLRRKLAALEKA-----EVKEKVVLSESVQVEKGDTEQEIQRL 1519
                   + + L    +TL+  LA+  +      + K   V S + Q+    T ++I+ L
Sbjct: 2338 -------KNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQL----TTEKIREL 2386

Query: 1520 KSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLET 1579
            ++SL E   S    + ++ +++    ELE  N   +K    + E N  L+  ++ +Q+  
Sbjct: 2387 ENSLHEAKESAMHKESKIIKMQ---KELEVTNDIIAKLQAKVHESNKCLEKTKETIQV-- 2441

Query: 1580 RRLQSEINMAA 1590
              LQ ++ + A
Sbjct: 2442 --LQDKVALGA 2450



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 130/623 (20%), Positives = 274/623 (43%), Gaps = 108/623 (17%)

Query: 1128 REVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQ-EKVREIVRPDPKAES 1186
            +E+ DL +Q E+ + + RA   EK +L +    LEE++    VQ EK+  + R    + S
Sbjct: 350  KEIMDLKKQLEEVSLETRAQAMEKDQLAQ---LLEEKDLLQKVQNEKIENLTRMLVTSSS 406

Query: 1187 EVANLRLELVEQER-----------KYRGAEEQL--------RSYQSELEALRRRGPQV- 1226
                  L+   + R           K     +Q         ++++  +  LR     V 
Sbjct: 407  LTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVC 466

Query: 1227 EVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCD-----LEIYQL---KKEIQA 1278
               +V    +   ++ E     + L +E ++      R D     L+  QL   K+E++ 
Sbjct: 467  SESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMEL 526

Query: 1279 LKDTKPQVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIAR 1338
                K  +   E ++   +  ++ Q   E+++L+  +   +    DLE E +S+ E +  
Sbjct: 527  KLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLRE 586

Query: 1339 KEEELSRVKERVVQQEVVRYE----------EEPGLRAEASAFAESIDVEL-RQIDKLRA 1387
            KE+++ +++E +  Q++   +          E+P    +    AE++ ++  R+   LR+
Sbjct: 587  KEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRS 646

Query: 1388 ELRRLQRRRTELERQLEELERE---RQARREAEREVQRLQQRLAALEQEEAEAREKVTHT 1444
            E   L+ +  EL    +++E +    Q++ EA++++Q        LE+E   A  ++T  
Sbjct: 647  ENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQ------VDLEKELQSAFNEITKL 700

Query: 1445 QKVV-----------LQQDPQQAREHALLRLQLEEEQHRRQ--LLEGELETLRRKLAALE 1491
              ++           L+ + +       L  ++EE +  R+  +L  EL++L  ++  L 
Sbjct: 701  TSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR 760

Query: 1492 KAEVKEKVVLSESVQVEKGDTEQEI----QRLKSSLEEESRSKRELDVEVSRLEARLSEL 1547
            K E+++K      +  EK     E+     R++  LEE  ++K +L    S  ++  ++ 
Sbjct: 761  K-EIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKS--TDQ 817

Query: 1548 EFHNSKS-----SKELDFLREENHKLQLERQNLQLETRRLQSEINMAATE----TRDLRN 1598
            EF N K+      ++   + EEN ++  E  NL  E ++  S +    TE    T++L+ 
Sbjct: 818  EFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQE 877

Query: 1599 MT------------VADSGTNHDSRLWSLERE-----------LDDLKRLSKDKDLEIDE 1635
             T            + +   N DS L ++ERE           L+++K L+++KD ++ +
Sbjct: 878  KTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD-DLKQ 936

Query: 1636 LQKRLGSVAVKREQRENHLRRSI 1658
            LQ+   S+ ++R+Q ++ +  ++
Sbjct: 937  LQE---SLQIERDQLKSDIHDTV 956



 Score = 67.0 bits (162), Expect = 2e-10
 Identities = 232/1378 (16%), Positives = 545/1378 (39%), Gaps = 186/1378 (13%)

Query: 27   LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86
            L  + E L+   DQ++++I +T AK+Q   ++ ++    + +D    K++   ++     
Sbjct: 1354 LKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVS--EMEQFKP 1411

Query: 87   ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEKL 146
             D+A+ +         I  ++  L +R+     + K +     KE D       +++ + 
Sbjct: 1412 KDSALLR---------IEIEMLGLSKRLQESHDEMKSV----AKEKDDLQRLQEVLQSES 1458

Query: 147  DKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQ 206
            D+L           +   V +H     E+K    H      +E  +ELR    +      
Sbjct: 1459 DQLKEN--------IKEIVAKHLETEEELKVA--HCCLKEQEETINELRVNLSEKETEIS 1508

Query: 207  ARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAK 266
              Q+ L ++ D +Q    E+Y  ++Q            N+   S  ++  N + +  E +
Sbjct: 1509 TIQKQLEAINDKLQNKIQEIYEKEEQF-----------NIKQISEVQEKVNELKQFKEHR 1557

Query: 267  EERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFH 326
            + + + L S   ++L   +  + S            +E + ++I E+  +K +++  Q  
Sbjct: 1558 KAKDSALQSIESKMLELTNRLQES------------QEEIQIMIKEKEEMKRVQEALQIE 1605

Query: 327  EDV--KDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKR 384
             D   ++ +E++ K+     ++Y   F     +     ++ + E + +++E      QK 
Sbjct: 1606 RDQLKENTKEIVAKMKESQEKEY--QFLKMTAVNETQEKMCEIEHLKEQFET-----QKL 1658

Query: 385  GQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWE-LMDSAGNKL 443
              + +  +  R T +    +E +     E+  + R    TL+    +  E L ++    L
Sbjct: 1659 NLENIETENIRLTQILHENLEEMRSVTKERDDL-RSVEETLKVERDQLKENLRETITRDL 1717

Query: 444  IAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQ 503
                   ++     E     D L         + +  ++ L+   + LK ++     +L+
Sbjct: 1718 EKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELR 1777

Query: 504  G-----RQLLAGLDKVASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLR 558
                  ++    +DK+   +  +   ++  ++  LE   A     E+ ++LK   ++L+ 
Sbjct: 1778 IAHMHLKEQQETIDKLRGIVSEKTDKLSN-MQKDLENSNAKLQ--EKIQELKANEHQLIT 1834

Query: 559  IEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLE 618
            ++ +   +  +     Q          L+ +++D +      L L  L  E +++A +L 
Sbjct: 1835 LKKDVNETQKKVSEMEQ----------LKKQIKDQS------LTLSKLEIENLNLAQKLH 1878

Query: 619  KSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQA 678
            ++L++   ++   +N    ++T+      L    QE  A   E+Q          Q L+ 
Sbjct: 1879 ENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQ----------QELKT 1928

Query: 679  AKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAY----EH 734
            A+  S        +    +  +  ++  + +  +  + +++++ Q LQ  +       E 
Sbjct: 1929 ARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKED 1988

Query: 735  FHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQY 794
             +  H  + +       +E Q   +LS    ++ N + L  ++    +E++ +     + 
Sbjct: 1989 VNMSHKKINEMEQLKKQFEAQ---NLSMQSVRMDNFQ-LTKKLHESLEEIRIVAKERDEL 2044

Query: 795  QQAVKDYELEAEKLRSLLD--LENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAI 852
            ++  +  ++E ++  + L   +   R +H            +VK E+  L+     +   
Sbjct: 2045 RRIKESLKMERDQFIATLREMIARDRQNH------------QVKPEKRLLSDGQQHLTES 2092

Query: 853  NRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENE 912
             R++   ++    LL++  E++  +E L  NR    +E+  + +KEL    +    L   
Sbjct: 2093 LREKCSRIK---ELLKRYSEMDDHYECL--NRLSLDLEKEIEFQKELSMRVKANLSLPYL 2147

Query: 913  VKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLE------ESFQQLQRTLAEEQHKNQL 966
                 E+++T   +   E     + LK V   V +      ES  + +    +E  K + 
Sbjct: 2148 QTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKE 2207

Query: 967  LQEELEALQLQLRALEQETRD----GGQEYVVKEVLRIEPDRAQADEVLQLREELEALRR 1022
            L  +++ LQ       +E RD       +  ++E+L+   D +++ E   ++ E + +  
Sbjct: 2208 LLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILK---DFSES-EFPSIKTEFQQVLS 2263

Query: 1023 QKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQN--DPQLEAEYQQLQEDHQRQ 1080
             +  +E    L +        EK +   +     + ++ N  + ++ A   +  E  +R 
Sbjct: 2264 NR--KEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERS 2321

Query: 1081 DQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDE 1140
              + ++ E++L  L++K ++L K         T+K  L      A+  +V+  T+  ++ 
Sbjct: 2322 ATISKEWEQDLKSLKEKNEKLFKNYQ------TLKTSL------ASGAQVNPTTQDNKNP 2369

Query: 1141 AAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESE---VANLRLELVE 1197
               +RA+Q   TE +R++     E AK     K  +I++   + E     +A L+ ++ E
Sbjct: 2370 HVTSRATQLT-TEKIRELENSLHE-AKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHE 2427

Query: 1198 QERKYRGAEEQL-----------RSYQSELEALRRRGPQVEV------KEVTKEVIKYKT 1240
              +     +E +           + Y+ E+E L+ +  ++++      KE  KE+   K 
Sbjct: 2428 SNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKA 2487

Query: 1241 DPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVV----QEIL 1296
              E +KE+ RL  E + +++          Q +      + T PQ   K +       I+
Sbjct: 2488 TVEYQKEVIRLLRENLRRSQ----------QAQDTSVISEHTDPQPSNKPLTCGGGSGIV 2537

Query: 1297 QFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQE 1354
            Q  +    K E   L  ++S+ +++   L +++            E+   KER +++E
Sbjct: 2538 QNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKRE 2595



 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 57/286 (19%), Positives = 121/286 (42%), Gaps = 35/286 (12%)

Query: 1379 LRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAEAR 1438
            + ++    A L+R ++   +L++QLEE+  E +A+   + ++ +L +    L++ + E  
Sbjct: 335  VNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKI 394

Query: 1439 EKVTH----TQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAE 1494
            E +T     +  + LQQ+ +  R+                         RR    L K  
Sbjct: 395  ENLTRMLVTSSSLTLQQELKAKRK-------------------------RRVTWCLGKIN 429

Query: 1495 VKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSK-RELDVEVSRLEARLSELEFHNSK 1553
              +    ++   +    T +  +   + L E   S   E DV  + L+  LSE+E++ + 
Sbjct: 430  KMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDT-LSEIEWNPAT 488

Query: 1554 SSKELDFLREENHKLQLERQNLQLETRRLQS---EINMAATETRDLRNMTVADSGTNHDS 1610
                 + +  E + L+ +  NL L+  +L++   E+ +   E  DL      +  T  D 
Sbjct: 489  KLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQ 548

Query: 1611 RLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRENHLRR 1656
             +  L  E+ +LK L K  ++   +L+  L S      ++E+ +++
Sbjct: 549  EM-QLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKK 593


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  160 bits (405), Expect = 1e-38
 Identities = 249/1173 (21%), Positives = 504/1173 (42%), Gaps = 146/1173 (12%)

Query: 529  LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRT 588
            ++P L+  R  Q+   +AKD      ELL+++ ++T+   E E   +           + 
Sbjct: 841  VKPLLQVTR--QEEELQAKD-----EELLKVKEKQTKVEGELEEMERKH---------QQ 884

Query: 589  RVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVL 648
             +E+ N   E L    +L  E  ++  RL    Q+  E+L   E+ + +++   E +++L
Sbjct: 885  LLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEE---ERNQIL 941

Query: 649  DSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLG 708
             ++ +++ A   +L+ Q        Q LQ  K  +     + +E    LE Q ++  K  
Sbjct: 942  QNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEK 1001

Query: 709  QRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLK 768
            +   +   +   +    +             + ++  L      E +    L + + KL 
Sbjct: 1002 KLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLD 1061

Query: 769  NQK-NLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRAR 827
             +  +L D+IA  + ++ ++     + Q A K+ EL+    R   D E    ++  K  R
Sbjct: 1062 GETTDLQDQIAELQAQIDEL-----KLQLAKKEEELQGALARG--DDETLHKNNALKVVR 1114

Query: 828  -LQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPD 886
             LQ+   +++E+  +  A   +     R   + LE     L    +     + L+  R  
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKRE- 1173

Query: 887  SGVEEAWKIRKELDEETERRR-QLENEVKSTQEEIWTLRNQGPQESVVRKEVLK-----K 940
               +E  +++K L+EET+    Q+++  +     +  L  Q  Q    +  + K     +
Sbjct: 1174 ---QEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLE 1230

Query: 941  VPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRI 1000
              +  L    + LQ+  AE +HK +        L  Q++ L  +  +G +       LR+
Sbjct: 1231 TDNKELACEVKVLQQVKAESEHKRK-------KLDAQVQELHAKVSEGDR-------LRV 1276

Query: 1001 EPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKL 1060
            E     A++  +L+ EL+ +       E + +   +  A+L  +    QE + E+   KL
Sbjct: 1277 E----LAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKL 1332

Query: 1061 QNDP---QLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEV 1117
                   QLE E   LQE  + +++ R+  E+++  LQ +L   +K+  + +   T++ +
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKK--VDDDLGTIESL 1390

Query: 1118 LKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREI 1177
             + +K    + E   L+++ E++A      ++ K  L +++  L       V  +  R++
Sbjct: 1391 EEAKKKLLKDAEA--LSQRLEEKALAYDKLEKTKNRLQQELDDL------TVDLDHQRQV 1442

Query: 1178 VRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIK 1237
                 K + +   L  E  E+    R AEE+ R+   E EA  +    + +    +E ++
Sbjct: 1443 ASNLEKKQKKFDQLLAE--EKSISARYAEERDRA---EAEAREKETKALSLARALEEALE 1497

Query: 1238 YKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTK-EVVQEIL 1296
             K   E E++ ++LR ++ D     +     +++L+K  +AL+    +++T+ E +++ L
Sbjct: 1498 AKE--EFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555

Query: 1297 QFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVV 1356
            Q  ED + + EV          Q  +   ER+  +++EQ     EE  R+  + V++   
Sbjct: 1556 QATEDAKLRLEV--------NMQAMKAQFERDLQTRDEQ----NEEKKRLLIKQVRELEA 1603

Query: 1357 RYEEEPGLRAEASAFAESIDVELRQI-----------DKLRAELRRLQRRRTELERQLEE 1405
              E+E   RA A A  + ++++L+ +           D++  +LR+LQ +  + +R+LEE
Sbjct: 1604 ELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEE 1663

Query: 1406 LERER-----------QARREAEREVQRLQQRLAA-------LEQEEAEAREKVTHT--- 1444
                R           +  +  E E+ +LQ+ LA+        EQE  E  +++T++   
Sbjct: 1664 ARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASG 1723

Query: 1445 QKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEG-------ELETLRRKLAALEKAEVKE 1497
            +  +L +  +     A L  +LEEEQ   +LL         +++TL  +LAA   A  K 
Sbjct: 1724 KSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQK- 1782

Query: 1498 KVVLSESVQVEKGDTEQEIQRLKSSLEE-ESRSKRELDVEVSRLEARLSELEFHNSKSSK 1556
                S++ + +    E++ + LK+ L+E E   K +    +S LEA++ +LE    + +K
Sbjct: 1783 ----SDNARQQ---LERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAK 1835

Query: 1557 EL----DFLREENHKL-----QLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTN 1607
            E       +R    KL     Q+E +    +  + Q E   A  +    +     +  T 
Sbjct: 1836 ERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATR 1895

Query: 1608 HDSRLWSLERELDDLKRLSKDKDLEIDELQKRL 1640
             ++    L+RELDD    ++    E+  L+ RL
Sbjct: 1896 ANASRRKLQRELDDATEANEGLSREVSTLKNRL 1928



 Score =  120 bits (300), Expect = 2e-26
 Identities = 232/1168 (19%), Positives = 476/1168 (40%), Gaps = 168/1168 (14%)

Query: 190  QNSELRAKYQKLLAASQARQQ---HLSSLQDYMQRCTNELYWLDQQAKGRMQY--DWSDR 244
            Q  EL+AK ++LL   + + +    L  ++   Q+   E   L +Q +   +   +  + 
Sbjct: 850  QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909

Query: 245  NLDYPSRRRQYENFIN---RNLEAKEERINKLHSEGDQLLA----------AEHPGRNSI 291
                 +++++ E  ++     +E +EER   L +E  ++ A           E   R  +
Sbjct: 910  RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKL 969

Query: 292  EAHMEAVHADWKEYLN-LLICEESHLKYMEDYHQFHEDVKDAQELLRKVD---------- 340
            +       A  K+    +L+ E+ + K++++     + + +    L + +          
Sbjct: 970  QLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIR 1029

Query: 341  -------SDLNQKYGPDFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKY 393
                   SDL ++   + K R ++E   R+LD +   L   +D +  LQ +  ++     
Sbjct: 1030 NKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDL---QDQIAELQAQIDELKLQLA 1086

Query: 394  RRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIP 453
            ++E  L              QG ++RG   TL KNN                     V+ 
Sbjct: 1087 KKEEEL--------------QGALARGDDETLHKNNALK------------------VVR 1114

Query: 454  PTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDK 513
                +   L +   S+ ++ R KA   KR L +  E LKTE          +Q L    K
Sbjct: 1115 ELQAQIAELQEDFESE-KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELR--TK 1171

Query: 514  VASDLDRQEKAITGILRPPLEQGRAVQDSAER-AKDLKNITNELLRIEPEKTRSTAEGEA 572
               ++   +KA+    +    Q   +QD  +R A  L+ ++ +L     +  R  A  E 
Sbjct: 1172 REQEVAELKKALEEETKNHEAQ---IQDMRQRHATALEELSEQL----EQAKRFKANLEK 1224

Query: 573  FIQALPGSGTTPLLRTRV-EDTNRKYEHLLQLLDLAQE----KVDVANRLEKSLQQSWEL 627
              Q L           +V +    + EH  + LD   +    KV   +RL   L +    
Sbjct: 1225 NKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASK 1284

Query: 628  LATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLA 687
            L   +N L+   T+ E +   + KG + A  A  L++Q   L + ++ LQ   +    L+
Sbjct: 1285 L---QNELDNVSTLLEEA---EKKGIKFAKDAASLESQ---LQDTQELLQEETRQKLNLS 1335

Query: 688  SRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLV 747
            SR ++    LE ++  + +  +     R+ +E++  +LQS  A  +         ++ L 
Sbjct: 1336 SRIRQ----LEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLE 1391

Query: 748  SIPSYEPQETDSLSQMETKLKNQKNLLDEIASR-EQEVQKICANSQQYQQAVKDYELEAE 806
                   ++ ++LSQ   +     + L++  +R +QE+  +  +    +Q   + E + +
Sbjct: 1392 EAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQK 1451

Query: 807  KLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNL 866
            K   LL  E   S+  ++         + KE +A   A+  E         + LE     
Sbjct: 1452 KFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE---------EALEAKEEF 1502

Query: 867  LRQQPEVEVTHETLQRNRPDSG--VEEAWKIRKELDEETERRR----QLENEVKSTQE-- 918
             RQ  ++    E L  ++ D G  V E  K ++ L+++ E  R    +LE+E+++T++  
Sbjct: 1503 ERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAK 1562

Query: 919  -----EIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEA 973
                  +  ++ Q  ++   R E   +    +L +  ++L+  L +E+ +  L     + 
Sbjct: 1563 LRLEVNMQAMKAQFERDLQTRDE-QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK 1621

Query: 974  LQLQLRALEQ--ETRDGGQEYVVKEVLR-----------IEPDRAQADEVLQLREELEAL 1020
            +++ L+ LE   E  +  ++ V+K++ +           +E  RA  DE+    +E E  
Sbjct: 1622 MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESE-- 1679

Query: 1021 RRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQ 1080
             ++  + EAE+L LQ+ +A+    +  A+++  E       +     A   + +    R 
Sbjct: 1680 -KKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738

Query: 1081 DQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDE 1140
             QL E+ EEE S ++    R  K     +   T+   L  E+ AA + + +    + +++
Sbjct: 1739 AQLEEELEEEQSNMELLNDRFRKTTLQVD---TLNAELAAERSAAQKSDNARQQLERQNK 1795

Query: 1141 AAKARASQRE---KTELLRKIWALE------EENAKVVVQEK--VREIVRPDPKAESEVA 1189
              KA+  + E   K++    I ALE      EE  +   +E+    ++VR   + E ++ 
Sbjct: 1796 ELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVR---RTEKKLK 1852

Query: 1190 NLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQ 1249
             + +++ ++ R     +EQ+    + ++ L+R+  + E +E T+               +
Sbjct: 1853 EIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE-EEATR----------ANASRR 1901

Query: 1250 RLREEIVDKTRLIERCDLEIYQLKKEIQ 1277
            +L+ E+ D T   E    E+  LK  ++
Sbjct: 1902 KLQRELDDATEANEGLSREVSTLKNRLR 1929



 Score = 78.2 bits (191), Expect = 7e-14
 Identities = 96/425 (22%), Positives = 181/425 (42%), Gaps = 74/425 (17%)

Query: 1287 QTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRV 1346
            + K ++Q   Q +E     EE+  ++       +KQ  +E E     E++ RK ++L   
Sbjct: 840  KVKPLLQVTRQEEELQAKDEELLKVK-------EKQTKVEGEL----EEMERKHQQLLEE 888

Query: 1347 KERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEEL 1406
            K  + +Q          L+AE   FAE+ ++  R    L A+ + L+    +LE ++EE 
Sbjct: 889  KNILAEQ----------LQAETELFAEAEEMRAR----LAAKKQELEEILHDLESRVEEE 934

Query: 1407 ERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQL 1466
            E   Q  +  ++++Q   Q L     EE  AR+K+   +KV  +   ++  E  LL   L
Sbjct: 935  EERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKL-QLEKVTAEAKIKKMEEEILL---L 990

Query: 1467 EEEQHR----RQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSS 1522
            E++  +    ++L+E  +     +LA  E+ + K    +    +V   D E+ +++ + +
Sbjct: 991  EDQNSKFIKEKKLMEDRIAECSSQLAE-EEEKAKNLAKIRNKQEVMISDLEERLKKEEKT 1049

Query: 1523 LEEESRSKRELDVE-------VSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNL 1575
             +E  ++KR+LD E       ++ L+A++ EL+   +K  +EL           L + N 
Sbjct: 1050 RQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNA 1109

Query: 1576 QLETRRLQSEI--------------NMAATETRDLRNMTVADSGTNHDSRLWSLERELDD 1621
                R LQ++I              N A  + RDL               L +L+ EL+D
Sbjct: 1110 LKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL------------SEELEALKTELED 1157

Query: 1622 L-------KRLSKDKDLEIDELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRELSPEEA 1674
                    + L   ++ E+ EL+K L       E +   +R+       +   +L   + 
Sbjct: 1158 TLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKR 1217

Query: 1675 HRAGL 1679
             +A L
Sbjct: 1218 FKANL 1222



 Score = 73.6 bits (179), Expect = 2e-12
 Identities = 205/1016 (20%), Positives = 397/1016 (39%), Gaps = 214/1016 (21%)

Query: 26   ELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVL 85
            +L + I +LQ   D+++  +   E ++Q  LAR          D TL K   +  L  V 
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALAR--------GDDETLHK---NNALKVVR 1114

Query: 86   EADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHKQIYRLAVKEVDPQVNWAALVEEK 145
            E  A IA+         + ED    K      R K ++  R   +E++      AL  E 
Sbjct: 1115 ELQAQIAE---------LQEDFESEKAS----RNKAEKQKRDLSEELE------ALKTEL 1155

Query: 146  LDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKDGDKEQNSELRAKYQKLLAAS 205
             D L+  +   +L     Q         EV  +     K   +E+     A+ Q +    
Sbjct: 1156 EDTLDTTAAQQELRTKREQ---------EVAEL-----KKALEEETKNHEAQIQDM---- 1197

Query: 206  QARQQHLSSLQDYMQRCTNELYWLDQQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEA 265
              RQ+H ++L++  ++       L+Q  + +   + + + L+  ++    E  + + ++A
Sbjct: 1198 --RQRHATALEELSEQ-------LEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA 1248

Query: 266  KEE--------RINKLH---SEGDQLLAAEHPGRNSIEAHMEAVHADWKEYLNLLICEES 314
            + E        ++ +LH   SEGD+L        + ++  ++ V    +E       E+ 
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE------AEKK 1302

Query: 315  HLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELLLRELDDQEKVLDKY 374
             +K+ +D       ++D QELL++           + + +  +   +R+L++++  L + 
Sbjct: 1303 GIKFAKDAASLESQLQDTQELLQE-----------ETRQKLNLSSRIRQLEEEKNSLQEQ 1351

Query: 375  EDVVQGLQKR-GQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRGYSYTLQKNNGESW 433
            ++  +  +K   +QV+ L+ +     K +        + + G I                
Sbjct: 1352 QEEEEEARKNLEKQVLALQSQLADTKKKV--------DDDLGTI---------------- 1387

Query: 434  ELMDSAGNKLIAPAVCFVIPPTDPEALALADSLGSQYRSVRQKAAGSKRTLQQRYEVLKT 493
            E ++ A  KL+             +A AL+  L  +      K   +K  LQQ  + L  
Sbjct: 1388 ESLEEAKKKLL------------KDAEALSQRL-EEKALAYDKLEKTKNRLQQELDDLTV 1434

Query: 494  ENPGDASDLQGRQLLAGLDKVASDLDR---QEKAITGILRPPLEQGRAVQDSAE---RAK 547
            +      D Q RQ+ + L+K     D+   +EK+I+   R   E+ RA  ++ E   +A 
Sbjct: 1435 D-----LDHQ-RQVASNLEKKQKKFDQLLAEEKSISA--RYAEERDRAEAEAREKETKAL 1486

Query: 548  DLKNITNELLRIEPEKTRSTAEGEAFIQALPGS------------GTTPLLRTRVEDTNR 595
             L     E L  + E  R   +  A ++ L  S             +   L  +VE+   
Sbjct: 1487 SLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRT 1546

Query: 596  KYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENHL-NQDDTVPESSRVLDSKGQE 654
            + E   +L D  Q   D   RLE ++Q    + A  E  L  +D+   E  R+L  + +E
Sbjct: 1547 QLE---ELEDELQATEDAKLRLEVNMQ---AMKAQFERDLQTRDEQNEEKKRLLIKQVRE 1600

Query: 655  LAAMACELQAQKSL-----------LGEVEQNLQAAKQCSSTLAS---RFQEHCPDLERQ 700
            L A   + + Q++L           L ++E  ++AA +    +     + Q    D +R+
Sbjct: 1601 LEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRE 1660

Query: 701  EAEVH-----------KLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSI 749
              E             +  ++  +L  ++ +  + L S++ A  H  +  D +       
Sbjct: 1661 LEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD----- 1715

Query: 750  PSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLR 809
                 + T+S S     L  ++ L   IA  E+E+++  +N +      +   L+ + L 
Sbjct: 1716 -----EITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN 1770

Query: 810  SLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQ 869
            + L  E   ++  S  AR Q     ++ +   L AK  E+    + + +    AL     
Sbjct: 1771 AELAAERS-AAQKSDNARQQ-----LERQNKELKAKLQELEGAVKSKFKATISALEAKIG 1824

Query: 870  QPEVEVTHETLQRNRPDSGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQ 929
            Q E ++  E  +R   +  V    K  KE+  + E  R+  ++ K   E           
Sbjct: 1825 QLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQME----------- 1873

Query: 930  ESVVRKEVLKKVPDPVLEE------SFQQLQRTLAEEQHKNQLLQEELEALQLQLR 979
            ++  R + LK+  +   EE      S ++LQR L +    N+ L  E+  L+ +LR
Sbjct: 1874 KANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929



 Score = 66.2 bits (160), Expect = 3e-10
 Identities = 169/831 (20%), Positives = 320/831 (38%), Gaps = 146/831 (17%)

Query: 7    KRNKGKYSPTVQTRSISNKELSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPE 66
            K ++ +     Q  + + +ELSE +EQ ++    +EKN    E   +     ++  +Q +
Sbjct: 1188 KNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVK 1247

Query: 67   HRDVTLQKVLDSEKLLYVLEADAAIAKHMKHPQGDM----IAEDIRQLKERVTNLRGKHK 122
                  +K LD++    V E       H K  +GD     +AE   +L+  + N+    +
Sbjct: 1248 AESEHKRKKLDAQ----VQEL------HAKVSEGDRLRVELAEKASKLQNELDNVSTLLE 1297

Query: 123  QIYRLAVK--------EVDPQVNWAALVEEKLDKLNNQSFGTDL-----PLVDHQVEEHN 169
            +  +  +K        E   Q     L EE   KLN  S    L      L + Q EE  
Sbjct: 1298 EAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEE 1357

Query: 170  IFHN---EVKAIGPHLAKDGDKEQNSELRAKYQKLLAASQARQQHLSSLQDYMQRCTNEL 226
               N   +V A+   LA D  K+ + +L      + +  +A+++ L   +   QR   + 
Sbjct: 1358 ARKNLEKQVLALQSQLA-DTKKKVDDDLGT----IESLEEAKKKLLKDAEALSQRLEEKA 1412

Query: 227  YWLD--QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLA-- 282
               D  ++ K R+Q +  D  +D   +R+     +  NLE K+++ ++L +E   + A  
Sbjct: 1413 LAYDKLEKTKNRLQQELDDLTVDLDHQRQ-----VASNLEKKQKKFDQLLAEEKSISARY 1467

Query: 283  AEHPGRNSIEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSD 342
            AE   R   EA  +   A     L+L    E  L+  E++ + ++ ++   E L     D
Sbjct: 1468 AEERDRAEAEAREKETKA-----LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDD 1522

Query: 343  LNQKYGPDFKDRYQIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPI 402
            + +      K +  +E  + E+  Q   L++ ED +Q  +         K R E  ++ +
Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRTQ---LEELEDELQATE-------DAKLRLEVNMQAM 1572

Query: 403  PVEALCDFEGEQGLISRGYSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALAL 462
              +   D +            T  + N E   L+     +L A                L
Sbjct: 1573 KAQFERDLQ------------TRDEQNEEKKRLLIKQVRELEA---------------EL 1605

Query: 463  ADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQE 522
             D      R  R  A  SK+ ++   ++   E   +A++    +++  L K+ + +   +
Sbjct: 1606 EDE-----RKQRALAVASKKKME--IDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQ 1658

Query: 523  KAITGILRPPLEQGRAVQD-----SAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQAL 577
            +         LE+ RA +D     S E  K LK++  E+L+++ E   S           
Sbjct: 1659 R--------ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE---------- 1700

Query: 578  PGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEK---VDVANRLEKSLQQSWELLATHENH 634
                     R R      + E   ++ + A  K   +D   RLE  + Q  E L   +++
Sbjct: 1701 ---------RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSN 1751

Query: 635  LN-QDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAK----QCSSTLASR 689
            +   +D   +++  +D+   ELAA     Q   +   ++E+  +  K    +    + S+
Sbjct: 1752 MELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSK 1811

Query: 690  FQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSI 749
            F+     LE       K+GQ    L Q+ + RA       AA +   R    + +  + +
Sbjct: 1812 FKATISALEA------KIGQLEEQLEQEAKERA-------AANKLVRRTEKKLKEIFMQV 1858

Query: 750  PSYEPQETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKD 800
                        QME      K L  ++   E+E  +  A+ ++ Q+ + D
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDD 1909


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  158 bits (399), Expect = 5e-38
 Identities = 224/1117 (20%), Positives = 480/1117 (42%), Gaps = 172/1117 (15%)

Query: 611  VDVANRLEKSLQQSWELLATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLG 670
            + V+ + E+ + +  EL+   E  L  ++ + E   +      E   +  +LQA+  L  
Sbjct: 838  LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCA 897

Query: 671  EVEQ---NLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQS 727
            E E+    L A KQ         +E C DLE   A V +  +R  +L+ + ++  Q++Q 
Sbjct: 898  EAEELRARLTAKKQ-------ELEEICHDLE---ARVEEEEERCQHLQAEKKKMQQNIQE 947

Query: 728  AKAAYEHFHRGHDHV-LQFLVSIPSYEPQETDS--LSQMETKLKNQKNLLDE-------- 776
             +   E        + L+ + +    +  E +   L     KL  +K LL++        
Sbjct: 948  LEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTN 1007

Query: 777  IASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVK 836
            +   E++ + +     +++  + D E   E+LR     E  R      R +L+  +T + 
Sbjct: 1008 LTEEEEKSKSLAKLKNKHEAMITDLE---ERLRRE---EKQRQELEKTRRKLEGDSTDLS 1061

Query: 837  EEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIR 896
            ++ A L A+  E+     ++ + L+ AL          V  E  Q+N     + E     
Sbjct: 1062 DQIAELQAQIAELKMQLAKKEEELQAAL--------ARVEEEAAQKNMALKKIRELESQI 1113

Query: 897  KELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRT 956
             EL E+ E  R   N+ +  + ++               E LK   +  L+ +  Q +  
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGE-----------ELEALKTELEDTLDSTAAQQELR 1162

Query: 957  LAEEQHKNQL---LQEELEALQLQLRALEQETRDGGQEYV--VKEVLRIEPDRAQADEVL 1011
               EQ  N L   L+EE +  + Q++ + Q+     +E    +++  R++ +  +A + L
Sbjct: 1163 SKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTL 1222

Query: 1012 Q-----LREELEALRRQKGARE-----AEVLLLQQRVAALAEEKSRAQ--EKVTEKEVVK 1059
            +     L  E++ L + KG  E      E  L + +V     E+ R +  +KVT+ +V +
Sbjct: 1223 ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQV-E 1281

Query: 1060 LQN-----------DPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMA 1108
            L N             +L  ++  L+   Q   +L +++  +   L  KLK++E E+   
Sbjct: 1282 LDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSF 1341

Query: 1109 EGKITVKEVLK--VEKDAAT-EREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEEN 1165
              ++  +E  K  +EK  AT   +V+D+ ++ ED       ++  K +L + +  L + +
Sbjct: 1342 REQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRH 1401

Query: 1166 A-KVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSY------------ 1212
              KV   +K+    +   + + E+ +L ++L  Q +     E++ + +            
Sbjct: 1402 EEKVAAYDKLE---KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA 1458

Query: 1213 -------QSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERC 1265
                   ++E EA  +    + +    +E ++ K   E+E+  ++ R E+ D     +  
Sbjct: 1459 KYAEERDRAEAEAREKETKALSLARALEEAMEQKA--ELERLNKQFRTEMEDLMSSKDDV 1516

Query: 1266 DLEIYQLKKEIQALKDTKPQVQTK-EVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVD 1324
               +++L+K  +AL+    +++T+ E +++ LQ  ED + + EV          Q  +  
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEV--------NLQAMKAQ 1568

Query: 1325 LERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQID- 1383
             ER+   ++EQ   K+++L R     V++     E+E   R+ A A  + ++++L+ ++ 
Sbjct: 1569 FERDLQGRDEQSEEKKKQLVRQ----VREMEAELEDERKQRSMAVAARKKLEMDLKDLEA 1624

Query: 1384 ------KLRAE-LRRLQRRRTELERQLEELERERQARREAEREVQRLQQRLAALEQEEAE 1436
                  K R E +++L++ + +++  + EL+  R +R E   + +  +++L ++E E  +
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684

Query: 1437 AREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVK 1496
             +E++   ++   ++  QQ R+   L  ++     +  L   E   L  ++A LE     
Sbjct: 1685 LQEELAAAERA--KRQAQQERDE--LADEIANSSGKGALALEEKRRLEARIAQLE----- 1735

Query: 1497 EKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSK 1556
                  E ++ E+G+TE    RLK +  +  +   +L++E S  +               
Sbjct: 1736 ------EELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQ--------------- 1774

Query: 1557 ELDFLREENHKLQLERQNLQLETRRLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLE 1616
                 + EN + QLERQN +L+ +  + E  + +     +         T  ++++  LE
Sbjct: 1775 -----KNENARQQLERQNKELKVKLQEMEGTVKSKYKASI---------TALEAKIAQLE 1820

Query: 1617 RELDDLKRLSKDKDLEIDELQKRLGSVAVK-REQREN 1652
             +LD+  +  +    ++   +K+L  V ++  ++R N
Sbjct: 1821 EQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRN 1857



 Score =  146 bits (369), Expect = 2e-34
 Identities = 239/1151 (20%), Positives = 478/1151 (41%), Gaps = 121/1151 (10%)

Query: 463  ADSLGSQYRSVRQKAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAG--LDKVASDLDR 520
            A++  ++  +++ +    K  LQ++ +  +TE   +A +L+ R       L+++  DL+ 
Sbjct: 864  AENRLTEMETLQSQLMAEKLQLQEQLQA-ETELCAEAEELRARLTAKKQELEEICHDLEA 922

Query: 521  QEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGS 580
            + +          E+ R     AE+ K  +NI     ++E E++   A  +  ++ +   
Sbjct: 923  RVEE---------EEERCQHLQAEKKKMQQNIQELEEQLEEEES---ARQKLQLEKVTTE 970

Query: 581  GTTPLLRTR---VEDTNRKYEHLLQLLD--LAQEKVDVANRLEKS-----LQQSWELLAT 630
                 L      +ED N K     +LL+  +A+   ++    EKS     L+   E + T
Sbjct: 971  AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMIT 1030

Query: 631  H-ENHLNQDDT----VPESSRVLDSKGQELAAMACELQAQ----KSLLGEVEQNLQAAK- 680
              E  L +++     + ++ R L+    +L+    ELQAQ    K  L + E+ LQAA  
Sbjct: 1031 DLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALA 1090

Query: 681  -------------QCSSTLASRFQEHCPDLERQEAEVHKLGQRFNNLRQQVERRAQSLQS 727
                         +    L S+  E   DLE + A  +K  ++  +L +++E     L+ 
Sbjct: 1091 RVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED 1150

Query: 728  ---AKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASREQEV 784
               + AA +      +  +  L    + E +     +Q++   +     ++E+A + ++ 
Sbjct: 1151 TLDSTAAQQELRSKREQEVNILKK--TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQT 1208

Query: 785  QKICANSQQYQQAVKDYELEAEKLRSLLDLENGRSSHVSKRARLQSPATKVKEEEAA--- 841
            +++ AN ++ +Q +++   E      +L    G S H  K+   Q    +VK  E     
Sbjct: 1209 KRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR 1268

Query: 842  --LAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPDSGVEEAWKIRKEL 899
              LA K T++          L+    LL Q        ++ +  +  S +E   +  +EL
Sbjct: 1269 TELADKVTKLQV-------ELDNVTGLLSQSDS-----KSSKLTKDFSALESQLQDTQEL 1316

Query: 900  -DEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLA 958
              EE  ++  L  ++K  ++E  + R Q  +E   +  + K++    L      +++ + 
Sbjct: 1317 LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIA--TLHAQVADMKKKME 1374

Query: 959  EEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELE 1018
            +     +  +E    LQ  L  L Q   +    Y   E  +    +   D ++ L  + +
Sbjct: 1375 DSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQ 1434

Query: 1019 -ALRRQKGAREAEVLLLQQRV--AALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQE 1075
             A   +K  ++ + LL +++   A  AEE+ RA+ +  EKE   L     LE   +Q  E
Sbjct: 1435 SACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE 1494

Query: 1076 DHQRQDQLREKQEEELSFLQD---KLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSD 1132
              +   Q R + E+ +S   D    +  LEK +   E ++   E +K + +     E+ D
Sbjct: 1495 LERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQV---EEMKTQLE-----ELED 1546

Query: 1133 LTRQYEDEAAKARAS-QREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANL 1191
              +  ED   +   + Q  K +  R +   +E++     +EK +++VR   + E+E+ + 
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS-----EEKKKQLVRQVREMEAELEDE 1601

Query: 1192 RLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRL 1251
            R +        +  E  L+  ++ +++  +   +  +K++ K   + K       + +  
Sbjct: 1602 RKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA-IKQLRKLQAQMKDCMRELDDTRAS 1660

Query: 1252 REEIV----DKTRLIERCDLEIYQLKKEIQALKDTKPQVQTK--EVVQEI--------LQ 1297
            REEI+    +  + ++  + E+ QL++E+ A +  K Q Q +  E+  EI        L 
Sbjct: 1661 REEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALA 1720

Query: 1298 FQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVR 1357
             +E  + +  +A L  +L EEQ     +         QI +   +L+  +    + E  R
Sbjct: 1721 LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR 1780

Query: 1358 YEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQAR-REA 1416
             + E   R       +  ++E     K +A +  L+ +  +LE QL+   +ERQA  ++ 
Sbjct: 1781 QQLE---RQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQV 1837

Query: 1417 EREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLL 1476
             R  ++L+  L  ++ E   A +          Q D    R   L R QLEE +   Q  
Sbjct: 1838 RRTEKKLKDVLLQVDDERRNAEQYKD-------QADKASTRLKQLKR-QLEEAEEEAQRA 1889

Query: 1477 EGELETLRRKLA-ALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDV 1535
                  L+R+L  A E A+   + V S   ++ +GD    + R  +       S  E+D 
Sbjct: 1890 NASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDG 1949

Query: 1536 EVSRLEARLSE 1546
            +    EA+ +E
Sbjct: 1950 KADGAEAKPAE 1960



 Score =  137 bits (346), Expect = 7e-32
 Identities = 166/738 (22%), Positives = 340/738 (46%), Gaps = 60/738 (8%)

Query: 950  FQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADE 1009
            F +++  L   + + +++ +E E ++++ + L  E R    E +  +++    ++ Q  E
Sbjct: 831  FTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMA---EKLQLQE 887

Query: 1010 VLQLREEL----EALRRQKGAREAEVL-LLQQRVAALAEEKSRAQEKVTEKEVVKLQNDP 1064
             LQ   EL    E LR +  A++ E+  +     A + EE+ R Q    EK+        
Sbjct: 888  QLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK-------- 939

Query: 1065 QLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDA 1124
            +++   Q+L+E  + ++  R+K + E    + KLK+LE+E+ + E +      L  EK  
Sbjct: 940  KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCK---LAKEKKL 996

Query: 1125 ATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVR-EIVRPDPK 1183
              +R +++ T    +E  K+++  + K +    I  LEE   +   +EK R E+ +   K
Sbjct: 997  LEDR-IAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRR---EEKQRQELEKTRRK 1052

Query: 1184 AESEVANLRLELVEQERKYRGAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE 1243
             E +  +L  ++ E + +    + QL   + EL+A   R   VE +E  ++ +  K   E
Sbjct: 1053 LEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALAR---VE-EEAAQKNMALKKIRE 1108

Query: 1244 MEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQ 1303
            +E ++  L+E++  +     + + +   L +E++ALK            Q+ L+ + +  
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE-- 1166

Query: 1304 TKEEVASLRAKLSEEQK---KQVDLERERASQE-EQIARKEEELSRVKERVVQQEVVRYE 1359
              +EV  L+  L EE K    Q+   R++ SQ  E++A + E+  RVK  + + +     
Sbjct: 1167 --QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN 1224

Query: 1360 EEPGLRAEASAFAESIDVELRQIDKLRAELRRLQ-------RRRTELERQLEELERERQ- 1411
            E   L  E     +       +  K+ A+L+ LQ       R RTEL  ++ +L+ E   
Sbjct: 1225 ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDN 1284

Query: 1412 ---ARREAEREVQRLQQRLAALEQEEAEARE--KVTHTQKVVLQQDPQQAR-EHALLRLQ 1465
                  +++ +  +L +  +ALE +  + +E  +  + QK+ L    +Q   E    R Q
Sbjct: 1285 VTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQ 1344

Query: 1466 LEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEE 1525
            LEEE+  +  LE ++ TL  ++A ++K ++++ V   E+ +  K   +++++ L    EE
Sbjct: 1345 LEEEEEAKHNLEKQIATLHAQVADMKK-KMEDSVGCLETAEEVKRKLQKDLEGLSQRHEE 1403

Query: 1526 ESRSKRELDVEVSRLEARLSELEF---HNSKSSKELDFLREENHKLQLERQNLQLE--TR 1580
            +  +  +L+   +RL+  L +L     H  +S+  L+  +++  +L  E + +  +    
Sbjct: 1404 KVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE 1463

Query: 1581 RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLER----ELDDLKRLSKDKDLEIDEL 1636
            R ++E      ET+ L      +      + L  L +    E++DL     D    + EL
Sbjct: 1464 RDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL 1523

Query: 1637 QKRLGSVAVKREQRENHL 1654
            +K   ++  + E+ +  L
Sbjct: 1524 EKSKRALEQQVEEMKTQL 1541



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 229/1178 (19%), Positives = 449/1178 (38%), Gaps = 211/1178 (17%)

Query: 25   KELSELIEQLQKNADQVEKNIVDTEA---KMQSDLARLQEGRQPE---HRDVTLQKVLDS 78
            +EL E+   L+   ++ E+     +A   KMQ ++  L+E  + E    + + L+KV   
Sbjct: 911  QELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTE 970

Query: 79   EKL-------LYVLEADAAIAKHMKHPQGDMIAEDIRQLKER------VTNLRGKHKQIY 125
             KL       + + + +  +AK  K  + D IAE    L E       +  L+ KH+ + 
Sbjct: 971  AKLKKLEEEQIILEDQNCKLAKEKKLLE-DRIAEFTTNLTEEEEKSKSLAKLKNKHEAM- 1028

Query: 126  RLAVKEVDPQVNWAALVEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLAKD 185
               + +++ ++       ++L+K   +  G    L D   E       ++  +   LAK 
Sbjct: 1029 ---ITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAE----LQAQIAELKMQLAKK 1081

Query: 186  GDKEQNSELRAK---YQKLLAASQAR--QQHLSSLQDYMQRCTNELYWLDQQAKGRMQYD 240
             ++ Q +  R +    QK +A  + R  +  +S LQ+ ++         ++ ++ + +  
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLES--------ERASRNKAEKQ 1133

Query: 241  WSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNSIEAHMEAVHA 300
              D   +  + + + E+ ++ +  A++E  +K   E + L       + ++E   +   A
Sbjct: 1134 KRDLGEELEALKTELEDTLD-STAAQQELRSKREQEVNIL-------KKTLEEEAKTHEA 1185

Query: 301  DWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPDFKDRYQIELL 360
              +E        + H + +E+  +  E  K  +  L K    L  + G   +   ++++L
Sbjct: 1186 QIQE------MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERG---ELANEVKVL 1236

Query: 361  LRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRETPLKPIPVEALCDFEGEQGLISRG 420
            L+   D E    K E  +Q LQ +  +      R  T L     +   + +   GL+S+ 
Sbjct: 1237 LQGKGDSEHKRKKVEAQLQELQVKFNE----GERVRTELADKVTKLQVELDNVTGLLSQS 1292

Query: 421  YSYTLQKNNGESWELMDSAGNKLIAPAVCFVIPPTDPEALALAD-----SLGSQYRSVRQ 475
                            DS  +KL            D + L   +     SL ++ + V  
Sbjct: 1293 ----------------DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVED 1336

Query: 476  KAAGSKRTLQQRYEVLKTENPGDASDLQGRQLLAGLDKVASDLDRQEKAITGILRPPLEQ 535
            +    +  L++  E                + +A L    +D+ ++ +   G L    E 
Sbjct: 1337 EKNSFREQLEEEEEAKHNL----------EKQIATLHAQVADMKKKMEDSVGCLETAEEV 1386

Query: 536  GRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFIQALPGSGTTPLLRTRVEDTNR 595
             R +Q      KDL+ ++        EK  +  + E          T   L+  ++D   
Sbjct: 1387 KRKLQ------KDLEGLSQR----HEEKVAAYDKLEK---------TKTRLQQELDDL-- 1425

Query: 596  KYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHE----NHLNQDDTVPESSRVLDSK 651
                   L+DL  ++    N LEK  ++  +LLA  +     +  + D     +R  ++K
Sbjct: 1426 -------LVDLDHQRQSACN-LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETK 1477

Query: 652  GQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHCPDLERQEAEVHKLGQRF 711
               LA    E   QK+ L  +  N Q   +    ++S+        +     VH+L +  
Sbjct: 1478 ALSLARALEEAMEQKAELERL--NKQFRTEMEDLMSSK--------DDVGKSVHELEKSK 1527

Query: 712  NNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEPQ-ETDSLSQMETKLKNQ 770
              L QQVE     L+  +   +      D  L+  V++ + + Q E D   + E   + +
Sbjct: 1528 RALEQQVEEMKTQLEELE---DELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKK 1584

Query: 771  KNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLEN-GRSSHVSKRARLQ 829
            K L+ ++   E E++           A K  E++ + L + +D  N  R   + +  +LQ
Sbjct: 1585 KQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQ 1644

Query: 830  SPATKVKEEEAALAAKFTEVYA---INRQRLQNLEFALNLLRQQPEVEVTHETLQRNRPD 886
            +       E     A   E+ A    N ++L+++E                         
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKENEKKLKSME------------------------- 1679

Query: 887  SGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVL 946
                E  ++++EL      +RQ + E     +EI     +G      ++          L
Sbjct: 1680 ---AEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRR---------L 1727

Query: 947  EESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQ 1006
            E    QL+  L EEQ   +L+ + L+   LQ+  +  +             L +E   AQ
Sbjct: 1728 EARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTD-------------LNLERSHAQ 1774

Query: 1007 ADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQL 1066
             +E    R++LE   RQ   +E +V L +         KS+ +  +T  E    Q + QL
Sbjct: 1775 KNE--NARQQLE---RQN--KELKVKLQEME----GTVKSKYKASITALEAKIAQLEEQL 1823

Query: 1067 EAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAAT 1126
            + E ++ Q   ++  +  +K ++ L  + D+ +  E+ +  A+   T  + LK + + A 
Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE 1883

Query: 1127 ER------EVSDLTRQYEDEAAKARASQREKTELLRKI 1158
            E           L R+ ED    A A  RE + L  K+
Sbjct: 1884 EEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 68/274 (24%), Positives = 131/274 (47%), Gaps = 37/274 (13%)

Query: 1419 EVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEG 1478
            +V R ++ + A E+E  + REK    +  + + +  Q++  A  +LQL+E+      L  
Sbjct: 839  QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAE-KLQLQEQLQAETELCA 897

Query: 1479 ELETLRRKLAALEK----------AEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESR 1528
            E E LR +L A ++          A V+E+    + +Q EK   +Q IQ L+  LEEE  
Sbjct: 898  EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEES 957

Query: 1529 SKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLETRRLQSEINM 1588
            ++++L +E    EA+L +LE       +E   L ++N KL  E++   LE R  +   N+
Sbjct: 958  ARQKLQLEKVTTEAKLKKLE-------EEQIILEDQNCKLAKEKK--LLEDRIAEFTTNL 1008

Query: 1589 AATETRDLRNMTVADSGTNHDSRLWSLE----------RELDDLKRL----SKDKDLEID 1634
               E +   + ++A     H++ +  LE          +EL+  +R     S D   +I 
Sbjct: 1009 TEEEEK---SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIA 1065

Query: 1635 ELQKRLGSVAVKREQRENHLRRSIVVIHPDTGRE 1668
            ELQ ++  + ++  ++E  L+ ++  +  +  ++
Sbjct: 1066 ELQAQIAELKMQLAKKEEELQAALARVEEEAAQK 1099


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.128    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 61,783,285
Number of Sequences: 37866
Number of extensions: 2920269
Number of successful extensions: 55296
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 686
Number of HSP's successfully gapped in prelim test: 1464
Number of HSP's that attempted gapping in prelim test: 13968
Number of HSP's gapped (non-prelim): 14023
length of query: 1756
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1640
effective length of database: 13,855,062
effective search space: 22722301680
effective search space used: 22722301680
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.