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Search of human proteins with 45359873
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45359873 OGT(O-Glc-NAc transferase)-interacting protein 106
KDa isoform 2 [Homo sapiens]
(686 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45359873 OGT(O-Glc-NAc transferase)-interacting protein 106 K... 1347 0.0
gi|111074532 OGT(O-Glc-NAc transferase)-interacting protein 106 ... 1090 0.0
gi|188497667 trafficking protein, kinesin binding 2 [Homo sapiens] 516 e-146
gi|120431738 huntingtin-associated protein 1 isoform 2 [Homo sap... 145 9e-35
gi|120431745 huntingtin-associated protein 1 isoform 4 [Homo sap... 131 2e-30
gi|120431743 huntingtin-associated protein 1 isoform 3 [Homo sap... 129 9e-30
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 67 4e-11
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 67 7e-11
gi|71061468 centromere protein E [Homo sapiens] 66 9e-11
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 66 1e-10
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 65 2e-10
gi|119120918 coiled-coil domain containing 64 [Homo sapiens] 64 6e-10
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 63 8e-10
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 63 8e-10
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 62 2e-09
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 61 3e-09
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 60 5e-09
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 60 5e-09
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 60 5e-09
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 60 5e-09
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap... 60 7e-09
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C... 60 7e-09
gi|221219020 NYD-SP11 protein [Homo sapiens] 60 9e-09
gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo sapi... 60 9e-09
gi|157502225 Janus kinase and microtubule interacting protein 3 ... 59 1e-08
gi|21735548 centrosomal protein 2 [Homo sapiens] 59 1e-08
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 59 1e-08
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi... 59 1e-08
gi|38044112 restin isoform b [Homo sapiens] 59 2e-08
gi|4506751 restin isoform a [Homo sapiens] 59 2e-08
>gi|45359873 OGT(O-Glc-NAc transferase)-interacting protein 106 KDa
isoform 2 [Homo sapiens]
Length = 686
Score = 1347 bits (3486), Expect = 0.0
Identities = 686/686 (100%), Positives = 686/686 (100%)
Query: 1 MSLRDKGGEEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRL 60
MSLRDKGGEEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRL
Sbjct: 1 MSLRDKGGEEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRL 60
Query: 61 LEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFY 120
LEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFY
Sbjct: 61 LEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFY 120
Query: 121 TSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTET 180
TSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTET
Sbjct: 121 TSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTET 180
Query: 181 ITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKA 240
ITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKA
Sbjct: 181 ITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKA 240
Query: 241 KACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNT 300
KACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNT
Sbjct: 241 KACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNT 300
Query: 301 TSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSL 360
TSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSL
Sbjct: 301 TSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSL 360
Query: 361 TPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGND 420
TPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGND
Sbjct: 361 TPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGND 420
Query: 421 ERSKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSL 480
ERSKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSL
Sbjct: 421 ERSKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSL 480
Query: 481 TPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLG 540
TPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLG
Sbjct: 481 TPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLG 540
Query: 541 GILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSGERS 600
GILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSGERS
Sbjct: 541 GILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGDHISLPRLATSTPVQHPETSGERS 600
Query: 601 QARVTVSGSRSYPSRPQASPEEMQEPPAATEEEEEEEEEEGSGEGTTISPVNLAPFPEAE 660
QARVTVSGSRSYPSRPQASPEEMQEPPAATEEEEEEEEEEGSGEGTTISPVNLAPFPEAE
Sbjct: 601 QARVTVSGSRSYPSRPQASPEEMQEPPAATEEEEEEEEEEGSGEGTTISPVNLAPFPEAE 660
Query: 661 FWAILTSVPGTIRSGSLSVASARLCG 686
FWAILTSVPGTIRSGSLSVASARLCG
Sbjct: 661 FWAILTSVPGTIRSGSLSVASARLCG 686
>gi|111074532 OGT(O-Glc-NAc transferase)-interacting protein 106 KDa
isoform 1 [Homo sapiens]
Length = 953
Score = 1090 bits (2819), Expect = 0.0
Identities = 558/559 (99%), Positives = 559/559 (100%)
Query: 38 VLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVE 97
+LCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVE
Sbjct: 96 LLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVE 155
Query: 98 HIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQK 157
HIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQK
Sbjct: 156 HIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQK 215
Query: 158 KLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTE 217
KLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTE
Sbjct: 216 KLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTE 275
Query: 218 DAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAE 277
DAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAE
Sbjct: 276 DAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAE 335
Query: 278 CMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPD 337
CMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPD
Sbjct: 336 CMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPD 395
Query: 338 ITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIG 397
ITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIG
Sbjct: 396 ITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIG 455
Query: 398 NVVLDNKTNSIILETEAADLGNDERSKKPGTPGTPGSHDLETALRRLSLRRENYLSERRF 457
NVVLDNKTNSIILETEAADLGNDERSKKPGTPGTPGSHDLETALRRLSLRRENYLSERRF
Sbjct: 456 NVVLDNKTNSIILETEAADLGNDERSKKPGTPGTPGSHDLETALRRLSLRRENYLSERRF 515
Query: 458 FEEEQERKLQELAEKGELRSGSLTPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQ 517
FEEEQERKLQELAEKGELRSGSLTPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQ
Sbjct: 516 FEEEQERKLQELAEKGELRSGSLTPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQ 575
Query: 518 IVKPLEGSATLHHWQQLAQPHLGGILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGD 577
IVKPLEGSATLHHWQQLAQPHLGGILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGD
Sbjct: 576 IVKPLEGSATLHHWQQLAQPHLGGILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDDTGD 635
Query: 578 HISLPRLATSTPVQHPETS 596
HISLPRLATSTPVQHPETS
Sbjct: 636 HISLPRLATSTPVQHPETS 654
>gi|188497667 trafficking protein, kinesin binding 2 [Homo sapiens]
Length = 914
Score = 516 bits (1329), Expect = e-146
Identities = 304/574 (52%), Positives = 384/574 (66%), Gaps = 33/574 (5%)
Query: 13 FEYDCQDEERKPTHRQHDTQDLLEEVLCAE----------RVGQMTKTYNDIDAVTRLLE 62
F Y+ QD + P RQH D L VL E RV QMTKTYNDID VT LL
Sbjct: 62 FLYENQDWTQSPHQRQH-ASDALSPVLAEETFRYMILGTDRVEQMTKTYNDIDMVTHLLA 120
Query: 63 EKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTS 122
E++RDLELAARIGQ+LLK+N L+E+NE LEEQ+ ++V+QL+HEL KDELL+ +
Sbjct: 121 ERDRDLELAARIGQALLKRNHVLSEQNESLEEQLGQAFDQVNQLQHELCKKDELLRIVSI 180
Query: 123 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETIT 182
A+EESE +S CSTPL+ NES S Q L+ LQ+KLK+LEEEN+ LRS+A +KTET+T
Sbjct: 181 ASEESETDSSCSTPLRFNESFSLSQGLLQLEMLQEKLKELEEENMALRSKACHIKTETVT 240
Query: 183 YEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKA 242
YEEKEQQLV+DCVKELR+ N Q++ ++EEL+ K+++ R QEE++ LLSQIVDLQ K K
Sbjct: 241 YEEKEQQLVSDCVKELRETNAQMSRMTEELSGKSDELIRYQEELSSLLSQIVDLQHKLKE 300
Query: 243 CAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTS 302
+E EEL HL A+KDAQRQLT EL EL+D+ EC+ MLHE+QEE+K LR+++ P
Sbjct: 301 HVIEKEELKLHLQASKDAQRQLTMELHELQDRNMECLGMLHESQEEIKELRSRSGPTAHL 360
Query: 303 RRYHSLGLFPMDSLAAEIEGTMRKELQLEEAES--PDITHQKRVFETVRNINQVVKQRSL 360
S G F +SLAAEIEGTMRK+L L+E S QKRVF+TVR N +
Sbjct: 361 YFSQSYGAFTGESLAAEIEGTMRKKLSLDEESSLFKQKAQQKRVFDTVRIANDTRGRSIS 420
Query: 361 TPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGND 420
P+ + IPGSN+SS + + P S +L+ ++S E A
Sbjct: 421 FPALLPIPGSNRSSVI------MTAKPFESGLQQTEDKSLLNQGSSS----EEVAG---- 466
Query: 421 ERSKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSGSL 480
S+K G PG G DL TAL RLSLRR+NYLSE++FF EE +RK+Q LA++ E SG +
Sbjct: 467 -SSQKMGQPGPSGDSDLATALHRLSLRRQNYLSEKQFFAEEWQRKIQVLADQKEGVSGCV 525
Query: 481 TPTESIMSLGTHSRFSEFTGFSGMSFSSRSYLPEKLQIVKPLEGSATLHHWQQLAQPHLG 540
TPTES+ SL T SE T S S R ++PEKLQIVKPLEGS TL+HWQQLAQP+LG
Sbjct: 526 TPTESLASLCTTQ--SEITDLSSAS-CLRGFMPEKLQIVKPLEGSQTLYHWQQLAQPNLG 582
Query: 541 GILDPRPGVVTKGFRTLDVDLDEVYCLNDFEEDD 574
ILDPRPGV+TKGF L D +Y ++D EED+
Sbjct: 583 TILDPRPGVITKGFTQLPG--DAIYHISDLEEDE 614
>gi|120431738 huntingtin-associated protein 1 isoform 2 [Homo
sapiens]
Length = 619
Score = 145 bits (367), Expect = 9e-35
Identities = 110/327 (33%), Positives = 166/327 (50%), Gaps = 66/327 (20%)
Query: 35 LEEVLCAERVGQMTK-TYNDIDAVTRLLEE----------------KERDLELAARIGQS 77
LEE LC + K T D+ + LLEE +ERDL AARIGQS
Sbjct: 154 LEEALCPNLPPPVKKITQEDVKVMLYLLEELLPPVWESVTYGMVLQRERDLNTAARIGQS 213
Query: 78 LLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPES------ 131
L+K+N L E N LE + +EE+ LRH+++++DELLQ Y+ + EE E E
Sbjct: 214 LVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEK 273
Query: 132 -------------------VCSTPLKRNESSSSVQNYF-HLDSLQKKLKDLEEENVVLRS 171
C P ++ + Q++ L++LQ+KL+ LEEEN LR
Sbjct: 274 EAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLRE 333
Query: 172 EASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLS 231
EASQL T E++EQ L+ +CV++ +A+ Q+A +SE L + E+ RQQ+E+ L +
Sbjct: 334 EASQLD----TLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQA 389
Query: 232 QIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAE--LRELEDKYAECMEMLHEAQEEL 289
Q++ LQ++ + E E+L + L + K+ Q QL E L ++ AE E + L
Sbjct: 390 QVLKLQQRCRMYGAETEKLQKQLASEKEIQMQLQEEETLPGFQETLAE------ELRTSL 443
Query: 290 KNL---------RNKTMP--NTTSRRY 305
+ + RN MP +T+S RY
Sbjct: 444 RRMISDPVYFMERNYEMPRGDTSSLRY 470
>gi|120431745 huntingtin-associated protein 1 isoform 4 [Homo
sapiens]
Length = 594
Score = 131 bits (329), Expect = 2e-30
Identities = 88/250 (35%), Positives = 133/250 (53%), Gaps = 47/250 (18%)
Query: 35 LEEVLCAERVGQMTK-TYNDIDAVTRLLEE----------------KERDLELAARIGQS 77
LEE LC + K T D+ + LLEE +ERDL AARIGQS
Sbjct: 154 LEEALCPNLPPPVKKITQEDVKVMLYLLEELLPPVWESVTYGMVLQRERDLNTAARIGQS 213
Query: 78 LLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPES------ 131
L+K+N L E N LE + +EE+ LRH+++++DELLQ Y+ + EE E E
Sbjct: 214 LVKQNSVLMEENSKLEALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEK 273
Query: 132 -------------------VCSTPLKRNESSSSVQNYF-HLDSLQKKLKDLEEENVVLRS 171
C P ++ + Q++ L++LQ+KL+ LEEEN LR
Sbjct: 274 EAEEEQEEEEAEEDLQCAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLRE 333
Query: 172 EASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLS 231
EASQL T E++EQ L+ +CV++ +A+ Q+A +SE L + E+ RQQ+E+ L +
Sbjct: 334 EASQLD----TLEDEEQMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQA 389
Query: 232 QIVDLQKKAK 241
Q++ LQ++ +
Sbjct: 390 QVLKLQQRCR 399
>gi|120431743 huntingtin-associated protein 1 isoform 3 [Homo
sapiens]
Length = 602
Score = 129 bits (324), Expect = 9e-30
Identities = 82/234 (35%), Positives = 131/234 (55%), Gaps = 32/234 (13%)
Query: 34 LLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLE 93
LLEEV A + + + + ++ ++ERDL AARIGQSL+K+N L E N LE
Sbjct: 180 LLEEVCTAFLIQLLPPVWESV--TYGMVLQRERDLNTAARIGQSLVKQNSVLMEENSKLE 237
Query: 94 EQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPES---------------------- 131
+ +EE+ LRH+++++DELLQ Y+ + EE E E
Sbjct: 238 ALLGSAKEEILYLRHQVNLRDELLQLYSDSDEEDEDEEEEEEEKEAEEEQEEEEAEEDLQ 297
Query: 132 ---VCSTPLKRNESSSSVQNYF-HLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKE 187
C P ++ + Q++ L++LQ+KL+ LEEEN LR EASQL T E++E
Sbjct: 298 CAHPCDAPKLISQEALLHQHHCPQLEALQEKLRLLEEENHQLREEASQLD----TLEDEE 353
Query: 188 QQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAK 241
Q L+ +CV++ +A+ Q+A +SE L + E+ RQQ+E+ L +Q++ LQ++ +
Sbjct: 354 QMLILECVEQFSEASQQMAELSEVLVLRLENYERQQQEVARLQAQVLKLQQRCR 407
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 67.4 bits (163), Expect = 4e-11
Identities = 93/381 (24%), Positives = 163/381 (42%), Gaps = 71/381 (18%)
Query: 9 EEECFEYDCQDE--ERKPTHRQ-HDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKE 65
+ E E + Q+ E K T RQ + +D+L++ + + + Y I +T L E +
Sbjct: 1061 KREVLETELQNAHGELKSTLRQLQELRDVLQKAQLS-----LEEKYTTIKDLTAELRECK 1115
Query: 66 RDLELAARIGQSLLKKNKTLTERNELLEE---QVEHIREEVSQLRHELSMKDELLQFYTS 122
++E Q LL+ ++ L ERN L++ QV H+ + + R E+ K L+
Sbjct: 1116 MEIEDKK---QELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLE---G 1169
Query: 123 AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVL---RSEASQLKTE 179
E+SE L+ E + +++ D LQ + L E+ ++ E SQLK E
Sbjct: 1170 TLEKSE--------LELKECNKQIESLN--DKLQNAKEQLREKEFIMLQNEQEISQLKKE 1219
Query: 180 T-----------ITYEEKEQQLVN------DCVKELRDANVQIASISEELAKKTEDAARQ 222
+E+EQ + D +ELR Q+ + ELA+ +
Sbjct: 1220 IERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQA 1279
Query: 223 QEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEML 282
Q EI L S++ D+++ +K L + LGA+K + L A ++ K + +E L
Sbjct: 1280 QREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESL 1339
Query: 283 HEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEI----EGTMRKELQLEEAESPDI 338
EA M + + H+ DS + + E + +L+LEEA+
Sbjct: 1340 KEAYH---------MEMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQ---- 1386
Query: 339 THQKRVFETVRNINQVVKQRS 359
+TV N++Q V+ R+
Sbjct: 1387 -------DTVSNLHQQVQDRN 1400
Score = 51.6 bits (122), Expect = 2e-06
Identities = 72/316 (22%), Positives = 131/316 (41%), Gaps = 39/316 (12%)
Query: 46 QMTKTYNDIDAVTRLLEEKERDLELAAR---IGQSLLKKNKTL----TERNELLEEQVEH 98
Q+ K ++ + + L+ K L+ + I Q L++ + + T RN LE+
Sbjct: 875 QLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTK 934
Query: 99 IREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNE----SSSSVQNYFHLDS 154
+ ++VS+L EL + E EE + LKR + + ++ Q +D
Sbjct: 935 LEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQ 994
Query: 155 LQKKLKDLEEENVVLR----------SEASQLKTETITYEEKEQQLVNDCVKELRDANVQ 204
+++L +E+E + L+ S+ + +T T EK+ V + K +
Sbjct: 995 YKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETE 1054
Query: 205 IASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQL 264
+ ++ + E+ L Q+ +L+ + + EE + + L
Sbjct: 1055 LTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTI-------KDL 1107
Query: 265 TAELRE----LEDKYAECMEM---LHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLA 317
TAELRE +EDK E +EM L E ELK + + R H M+
Sbjct: 1108 TAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHR---GEMEQKI 1164
Query: 318 AEIEGTMRK-ELQLEE 332
++EGT+ K EL+L+E
Sbjct: 1165 IKLEGTLEKSELELKE 1180
Score = 47.0 bits (110), Expect = 6e-05
Identities = 89/384 (23%), Positives = 149/384 (38%), Gaps = 103/384 (26%)
Query: 41 AERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTL-------TERNELLE 93
+E + Q+T++ I + LE K+ L R SL+ +N+ L ER +L +
Sbjct: 445 SEVMAQLTESRQSILKLESELENKDEIL----RDKFSLMNENRELKVRVAAQNERLDLCQ 500
Query: 94 EQVEHIREEVSQLRH---ELSMKDELLQF--YTS-------------------------- 122
+++E R E+ L +L +K EL F Y S
Sbjct: 501 QEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVIS 560
Query: 123 ------AAEESEPESVCSTPLKRNESSSSV------QNYFHLDSLQKKLKDLEEENVVLR 170
A +E+E + + + L N+ S S+ Q L SL+ + L V
Sbjct: 561 ELRIKLAIKEAEIQKLHAN-LTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAES 619
Query: 171 SEASQLKTETITYEEKEQQLVNDCVKELRDANVQIAS------------------ISEEL 212
+ T YE++ Q+LV ++ELR +QI + I EEL
Sbjct: 620 VKDQNQHTMNKQYEKERQRLVTG-IEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEEL 678
Query: 213 AKKTEDAARQQEEITHLLSQIVDLQKKAK-------ACAVENEELVQHLGAAKDAQRQLT 265
+K ++++ + E+T SQ++ L+K+ + + A +N EL Q L + R L
Sbjct: 679 LEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLE 738
Query: 266 AELRELEDKYA---ECMEMLH--------------EAQEELKNLRNKTMPNTTSRRYHSL 308
+ +K E + +H EAQ E K+ + K T S +
Sbjct: 739 TNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDI 798
Query: 309 -----GLFPMDSLAAEIEGTMRKE 327
L +D L E +G M+KE
Sbjct: 799 ICKQHHLESLDRLLTESKGEMKKE 822
Score = 44.7 bits (104), Expect = 3e-04
Identities = 64/301 (21%), Positives = 134/301 (44%), Gaps = 35/301 (11%)
Query: 9 EEECFEYDC----QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEK 64
+EEC + Q ++ K RQ + E + AE + + + Y V LE+
Sbjct: 332 KEECIKLKVDLLEQTKQGKRAERQRN-----EALYNAEELSKAFQQYKK--KVAEKLEKV 384
Query: 65 ERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAA 124
+ + E+ R + K+NK L ER L + ++E ++E++ QL+ E + E L+ A
Sbjct: 385 QAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRI--MAV 442
Query: 125 EESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYE 184
+ SE + + + S Q+ L+S + ++ + L +E +LK
Sbjct: 443 KNSEVMA---------QLTESRQSILKLESELENKDEILRDKFSLMNENRELKVRVAAQN 493
Query: 185 EKEQQLVNDCVKELRDANVQIASISE---ELAKKTEDAARQQEEITHLLSQIVDLQKKAK 241
E+ ++ C +E+ + V++ S+ + +L K E + + +S + + +
Sbjct: 494 ER----LDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCI 549
Query: 242 ACAVENEELVQHLG---AAKDAQ-RQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTM 297
C N+ ++ L A K+A+ ++L A L ++ ++ + +++QE K +T
Sbjct: 550 GCCEANKLVISELRIKLAIKEAEIQKLHANL--TANQLSQSLITCNDSQESSKLSSLETE 607
Query: 298 P 298
P
Sbjct: 608 P 608
Score = 40.4 bits (93), Expect = 0.005
Identities = 63/327 (19%), Positives = 131/327 (40%), Gaps = 62/327 (18%)
Query: 14 EYDCQDEERKPTHRQHDTQDLLEEVL-----CAERVGQMTKTYNDIDAVTRLLEEK---- 64
E + D + HR Q + EE+L ++ +MTK + + + + LEEK
Sbjct: 654 EAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAY 713
Query: 65 ERDLELAARIGQSLLKKNKTL--------TERNELLE----------EQVEHIREEVSQL 106
A + Q L++KN+ + TE ++ EQ + + +++ +L
Sbjct: 714 SSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERL 773
Query: 107 RHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLK----DL 162
+L KD+ + + + +C HL+SL + L ++
Sbjct: 774 EAQLEKKDQQFKEQEKTMSMLQQDIIC--------------KQHHLESLDRLLTESKGEM 819
Query: 163 EEENV----VLRSEASQLKTETITYEEKEQQL---VNDCVKELRDANVQIASISEELAKK 215
++EN+ L++ +Q+ ETI + + L + V L ++L KK
Sbjct: 820 KKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKK 879
Query: 216 TEDAARQQEEI---THLLSQIVDLQKKAKACAVENEELVQ----HLGAAKDAQRQLTAEL 268
+E+ Q+E+ H L + + + + ++++Q G +D Q +L ++
Sbjct: 880 SEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQV 939
Query: 269 RELEDKYAECMEMLHEAQEELKNLRNK 295
+LE E + + E+L+ + K
Sbjct: 940 SKLEQ---ELQKQRESSAEKLRKMEEK 963
Score = 33.9 bits (76), Expect = 0.51
Identities = 49/225 (21%), Positives = 98/225 (43%), Gaps = 28/225 (12%)
Query: 119 FYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKT 178
F +SA + E +S+ K + ++ + H SL K + + E R++ S L++
Sbjct: 221 FSSSAPVDQEIKSLREKLNKLRQQNACLVTQNH--SLMTKFESIHFELTQSRAKVSMLES 278
Query: 179 ---ETITYEEKEQQLVNDCV------KELRDANVQIASISEELAKKTEDAARQQEEITHL 229
+ + E+Q++N K LR+A ++ + + +K + +EE L
Sbjct: 279 AQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKL 338
Query: 230 LSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEEL 289
+++ K+ K + E + + +L+ ++ + K AE +E + +A+EE+
Sbjct: 339 KVDLLEQTKQGKRAERQRNEALYN-------AEELSKAFQQYKKKVAEKLEKV-QAEEEI 390
Query: 290 --KNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEE 332
+NL N N R GL+ +E+E K QL+E
Sbjct: 391 LERNLTNCEKEN--KRLQERCGLY-----KSELEILKEKLRQLKE 428
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 66.6 bits (161), Expect = 7e-11
Identities = 61/289 (21%), Positives = 124/289 (42%), Gaps = 33/289 (11%)
Query: 26 HRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTL 85
H + T D ++L ++ + K+ + LE + LE + Q L ++ KT+
Sbjct: 944 HDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEAR---LEESTNYNQQLRQELKTV 1000
Query: 86 TERNELLEEQVEHIR-----------------EEVSQLRHELSMKDELLQFYTSAAEESE 128
+ E L+++ + R E R L +KD L++ + A
Sbjct: 1001 KKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQA 1060
Query: 129 PESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQ 188
+ T LK+ E+ ++ + +LQ++ L+E+N L+++ ++L+ E T +
Sbjct: 1061 EKQALKTQLKQLETQNN-NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQST 1119
Query: 189 QLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKAC----A 244
L+N N Q+ L + E +++E++ L ++ +K + A
Sbjct: 1120 SLMNQ--------NAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQA 1171
Query: 245 VENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLR 293
E E L+ G K A + L E R+LED+Y + ++ + ++ K L+
Sbjct: 1172 SEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1220
Score = 57.8 bits (138), Expect = 3e-08
Identities = 86/368 (23%), Positives = 165/368 (44%), Gaps = 43/368 (11%)
Query: 3 LRDKGGEEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKT--YNDIDAVTRL 60
+++K E+ E ++ ER+ + + + L + V + Q++ DI+ ++
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591
Query: 61 LEEKERD-------LELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELS-M 112
L E ++ +E R + L+ K ER E LE ++ H+ +E L+ +++ +
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 113 KDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSE 172
K + E SE E K +S ++ F L+SL+K+ L+EEN+ LR
Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLT--FQLESLEKENSQLDEENLELRRN 709
Query: 173 ASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELA---KKTE-----------D 218
LK ++ + + QL N KEL Q+ E L KKTE +
Sbjct: 710 VESLKCASM--KMAQLQLEN---KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIE 764
Query: 219 AARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQR---QLTAELRELEDKY 275
R Q+ + + +I L+ + + +EN+ L ++L K + + QL E + LE +
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET 824
Query: 276 AECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMD----SLAAEI----EGTMR-K 326
++ + + ++E K LR + T+ +++ + ++ +L+ EI E +R K
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
Query: 327 ELQLEEAE 334
EL+ E E
Sbjct: 885 ELEKENKE 892
Score = 53.9 bits (128), Expect = 5e-07
Identities = 81/397 (20%), Positives = 179/397 (45%), Gaps = 51/397 (12%)
Query: 42 ERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIRE 101
+++ Q+ D++ + L++ +L+++++ + L K+NK+L + LE+ + + +
Sbjct: 777 KKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEK 836
Query: 102 EVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKD 161
E +LR + +KD L E +V L++ + S + + +S +LK+
Sbjct: 837 ENKRLRQQAEIKDTTL----------EENNVKIGNLEKENKTLSKEIGIYKESC-VRLKE 885
Query: 162 LEEENVVLRSEAS-QLKT-----ETITYEEKEQQLVNDCVKELRDANVQIASISEEL--- 212
LE+EN L A+ +KT E + E+ + Q +N+ +++L +I E L
Sbjct: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD 945
Query: 213 AKKTEDAARQ--QEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRE 270
+ T+D+ + + ++ L + +++ K+ K A+E L + + +QL EL+
Sbjct: 946 EQSTDDSRYKLLESKLESTLKKSLEI-KEEKIAALE-----ARLEESTNYNQQLRQELKT 999
Query: 271 LEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYH------SLGLFPMDSLAAEIE--- 321
++ Y E L + Q+E + +++ + ++ + L + E+E
Sbjct: 1000 VKKNY----EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1055
Query: 322 GTMRKE-----LQLEEAESPDITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSAM 376
T++ E QL++ E+ + Q ++ R + +Q + T N ++S +
Sbjct: 1056 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNT-TLQTQNAKLQVENSTL 1114
Query: 377 NSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETE 413
NS +S ++ I L+N+ S+I E E
Sbjct: 1115 NSQSTSLMNQNAQLL----IQQSSLENENESVIKERE 1147
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/255 (20%), Positives = 114/255 (44%), Gaps = 19/255 (7%)
Query: 62 EEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQ--- 118
+E+ D+E + L + N+ L E +LE+Q+E R +L HEL ++ L+
Sbjct: 333 KERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL-HELEKENLQLKAKL 391
Query: 119 --------FYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLR 170
EE E++ ++ S+ + L+ + + + E L
Sbjct: 392 HDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451
Query: 171 SEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLL 230
E ++L + + E E Q + V+ELR + + ++ K ++ R +++ L
Sbjct: 452 HEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
Query: 231 SQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAE-LRELEDKYAECMEMLHE-AQEE 288
++IV ++ + C +++L++ + AQ + T E LRE ++ + +E +E +
Sbjct: 512 NEIVQEKQSLQNCQNLSKDLMK-----EKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 289 LKNLRNKTMPNTTSR 303
+ +LR ++ + +R
Sbjct: 567 VSSLRQRSQISAEAR 581
Score = 49.3 bits (116), Expect = 1e-05
Identities = 90/392 (22%), Positives = 160/392 (40%), Gaps = 50/392 (12%)
Query: 37 EVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQV 96
E+L E V + N + L++EK + + + ++ ++ K L + NE L + V
Sbjct: 508 EILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTV 567
Query: 97 EHIREEVSQLRHELSMKD---ELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNY---- 149
+R+ SQ+ E +KD E + S E S + ++ + +++Y
Sbjct: 568 SSLRQR-SQISAEARVKDIEKENKILHESIKETS--SKLSKIEFEKRQIKKELEHYKEKG 624
Query: 150 FHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASIS 209
+ L+ +L LE+EN +L+ + + LK E EQ+ +
Sbjct: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE-------------------N 665
Query: 210 EELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEEL---VQHLGAAKDAQRQLTA 266
EL ++ + + +L Q+ L+K+ EN EL V+ L A QL
Sbjct: 666 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725
Query: 267 ELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRK 326
E +ELE + E L + E LK KT S Y L + L +E + +K
Sbjct: 726 ENKELESE----KEQLKKGLELLKASFKKTERLEVS--YQGLDI-ENQRLQKTLENSNKK 778
Query: 327 ----ELQLEEAESPDITHQKRVFE---TVRNINQVVKQ-RSLTPSPMNI-PGSNQSSAMN 377
E +L++ E + T QK + E + + + Q+ K+ +SL + Q N
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Query: 378 SLLSSCVSTPRSSFYGSD--IGNVVLDNKTNS 407
L ++ ++ IGN+ +NKT S
Sbjct: 839 KRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870
Score = 40.8 bits (94), Expect = 0.004
Identities = 79/329 (24%), Positives = 131/329 (39%), Gaps = 82/329 (24%)
Query: 79 LKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTP-L 137
L KN L L++E+ EH S+ ELS + + L F A+ S +S C +P +
Sbjct: 189 LLKNMAL-HLKRLIDERDEH-----SETIIELSEERDGLHFLPHAS--SSAQSPCGSPGM 240
Query: 138 KRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKE 197
KR ES + L + K++ L +E EEK +QL+ DC +E
Sbjct: 241 KRTESRQHLS--VELADAKAKIRRLRQE-----------------LEEKTEQLL-DCKQE 280
Query: 198 LRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAA 257
L +++ R Q+E +LLS A++ + +EL
Sbjct: 281 LEQMEIELK--------------RLQQENMNLLSD-------ARSARMYRDEL------- 312
Query: 258 KDAQRQLTAELRELEDKYAECMEMLHEAQ------EELKN-----LRNKTM-------PN 299
DA R+ + +LE + + E LH+ + EELK L KTM
Sbjct: 313 -DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTR 371
Query: 300 TTSRRYHSLGLFPMDSLAAEIEGTMRKEL---QLEEAESPDIT---HQKRVFETVRNINQ 353
S + H L + A + M +++ ++EE ++T QK+ + ++
Sbjct: 372 ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGW 431
Query: 354 VVKQRSLTPSPMNIPGSNQSSAMNSLLSS 382
++Q S T P + +N L SS
Sbjct: 432 ELEQISRTSELSEAPQKSLGHEVNELTSS 460
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 66.2 bits (160), Expect = 9e-11
Identities = 72/362 (19%), Positives = 160/362 (44%), Gaps = 49/362 (13%)
Query: 25 THRQHDTQDLLEEVL-CAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNK 83
T + TQ+L E+ ER+ +M + ++ L+ ER+ L Q L++ K
Sbjct: 866 TELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVK 925
Query: 84 TLTERNELLEEQVEHIREEVSQLRHEL----SMKDELLQFYTSAAEESEPESVCSTPLKR 139
TLT+ + L++ E ++ E QL+ ++ +M + + +A E + LK
Sbjct: 926 TLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLK- 984
Query: 140 NESSSSVQNYFHLDSLQKKLKDLEEENVV---LRSEASQLKTETITYEEKEQQLVNDCVK 196
++ S V H++ + KD ++ +V + + T+T+T + K+ +++
Sbjct: 985 SKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII----- 1039
Query: 197 ELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGA 256
E + + EL + E ++E++ L + +++ +EN+E ++ LG
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM-------TIENQEELRLLGD 1092
Query: 257 AKDAQRQLTAE------------------LRELEDKYAECMEMLHEAQEELKNLRNKTMP 298
Q+++ A+ L E+E+K E + L E Q++L N++ +
Sbjct: 1093 ELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEM-- 1150
Query: 299 NTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQR 358
+ ++ + + ++L E++ KEL LE E+ + +++ E + + K+R
Sbjct: 1151 SEMQKKINEI-----ENLKNELK---NKELTLEHMETERLELAQKLNENYEEVKSITKER 1202
Query: 359 SL 360
+
Sbjct: 1203 KV 1204
Score = 63.2 bits (152), Expect = 8e-10
Identities = 76/338 (22%), Positives = 147/338 (43%), Gaps = 55/338 (16%)
Query: 3 LRDKGGEEECFEYDCQDEERKPTHRQ------HDTQDLLEEVLCAERVGQMTKTYNDIDA 56
LR E+ + QD E+ T Q H+ Q+LL V + V + +T N+++
Sbjct: 1254 LRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV---KEVSETQETMNELEL 1310
Query: 57 VTRLLEEKERDLELAARIGQSLLKKN--------------------KTLTERNELLEEQV 96
+T + +D ARI L+ N KT+ E E+ +Q+
Sbjct: 1311 LTE--QSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQL 1368
Query: 97 -EHIREEVSQLRHELSMKDELLQFY------TSAAEESEPESVCSTPLKRNE------SS 143
EHIRE +++++ S +++ L T E E + L R E S
Sbjct: 1369 KEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSK 1428
Query: 144 SSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKT---ETITYE---EKEQQLVNDCVKE 197
+++ + S+ K+ DL+ VL+SE+ QLK E + E+E ++ + C+KE
Sbjct: 1429 RLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKE 1488
Query: 198 ----LRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAV-ENEELVQ 252
+ + V ++ E++ + +++ + + +I + +++ + E +E V
Sbjct: 1489 QEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVN 1548
Query: 253 HLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELK 290
L K+ ++ + L+ +E K E L E+QEE++
Sbjct: 1549 ELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ 1586
Score = 52.8 bits (125), Expect = 1e-06
Identities = 67/311 (21%), Positives = 141/311 (45%), Gaps = 45/311 (14%)
Query: 64 KERDLELAARIGQSLLKKNKTL--TERNELLEE--QVEHIREEVSQLRHELSMKDELLQF 119
KE E+ A++ +S K+ + L T NE E+ ++EH++E+ + L
Sbjct: 1610 KENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNL--------- 1660
Query: 120 YTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKT- 178
E E E++ T + +N + S+ K+ DL L+ E QLK
Sbjct: 1661 -----ENIETENIRLTQILH-------ENLEEMRSVTKERDDLRSVEETLKVERDQLKEN 1708
Query: 179 --ETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITH----LLSQ 232
ETIT + ++Q+ + L++ I + +++KT + + Q+++ H L +Q
Sbjct: 1709 LRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQ 1768
Query: 233 IVDLQKKAKACAV---ENEELVQHL-GAAKDAQRQLTAELRELEDKYAECMEMLHEAQ-E 287
+ +Q++ + + E +E + L G + +L+ ++LE+ A+ E + E +
Sbjct: 1769 DLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKAN 1828
Query: 288 ELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFET 347
E + + K N T ++ + M+ L +I+ + L L + E ++ +++ E
Sbjct: 1829 EHQLITLKKDVNETQKK-----VSEMEQLKKQIKD---QSLTLSKLEIENLNLAQKLHEN 1880
Query: 348 VRNINQVVKQR 358
+ + V+K+R
Sbjct: 1881 LEEMKSVMKER 1891
Score = 50.4 bits (119), Expect = 5e-06
Identities = 74/363 (20%), Positives = 151/363 (41%), Gaps = 34/363 (9%)
Query: 20 EERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLL 79
+E K ++ D L+EVL +E Q+ + +I A K + E ++ L
Sbjct: 1435 DEMKSVAKEKDDLQRLQEVLQSES-DQLKENIKEIVA-------KHLETEEELKVAHCCL 1486
Query: 80 KKNK-TLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLK 138
K+ + T+ E L E+ E+S ++ +L ++ LQ E E + +
Sbjct: 1487 KEQEETINELRVNLSEK----ETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISE 1542
Query: 139 RNESSSSVQNYF-HLDSLQKKLKDLEEENVVL--RSEASQLKTETITYEEKEQQLVNDCV 195
E + ++ + H + L+ +E + + L R + SQ + + + E++E + V + +
Sbjct: 1543 VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEAL 1602
Query: 196 KELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLG 255
+ RD Q+ ++E+ K +++ QE+ L + + K C +E HL
Sbjct: 1603 QIERD---QLKENTKEIVAKMKES---QEKEYQFLKMTAVNETQEKMCEIE------HLK 1650
Query: 256 AAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDS 315
+ Q+ L +E + ++LHE EE +R+ T R D
Sbjct: 1651 EQFETQK---LNLENIETENIRLTQILHENLEE---MRSVTKERDDLRSVEETLKVERDQ 1704
Query: 316 LAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSA 375
L + T+ ++L+ +E H K ET+ + +V +++ S M + + A
Sbjct: 1705 LKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDA 1764
Query: 376 MNS 378
+ +
Sbjct: 1765 LKA 1767
Score = 49.7 bits (117), Expect = 9e-06
Identities = 64/283 (22%), Positives = 127/283 (44%), Gaps = 47/283 (16%)
Query: 36 EEVLCAERVGQMTKTY----NDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNEL 91
E + E++ ++ TY NDI LE K++ + + + L +T+ L
Sbjct: 647 ENLELKEKMKELATTYKQMENDIQLYQSQLEAKKK---MQVDLEKELQSAFNEITKLTSL 703
Query: 92 LEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEP---ESVCSTPLKRNESSSSVQN 148
++ +V ++ + L E + D L + EE+E E + + LK S
Sbjct: 704 IDGKVP--KDLLCNLELEGKITD-LQKELNKEVEENEALREEVILLSELKSLPSE----- 755
Query: 149 YFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASI 208
++ L+K+++D EE ++ SE +L +E + E + Q L+ + I
Sbjct: 756 ---VERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEE-----------IGKT 801
Query: 209 SEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHL-GAAKDAQR----- 262
++LA + +E + + +D ++K K ENE + Q + +K+AQ+
Sbjct: 802 KDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSL 861
Query: 263 -----QLTAELRELEDKYAECMEMLHEAQ---EELKNLRNKTM 297
+L+ + +EL++K E E L+E + E+L+N R+ T+
Sbjct: 862 GALKTELSYKTQELQEKTREVQERLNEMEQLKEQLEN-RDSTL 903
Score = 44.7 bits (104), Expect = 3e-04
Identities = 56/279 (20%), Positives = 119/279 (42%), Gaps = 23/279 (8%)
Query: 42 ERVGQMTKTYNDIDAVTRLLEEKE-RDLELAARIGQSLLKKNKTLTERNEL--LEEQVEH 98
++V +M + I + L + E +L LA ++ ++L + + ER+ L +EE ++
Sbjct: 1844 KKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKL 1903
Query: 99 IREEVSQLRHELSMKD-ELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYF------- 150
R+++ + E +D E+ Q +A S+ L+ S ++Q
Sbjct: 1904 ERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDK 1963
Query: 151 HLDSLQKKLKDLEEENVVLRS-----EASQLKTETITYEEKEQQLVNDCVKELRDANVQI 205
D LQKK+++L+++ + L S K + +K+ + N ++ +R N Q+
Sbjct: 1964 SKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQL 2023
Query: 206 ASISEE-------LAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAK 258
E +AK+ ++ R +E + Q + ++ A +N ++
Sbjct: 2024 TKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLS 2083
Query: 259 DAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTM 297
D Q+ LT LRE + E ++ E + + L ++
Sbjct: 2084 DGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSL 2122
Score = 40.0 bits (92), Expect = 0.007
Identities = 70/353 (19%), Positives = 148/353 (41%), Gaps = 43/353 (12%)
Query: 7 GGEEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKER 66
G ++ F+ ++K +TQ L +V E + Q K ++ L++EK
Sbjct: 1002 GETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS-------LIQEKN- 1053
Query: 67 DLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAA-- 124
EL + + +K + T+ E +E +E+ +EE+ L EL + E++ + A
Sbjct: 1054 --ELQQMLESVIAEKEQLKTDLKENIEMTIEN-QEELRLLGDELKKQQEIVAQEKNHAIK 1110
Query: 125 EESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYE 184
+E E C + E L ++L++ +++ + ++ E S+++ + E
Sbjct: 1111 KEGELSRTCDRLAEVEEK---------LKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE 1161
Query: 185 EKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACA 244
+ +L N KEL +++ + ELA+K + EE+ + + L++ K+
Sbjct: 1162 NLKNELKN---KELTLEHMETERL--ELAQKLNE---NYEEVKSITKERKVLKELQKSFE 1213
Query: 245 VENEELVQHLGAAKDAQRQLTAE-------LRELEDKYAECMEMLHEAQEELKNLRNKTM 297
E + L ++ + Q E L+E ++ E + E ++ N ++
Sbjct: 1214 TERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEK 1273
Query: 298 PNTTSRR-----YHSLGLFPMDSLAAEIEGTMRK-ELQLEEAESPDITHQKRV 344
+T + + L P +E + TM + EL E++ + D T R+
Sbjct: 1274 SHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARI 1326
Score = 39.3 bits (90), Expect = 0.012
Identities = 68/295 (23%), Positives = 119/295 (40%), Gaps = 47/295 (15%)
Query: 49 KTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRH 108
K ND+D L + ++D E+ S LK L + E+ + +E+ +L
Sbjct: 529 KEKNDLDEFEALERKTKKDQEMQLIHEISNLKN---LVKHAEVYNQDLENELSSKVELLR 585
Query: 109 ELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSV-QNYFHLDSLQKKLKDLEEENV 167
E + + LQ Y + + + S L+ E + Q F +++ D + E+
Sbjct: 586 EKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVAL---DAKRESA 642
Query: 168 VLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEIT 227
LRSE +LK + +Q+ ND +Q+ E KK +
Sbjct: 643 FLRSENLELKEKMKELATTYKQMEND---------IQLYQSQLEAKKKMQ---------- 683
Query: 228 HLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQE 287
VDL+K+ ++ E +L + + L L ELE K + + L++ E
Sbjct: 684 ------VDLEKELQSAFNEITKLTSLIDG--KVPKDLLCNL-ELEGKITDLQKELNKEVE 734
Query: 288 ELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQK 342
E + LR + + L + SL +E+E +RKE+Q + E IT +K
Sbjct: 735 ENEALREEV-----------ILLSELKSLPSEVE-RLRKEIQDKSEELHIITSEK 777
Score = 30.8 bits (68), Expect = 4.4
Identities = 64/285 (22%), Positives = 125/285 (43%), Gaps = 49/285 (17%)
Query: 9 EEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDL 68
EE E Q E+ + + +DLL++V E++ +T+ ++T ++E
Sbjct: 360 EEVSLETRAQAMEKDQLAQLLEEKDLLQKVQ-NEKIENLTRMLVTSSSLTL---QQELKA 415
Query: 69 ELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESE 128
+ R+ L K NK +N +Q +I ++ H+LS+ + L + S ES+
Sbjct: 416 KRKRRVTWCLGKINKM---KNSNYADQF-NIPTNITTKTHKLSI-NLLREIDESVCSESD 470
Query: 129 PESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQ 188
S L E + + + + ++++ +L L + L + QL+TE EE E
Sbjct: 471 VFSNTLDTLSEIEWNPATK-LLNQENIESELNSLRADYDNLVLDYEQLRTEK---EEMEL 526
Query: 189 QLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENE 248
+L KE D + E L +KT+ Q+ ++ H +S + +L K A+ V N+
Sbjct: 527 KL-----KEKNDLDE-----FEALERKTKKD--QEMQLIHEISNLKNLVKHAE---VYNQ 571
Query: 249 ELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLR 293
+L E++ + +E+L E ++++K L+
Sbjct: 572 DL---------------------ENELSSKVELLREKEDQIKKLQ 595
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 65.9 bits (159), Expect = 1e-10
Identities = 55/250 (22%), Positives = 109/250 (43%), Gaps = 30/250 (12%)
Query: 65 ERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIR-----------------EEVSQLR 107
E LE + Q L ++ KT+ + E L+++ + R E R
Sbjct: 979 EARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTR 1038
Query: 108 HELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENV 167
L +KD L++ + A + T LK+ E+ ++ + +LQ++ L+E+N
Sbjct: 1039 ELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN-NLQAQILALQRQTVSLQEQNT 1097
Query: 168 VLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEIT 227
L+++ ++L+ E T + L+N N Q+ L + E +++E++
Sbjct: 1098 TLQTQNAKLQVENSTLNSQSTSLMNQ--------NAQLLIQQSSLENENESVIKEREDLK 1149
Query: 228 HLLSQIVDLQKKAKAC----AVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLH 283
L ++ +K + A E E L+ G K A + L E R+LED+Y + ++
Sbjct: 1150 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1209
Query: 284 EAQEELKNLR 293
+ ++ K L+
Sbjct: 1210 QLEDLEKMLK 1219
Score = 57.8 bits (138), Expect = 3e-08
Identities = 86/368 (23%), Positives = 165/368 (44%), Gaps = 43/368 (11%)
Query: 3 LRDKGGEEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKT--YNDIDAVTRL 60
+++K E+ E ++ ER+ + + + L + V + Q++ DI+ ++
Sbjct: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKI 591
Query: 61 LEEKERD-------LELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELS-M 112
L E ++ +E R + L+ K ER E LE ++ H+ +E L+ +++ +
Sbjct: 592 LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL 651
Query: 113 KDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSE 172
K + E SE E K +S ++ F L+SL+K+ L+EEN+ LR
Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLT--FQLESLEKENSQLDEENLELRRN 709
Query: 173 ASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELA---KKTE-----------D 218
LK ++ + + QL N KEL Q+ E L KKTE +
Sbjct: 710 VESLKCASM--KMAQLQLEN---KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIE 764
Query: 219 AARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQR---QLTAELRELEDKY 275
R Q+ + + +I L+ + + +EN+ L ++L K + + QL E + LE +
Sbjct: 765 NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET 824
Query: 276 AECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMD----SLAAEI----EGTMR-K 326
++ + + ++E K LR + T+ +++ + ++ +L+ EI E +R K
Sbjct: 825 SQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
Query: 327 ELQLEEAE 334
EL+ E E
Sbjct: 885 ELEKENKE 892
Score = 54.3 bits (129), Expect = 4e-07
Identities = 79/394 (20%), Positives = 167/394 (42%), Gaps = 46/394 (11%)
Query: 42 ERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIRE 101
+++ Q+ D++ + L++ +L+++++ + L K+NK+L + LE+ + + +
Sbjct: 777 KKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEK 836
Query: 102 EVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKD 161
E +LR + +KD L E +V L++ + S + + +S +LK+
Sbjct: 837 ENKRLRQQAEIKDTTL----------EENNVKIGNLEKENKTLSKEIGIYKESC-VRLKE 885
Query: 162 LEEENVVLRSEAS-------QLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAK 214
LE+EN L A+ L+ + ++ + K QQ+ ND L ++ I +
Sbjct: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND----LEKLTHELEKIGLNKER 941
Query: 215 KTEDAARQQEEITHLLSQIVDLQKKAKACAVEN-EELVQHLGAAKDAQRQLTAELRELED 273
D + L S++ KK+ E L L + + +QL EL+ ++
Sbjct: 942 LLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKK 1001
Query: 274 KYAECMEMLHEAQEELKNLRNKTMPNTTSRRYH------SLGLFPMDSLAAEIE---GTM 324
Y E L + Q+E + +++ + ++ + L + E+E T+
Sbjct: 1002 NY----EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1057
Query: 325 RKE-----LQLEEAESPDITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSAMNSL 379
+ E QL++ E+ + Q ++ R + +Q + T N ++S +NS
Sbjct: 1058 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNT-TLQTQNAKLQVENSTLNSQ 1116
Query: 380 LSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETE 413
+S ++ I L+N+ S+I E E
Sbjct: 1117 STSLMNQNAQLL----IQQSSLENENESVIKERE 1146
Score = 49.3 bits (116), Expect = 1e-05
Identities = 52/255 (20%), Positives = 114/255 (44%), Gaps = 19/255 (7%)
Query: 62 EEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQ--- 118
+E+ D+E + L + N+ L E +LE+Q+E R +L HEL ++ L+
Sbjct: 333 KERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL-HELEKENLQLKAKL 391
Query: 119 --------FYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLR 170
EE E++ ++ S+ + L+ + + + E L
Sbjct: 392 HDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451
Query: 171 SEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLL 230
E ++L + + E E Q + V+ELR + + ++ K ++ R +++ L
Sbjct: 452 HEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
Query: 231 SQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAE-LRELEDKYAECMEMLHE-AQEE 288
++IV ++ + C +++L++ + AQ + T E LRE ++ + +E +E +
Sbjct: 512 NEIVQEKQSLQNCQNLSKDLMK-----EKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 289 LKNLRNKTMPNTTSR 303
+ +LR ++ + +R
Sbjct: 567 VSSLRQRSQISAEAR 581
Score = 49.3 bits (116), Expect = 1e-05
Identities = 90/392 (22%), Positives = 160/392 (40%), Gaps = 50/392 (12%)
Query: 37 EVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQV 96
E+L E V + N + L++EK + + + ++ ++ K L + NE L + V
Sbjct: 508 EILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTV 567
Query: 97 EHIREEVSQLRHELSMKD---ELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNY---- 149
+R+ SQ+ E +KD E + S E S + ++ + +++Y
Sbjct: 568 SSLRQR-SQISAEARVKDIEKENKILHESIKETS--SKLSKIEFEKRQIKKELEHYKEKG 624
Query: 150 FHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASIS 209
+ L+ +L LE+EN +L+ + + LK E EQ+ +
Sbjct: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE-------------------N 665
Query: 210 EELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEEL---VQHLGAAKDAQRQLTA 266
EL ++ + + +L Q+ L+K+ EN EL V+ L A QL
Sbjct: 666 SELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725
Query: 267 ELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRK 326
E +ELE + E L + E LK KT S Y L + L +E + +K
Sbjct: 726 ENKELESE----KEQLKKGLELLKASFKKTERLEVS--YQGLDI-ENQRLQKTLENSNKK 778
Query: 327 ----ELQLEEAESPDITHQKRVFE---TVRNINQVVKQ-RSLTPSPMNI-PGSNQSSAMN 377
E +L++ E + T QK + E + + + Q+ K+ +SL + Q N
Sbjct: 779 IQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Query: 378 SLLSSCVSTPRSSFYGSD--IGNVVLDNKTNS 407
L ++ ++ IGN+ +NKT S
Sbjct: 839 KRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870
Score = 40.8 bits (94), Expect = 0.004
Identities = 79/329 (24%), Positives = 131/329 (39%), Gaps = 82/329 (24%)
Query: 79 LKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTP-L 137
L KN L L++E+ EH S+ ELS + + L F A+ S +S C +P +
Sbjct: 189 LLKNMAL-HLKRLIDERDEH-----SETIIELSEERDGLHFLPHAS--SSAQSPCGSPGM 240
Query: 138 KRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKE 197
KR ES + L + K++ L +E EEK +QL+ DC +E
Sbjct: 241 KRTESRQHLS--VELADAKAKIRRLRQE-----------------LEEKTEQLL-DCKQE 280
Query: 198 LRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAA 257
L +++ R Q+E +LLS A++ + +EL
Sbjct: 281 LEQMEIELK--------------RLQQENMNLLSD-------ARSARMYRDEL------- 312
Query: 258 KDAQRQLTAELRELEDKYAECMEMLHEAQ------EELKN-----LRNKTM-------PN 299
DA R+ + +LE + + E LH+ + EELK L KTM
Sbjct: 313 -DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTR 371
Query: 300 TTSRRYHSLGLFPMDSLAAEIEGTMRKEL---QLEEAESPDIT---HQKRVFETVRNINQ 353
S + H L + A + M +++ ++EE ++T QK+ + ++
Sbjct: 372 ARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGW 431
Query: 354 VVKQRSLTPSPMNIPGSNQSSAMNSLLSS 382
++Q S T P + +N L SS
Sbjct: 432 ELEQISRTSELSEAPQKSLGHEVNELTSS 460
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 65.1 bits (157), Expect = 2e-10
Identities = 75/272 (27%), Positives = 121/272 (44%), Gaps = 42/272 (15%)
Query: 30 DTQDLLEEVLCAERVGQMT----KTYNDIDAVTRLLEEKE---RDLELA-ARIGQSLLKK 81
D + + ++++ AER Q + + ++ D + RL EKE R+LE A++ L ++
Sbjct: 965 DKELMAQKLVQAEREAQASLREQRAAHEED-LQRLQREKEAAWRELEAERAQLQSQLQRE 1023
Query: 82 NKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNE 141
+ L R LE + E + EE++ L+ E +DE L ESE + S LK +E
Sbjct: 1024 QEELLAR---LEAEKEELSEEIAALQQE---RDEGLLL-----AESEKQQALS--LKESE 1070
Query: 142 SSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDA 201
++ L +KL + E + K + + +E+++ VN ELRD
Sbjct: 1071 KTA----------LSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDL 1120
Query: 202 NVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQ 261
Q + E AA +E+ L Q DL K+ +C E EEL L +DA+
Sbjct: 1121 RAQ----------REEAAAAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDAR 1170
Query: 262 RQLTAELRELEDKYAECMEMLHEAQEELKNLR 293
L EL E + K E E ++E LR
Sbjct: 1171 DGLRRELLEAQRKLRESQEGREVQRQEAGELR 1202
Score = 52.8 bits (125), Expect = 1e-06
Identities = 99/442 (22%), Positives = 173/442 (39%), Gaps = 43/442 (9%)
Query: 57 VTRLLEEKERDLELAARIGQSLLKKNKTLTER-NELLEEQVEHIREEVSQLRHELSMKDE 115
V R +E+ +L L + + L+ + + E+ E LE+Q+ +R E SQL+ +L+
Sbjct: 782 VAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSR 841
Query: 116 LLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQ 175
L E++ E+ + L +L E E L EA++
Sbjct: 842 QLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATR 901
Query: 176 LKTETITYE----EKEQQLVN-DCVKELRDANVQIASISEELAKKTEDAARQQEEITH-- 228
L+ E E E ++QL + +E +A Q +++E RQQ T
Sbjct: 902 LRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEK 961
Query: 229 -------LLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEM 281
+ ++V +++A+A E+ H + QR+ A RELE + A+
Sbjct: 962 ASLDKELMAQKLVQAEREAQASL--REQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQ 1019
Query: 282 LHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQ 341
L QEEL R + S +L + L E ++ L L+E+E ++
Sbjct: 1020 LQREQEELL-ARLEAEKEELSEEIAALQQERDEGLLL-AESEKQQALSLKESEKTALS-- 1075
Query: 342 KRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSC--VSTPRSSFYGSDIGNV 399
+++ T ++ + + S +N+L S + R + V
Sbjct: 1076 EKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEV 1135
Query: 400 VLDNKTNSIILETEAADLGNDERSKKPGTPGTPGSHDLETALRRL-----SLRRENYLSE 454
L+ +A DLG S + +L T LR L LRRE ++
Sbjct: 1136 RR--------LQEQARDLGKQRDS------CLREAEELRTQLRLLEDARDGLRRELLEAQ 1181
Query: 455 RRFFEEEQERKLQELAEKGELR 476
R+ E ++ R++Q E GELR
Sbjct: 1182 RKLRESQEGREVQR-QEAGELR 1202
Score = 42.7 bits (99), Expect = 0.001
Identities = 67/317 (21%), Positives = 127/317 (40%), Gaps = 40/317 (12%)
Query: 20 EERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLL 79
E++ PT R H+ L E++ R Q++ +++ R + + LE AAR ++L
Sbjct: 819 EQQLPTLR-HERSQLQEQLAQLSR--QLSGREQELEQARREAQRQVEALERAAREKEALA 875
Query: 80 KKNKTLTERNELLEEQVEHIREEVSQLRHEL-SMKDELLQFYTSAAEESEPESVCSTPLK 138
K++ L + E + + EE ++LR E +++ L + A+ +
Sbjct: 876 KEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQ---------LEAR 926
Query: 139 RNESSSSVQNYFHL-DSLQKKLKDLEEENVVLRSEAS---QLKTETITYEEKEQQLVNDC 194
R + + Q ++L +L L ++ + + +AS +L + + E+E Q
Sbjct: 927 REQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQKLVQAEREAQ----- 981
Query: 195 VKELRDANVQIASISEELAKKTEDAARQQEEIT----HLLSQIVDLQKKAKACAVENEEL 250
AS+ E+ A ED R Q E L ++ LQ + + E EEL
Sbjct: 982 -----------ASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQR---EQEEL 1027
Query: 251 VQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGL 310
+ L A K+ + A L++ D+ E + LK + HSL
Sbjct: 1028 LARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEKLMGTRHSLAT 1087
Query: 311 FPMDSLAAEIEGTMRKE 327
++ + + R+E
Sbjct: 1088 ISLEMERQKRDAQSRQE 1104
Score = 42.4 bits (98), Expect = 0.001
Identities = 65/320 (20%), Positives = 134/320 (41%), Gaps = 31/320 (9%)
Query: 50 TYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHE 109
T + + ++ +E ++RD + +R Q N +E +L ++ E ++R
Sbjct: 1081 TRHSLATISLEMERQKRDAQ--SRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEVRRL 1138
Query: 110 LSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVL 169
+L + S E+E T L+ E + L++ Q+KL++ +E V
Sbjct: 1139 QEQARDLGKQRDSCLREAEE---LRTQLRLLEDARDGLRRELLEA-QRKLRESQEGREVQ 1194
Query: 170 RSEASQLKTETITYEEKEQQLVNDCVKELRDA---------NVQIASISEE--LAKKTED 218
R EA +L+ ++ KE++ + +ELR A ++++A+ +E LA E
Sbjct: 1195 RQEAGELR-RSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEA 1253
Query: 219 AARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAEC 278
+E L + + ++++ E +EL + + +L EL EL+ + A
Sbjct: 1254 RTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALG 1313
Query: 279 MEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDI 338
E++ E LR + + S ++ + E++ RK L+E E
Sbjct: 1314 ERAEKESRRETLGLRQRLLKGEAS----------LEVMRQELQVAQRK---LQEQEGEFR 1360
Query: 339 THQKRVFETVRNINQVVKQR 358
T ++R+ ++ KQ+
Sbjct: 1361 TRERRLLGSLEEARGTEKQQ 1380
Score = 36.6 bits (83), Expect = 0.079
Identities = 57/247 (23%), Positives = 93/247 (37%), Gaps = 26/247 (10%)
Query: 102 EVSQLRHELSMKDELLQFYTSAAEESEPES-VCSTPLKRNESSSSVQNYFHLDSLQKKLK 160
+V +R +LL +SE E L+R + H D+ Q++++
Sbjct: 534 QVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDA-QREVQ 592
Query: 161 DLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKK----- 215
L N +L E S L Q+ +ELR ++ + EEL ++
Sbjct: 593 RLRSANELLSREKSNLAHSL--------QVAQQQAEELRQEREKLQAAQEELRRQRDRLE 644
Query: 216 ------TEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELR 269
+D AR + E+ Q+ L+ K A E E+ + L A + L AE
Sbjct: 645 EEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKA 704
Query: 270 ELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPM-DSLAAEIEGTMRKEL 328
E+ AE + + EL+ K S + L + +SLA + R
Sbjct: 705 EV----AEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVA 760
Query: 329 QLEEAES 335
QLEE +S
Sbjct: 761 QLEEEKS 767
Score = 36.2 bits (82), Expect = 0.10
Identities = 58/253 (22%), Positives = 111/253 (43%), Gaps = 30/253 (11%)
Query: 42 ERVGQMTKTYNDIDAVTRLLEE-------KERDLELAARIGQSLLKKNKT-LTERN---E 90
E++ +M ++ R L+E + LEL R + L++++ L++R +
Sbjct: 1621 EKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRSRLGLSDREAQAQ 1680
Query: 91 LLEEQVEHIREEVSQLRHE---LSMKDELLQFYTSAAEESEP---ESVCSTPLKRNESSS 144
L+++V+ ++ +V+ + L + E L + EESE + V +SS+
Sbjct: 1681 ALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGALRDKVRGLTEALAQSSA 1740
Query: 145 SVQNYFHLD-SLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELR---- 199
S+ + + LQK L E + VL+ + + ++ K+ + + V+ LR
Sbjct: 1741 SLNSTRDKNLHLQKALTACEHDRQVLQERLDAAR-QALSEARKQSSSLGEQVQTLRGEVA 1799
Query: 200 DANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKD 259
D +Q +L + E ++QE L+ + LQ E L + LG+ +
Sbjct: 1800 DLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD-------ERRLLQERLGSLQR 1852
Query: 260 AQRQLTAELRELE 272
A QL AE RE+E
Sbjct: 1853 ALAQLEAEKREVE 1865
Score = 34.3 bits (77), Expect = 0.39
Identities = 61/265 (23%), Positives = 108/265 (40%), Gaps = 41/265 (15%)
Query: 36 EEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQ 95
E V +ER + T + + + R L+ E +L R Q + K K NE E
Sbjct: 1586 ESVRRSER--ERRATLDQVATLERSLQATESEL----RASQEKISKMKA----NETKLEG 1635
Query: 96 VEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSL 155
+ +EV ++K EL + + E E + R + ++Q+ +DSL
Sbjct: 1636 DKRRLKEVLDASESRTVKLELQR----RSLEGELQRSRLGLSDREAQAQALQD--RVDSL 1689
Query: 156 QKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKK 215
Q+++ D E + L+ +L EE E L RD ++ ++E LA+
Sbjct: 1690 QRQVADSEVKAGTLQLTVERLNGALAKVEESEGAL--------RD---KVRGLTEALAQS 1738
Query: 216 TEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDA-------QRQLTAEL 268
+ +++ HL QK AC + + L + L AA+ A L ++
Sbjct: 1739 SASLNSTRDKNLHL-------QKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQV 1791
Query: 269 RELEDKYAECMEMLHEAQEELKNLR 293
+ L + A+ EA+ +L+ LR
Sbjct: 1792 QTLRGEVADLELQRVEAEGQLQQLR 1816
Score = 33.9 bits (76), Expect = 0.51
Identities = 32/137 (23%), Positives = 60/137 (43%), Gaps = 11/137 (8%)
Query: 232 QIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKN 291
Q+ D++ + +A L + L ++ +R L +L+ L DK M+ +AQ E++
Sbjct: 534 QVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQR 593
Query: 292 LR--NKTMPNTTSRRYHSLGLFPM---------DSLAAEIEGTMRKELQLEEAESPDITH 340
LR N+ + S HSL + + L A E R+ +LEE + +
Sbjct: 594 LRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQD 653
Query: 341 QKRVFETVRNINQVVKQ 357
RV + ++ ++Q
Sbjct: 654 GARVRRELERSHRQLEQ 670
Score = 32.3 bits (72), Expect = 1.5
Identities = 49/231 (21%), Positives = 95/231 (41%), Gaps = 16/231 (6%)
Query: 56 AVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKD- 114
A+ RL EE++R LA ++ L ++ N+ L E + + + ++ R EL ++
Sbjct: 218 ALIRLEEEQQRSASLA-QVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREA 276
Query: 115 ------ELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQ------KKLKDL 162
E Y S E S + + S V+ + D LQ + + +
Sbjct: 277 AWRREEESFNAYFSN-EHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAV 335
Query: 163 EEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQ 222
+E + L + ++ EK+ L ++LRD ++ ++++ + D A
Sbjct: 336 QEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADL 395
Query: 223 QEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELED 273
+T L + L+K+ N++L + L A + + Q A L E ED
Sbjct: 396 SARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAAL-ETED 445
>gi|119120918 coiled-coil domain containing 64 [Homo sapiens]
Length = 573
Score = 63.5 bits (153), Expect = 6e-10
Identities = 74/308 (24%), Positives = 131/308 (42%), Gaps = 43/308 (13%)
Query: 41 AERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIR 100
AE G D + ++ ++ +KE+DL LAAR+G++LL++N+ ++ + E + +++
Sbjct: 84 AEGAGPQPPPSQDPELLS-VIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKL 142
Query: 101 EEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLK 160
E + Q +HEL + E E E E S L+S K+L+
Sbjct: 143 EHLEQEKHELRRRFE--------NREGEWEGRVS----------------ELESDVKQLQ 178
Query: 161 D-LEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDA 219
D LE + + LR EA + K+ + ++ Q + D +L A+ +S ++ ED
Sbjct: 179 DELERQQIHLR-EADREKSRAVQELSEQNQRLLD---QLSRASEVERQLSMQVHALREDF 234
Query: 220 ARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECM 279
+ + ++ LQ + K + EL L A + L + EL+D+
Sbjct: 235 REKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILE 294
Query: 280 E-------MLHEAQEELKNLR------NKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRK 326
LH++Q EL+ +R + T R SL +EIE +M
Sbjct: 295 RQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEA 354
Query: 327 ELQLEEAE 334
E +E E
Sbjct: 355 EELEQERE 362
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 63.2 bits (152), Expect = 8e-10
Identities = 84/355 (23%), Positives = 156/355 (43%), Gaps = 54/355 (15%)
Query: 41 AERVGQMTKTYNDIDAVTRLLEEKERDL-----ELAARIGQSLLKKNKTLTERN-ELLEE 94
A+ V ++ + +++ V + LE+++ +L ++A+ I L K+K+ ER +E+
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNI--EALSKSKSNIERTCRTVED 1258
Query: 95 QVEHIR---EEVSQLRHELSMKDELLQFYTSAAEE--SEPESVCSTPLKRNESSSSVQNY 149
Q I+ E+ +QL H+L+M+ LQ E ES+ S K ++ +
Sbjct: 1259 QFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQ---- 1314
Query: 150 FHLDSLQKKLKDLEEENVVLRSEASQLKTETITYE------EKEQQLVNDCVKELRDANV 203
L++ + +EEE + A L++ + E+EQ+ + + L AN
Sbjct: 1315 ----QLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANS 1370
Query: 204 QIASIS--------------EELAKKTEDAARQQEEITHLL-SQIVDLQKKAKACAVENE 248
++A EE KK ++ EE T S+ L+K + E E
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVE 1430
Query: 249 ELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSL 308
+L++ L + A L + R + AE + L E+Q EL+ + ++ R S
Sbjct: 1431 DLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKES-------RSLST 1483
Query: 309 GLFPMDSLAAEIEG---TMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSL 360
LF M + E+ T+R+E + + E D+T Q + ET +N+ + K + L
Sbjct: 1484 ELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQ--IAETGKNLQEAEKTKKL 1536
Score = 46.2 bits (108), Expect = 1e-04
Identities = 54/279 (19%), Positives = 122/279 (43%), Gaps = 20/279 (7%)
Query: 16 DCQDEERKPTHRQHDTQDLLE-----EVLCAERVGQMTKTYNDIDAVTRLLEEKERDLE- 69
D Q + + T D ++ E ++L +V ++T+ + + + L K+R+LE
Sbjct: 890 DLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLED 949
Query: 70 LAARIGQSLLKKNKTLTE---RNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEE 126
+ + + + TLT+ E +V+++ EE++ L +S L + +E
Sbjct: 950 KCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISK----LTKEKKSLQE 1005
Query: 127 SEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEK 186
+ +++ ++ ++ + ++ L+ L+ E+ LR++ + K + E
Sbjct: 1006 AHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKL----EG 1061
Query: 187 EQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVE 246
+ ++ + + +L + QI E+L KK + ++ Q +I + QKK K
Sbjct: 1062 DLKMSQESIMDLENDKQQI---EEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQAR 1118
Query: 247 NEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEA 285
EEL + + A + ++ + +L + E E L EA
Sbjct: 1119 IEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEA 1157
Score = 44.7 bits (104), Expect = 3e-04
Identities = 83/488 (17%), Positives = 176/488 (36%), Gaps = 60/488 (12%)
Query: 17 CQDEERKPTHRQHDTQDLLEEVLCAERV-GQMTKTYNDIDAVT----RLLEEKERDLELA 71
C E+ Q + +DL+ ++ + + K + D V + L+E + +LE A
Sbjct: 1415 CASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAA 1474
Query: 72 ARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPES 131
+ +SL + + E + +Q+E +R E L+ E+S E + +E+E
Sbjct: 1475 QKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTK 1534
Query: 132 VCSTPLK--------------RNESSSSVQNYFHLDS----LQKKLKDLEEENVVLRSEA 173
K +E S ++ L L +K+ + +EE L+ +
Sbjct: 1535 KLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNS 1594
Query: 174 SQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQI 233
+ + + E + ND ++ + + + +L A Q+ + + Q+
Sbjct: 1595 QRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQL 1654
Query: 234 VDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNL- 292
D Q NE+L + L + L EL E++ + +++EL +
Sbjct: 1655 KDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDAS 1714
Query: 293 --------RNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRV 344
+N ++ NT + + AE+E ++++ EE IT +
Sbjct: 1715 DRVQLLHSQNTSLINTKKKLEADIA-----QCQAEVENSIQESRNAEEKAKKAITDAAMM 1769
Query: 345 FETVRNINQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNK 404
E +K+ T + + N + L + + G L+N+
Sbjct: 1770 AEE-------LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENR 1822
Query: 405 TNSIILETEAADLGNDERSKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQER 464
+ E + +K G G+H E ++ ++ + E + +
Sbjct: 1823 VRELENELDV--------EQKRGAEALKGAHKYERKVKEMTYQAEE--------DHKNIL 1866
Query: 465 KLQELAEK 472
+LQ+L +K
Sbjct: 1867 RLQDLVDK 1874
Score = 44.3 bits (103), Expect = 4e-04
Identities = 61/284 (21%), Positives = 125/284 (44%), Gaps = 27/284 (9%)
Query: 88 RNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEP--ESVCSTPLKRNESSSS 145
R + LEE++ + +E + L+ ++ + E L A E E +S K E +
Sbjct: 873 RRKELEEKMVSLLQEKNDLQLQVQSETENLM---DAEERCEGLIKSKILLEAKVKELTER 929
Query: 146 VQNYFHLDS-LQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQ 204
++ ++S L K ++LE++ L+ + L+ T+T EKE+ + VK L + +
Sbjct: 930 LEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLEL-TLTKVEKEKHATENKVKNLSE---E 985
Query: 205 IASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQH---LGAAKDAQ 261
+ ++ E ++K T++ QE L + + K N +L Q L + + +
Sbjct: 986 MTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQE 1045
Query: 262 RQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIE 321
++L A+L + K ++M E+ +L+N + + + F + L A+I+
Sbjct: 1046 KKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKE------FELSQLQAKID 1099
Query: 322 GTMRKELQLE------EAESPDITHQKRVFETVRNINQVVKQRS 359
LQ + +A ++ + T+R ++ KQRS
Sbjct: 1100 DEQVHSLQFQKKIKELQARIEELEEEIEAEHTLR--AKIEKQRS 1141
Score = 42.7 bits (99), Expect = 0.001
Identities = 61/282 (21%), Positives = 121/282 (42%), Gaps = 41/282 (14%)
Query: 20 EERKPTHRQHDTQDLLEEVLCAE-RVGQMTKTYNDIDAVTRLLE---EKER----DLELA 71
+E+K H Q L+++ E +V + K ++ T LE E+E+ DLE A
Sbjct: 998 KEKKSLQEAH--QQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERA 1055
Query: 72 ARIGQSLLKKNKT----LTERNELLEEQVEHIREEVSQLR--------HELSMKDELLQF 119
R + LK ++ L + +EE+++ E+SQL+ H L + ++ +
Sbjct: 1056 KRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKEL 1115
Query: 120 YT---SAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQL 176
EE E E +++ S L ++L+++ E EAS
Sbjct: 1116 QARIEELEEEIEAEHTLRAKIEKQRSD-----------LARELEEISER----LEEASGA 1160
Query: 177 KTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDA-ARQQEEITHLLSQIVD 235
+ I +K + ++L +A +Q + + L KK D+ A E+I +L
Sbjct: 1161 TSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQK 1220
Query: 236 LQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAE 277
L+K+ +E +++ ++ A ++ + R +ED+++E
Sbjct: 1221 LEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSE 1262
Score = 38.5 bits (88), Expect = 0.021
Identities = 56/250 (22%), Positives = 110/250 (44%), Gaps = 44/250 (17%)
Query: 55 DAVTRLLEEKERDLELAARIGQSLL----KKNKTLTERNELLEEQVEHIREEVSQLRHEL 110
+ + LL+EK DL+L + L ++ + L + LLE +V+ + E +L E
Sbjct: 879 EKMVSLLQEKN-DLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTE---RLEEEE 934
Query: 111 SMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKL----------- 159
M EL+ A++ E CS+ LKR+ +D L+ L
Sbjct: 935 EMNSELV------AKKRNLEDKCSS-LKRD-----------IDDLELTLTKVEKEKHATE 976
Query: 160 ---KDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKT 216
K+L EE L S+L E + +E QQ ++D E N + I+ +L ++T
Sbjct: 977 NKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVN-GLIKINAKLEQQT 1035
Query: 217 EDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYA 276
+D E+ L + + ++K + ++E + L ++ ++Q+ +L++ E + +
Sbjct: 1036 DDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDL---ENDKQQIEEKLKKKEFELS 1092
Query: 277 ECMEMLHEAQ 286
+ + + Q
Sbjct: 1093 QLQAKIDDEQ 1102
Score = 30.4 bits (67), Expect = 5.7
Identities = 23/103 (22%), Positives = 50/103 (48%), Gaps = 7/103 (6%)
Query: 200 DANVQIASISEELAKKTEDAARQQ-------EEITHLLSQIVDLQKKAKACAVENEELVQ 252
+A ++A++ E+ + E+ AR + E++ LL + DLQ + ++ + +
Sbjct: 848 EAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEE 907
Query: 253 HLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNK 295
++ L A+++EL ++ E EM E + +NL +K
Sbjct: 908 RCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDK 950
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 63.2 bits (152), Expect = 8e-10
Identities = 89/445 (20%), Positives = 177/445 (39%), Gaps = 42/445 (9%)
Query: 41 AERVGQMTKTYNDIDA----VTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQV 96
+E G+ T ++A V++L ++ ++ E A + +SL + + ER+ LE
Sbjct: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQ 1168
Query: 97 EHIREEVSQLRHE----LSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHL 152
+ E+ +L H S + EL F T + S+ E + R + +N +
Sbjct: 1169 GQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSL-I 1227
Query: 153 DSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEEL 212
SL++++ L + + E+ +LK + EK Q+L + LR + AS
Sbjct: 1228 SSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLE----ERLRLLQAETAS----- 1278
Query: 213 AKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELE 272
++AR E + L ++ L+++A+ V +E L Q L + + +L EL+ +
Sbjct: 1279 -----NSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQ 1333
Query: 273 DKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAE------------I 320
+K+ + + L Q L++ + + + H + AAE
Sbjct: 1334 EKFFQKEQALSTLQ--LEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQA 1391
Query: 321 EGTMRKELQLEEAESPD-ITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSAMNSL 379
G +R EL + E + I +++V E R Q+ +++ +++ A L
Sbjct: 1392 AGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSM----LKKAHGLL 1447
Query: 380 LSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDERSKKPGTPGTPGSHDLET 439
+ G V LD + E A + R + + +LE
Sbjct: 1448 AEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEV 1507
Query: 440 ALRRLSLRRENYLSERRFFEEEQER 464
+ + L ER+ F+EE+++
Sbjct: 1508 MTAKYEGAKVKVLEERQRFQEERQK 1532
Score = 55.8 bits (133), Expect = 1e-07
Identities = 111/530 (20%), Positives = 208/530 (39%), Gaps = 110/530 (20%)
Query: 16 DCQDEERKPTHRQHDT----QDLLEEVLCAER-VGQMTKTYNDI---------------D 55
+ +D+ T R H+T QDL E +R + Q+++ D+ D
Sbjct: 280 ELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQD 339
Query: 56 AVTRLLEEKERD----LELAARIGQSL---LKKNKTLTERNELLEEQVEHIREEVSQLRH 108
A+ L EE + LE A++ + L L+ K L E+NE+L+ ++ + E +SQL
Sbjct: 340 ALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQL-- 397
Query: 109 ELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVV 168
+++ P+ E + + L++L+++ L N
Sbjct: 398 ----------------QDNPPQ----------EKGEVLGDVLQLETLKQEAATLAANNTQ 431
Query: 169 LRSEASQLKTETITYE----------EKEQQLVNDCVKELRDANVQIASISEELAKKTE- 217
L++ L+TE E E+E+Q ++ + +L+ + ++ EEL + ++
Sbjct: 432 LQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQA 491
Query: 218 DAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRE------- 270
AR ++ L S++ L + +++EL AK+ Q QL L++
Sbjct: 492 HGARLTAQVASLTSELTTLNATIQQ---QDQELAGLKQQAKEKQAQLAQTLQQQEQASQG 548
Query: 271 LEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKE--- 327
L + + L + +++LK + K +R+ H+ L + A E E ++R+
Sbjct: 549 LRHQVEQLSSSLKQKEQQLKEVAEK---QEATRQDHAQQL---ATAAEEREASLRERDAA 602
Query: 328 ------LQLEEAESPDITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSAMNSLLS 381
L+ E+A +I Q+ V N + Q S+T + + S L
Sbjct: 603 LKQLEALEKEKAAKLEILQQQL---QVANEARDSAQTSVTQAQRE---KAELSRKVEELQ 656
Query: 382 SCVSTPRSSFYGSDIGNVVLD--------NKTNSIILETEAADLGNDERSKKPGTPGTPG 433
+CV T R + + L+ T + E L ++ K T G
Sbjct: 657 ACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKG 716
Query: 434 SHDLE-----TALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELRSG 478
S + E AL +E R E+ +R+ +EL E+ R G
Sbjct: 717 SLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKG 766
Score = 52.4 bits (124), Expect = 1e-06
Identities = 74/329 (22%), Positives = 140/329 (42%), Gaps = 38/329 (11%)
Query: 39 LCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEH 98
L E+ Q+ ID + LL EK+ L + + L KN++LT R +Q +
Sbjct: 243 LLTEKDAQIAMMQQRIDRLA-LLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQD 301
Query: 99 IREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKK 158
++ E SQ+ +++ + SE S L+ S HL LQ
Sbjct: 302 LKTEKSQMDRKIN-------------QLSEENGDLSFKLREFAS--------HLQQLQDA 340
Query: 159 LKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANV----QIASISEELAK 214
L +L EE+ S+A+Q E EKE K L + N +++ + E L++
Sbjct: 341 LNELTEEH----SKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQ 396
Query: 215 KTEDAARQQEEITHLLSQIVDLQKKAKACAVENEEL---VQHLGAAKDAQR-QLTAELRE 270
++ +++ E+ + Q+ L+++A A N +L V+ L + Q +L AE
Sbjct: 397 LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGH 456
Query: 271 LEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGL-FPMDSLAAEIEGTMRKELQ 329
E++ + ++ + Q + NL + + H L + SL +E+ T+ +Q
Sbjct: 457 FEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELT-TLNATIQ 515
Query: 330 LEEAESPDITHQKRVFETVRNINQVVKQR 358
++ E + Q + E + Q ++Q+
Sbjct: 516 QQDQELAGLKQQAK--EKQAQLAQTLQQQ 542
Score = 45.4 bits (106), Expect = 2e-04
Identities = 69/348 (19%), Positives = 143/348 (41%), Gaps = 58/348 (16%)
Query: 31 TQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTE--- 87
TQ L+ E+L A+ + Q + A R EE E+ + A + LL+ + L E
Sbjct: 1353 TQALVSELLPAKHLCQQLQA-EQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIP 1411
Query: 88 -RNELLEEQ--VEHIREEVSQLRHELSMK-----------------------------DE 115
R ++ E++ + +R E + +LSM D+
Sbjct: 1412 LRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQ 1471
Query: 116 LLQFYTS--AAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEE------ENV 167
+ Y AA ++ E+ + + +S++ K+K LEE E
Sbjct: 1472 AREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQ 1531
Query: 168 VLRSEASQLKTETITYEEKEQQLVNDCVKELRDANV-------QIASISEELAKKTEDAA 220
L ++ QL+ ++ ++ + V + K+L D++ ++ ++ + + ++A
Sbjct: 1532 KLTAQVEQLEV----FQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQ 1587
Query: 221 RQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECME 280
R Q ++ L +Q+ ++ A+ ++ E+ H A K ++L +LR LE E E
Sbjct: 1588 RLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKE 1647
Query: 281 MLHEAQ---EELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMR 325
+ EA+ EL+ KT + R+ + + +++ A + +R
Sbjct: 1648 LRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLR 1695
Score = 40.4 bits (93), Expect = 0.005
Identities = 75/324 (23%), Positives = 132/324 (40%), Gaps = 32/324 (9%)
Query: 18 QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLL---EEKERDLELAARI 74
Q+ ERK + L EEV R Q+ + + + RL+ EK + LE R+
Sbjct: 1218 QEAERKNSL----ISSLEEEVSILNR--QVLEKEGESKELKRLVMAESEKSQKLEERLRL 1271
Query: 75 GQSLLKKNKT-LTERNELLEEQVEHIREEVSQLR-HELSMKDELLQFYTSAAEESEPESV 132
Q+ N ER+ L E+V+ +REE + R +++ EL A E +
Sbjct: 1272 LQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKA 1331
Query: 133 CSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQ--QL 190
+ E + S H + + L +++ + +A Q E EE EQ Q
Sbjct: 1332 WQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQA 1391
Query: 191 VNDCVKELRDANVQIAS---ISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVEN 247
EL A ++ + +++A++ A + + E Q+ L+K A EN
Sbjct: 1392 AGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEEN 1451
Query: 248 EELVQHLGAAKDAQRQ-LTAELRELEDKYA-ECMEMLHEAQEELKNLRNKTMPNTTSRRY 305
+ LG + RQ L EL + +KY E + +A+ L ++ + +T+R
Sbjct: 1452 ----RGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREA--QSTARE- 1504
Query: 306 HSLGLFPMDSLAAEIEGTMRKELQ 329
++ + A+ EG K L+
Sbjct: 1505 -------LEVMTAKYEGAKVKVLE 1521
Score = 32.0 bits (71), Expect = 2.0
Identities = 61/299 (20%), Positives = 117/299 (39%), Gaps = 40/299 (13%)
Query: 46 QMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERN-ELLEEQ--------- 95
+M T ++ + L+ + E A+R L+K+ +R E LEEQ
Sbjct: 908 KMAATSKEVARLETLVRKAGEQQETASR---ELVKEPARAGDRQPEWLEEQQGRQFCSTQ 964
Query: 96 --VEHIREEVSQLRHELS-MKDELLQFYTSAAEE---SEPESVCSTPLKRNESSSSVQNY 149
++ + E Q+ +EL ++ L++ EE E E T + +
Sbjct: 965 AALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEK 1024
Query: 150 FHLDSLQKKLKD-LEEENVVLRSEASQLKTETITYEEKEQQLVN------DCVKELRDAN 202
L+ +L++ L E+ V + L E K+Q+L +KEL +
Sbjct: 1025 AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELR 1084
Query: 203 VQIASISEELAKK-----------TEDAARQQEEITHLLSQIVDLQKKAKACAVENEE-- 249
+ + E+LAKK +E A R + L + ++ K + C + E+
Sbjct: 1085 QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144
Query: 250 -LVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHS 307
L + L A + ++ + + L L+ + E + L +Q L + + + T + HS
Sbjct: 1145 SLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHS 1203
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 61.6 bits (148), Expect = 2e-09
Identities = 65/286 (22%), Positives = 120/286 (41%), Gaps = 34/286 (11%)
Query: 21 ERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLK 80
E K T +T L EE+ A +TY K + +EL R+ + K
Sbjct: 341 EEKNTMYMQNTVSLEEELRKANAARSQLETY------------KRQVVELQNRLSEESKK 388
Query: 81 KNKTLTERNELLEEQVEHIREEVSQLRHEL-SMKDELLQFYTSAAEESEPESVCSTPLKR 139
+K L + L+E+V+ +++E +LR E S+K+ + + A+E + + PL
Sbjct: 389 ADK-LDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGS 447
Query: 140 NESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELR 199
ESS S+ +++KL L+ EN +L+ + E + + + L
Sbjct: 448 QESSDSLAAEIVTPEIREKLIRLQHENKMLK----------LNQEGSDNEKIALLQSLLD 497
Query: 200 DANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKD 259
DAN++ + E + Q ++ L + D KA+ + ++L +HL +
Sbjct: 498 DANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAEDSVLLKKKLEEHLEKLHE 557
Query: 260 AQRQLTAELRELED----------KYAECMEMLHEAQEELKNLRNK 295
A +L + +ED K E E L + +EE+K + +
Sbjct: 558 ANNELQKKRAIIEDLEPRFNNSSLKIEELQEALRKKEEEMKQMEER 603
Score = 48.9 bits (115), Expect = 2e-05
Identities = 94/419 (22%), Positives = 163/419 (38%), Gaps = 86/419 (20%)
Query: 83 KTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNES 142
KT E NE L +EE++Q HEL M+ LQ E+S + ++R
Sbjct: 180 KTTEELNEALSA-----KEEIAQRCHELDMQVAALQ-----EEKSSLLAENQVLMERLNQ 229
Query: 143 SSSVQN------YFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVK 196
S S+++ HL LQ +L+ L+EE L + + I EE E++ +
Sbjct: 230 SDSIEDPNSPAGRRHLQ-LQTQLEQLQEETFRLEAAKDDYR---IRCEELEKE-----IS 280
Query: 197 ELRDANVQIASISEEL-------------AKKTEDAARQQEEITHLLSQIVDLQKKAKAC 243
ELR N ++ ++++E + K Q E L + DL+++ K
Sbjct: 281 ELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLL 340
Query: 244 AVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSR 303
+N +Q+ + ++ R+ A +LE + +E+ + EE K
Sbjct: 341 EEKNTMYMQNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKK------------ 388
Query: 304 RYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQR-SLTP 362
D L E + K L++ + T + + ET+ + V Q LT
Sbjct: 389 ---------ADKLDFEYKRLKEKVDSLQKEKDRLRTERDSLKETIEELRCVQAQEGQLTT 439
Query: 363 SPMNIPGSNQSSAMNSLLSSCVSTP--RSSFYGSDIGNVVLDNKTNSIILETEAADLGND 420
+ GS +SS L++ + TP R + L ++ + L E +D N+
Sbjct: 440 QGLMPLGSQESS---DSLAAEIVTPEIREKL-------IRLQHENKMLKLNQEGSD--NE 487
Query: 421 ERSKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFE-----EEQERKLQELAEKGE 474
+ + + LR+ L EN L +R E EE ++ LQ+ K E
Sbjct: 488 KIALLQSLLD-------DANLRKNELETENRLVNQRLLEVQSQVEELQKSLQDQGSKAE 539
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding
domain 1 [Homo sapiens]
Length = 1412
Score = 61.2 bits (147), Expect = 3e-09
Identities = 63/256 (24%), Positives = 122/256 (47%), Gaps = 25/256 (9%)
Query: 93 EEQVEHIREEVSQLRH---ELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNY 149
+E + + +EVS+L E KD ++ + E + +T ++NE S +
Sbjct: 227 DEIILLLGKEVSRLSDYEIESKYKDVIIANLQNEVAELSQKVSETTTSRQNEKEISQKCQ 286
Query: 150 F---HLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANV--- 203
+D+ QK+++ L+ + L+ S++ +T++ E + + + L+ N
Sbjct: 287 VLDEDIDAKQKEIQSLKSQISALQKGYSKVLCQTLSERNSEITSLKNEGENLKRDNAITS 346
Query: 204 -QIASISEELAKKTEDAARQQEEITHLLSQIVD----LQKKAKACAVENEELVQHLGAAK 258
++S+ +++ K E + +EE++HL SQ D L+ C+V EEL Q +
Sbjct: 347 GMVSSLQKDILAKDEQVQQLKEEVSHLKSQNKDKDHQLEALGSRCSVLKEELKQ-----E 401
Query: 259 DAQRQLTAELRELEDKYAE-CMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLA 317
DA R ELRE ++K + C + + ++E+K LR + + T + S L +
Sbjct: 402 DAHR----ELREAQEKELKLCKTQIQDMEKEMKKLRAELRKSCTEQSVISRTLREKSKVE 457
Query: 318 AEI-EGTMRKELQLEE 332
++ E + RK LQL+E
Sbjct: 458 EKLQEDSRRKLLQLQE 473
Score = 39.7 bits (91), Expect = 0.009
Identities = 45/199 (22%), Positives = 87/199 (43%), Gaps = 30/199 (15%)
Query: 39 LCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKN-------KTLTER--- 88
LC R G + +D L ++ L+++ +G + KN K L+ +
Sbjct: 1218 LCNARFGSAMEKSGKMDVAEALELSEKLYLDMSKTLGSLMNIKNMSGHVSMKYLSRQERE 1277
Query: 89 --NELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSV 146
N+L + ++ + ++++QL+++L K+ELL+ Y E+ L+R S S+
Sbjct: 1278 KVNQLRQRDLDLVFDKITQLKNQLGRKEELLRGYEKDVEQ----------LRR--SKVSI 1325
Query: 147 QNYFHLDSLQKKLKD---LEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANV 203
+ Y S KL+D E E L EA + + E++ + + R A++
Sbjct: 1326 EMY---QSQVAKLEDDIYKEAEEKALLKEALERMEHQLCQEKRINRAIRQQKVGTRKASL 1382
Query: 204 QIASISEELAKKTEDAARQ 222
++ E L K+T + Q
Sbjct: 1383 KMDQEREMLRKETSSKSSQ 1401
Score = 36.6 bits (83), Expect = 0.079
Identities = 85/452 (18%), Positives = 173/452 (38%), Gaps = 65/452 (14%)
Query: 37 EVLC---AERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLE 93
+VLC +ER ++T N+ E +RD + + + SL K E+ + L+
Sbjct: 315 KVLCQTLSERNSEITSLKNEG-------ENLKRDNAITSGMVSSLQKDILAKDEQVQQLK 367
Query: 94 EQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLD 153
E+V H++ + H+L E L S +E + L+ + +
Sbjct: 368 EEVSHLKSQNKDKDHQL----EALGSRCSVLKEELKQEDAHRELREAQEKELKLCKTQIQ 423
Query: 154 SLQKKLKDLEEENVVLRSEASQLKTETITYEEK---EQQLVNDCVKELRDANVQIASISE 210
++K++K L E LR ++ + T EK E++L D ++L +Q+ +
Sbjct: 424 DMEKEMKKLRAE---LRKSCTEQSVISRTLREKSKVEEKLQEDSRRKL----LQLQEMGN 476
Query: 211 ELAKKTEDAARQQEEITHLLSQIVDL----QKKAKACAVENEELVQHLGAAKDAQRQLTA 266
+ + R ++ H SQ++ K + V +++L++ + Q+T
Sbjct: 477 RESVIKINLERAVGQLEHFRSQVIKATYGRAKPFRDKPVTDQQLIEKI-------TQVTE 529
Query: 267 ELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRK 326
+ + K + + + +L N + + + SL + ++K
Sbjct: 530 DNINFQQK-----KWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKK 584
Query: 327 ELQLEE--AESPDITH-QKRVFETVRN-------INQVVKQRSLTPSPMNIPGSNQSSAM 376
E+ L + SP ++ QK V + +R+ + Q+++ + PS N Q S
Sbjct: 585 EVDLLQHLQVSPPVSGLQKVVLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGN 644
Query: 377 NSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILETEAADLGNDERSKKPGTPGTPGSHD 436
+++ ++ + S G E A + +S+ T G G
Sbjct: 645 SAVFTAGKAAGASGREGE---------------AERGEARARGEAQSQNQATDGREGGKA 689
Query: 437 LETALRRLSLRRENYLSERRFFEEEQERKLQE 468
LE + + R + L E R +E E L +
Sbjct: 690 LEEYITQERNRAKETLEEERKRMQELESLLAQ 721
Score = 33.5 bits (75), Expect = 0.67
Identities = 66/332 (19%), Positives = 119/332 (35%), Gaps = 59/332 (17%)
Query: 18 QDEERKPTHRQHDT-QDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQ 76
Q EE + ++ D + L + L Q TK + A + L+ E EL +
Sbjct: 830 QKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKAESLALKLNETLAELETTKTK 889
Query: 77 SLLKKNKTLTERNEL-------------LEEQVEHIREEVSQLRHELSMKDELLQFYTS- 122
++ + + + ++ + EE++ +E++ Q + +E LQ T
Sbjct: 890 MIMVEERLILQQKMVKALQDEQESQRHGFEEEIMEYKEQIKQHAQTIVSLEEKLQKVTQH 949
Query: 123 ----------------AAEESEPESVCSTPLKRNESSSSVQNYFHL-------------- 152
A +E P+ P+ ESS+ Y HL
Sbjct: 950 HKKIEGEIATLKDNDPAPKEERPQDPLVAPM--TESSAKDMAYEHLIDDLLAAQKEILSQ 1007
Query: 153 -DSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEE 211
+ + K KDL E + + +L + E+ LV KEL ++A +S
Sbjct: 1008 QEVIMKLRKDLTEAHSRMSDLRGELNEKQKMELEQNVVLVQQQSKELSVLKEKMAQMSSL 1067
Query: 212 LAKK------TEDAARQQEEITHLLSQIVDLQ----KKAKACAVENEELVQHLGAAKDAQ 261
+ KK E+A R +E H L + + KK + C + H A +Q
Sbjct: 1068 VEKKDRELKALEEALRASQE-KHRLQLNTEKEQKPRKKTQTCDTSVQIEPVHTEAFSSSQ 1126
Query: 262 RQLTAELRELEDKYAECMEMLHEAQEELKNLR 293
Q + + K + E++ ++ L LR
Sbjct: 1127 EQQSFSDLGVRCKGSRHEEVIQRQKKALSELR 1158
Score = 29.6 bits (65), Expect = 9.7
Identities = 28/92 (30%), Positives = 49/92 (53%), Gaps = 18/92 (19%)
Query: 213 AKKT-EDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELREL 271
AK+T E+ ++ +E+ LL+Q QKKA A ++ E+ K+A + ++EL
Sbjct: 701 AKETLEEERKRMQELESLLAQ----QKKALAKSITQEK-----NRVKEALEEEQTRVQEL 751
Query: 272 EDKYAECMEML-----HE---AQEELKNLRNK 295
E++ A E+L HE A+E L++ + K
Sbjct: 752 EERLARQKEVLESSIAHEKRKAKEALESEKRK 783
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 60.5 bits (145), Expect = 5e-09
Identities = 81/357 (22%), Positives = 149/357 (41%), Gaps = 53/357 (14%)
Query: 9 EEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDL 68
EEE Q E +K + D ++ LEE A + Q+ K VT + K+ +
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK-------VTAEAKIKKLED 985
Query: 69 ELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESE 128
E+ Q N L++ +LLEE++ + +++ + +L + S E E
Sbjct: 986 EILVMDDQ-----NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Query: 129 PESVCSTPLKRNESSSSVQNYFHLDSLQKKLK----DLEEENVVLRSEASQLKTETITYE 184
LK+ E S L+ L++KL+ D E+ L+++ ++LK + E
Sbjct: 1041 ------VRLKKEEKSRQ-----ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 185 EKEQQLV----------NDCVKELRDANVQIASISEEL----------AKKTEDAARQQE 224
E+ Q + N+ +K++R+ I+ + E+L K+ D + E
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 225 EITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQ-RQLTAELRELEDKYAECMEMLH 283
+ L +D + + E+ V L A D + R A+++E+ K+A+ +E L
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209
Query: 284 EAQEELKNLRNKTMPN--TTSRRYHSLG--LFPMDSLAAEIEGTMRK-ELQLEEAES 335
E E+ K + N T + L L + E+E +K E Q++E +S
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266
Score = 53.1 bits (126), Expect = 8e-07
Identities = 59/278 (21%), Positives = 113/278 (40%), Gaps = 26/278 (9%)
Query: 18 QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQS 77
++ E+K + D L E++ AER + EKE ELA + S
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADL------------EKE---ELAEELASS 1720
Query: 78 LLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPL 137
L +N L + LE ++ + EE+ + + + + ++ T AE+ E
Sbjct: 1721 LSGRN-ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779
Query: 138 KRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKE 197
+ S+ Q L+ KL ++E + S+ K+ E K QL +E
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEME------GAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 198 LRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAA 257
R+ S+ ++ KK ++ Q E+ + Q + +K A ++L + L A
Sbjct: 1834 AREKQAATKSLKQK-DKKLKEILLQVEDERKMAEQYKEQAEKGNA---RVKQLKRQLEEA 1889
Query: 258 KDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNK 295
++ +++ A R+L+ + E E E+ L++K
Sbjct: 1890 EEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 50.8 bits (120), Expect = 4e-06
Identities = 80/363 (22%), Positives = 151/363 (41%), Gaps = 60/363 (16%)
Query: 46 QMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVE---HIREE 102
Q+T+ ++ A L++ + + A + L +K+ LTE LL+EQ++ + E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 103 VSQLRHELSMK----DELLQFYTSAAEESEPESVCSTPLKRN------------ESSSSV 146
++R L+ K +E+L + EE E ++ E +
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 147 QNYFHLDSL--QKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDA--- 201
+ L+ + + K+K LE+E +V+ + ++L E EE+ L + +E A
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025
Query: 202 ----NVQIASISE-ELAKKTEDAARQQ----------------EEITHLLSQIVDLQKKA 240
N + ISE E+ K E+ +RQ+ E+I L +QI +L+ +
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ- 1084
Query: 241 KACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNT 300
A + EEL L D Q L+ K E + + QE+L + + N
Sbjct: 1085 --LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDS--ERAARNK 1136
Query: 301 TSRRYHSLGLFPMDSLAAEIEGTM-----RKELQLEEAESPDITHQKRVFETVRNINQVV 355
++ LG +++L E+E T+ ++EL+ + + + + ET + QV
Sbjct: 1137 AEKQKRDLG-EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 356 KQR 358
+ R
Sbjct: 1196 EMR 1198
Score = 50.8 bits (120), Expect = 4e-06
Identities = 95/466 (20%), Positives = 185/466 (39%), Gaps = 49/466 (10%)
Query: 29 HDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTER 88
H+ + LEE E GQ + A L E++ + E AAR Q L + T +
Sbjct: 925 HEMEARLEE---EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR--QKLQLEKVTAEAK 979
Query: 89 NELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQN 148
+ LE+++ + ++ ++L E + +E + T+ E E ++ T LK S +
Sbjct: 980 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039
Query: 149 YFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASI 208
L +K ++LE+ L +AS D +++ D QIA +
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDAS------------------DFHEQIADLQAQIAEL 1081
Query: 209 SEELAKKTED----AARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQ- 263
+LAKK E+ AR +EI + + +++ + E+L A A++Q
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 264 ---------LTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMD 314
L EL + D A E+ + ++E+ L+ T R H + M
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET---RSHEAQVQEMR 1198
Query: 315 SLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQ-- 372
A+ + ++L+ + ++ K+ E N + + R L + + +
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK-ENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 373 SSAMNSLLSSCVSTPRSSFYGSDIGNVV--LDNKTNSIILETEAADLGNDERSKKPGTPG 430
+ + L S C R+ +++ + V L N+ S+ A+ G + K
Sbjct: 1258 EAQVQELQSKCSDGERAR---AELNDKVHKLQNEVESVTGMLNEAE-GKAIKLAKDVASL 1313
Query: 431 TPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELR 476
+ D + L+ + ++ N ++ R EEE+ +L E+ E +
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Score = 48.9 bits (115), Expect = 2e-05
Identities = 71/360 (19%), Positives = 140/360 (38%), Gaps = 29/360 (8%)
Query: 17 CQDEERKPTH---RQHDTQDLLEEV--LCAERVGQMTKTYNDIDAVTRLLEEKERDLELA 71
C D ER + H Q+ +E V + E G+ K D+ +++ L++ + L+
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327
Query: 72 ARIGQSLLKKNKTLTERNELLEEQVE-------HIREEVSQLRHELSMKDELLQFYTSAA 124
R ++ K + L E L++Q++ ++ +S L +LS + LQ + S
Sbjct: 1328 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 125 EESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYE 184
E E N + + D L+K L++E L + + + ++
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-QLVSNL 1446
Query: 185 EKEQQLVNDCVKELRDANVQIASISE----ELAKKTEDAARQQEEITHLLSQIVDLQKKA 240
EK+Q+ + + E ++ + + A + E +K A + L +L++
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1506
Query: 241 KACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNT 300
K E E+LV +L R LE + E L E ++EL+ + +
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 301 TSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSL 360
+ M +L + E ++ + E + + Q +ET + KQR+L
Sbjct: 1567 VN----------MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET--ELEDERKQRAL 1614
Score = 48.1 bits (113), Expect = 3e-05
Identities = 68/271 (25%), Positives = 121/271 (44%), Gaps = 65/271 (23%)
Query: 57 VTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDEL 116
V LL+ ++ E+ A+ + L+K K ER + E +++ + ++ SQL E ++ E
Sbjct: 841 VKPLLQVTRQEEEMQAK--EDELQKTK---ERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 117 LQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQL 176
LQ T E+E V L K ++LEE +L ++L
Sbjct: 896 LQAETELYAEAEEMRV---------------------RLAAKKQELEE---ILHEMEARL 931
Query: 177 KTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDL 236
+ E E++ QQL E + Q+ + E+L + E+AARQ+ Q+ +
Sbjct: 932 EEE----EDRGQQL----QAERKKMAQQMLDLEEQL--EEEEAARQK-------LQLEKV 974
Query: 237 QKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKT 296
+AK +E+E LV D +L+ E + LE++ ++ L E +E+ KNL
Sbjct: 975 TAEAKIKKLEDEILVM-----DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL---- 1025
Query: 297 MPNTTSRRYHSLGLFPMDSLAAEIEGTMRKE 327
T + H +S+ +E+E ++KE
Sbjct: 1026 ---TKLKNKH-------ESMISELEVRLKKE 1046
Score = 44.3 bits (103), Expect = 4e-04
Identities = 54/235 (22%), Positives = 105/235 (44%), Gaps = 34/235 (14%)
Query: 61 LEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFY 120
L+ EL A+ Q + K L E E QV+ +R++ +Q EL+ ++L QF
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT--EQLEQFK 1216
Query: 121 TSAAEESEPESVCSTPLKRNESSSSVQNYF---HLDSLQKKLKDLEEENVVLRSEASQLK 177
+ A L +N+ + +N L L + +++E + L ++ +L+
Sbjct: 1217 RAKAN-----------LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 178 TETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQ 237
++ E +L ND V +L++ ++ S++ L + A + +++ L SQ+ D Q
Sbjct: 1266 SKCSDGERARAEL-NDKVHKLQN---EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 238 KKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNL 292
+ + EE Q L ++ +LR+LE++ + L E E +NL
Sbjct: 1322 ELLQ------EETRQKLN--------VSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Score = 41.2 bits (95), Expect = 0.003
Identities = 69/371 (18%), Positives = 149/371 (40%), Gaps = 54/371 (14%)
Query: 18 QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQS 77
+D+ K H ++ LE QM + ++ + L+ E D +L +
Sbjct: 1520 KDDVGKNVHELEKSKRALET--------QMEEMKTQLEELEDELQATE-DAKLRLEVNMQ 1570
Query: 78 LLKKN--KTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCST 135
LK + L R+E EE+ ++ ++ + +E ++DE Q +AA + + E
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLHE--YETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 136 PLKRNESS--SSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVND 193
+ +S+ + L LQ ++KD + E R+ ++ E+K + L D
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688
Query: 194 CVKELRD----------ANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKAC 243
++ D A+++ ++EELA Q+E L ++I L+++ +
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 244 AVENEELVQHLGAAKDAQRQLTAEL--------------RELEDKYAECMEMLHEAQEEL 289
E + + A QL+ EL ++LE + E LHE + +
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808
Query: 290 KNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVR 349
K+ T + +++ A++E + +E + ++A + + + + + +
Sbjct: 1809 KSKFKST-------------IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI- 1854
Query: 350 NINQVVKQRSL 360
+ QV +R +
Sbjct: 1855 -LLQVEDERKM 1864
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 60.5 bits (145), Expect = 5e-09
Identities = 81/357 (22%), Positives = 149/357 (41%), Gaps = 53/357 (14%)
Query: 9 EEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDL 68
EEE Q E +K + D ++ LEE A + Q+ K VT + K+ +
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK-------VTAEAKIKKLED 992
Query: 69 ELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESE 128
E+ Q N L++ +LLEE++ + +++ + +L + S E E
Sbjct: 993 EILVMDDQ-----NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Query: 129 PESVCSTPLKRNESSSSVQNYFHLDSLQKKLK----DLEEENVVLRSEASQLKTETITYE 184
LK+ E S L+ L++KL+ D E+ L+++ ++LK + E
Sbjct: 1048 ------VRLKKEEKSRQ-----ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 185 EKEQQLV----------NDCVKELRDANVQIASISEEL----------AKKTEDAARQQE 224
E+ Q + N+ +K++R+ I+ + E+L K+ D + E
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 225 EITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQ-RQLTAELRELEDKYAECMEMLH 283
+ L +D + + E+ V L A D + R A+++E+ K+A+ +E L
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1216
Query: 284 EAQEELKNLRNKTMPN--TTSRRYHSLG--LFPMDSLAAEIEGTMRK-ELQLEEAES 335
E E+ K + N T + L L + E+E +K E Q++E +S
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273
Score = 53.1 bits (126), Expect = 8e-07
Identities = 59/278 (21%), Positives = 113/278 (40%), Gaps = 26/278 (9%)
Query: 18 QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQS 77
++ E+K + D L E++ AER + EKE ELA + S
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADL------------EKE---ELAEELASS 1727
Query: 78 LLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPL 137
L +N L + LE ++ + EE+ + + + + ++ T AE+ E
Sbjct: 1728 LSGRN-ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786
Query: 138 KRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKE 197
+ S+ Q L+ KL ++E + S+ K+ E K QL +E
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEME------GAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 198 LRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAA 257
R+ S+ ++ KK ++ Q E+ + Q + +K A ++L + L A
Sbjct: 1841 AREKQAATKSLKQK-DKKLKEILLQVEDERKMAEQYKEQAEKGNA---RVKQLKRQLEEA 1896
Query: 258 KDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNK 295
++ +++ A R+L+ + E E E+ L++K
Sbjct: 1897 EEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 50.8 bits (120), Expect = 4e-06
Identities = 80/363 (22%), Positives = 151/363 (41%), Gaps = 60/363 (16%)
Query: 46 QMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVE---HIREE 102
Q+T+ ++ A L++ + + A + L +K+ LTE LL+EQ++ + E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 103 VSQLRHELSMK----DELLQFYTSAAEESEPESVCSTPLKRN------------ESSSSV 146
++R L+ K +E+L + EE E ++ E +
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 147 QNYFHLDSL--QKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDA--- 201
+ L+ + + K+K LE+E +V+ + ++L E EE+ L + +E A
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032
Query: 202 ----NVQIASISE-ELAKKTEDAARQQ----------------EEITHLLSQIVDLQKKA 240
N + ISE E+ K E+ +RQ+ E+I L +QI +L+ +
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ- 1091
Query: 241 KACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNT 300
A + EEL L D Q L+ K E + + QE+L + + N
Sbjct: 1092 --LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDS--ERAARNK 1143
Query: 301 TSRRYHSLGLFPMDSLAAEIEGTM-----RKELQLEEAESPDITHQKRVFETVRNINQVV 355
++ LG +++L E+E T+ ++EL+ + + + + ET + QV
Sbjct: 1144 AEKQKRDLG-EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 356 KQR 358
+ R
Sbjct: 1203 EMR 1205
Score = 50.8 bits (120), Expect = 4e-06
Identities = 95/466 (20%), Positives = 185/466 (39%), Gaps = 49/466 (10%)
Query: 29 HDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTER 88
H+ + LEE E GQ + A L E++ + E AAR Q L + T +
Sbjct: 932 HEMEARLEE---EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR--QKLQLEKVTAEAK 986
Query: 89 NELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQN 148
+ LE+++ + ++ ++L E + +E + T+ E E ++ T LK S +
Sbjct: 987 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046
Query: 149 YFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASI 208
L +K ++LE+ L +AS D +++ D QIA +
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDAS------------------DFHEQIADLQAQIAEL 1088
Query: 209 SEELAKKTED----AARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQ- 263
+LAKK E+ AR +EI + + +++ + E+L A A++Q
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 264 ---------LTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMD 314
L EL + D A E+ + ++E+ L+ T R H + M
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET---RSHEAQVQEMR 1205
Query: 315 SLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQ-- 372
A+ + ++L+ + ++ K+ E N + + R L + + +
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK-ENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 373 SSAMNSLLSSCVSTPRSSFYGSDIGNVV--LDNKTNSIILETEAADLGNDERSKKPGTPG 430
+ + L S C R+ +++ + V L N+ S+ A+ G + K
Sbjct: 1265 EAQVQELQSKCSDGERAR---AELNDKVHKLQNEVESVTGMLNEAE-GKAIKLAKDVASL 1320
Query: 431 TPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELR 476
+ D + L+ + ++ N ++ R EEE+ +L E+ E +
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Score = 48.9 bits (115), Expect = 2e-05
Identities = 71/360 (19%), Positives = 140/360 (38%), Gaps = 29/360 (8%)
Query: 17 CQDEERKPTH---RQHDTQDLLEEV--LCAERVGQMTKTYNDIDAVTRLLEEKERDLELA 71
C D ER + H Q+ +E V + E G+ K D+ +++ L++ + L+
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334
Query: 72 ARIGQSLLKKNKTLTERNELLEEQVE-------HIREEVSQLRHELSMKDELLQFYTSAA 124
R ++ K + L E L++Q++ ++ +S L +LS + LQ + S
Sbjct: 1335 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 125 EESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYE 184
E E N + + D L+K L++E L + + + ++
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-QLVSNL 1453
Query: 185 EKEQQLVNDCVKELRDANVQIASISE----ELAKKTEDAARQQEEITHLLSQIVDLQKKA 240
EK+Q+ + + E ++ + + A + E +K A + L +L++
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513
Query: 241 KACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNT 300
K E E+LV +L R LE + E L E ++EL+ + +
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 301 TSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSL 360
+ M +L + E ++ + E + + Q +ET + KQR+L
Sbjct: 1574 VN----------MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET--ELEDERKQRAL 1621
Score = 48.1 bits (113), Expect = 3e-05
Identities = 68/271 (25%), Positives = 121/271 (44%), Gaps = 65/271 (23%)
Query: 57 VTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDEL 116
V LL+ ++ E+ A+ + L+K K ER + E +++ + ++ SQL E ++ E
Sbjct: 848 VKPLLQVTRQEEEMQAK--EDELQKTK---ERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 117 LQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQL 176
LQ T E+E V L K ++LEE +L ++L
Sbjct: 903 LQAETELYAEAEEMRV---------------------RLAAKKQELEE---ILHEMEARL 938
Query: 177 KTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDL 236
+ E E++ QQL E + Q+ + E+L + E+AARQ+ Q+ +
Sbjct: 939 EEE----EDRGQQL----QAERKKMAQQMLDLEEQL--EEEEAARQK-------LQLEKV 981
Query: 237 QKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKT 296
+AK +E+E LV D +L+ E + LE++ ++ L E +E+ KNL
Sbjct: 982 TAEAKIKKLEDEILVM-----DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL---- 1032
Query: 297 MPNTTSRRYHSLGLFPMDSLAAEIEGTMRKE 327
T + H +S+ +E+E ++KE
Sbjct: 1033 ---TKLKNKH-------ESMISELEVRLKKE 1053
Score = 44.3 bits (103), Expect = 4e-04
Identities = 54/235 (22%), Positives = 105/235 (44%), Gaps = 34/235 (14%)
Query: 61 LEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFY 120
L+ EL A+ Q + K L E E QV+ +R++ +Q EL+ ++L QF
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT--EQLEQFK 1223
Query: 121 TSAAEESEPESVCSTPLKRNESSSSVQNYF---HLDSLQKKLKDLEEENVVLRSEASQLK 177
+ A L +N+ + +N L L + +++E + L ++ +L+
Sbjct: 1224 RAKAN-----------LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 178 TETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQ 237
++ E +L ND V +L++ ++ S++ L + A + +++ L SQ+ D Q
Sbjct: 1273 SKCSDGERARAEL-NDKVHKLQN---EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 238 KKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNL 292
+ + EE Q L ++ +LR+LE++ + L E E +NL
Sbjct: 1329 ELLQ------EETRQKLN--------VSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Score = 41.2 bits (95), Expect = 0.003
Identities = 69/371 (18%), Positives = 149/371 (40%), Gaps = 54/371 (14%)
Query: 18 QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQS 77
+D+ K H ++ LE QM + ++ + L+ E D +L +
Sbjct: 1527 KDDVGKNVHELEKSKRALET--------QMEEMKTQLEELEDELQATE-DAKLRLEVNMQ 1577
Query: 78 LLKKN--KTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCST 135
LK + L R+E EE+ ++ ++ + +E ++DE Q +AA + + E
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLHE--YETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 136 PLKRNESS--SSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVND 193
+ +S+ + L LQ ++KD + E R+ ++ E+K + L D
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695
Query: 194 CVKELRD----------ANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKAC 243
++ D A+++ ++EELA Q+E L ++I L+++ +
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 244 AVENEELVQHLGAAKDAQRQLTAEL--------------RELEDKYAECMEMLHEAQEEL 289
E + + A QL+ EL ++LE + E LHE + +
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815
Query: 290 KNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVR 349
K+ T + +++ A++E + +E + ++A + + + + + +
Sbjct: 1816 KSKFKST-------------IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI- 1861
Query: 350 NINQVVKQRSL 360
+ QV +R +
Sbjct: 1862 -LLQVEDERKM 1871
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 60.5 bits (145), Expect = 5e-09
Identities = 81/357 (22%), Positives = 149/357 (41%), Gaps = 53/357 (14%)
Query: 9 EEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDL 68
EEE Q E +K + D ++ LEE A + Q+ K VT + K+ +
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK-------VTAEAKIKKLED 992
Query: 69 ELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESE 128
E+ Q N L++ +LLEE++ + +++ + +L + S E E
Sbjct: 993 EILVMDDQ-----NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1047
Query: 129 PESVCSTPLKRNESSSSVQNYFHLDSLQKKLK----DLEEENVVLRSEASQLKTETITYE 184
LK+ E S L+ L++KL+ D E+ L+++ ++LK + E
Sbjct: 1048 ------VRLKKEEKSRQ-----ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 185 EKEQQLV----------NDCVKELRDANVQIASISEEL----------AKKTEDAARQQE 224
E+ Q + N+ +K++R+ I+ + E+L K+ D + E
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1156
Query: 225 EITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQ-RQLTAELRELEDKYAECMEMLH 283
+ L +D + + E+ V L A D + R A+++E+ K+A+ +E L
Sbjct: 1157 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1216
Query: 284 EAQEELKNLRNKTMPN--TTSRRYHSLG--LFPMDSLAAEIEGTMRK-ELQLEEAES 335
E E+ K + N T + L L + E+E +K E Q++E +S
Sbjct: 1217 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1273
Score = 53.1 bits (126), Expect = 8e-07
Identities = 59/278 (21%), Positives = 113/278 (40%), Gaps = 26/278 (9%)
Query: 18 QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQS 77
++ E+K + D L E++ AER + EKE ELA + S
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADL------------EKE---ELAEELASS 1727
Query: 78 LLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPL 137
L +N L + LE ++ + EE+ + + + + ++ T AE+ E
Sbjct: 1728 LSGRN-ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1786
Query: 138 KRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKE 197
+ S+ Q L+ KL ++E + S+ K+ E K QL +E
Sbjct: 1787 AQKNESARQQLERQNKELRSKLHEME------GAVKSKFKSTIAALEAKIAQLEEQVEQE 1840
Query: 198 LRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAA 257
R+ S+ ++ KK ++ Q E+ + Q + +K A ++L + L A
Sbjct: 1841 AREKQAATKSLKQK-DKKLKEILLQVEDERKMAEQYKEQAEKGNA---RVKQLKRQLEEA 1896
Query: 258 KDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNK 295
++ +++ A R+L+ + E E E+ L++K
Sbjct: 1897 EEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 50.8 bits (120), Expect = 4e-06
Identities = 80/363 (22%), Positives = 151/363 (41%), Gaps = 60/363 (16%)
Query: 46 QMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVE---HIREE 102
Q+T+ ++ A L++ + + A + L +K+ LTE LL+EQ++ + E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 103 VSQLRHELSMK----DELLQFYTSAAEESEPESVCSTPLKRN------------ESSSSV 146
++R L+ K +E+L + EE E ++ E +
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 147 QNYFHLDSL--QKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDA--- 201
+ L+ + + K+K LE+E +V+ + ++L E EE+ L + +E A
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1032
Query: 202 ----NVQIASISE-ELAKKTEDAARQQ----------------EEITHLLSQIVDLQKKA 240
N + ISE E+ K E+ +RQ+ E+I L +QI +L+ +
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ- 1091
Query: 241 KACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNT 300
A + EEL L D Q L+ K E + + QE+L + + N
Sbjct: 1092 --LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDS--ERAARNK 1143
Query: 301 TSRRYHSLGLFPMDSLAAEIEGTM-----RKELQLEEAESPDITHQKRVFETVRNINQVV 355
++ LG +++L E+E T+ ++EL+ + + + + ET + QV
Sbjct: 1144 AEKQKRDLG-EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 356 KQR 358
+ R
Sbjct: 1203 EMR 1205
Score = 50.8 bits (120), Expect = 4e-06
Identities = 95/466 (20%), Positives = 185/466 (39%), Gaps = 49/466 (10%)
Query: 29 HDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTER 88
H+ + LEE E GQ + A L E++ + E AAR Q L + T +
Sbjct: 932 HEMEARLEE---EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR--QKLQLEKVTAEAK 986
Query: 89 NELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQN 148
+ LE+++ + ++ ++L E + +E + T+ E E ++ T LK S +
Sbjct: 987 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046
Query: 149 YFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASI 208
L +K ++LE+ L +AS D +++ D QIA +
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDAS------------------DFHEQIADLQAQIAEL 1088
Query: 209 SEELAKKTED----AARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQ- 263
+LAKK E+ AR +EI + + +++ + E+L A A++Q
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 264 ---------LTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMD 314
L EL + D A E+ + ++E+ L+ T R H + M
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET---RSHEAQVQEMR 1205
Query: 315 SLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQ-- 372
A+ + ++L+ + ++ K+ E N + + R L + + +
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK-ENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 373 SSAMNSLLSSCVSTPRSSFYGSDIGNVV--LDNKTNSIILETEAADLGNDERSKKPGTPG 430
+ + L S C R+ +++ + V L N+ S+ A+ G + K
Sbjct: 1265 EAQVQELQSKCSDGERAR---AELNDKVHKLQNEVESVTGMLNEAE-GKAIKLAKDVASL 1320
Query: 431 TPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELR 476
+ D + L+ + ++ N ++ R EEE+ +L E+ E +
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1366
Score = 48.9 bits (115), Expect = 2e-05
Identities = 71/360 (19%), Positives = 140/360 (38%), Gaps = 29/360 (8%)
Query: 17 CQDEERKPTH---RQHDTQDLLEEV--LCAERVGQMTKTYNDIDAVTRLLEEKERDLELA 71
C D ER + H Q+ +E V + E G+ K D+ +++ L++ + L+
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334
Query: 72 ARIGQSLLKKNKTLTERNELLEEQVE-------HIREEVSQLRHELSMKDELLQFYTSAA 124
R ++ K + L E L++Q++ ++ +S L +LS + LQ + S
Sbjct: 1335 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1394
Query: 125 EESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYE 184
E E N + + D L+K L++E L + + + ++
Sbjct: 1395 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-QLVSNL 1453
Query: 185 EKEQQLVNDCVKELRDANVQIASISE----ELAKKTEDAARQQEEITHLLSQIVDLQKKA 240
EK+Q+ + + E ++ + + A + E +K A + L +L++
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513
Query: 241 KACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNT 300
K E E+LV +L R LE + E L E ++EL+ + +
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 301 TSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSL 360
+ M +L + E ++ + E + + Q +ET + KQR+L
Sbjct: 1574 VN----------MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET--ELEDERKQRAL 1621
Score = 48.1 bits (113), Expect = 3e-05
Identities = 68/271 (25%), Positives = 121/271 (44%), Gaps = 65/271 (23%)
Query: 57 VTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDEL 116
V LL+ ++ E+ A+ + L+K K ER + E +++ + ++ SQL E ++ E
Sbjct: 848 VKPLLQVTRQEEEMQAK--EDELQKTK---ERQQKAENELKELEQKHSQLTEEKNLLQEQ 902
Query: 117 LQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQL 176
LQ T E+E V L K ++LEE +L ++L
Sbjct: 903 LQAETELYAEAEEMRV---------------------RLAAKKQELEE---ILHEMEARL 938
Query: 177 KTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDL 236
+ E E++ QQL E + Q+ + E+L + E+AARQ+ Q+ +
Sbjct: 939 EEE----EDRGQQL----QAERKKMAQQMLDLEEQL--EEEEAARQK-------LQLEKV 981
Query: 237 QKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKT 296
+AK +E+E LV D +L+ E + LE++ ++ L E +E+ KNL
Sbjct: 982 TAEAKIKKLEDEILVM-----DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL---- 1032
Query: 297 MPNTTSRRYHSLGLFPMDSLAAEIEGTMRKE 327
T + H +S+ +E+E ++KE
Sbjct: 1033 ---TKLKNKH-------ESMISELEVRLKKE 1053
Score = 44.3 bits (103), Expect = 4e-04
Identities = 54/235 (22%), Positives = 105/235 (44%), Gaps = 34/235 (14%)
Query: 61 LEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFY 120
L+ EL A+ Q + K L E E QV+ +R++ +Q EL+ ++L QF
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT--EQLEQFK 1223
Query: 121 TSAAEESEPESVCSTPLKRNESSSSVQNYF---HLDSLQKKLKDLEEENVVLRSEASQLK 177
+ A L +N+ + +N L L + +++E + L ++ +L+
Sbjct: 1224 RAKAN-----------LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1272
Query: 178 TETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQ 237
++ E +L ND V +L++ ++ S++ L + A + +++ L SQ+ D Q
Sbjct: 1273 SKCSDGERARAEL-NDKVHKLQN---EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328
Query: 238 KKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNL 292
+ + EE Q L ++ +LR+LE++ + L E E +NL
Sbjct: 1329 ELLQ------EETRQKLN--------VSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Score = 41.2 bits (95), Expect = 0.003
Identities = 69/371 (18%), Positives = 149/371 (40%), Gaps = 54/371 (14%)
Query: 18 QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQS 77
+D+ K H ++ LE QM + ++ + L+ E D +L +
Sbjct: 1527 KDDVGKNVHELEKSKRALET--------QMEEMKTQLEELEDELQATE-DAKLRLEVNMQ 1577
Query: 78 LLKKN--KTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCST 135
LK + L R+E EE+ ++ ++ + +E ++DE Q +AA + + E
Sbjct: 1578 ALKGQFERDLQARDEQNEEKRRQLQRQLHE--YETELEDERKQRALAAAAKKKLEGDLKD 1635
Query: 136 PLKRNESS--SSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVND 193
+ +S+ + L LQ ++KD + E R+ ++ E+K + L D
Sbjct: 1636 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1695
Query: 194 CVKELRD----------ANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKAC 243
++ D A+++ ++EELA Q+E L ++I L+++ +
Sbjct: 1696 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1755
Query: 244 AVENEELVQHLGAAKDAQRQLTAEL--------------RELEDKYAECMEMLHEAQEEL 289
E + + A QL+ EL ++LE + E LHE + +
Sbjct: 1756 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815
Query: 290 KNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVR 349
K+ T + +++ A++E + +E + ++A + + + + + +
Sbjct: 1816 KSKFKST-------------IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI- 1861
Query: 350 NINQVVKQRSL 360
+ QV +R +
Sbjct: 1862 -LLQVEDERKM 1871
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 60.5 bits (145), Expect = 5e-09
Identities = 81/357 (22%), Positives = 149/357 (41%), Gaps = 53/357 (14%)
Query: 9 EEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDL 68
EEE Q E +K + D ++ LEE A + Q+ K VT + K+ +
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK-------VTAEAKIKKLED 985
Query: 69 ELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESE 128
E+ Q N L++ +LLEE++ + +++ + +L + S E E
Sbjct: 986 EILVMDDQ-----NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELE 1040
Query: 129 PESVCSTPLKRNESSSSVQNYFHLDSLQKKLK----DLEEENVVLRSEASQLKTETITYE 184
LK+ E S L+ L++KL+ D E+ L+++ ++LK + E
Sbjct: 1041 ------VRLKKEEKSRQ-----ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 185 EKEQQLV----------NDCVKELRDANVQIASISEEL----------AKKTEDAARQQE 224
E+ Q + N+ +K++R+ I+ + E+L K+ D + E
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELE 1149
Query: 225 EITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQ-RQLTAELRELEDKYAECMEMLH 283
+ L +D + + E+ V L A D + R A+++E+ K+A+ +E L
Sbjct: 1150 ALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT 1209
Query: 284 EAQEELKNLRNKTMPN--TTSRRYHSLG--LFPMDSLAAEIEGTMRK-ELQLEEAES 335
E E+ K + N T + L L + E+E +K E Q++E +S
Sbjct: 1210 EQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQS 1266
Score = 53.1 bits (126), Expect = 8e-07
Identities = 59/278 (21%), Positives = 113/278 (40%), Gaps = 26/278 (9%)
Query: 18 QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQS 77
++ E+K + D L E++ AER + EKE ELA + S
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADL------------EKE---ELAEELASS 1720
Query: 78 LLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPL 137
L +N L + LE ++ + EE+ + + + + ++ T AE+ E
Sbjct: 1721 LSGRN-ALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERST 1779
Query: 138 KRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKE 197
+ S+ Q L+ KL ++E + S+ K+ E K QL +E
Sbjct: 1780 AQKNESARQQLERQNKELRSKLHEME------GAVKSKFKSTIAALEAKIAQLEEQVEQE 1833
Query: 198 LRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAA 257
R+ S+ ++ KK ++ Q E+ + Q + +K A ++L + L A
Sbjct: 1834 AREKQAATKSLKQK-DKKLKEILLQVEDERKMAEQYKEQAEKGNA---RVKQLKRQLEEA 1889
Query: 258 KDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNK 295
++ +++ A R+L+ + E E E+ L++K
Sbjct: 1890 EEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 50.8 bits (120), Expect = 4e-06
Identities = 80/363 (22%), Positives = 151/363 (41%), Gaps = 60/363 (16%)
Query: 46 QMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVE---HIREE 102
Q+T+ ++ A L++ + + A + L +K+ LTE LL+EQ++ + E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 103 VSQLRHELSMK----DELLQFYTSAAEESEPESVCSTPLKRN------------ESSSSV 146
++R L+ K +E+L + EE E ++ E +
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 147 QNYFHLDSL--QKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDA--- 201
+ L+ + + K+K LE+E +V+ + ++L E EE+ L + +E A
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL 1025
Query: 202 ----NVQIASISE-ELAKKTEDAARQQ----------------EEITHLLSQIVDLQKKA 240
N + ISE E+ K E+ +RQ+ E+I L +QI +L+ +
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ- 1084
Query: 241 KACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNT 300
A + EEL L D Q L+ K E + + QE+L + + N
Sbjct: 1085 --LAKKEEELQAALARLDDEIAQKNNALK----KIRELEGHISDLQEDLDS--ERAARNK 1136
Query: 301 TSRRYHSLGLFPMDSLAAEIEGTM-----RKELQLEEAESPDITHQKRVFETVRNINQVV 355
++ LG +++L E+E T+ ++EL+ + + + + ET + QV
Sbjct: 1137 AEKQKRDLG-EELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 356 KQR 358
+ R
Sbjct: 1196 EMR 1198
Score = 50.8 bits (120), Expect = 4e-06
Identities = 95/466 (20%), Positives = 185/466 (39%), Gaps = 49/466 (10%)
Query: 29 HDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTER 88
H+ + LEE E GQ + A L E++ + E AAR Q L + T +
Sbjct: 925 HEMEARLEE---EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR--QKLQLEKVTAEAK 979
Query: 89 NELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQN 148
+ LE+++ + ++ ++L E + +E + T+ E E ++ T LK S +
Sbjct: 980 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039
Query: 149 YFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASI 208
L +K ++LE+ L +AS D +++ D QIA +
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDAS------------------DFHEQIADLQAQIAEL 1081
Query: 209 SEELAKKTED----AARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQ- 263
+LAKK E+ AR +EI + + +++ + E+L A A++Q
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 264 ---------LTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMD 314
L EL + D A E+ + ++E+ L+ T R H + M
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET---RSHEAQVQEMR 1198
Query: 315 SLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQ-- 372
A+ + ++L+ + ++ K+ E N + + R L + + +
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK-ENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 373 SSAMNSLLSSCVSTPRSSFYGSDIGNVV--LDNKTNSIILETEAADLGNDERSKKPGTPG 430
+ + L S C R+ +++ + V L N+ S+ A+ G + K
Sbjct: 1258 EAQVQELQSKCSDGERAR---AELNDKVHKLQNEVESVTGMLNEAE-GKAIKLAKDVASL 1313
Query: 431 TPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAEKGELR 476
+ D + L+ + ++ N ++ R EEE+ +L E+ E +
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAK 1359
Score = 48.9 bits (115), Expect = 2e-05
Identities = 71/360 (19%), Positives = 140/360 (38%), Gaps = 29/360 (8%)
Query: 17 CQDEERKPTH---RQHDTQDLLEEV--LCAERVGQMTKTYNDIDAVTRLLEEKERDLELA 71
C D ER + H Q+ +E V + E G+ K D+ +++ L++ + L+
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327
Query: 72 ARIGQSLLKKNKTLTERNELLEEQVE-------HIREEVSQLRHELSMKDELLQFYTSAA 124
R ++ K + L E L++Q++ ++ +S L +LS + LQ + S
Sbjct: 1328 TRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTV 1387
Query: 125 EESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYE 184
E E N + + D L+K L++E L + + + ++
Sbjct: 1388 EALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQR-QLVSNL 1446
Query: 185 EKEQQLVNDCVKELRDANVQIASISE----ELAKKTEDAARQQEEITHLLSQIVDLQKKA 240
EK+Q+ + + E ++ + + A + E +K A + L +L++
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1506
Query: 241 KACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNT 300
K E E+LV +L R LE + E L E ++EL+ + +
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 301 TSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSL 360
+ M +L + E ++ + E + + Q +ET + KQR+L
Sbjct: 1567 VN----------MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYET--ELEDERKQRAL 1614
Score = 48.1 bits (113), Expect = 3e-05
Identities = 68/271 (25%), Positives = 121/271 (44%), Gaps = 65/271 (23%)
Query: 57 VTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDEL 116
V LL+ ++ E+ A+ + L+K K ER + E +++ + ++ SQL E ++ E
Sbjct: 841 VKPLLQVTRQEEEMQAK--EDELQKTK---ERQQKAENELKELEQKHSQLTEEKNLLQEQ 895
Query: 117 LQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQL 176
LQ T E+E V L K ++LEE +L ++L
Sbjct: 896 LQAETELYAEAEEMRV---------------------RLAAKKQELEE---ILHEMEARL 931
Query: 177 KTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDL 236
+ E E++ QQL E + Q+ + E+L + E+AARQ+ Q+ +
Sbjct: 932 EEE----EDRGQQL----QAERKKMAQQMLDLEEQL--EEEEAARQK-------LQLEKV 974
Query: 237 QKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKT 296
+AK +E+E LV D +L+ E + LE++ ++ L E +E+ KNL
Sbjct: 975 TAEAKIKKLEDEILVM-----DDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNL---- 1025
Query: 297 MPNTTSRRYHSLGLFPMDSLAAEIEGTMRKE 327
T + H +S+ +E+E ++KE
Sbjct: 1026 ---TKLKNKH-------ESMISELEVRLKKE 1046
Score = 44.3 bits (103), Expect = 4e-04
Identities = 54/235 (22%), Positives = 105/235 (44%), Gaps = 34/235 (14%)
Query: 61 LEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFY 120
L+ EL A+ Q + K L E E QV+ +R++ +Q EL+ ++L QF
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELT--EQLEQFK 1216
Query: 121 TSAAEESEPESVCSTPLKRNESSSSVQNYF---HLDSLQKKLKDLEEENVVLRSEASQLK 177
+ A L +N+ + +N L L + +++E + L ++ +L+
Sbjct: 1217 RAKAN-----------LDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQ 1265
Query: 178 TETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQ 237
++ E +L ND V +L++ ++ S++ L + A + +++ L SQ+ D Q
Sbjct: 1266 SKCSDGERARAEL-NDKVHKLQN---EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321
Query: 238 KKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNL 292
+ + EE Q L ++ +LR+LE++ + L E E +NL
Sbjct: 1322 ELLQ------EETRQKLN--------VSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Score = 41.2 bits (95), Expect = 0.003
Identities = 69/371 (18%), Positives = 149/371 (40%), Gaps = 54/371 (14%)
Query: 18 QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQS 77
+D+ K H ++ LE QM + ++ + L+ E D +L +
Sbjct: 1520 KDDVGKNVHELEKSKRALET--------QMEEMKTQLEELEDELQATE-DAKLRLEVNMQ 1570
Query: 78 LLKKN--KTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCST 135
LK + L R+E EE+ ++ ++ + +E ++DE Q +AA + + E
Sbjct: 1571 ALKGQFERDLQARDEQNEEKRRQLQRQLHE--YETELEDERKQRALAAAAKKKLEGDLKD 1628
Query: 136 PLKRNESS--SSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVND 193
+ +S+ + L LQ ++KD + E R+ ++ E+K + L D
Sbjct: 1629 LELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEAD 1688
Query: 194 CVKELRD----------ANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKAC 243
++ D A+++ ++EELA Q+E L ++I L+++ +
Sbjct: 1689 LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEE 1748
Query: 244 AVENEELVQHLGAAKDAQRQLTAEL--------------RELEDKYAECMEMLHEAQEEL 289
E + + A QL+ EL ++LE + E LHE + +
Sbjct: 1749 QGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808
Query: 290 KNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVR 349
K+ T + +++ A++E + +E + ++A + + + + + +
Sbjct: 1809 KSKFKST-------------IAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEI- 1854
Query: 350 NINQVVKQRSL 360
+ QV +R +
Sbjct: 1855 -LLQVEDERKM 1864
>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
sapiens]
Length = 693
Score = 60.1 bits (144), Expect = 7e-09
Identities = 75/324 (23%), Positives = 135/324 (41%), Gaps = 57/324 (17%)
Query: 60 LLEEKERDLELAARIGQSLLKKNKTLTERNEL-----------LEEQVEHIREEVSQLRH 108
L EEK+RD+ + +SL + + E L L+++ +H+R+EV L
Sbjct: 257 LKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEG 316
Query: 109 ELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHL----DSLQKKLKDLEE 164
+L + E Q + ++E + + R + + V+ L + L+++ K L+E
Sbjct: 317 KLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQE 376
Query: 165 ENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQE 224
+ LR + +L+ + ++E++L K L D E L KK E +Q+E
Sbjct: 377 QGERLRKQEQRLRKQEERLRKEEERLQKQ-EKRLWDQ-------EERLWKKEERLQKQEE 428
Query: 225 EITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHE 284
+ + +D Q C+ E+ L K + QL +++EL++K L E
Sbjct: 429 RLALSQNHKLDKQLAEPQCSFED------LNNEKKSALQLEQQVKELQEK-------LDE 475
Query: 285 AQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRV 344
E + RN+ + S +A EG + L EE E+P T
Sbjct: 476 EHLEAASQRNQQLETQLS------------LVALPGEGDGGQHLDSEEEEAPRPT----- 518
Query: 345 FETVRNINQVVKQRSLTPSPMNIP 368
NI + ++ R T S M++P
Sbjct: 519 ----PNIPEDLESREATSSFMDLP 538
>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
isoform 1 [Homo sapiens]
Length = 693
Score = 60.1 bits (144), Expect = 7e-09
Identities = 75/324 (23%), Positives = 135/324 (41%), Gaps = 57/324 (17%)
Query: 60 LLEEKERDLELAARIGQSLLKKNKTLTERNEL-----------LEEQVEHIREEVSQLRH 108
L EEK+RD+ + +SL + + E L L+++ +H+R+EV L
Sbjct: 257 LKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEG 316
Query: 109 ELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHL----DSLQKKLKDLEE 164
+L + E Q + ++E + + R + + V+ L + L+++ K L+E
Sbjct: 317 KLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQE 376
Query: 165 ENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQE 224
+ LR + +L+ + ++E++L K L D E L KK E +Q+E
Sbjct: 377 QGERLRKQEQRLRKQEERLRKEEERLQKQ-EKRLWDQ-------EERLWKKEERLQKQEE 428
Query: 225 EITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHE 284
+ + +D Q C+ E+ L K + QL +++EL++K L E
Sbjct: 429 RLALSQNHKLDKQLAEPQCSFED------LNNEKKSALQLEQQVKELQEK-------LDE 475
Query: 285 AQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRV 344
E + RN+ + S +A EG + L EE E+P T
Sbjct: 476 EHLEAASQRNQQLETQLS------------LVALPGEGDGGQHLDSEEEEAPRPT----- 518
Query: 345 FETVRNINQVVKQRSLTPSPMNIP 368
NI + ++ R T S M++P
Sbjct: 519 ----PNIPEDLESREATSSFMDLP 538
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 59.7 bits (143), Expect = 9e-09
Identities = 77/338 (22%), Positives = 145/338 (42%), Gaps = 49/338 (14%)
Query: 39 LCAERVGQMTKTYNDID----AVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEE 94
+ A++V ++ + ++D + + LEE E D+E + + L ++ L E + L E
Sbjct: 1692 ILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAE 1751
Query: 95 QVEHI---REEVSQLRHELSMKDELL-QFYTSAAEESE--PESVCSTPLKRNESSSSVQN 148
+ E + RE++S+ +L+ ++ELL Q A+ E PE KR +
Sbjct: 1752 EEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQL------ 1805
Query: 149 YFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASI 208
++KK+K ++ + S K + I Y++K L +A
Sbjct: 1806 ------IEKKMKLAQKRERWINSMEELTKNKMILYQKKN----------LAQEKKNLAQE 1849
Query: 209 SEELAKKTEDAARQQEEITHLLSQIVDLQKKA----KACAVENEELVQHLGAA---KDAQ 261
E+LA++ E+ +E +TH Q+V ++ K K A E+L Q K+
Sbjct: 1850 KEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQEKETVIKKKEKL 1909
Query: 262 RQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGL--------FPM 313
+ +L ++ED A+ E L AQE++K K M R L + M
Sbjct: 1910 AETEKKLVQVEDSLAKKQEKL--AQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLEM 1967
Query: 314 DSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNI 351
LA E + + L + E+P+ + Q+++ + + +
Sbjct: 1968 KRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQEL 2005
Score = 39.3 bits (90), Expect = 0.012
Identities = 54/264 (20%), Positives = 115/264 (43%), Gaps = 27/264 (10%)
Query: 60 LLEEKERDLELAARIGQSLL----KKNKTLTERNELLEEQV----EHIREEVSQLRHELS 111
L E+K+ E ++ +++L K+ + E LEE+V E ++V++ + +
Sbjct: 1510 LQEDKKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQ 1569
Query: 112 MKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRS 171
+ + + + A + + L + E + + L ++ + L + V +
Sbjct: 1570 EEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEER----QLAQEERKLAQAYVKITQ 1625
Query: 172 EASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQE------- 224
+ ++ + +KE+ L K ++A ++A ++LAKK E AR++E
Sbjct: 1626 DDREMAQAEGKFAQKEETLAQRGEKLSQEAE-KLAQKRKKLAKKWEKVAREEEKLAKKGG 1684
Query: 225 ---EITHLLSQ-IVDLQKKAKACAVENEELVQHLGAAKDAQRQLT---AELRELEDKYAE 277
E+ ++L+Q + +L ++ + + +EL Q L + +L+ EL + E K E
Sbjct: 1685 KLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVE 1744
Query: 278 CMEMLHEAQEELKNLRNKTMPNTT 301
+ L E +E L R K T
Sbjct: 1745 EKKKLAEEEEALAWQREKLSEEET 1768
Score = 37.4 bits (85), Expect = 0.047
Identities = 68/360 (18%), Positives = 136/360 (37%), Gaps = 46/360 (12%)
Query: 9 EEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDL 68
E+E FE EE+ H E+ + A ++ K + R+ + +R L
Sbjct: 2002 EQELFERKLSLEEKILLH---------EDRILAMEESEIAKGKLEFTRGQRIFVQGQRKL 2052
Query: 69 ELAARIGQSLLKKNKTLTER----NELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAA 124
A+R L+KK ++L++ N++L+ + R+E + E+ M
Sbjct: 2053 AKASR---KLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKM------------ 2097
Query: 125 EESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYE 184
T +KR + L K D E+ L + +L +
Sbjct: 2098 ----------TKMKRALFVKERRLSIEQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLA 2147
Query: 185 EKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACA 244
K ++++N K + + SE + E+ ++EE+ L + +K+AK
Sbjct: 2148 NKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGD 2207
Query: 245 VENEEL---VQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTT 301
E+ V + + + ++ + L ELE + + E E +EE + +
Sbjct: 2208 KPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEE 2267
Query: 302 SRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVKQRSLT 361
R+ G + E E +K+ + +E + ++ ++ VFE I + SL+
Sbjct: 2268 ERKEEEEG----EEKQVEKEEEEKKK-KKKEKKKEEVQEKEEVFEEKEEIMSEEETESLS 2322
Score = 36.6 bits (83), Expect = 0.079
Identities = 41/190 (21%), Positives = 78/190 (41%), Gaps = 16/190 (8%)
Query: 94 EQVEHIREEVSQLRHELSMKDELL---QFYTSAAEESEPESVCSTPLKRNESSSSVQNYF 150
E EH EE+ L EL ++ L + EE E E V +R E +
Sbjct: 2221 ESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQV 2280
Query: 151 HLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASIS- 209
+ +KK K E+ + E Q K E +EEKE+ + + + L D + S S
Sbjct: 2281 EKEEEEKKKKKKEK-----KKEEVQEKEE--VFEEKEEIMSEEETESLSDEEEEEESCSL 2333
Query: 210 EELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAV-----ENEELVQHLGAAKDAQRQL 264
EE + ++ +++++ + L+ + + ++ + LG K ++L
Sbjct: 2334 EEEVDREKEILKKEKQFKLQEQRRKSLRGRERVLSILRGVPHGKGRAIRLGVLKSPLKKL 2393
Query: 265 TAELRELEDK 274
+ E+++K
Sbjct: 2394 MSTALEMKEK 2403
>gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo
sapiens]
Length = 693
Score = 59.7 bits (143), Expect = 9e-09
Identities = 74/324 (22%), Positives = 135/324 (41%), Gaps = 57/324 (17%)
Query: 60 LLEEKERDLELAARIGQSLLKKNKTLTERNEL-----------LEEQVEHIREEVSQLRH 108
L EEK+RD+ + +SL + + E L L+++ +H+R+EV L
Sbjct: 257 LKEEKKRDIHRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEG 316
Query: 109 ELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHL----DSLQKKLKDLEE 164
+L + E Q + ++E + + R + + V+ L + L+++ K L+E
Sbjct: 317 KLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQE 376
Query: 165 ENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQE 224
+ LR + +L+ + ++E++L K L D E L KK E +Q+E
Sbjct: 377 QGERLRKQEQRLRKQEERLRKEEERLQKQ-EKRLWDQ-------EERLWKKEERLQKQEE 428
Query: 225 EITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHE 284
+ + +D Q C+ E+ L K + QL +++EL++K E E L
Sbjct: 429 RLALSQNHKLDKQLAEPQCSFED------LNNEKKSALQLEQQVKELQEKLDE--EHLEA 480
Query: 285 AQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRV 344
A + + L + + +A EG + L EE E+P T
Sbjct: 481 ASHQNQQLETQ-----------------LSLVALPGEGDGGQHLDSEEEEAPRPT----- 518
Query: 345 FETVRNINQVVKQRSLTPSPMNIP 368
NI + ++ R T S M++P
Sbjct: 519 ----PNIPEDLESREATSSFMDLP 538
>gi|157502225 Janus kinase and microtubule interacting protein 3
[Homo sapiens]
Length = 844
Score = 59.3 bits (142), Expect = 1e-08
Identities = 83/302 (27%), Positives = 138/302 (45%), Gaps = 45/302 (14%)
Query: 32 QDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELA-ARIGQSL--LKKNKTLTER 88
Q+ + L AER KT + A + + + DLE A A GQ + +++ + L R
Sbjct: 520 QEQVGGTLDAERE---VKTREQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRR 576
Query: 89 NELLEEQVEHIREEVSQLRHELS---MKDELLQFYTSAAEESEPESVC----STPLKRNE 141
N+ L E+++ + E ++LRHE+ ++ELL+F EE E +S TP +
Sbjct: 577 NQELVEKIKQMETEEARLRHEVQDARDQNELLEFRILELEERERKSPAISFHHTPFV--D 634
Query: 142 SSSSVQNYFHLD--------SLQKKLKDLEEENVVLRSEAS----QLKTETITYEEKEQQ 189
S +Q Y + L KKL D+ +N L +E Q +T +T EK Q
Sbjct: 635 GKSPLQVYCEAEGVTDIVVAELMKKL-DILGDNANLTNEEQVVVIQART-VLTLAEKWLQ 692
Query: 190 LVNDCVKELRDANVQIAS-----------ISEELAKKTEDAARQQEEITHLLSQIVD-LQ 237
+ + L+ V + S + EEL + + + + I L + + D LQ
Sbjct: 693 QIEETEAALQRKMVDLESEKELFSKQKGYLDEELDYRKQALDQANKHILELEAMLYDALQ 752
Query: 238 KKAKACAVE---NEELVQHLGAAKDAQRQLTAELRELEDK-YAECMEMLHEAQEELKNLR 293
++A A E EE + A + +RQ+ +ELRE + + E ME+L AQ+ +K L
Sbjct: 753 QEAGAKVAELLSEEEREKLKVAVEQWKRQVMSELRERDAQILRERMELLQLAQQRIKELE 812
Query: 294 NK 295
+
Sbjct: 813 ER 814
Score = 32.7 bits (73), Expect = 1.1
Identities = 62/288 (21%), Positives = 115/288 (39%), Gaps = 41/288 (14%)
Query: 16 DCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIG 75
D D P +Q D +D L ++ +++ ++ LL E+ +L R
Sbjct: 275 DASDHSGSP-EQQLDEKDARRFQL---KIAELSAIIRKLEDRNALLSEERNELLKRVREA 330
Query: 76 QS----LLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSA-AEESEPE 130
+S LL KNK L+ +NE L H L + L+F T E +
Sbjct: 331 ESQYKPLLDKNKRLSRKNE--------------DLSHALRRMENKLKFVTQENIEMRQRA 376
Query: 131 SVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQL 190
+ P N+ S Q+ +D L KL+ +E++N++ +L T + L
Sbjct: 377 GIIRRPSSLNDLDQS-QDEREVDFL--KLQIVEQQNLI-----DELSKTLETAGYVKSVL 428
Query: 191 VNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQI-VDLQKKAKACAVENEE 249
D + R ++A + + + +T ++ + S + + + +++
Sbjct: 429 ERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTDRTDQTPCTPDDD 488
Query: 250 LVQHLGAAKDAQ----RQLTAELRELEDKYAECMEMLH---EAQEELK 290
L + G AK+ RQLT E + L+ YA E + +A+ E+K
Sbjct: 489 LEE--GMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVK 534
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 59.3 bits (142), Expect = 1e-08
Identities = 83/371 (22%), Positives = 164/371 (44%), Gaps = 48/371 (12%)
Query: 9 EEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERV--GQMTKTYNDIDAVTRLLEEKER 66
E FE Q+ + T Q + Q ++ V A+ V G++ ++D R E+ER
Sbjct: 770 ESSLFEAQQQNSVIEVTKGQLEVQ--IQTVTQAKEVIQGEVRCLKLELDT-ERSQAEQER 826
Query: 67 D-----LELAARIGQSLLKKNKTLTER--NELLE----EQVEHIRE--------EVSQLR 107
D L A + G++ L++ K E+ N+L E E+ H +E E ++
Sbjct: 827 DAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKME 886
Query: 108 HELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENV 167
E+ +K++ + A+ E + + L + + + + L++L + K+L + +
Sbjct: 887 LEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQ 946
Query: 168 VLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEIT 227
L +K + + KEQ+ +L++A ++ E + +D A QEE +
Sbjct: 947 QLERLRQDMKVQKL----KEQETTGILQTQLQEAQREL---KEAARQHRDDLAALQEESS 999
Query: 228 HLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQE 287
LL +DLQK+ E+L L A D+QR + +E+++K E E + Q+
Sbjct: 1000 SLLQDKMDLQKQV-------EDLKSQLVAQDDSQRLVE---QEVQEKLRETQE-YNRIQK 1048
Query: 288 ELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRVFET 347
EL+ + + + L L DS+ + +R+++Q + E +++ Q +
Sbjct: 1049 ELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMEL--- 1105
Query: 348 VRNINQVVKQR 358
+ Q VK++
Sbjct: 1106 ---LRQEVKEK 1113
Score = 46.2 bits (108), Expect = 1e-04
Identities = 70/296 (23%), Positives = 131/296 (44%), Gaps = 53/296 (17%)
Query: 18 QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAAR---- 73
++E+++ H ++ L+E+L Q +++ +++ + LE + EL +
Sbjct: 507 KEEQQEELHLAVRERERLQEMLMGLEAKQ-SESLSELITLREALESSHLEGELLRQEQTE 565
Query: 74 IGQSLLKKNKTLTERNELLEEQVEHIREEVSQLR---------------HELSMKDELLQ 118
+ +L + +++ E L ++ EV+ LR ++ + +LLQ
Sbjct: 566 VTAALARAEQSIAE----LSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQ 621
Query: 119 FYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKT 178
E E +SVCS R E++ +N +LQ L + E+ L + + L+
Sbjct: 622 L------EEENQSVCS----RMEAAEQARN-----ALQVDLAEAEKRREALWEKNTHLEA 666
Query: 179 ETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQI---VD 235
+ EE +L D LRD I EE+ KK ++ QQE T L Q+
Sbjct: 667 QLQKAEEAGAELQAD----LRD----IQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAK 718
Query: 236 LQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKN 291
Q++ A AV+ +E + AA + +L A R+ +D AE ++ L A+E L++
Sbjct: 719 RQEEVLARAVQEKEALVREKAALEV--RLQAVERDRQD-LAEQLQGLSSAKELLES 771
Score = 45.1 bits (105), Expect = 2e-04
Identities = 65/297 (21%), Positives = 129/297 (43%), Gaps = 39/297 (13%)
Query: 43 RVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREE 102
+V Q ++ +T+ L E+E ++E Q L K+ + ELL ++ +E
Sbjct: 1412 KVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQE 1471
Query: 103 VSQLRHELSMKDE---LLQFYTSAAEESEPE-SVCSTPLKRNESSSSVQNYFHLDSLQKK 158
V + ++ ++ +L+ A +E E + +V ++ E Q + L+ +
Sbjct: 1472 VDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQR----NVLEHQ 1527
Query: 159 LKDLEEENVVLRSEASQLKT--------ETITYEEKEQQLVNDCVKEL-RDANVQIASIS 209
L +LE+++ ++ S+ Q++ E + E +E +C ++L ++ Q +
Sbjct: 1528 LLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQR 1587
Query: 210 EELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAK----DAQRQ-- 263
L T D + +E+ SQI DL+ + A E +E Q + + + + QRQ
Sbjct: 1588 VALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKE 1647
Query: 264 -LTAELRE--------------LEDKYAECMEMLHEAQEELK-NLRNKTMPNTTSRR 304
LT +L LED+ ++L E E++K +LR + TT R+
Sbjct: 1648 HLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQ 1704
Score = 45.1 bits (105), Expect = 2e-04
Identities = 69/371 (18%), Positives = 148/371 (39%), Gaps = 38/371 (10%)
Query: 1 MSLRDKGGEEECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRL 60
+ L ++ E + D E T + Q+ +EV Q+ + + +T+
Sbjct: 1595 LDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQRE--QIEELQRQKEHLTQD 1652
Query: 61 LEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFY 120
LE ++++L L Q L + T + ++LEE +E I+ + + EL+ + +L+Q
Sbjct: 1653 LERRDQELMLQKERIQVLEDQR---TRQTKILEEDLEQIKLSLRERGRELTTQRQLMQER 1709
Query: 121 T------SAAEESEPESVCSTPLKRNESSSSVQNYFH-----LDSLQKKLKDL------- 162
S A+ E + + + Q + H D L+++L+ L
Sbjct: 1710 AEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGET 1769
Query: 163 -------EEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKK 215
E+E VVL+ + + + + E+ Q +++ + L + ++ E L ++
Sbjct: 1770 SLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQEL----EALQQE 1825
Query: 216 TEDAARQQEEITHLLSQIVDLQKKAKACAVENE-ELVQHLGAAKDAQRQLTAELRELEDK 274
+ A Q+E + + ++A E EL H A+ + +L E R ++
Sbjct: 1826 QQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQAL 1885
Query: 275 YAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMR---KELQLE 331
++ E++E+ K L + H + + + + ++ +EL+
Sbjct: 1886 EEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEAL 1945
Query: 332 EAESPDITHQK 342
AES HQ+
Sbjct: 1946 RAESQSSRHQE 1956
Score = 44.3 bits (103), Expect = 4e-04
Identities = 62/292 (21%), Positives = 117/292 (40%), Gaps = 60/292 (20%)
Query: 55 DAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKD 114
+AV L + +DL + L + + L ER E + + E+ L+ +LS
Sbjct: 1239 EAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQ 1298
Query: 115 ELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQK----------------- 157
E + E + S+ S ++ +E+ +S+Q+ LQ+
Sbjct: 1299 E-----EKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENL 1353
Query: 158 --KLKDLEEENVVLRSEAS----------------QLKTETITYEEKEQQLVNDCVKELR 199
+++ L+ V R++AS +LK E + E + Q + + EL+
Sbjct: 1354 TAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQE-QGELK 1412
Query: 200 DANVQIASISEELAKKTEDAARQQEEITHLLSQIVDL--QKKAKACAVE----------- 246
A Q ++ E LA T+ A ++EE+ L QI +L Q++ + A+E
Sbjct: 1413 VA--QGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQ 1470
Query: 247 ----NEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRN 294
+E +Q L + L ++E E K E + E +++ + RN
Sbjct: 1471 EVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRN 1522
Score = 42.7 bits (99), Expect = 0.001
Identities = 79/364 (21%), Positives = 146/364 (40%), Gaps = 92/364 (25%)
Query: 14 EYDCQDEERKPT-------HRQHDTQDLLEEVL-CAERVGQMTKTYNDIDAVTRLLEEK- 64
++D QD ++ T R+ QDL +++ C E V + + ++ + + L ++
Sbjct: 378 QFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRL 437
Query: 65 -----ERD------LELAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRH---EL 110
ERD ++L + SL K+ + L + E L +Q+E + +E +LR EL
Sbjct: 438 QKLTGERDTLAGQTVDLQGEV-DSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVEL 496
Query: 111 SM--------KDELLQFYTSAAEESE--PESVCSTPLKRNESSSSVQNYFHLDSLQKKLK 160
+ K+E + A E E E + K++ES S L +L++ L+
Sbjct: 497 QLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSE------LITLREALE 550
Query: 161 DLEEENVVLRSEASQLKTETITYEEKEQQL------VNDCVKELRDANVQIASISEELAK 214
E +LR E +++ E+ +L + V +LR A V++++++E LA
Sbjct: 551 SSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALAL 610
Query: 215 --------------------KTEDAARQQ-------------------EEITHLLSQI-- 233
+AA Q E+ THL +Q+
Sbjct: 611 DKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQK 670
Query: 234 -----VDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEE 288
+LQ + E EE+ + L ++ Q T +L +L + E+L A +E
Sbjct: 671 AEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQE 730
Query: 289 LKNL 292
+ L
Sbjct: 731 KEAL 734
Score = 40.8 bits (94), Expect = 0.004
Identities = 62/297 (20%), Positives = 128/297 (43%), Gaps = 37/297 (12%)
Query: 11 ECFEYDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLE- 69
EC + ++ H+ Q L++E+ ++ T+ +D LEE+ ++L+
Sbjct: 1556 ECLALELEENH----HKMECQQKLIKELEGQRETQRVALTHLTLD-----LEERSQELQA 1606
Query: 70 -------------LAARIGQSLLKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDEL 116
+ AR Q ++ K+ E+ E L+ Q EH+ +++ + EL ++ E
Sbjct: 1607 QSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKER 1666
Query: 117 LQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQL 176
+Q + + + L++ + S + Q + EE +++ L
Sbjct: 1667 IQVLED--QRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSL 1724
Query: 177 KTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQ---- 232
+ + +KE+++ +C +E ++ + ++L ++ + R+ E + LLSQ
Sbjct: 1725 EHMKLILRDKEKEV--ECQQEHIH---ELQELKDQLEQQLQGLHRKVGETSLLLSQREQE 1779
Query: 233 IVDLQKKAKACAVENEELVQHLGAAKD-AQRQLTAELRELEDKYAECMEMLHEAQEE 288
IV LQ++ + + E Q L + D AQR L +ELE E + + QEE
Sbjct: 1780 IVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQE--QQQAQGQEE 1834
Score = 40.4 bits (93), Expect = 0.005
Identities = 76/389 (19%), Positives = 148/389 (38%), Gaps = 44/389 (11%)
Query: 28 QHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTE 87
Q Q LLE+ + + T T + A + R LE A RI +
Sbjct: 1978 QGKEQHLLEQAELSRSLEASTAT---LQASLDACQAHSRQLEEALRI------------Q 2022
Query: 88 RNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQ 147
E+ ++ + + +E+V QL+ L+ +DE L+ + E E + L + + +Q
Sbjct: 2023 EGEIQDQDLRY-QEDVQQLQQALAQRDEELR------HQQEREQLLEKSLAQRVQENMIQ 2075
Query: 148 NYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDA----NV 203
+K+ E E +R ++ +T +KEQ+++ ELR+ N+
Sbjct: 2076 --------EKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEIL-----ELRETQQRNNL 2122
Query: 204 QIASISEELAKKTEDAARQQEEITHLLSQIVDLQ---KKAKACAVENEELVQHLGAAKDA 260
+ S + + E + + L ++ LQ ++ +A +E E Q L +
Sbjct: 2123 EALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQ 2182
Query: 261 QRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEI 320
+ + L+E+ + Q+ L++ T R HS G L +
Sbjct: 2183 TKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRG 2242
Query: 321 E-GTMRKELQLEEAE-SPDITHQKRVFETVRNINQVVKQRSLTPSPMNIPGSNQSSAMNS 378
E G E+ EAE SPD ++ + + ++ Q V + + S + S +
Sbjct: 2243 EQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ 2302
Query: 379 LLSSCVSTPRSSFYGSDIGNVVLDNKTNS 407
+ R + + G++ + T S
Sbjct: 2303 VERERRKLKREAMRAAQAGSLEISKATAS 2331
Score = 38.9 bits (89), Expect = 0.016
Identities = 67/304 (22%), Positives = 127/304 (41%), Gaps = 25/304 (8%)
Query: 62 EEKERDLELAARIGQSLLKKNKTL-TERNELLEEQVEHIRE--EVSQLRHELSMKDE--- 115
EE++ +L LA R + L + L +++E L E + +RE E S L EL +++
Sbjct: 508 EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELIT-LREALESSHLEGELLRQEQTEV 566
Query: 116 ---LLQFYTSAAEESEPESVCSTPLKRNESS----SSVQNYFHLDS--LQKKLKDLEEEN 166
L + S AE S E+ T + ++ S++ LD L ++L LEEEN
Sbjct: 567 TAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEEN 626
Query: 167 --VVLRSEASQLKTETITYEEKEQQLVNDCVKELRD-ANVQIASISEELAKKTEDAARQQ 223
V R EA++ + + E + + + E Q+ E A+ D Q
Sbjct: 627 QSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQ 686
Query: 224 EEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLH 283
EE + ++ + + + +A + E+L Q ++ + E L + A L
Sbjct: 687 EEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQ 746
Query: 284 EAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTM-RKELQLEEAESPDITHQK 342
+ + ++L + ++++ LF + IE T + E+Q++ +T K
Sbjct: 747 AVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQ-----TVTQAK 801
Query: 343 RVFE 346
V +
Sbjct: 802 EVIQ 805
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 59.3 bits (142), Expect = 1e-08
Identities = 74/367 (20%), Positives = 156/367 (42%), Gaps = 43/367 (11%)
Query: 18 QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQS 77
Q E++ + + + DL A + ++K +++ + R LE++ +++ Q
Sbjct: 1219 QKLEKEKSEMKMEIDDL------ASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQR 1272
Query: 78 LLKKNKTLTERNELLEEQVEHIREE------VSQL-RHELSMKDELLQFYTSAAEESEPE 130
L+ N +R L E E+ R+ VSQL R + + ++ + EE + +
Sbjct: 1273 LI--NDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1330
Query: 131 SVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKT----ETITYEEK 186
S + L+ + + + + + K +L+ SE +Q +T + I E+
Sbjct: 1331 SALAHALQSSRHDCDLLREQYEEEQEAKA-ELQRAMSKANSEVAQWRTKYETDAIQRTEE 1389
Query: 187 EQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVE 246
++ + L+DA + +++ + A + R Q E+ L+ +D+++ ACA
Sbjct: 1390 LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLM---IDVERTNAACAAL 1446
Query: 247 N-----------------EELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEEL 289
+ EE L A++ R L+ EL ++++ Y E ++ L + E
Sbjct: 1447 DKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKREN 1506
Query: 290 KNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQ--LEEAESPDITHQKRVFET 347
KNL+ + T + ++ + ++E + ELQ LEEAE+ + ++
Sbjct: 1507 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVE-QEKSELQAALEEAEASLEHEEGKILRI 1565
Query: 348 VRNINQV 354
+NQV
Sbjct: 1566 QLELNQV 1572
Score = 50.4 bits (119), Expect = 5e-06
Identities = 60/258 (23%), Positives = 115/258 (44%), Gaps = 28/258 (10%)
Query: 32 QDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNEL 91
+DL E++ ER + + +I+ + LE+ ER ++A + ++ + L +N
Sbjct: 1669 EDLKEQLAMVERRANLLQA--EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1726
Query: 92 LEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFH 151
L + + ++SQ++ E+ ++++Q +A EE +++ + E H
Sbjct: 1727 LINTKKKLETDISQIQGEM---EDIIQEARNA-EEKAKKAITDAAMMAEELKKEQDTSAH 1782
Query: 152 LDSLQKKL----KDL-----EEENVVLRSEASQL-KTETITYE-----EKEQQLVNDCVK 196
L+ ++K L KDL E E + L+ Q+ K E E E EQ+ + VK
Sbjct: 1783 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVK 1842
Query: 197 ELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGA 256
LR ++ +EL +TE+ ++ I L + LQ K K+ + EE +
Sbjct: 1843 GLRKHERKV----KELTYQTEE---DRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNV 1895
Query: 257 AKDAQRQLTAELRELEDK 274
R++ EL E E++
Sbjct: 1896 NLSKFRRIQHELEEAEER 1913
Score = 49.7 bits (117), Expect = 9e-06
Identities = 71/340 (20%), Positives = 133/340 (39%), Gaps = 46/340 (13%)
Query: 20 EERKPTHRQHDTQDLLEEVLCAE-RVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSL 78
+E+K H Q L+++ E +V +TK ++ + +++ E LE +I L
Sbjct: 998 KEKKALQEAH--QQTLDDLQAEEDKVNTLTKAKIKLE---QQVDDLEGSLEQEKKIRMDL 1052
Query: 79 LKKNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLK 138
+ + L +L +E I + QL +L K+ + S E+
Sbjct: 1053 ERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIED------------ 1100
Query: 139 RNESSSSVQNYFHLDSLQKKLKDLEEENVVLRS------------------------EAS 174
E + +Q + LQ ++++LEEE R+ EA
Sbjct: 1101 --EQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1158
Query: 175 QLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDA-ARQQEEITHLLSQI 233
+ I +K + ++L +A +Q + + L KK D+ A E+I +L
Sbjct: 1159 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1218
Query: 234 VDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLR 293
L+K+ +E ++L ++ A+ L R LED+ +E E Q + +L
Sbjct: 1219 QKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLT 1278
Query: 294 NKTMPNTTSRRYHSLGLFPMDSLAAEI-EGTMRKELQLEE 332
+ T +S L D+L +++ G Q+EE
Sbjct: 1279 AQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEE 1318
Score = 48.1 bits (113), Expect = 3e-05
Identities = 56/252 (22%), Positives = 103/252 (40%), Gaps = 29/252 (11%)
Query: 36 EEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQ 95
EE + AE + K ++ + + +++ E L + + K K LTE L+E
Sbjct: 933 EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDET 992
Query: 96 VEHIREEVSQLR--HELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLD 153
+ + +E L+ H+ ++ D LQ AEE + ++ +K + ++ L+
Sbjct: 993 IAKLTKEKKALQEAHQQTLDD--LQ-----AEEDKVNTLTKAKIKLEQQVDDLEG--SLE 1043
Query: 154 SLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELA 213
+K DLE L + + T+ E +QQL E+L
Sbjct: 1044 QEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQL------------------DEKLK 1085
Query: 214 KKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELED 273
KK + + Q +I + + LQKK K EEL + + A + ++ + + +L
Sbjct: 1086 KKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1145
Query: 274 KYAECMEMLHEA 285
+ E E L EA
Sbjct: 1146 ELEEISERLEEA 1157
Score = 46.6 bits (109), Expect = 8e-05
Identities = 58/308 (18%), Positives = 119/308 (38%), Gaps = 29/308 (9%)
Query: 14 EYDCQDEERKPTHRQHDTQDLLEEVLCAERVG-QMTKTYNDIDAVTRLLEEKERDLELAA 72
E D Q + K ++ + L ++ + +G Q+ K ++ A +EE E ++E
Sbjct: 1074 ENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQA---RIEELEEEIEAER 1130
Query: 73 RIGQSLLKKNKTLTERNELLEEQVEHIREEVS-QLRHELSMKDELLQFYTSAAEESEPES 131
K+ L+ E + E++E S Q+ + E + E +
Sbjct: 1131 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1190
Query: 132 VCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSE----ASQLKT--------- 178
+ L++ + S + +D+LQ+ + LE+E ++ E AS ++T
Sbjct: 1191 ATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLE 1250
Query: 179 -----------ETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEIT 227
E T EE++Q+L+ND + + S +L +K ++
Sbjct: 1251 KMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQ 1310
Query: 228 HLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQE 287
QI +L+++ + L L +++ L + E ++ AE + +A
Sbjct: 1311 AFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANS 1370
Query: 288 ELKNLRNK 295
E+ R K
Sbjct: 1371 EVAQWRTK 1378
Score = 44.3 bits (103), Expect = 4e-04
Identities = 56/307 (18%), Positives = 125/307 (40%), Gaps = 43/307 (14%)
Query: 21 ERKPTHRQHDTQDLLEEVL-CAERVGQMTKTYNDIDA----VTRLLEEKERDLE------ 69
+R+ + Q + DL E++ +R+ ++ K ++ + LEE E LE
Sbjct: 1503 KRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKI 1562
Query: 70 --LAARIGQSLLKKNKTLTERNELLEEQVEH---------------IREEVSQLRHELSM 112
+ + Q + ++ + E++E +++ + IR +R + M
Sbjct: 1563 LRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKM 1622
Query: 113 KDEL--LQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLR 170
+ +L ++ + A E++ + RN + HLD + +DL+E+ ++
Sbjct: 1623 EGDLNEMEIQLNHANRMAAEALRNY---RNTQAILKDTQLHLDDALRSQEDLKEQLAMVE 1679
Query: 171 SEASQLKTE----TITYEEKE------QQLVNDCVKELRDANVQIASISEELAKKTEDAA 220
A+ L+ E T E+ E +Q + D + ++ + Q S+ K D +
Sbjct: 1680 RRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDIS 1739
Query: 221 RQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECME 280
+ Q E+ ++ + + ++KAK + + + L +D L + LE +
Sbjct: 1740 QIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1799
Query: 281 MLHEAQE 287
L EA++
Sbjct: 1800 RLDEAEQ 1806
Score = 40.0 bits (92), Expect = 0.007
Identities = 97/483 (20%), Positives = 180/483 (37%), Gaps = 76/483 (15%)
Query: 15 YDCQDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARI 74
+DC + Q +L + A +T + DA+ R E +E +LA R+
Sbjct: 1342 HDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1401
Query: 75 G------QSLLKKNKTLTERNELLEEQVEHIREEVSQ-------LRHELSMKDELLQFYT 121
+++ K +L + + L+ +VE + +V + L + D++L +
Sbjct: 1402 QDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWK 1461
Query: 122 SAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETI 181
EE+ E S R+ S+ + + +L+ L+ EN L+ E S L TE I
Sbjct: 1462 QKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDL-TEQI 1520
Query: 182 TYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAK 241
K + K++ ++ + EE +A+ + EE L Q+ Q K++
Sbjct: 1521 AEGGKRIHELEKIKKQVEQEKSELQAALEEA-----EASLEHEEGKILRIQLELNQVKSE 1575
Query: 242 A---CAVENEELVQ----HLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQE-ELKNLR 293
A ++EE+ Q H+ + Q L AE+R D +M + E E++
Sbjct: 1576 VDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNH 1635
Query: 294 NKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEA--ESPDITHQKRVFETVRNI 351
M R Y + D+ +L L++A D+ Q + E N+
Sbjct: 1636 ANRMAAEALRNYRNTQAILKDT-----------QLHLDDALRSQEDLKEQLAMVERRANL 1684
Query: 352 NQVVKQRSLTPSPMNIPGSNQSSAMNSLLSSCVSTPRSSFYGSDIGNVVLDNKTNSIILE 411
Q + + L ++ T RS +LD +L
Sbjct: 1685 LQ--------------------AEIEELRATLEQTERSRKIAEQ---ELLDASERVQLLH 1721
Query: 412 TEAADLGNDERSKKPGTPGTPGSHDLETALRRLSLRRENYLSERRFFEEEQERKLQELAE 471
T+ L N ++ LET + ++ E+ + E R EE+ ++ + + A
Sbjct: 1722 TQNTSLINTKKK-------------LETDISQIQGEMEDIIQEARNAEEKAKKAITDAAM 1768
Query: 472 KGE 474
E
Sbjct: 1769 MAE 1771
Score = 38.9 bits (89), Expect = 0.016
Identities = 34/147 (23%), Positives = 67/147 (45%), Gaps = 4/147 (2%)
Query: 149 YFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCV---KELRDANVQI 205
YF + L K + E+E ++ E + K E E K ++L V +E D +Q+
Sbjct: 837 YFKIKPLLKSA-ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQV 895
Query: 206 ASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLT 265
+ ++ LA E + + L ++I ++ ++A+ N EL +D +L
Sbjct: 896 QAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 955
Query: 266 AELRELEDKYAECMEMLHEAQEELKNL 292
++ +LE A+ + H + ++KNL
Sbjct: 956 KDIDDLELTLAKVEKEKHATENKVKNL 982
Score = 37.4 bits (85), Expect = 0.047
Identities = 57/303 (18%), Positives = 118/303 (38%), Gaps = 44/303 (14%)
Query: 43 RVGQMTKTYNDIDAVTRLLEEKERDLELAARIG---QSLLKKNKTLTERNELLEEQVE-- 97
++ + K+ + + EE E+ E A+ + L +K TL + L+ QV+
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAE 898
Query: 98 -----HIREEVSQLRHELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHL 152
E QL + ++ T AE+ E +
Sbjct: 899 ADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINA-------------------- 938
Query: 153 DSLQKKLKDLEEENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEEL 212
L K + LE+E L+ + L+ T+ EKE+ + VK L + ++A + E +
Sbjct: 939 -ELTAKKRKLEDECSELKKDIDDLEL-TLAKVEKEKHATENKVKNLTE---EMAGLDETI 993
Query: 213 AKKTEDAARQQEEITHLLSQIVDLQKKAKA---CAVENEELVQHLGAAKDAQRQLTAELR 269
AK T++ QE L + + K ++ E+ V L + + ++++ +L
Sbjct: 994 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLE 1053
Query: 270 ELEDKYAECMEMLHEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQ 329
+ K +++ E+ +++N + + + F M L ++IE +Q
Sbjct: 1054 RAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE------FEMSGLQSKIEDEQALGMQ 1107
Query: 330 LEE 332
L++
Sbjct: 1108 LQK 1110
>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
sapiens]
Length = 693
Score = 59.3 bits (142), Expect = 1e-08
Identities = 76/324 (23%), Positives = 138/324 (42%), Gaps = 57/324 (17%)
Query: 60 LLEEKERDLELAARIGQSLLK-KNK----------TLTERNELLEEQVEHIREEVSQLRH 108
L EEK+RD+ + +SL + KN+ +T E L+++ +H+R+EV L
Sbjct: 257 LKEEKKRDIHRIQELERSLSELKNQMAKPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEG 316
Query: 109 ELSMKDELLQFYTSAAEESEPESVCSTPLKRNESSSSVQNYFHL----DSLQKKLKDLEE 164
+L + E Q + ++E + + R + V+ L + L+++ K L+E
Sbjct: 317 KLQSQVENNQALSLLSKEQKQRLQEQEEMLREQEVQRVREQERLCEQNERLREQQKTLQE 376
Query: 165 ENVVLRSEASQLKTETITYEEKEQQLVNDCVKELRDANVQIASISEELAKKTEDAARQQE 224
+ LR + +L+ + ++E++L K L D E L KK E +Q+E
Sbjct: 377 QGERLRKQEQRLRKQEERLRKEEERLQKQ-EKRLWDQ-------EERLWKKEERLQKQEE 428
Query: 225 EITHLLSQIVDLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHE 284
+ + +D Q C+ E+ L K + QL +++EL++K E E L
Sbjct: 429 RLALSQNHKLDKQLAEPQCSFED------LNNEKKSALQLEQQVKELQEKLDE--EHLEA 480
Query: 285 AQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQLEEAESPDITHQKRV 344
A ++ + L + + +A EG + L EE E+P T
Sbjct: 481 ASQQNQQLETQ-----------------LSLVALPGEGDGGQHLDSEEEEAPRPT----- 518
Query: 345 FETVRNINQVVKQRSLTPSPMNIP 368
NI + ++ R T S M++P
Sbjct: 519 ----PNIPEDLESREATSSFMDLP 538
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 58.5 bits (140), Expect = 2e-08
Identities = 80/383 (20%), Positives = 158/383 (41%), Gaps = 45/383 (11%)
Query: 37 EVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQV 96
EVL A + + TK ++ + + EEK DL+ + + K L ++ E E+Q+
Sbjct: 700 EVLQA-KCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI 758
Query: 97 EHIREE-------VSQLRHELSMKD-ELLQFYTSAAEESEPESVCSTPL--------KRN 140
+H+ E S + EL ++ +L + +E S+ + L + +
Sbjct: 759 KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 818
Query: 141 ESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYE-------EKEQQLV-- 191
E + SVQ + KL EE+ +L S+ +L+ E E+E+QL+
Sbjct: 819 EEAVSVQR--SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 876
Query: 192 -----NDCVKELR---DANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKAC 243
ND + ++ D + Q+ +++EL K D Q ++T LQK +
Sbjct: 877 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 936
Query: 244 AVENEELVQ-----HLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMP 298
V+ E+ Q H K+ +R+L+ +++E + +C E+ +A+ E KT
Sbjct: 937 TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL--KARYERATSETKTKH 994
Query: 299 NTTSRRYHSLGLFPMDSL--AAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVK 356
+ L D L A E + +EL+ ++ + + ++ + Q+ K
Sbjct: 995 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTK 1054
Query: 357 QRSLTPSPMNIPGSNQSSAMNSL 379
+++ T + + + N L
Sbjct: 1055 EKTETLASLEDTKQTNAKLQNEL 1077
Score = 50.1 bits (118), Expect = 7e-06
Identities = 61/283 (21%), Positives = 125/283 (44%), Gaps = 33/283 (11%)
Query: 62 EEKERDLELAARIGQSLLK---KNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQ 118
E K + E+ + ++LL K K E N L +++E +R++ + + + +D +
Sbjct: 989 ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQI 1048
Query: 119 FYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKT 178
E++E + + N LQ +L L+E N+ E ++ K
Sbjct: 1049 MEQMTKEKTETLASLEDTKQTNAK------------LQNELDTLKENNLKNVEELNKSK- 1095
Query: 179 ETITYEEKEQQLVNDCVKELRDA----NVQIASISEELAKKTEDAARQQEEITHLLSQIV 234
E +T E ++ + ++ L+ A + Q++++ EE K E+ R ++E+T
Sbjct: 1096 ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVT------- 1148
Query: 235 DLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRN 294
QK + +V N +L++ + E L+ + +L E EL+ LRN
Sbjct: 1149 SHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRN 1208
Query: 295 KTM----PNTTSRRYHSLGLFPMDSLAAEIEGTMRK-ELQLEE 332
+ N +++ HS+ + ++S ++E ++ ELQL+E
Sbjct: 1209 EVTVLRGENASAKSLHSV-VQTLESDKVKLELKVKNLELQLKE 1250
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/388 (20%), Positives = 161/388 (41%), Gaps = 68/388 (17%)
Query: 20 EERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLL 79
E KP + LL+E+ + ++T+T + + +T L E E + ++L
Sbjct: 488 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQRE-ITSLKEHFGAREETHQKEIKALY 546
Query: 80 KKNKTLTERNELLEEQVEHIREEVSQL-------------RHELSMKDELLQFYTSAAEE 126
+ L++ NE L+ ++EH +E S + H+ +M++ + F E
Sbjct: 547 TATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTE 606
Query: 127 SEPESVCSTP--------------LKRNESSSSVQNYFHLDSLQKKL-KDLEEENVVLRS 171
+ + T L+ + S + +++L+ KL K ++E+ L +
Sbjct: 607 TAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEA 666
Query: 172 EASQLKTETITYEEKEQQLV--NDCVKELRDANVQIASISEELAKKTEDAARQQEEITHL 229
S+L + ++Q LV D + +L++A +++ + E L K + + + T
Sbjct: 667 IRSKLD------KAEDQHLVEMEDTLNKLQEAEIKVKEL-EVLQAKCNEQTKVIDNFTSQ 719
Query: 230 L----SQIVDLQKKAKACA---VENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEML 282
L +++DL KA + E ++L Q L AA+ + L E K + L
Sbjct: 720 LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITREL 779
Query: 283 HEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQL-----EEAESPD 337
+ +L NL+ S ++++ T+ KELQ+ EA
Sbjct: 780 QGRELKLTNLQENL------------------SEVSQVKETLEKELQILKEKFAEASEEA 821
Query: 338 ITHQKRVFETVRNINQVVKQRSLTPSPM 365
++ Q+ + ETV ++Q +Q ++ S +
Sbjct: 822 VSVQRSMQETVNKLHQKEEQFNMLSSDL 849
Score = 45.4 bits (106), Expect = 2e-04
Identities = 54/233 (23%), Positives = 108/233 (46%), Gaps = 17/233 (7%)
Query: 18 QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQS 77
+D ++ Q++ L E L + V ++ K+ + + +EE +++E +
Sbjct: 1064 EDTKQTNAKLQNELDTLKENNL--KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQ 1121
Query: 78 LLKKNKTLTERNELLEEQVEHIREEVS---QLRHELS-MKDELLQFYTSAAEESEPESVC 133
++ L E N L E++ R+EV+ +L E S + ++LL+ ++ +
Sbjct: 1122 KSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEE 1181
Query: 134 STPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKT-----ETITYEEKEQ 188
L+++ S +S L +L+ L E VLR E + K+ +T+ ++ +
Sbjct: 1182 KASLQKSISITSAL----LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKL 1237
Query: 189 QL-VNDCVKELRDANVQIASISEEL-AKKTEDAARQQEEITHLLSQIVDLQKK 239
+L V + +L++ Q++S S + ED Q+ +I L S IVDLQ+K
Sbjct: 1238 ELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRK 1290
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 58.5 bits (140), Expect = 2e-08
Identities = 80/383 (20%), Positives = 158/383 (41%), Gaps = 45/383 (11%)
Query: 37 EVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLLKKNKTLTERNELLEEQV 96
EVL A + + TK ++ + + EEK DL+ + + K L ++ E E+Q+
Sbjct: 735 EVLQA-KCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI 793
Query: 97 EHIREE-------VSQLRHELSMKD-ELLQFYTSAAEESEPESVCSTPL--------KRN 140
+H+ E S + EL ++ +L + +E S+ + L + +
Sbjct: 794 KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 853
Query: 141 ESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKTETITYE-------EKEQQLV-- 191
E + SVQ + KL EE+ +L S+ +L+ E E+E+QL+
Sbjct: 854 EEAVSVQR--SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 911
Query: 192 -----NDCVKELR---DANVQIASISEELAKKTEDAARQQEEITHLLSQIVDLQKKAKAC 243
ND + ++ D + Q+ +++EL K D Q ++T LQK +
Sbjct: 912 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 971
Query: 244 AVENEELVQ-----HLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRNKTMP 298
V+ E+ Q H K+ +R+L+ +++E + +C E+ +A+ E KT
Sbjct: 972 TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL--KARYERATSETKTKH 1029
Query: 299 NTTSRRYHSLGLFPMDSL--AAEIEGTMRKELQLEEAESPDITHQKRVFETVRNINQVVK 356
+ L D L A E + +EL+ ++ + + ++ + Q+ K
Sbjct: 1030 EEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTK 1089
Query: 357 QRSLTPSPMNIPGSNQSSAMNSL 379
+++ T + + + N L
Sbjct: 1090 EKTETLASLEDTKQTNAKLQNEL 1112
Score = 50.1 bits (118), Expect = 7e-06
Identities = 61/283 (21%), Positives = 125/283 (44%), Gaps = 33/283 (11%)
Query: 62 EEKERDLELAARIGQSLLK---KNKTLTERNELLEEQVEHIREEVSQLRHELSMKDELLQ 118
E K + E+ + ++LL K K E N L +++E +R++ + + + +D +
Sbjct: 1024 ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQI 1083
Query: 119 FYTSAAEESEPESVCSTPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKT 178
E++E + + N LQ +L L+E N+ E ++ K
Sbjct: 1084 MEQMTKEKTETLASLEDTKQTNAK------------LQNELDTLKENNLKNVEELNKSK- 1130
Query: 179 ETITYEEKEQQLVNDCVKELRDA----NVQIASISEELAKKTEDAARQQEEITHLLSQIV 234
E +T E ++ + ++ L+ A + Q++++ EE K E+ R ++E+T
Sbjct: 1131 ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVT------- 1183
Query: 235 DLQKKAKACAVENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEMLHEAQEELKNLRN 294
QK + +V N +L++ + E L+ + +L E EL+ LRN
Sbjct: 1184 SHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRN 1243
Query: 295 KTM----PNTTSRRYHSLGLFPMDSLAAEIEGTMRK-ELQLEE 332
+ N +++ HS+ + ++S ++E ++ ELQL+E
Sbjct: 1244 EVTVLRGENASAKSLHSV-VQTLESDKVKLELKVKNLELQLKE 1285
Score = 49.3 bits (116), Expect = 1e-05
Identities = 79/388 (20%), Positives = 161/388 (41%), Gaps = 68/388 (17%)
Query: 20 EERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQSLL 79
E KP + LL+E+ + ++T+T + + +T L E E + ++L
Sbjct: 523 ESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQRE-ITSLKEHFGAREETHQKEIKALY 581
Query: 80 KKNKTLTERNELLEEQVEHIREEVSQL-------------RHELSMKDELLQFYTSAAEE 126
+ L++ NE L+ ++EH +E S + H+ +M++ + F E
Sbjct: 582 TATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTE 641
Query: 127 SEPESVCSTP--------------LKRNESSSSVQNYFHLDSLQKKL-KDLEEENVVLRS 171
+ + T L+ + S + +++L+ KL K ++E+ L +
Sbjct: 642 TAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEA 701
Query: 172 EASQLKTETITYEEKEQQLV--NDCVKELRDANVQIASISEELAKKTEDAARQQEEITHL 229
S+L + ++Q LV D + +L++A +++ + E L K + + + T
Sbjct: 702 IRSKLD------KAEDQHLVEMEDTLNKLQEAEIKVKEL-EVLQAKCNEQTKVIDNFTSQ 754
Query: 230 L----SQIVDLQKKAKACA---VENEELVQHLGAAKDAQRQLTAELRELEDKYAECMEML 282
L +++DL KA + E ++L Q L AA+ + L E K + L
Sbjct: 755 LKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITREL 814
Query: 283 HEAQEELKNLRNKTMPNTTSRRYHSLGLFPMDSLAAEIEGTMRKELQL-----EEAESPD 337
+ +L NL+ S ++++ T+ KELQ+ EA
Sbjct: 815 QGRELKLTNLQENL------------------SEVSQVKETLEKELQILKEKFAEASEEA 856
Query: 338 ITHQKRVFETVRNINQVVKQRSLTPSPM 365
++ Q+ + ETV ++Q +Q ++ S +
Sbjct: 857 VSVQRSMQETVNKLHQKEEQFNMLSSDL 884
Score = 45.4 bits (106), Expect = 2e-04
Identities = 54/233 (23%), Positives = 108/233 (46%), Gaps = 17/233 (7%)
Query: 18 QDEERKPTHRQHDTQDLLEEVLCAERVGQMTKTYNDIDAVTRLLEEKERDLELAARIGQS 77
+D ++ Q++ L E L + V ++ K+ + + +EE +++E +
Sbjct: 1099 EDTKQTNAKLQNELDTLKENNL--KNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQ 1156
Query: 78 LLKKNKTLTERNELLEEQVEHIREEVS---QLRHELS-MKDELLQFYTSAAEESEPESVC 133
++ L E N L E++ R+EV+ +L E S + ++LL+ ++ +
Sbjct: 1157 KSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEE 1216
Query: 134 STPLKRNESSSSVQNYFHLDSLQKKLKDLEEENVVLRSEASQLKT-----ETITYEEKEQ 188
L+++ S +S L +L+ L E VLR E + K+ +T+ ++ +
Sbjct: 1217 KASLQKSISITSAL----LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKL 1272
Query: 189 QL-VNDCVKELRDANVQIASISEEL-AKKTEDAARQQEEITHLLSQIVDLQKK 239
+L V + +L++ Q++S S + ED Q+ +I L S IVDLQ+K
Sbjct: 1273 ELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRK 1325
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.126 0.344
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,260,949
Number of Sequences: 37866
Number of extensions: 1361087
Number of successful extensions: 19593
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 344
Number of HSP's successfully gapped in prelim test: 975
Number of HSP's that attempted gapping in prelim test: 12364
Number of HSP's gapped (non-prelim): 5448
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.