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Search of human proteins with 45237195
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45237195 Janus kinase and microtubule interacting protein 2
[Homo sapiens]
(810 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45237195 Janus kinase and microtubule interacting protein 2 [... 1561 0.0
gi|150456473 janus kinase and microtubule interacting protein 1 ... 1016 0.0
gi|157502225 Janus kinase and microtubule interacting protein 3 ... 939 0.0
gi|21389505 janus kinase and microtubule interacting protein 1 i... 729 0.0
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 107 4e-23
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 107 4e-23
gi|21735548 centrosomal protein 2 [Homo sapiens] 104 4e-22
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 101 2e-21
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 101 2e-21
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 100 5e-21
gi|148746195 trichohyalin [Homo sapiens] 100 7e-21
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 100 9e-21
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 99 2e-20
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 99 2e-20
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 99 2e-20
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 99 2e-20
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 99 2e-20
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 98 4e-20
gi|71061468 centromere protein E [Homo sapiens] 97 8e-20
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 95 2e-19
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 94 7e-19
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 92 2e-18
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 92 2e-18
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 92 2e-18
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 92 2e-18
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 92 2e-18
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 92 2e-18
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 92 2e-18
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 92 2e-18
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 92 3e-18
>gi|45237195 Janus kinase and microtubule interacting protein 2
[Homo sapiens]
Length = 810
Score = 1561 bits (4043), Expect = 0.0
Identities = 810/810 (100%), Positives = 810/810 (100%)
Query: 1 MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRE 60
MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRE
Sbjct: 1 MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRE 60
Query: 61 LEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCA 120
LEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCA
Sbjct: 61 LEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCA 120
Query: 121 LRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIK 180
LRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIK
Sbjct: 121 LRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIK 180
Query: 181 AGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ 240
AGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ
Sbjct: 181 AGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ 240
Query: 241 KEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLED 300
KEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLED
Sbjct: 241 KEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLED 300
Query: 301 RNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSE 360
RNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSE
Sbjct: 301 RNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSE 360
Query: 361 MREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHR 420
MREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHR
Sbjct: 361 MREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHR 420
Query: 421 RSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQ 480
RSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQ
Sbjct: 421 RSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQ 480
Query: 481 LTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDS 540
LTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDS
Sbjct: 481 LTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDS 540
Query: 541 HWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPP 600
HWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPP
Sbjct: 541 HWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPP 600
Query: 601 FNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVL 660
FNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVL
Sbjct: 601 FNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVL 660
Query: 661 SLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELE 720
SLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELE
Sbjct: 661 SLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELE 720
Query: 721 ATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQA 780
ATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQA
Sbjct: 721 ATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQA 780
Query: 781 HQRIRDLEDKTDIQKRQIKDLEEKSNRKHG 810
HQRIRDLEDKTDIQKRQIKDLEEKSNRKHG
Sbjct: 781 HQRIRDLEDKTDIQKRQIKDLEEKSNRKHG 810
>gi|150456473 janus kinase and microtubule interacting protein 1
isoform 1 [Homo sapiens]
Length = 831
Score = 1016 bits (2626), Expect = 0.0
Identities = 532/816 (65%), Positives = 662/816 (81%), Gaps = 13/816 (1%)
Query: 1 MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRE 60
MSKKGR+KGEKPE A+Q ANE+LR KLT IQIE QEKSKV KL RE+ QEAK RE
Sbjct: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKL-RERLQEAKLERE 59
Query: 61 LEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCA 120
EQR+HT ++ELKAKLHEEK KELQA+RE LI+QHEQE +RT K+++GE+QRL++ L
Sbjct: 60 QEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNV 119
Query: 121 LRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIK 180
LRDG++DKV+TAL EAREEAR+ FD ERL+L QEI +LK A+KQ +EALSN +QADK K
Sbjct: 120 LRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTK 179
Query: 181 AGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ 240
A DLR+ +Q+HQ+ + +IK E ERDIRRLMDEIK KDR+I +LEKEL Q G QKL LQ
Sbjct: 180 AADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQ 239
Query: 241 KEALDEQLFLVKEAECNMSSPKREIPGRAGD-------GSEHCSSPDLRRNQKRIAELNA 293
KEALDEQL VKEAE + SSPKRE+P GD +H D+RR Q +IAELN+
Sbjct: 240 KEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNS 299
Query: 294 TIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKA 353
IRKLEDRNTLL DERNELLKR RETE Q KPL+E+NK + K+N++L+ S+QRMEEK+K
Sbjct: 300 VIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKN 359
Query: 354 VTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKL 413
+T+EN EM+EK+++ LK+ SLNDL +EQE EFL+LQV+EQQ++ID+L+ +RE+L
Sbjct: 360 LTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERL 419
Query: 414 IRRRKHR-RSSKPIKRPVLDPFIGYDEDSMDSETSSMASF---RTDRTPATPDDDLDESL 469
+R ++HR +S KP K+ V++ F G+DE+S+DSET S S+ RTDRTPATP++DLD++
Sbjct: 420 LRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT 479
Query: 470 AAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDL 529
A EE++LRF QLT+EYQALQRAYALLQEQ GG +DAEREA+ +EQLQA++LR +AKIEDL
Sbjct: 480 AREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDL 539
Query: 530 EATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNL 589
E L +KGQDS WVE+KQL I+ NQ+LLEKI + E E ++L+ E+QDA+DQNELLEFR L
Sbjct: 540 EKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVL 599
Query: 590 ELEERERRSPPFNLQIHPFSDG-VSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNE 648
ELEERERRSP FNLQI F + SALQ++C +EGVKDVN+ +L+K+LDILGDNGNLRNE
Sbjct: 600 ELEERERRSPAFNLQITTFPENHSSALQLFCHQEGVKDVNVSELMKKLDILGDNGNLRNE 659
Query: 649 EQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQA 708
EQVAIIQA TVL+L EKW++QIEG EAAL QKM++LE + + F + KGYLEEELDYRKQA
Sbjct: 660 EQVAIIQAGTVLALCEKWLKQIEGTEAALTQKMLDLEKEKDLFSRQKGYLEEELDYRKQA 719
Query: 709 LDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQ 768
LDQAY++IQ+LEATLY ALQQE + GE LSE Q+E+L+ AVEK+RRQ+LR+SRE+D Q
Sbjct: 720 LDQAYLKIQDLEATLYTALQQEPGRRAGEALSEGQREDLQAAVEKVRRQILRQSREFDSQ 779
Query: 769 ILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEK 804
IL+ERMELLQQA QRIR+LEDK + QKR +K+LEEK
Sbjct: 780 ILRERMELLQQAQQRIRELEDKLEFQKRHLKELEEK 815
>gi|157502225 Janus kinase and microtubule interacting protein 3
[Homo sapiens]
Length = 844
Score = 939 bits (2426), Expect = 0.0
Identities = 505/832 (60%), Positives = 645/832 (77%), Gaps = 32/832 (3%)
Query: 1 MSKKG---RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKR 57
MSK+G R KG+K EAL ALQAANEDLR KLTDIQIEL QEKSKVSK+EREK QE ++
Sbjct: 1 MSKRGMSSRAKGDKAEAL-AALQAANEDLRAKLTDIQIELQQEKSKVSKVEREKNQELRQ 59
Query: 58 IRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSA 117
+RE EQ K VL+TELK KLHEEKMKELQAVRE L++QHE E+ R +K++D E QRL++
Sbjct: 60 VREHEQHKTAVLLTELKTKLHEEKMKELQAVRETLLRQHEAELLRVIKIKDNENQRLQAL 119
Query: 118 LCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQAD 177
L ALRDG +KV+T L EA+EEA+K F+ E++K+ QEI++LK AK+QV+EAL+ +IQAD
Sbjct: 120 LSALRDGGPEKVKTVLLSEAKEEAKKGFEVEKVKMQQEISELKGAKRQVEEALTLVIQAD 179
Query: 178 KIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKL 237
KIKA ++RS + HQE I++IK E ER+IRRLM+EIK KDR +F LE+EL Q G+ Q+L
Sbjct: 180 KIKAAEIRSVYHLHQEEITRIKKECEREIRRLMEEIKFKDRAVFVLERELGVQAGHAQRL 239
Query: 238 QLQKEALDEQLFLVKEAECNMSSPKREIP--GRAGDGSEHCSSP-------DLRRNQKRI 288
QLQKEALDEQL V+EA+ + SP+RE+P AGD S+H SP D RR Q +I
Sbjct: 240 QLQKEALDEQLSQVREADRHPGSPRRELPHAAGAGDASDHSGSPEQQLDEKDARRFQLKI 299
Query: 289 AELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRME 348
AEL+A IRKLEDRN LL +ERNELLKRVRE E Q KPLL++NK L+++N++L +L+RME
Sbjct: 300 AELSAIIRKLEDRNALLSEERNELLKRVREAESQYKPLLDKNKRLSRKNEDLSHALRRME 359
Query: 349 EKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTR 408
KLK VT+EN EMR++ +++ SLNDLDQ+ +E+E +FLKLQ++EQQN+IDEL++
Sbjct: 360 NKLKFVTQENIEMRQRAGI---IRRPSSLNDLDQSQDEREVDFLKLQIVEQQNLIDELSK 416
Query: 409 ------------DREKLIRRRKHRRSSKPIKRPVL-DPFIGYDED-SMDSETSSMA--SF 452
+R+KL+R RK R+ + +PV+ + F GYDE+ S++S+ SS++ +
Sbjct: 417 TLETAGYVKSVLERDKLLRFRKQRKKMAKLPKPVVVETFFGYDEEASLESDGSSVSYQTD 476
Query: 453 RTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQ 512
RTD+TP TPDDDL+E +A EE+ELRFRQLT EYQALQRAYALLQEQ GG +DAERE K +
Sbjct: 477 RTDQTPCTPDDDLEEGMAKEETELRFRQLTMEYQALQRAYALLQEQVGGTLDAEREVKTR 536
Query: 513 EQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQ 572
EQLQAEV R +A+IEDLE LA++GQD W+E+KQ +RNQEL+EKI++ E E RL+
Sbjct: 537 EQLQAEVQRAQARIEDLEKALAEQGQDMKWIEEKQALYRRNQELVEKIKQMETEEARLRH 596
Query: 573 ELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDL 632
E+QDARDQNELLEFR LELEERER+SP + PF DG S LQ+YC EGV D+ + +L
Sbjct: 597 EVQDARDQNELLEFRILELEERERKSPAISFHHTPFVDGKSPLQVYCEAEGVTDIVVAEL 656
Query: 633 IKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFC 692
+K+LDILGDN NL NEEQV +IQA TVL+LAEKW+QQIE EAAL +KM++LES+ E F
Sbjct: 657 MKKLDILGDNANLTNEEQVVVIQARTVLTLAEKWLQQIEETEAALQRKMVDLESEKELFS 716
Query: 693 KIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVE 752
K KGYL+EELDYRKQALDQA I ELEA LY+ALQQE K ELLSE+++E+L+ AVE
Sbjct: 717 KQKGYLDEELDYRKQALDQANKHILELEAMLYDALQQEAGAKVAELLSEEEREKLKVAVE 776
Query: 753 KLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEK 804
+ +RQ++ + RE D QIL+ERMELLQ A QRI++LE++ + QKRQIK+LEEK
Sbjct: 777 QWKRQVMSELRERDAQILRERMELLQLAQQRIKELEERIEAQKRQIKELEEK 828
>gi|21389505 janus kinase and microtubule interacting protein 1
isoform 2 [Homo sapiens]
Length = 626
Score = 729 bits (1881), Expect = 0.0
Identities = 383/606 (63%), Positives = 482/606 (79%), Gaps = 12/606 (1%)
Query: 1 MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRE 60
MSKKGR+KGEKPE A+Q ANE+LR KLT IQIE QEKSKV KL RE+ QEAK RE
Sbjct: 1 MSKKGRSKGEKPEMETDAVQMANEELRAKLTSIQIEFQQEKSKVGKL-RERLQEAKLERE 59
Query: 61 LEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCA 120
EQR+HT ++ELKAKLHEEK KELQA+RE LI+QHEQE +RT K+++GE+QRL++ L
Sbjct: 60 QEQRRHTAYISELKAKLHEEKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNV 119
Query: 121 LRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIK 180
LRDG++DKV+TAL EAREEAR+ FD ERL+L QEI +LK A+KQ +EALSN +QADK K
Sbjct: 120 LRDGAADKVKTALLTEAREEARRAFDGERLRLQQEILELKAARKQAEEALSNCMQADKTK 179
Query: 181 AGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ 240
A DLR+ +Q+HQ+ + +IK E ERDIRRLMDEIK KDR+I +LEKEL Q G QKL LQ
Sbjct: 180 AADLRAAYQAHQDEVHRIKRECERDIRRLMDEIKGKDRVILALEKELGVQAGQTQKLLLQ 239
Query: 241 KEALDEQLFLVKEAECNMSSPKREIPGRAGD-------GSEHCSSPDLRRNQKRIAELNA 293
KEALDEQL VKEAE + SSPKRE+P GD +H D+RR Q +IAELN+
Sbjct: 240 KEALDEQLVQVKEAERHHSSPKRELPPGIGDMVELMGVQDQHMDERDVRRFQLKIAELNS 299
Query: 294 TIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKA 353
IRKLEDRNTLL DERNELLKR RETE Q KPL+E+NK + K+N++L+ S+QRMEEK+K
Sbjct: 300 VIRKLEDRNTLLADERNELLKRSRETEVQLKPLVEKNKRMNKKNEDLLQSIQRMEEKIKN 359
Query: 354 VTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKL 413
+T+EN EM+EK+++ LK+ SLNDL +EQE EFL+LQV+EQQ++ID+L+ +RE+L
Sbjct: 360 LTRENVEMKEKLSAQASLKRHTSLNDLSLTRDEQEIEFLRLQVLEQQHVIDDLSLERERL 419
Query: 414 IRRRKHR-RSSKPIKRPVLDPFIGYDEDSMDSETSSMASF---RTDRTPATPDDDLDESL 469
+R ++HR +S KP K+ V++ F G+DE+S+DSET S S+ RTDRTPATP++DLD++
Sbjct: 420 LRSKRHRGKSLKPPKKHVVETFFGFDEESVDSETLSETSYNTDRTDRTPATPEEDLDDAT 479
Query: 470 AAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDL 529
A EE++LRF QLT+EYQALQRAYALLQEQ GG +DAEREA+ +EQLQA++LR +AKIEDL
Sbjct: 480 AREEADLRFCQLTREYQALQRAYALLQEQVGGTLDAEREARTREQLQADLLRCQAKIEDL 539
Query: 530 EATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNL 589
E L +KGQDS WVE+KQL I+ NQ+LLEKI + E E ++L+ E+QDA+DQNELLEFR L
Sbjct: 540 EKLLVEKGQDSKWVEEKQLLIRTNQDLLEKIYRLEMEENQLKNEMQDAKDQNELLEFRVL 599
Query: 590 ELEERE 595
ELE R+
Sbjct: 600 ELEVRD 605
Score = 31.2 bits (69), Expect = 4.0
Identities = 38/146 (26%), Positives = 63/146 (43%), Gaps = 8/146 (5%)
Query: 670 IEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMR----IQELEATLYN 725
++ A L K+ ++ + +Q G L E L K +Q R I EL+A L+
Sbjct: 19 VQMANEELRAKLTSIQIEFQQEKSKVGKLRERLQEAKLEREQEQRRHTAYISELKAKLHE 78
Query: 726 ALQQETVIKFGELLSEKQQEELRTAVEK---LRRQMLRKSREYDCQILQERMELLQQAHQ 782
+E L+ + +QE RTA K L+R + D + + LL +A +
Sbjct: 79 EKTKELQALREGLIRQHEQEAARTAKIKEGELQRLQATLNVLRDGAADKVKTALLTEARE 138
Query: 783 RIRDLEDKTDIQKRQIKDLEEKSNRK 808
R D ++ +Q + LE K+ RK
Sbjct: 139 EARRAFDGERLRLQQ-EILELKAARK 163
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 107 bits (267), Expect = 4e-23
Identities = 170/855 (19%), Positives = 376/855 (43%), Gaps = 79/855 (9%)
Query: 5 GRNKGEKPEALIVALQAANEDLRTKLTDIQI---ELHQEKSKVSKLEREKTQEAKRIREL 61
G E + ++ L+ N+ L + +++ + SK+ K+E+E + +K++ L
Sbjct: 451 GHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510
Query: 62 E----QRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSA 117
E Q K ++ + L ++ MKE +A E I+ + R +K+ + E + L
Sbjct: 511 ENEIVQEKQSLQNCQ---NLSKDLMKE-KAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 118 LCALRDGSSDKVRTALTIEAR----EEARKLFDTERLKLLQEIADLKTAKKQVDEALSNM 173
+ +LR R+ ++ EAR E+ K+ + +++ ++ K+Q+ + L +
Sbjct: 567 VSSLRQ------RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620
Query: 174 IQ----ADKI--KAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKEL 227
+ A+++ + L E++ Q+ I+ +K E+ I L E +R L+K L
Sbjct: 621 KEKGERAEELENELHHLEKENELLQKKITNLKITCEK-IEALEQENSELERENRKLKKTL 679
Query: 228 ET---QTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPD---- 280
++ T ++ L+ + LDE+ ++ ++ ++ + E S +
Sbjct: 680 DSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKK 739
Query: 281 ----LRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKR 336
L+ + K+ L + + L+ N L K++++ E + + L N+ L K
Sbjct: 740 GLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN 799
Query: 337 NDELMVS---LQRMEEKLKAVTKENSEM-REKITSHPPLKKLKSLNDLDQANEEQETEFL 392
+EL +S L+++E++ K++ +E S++ ++K K+L+ ++ E+ +
Sbjct: 800 LEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENN--V 857
Query: 393 KLQVIEQQN--IIDELTRDREKLIRRRKHRRSSKP-IKRPVLD--PFIGYDEDSMDSETS 447
K+ +E++N + E+ +E +R ++ + +K +KR +D + ED + SE
Sbjct: 858 KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED-LVSEKL 916
Query: 448 SMASFRTDRTPATPDDDL----DESLAAEE---SELRFRQLTKEYQALQRAYALLQEQTG 500
D T + + E L +E + R++ L + ++ + ++E+
Sbjct: 917 KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKI 976
Query: 501 GIIDA--EREAKAQEQLQAEVLRYKAKIEDL-----EATLAQ-----KGQDSHWVEDKQL 548
++A E +QL+ E+ K E L E + Q G+D+ W + Q
Sbjct: 977 AALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQE 1036
Query: 549 FIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEER----ERRSPPFNLQ 604
+ ++ +++ + E N LQ E Q + Q + LE +N L+ + +R++ Q
Sbjct: 1037 TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1096
Query: 605 IHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAE 664
+ LQ+ + ++ + QL L +L NE + I + + SL +
Sbjct: 1097 NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL--LIQQSSLENENESVIKEREDLKSLYD 1154
Query: 665 KWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLY 724
I+ E E ++ E ES + + +K + L+ + L+ Y ++ + + L
Sbjct: 1155 SLIKDHEKLELLHERQASEYESLISKHGTLKS-AHKNLEVEHRDLEDRYNQLLKQKGQLE 1213
Query: 725 NALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRI 784
+ + V + LL K E + +KL + R + Y Q+L+E E+LQ H+ +
Sbjct: 1214 DLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYS-QLLKE-TEVLQTDHKNL 1271
Query: 785 RDLEDKTDIQKRQIK 799
+ L + + +++ +++
Sbjct: 1272 KSLLNNSKLEQTRLE 1286
Score = 96.7 bits (239), Expect = 8e-20
Identities = 187/864 (21%), Positives = 376/864 (43%), Gaps = 125/864 (14%)
Query: 33 IQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMK--------- 83
+ +EL K+K+ +L +E ++ +++ + +Q + + ELK +L +E M
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEI-ELK-RLQQENMNLLSDARSAR 306
Query: 84 ----ELQAVRENLIK--QHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIE- 136
EL A+RE ++ + E E+SR K R +I+ K+ + L++ + + T +E
Sbjct: 307 MYRDELDALREKAVRVDKLESEVSR-YKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365
Query: 137 ------AREEARKLFDTERLKLLQEIADLKTA----KKQVDEAL-SNMIQADKIKAGDLR 185
AR + + E L+L ++ D++ +K+++E + NM K
Sbjct: 366 QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425
Query: 186 SEHQSHQ-EAISKIKWESERDIRRLMDEI-KAKDRIIFSLEKELETQTGYVQKLQLQKEA 243
S H + E IS+ SE + L E+ + + LE E ++ T V++L+ ++
Sbjct: 426 SLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDS 485
Query: 244 LD--EQLFLVKEAECNMSSPKREIPG----RAGDGSEHCS--SPDLRRNQKRIAELNATI 295
++ L E E S K EI + ++C S DL + + ++ + T+
Sbjct: 486 VEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL 545
Query: 296 RKLEDRNTLLGDERNELLKRVRET---------EKQCKPLLERNKCLAKRNDELMVSLQR 346
R+ +R + ++ NE L + + E + K + + NK L + E L +
Sbjct: 546 RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK 605
Query: 347 MEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL-------KLQVIEQ 399
+E + + + KE +EK L+ L+ L++ NE + + K++ +EQ
Sbjct: 606 IEFEKRQIKKELEHYKEKGERAEELE--NELHHLEKENELLQKKITNLKITCEKIEALEQ 663
Query: 400 QNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPF--IGYDEDSMDSETSSMASFRTDRT 457
+N EL R+ KL + LD F + + +S++ E S + +
Sbjct: 664 EN--SELERENRKL--------------KKTLDSFKNLTFQLESLEKENSQLDEENLE-L 706
Query: 458 PATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQ-----------EQTGGIIDAE 506
+ S+ + +L ++L E + L++ LL+ G I+ +
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
Query: 507 REAKAQEQLQAEVLRYKAKIEDLEA--TLAQKGQDSHWVEDKQL--FIKRNQEL------ 556
R K E ++ + +++++DLE QK + + K+L K N+ L
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ 826
Query: 557 LEKIEKQ-EAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSAL 615
LEK +KQ E EN RL+Q+ A ++ LE N+++ E+ + + +I + +
Sbjct: 827 LEKDKKQLEKENKRLRQQ---AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES---- 879
Query: 616 QIYCMKEGVKDVNIPDLIKQLDI-LGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIE--- 671
C++ + +L+K+ I + LR + ++ + + EK ++E
Sbjct: 880 ---CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936
Query: 672 -GAEAALHQKMMELESDMEQF-CKIKGYLEEELDYRKQALDQAYMRIQELEATLYN-ALQ 728
E LH + +S + K++ L++ L+ +++ + R++ E+T YN L+
Sbjct: 937 LNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE--ESTNYNQQLR 994
Query: 729 QE--TVIKFGELLSEKQQEELRT----AVEKLRRQMLRKSREYDCQILQERMELLQQAHQ 782
QE TV K E L ++Q EE + + R+S+E ++L+ + L+ + +
Sbjct: 995 QELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI-EVER 1053
Query: 783 RIRDLEDKTDIQKRQIKDLEEKSN 806
L+ + K Q+K LE ++N
Sbjct: 1054 NNATLQAEKQALKTQLKQLETQNN 1077
Score = 95.5 bits (236), Expect = 2e-19
Identities = 180/889 (20%), Positives = 369/889 (41%), Gaps = 189/889 (21%)
Query: 17 VALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQ----------EAKRIRELEQRKH 66
++ +A +D+ + + + + SK+SK+E EK Q + +R ELE H
Sbjct: 576 ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH 635
Query: 67 TVLVTELKAKLHEEKMKELQAVRENL--IKQHEQEMSRTVKVRDGEIQRLKSALCALRDG 124
+ E + +L ++K+ L+ E + ++Q E+ R E ++LK L + ++
Sbjct: 636 HL---EKENELLQKKITNLKITCEKIEALEQENSELER-------ENRKLKKTLDSFKN- 684
Query: 125 SSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDL 184
+E+ E+ D E L+L + + LK A ++ + +++ +L
Sbjct: 685 ------LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL--------QLENKEL 730
Query: 185 RSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEAL 244
SE + ++ + +K S + RL + D L+K LE +Q+L+ + + L
Sbjct: 731 ESEKEQLKKGLELLK-ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 245 D-EQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNT 303
+ E L K E +L+ + KR+ +L + LE +
Sbjct: 790 EMENQTLQKNLE------------------------ELKISSKRLEQLEKENKSLEQETS 825
Query: 304 LLGDERNELLKRVRETEKQCK---PLLERNKC----LAKRNDELMVSLQRMEE---KLKA 353
L ++ +L K + +Q + LE N L K N L + +E +LK
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
Query: 354 VTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKL 413
+ KEN E+ ++ T +K L +L + D +E+ +T+ + N +++LT + EK+
Sbjct: 886 LEKENKELVKRATID--IKTLVTLRE-DLVSEKLKTQ-------QMNNDLEKLTHELEKI 935
Query: 414 IRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAA-- 471
++ + +DE S D + + + T + +E +AA
Sbjct: 936 GLNKER---------------LLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALE 980
Query: 472 ---EESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIED 528
EES +QL +E + +++ Y L+++ D ER ++ + E +++ + ++
Sbjct: 981 ARLEESTNYNQQLRQELKTVKKNYEALKQRQ----DEERMVQSSPPISGEDNKWERESQE 1036
Query: 529 LEATLAQKGQDSHWVEDKQLFIKRN--------QELLEKIEKQEAENHRLQQELQDARDQ 580
L + V+D+ + ++RN Q L ++++ E +N+ LQ ++ + Q
Sbjct: 1037 TTRELLK-------VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1089
Query: 581 NELLEFRNLELEERERRSPPFNLQIHPFSDGV--SALQIYCMKEGVKDVNIPDLIKQLDI 638
L+ +N L+ + + N ++ S + Q+ + +++ N +IK+ +
Sbjct: 1090 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN-ESVIKERED 1148
Query: 639 LGD--NGNLRNEEQVAII---QASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCK 693
L + +++ E++ ++ QAS SL K ++ A L + +LE Q K
Sbjct: 1149 LKSLYDSLIKDHEKLELLHERQASEYESLISKH-GTLKSAHKNLEVEHRDLEDRYNQLLK 1207
Query: 694 IKGYLEE----------------------ELDYRK-----QALDQAYMRI---------- 716
KG LE+ +Y+K L+ Y ++
Sbjct: 1208 QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD 1267
Query: 717 -QELEATLYNALQQETVIK--FGELLSEKQQ---------------EELRTAVEKLRRQM 758
+ L++ L N+ ++T ++ F +L + QQ +L+ +E+ R +
Sbjct: 1268 HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHL 1327
Query: 759 LRKSREYDCQ---ILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEK 804
L + + Q +L++ ME H R DK + +RQ + LEEK
Sbjct: 1328 LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1376
Score = 71.6 bits (174), Expect = 3e-12
Identities = 146/675 (21%), Positives = 281/675 (41%), Gaps = 122/675 (18%)
Query: 182 GDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQK 241
G R+E + H +S +++ IRRL E++ K + ++ELE +++LQ +
Sbjct: 239 GMKRTESRQH---LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN 295
Query: 242 -----------------EALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRN 284
+AL E+ V + E +S K + D+
Sbjct: 296 MNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL-------------HDIEFY 342
Query: 285 QKRIAELNATIRKLEDRNTLLGDE------RNELLKRVRETEKQCKPLL---------ER 329
+ R+ EL + L + T+L D+ R++ L + + Q K L +R
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDR 402
Query: 330 NKC--LAKRNDEL-MVSLQRMEEKLKAVTKENSEMREKITSHPPLKKL-KSLNDLDQA-- 383
K L + N L M Q M+E L + R S P K L +N+L +
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 462
Query: 384 -NEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRK-HRRSSKPIKRPVLDPFIGYDEDS 441
E E + L V E + +D + + K+++ K ++R SK ++ +L+ I ++ S
Sbjct: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE--ILENEIVQEKQS 520
Query: 442 MDSETSSMASFRTDRTPATPDDDLDESLAA--EESELRFRQLTKEYQALQRAYALLQEQT 499
+ + + ++ L++++ E SE + + L +E + L + + L++++
Sbjct: 521 LQNCQNLSKDLMKEKA------QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS 574
Query: 500 GGIIDAEREAKAQEQ----LQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQE 555
I AE K E+ L + +K+ +E Q ++ ++K +R +E
Sbjct: 575 Q--ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG---ERAEE 629
Query: 556 LLEKIEKQEAENHRLQQELQDAR---DQNELLEFRNLELEERERRSPPFNLQIHPFSDGV 612
L ++ E EN LQ+++ + + ++ E LE N ELE R+
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRK--------------- 674
Query: 613 SALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEG 672
+K+ + + +L QL+ L + +EE + + + L A + Q++
Sbjct: 675 -------LKKTLD--SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725
Query: 673 AEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETV 732
L + +L+ +E K E L+ Q LD + Q L+ TL N+ +
Sbjct: 726 ENKELESEKEQLKKGLE-LLKASFKKTERLEVSYQGLD---IENQRLQKTLENSNK---- 777
Query: 733 IKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTD 792
K +L SE Q E + Q L+K+ E + +I +R+E L++ + + LE +T
Sbjct: 778 -KIQQLESELQDLE-------MENQTLQKNLE-ELKISSKRLEQLEKEN---KSLEQETS 825
Query: 793 IQKRQIKDLEEKSNR 807
++ K LE+++ R
Sbjct: 826 QLEKDKKQLEKENKR 840
Score = 65.9 bits (159), Expect = 1e-10
Identities = 121/614 (19%), Positives = 248/614 (40%), Gaps = 99/614 (16%)
Query: 265 IPGRAGDGSEHCSSPDLRRNQKR------IAELNATIRKL----EDRNTLLGDERNEL-- 312
+P + C SP ++R + R +A+ A IR+L E++ L D + EL
Sbjct: 224 LPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQ 283
Query: 313 ----LKRVRE----------TEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKEN 358
LKR+++ + + + L+ + A R D+L + R +E+L +
Sbjct: 284 MEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYK 343
Query: 359 SEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNII---------DELTRD 409
+ + E + L + K++ L+ E KL +E++N+ E D
Sbjct: 344 ARVEELKEDNQVLLETKTM--LEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD 401
Query: 410 REKLIRRRKHRRSSKPIKRPVLDP--FIGYDEDSMDSETSSMASFRTDRTPATPDDDLDE 467
R+K+ + + + ++ +D +G++ + + RT P +
Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS---------RTSELSEAPQ----K 448
Query: 468 SLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIE 527
SL E +EL +L K Q ++E + E A +++ E R K+E
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 528 DLEATLAQKGQ--------DSHWVEDKQLFIKRNQELLEKIEKQ----EAENHRLQQELQ 575
LE + Q+ Q +++K K + L E E+Q E EN L Q +
Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
Query: 576 DARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQ 635
R ++++ +++ E+ + + I S +S ++ K +K K+
Sbjct: 569 SLRQRSQI--SAEARVKDIEKENKILHESIKETSSKLSKIEF--EKRQIK--------KE 616
Query: 636 LDILGDNG----NLRNE------EQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELE 685
L+ + G L NE E + + T L + + I+ +E + L ++ +L+
Sbjct: 617 LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
Query: 686 SDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQE 745
++ F + L E L+ LD+ + ++ +L A + ++ E ++E
Sbjct: 677 KTLDSFKNLTFQL-ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKE 735
Query: 746 ELRTAVEKLRRQMLRKSR--------EYDCQILQERME----LLQQAHQRIRDLEDKTDI 793
+L+ +E L+ + R + + Q LQ+ +E +QQ ++DLE +
Sbjct: 736 QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQT 795
Query: 794 QKRQIKDLEEKSNR 807
++ +++L+ S R
Sbjct: 796 LQKNLEELKISSKR 809
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 107 bits (267), Expect = 4e-23
Identities = 170/854 (19%), Positives = 377/854 (44%), Gaps = 78/854 (9%)
Query: 5 GRNKGEKPEALIVALQAANEDLRTKLTDIQI---ELHQEKSKVSKLEREKTQEAKRIREL 61
G E + ++ L+ N+ L + +++ + SK+ K+E+E + +K++ L
Sbjct: 451 GHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEIL 510
Query: 62 E----QRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSA 117
E Q K ++ + L ++ MKE +A E I+ + R +K+ + E + L
Sbjct: 511 ENEIVQEKQSLQNCQ---NLSKDLMKE-KAQLEKTIETLRENSERQIKILEQENEHLNQT 566
Query: 118 LCALRDGSSDKVRTALTIEAR----EEARKLFDTERLKLLQEIADLKTAKKQVDEALSNM 173
+ +LR R+ ++ EAR E+ K+ + +++ ++ K+Q+ + L +
Sbjct: 567 VSSLRQ------RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY 620
Query: 174 IQ----ADKI--KAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKEL 227
+ A+++ + L E++ Q+ I+ +K E+ I L E +R L+K L
Sbjct: 621 KEKGERAEELENELHHLEKENELLQKKITNLKITCEK-IEALEQENSELERENRKLKKTL 679
Query: 228 ET---QTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPD---- 280
++ T ++ L+ + LDE+ ++ ++ ++ + E S +
Sbjct: 680 DSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKK 739
Query: 281 ----LRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKR 336
L+ + K+ L + + L+ N L K++++ E + + L N+ L K
Sbjct: 740 GLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN 799
Query: 337 NDELMVS---LQRMEEKLKAVTKENSEM-REKITSHPPLKKLKSLNDLDQANEEQETEFL 392
+EL +S L+++E++ K++ +E S++ ++K K+L+ ++ E+ +
Sbjct: 800 LEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENN--V 857
Query: 393 KLQVIEQQN--IIDELTRDREKLIRRRKHRRSSKP-IKRPVLD--PFIGYDEDSMDSETS 447
K+ +E++N + E+ +E +R ++ + +K +KR +D + ED + SE
Sbjct: 858 KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED-LVSEKL 916
Query: 448 SMASFRTDRTPATPDDDL----DESLAAEE--SELRFRQLTKEYQALQRAYALLQEQTGG 501
D T + + E L +E ++ R++ L + ++ + ++E+
Sbjct: 917 KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIA 976
Query: 502 IIDA--EREAKAQEQLQAEVLRYKAKIEDL-----EATLAQ-----KGQDSHWVEDKQLF 549
++A E +QL+ E+ K E L E + Q G+D+ W + Q
Sbjct: 977 ALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQET 1036
Query: 550 IKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEER----ERRSPPFNLQI 605
+ ++ +++ + E N LQ E Q + Q + LE +N L+ + +R++ Q
Sbjct: 1037 TRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1096
Query: 606 HPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEK 665
+ LQ+ + ++ + QL L +L NE + I + + SL +
Sbjct: 1097 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQL--LIQQSSLENENESVIKEREDLKSLYDS 1154
Query: 666 WIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYN 725
I+ E E ++ E ES + + +K + L+ + L+ Y ++ + + L +
Sbjct: 1155 LIKDHEKLELLHERQASEYESLISKHGTLKS-AHKNLEVEHRDLEDRYNQLLKQKGQLED 1213
Query: 726 ALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIR 785
+ V + LL K E + +KL + R + Y Q+L+E E+LQ H+ ++
Sbjct: 1214 LEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYS-QLLKE-TEVLQTDHKNLK 1271
Query: 786 DLEDKTDIQKRQIK 799
L + + +++ +++
Sbjct: 1272 SLLNNSKLEQTRLE 1285
Score = 96.3 bits (238), Expect = 1e-19
Identities = 186/863 (21%), Positives = 374/863 (43%), Gaps = 124/863 (14%)
Query: 33 IQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMK--------- 83
+ +EL K+K+ +L +E ++ +++ + +Q + + ELK +L +E M
Sbjct: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEI-ELK-RLQQENMNLLSDARSAR 306
Query: 84 ----ELQAVRENLIK--QHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIE- 136
EL A+RE ++ + E E+SR K R +I+ K+ + L++ + + T +E
Sbjct: 307 MYRDELDALREKAVRVDKLESEVSR-YKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365
Query: 137 ------AREEARKLFDTERLKLLQEIADLKTA----KKQVDEAL-SNMIQADKIKAGDLR 185
AR + + E L+L ++ D++ +K+++E + NM K
Sbjct: 366 QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDE 425
Query: 186 SEHQSHQ-EAISKIKWESERDIRRLMDEI-KAKDRIIFSLEKELETQTGYVQKLQLQKEA 243
S H + E IS+ SE + L E+ + + LE E ++ T V++L+ ++
Sbjct: 426 SLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDS 485
Query: 244 LD--EQLFLVKEAECNMSSPKREIPG----RAGDGSEHCS--SPDLRRNQKRIAELNATI 295
++ L E E S K EI + ++C S DL + + ++ + T+
Sbjct: 486 VEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL 545
Query: 296 RKLEDRNTLLGDERNELLKRVRET---------EKQCKPLLERNKCLAKRNDELMVSLQR 346
R+ +R + ++ NE L + + E + K + + NK L + E L +
Sbjct: 546 RENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSK 605
Query: 347 MEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL-------KLQVIEQ 399
+E + + + KE +EK L+ L+ L++ NE + + K++ +EQ
Sbjct: 606 IEFEKRQIKKELEHYKEKGERAEELE--NELHHLEKENELLQKKITNLKITCEKIEALEQ 663
Query: 400 QNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPF--IGYDEDSMDSETSSMASFRTDRT 457
+N EL R+ KL + LD F + + +S++ E S + +
Sbjct: 664 EN--SELERENRKL--------------KKTLDSFKNLTFQLESLEKENSQLDEENLE-L 706
Query: 458 PATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQ-----------EQTGGIIDAE 506
+ S+ + +L ++L E + L++ LL+ G I+ +
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
Query: 507 REAKAQEQLQAEVLRYKAKIEDLEA--TLAQKGQDSHWVEDKQL--FIKRNQEL------ 556
R K E ++ + +++++DLE QK + + K+L K N+ L
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQ 826
Query: 557 LEKIEKQ-EAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSAL 615
LEK +KQ E EN RL+Q+ A ++ LE N+++ E+ + + +I + +
Sbjct: 827 LEKDKKQLEKENKRLRQQ---AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKES---- 879
Query: 616 QIYCMKEGVKDVNIPDLIKQLDI-LGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIE--- 671
C++ + +L+K+ I + LR + ++ + + EK ++E
Sbjct: 880 ---CVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG 936
Query: 672 -GAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYN-ALQQ 729
E LH + + K++ L++ L+ +++ + R++ E+T YN L+Q
Sbjct: 937 LNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLE--ESTNYNQQLRQ 994
Query: 730 E--TVIKFGELLSEKQQEELRT----AVEKLRRQMLRKSREYDCQILQERMELLQQAHQR 783
E TV K E L ++Q EE + + R+S+E ++L+ + L+ + +
Sbjct: 995 ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI-EVERN 1053
Query: 784 IRDLEDKTDIQKRQIKDLEEKSN 806
L+ + K Q+K LE ++N
Sbjct: 1054 NATLQAEKQALKTQLKQLETQNN 1076
Score = 92.8 bits (229), Expect = 1e-18
Identities = 181/889 (20%), Positives = 370/889 (41%), Gaps = 190/889 (21%)
Query: 17 VALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQ----------EAKRIRELEQRKH 66
++ +A +D+ + + + + SK+SK+E EK Q + +R ELE H
Sbjct: 576 ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH 635
Query: 67 TVLVTELKAKLHEEKMKELQAVRENL--IKQHEQEMSRTVKVRDGEIQRLKSALCALRDG 124
+ E + +L ++K+ L+ E + ++Q E+ R E ++LK L + ++
Sbjct: 636 HL---EKENELLQKKITNLKITCEKIEALEQENSELER-------ENRKLKKTLDSFKN- 684
Query: 125 SSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDL 184
+E+ E+ D E L+L + + LK A ++ + +++ +L
Sbjct: 685 ------LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL--------QLENKEL 730
Query: 185 RSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEAL 244
SE + ++ + +K S + RL + D L+K LE +Q+L+ + + L
Sbjct: 731 ESEKEQLKKGLELLK-ASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 245 D-EQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNT 303
+ E L K E +L+ + KR+ +L + LE +
Sbjct: 790 EMENQTLQKNLE------------------------ELKISSKRLEQLEKENKSLEQETS 825
Query: 304 LLGDERNELLKRVRETEKQCK---PLLERNKC----LAKRNDELMVSLQRMEE---KLKA 353
L ++ +L K + +Q + LE N L K N L + +E +LK
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
Query: 354 VTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKL 413
+ KEN E+ ++ T +K L +L + D +E+ +T+ + N +++LT + EK+
Sbjct: 886 LEKENKELVKRATID--IKTLVTLRE-DLVSEKLKTQ-------QMNNDLEKLTHELEKI 935
Query: 414 IRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAA-- 471
++ + +DE S D + S + + T + +E +AA
Sbjct: 936 GLNKER---------------LLHDEQSTDDRYKLLES-KLESTLKKSLEIKEEKIAALE 979
Query: 472 ---EESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIED 528
EES +QL +E + +++ Y L+++ D ER ++ + E +++ + ++
Sbjct: 980 ARLEESTNYNQQLRQELKTVKKNYEALKQRQ----DEERMVQSSPPISGEDNKWERESQE 1035
Query: 529 LEATLAQKGQDSHWVEDKQLFIKRN--------QELLEKIEKQEAENHRLQQELQDARDQ 580
L + V+D+ + ++RN Q L ++++ E +N+ LQ ++ + Q
Sbjct: 1036 TTRELLK-------VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1088
Query: 581 NELLEFRNLELEERERRSPPFNLQIHPFSDGV--SALQIYCMKEGVKDVNIPDLIKQLDI 638
L+ +N L+ + + N ++ S + Q+ + +++ N +IK+ +
Sbjct: 1089 TVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN-ESVIKERED 1147
Query: 639 LGD--NGNLRNEEQVAII---QASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCK 693
L + +++ E++ ++ QAS SL K ++ A L + +LE Q K
Sbjct: 1148 LKSLYDSLIKDHEKLELLHERQASEYESLISKH-GTLKSAHKNLEVEHRDLEDRYNQLLK 1206
Query: 694 IKGYLEE----------------------ELDYRK-----QALDQAYMRI---------- 716
KG LE+ +Y+K L+ Y ++
Sbjct: 1207 QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTD 1266
Query: 717 -QELEATLYNALQQETVIK--FGELLSEKQQ---------------EELRTAVEKLRRQM 758
+ L++ L N+ ++T ++ F +L + QQ +L+ +E+ R +
Sbjct: 1267 HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHL 1326
Query: 759 LRKSREYDCQ---ILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEK 804
L + + Q +L++ ME H R DK + +RQ + LEEK
Sbjct: 1327 LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375
Score = 71.6 bits (174), Expect = 3e-12
Identities = 146/675 (21%), Positives = 281/675 (41%), Gaps = 122/675 (18%)
Query: 182 GDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQK 241
G R+E + H +S +++ IRRL E++ K + ++ELE +++LQ +
Sbjct: 239 GMKRTESRQH---LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN 295
Query: 242 -----------------EALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRN 284
+AL E+ V + E +S K + D+
Sbjct: 296 MNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERL-------------HDIEFY 342
Query: 285 QKRIAELNATIRKLEDRNTLLGDE------RNELLKRVRETEKQCKPLL---------ER 329
+ R+ EL + L + T+L D+ R++ L + + Q K L +R
Sbjct: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDR 402
Query: 330 NKC--LAKRNDEL-MVSLQRMEEKLKAVTKENSEMREKITSHPPLKKL-KSLNDLDQA-- 383
K L + N L M Q M+E L + R S P K L +N+L +
Sbjct: 403 KKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRL 462
Query: 384 -NEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRK-HRRSSKPIKRPVLDPFIGYDEDS 441
E E + L V E + +D + + K+++ K ++R SK ++ +L+ I ++ S
Sbjct: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE--ILENEIVQEKQS 520
Query: 442 MDSETSSMASFRTDRTPATPDDDLDESLAA--EESELRFRQLTKEYQALQRAYALLQEQT 499
+ + + ++ L++++ E SE + + L +E + L + + L++++
Sbjct: 521 LQNCQNLSKDLMKEKA------QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRS 574
Query: 500 GGIIDAEREAKAQEQ----LQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQE 555
I AE K E+ L + +K+ +E Q ++ ++K +R +E
Sbjct: 575 Q--ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG---ERAEE 629
Query: 556 LLEKIEKQEAENHRLQQELQDAR---DQNELLEFRNLELEERERRSPPFNLQIHPFSDGV 612
L ++ E EN LQ+++ + + ++ E LE N ELE R+
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRK--------------- 674
Query: 613 SALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEG 672
+K+ + + +L QL+ L + +EE + + + L A + Q++
Sbjct: 675 -------LKKTLD--SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQL 725
Query: 673 AEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETV 732
L + +L+ +E K E L+ Q LD + Q L+ TL N+ +
Sbjct: 726 ENKELESEKEQLKKGLE-LLKASFKKTERLEVSYQGLD---IENQRLQKTLENSNK---- 777
Query: 733 IKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTD 792
K +L SE Q E + Q L+K+ E + +I +R+E L++ + + LE +T
Sbjct: 778 -KIQQLESELQDLE-------MENQTLQKNLE-ELKISSKRLEQLEKEN---KSLEQETS 825
Query: 793 IQKRQIKDLEEKSNR 807
++ K LE+++ R
Sbjct: 826 QLEKDKKQLEKENKR 840
Score = 65.9 bits (159), Expect = 1e-10
Identities = 121/614 (19%), Positives = 248/614 (40%), Gaps = 99/614 (16%)
Query: 265 IPGRAGDGSEHCSSPDLRRNQKR------IAELNATIRKL----EDRNTLLGDERNEL-- 312
+P + C SP ++R + R +A+ A IR+L E++ L D + EL
Sbjct: 224 LPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQ 283
Query: 313 ----LKRVRE----------TEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKEN 358
LKR+++ + + + L+ + A R D+L + R +E+L +
Sbjct: 284 MEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYK 343
Query: 359 SEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNII---------DELTRD 409
+ + E + L + K++ L+ E KL +E++N+ E D
Sbjct: 344 ARVEELKEDNQVLLETKTM--LEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD 401
Query: 410 REKLIRRRKHRRSSKPIKRPVLDP--FIGYDEDSMDSETSSMASFRTDRTPATPDDDLDE 467
R+K+ + + + ++ +D +G++ + + RT P +
Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS---------RTSELSEAPQ----K 448
Query: 468 SLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIE 527
SL E +EL +L K Q ++E + E A +++ E R K+E
Sbjct: 449 SLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE 508
Query: 528 DLEATLAQKGQ--------DSHWVEDKQLFIKRNQELLEKIEKQ----EAENHRLQQELQ 575
LE + Q+ Q +++K K + L E E+Q E EN L Q +
Sbjct: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
Query: 576 DARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQ 635
R ++++ +++ E+ + + I S +S ++ K +K K+
Sbjct: 569 SLRQRSQI--SAEARVKDIEKENKILHESIKETSSKLSKIEF--EKRQIK--------KE 616
Query: 636 LDILGDNG----NLRNE------EQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELE 685
L+ + G L NE E + + T L + + I+ +E + L ++ +L+
Sbjct: 617 LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
Query: 686 SDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQE 745
++ F + L E L+ LD+ + ++ +L A + ++ E ++E
Sbjct: 677 KTLDSFKNLTFQL-ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKE 735
Query: 746 ELRTAVEKLRRQMLRKSR--------EYDCQILQERME----LLQQAHQRIRDLEDKTDI 793
+L+ +E L+ + R + + Q LQ+ +E +QQ ++DLE +
Sbjct: 736 QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQT 795
Query: 794 QKRQIKDLEEKSNR 807
++ +++L+ S R
Sbjct: 796 LQKNLEELKISSKR 809
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 104 bits (259), Expect = 4e-22
Identities = 189/846 (22%), Positives = 370/846 (43%), Gaps = 115/846 (13%)
Query: 10 EKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHT-- 67
EK + +I + + +DL+ +L ++ + + K+E ++ K I+ELE ++ T
Sbjct: 1532 EKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQ----KLIKELEGQRETQR 1587
Query: 68 VLVTELKAKLHEEKMKELQAVRENL--IKQHEQEMSRTVKVRDGEIQRLKSALCALRDGS 125
V +T L L EE+ +ELQA + ++ H ++R ++ RD E++ + + L+
Sbjct: 1588 VALTHLTLDL-EERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQ--- 1643
Query: 126 SDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLR 185
K +E R++ L ER+++L++ +T K ++E L + + + + +L
Sbjct: 1644 RQKEHLTQDLERRDQELML-QKERIQVLEDQRTRQT--KILEEDLEQIKLSLRERGRELT 1700
Query: 186 SEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALD 245
++ Q QE + K S+ R ++ +K I+ EKE+E Q ++ +LQ K+ L+
Sbjct: 1701 TQRQLMQERAEEGKGPSKAQ-RGSLEHMKL---ILRDKEKEVECQQEHIHELQELKDQLE 1756
Query: 246 EQLF----LVKEAECNMSSPKREI---------PGRAGDGSEHCSSPDLRRNQKRIAELN 292
+QL V E +S ++EI G+ E L Q+ +A+ +
Sbjct: 1757 QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRD 1816
Query: 293 ATIRKLE-DRNTLLGDERNELLKRVRETEKQCKPLLER-NKCLAKRNDELM---VSLQRM 347
+ L+ ++ G E +RV+E + LE+ + L +R+ EL +R+
Sbjct: 1817 QELEALQQEQQQAQGQE-----ERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRL 1871
Query: 348 EEKLKAVTKENSEMRE-----KITSHPPLKKLKSLND--LDQANE-EQETEFLKLQVIEQ 399
EE+L + + E + S K L +L +QA E E ET L+ ++
Sbjct: 1872 EEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQA 1931
Query: 400 QNIIDELTRDREKL---IRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDR 456
Q ++ E ++ E L + +H+ + + L +G ++ +
Sbjct: 1932 QAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGK----------- 1980
Query: 457 TPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQ 516
E E++EL R L LQ + Q + + +A R + + +Q
Sbjct: 1981 ----------EQHLLEQAELS-RSLEASTATLQASLDACQAHSRQLEEALRIQEGE--IQ 2027
Query: 517 AEVLRYKAKIEDLEATLAQKGQD-SHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQ 575
+ LRY+ ++ L+ LAQ+ ++ H E +QL K + +++ QE +N ++E +
Sbjct: 2028 DQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEE 2087
Query: 576 DARDQNELL----------EFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVK 625
+ R ++ + E LEL E ++R+ NL+ P S S ++ +K
Sbjct: 2088 EIRGLHQSVRELQLTLAQKEQEILELRETQQRN---NLEALPHSHKTSPMEEQSLK---L 2141
Query: 626 DVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELE 685
D P L ++L+ L LR E I LA + Q + + ++L + M L+
Sbjct: 2142 DSLEPRLQRELERL--QAALRQTEAREIEWREKAQDLALS-LAQTKASVSSLQEVAMFLQ 2198
Query: 686 SDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQE 745
+ + + + L++EL+ ++AL++ + +T + E ++ GE +S + E
Sbjct: 2199 ASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGE-VSGVEAE 2257
Query: 746 ELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRI---RDLEDKTDIQKRQIKDLE 802
+EK Q ++R+E LQQA R+ R + ++Q R +
Sbjct: 2258 PSPDGMEK--------------QSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQV 2303
Query: 803 EKSNRK 808
E+ RK
Sbjct: 2304 ERERRK 2309
Score = 99.0 bits (245), Expect = 2e-20
Identities = 192/892 (21%), Positives = 376/892 (42%), Gaps = 121/892 (13%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRK 65
R++ +K E + +A + T+L D+Q +L Q + + SK E ++ + EL +
Sbjct: 1263 RDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETM 1322
Query: 66 HTVLVTELKAKLH----EEKMKELQAVRENLIKQHE-------------------QEMSR 102
++ +A+L + + + LQA +ENL Q E +E R
Sbjct: 1323 ASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLR 1382
Query: 103 T----VKVRDGEIQRLKSALCALRDGSSDKVR------------TALTIEAREEARKLF- 145
T +K+++ E++ + AL++ KV T E EE L
Sbjct: 1383 TARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRG 1442
Query: 146 ---DTERLKLLQEIA------DLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAIS 196
+ E+ + +Q+ A DLK ++VD + + +K ++ L + QE
Sbjct: 1443 QIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSV-LEHLPMAVQEREQ 1501
Query: 197 KIKWESERDIRRLMDEIKAKDRII----FSLEKE---LETQTGYVQKLQLQKEALDEQLF 249
K+ + E+ IR L + + + ++ LEK+ +E+Q G VQ L+ Q L+
Sbjct: 1502 KLTVQREQ-IRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLAL 1560
Query: 250 LVKEAECNMSSPKREIPGRAGDGSEHCSSP-----DLRRNQKRIAELNATIRKLEDRNTL 304
++E M ++ I G + DL + + ++ I LE +T+
Sbjct: 1561 ELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTV 1620
Query: 305 LGDERNELLKRVRETEKQCKPLLERNKCLA----KRNDELMVSLQRMEEKLKAVTKENSE 360
L E E + V+ +Q + L + + L +R+ ELM+ +R++ T++
Sbjct: 1621 LARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKI 1680
Query: 361 MRE-----KITSHPPLKKLKSLNDLDQANEEQETEFLKLQ--VIEQQNIIDELTRDREKL 413
+ E K++ ++L + L Q E+ K Q +E +I RD+EK
Sbjct: 1681 LEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI---LRDKEKE 1737
Query: 414 IR-RRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAE 472
+ +++H + +K + G ETS + S R ++ L E A E
Sbjct: 1738 VECQQEHIHELQELKDQLEQQLQGLHRKV--GETSLLLSQR-EQEIVVLQQQLQE--ARE 1792
Query: 473 ESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEAT 532
+ EL+ + L + QRA A ++ + +++A+ QE+ R K K + L+
Sbjct: 1793 QGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE------RVKEKADALQGA 1846
Query: 533 LAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHR----LQQELQDARDQNELLEFRN 588
L Q ++++ ++ ++E ++E++ A R L++ L D R ++ E
Sbjct: 1847 LEQAHMT---LKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKAL 1903
Query: 589 LELEER-ERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRN 647
L L+++ ++ ++ D Q +KE +++ + ++ + R+
Sbjct: 1904 LALQQQCAEQAQEHEVETRALQDSWLQAQAV-LKERDQELEA--------LRAESQSSRH 1954
Query: 648 EEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQ 707
+E+ A +A + K ++G E L ++ EL +E + +
Sbjct: 1955 QEEAARARAEALQEALGKAHAALQGKEQHLLEQA-ELSRSLEASTATLQASLDACQAHSR 2013
Query: 708 ALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDC 767
L++A +RIQE E + QE V + + L+++ EELR E R Q+L KS
Sbjct: 2014 QLEEA-LRIQEGEIQDQDLRYQEDVQQLQQALAQRD-EELRHQQE--REQLLEKSLAQRV 2069
Query: 768 Q--ILQERMELLQQA--------HQRIRDLEDKTDIQKRQIKDLEEKSNRKH 809
Q ++QE+ L Q+ HQ +R+L+ ++++I +L E R +
Sbjct: 2070 QENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNN 2121
Score = 88.6 bits (218), Expect = 2e-17
Identities = 169/798 (21%), Positives = 351/798 (43%), Gaps = 85/798 (10%)
Query: 24 EDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELE------QRKHTVLVTELKAKL 77
EDLRT + ++++ + +S ERE+ Q + EL+ +++ L+T+ A+
Sbjct: 1379 EDLRTARSALKLKNEEVES-----ERERAQALQEQGELKVAQGKALQENLALLTQTLAE- 1432
Query: 78 HEEKMKELQAVRENLIKQHEQE------MSRTVKVRDGEIQRLKSALCALRDGSSDKVRT 131
EE+++ L+ + L KQ E + +S +K R+ E+ + + L S
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL 1492
Query: 132 ALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSH 191
+ ++ RE+ + E+++ L++ D +T + ++ L + + D++ R + Q
Sbjct: 1493 PMAVQEREQ-KLTVQREQIRELEK--DRETQRNVLEHQLLELEKKDQMIESQ-RGQVQDL 1548
Query: 192 QEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQ----TGYVQKLQLQKEALDEQ 247
++ + ++ + ++ +++ + ++I LE + ETQ T L+ + + L Q
Sbjct: 1549 KKQLVTLECLA-LELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQ 1607
Query: 248 LFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGD 307
+ + E + + RE+ R D + Q++ L + + D+ +L
Sbjct: 1608 SSQIHDLESHSTVLARELQER--DQEVKSQREQIEELQRQKEHLTQDLER-RDQELMLQK 1664
Query: 308 ERNELL--KRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKI 365
ER ++L +R R+T+ + L + L +R EL Q M+E+ + + R
Sbjct: 1665 ERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGS- 1723
Query: 366 TSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRR---S 422
L+ +K L ++E+E E + + E Q + D+L + + L R+ S
Sbjct: 1724 -----LEHMK----LILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLS 1774
Query: 423 SKPIKRPVLDPFIGYDEDSMDSETSSMAS--FRTDRTPATPDDDLD----ESLAAEESEL 476
+ + VL + + + + S+ S R A D +L+ E A+ E
Sbjct: 1775 QREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Query: 477 RFRQLTKEYQ-ALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQ 535
R ++ Q AL++A+ L+E+ G + D + +A+ +L+ E+ +++ LE L
Sbjct: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKEQAR---RLEEELAVEGRRVQALEEVLGD 1891
Query: 536 KGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERE 595
+S E ++ + Q+ E+ ++ E E LQ A+ +L+ R+ ELE
Sbjct: 1892 LRAESR--EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQ---AVLKERDQELEALR 1946
Query: 596 RRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRN-EEQVAII 654
S Q ALQ E + + K+ +L R+ E A +
Sbjct: 1947 AESQSSRHQEEAARARAEALQ-----EALGKAHAALQGKEQHLLEQAELSRSLEASTATL 2001
Query: 655 QASTVLSLAEKWIQQIEGA----EAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALD 710
QAS L + +Q+E A E + + + + D++Q + +EEL ++++
Sbjct: 2002 QAS--LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQE--- 2056
Query: 711 QAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELR---TAVEKLRRQMLRKSRE-YD 766
R Q LE +L +Q+ + + L E+++EE+R +V +L+ + +K +E +
Sbjct: 2057 ----REQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILE 2112
Query: 767 CQILQER--MELLQQAHQ 782
+ Q+R +E L +H+
Sbjct: 2113 LRETQQRNNLEALPHSHK 2130
Score = 88.2 bits (217), Expect = 3e-17
Identities = 181/887 (20%), Positives = 364/887 (41%), Gaps = 132/887 (14%)
Query: 13 EALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQ---RKHTVL 69
EA + + A +L+ L DIQ E + + K+S+ ++ ++ +L Q R+ VL
Sbjct: 665 EAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVL 724
Query: 70 VTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSS--- 126
++ K + K VR +++ Q+++ ++ + L+S+L + +S
Sbjct: 725 ARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIE 784
Query: 127 -DKVRTALTIEAREEARKLFDTE-RLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDL 184
K + + I+ +A+++ E R L+ + A+++ D A + QA++ L
Sbjct: 785 VTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844
Query: 185 RSEHQSHQEAISKI--KWESERDIRR--LMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ 240
+ +H++ ++++ KWE ER + L +++ +R LE L+ Q ++ +Q Q
Sbjct: 845 EQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQ 904
Query: 241 KEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPD-LRRNQKRIAELNATIRKLE 299
+E E+ + A C M + E S + L + QK +A+ + + +L
Sbjct: 905 RE---EERTQAESALCQMQLETEK---------ERVSLLETLLQTQKELADASQQLERLR 952
Query: 300 DRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENS 359
D + + LK E++ +L+ A+R EL + ++ + L A+ +E+S
Sbjct: 953 Q------DMKVQKLK-----EQETTGILQTQLQEAQR--ELKEAARQHRDDLAALQEESS 999
Query: 360 EM-REKITSHPPLKKLKS---LNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKL-- 413
+ ++K+ ++ LKS D Q EQE + + E I EL R++ L
Sbjct: 1000 SLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL 1059
Query: 414 -IRRRKHR----RSSKPIKRPVLDPFIGYDEDSMDSE---TSSMASFRTDRTPATPDDDL 465
+ ++ R + + I++ L +++ + ++ M R + D
Sbjct: 1060 SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLA 1119
Query: 466 DESLAAEE---SELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRY 522
E+ EE S + +QL A + A LQ + +++ EA A EQ +
Sbjct: 1120 QEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRST-ESQLEALAAEQQPGNQAQA 1178
Query: 523 KAKIEDLEATLAQK-------------GQDSH---WVED------KQLFIKRNQELLEKI 560
+A++ L + L Q G DS W + + LF +
Sbjct: 1179 QAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSA 1238
Query: 561 EKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIH-------------- 606
E + H+L Q+L + ++L + +LEER + Q+H
Sbjct: 1239 EAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQ 1298
Query: 607 ------------------PFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNE 648
+ +++LQ + ++ + + L +N + E
Sbjct: 1299 EEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVE 1358
Query: 649 E-QVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDME--QFCKIKGYLE----EE 701
Q A+++A S A + + A +AL K E+ES+ E Q + +G L+ +
Sbjct: 1359 HLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKA 1418
Query: 702 LDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRK 761
L L Q +E TL +Q+ EKQ+E + A+E L + ++
Sbjct: 1419 LQENLALLTQTLAEREEEVETLRGQIQE----------LEKQREMQKAALELLSLDLKKR 1468
Query: 762 SREYD-----CQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEE 803
++E D Q L++ +L+ +++ E K +Q+ QI++LE+
Sbjct: 1469 NQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEK 1515
Score = 77.8 bits (190), Expect = 4e-14
Identities = 173/883 (19%), Positives = 371/883 (42%), Gaps = 144/883 (16%)
Query: 19 LQAANEDLRT----------KLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTV 68
LQ A E+LR +L + +EL Q + ++ ++E+ QE + E+ +
Sbjct: 468 LQKAREELRQQLEVLEQEAWRLRRVNVEL-QLQGDSAQGQKEEQQEELHLAVRERERLQE 526
Query: 69 LVTELKAKLHEEKMKELQAVRE---------NLIKQHEQEMSRTVKVRDGEIQRLKSALC 119
++ L+AK E + EL +RE L++Q + E++ + + I L S+
Sbjct: 527 MLMGLEAK-QSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSEN 585
Query: 120 ALRDGSSDKVRTALTIEAREEARKLFDT---ERLKLLQEIADLKTAKKQVDEALSNMIQA 176
L+ +D A+ + A EA L ++L L+E ++ + E N +Q
Sbjct: 586 TLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQV 645
Query: 177 DKIKAGDLRS---EHQSHQEA----ISKIKWESERDIRRLMDEIKAKDRIIFSLEKELET 229
D +A R E +H EA + E + D+R + +E + + + + E
Sbjct: 646 DLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA 705
Query: 230 QTGYVQKLQLQKEALDEQLF-LVKEAECNMSSPKR-EIPGRAGDGSEHCSSPDLRRNQKR 287
T +++L + + +E L V+E E + E+ +A + + L+
Sbjct: 706 ATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSA 765
Query: 288 IAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERN-KCLAKRNDELMVSLQR 346
L +++ + + +N+++ + +L ++ +T Q K +++ +CL EL +
Sbjct: 766 KELLESSLFEAQQQNSVIEVTKGQLEVQI-QTVTQAKEVIQGEVRCLKL---ELDTERSQ 821
Query: 347 MEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDEL 406
E++ A ++ ++ ++ + +K +++Q E+ E E Q E ++ L
Sbjct: 822 AEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQ-ELAKALESL 880
Query: 407 TRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLD 466
R++ +L R K +++ ++ E+ S++ + + L
Sbjct: 881 EREKMELEMRLKEQQTE-------MEAIQAQREEERTQAESALCQMQLETEKERVS--LL 931
Query: 467 ESLAAEESELR--FRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKA 524
E+L + EL +QL + Q + + L +++T GI+ + + +AQ +L+ +++
Sbjct: 932 ETLLQTQKELADASQQLERLRQDM-KVQKLKEQETTGILQTQLQ-EAQRELKEAARQHR- 988
Query: 525 KIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELL 584
+DL A + + S ++DK K+ ++L ++ Q+ ++QE+Q+ E
Sbjct: 989 --DDLAAL---QEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQE--KLRETQ 1041
Query: 585 EFRNLELE-ERERRSPPFNLQ-------IHPFSDGVSALQIYCMKEGVKDVN-------- 628
E+ ++ E ERE+ S +L + +D + ++ +++ +++
Sbjct: 1042 EYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSA 1101
Query: 629 IPDLI------KQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMM 682
+L+ K+ D L L E + + I + A W Q+ + A+ L ++
Sbjct: 1102 QMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQL--RASLWAQEAKAAQ--LQLRLR 1157
Query: 683 ELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQ------------- 729
ES +E L E QA QA + A+LY+ALQQ
Sbjct: 1158 STESQLEA-------LAAEQQPGNQAQAQAQL------ASLYSALQQALGSVCESRPELS 1204
Query: 730 -------------------ETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQIL 770
++ K G LL+ E + +A+ KL + + + + D +L
Sbjct: 1205 GGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRD--VL 1262
Query: 771 QERMELLQQAHQRIRDLE--------DKTDIQKRQIKDLEEKS 805
+++++ L+ +R+ D E + D+Q++ ++ EEKS
Sbjct: 1263 RDQVQKLE---ERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS 1302
Score = 76.6 bits (187), Expect = 8e-14
Identities = 172/872 (19%), Positives = 333/872 (38%), Gaps = 161/872 (18%)
Query: 5 GRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR 64
GR G +P L++ L K +++ E H+ ++ +L K+Q EL+ R
Sbjct: 236 GRMDGREPAQLLLLL--------AKTQELEKEAHERSQELIQL---KSQGDLEKAELQDR 284
Query: 65 KHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDG 124
VTEL A L + + KQ+E + + +K ++ L++ L +
Sbjct: 285 -----VTELSALLTQSQ------------KQNE-DYEKMIKALRETVEILETNHTELMEH 326
Query: 125 SSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDL 184
+ R A E+L L Q I D+ + + D I G
Sbjct: 327 EASLSRNA-------------QEEKLSLQQVIKDITQVMVE---------EGDNIAQG-- 362
Query: 185 RSEHQSHQEAISKI-----KWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQL 239
S H++ E S I ++++ + + + + + + L ++L V LQ
Sbjct: 363 -SGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQ 421
Query: 240 QKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLE 299
Q + +E+ +++ ++ + + G+ D L + L
Sbjct: 422 QHDQWEEEGKALRQRLQKLTGERDTLAGQTVD-------------------LQGEVDSLS 462
Query: 300 DRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENS 359
LL R EL +++ E++ L N L + D + +E+L +E
Sbjct: 463 KERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERE 522
Query: 360 EMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVI--EQQNIIDELTRDREKLIRRR 417
++E + K+ +SL++L E E+ L+ +++ EQ + L R + +
Sbjct: 523 RLQEMLMGLEA-KQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581
Query: 418 KHRRSSKP---------IKRPVLDPFIGYDEDSM-------DSETSSMASFRTDRTPATP 461
+ K +K L+ + D+ + + E S+ S A
Sbjct: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641
Query: 462 DDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLR 521
+D + A + E + + T LQ+A E + D + E +E++Q ++
Sbjct: 642 ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE---KEEIQKKLSE 698
Query: 522 YKAKIEDLEATLAQKGQDS--------HWVEDKQLFIKRNQELLEKIEKQEAENHRLQQE 573
+ + E L Q Q++ V++K+ ++ L +++ E + L ++
Sbjct: 699 SRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQ 758
Query: 574 LQDARDQNELLEFRNLELEER----ERRSPPFNLQIHPFSDGVSALQ--IYCMK------ 621
LQ ELLE E +++ E +QI + +Q + C+K
Sbjct: 759 LQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTE 818
Query: 622 EGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKW-------IQQIEGAE 674
+ +QL G E+Q A V L EKW Q++ A
Sbjct: 819 RSQAEQERDAAARQLAQAEQEGKTALEQQKA-AHEKEVNQLREKWEKERSWHQQELAKAL 877
Query: 675 AALHQKMMELESDME----QFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQE 730
+L ++ MELE ++ + I+ EEE + AL Q + ++ +L L Q
Sbjct: 878 ESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQ- 936
Query: 731 TVIKFGELLSEKQQEELRTAVEKLRRQM-LRKSREYDC-----QILQERMELLQQAHQRI 784
++K+ + +E+LR+ M ++K +E + LQE L++A ++
Sbjct: 937 ---------TQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQH 987
Query: 785 RD------------LEDKTDIQKRQIKDLEEK 804
RD L+DK D+QK Q++DL+ +
Sbjct: 988 RDDLAALQEESSSLLQDKMDLQK-QVEDLKSQ 1018
Score = 70.5 bits (171), Expect = 6e-12
Identities = 138/724 (19%), Positives = 312/724 (43%), Gaps = 73/724 (10%)
Query: 86 QAVRENLIKQHEQEMSRTVKVRD---GEIQRLKSALCALRDGSSDKVRTALTIEAREEAR 142
+AV L K H Q++ +T + RD ++Q+L+ L D ++K + ++ +
Sbjct: 1239 EAVASALHKLH-QDLWKTQQTRDVLRDQVQKLEERLT---DTEAEKSQVHTELQDLQRQL 1294
Query: 143 KLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDL-RSEHQSHQEAISKIKWE 201
E+ K + L++ ++ E ++++ +++ +L R E Q +E + K
Sbjct: 1295 SQNQEEKSKWEGKQNSLESELMELHETMASL--QSRLRRAELQRMEAQGERELLQAAKEN 1352
Query: 202 SERDIRRLMD---EIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNM 258
+ L E +A+ LE++L T ++ + E+ E+ ++E
Sbjct: 1353 LTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQE----- 1407
Query: 259 SSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGDERN----ELLK 314
+ G+A + + L ++ + L I++LE + + +L K
Sbjct: 1408 QGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKK 1467
Query: 315 RVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEM-REKITSHPPLK- 372
R +E + Q + + E KC + + L +++Q E+KL ++ E+ +++ T L+
Sbjct: 1468 RNQEVDLQQEQIQELEKCRSVL-EHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEH 1526
Query: 373 KLKSLNDLDQANEEQ--ETEFLKLQVIEQQNIIDELTRD------REKLIRRRKHRRSSK 424
+L L DQ E Q + + LK Q++ + + EL + ++KLI+ + +R ++
Sbjct: 1527 QLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQ 1586
Query: 425 PIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPD-DDLDESLAAEESELRFRQLTK 483
+ L + + +++S + + T + + D+ + ++ ++ Q K
Sbjct: 1587 RVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQK 1646
Query: 484 EY--QALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSH 541
E+ Q L+R L ++ ER ++Q + + +E ++ +L ++G++
Sbjct: 1647 EHLTQDLERRDQEL------MLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGREL- 1699
Query: 542 WVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPF 601
+QL +R +E + Q ++ L RD+ + +E + + E +
Sbjct: 1700 -TTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL---RDKEKEVECQQEHIHELQELKDQL 1755
Query: 602 NLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLS 661
Q+ V + + ++ I L +QL + G L+ + +
Sbjct: 1756 EQQLQGLHRKVGETSLLLSQ---REQEIVVLQQQLQEAREQGELKEQSLQS--------- 1803
Query: 662 LAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLE---EELDYRKQALDQAYMRIQE 718
Q++ A+ AL Q+ ELE+ ++ + +G E E+ D + AL+QA+M ++E
Sbjct: 1804 -------QLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQ 778
L + +Q ++ EL E ++ + A+E++ + +SRE + +L + + +
Sbjct: 1857 RHGELQDHKEQARRLE-EELAVEGRRVQ---ALEEVLGDLRAESREQEKALLALQQQCAE 1912
Query: 779 QAHQ 782
QA +
Sbjct: 1913 QAQE 1916
Score = 60.1 bits (144), Expect = 8e-09
Identities = 98/442 (22%), Positives = 183/442 (41%), Gaps = 65/442 (14%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELE 62
++ + + E+ + ALQ A E L + EL K + +LE E E +R++ LE
Sbjct: 1827 QQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALE 1886
Query: 63 QRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALR 122
+ ++ +L+A+ E++ K L A+++ +Q ++ T ++D +Q A+ R
Sbjct: 1887 E-----VLGDLRAESREQE-KALLALQQQCAEQAQEHEVETRALQDSWLQ--AQAVLKER 1938
Query: 123 DGSSDKVRT-ALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKA 181
D + +R + + +EEA + R + LQE A Q E
Sbjct: 1939 DQELEALRAESQSSRHQEEAAR----ARAEALQEALGKAHAALQGKE------------- 1981
Query: 182 GDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYV--QKLQL 239
+H Q +S+ S ++ +D +A R LE+ L Q G + Q L+
Sbjct: 1982 -----QHLLEQAELSRSLEASTATLQASLDACQAHSR---QLEEALRIQEGEIQDQDLRY 2033
Query: 240 QKEALDEQLFLVKEAECNMSSPKRE------IPGRAGDGS-EHCSSPDLRRNQKRIAELN 292
Q++ Q L + E +RE + R + + + R ++ I L+
Sbjct: 2034 QEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLH 2093
Query: 293 ATIRKLEDRNTLLGDERNELLKRVRETEK-----------QCKPLLERNKCLAKRNDELM 341
++R+L+ L + E+L+ +RET++ + P+ E++ L L
Sbjct: 2094 QSVRELQ---LTLAQKEQEILE-LRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQ 2149
Query: 342 VSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVI---- 397
L+R++ L+ E REK L + ++ ++ FL+ V+
Sbjct: 2150 RELERLQAALRQTEAREIEWREKAQD---LALSLAQTKASVSSLQEVAMFLQASVLERDS 2206
Query: 398 EQQNIIDELTRDREKLIRRRKH 419
EQQ + DEL R L + R H
Sbjct: 2207 EQQRLQDELELTRRALEKERLH 2228
Score = 59.7 bits (143), Expect = 1e-08
Identities = 119/645 (18%), Positives = 274/645 (42%), Gaps = 96/645 (14%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR- 64
+ + E+ + A + + E ++ L D + E+ ++ + +L+ K Q ++++ L ++
Sbjct: 1707 QERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKV 1766
Query: 65 -KHTVLVTELKAKL-----HEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSAL 118
+ ++L+++ + ++ ++ +E ++E ++ E R + RD E++ L+
Sbjct: 1767 GETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQ 1826
Query: 119 CALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQ---EIADLKTAKKQVDEALS---N 172
+ G ++V+ E + + + + L + E+ D K ++++E L+
Sbjct: 1827 QQAQ-GQEERVK-----EKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGR 1880
Query: 173 MIQADKIKAGDLRSEHQSHQEAISKIKW-------ESERDIRRLMDE-------IKAKDR 218
+QA + GDLR+E + ++A+ ++ E E + R L D +K +D+
Sbjct: 1881 RVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQ 1940
Query: 219 IIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIP-----GRAGDGS 273
+ +L E ++ + + + EAL E L +A + ++ + R+ + S
Sbjct: 1941 ELEALRAESQSSRHQEEAARARAEALQEAL---GKAHAALQGKEQHLLEQAELSRSLEAS 1997
Query: 274 EHCSSPDLRRNQKRIAELNATIR----KLEDRNTLLGDERNELLKRVRETEKQCKPLLER 329
L Q +L +R +++D++ ++ +L + + + +++ + ER
Sbjct: 1998 TATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQER 2057
Query: 330 N----KCLAKRNDELMVS------LQRMEEKLKAVTKENSEMR----EKITSHPPLKKLK 375
K LA+R E M+ +R EE+++ + + E++ +K L++ +
Sbjct: 2058 EQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQ 2117
Query: 376 SLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKL---IRRRKHRRSSKPIKRPVLD 432
N+L+ +T ++ Q ++ ++ L R+ E+L +R+ + R K L
Sbjct: 2118 QRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLA 2177
Query: 433 PFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAY 492
+ + S+ SS+ + + D ++ +E EL R L KE
Sbjct: 2178 LSLAQTKASV----SSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERL------ 2227
Query: 493 ALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKR 552
G AE ++ ++ +Q ++ +EA + G + KQ + +R
Sbjct: 2228 ----HSPGATSTAELGSRGEQGVQL------GEVSGVEAEPSPDGME------KQSWRQR 2271
Query: 553 NQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERR 597
+ L + + + E + RLQ+ R LE ERERR
Sbjct: 2272 LEHLQQAVARLEIDRSRLQRHNVQLRS--------TLEQVERERR 2308
Score = 40.8 bits (94), Expect = 0.005
Identities = 133/632 (21%), Positives = 254/632 (40%), Gaps = 116/632 (18%)
Query: 235 QKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNAT 294
Q LQL E ++ L L ++ N ++ R++ + ++ + +R+ Q ++ + +
Sbjct: 14 QSLQLVLE--EQVLALQQQMAENQAASWRKL--KNSQEAQQRQATLVRKLQAKVLQYRSW 69
Query: 295 IRKLEDRNTLLG----------DERN--ELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
++LE R G +E N ELL R+ E +++C+ L E N L ++ V
Sbjct: 70 CQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADV 129
Query: 343 SLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNI 402
+ + E ++ +T + S R+++ ++K ++ + E EF K + +
Sbjct: 130 VNKALREDVEKLTVDWSRARDEL-----MRK--------ESQWQMEQEFFKGYLKGEHGR 176
Query: 403 IDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPD 462
+ L R+ ++ R+H L+ D D M+ + + R + T
Sbjct: 177 LLSLWRE---VVTFRRH----------FLEMKSATDRDLMELKAEHV---RLSGSLLTCC 220
Query: 463 DDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQE--QLQAEVL 520
L + E R +E L A QE ++ E ++QE QL+++
Sbjct: 221 LRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQE-----LEKEAHERSQELIQLKSQGD 275
Query: 521 RYKAKIED----LEATLAQKGQDSHWVEDKQLFIKRNQELLEKIE--------------- 561
KA+++D L A L Q + + ED + IK +E +E +E
Sbjct: 276 LEKAELQDRVTELSALLTQSQKQN---EDYEKMIKALRETVEILETNHTELMEHEASLSR 332
Query: 562 KQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQI---HPFSDGVSALQIY 618
+ E LQQ ++D Q + E N+ S + I + D AL +
Sbjct: 333 NAQEEKLSLQQVIKDI-TQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDADKALTLV 391
Query: 619 CMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALH 678
+ + DL +QL + NL ++ + L + +Q++ G L
Sbjct: 392 RSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKAL---RQRLQKLTGERDTLA 448
Query: 679 QKMMELESDMEQFCKIKGYLE---EELDYRKQALDQAYMRIQELEATLYNALQQETVIKF 735
+ ++L+ +++ K + L+ EEL + + L+Q R++ + L LQ ++
Sbjct: 449 GQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVEL--QLQGDS---- 502
Query: 736 GELLSEKQQEELRTAV---EKLR--------------------RQMLRKSREYDCQILQE 772
+ E+QQEEL AV E+L+ R+ L S + QE
Sbjct: 503 AQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQE 562
Query: 773 RMEL---LQQAHQRIRDLEDKTDIQKRQIKDL 801
+ E+ L +A Q I +L + K ++ DL
Sbjct: 563 QTEVTAALARAEQSIAELSSSENTLKTEVADL 594
Score = 38.5 bits (88), Expect = 0.025
Identities = 59/279 (21%), Positives = 126/279 (45%), Gaps = 40/279 (14%)
Query: 556 LLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSAL 615
LL K ++ E E H QEL + Q +L EL++R Q ++ +
Sbjct: 249 LLAKTQELEKEAHERSQELIQLKSQGDL---EKAELQDRVTELSALLTQSQKQNEDYEKM 305
Query: 616 QIYCMKEGVK--DVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEG- 672
I ++E V+ + N +L++ L N EE++++ Q + + + +++ +
Sbjct: 306 -IKALRETVEILETNHTELMEHEASLSRNA---QEEKLSLQQ--VIKDITQVMVEEGDNI 359
Query: 673 AEAALHQKMMELES------DMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNA 726
A+ + H+ +EL+S D + K + L R+QA+ ++ + + N
Sbjct: 360 AQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV-NL 418
Query: 727 LQQ--ETVIKFGELLSEKQQE-------------ELRTAVEKL--RRQMLRKSREYDCQI 769
LQQ + + G+ L ++ Q+ +L+ V+ L R++L+K+RE
Sbjct: 419 LQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREE---- 474
Query: 770 LQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSNRK 808
L++++E+L+Q R+R + + +Q + +E+ +
Sbjct: 475 LRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEE 513
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 101 bits (252), Expect = 2e-21
Identities = 179/836 (21%), Positives = 340/836 (40%), Gaps = 107/836 (12%)
Query: 24 EDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQ---------RKHTVLVTELK 74
E+LR K + + LH+ + L+ EK+Q ++I +L + R+ + +L+
Sbjct: 279 EELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQ 338
Query: 75 AKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRD------------GEIQRLKSALCALR 122
L+E + +A +E L KQ + E + ++D G++ +L+ L L+
Sbjct: 339 DALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQ 398
Query: 123 DG----SSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEAL---SNMIQ 175
D + + L +E ++ +L + L+T + Q + L +
Sbjct: 399 DNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFE 458
Query: 176 ADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQ 235
+K + L ++ QS +S+ K E E+ + + A+ + SL EL T +Q
Sbjct: 459 EEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQ---VASLTSELTTLNATIQ 515
Query: 236 KLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEH------CSSPDLRRNQKRIA 289
+ + L +Q KE + ++ ++ +A G H S + K +A
Sbjct: 516 QQDQELAGLKQQ---AKEKQAQLAQTLQQ-QEQASQGLRHQVEQLSSSLKQKEQQLKEVA 571
Query: 290 ELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKC--LAKRNDELMVSLQRM 347
E R+ + E E R R+ + LE+ K L +L V+ +
Sbjct: 572 EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEAR 631
Query: 348 EEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDE-- 405
+ +VT+ E E L+ +Q + + L+LQ+ +Q E
Sbjct: 632 DSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKE 691
Query: 406 -LTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPD-- 462
+ +++++L + + + S + + L+ D+++ + ++ + +
Sbjct: 692 RVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK 751
Query: 463 ---DDLDESLAAEES-ELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQ-EQLQA 517
+L+E A + E R +QL + +QA +L+ + + A+ A+++ EQL
Sbjct: 752 RERKELEEERAGRKGLEARLQQLGEAHQA---ETEVLRRELAEAMAAQHTAESECEQLVK 808
Query: 518 EVLRYKAKIEDLEATLAQKGQ--DSHWVEDKQLFIKRNQELLEKIEKQEA-ENHRLQQEL 574
EV ++ + ED + AQ G + K+ K QEL E EK E+H EL
Sbjct: 809 EVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESH---SEL 865
Query: 575 QDARDQNELLEFR-NL-----ELEERERRSPPFNLQIHPFSDGVSA-------LQIYCMK 621
Q +R QNEL E NL +++E+E R+ + + ++A L+ K
Sbjct: 866 QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRK 925
Query: 622 EG-VKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSL------AEKWIQQIEGAE 674
G ++ +L+K+ GD EEQ ST +L AE+ ++E
Sbjct: 926 AGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLR 985
Query: 675 AAL-------HQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQEL-------E 720
AAL ++ + E ++ + + +G + +L K A + MR+Q
Sbjct: 986 AALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEF 1045
Query: 721 ATLYNALQQETVIKFG-----------ELLSEKQQEELRTAVEKLRRQMLRKSREY 765
ATL AL K G E K+ EELR V++L+ Q+ +K +E+
Sbjct: 1046 ATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
Score = 83.6 bits (205), Expect = 7e-16
Identities = 193/932 (20%), Positives = 362/932 (38%), Gaps = 157/932 (16%)
Query: 8 KGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHT 67
K E+ +A + + + + ++ +++++L E+ K ++ ER ++ + +L+ K +
Sbjct: 651 KVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKES 710
Query: 68 VLVTELKAKLHEEKMK-------------ELQAVRENLIKQHEQEMSRTVKVRDGEIQRL 114
+ VT K L EEK + EL+A +L++QH++E + R G + L
Sbjct: 711 LKVT--KGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGR-KGL 767
Query: 115 KSALCALRDGSSDKVRTALTIEAREEA---RKLFDTERLKLLQEIA-------DLKTAKK 164
++ L L G + + T + EA + ++E +L++E+A D + +
Sbjct: 768 EARLQQL--GEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEA 825
Query: 165 QVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLE 224
Q + K + R E Q +E ++ I+ SE I R +E+ +
Sbjct: 826 QYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARAL 885
Query: 225 KELETQTGYVQKLQLQKEALDEQLF-----------LVKEAECNMSSPKREI---PGRAG 270
++++ + QKL L E++ LV++A + RE+ P RAG
Sbjct: 886 QQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAG 945
Query: 271 D----------GSEHCSSPDLRRNQKRIAE--------LNATIRKLE-DRNTLLGDERNE 311
D G + CS+ + +R AE L A + + + + G + E
Sbjct: 946 DRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQERE 1005
Query: 312 LLKRVRET---------EKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMR 362
+ + +E EK + LE L +E V ++E L E
Sbjct: 1006 VARLTQERGRAQADLALEKAARAELEMR--LQNALNEQRVEFATLQEALAHALTEKEGKD 1063
Query: 363 EKITSHPPLK--KLKSLNDLDQ---------ANEEQE----------------------- 388
+++ L+ ++K L +L Q A +E+E
Sbjct: 1064 QELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLE 1123
Query: 389 -----TEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPF---IGYDED 440
L+ Q +QQ D L R E R R S+ + L+ +G+ +
Sbjct: 1124 ALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQS 1183
Query: 441 SMDSETSSMASFRT---DRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQE 497
++ S +A+FRT D + A + + +E+E + ++ +L+ ++L
Sbjct: 1184 ALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS----SLEEEVSILNR 1239
Query: 498 QTGGIIDAEREAKAQEQLQAEVLRYKAKIED-LEATLAQKGQDSHWVEDKQLFIKRN-QE 555
Q +++ E E+K ++L K+E+ L A+ +S ++ ++ Q
Sbjct: 1240 Q---VLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQS 1296
Query: 556 LLEKIEKQEAENHRLQQELQDARDQNELL--EFRNLELEERERRSPPFNLQIHPFSDGVS 613
L E+ EKQ + L+QEL ++ E L E + + + ++ LQ+ S
Sbjct: 1297 LREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQAL 1356
Query: 614 ALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIE-G 672
++ K L +QL R+ E++ + + AE Q E G
Sbjct: 1357 VSELLPAKH---------LCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELG 1407
Query: 673 AEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQAL-----------DQAYMRIQELEA 721
L QK+ E E +Q K E+L K+A ++A + Q LE
Sbjct: 1408 ELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEV 1467
Query: 722 TLYNALQ---QETVIKFGEL---LSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERME 775
L A + QE + L+E Q+E TA E M K ++L+ER
Sbjct: 1468 ELDQAREKYVQELAAVRADAETRLAEVQREAQSTAREL--EVMTAKYEGAKVKVLEERQR 1525
Query: 776 LLQQAHQRIRDLEDKTDIQKRQIKDLEEKSNR 807
++ + +E Q+ Q K +EE S +
Sbjct: 1526 FQEERQKLTAQVEQLEVFQREQTKQVEELSKK 1557
Score = 81.3 bits (199), Expect = 3e-15
Identities = 166/808 (20%), Positives = 332/808 (41%), Gaps = 119/808 (14%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRK 65
+ K K E L LQ ANE + T + + +EK+++S+ + E+ Q EQ +
Sbjct: 611 KEKAAKLEILQQQLQVANEARDSAQTSV-TQAQREKAELSR-KVEELQACVETARQEQHE 668
Query: 66 HTVLVTELKAKLHEEKM----KELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCAL 121
V EL+ +L E+ KE A ++ +++ Q + ++KV G ++ K
Sbjct: 669 AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKR----- 723
Query: 122 RDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKA 181
R + + + E + E R L + + + +E+ + + +K ++ L + +A + +
Sbjct: 724 RAADALEEQQRCISELKAETRSLVEQHK-RERKELEEERAGRKGLEARLQQLGEAHQAET 782
Query: 182 GDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQK 241
LR E A + +E + +L+ E+ A R + ++ E Q G +
Sbjct: 783 EVLRRELAEAMAA----QHTAESECEQLVKEVAAW-RERYEDSQQEEAQYGAM------- 830
Query: 242 EALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDR 301
EQL +KE EC + + + G E S + R Q +AEL+A + +
Sbjct: 831 --FQEQLMTLKE-ECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLAR---- 883
Query: 302 NTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEM 361
L++V+E E + + L + L E M + + +L+ + ++ E
Sbjct: 884 ----------ALQQVQEKEVRAQKLADDLSTL----QEKMAATSKEVARLETLVRKAGEQ 929
Query: 362 REKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRR 421
+E + + ++ + + EEQ+ Q Q + + R+ E++ + R
Sbjct: 930 QETASRELVKEPARAGDRQPEWLEEQQGR----QFCSTQAALQAMEREAEQMGNELERLR 985
Query: 422 SSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQL 481
++ L G ++ + +A +R A D L E A E E+R +
Sbjct: 986 AA-------LMESQGQQQEERGQQEREVARLTQERGRAQADLAL-EKAARAELEMRLQNA 1037
Query: 482 TKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSH 541
E + +A LQE + E+E K QE AK+ LEA ++
Sbjct: 1038 LNEQRV---EFATLQEALAHAL-TEKEGKDQE---------LAKLRGLEAAQIKE----- 1079
Query: 542 WVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPF 601
+E+ + +K+ +E L K EK+ A Q E R+ P
Sbjct: 1080 -LEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG--------------------RTEPT 1118
Query: 602 NLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLS 661
++ VS L+ C K+ L + L+ R E A+ T+
Sbjct: 1119 GPKLEALRAEVSKLEQQCQKQ---QEQADSLERSLEA---ERASRAERDSAL---ETLQG 1169
Query: 662 LAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEA 721
E+ Q++ +++AL EL + K++ + + E +++ Q + E +
Sbjct: 1170 QLEEKAQELGHSQSALASAQRELAAFR---TKVQDHSKAEDEWKAQV--ARGRQEAERKN 1224
Query: 722 TLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQ-QA 780
+L ++L++E I ++L EK+ E ++L+R ++ +S + Q L+ER+ LLQ +
Sbjct: 1225 SLISSLEEEVSILNRQVL-EKEGES-----KELKRLVMAESEK--SQKLEERLRLLQAET 1276
Query: 781 HQRIRDLEDKTDIQKRQIKDLEEKSNRK 808
+++ + +++ L E++ ++
Sbjct: 1277 ASNSARAAERSSALREEVQSLREEAEKQ 1304
Score = 70.5 bits (171), Expect = 6e-12
Identities = 135/669 (20%), Positives = 280/669 (41%), Gaps = 120/669 (17%)
Query: 159 LKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDR 218
++ KKQ+ + SN R E + K+ E + I + I DR
Sbjct: 216 MRRLKKQLADERSN------------RDELELELAENRKLLTEKDAQIAMMQQRI---DR 260
Query: 219 IIFSLEKELET--QTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHC 276
+ EK+ + + +++L+ + E+L +L + ++ + K ++ + SE
Sbjct: 261 LALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEE- 319
Query: 277 SSPDLRRNQKRIAELNATIRKLEDRNTLLGDERN----ELLKRVRETEKQCKPLLERNKC 332
+ DL ++ E + +++L+D L +E + E L++ + EK+ L+ KC
Sbjct: 320 -NGDL---SFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC 375
Query: 333 LAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANE-EQETEF 391
L ++N+ L L ++EE L ++ +PP +K + L D+ Q +QE
Sbjct: 376 LEEKNEILQGKLSQLEEHL-----------SQLQDNPPQEKGEVLGDVLQLETLKQEAAT 424
Query: 392 LKLQVIEQQNIIDELTRDR----EKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETS 447
L + Q ++ L +R KL+ R H K ++ + S S
Sbjct: 425 LAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLI--------TDLQSSIS 476
Query: 448 SMASFRTDRTPATPDDDLDESLAAEESEL--RFRQLTKEYQALQRAYALLQEQTGGIIDA 505
+++ + ++L+++ A + L + LT E L A +Q+Q +
Sbjct: 477 NLSQAK---------EELEQASQAHGARLTAQVASLTSELTTLN---ATIQQQDQELAGL 524
Query: 506 EREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIK-RNQELLEKIEKQE 564
+++AK ++ A+ L+ + + A +G H VE +K + Q+L E EKQE
Sbjct: 525 KQQAKEKQAQLAQTLQQQEQ--------ASQGL-RHQVEQLSSSLKQKEQQLKEVAEKQE 575
Query: 565 AENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGV 624
A Q+L A ++ R L ER+ +AL+ E
Sbjct: 576 ATRQDHAQQLATAAEE------REASLRERD-----------------AALKQLEALEKE 612
Query: 625 KDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMEL 684
K + L +QL + + R+ Q ++ QA + + +++++ Q+ E
Sbjct: 613 KAAKLEILQQQLQVANE---ARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEA 669
Query: 685 ESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQ------QETVIKFGEL 738
++ + + +++ E++ K+ + Q ++QE L +L+ +E + +
Sbjct: 670 QAQVAEL-ELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADA 728
Query: 739 LSEKQQ--EELRTAVEKLRRQMLRKSREYDCQI-----LQERMELLQQAHQRIRDLEDKT 791
L E+Q+ EL+ L Q R+ +E + + L+ R++ L +AHQ +T
Sbjct: 729 LEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA------ET 782
Query: 792 DIQKRQIKD 800
++ +R++ +
Sbjct: 783 EVLRRELAE 791
Score = 66.6 bits (161), Expect = 9e-11
Identities = 185/871 (21%), Positives = 350/871 (40%), Gaps = 124/871 (14%)
Query: 1 MSKKGRNKGEKPEALIVALQAANE-DLRT-KLTDIQIELHQEKSKVSK-LEREKTQEAKR 57
+S++ E L ALQ E ++R KL D L ++ + SK + R +T K
Sbjct: 867 ISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKA 926
Query: 58 IRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHE-QEMSRTVKVRDGEIQRLKS 116
+ E ++ +A + + E Q R+ Q Q M R + E++RL++
Sbjct: 927 GEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA 986
Query: 117 ALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQA 176
AL + G + R + RE AR ER + ++A K A+ +++ L N +
Sbjct: 987 ALMESQ-GQQQEERGQ---QEREVAR--LTQERGRAQADLALEKAARAELEMRLQNALNE 1040
Query: 177 DKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQK 236
+++ L QEA++ E E KD+ + L Q +++
Sbjct: 1041 QRVEFATL-------QEALAHALTEKE-----------GKDQELAKLRGLEAAQIKELEE 1082
Query: 237 LQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIR 296
L+ + L EQL ++ + S + E GR + P L + +++L +
Sbjct: 1083 LRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP-----TGPKLEALRAEVSKLEQQCQ 1137
Query: 297 KLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRM---EEKLKA 353
K + E+ + L+R E E+ + ER+ L +L Q + + L +
Sbjct: 1138 KQQ--------EQADSLERSLEAERASRA--ERDSALETLQGQLEEKAQELGHSQSALAS 1187
Query: 354 VTKENSEMREKITSHPPLKK------LKSLNDLDQANE-----EQETEFLKLQVIEQQNI 402
+E + R K+ H + + + ++ N E+E L QV+E++
Sbjct: 1188 AQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGE 1247
Query: 403 IDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPD 462
EL R + + +S K +R L + +ET+S ++ +R+ A +
Sbjct: 1248 SKELKR-----LVMAESEKSQKLEERLRL----------LQAETASNSARAAERSSALRE 1292
Query: 463 DDLDESLAAEESELRFRQLTKEYQA-LQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLR 521
+ AE+ + L +E + +RA L QE ++ +A LQ E
Sbjct: 1293 EVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTS 1352
Query: 522 YKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQN 581
+A + +L L K ++ KR++E LE+ KQ A R + L+ R+
Sbjct: 1353 TQALVSEL---LPAKHLCQQLQAEQAAAEKRHREELEQ-SKQAAGGLRAEL-LRAQRELG 1407
Query: 582 ELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQI---YCMKEGVKDVNIPDLIKQ-LD 637
EL+ R ++ E+ER + + +++ +S L+ +E +L +Q L+
Sbjct: 1408 ELIPLRQ-KVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLE 1466
Query: 638 ILGDNGNLRNEEQVAIIQASTVLSLAEKWIQ-------------QIEGAEAAL------- 677
+ D + +++A ++A LAE + + EGA+ +
Sbjct: 1467 VELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRF 1526
Query: 678 ---HQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAY-MRIQELEATLYNALQ----- 728
QK+ +E F + + EEL + DQA ++ Q+L+A +
Sbjct: 1527 QEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEA 1586
Query: 729 QETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDC-----QILQERMELLQQAHQR 783
Q + EL ++ Q+E A E + QM + YD Q LQE++ L+Q +
Sbjct: 1587 QRLQAQLNELQAQLSQKE--QAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKE 1644
Query: 784 IRDLEDKT-----DIQKRQIKDLEEKSNRKH 809
++L + ++Q+ +K E + +H
Sbjct: 1645 NKELRAEAERLGHELQQAGLKTKEAEQTCRH 1675
Score = 32.3 bits (72), Expect = 1.8
Identities = 57/257 (22%), Positives = 102/257 (39%), Gaps = 36/257 (14%)
Query: 551 KRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSD 610
K QE LEK + E E Q+ + ++NE+L+ + +LEE
Sbjct: 350 KATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEH---------------- 393
Query: 611 GVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQAS--TVLSLAEKWIQ 668
+S LQ N P ++ ++LGD L +Q A A+ T L + ++
Sbjct: 394 -LSQLQD----------NPPQ--EKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLE 440
Query: 669 QIEGA-EAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNAL 727
G EA L + E + +Q + L+ + QA ++ Q A L A
Sbjct: 441 TERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARL-TAQ 499
Query: 728 QQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDL 787
+ L + QQ++ A K Q ++ + Q LQ++ + Q ++ L
Sbjct: 500 VASLTSELTTLNATIQQQDQELAGLK---QQAKEKQAQLAQTLQQQEQASQGLRHQVEQL 556
Query: 788 EDKTDIQKRQIKDLEEK 804
+++Q+K++ EK
Sbjct: 557 SSSLKQKEQQLKEVAEK 573
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 101 bits (252), Expect = 2e-21
Identities = 183/849 (21%), Positives = 388/849 (45%), Gaps = 100/849 (11%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQ-IELHQEKSKVSKLER----EKTQEAKRI-- 58
R + EK E +AA E+L L+ Q E + K K E+ EKT E +RI
Sbjct: 402 REQKEKSE------RAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISL 455
Query: 59 -RELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRL--- 114
+EL + K V+ ++ K EE++ +LQ + E + + EQE+++ ++ R+ E Q
Sbjct: 456 QQELSRVKQEVV--DVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKV 513
Query: 115 ---KSALCALRDGSSDKVRTALTIEAREEARKLFDTE---RLKLLQEIAD-LKTAKKQVD 167
KS L+ + + +L +E E +K TE +L+ LQ+ A+ +T +++
Sbjct: 514 ALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELE 573
Query: 168 EALSNMIQADKIKAGD----LRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSL 223
+L +Q +K ++ D L +E H + I+ + + + + ++ +K + +++
Sbjct: 574 SSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE----LESLKHQQDALWTE 629
Query: 224 EKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRR 283
+ ++ Q + +L+++ E+ L+K+ E + E+ + + + +L
Sbjct: 630 KLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLD-VKQTELES 688
Query: 284 NQKRIAELNATIRKLEDRNTLLGDERNELLKRVR-ETEKQCKPLLERNKCLAKRNDELMV 342
++E+ KLE+ ++L D+ +++ + + + ++Q ++ + K ++ V
Sbjct: 689 LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE---V 745
Query: 343 SLQRMEEKLK-------AVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQ 395
S+QR E+ LK + KE + ++ +H ++ L++ D+ ++ E + KL
Sbjct: 746 SIQRTEKALKDQINQLELLLKERDKHLKEHQAH--VENLEA--DIKRSEGELQQASAKLD 801
Query: 396 VIEQ-QNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRT 454
V + Q+ E T+ E+ + + + + +R +L + E + + + +
Sbjct: 802 VFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKI 861
Query: 455 DRTPATPDDDLDESLAAEESEL--RFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQ 512
DL + L + SE+ + + LT+ Y++ QEQT I+ E+E
Sbjct: 862 Q------VQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQIL-VEKENMIL 914
Query: 513 EQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQ 572
+ + + K +IE L L+ K H + ++ +NQE +K+EK + + +Q+
Sbjct: 915 QMREGQ----KKEIEILTQKLSAKEDSIHILNEEYETKFKNQE--KKMEKVKQKAKEMQE 968
Query: 573 EL------QDARDQNELLEFRNLELEERERRSPPFNLQIHP-----FSDGVSALQIYCMK 621
L Q+A+ + E LE LEL ++E++ L++ SD VS L+ K
Sbjct: 969 TLKKKLLDQEAKLKKE-LENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETN-QK 1026
Query: 622 EGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKM 681
E ++ + + D++ N+ QA + + E +Q+ E A L QK+
Sbjct: 1027 EQIESLTEVHRRELNDVISIWEKKLNQ------QAEELQEIHEIQLQEKEQEVAELKQKI 1080
Query: 682 MELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSE 741
+ + E+ K +L+EE + L++ ++++ A + + Q ET +K
Sbjct: 1081 LLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLK------- 1133
Query: 742 KQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDK---TDIQKRQI 798
E+L + K L+++ Q+++ +M L ++ +++ +L K TD + + +
Sbjct: 1134 AHLEKLEVDLNK----SLKENTFLQEQLVELKM-LAEEDKRKVSELTSKLKTTDEEFQSL 1188
Query: 799 KDLEEKSNR 807
K EKSN+
Sbjct: 1189 KSSHEKSNK 1197
Score = 89.7 bits (221), Expect = 1e-17
Identities = 186/853 (21%), Positives = 364/853 (42%), Gaps = 167/853 (19%)
Query: 13 EALIVALQAANEDLRTKLTDIQIELHQE-----KSKVSKLER-----EKTQEAKRIRELE 62
EA I +L+ ++ + +L D +L + K K+S LE+ K E K+ +
Sbjct: 1393 EAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSR 1452
Query: 63 QRKHTVLVTELKAKLHEEKMKELQAVRE--NLIKQHEQEMSRTVKVRDGEIQRLKSALCA 120
+H V EL+ +L E K KE E NL+K+ + ++ GE++ KS +
Sbjct: 1453 FTQHQNTVKELQIQL-ELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM-- 1509
Query: 121 LRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIK 180
+K + L E + + ++ + E + Q+ ++++ ++E L N Q I+
Sbjct: 1510 ------EKKESNLETELKSQTARIMELED-HITQKTIEIES----LNEVLKNYNQQKDIE 1558
Query: 181 AGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ 240
+L + Q QE + E + ++ ++I + ++S++ ELET+ ++ + L
Sbjct: 1559 HKELVQKLQHFQE----LGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLS 1614
Query: 241 KEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLED 300
++ +E+L K E + S + ++AEL RK E
Sbjct: 1615 VKSKEEEL---KALEDRLES----------------------ESAAKLAELK---RKAEQ 1646
Query: 301 RNTLLGDERNELLKRVRETEKQCKP-----LLERNKCLAKRNDELMVSLQRMEEKLKAVT 355
+ + + +LL ++ E E+Q K L E N L +R E+ + +EEKLK+V
Sbjct: 1647 KIAAI---KKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHI----LEEKLKSVE 1699
Query: 356 KENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIR 415
SE S + + D Q+T K+ V+ Q+N+ ++EKL++
Sbjct: 1700 SSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVL-QRNL-----TEKEKLLQ 1753
Query: 416 RRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESE 475
R +G +++ S M +R + + E +
Sbjct: 1754 R------------------VGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQ----HEDQ 1791
Query: 476 LRFRQLTKEYQALQRAYALL----QEQTGG------------IIDAEREAKAQEQLQAEV 519
L +E + + Y+L+ E+ GG + D ++ +++L ++
Sbjct: 1792 SMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQI 1851
Query: 520 LRYKAKIEDLEATLAQKGQDSHWVEDKQLFIK------------RNQ--ELLEKIEKQEA 565
L + KI++L++ L ++ ++ H VE ++L K RN+ ELLE+ ++++
Sbjct: 1852 L--EQKIKELDSCLVRQ-KEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKS 1908
Query: 566 ENHRLQQE-LQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGV 624
++H +Q + L + Q+ LEF+ L ER +I + L+ KE
Sbjct: 1909 KSHLVQPKLLSNMEAQHNDLEFK---LAGAEREKQKLGKEIVRLQKDLRMLR----KEHQ 1961
Query: 625 KDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMEL 684
+++ I L K+ D + + +E + + ST+ L ++ Q L QK EL
Sbjct: 1962 QELEI--LKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQ-------LAQKEQEL 2012
Query: 685 ESDMEQFCKIKGYLEEE-LDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQ 743
E +++ +E E L+ ++ +Q +I E + L + T ++ E+L + +
Sbjct: 2013 EMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDL-----KRTAKRYEEIL-DAR 2066
Query: 744 QEELRTAVEKLRRQMLRKSREYDCQILQER---------MELLQQAHQR---IRDLEDKT 791
+EE+ V L+ Q+ ++Y ++ QE MEL Q Q+ I D + K
Sbjct: 2067 EEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKE 2126
Query: 792 DIQKRQIKDLEEK 804
+ QI +LE++
Sbjct: 2127 QEFREQIHNLEDR 2139
Score = 76.6 bits (187), Expect = 8e-14
Identities = 175/900 (19%), Positives = 367/900 (40%), Gaps = 141/900 (15%)
Query: 1 MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSK----------------- 43
M K + E E L L L+ +L + +EL Q++ +
Sbjct: 956 MEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGIS 1015
Query: 44 --VSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMS 101
VS+LE + ++ + + E+ +R+ +++ + KL+++ +ELQ + E +++ EQE++
Sbjct: 1016 DAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQA-EELQEIHEIQLQEKEQEVA 1074
Query: 102 ---RTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIAD 158
+ + + E + + + L++ + V+ T+ +E K L Q+
Sbjct: 1075 ELKQKILLFGCEKEEMNKEITWLKE---EGVKQDTTLNELQEQLKQKSAHVNSLAQDETK 1131
Query: 159 LKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRR---LMDEIKA 215
LK ++++ L+ ++ E+ QE + ++K +E D R+ L ++K
Sbjct: 1132 LKAHLEKLEVDLNKSLK-----------ENTFLQEQLVELKMLAEEDKRKVSELTSKLKT 1180
Query: 216 KDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFL-----VKEAECNMSSPKREIPGRAG 270
D SL+ E ++ L+ + L E+L + K+ E + + E+ +
Sbjct: 1181 TDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISS 1240
Query: 271 DGSE-------HCSSPDLRRNQK------RIAELNATIRKLEDRNTLLGDERNELLKRVR 317
+ HC + + ++EL A +R+L + L + ++
Sbjct: 1241 SKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLE 1300
Query: 318 ETEKQCKPLLERNKCL-----------------AKRNDELMVSLQR-MEEKLKAVTKENS 359
E E Q K + + L A + + L++ + E + AVT
Sbjct: 1301 EKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKE 1360
Query: 360 EMREKITSHPPLKK------LKSLNDLDQANEEQETEFLKLQVIEQQ-NIIDELTRDREK 412
E++EK L K ++ N + + +E L+ Q E++ ++D++ K
Sbjct: 1361 ELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFK 1420
Query: 413 LIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASF-RTDRTPATPDDDLD-ESLA 470
+ K + S+ L+ + + + + + F + T L+ +S
Sbjct: 1421 VDTLSKEKISA-------LEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKE 1473
Query: 471 AEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLE 530
A E + + L +E + + L+ + D + K + L+ E+ A+I +LE
Sbjct: 1474 AYEKDEQINLLKEELDQQNKRFDCLKGEMED--DKSKMEKKESNLETELKSQTARIMELE 1531
Query: 531 ATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLE 590
+ QK +E + L N+ L ++++ E+ L Q+LQ + EL E ++
Sbjct: 1532 DHITQK-----TIEIESL----NEVLKNYNQQKDIEHKELVQKLQHFQ---ELGEEKDNR 1579
Query: 591 LEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRN--- 647
++E E + Q++ ++ K+ ++ VN+ K+ ++ L +
Sbjct: 1580 VKEAEEKILTLENQVYSMK-----AELETKKKELEHVNLSVKSKEEELKALEDRLESESA 1634
Query: 648 ----------EEQVAIIQASTVLSLAEKWIQQIEGAE---AALHQKMMELESDM----EQ 690
E+++A I+ + + EK Q +G E + L+ K+ E E ++ E+
Sbjct: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEK 1694
Query: 691 FCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQ---QETVIKFGELLSEKQQEEL 747
++ E L + A + A QE EA +Q +E + L+EK E+L
Sbjct: 1695 LKSVESSQSETLIVPRSAKNVAAYTEQE-EADSQGCVQKTYEEKISVLQRNLTEK--EKL 1751
Query: 748 RTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSNR 807
V + + + + E CQ QER L++ H + ED++ I Q ++LEEK+ +
Sbjct: 1752 LQRVGQEKEETVSSHFEMRCQ-YQER--LIKLEHAEAKQHEDQSMIGHLQ-EELEEKNKK 1807
Score = 72.4 bits (176), Expect = 2e-12
Identities = 172/827 (20%), Positives = 351/827 (42%), Gaps = 154/827 (18%)
Query: 30 LTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTV------LVTELKAKLHEEKMK 83
+++++ +L Q + + L Q ++ E E + ++ LVTE +A L +E
Sbjct: 1271 VSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEA-LQKEGGN 1329
Query: 84 ELQAV--RENLIKQHEQEMSRTVK---VRDGEIQRLKSALCALRDGSSD---KVRTALTI 135
+ QA +E+ I Q ++E+S + + E++ K + +L +D +++ ++++
Sbjct: 1330 QQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISL 1389
Query: 136 EAREEA----RKLFDTERLKLLQEIADLK-----------TAKKQVDEALSNMIQADKIK 180
+E A RK +D E+ +LL ++ DL +A +QVD+ SN K K
Sbjct: 1390 SEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDD-WSNKFSEWKKK 1448
Query: 181 AGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ 240
A +S HQ + +++ + E + E KD I L++EL+ Q ++
Sbjct: 1449 A---QSRFTQHQNTVKELQIQLELKSK----EAYEKDEQINLLKEELDQQN---KRFDCL 1498
Query: 241 KEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLED 300
K +++ +++ E N+ + +L+ RI EL I +
Sbjct: 1499 KGEMEDDKSKMEKKESNLET-------------------ELKSQTARIMELEDHITQ--- 1536
Query: 301 RNTLLGDERNELLKRVRETEK-QCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENS 359
T+ + NE+LK + + + K L+++ + + +E ++ EEK+ +T EN
Sbjct: 1537 -KTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKI--LTLENQ 1593
Query: 360 EMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKH 419
K K+L+ +N ++ EE+ L+ +E + + + E +RK
Sbjct: 1594 VYSMKAELETKKKELEHVNLSVKSKEEE------LKALEDRLESESAAKLAEL---KRKA 1644
Query: 420 RRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFR 479
+ IK+ +L EE E +++
Sbjct: 1645 EQKIAAIKKQLLSQM-------------------------------------EEKEEQYK 1667
Query: 480 QLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQD 539
+ T+ + L LQE+ + E + K+ E Q+E L +++ A Q+ D
Sbjct: 1668 KGTESH--LSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEAD 1725
Query: 540 SHWV-----EDKQLFIKRN----QELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLE 590
S E+K ++RN ++LL+++ +++ E E++ + Q L++ + E
Sbjct: 1726 SQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMR-CQYQERLIKLEHAE 1784
Query: 591 LEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQ 650
++ E +S +LQ ++E K ++ + + ++ G N++ ++
Sbjct: 1785 AKQHEDQSMIGHLQEE-------------LEEKNKKYSLI-VAQHVEKEGGKNNIQAKQN 1830
Query: 651 VAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELD--YRK-Q 707
+ V +K +Q+ E L QK+ EL+S + + ++ EEL Y K Q
Sbjct: 1831 L-----ENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQ 1885
Query: 708 ALDQAYMRIQELEATLYNALQQ-ETVIKFGELLS--EKQQEELRTAVEKLRRQMLRKSRE 764
AL Q R + E N ++ ++ + +LLS E Q +L + R+ + +E
Sbjct: 1886 ALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKE 1945
Query: 765 YDCQILQERMELLQQAHQRIRDLEDKTDIQKRQ--IKDLEEKSNRKH 809
LQ+ + +L++ HQ+ ++ K Q+R+ IK +E KH
Sbjct: 1946 I--VRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKH 1990
Score = 69.7 bits (169), Expect = 1e-11
Identities = 152/768 (19%), Positives = 318/768 (41%), Gaps = 160/768 (20%)
Query: 51 KTQEAKRIRELEQR------KHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTV 104
K Q +R+R +E+ K++ LVT + L EK K+LQ + L + ++ + R
Sbjct: 136 KEQLIQRLRRMERSLSSYRGKYSELVTAYQM-LQREK-KKLQGI---LSQSQDKSLRRIA 190
Query: 105 KVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKK 164
++R+ E+Q + A L++ ++E +++ + T+ L Q L+
Sbjct: 191 ELRE-ELQMDQQAKKHLQEEFD------ASLEEKDQYISVLQTQVSLLKQR---LRNGPM 240
Query: 165 QVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLE 224
VD L + Q + + E+ S + + L +K ++ ++ +
Sbjct: 241 NVD-VLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCK 299
Query: 225 KELETQTGYVQKLQLQKEALDEQL-----FLVKEAECNMSSPKREI-------------- 265
+ +++ L +KEAL EQL L K + +M+ + I
Sbjct: 300 ETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLE 359
Query: 266 --PGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQC 323
G ++ L ++ IA+L + I+++ + EL ++ ++E+
Sbjct: 360 QDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQG-------EELREQKEKSERAA 412
Query: 324 KPLLERNKCLAKRNDELMVSLQ-RMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQ 382
LE+ A++ +E L+ M+E++K + K + E E+I+ L ++K +D
Sbjct: 413 FEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEE--ERISLQQELSRVKQ-EVVDV 469
Query: 383 ANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSM 442
+ E + KLQ + ++ EL R ++L ++ + R + +
Sbjct: 470 MKKSSEEQIAKLQKLHEK----ELARKEQELTKKLQTR-----------------EREFQ 508
Query: 443 DSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGI 502
+ ++ +++ + + + ESLA EE EL+ + A+L E +
Sbjct: 509 EQMKVALEKSQSEYLKISQEKEQQESLALEELELQKK-------------AILTESENKL 555
Query: 503 IDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFI-------KRNQE 555
D ++EA+ Y+ +I +LE++L +K + + K L + K N+E
Sbjct: 556 RDLQQEAET----------YRTRILELESSL-EKSLQENKNQSKDLAVHLEAEKNKHNKE 604
Query: 556 LLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSAL 615
+ +EK + EL+ + Q + L L++ +++ + + L
Sbjct: 605 ITVMVEKHKT-------ELESLKHQQDALWTEKLQVLKQQ------------YQTEMEKL 645
Query: 616 QIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEA 675
+ C +E L+K +I I QA + + EK +++++ +
Sbjct: 646 REKCEQEK------ETLLKDKEI--------------IFQAH-IEEMNEKTLEKLDVKQT 684
Query: 676 ALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATL-----YNALQQE 730
L L S++ + K + LEEEL K DQ QELEA + ++ Q +
Sbjct: 685 ELE----SLSSELSEVLKARHKLEEELSVLK---DQTDKMKQELEAKMDEQKNHHQQQVD 737
Query: 731 TVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQ 778
++IK E+ ++ ++ L+ + +L ++L K R+ + Q +E L+
Sbjct: 738 SIIKEHEVSIQRTEKALKDQINQL--ELLLKERDKHLKEHQAHVENLE 783
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 100 bits (249), Expect = 5e-21
Identities = 183/818 (22%), Positives = 341/818 (41%), Gaps = 112/818 (13%)
Query: 26 LRTKLTDIQIELHQEK--SKVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLH--EEK 81
LR ++ D+Q L +EK S+ K E EK Q ++ ++ K LVT+ A+L E++
Sbjct: 88 LRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQ----QEAKPDGLVTDSSAELQSLEQQ 143
Query: 82 MKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSAL---CALRDGSSDKVRTALTIEAR 138
++E Q N IKQ + + EI +KS +LR+ + KV T LT E
Sbjct: 144 LEEAQTENFN-IKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV-TRLTEELN 201
Query: 139 EEARKLFD--TERLKL--LQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEA 194
+EA + D TE L+ ++++A LK QV + NM + ++ L+ E + Q
Sbjct: 202 KEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQ 261
Query: 195 ISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEA 254
+ SE I +L E+ + + +EL+ V +L + + L E L L KE
Sbjct: 262 YA----SSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENL-LKKEQ 316
Query: 255 ECNMSSPK---REIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNE 311
+ K + + + H D ++ Q R++ ++ ++ + G+ +
Sbjct: 317 DYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQK 376
Query: 312 LLKRVRETEKQCKPLLERNKCLAKRNDEL-MVSLQRMEEKLKAVTKENSEMREKITSHPP 370
L + + E E + + L K L ++ +E LQ E + +K R+ +H
Sbjct: 377 LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGR 436
Query: 371 LKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPV 430
LK+ + L+ ++EQ+ L+L +L+R E+L K + ++ +
Sbjct: 437 LKEQRQLSSEKLMDKEQQVADLQL----------KLSRLEEQL----KEKVTNSTELQHQ 482
Query: 431 LDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQR 490
LD ++ + S+ A R +DL++ L RQ+ + Q +Q
Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLR------EAQNDLEQVL---------RQIGDKDQKIQN 527
Query: 491 AYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFI 550
ALLQ+ I E+E +E L A++ + + A L Q + +H ++++
Sbjct: 528 LEALLQKSKENISLLEKE---REDLYAKIQAGEGE----TAVLNQLQEKNHTLQEQV--- 577
Query: 551 KRNQELLEKIEKQEAENHRLQQELQD-ARDQNELLEFRNLELEERERRSPPFNLQIHPFS 609
+L EK++ Q + + Q+ L D ++Q L + E N Q++
Sbjct: 578 ---TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESK 634
Query: 610 DGVSAL--------QIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLS 661
+ VS L ++ E K DL LD T +
Sbjct: 635 EKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD--------------------TAQN 674
Query: 662 LAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEA 721
+ Q++ L Q +L+ E +++ +L+E Y+++ L + +ELE
Sbjct: 675 ALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE---YKEKYL-SLEQKTEELEG 730
Query: 722 TLYNALQQETVIKFGE---LLSEKQQEELRTAVEKLRRQMLRKSREYDCQI-------LQ 771
+ +K + L +QQ +L T +E LR L K E + +I LQ
Sbjct: 731 QIKKLEADSLEVKASKEQALQDLQQQRQLNTDLE-LRATELSKQLEMEKEIVSSTRLDLQ 789
Query: 772 ERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSNRKH 809
++ E L+ Q++ E++ I K+ + L +++ +H
Sbjct: 790 KKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827
Score = 97.1 bits (240), Expect = 6e-20
Identities = 170/872 (19%), Positives = 364/872 (41%), Gaps = 141/872 (16%)
Query: 19 LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQ--------RKHTVLV 70
LQ E+ +Q E++Q SK+ + ER+ + R++E Q ++ V
Sbjct: 398 LQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVAD 457
Query: 71 TELKAKLHEEKMKE-------LQAVRENLIKQHEQEM----SRTVKVR------------ 107
+LK EE++KE LQ + +QH+++ S T K+R
Sbjct: 458 LQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQ 517
Query: 108 ----DGEIQRLKSALCALRDGSS--DKVRTAL------------TIEAREEARKLFDTER 149
D +IQ L++ L ++ S +K R L + +E +
Sbjct: 518 IGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQV 577
Query: 150 LKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKW---ESERDI 206
+L +++ + + KQ E L + +Q K + S + +++++ ES+ +
Sbjct: 578 TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKV 637
Query: 207 RRLMDEIKAKDRIIFSLEKELETQTGYVQK-LQLQKEALDEQLFLVKEAECN-MSSPKRE 264
+L +IKAK ++ S E Q +Q L + AL + K+ E N +++ +
Sbjct: 638 SQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD-----KQQELNKITTQLDQ 692
Query: 265 IPGRAGDGSEHCSSPDLRRNQ---------KRIAELNATIRKLEDRNTLLGDERNELLKR 315
+ + D EHCS + + ++ EL I+KLE + + + + L+
Sbjct: 693 VTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQD 752
Query: 316 VRETEKQCKPLLERNKCLAKR--NDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKK 373
+++ + L R L+K+ ++ +VS R++ + K+ E+ +++K+T K+
Sbjct: 753 LQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES--IKQKLTKQEEEKQ 810
Query: 374 LKSLN----------DLDQANEEQETEFLKLQVI--EQQNIIDELTRDREKLIRRRKHRR 421
+ + ++ N +T +LQ + E++ ++ EL+ ++KL + +
Sbjct: 811 ILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLK 870
Query: 422 SSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLD---ESLAAEESELRF 478
+SK E +++ A ++T L E+ E+ EL+
Sbjct: 871 NSK-------------SEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK- 916
Query: 479 RQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQ 538
+ L KE +A + L +I A+ K E+ + ++ + I +L+ + QK
Sbjct: 917 KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQL---QGNINELKQSSEQK-- 971
Query: 539 DSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRS 598
KQ+ + + + ++K E EN +LQQ+L A + + + L+ +S
Sbjct: 972 ------KKQIEALQGELKIAVLQKTELEN-KLQQQLTQAAQELAAEKEKISVLQNNYEKS 1024
Query: 599 PPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQAST 658
Q+ G + ++ ++ +K V + Q D++ + + N+
Sbjct: 1025 QETFKQLQSDFYGRES-ELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQN--------- 1074
Query: 659 VLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQE 718
K IQ+++ A+A L Q + E +++ CK +++E +++ L ++ E
Sbjct: 1075 ------KLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAE 1128
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELR--TAVEKLRRQMLRKSREYDCQILQERMEL 776
+E Q++ + K E L + E ++ T ++ ++ ++++ E LQ + +
Sbjct: 1129 IEE--IKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLE-----LQGKADS 1181
Query: 777 LQQAHQRIRDLEDKTDIQKRQIKDLEEKSNRK 808
L+ A + + I K Q+K EE+ ++
Sbjct: 1182 LKAA---VEQEKRNQQILKDQVKKEEEELKKE 1210
Score = 84.0 bits (206), Expect = 5e-16
Identities = 158/800 (19%), Positives = 324/800 (40%), Gaps = 133/800 (16%)
Query: 10 EKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVL 69
++ +A + A Q L T + ++ +L++ K KVS+L+ + + + + E K T
Sbjct: 603 QEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAK-TAQ 661
Query: 70 VTELKAKLH------EEKMKELQAVRENL--IKQHEQEMSRTVKVRDGEIQRLKSALCAL 121
+L+ L ++K +EL + L + Q+ + ++ K +L
Sbjct: 662 RADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSL 721
Query: 122 RDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKA 181
+ + +EA K + L+ LQ+ L T + LS ++ +K
Sbjct: 722 EQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIV 781
Query: 182 GDLRSEHQSHQEAISKIKWES----------ERDIRRLMDEIKAKDRIIFSLEKELETQT 231
R + Q EA+ IK + ++D L E K + L ++T
Sbjct: 782 SSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHE---ELNNRIQTTV 838
Query: 232 GYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAEL 291
+QK++++KEAL +L VK+ +S D ++ S + NQK
Sbjct: 839 TELQKVKMEKEALMTELSTVKDKLSKVS-----------DSLKNSKSEFEKENQKG---- 883
Query: 292 NATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKL 351
A I LE L + ++ + +K+ K LE+ K + + +L + L M+E+L
Sbjct: 884 KAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK---EASHQLKLELNSMQEQL 940
Query: 352 ---KAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEF------LKLQVIEQQNI 402
+ K+N + +++ + +N+L Q++E+++ + LK+ V+++ +
Sbjct: 941 IQAQNTLKQNEKEEQQLQGN--------INELKQSSEQKKKQIEALQGELKIAVLQKTEL 992
Query: 403 -----------IDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDS------- 444
EL ++EK+ + + S+ + + F G + + + +
Sbjct: 993 ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 445 -ETSSMAS--FRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGG 501
E S+A ++R + L + L ++ L KE Q +R AL Q
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1112
Query: 502 IIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVED----------KQLFI- 550
+ E+E ++ AE+ K + ++ E T + SH +E KQL I
Sbjct: 1113 SLK-EKELVNEKSKLAEIEEIKCR-QEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQ 1170
Query: 551 -------------------KRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLEL 591
KRNQ++L+ K+E E + + ++A+ +E+ E + + +
Sbjct: 1171 QKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKE-KEVGM 1229
Query: 592 EERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDV-NIPDLIKQLDILGDNGNLRNEEQ 650
++ E +QI ++ + ++ KE + +L KQ D +LR E
Sbjct: 1230 KKHEENEAKLTMQITALNENLGTVK----KEWQSSQRRVSELEKQTD------DLRGE-- 1277
Query: 651 VAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALD 710
+A+++A+ +Q + AL ++ ++ E ++E+ L+ +LD A+
Sbjct: 1278 IAVLEAT---------VQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQ 1328
Query: 711 QAYMRIQELEATLYNALQQE 730
+ Q L+ AL ++
Sbjct: 1329 ELGRENQSLQIKHTQALNRK 1348
Score = 59.7 bits (143), Expect = 1e-08
Identities = 103/566 (18%), Positives = 229/566 (40%), Gaps = 93/566 (16%)
Query: 8 KGEKPEALIVALQAANEDLRTKLTDIQIE--LHQEKSKVSKLEREKTQEAKRIRELEQRK 65
+ +K +A I+ L+ ++L+ +L +Q+E L ++K LE+EK + EL +
Sbjct: 879 ENQKGKAAILDLEKTCKELKHQL-QVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQ 937
Query: 66 HTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGS 125
++ + K +E++ ++LQ N +KQ ++ + ++ GE++
Sbjct: 938 EQLIQAQNTLKQNEKEEQQLQG-NINELKQSSEQKKKQIEALQGELK------------- 983
Query: 126 SDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLR 185
+ + + E + + QE+A A+K+ L N + + L+
Sbjct: 984 -------IAVLQKTELENKLQQQLTQAAQELA----AEKEKISVLQNNYEKSQETFKQLQ 1032
Query: 186 SEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALD 245
S+ + + + +D++ + +++ + S ++ Q +Q+L+ K L+
Sbjct: 1033 SDFYGRESEL----LATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLE 1088
Query: 246 EQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLL 305
+ ++ ++I + +L + ++AE+ + E T L
Sbjct: 1089 QDSAKKEQQLQERCKALQDI-----QKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL 1143
Query: 306 GDE-RNELLKRVRETE--KQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMR 362
+E ++ L+ ++E K K LL + K + LQ + LKA ++ +
Sbjct: 1144 NEELKSHKLESIKEITNLKDAKQLLIQQK----------LELQGKADSLKAAVEQEKRNQ 1193
Query: 363 EKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRS 422
+ + DQ +E+E LK + IE++ + +++E +++ + +
Sbjct: 1194 QILK--------------DQVKKEEEE--LKKEFIEKEAKLHSEIKEKEVGMKKHEENEA 1237
Query: 423 SKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLT 482
++ L+ +G + S ++ DDL +A E+ ++ Q
Sbjct: 1238 KLTMQITALNENLGTVKKEWQSSQRRVSELEKQ------TDDLRGEIAVLEATVQNNQ-- 1289
Query: 483 KEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHW 542
ALL+ + E E E+LQ +VL + K+++ A + + G+
Sbjct: 1290 ------DERRALLER----CLKGEGEI---EKLQTKVLELQRKLDNTTAAVQELGR---- 1332
Query: 543 VEDKQLFIKRNQELLEK-IEKQEAEN 567
E++ L IK Q L K E E +N
Sbjct: 1333 -ENQSLQIKHTQALNRKWAEDNEVQN 1357
Score = 33.5 bits (75), Expect = 0.81
Identities = 60/292 (20%), Positives = 123/292 (42%), Gaps = 50/292 (17%)
Query: 537 GQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERER 596
G DS + L +KR+ L + E Q+ + +++ + EL +++ L+ +E +
Sbjct: 67 GNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAK- 125
Query: 597 RSPPFNLQIHPFSDGV---SALQIYCMKEGVKDVNIPDL-IKQLDILGDNGNLRNEEQVA 652
DG+ S+ ++ +++ +++ + IKQ+ L EQ A
Sbjct: 126 ------------PDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDL--------FEQKA 165
Query: 653 IIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQA 712
A+ + + K+ ++ EAA QK+ L ++ + + L+ EL R D A
Sbjct: 166 AQLATEIADIKSKYDEERSLREAA-EQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVA 224
Query: 713 YMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQ---------MLRKSR 763
++ +EL +Q +T++ L E++ E+L+ +KL+ Q LR
Sbjct: 225 VLK-KEL-------VQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSEL 276
Query: 764 EYDCQILQERMELLQQAHQRIRDLEDKTDI-------QKRQIKDLEEKSNRK 808
Q + ++ LQ+ + +L K +++ LEEK N +
Sbjct: 277 AKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEE 328
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 100 bits (248), Expect = 7e-21
Identities = 180/822 (21%), Positives = 346/822 (42%), Gaps = 100/822 (12%)
Query: 19 LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTE--LKAK 76
L+ E L+ + Q EL +E+ ++ KLER QE +R R+ E+++ L E L+ K
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLER---QELRRERQEEEQQQQRLRREQQLRRK 309
Query: 77 LHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIE 136
EE+ ++ + RE ++ +QE R ++R + +R + L R+ ++ L E
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQL--RREQEEERREQQLRRE 367
Query: 137 AREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAIS 196
EE R+ ++L+ Q++ + +++ ++ ++ LR E Q +E
Sbjct: 368 QEEERRE----QQLRREQQLRREQQLRREQQLRREQQLRREQ----QLRREQQLRREQ-- 417
Query: 197 KIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAEC 256
+ E+ +RR +E + + + E+E Q +L++E + + +L +E E
Sbjct: 418 --QLRREQQLRREQEEERHEQKH----EQERREQ-------RLKREQEERRDWLKREEET 464
Query: 257 NMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRV 316
+R L+R+Q+ E KLE+ ER E R
Sbjct: 465 ERHEQERR-------------KQQLKRDQEE--ERRERWLKLEEEERREQQERREQQLR- 508
Query: 317 RETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKS 376
RE E++ + L+R + +E + R E++L+ +E E RE++ K+L+
Sbjct: 509 REQEERREQRLKRQE-----EEERLQQRLRSEQQLR---REQEERREQLLKREEEKRLEQ 560
Query: 377 LNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHR----------RSSKPI 426
+ EQE +L E++ L R++E+ + +R R R + +
Sbjct: 561 ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Query: 427 KRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQ-LTKEY 485
KR +P + + SE R + + ++ L EE E R Q L +E+
Sbjct: 621 KRE--EPEEERRQQLLKSE--EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREH 676
Query: 486 QALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVED 545
+ +R L +E+ + +A+E++++ + +++ ++E EA Q S
Sbjct: 677 EEERREQELAEEE---------QEQARERIKSRIPKWQWQLES-EADARQSKVYSR--PR 724
Query: 546 KQLFIKRNQELLEKIEKQEAE--------NHRLQQELQDARDQNELLEFRNLELEERERR 597
KQ +R QE EK ++E+E HR QQE + RD + R+R
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRL 784
Query: 598 S--PPFNLQIH---PFSDGVSALQIYCMKEGVKDV---NIPDLIKQLDILGDNGNLRNEE 649
S PP Q + Q + +E K+ + K+L L + L+ E
Sbjct: 785 SARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844
Query: 650 QVAIIQAST--VLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQ 707
+ +Q + E+ Q + + ++ E K L+E+L +Q
Sbjct: 845 RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ 904
Query: 708 ALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDC 767
L + +Q E +QE + E L +++++ LR EK RRQ + D
Sbjct: 905 LLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDK 964
Query: 768 QILQERMELL-QQAHQRIRDLEDKTDIQKRQIKDLEEKSNRK 808
++ Q+ +LL ++ +R R +K ++ +++ EE+ R+
Sbjct: 965 KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLRE 1006
Score = 94.7 bits (234), Expect = 3e-19
Identities = 166/795 (20%), Positives = 340/795 (42%), Gaps = 71/795 (8%)
Query: 39 QEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQ 98
+E+++ + ER K Q+ KR +E E+R+ + KL EE+ +E Q RE +++ ++
Sbjct: 461 EEETERHEQERRK-QQLKRDQEEERRERWL-------KLEEEERREQQERREQQLRREQE 512
Query: 99 EMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIAD 158
E R E +RL+ L + L E E +L E K L++
Sbjct: 513 ERREQRLKRQEEEERLQQRL---------RSEQQLRREQEERREQLLKREEEKRLEQERR 563
Query: 159 LKTAKKQVDEALSNMIQADKIKAG-------DLRSEHQSHQEAISKIKWESERDIRRLMD 211
+ K++ +E +++ ++ + + R E + +E + +++ E R+ +RL
Sbjct: 564 EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE-QRLKR 622
Query: 212 EIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPG--RA 269
E ++R L+ E + + Q + Q+E +++L +E E KRE R
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682
Query: 270 GDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLER 329
+ +E R + RI + + D R + R ++Q + R
Sbjct: 683 QELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742
Query: 330 NKCLAKRNDELMVSLQRMEEKLKAVT-----KENSEM-REKITSHPPLKKLKSLNDLDQA 383
L + +E Q+ EE+ + T +E SE R+++++ PPL++ + +
Sbjct: 743 ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802
Query: 384 NEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMD 443
+++E FL + ++Q R R + + + + ++R + +ED +
Sbjct: 803 RQQREQRFLPEEEEKEQR-----RRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQ 857
Query: 444 SETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKE--YQALQRAYALLQEQTGG 501
+ S R D L E R K + L++ LLQE+
Sbjct: 858 EDQERRRSQEQRR-----DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEE 912
Query: 502 IIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIE 561
+ ERE K + Q Q R + +++ E L ++ ++ ++++ +++++L +K E
Sbjct: 913 LQREERE-KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE 971
Query: 562 K---QEAENHRLQQELQDARDQNELL-EFRNLELEERERRSPPFNLQIHPFSDGVSALQI 617
+ +E E R Q+ + R++ EL E L EERE+R + + D + +
Sbjct: 972 QLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEE 1031
Query: 618 YCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAAL 677
++E + + + +Q R EE++ Q L E+ ++ + E
Sbjct: 1032 QLLREEREKRRLQERERQY---------REEEELQ--QEEEQLLGEERETRRRQELERQ- 1079
Query: 678 HQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGE 737
++K EL+ + EQ + EE R+Q ++ +EL+ L++E + +
Sbjct: 1080 YRKEEELQQEEEQLLR-----EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ 1134
Query: 738 LLSE--KQQEELRTAVEKLRRQMLRKSREYDCQ-ILQERMELLQQAHQRIRDLEDK-TDI 793
L +++EE++ E+L R+ K R + + +E EL Q+ Q +R+ ++K
Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQE 1194
Query: 794 QKRQIKDLEEKSNRK 808
++RQ ++ EE +K
Sbjct: 1195 RERQYREEEELQRQK 1209
Score = 91.7 bits (226), Expect = 3e-18
Identities = 172/841 (20%), Positives = 351/841 (41%), Gaps = 127/841 (15%)
Query: 36 ELHQEKSKVSKLEREKTQEAKRIR------ELEQRKHTVLVTELKAKLHEE------KMK 83
EL QE+ ++ + EREK + +R R EL+Q + +L E + + +E K +
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084
Query: 84 ELQAVRENLIKQHEQEMSRTVKVR----DGEIQRLKSALCALRDGSSDKVRTALTIEARE 139
ELQ E L+++ ++ R + R + E+Q+ + L LR+ + R L + RE
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQL--LREEREKRRRQELERQYRE 1142
Query: 140 EARKLFDTERL-------KLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQ 192
E + E+L + QE+ ++++ + +++ ++ K R +
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE 1202
Query: 193 EAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVK 252
E + + K + +R DE + D + E E + K +EQ ++
Sbjct: 1203 EELQRQKRK-----QRYRDEDQRSD---LKWQWEPEKENAVRDNKVYCKGRENEQFRQLE 1254
Query: 253 EAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIA--------------ELNATIRKL 298
+++ ++++ G+ E + RR Q+R E RK
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKS 1314
Query: 299 EDRNTLLGDERNELLKRVRET------------EKQCKPLLERNKCLAKRNDELMVSLQR 346
++ LL +ER E +R +ET E++ +PL + + R +EL R
Sbjct: 1315 QEEKQLLREEREEKRRR-QETDRKFREEEQLLQEREEQPLRRQERDRKFREEEL-----R 1368
Query: 347 MEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQ---NII 403
+E+ + +E +R + LK+ + L ++ + ++ K + EQQ
Sbjct: 1369 HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428
Query: 404 DELTRDREKLIRRRKHRRS----SKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPA 459
D R+ E+ +RR++ R + +++ F ++ + E + DR
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488
Query: 460 TPDDDL----------DESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREA 509
+ L ++ L ++E E +F + ++ QR LQE+ R+
Sbjct: 1489 EEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQ----QLRRQE 1544
Query: 510 KAQEQLQAEVLRYKA----KIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEA 565
+ Q++ Q +++ + E E L+++ +D + ++Q ++ QE ++Q+
Sbjct: 1545 RGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQL 1604
Query: 566 ENHRLQQELQDARDQNELLEFRNLE--LEERERRSPPFNLQIHPFSDGVSALQIYCMKEG 623
QQ+L+ RD+ +FR E L+ERE + Q+H
Sbjct: 1605 RRQEGQQQLRQERDR----KFREDEQLLQEREEQ------QLH---------------RQ 1639
Query: 624 VKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMME 683
+D + QL LR++ + +L E+ QQ+ E +K E
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE--QQLRRQER--DRKFRE 1695
Query: 684 LESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQEL-EATLYNALQQETVIKFGELLSEK 742
E + + + + +L+EE R+Q L++ + ++L + T L+++ ++ ++L E+
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQE--RYRKILEEE 1753
Query: 743 QQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLE 802
Q R + R++ RK RE + Q+ QER E QQ + D + + + Q RQ ++ +
Sbjct: 1754 QLRPEREEQQLRRQERDRKFREEE-QLRQEREE--QQLRSQESDRKFREEEQLRQEREEQ 1810
Query: 803 E 803
+
Sbjct: 1811 Q 1811
Score = 91.3 bits (225), Expect = 3e-18
Identities = 175/841 (20%), Positives = 344/841 (40%), Gaps = 106/841 (12%)
Query: 20 QAANEDLRTKLTDIQIELHQEK-SKVSKL-EREKTQEAKRIRELEQRKHTVLVTELK--- 74
+ A E +++++ Q +L E ++ SK+ R + QE +R R+ ++ K +EL+
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750
Query: 75 -AKLHEEKMKELQA-------VRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSS 126
+ H ++ +E Q E ++ Q +S +R+ ++L++ +
Sbjct: 751 EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA------EERQ 804
Query: 127 DKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRS 186
+ + L E +E R+ ER K LQ + + + +++ E + + + D
Sbjct: 805 QREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRR--ERAQQLQEEEDGLQEDQER 862
Query: 187 EHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKE---LETQTGYVQKLQLQKEA 243
Q K +W+ E + +R + AK + L KE L+ + +Q+ + +K
Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRR 922
Query: 244 LDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNT 303
EQ +E E ++ + + RR Q+R + + +
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLR----------EEREKRRRQERERQYRKDKKLQQKEEQ 972
Query: 304 LLGDE-----RNELLKRVRETEK--QCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTK 356
LLG+E R E K+ RE E+ Q + L R + +R E ++ +E + +
Sbjct: 973 LLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQ 1032
Query: 357 ENSEMREKITSHPPLKKLKSLNDLDQANEE---QETEFLKLQVIEQQ-NIIDELTRDREK 412
E REK ++ + +L Q E+ +E E + Q +E+Q +EL ++ E+
Sbjct: 1033 LLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQ 1092
Query: 413 LIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDL------- 465
L+R +R + +R + +E+ E + R R +
Sbjct: 1093 LLREEPEKRRRQERERQCRE-----EEELQQEEEQLLREEREKRRRQELERQYREEEEVQ 1147
Query: 466 --DESLAAEESELRFRQ-LTKEYQA-----LQRAYALLQEQTGGIIDAEREAKAQEQLQA 517
+E L EE E R RQ L ++Y+ + L +EQ + ER+ + +E+LQ
Sbjct: 1148 QEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQR 1207
Query: 518 EVLRYKAKIEDLEATLAQKGQDS--HWVEDKQLFIK-RNQELLEKIEKQEAENHRLQQEL 574
+ + + + ED + L + + + V D +++ K R E ++E + + + QQ+L
Sbjct: 1208 QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDL 1267
Query: 575 QD--ARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDL 632
Q Q E ++R+R P L+ KE +
Sbjct: 1268 QHLLGEQQERDREQERRRWQQRDRHFPE-----------EEQLEREEQKEAKRRDRKSQE 1316
Query: 633 IKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMEL---ESDME 689
KQL LR E + + T E+ E E L ++ + E ++
Sbjct: 1317 EKQL--------LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR 1368
Query: 690 QFCKIKGYLEEELDYRKQALDQAYM------RIQELEATLYNALQQETVIKFGELLSEKQ 743
+ + +LEEE R+Q ++ ++ R QE E L+Q+ KF E +
Sbjct: 1369 HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE----QQLRQDRDRKFREEEQQLS 1424
Query: 744 QEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEE 803
++E + +Q+ R+ RE + L+E +L Q+ H++ R E++ +Q+R+ + L
Sbjct: 1425 RQERDRKFREEEQQVRRQERER--KFLEEEQQLRQERHRKFR--EEEQLLQEREEQQLHR 1480
Query: 804 K 804
+
Sbjct: 1481 Q 1481
Score = 90.1 bits (222), Expect = 7e-18
Identities = 182/912 (19%), Positives = 368/912 (40%), Gaps = 128/912 (14%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRI-RELEQR 64
R + E+ E L+ + + L + + +++ QE+ + L+RE+ + +R+ RE E+R
Sbjct: 540 REQEERREQLLK--REEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597
Query: 65 KHTVLVTELKAKLHEEKMKELQAVREN--------LIKQHEQEMSRTVKVRDGEIQRLKS 116
L E +L +E+ +E + RE L+K EQE R ++R + +R +
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQ 657
Query: 117 ALCALRDGSSDKVRTALTIEAREEARK--LFDTERLKLLQEIADLKTA-----KKQVDEA 169
L R+ +++ L E EE R+ L + E+ + + I + + D
Sbjct: 658 RL--KREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715
Query: 170 LSNMIQADKIKAGDLRSEHQSHQEAI--SKIKWESERDIRRLMDEIKAKDRIIFSLEKEL 227
S + + + G R + Q + S+++W+ E R E + + + + E
Sbjct: 716 QSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775
Query: 228 ETQTGYVQ-------------KLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSE 274
+++ G + +L+ ++ EQ FL +E E +R + E
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835
Query: 275 HCSSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLK-RVRETEKQCKPLLERNKCL 333
R +++ E +++ ++R R++ + ++ E K+ + L L
Sbjct: 836 EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPAL 895
Query: 334 AKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL----------DQA 383
++ + LQ EE+L+ +E +E+ + ++L+ + Q
Sbjct: 896 QEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955
Query: 384 NEEQETEFLKLQVIEQQNI------------------IDELTRDREKLIRRRKHRRSSKP 425
E Q + KLQ E+Q + +EL ++ E+L+R + +R +
Sbjct: 956 RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015
Query: 426 IKRPVLDPF-IGYDEDSMDSETSSMASFRTDRTPATPDDDL---DESLAAEESELRFRQ- 480
+R + +E+ + E + +++L +E L EE E R RQ
Sbjct: 1016 WERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE 1075
Query: 481 ----LTKEYQALQRAYALLQEQTGGII--DAEREAKAQEQLQAEVL------RYKAKIED 528
KE + Q LL+E+ + ER+ + +E+LQ E R K + ++
Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQE 1135
Query: 529 LEATLAQKGQDSHWVEDKQLFI-----KRNQELLEKIEKQEA---ENHRLQQELQDARDQ 580
LE ++ + E++QL +R QEL + ++E E +L +E Q+ R Q
Sbjct: 1136 LERQYREEEEVQQ--EEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193
Query: 581 NELLEFRNLELEERERRSPPFN---------LQIHPFSDG-VSALQIYCMKEG------V 624
++R E +R++R + Q P + V ++YC +
Sbjct: 1194 ERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253
Query: 625 KDVNIPDLIKQLDI---LGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKM 681
+D + D Q D+ LG+ E++ Q E+ +++ E EA +
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK 1313
Query: 682 MELESDMEQFCKIKGYLEEELDYRKQALDQAYMR----IQELEATLYNALQQETVIKFGE 737
+ E + + E E R+Q D+ + +QE E +++ + E
Sbjct: 1314 SQEEKQLLRE-------EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEE 1366
Query: 738 LLSEKQ-----QEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTD 792
L ++Q +EE R ++ R+ L++ ++ CQ + +L Q ++ R+ E +
Sbjct: 1367 LRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQ--EREQQLRQDRDRKFREEEQQLS 1424
Query: 793 IQKRQIKDLEEK 804
Q+R K EE+
Sbjct: 1425 RQERDRKFREEE 1436
Score = 90.1 bits (222), Expect = 7e-18
Identities = 164/789 (20%), Positives = 331/789 (41%), Gaps = 75/789 (9%)
Query: 49 REKTQEAKRIRELEQRKHTVLVTE----LKAKLHEEKMKELQAVRENLIKQHEQEMSRTV 104
RE+ + R E +QR+ L E + + E+ KELQ + E Q + +
Sbjct: 791 REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQ 850
Query: 105 KVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDT----ERLKLLQEIADLK 160
+ DG +Q + + K R L E + L+ E+L+ Q++ +
Sbjct: 851 EEEDG-LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEE 909
Query: 161 TAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRII 220
+ Q +E Q + + R E Q QE ++ E E+ R+ + KD+ +
Sbjct: 910 EEELQREEREKRRRQEQERQ---YREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKL 966
Query: 221 FSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPD 280
E++L + ++ Q +++ E+ L +E E + +RE R ++ +
Sbjct: 967 QQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEE-QLLREEREKRRRQEWERQYRKKDE 1025
Query: 281 LRRNQKRIAELNATIRKLEDRNTL------LGDERNELLKRVRETEKQCKPLLERNKCLA 334
L++ ++++ R+L++R L E +LL RET ++ + LER
Sbjct: 1026 LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE--LERQY--- 1080
Query: 335 KRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKL 394
R +E LQ+ EE+L +E E R + ++ + L ++ +E E +
Sbjct: 1081 -RKEE---ELQQEEEQL---LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR 1133
Query: 395 QVIEQQ-NIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFR 453
Q +E+Q +E+ ++ E+L+R +R + ++R + E+ + E +
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE------EEELQQEEEQLLREE 1187
Query: 454 TDRTPATPDDDL--DESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKA 511
++ + +E L ++ + R+R E Q + E+ + D + K
Sbjct: 1188 QEKRRQERERQYREEEELQRQKRKQRYRD---EDQRSDLKWQWEPEKENAVRDNKVYCKG 1244
Query: 512 QE-----QLQAEVLRYKAKIEDLEATLAQKGQ-------------DSHWVEDKQLFIKRN 553
+E QL+ LR + +DL+ L ++ + D H+ E++QL +
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 554 QELLEKIEKQEAENHRLQQELQDARDQNEL-LEFRNLELEERERRSPPFNLQIHP--FSD 610
+E + K + E L++E ++ R + E +FR E +ER P Q F +
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFRE 1364
Query: 611 GVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQI 670
Q K ++ + ++ L + LR +E+ ++ E+ QQ+
Sbjct: 1365 EELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEE-QQL 1423
Query: 671 EGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQE 730
E +K E E + + + + +LEEE R++ + + +E E L +Q+
Sbjct: 1424 SRQER--DRKFREEEQQVRRQERERKFLEEEQQLRQER----HRKFREEEQLLQEREEQQ 1477
Query: 731 T--VIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLE 788
+ + L E+QQ + K R Q LR S+E + + L+E +L +Q QR + L+
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELR-SQEPERKFLEEEQQLHRQQRQR-KFLQ 1535
Query: 789 DKTDIQKRQ 797
++ +++++
Sbjct: 1536 EEQQLRRQE 1544
Score = 80.5 bits (197), Expect = 6e-15
Identities = 171/829 (20%), Positives = 329/829 (39%), Gaps = 109/829 (13%)
Query: 43 KVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSR 102
K S L+ + +E +R E R+ + + + +E+ +EL E KQ E R
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQ-R 164
Query: 103 TVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTA 162
+ RD E+ R + + +++ + L E + D E+L+ +E+ +L+
Sbjct: 165 DRQRRDEELWRQRQEWQEREERRAEEEQ--LQSCKGHETEEFPDEEQLRR-RELLELRR- 220
Query: 163 KKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFS 222
K + ++ + D++ + E + + + K + + + + + E++ ++ +
Sbjct: 221 KGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK 280
Query: 223 LEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLR 282
LE++ + ++ Q Q+ ++QL +E E +R + E LR
Sbjct: 281 LERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR 340
Query: 283 RNQKRIAELNATIRKLEDRNTLL------GDERNELLKRV-------------------- 316
R Q+ E + E+R + R + L+R
Sbjct: 341 REQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQ 400
Query: 317 --------RETEKQCKPLLERNKCLAKRND----ELMVSLQRMEEKLKAVTKENSE--MR 362
RE + + + L R + L + + E +R E++LK +E + R
Sbjct: 401 LRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKR 460
Query: 363 EKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRS 422
E+ T ++ K DQ EE+ +LKL+ E++ E RE+ +RR + R
Sbjct: 461 EEETERHEQERRKQQLKRDQ-EEERRERWLKLEEEERR----EQQERREQQLRREQEERR 515
Query: 423 SKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLT 482
+ +KR + E R+++ ++ E L E E R Q
Sbjct: 516 EQRLKR-------------QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562
Query: 483 KEYQALQRAYALLQEQTGGIIDAEREAKAQ--EQLQAEVLRYKAKIEDLEATLAQKGQDS 540
+E QR +E+ ++ E E + Q ++ Q E L + K E++E L Q+ +
Sbjct: 563 RE----QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE-RLEQEERRE 617
Query: 541 HWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPP 600
++ ++ +R Q+LL+ E++E +L++E Q+ R+Q E LE+R +R
Sbjct: 618 QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677
Query: 601 FNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVL 660
+ ++ +E +K IP QL E A + S V
Sbjct: 678 EERREQELAEEEQEQ----ARERIKS-RIPKWQWQL------------ESEADARQSKVY 720
Query: 661 SLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEE-----LDYRKQALDQAYMR 715
S K Q E ++ E E ++ + +EE ++ QA +++
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 716 IQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERME 775
Q L A Q+E ++ E +++Q L EK +R+ R+ RE + Q L+E +
Sbjct: 781 RQRLSARPPLREQRERQLR-AEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ 839
Query: 776 L---------------LQQAHQRIRDLEDKTDIQKRQIKDLEEKSNRKH 809
L LQ+ +R R E + D QK + + EE+ R+H
Sbjct: 840 LQRRERAQQLQEEEDGLQEDQERRRSQEQRRD-QKWRWQLEEERKRRRH 887
Score = 77.4 bits (189), Expect = 5e-14
Identities = 166/815 (20%), Positives = 333/815 (40%), Gaps = 146/815 (17%)
Query: 36 ELHQEKSKVSKLEREKTQEAKRIRE------LEQRKHTVLVTELKAKLHEEKMK------ 83
+L QE+ ++ + EREK + +R R+ L+Q++ +L E + + +E+ K
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE 994
Query: 84 -----ELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAR 138
E Q +RE K+ QE R + +D E+Q+ + L R
Sbjct: 995 ELQQEEEQLLREEREKRRRQEWERQYRKKD-ELQQEEEQLL------------------R 1035
Query: 139 EEARKLFDTERLKLLQEIADLKTAKKQV-----DEALSNMIQADKIKAGDLRSEHQS--H 191
EE K ER + +E +L+ ++Q+ + ++ K +L+ E +
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR 1095
Query: 192 QEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLV 251
+E + + E ER R +E++ ++ + E+E + ++ + ++E E+ L+
Sbjct: 1096 EEPEKRRRQERERQCRE-EEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 252 KEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNE 311
+E P+ RR Q+ + ++ LL +E+
Sbjct: 1155 RE------------------------EPEKRRRQELERQYREEEELQQEEEQLLREEQE- 1189
Query: 312 LLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLK-AVTKENSEMREKI-TSHP 369
KR +E E+Q + E + KR QR + K + KEN+ K+
Sbjct: 1190 --KRRQERERQYREEEELQR--QKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGR 1245
Query: 370 PLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRP 429
++ + L D Q + Q + L+ + EQQ RDRE+ RR + R P
Sbjct: 1246 ENEQFRQLED-SQLRDRQSQQDLQHLLGEQQE------RDREQERRRWQQRDRHFP---- 1294
Query: 430 VLDPFIGYDEDSMDSETSSMASFRTDRTPATPD---DDLDESLAAEESELRFRQ-----L 481
+E+ ++ E A R ++ ++ +E +E++ +FR+
Sbjct: 1295 --------EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQ 1346
Query: 482 TKEYQALQRAYA---------LLQEQTGGIIDAEREAKAQEQ-----LQAEVLRYKAKIE 527
+E Q L+R QEQ ++ E+ + QE+ + + LR + + +
Sbjct: 1347 EREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQ 1406
Query: 528 DLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFR 587
L +K ++ +Q ++ +E +++ +QE E L++E Q ++++
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466
Query: 588 NLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNL-R 646
L+ERE + + F + L+ ++ + + L + L R
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHR 1526
Query: 647 NEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQK-MMELESDMEQFCKIKGYLEEELDYR 705
+ Q +Q L E+ Q+ + + ++ + E + +Q + +E D R
Sbjct: 1527 QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSR------QERD-R 1579
Query: 706 KQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREY 765
K L++ +R QE E + + ++QQ + ++LR++ RK RE
Sbjct: 1580 KFRLEEQKVRRQEQER---------------KFMEDEQQLRRQEGQQQLRQERDRKFRE- 1623
Query: 766 DCQILQERMELLQQAHQRIRD---LEDKTDIQKRQ 797
D Q+LQER E QQ H++ RD LE++ +++++
Sbjct: 1624 DEQLLQEREE--QQLHRQERDRKFLEEEPQLRRQE 1656
Score = 66.2 bits (160), Expect = 1e-10
Identities = 122/603 (20%), Positives = 249/603 (41%), Gaps = 52/603 (8%)
Query: 36 ELHQEKSKVSKLEREKTQEAKRI-RELEQRKHTVLVTELKAKLHEEKMKELQA------- 87
+L +E+ K +K K+QE K++ RE + K T+ K + E+ ++E +
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE 1357
Query: 88 ----VRENLIKQHEQ-----EMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAR 138
RE ++ EQ E + ++ ++ E + LK ++R + R
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFR 1417
Query: 139 EEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKI 198
EE ++L ER + +E +++ + L Q + + R E Q QE +
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ 1477
Query: 199 KWESERDIRRLMDE--IKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQL---FLVKE 253
ERD + L +E ++ ++R E+EL +Q + L+ +++ +Q FL +E
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEE 1537
Query: 254 AECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGDE---RN 310
+ ++ R D + R ++ +L+ R+ DR L ++ R
Sbjct: 1538 QQLRRQERGQQ---RRQDRDRKFREEEQLRQEREEQQLS---RQERDRKFRLEEQKVRRQ 1591
Query: 311 ELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPP 370
E ++ E E+Q + + + +R+ + Q ++E+ + R+ + P
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQ 1651
Query: 371 LKKLKSLNDL--DQANEEQETEFLKLQVIEQQ---NIIDELTRDREKLIRR----RKHRR 421
L++ + L D+ + +E E L + EQQ D R+ E+ +RR RK +
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQ 1711
Query: 422 SSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDL------DESLAAEESE 475
+ ++R L+ +E+ + ET R +R +++ ++ L +E +
Sbjct: 1712 EEQQLRRQELERKFR-EEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD 1770
Query: 476 LRFRQLTKEYQALQRAYALLQEQTGGIIDAE--REAKAQEQLQAEVLRYKAKIEDLEATL 533
+FR+ + Q + QE + E R+ + ++QL+ + K + E+ + L
Sbjct: 1771 RKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQL 1830
Query: 534 AQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEE 593
++ Q D+Q R +E EK E L QE + R Q + R +
Sbjct: 1831 EEQEQRLRQERDRQY---RAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRR 1887
Query: 594 RER 596
+++
Sbjct: 1888 QQK 1890
Score = 62.8 bits (151), Expect = 1e-09
Identities = 121/599 (20%), Positives = 239/599 (39%), Gaps = 100/599 (16%)
Query: 24 EDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMK 83
E+ R + + + + +E+ ++ ERE+ R R+ + + + E K EE+ +
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQ 1438
Query: 84 ELQAVRENLIKQHEQEM--SRTVKVRDGE--IQRLKSALCALRDGSSDKVRTALTIEARE 139
+ RE + EQ++ R K R+ E +Q + ++ + + +E
Sbjct: 1439 VRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498
Query: 140 EARKLFDTE------RLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGD---------L 184
RK + E K L+E L ++Q + L Q + + G
Sbjct: 1499 RDRKFREQELRSQEPERKFLEEEQQLHRQQRQ-RKFLQEEQQLRRQERGQQRRQDRDRKF 1557
Query: 185 RSEHQSHQEAISKIKWESERDIRRLMDEIKAK----DRIIFSLEKELETQTGYVQKLQLQ 240
R E Q QE + ERD + ++E K + +R E++L Q G Q Q +
Sbjct: 1558 REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQER 1617
Query: 241 KEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLED 300
E L++E E ++++ + D P LRR ++ + RK +
Sbjct: 1618 DRKFREDEQLLQERE------EQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFRE 1671
Query: 301 RNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSE 360
LL + + L+R ER++ + + L+R E + K + +E
Sbjct: 1672 EEQLLQEGEEQQLRR-----------QERDRKFREEEQQ----LRRQERERKFLQEEQQL 1716
Query: 361 MREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQ-----VIEQQNIIDELTRDREKLIR 415
R+++ + + +Q +E E E L+ Q ++E++ + E R+ ++L R
Sbjct: 1717 RRQELE--------RKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPE--REEQQLRR 1766
Query: 416 RRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESE 475
+ + R+ F ++ + E + S +DR + E EE +
Sbjct: 1767 QERDRK------------FREEEQLRQEREEQQLRSQESDRKFREEEQLRQE---REEQQ 1811
Query: 476 LRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQ 535
LR +Q +Y+ + L +++ + +R+ +A+EQ + K++ E+ E
Sbjct: 1812 LRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQ---EKSRREEQEL---- 1864
Query: 536 KGQDSHWVEDKQLFIKRNQELLEKI-------EKQEAENHRLQQEL--QDARDQNELLE 585
W E++Q KR QE K+ +++E + HR E+ Q+ + LLE
Sbjct: 1865 ------WQEEEQ---KRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914
Score = 61.6 bits (148), Expect = 3e-09
Identities = 109/574 (18%), Positives = 242/574 (42%), Gaps = 57/574 (9%)
Query: 46 KLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQE----MS 101
+LERE+ +EAKR Q + +L E + K ++ E L+++ E++
Sbjct: 1298 QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE 1357
Query: 102 RTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKT 161
R K R+ E++ + L + + R + +E ++L ER + L++ D K
Sbjct: 1358 RDRKFREEELRHQEQGRKFLEEEQRLR-RQERERKFLKEEQQLRCQEREQQLRQDRDRKF 1416
Query: 162 AKKQVDEALSNMIQADKIKAGDLRSEHQSHQ----EAISKIKWESERDIRRLMDEIKAKD 217
++ ++ LS + K + + + Q + E +++ E R R +E ++
Sbjct: 1417 --REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE--EEQLLQE 1472
Query: 218 RIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCS 277
R L ++ + ++ QL+++ D + +E E P+R+
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKF---REQELRSQEPERKFLEEEQQLHRQQR 1529
Query: 278 SPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRN 337
+ ++++ ++ +DR+ +E E L++ RE ++ + +R L ++
Sbjct: 1530 QRKFLQEEQQLRRQERGQQRRQDRDRKFREE--EQLRQEREEQQLSRQERDRKFRLEEQK 1587
Query: 338 DELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVI 397
++R E++ K + E R++ ++ + + +Q +E+E + L Q
Sbjct: 1588 ------VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641
Query: 398 EQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRT 457
+++ + +E R++ ++ +H R K F ++ + E + DR
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRDRK---------FREEEQLLQEGEEQQLRRQERDRK 1692
Query: 458 PATPDDDL------------DESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDA 505
+ L ++ L +E E +FR+ + Q ++ QE+ I++
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE- 1751
Query: 506 EREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKI-EKQE 564
+EQL+ E + + ++ + ++ Q E++QL R+QE K E+++
Sbjct: 1752 ------EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQL---RSQESDRKFREEEQ 1802
Query: 565 AENHRLQQELQ-DARDQNELLEFRNLELEERERR 597
R +Q+L+ RD E L+LEE+E+R
Sbjct: 1803 LRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQR 1836
Score = 57.8 bits (138), Expect = 4e-08
Identities = 93/485 (19%), Positives = 200/485 (41%), Gaps = 68/485 (14%)
Query: 328 ERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQ 387
+R +C K E ++ +R EE + + ++ E+ K+ + +L + E+
Sbjct: 99 KRARCDGK---ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 388 ETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETS 447
E + +L+ ++Q +EL R R++ R + R +E
Sbjct: 156 EKQE-RLEQRDRQRRDEELWRQRQEWQEREERR-----------------------AEEE 191
Query: 448 SMASFRTDRTPATPDDDLDESLAAEESELRFR-QLTKEYQALQRAYALLQEQTGG----- 501
+ S + T PD++ + E ELR + + K+ Q +R + QE+
Sbjct: 192 QLQSCKGHETEEFPDEE--QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKR 249
Query: 502 -IIDAEREAKAQE---QLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELL 557
+ + E K QE Q Q E+ + ++ LE ++ + E +Q ++R Q+L
Sbjct: 250 ETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE--EQQQQRLRREQQLR 307
Query: 558 EKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQI 617
K E++ E ++E Q+ R+Q E + L E+ ERR + +
Sbjct: 308 RKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR------REQEEERRE 361
Query: 618 YCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAAL 677
++ ++ +++ L LR E+Q+ + QQ+ +
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRREQQL-------------RREQQLRREQQLR 408
Query: 678 HQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGE 737
++ + E + + +++ EEE +K ++ R++ + + L++E + E
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHE 468
Query: 738 LLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELL------QQAHQRIRDLEDKT 791
E+++++L+ E+ RR+ K E + + QER E ++ QR++ E++
Sbjct: 469 --QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE 526
Query: 792 DIQKR 796
+Q+R
Sbjct: 527 RLQQR 531
Score = 48.5 bits (114), Expect = 2e-05
Identities = 75/332 (22%), Positives = 144/332 (43%), Gaps = 44/332 (13%)
Query: 485 YQALQRAYALLQEQTGGIIDAEREAKA-------QEQLQAE-VLRYKAKIEDLEATLAQK 536
++ Q Y L + TG +D E+ A+ Q++ Q E R++ + LE Q+
Sbjct: 79 FKVAQACYYALGQATG--LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQR 136
Query: 537 GQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERER 596
+ ++++L E E+ EKQE RL+Q + RD+ EL R E ER
Sbjct: 137 RRQKRQEQEREL-----AEGEEQSEKQE----RLEQRDRQRRDE-ELWRQRQEWQEREER 186
Query: 597 RSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQA 656
R+ LQ C ++ + +++ ++L R E+Q +
Sbjct: 187 RAEEEQLQS-------------CKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRER 233
Query: 657 STVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRI 716
+ E+ ++ E L ++ +L+ + Q + + EEE RK +
Sbjct: 234 QDRV-FQEEEEKEWRKRETVLRKEEEKLQEEEPQ--RQRELQEEEEQLRK-------LER 283
Query: 717 QELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMEL 776
QEL QQ+ ++ + L KQ+EE R E+ R Q R+ ++ + + Q R E
Sbjct: 284 QELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ 343
Query: 777 LQQAHQRIRDLEDKTDIQKRQIKDLEEKSNRK 808
++ Q++R E + + +++Q++ +E+ R+
Sbjct: 344 EERREQQLR-REQEEERREQQLRREQEEERRE 374
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 99.8 bits (247), Expect = 9e-21
Identities = 171/874 (19%), Positives = 369/874 (42%), Gaps = 147/874 (16%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR- 64
+ K E +AL + LQ ++L+ ++ +++ E+ E++ +K E++++ ++ + E+ +R
Sbjct: 1095 QGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154
Query: 65 KHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDG 124
+ T + ++++++ E Q +R +L + Q ++ ALR
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQH---------------EATAAALRKK 1199
Query: 125 SSDKV-RTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSN---MIQADKIK 180
+D V I++ + ++ + E+ +L EI DL + + V +A +N M + + +
Sbjct: 1200 HADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQ 1259
Query: 181 AGDLRSEHQSHQEAISKIKWESER------DIRRLMDEIKAKDRIIFSLEKELETQTGYV 234
+++++ + Q I+++ + R + R +DE KD ++ L + + T +
Sbjct: 1260 LSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDE---KDAMVSQLSRGKQAFTQQI 1316
Query: 235 QKLQLQKEALDEQLFLVKEA------ECNMS----SPKREIPGRAGDGSEHCSSPDLRRN 284
++L+ Q E + + A +C++ ++E G +S +
Sbjct: 1317 EELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWR 1376
Query: 285 QKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSL 344
K + +LE+ L + + V +C L + + L ++LM+ +
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDV 1436
Query: 345 QRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQE---TEFLKLQVI---- 397
+R A+ K+ +K+ + K ++ +L+ + +E TE K++
Sbjct: 1437 ERSNAACIALDKKQRNF-DKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEES 1495
Query: 398 ---------EQQNIIDELTRDREKLIRRRKHRRSSKPIKRPV------LDPFIGYDEDSM 442
E +N+ E++ E++ KH + +K+ + L + E S+
Sbjct: 1496 LDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASL 1555
Query: 443 DSETSSMASFRT---------DRTPATPDDDLDESLAAEESELRFRQLTKEYQALQR--A 491
+ E + + DR A D++LD+ + Q T + + R A
Sbjct: 1556 EHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDA 1615
Query: 492 YALLQEQTGGIIDAEREAKAQEQLQAEVLRY----KAKIEDLEATL--AQKGQDSHWVED 545
+ ++ G + + E + + AE LR + ++D + L A +GQD +++
Sbjct: 1616 LRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDD--LKE 1673
Query: 546 KQLFIKRN--------QELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERR 597
+ ++R +EL +E+ E +QEL DA ++ +LL +N L +++
Sbjct: 1674 QLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKK 1733
Query: 598 SPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQAS 657
+S +Q + D++++ RN E+ A +
Sbjct: 1734 ----------LETDISQIQ----------GEMEDIVQE---------ARNAEEKAKKAIT 1764
Query: 658 TVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQ-ALDQAYMRI 716
+AE+ +++ + A L + ++ +MEQ K L+ LD +Q AL +I
Sbjct: 1765 DAAMMAEE-LKKEQDTSAHLER----MKKNMEQTVK---DLQLRLDEAEQLALKGGKKQI 1816
Query: 717 QELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMEL 776
Q+LEA + L+ E E +Q+ AV+ LR+ R+ +E Q ++R +
Sbjct: 1817 QKLEARV-RELESEV---------ESEQKHNVEAVKGLRKHE-RRVKELTYQTEEDRKNI 1865
Query: 777 LQQAHQRIRDLEDKTDIQ----KRQIKDLEEKSN 806
L R++DL DK + KRQ ++ EE+SN
Sbjct: 1866 L-----RLQDLVDKLQTKVKAYKRQAEEAEEQSN 1894
Score = 90.9 bits (224), Expect = 4e-18
Identities = 174/836 (20%), Positives = 340/836 (40%), Gaps = 150/836 (17%)
Query: 1 MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRE 60
++K + E E ++ +Q N DL+ ++ L + + +L + K Q +I+E
Sbjct: 867 LAKTEAKRKELEEKMVTLMQEKN-DLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKE 925
Query: 61 LEQRKH-----TVLVTELKAKLHEE----------------KMKELQAVRENLIKQHEQE 99
+ +R +T K KL +E K+++ + EN +K +E
Sbjct: 926 VTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 985
Query: 100 MSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADL 159
M+ D I +L AL++ +T ++ E+ + KL Q++ DL
Sbjct: 986 MAGL----DETIAKLTKEKKALQEAHQ---QTLDDLQMEEDKVNTLTKAKTKLEQQVDDL 1038
Query: 160 KTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRI 219
+ + +Q + ++ +A + GDL+ +S + +E D ++L +++K K+
Sbjct: 1039 EGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMD--------TENDKQQLNEKLKKKEFE 1090
Query: 220 IFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPG-RAGDGSEHCSS 278
+ +L+ ++E + +QLQK+ +KE + + + EI RA
Sbjct: 1091 MSNLQGKIEDEQALA--IQLQKK--------IKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 279 PDLRRNQKRIAE--------LNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERN 330
DL R + I+E +A I + R R +L + + E L +++
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKH 1200
Query: 331 KCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKI----TSHPPLKKLKSLNDLDQANEE 386
E + SLQR+++KL+ KE SE++ +I ++ + K K+ + E
Sbjct: 1201 ADSVAELGEQIDSLQRVKQKLE---KEKSELKMEINDLASNMETVSKAKANFEKMCRTLE 1257
Query: 387 QETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET 446
+ +K + EQQ +I+EL+ + +L H S + ++ LD ++D+M S+
Sbjct: 1258 DQLSEIKTKEEEQQRLINELSAQKARL-----HTESGEFSRQ--LD-----EKDAMVSQL 1305
Query: 447 SSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAE 506
S T + ++L L EE L Q+ + LL+EQ + E
Sbjct: 1306 SRGKQAFTQQI-----EELKRQL--EEETKAKSTLAHALQSARHDCDLLREQ----YEEE 1354
Query: 507 REAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAE 566
+EAKA+ Q+G E Q K + +++ E+ E
Sbjct: 1355 QEAKAE---------------------LQRGMSKANSEVAQWRTKYETDAIQRTEELEEA 1393
Query: 567 NHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKD 626
+L Q LQDA + E + + LE+ ++R ++ V+D
Sbjct: 1394 KKKLAQRLQDAEEHVEAVNSKCASLEKTKQR----------------------LQNEVED 1431
Query: 627 VNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELES 686
+ I + + RN ++V LAE W Q+ E +A L E S
Sbjct: 1432 LMIDVERSNAACIALDKKQRNFDKV----------LAE-WKQKYEETQAELEASQKESRS 1480
Query: 687 DMEQFCKIKGYLEEELDY---RKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQ 743
+ K+K EE LD+ K+ I +L + + ++ + + +
Sbjct: 1481 LSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHE 1540
Query: 744 QEELRTAVEKLRRQMLRKSREYDCQILQERMELLQ---QAHQRIRDLEDKTDIQKR 796
+ EL+T++E+ + + +IL+ ++EL Q + ++I + +++ D KR
Sbjct: 1541 KSELQTSLEEAEASL----EHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKR 1592
Score = 66.2 bits (160), Expect = 1e-10
Identities = 133/693 (19%), Positives = 275/693 (39%), Gaps = 105/693 (15%)
Query: 128 KVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSE 187
K++ L E+ E K +E+A + +K+++E + ++Q + DL+ +
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQ----EKNDLQLQ 894
Query: 188 HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQ 247
Q+ +A++ + R IK K LE +++ T + A DE+
Sbjct: 895 VQAEADALADAE-------ERCDQLIKTK----IQLEAKIKEVT---------ERAEDEE 934
Query: 248 LFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGD 307
E +++ KR++ + CS +K I +L T+ K+E +
Sbjct: 935 -----EINAELTAKKRKL-------EDECSEL-----KKDIDDLELTLAKVEKEKHATEN 977
Query: 308 ERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITS 367
+ L + + ++ L + K L + + + + LQ E+K+ +TK +++ +++
Sbjct: 978 KVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDD 1037
Query: 368 -HPPLKKLKSL-NDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKP 425
L++ K L DL++A + E + + E T D E ++ + K
Sbjct: 1038 LEGSLEQEKKLCMDLERAKRKLEGDL---------KLAQESTMDTENDKQQLNEKLKKKE 1088
Query: 426 IKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEY 485
+ L I DE ++ + R ++ E + ++E + L++E
Sbjct: 1089 FEMSNLQGKI-EDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSREL 1147
Query: 486 QALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLE-----ATLAQKGQDS 540
+ + E+ GG A+ E + + + + +R + L+ A L +K DS
Sbjct: 1148 EEISERL----EEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADS 1203
Query: 541 HWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPP 600
V + I Q + +K+EK+++E L+ E+ D N+E + + +
Sbjct: 1204 --VAELGEQIDSLQRVKQKLEKEKSE---LKMEINDLAS--------NMETVSKAKAN-- 1248
Query: 601 FNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVL 660
F D +S ++ K+ LI +L L E + S L
Sbjct: 1249 FEKMCRTLEDQLSEIK-------TKEEEQQRLINELS--AQKARLHTESG----EFSRQL 1295
Query: 661 SLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALD---QAYMRIQ 717
+ + Q+ + A Q++ EL+ +E+ K K L L + D + Y Q
Sbjct: 1296 DEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQ 1355
Query: 718 ELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRR-QMLRKSREYDCQILQERMEL 776
E +A L + + SE Q + + ++R + L ++++ Q LQ+ E
Sbjct: 1356 EAKAELQRGMSKAN--------SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEH 1407
Query: 777 LQQAHQRIRDLEDKTDIQKRQIKDL---EEKSN 806
++ + + LE + +++DL E+SN
Sbjct: 1408 VEAVNSKCASLEKTKQRLQNEVEDLMIDVERSN 1440
Score = 33.5 bits (75), Expect = 0.81
Identities = 36/176 (20%), Positives = 74/176 (42%), Gaps = 13/176 (7%)
Query: 646 RNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKI-------KGYL 698
+N+ Q+ + + L+ AE+ Q+ + L K+ E+ E +I K L
Sbjct: 888 KNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKL 947
Query: 699 EEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQM 758
E+E K+ +D + + ++E + + V E ++ + + EK Q
Sbjct: 948 EDECSELKKDIDDLELTLAKVEKEKHAT--ENKVKNLTEEMAGLDETIAKLTKEKKALQE 1005
Query: 759 LRKSREYDCQILQERMELLQQA----HQRIRDLEDKTDIQKRQIKDLEEKSNRKHG 810
+ D Q+ ++++ L +A Q++ DLE + +K+ DLE + G
Sbjct: 1006 AHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEG 1061
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 98.6 bits (244), Expect = 2e-20
Identities = 172/868 (19%), Positives = 357/868 (41%), Gaps = 125/868 (14%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLERE------------ 50
KK ++ E L L+ D ++ D+Q ++ + K +++K E E
Sbjct: 1044 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1103
Query: 51 --KTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRD 108
K K+IRELE +++L+ L E+ +A ++ E E +T
Sbjct: 1104 AQKNNALKKIRELEGH-----ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1158
Query: 109 GEIQRLKSALCALRDGSSDKVRTALTIEAR------EEARKLFDTERLKLLQEIADLKTA 162
+ + L A R+ ++ AL E R +E R+ +L +++ K A
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1218
Query: 163 KKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFS 222
K +D+ + + + AG+LR Q+ QE K K + E ++ L + +R
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK-KLEAQVQELQSKCSDGERARAE 1277
Query: 223 LEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLR 282
L + V KLQ + E++ L + ++ + + D E L+
Sbjct: 1278 LNDK-------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL-----LQ 1325
Query: 283 RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
++ ++ +R+LE+ L D+ +E ++ + E+ L + K+ +
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 343 SLQRMEEKLKAVTKE----NSEMREKITSHPPLKKLKS-----LNDL--DQANEEQETEF 391
+++ +EE K KE + EK ++ L+K K+ L+DL D N+ Q
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445
Query: 392 LKLQ-------VIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDS 444
L+ + + E++NI + +R++ + + + L+ + E+
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL--E 1503
Query: 445 ETSSMASFRTDRTPATPDD------DLDESLAA-----EESELRFRQLTKEYQALQRAYA 493
T+ M + ++ DD +L++S A EE + + +L E QA + A
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563
Query: 494 LLQ---EQTGGIIDAEREAKAQE------QLQAEVLRYKAKIEDLE-----ATLAQKGQD 539
L+ + G + + +A+ ++ QLQ ++ Y+ ++ED A A+K +
Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Query: 540 SHWVEDKQL----FIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERE 595
++D +L IK +E ++++ K +A+ Q+EL+DAR + + +E E
Sbjct: 1624 GD-LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF---ATAKENE 1679
Query: 596 RRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQ 655
+++ + + ++A + KQ D+ +E++A
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAE--------------RARKQADL--------EKEELAEEL 1717
Query: 656 ASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMR 715
AS++ ++ + L ++ +LE ++E+ +G +E D ++A QA
Sbjct: 1718 ASSLSGR-----NALQDEKRRLEARIAQLEEELEEE---QGNMEAMSDRVRKATQQAEQL 1769
Query: 716 IQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERME 775
EL A + E+ + E+Q +ELR+ + ++ + K + + + +
Sbjct: 1770 SNELATERSTAQKNESARQ----QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 776 LLQQAHQRIRDLEDKTDIQKRQIKDLEE 803
L +Q Q R+ + T K++ K L+E
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Score = 92.8 bits (229), Expect = 1e-18
Identities = 174/925 (18%), Positives = 365/925 (39%), Gaps = 192/925 (20%)
Query: 19 LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELE---------------- 62
LQA + + ++ D++ +L +E++ KL+ EK +I++LE
Sbjct: 941 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1000
Query: 63 ----------------------------QRKHTVLVTELKAKL--HEEKMKELQAVRENL 92
+ KH +++EL+ +L E+ +EL+ ++ L
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 93 ------------------------IKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDK 128
+ + E+E+ + D EI + +AL +R+
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 129 VRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKA------- 181
+++ AR + ++ L +E+ LKT ++++ L + +++A
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKT---ELEDTLDSTATQQELRAKREQEVT 1177
Query: 182 ---GDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQ 238
L E +SH+ + +++ + + + L ++++ R +L+K +T L+
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT-------LE 1230
Query: 239 LQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKL 298
+ L +L ++ +A+ + K+++ + + CS + R AELN + KL
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR-----AELNDKVHKL 1285
Query: 299 EDR----NTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDE---LMVSLQRMEEK- 350
++ +L + + +K ++ L + + L + + + L+++EE+
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 351 --LKAVTKENSEMREKITSH---------PPLKKLKSLNDLDQANEEQETEFLKLQVIEQ 399
L+ E E ++ + H KKL+ +A EE + F
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF-------- 1397
Query: 400 QNIIDELTRD-REKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTP 458
Q I+ LT+ EK K ++ +++ + D + D + D+
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 459 ATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAE 518
A + ++ A E KE +AL A AL E +A+E+L+
Sbjct: 1458 A-EEKNISSKYADERDRAEAEAREKETKALSLARAL-----------EEALEAKEELERT 1505
Query: 519 VLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDAR 578
KA++EDL ++ G++ H +E K + L ++E+ + + L+ ELQ
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELE------KSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 579 DQNELLEF----------RNLEL--EERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKD 626
D LE R+L+ E+ E + Q+H + + +
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1619
Query: 627 VNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAAL--------- 677
+ +K L++ D+ EE AI Q + + + + +++E A A+
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREE--AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1677
Query: 678 -HQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFG 736
+K LE+D+ Q L+E+L ++A QA + +EL L ++L ++
Sbjct: 1678 NEKKAKSLEADLMQ-------LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ-- 1728
Query: 737 ELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERM-ELLQQAHQRIRDL-EDKTDIQ 794
EK++ E R A +L ++ + + + + + +R+ + QQA Q +L +++ Q
Sbjct: 1729 ---DEKRRLEARIA--QLEEEL--EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 795 K---------RQIKDLEEKSNRKHG 810
K RQ K+L K + G
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEG 1806
Score = 84.0 bits (206), Expect = 5e-16
Identities = 146/689 (21%), Positives = 277/689 (40%), Gaps = 85/689 (12%)
Query: 128 KVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSE 187
KV+ L + +EE + + E K + + K++++ S + + + L++E
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 188 HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQ 247
+ + EA E RL + + + I+ +E LE + Q+LQ +++ + +Q
Sbjct: 900 TELYAEA--------EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951
Query: 248 LFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAEL--NATIRKLEDRNTLL 305
+ D E + R + ++ ++ A I+KLED ++
Sbjct: 952 ML---------------------DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990
Query: 306 GDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKI 365
D+ N+L K K L +R +L +L EEK K +TK ++ I
Sbjct: 991 DDQNNKLSK--------------ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036
Query: 366 TS-HPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSK 424
+ LKK + QE E LK ++ + E D + I K + +
Sbjct: 1037 SELEVRLKK--------EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK- 1087
Query: 425 PIKRPVLDPFIGYDEDSMDSETSSMASFR-TDRTPATPDDDLD-ESLAAEESELRFRQLT 482
K L + +D + + +++ R + + +DLD E A ++E + R L
Sbjct: 1088 --KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 483 KEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHW 542
+E +AL+ E T ++E +A+ + + VL+ KA E+ + AQ
Sbjct: 1146 EELEALKTEL----EDTLDSTATQQELRAKREQEVTVLK-KALDEETRSHEAQV------ 1194
Query: 543 VEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELL--EFRNLELEERERRSPP 600
E +Q + +EL E++E+ + L + Q +N L E R L ++E
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254
Query: 601 FNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQL--DILGDNGNLRNEEQVAIIQAST 658
L+ V LQ C + D + +L ++ G L E AI A
Sbjct: 1255 KKLEAQ-----VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 659 VLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQE 718
V SL+ + E + QK + + + + Q + + L+++LD +A I
Sbjct: 1310 VASLSSQLQDTQELLQEETRQK-LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQ 778
L L ++ ++ E+ ++ + +E L +Q K+ YD L++ LQ
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD--KLEKTKNRLQ 1426
Query: 779 QAHQRIRDLEDKTDIQKRQIKDLEEKSNR 807
Q + DL D Q++ + +LE+K +
Sbjct: 1427 ---QELDDLVVDLDNQRQLVSNLEKKQRK 1452
Score = 82.4 bits (202), Expect = 2e-15
Identities = 176/809 (21%), Positives = 323/809 (39%), Gaps = 143/809 (17%)
Query: 72 ELKAKLHE-EKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVR 130
E++AK E +K KE Q EN +K+ EQ+ S+ + ++ ++L++ + +VR
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 131 TA--------------LTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQA 176
A +E E+ + ER K+ Q++ DL+ ++ +EA +Q
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQL 971
Query: 177 DKI----KAGDLRSEHQSHQEAISKIKWESERDIRRLMDE-IKAKDRIIFSLEKELETQT 231
+K+ K L E + +K+ E R+L++E I + E++ + T
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKE-----RKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 232 GYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAEL 291
K + L+ +L +++ + KR++ G A D E + DL Q +IAEL
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA--DL---QAQIAEL 1081
Query: 292 NATIRKLEDR----NTLLGDE---RNELLKRVRETEKQCKPLLE--------RNKCLAKR 336
+ K E+ L DE +N LK++RE E L E RNK ++
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 337 NDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQV 396
D + E+L+A+ E + + + L+ A EQE LK
Sbjct: 1142 RD--------LGEELEALKTELEDTLDSTATQQELR----------AKREQEVTVLK--- 1180
Query: 397 IEQQNIIDELTRDREKLIR--RRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRT 454
+DE TR E ++ R+KH ++ +E + E A
Sbjct: 1181 ----KALDEETRSHEAQVQEMRQKHAQA--------------VEELTEQLEQFKRAKANL 1222
Query: 455 DRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQ-- 512
D+ T + + + LA E L + E++ ++ A +QE D ER A+A+
Sbjct: 1223 DKNKQTLEKE-NADLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGER-ARAELN 1279
Query: 513 ---EQLQAEVLRYKAKIEDLEATLAQKGQD----SHWVEDKQLFI----KRNQELLEKIE 561
+LQ EV + + E + +D S ++D Q + ++ + K+
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 562 KQEAENHRLQQELQDARDQNELLEFR----NLELEERERRSPPFNLQIHPFSDGVSALQ- 616
+ E E + LQ +L + + + LE N++L + +++ F + +G Q
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399
Query: 617 --------------IYCMKEGVKD---VNIPDLIKQLDILGD-NGNLRNEEQVAIIQAST 658
Y E K+ + DL+ LD NL +++ +
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Query: 659 VLSLAEKWIQQIEGAEAALHQ---KMMELESDMEQFCKIKGYLEE-------ELDYRKQA 708
+++ K+ + + AEA + K + L +E+ + K LE E++ +
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519
Query: 709 LDQAYMRIQELEAT--LYNALQQETVIKFGELLSEKQQEE-----LRTAVEKLRRQMLRK 761
D + ELE + +E + EL E Q E L ++ L+ Q R
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579
Query: 762 SREYDCQILQERMELLQQAHQRIRDLEDK 790
+ D Q ++R +L +Q H+ +LED+
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDE 1608
Score = 77.8 bits (190), Expect = 4e-14
Identities = 142/698 (20%), Positives = 280/698 (40%), Gaps = 110/698 (15%)
Query: 147 TERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDI 206
TE LLQE +T E + + A K + ++ E ++ E E E
Sbjct: 886 TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE-------EEEDRG 938
Query: 207 RRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQK-------EALDEQLFLVKEAECNMS 259
++L E K + + LE++LE + QKLQL+K + L++++ ++ + +S
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998
Query: 260 SPKREIPGRAGDGSEHCSSPDLR---------RNQKRIAELNATIRKLEDRNTLLGDERN 310
++ + R D + + + + + +++ I+EL ++K E R
Sbjct: 999 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE-------KSRQ 1051
Query: 311 ELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLK-AVTKENSEMREKITSHP 369
EL K R+ E E+ L + EL + L + EE+L+ A+ + + E+ +K +
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK---NN 1108
Query: 370 PLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRP 429
LKK++ L + + Q +D R K ++++ +
Sbjct: 1109 ALKKIRELEG---------------HISDLQEDLDSERAARNKAEKQKRDLGEELEALKT 1153
Query: 430 VLDPFIGYDEDSMDSETSSMASFRTDRTPATP--DDDLDESLAAEESELRFRQLTKEYQA 487
L ED++DS T++ R R LDE + E+++ Q
Sbjct: 1154 EL-------EDTLDS-TATQQELRAKREQEVTVLKKALDEETRSHEAQV---------QE 1196
Query: 488 LQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQ 547
+++ +A E+ ++ + AKA + L + + DL L GQ VE K+
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL--EKENADLAGELRVLGQAKQEVEHKK 1254
Query: 548 LFIKRNQELLEKIEKQEAENHRLQQELQDA--RDQNELLEFRNLELEERERRSPPFNLQI 605
K+ + +++++ + ++ R + EL D + QNE+ + L E E ++ +
Sbjct: 1255 ---KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-LNEAEGKAIKLAKDV 1310
Query: 606 HPFSDGVSALQIYCMKEGVKDVNIPDLIKQL--------DILGDNGNLRNEEQVAIIQAS 657
S + Q +E + +N+ ++QL D L + + + I +
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 658 TVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFC--------------KIKGYLEEELD 703
LS ++K +Q AL + + ++E K K L++ELD
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430
Query: 704 YRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSR 763
LD + LE + KF +LL+E++ + A E+ R + + +
Sbjct: 1431 DLVVDLDNQRQLVSNLE---------KKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 764 EYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDL 801
E L +E +A + +LE + K +++DL
Sbjct: 1482 ETKALSLARALE---EALEAKEELERTNKMLKAEMEDL 1516
Score = 73.6 bits (179), Expect = 7e-13
Identities = 136/696 (19%), Positives = 267/696 (38%), Gaps = 122/696 (17%)
Query: 7 NKGEKPEALIVALQA-------ANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIR 59
+K +K EA + LQ+ A +L K+ +Q E+ +++ E + + AK +
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311
Query: 60 ELE---QRKHTVLVTELKAKLH-EEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLK 115
L Q +L E + KL+ K+++L+ R +L Q ++EM + + +
Sbjct: 1312 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE----RHIS 1367
Query: 116 SALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIAD-------LKTAKKQVDE 168
+ L D A T+EA EE +K F E L Q+ + L+ K ++ +
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 169 ALSNMIQADKIKAGDLRSEHQSHQEAISKI---------KWESERD-------------- 205
L +++ D L S + Q ++ K+ ERD
Sbjct: 1428 ELDDLV-VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 206 --IRRLMDEIKAKDRI------------------------IFSLEKELETQTGYVQKLQL 239
R L + ++AK+ + + LEK +++++
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 240 QKEALDEQLFLVKEA----ECNMSSPK----REIPGRAGDGSE---------HCSSPDLR 282
Q E L+++L ++A E NM + K R++ R E H +L
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Query: 283 RNQKRIAELNATIRKLEDRNT---LLGDE----RNELLKRVRETEKQCKPLLERNKCLAK 335
+K+ A A +KLE L D R E +K++R+ + Q K +
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666
Query: 336 RNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQ 395
DE+ + + E+K K++ + +++E + + +K L + A E +
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS------ 1720
Query: 396 VIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTD 455
+ +N + + R E I + + + + + + ++ +A T+
Sbjct: 1721 -LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA---TE 1776
Query: 456 RTPATPDDDLDESLAAEESELRFR----------QLTKEYQALQRAYALLQEQTGGIIDA 505
R+ A ++ + L + ELR + + AL+ A L+EQ +A
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ--EA 1834
Query: 506 EREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQE- 564
+ A + L+ + + K + +E Q E +K+ + LE+ E++
Sbjct: 1835 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1894
Query: 565 ---AENHRLQQELQDARDQNELLEFRNLELEERERR 597
A +LQ+EL +A + NE + L+ + RR
Sbjct: 1895 RINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1930
Score = 38.1 bits (87), Expect = 0.033
Identities = 73/343 (21%), Positives = 144/343 (41%), Gaps = 59/343 (17%)
Query: 472 EESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEA 531
EE +L+ + +QA+ R Y + + AK Q+QL A K+
Sbjct: 780 EERDLKITDVIMAFQAMCRGY----------LARKAFAKRQQQLTA------MKVIQRNC 823
Query: 532 TLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLEL 591
K ++ W +LF K L ++ +QE E + ELQ +++ + E EL
Sbjct: 824 AAYLKLRNWQWW---RLFTKVKPLL--QVTRQEEEMQAKEDELQKTKERQQKAE---NEL 875
Query: 592 EERERRSPPFNLQIHPFSDGVSA-LQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQ 650
+E E++ + + + + A ++Y E ++ V + ++L+ + R EE+
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR-VRLAAKKQELEEILHEMEARLEEE 934
Query: 651 VAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALD 710
E QQ++ + Q+M++LE +E EEE +K L+
Sbjct: 935 -------------EDRGQQLQAERKKMAQQMLDLEEQLE---------EEEAARQKLQLE 972
Query: 711 Q--AYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAV---EKLRRQMLRKSREY 765
+ A +I++LE + Q + L E++ +L T + E+ + + + ++
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 766 DCQI--LQERMELLQQAHQRI----RDLEDKTDIQKRQIKDLE 802
+ I L+ R++ +++ Q + R LE QI DL+
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQ 1075
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 98.6 bits (244), Expect = 2e-20
Identities = 172/868 (19%), Positives = 357/868 (41%), Gaps = 125/868 (14%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLERE------------ 50
KK ++ E L L+ D ++ D+Q ++ + K +++K E E
Sbjct: 1051 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1110
Query: 51 --KTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRD 108
K K+IRELE +++L+ L E+ +A ++ E E +T
Sbjct: 1111 AQKNNALKKIRELEGH-----ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1165
Query: 109 GEIQRLKSALCALRDGSSDKVRTALTIEAR------EEARKLFDTERLKLLQEIADLKTA 162
+ + L A R+ ++ AL E R +E R+ +L +++ K A
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1225
Query: 163 KKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFS 222
K +D+ + + + AG+LR Q+ QE K K + E ++ L + +R
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK-KLEAQVQELQSKCSDGERARAE 1284
Query: 223 LEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLR 282
L + V KLQ + E++ L + ++ + + D E L+
Sbjct: 1285 LNDK-------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL-----LQ 1332
Query: 283 RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
++ ++ +R+LE+ L D+ +E ++ + E+ L + K+ +
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 343 SLQRMEEKLKAVTKE----NSEMREKITSHPPLKKLKS-----LNDL--DQANEEQETEF 391
+++ +EE K KE + EK ++ L+K K+ L+DL D N+ Q
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452
Query: 392 LKLQ-------VIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDS 444
L+ + + E++NI + +R++ + + + L+ + E+
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL--E 1510
Query: 445 ETSSMASFRTDRTPATPDD------DLDESLAA-----EESELRFRQLTKEYQALQRAYA 493
T+ M + ++ DD +L++S A EE + + +L E QA + A
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570
Query: 494 LLQ---EQTGGIIDAEREAKAQE------QLQAEVLRYKAKIEDLE-----ATLAQKGQD 539
L+ + G + + +A+ ++ QLQ ++ Y+ ++ED A A+K +
Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Query: 540 SHWVEDKQL----FIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERE 595
++D +L IK +E ++++ K +A+ Q+EL+DAR + + +E E
Sbjct: 1631 GD-LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF---ATAKENE 1686
Query: 596 RRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQ 655
+++ + + ++A + KQ D+ +E++A
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAE--------------RARKQADL--------EKEELAEEL 1724
Query: 656 ASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMR 715
AS++ ++ + L ++ +LE ++E+ +G +E D ++A QA
Sbjct: 1725 ASSLSGR-----NALQDEKRRLEARIAQLEEELEEE---QGNMEAMSDRVRKATQQAEQL 1776
Query: 716 IQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERME 775
EL A + E+ + E+Q +ELR+ + ++ + K + + + +
Sbjct: 1777 SNELATERSTAQKNESARQ----QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 776 LLQQAHQRIRDLEDKTDIQKRQIKDLEE 803
L +Q Q R+ + T K++ K L+E
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Score = 92.8 bits (229), Expect = 1e-18
Identities = 174/925 (18%), Positives = 365/925 (39%), Gaps = 192/925 (20%)
Query: 19 LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELE---------------- 62
LQA + + ++ D++ +L +E++ KL+ EK +I++LE
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1007
Query: 63 ----------------------------QRKHTVLVTELKAKL--HEEKMKELQAVRENL 92
+ KH +++EL+ +L E+ +EL+ ++ L
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 93 ------------------------IKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDK 128
+ + E+E+ + D EI + +AL +R+
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 129 VRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKA------- 181
+++ AR + ++ L +E+ LKT ++++ L + +++A
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKT---ELEDTLDSTATQQELRAKREQEVT 1184
Query: 182 ---GDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQ 238
L E +SH+ + +++ + + + L ++++ R +L+K +T L+
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT-------LE 1237
Query: 239 LQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKL 298
+ L +L ++ +A+ + K+++ + + CS + R AELN + KL
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR-----AELNDKVHKL 1292
Query: 299 EDR----NTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDE---LMVSLQRMEEK- 350
++ +L + + +K ++ L + + L + + + L+++EE+
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 351 --LKAVTKENSEMREKITSH---------PPLKKLKSLNDLDQANEEQETEFLKLQVIEQ 399
L+ E E ++ + H KKL+ +A EE + F
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF-------- 1404
Query: 400 QNIIDELTRD-REKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTP 458
Q I+ LT+ EK K ++ +++ + D + D + D+
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 459 ATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAE 518
A + ++ A E KE +AL A AL E +A+E+L+
Sbjct: 1465 A-EEKNISSKYADERDRAEAEAREKETKALSLARAL-----------EEALEAKEELERT 1512
Query: 519 VLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDAR 578
KA++EDL ++ G++ H +E K + L ++E+ + + L+ ELQ
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELE------KSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 579 DQNELLEF----------RNLEL--EERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKD 626
D LE R+L+ E+ E + Q+H + + +
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1626
Query: 627 VNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAAL--------- 677
+ +K L++ D+ EE AI Q + + + + +++E A A+
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREE--AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1684
Query: 678 -HQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFG 736
+K LE+D+ Q L+E+L ++A QA + +EL L ++L ++
Sbjct: 1685 NEKKAKSLEADLMQ-------LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ-- 1735
Query: 737 ELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERM-ELLQQAHQRIRDL-EDKTDIQ 794
EK++ E R A +L ++ + + + + + +R+ + QQA Q +L +++ Q
Sbjct: 1736 ---DEKRRLEARIA--QLEEEL--EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 795 K---------RQIKDLEEKSNRKHG 810
K RQ K+L K + G
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEG 1813
Score = 84.0 bits (206), Expect = 5e-16
Identities = 146/689 (21%), Positives = 277/689 (40%), Gaps = 85/689 (12%)
Query: 128 KVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSE 187
KV+ L + +EE + + E K + + K++++ S + + + L++E
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 188 HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQ 247
+ + EA E RL + + + I+ +E LE + Q+LQ +++ + +Q
Sbjct: 907 TELYAEA--------EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958
Query: 248 LFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAEL--NATIRKLEDRNTLL 305
+ D E + R + ++ ++ A I+KLED ++
Sbjct: 959 ML---------------------DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997
Query: 306 GDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKI 365
D+ N+L K K L +R +L +L EEK K +TK ++ I
Sbjct: 998 DDQNNKLSK--------------ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043
Query: 366 TS-HPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSK 424
+ LKK + QE E LK ++ + E D + I K + +
Sbjct: 1044 SELEVRLKK--------EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK- 1094
Query: 425 PIKRPVLDPFIGYDEDSMDSETSSMASFR-TDRTPATPDDDLD-ESLAAEESELRFRQLT 482
K L + +D + + +++ R + + +DLD E A ++E + R L
Sbjct: 1095 --KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 483 KEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHW 542
+E +AL+ E T ++E +A+ + + VL+ KA E+ + AQ
Sbjct: 1153 EELEALKTEL----EDTLDSTATQQELRAKREQEVTVLK-KALDEETRSHEAQV------ 1201
Query: 543 VEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELL--EFRNLELEERERRSPP 600
E +Q + +EL E++E+ + L + Q +N L E R L ++E
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261
Query: 601 FNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQL--DILGDNGNLRNEEQVAIIQAST 658
L+ V LQ C + D + +L ++ G L E AI A
Sbjct: 1262 KKLEAQ-----VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 659 VLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQE 718
V SL+ + E + QK + + + + Q + + L+++LD +A I
Sbjct: 1317 VASLSSQLQDTQELLQEETRQK-LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQ 778
L L ++ ++ E+ ++ + +E L +Q K+ YD L++ LQ
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD--KLEKTKNRLQ 1433
Query: 779 QAHQRIRDLEDKTDIQKRQIKDLEEKSNR 807
Q + DL D Q++ + +LE+K +
Sbjct: 1434 ---QELDDLVVDLDNQRQLVSNLEKKQRK 1459
Score = 82.4 bits (202), Expect = 2e-15
Identities = 176/809 (21%), Positives = 323/809 (39%), Gaps = 143/809 (17%)
Query: 72 ELKAKLHE-EKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVR 130
E++AK E +K KE Q EN +K+ EQ+ S+ + ++ ++L++ + +VR
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 131 TA--------------LTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQA 176
A +E E+ + ER K+ Q++ DL+ ++ +EA +Q
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQL 978
Query: 177 DKI----KAGDLRSEHQSHQEAISKIKWESERDIRRLMDE-IKAKDRIIFSLEKELETQT 231
+K+ K L E + +K+ E R+L++E I + E++ + T
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKE-----RKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 232 GYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAEL 291
K + L+ +L +++ + KR++ G A D E + DL Q +IAEL
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA--DL---QAQIAEL 1088
Query: 292 NATIRKLEDR----NTLLGDE---RNELLKRVRETEKQCKPLLE--------RNKCLAKR 336
+ K E+ L DE +N LK++RE E L E RNK ++
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 337 NDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQV 396
D + E+L+A+ E + + + L+ A EQE LK
Sbjct: 1149 RD--------LGEELEALKTELEDTLDSTATQQELR----------AKREQEVTVLK--- 1187
Query: 397 IEQQNIIDELTRDREKLIR--RRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRT 454
+DE TR E ++ R+KH ++ +E + E A
Sbjct: 1188 ----KALDEETRSHEAQVQEMRQKHAQA--------------VEELTEQLEQFKRAKANL 1229
Query: 455 DRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQ-- 512
D+ T + + + LA E L + E++ ++ A +QE D ER A+A+
Sbjct: 1230 DKNKQTLEKE-NADLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGER-ARAELN 1286
Query: 513 ---EQLQAEVLRYKAKIEDLEATLAQKGQD----SHWVEDKQLFI----KRNQELLEKIE 561
+LQ EV + + E + +D S ++D Q + ++ + K+
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 562 KQEAENHRLQQELQDARDQNELLEFR----NLELEERERRSPPFNLQIHPFSDGVSALQ- 616
+ E E + LQ +L + + + LE N++L + +++ F + +G Q
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406
Query: 617 --------------IYCMKEGVKD---VNIPDLIKQLDILGD-NGNLRNEEQVAIIQAST 658
Y E K+ + DL+ LD NL +++ +
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 659 VLSLAEKWIQQIEGAEAALHQ---KMMELESDMEQFCKIKGYLEE-------ELDYRKQA 708
+++ K+ + + AEA + K + L +E+ + K LE E++ +
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526
Query: 709 LDQAYMRIQELEAT--LYNALQQETVIKFGELLSEKQQEE-----LRTAVEKLRRQMLRK 761
D + ELE + +E + EL E Q E L ++ L+ Q R
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586
Query: 762 SREYDCQILQERMELLQQAHQRIRDLEDK 790
+ D Q ++R +L +Q H+ +LED+
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDE 1615
Score = 77.8 bits (190), Expect = 4e-14
Identities = 142/698 (20%), Positives = 280/698 (40%), Gaps = 110/698 (15%)
Query: 147 TERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDI 206
TE LLQE +T E + + A K + ++ E ++ E E E
Sbjct: 893 TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE-------EEEDRG 945
Query: 207 RRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQK-------EALDEQLFLVKEAECNMS 259
++L E K + + LE++LE + QKLQL+K + L++++ ++ + +S
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005
Query: 260 SPKREIPGRAGDGSEHCSSPDLR---------RNQKRIAELNATIRKLEDRNTLLGDERN 310
++ + R D + + + + + +++ I+EL ++K E R
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE-------KSRQ 1058
Query: 311 ELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLK-AVTKENSEMREKITSHP 369
EL K R+ E E+ L + EL + L + EE+L+ A+ + + E+ +K +
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK---NN 1115
Query: 370 PLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRP 429
LKK++ L + + Q +D R K ++++ +
Sbjct: 1116 ALKKIRELEG---------------HISDLQEDLDSERAARNKAEKQKRDLGEELEALKT 1160
Query: 430 VLDPFIGYDEDSMDSETSSMASFRTDRTPATP--DDDLDESLAAEESELRFRQLTKEYQA 487
L ED++DS T++ R R LDE + E+++ Q
Sbjct: 1161 EL-------EDTLDS-TATQQELRAKREQEVTVLKKALDEETRSHEAQV---------QE 1203
Query: 488 LQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQ 547
+++ +A E+ ++ + AKA + L + + DL L GQ VE K+
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL--EKENADLAGELRVLGQAKQEVEHKK 1261
Query: 548 LFIKRNQELLEKIEKQEAENHRLQQELQDA--RDQNELLEFRNLELEERERRSPPFNLQI 605
K+ + +++++ + ++ R + EL D + QNE+ + L E E ++ +
Sbjct: 1262 ---KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-LNEAEGKAIKLAKDV 1317
Query: 606 HPFSDGVSALQIYCMKEGVKDVNIPDLIKQL--------DILGDNGNLRNEEQVAIIQAS 657
S + Q +E + +N+ ++QL D L + + + I +
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 658 TVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFC--------------KIKGYLEEELD 703
LS ++K +Q AL + + ++E K K L++ELD
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437
Query: 704 YRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSR 763
LD + LE + KF +LL+E++ + A E+ R + + +
Sbjct: 1438 DLVVDLDNQRQLVSNLE---------KKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 764 EYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDL 801
E L +E +A + +LE + K +++DL
Sbjct: 1489 ETKALSLARALE---EALEAKEELERTNKMLKAEMEDL 1523
Score = 73.6 bits (179), Expect = 7e-13
Identities = 136/696 (19%), Positives = 267/696 (38%), Gaps = 122/696 (17%)
Query: 7 NKGEKPEALIVALQA-------ANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIR 59
+K +K EA + LQ+ A +L K+ +Q E+ +++ E + + AK +
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318
Query: 60 ELE---QRKHTVLVTELKAKLH-EEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLK 115
L Q +L E + KL+ K+++L+ R +L Q ++EM + + +
Sbjct: 1319 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE----RHIS 1374
Query: 116 SALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIAD-------LKTAKKQVDE 168
+ L D A T+EA EE +K F E L Q+ + L+ K ++ +
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 169 ALSNMIQADKIKAGDLRSEHQSHQEAISKI---------KWESERD-------------- 205
L +++ D L S + Q ++ K+ ERD
Sbjct: 1435 ELDDLV-VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 206 --IRRLMDEIKAKDRI------------------------IFSLEKELETQTGYVQKLQL 239
R L + ++AK+ + + LEK +++++
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 240 QKEALDEQLFLVKEA----ECNMSSPK----REIPGRAGDGSE---------HCSSPDLR 282
Q E L+++L ++A E NM + K R++ R E H +L
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Query: 283 RNQKRIAELNATIRKLEDRNT---LLGDE----RNELLKRVRETEKQCKPLLERNKCLAK 335
+K+ A A +KLE L D R E +K++R+ + Q K +
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1673
Query: 336 RNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQ 395
DE+ + + E+K K++ + +++E + + +K L + A E +
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS------ 1727
Query: 396 VIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTD 455
+ +N + + R E I + + + + + + ++ +A T+
Sbjct: 1728 -LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA---TE 1783
Query: 456 RTPATPDDDLDESLAAEESELRFR----------QLTKEYQALQRAYALLQEQTGGIIDA 505
R+ A ++ + L + ELR + + AL+ A L+EQ +A
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ--EA 1841
Query: 506 EREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQE- 564
+ A + L+ + + K + +E Q E +K+ + LE+ E++
Sbjct: 1842 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1901
Query: 565 ---AENHRLQQELQDARDQNELLEFRNLELEERERR 597
A +LQ+EL +A + NE + L+ + RR
Sbjct: 1902 RINANRRKLQRELDEATESNEAMGREVNALKSKLRR 1937
Score = 38.1 bits (87), Expect = 0.033
Identities = 73/343 (21%), Positives = 144/343 (41%), Gaps = 59/343 (17%)
Query: 472 EESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEA 531
EE +L+ + +QA+ R Y + + AK Q+QL A K+
Sbjct: 787 EERDLKITDVIMAFQAMCRGY----------LARKAFAKRQQQLTA------MKVIQRNC 830
Query: 532 TLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLEL 591
K ++ W +LF K L ++ +QE E + ELQ +++ + E EL
Sbjct: 831 AAYLKLRNWQWW---RLFTKVKPLL--QVTRQEEEMQAKEDELQKTKERQQKAE---NEL 882
Query: 592 EERERRSPPFNLQIHPFSDGVSA-LQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQ 650
+E E++ + + + + A ++Y E ++ V + ++L+ + R EE+
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR-VRLAAKKQELEEILHEMEARLEEE 941
Query: 651 VAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALD 710
E QQ++ + Q+M++LE +E EEE +K L+
Sbjct: 942 -------------EDRGQQLQAERKKMAQQMLDLEEQLE---------EEEAARQKLQLE 979
Query: 711 Q--AYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAV---EKLRRQMLRKSREY 765
+ A +I++LE + Q + L E++ +L T + E+ + + + ++
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 766 DCQI--LQERMELLQQAHQRI----RDLEDKTDIQKRQIKDLE 802
+ I L+ R++ +++ Q + R LE QI DL+
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQ 1082
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 98.6 bits (244), Expect = 2e-20
Identities = 172/868 (19%), Positives = 357/868 (41%), Gaps = 125/868 (14%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLERE------------ 50
KK ++ E L L+ D ++ D+Q ++ + K +++K E E
Sbjct: 1051 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1110
Query: 51 --KTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRD 108
K K+IRELE +++L+ L E+ +A ++ E E +T
Sbjct: 1111 AQKNNALKKIRELEGH-----ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1165
Query: 109 GEIQRLKSALCALRDGSSDKVRTALTIEAR------EEARKLFDTERLKLLQEIADLKTA 162
+ + L A R+ ++ AL E R +E R+ +L +++ K A
Sbjct: 1166 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1225
Query: 163 KKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFS 222
K +D+ + + + AG+LR Q+ QE K K + E ++ L + +R
Sbjct: 1226 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK-KLEAQVQELQSKCSDGERARAE 1284
Query: 223 LEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLR 282
L + V KLQ + E++ L + ++ + + D E L+
Sbjct: 1285 LNDK-------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL-----LQ 1332
Query: 283 RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
++ ++ +R+LE+ L D+ +E ++ + E+ L + K+ +
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 343 SLQRMEEKLKAVTKE----NSEMREKITSHPPLKKLKS-----LNDL--DQANEEQETEF 391
+++ +EE K KE + EK ++ L+K K+ L+DL D N+ Q
Sbjct: 1393 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1452
Query: 392 LKLQ-------VIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDS 444
L+ + + E++NI + +R++ + + + L+ + E+
Sbjct: 1453 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL--E 1510
Query: 445 ETSSMASFRTDRTPATPDD------DLDESLAA-----EESELRFRQLTKEYQALQRAYA 493
T+ M + ++ DD +L++S A EE + + +L E QA + A
Sbjct: 1511 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1570
Query: 494 LLQ---EQTGGIIDAEREAKAQE------QLQAEVLRYKAKIEDLE-----ATLAQKGQD 539
L+ + G + + +A+ ++ QLQ ++ Y+ ++ED A A+K +
Sbjct: 1571 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1630
Query: 540 SHWVEDKQL----FIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERE 595
++D +L IK +E ++++ K +A+ Q+EL+DAR + + +E E
Sbjct: 1631 GD-LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF---ATAKENE 1686
Query: 596 RRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQ 655
+++ + + ++A + KQ D+ +E++A
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAE--------------RARKQADL--------EKEELAEEL 1724
Query: 656 ASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMR 715
AS++ ++ + L ++ +LE ++E+ +G +E D ++A QA
Sbjct: 1725 ASSLSGR-----NALQDEKRRLEARIAQLEEELEEE---QGNMEAMSDRVRKATQQAEQL 1776
Query: 716 IQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERME 775
EL A + E+ + E+Q +ELR+ + ++ + K + + + +
Sbjct: 1777 SNELATERSTAQKNESARQ----QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 776 LLQQAHQRIRDLEDKTDIQKRQIKDLEE 803
L +Q Q R+ + T K++ K L+E
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Score = 92.8 bits (229), Expect = 1e-18
Identities = 174/925 (18%), Positives = 365/925 (39%), Gaps = 192/925 (20%)
Query: 19 LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELE---------------- 62
LQA + + ++ D++ +L +E++ KL+ EK +I++LE
Sbjct: 948 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1007
Query: 63 ----------------------------QRKHTVLVTELKAKL--HEEKMKELQAVRENL 92
+ KH +++EL+ +L E+ +EL+ ++ L
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 93 ------------------------IKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDK 128
+ + E+E+ + D EI + +AL +R+
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 129 VRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKA------- 181
+++ AR + ++ L +E+ LKT ++++ L + +++A
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKT---ELEDTLDSTATQQELRAKREQEVT 1184
Query: 182 ---GDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQ 238
L E +SH+ + +++ + + + L ++++ R +L+K +T L+
Sbjct: 1185 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT-------LE 1237
Query: 239 LQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKL 298
+ L +L ++ +A+ + K+++ + + CS + R AELN + KL
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR-----AELNDKVHKL 1292
Query: 299 EDR----NTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDE---LMVSLQRMEEK- 350
++ +L + + +K ++ L + + L + + + L+++EE+
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 351 --LKAVTKENSEMREKITSH---------PPLKKLKSLNDLDQANEEQETEFLKLQVIEQ 399
L+ E E ++ + H KKL+ +A EE + F
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF-------- 1404
Query: 400 QNIIDELTRD-REKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTP 458
Q I+ LT+ EK K ++ +++ + D + D + D+
Sbjct: 1405 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1464
Query: 459 ATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAE 518
A + ++ A E KE +AL A AL E +A+E+L+
Sbjct: 1465 A-EEKNISSKYADERDRAEAEAREKETKALSLARAL-----------EEALEAKEELERT 1512
Query: 519 VLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDAR 578
KA++EDL ++ G++ H +E K + L ++E+ + + L+ ELQ
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELE------KSKRALETQMEEMKTQLEELEDELQATE 1566
Query: 579 DQNELLEF----------RNLEL--EERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKD 626
D LE R+L+ E+ E + Q+H + + +
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1626
Query: 627 VNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAAL--------- 677
+ +K L++ D+ EE AI Q + + + + +++E A A+
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREE--AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1684
Query: 678 -HQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFG 736
+K LE+D+ Q L+E+L ++A QA + +EL L ++L ++
Sbjct: 1685 NEKKAKSLEADLMQ-------LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ-- 1735
Query: 737 ELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERM-ELLQQAHQRIRDL-EDKTDIQ 794
EK++ E R A +L ++ + + + + + +R+ + QQA Q +L +++ Q
Sbjct: 1736 ---DEKRRLEARIA--QLEEEL--EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 795 K---------RQIKDLEEKSNRKHG 810
K RQ K+L K + G
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEG 1813
Score = 84.0 bits (206), Expect = 5e-16
Identities = 146/689 (21%), Positives = 277/689 (40%), Gaps = 85/689 (12%)
Query: 128 KVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSE 187
KV+ L + +EE + + E K + + K++++ S + + + L++E
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906
Query: 188 HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQ 247
+ + EA E RL + + + I+ +E LE + Q+LQ +++ + +Q
Sbjct: 907 TELYAEA--------EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958
Query: 248 LFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAEL--NATIRKLEDRNTLL 305
+ D E + R + ++ ++ A I+KLED ++
Sbjct: 959 ML---------------------DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 997
Query: 306 GDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKI 365
D+ N+L K K L +R +L +L EEK K +TK ++ I
Sbjct: 998 DDQNNKLSK--------------ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1043
Query: 366 TS-HPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSK 424
+ LKK + QE E LK ++ + E D + I K + +
Sbjct: 1044 SELEVRLKK--------EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK- 1094
Query: 425 PIKRPVLDPFIGYDEDSMDSETSSMASFR-TDRTPATPDDDLD-ESLAAEESELRFRQLT 482
K L + +D + + +++ R + + +DLD E A ++E + R L
Sbjct: 1095 --KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1152
Query: 483 KEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHW 542
+E +AL+ E T ++E +A+ + + VL+ KA E+ + AQ
Sbjct: 1153 EELEALKTEL----EDTLDSTATQQELRAKREQEVTVLK-KALDEETRSHEAQV------ 1201
Query: 543 VEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELL--EFRNLELEERERRSPP 600
E +Q + +EL E++E+ + L + Q +N L E R L ++E
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261
Query: 601 FNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQL--DILGDNGNLRNEEQVAIIQAST 658
L+ V LQ C + D + +L ++ G L E AI A
Sbjct: 1262 KKLEAQ-----VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316
Query: 659 VLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQE 718
V SL+ + E + QK + + + + Q + + L+++LD +A I
Sbjct: 1317 VASLSSQLQDTQELLQEETRQK-LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1375
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQ 778
L L ++ ++ E+ ++ + +E L +Q K+ YD L++ LQ
Sbjct: 1376 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD--KLEKTKNRLQ 1433
Query: 779 QAHQRIRDLEDKTDIQKRQIKDLEEKSNR 807
Q + DL D Q++ + +LE+K +
Sbjct: 1434 ---QELDDLVVDLDNQRQLVSNLEKKQRK 1459
Score = 82.4 bits (202), Expect = 2e-15
Identities = 176/809 (21%), Positives = 323/809 (39%), Gaps = 143/809 (17%)
Query: 72 ELKAKLHE-EKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVR 130
E++AK E +K KE Q EN +K+ EQ+ S+ + ++ ++L++ + +VR
Sbjct: 860 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 131 TA--------------LTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQA 176
A +E E+ + ER K+ Q++ DL+ ++ +EA +Q
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQL 978
Query: 177 DKI----KAGDLRSEHQSHQEAISKIKWESERDIRRLMDE-IKAKDRIIFSLEKELETQT 231
+K+ K L E + +K+ E R+L++E I + E++ + T
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKE-----RKLLEERISDLTTNLAEEEEKAKNLT 1033
Query: 232 GYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAEL 291
K + L+ +L +++ + KR++ G A D E + DL Q +IAEL
Sbjct: 1034 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA--DL---QAQIAEL 1088
Query: 292 NATIRKLEDR----NTLLGDE---RNELLKRVRETEKQCKPLLE--------RNKCLAKR 336
+ K E+ L DE +N LK++RE E L E RNK ++
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 337 NDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQV 396
D + E+L+A+ E + + + L+ A EQE LK
Sbjct: 1149 RD--------LGEELEALKTELEDTLDSTATQQELR----------AKREQEVTVLK--- 1187
Query: 397 IEQQNIIDELTRDREKLIR--RRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRT 454
+DE TR E ++ R+KH ++ +E + E A
Sbjct: 1188 ----KALDEETRSHEAQVQEMRQKHAQA--------------VEELTEQLEQFKRAKANL 1229
Query: 455 DRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQ-- 512
D+ T + + + LA E L + E++ ++ A +QE D ER A+A+
Sbjct: 1230 DKNKQTLEKE-NADLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGER-ARAELN 1286
Query: 513 ---EQLQAEVLRYKAKIEDLEATLAQKGQD----SHWVEDKQLFI----KRNQELLEKIE 561
+LQ EV + + E + +D S ++D Q + ++ + K+
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 562 KQEAENHRLQQELQDARDQNELLEFR----NLELEERERRSPPFNLQIHPFSDGVSALQ- 616
+ E E + LQ +L + + + LE N++L + +++ F + +G Q
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406
Query: 617 --------------IYCMKEGVKD---VNIPDLIKQLDILGD-NGNLRNEEQVAIIQAST 658
Y E K+ + DL+ LD NL +++ +
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466
Query: 659 VLSLAEKWIQQIEGAEAALHQ---KMMELESDMEQFCKIKGYLEE-------ELDYRKQA 708
+++ K+ + + AEA + K + L +E+ + K LE E++ +
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526
Query: 709 LDQAYMRIQELEAT--LYNALQQETVIKFGELLSEKQQEE-----LRTAVEKLRRQMLRK 761
D + ELE + +E + EL E Q E L ++ L+ Q R
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586
Query: 762 SREYDCQILQERMELLQQAHQRIRDLEDK 790
+ D Q ++R +L +Q H+ +LED+
Sbjct: 1587 LQARDEQNEEKRRQLQRQLHEYETELEDE 1615
Score = 77.8 bits (190), Expect = 4e-14
Identities = 142/698 (20%), Positives = 280/698 (40%), Gaps = 110/698 (15%)
Query: 147 TERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDI 206
TE LLQE +T E + + A K + ++ E ++ E E E
Sbjct: 893 TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE-------EEEDRG 945
Query: 207 RRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQK-------EALDEQLFLVKEAECNMS 259
++L E K + + LE++LE + QKLQL+K + L++++ ++ + +S
Sbjct: 946 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 1005
Query: 260 SPKREIPGRAGDGSEHCSSPDLR---------RNQKRIAELNATIRKLEDRNTLLGDERN 310
++ + R D + + + + + +++ I+EL ++K E R
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE-------KSRQ 1058
Query: 311 ELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLK-AVTKENSEMREKITSHP 369
EL K R+ E E+ L + EL + L + EE+L+ A+ + + E+ +K +
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK---NN 1115
Query: 370 PLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRP 429
LKK++ L + + Q +D R K ++++ +
Sbjct: 1116 ALKKIRELEG---------------HISDLQEDLDSERAARNKAEKQKRDLGEELEALKT 1160
Query: 430 VLDPFIGYDEDSMDSETSSMASFRTDRTPATP--DDDLDESLAAEESELRFRQLTKEYQA 487
L ED++DS T++ R R LDE + E+++ Q
Sbjct: 1161 EL-------EDTLDS-TATQQELRAKREQEVTVLKKALDEETRSHEAQV---------QE 1203
Query: 488 LQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQ 547
+++ +A E+ ++ + AKA + L + + DL L GQ VE K+
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL--EKENADLAGELRVLGQAKQEVEHKK 1261
Query: 548 LFIKRNQELLEKIEKQEAENHRLQQELQDA--RDQNELLEFRNLELEERERRSPPFNLQI 605
K+ + +++++ + ++ R + EL D + QNE+ + L E E ++ +
Sbjct: 1262 ---KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-LNEAEGKAIKLAKDV 1317
Query: 606 HPFSDGVSALQIYCMKEGVKDVNIPDLIKQL--------DILGDNGNLRNEEQVAIIQAS 657
S + Q +E + +N+ ++QL D L + + + I +
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 658 TVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFC--------------KIKGYLEEELD 703
LS ++K +Q AL + + ++E K K L++ELD
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437
Query: 704 YRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSR 763
LD + LE + KF +LL+E++ + A E+ R + + +
Sbjct: 1438 DLVVDLDNQRQLVSNLE---------KKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 764 EYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDL 801
E L +E +A + +LE + K +++DL
Sbjct: 1489 ETKALSLARALE---EALEAKEELERTNKMLKAEMEDL 1523
Score = 75.9 bits (185), Expect = 1e-13
Identities = 137/699 (19%), Positives = 268/699 (38%), Gaps = 122/699 (17%)
Query: 7 NKGEKPEALIVALQA-------ANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIR 59
+K +K EA + LQ+ A +L K+ +Q E+ +++ E + + AK +
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318
Query: 60 ELE---QRKHTVLVTELKAKLH-EEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLK 115
L Q +L E + KL+ K+++L+ R +L Q ++EM + + +
Sbjct: 1319 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE----RHIS 1374
Query: 116 SALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIAD-------LKTAKKQVDE 168
+ L D A T+EA EE +K F E L Q+ + L+ K ++ +
Sbjct: 1375 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1434
Query: 169 ALSNMIQADKIKAGDLRSEHQSHQEAISKI---------KWESERD-------------- 205
L +++ D L S + Q ++ K+ ERD
Sbjct: 1435 ELDDLV-VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493
Query: 206 --IRRLMDEIKAKDRI------------------------IFSLEKELETQTGYVQKLQL 239
R L + ++AK+ + + LEK +++++
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 240 QKEALDEQLFLVKEA----ECNMSSPK----REIPGRAGDGSE---------HCSSPDLR 282
Q E L+++L ++A E NM + K R++ R E H +L
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Query: 283 RNQKRIAELNATIRKLEDRNT---LLGDE----RNELLKRVRETEKQCKPLLERNKCLAK 335
+K+ A A +KLE L D R E +K++R+ + Q K +
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1673
Query: 336 RNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQ 395
DE+ + + E+K K++ + +++E + + +K L + A E +
Sbjct: 1674 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS------ 1727
Query: 396 VIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTD 455
+ +N + + R E I + + + + + + ++ +A T+
Sbjct: 1728 -LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA---TE 1783
Query: 456 RTPATPDDDLDESLAAEESELRFR----------QLTKEYQALQRAYALLQEQTGGIIDA 505
R+ A ++ + L + ELR + + AL+ A L+EQ +A
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ--EA 1841
Query: 506 EREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQE- 564
+ A + L+ + + K + +E Q E +K+ + LE+ E++
Sbjct: 1842 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1901
Query: 565 ---AENHRLQQELQDARDQNELLEFRNLELEERERRSPP 600
A +LQ+EL +A + NE + L+ + R PP
Sbjct: 1902 RINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1940
Score = 38.1 bits (87), Expect = 0.033
Identities = 73/343 (21%), Positives = 144/343 (41%), Gaps = 59/343 (17%)
Query: 472 EESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEA 531
EE +L+ + +QA+ R Y + + AK Q+QL A K+
Sbjct: 787 EERDLKITDVIMAFQAMCRGY----------LARKAFAKRQQQLTA------MKVIQRNC 830
Query: 532 TLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLEL 591
K ++ W +LF K L ++ +QE E + ELQ +++ + E EL
Sbjct: 831 AAYLKLRNWQWW---RLFTKVKPLL--QVTRQEEEMQAKEDELQKTKERQQKAE---NEL 882
Query: 592 EERERRSPPFNLQIHPFSDGVSA-LQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQ 650
+E E++ + + + + A ++Y E ++ V + ++L+ + R EE+
Sbjct: 883 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR-VRLAAKKQELEEILHEMEARLEEE 941
Query: 651 VAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALD 710
E QQ++ + Q+M++LE +E EEE +K L+
Sbjct: 942 -------------EDRGQQLQAERKKMAQQMLDLEEQLE---------EEEAARQKLQLE 979
Query: 711 Q--AYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAV---EKLRRQMLRKSREY 765
+ A +I++LE + Q + L E++ +L T + E+ + + + ++
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 766 DCQI--LQERMELLQQAHQRI----RDLEDKTDIQKRQIKDLE 802
+ I L+ R++ +++ Q + R LE QI DL+
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQ 1082
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 98.6 bits (244), Expect = 2e-20
Identities = 172/868 (19%), Positives = 357/868 (41%), Gaps = 125/868 (14%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLERE------------ 50
KK ++ E L L+ D ++ D+Q ++ + K +++K E E
Sbjct: 1044 KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI 1103
Query: 51 --KTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRD 108
K K+IRELE +++L+ L E+ +A ++ E E +T
Sbjct: 1104 AQKNNALKKIRELEGH-----ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDT 1158
Query: 109 GEIQRLKSALCALRDGSSDKVRTALTIEAR------EEARKLFDTERLKLLQEIADLKTA 162
+ + L A R+ ++ AL E R +E R+ +L +++ K A
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRA 1218
Query: 163 KKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFS 222
K +D+ + + + AG+LR Q+ QE K K + E ++ L + +R
Sbjct: 1219 KANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK-KLEAQVQELQSKCSDGERARAE 1277
Query: 223 LEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLR 282
L + V KLQ + E++ L + ++ + + D E L+
Sbjct: 1278 LNDK-------VHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQEL-----LQ 1325
Query: 283 RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
++ ++ +R+LE+ L D+ +E ++ + E+ L + K+ +
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 343 SLQRMEEKLKAVTKE----NSEMREKITSHPPLKKLKS-----LNDL--DQANEEQETEF 391
+++ +EE K KE + EK ++ L+K K+ L+DL D N+ Q
Sbjct: 1386 TVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSN 1445
Query: 392 LKLQ-------VIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDS 444
L+ + + E++NI + +R++ + + + L+ + E+
Sbjct: 1446 LEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEEL--E 1503
Query: 445 ETSSMASFRTDRTPATPDD------DLDESLAA-----EESELRFRQLTKEYQALQRAYA 493
T+ M + ++ DD +L++S A EE + + +L E QA + A
Sbjct: 1504 RTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKL 1563
Query: 494 LLQ---EQTGGIIDAEREAKAQE------QLQAEVLRYKAKIEDLE-----ATLAQKGQD 539
L+ + G + + +A+ ++ QLQ ++ Y+ ++ED A A+K +
Sbjct: 1564 RLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLE 1623
Query: 540 SHWVEDKQL----FIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERE 595
++D +L IK +E ++++ K +A+ Q+EL+DAR + + +E E
Sbjct: 1624 GD-LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIF---ATAKENE 1679
Query: 596 RRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQ 655
+++ + + ++A + KQ D+ +E++A
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAE--------------RARKQADL--------EKEELAEEL 1717
Query: 656 ASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMR 715
AS++ ++ + L ++ +LE ++E+ +G +E D ++A QA
Sbjct: 1718 ASSLSGR-----NALQDEKRRLEARIAQLEEELEEE---QGNMEAMSDRVRKATQQAEQL 1769
Query: 716 IQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERME 775
EL A + E+ + E+Q +ELR+ + ++ + K + + + +
Sbjct: 1770 SNELATERSTAQKNESARQ----QLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 776 LLQQAHQRIRDLEDKTDIQKRQIKDLEE 803
L +Q Q R+ + T K++ K L+E
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Score = 92.8 bits (229), Expect = 1e-18
Identities = 174/925 (18%), Positives = 365/925 (39%), Gaps = 192/925 (20%)
Query: 19 LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELE---------------- 62
LQA + + ++ D++ +L +E++ KL+ EK +I++LE
Sbjct: 941 LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE 1000
Query: 63 ----------------------------QRKHTVLVTELKAKL--HEEKMKELQAVRENL 92
+ KH +++EL+ +L E+ +EL+ ++ L
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 93 ------------------------IKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDK 128
+ + E+E+ + D EI + +AL +R+
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 129 VRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKA------- 181
+++ AR + ++ L +E+ LKT ++++ L + +++A
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKT---ELEDTLDSTATQQELRAKREQEVT 1177
Query: 182 ---GDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQ 238
L E +SH+ + +++ + + + L ++++ R +L+K +T L+
Sbjct: 1178 VLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT-------LE 1230
Query: 239 LQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKL 298
+ L +L ++ +A+ + K+++ + + CS + R AELN + KL
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERAR-----AELNDKVHKL 1285
Query: 299 EDR----NTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDE---LMVSLQRMEEK- 350
++ +L + + +K ++ L + + L + + + L+++EE+
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 351 --LKAVTKENSEMREKITSH---------PPLKKLKSLNDLDQANEEQETEFLKLQVIEQ 399
L+ E E ++ + H KKL+ +A EE + F
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF-------- 1397
Query: 400 QNIIDELTRD-REKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTP 458
Q I+ LT+ EK K ++ +++ + D + D + D+
Sbjct: 1398 QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL 1457
Query: 459 ATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAE 518
A + ++ A E KE +AL A AL E +A+E+L+
Sbjct: 1458 A-EEKNISSKYADERDRAEAEAREKETKALSLARAL-----------EEALEAKEELERT 1505
Query: 519 VLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDAR 578
KA++EDL ++ G++ H +E K + L ++E+ + + L+ ELQ
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELE------KSKRALETQMEEMKTQLEELEDELQATE 1559
Query: 579 DQNELLEF----------RNLEL--EERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKD 626
D LE R+L+ E+ E + Q+H + + +
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1619
Query: 627 VNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAAL--------- 677
+ +K L++ D+ EE AI Q + + + + +++E A A+
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREE--AIKQLRKLQAQMKDFQRELEDARASRDEIFATAKE 1677
Query: 678 -HQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFG 736
+K LE+D+ Q L+E+L ++A QA + +EL L ++L ++
Sbjct: 1678 NEKKAKSLEADLMQ-------LQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ-- 1728
Query: 737 ELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERM-ELLQQAHQRIRDL-EDKTDIQ 794
EK++ E R A +L ++ + + + + + +R+ + QQA Q +L +++ Q
Sbjct: 1729 ---DEKRRLEARIA--QLEEEL--EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 795 K---------RQIKDLEEKSNRKHG 810
K RQ K+L K + G
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEG 1806
Score = 84.0 bits (206), Expect = 5e-16
Identities = 146/689 (21%), Positives = 277/689 (40%), Gaps = 85/689 (12%)
Query: 128 KVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSE 187
KV+ L + +EE + + E K + + K++++ S + + + L++E
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899
Query: 188 HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQ 247
+ + EA E RL + + + I+ +E LE + Q+LQ +++ + +Q
Sbjct: 900 TELYAEA--------EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951
Query: 248 LFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAEL--NATIRKLEDRNTLL 305
+ D E + R + ++ ++ A I+KLED ++
Sbjct: 952 ML---------------------DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVM 990
Query: 306 GDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKI 365
D+ N+L K K L +R +L +L EEK K +TK ++ I
Sbjct: 991 DDQNNKLSK--------------ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI 1036
Query: 366 TS-HPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSK 424
+ LKK + QE E LK ++ + E D + I K + +
Sbjct: 1037 SELEVRLKK--------EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAK- 1087
Query: 425 PIKRPVLDPFIGYDEDSMDSETSSMASFR-TDRTPATPDDDLD-ESLAAEESELRFRQLT 482
K L + +D + + +++ R + + +DLD E A ++E + R L
Sbjct: 1088 --KEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLG 1145
Query: 483 KEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHW 542
+E +AL+ E T ++E +A+ + + VL+ KA E+ + AQ
Sbjct: 1146 EELEALKTEL----EDTLDSTATQQELRAKREQEVTVLK-KALDEETRSHEAQV------ 1194
Query: 543 VEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELL--EFRNLELEERERRSPP 600
E +Q + +EL E++E+ + L + Q +N L E R L ++E
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254
Query: 601 FNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQL--DILGDNGNLRNEEQVAIIQAST 658
L+ V LQ C + D + +L ++ G L E AI A
Sbjct: 1255 KKLEAQ-----VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309
Query: 659 VLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQE 718
V SL+ + E + QK + + + + Q + + L+++LD +A I
Sbjct: 1310 VASLSSQLQDTQELLQEETRQK-LNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHIST 1368
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQ 778
L L ++ ++ E+ ++ + +E L +Q K+ YD L++ LQ
Sbjct: 1369 LNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD--KLEKTKNRLQ 1426
Query: 779 QAHQRIRDLEDKTDIQKRQIKDLEEKSNR 807
Q + DL D Q++ + +LE+K +
Sbjct: 1427 ---QELDDLVVDLDNQRQLVSNLEKKQRK 1452
Score = 82.4 bits (202), Expect = 2e-15
Identities = 176/809 (21%), Positives = 323/809 (39%), Gaps = 143/809 (17%)
Query: 72 ELKAKLHE-EKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVR 130
E++AK E +K KE Q EN +K+ EQ+ S+ + ++ ++L++ + +VR
Sbjct: 853 EMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 131 TA--------------LTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQA 176
A +E E+ + ER K+ Q++ DL+ ++ +EA +Q
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE-EEAARQKLQL 971
Query: 177 DKI----KAGDLRSEHQSHQEAISKIKWESERDIRRLMDE-IKAKDRIIFSLEKELETQT 231
+K+ K L E + +K+ E R+L++E I + E++ + T
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKE-----RKLLEERISDLTTNLAEEEEKAKNLT 1026
Query: 232 GYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAEL 291
K + L+ +L +++ + KR++ G A D E + DL Q +IAEL
Sbjct: 1027 KLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA--DL---QAQIAEL 1081
Query: 292 NATIRKLEDR----NTLLGDE---RNELLKRVRETEKQCKPLLE--------RNKCLAKR 336
+ K E+ L DE +N LK++RE E L E RNK ++
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 337 NDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQV 396
D + E+L+A+ E + + + L+ A EQE LK
Sbjct: 1142 RD--------LGEELEALKTELEDTLDSTATQQELR----------AKREQEVTVLK--- 1180
Query: 397 IEQQNIIDELTRDREKLIR--RRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRT 454
+DE TR E ++ R+KH ++ +E + E A
Sbjct: 1181 ----KALDEETRSHEAQVQEMRQKHAQA--------------VEELTEQLEQFKRAKANL 1222
Query: 455 DRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQ-- 512
D+ T + + + LA E L + E++ ++ A +QE D ER A+A+
Sbjct: 1223 DKNKQTLEKE-NADLAGELRVLGQAKQEVEHKK-KKLEAQVQELQSKCSDGER-ARAELN 1279
Query: 513 ---EQLQAEVLRYKAKIEDLEATLAQKGQD----SHWVEDKQLFI----KRNQELLEKIE 561
+LQ EV + + E + +D S ++D Q + ++ + K+
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 562 KQEAENHRLQQELQDARDQNELLEFR----NLELEERERRSPPFNLQIHPFSDGVSALQ- 616
+ E E + LQ +L + + + LE N++L + +++ F + +G Q
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399
Query: 617 --------------IYCMKEGVKD---VNIPDLIKQLDILGD-NGNLRNEEQVAIIQAST 658
Y E K+ + DL+ LD NL +++ +
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459
Query: 659 VLSLAEKWIQQIEGAEAALHQ---KMMELESDMEQFCKIKGYLEE-------ELDYRKQA 708
+++ K+ + + AEA + K + L +E+ + K LE E++ +
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519
Query: 709 LDQAYMRIQELEAT--LYNALQQETVIKFGELLSEKQQEE-----LRTAVEKLRRQMLRK 761
D + ELE + +E + EL E Q E L ++ L+ Q R
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1579
Query: 762 SREYDCQILQERMELLQQAHQRIRDLEDK 790
+ D Q ++R +L +Q H+ +LED+
Sbjct: 1580 LQARDEQNEEKRRQLQRQLHEYETELEDE 1608
Score = 77.8 bits (190), Expect = 4e-14
Identities = 142/698 (20%), Positives = 280/698 (40%), Gaps = 110/698 (15%)
Query: 147 TERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDI 206
TE LLQE +T E + + A K + ++ E ++ E E E
Sbjct: 886 TEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE-------EEEDRG 938
Query: 207 RRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQK-------EALDEQLFLVKEAECNMS 259
++L E K + + LE++LE + QKLQL+K + L++++ ++ + +S
Sbjct: 939 QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLS 998
Query: 260 SPKREIPGRAGDGSEHCSSPDLR---------RNQKRIAELNATIRKLEDRNTLLGDERN 310
++ + R D + + + + + +++ I+EL ++K E R
Sbjct: 999 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEE-------KSRQ 1051
Query: 311 ELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLK-AVTKENSEMREKITSHP 369
EL K R+ E E+ L + EL + L + EE+L+ A+ + + E+ +K +
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQK---NN 1108
Query: 370 PLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRP 429
LKK++ L + + Q +D R K ++++ +
Sbjct: 1109 ALKKIRELEG---------------HISDLQEDLDSERAARNKAEKQKRDLGEELEALKT 1153
Query: 430 VLDPFIGYDEDSMDSETSSMASFRTDRTPATP--DDDLDESLAAEESELRFRQLTKEYQA 487
L ED++DS T++ R R LDE + E+++ Q
Sbjct: 1154 EL-------EDTLDS-TATQQELRAKREQEVTVLKKALDEETRSHEAQV---------QE 1196
Query: 488 LQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQ 547
+++ +A E+ ++ + AKA + L + + DL L GQ VE K+
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL--EKENADLAGELRVLGQAKQEVEHKK 1254
Query: 548 LFIKRNQELLEKIEKQEAENHRLQQELQDA--RDQNELLEFRNLELEERERRSPPFNLQI 605
K+ + +++++ + ++ R + EL D + QNE+ + L E E ++ +
Sbjct: 1255 ---KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGM-LNEAEGKAIKLAKDV 1310
Query: 606 HPFSDGVSALQIYCMKEGVKDVNIPDLIKQL--------DILGDNGNLRNEEQVAIIQAS 657
S + Q +E + +N+ ++QL D L + + + I +
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 658 TVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFC--------------KIKGYLEEELD 703
LS ++K +Q AL + + ++E K K L++ELD
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430
Query: 704 YRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSR 763
LD + LE + KF +LL+E++ + A E+ R + + +
Sbjct: 1431 DLVVDLDNQRQLVSNLE---------KKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 764 EYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDL 801
E L +E +A + +LE + K +++DL
Sbjct: 1482 ETKALSLARALE---EALEAKEELERTNKMLKAEMEDL 1516
Score = 75.9 bits (185), Expect = 1e-13
Identities = 137/699 (19%), Positives = 268/699 (38%), Gaps = 122/699 (17%)
Query: 7 NKGEKPEALIVALQA-------ANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIR 59
+K +K EA + LQ+ A +L K+ +Q E+ +++ E + + AK +
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311
Query: 60 ELE---QRKHTVLVTELKAKLH-EEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLK 115
L Q +L E + KL+ K+++L+ R +L Q ++EM + + +
Sbjct: 1312 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE----RHIS 1367
Query: 116 SALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIAD-------LKTAKKQVDE 168
+ L D A T+EA EE +K F E L Q+ + L+ K ++ +
Sbjct: 1368 TLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQ 1427
Query: 169 ALSNMIQADKIKAGDLRSEHQSHQEAISKI---------KWESERD-------------- 205
L +++ D L S + Q ++ K+ ERD
Sbjct: 1428 ELDDLV-VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486
Query: 206 --IRRLMDEIKAKDRI------------------------IFSLEKELETQTGYVQKLQL 239
R L + ++AK+ + + LEK +++++
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 240 QKEALDEQLFLVKEA----ECNMSSPK----REIPGRAGDGSE---------HCSSPDLR 282
Q E L+++L ++A E NM + K R++ R E H +L
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Query: 283 RNQKRIAELNATIRKLEDRNT---LLGDE----RNELLKRVRETEKQCKPLLERNKCLAK 335
+K+ A A +KLE L D R E +K++R+ + Q K +
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARA 1666
Query: 336 RNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQ 395
DE+ + + E+K K++ + +++E + + +K L + A E +
Sbjct: 1667 SRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASS------ 1720
Query: 396 VIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTD 455
+ +N + + R E I + + + + + + ++ +A T+
Sbjct: 1721 -LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA---TE 1776
Query: 456 RTPATPDDDLDESLAAEESELRFR----------QLTKEYQALQRAYALLQEQTGGIIDA 505
R+ A ++ + L + ELR + + AL+ A L+EQ +A
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQ--EA 1834
Query: 506 EREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQE- 564
+ A + L+ + + K + +E Q E +K+ + LE+ E++
Sbjct: 1835 REKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQ 1894
Query: 565 ---AENHRLQQELQDARDQNELLEFRNLELEERERRSPP 600
A +LQ+EL +A + NE + L+ + R PP
Sbjct: 1895 RINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1933
Score = 38.1 bits (87), Expect = 0.033
Identities = 73/343 (21%), Positives = 144/343 (41%), Gaps = 59/343 (17%)
Query: 472 EESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEA 531
EE +L+ + +QA+ R Y + + AK Q+QL A K+
Sbjct: 780 EERDLKITDVIMAFQAMCRGY----------LARKAFAKRQQQLTA------MKVIQRNC 823
Query: 532 TLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLEL 591
K ++ W +LF K L ++ +QE E + ELQ +++ + E EL
Sbjct: 824 AAYLKLRNWQWW---RLFTKVKPLL--QVTRQEEEMQAKEDELQKTKERQQKAE---NEL 875
Query: 592 EERERRSPPFNLQIHPFSDGVSA-LQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQ 650
+E E++ + + + + A ++Y E ++ V + ++L+ + R EE+
Sbjct: 876 KELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMR-VRLAAKKQELEEILHEMEARLEEE 934
Query: 651 VAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALD 710
E QQ++ + Q+M++LE +E EEE +K L+
Sbjct: 935 -------------EDRGQQLQAERKKMAQQMLDLEEQLE---------EEEAARQKLQLE 972
Query: 711 Q--AYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAV---EKLRRQMLRKSREY 765
+ A +I++LE + Q + L E++ +L T + E+ + + + ++
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 766 DCQI--LQERMELLQQAHQRI----RDLEDKTDIQKRQIKDLE 802
+ I L+ R++ +++ Q + R LE QI DL+
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQ 1075
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 98.6 bits (244), Expect = 2e-20
Identities = 173/862 (20%), Positives = 364/862 (42%), Gaps = 123/862 (14%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR- 64
++K E +AL + LQ ++L+ ++ +++ E+ E++ +K E++++ ++ + E+ +R
Sbjct: 1095 QSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154
Query: 65 KHTVLVTELKAKLHEEKMKELQAVRENLIK---QHEQEMSRTVKVRDGEIQRLKSALCAL 121
+ T + ++++++ E Q +R +L + QHE + K + L + L
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1214
Query: 122 RDGSS--DKVRTALTIEAREEARKLFDTERLK---------LLQEIADLKTAKKQVDEAL 170
+ +K ++ + +E + A + + K L +++++KT K++ + L
Sbjct: 1215 QRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKT-KEEEQQRL 1273
Query: 171 SNMIQADKIK----AGDLRSEHQSHQEAISKIK-------WESERDIRRLMDEIKAKDRI 219
N + A + + +G+ + +S++ + E R+L +EIKAK +
Sbjct: 1274 INDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSAL 1333
Query: 220 IFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSP 279
+L+ ++ + ++EA E + +A ++ + + A +E
Sbjct: 1334 AHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEA 1393
Query: 280 D------LRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCL 333
L+ ++ + +NA LE L +E +L+ V T C L ++ +
Sbjct: 1394 KKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNF 1453
Query: 334 AKRNDELMVSLQRMEEKLKAVTKENSEMREKITS-----HPPLKKLKSLNDLDQANEEQE 388
K E + +L+A KE+ + ++ L +L++L + N +QE
Sbjct: 1454 DKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKR-ENKNLQQE 1512
Query: 389 TEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSM---DSE 445
L Q+ E I EL EK+ ++ + +S + + ++E + E
Sbjct: 1513 ISDLTEQIAEGGKRIHEL----EKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLE 1568
Query: 446 TSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQR--AYALLQEQTGGII 503
+ + S DR A D+++D+ + Q T + + R A L ++ G +
Sbjct: 1569 LNQVKS-EVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1627
Query: 504 DAEREAKAQEQLQAEVLRY----KAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEK 559
+ E + ++ AE LR +A ++D + L + ++++ ++R LL+
Sbjct: 1628 EMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQA 1687
Query: 560 --------IEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDG 611
+E+ E +QEL DA ++ +LL +N L +++
Sbjct: 1688 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK----------LETD 1737
Query: 612 VSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIE 671
+S +Q + D+I++ RN E+ A + +AE+ +++ +
Sbjct: 1738 ISQIQ----------GEMEDIIQE---------ARNAEEKAKKAITDAAMMAEE-LKKEQ 1777
Query: 672 GAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQ-ALDQAYMRIQELEATLYNALQQE 730
A L + LE ++ L+ LD +Q AL +IQ+LEA
Sbjct: 1778 DTSAHLERMKKNLEQTVKD-------LQHRLDEAEQLALKGGKKQIQKLEA--------- 1821
Query: 731 TVIKFGELLSEKQQEELRT--AVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLE 788
+ EL E + E+ R AV+ LR+ RK +E Q ++R +L R++DL
Sbjct: 1822 ---RVRELEGEVESEQKRNVEAVKGLRKHE-RKVKELTYQTEEDRKNIL-----RLQDLV 1872
Query: 789 DKTDIQ----KRQIKDLEEKSN 806
DK + KRQ ++ EE+SN
Sbjct: 1873 DKLQAKVKSYKRQAEEAEEQSN 1894
Score = 92.4 bits (228), Expect = 1e-18
Identities = 178/844 (21%), Positives = 349/844 (41%), Gaps = 166/844 (19%)
Query: 1 MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRE 60
++K + E E ++ +Q N DL+ ++ L + + +L + K Q +I+E
Sbjct: 867 LAKTEAKRKELEEKMVTLMQEKN-DLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKE 925
Query: 61 LEQRKH-----TVLVTELKAKLHEE----------------KMKELQAVRENLIKQHEQE 99
+ +R +T K KL +E K+++ + EN +K +E
Sbjct: 926 VTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEE 985
Query: 100 MSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADL 159
M+ D I +L AL++ +T ++A E+ ++KL Q++ DL
Sbjct: 986 MAGL----DETIAKLTKEKKALQEAHQ---QTLDDLQAEEDKVNTLTKAKIKLEQQVDDL 1038
Query: 160 KTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRI 219
+ + +Q + ++ +A + GDL+ +S + E D ++L +++K K+
Sbjct: 1039 EGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDI--------ENDKQQLDEKLKKKEFE 1090
Query: 220 IFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPG-RAGDGSEHCSS 278
+ L+ ++E + +QLQK+ +KE + + + EI RA
Sbjct: 1091 MSGLQSKIEDEQAL--GMQLQKK--------IKELQARIEELEEEIEAERASRAKAEKQR 1140
Query: 279 PDLRRNQKRIAE--------LNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERN 330
DL R + I+E +A I + R R +L + + E L +++
Sbjct: 1141 SDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1200
Query: 331 KCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKI----TSHPPLKKLK-SLNDLDQANE 385
E + +LQR+++KL+ KE SEM+ +I ++ + K K +L + +A E
Sbjct: 1201 ADSVAELGEQIDNLQRVKQKLE---KEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALE 1257
Query: 386 EQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSE 445
+Q +E +K + EQQ +I++LT R +L + S R + D D+
Sbjct: 1258 DQLSE-IKTKEEEQQRLINDLTAQRARL------QTESGEYSRQL---------DEKDTL 1301
Query: 446 TSSMASFRTDRTPATPDDDLDESLAAEESELRFRQ-LTKEYQALQRAYALLQEQTGGIID 504
S ++ + T ++E E E++ + L Q+ + LL+EQ +
Sbjct: 1302 VSQLSRGKQAFT-----QQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQ----YE 1352
Query: 505 AEREAKAQEQ-----LQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEK 559
E+EAKA+ Q +EV +++ K E + +++
Sbjct: 1353 EEQEAKAELQRAMSKANSEVAQWRTKYE--------------------------TDAIQR 1386
Query: 560 IEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYC 619
E+ E +L Q LQDA + E + + LE+ ++R
Sbjct: 1387 TEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQR---------------------- 1424
Query: 620 MKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQ 679
++ V+D+ I + RN +++ LAE W Q+ E A L
Sbjct: 1425 LQNEVEDLMIDVERTNAACAALDKKQRNFDKI----------LAE-WKQKCEETHAELEA 1473
Query: 680 KMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQ--ETVIKFGE 737
E S + KIK EE LD + + L + +Q+ + L + + + + + +
Sbjct: 1474 SQKESRSLSTELFKIKNAYEESLD-QLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1532
Query: 738 LLSEKQQE--ELRTAVEKLRRQMLRKSREYDCQILQERMELLQ---QAHQRIRDLEDKTD 792
+ + +QE EL+ A+E+ + + +IL+ ++EL Q + ++I + +++ D
Sbjct: 1533 IKKQVEQEKSELQAALEEAEASL----EHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1588
Query: 793 IQKR 796
KR
Sbjct: 1589 QMKR 1592
Score = 69.7 bits (169), Expect = 1e-11
Identities = 132/655 (20%), Positives = 265/655 (40%), Gaps = 98/655 (14%)
Query: 179 IKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQ 238
+K+ + E + +E K K E + E K K+ LE+++ T LQ
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKT------EAKRKE-----LEEKMVTLMQEKNDLQ 892
Query: 239 LQKEALDEQLFLVKE-------AECNMSSPKREIPGRAGDGSEHCSSPDLRRNQ------ 285
LQ +A + L +E + + + +E+ RA D E + ++ +
Sbjct: 893 LQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS 952
Query: 286 ---KRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
K I +L T+ K+E ++ L + + ++ L + K L + + + +
Sbjct: 953 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1012
Query: 343 SLQRMEEKLKAVTKENSEMREKITS-HPPLKKLKSLN-DLDQANEEQETEFLKLQVIEQQ 400
LQ E+K+ +TK ++ +++ L++ K + DL++A + E + LKL Q+
Sbjct: 1013 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGD-LKL---AQE 1068
Query: 401 NIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPAT 460
+ +D + D+++L + K + G D + M + +
Sbjct: 1069 STMD-IENDKQQLDEKLKKKEFE----------MSGLQSKIEDEQALGMQLQKKIKELQA 1117
Query: 461 PDDDLDESLAAE-----ESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQL 515
++L+E + AE ++E + L++E + + E+ GG A+ E + +
Sbjct: 1118 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL----EEAGGATSAQIEMNKKREA 1173
Query: 516 QAEVLRYKAKIEDLE-----ATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRL 570
+ + +R + L+ ATL +K DS V + I Q + +K+EK+++E +
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKHADS--VAELGEQIDNLQRVKQKLEKEKSE---M 1228
Query: 571 QQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIP 630
+ E+ D E + LE+ R D +S ++ KE + I
Sbjct: 1229 KMEIDDLASNMETVSKAKGNLEKMCR----------ALEDQLSEIK---TKEEEQQRLIN 1275
Query: 631 DLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQ 690
DL Q R Q + S L + + Q+ + A Q++ EL+ +E+
Sbjct: 1276 DLTAQ----------RARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEE 1325
Query: 691 FCKIKGYLEEELDYRKQALD---QAYMRIQELEATLYNALQQETVIKFGELLSEKQQEEL 747
K K L L + D + Y QE +A L A+ + SE Q
Sbjct: 1326 EIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKAN--------SEVAQWRT 1377
Query: 748 RTAVEKLRR-QMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDL 801
+ + ++R + L ++++ Q LQ+ E ++ + + LE + +++DL
Sbjct: 1378 KYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDL 1432
Score = 61.2 bits (147), Expect = 4e-09
Identities = 92/433 (21%), Positives = 183/433 (42%), Gaps = 49/433 (11%)
Query: 4 KGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQ 63
K +N E+ + L+ N++L+ +++D+ ++ + ++ +LE+ K Q + EL+
Sbjct: 1487 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQ- 1545
Query: 64 RKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRD 123
+ E +A L E+ K L+ E + Q + E+ R + +D EI ++K +R
Sbjct: 1546 ----AALEEAEASLEHEEGKILRIQLE--LNQVKSEVDRKIAEKDEEIDQMKRN--HIRI 1597
Query: 124 GSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSN------MIQAD 177
S + I +R +A +L L + L A + EAL N +++
Sbjct: 1598 VESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDT 1657
Query: 178 KIKAGDLRSEHQSHQEAISKIKWES---ERDIRRLMDEIKAKDRIIFSLEKELETQTGYV 234
++ D + +E ++ ++ + + +I L ++ +R E+EL + V
Sbjct: 1658 QLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERV 1717
Query: 235 QKLQLQKEAL---------------DEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSP 279
Q L Q +L E +++EA K+ I A E
Sbjct: 1718 QLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQ 1777
Query: 280 DLRRNQKRIAE-LNATIRKLEDRNTLLGDERNELL-----KRVRETEKQCKPLLERNKCL 333
D + +R+ + L T++ L+ R DE +L K++++ E + + L +
Sbjct: 1778 DTSAHLERMKKNLEQTVKDLQHRL----DEAEQLALKGGKKQIQKLEARVRELEGEVESE 1833
Query: 334 AKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPL-----KKLKSL-NDLDQANEEQ 387
KRN E + L++ E K+K +T + E R+ I L K+KS ++A E+
Sbjct: 1834 QKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQS 1893
Query: 388 ETEFLKLQVIEQQ 400
K + I+ +
Sbjct: 1894 NVNLSKFRRIQHE 1906
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 97.8 bits (242), Expect = 4e-20
Identities = 147/628 (23%), Positives = 273/628 (43%), Gaps = 79/628 (12%)
Query: 1 MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKS--KVSKLEREKTQEAKRI 58
M K+ K E +AL Q + E ++ + D +E+ +E+ +++LE K + K++
Sbjct: 819 MKKENMKKDEALKAL--QNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQL 876
Query: 59 RELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSAL 118
++ + + L ELK K H + Q V Q +Q+M + +R+GE++ ++ L
Sbjct: 877 KKKSEEVYC-LQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKL 935
Query: 119 CALRDGSSDKVRTALTIEAREEARKLFDTE-RLKLLQEIADLKTAKKQVDEALSNMIQAD 177
+ K+ L + A KL E + + ADLK +++V E L+ +
Sbjct: 936 ----EKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLK--RQKVIE-LTGTARQV 988
Query: 178 KIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKL 237
KI+ + E ++ I +K + E L D I+ + ELE +T V++L
Sbjct: 989 KIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQ----LDMILDQTKTELEKKTNAVKEL 1044
Query: 238 QLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRK 297
E+L E E + KRE+ + + +L+ +++ EL ++K
Sbjct: 1045 --------EKLQHSTETELTEALQKREVL----ETELQNAHGELKSTLRQLQELRDVLQK 1092
Query: 298 ----LEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKA 353
LE++ T + D EL + E E + + LLE ++ L +RN EL ++
Sbjct: 1093 AQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMT 1152
Query: 354 VTKENSEMREKITSHPPL------------KKLKSLNDLDQANEEQ--ETEFLKLQVIEQ 399
+ + EM +KI K+++SLND Q +EQ E EF+ LQ
Sbjct: 1153 IREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQ---N 1209
Query: 400 QNIIDELTRDREKLIRRRKHRRS---------SKPIKRPV-LDPFIGYDEDSMDSETSSM 449
+ I +L ++ E+ +R K S + K + L + + + + + +
Sbjct: 1210 EQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTEL 1269
Query: 450 ASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREA 509
A R + A + E L++E ++ +QL+KE A L E+ G REA
Sbjct: 1270 AEARHQQVQAQRE---IERLSSELEDM--KQLSKEKDAHGNH---LAEELGA--SKVREA 1319
Query: 510 KAQEQLQAEVLRYKAKIEDLEAT-----LAQKGQDSHWVEDKQLFIKRNQELLEKIEKQE 564
+ ++QAE+ + A++E L+ ++ + + W Q+L E++EK +
Sbjct: 1320 HLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEKAK 1379
Query: 565 AENHRLQQEL----QDARDQNELLEFRN 588
E Q + Q +D+NE++E N
Sbjct: 1380 LELEEAQDTVSNLHQQVQDRNEVIEAAN 1407
Score = 79.0 bits (193), Expect = 2e-14
Identities = 145/774 (18%), Positives = 310/774 (40%), Gaps = 150/774 (19%)
Query: 10 EKPEALIVALQAANEDLRTKLTD-------IQIELHQEKSKVSKLEREKTQEAKRIRELE 62
E+ ++ ++A N DL+ + IQ EL ++ S SKLE E T++ ++ LE
Sbjct: 644 EELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLE 703
Query: 63 QRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGE--IQRLKSALCA 120
++ EEK+ ++ + ++ M + K+R E I +C
Sbjct: 704 KQL-------------EEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICL 750
Query: 121 LRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIK 180
A E+A+K+ + ++ ++I L+ ++ D+ + +
Sbjct: 751 ----------------AFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSML 794
Query: 181 AGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ 240
D+ + Q H E++ ++ ES+ ++++ E KD + +L+ ++ +T V++L
Sbjct: 795 QQDIICK-QHHLESLDRLLTESKGEMKK---ENMKKDEALKALQNQVSEETIKVRQLDSA 850
Query: 241 KEALDEQLFL-VKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLE 299
E E+L L + + E N ++++ + S ++ QK + N ++++
Sbjct: 851 LEICKEELVLHLNQLEGNKEKFEKQLKKK---------SEEVYCLQKELKIKNHSLQETS 901
Query: 300 DRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENS 359
++N +L + + +++ + L + L K+ +L LQ+ E ++
Sbjct: 902 EQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKME 961
Query: 360 EMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKH 419
E E LK+ K + A + + IE +EL++ EK I K
Sbjct: 962 EKCESAAHEADLKRQKVIELTGTARQVK---------IEMDQYKEELSK-MEKEIMHLKR 1011
Query: 420 RRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFR 479
+K + LD + + ++ +T+++ ++ + + +L E+L ++ E+
Sbjct: 1012 DGENKAMHLSQLDMILDQTKTELEKKTNAVKEL--EKLQHSTETELTEAL--QKREVLET 1067
Query: 480 QLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQD 539
+L + L+ LQE R+ + QL E +Y I+DL A L + +
Sbjct: 1068 ELQNAHGELKSTLRQLQEL--------RDVLQKAQLSLEE-KYTT-IKDLTAELRECKME 1117
Query: 540 SHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSP 599
+EDK+ QELLE ++ L+ RN EL++R +
Sbjct: 1118 ---IEDKK------QELLE---------------------MDQALKERNWELKQRAAQVT 1147
Query: 600 PFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTV 659
++ I R E + II+
Sbjct: 1148 HLDMTIREH-------------------------------------RGEMEQKIIKLEGT 1170
Query: 660 LSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQEL 719
L +E +++ +L+ K+ + + + I E+E+ K+ +++ R++E+
Sbjct: 1171 LEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEM 1230
Query: 720 EATL-----YNALQQETVIKFGE--LLSEKQQEELRTAVEKLRRQMLRKSREYD 766
E+ + Y A Q + I G+ L+ +Q + T + + R Q ++ RE +
Sbjct: 1231 ESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIE 1284
Score = 67.8 bits (164), Expect = 4e-11
Identities = 167/837 (19%), Positives = 349/837 (41%), Gaps = 150/837 (17%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELE 62
K R K K L N L TK I EL Q ++KVS LE + Q+A + LE
Sbjct: 232 KSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQ-QQAASVPILE 290
Query: 63 QRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALR 122
++ + L+A++ + ++ ++++ E ++ ++ K+ + Q L+
Sbjct: 291 EQ-----IINLEAEV---------SAQDKVLREAENKLEQSQKMVIEKEQSLQ------- 329
Query: 123 DGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAG 182
E++EE KL ++ LL++ K A++Q
Sbjct: 330 -------------ESKEECIKL----KVDLLEQTKQGKRAERQ----------------- 355
Query: 183 DLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKE 242
R+E + E +SK + ++ + +++++A++ I LE+ L ++LQ +
Sbjct: 356 --RNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEI---LERNLTNCEKENKRLQERCG 410
Query: 243 ALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRN 302
+L ++KE R++ +G E ++ N + +A+L
Sbjct: 411 LYKSELEILKEK-------LRQLKEENNNGKEKLRIMAVK-NSEVMAQLT---------- 452
Query: 303 TLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMR 362
+ R +LK E E + + L ++ L N EL V + E+L +E R
Sbjct: 453 ----ESRQSILKLESELENKDEILRDKFS-LMNENRELKVRVAAQNERLDLCQQEIESSR 507
Query: 363 ------EKITSHPPLKK----LKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREK 412
EKI S PLK+ KS Q + E + E ++ ++ R K
Sbjct: 508 VELRSLEKIISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLV--ISELRIK 565
Query: 413 L-IRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAA 471
L I+ + ++ + L + DS +S S ++S T+ + ES+
Sbjct: 566 LAIKEAEIQKLHANLTANQLSQSLITCNDSQES--SKLSSLETEPVKLG-GHQVAESVKD 622
Query: 472 EESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEA 531
+ +Q KE Q L GI E+L+ ++++ +A+ DL+
Sbjct: 623 QNQHTMNKQYEKERQRL----------VTGI----------EELRTKLIQIEAENSDLKV 662
Query: 532 TLAQKGQDSHWVEDKQLFIKRNQELLE-KIEKQEAENHRLQQELQDARDQNELLEFRNLE 590
+A + ++++ L N LE ++ K+ ++ L+++L++ + +N E
Sbjct: 663 NMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAE 722
Query: 591 LEERERRSPPFNLQIHPFSDGVSAL--QIYCMKEGVKDVNIP---DLIKQLDILGDNGNL 645
LE+ N +I ++ +I E K +++ ++ KQ++ L L
Sbjct: 723 LEQELMEK---NEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERL--EAQL 777
Query: 646 RNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYR 705
++Q Q T+ L + I + E+ L + + E + +M++ K +E L
Sbjct: 778 EKKDQQFKEQEKTMSMLQQDIICKQHHLES-LDRLLTESKGEMKKENMKK---DEALKAL 833
Query: 706 KQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQ--QEELRTAVE---------KL 754
+ + + +++++L++ L ++E V+ +L K+ +++L+ E K+
Sbjct: 834 QNQVSEETIKVRQLDSAL-EICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKI 892
Query: 755 RRQMLRKSREYDCQI---LQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSNRK 808
+ L+++ E + + LQ++ ++LQQ R +LED ++Q+ LE++ ++
Sbjct: 893 KNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQ 949
Score = 32.0 bits (71), Expect = 2.4
Identities = 85/432 (19%), Positives = 174/432 (40%), Gaps = 78/432 (18%)
Query: 343 SLQRMEEKLKAVT-KENSEMR------EKIT-----SHPPLKKLKSLNDLDQANEEQETE 390
SLQ + E+L +V+ ENS+ EK+ SHP L ++ + + T+
Sbjct: 153 SLQSLGEELSSVSPSENSDYAPNPSRSEKLILDVQPSHPGLLNYSPYENVCKISGSS-TD 211
Query: 391 FLKL---QVIEQQNIID-ELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET 446
F K ++ +D E+ REKL + R+ ++ F + S
Sbjct: 212 FQKKPRDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRA 271
Query: 447 S-SMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDA 505
SM + + P L+E + E+E+ + + + L+ A L++ +I
Sbjct: 272 KVSMLESAQQQAASVPI--LEEQIINLEAEV-----SAQDKVLREAENKLEQSQKMVI-- 322
Query: 506 EREAKAQEQLQAEVLRYKAKIEDLEATLA------QKGQDSHWVED-KQLFIKRNQELLE 558
E+E QE + + K K++ LE T Q+ + + E+ + F + +++ E
Sbjct: 323 EKEQSLQESKEECI---KLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAE 379
Query: 559 KIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIY 618
K+EK +AE L++ L + +N+ L+ R G+ ++
Sbjct: 380 KLEKVQAEEEILERNLTNCEKENKRLQER----------------------CGLYKSELE 417
Query: 619 CMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLS-LAE------KWIQQIE 671
+KE ++ + +N N + + ++ ++ S V++ L E K ++E
Sbjct: 418 ILKEKLRQLK-----------EENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELE 466
Query: 672 GAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQET 731
+ L K + + E ++ E LD +Q ++ + + ++ LE + +
Sbjct: 467 NKDEILRDKFSLMNENRELKVRVAAQ-NERLDLCQQEIESSRVELRSLEKIISQLPLKRE 525
Query: 732 VIKFGELLSEKQ 743
+ F LS+ Q
Sbjct: 526 LFGFKSYLSKYQ 537
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 96.7 bits (239), Expect = 8e-20
Identities = 185/949 (19%), Positives = 380/949 (40%), Gaps = 189/949 (19%)
Query: 18 ALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVL---VTELK 74
A +A + + +K+ ++ L + + ++ + +EK +E KR++E Q + L E+
Sbjct: 1559 AKDSALQSIESKMLELTNRLQESQEEIQIMIKEK-EEMKRVQEALQIERDQLKENTKEIV 1617
Query: 75 AKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDG-EIQRLKSALCALRDGSSDKVRTAL 133
AK+ E + KE Q ++ + + +++M +++ E Q+L L + ++ +R
Sbjct: 1618 AKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLN-----LENIETENIRLTQ 1672
Query: 134 TIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEH---QS 190
+ E + ER L LK + Q+ E L I D K +L+ H +
Sbjct: 1673 ILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKE 1732
Query: 191 HQEAISKIKW----------ESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ 240
HQE I K++ ++D+ D +KA+D +++EL ++++ Q
Sbjct: 1733 HQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQD---LKIQEELRIAHMHLKE---Q 1786
Query: 241 KEALDEQLFLVKEAECNMSSPKREIPG------------RAGDGSEHCSSPDLRRNQKRI 288
+E +D+ +V E +S+ ++++ +A + D+ QK++
Sbjct: 1787 QETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKV 1846
Query: 289 AEL----------NATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRND 338
+E+ + T+ KLE N L + +E L+ ++ K+ L + L D
Sbjct: 1847 SEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERD 1906
Query: 339 ELMVSLQ-------RMEEKLKA---VTKENSE----MREKIT---------------SHP 369
+L SLQ ++++LK ++KE+ E +REKI+ S
Sbjct: 1907 QLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKD 1966
Query: 370 PLKKL----------------------KSLNDLDQANEEQETEFLKLQVIEQQNI----- 402
L+K K +N+++Q ++ E + L +Q + N
Sbjct: 1967 ELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKK 2026
Query: 403 IDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPD 462
+ E + + + R R K + D FI + + + + R +
Sbjct: 2027 LHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQ 2086
Query: 463 DDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEV--- 519
L ESL E R ++L K Y + Y L + +D E+E + Q++L V
Sbjct: 2087 QHLTESL--REKCSRIKELLKRYSEMDDHYECLNRLS---LDLEKEIEFQKELSMRVKAN 2141
Query: 520 --LRY--KAKIEDLEATLAQKGQDSHWVEDKQLFI----------------KRNQELLEK 559
L Y IE L + + H + K ++ K + +++
Sbjct: 2142 LSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDE 2201
Query: 560 IEKQEAENHRLQ----------QELQDAR-DQNELLEFRNLELEERERRSPPFNLQIHPF 608
+EKQ+ ++Q +EL+D + +QN L + + E P +
Sbjct: 2202 VEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQV 2261
Query: 609 SDGVSAL------------QIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQA 656
+ I +K G++ N D I Q++ N N +AI+
Sbjct: 2262 LSNRKEMTQFLEEWLNTRFDIEKLKNGIQKEN--DRICQVN------NFFNNRIIAIMNE 2313
Query: 657 STVL-----SLAEKWIQQIEGAE---AALHQKMMELESDMEQFCKIKGYLEEELD--YRK 706
ST +++++W Q ++ + L + L++ + ++ ++ +
Sbjct: 2314 STEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTS 2373
Query: 707 QALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQM------LR 760
+A +I+ELE +L+ A + + + +K+ E + KL+ ++ L
Sbjct: 2374 RATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLE 2433
Query: 761 KSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIK-DLEEKSNRK 808
K++E Q+LQ+++ L + ++ E+ D++ + +K DLE+ N K
Sbjct: 2434 KTKE-TIQVLQDKVALGAKPYK-----EEIEDLKMKLVKIDLEKMKNAK 2476
Score = 95.9 bits (237), Expect = 1e-19
Identities = 187/887 (21%), Positives = 370/887 (41%), Gaps = 128/887 (14%)
Query: 23 NEDLRTKLTDIQIELHQEKSKVSKLERE---KTQEAK-RIRELEQRKHTVLVTELKAKLH 78
NE + ++ ++ E + S + L+ E KTQE + + RE+++R + + +LK +L
Sbjct: 840 NERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEM--EQLKEQL- 896
Query: 79 EEKMKELQAVR--ENLIKQHEQEMSRTVKVRDGE---IQRLKSALCALRDGSSDKVRTA- 132
E + LQ V + LI + Q+ VK E +++L+ +L RD +
Sbjct: 897 ENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTV 956
Query: 133 -LTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSH 191
+ I+ +E+ R E LK QE + T K ++ E +S + ++ G+ + E Q
Sbjct: 957 NMNIDTQEQLRNAL--ESLKQHQET--INTLKSKISEEVSRNLHMEE-NTGETKDEFQQK 1011
Query: 192 QEAISKIKWESERDIRRLMDEIKAKD-----RIIFSLEKELETQTGYVQKLQLQKEAL-- 244
I K + ++ + L ++K + R IFSL +E ++ + +KE L
Sbjct: 1012 MVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKT 1071
Query: 245 ------------DEQLFLV----KEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRI 288
E+L L+ K+ + ++ K + G+ S C L ++++
Sbjct: 1072 DLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDR--LAEVEEKL 1129
Query: 289 AELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRME 348
E + +++ + + + +E +E+ K++ E E L + L E + Q++
Sbjct: 1130 KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLN 1189
Query: 349 E---KLKAVTKENSEMREKITSHPPLKK-LKSLNDLDQANEEQETEFLKLQVI---EQQN 401
E ++K++TKE ++E S + L+ +A Q E LK+ I E Q
Sbjct: 1190 ENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQE 1249
Query: 402 IIDELTRD----REKLIRRRKHRRSSKPIKR--PVL----DPFIGYDEDSMDSETSSMAS 451
IDEL R ++I + +S ++ PVL + E S ET +
Sbjct: 1250 TIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELE 1309
Query: 452 FRTDRTPATPDDDLDE--------SLAAEESELRFRQLTKEYQALQRAYALLQEQTGGII 503
T+++ L + +ES+ + LTKE L+ L+ + +
Sbjct: 1310 LLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLK 1369
Query: 504 DAERE--AKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLF------------ 549
+ RE AK QE + K +D E T + +D L
Sbjct: 1370 EHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKR 1429
Query: 550 IKRNQELLEKIEKQEAENHRLQQELQDARDQ-----NELLEFRNLELEERERRSPPFNLQ 604
++ + + ++ + K++ + RLQ+ LQ DQ E++ ++LE EE + + +
Sbjct: 1430 LQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVA-KHLETEEELKVA---HCC 1485
Query: 605 IHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRN--------EEQVAIIQA 656
+ + ++ L++ + K+ I + KQL+ + D L+N EEQ I Q
Sbjct: 1486 LKEQEETINELRVNLSE---KETEISTIQKQLEAINDK--LQNKIQEIYEKEEQFNIKQI 1540
Query: 657 STVLSLAEKWIQQIEGAEA------ALHQKMMELES--------------DMEQFCKIKG 696
S V + Q E +A ++ KM+EL + + E+ +++
Sbjct: 1541 SEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQE 1600
Query: 697 YLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRR 756
L+ E D K+ + +++E + Y L+ V + E + E + + + +KL
Sbjct: 1601 ALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNL 1660
Query: 757 QMLRKSREYDCQILQERMELLQQAHQR---IRDLEDKTDIQKRQIKD 800
+ + QIL E +E ++ + +R +E+ +++ Q+K+
Sbjct: 1661 ENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKE 1707
Score = 84.3 bits (207), Expect = 4e-16
Identities = 194/915 (21%), Positives = 370/915 (40%), Gaps = 189/915 (20%)
Query: 9 GEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLERE---------KTQEAKRIR 59
G+ P+ L+ N +L K+TD+Q EL++E + L E E +R+R
Sbjct: 706 GKVPKDLL-----CNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLR 760
Query: 60 ELEQRKHTVL--VTELKAKLHEE----------------KMKELQAVRENLIKQHEQE-- 99
+ Q K L +T K KL E K K+ A ++ K +QE
Sbjct: 761 KEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQ 820
Query: 100 ----------------------MSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEA 137
M++ + E Q+ S+L AL+ S K + L +
Sbjct: 821 NFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQ-ELQEKT 879
Query: 138 REEARKLFDTERL-----------------------KLLQEIADLKTAKKQVDEAL---- 170
RE +L + E+L KL Q + ++KT ++ D+
Sbjct: 880 REVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQE 939
Query: 171 SNMIQADKIKAG-------------DLRSEHQS---HQEAI----SKIKWESERDIRRLM 210
S I+ D++K+ LR+ +S HQE I SKI E R++
Sbjct: 940 SLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEE 999
Query: 211 DEIKAKDRI---IFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPG 267
+ + KD + ++K+ + + Q L + D ++ + ++ K E+
Sbjct: 1000 NTGETKDEFQQKMVGIDKKQDLEAKNTQ--TLTADVKDNEIIEQQRKIFSLIQEKNELQQ 1057
Query: 268 RAGD--GSEHCSSPDLRRNQKRIAELNATIRKLED----RNTLLGDERNELLKRVRETEK 321
+ DL+ N + E +R L D + ++ E+N +K+ E +
Sbjct: 1058 MLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSR 1117
Query: 322 QCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLD 381
C L E + L +++ + LQ +++L V +E SEM++KI LK L + +
Sbjct: 1118 TCDRLAEVEEKLKEKSQQ----LQEKQQQLLNVQEEMSEMQKKINEIENLK--NELKNKE 1171
Query: 382 QANEEQETEFLKL--QVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDE 439
E ETE L+L ++ E + +T++R+ L K + S +R L +I E
Sbjct: 1172 LTLEHMETERLELAQKLNENYEEVKSITKERKVL----KELQKSFETERDHLRGYIREIE 1227
Query: 440 DS--MDSETSSMASFRTDRTPATPDDDLDESLAAEESE-LRFRQLTKEYQALQRAYALLQ 496
+ E +A T D+L S++ + ++ + + L K + LQ +L
Sbjct: 1228 ATGLQTKEELKIAHIHLKEHQET-IDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLH 1286
Query: 497 EQTGGIIDAEREAKAQEQL-QAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQE 555
E+ + + + ++ QE + + E+L ++ +D TLA+ +E ++L
Sbjct: 1287 EEQELLPNVKEVSETQETMNELELLTEQSTTKD-STTLAR-------IEMERL------R 1332
Query: 556 LLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSAL 615
L EK ++ + E L +E + + E LE ++ +L+E R + ++ +
Sbjct: 1333 LNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRET-------------LAKI 1379
Query: 616 QIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEA 675
Q K+ + +N+ + ++ E I+ + + +IE
Sbjct: 1380 QESQSKQ-EQSLNMKE--------------KDNETTKIVSEMEQFKPKDSALLRIEIEML 1424
Query: 676 ALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKF 735
L +++ E +M+ K K L+ + + DQ I+E+ A L+ E +K
Sbjct: 1425 GLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVA---KHLETEEELKV 1481
Query: 736 GELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMEL----LQQAHQRIRDLEDKT 791
++Q+E + +LR + K E + +Q+++E LQ Q I + E++
Sbjct: 1482 AHCCLKEQEE----TINELRVNLSEK--ETEISTIQKQLEAINDKLQNKIQEIYEKEEQF 1535
Query: 792 DIQKRQIKDLEEKSN 806
+I +QI +++EK N
Sbjct: 1536 NI--KQISEVQEKVN 1548
Score = 83.6 bits (205), Expect = 7e-16
Identities = 179/878 (20%), Positives = 357/878 (40%), Gaps = 156/878 (17%)
Query: 37 LHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQH 96
L+QE + S+L + + + EQ + ELK K + + E +A+ K
Sbjct: 491 LNQENIE-SELNSLRADYDNLVLDYEQLRTEKEEMELKLK-EKNDLDEFEALERKTKKDQ 548
Query: 97 EQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKL---FDTERLK-- 151
E ++ + ++ + L + S KV L E ++ +KL D+++L+
Sbjct: 549 EMQLIHEISNLKNLVKHAEVYNQDLENELSSKVE--LLREKEDQIKKLQEYIDSQKLENI 606
Query: 152 ------LLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKW---ES 202
L+ I D K K+ + +A + + A K ++ LRSE+ +E + ++ +
Sbjct: 607 KMDLSYSLESIEDPKQMKQTLFDAETVALDA-KRESAFLRSENLELKEKMKELATTYKQM 665
Query: 203 ERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKL-QLQKEALDEQLFLVKEAECNMSSP 261
E DI+ +++AK ++ LEKEL++ + KL L + + L E E ++
Sbjct: 666 ENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDL 725
Query: 262 KREIPGRAGDG----SEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVR 317
++E+ + E +L+ + L I+ + ++ E+++L V
Sbjct: 726 QKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVV 785
Query: 318 ETEKQCKPLLERNKCLAKRNDELMVSLQR-----------------MEEKLKAVTKENSE 360
E + + LLE + K D+L + E+K K V +EN
Sbjct: 786 HKESRVQGLLEE---IGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENER 842
Query: 361 MREKITS--------HPPLKKLKS-------------------LNDLDQANEEQETEFLK 393
M ++I + L LK+ LN+++Q E+ E
Sbjct: 843 MNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDST 902
Query: 394 LQVIEQQNI------------IDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDS 441
LQ +E++ + LT++++ L K + S I+R L I D+
Sbjct: 903 LQTVEREKTLITEKLQQTLEEVKTLTQEKDDL----KQLQESLQIERDQLKSDI---HDT 955
Query: 442 MDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGG 501
++ + R + +L ++ SE R L E + Q+ G
Sbjct: 956 VNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI 1015
Query: 502 IIDAEREAKAQEQLQA-----EVLRYKAKI-----------EDLEATLAQKGQ-DSHWVE 544
+ EAK + L A E++ + KI + LE+ +A+K Q + E
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075
Query: 545 DKQLFIKRNQELL---EKIEKQ-----EAENHRLQQELQDARDQNELLEFRNLELEERER 596
+ ++ I+ +EL ++++KQ + +NH +++E + +R + L E +L+E+ +
Sbjct: 1076 NIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEE-KLKEKSQ 1134
Query: 597 RSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQA 656
+ Q+ + +S +Q K +N + NL+NE
Sbjct: 1135 QLQEKQQQLLNVQEEMSEMQ--------KKIN------------EIENLKNE-------- 1166
Query: 657 STVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRI 716
L E ++ +E L QK+ E +++ K + L+E + D I
Sbjct: 1167 ---LKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYI 1223
Query: 717 QELEATLYNALQQETVIKFGELLSEKQQE---ELRTAVEKLRRQMLR-KSREYDCQILQE 772
+E+EAT LQ + +K + ++ QE ELR +V + Q++ + E LQE
Sbjct: 1224 REIEAT---GLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQE 1280
Query: 773 RMELLQQAHQRIRDLEDKTDIQK--RQIKDLEEKSNRK 808
+ +L + + + ++++ ++ Q+ +++ L E+S K
Sbjct: 1281 EIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTK 1318
Score = 44.7 bits (104), Expect = 4e-04
Identities = 63/274 (22%), Positives = 121/274 (44%), Gaps = 43/274 (15%)
Query: 29 KLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLHE-----EKMK 83
K+ +++ LH+ K E ++ K +ELE ++ +L+AK+HE EK K
Sbjct: 2382 KIRELENSLHEAKESAMHKE---SKIIKMQKELEVTND--IIAKLQAKVHESNKCLEKTK 2436
Query: 84 ELQAVRENLI----KQHEQEMSRT-VKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAR 138
E V ++ + K +++E+ +K+ +++++K+A ++ + T T+E +
Sbjct: 2437 ETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNA----KEFEKEISATKATVEYQ 2492
Query: 139 EEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQA--------DKIKAGDLRSEHQS 190
+E +L E L+ Q+ D + D SN KA L+SEH
Sbjct: 2493 KEVIRLL-RENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIR 2551
Query: 191 HQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFL 250
++ ISK+K ++E+ IK K+ ++ S + L + ++ L++EA
Sbjct: 2552 LEKEISKLKQQNEQ-------LIKQKNELL-SNNQHLSNEVKTWKERTLKREA------- 2596
Query: 251 VKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRN 284
K+ C S ++ G A + S RN
Sbjct: 2597 HKQVTCENSPKSPKVTGTASKKKQITPSQCKERN 2630
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 95.1 bits (235), Expect = 2e-19
Identities = 178/883 (20%), Positives = 364/883 (41%), Gaps = 167/883 (18%)
Query: 7 NKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR-K 65
+K E +A+ + LQ ++L+ ++ ++ E+ E++ +K E++++ ++ + E+ +R +
Sbjct: 1095 SKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLE 1154
Query: 66 HTVLVTELKAKLHEEKMKELQAVRENLIK---QHEQEMSRTVKVRDGEIQRLKSALCALR 122
T + +L++++ E Q +R +L + QHE + + ALR
Sbjct: 1155 EAGGATSAQVELNKKREAEFQKLRRDLEEATLQHE------------------AMVAALR 1196
Query: 123 DGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAG 182
+D + E ++ + +R+K Q++ K+ K + LS+ +A G
Sbjct: 1197 KKHADSMA--------ELGEQIDNLQRVK--QKLEKEKSELKMETDDLSSNAEAISKAKG 1246
Query: 183 DLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRI---IFSLEKELETQTGYVQKLQL 239
+L +S ++ +S++K + E R + D + R+ ++L+ + V +L
Sbjct: 1247 NLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSR 1306
Query: 240 QKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCS--SPDLRRNQKRIAELNATIRK 297
K+A +Q+ +K + K + C Q+ AEL + K
Sbjct: 1307 SKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1366
Query: 298 LED---------------RNTLLGDERNELLKRVRETEK-------QCKPLLERNKCLAK 335
R L + + +L +R++E E+ +C L + + L
Sbjct: 1367 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQN 1426
Query: 336 RNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQE---TEFL 392
++LM+ ++R A+ K+ +K+ S K ++ +L+ + +E TE
Sbjct: 1427 EVEDLMLDVERSNAACAALDKKQRNF-DKVLSEWKQKYEETQAELEASQKESRSLSTELF 1485
Query: 393 KLQVI-------------EQQNIIDELTRDREKLIRRRKHRRSSKPIKRPV------LDP 433
K++ + E +N+ E++ E++ K + IK+ V +
Sbjct: 1486 KVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQA 1545
Query: 434 FIGYDEDSMDSETSSMASFR---------TDRTPATPDDDLDESLAAEESELRFRQLTKE 484
+ E S++ E + + DR A D+++D+ + Q T +
Sbjct: 1546 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLD 1605
Query: 485 YQALQRAYALL--QEQTGGIIDAEREAKAQEQLQAEVLR-YK-----AKIEDLEATLAQK 536
+ R AL ++ G + + E + +L AE LR Y+ K L A +
Sbjct: 1606 AEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALR 1665
Query: 537 GQDSHWVEDKQLFIKRNQELLEK--------IEKQEAENHRLQQELQDARDQNELLEFRN 588
GQ+ ++++ ++R LL+ +E+ E +QEL DA ++ +LL +N
Sbjct: 1666 GQED--LKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQN 1723
Query: 589 LELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNE 648
L +++ + VS LQ + ++I++ RN
Sbjct: 1724 TSLINTKKK----------LENDVSQLQ----------SEVEEVIQE---------SRNA 1754
Query: 649 EQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQ- 707
E+ A + +AE+ +++ + A L + LE ++ L+ LD +Q
Sbjct: 1755 EEKAKKAITDAAMMAEE-LKKEQDTSAHLERMKKNLEQTVKD-------LQHRLDEAEQL 1806
Query: 708 ALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDC 767
AL +IQ+LEA + L+ E E +Q+ AV+ LR+ R+ +E
Sbjct: 1807 ALKGGKKQIQKLEARV-RELEGEV---------ENEQKRNAEAVKGLRKHE-RRVKELTY 1855
Query: 768 QILQERMELLQQAHQRIRDLEDKTDIQ----KRQIKDLEEKSN 806
Q ++R +L R++DL DK + KRQ ++ EE+SN
Sbjct: 1856 QTEEDRKNVL-----RLQDLVDKLQAKVKSYKRQAEEAEEQSN 1893
Score = 88.2 bits (217), Expect = 3e-17
Identities = 170/867 (19%), Positives = 346/867 (39%), Gaps = 117/867 (13%)
Query: 4 KGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIREL-- 61
K K ++ E +V L DL+ ++ L + + +L + K Q +I+E+
Sbjct: 868 KSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTE 927
Query: 62 ---EQRKHTVLVTELKAKLHEE----------------KMKELQAVRENLIKQHEQEMSR 102
E+ + +T K KL +E K+++ + EN +K +EM+
Sbjct: 928 RAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG 987
Query: 103 TVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTA 162
D I +L AL++ +T ++A E+ + + KL Q++ DL+ +
Sbjct: 988 L----DETIAKLSKEKKALQETHQ---QTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGS 1040
Query: 163 KKQVDEALSNMIQADKIKAGDLRSEHQS-------HQEAISKIKWESERDIRRLMDEIKA 215
+Q + ++ +A + GDL+ +S Q+ K++ + E +I L+ +I+
Sbjct: 1041 LEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLE-KKEFEISNLISKIED 1099
Query: 216 KDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEH 275
+ + L+K+++ +++L + EA ++ ++S EI R +
Sbjct: 1100 EQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG-G 1158
Query: 276 CSSPDLRRNQKRIAELNATIRKLED----RNTLLGDERNELLKRVRETEKQCKPLLERNK 331
+S + N+KR AE R LE+ ++ R + + E +Q L +
Sbjct: 1159 ATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQ 1218
Query: 332 CLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITS-HPPLKKLKS--------LNDLDQ 382
L K EL + + +A++K + + S + +LK+ +NDL
Sbjct: 1219 KLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTA 1278
Query: 383 ANEEQETEF--LKLQVIEQQNIIDELTRDRE---KLIRRRKHRRSSKPIKRPVLDPFIGY 437
+TE Q+ E+ ++ +L+R ++ + I KH+ + + L +
Sbjct: 1279 QRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQS 1338
Query: 438 DEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQE 497
D + + +L +L+ SE+ + E A+QR L +
Sbjct: 1339 SRHDCDLLREQYEEEQEGKA------ELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1392
Query: 498 QTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELL 557
+ A+R +A+E ++A AK LE T K + + VED L ++R+
Sbjct: 1393 KKK---LAQRLQEAEEHVEA----VNAKCASLEKT---KQRLQNEVEDLMLDVERSNAAC 1442
Query: 558 EKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQI 617
++K++ ++ E + ++ + LE ++E RS L F
Sbjct: 1443 AALDKKQRNFDKVLSEWKQKYEETQ----AELEASQKESRS----LSTELFK-------- 1486
Query: 618 YCMKEGVKDVNIPDLIKQLDILGDNGNLRNE-----EQVAIIQASTVLSLAEKWIQQIEG 672
VK+V L + + +N NL+ E EQ+A + + EK +Q+E
Sbjct: 1487 ------VKNVYEESLDQLETLRRENKNLQQEISDLTEQIA--EGGKQIHELEKIKKQVEQ 1538
Query: 673 AEAALHQKMMELESDME-----------QFCKIKGYLEEELDYRKQALDQAYMRIQELEA 721
+ + + E E+ +E + ++K ++ ++ + + +DQ +
Sbjct: 1539 EKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVE 1598
Query: 722 TLYNALQQETVIKFGELLSEKQQE----ELRTAVEKLRRQMLRKSREY--DCQILQERME 775
T+ + L E + L +K+ E E+ + R R Y IL+E
Sbjct: 1599 TMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQL 1658
Query: 776 LLQQAHQRIRDLEDKTDIQKRQIKDLE 802
L A + DL+++ I +R+ L+
Sbjct: 1659 HLDDALRGQEDLKEQLAIVERRANLLQ 1685
Score = 69.3 bits (168), Expect = 1e-11
Identities = 141/695 (20%), Positives = 285/695 (41%), Gaps = 109/695 (15%)
Query: 128 KVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSE 187
K++ L E+ E K E+A + +K+++E + +++ + DL+ +
Sbjct: 838 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLK----EKNDLQLQ 893
Query: 188 HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQ 247
QS ++++ + E+ I+ + LE +++ T E +E+
Sbjct: 894 VQSEADSLADAEERCEQLIKNKIQ-----------LEAKIKEVT----------ERAEEE 932
Query: 248 LFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLLGD 307
+E +++ KR++ + CS +K I +L T+ K+E +
Sbjct: 933 ----EEINAELTAKKRKL-------EDECSEL-----KKDIDDLELTLAKVEKEKHATEN 976
Query: 308 ERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITS 367
+ L + + ++ L + K L + + + + LQ E+K+ +TK +++ +++
Sbjct: 977 KVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDD 1036
Query: 368 -HPPLKKLKSLN-DLDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRR--RKHRRSS 423
L++ K L DL++A + E + LKL Q++ +D + D+++L + +K S
Sbjct: 1037 LEGSLEQEKKLRMDLERAKRKLEGD-LKL---AQESTMD-MENDKQQLDEKLEKKEFEIS 1091
Query: 424 KPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTK 483
I + DE +++ + R ++ E + ++E + L++
Sbjct: 1092 NLISKI-------EDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSR 1144
Query: 484 EYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLE-----ATLAQKGQ 538
E + + E+ GG A+ E + + + + LR + L+ A L +K
Sbjct: 1145 ELEEISERL----EEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHA 1200
Query: 539 DSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRS 598
DS +Q I Q + +K+EK+++E L+ E D E + LE+ R
Sbjct: 1201 DSMAELGEQ--IDNLQRVKQKLEKEKSE---LKMETDDLSSNAEAISKAKGNLEKMCR-- 1253
Query: 599 PPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQAST 658
D VS L+ KE + I DL Q R Q + S
Sbjct: 1254 --------SLEDQVSELK---TKEEEQQRLINDLTAQ----------RARLQTEAGEYSR 1292
Query: 659 VLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALD---QAYMR 715
L + + Q+ ++ A Q++ EL+ +E+ K K L L + D + Y
Sbjct: 1293 QLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEE 1352
Query: 716 IQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRR-QMLRKSREYDCQILQERM 774
QE +A L AL + SE Q + + ++R + L ++++ Q LQE
Sbjct: 1353 EQEGKAELQRALSKAN--------SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1404
Query: 775 ELLQQAHQRIRDLEDKTDIQKRQIKDL---EEKSN 806
E ++ + + LE + +++DL E+SN
Sbjct: 1405 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSN 1439
Score = 62.0 bits (149), Expect = 2e-09
Identities = 122/683 (17%), Positives = 261/683 (38%), Gaps = 109/683 (15%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIREL---- 61
+ K E+ + LI L A L+T+ + +L ++ + VS+L R K ++I EL
Sbjct: 1263 KTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQL 1322
Query: 62 --EQRKHTVLVTELKAKLHE---------------------------------------- 79
E + L L++ H+
Sbjct: 1323 EEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDA 1382
Query: 80 -EKMKELQAVRENLIK--QHEQEMSRTVKVRDGEIQRLKSALC-ALRDGSSDKVRTALTI 135
++ +EL+ ++ L + Q +E V + +++ K L + D D R+
Sbjct: 1383 IQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAAC 1442
Query: 136 EAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAI 195
A ++ ++ FD + Q+ + + A+ + + S + + K ++ E E +
Sbjct: 1443 AALDKKQRNFDKVLSEWKQKYEETQ-AELEASQKESRSLSTELFKVKNVYEESLDQLETL 1501
Query: 196 SKIKWESERDIRRLMDEIKAKDRIIFSLEK---ELETQTGYVQKLQLQKEA-LDEQLFLV 251
+ +++I L ++I + I LEK ++E + +Q + EA L+ + +
Sbjct: 1502 RRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKI 1561
Query: 252 KEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAE-----LNATIRKLED----RN 302
+ ++ K E+ + + E L+RN R+ E L+A IR D +
Sbjct: 1562 LRIQLELNQVKSEVDRKIAEKDEEIDQ--LKRNHTRVVETMQSTLDAEIRSRNDALRVKK 1619
Query: 303 TLLGDERN-------------ELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEE 349
+ GD E L+ R T+ K + ++L L +E
Sbjct: 1620 KMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVER 1679
Query: 350 KLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQ----QNIIDE 405
+ + E E+ + +K+ LD + Q +I +N + +
Sbjct: 1680 RANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQ 1739
Query: 406 LTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDL 465
L + E++I+ + R + + K+ + D + +E + +TS+ + +
Sbjct: 1740 LQSEVEEVIQ--ESRNAEEKAKKAITDAAMMAEELKKEQDTSAHL------------ERM 1785
Query: 466 DESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAK 525
++L +L+ R E AL+ +Q+ + + E E + +++ AE ++ K
Sbjct: 1786 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRK 1845
Query: 526 IEDLEATLAQKGQDSH--------WVEDKQLFIKRNQELLEKIEKQEAEN----HRLQQE 573
E L + ++ V+ Q +K + E+ E+Q N +LQ E
Sbjct: 1846 HERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHE 1905
Query: 574 LQDARDQNELLEFRNLELEERER 596
L++A ++ ++ E + +L + R
Sbjct: 1906 LEEAEERADIAESQVNKLRVKSR 1928
Score = 33.9 bits (76), Expect = 0.62
Identities = 36/176 (20%), Positives = 77/176 (43%), Gaps = 13/176 (7%)
Query: 646 RNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKI-------KGYL 698
+N+ Q+ + + L+ AE+ +Q+ + L K+ E+ E+ +I K L
Sbjct: 887 KNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKL 946
Query: 699 EEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQM 758
E+E K+ +D + + ++E + + V E ++ + + + EK Q
Sbjct: 947 EDECSELKKDIDDLELTLAKVEKEKHAT--ENKVKNLTEEMAGLDETIAKLSKEKKALQE 1004
Query: 759 LRKSREYDCQILQERMELLQQA----HQRIRDLEDKTDIQKRQIKDLEEKSNRKHG 810
+ D Q ++++ +L +A Q++ DLE + +K+ DLE + G
Sbjct: 1005 THQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG 1060
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 93.6 bits (231), Expect = 7e-19
Identities = 189/872 (21%), Positives = 369/872 (42%), Gaps = 132/872 (15%)
Query: 13 EALIVALQAANEDLRTKLTDIQIELHQEKS----KVSKLEREKTQEAKRI---------- 58
E++ ++ +EDL +L + + +EK K+ L REK + I
Sbjct: 2110 ESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKK 2169
Query: 59 -RELEQRKHTVLVTELKAKLHEEKMKELQAVRENLI---KQHEQEMSRTVKVRDGEIQRL 114
+E++Q + + T + + M LQ R+ +I K+ E++ S ++ ++ EI RL
Sbjct: 2170 DKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEI-RL 2228
Query: 115 KSALCA-----LRDGSSDKVRTALTIEAREEARKLFDTE---RLKLLQEIADLKTAKKQV 166
K C+ LR S + I E +++++++ ++L Q++ D T + +
Sbjct: 2229 KEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCD--TLQGEN 2286
Query: 167 DEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKE 226
E LS + + R + S Q ++K+ E +++ L D++ SLEK
Sbjct: 2287 KELLSQLEET--------RHLYHSSQNELAKL----ESELKSLKDQLTDLSN---SLEKC 2331
Query: 227 LETQTGYVQKLQLQKEA-LDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQ 285
E Q G ++ + Q+EA + F ++ E ++ + RE+ R + + Q
Sbjct: 2332 KE-QKGNLEGIIRQQEADIQNSKFSYEQLETDLQA-SRELTSRLHEEIN-------MKEQ 2382
Query: 286 KRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQ 345
K I+ L+ K E + + R + K ++E E E N L + N + +
Sbjct: 2383 KIISLLSG---KEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTN 2439
Query: 346 RMEEKLKAVTKENSEMREKITSHPPLKKLKSL-NDLDQ-ANEEQETEFLKLQVI-EQQNI 402
++ E LK + KEN + + ++ S +K + SL ND D+ + Q+ E L +I E+ +
Sbjct: 2440 QLMETLKTIKKENIQQKAQLDSF--VKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQL 2497
Query: 403 IDELTRDREKL---IRRRKHRRSSKPIKRPVLD-PFIGYDED------SMDSETSSMASF 452
I E + KL IR + + LD I Y ED DS+ +
Sbjct: 2498 IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV 2557
Query: 453 RTDRTP------ATPDDDLDESLAAEESELRF--------RQLTKEYQAL--------QR 490
+ + A ++ L ES A E R + L+KE ++L ++
Sbjct: 2558 QLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQ 2617
Query: 491 AYALLQEQTGGIIDAEREAKAQE--QLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQL 548
AL +E T G+ A+ + K +E +L A + +I +LE L +++
Sbjct: 2618 VTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEA-------- 2669
Query: 549 FIKRNQELLEKIEKQEAENHR----LQQELQDARDQNELLEFRNLELEER----ERRSPP 600
K+ E+ +K++K+ H ++ E + A ++ L +E+E++ + +
Sbjct: 2670 -AKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKG 2728
Query: 601 FNLQIHPFSDGVSALQIYCMKEGVKDVNIPDL-------IKQLDILGDNGNLRNEEQVAI 653
QI F +S+LQ + + +L +K+L L + G L E +
Sbjct: 2729 LTAQIQSFGRSMSSLQ---NSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALL 2785
Query: 654 IQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAY 713
+ + ++ E E + + L + +L S EQ + LE+ + + Q+ +A
Sbjct: 2786 SETAFSMNSTE------ENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYN-QVQSFSKAM 2838
Query: 714 MRIQELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQER 773
+Q L+N L++ + G+ S Q V+ L++ M S + D L +
Sbjct: 2839 ASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAM--SSLQNDRDRLLKE 2896
Query: 774 MELLQQAHQRIRDLEDKTDIQKRQIKDLEEKS 805
++ LQQ + +I + K Q+++ ++K+
Sbjct: 2897 LKNLQQQYLQINQEITELHPLKAQLQEYQDKT 2928
Score = 88.2 bits (217), Expect = 3e-17
Identities = 184/856 (21%), Positives = 352/856 (41%), Gaps = 128/856 (14%)
Query: 11 KPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLV 70
K EA+ VA+ + ++ +++ L QE+ + LE E + + +L + T+
Sbjct: 2391 KEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKK 2450
Query: 71 TELKAKLHEEK----MKELQAVRENLIKQHEQ----------EMSRTVKVRDGEIQRLKS 116
++ K + M LQ R+ ++ ++Q E + ++ E +LK
Sbjct: 2451 ENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKE 2510
Query: 117 ALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAK-KQVDEALSNMIQ 175
+ LR D E KL D E ++ +++ + T K Q + L +Q
Sbjct: 2511 EIRGLRSHMDD---------LNSENAKL-DAELIQYREDLNQVITIKDSQQKQLLEVQLQ 2560
Query: 176 ADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQ 235
+K +L +++ +E + + + E+ D+RR + ++ + + L KE+E+ +
Sbjct: 2561 QNK----ELENKYAKLEEKLKESE-EANEDLRRSFNALQEEKQ---DLSKEIESLKVSIS 2612
Query: 236 KLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATI 295
+L Q AL E+ L + + E+ H S +QKRIAEL +
Sbjct: 2613 QLTRQVTALQEEGTLGLY-HAQLKVKEEEV---------HRLSALFSSSQKRIAELEEEL 2662
Query: 296 RKLE-DRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAV 354
++ + +G+ ++L K ++ + + +R EL L ME+KL V
Sbjct: 2663 VCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMV 2722
Query: 355 TKENSEMREKITSHPPLKKLKSL-NDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKL 413
TKEN + +I S + + SL N D ANEE +DEL
Sbjct: 2723 TKENKGLTAQIQSFG--RSMSSLQNSRDHANEE----------------LDEL------- 2757
Query: 414 IRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETS-SMASFRTDRTPATPDDDLDESLAAE 472
+RK+ S K + + + + D++ SET+ SM S T+ + + L++ L ++
Sbjct: 2758 --KRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNS--TEENSLSHLEKLNQQLLSK 2813
Query: 473 ESELRF--RQLTKEY---QALQRAYALLQEQTGGI-IDAEREAKAQEQLQ---AEVLRYK 523
+ +L QL Y Q+ +A A LQ + + + E+ K++E Q A+
Sbjct: 2814 DEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSP 2873
Query: 524 AKIEDLEATLAQKGQDSHWVEDKQL-FIKRNQELLEKIEKQEAENHRLQQELQDARDQNE 582
A+++ L+ ++ D D+ L +K Q+ +I ++ E H L+ +LQ+ +D+ +
Sbjct: 2874 AEVQSLKKAMSSLQND----RDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTK 2929
Query: 583 LLEFRNLELEERERRSPPFNLQIHPFSDGVSALQI--------YCMKEGVKDVNIPDLIK 634
+ EE + + + ++H S+ +I Y M KD + L
Sbjct: 2930 AFQIMQ---EELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQN 2986
Query: 635 QLDILGDNGNLRNEEQVAI-IQASTVLSLAEKWIQ-----------QIEGAEAALHQK-- 680
+ L + + +V QAS S + Q Q+ + +HQK
Sbjct: 2987 LIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKEL 3046
Query: 681 -MMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGEL- 738
+ +L S+ Q + K L +L Q+L + +L +Q ++ G L
Sbjct: 3047 RIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLN 3106
Query: 739 -------LSEKQQEELRTAVEKLR--RQMLRKSREYDCQILQERME---LLQQAHQRIRD 786
EK ++ E+LR +Q ++++ C QE E LL++ +
Sbjct: 3107 IDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVA 3166
Query: 787 LEDKTDIQKRQIKDLE 802
E+ + + QI+ LE
Sbjct: 3167 AENALSVAEEQIRRLE 3182
Score = 82.4 bits (202), Expect = 2e-15
Identities = 183/928 (19%), Positives = 375/928 (40%), Gaps = 152/928 (16%)
Query: 8 KGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKT-------QEAKRIRE 60
+ ++ + ++ L E+ +T++ L + +S S E K + K ++E
Sbjct: 1530 QNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKE 1589
Query: 61 LEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQ---EMSRTVKVRDGEIQRLKSA 117
+E K + + + +EK KELQ E L++ +E E R V + Q +
Sbjct: 1590 IESLKSSKIAESTE---WQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQEL 1646
Query: 118 LCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQAD 177
LR ++K T ++ E+ + E + +++ A K K E ++ ++A+
Sbjct: 1647 YGKLRSTEANKKETEKQLQEAEQEME----EMKEKMRKFAKSKQQKILELEEENDRLRAE 1702
Query: 178 KIKAGD--------LRSEHQSHQEAISKIKWESE---RDIRRLMDEIKAKDRIIFSLEKE 226
AGD L S + S +E + ++K E E + + LM E + + L+ +
Sbjct: 1703 VHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQ 1762
Query: 227 LETQTGYVQKLQLQKEALDEQLFLVKEAE--------------------CNMSSP--KRE 264
+E L+ E D Q + +E C+ S P K
Sbjct: 1763 IEGNVSKQANLEAT-EKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSA 1821
Query: 265 IPGRAGDGSEHCSSPDLRRN----QKRIAELNATIRKLEDRNTLLGDERNELLKRVRETE 320
P + D S H + + ++RIA L +K ++ + L +E+N LL ++ +
Sbjct: 1822 NPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKD 1881
Query: 321 KQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLND- 379
+ K L E + N ++ L R+ + + +E ++ E++ + +L LN
Sbjct: 1882 GELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERL-----MNQLAELNGS 1936
Query: 380 -----LDQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPF 434
D + + + E L+ ++ + + EL ++++L++ + S I++ L+
Sbjct: 1937 IGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESE--IRKEYLEKI 1994
Query: 435 IGYDED----SMDSETSSMASFRTDRTPATPDDDL--DESLAAEE---SELRFRQ----- 480
G ++ S E + + D + E ++A E L F Q
Sbjct: 1995 QGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054
Query: 481 ---LTKEYQA-----LQRAYALLQEQTGGIIDAEREA--------KAQEQLQAE----VL 520
+TKE A ++A A L + D + EA K +++LQ+
Sbjct: 2055 DLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKS 2114
Query: 521 RYKAKIEDLEATLAQKGQDSHWVEDKQL-----FIKRNQELLEK--------IEKQEAEN 567
+ K K EDLE L Q ++ H E K + ++R + LE+ + K++ E
Sbjct: 2115 QMKQKDEDLERRLEQ-AEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEV 2173
Query: 568 HRLQQELQD--------ARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYC 619
+LQ+ L + + L + R+ ++E ++ F+ I + + + C
Sbjct: 2174 QQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNC 2233
Query: 620 --MKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAAL 677
+K+ ++ ++I +++L I + L +++Q+ +A T + L +K ++G L
Sbjct: 2234 SVLKDQLRQMSIH--MEELKI--NISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKEL 2289
Query: 678 --------------HQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATL 723
++ +LES+++ L L+ K+ I++ EA +
Sbjct: 2290 LSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADI 2349
Query: 724 YNAL----QQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQ 779
N+ Q ET ++ L+ + EE+ +K+ + K I EL QQ
Sbjct: 2350 QNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAI----AELRQQ 2405
Query: 780 AHQRIRDLEDKTDIQKRQIKDLEEKSNR 807
+ I++LE+ ++ + LEE++ +
Sbjct: 2406 HDKEIKELENLLSQEEEENIVLEEENKK 2433
Score = 79.3 bits (194), Expect = 1e-14
Identities = 174/850 (20%), Positives = 351/850 (41%), Gaps = 108/850 (12%)
Query: 22 ANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTELKAKLH--- 78
++E + +L + + L +EK ++ K +E K I + Q K L ELK +
Sbjct: 1154 SSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYN 1213
Query: 79 --EEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRL-KSALCALRDG-------SSDK 128
+E+ E EN+ Q Q + + DG++ + C+ G ++++
Sbjct: 1214 RLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQ 1273
Query: 129 VRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEH 188
T +E+ +E LQ + K Q+ E I+A+K++ S
Sbjct: 1274 HHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKE-----IEAEKVELELKVSST 1328
Query: 189 QSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKEALDEQL 248
S S+ ++ + I + EI++ + E E+ ++ QLQ L+
Sbjct: 1329 TSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLR 1388
Query: 249 FL---VKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRNTLL 305
L + E + +S + ++ +G SE L + Q I E I+ L + +
Sbjct: 1389 ELQPKLDELQKLISKKEEDVSYLSGQLSE--KEAALTKIQTEIIEQEDLIKALHTQLEMQ 1446
Query: 306 GDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKI 365
E +E +K+++ + K E ++ ++ LQ K KEN ++E++
Sbjct: 1447 AKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEEL 1506
Query: 366 T-SHPPLKKL-KSLNDLDQ----ANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKH 419
+ + +++L KSL D++ N+E++T +L +++++ D+L + ++ + +
Sbjct: 1507 SLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEER--DKLITEMDRSLLENQS 1564
Query: 420 RRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFR 479
SS + L+ + D++ + E S+ S + + ES +E + +
Sbjct: 1565 LSSSCESLKLALEG-LTEDKEKLVKEIESLKSSK-----------IAESTEWQE---KHK 1609
Query: 480 QLTKEYQALQRAYALLQ---EQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQK 536
+L KEY+ L ++Y + E+ +++A R+ K ++L ++ +A ++ E L +
Sbjct: 1610 ELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK--QELYGKLRSTEANKKETEKQLQEA 1667
Query: 537 GQDSHWVEDK-QLFIKRNQELLEKIEKQEAENHRLQQELQDARD---------------Q 580
Q+ +++K + F K Q +KI + E EN RL+ E+ A D
Sbjct: 1668 EQEMEEMKEKMRKFAKSKQ---QKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASM 1724
Query: 581 NELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILG 640
E LE +E E ++ + S+ V L+ K N+ K
Sbjct: 1725 KEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKH----- 1779
Query: 641 DNGNLRNEEQVAII------QASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKI 694
DN EE I Q S +S + + A++A + D +I
Sbjct: 1780 DNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSA----NPAVSKDFSSHDEI 1835
Query: 695 KGYLE--EELDYRKQALDQAYMRIQELEATLYN----------------ALQQETVIKFG 736
YL+ ++L R L++ + +E TL N + QE V K
Sbjct: 1836 NNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM- 1894
Query: 737 ELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMEL---LQQAHQRIRDLEDKTDI 793
LL+++ QEEL + V KL+ + + + +++ + EL + Q + D + K ++
Sbjct: 1895 NLLNQQIQEEL-SRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNEL 1953
Query: 794 QKRQIKDLEE 803
+ ++K+L++
Sbjct: 1954 LESEMKNLKK 1963
Score = 71.2 bits (173), Expect = 4e-12
Identities = 135/631 (21%), Positives = 265/631 (41%), Gaps = 63/631 (9%)
Query: 2 SKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIREL 61
+K+ NK K E + + ANEDLR +Q E ++ L+ +Q +++ L
Sbjct: 2562 NKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTAL 2621
Query: 62 EQRKHTVLVTELKAKLHEEKMKELQAV---RENLIKQHEQEM---SRTVKVRDGEIQ-RL 114
Q + T+ + + K+ EE++ L A+ + I + E+E+ + + GEI+ +L
Sbjct: 2622 -QEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKL 2680
Query: 115 KSALCALRDGSSDKVRTALTIEAR--EEARKLFDTERLKLLQEIADLKTAKKQVD----- 167
K L L + T E R E AR L + E+ KLL + K Q+
Sbjct: 2681 KKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQ-KLLMVTKENKGLTAQIQSFGRS 2739
Query: 168 -EALSNMIQADKIKAGDLRSEHQSHQEAISKIKWES--ERDIRRLMDEIKAKDRIIFSLE 224
+L N + +L+ ++ + + ++++K + R+ L+ E FS+
Sbjct: 2740 MSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSE------TAFSMN 2793
Query: 225 KELETQTGYVQKLQLQKEALDEQLFLVK---EAECNMSSPKREIPGRAGDGSEHC----- 276
E +++KL Q + DEQL + E N + + +H
Sbjct: 2794 STEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELE 2853
Query: 277 ----SSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKC 332
S +R+ + + A ++ L+ + L ++R+ LLK ++ ++Q L+ N+
Sbjct: 2854 KFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQ---YLQINQE 2910
Query: 333 LAKRNDELMVSLQRMEEKLKAVTKENSEMR-EKITSHPPLKKLKSLNDLDQANEEQETEF 391
+ + + L LQ ++K KA E+R E ++ L +L+ +++++ E
Sbjct: 2911 ITELH-PLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLR----MEKSSWEIHERR 2965
Query: 392 LKLQVIEQQNIIDELTRDREKLIRR-RKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMA 450
+K Q + + D+ + LIR R ++P+K V E S + S
Sbjct: 2966 MKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLK--VQYQRQASPETSASPDGSQNL 3023
Query: 451 SFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAK 510
+ T+ +D L E + ELR +QL + L L Q + D + +
Sbjct: 3024 VYETELLRTQLNDSLKE---IHQKELRIQQLNSNFSQLLEEKNTLSIQ---LCDTSQSLR 3077
Query: 511 AQEQLQAEVLRYKA----KIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAE 566
+Q ++L + A ++++L+A ++K +++ E++ + +
Sbjct: 3078 ENQQHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDP--EELREPQQS 3135
Query: 567 NHRLQQELQDARDQNELLEFRNLELEERERR 597
QQ+L + R E+ E R L EER++R
Sbjct: 3136 FSEAQQQLCNTR--QEVNELRKLLEEERDQR 3164
Score = 68.6 bits (166), Expect = 2e-11
Identities = 162/800 (20%), Positives = 311/800 (38%), Gaps = 134/800 (16%)
Query: 60 ELEQRKHTVLVTELKAKLHEEKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALC 119
ELE+ K +L EL+ H+ Q + E + + +E+S ++ I+ K
Sbjct: 685 ELERLKSQIL--ELELNFHKA-----QEIYEKNLDEKAKEISNLNQL----IEEFKK--- 730
Query: 120 ALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKI 179
++D +A T + E + L + L ++ E+ + QV + N+ +A++
Sbjct: 731 -----NADNNSSAFTALSEERDQLLSQVKELSMVTEL------RAQVKQLEMNLAEAERQ 779
Query: 180 KAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELET-------QTG 232
+ D S+ +H +++ I L E K+KD I L+ EL+ Q+
Sbjct: 780 RRLDYESQ-TAHDNLLTE-------QIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQST 831
Query: 233 YVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPD--LRRNQKRIAE 290
++ LQ Q + + ++ E ++SS E+ + D L ++ +
Sbjct: 832 LIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVET 891
Query: 291 LNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEK 350
L TI + + + T + E + ++ E + ++ K E + L R EE
Sbjct: 892 LQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLK-------EQLNLLSRAEEA 944
Query: 351 LKAVTKENSEMR-------EKITSHPPLKKLKSLNDLDQANEEQETEFLKLQ--VIEQQN 401
K +E++E+ ++++ + K + ++ D +E E KLQ +I ++
Sbjct: 945 KKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKE 1004
Query: 402 IIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIG------YDEDSMDSETSSMASFRTD 455
++ ++R E+L + + P+ Y E + S+ + +
Sbjct: 1005 LLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQ 1064
Query: 456 RTPATPDD------DLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREA 509
+ DL+E LAAEE +F+ L K+ LQ++T I + E
Sbjct: 1065 TISEKEVELQHIRKDLEEKLAAEE---QFQALVKQMNQT------LQDKTNQIDLLQAEI 1115
Query: 510 KAQEQLQAEVLRYKAKIEDLEATLAQK----------GQDSHWVEDKQLFIKRNQELLEK 559
+ + +++ D ++ K G HW EL EK
Sbjct: 1116 SENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHW----------KPELEEK 1165
Query: 560 IEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYC 619
I E E +LQ++LQ+A L R L++ + + ++ D + LQ
Sbjct: 1166 ILALEKEKEQLQKKLQEA------LTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQF 1219
Query: 620 MKEGVKDVNIPDLIKQLDIL---GDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAA 676
++ ++ NI D ++QL I +G L + +Q S+ L E + E
Sbjct: 1220 DEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE--SCSSTPGLEEPLFKATE----- 1272
Query: 677 LHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIKFG 736
H LES++ C E+ + A ++ Q E A + E +K
Sbjct: 1273 QHHTQPVLESNL---CPDWPSHSEDASALQGGTSVAQIKAQLKE---IEAEKVELELKVS 1326
Query: 737 ELLSE--KQQEELRTAVEKLRRQMLR--------KSREYDCQILQERMELLQ---QAHQR 783
SE K+ EE+ E++ +Q L E + LQ+++E Q +
Sbjct: 1327 STTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEH 1386
Query: 784 IRDLEDKTDIQKRQIKDLEE 803
+R+L+ K D ++ I EE
Sbjct: 1387 LRELQPKLDELQKLISKKEE 1406
Score = 67.0 bits (162), Expect = 7e-11
Identities = 148/848 (17%), Positives = 356/848 (41%), Gaps = 136/848 (16%)
Query: 3 KKGRNKGEKPEALIVALQAANED----LRTKLTDIQIELHQEKSKVSKLEREKTQEAKRI 58
K + G+K + + + ++D L++++ ++++ H+ + K EK +E +
Sbjct: 662 KSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNL 721
Query: 59 REL--------------------------EQRKHTVLVTELKAKLHEEKMK--------- 83
+L Q K +VTEL+A++ + +M
Sbjct: 722 NQLIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRR 781
Query: 84 ---ELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREE 140
E Q +NL+ + +S K +D +I+ L++ L ++ S++ +++++ +
Sbjct: 782 LDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQ 841
Query: 141 ARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKW 200
+ ++E L+ + + + + +++ +AL S+ + + ++
Sbjct: 842 NK---ESEVLEGAERVRHISSKVEELSQAL---------------SQKELEITKMDQLLL 883
Query: 201 ESERDIRRLMDEIKAKDR----IIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAEC 256
E +RD+ L I+ KD+ I FS+ +++ L ++ + L EQL L+ AE
Sbjct: 884 EKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAE- 942
Query: 257 NMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIR-KLEDRNTLLGDERNELLKR 315
+ K ++ ++ S L++N ++ + +L+ LL E + ++
Sbjct: 943 --EAKKEQVE------EDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRK 994
Query: 316 VRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLK 375
++ K LL+R +++ +EL ++++ E E+ E K+ K
Sbjct: 995 LQAALINRKELLQR---VSRLEEELANLKDESKKEIPLSETERGEVEED-------KENK 1044
Query: 376 SLNDLDQANEEQETE-FLKLQVIEQQNIIDELTRD-REKLIRRRKHRRSSKPIKRPVLDP 433
++ ++ QE E +LK + E++ + + +D EKL + + K + + + D
Sbjct: 1045 EYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQD- 1103
Query: 434 FIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYA 493
T DL ++ +E + + +T A
Sbjct: 1104 -------------------------KTNQIDLLQAEISENQAIIQKLITSNTDASDGDSV 1138
Query: 494 LLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRN 553
L ++T ++ + + E + E+ +E + L +K Q++ + ++ +K+
Sbjct: 1139 ALVKET--VVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEA--LTSRKAILKKA 1194
Query: 554 QE----LLEKIEKQEAENHRLQQELQDARDQNELL--EFRNLELEERER---RSPPFNLQ 604
QE L E++++Q+ + +RLQ++ + +NE + + R L+++ RE + P + Q
Sbjct: 1195 QEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQ 1254
Query: 605 IHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAE 664
L+ K + P + + ++ D + + E + +Q T ++ +
Sbjct: 1255 --ESCSSTPGLEEPLFKATEQHHTQP--VLESNLCPDWPS--HSEDASALQGGTSVAQIK 1308
Query: 665 KWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLY 724
+++IE + L K+ S++ + + L+E+++ KQ L+ ++ EA ++
Sbjct: 1309 AQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQIN--KQGLEIESLKTVSHEAEVH 1366
Query: 725 -NALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSRE--YDCQILQERMELLQQAH 781
+LQQ+ ++ + EL+ +++L++ + +K + Y L E+ L +
Sbjct: 1367 AESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQ 1426
Query: 782 QRIRDLED 789
I + ED
Sbjct: 1427 TEIIEQED 1434
Score = 64.3 bits (155), Expect = 4e-10
Identities = 185/938 (19%), Positives = 353/938 (37%), Gaps = 164/938 (17%)
Query: 1 MSKKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLERE---------- 50
MS G+ E+ + L+ NE + KL I + +VS+LE E
Sbjct: 966 MSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKK 1025
Query: 51 ----------KTQEAKRIRELEQRKHTVLVTELKAKLHE---EKMKELQAVRENL---IK 94
+ +E K +E ++ T E++ L + EK ELQ +R++L +
Sbjct: 1026 EIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLA 1085
Query: 95 QHEQ------EMSRTVKVRDGEIQRLKS----------ALCALRDGSSDKVRTAL---TI 135
EQ +M++T++ + +I L++ L +SD AL T+
Sbjct: 1086 AEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETV 1145
Query: 136 EAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAI 195
+ + +L ++I L+ K+Q+ + L + + K L+ + +
Sbjct: 1146 VISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRK---AILKKAQEKERHLR 1202
Query: 196 SKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQ-KEALDEQLFLVKEA 254
++K + + D RL ++ + KE E +++LQ+Q +E++D +L +
Sbjct: 1203 EELKQQKD-DYNRLQEQFDEQ-------SKENENIGDQLRQLQIQVRESIDGKLPSTDQQ 1254
Query: 255 ECNMSSPKREIP----------------GRAGDGSEHCSSPDLRRNQKRIAELNATIRKL 298
E S+P E P D H + +A++ A ++++
Sbjct: 1255 ESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEI 1314
Query: 299 EDRNTLL----GDERNELLKRVRET---EKQCKPLLERNKCLAKRNDELMVSLQRMEEKL 351
E L +EL K+ E ++Q + L + E V + +++KL
Sbjct: 1315 EAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKL 1374
Query: 352 KAVTKENSEMREKITSHPPL--------KKLKSLNDLDQANEEQETEFLKLQ--VIEQQN 401
++ + + + P L KK + ++ L E+E K+Q +IEQ++
Sbjct: 1375 ESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQED 1434
Query: 402 IIDELTRDREKLIRRRKHR----------------------RSSKPIKRPVLDPFIGYDE 439
+I L E + R R+ + I+R + I E
Sbjct: 1435 LIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKE 1494
Query: 440 DSMDS----ETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALL 495
++ E S+A +R L +SLA ES++ + KE + ALL
Sbjct: 1495 ALKENKSLQEELSLARGTIER--------LTKSLADVESQVSAQ--NKEKDTVLGRLALL 1544
Query: 496 QEQTGGII-DAEREAKAQEQLQAEVLRYKAKIE-----------DLEATLAQK-GQDSHW 542
QE+ +I + +R + L + K +E ++E+ + K + + W
Sbjct: 1545 QEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEW 1604
Query: 543 VEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFN 602
E + K + LL+ E E R+Q ++ R + + L + L E ++
Sbjct: 1605 QEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQEL-YGKLRSTEANKKETEKQ 1663
Query: 603 LQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSL 662
LQ + ++ MKE ++ K L++ +N LR E A T
Sbjct: 1664 LQ-------EAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPA---GDTAKEC 1713
Query: 663 AEKWIQQIEGAEAALHQKMMELESDMEQFCKI---KGYLEEELDYRKQALDQAYMRIQEL 719
E + + L + ME E+ ++F + K L EE+ K ++ + L
Sbjct: 1714 METLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANL 1773
Query: 720 EAT-----LYNALQQETVIKFGEL-----LSEKQQEELRTAVEKLRRQMLRKSREYDC-Q 768
EAT N ++ T GE LS + +V + S+++
Sbjct: 1774 EATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHD 1833
Query: 769 ILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSN 806
+ ++ + Q +RI LE++ K + LE + N
Sbjct: 1834 EINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKN 1871
Score = 62.0 bits (149), Expect = 2e-09
Identities = 158/837 (18%), Positives = 342/837 (40%), Gaps = 77/837 (9%)
Query: 13 EALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR--KHTVLV 70
+A + +L E+++ + + Q + ++SK ++ T+E I +++ + + L+
Sbjct: 101 KAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELI 160
Query: 71 TELKAKLHEEK----------MKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCA 120
+ L+A+L + + M+E +++ L Q ++E T++ + + Q ++A
Sbjct: 161 STLQAQLTQAQAEQPAQSSTEMEEFVMMKQQL--QEKEEFISTLQAQLSQTQAEQAAQQV 218
Query: 121 LRDGSSDKVRTALTIEAREEARKLFDTE-RLKLLQEIADLKTAKKQVDEALSNMIQADKI 179
+R+ + + T + + E + + + ++ Q++ L+ ++ +E+L Q +
Sbjct: 219 VREKDA-RFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDL 277
Query: 180 KAGDLRSEHQSHQEAISKIK-WESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQ 238
+L + Q +Q +++ E+E + R E + ++ I + ELE +
Sbjct: 278 LQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHN 337
Query: 239 LQKEA--LDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIR 296
LQ+E L EQ +A+ + S + + E +S L QK EL +
Sbjct: 338 LQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSL-QKTGQELQSACD 396
Query: 297 KLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTK 356
L+D+N+ L ++NE + +T +Q + D+L + + + L +
Sbjct: 397 ALKDQNSKLLQDKNEQAVQSAQTIQQLE-------------DQLQQKSKEISQFLNRLPL 443
Query: 357 ENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDREKL--I 414
+ E + TS P + N+ QA E+ L+ +V+E +N L +L +
Sbjct: 444 QQHETASQ-TSFPDV-----YNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEEL 497
Query: 415 RRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEES 474
+ + SS+ + D + + +A+ R+ + D L+ + + +
Sbjct: 498 KAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHK 557
Query: 475 ELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREA---KAQEQLQAE---VLRYKAKIED 528
EL L + + A+ LQ Q +A+ E K +Q++ E ++ K +ED
Sbjct: 558 ELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLED 617
Query: 529 LE---ATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQ----N 581
+ + VE +Q + E+I +A L+ QD
Sbjct: 618 TGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDA-GVELKSTKQDGDKSLSAVP 676
Query: 582 ELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIY--CMKEGVKDV-NIPDLIKQLDI 638
++ + ELE + + L H A +IY + E K++ N+ LI++
Sbjct: 677 DIGQCHQDELERLKSQILELELNFH------KAQEIYEKNLDEKAKEISNLNQLIEEFKK 730
Query: 639 LGDNGN----LRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKI 694
DN + +EE+ ++ LS+ + Q++ E L + + D E
Sbjct: 731 NADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAH 790
Query: 695 KGYLEEELDYRKQALDQAYMRIQ----ELEATLYNALQQETVIKFGELLSEKQQEELRTA 750
L E++ ++I+ EL+ +Q T+I+ + + ++ E+
Sbjct: 791 DNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEG 850
Query: 751 VEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSNR 807
E++ R + K E + Q+ +E+ + LE K D++ Q + +EEK +
Sbjct: 851 AERV-RHISSKVEELSQALSQKELEITKMDQLL---LEKKRDVETLQ-QTIEEKDQQ 902
Score = 57.0 bits (136), Expect = 7e-08
Identities = 106/486 (21%), Positives = 204/486 (41%), Gaps = 58/486 (11%)
Query: 310 NELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHP 369
N + V+E + L+ K + ++ D V LQ+ +E L+ K +K+ H
Sbjct: 44 NTTQEDVQERLAYAEQLVVELKDIIRQKD---VQLQQKDEALQEERKAADNKIKKLKLHA 100
Query: 370 PLKKLKSLNDLDQANEEQETEFLKL--QVIEQQNIIDELTRDREKLIRRRKHRRSSKPIK 427
K L SLN + + Q L Q EQ + D+ + + E I + KH+ K
Sbjct: 101 KAK-LTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEEL 159
Query: 428 RPVLDPFIGYDEDSMDSETSS-MASFRTDRTPATPDDDLDESLAAE----ESELRFRQLT 482
L + + +++S+ M F + ++ +L A+ ++E +Q+
Sbjct: 160 ISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVV 219
Query: 483 KEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQDSHW 542
+E A L E ++ +A + ++Q ++ + K+E+ E +L + Q
Sbjct: 220 REKDARFETQVRLHEDE--LLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDL 277
Query: 543 VEDKQLFIK-RNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPF 601
++ + + RNQ L +++++ EAE++ L+ ++ R+++++L +ELE ER+
Sbjct: 278 LQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKIL-LEKMELEVAERK---- 332
Query: 602 NLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLS 661
L H + + L + G +L + L EE + S +LS
Sbjct: 333 -LSFHNLQEEMHHLLEQFEQAGQAQA---ELESRYSALEQKHKAEMEE-----KTSHILS 383
Query: 662 LAEKWIQQIEGAEAALHQKMMELESDME----QFCKIKGYLEEELDYRKQALDQAYMR-- 715
L +K Q+++ A AL + +L D Q + LE++L + + + Q R
Sbjct: 384 L-QKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLP 442
Query: 716 IQELEAT-------LYN----ALQQETVI------------KFGELLSEKQQEELRTAVE 752
+Q+ E +YN A+ +E + K LLS + EEL+ E
Sbjct: 443 LQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENE 502
Query: 753 KLRRQM 758
KL Q+
Sbjct: 503 KLSSQI 508
Score = 48.1 bits (113), Expect = 3e-05
Identities = 83/373 (22%), Positives = 164/373 (43%), Gaps = 53/373 (14%)
Query: 462 DDDLDESLAAEESELRFRQLTKEYQ--ALQRAYALLQEQTGGIIDAEREAKAQ------- 512
D+ L E A +++++ +L + + +L + ++ Q G ++ E +++ Q
Sbjct: 79 DEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKS 138
Query: 513 ---EQLQAEVLRYKAK-----IEDLEATL--AQKGQDSHWVEDKQLFIKRNQELLEKIEK 562
E+++ E +++K + I L+A L AQ Q + + + F+ Q+L EK E
Sbjct: 139 STEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEF 198
Query: 563 QEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKE 622
+L Q + Q + E ++ E + R LQ+ +D + +Q K
Sbjct: 199 ISTLQAQLSQTQAEQAAQQVVRE-KDARFETQVRLHEDELLQLVTQADVETEMQ---QKL 254
Query: 623 GVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMM 682
V + + + L +L +E A Q + +LS + +QQ+E L + +
Sbjct: 255 RVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILS---QQLQQMEAEHNTL-RNTV 310
Query: 683 ELESDMEQFCKIKGYLE------------EELDYRKQALDQAYMRIQELEATLYNALQQE 730
E E + + K LE EE+ + + +QA ELE+ Y+AL+Q+
Sbjct: 311 ETEREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESR-YSALEQK 369
Query: 731 TVIKFGELLS-----EKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIR 785
+ E S +K +EL++A + L+ Q + ++LQ++ E Q+ Q I+
Sbjct: 370 HKAEMEEKTSHILSLQKTGQELQSACDALKDQ--------NSKLLQDKNEQAVQSAQTIQ 421
Query: 786 DLEDKTDIQKRQI 798
LED+ + ++I
Sbjct: 422 QLEDQLQQKSKEI 434
Score = 42.7 bits (99), Expect = 0.001
Identities = 126/647 (19%), Positives = 266/647 (41%), Gaps = 87/647 (13%)
Query: 123 DGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNMIQADKIKAG 182
D + +R L E +E+ F+ + +QE L A++ V E L ++I+ ++
Sbjct: 20 DDTDQNMRAPLDPELHQESDMEFNNTTQEDVQE--RLAYAEQLVVE-LKDIIRQKDVQL- 75
Query: 183 DLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKE 242
Q EA+ + + ++ I++L KAK + +E++ Q G V + Q E
Sbjct: 76 ------QQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSE 129
Query: 243 ALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATIRKLEDRN 302
EQL ++ + SS + E+ E+ KL+++
Sbjct: 130 ---EQL-----SKHDKSSTEEEM------------------------EIEKIKHKLQEKE 157
Query: 303 TLLGDERNELLKRVRETEKQCKPLLER---NKCLAKRNDELMVSLQRMEEKLKAVTKENS 359
L+ + +L + E Q +E K + +E + +LQ + +A
Sbjct: 158 ELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQ 217
Query: 360 EMREK---ITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQQ-NIIDELTRDREKLIR 415
+REK + L + + L + QA+ E E + KL+V++++ +E R +++
Sbjct: 218 VVREKDARFETQVRLHEDELLQLVTQADVETEMQ-QKLRVLQRKLEEHEESLVGRAQVVD 276
Query: 416 RRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAE--E 473
+ ++ + +L + M++E +++ + T T L E + E E
Sbjct: 277 LLQQELTAAEQRNQILSQQL----QQMEAEHNTLRN--TVETEREESKILLEKMELEVAE 330
Query: 474 SELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEA-- 531
+L F L +E L + EQ G + +A+ + + A ++KA++E+ +
Sbjct: 331 RKLSFHNLQEEMHHLLEQF----EQAG-----QAQAELESRYSALEQKHKAEMEEKTSHI 381
Query: 532 -TLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQ--NELLEFRN 588
+L + GQ+ D +N +LL+ +Q ++ + Q+L+D Q E+ +F N
Sbjct: 382 LSLQKTGQELQSACD--ALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLN 439
Query: 589 -LELEERERRSPPFNLQIH------PFSDGVSALQIYCMK-EGVKDVNIPDLIKQLDILG 640
L L++ E S ++ + +++LQ ++ E K + I+ ++
Sbjct: 440 RLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKA 499
Query: 641 DNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEE 700
+N L Q+ +++A A++ + +I + A + ES + +
Sbjct: 500 ENEKL--SSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHK 557
Query: 701 ELDYRKQALDQAYMRIQELEATLYNALQQETVIKFGELLSEKQQEEL 747
EL + +A I L+ L +E E+L +K+ +++
Sbjct: 558 ELSVLLLEMKEAQEEIAFLKLQLQGKRAEEA---DHEVLDQKEMKQM 601
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 92.0 bits (227), Expect = 2e-18
Identities = 188/876 (21%), Positives = 358/876 (40%), Gaps = 132/876 (15%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQ-----EKSKVSKLEREKTQEAKR 57
++ + ++ + +V + A D + + IQ EL Q E +K + + E R
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 58 IRELEQRKHTVLVTELKAKLHEEKMKELQAVR------ENLIKQHEQEMSRTVKVRDGEI 111
+R E+ + L E + ELQA+R E +Q ++E R + E
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 112 QR-------LKSALCALRDGSSDKVRTA-----LTIEAREEARKLFDTERLKLLQEIADL 159
QR L S + A + + +K R L ++A E R+L E + Q L
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567
Query: 160 KTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRI 219
+TA++ + L + + K L Q A+++++ E+ER ++ + +A++
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Query: 220 IFSLEKELETQTGYVQKLQLQKEALDEQLFLVK-EAECNMSSPKREIPGRAGDGSEHCSS 278
LE+ + + +L+LQ E + +Q L + EAE +RE R +
Sbjct: 1628 ERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 279 PDLR----RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETE--KQCKPLLERNKC 332
+L Q+++AE A R ++ EL++ ETE +Q + LLE
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQ---------ELIRLRAETEQGEQQRQLLEEE-- 1735
Query: 333 LAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL 392
LA+ E + Q+ +E + K +EM + S +A EE +
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA------------RAEEESRSTSE 1783
Query: 393 KLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASF 452
K +Q + E R RE + R ++ KR + + E ++
Sbjct: 1784 K----SKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDAARQRA 1829
Query: 453 RTDRTPATPDDDLDESLAAE-ESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKA 511
+R A + E+ + E+E+ ++ E + L+R AE EA
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL-------------AEDEAFQ 1876
Query: 512 QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLF---IKRNQELLEKI-------E 561
+ +L+ + ++KA IE+ A L +K DS K L +++ +++ E+I E
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQL-RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 562 KQEAENHRLQQEL-------QD---ARDQNELLEFRNLEL---EERERRSPPFNLQIHPF 608
K A L+ EL +D +++Q EL R +L EER RR +Q
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 609 SDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQ 668
++ +A Q E V+ + +++ L + + Q+ + Q + A+K +Q
Sbjct: 1996 AEEEAARQRKAALEEVE--RLKAKVEEARRLRERAEQESARQLQLAQEA-----AQKRLQ 2048
Query: 669 QIEGAEA-ALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQA-YMRIQELEATLYNA 726
E A A A+ QK EL+ ++Q + L E + ++A ++A R+Q +
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2108
Query: 727 LQQETVIKFGELLSEKQQ--EELRTAVEKLRRQ--------------MLRKSREYDCQIL 770
Q E + + E+ Q + + A EKLR++ LR+ + D + +
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-M 2167
Query: 771 QERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSN 806
++ + +Q ++ +E + + Q+++ + + N
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203
Score = 86.7 bits (213), Expect = 8e-17
Identities = 130/647 (20%), Positives = 271/647 (41%), Gaps = 55/647 (8%)
Query: 22 ANEDLRTKLTDIQIELHQEKSKVSKLER--EKTQEAKRIRELEQRKHTVLVTELKAKLHE 79
A E ++ L + Q K+ + ++ER K +EA+R+RE +++ + +L + +
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ 2044
Query: 80 EKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGS--SDKVRTALTIEA 137
++++ + ++Q EQE+ +T++ + +L+ A R + +++ R EA
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 138 REEARKLFDTERLKL---------LQEIADLKTAKKQVDEALSNMIQADKI-----KAGD 183
+ R++ + ERLK Q A + +K+ ++ + QA++ +A D
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Query: 184 LRSE-HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKE 242
E H+ E + K + E+++ L +++ D L++EL+ + Q+
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 243 ALDEQLFLVK-------EAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATI 295
++E+LF V+ + + + + R + R D ++ + + K++AE A +
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK-MKQVAEEAARL 2283
Query: 296 RKLEDRNTLLGDERNELLKRVRE-TEKQCKPLLE--RNKCLAKRNDELMVSLQRM-EEKL 351
L E L + R EK K ++ + K EL+ + + +E+
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 352 KAVTKENSEMREKITSHPP-LKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDR 410
+ + ++ +M +++ ++ Q E E LKL+V E D
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 411 EKL------IRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET----SSMASFRTDRTPAT 460
++ I + HR ++ L + D + ++A ++
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Query: 461 PDDDLDESLAAEESELRFRQLTKEYQALQRAY-----ALLQEQTGGIIDAEREAKAQEQL 515
+ L + + E ++ QL +E QALQ+++ +LLQ + I+ E+ AK ++
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER--FIEQEK-AKLEQLF 2520
Query: 516 QAEVLRYKAKIEDLEATLAQKGQD-SHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQEL 574
Q EV + + E+ + Q Q+ V + +R E E + +++ E LQQ
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLE 2577
Query: 575 QDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMK 621
Q R Q ELL N L E+ + + S+ V+A Q+ K
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624
Score = 81.3 bits (199), Expect = 3e-15
Identities = 174/864 (20%), Positives = 359/864 (41%), Gaps = 116/864 (13%)
Query: 6 RNKGEKPEALIVA-LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR 64
R + E+ +A+ +A QA E LR + ++ E+ + KV + +R Q I++ E +
Sbjct: 1227 RRRQEQIQAMPLADSQAVREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQ 1285
Query: 65 KHTVLVTELKAKLHEEKMKELQAVRENLIKQ------HEQEM----SRTVKVRDGEIQRL 114
T +L+ K ++Q+ E++I++ H E+ S+ +K ++R+
Sbjct: 1286 LVTYKA-QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 115 KSA-LCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNM 173
+ A + + ++ R A A E+ R+L + Q + K ++++ E +
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 174 IQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGY 233
+A A D + + +S QE + +++ SE +I+ + +A +R +E+E+
Sbjct: 1405 EEA----AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 234 VQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRI----- 288
++ + Q+ + +L ++ + KR+ A R+ Q +
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
Query: 289 --AELNATIRKLEDRNTL--LGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSL 344
AE A K L L + E +R+R+ E + ++ A+R+ E +
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 345 QRMEEKLKAVTKENSEMREKIT----SHPPLKKLKSLNDLDQANEEQETEF--------- 391
+R K E S E + ++ + + ++A EE E E
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640
Query: 392 -----LKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET 446
L+ + + QQ + + +++K R+ RR K ++ V
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------------RQ 1686
Query: 447 SSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAE 506
+A ++ + + LAAE+ +R R T++ + ++ LL+E+ + +
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ---LLEEELARL---Q 1740
Query: 507 REAKA----QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEK 562
REA A +++L+AE+ + +A++E L A+ A+ ++S +K +R + + +
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--QRLEAEAGRFRE 1798
Query: 563 QEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKE 622
E RL+ ++A+ Q +L E E R+R ++ V A ++ + E
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAE----EDAARQRAE----------AERVLAEKLAAIGE 1844
Query: 623 GVKDVNIPDLIKQLDILGDNGNLRNE--EQVAIIQASTVLSLAEKWIQQIEGAEAALHQK 680
+ L + +I NE ++A +A L E+ Q E L Q
Sbjct: 1845 ATR------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898
Query: 681 MMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNAL--QQETVIKFGEL 738
+S++E + KG +E+ L R+Q ++ I L+A+ A + E ++ G +
Sbjct: 1899 RKASDSELE---RQKGLVEDTLRQRRQVEEE----ILALKASFEKAAAGKAELELELGRI 1951
Query: 739 -------LSEKQQEELRTAVEK-LRRQMLRKSREYDCQILQERMELLQQAHQRIRDLED- 789
L K+Q EL A ++ L + R+ RE + ++ + + A QR LE+
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 790 -----KTDIQKRQIKDLEEKSNRK 808
K + +R + E++S R+
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQ 2035
Score = 79.0 bits (193), Expect = 2e-14
Identities = 187/858 (21%), Positives = 335/858 (39%), Gaps = 177/858 (20%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR- 64
R + E L L A E R K T+ +I L +++++ +L R EA + R LE++
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 65 -KHTVLVTELKAKLHEEKMKELQAVR---ENLIKQHEQEMSRTV-------KVRDGEIQR 113
+H + E A+L + EL+ + E+ ++Q Q + K G+ +
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE- 1943
Query: 114 LKSALCALRDGSSDKVRTALTIE----------AREEARKLFDTERLKLLQEIADLKTAK 163
L+ L +R + D +R+ E A EE R+ ER++ + +A + A
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAA 2001
Query: 164 KQVDEALSNMIQADKIKAGDLRS-EHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFS 222
+Q AL ++ K K + R ++ QE+ +++ E +RL E KA +
Sbjct: 2002 RQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 223 LEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLR 282
E+EL+ Q LQ ++ LD+ L EAE RA + +E
Sbjct: 2061 KEQELQ------QTLQQEQSVLDQ---LRGEAEAAR---------RAAEEAEE------- 2095
Query: 283 RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
A + A + R + E E LK+ E + Q + + ++ E
Sbjct: 2096 ------ARVQAEREAAQSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--- 2143
Query: 343 SLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL---DQANEEQETEFLKLQVIE- 398
+E + E + +R+K + ++K K + +A EQE L+LQ+ E
Sbjct: 2144 -----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 399 --QQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDS-----MDSETSSMAS 451
Q+N++DE + + +RS ++ + + +E S +++E ++
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQ--VEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 452 FRTDRTPATPDDDLDE-----------SLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
D T ++ ++ S+AA+E+ R RQL +E A QRA A
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALA------- 2308
Query: 501 GIIDAEREAKAQEQLQAEVLRYKAKIEDLEAT--LAQKGQDSHWVEDKQLFIKRNQELLE 558
E+ K + Q E R KA+ E L+ LAQ+ Q EDK+ ++ E +
Sbjct: 2309 -----EKMLKEKMQAVQEATRLKAEAELLQQQKELAQE-QARRLQEDKEQMAQQLAEETQ 2362
Query: 559 KIEKQ-EAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQI 617
++ EAE R + +A E L+ R E+ + R+
Sbjct: 2363 GFQRTLEAERQRQLEMSAEA----ERLKLRVAEMSRAQARA------------------- 2399
Query: 618 YCMKEGVKDVNIPDLIKQLDILGDN---GNLRNEEQVAIIQASTVLSLAEKWIQQIEGAE 674
+ + KQ + +G+ L +E+V ++Q
Sbjct: 2400 --------EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT------------------ 2433
Query: 675 AALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIK 734
L + + + D E+ + LE E + +Q ++ +E++ L QET
Sbjct: 2434 --LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491
Query: 735 FGELLSEKQ---QEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKT 791
LSEK Q E EK + + L + Q L+E + QQ ++ R
Sbjct: 2492 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER------ 2545
Query: 792 DIQKRQIKDLEEKSNRKH 809
+R + +EE R+H
Sbjct: 2546 ---QRLVASMEEARRRQH 2560
Score = 76.3 bits (186), Expect = 1e-13
Identities = 166/800 (20%), Positives = 319/800 (39%), Gaps = 89/800 (11%)
Query: 44 VSKLEREKTQEAKRIRELEQRKHTVLVT---ELKAKLHEEKMKELQAVRENLIKQHEQEM 100
+ KLE+ ++ A + +L+ + T E + HEE++KE QAV L + +
Sbjct: 1071 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1130
Query: 101 SRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTER--------LKL 152
S +K + + + ALRD ++ R R + + ER L+
Sbjct: 1131 S--LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-EVERWRERVAQLLER 1187
Query: 153 LQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDE 212
Q + +++ E L ++ + A L + Q + +I+ D + + ++
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 213 IKAKDRIIFSL----EKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGR 268
++ + ++ + EK E Q Q + K+ + QL K ++SP ++ +
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQ 1306
Query: 269 AGDGSEHCSSPDLRRNQKRIAELNA--------TIRKLEDRNTLLGDERNELLKRVRETE 320
+G S DLR + + L + T+R++E+ L +R E +R+ E E
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366
Query: 321 KQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL 380
LE+ + LA+ + + +R ++L+ +E RE+ +K +L
Sbjct: 1367 ----AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422
Query: 381 DQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDED 440
Q + E E I R E R R + R L+ E
Sbjct: 1423 QQLRQSSEAE------------IQAKARQAEAAERSRLRIEEEIRVVRLQLEA----TER 1466
Query: 441 SMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
+ + R A + + A EE+E RQ+ E Q ++A L +
Sbjct: 1467 QRGGAEGELQALRARAEEA----EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522
Query: 501 GIIDAERE------AKAQEQLQAEVLRYKAKIEDLEAT--------LAQKGQDSHWVEDK 546
+A RE A + +LQAE + + ++E AQ+ ++ +
Sbjct: 1523 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1582
Query: 547 QLFIKRNQELLEKIEKQEAENHRLQQELQ-DARDQNELLEFRNLELEERERRSPPFNLQI 605
F ++ +L ++++ +L++E + A+ Q E R EE ER + L+
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR----EEAERELERWQLKA 1638
Query: 606 HPFSDGVSALQIYCMKEGV---KDVNIPDLIKQLDILGDNGNLRNE-EQVAIIQASTVLS 661
+ AL++ E V K + + KQ + R + E+ A+ Q
Sbjct: 1639 N------EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 662 LAEKWIQQIEGA---EAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQE 718
EK Q EG A Q+++ L ++ EQ + + LEEEL ++ A + QE
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQE--RMEL 776
LEA L + V+ + +E EE R+ EK ++++ ++ + ++ +E R+
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRFR-ELAEEAARLRA 1808
Query: 777 LQQAHQRIRDLEDKTDIQKR 796
L + +R R L ++ ++R
Sbjct: 1809 LAEEAKRQRQLAEEDAARQR 1828
Score = 37.7 bits (86), Expect = 0.043
Identities = 42/182 (23%), Positives = 89/182 (48%), Gaps = 16/182 (8%)
Query: 18 ALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTE---LK 74
ALQ + + L + + QEK+K+ +L +++ +A+++RE +QR+ + E L
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 75 AKLHEEKMKELQAV-----RENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKV 129
A + E + ++ +A ++ ++Q EQ+ + ++ E QRL+ L L ++
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL----EEQH 2605
Query: 130 RTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVD---EALSNMIQADKI-KAGDLR 185
R AL A ++ T+ L ++ D A+ + + + L + A ++ +AG L
Sbjct: 2606 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2665
Query: 186 SE 187
+E
Sbjct: 2666 AE 2667
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 92.0 bits (227), Expect = 2e-18
Identities = 188/876 (21%), Positives = 358/876 (40%), Gaps = 132/876 (15%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQ-----EKSKVSKLEREKTQEAKR 57
++ + ++ + +V + A D + + IQ EL Q E +K + + E R
Sbjct: 1392 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1451
Query: 58 IRELEQRKHTVLVTELKAKLHEEKMKELQAVR------ENLIKQHEQEMSRTVKVRDGEI 111
+R E+ + L E + ELQA+R E +Q ++E R + E
Sbjct: 1452 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1511
Query: 112 QR-------LKSALCALRDGSSDKVRTA-----LTIEAREEARKLFDTERLKLLQEIADL 159
QR L S + A + + +K R L ++A E R+L E + Q L
Sbjct: 1512 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1571
Query: 160 KTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRI 219
+TA++ + L + + K L Q A+++++ E+ER ++ + +A++
Sbjct: 1572 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1631
Query: 220 IFSLEKELETQTGYVQKLQLQKEALDEQLFLVK-EAECNMSSPKREIPGRAGDGSEHCSS 278
LE+ + + +L+LQ E + +Q L + EAE +RE R +
Sbjct: 1632 ERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1690
Query: 279 PDLR----RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETE--KQCKPLLERNKC 332
+L Q+++AE A R ++ EL++ ETE +Q + LLE
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQ---------ELIRLRAETEQGEQQRQLLEEE-- 1739
Query: 333 LAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL 392
LA+ E + Q+ +E + K +EM + S +A EE +
Sbjct: 1740 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA------------RAEEESRSTSE 1787
Query: 393 KLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASF 452
K +Q + E R RE + R ++ KR + + E ++
Sbjct: 1788 K----SKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDAARQRA 1833
Query: 453 RTDRTPATPDDDLDESLAAE-ESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKA 511
+R A + E+ + E+E+ ++ E + L+R AE EA
Sbjct: 1834 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL-------------AEDEAFQ 1880
Query: 512 QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLF---IKRNQELLEKI-------E 561
+ +L+ + ++KA IE+ A L +K DS K L +++ +++ E+I E
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQL-RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1939
Query: 562 KQEAENHRLQQEL-------QD---ARDQNELLEFRNLEL---EERERRSPPFNLQIHPF 608
K A L+ EL +D +++Q EL R +L EER RR +Q
Sbjct: 1940 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1999
Query: 609 SDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQ 668
++ +A Q E V+ + +++ L + + Q+ + Q + A+K +Q
Sbjct: 2000 AEEEAARQRKAALEEVE--RLKAKVEEARRLRERAEQESARQLQLAQEA-----AQKRLQ 2052
Query: 669 QIEGAEA-ALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQA-YMRIQELEATLYNA 726
E A A A+ QK EL+ ++Q + L E + ++A ++A R+Q +
Sbjct: 2053 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2112
Query: 727 LQQETVIKFGELLSEKQQ--EELRTAVEKLRRQ--------------MLRKSREYDCQIL 770
Q E + + E+ Q + + A EKLR++ LR+ + D + +
Sbjct: 2113 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-M 2171
Query: 771 QERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSN 806
++ + +Q ++ +E + + Q+++ + + N
Sbjct: 2172 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2207
Score = 86.7 bits (213), Expect = 8e-17
Identities = 130/647 (20%), Positives = 271/647 (41%), Gaps = 55/647 (8%)
Query: 22 ANEDLRTKLTDIQIELHQEKSKVSKLER--EKTQEAKRIRELEQRKHTVLVTELKAKLHE 79
A E ++ L + Q K+ + ++ER K +EA+R+RE +++ + +L + +
Sbjct: 1990 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ 2048
Query: 80 EKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGS--SDKVRTALTIEA 137
++++ + ++Q EQE+ +T++ + +L+ A R + +++ R EA
Sbjct: 2049 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2108
Query: 138 REEARKLFDTERLKL---------LQEIADLKTAKKQVDEALSNMIQADKI-----KAGD 183
+ R++ + ERLK Q A + +K+ ++ + QA++ +A D
Sbjct: 2109 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2168
Query: 184 LRSE-HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKE 242
E H+ E + K + E+++ L +++ D L++EL+ + Q+
Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2228
Query: 243 ALDEQLFLVK-------EAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATI 295
++E+LF V+ + + + + R + R D ++ + + K++AE A +
Sbjct: 2229 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK-MKQVAEEAARL 2287
Query: 296 RKLEDRNTLLGDERNELLKRVRE-TEKQCKPLLE--RNKCLAKRNDELMVSLQRM-EEKL 351
L E L + R EK K ++ + K EL+ + + +E+
Sbjct: 2288 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2347
Query: 352 KAVTKENSEMREKITSHPP-LKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDR 410
+ + ++ +M +++ ++ Q E E LKL+V E D
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2407
Query: 411 EKL------IRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET----SSMASFRTDRTPAT 460
++ I + HR ++ L + D + ++A ++
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2467
Query: 461 PDDDLDESLAAEESELRFRQLTKEYQALQRAY-----ALLQEQTGGIIDAEREAKAQEQL 515
+ L + + E ++ QL +E QALQ+++ +LLQ + I+ E+ AK ++
Sbjct: 2468 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER--FIEQEK-AKLEQLF 2524
Query: 516 QAEVLRYKAKIEDLEATLAQKGQD-SHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQEL 574
Q EV + + E+ + Q Q+ V + +R E E + +++ E LQQ
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLE 2581
Query: 575 QDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMK 621
Q R Q ELL N L E+ + + S+ V+A Q+ K
Sbjct: 2582 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2628
Score = 81.3 bits (199), Expect = 3e-15
Identities = 174/864 (20%), Positives = 359/864 (41%), Gaps = 116/864 (13%)
Query: 6 RNKGEKPEALIVA-LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR 64
R + E+ +A+ +A QA E LR + ++ E+ + KV + +R Q I++ E +
Sbjct: 1231 RRRQEQIQAMPLADSQAVREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQ 1289
Query: 65 KHTVLVTELKAKLHEEKMKELQAVRENLIKQ------HEQEM----SRTVKVRDGEIQRL 114
T +L+ K ++Q+ E++I++ H E+ S+ +K ++R+
Sbjct: 1290 LVTYKA-QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1348
Query: 115 KSA-LCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNM 173
+ A + + ++ R A A E+ R+L + Q + K ++++ E +
Sbjct: 1349 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1408
Query: 174 IQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGY 233
+A A D + + +S QE + +++ SE +I+ + +A +R +E+E+
Sbjct: 1409 EEA----AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464
Query: 234 VQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRI----- 288
++ + Q+ + +L ++ + KR+ A R+ Q +
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1524
Query: 289 --AELNATIRKLEDRNTL--LGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSL 344
AE A K L L + E +R+R+ E + ++ A+R+ E +
Sbjct: 1525 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1584
Query: 345 QRMEEKLKAVTKENSEMREKIT----SHPPLKKLKSLNDLDQANEEQETEF--------- 391
+R K E S E + ++ + + ++A EE E E
Sbjct: 1585 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1644
Query: 392 -----LKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET 446
L+ + + QQ + + +++K R+ RR K ++ V
Sbjct: 1645 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------------RQ 1690
Query: 447 SSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAE 506
+A ++ + + LAAE+ +R R T++ + ++ LL+E+ + +
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ---LLEEELARL---Q 1744
Query: 507 REAKA----QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEK 562
REA A +++L+AE+ + +A++E L A+ A+ ++S +K +R + + +
Sbjct: 1745 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--QRLEAEAGRFRE 1802
Query: 563 QEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKE 622
E RL+ ++A+ Q +L E E R+R ++ V A ++ + E
Sbjct: 1803 LAEEAARLRALAEEAKRQRQLAE----EDAARQRAE----------AERVLAEKLAAIGE 1848
Query: 623 GVKDVNIPDLIKQLDILGDNGNLRNE--EQVAIIQASTVLSLAEKWIQQIEGAEAALHQK 680
+ L + +I NE ++A +A L E+ Q E L Q
Sbjct: 1849 ATR------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1902
Query: 681 MMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNAL--QQETVIKFGEL 738
+S++E + KG +E+ L R+Q ++ I L+A+ A + E ++ G +
Sbjct: 1903 RKASDSELE---RQKGLVEDTLRQRRQVEEE----ILALKASFEKAAAGKAELELELGRI 1955
Query: 739 -------LSEKQQEELRTAVEK-LRRQMLRKSREYDCQILQERMELLQQAHQRIRDLED- 789
L K+Q EL A ++ L + R+ RE + ++ + + A QR LE+
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015
Query: 790 -----KTDIQKRQIKDLEEKSNRK 808
K + +R + E++S R+
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQ 2039
Score = 79.0 bits (193), Expect = 2e-14
Identities = 187/858 (21%), Positives = 335/858 (39%), Gaps = 177/858 (20%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR- 64
R + E L L A E R K T+ +I L +++++ +L R EA + R LE++
Sbjct: 1830 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1888
Query: 65 -KHTVLVTELKAKLHEEKMKELQAVR---ENLIKQHEQEMSRTV-------KVRDGEIQR 113
+H + E A+L + EL+ + E+ ++Q Q + K G+ +
Sbjct: 1889 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE- 1947
Query: 114 LKSALCALRDGSSDKVRTALTIE----------AREEARKLFDTERLKLLQEIADLKTAK 163
L+ L +R + D +R+ E A EE R+ ER++ + +A + A
Sbjct: 1948 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAA 2005
Query: 164 KQVDEALSNMIQADKIKAGDLRS-EHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFS 222
+Q AL ++ K K + R ++ QE+ +++ E +RL E KA +
Sbjct: 2006 RQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2064
Query: 223 LEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLR 282
E+EL+ Q LQ ++ LD+ L EAE RA + +E
Sbjct: 2065 KEQELQ------QTLQQEQSVLDQ---LRGEAEAAR---------RAAEEAEE------- 2099
Query: 283 RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
A + A + R + E E LK+ E + Q + + ++ E
Sbjct: 2100 ------ARVQAEREAAQSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--- 2147
Query: 343 SLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL---DQANEEQETEFLKLQVIE- 398
+E + E + +R+K + ++K K + +A EQE L+LQ+ E
Sbjct: 2148 -----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2202
Query: 399 --QQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDS-----MDSETSSMAS 451
Q+N++DE + + +RS ++ + + +E S +++E ++
Sbjct: 2203 DHQKNLLDEELQRLKAEATEAARQRSQ--VEEELFSVRVQMEELSKLKARIEAENRALIL 2260
Query: 452 FRTDRTPATPDDDLDE-----------SLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
D T ++ ++ S+AA+E+ R RQL +E A QRA A
Sbjct: 2261 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALA------- 2312
Query: 501 GIIDAEREAKAQEQLQAEVLRYKAKIEDLEAT--LAQKGQDSHWVEDKQLFIKRNQELLE 558
E+ K + Q E R KA+ E L+ LAQ+ Q EDK+ ++ E +
Sbjct: 2313 -----EKMLKEKMQAVQEATRLKAEAELLQQQKELAQE-QARRLQEDKEQMAQQLAEETQ 2366
Query: 559 KIEKQ-EAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQI 617
++ EAE R + +A E L+ R E+ + R+
Sbjct: 2367 GFQRTLEAERQRQLEMSAEA----ERLKLRVAEMSRAQARA------------------- 2403
Query: 618 YCMKEGVKDVNIPDLIKQLDILGDN---GNLRNEEQVAIIQASTVLSLAEKWIQQIEGAE 674
+ + KQ + +G+ L +E+V ++Q
Sbjct: 2404 --------EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT------------------ 2437
Query: 675 AALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIK 734
L + + + D E+ + LE E + +Q ++ +E++ L QET
Sbjct: 2438 --LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2495
Query: 735 FGELLSEKQ---QEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKT 791
LSEK Q E EK + + L + Q L+E + QQ ++ R
Sbjct: 2496 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER------ 2549
Query: 792 DIQKRQIKDLEEKSNRKH 809
+R + +EE R+H
Sbjct: 2550 ---QRLVASMEEARRRQH 2564
Score = 76.3 bits (186), Expect = 1e-13
Identities = 166/800 (20%), Positives = 319/800 (39%), Gaps = 89/800 (11%)
Query: 44 VSKLEREKTQEAKRIRELEQRKHTVLVT---ELKAKLHEEKMKELQAVRENLIKQHEQEM 100
+ KLE+ ++ A + +L+ + T E + HEE++KE QAV L + +
Sbjct: 1075 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1134
Query: 101 SRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTER--------LKL 152
S +K + + + ALRD ++ R R + + ER L+
Sbjct: 1135 S--LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-EVERWRERVAQLLER 1191
Query: 153 LQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDE 212
Q + +++ E L ++ + A L + Q + +I+ D + + ++
Sbjct: 1192 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1251
Query: 213 IKAKDRIIFSL----EKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGR 268
++ + ++ + EK E Q Q + K+ + QL K ++SP ++ +
Sbjct: 1252 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQ 1310
Query: 269 AGDGSEHCSSPDLRRNQKRIAELNA--------TIRKLEDRNTLLGDERNELLKRVRETE 320
+G S DLR + + L + T+R++E+ L +R E +R+ E E
Sbjct: 1311 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1370
Query: 321 KQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL 380
LE+ + LA+ + + +R ++L+ +E RE+ +K +L
Sbjct: 1371 ----AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1426
Query: 381 DQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDED 440
Q + E E I R E R R + R L+ E
Sbjct: 1427 QQLRQSSEAE------------IQAKARQAEAAERSRLRIEEEIRVVRLQLEA----TER 1470
Query: 441 SMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
+ + R A + + A EE+E RQ+ E Q ++A L +
Sbjct: 1471 QRGGAEGELQALRARAEEA----EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1526
Query: 501 GIIDAERE------AKAQEQLQAEVLRYKAKIEDLEAT--------LAQKGQDSHWVEDK 546
+A RE A + +LQAE + + ++E AQ+ ++ +
Sbjct: 1527 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1586
Query: 547 QLFIKRNQELLEKIEKQEAENHRLQQELQ-DARDQNELLEFRNLELEERERRSPPFNLQI 605
F ++ +L ++++ +L++E + A+ Q E R EE ER + L+
Sbjct: 1587 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR----EEAERELERWQLKA 1642
Query: 606 HPFSDGVSALQIYCMKEGV---KDVNIPDLIKQLDILGDNGNLRNE-EQVAIIQASTVLS 661
+ AL++ E V K + + KQ + R + E+ A+ Q
Sbjct: 1643 N------EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1696
Query: 662 LAEKWIQQIEGA---EAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQE 718
EK Q EG A Q+++ L ++ EQ + + LEEEL ++ A + QE
Sbjct: 1697 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQE--RMEL 776
LEA L + V+ + +E EE R+ EK ++++ ++ + ++ +E R+
Sbjct: 1757 LEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRFR-ELAEEAARLRA 1812
Query: 777 LQQAHQRIRDLEDKTDIQKR 796
L + +R R L ++ ++R
Sbjct: 1813 LAEEAKRQRQLAEEDAARQR 1832
Score = 37.7 bits (86), Expect = 0.043
Identities = 42/182 (23%), Positives = 89/182 (48%), Gaps = 16/182 (8%)
Query: 18 ALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTE---LK 74
ALQ + + L + + QEK+K+ +L +++ +A+++RE +QR+ + E L
Sbjct: 2494 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2553
Query: 75 AKLHEEKMKELQAV-----RENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKV 129
A + E + ++ +A ++ ++Q EQ+ + ++ E QRL+ L L ++
Sbjct: 2554 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL----EEQH 2609
Query: 130 RTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVD---EALSNMIQADKI-KAGDLR 185
R AL A ++ T+ L ++ D A+ + + + L + A ++ +AG L
Sbjct: 2610 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2669
Query: 186 SE 187
+E
Sbjct: 2670 AE 2671
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 92.0 bits (227), Expect = 2e-18
Identities = 188/876 (21%), Positives = 358/876 (40%), Gaps = 132/876 (15%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQ-----EKSKVSKLEREKTQEAKR 57
++ + ++ + +V + A D + + IQ EL Q E +K + + E R
Sbjct: 1388 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1447
Query: 58 IRELEQRKHTVLVTELKAKLHEEKMKELQAVR------ENLIKQHEQEMSRTVKVRDGEI 111
+R E+ + L E + ELQA+R E +Q ++E R + E
Sbjct: 1448 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1507
Query: 112 QR-------LKSALCALRDGSSDKVRTA-----LTIEAREEARKLFDTERLKLLQEIADL 159
QR L S + A + + +K R L ++A E R+L E + Q L
Sbjct: 1508 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1567
Query: 160 KTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRI 219
+TA++ + L + + K L Q A+++++ E+ER ++ + +A++
Sbjct: 1568 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1627
Query: 220 IFSLEKELETQTGYVQKLQLQKEALDEQLFLVK-EAECNMSSPKREIPGRAGDGSEHCSS 278
LE+ + + +L+LQ E + +Q L + EAE +RE R +
Sbjct: 1628 ERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 279 PDLR----RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETE--KQCKPLLERNKC 332
+L Q+++AE A R ++ EL++ ETE +Q + LLE
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQ---------ELIRLRAETEQGEQQRQLLEEE-- 1735
Query: 333 LAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL 392
LA+ E + Q+ +E + K +EM + S +A EE +
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA------------RAEEESRSTSE 1783
Query: 393 KLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASF 452
K +Q + E R RE + R ++ KR + + E ++
Sbjct: 1784 K----SKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDAARQRA 1829
Query: 453 RTDRTPATPDDDLDESLAAE-ESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKA 511
+R A + E+ + E+E+ ++ E + L+R AE EA
Sbjct: 1830 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL-------------AEDEAFQ 1876
Query: 512 QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLF---IKRNQELLEKI-------E 561
+ +L+ + ++KA IE+ A L +K DS K L +++ +++ E+I E
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQL-RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1935
Query: 562 KQEAENHRLQQEL-------QD---ARDQNELLEFRNLEL---EERERRSPPFNLQIHPF 608
K A L+ EL +D +++Q EL R +L EER RR +Q
Sbjct: 1936 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1995
Query: 609 SDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQ 668
++ +A Q E V+ + +++ L + + Q+ + Q + A+K +Q
Sbjct: 1996 AEEEAARQRKAALEEVE--RLKAKVEEARRLRERAEQESARQLQLAQEA-----AQKRLQ 2048
Query: 669 QIEGAEA-ALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQA-YMRIQELEATLYNA 726
E A A A+ QK EL+ ++Q + L E + ++A ++A R+Q +
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2108
Query: 727 LQQETVIKFGELLSEKQQ--EELRTAVEKLRRQ--------------MLRKSREYDCQIL 770
Q E + + E+ Q + + A EKLR++ LR+ + D + +
Sbjct: 2109 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-M 2167
Query: 771 QERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSN 806
++ + +Q ++ +E + + Q+++ + + N
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2203
Score = 86.7 bits (213), Expect = 8e-17
Identities = 130/647 (20%), Positives = 271/647 (41%), Gaps = 55/647 (8%)
Query: 22 ANEDLRTKLTDIQIELHQEKSKVSKLER--EKTQEAKRIRELEQRKHTVLVTELKAKLHE 79
A E ++ L + Q K+ + ++ER K +EA+R+RE +++ + +L + +
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ 2044
Query: 80 EKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGS--SDKVRTALTIEA 137
++++ + ++Q EQE+ +T++ + +L+ A R + +++ R EA
Sbjct: 2045 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2104
Query: 138 REEARKLFDTERLKL---------LQEIADLKTAKKQVDEALSNMIQADKI-----KAGD 183
+ R++ + ERLK Q A + +K+ ++ + QA++ +A D
Sbjct: 2105 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164
Query: 184 LRSE-HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKE 242
E H+ E + K + E+++ L +++ D L++EL+ + Q+
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2224
Query: 243 ALDEQLFLVK-------EAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATI 295
++E+LF V+ + + + + R + R D ++ + + K++AE A +
Sbjct: 2225 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK-MKQVAEEAARL 2283
Query: 296 RKLEDRNTLLGDERNELLKRVRE-TEKQCKPLLE--RNKCLAKRNDELMVSLQRM-EEKL 351
L E L + R EK K ++ + K EL+ + + +E+
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343
Query: 352 KAVTKENSEMREKITSHPP-LKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDR 410
+ + ++ +M +++ ++ Q E E LKL+V E D
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403
Query: 411 EKL------IRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET----SSMASFRTDRTPAT 460
++ I + HR ++ L + D + ++A ++
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Query: 461 PDDDLDESLAAEESELRFRQLTKEYQALQRAY-----ALLQEQTGGIIDAEREAKAQEQL 515
+ L + + E ++ QL +E QALQ+++ +LLQ + I+ E+ AK ++
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER--FIEQEK-AKLEQLF 2520
Query: 516 QAEVLRYKAKIEDLEATLAQKGQD-SHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQEL 574
Q EV + + E+ + Q Q+ V + +R E E + +++ E LQQ
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLE 2577
Query: 575 QDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMK 621
Q R Q ELL N L E+ + + S+ V+A Q+ K
Sbjct: 2578 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2624
Score = 81.3 bits (199), Expect = 3e-15
Identities = 174/864 (20%), Positives = 359/864 (41%), Gaps = 116/864 (13%)
Query: 6 RNKGEKPEALIVA-LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR 64
R + E+ +A+ +A QA E LR + ++ E+ + KV + +R Q I++ E +
Sbjct: 1227 RRRQEQIQAMPLADSQAVREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQ 1285
Query: 65 KHTVLVTELKAKLHEEKMKELQAVRENLIKQ------HEQEM----SRTVKVRDGEIQRL 114
T +L+ K ++Q+ E++I++ H E+ S+ +K ++R+
Sbjct: 1286 LVTYKA-QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 115 KSA-LCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNM 173
+ A + + ++ R A A E+ R+L + Q + K ++++ E +
Sbjct: 1345 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1404
Query: 174 IQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGY 233
+A A D + + +S QE + +++ SE +I+ + +A +R +E+E+
Sbjct: 1405 EEA----AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 234 VQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRI----- 288
++ + Q+ + +L ++ + KR+ A R+ Q +
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
Query: 289 --AELNATIRKLEDRNTL--LGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSL 344
AE A K L L + E +R+R+ E + ++ A+R+ E +
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 345 QRMEEKLKAVTKENSEMREKIT----SHPPLKKLKSLNDLDQANEEQETEF--------- 391
+R K E S E + ++ + + ++A EE E E
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1640
Query: 392 -----LKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET 446
L+ + + QQ + + +++K R+ RR K ++ V
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------------RQ 1686
Query: 447 SSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAE 506
+A ++ + + LAAE+ +R R T++ + ++ LL+E+ + +
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ---LLEEELARL---Q 1740
Query: 507 REAKA----QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEK 562
REA A +++L+AE+ + +A++E L A+ A+ ++S +K +R + + +
Sbjct: 1741 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--QRLEAEAGRFRE 1798
Query: 563 QEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKE 622
E RL+ ++A+ Q +L E E R+R ++ V A ++ + E
Sbjct: 1799 LAEEAARLRALAEEAKRQRQLAE----EDAARQRAE----------AERVLAEKLAAIGE 1844
Query: 623 GVKDVNIPDLIKQLDILGDNGNLRNE--EQVAIIQASTVLSLAEKWIQQIEGAEAALHQK 680
+ L + +I NE ++A +A L E+ Q E L Q
Sbjct: 1845 ATR------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1898
Query: 681 MMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNAL--QQETVIKFGEL 738
+S++E + KG +E+ L R+Q ++ I L+A+ A + E ++ G +
Sbjct: 1899 RKASDSELE---RQKGLVEDTLRQRRQVEEE----ILALKASFEKAAAGKAELELELGRI 1951
Query: 739 -------LSEKQQEELRTAVEK-LRRQMLRKSREYDCQILQERMELLQQAHQRIRDLED- 789
L K+Q EL A ++ L + R+ RE + ++ + + A QR LE+
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 790 -----KTDIQKRQIKDLEEKSNRK 808
K + +R + E++S R+
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQ 2035
Score = 79.0 bits (193), Expect = 2e-14
Identities = 187/858 (21%), Positives = 335/858 (39%), Gaps = 177/858 (20%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR- 64
R + E L L A E R K T+ +I L +++++ +L R EA + R LE++
Sbjct: 1826 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1884
Query: 65 -KHTVLVTELKAKLHEEKMKELQAVR---ENLIKQHEQEMSRTV-------KVRDGEIQR 113
+H + E A+L + EL+ + E+ ++Q Q + K G+ +
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE- 1943
Query: 114 LKSALCALRDGSSDKVRTALTIE----------AREEARKLFDTERLKLLQEIADLKTAK 163
L+ L +R + D +R+ E A EE R+ ER++ + +A + A
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAA 2001
Query: 164 KQVDEALSNMIQADKIKAGDLRS-EHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFS 222
+Q AL ++ K K + R ++ QE+ +++ E +RL E KA +
Sbjct: 2002 RQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 223 LEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLR 282
E+EL+ Q LQ ++ LD+ L EAE RA + +E
Sbjct: 2061 KEQELQ------QTLQQEQSVLDQ---LRGEAEAAR---------RAAEEAEE------- 2095
Query: 283 RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
A + A + R + E E LK+ E + Q + + ++ E
Sbjct: 2096 ------ARVQAEREAAQSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--- 2143
Query: 343 SLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL---DQANEEQETEFLKLQVIE- 398
+E + E + +R+K + ++K K + +A EQE L+LQ+ E
Sbjct: 2144 -----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2198
Query: 399 --QQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDS-----MDSETSSMAS 451
Q+N++DE + + +RS ++ + + +E S +++E ++
Sbjct: 2199 DHQKNLLDEELQRLKAEATEAARQRSQ--VEEELFSVRVQMEELSKLKARIEAENRALIL 2256
Query: 452 FRTDRTPATPDDDLDE-----------SLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
D T ++ ++ S+AA+E+ R RQL +E A QRA A
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALA------- 2308
Query: 501 GIIDAEREAKAQEQLQAEVLRYKAKIEDLEAT--LAQKGQDSHWVEDKQLFIKRNQELLE 558
E+ K + Q E R KA+ E L+ LAQ+ Q EDK+ ++ E +
Sbjct: 2309 -----EKMLKEKMQAVQEATRLKAEAELLQQQKELAQE-QARRLQEDKEQMAQQLAEETQ 2362
Query: 559 KIEKQ-EAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQI 617
++ EAE R + +A E L+ R E+ + R+
Sbjct: 2363 GFQRTLEAERQRQLEMSAEA----ERLKLRVAEMSRAQARA------------------- 2399
Query: 618 YCMKEGVKDVNIPDLIKQLDILGDN---GNLRNEEQVAIIQASTVLSLAEKWIQQIEGAE 674
+ + KQ + +G+ L +E+V ++Q
Sbjct: 2400 --------EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT------------------ 2433
Query: 675 AALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIK 734
L + + + D E+ + LE E + +Q ++ +E++ L QET
Sbjct: 2434 --LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2491
Query: 735 FGELLSEKQ---QEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKT 791
LSEK Q E EK + + L + Q L+E + QQ ++ R
Sbjct: 2492 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER------ 2545
Query: 792 DIQKRQIKDLEEKSNRKH 809
+R + +EE R+H
Sbjct: 2546 ---QRLVASMEEARRRQH 2560
Score = 76.3 bits (186), Expect = 1e-13
Identities = 166/800 (20%), Positives = 319/800 (39%), Gaps = 89/800 (11%)
Query: 44 VSKLEREKTQEAKRIRELEQRKHTVLVT---ELKAKLHEEKMKELQAVRENLIKQHEQEM 100
+ KLE+ ++ A + +L+ + T E + HEE++KE QAV L + +
Sbjct: 1071 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1130
Query: 101 SRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTER--------LKL 152
S +K + + + ALRD ++ R R + + ER L+
Sbjct: 1131 S--LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-EVERWRERVAQLLER 1187
Query: 153 LQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDE 212
Q + +++ E L ++ + A L + Q + +I+ D + + ++
Sbjct: 1188 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1247
Query: 213 IKAKDRIIFSL----EKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGR 268
++ + ++ + EK E Q Q + K+ + QL K ++SP ++ +
Sbjct: 1248 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQ 1306
Query: 269 AGDGSEHCSSPDLRRNQKRIAELNA--------TIRKLEDRNTLLGDERNELLKRVRETE 320
+G S DLR + + L + T+R++E+ L +R E +R+ E E
Sbjct: 1307 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1366
Query: 321 KQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL 380
LE+ + LA+ + + +R ++L+ +E RE+ +K +L
Sbjct: 1367 ----AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1422
Query: 381 DQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDED 440
Q + E E I R E R R + R L+ E
Sbjct: 1423 QQLRQSSEAE------------IQAKARQAEAAERSRLRIEEEIRVVRLQLEA----TER 1466
Query: 441 SMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
+ + R A + + A EE+E RQ+ E Q ++A L +
Sbjct: 1467 QRGGAEGELQALRARAEEA----EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1522
Query: 501 GIIDAERE------AKAQEQLQAEVLRYKAKIEDLEAT--------LAQKGQDSHWVEDK 546
+A RE A + +LQAE + + ++E AQ+ ++ +
Sbjct: 1523 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1582
Query: 547 QLFIKRNQELLEKIEKQEAENHRLQQELQ-DARDQNELLEFRNLELEERERRSPPFNLQI 605
F ++ +L ++++ +L++E + A+ Q E R EE ER + L+
Sbjct: 1583 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR----EEAERELERWQLKA 1638
Query: 606 HPFSDGVSALQIYCMKEGV---KDVNIPDLIKQLDILGDNGNLRNE-EQVAIIQASTVLS 661
+ AL++ E V K + + KQ + R + E+ A+ Q
Sbjct: 1639 N------EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1692
Query: 662 LAEKWIQQIEGA---EAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQE 718
EK Q EG A Q+++ L ++ EQ + + LEEEL ++ A + QE
Sbjct: 1693 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQE--RMEL 776
LEA L + V+ + +E EE R+ EK ++++ ++ + ++ +E R+
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRFR-ELAEEAARLRA 1808
Query: 777 LQQAHQRIRDLEDKTDIQKR 796
L + +R R L ++ ++R
Sbjct: 1809 LAEEAKRQRQLAEEDAARQR 1828
Score = 37.7 bits (86), Expect = 0.043
Identities = 42/182 (23%), Positives = 89/182 (48%), Gaps = 16/182 (8%)
Query: 18 ALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTE---LK 74
ALQ + + L + + QEK+K+ +L +++ +A+++RE +QR+ + E L
Sbjct: 2490 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2549
Query: 75 AKLHEEKMKELQAV-----RENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKV 129
A + E + ++ +A ++ ++Q EQ+ + ++ E QRL+ L L ++
Sbjct: 2550 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL----EEQH 2605
Query: 130 RTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVD---EALSNMIQADKI-KAGDLR 185
R AL A ++ T+ L ++ D A+ + + + L + A ++ +AG L
Sbjct: 2606 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2665
Query: 186 SE 187
+E
Sbjct: 2666 AE 2667
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 92.0 bits (227), Expect = 2e-18
Identities = 188/876 (21%), Positives = 358/876 (40%), Gaps = 132/876 (15%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQ-----EKSKVSKLEREKTQEAKR 57
++ + ++ + +V + A D + + IQ EL Q E +K + + E R
Sbjct: 1356 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1415
Query: 58 IRELEQRKHTVLVTELKAKLHEEKMKELQAVR------ENLIKQHEQEMSRTVKVRDGEI 111
+R E+ + L E + ELQA+R E +Q ++E R + E
Sbjct: 1416 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1475
Query: 112 QR-------LKSALCALRDGSSDKVRTA-----LTIEAREEARKLFDTERLKLLQEIADL 159
QR L S + A + + +K R L ++A E R+L E + Q L
Sbjct: 1476 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1535
Query: 160 KTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRI 219
+TA++ + L + + K L Q A+++++ E+ER ++ + +A++
Sbjct: 1536 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1595
Query: 220 IFSLEKELETQTGYVQKLQLQKEALDEQLFLVK-EAECNMSSPKREIPGRAGDGSEHCSS 278
LE+ + + +L+LQ E + +Q L + EAE +RE R +
Sbjct: 1596 ERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1654
Query: 279 PDLR----RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETE--KQCKPLLERNKC 332
+L Q+++AE A R ++ EL++ ETE +Q + LLE
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQ---------ELIRLRAETEQGEQQRQLLEEE-- 1703
Query: 333 LAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL 392
LA+ E + Q+ +E + K +EM + S +A EE +
Sbjct: 1704 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA------------RAEEESRSTSE 1751
Query: 393 KLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASF 452
K +Q + E R RE + R ++ KR + + E ++
Sbjct: 1752 K----SKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDAARQRA 1797
Query: 453 RTDRTPATPDDDLDESLAAE-ESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKA 511
+R A + E+ + E+E+ ++ E + L+R AE EA
Sbjct: 1798 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL-------------AEDEAFQ 1844
Query: 512 QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLF---IKRNQELLEKI-------E 561
+ +L+ + ++KA IE+ A L +K DS K L +++ +++ E+I E
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQL-RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1903
Query: 562 KQEAENHRLQQEL-------QD---ARDQNELLEFRNLEL---EERERRSPPFNLQIHPF 608
K A L+ EL +D +++Q EL R +L EER RR +Q
Sbjct: 1904 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1963
Query: 609 SDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQ 668
++ +A Q E V+ + +++ L + + Q+ + Q + A+K +Q
Sbjct: 1964 AEEEAARQRKAALEEVE--RLKAKVEEARRLRERAEQESARQLQLAQEA-----AQKRLQ 2016
Query: 669 QIEGAEA-ALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQA-YMRIQELEATLYNA 726
E A A A+ QK EL+ ++Q + L E + ++A ++A R+Q +
Sbjct: 2017 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2076
Query: 727 LQQETVIKFGELLSEKQQ--EELRTAVEKLRRQ--------------MLRKSREYDCQIL 770
Q E + + E+ Q + + A EKLR++ LR+ + D + +
Sbjct: 2077 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-M 2135
Query: 771 QERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSN 806
++ + +Q ++ +E + + Q+++ + + N
Sbjct: 2136 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2171
Score = 86.7 bits (213), Expect = 8e-17
Identities = 130/647 (20%), Positives = 271/647 (41%), Gaps = 55/647 (8%)
Query: 22 ANEDLRTKLTDIQIELHQEKSKVSKLER--EKTQEAKRIRELEQRKHTVLVTELKAKLHE 79
A E ++ L + Q K+ + ++ER K +EA+R+RE +++ + +L + +
Sbjct: 1954 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ 2012
Query: 80 EKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGS--SDKVRTALTIEA 137
++++ + ++Q EQE+ +T++ + +L+ A R + +++ R EA
Sbjct: 2013 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2072
Query: 138 REEARKLFDTERLKL---------LQEIADLKTAKKQVDEALSNMIQADKI-----KAGD 183
+ R++ + ERLK Q A + +K+ ++ + QA++ +A D
Sbjct: 2073 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2132
Query: 184 LRSE-HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKE 242
E H+ E + K + E+++ L +++ D L++EL+ + Q+
Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2192
Query: 243 ALDEQLFLVK-------EAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATI 295
++E+LF V+ + + + + R + R D ++ + + K++AE A +
Sbjct: 2193 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK-MKQVAEEAARL 2251
Query: 296 RKLEDRNTLLGDERNELLKRVRE-TEKQCKPLLE--RNKCLAKRNDELMVSLQRM-EEKL 351
L E L + R EK K ++ + K EL+ + + +E+
Sbjct: 2252 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2311
Query: 352 KAVTKENSEMREKITSHPP-LKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDR 410
+ + ++ +M +++ ++ Q E E LKL+V E D
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2371
Query: 411 EKL------IRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET----SSMASFRTDRTPAT 460
++ I + HR ++ L + D + ++A ++
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2431
Query: 461 PDDDLDESLAAEESELRFRQLTKEYQALQRAY-----ALLQEQTGGIIDAEREAKAQEQL 515
+ L + + E ++ QL +E QALQ+++ +LLQ + I+ E+ AK ++
Sbjct: 2432 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER--FIEQEK-AKLEQLF 2488
Query: 516 QAEVLRYKAKIEDLEATLAQKGQD-SHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQEL 574
Q EV + + E+ + Q Q+ V + +R E E + +++ E LQQ
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLE 2545
Query: 575 QDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMK 621
Q R Q ELL N L E+ + + S+ V+A Q+ K
Sbjct: 2546 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2592
Score = 81.3 bits (199), Expect = 3e-15
Identities = 174/864 (20%), Positives = 359/864 (41%), Gaps = 116/864 (13%)
Query: 6 RNKGEKPEALIVA-LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR 64
R + E+ +A+ +A QA E LR + ++ E+ + KV + +R Q I++ E +
Sbjct: 1195 RRRQEQIQAMPLADSQAVREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQ 1253
Query: 65 KHTVLVTELKAKLHEEKMKELQAVRENLIKQ------HEQEM----SRTVKVRDGEIQRL 114
T +L+ K ++Q+ E++I++ H E+ S+ +K ++R+
Sbjct: 1254 LVTYKA-QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1312
Query: 115 KSA-LCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNM 173
+ A + + ++ R A A E+ R+L + Q + K ++++ E +
Sbjct: 1313 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1372
Query: 174 IQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGY 233
+A A D + + +S QE + +++ SE +I+ + +A +R +E+E+
Sbjct: 1373 EEA----AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428
Query: 234 VQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRI----- 288
++ + Q+ + +L ++ + KR+ A R+ Q +
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1488
Query: 289 --AELNATIRKLEDRNTL--LGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSL 344
AE A K L L + E +R+R+ E + ++ A+R+ E +
Sbjct: 1489 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1548
Query: 345 QRMEEKLKAVTKENSEMREKIT----SHPPLKKLKSLNDLDQANEEQETEF--------- 391
+R K E S E + ++ + + ++A EE E E
Sbjct: 1549 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1608
Query: 392 -----LKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET 446
L+ + + QQ + + +++K R+ RR K ++ V
Sbjct: 1609 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------------RQ 1654
Query: 447 SSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAE 506
+A ++ + + LAAE+ +R R T++ + ++ LL+E+ + +
Sbjct: 1655 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ---LLEEELARL---Q 1708
Query: 507 REAKA----QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEK 562
REA A +++L+AE+ + +A++E L A+ A+ ++S +K +R + + +
Sbjct: 1709 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--QRLEAEAGRFRE 1766
Query: 563 QEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKE 622
E RL+ ++A+ Q +L E E R+R ++ V A ++ + E
Sbjct: 1767 LAEEAARLRALAEEAKRQRQLAE----EDAARQRAE----------AERVLAEKLAAIGE 1812
Query: 623 GVKDVNIPDLIKQLDILGDNGNLRNE--EQVAIIQASTVLSLAEKWIQQIEGAEAALHQK 680
+ L + +I NE ++A +A L E+ Q E L Q
Sbjct: 1813 ATR------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1866
Query: 681 MMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNAL--QQETVIKFGEL 738
+S++E + KG +E+ L R+Q ++ I L+A+ A + E ++ G +
Sbjct: 1867 RKASDSELE---RQKGLVEDTLRQRRQVEEE----ILALKASFEKAAAGKAELELELGRI 1919
Query: 739 -------LSEKQQEELRTAVEK-LRRQMLRKSREYDCQILQERMELLQQAHQRIRDLED- 789
L K+Q EL A ++ L + R+ RE + ++ + + A QR LE+
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979
Query: 790 -----KTDIQKRQIKDLEEKSNRK 808
K + +R + E++S R+
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQ 2003
Score = 79.0 bits (193), Expect = 2e-14
Identities = 187/858 (21%), Positives = 335/858 (39%), Gaps = 177/858 (20%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR- 64
R + E L L A E R K T+ +I L +++++ +L R EA + R LE++
Sbjct: 1794 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1852
Query: 65 -KHTVLVTELKAKLHEEKMKELQAVR---ENLIKQHEQEMSRTV-------KVRDGEIQR 113
+H + E A+L + EL+ + E+ ++Q Q + K G+ +
Sbjct: 1853 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE- 1911
Query: 114 LKSALCALRDGSSDKVRTALTIE----------AREEARKLFDTERLKLLQEIADLKTAK 163
L+ L +R + D +R+ E A EE R+ ER++ + +A + A
Sbjct: 1912 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAA 1969
Query: 164 KQVDEALSNMIQADKIKAGDLRS-EHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFS 222
+Q AL ++ K K + R ++ QE+ +++ E +RL E KA +
Sbjct: 1970 RQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2028
Query: 223 LEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLR 282
E+EL+ Q LQ ++ LD+ L EAE RA + +E
Sbjct: 2029 KEQELQ------QTLQQEQSVLDQ---LRGEAEAAR---------RAAEEAEE------- 2063
Query: 283 RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
A + A + R + E E LK+ E + Q + + ++ E
Sbjct: 2064 ------ARVQAEREAAQSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--- 2111
Query: 343 SLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL---DQANEEQETEFLKLQVIE- 398
+E + E + +R+K + ++K K + +A EQE L+LQ+ E
Sbjct: 2112 -----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2166
Query: 399 --QQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDS-----MDSETSSMAS 451
Q+N++DE + + +RS ++ + + +E S +++E ++
Sbjct: 2167 DHQKNLLDEELQRLKAEATEAARQRSQ--VEEELFSVRVQMEELSKLKARIEAENRALIL 2224
Query: 452 FRTDRTPATPDDDLDE-----------SLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
D T ++ ++ S+AA+E+ R RQL +E A QRA A
Sbjct: 2225 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALA------- 2276
Query: 501 GIIDAEREAKAQEQLQAEVLRYKAKIEDLEAT--LAQKGQDSHWVEDKQLFIKRNQELLE 558
E+ K + Q E R KA+ E L+ LAQ+ Q EDK+ ++ E +
Sbjct: 2277 -----EKMLKEKMQAVQEATRLKAEAELLQQQKELAQE-QARRLQEDKEQMAQQLAEETQ 2330
Query: 559 KIEKQ-EAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQI 617
++ EAE R + +A E L+ R E+ + R+
Sbjct: 2331 GFQRTLEAERQRQLEMSAEA----ERLKLRVAEMSRAQARA------------------- 2367
Query: 618 YCMKEGVKDVNIPDLIKQLDILGDN---GNLRNEEQVAIIQASTVLSLAEKWIQQIEGAE 674
+ + KQ + +G+ L +E+V ++Q
Sbjct: 2368 --------EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT------------------ 2401
Query: 675 AALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIK 734
L + + + D E+ + LE E + +Q ++ +E++ L QET
Sbjct: 2402 --LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2459
Query: 735 FGELLSEKQ---QEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKT 791
LSEK Q E EK + + L + Q L+E + QQ ++ R
Sbjct: 2460 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER------ 2513
Query: 792 DIQKRQIKDLEEKSNRKH 809
+R + +EE R+H
Sbjct: 2514 ---QRLVASMEEARRRQH 2528
Score = 76.3 bits (186), Expect = 1e-13
Identities = 166/800 (20%), Positives = 319/800 (39%), Gaps = 89/800 (11%)
Query: 44 VSKLEREKTQEAKRIRELEQRKHTVLVT---ELKAKLHEEKMKELQAVRENLIKQHEQEM 100
+ KLE+ ++ A + +L+ + T E + HEE++KE QAV L + +
Sbjct: 1039 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1098
Query: 101 SRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTER--------LKL 152
S +K + + + ALRD ++ R R + + ER L+
Sbjct: 1099 S--LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-EVERWRERVAQLLER 1155
Query: 153 LQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDE 212
Q + +++ E L ++ + A L + Q + +I+ D + + ++
Sbjct: 1156 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1215
Query: 213 IKAKDRIIFSL----EKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGR 268
++ + ++ + EK E Q Q + K+ + QL K ++SP ++ +
Sbjct: 1216 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQ 1274
Query: 269 AGDGSEHCSSPDLRRNQKRIAELNA--------TIRKLEDRNTLLGDERNELLKRVRETE 320
+G S DLR + + L + T+R++E+ L +R E +R+ E E
Sbjct: 1275 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1334
Query: 321 KQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL 380
LE+ + LA+ + + +R ++L+ +E RE+ +K +L
Sbjct: 1335 ----AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1390
Query: 381 DQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDED 440
Q + E E I R E R R + R L+ E
Sbjct: 1391 QQLRQSSEAE------------IQAKARQAEAAERSRLRIEEEIRVVRLQLEA----TER 1434
Query: 441 SMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
+ + R A + + A EE+E RQ+ E Q ++A L +
Sbjct: 1435 QRGGAEGELQALRARAEEA----EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1490
Query: 501 GIIDAERE------AKAQEQLQAEVLRYKAKIEDLEAT--------LAQKGQDSHWVEDK 546
+A RE A + +LQAE + + ++E AQ+ ++ +
Sbjct: 1491 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1550
Query: 547 QLFIKRNQELLEKIEKQEAENHRLQQELQ-DARDQNELLEFRNLELEERERRSPPFNLQI 605
F ++ +L ++++ +L++E + A+ Q E R EE ER + L+
Sbjct: 1551 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR----EEAERELERWQLKA 1606
Query: 606 HPFSDGVSALQIYCMKEGV---KDVNIPDLIKQLDILGDNGNLRNE-EQVAIIQASTVLS 661
+ AL++ E V K + + KQ + R + E+ A+ Q
Sbjct: 1607 N------EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1660
Query: 662 LAEKWIQQIEGA---EAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQE 718
EK Q EG A Q+++ L ++ EQ + + LEEEL ++ A + QE
Sbjct: 1661 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQE--RMEL 776
LEA L + V+ + +E EE R+ EK ++++ ++ + ++ +E R+
Sbjct: 1721 LEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRFR-ELAEEAARLRA 1776
Query: 777 LQQAHQRIRDLEDKTDIQKR 796
L + +R R L ++ ++R
Sbjct: 1777 LAEEAKRQRQLAEEDAARQR 1796
Score = 37.7 bits (86), Expect = 0.043
Identities = 42/182 (23%), Positives = 89/182 (48%), Gaps = 16/182 (8%)
Query: 18 ALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTE---LK 74
ALQ + + L + + QEK+K+ +L +++ +A+++RE +QR+ + E L
Sbjct: 2458 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2517
Query: 75 AKLHEEKMKELQAV-----RENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKV 129
A + E + ++ +A ++ ++Q EQ+ + ++ E QRL+ L L ++
Sbjct: 2518 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL----EEQH 2573
Query: 130 RTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVD---EALSNMIQADKI-KAGDLR 185
R AL A ++ T+ L ++ D A+ + + + L + A ++ +AG L
Sbjct: 2574 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2633
Query: 186 SE 187
+E
Sbjct: 2634 AE 2635
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 92.0 bits (227), Expect = 2e-18
Identities = 188/876 (21%), Positives = 358/876 (40%), Gaps = 132/876 (15%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQ-----EKSKVSKLEREKTQEAKR 57
++ + ++ + +V + A D + + IQ EL Q E +K + + E R
Sbjct: 1525 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1584
Query: 58 IRELEQRKHTVLVTELKAKLHEEKMKELQAVR------ENLIKQHEQEMSRTVKVRDGEI 111
+R E+ + L E + ELQA+R E +Q ++E R + E
Sbjct: 1585 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1644
Query: 112 QR-------LKSALCALRDGSSDKVRTA-----LTIEAREEARKLFDTERLKLLQEIADL 159
QR L S + A + + +K R L ++A E R+L E + Q L
Sbjct: 1645 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1704
Query: 160 KTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRI 219
+TA++ + L + + K L Q A+++++ E+ER ++ + +A++
Sbjct: 1705 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1764
Query: 220 IFSLEKELETQTGYVQKLQLQKEALDEQLFLVK-EAECNMSSPKREIPGRAGDGSEHCSS 278
LE+ + + +L+LQ E + +Q L + EAE +RE R +
Sbjct: 1765 ERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1823
Query: 279 PDLR----RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETE--KQCKPLLERNKC 332
+L Q+++AE A R ++ EL++ ETE +Q + LLE
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQ---------ELIRLRAETEQGEQQRQLLEEE-- 1872
Query: 333 LAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL 392
LA+ E + Q+ +E + K +EM + S +A EE +
Sbjct: 1873 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA------------RAEEESRSTSE 1920
Query: 393 KLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASF 452
K +Q + E R RE + R ++ KR + + E ++
Sbjct: 1921 K----SKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDAARQRA 1966
Query: 453 RTDRTPATPDDDLDESLAAE-ESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKA 511
+R A + E+ + E+E+ ++ E + L+R AE EA
Sbjct: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL-------------AEDEAFQ 2013
Query: 512 QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLF---IKRNQELLEKI-------E 561
+ +L+ + ++KA IE+ A L +K DS K L +++ +++ E+I E
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQL-RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 2072
Query: 562 KQEAENHRLQQEL-------QD---ARDQNELLEFRNLEL---EERERRSPPFNLQIHPF 608
K A L+ EL +D +++Q EL R +L EER RR +Q
Sbjct: 2073 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2132
Query: 609 SDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQ 668
++ +A Q E V+ + +++ L + + Q+ + Q + A+K +Q
Sbjct: 2133 AEEEAARQRKAALEEVE--RLKAKVEEARRLRERAEQESARQLQLAQEA-----AQKRLQ 2185
Query: 669 QIEGAEA-ALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQA-YMRIQELEATLYNA 726
E A A A+ QK EL+ ++Q + L E + ++A ++A R+Q +
Sbjct: 2186 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2245
Query: 727 LQQETVIKFGELLSEKQQ--EELRTAVEKLRRQ--------------MLRKSREYDCQIL 770
Q E + + E+ Q + + A EKLR++ LR+ + D + +
Sbjct: 2246 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-M 2304
Query: 771 QERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSN 806
++ + +Q ++ +E + + Q+++ + + N
Sbjct: 2305 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2340
Score = 86.7 bits (213), Expect = 8e-17
Identities = 130/647 (20%), Positives = 271/647 (41%), Gaps = 55/647 (8%)
Query: 22 ANEDLRTKLTDIQIELHQEKSKVSKLER--EKTQEAKRIRELEQRKHTVLVTELKAKLHE 79
A E ++ L + Q K+ + ++ER K +EA+R+RE +++ + +L + +
Sbjct: 2123 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ 2181
Query: 80 EKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGS--SDKVRTALTIEA 137
++++ + ++Q EQE+ +T++ + +L+ A R + +++ R EA
Sbjct: 2182 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2241
Query: 138 REEARKLFDTERLKL---------LQEIADLKTAKKQVDEALSNMIQADKI-----KAGD 183
+ R++ + ERLK Q A + +K+ ++ + QA++ +A D
Sbjct: 2242 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301
Query: 184 LRSE-HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKE 242
E H+ E + K + E+++ L +++ D L++EL+ + Q+
Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361
Query: 243 ALDEQLFLVK-------EAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATI 295
++E+LF V+ + + + + R + R D ++ + + K++AE A +
Sbjct: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK-MKQVAEEAARL 2420
Query: 296 RKLEDRNTLLGDERNELLKRVRE-TEKQCKPLLE--RNKCLAKRNDELMVSLQRM-EEKL 351
L E L + R EK K ++ + K EL+ + + +E+
Sbjct: 2421 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2480
Query: 352 KAVTKENSEMREKITSHPP-LKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDR 410
+ + ++ +M +++ ++ Q E E LKL+V E D
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2540
Query: 411 EKL------IRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET----SSMASFRTDRTPAT 460
++ I + HR ++ L + D + ++A ++
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2600
Query: 461 PDDDLDESLAAEESELRFRQLTKEYQALQRAY-----ALLQEQTGGIIDAEREAKAQEQL 515
+ L + + E ++ QL +E QALQ+++ +LLQ + I+ E+ AK ++
Sbjct: 2601 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER--FIEQEK-AKLEQLF 2657
Query: 516 QAEVLRYKAKIEDLEATLAQKGQD-SHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQEL 574
Q EV + + E+ + Q Q+ V + +R E E + +++ E LQQ
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLE 2714
Query: 575 QDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMK 621
Q R Q ELL N L E+ + + S+ V+A Q+ K
Sbjct: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2761
Score = 81.3 bits (199), Expect = 3e-15
Identities = 174/864 (20%), Positives = 359/864 (41%), Gaps = 116/864 (13%)
Query: 6 RNKGEKPEALIVA-LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR 64
R + E+ +A+ +A QA E LR + ++ E+ + KV + +R Q I++ E +
Sbjct: 1364 RRRQEQIQAMPLADSQAVREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQ 1422
Query: 65 KHTVLVTELKAKLHEEKMKELQAVRENLIKQ------HEQEM----SRTVKVRDGEIQRL 114
T +L+ K ++Q+ E++I++ H E+ S+ +K ++R+
Sbjct: 1423 LVTYKA-QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1481
Query: 115 KSA-LCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNM 173
+ A + + ++ R A A E+ R+L + Q + K ++++ E +
Sbjct: 1482 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1541
Query: 174 IQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGY 233
+A A D + + +S QE + +++ SE +I+ + +A +R +E+E+
Sbjct: 1542 EEA----AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597
Query: 234 VQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRI----- 288
++ + Q+ + +L ++ + KR+ A R+ Q +
Sbjct: 1598 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1657
Query: 289 --AELNATIRKLEDRNTL--LGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSL 344
AE A K L L + E +R+R+ E + ++ A+R+ E +
Sbjct: 1658 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1717
Query: 345 QRMEEKLKAVTKENSEMREKIT----SHPPLKKLKSLNDLDQANEEQETEF--------- 391
+R K E S E + ++ + + ++A EE E E
Sbjct: 1718 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1777
Query: 392 -----LKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET 446
L+ + + QQ + + +++K R+ RR K ++ V
Sbjct: 1778 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------------RQ 1823
Query: 447 SSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAE 506
+A ++ + + LAAE+ +R R T++ + ++ LL+E+ + +
Sbjct: 1824 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ---LLEEELARL---Q 1877
Query: 507 REAKA----QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEK 562
REA A +++L+AE+ + +A++E L A+ A+ ++S +K +R + + +
Sbjct: 1878 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--QRLEAEAGRFRE 1935
Query: 563 QEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKE 622
E RL+ ++A+ Q +L E E R+R ++ V A ++ + E
Sbjct: 1936 LAEEAARLRALAEEAKRQRQLAE----EDAARQRAE----------AERVLAEKLAAIGE 1981
Query: 623 GVKDVNIPDLIKQLDILGDNGNLRNE--EQVAIIQASTVLSLAEKWIQQIEGAEAALHQK 680
+ L + +I NE ++A +A L E+ Q E L Q
Sbjct: 1982 ATR------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 2035
Query: 681 MMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNAL--QQETVIKFGEL 738
+S++E + KG +E+ L R+Q ++ I L+A+ A + E ++ G +
Sbjct: 2036 RKASDSELE---RQKGLVEDTLRQRRQVEEE----ILALKASFEKAAAGKAELELELGRI 2088
Query: 739 -------LSEKQQEELRTAVEK-LRRQMLRKSREYDCQILQERMELLQQAHQRIRDLED- 789
L K+Q EL A ++ L + R+ RE + ++ + + A QR LE+
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148
Query: 790 -----KTDIQKRQIKDLEEKSNRK 808
K + +R + E++S R+
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQ 2172
Score = 79.0 bits (193), Expect = 2e-14
Identities = 187/858 (21%), Positives = 335/858 (39%), Gaps = 177/858 (20%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR- 64
R + E L L A E R K T+ +I L +++++ +L R EA + R LE++
Sbjct: 1963 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 2021
Query: 65 -KHTVLVTELKAKLHEEKMKELQAVR---ENLIKQHEQEMSRTV-------KVRDGEIQR 113
+H + E A+L + EL+ + E+ ++Q Q + K G+ +
Sbjct: 2022 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE- 2080
Query: 114 LKSALCALRDGSSDKVRTALTIE----------AREEARKLFDTERLKLLQEIADLKTAK 163
L+ L +R + D +R+ E A EE R+ ER++ + +A + A
Sbjct: 2081 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAA 2138
Query: 164 KQVDEALSNMIQADKIKAGDLRS-EHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFS 222
+Q AL ++ K K + R ++ QE+ +++ E +RL E KA +
Sbjct: 2139 RQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2197
Query: 223 LEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLR 282
E+EL+ Q LQ ++ LD+ L EAE RA + +E
Sbjct: 2198 KEQELQ------QTLQQEQSVLDQ---LRGEAEAAR---------RAAEEAEE------- 2232
Query: 283 RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
A + A + R + E E LK+ E + Q + + ++ E
Sbjct: 2233 ------ARVQAEREAAQSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--- 2280
Query: 343 SLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL---DQANEEQETEFLKLQVIE- 398
+E + E + +R+K + ++K K + +A EQE L+LQ+ E
Sbjct: 2281 -----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335
Query: 399 --QQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDS-----MDSETSSMAS 451
Q+N++DE + + +RS ++ + + +E S +++E ++
Sbjct: 2336 DHQKNLLDEELQRLKAEATEAARQRSQ--VEEELFSVRVQMEELSKLKARIEAENRALIL 2393
Query: 452 FRTDRTPATPDDDLDE-----------SLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
D T ++ ++ S+AA+E+ R RQL +E A QRA A
Sbjct: 2394 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALA------- 2445
Query: 501 GIIDAEREAKAQEQLQAEVLRYKAKIEDLEAT--LAQKGQDSHWVEDKQLFIKRNQELLE 558
E+ K + Q E R KA+ E L+ LAQ+ Q EDK+ ++ E +
Sbjct: 2446 -----EKMLKEKMQAVQEATRLKAEAELLQQQKELAQE-QARRLQEDKEQMAQQLAEETQ 2499
Query: 559 KIEKQ-EAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQI 617
++ EAE R + +A E L+ R E+ + R+
Sbjct: 2500 GFQRTLEAERQRQLEMSAEA----ERLKLRVAEMSRAQARA------------------- 2536
Query: 618 YCMKEGVKDVNIPDLIKQLDILGDN---GNLRNEEQVAIIQASTVLSLAEKWIQQIEGAE 674
+ + KQ + +G+ L +E+V ++Q
Sbjct: 2537 --------EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT------------------ 2570
Query: 675 AALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIK 734
L + + + D E+ + LE E + +Q ++ +E++ L QET
Sbjct: 2571 --LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2628
Query: 735 FGELLSEKQ---QEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKT 791
LSEK Q E EK + + L + Q L+E + QQ ++ R
Sbjct: 2629 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER------ 2682
Query: 792 DIQKRQIKDLEEKSNRKH 809
+R + +EE R+H
Sbjct: 2683 ---QRLVASMEEARRRQH 2697
Score = 76.3 bits (186), Expect = 1e-13
Identities = 166/800 (20%), Positives = 319/800 (39%), Gaps = 89/800 (11%)
Query: 44 VSKLEREKTQEAKRIRELEQRKHTVLVT---ELKAKLHEEKMKELQAVRENLIKQHEQEM 100
+ KLE+ ++ A + +L+ + T E + HEE++KE QAV L + +
Sbjct: 1208 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1267
Query: 101 SRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTER--------LKL 152
S +K + + + ALRD ++ R R + + ER L+
Sbjct: 1268 S--LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-EVERWRERVAQLLER 1324
Query: 153 LQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDE 212
Q + +++ E L ++ + A L + Q + +I+ D + + ++
Sbjct: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384
Query: 213 IKAKDRIIFSL----EKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGR 268
++ + ++ + EK E Q Q + K+ + QL K ++SP ++ +
Sbjct: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQ 1443
Query: 269 AGDGSEHCSSPDLRRNQKRIAELNA--------TIRKLEDRNTLLGDERNELLKRVRETE 320
+G S DLR + + L + T+R++E+ L +R E +R+ E E
Sbjct: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503
Query: 321 KQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL 380
LE+ + LA+ + + +R ++L+ +E RE+ +K +L
Sbjct: 1504 ----AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1559
Query: 381 DQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDED 440
Q + E E I R E R R + R L+ E
Sbjct: 1560 QQLRQSSEAE------------IQAKARQAEAAERSRLRIEEEIRVVRLQLEA----TER 1603
Query: 441 SMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
+ + R A + + A EE+E RQ+ E Q ++A L +
Sbjct: 1604 QRGGAEGELQALRARAEEA----EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1659
Query: 501 GIIDAERE------AKAQEQLQAEVLRYKAKIEDLEAT--------LAQKGQDSHWVEDK 546
+A RE A + +LQAE + + ++E AQ+ ++ +
Sbjct: 1660 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1719
Query: 547 QLFIKRNQELLEKIEKQEAENHRLQQELQ-DARDQNELLEFRNLELEERERRSPPFNLQI 605
F ++ +L ++++ +L++E + A+ Q E R EE ER + L+
Sbjct: 1720 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR----EEAERELERWQLKA 1775
Query: 606 HPFSDGVSALQIYCMKEGV---KDVNIPDLIKQLDILGDNGNLRNE-EQVAIIQASTVLS 661
+ AL++ E V K + + KQ + R + E+ A+ Q
Sbjct: 1776 N------EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1829
Query: 662 LAEKWIQQIEGA---EAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQE 718
EK Q EG A Q+++ L ++ EQ + + LEEEL ++ A + QE
Sbjct: 1830 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQE--RMEL 776
LEA L + V+ + +E EE R+ EK ++++ ++ + ++ +E R+
Sbjct: 1890 LEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRFR-ELAEEAARLRA 1945
Query: 777 LQQAHQRIRDLEDKTDIQKR 796
L + +R R L ++ ++R
Sbjct: 1946 LAEEAKRQRQLAEEDAARQR 1965
Score = 37.7 bits (86), Expect = 0.043
Identities = 42/182 (23%), Positives = 89/182 (48%), Gaps = 16/182 (8%)
Query: 18 ALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTE---LK 74
ALQ + + L + + QEK+K+ +L +++ +A+++RE +QR+ + E L
Sbjct: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686
Query: 75 AKLHEEKMKELQAV-----RENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKV 129
A + E + ++ +A ++ ++Q EQ+ + ++ E QRL+ L L ++
Sbjct: 2687 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL----EEQH 2742
Query: 130 RTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVD---EALSNMIQADKI-KAGDLR 185
R AL A ++ T+ L ++ D A+ + + + L + A ++ +AG L
Sbjct: 2743 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2802
Query: 186 SE 187
+E
Sbjct: 2803 AE 2804
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 92.0 bits (227), Expect = 2e-18
Identities = 188/876 (21%), Positives = 358/876 (40%), Gaps = 132/876 (15%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQ-----EKSKVSKLEREKTQEAKR 57
++ + ++ + +V + A D + + IQ EL Q E +K + + E R
Sbjct: 1366 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1425
Query: 58 IRELEQRKHTVLVTELKAKLHEEKMKELQAVR------ENLIKQHEQEMSRTVKVRDGEI 111
+R E+ + L E + ELQA+R E +Q ++E R + E
Sbjct: 1426 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1485
Query: 112 QR-------LKSALCALRDGSSDKVRTA-----LTIEAREEARKLFDTERLKLLQEIADL 159
QR L S + A + + +K R L ++A E R+L E + Q L
Sbjct: 1486 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1545
Query: 160 KTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRI 219
+TA++ + L + + K L Q A+++++ E+ER ++ + +A++
Sbjct: 1546 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1605
Query: 220 IFSLEKELETQTGYVQKLQLQKEALDEQLFLVK-EAECNMSSPKREIPGRAGDGSEHCSS 278
LE+ + + +L+LQ E + +Q L + EAE +RE R +
Sbjct: 1606 ERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1664
Query: 279 PDLR----RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETE--KQCKPLLERNKC 332
+L Q+++AE A R ++ EL++ ETE +Q + LLE
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQ---------ELIRLRAETEQGEQQRQLLEEE-- 1713
Query: 333 LAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL 392
LA+ E + Q+ +E + K +EM + S +A EE +
Sbjct: 1714 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA------------RAEEESRSTSE 1761
Query: 393 KLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASF 452
K +Q + E R RE + R ++ KR + + E ++
Sbjct: 1762 K----SKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDAARQRA 1807
Query: 453 RTDRTPATPDDDLDESLAAE-ESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKA 511
+R A + E+ + E+E+ ++ E + L+R AE EA
Sbjct: 1808 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL-------------AEDEAFQ 1854
Query: 512 QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLF---IKRNQELLEKI-------E 561
+ +L+ + ++KA IE+ A L +K DS K L +++ +++ E+I E
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQL-RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1913
Query: 562 KQEAENHRLQQEL-------QD---ARDQNELLEFRNLEL---EERERRSPPFNLQIHPF 608
K A L+ EL +D +++Q EL R +L EER RR +Q
Sbjct: 1914 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1973
Query: 609 SDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQ 668
++ +A Q E V+ + +++ L + + Q+ + Q + A+K +Q
Sbjct: 1974 AEEEAARQRKAALEEVE--RLKAKVEEARRLRERAEQESARQLQLAQEA-----AQKRLQ 2026
Query: 669 QIEGAEA-ALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQA-YMRIQELEATLYNA 726
E A A A+ QK EL+ ++Q + L E + ++A ++A R+Q +
Sbjct: 2027 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2086
Query: 727 LQQETVIKFGELLSEKQQ--EELRTAVEKLRRQ--------------MLRKSREYDCQIL 770
Q E + + E+ Q + + A EKLR++ LR+ + D + +
Sbjct: 2087 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-M 2145
Query: 771 QERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSN 806
++ + +Q ++ +E + + Q+++ + + N
Sbjct: 2146 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2181
Score = 86.7 bits (213), Expect = 8e-17
Identities = 130/647 (20%), Positives = 271/647 (41%), Gaps = 55/647 (8%)
Query: 22 ANEDLRTKLTDIQIELHQEKSKVSKLER--EKTQEAKRIRELEQRKHTVLVTELKAKLHE 79
A E ++ L + Q K+ + ++ER K +EA+R+RE +++ + +L + +
Sbjct: 1964 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ 2022
Query: 80 EKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGS--SDKVRTALTIEA 137
++++ + ++Q EQE+ +T++ + +L+ A R + +++ R EA
Sbjct: 2023 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2082
Query: 138 REEARKLFDTERLKL---------LQEIADLKTAKKQVDEALSNMIQADKI-----KAGD 183
+ R++ + ERLK Q A + +K+ ++ + QA++ +A D
Sbjct: 2083 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142
Query: 184 LRSE-HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKE 242
E H+ E + K + E+++ L +++ D L++EL+ + Q+
Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202
Query: 243 ALDEQLFLVK-------EAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATI 295
++E+LF V+ + + + + R + R D ++ + + K++AE A +
Sbjct: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK-MKQVAEEAARL 2261
Query: 296 RKLEDRNTLLGDERNELLKRVRE-TEKQCKPLLE--RNKCLAKRNDELMVSLQRM-EEKL 351
L E L + R EK K ++ + K EL+ + + +E+
Sbjct: 2262 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2321
Query: 352 KAVTKENSEMREKITSHPP-LKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDR 410
+ + ++ +M +++ ++ Q E E LKL+V E D
Sbjct: 2322 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2381
Query: 411 EKL------IRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET----SSMASFRTDRTPAT 460
++ I + HR ++ L + D + ++A ++
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2441
Query: 461 PDDDLDESLAAEESELRFRQLTKEYQALQRAY-----ALLQEQTGGIIDAEREAKAQEQL 515
+ L + + E ++ QL +E QALQ+++ +LLQ + I+ E+ AK ++
Sbjct: 2442 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER--FIEQEK-AKLEQLF 2498
Query: 516 QAEVLRYKAKIEDLEATLAQKGQD-SHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQEL 574
Q EV + + E+ + Q Q+ V + +R E E + +++ E LQQ
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLE 2555
Query: 575 QDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMK 621
Q R Q ELL N L E+ + + S+ V+A Q+ K
Sbjct: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2602
Score = 81.3 bits (199), Expect = 3e-15
Identities = 174/864 (20%), Positives = 359/864 (41%), Gaps = 116/864 (13%)
Query: 6 RNKGEKPEALIVA-LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR 64
R + E+ +A+ +A QA E LR + ++ E+ + KV + +R Q I++ E +
Sbjct: 1205 RRRQEQIQAMPLADSQAVREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQ 1263
Query: 65 KHTVLVTELKAKLHEEKMKELQAVRENLIKQ------HEQEM----SRTVKVRDGEIQRL 114
T +L+ K ++Q+ E++I++ H E+ S+ +K ++R+
Sbjct: 1264 LVTYKA-QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1322
Query: 115 KSA-LCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNM 173
+ A + + ++ R A A E+ R+L + Q + K ++++ E +
Sbjct: 1323 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1382
Query: 174 IQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGY 233
+A A D + + +S QE + +++ SE +I+ + +A +R +E+E+
Sbjct: 1383 EEA----AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438
Query: 234 VQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRI----- 288
++ + Q+ + +L ++ + KR+ A R+ Q +
Sbjct: 1439 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1498
Query: 289 --AELNATIRKLEDRNTL--LGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSL 344
AE A K L L + E +R+R+ E + ++ A+R+ E +
Sbjct: 1499 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1558
Query: 345 QRMEEKLKAVTKENSEMREKIT----SHPPLKKLKSLNDLDQANEEQETEF--------- 391
+R K E S E + ++ + + ++A EE E E
Sbjct: 1559 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1618
Query: 392 -----LKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET 446
L+ + + QQ + + +++K R+ RR K ++ V
Sbjct: 1619 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------------RQ 1664
Query: 447 SSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAE 506
+A ++ + + LAAE+ +R R T++ + ++ LL+E+ + +
Sbjct: 1665 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ---LLEEELARL---Q 1718
Query: 507 REAKA----QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEK 562
REA A +++L+AE+ + +A++E L A+ A+ ++S +K +R + + +
Sbjct: 1719 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--QRLEAEAGRFRE 1776
Query: 563 QEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKE 622
E RL+ ++A+ Q +L E E R+R ++ V A ++ + E
Sbjct: 1777 LAEEAARLRALAEEAKRQRQLAE----EDAARQRAE----------AERVLAEKLAAIGE 1822
Query: 623 GVKDVNIPDLIKQLDILGDNGNLRNE--EQVAIIQASTVLSLAEKWIQQIEGAEAALHQK 680
+ L + +I NE ++A +A L E+ Q E L Q
Sbjct: 1823 ATR------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1876
Query: 681 MMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNAL--QQETVIKFGEL 738
+S++E + KG +E+ L R+Q ++ I L+A+ A + E ++ G +
Sbjct: 1877 RKASDSELE---RQKGLVEDTLRQRRQVEEE----ILALKASFEKAAAGKAELELELGRI 1929
Query: 739 -------LSEKQQEELRTAVEK-LRRQMLRKSREYDCQILQERMELLQQAHQRIRDLED- 789
L K+Q EL A ++ L + R+ RE + ++ + + A QR LE+
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989
Query: 790 -----KTDIQKRQIKDLEEKSNRK 808
K + +R + E++S R+
Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQ 2013
Score = 79.0 bits (193), Expect = 2e-14
Identities = 187/858 (21%), Positives = 335/858 (39%), Gaps = 177/858 (20%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR- 64
R + E L L A E R K T+ +I L +++++ +L R EA + R LE++
Sbjct: 1804 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1862
Query: 65 -KHTVLVTELKAKLHEEKMKELQAVR---ENLIKQHEQEMSRTV-------KVRDGEIQR 113
+H + E A+L + EL+ + E+ ++Q Q + K G+ +
Sbjct: 1863 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE- 1921
Query: 114 LKSALCALRDGSSDKVRTALTIE----------AREEARKLFDTERLKLLQEIADLKTAK 163
L+ L +R + D +R+ E A EE R+ ER++ + +A + A
Sbjct: 1922 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAA 1979
Query: 164 KQVDEALSNMIQADKIKAGDLRS-EHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFS 222
+Q AL ++ K K + R ++ QE+ +++ E +RL E KA +
Sbjct: 1980 RQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2038
Query: 223 LEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLR 282
E+EL+ Q LQ ++ LD+ L EAE RA + +E
Sbjct: 2039 KEQELQ------QTLQQEQSVLDQ---LRGEAEAAR---------RAAEEAEE------- 2073
Query: 283 RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
A + A + R + E E LK+ E + Q + + ++ E
Sbjct: 2074 ------ARVQAEREAAQSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--- 2121
Query: 343 SLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL---DQANEEQETEFLKLQVIE- 398
+E + E + +R+K + ++K K + +A EQE L+LQ+ E
Sbjct: 2122 -----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176
Query: 399 --QQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDS-----MDSETSSMAS 451
Q+N++DE + + +RS ++ + + +E S +++E ++
Sbjct: 2177 DHQKNLLDEELQRLKAEATEAARQRSQ--VEEELFSVRVQMEELSKLKARIEAENRALIL 2234
Query: 452 FRTDRTPATPDDDLDE-----------SLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
D T ++ ++ S+AA+E+ R RQL +E A QRA A
Sbjct: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALA------- 2286
Query: 501 GIIDAEREAKAQEQLQAEVLRYKAKIEDLEAT--LAQKGQDSHWVEDKQLFIKRNQELLE 558
E+ K + Q E R KA+ E L+ LAQ+ Q EDK+ ++ E +
Sbjct: 2287 -----EKMLKEKMQAVQEATRLKAEAELLQQQKELAQE-QARRLQEDKEQMAQQLAEETQ 2340
Query: 559 KIEKQ-EAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQI 617
++ EAE R + +A E L+ R E+ + R+
Sbjct: 2341 GFQRTLEAERQRQLEMSAEA----ERLKLRVAEMSRAQARA------------------- 2377
Query: 618 YCMKEGVKDVNIPDLIKQLDILGDN---GNLRNEEQVAIIQASTVLSLAEKWIQQIEGAE 674
+ + KQ + +G+ L +E+V ++Q
Sbjct: 2378 --------EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT------------------ 2411
Query: 675 AALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIK 734
L + + + D E+ + LE E + +Q ++ +E++ L QET
Sbjct: 2412 --LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2469
Query: 735 FGELLSEKQ---QEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKT 791
LSEK Q E EK + + L + Q L+E + QQ ++ R
Sbjct: 2470 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER------ 2523
Query: 792 DIQKRQIKDLEEKSNRKH 809
+R + +EE R+H
Sbjct: 2524 ---QRLVASMEEARRRQH 2538
Score = 76.3 bits (186), Expect = 1e-13
Identities = 166/800 (20%), Positives = 319/800 (39%), Gaps = 89/800 (11%)
Query: 44 VSKLEREKTQEAKRIRELEQRKHTVLVT---ELKAKLHEEKMKELQAVRENLIKQHEQEM 100
+ KLE+ ++ A + +L+ + T E + HEE++KE QAV L + +
Sbjct: 1049 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1108
Query: 101 SRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTER--------LKL 152
S +K + + + ALRD ++ R R + + ER L+
Sbjct: 1109 S--LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-EVERWRERVAQLLER 1165
Query: 153 LQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDE 212
Q + +++ E L ++ + A L + Q + +I+ D + + ++
Sbjct: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225
Query: 213 IKAKDRIIFSL----EKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGR 268
++ + ++ + EK E Q Q + K+ + QL K ++SP ++ +
Sbjct: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQ 1284
Query: 269 AGDGSEHCSSPDLRRNQKRIAELNA--------TIRKLEDRNTLLGDERNELLKRVRETE 320
+G S DLR + + L + T+R++E+ L +R E +R+ E E
Sbjct: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344
Query: 321 KQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL 380
LE+ + LA+ + + +R ++L+ +E RE+ +K +L
Sbjct: 1345 ----AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1400
Query: 381 DQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDED 440
Q + E E I R E R R + R L+ E
Sbjct: 1401 QQLRQSSEAE------------IQAKARQAEAAERSRLRIEEEIRVVRLQLEA----TER 1444
Query: 441 SMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
+ + R A + + A EE+E RQ+ E Q ++A L +
Sbjct: 1445 QRGGAEGELQALRARAEEA----EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1500
Query: 501 GIIDAERE------AKAQEQLQAEVLRYKAKIEDLEAT--------LAQKGQDSHWVEDK 546
+A RE A + +LQAE + + ++E AQ+ ++ +
Sbjct: 1501 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1560
Query: 547 QLFIKRNQELLEKIEKQEAENHRLQQELQ-DARDQNELLEFRNLELEERERRSPPFNLQI 605
F ++ +L ++++ +L++E + A+ Q E R EE ER + L+
Sbjct: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR----EEAERELERWQLKA 1616
Query: 606 HPFSDGVSALQIYCMKEGV---KDVNIPDLIKQLDILGDNGNLRNE-EQVAIIQASTVLS 661
+ AL++ E V K + + KQ + R + E+ A+ Q
Sbjct: 1617 N------EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1670
Query: 662 LAEKWIQQIEGA---EAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQE 718
EK Q EG A Q+++ L ++ EQ + + LEEEL ++ A + QE
Sbjct: 1671 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQE--RMEL 776
LEA L + V+ + +E EE R+ EK ++++ ++ + ++ +E R+
Sbjct: 1731 LEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRFR-ELAEEAARLRA 1786
Query: 777 LQQAHQRIRDLEDKTDIQKR 796
L + +R R L ++ ++R
Sbjct: 1787 LAEEAKRQRQLAEEDAARQR 1806
Score = 37.7 bits (86), Expect = 0.043
Identities = 42/182 (23%), Positives = 89/182 (48%), Gaps = 16/182 (8%)
Query: 18 ALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTE---LK 74
ALQ + + L + + QEK+K+ +L +++ +A+++RE +QR+ + E L
Sbjct: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527
Query: 75 AKLHEEKMKELQAV-----RENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKV 129
A + E + ++ +A ++ ++Q EQ+ + ++ E QRL+ L L ++
Sbjct: 2528 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL----EEQH 2583
Query: 130 RTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVD---EALSNMIQADKI-KAGDLR 185
R AL A ++ T+ L ++ D A+ + + + L + A ++ +AG L
Sbjct: 2584 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2643
Query: 186 SE 187
+E
Sbjct: 2644 AE 2645
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 92.0 bits (227), Expect = 2e-18
Identities = 188/876 (21%), Positives = 358/876 (40%), Gaps = 132/876 (15%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQ-----EKSKVSKLEREKTQEAKR 57
++ + ++ + +V + A D + + IQ EL Q E +K + + E R
Sbjct: 1374 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1433
Query: 58 IRELEQRKHTVLVTELKAKLHEEKMKELQAVR------ENLIKQHEQEMSRTVKVRDGEI 111
+R E+ + L E + ELQA+R E +Q ++E R + E
Sbjct: 1434 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1493
Query: 112 QR-------LKSALCALRDGSSDKVRTA-----LTIEAREEARKLFDTERLKLLQEIADL 159
QR L S + A + + +K R L ++A E R+L E + Q L
Sbjct: 1494 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1553
Query: 160 KTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRI 219
+TA++ + L + + K L Q A+++++ E+ER ++ + +A++
Sbjct: 1554 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1613
Query: 220 IFSLEKELETQTGYVQKLQLQKEALDEQLFLVK-EAECNMSSPKREIPGRAGDGSEHCSS 278
LE+ + + +L+LQ E + +Q L + EAE +RE R +
Sbjct: 1614 ERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1672
Query: 279 PDLR----RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETE--KQCKPLLERNKC 332
+L Q+++AE A R ++ EL++ ETE +Q + LLE
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQ---------ELIRLRAETEQGEQQRQLLEEE-- 1721
Query: 333 LAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL 392
LA+ E + Q+ +E + K +EM + S +A EE +
Sbjct: 1722 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA------------RAEEESRSTSE 1769
Query: 393 KLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASF 452
K +Q + E R RE + R ++ KR + + E ++
Sbjct: 1770 K----SKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDAARQRA 1815
Query: 453 RTDRTPATPDDDLDESLAAE-ESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKA 511
+R A + E+ + E+E+ ++ E + L+R AE EA
Sbjct: 1816 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL-------------AEDEAFQ 1862
Query: 512 QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLF---IKRNQELLEKI-------E 561
+ +L+ + ++KA IE+ A L +K DS K L +++ +++ E+I E
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQL-RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1921
Query: 562 KQEAENHRLQQEL-------QD---ARDQNELLEFRNLEL---EERERRSPPFNLQIHPF 608
K A L+ EL +D +++Q EL R +L EER RR +Q
Sbjct: 1922 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 1981
Query: 609 SDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQ 668
++ +A Q E V+ + +++ L + + Q+ + Q + A+K +Q
Sbjct: 1982 AEEEAARQRKAALEEVE--RLKAKVEEARRLRERAEQESARQLQLAQEA-----AQKRLQ 2034
Query: 669 QIEGAEA-ALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQA-YMRIQELEATLYNA 726
E A A A+ QK EL+ ++Q + L E + ++A ++A R+Q +
Sbjct: 2035 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2094
Query: 727 LQQETVIKFGELLSEKQQ--EELRTAVEKLRRQ--------------MLRKSREYDCQIL 770
Q E + + E+ Q + + A EKLR++ LR+ + D + +
Sbjct: 2095 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-M 2153
Query: 771 QERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSN 806
++ + +Q ++ +E + + Q+++ + + N
Sbjct: 2154 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2189
Score = 86.7 bits (213), Expect = 8e-17
Identities = 130/647 (20%), Positives = 271/647 (41%), Gaps = 55/647 (8%)
Query: 22 ANEDLRTKLTDIQIELHQEKSKVSKLER--EKTQEAKRIRELEQRKHTVLVTELKAKLHE 79
A E ++ L + Q K+ + ++ER K +EA+R+RE +++ + +L + +
Sbjct: 1972 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ 2030
Query: 80 EKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGS--SDKVRTALTIEA 137
++++ + ++Q EQE+ +T++ + +L+ A R + +++ R EA
Sbjct: 2031 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2090
Query: 138 REEARKLFDTERLKL---------LQEIADLKTAKKQVDEALSNMIQADKI-----KAGD 183
+ R++ + ERLK Q A + +K+ ++ + QA++ +A D
Sbjct: 2091 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2150
Query: 184 LRSE-HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKE 242
E H+ E + K + E+++ L +++ D L++EL+ + Q+
Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2210
Query: 243 ALDEQLFLVK-------EAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATI 295
++E+LF V+ + + + + R + R D ++ + + K++AE A +
Sbjct: 2211 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK-MKQVAEEAARL 2269
Query: 296 RKLEDRNTLLGDERNELLKRVRE-TEKQCKPLLE--RNKCLAKRNDELMVSLQRM-EEKL 351
L E L + R EK K ++ + K EL+ + + +E+
Sbjct: 2270 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2329
Query: 352 KAVTKENSEMREKITSHPP-LKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDR 410
+ + ++ +M +++ ++ Q E E LKL+V E D
Sbjct: 2330 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2389
Query: 411 EKL------IRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET----SSMASFRTDRTPAT 460
++ I + HR ++ L + D + ++A ++
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2449
Query: 461 PDDDLDESLAAEESELRFRQLTKEYQALQRAY-----ALLQEQTGGIIDAEREAKAQEQL 515
+ L + + E ++ QL +E QALQ+++ +LLQ + I+ E+ AK ++
Sbjct: 2450 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER--FIEQEK-AKLEQLF 2506
Query: 516 QAEVLRYKAKIEDLEATLAQKGQD-SHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQEL 574
Q EV + + E+ + Q Q+ V + +R E E + +++ E LQQ
Sbjct: 2507 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLE 2563
Query: 575 QDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMK 621
Q R Q ELL N L E+ + + S+ V+A Q+ K
Sbjct: 2564 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2610
Score = 81.3 bits (199), Expect = 3e-15
Identities = 174/864 (20%), Positives = 359/864 (41%), Gaps = 116/864 (13%)
Query: 6 RNKGEKPEALIVA-LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR 64
R + E+ +A+ +A QA E LR + ++ E+ + KV + +R Q I++ E +
Sbjct: 1213 RRRQEQIQAMPLADSQAVREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQ 1271
Query: 65 KHTVLVTELKAKLHEEKMKELQAVRENLIKQ------HEQEM----SRTVKVRDGEIQRL 114
T +L+ K ++Q+ E++I++ H E+ S+ +K ++R+
Sbjct: 1272 LVTYKA-QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1330
Query: 115 KSA-LCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNM 173
+ A + + ++ R A A E+ R+L + Q + K ++++ E +
Sbjct: 1331 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1390
Query: 174 IQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGY 233
+A A D + + +S QE + +++ SE +I+ + +A +R +E+E+
Sbjct: 1391 EEA----AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446
Query: 234 VQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRI----- 288
++ + Q+ + +L ++ + KR+ A R+ Q +
Sbjct: 1447 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1506
Query: 289 --AELNATIRKLEDRNTL--LGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSL 344
AE A K L L + E +R+R+ E + ++ A+R+ E +
Sbjct: 1507 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1566
Query: 345 QRMEEKLKAVTKENSEMREKIT----SHPPLKKLKSLNDLDQANEEQETEF--------- 391
+R K E S E + ++ + + ++A EE E E
Sbjct: 1567 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1626
Query: 392 -----LKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET 446
L+ + + QQ + + +++K R+ RR K ++ V
Sbjct: 1627 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------------RQ 1672
Query: 447 SSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAE 506
+A ++ + + LAAE+ +R R T++ + ++ LL+E+ + +
Sbjct: 1673 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ---LLEEELARL---Q 1726
Query: 507 REAKA----QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEK 562
REA A +++L+AE+ + +A++E L A+ A+ ++S +K +R + + +
Sbjct: 1727 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--QRLEAEAGRFRE 1784
Query: 563 QEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKE 622
E RL+ ++A+ Q +L E E R+R ++ V A ++ + E
Sbjct: 1785 LAEEAARLRALAEEAKRQRQLAE----EDAARQRAE----------AERVLAEKLAAIGE 1830
Query: 623 GVKDVNIPDLIKQLDILGDNGNLRNE--EQVAIIQASTVLSLAEKWIQQIEGAEAALHQK 680
+ L + +I NE ++A +A L E+ Q E L Q
Sbjct: 1831 ATR------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1884
Query: 681 MMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNAL--QQETVIKFGEL 738
+S++E + KG +E+ L R+Q ++ I L+A+ A + E ++ G +
Sbjct: 1885 RKASDSELE---RQKGLVEDTLRQRRQVEEE----ILALKASFEKAAAGKAELELELGRI 1937
Query: 739 -------LSEKQQEELRTAVEK-LRRQMLRKSREYDCQILQERMELLQQAHQRIRDLED- 789
L K+Q EL A ++ L + R+ RE + ++ + + A QR LE+
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997
Query: 790 -----KTDIQKRQIKDLEEKSNRK 808
K + +R + E++S R+
Sbjct: 1998 ERLKAKVEEARRLRERAEQESARQ 2021
Score = 79.0 bits (193), Expect = 2e-14
Identities = 187/858 (21%), Positives = 335/858 (39%), Gaps = 177/858 (20%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR- 64
R + E L L A E R K T+ +I L +++++ +L R EA + R LE++
Sbjct: 1812 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1870
Query: 65 -KHTVLVTELKAKLHEEKMKELQAVR---ENLIKQHEQEMSRTV-------KVRDGEIQR 113
+H + E A+L + EL+ + E+ ++Q Q + K G+ +
Sbjct: 1871 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE- 1929
Query: 114 LKSALCALRDGSSDKVRTALTIE----------AREEARKLFDTERLKLLQEIADLKTAK 163
L+ L +R + D +R+ E A EE R+ ER++ + +A + A
Sbjct: 1930 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAA 1987
Query: 164 KQVDEALSNMIQADKIKAGDLRS-EHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFS 222
+Q AL ++ K K + R ++ QE+ +++ E +RL E KA +
Sbjct: 1988 RQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2046
Query: 223 LEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLR 282
E+EL+ Q LQ ++ LD+ L EAE RA + +E
Sbjct: 2047 KEQELQ------QTLQQEQSVLDQ---LRGEAEAAR---------RAAEEAEE------- 2081
Query: 283 RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
A + A + R + E E LK+ E + Q + + ++ E
Sbjct: 2082 ------ARVQAEREAAQSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--- 2129
Query: 343 SLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL---DQANEEQETEFLKLQVIE- 398
+E + E + +R+K + ++K K + +A EQE L+LQ+ E
Sbjct: 2130 -----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2184
Query: 399 --QQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDS-----MDSETSSMAS 451
Q+N++DE + + +RS ++ + + +E S +++E ++
Sbjct: 2185 DHQKNLLDEELQRLKAEATEAARQRSQ--VEEELFSVRVQMEELSKLKARIEAENRALIL 2242
Query: 452 FRTDRTPATPDDDLDE-----------SLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
D T ++ ++ S+AA+E+ R RQL +E A QRA A
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALA------- 2294
Query: 501 GIIDAEREAKAQEQLQAEVLRYKAKIEDLEAT--LAQKGQDSHWVEDKQLFIKRNQELLE 558
E+ K + Q E R KA+ E L+ LAQ+ Q EDK+ ++ E +
Sbjct: 2295 -----EKMLKEKMQAVQEATRLKAEAELLQQQKELAQE-QARRLQEDKEQMAQQLAEETQ 2348
Query: 559 KIEKQ-EAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQI 617
++ EAE R + +A E L+ R E+ + R+
Sbjct: 2349 GFQRTLEAERQRQLEMSAEA----ERLKLRVAEMSRAQARA------------------- 2385
Query: 618 YCMKEGVKDVNIPDLIKQLDILGDN---GNLRNEEQVAIIQASTVLSLAEKWIQQIEGAE 674
+ + KQ + +G+ L +E+V ++Q
Sbjct: 2386 --------EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT------------------ 2419
Query: 675 AALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIK 734
L + + + D E+ + LE E + +Q ++ +E++ L QET
Sbjct: 2420 --LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2477
Query: 735 FGELLSEKQ---QEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKT 791
LSEK Q E EK + + L + Q L+E + QQ ++ R
Sbjct: 2478 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER------ 2531
Query: 792 DIQKRQIKDLEEKSNRKH 809
+R + +EE R+H
Sbjct: 2532 ---QRLVASMEEARRRQH 2546
Score = 76.3 bits (186), Expect = 1e-13
Identities = 166/800 (20%), Positives = 319/800 (39%), Gaps = 89/800 (11%)
Query: 44 VSKLEREKTQEAKRIRELEQRKHTVLVT---ELKAKLHEEKMKELQAVRENLIKQHEQEM 100
+ KLE+ ++ A + +L+ + T E + HEE++KE QAV L + +
Sbjct: 1057 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1116
Query: 101 SRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTER--------LKL 152
S +K + + + ALRD ++ R R + + ER L+
Sbjct: 1117 S--LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-EVERWRERVAQLLER 1173
Query: 153 LQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDE 212
Q + +++ E L ++ + A L + Q + +I+ D + + ++
Sbjct: 1174 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1233
Query: 213 IKAKDRIIFSL----EKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGR 268
++ + ++ + EK E Q Q + K+ + QL K ++SP ++ +
Sbjct: 1234 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQ 1292
Query: 269 AGDGSEHCSSPDLRRNQKRIAELNA--------TIRKLEDRNTLLGDERNELLKRVRETE 320
+G S DLR + + L + T+R++E+ L +R E +R+ E E
Sbjct: 1293 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1352
Query: 321 KQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL 380
LE+ + LA+ + + +R ++L+ +E RE+ +K +L
Sbjct: 1353 ----AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1408
Query: 381 DQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDED 440
Q + E E I R E R R + R L+ E
Sbjct: 1409 QQLRQSSEAE------------IQAKARQAEAAERSRLRIEEEIRVVRLQLEA----TER 1452
Query: 441 SMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
+ + R A + + A EE+E RQ+ E Q ++A L +
Sbjct: 1453 QRGGAEGELQALRARAEEA----EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1508
Query: 501 GIIDAERE------AKAQEQLQAEVLRYKAKIEDLEAT--------LAQKGQDSHWVEDK 546
+A RE A + +LQAE + + ++E AQ+ ++ +
Sbjct: 1509 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1568
Query: 547 QLFIKRNQELLEKIEKQEAENHRLQQELQ-DARDQNELLEFRNLELEERERRSPPFNLQI 605
F ++ +L ++++ +L++E + A+ Q E R EE ER + L+
Sbjct: 1569 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR----EEAERELERWQLKA 1624
Query: 606 HPFSDGVSALQIYCMKEGV---KDVNIPDLIKQLDILGDNGNLRNE-EQVAIIQASTVLS 661
+ AL++ E V K + + KQ + R + E+ A+ Q
Sbjct: 1625 N------EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1678
Query: 662 LAEKWIQQIEGA---EAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQE 718
EK Q EG A Q+++ L ++ EQ + + LEEEL ++ A + QE
Sbjct: 1679 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQE--RMEL 776
LEA L + V+ + +E EE R+ EK ++++ ++ + ++ +E R+
Sbjct: 1739 LEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRFR-ELAEEAARLRA 1794
Query: 777 LQQAHQRIRDLEDKTDIQKR 796
L + +R R L ++ ++R
Sbjct: 1795 LAEEAKRQRQLAEEDAARQR 1814
Score = 37.7 bits (86), Expect = 0.043
Identities = 42/182 (23%), Positives = 89/182 (48%), Gaps = 16/182 (8%)
Query: 18 ALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTE---LK 74
ALQ + + L + + QEK+K+ +L +++ +A+++RE +QR+ + E L
Sbjct: 2476 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2535
Query: 75 AKLHEEKMKELQAV-----RENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKV 129
A + E + ++ +A ++ ++Q EQ+ + ++ E QRL+ L L ++
Sbjct: 2536 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL----EEQH 2591
Query: 130 RTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVD---EALSNMIQADKI-KAGDLR 185
R AL A ++ T+ L ++ D A+ + + + L + A ++ +AG L
Sbjct: 2592 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2651
Query: 186 SE 187
+E
Sbjct: 2652 AE 2653
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 92.0 bits (227), Expect = 2e-18
Identities = 188/876 (21%), Positives = 358/876 (40%), Gaps = 132/876 (15%)
Query: 3 KKGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQ-----EKSKVSKLEREKTQEAKR 57
++ + ++ + +V + A D + + IQ EL Q E +K + + E R
Sbjct: 1415 REAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR 1474
Query: 58 IRELEQRKHTVLVTELKAKLHEEKMKELQAVR------ENLIKQHEQEMSRTVKVRDGEI 111
+R E+ + L E + ELQA+R E +Q ++E R + E
Sbjct: 1475 LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1534
Query: 112 QR-------LKSALCALRDGSSDKVRTA-----LTIEAREEARKLFDTERLKLLQEIADL 159
QR L S + A + + +K R L ++A E R+L E + Q L
Sbjct: 1535 QRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1594
Query: 160 KTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRI 219
+TA++ + L + + K L Q A+++++ E+ER ++ + +A++
Sbjct: 1595 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1654
Query: 220 IFSLEKELETQTGYVQKLQLQKEALDEQLFLVK-EAECNMSSPKREIPGRAGDGSEHCSS 278
LE+ + + +L+LQ E + +Q L + EAE +RE R +
Sbjct: 1655 ERELER-WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1713
Query: 279 PDLR----RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETE--KQCKPLLERNKC 332
+L Q+++AE A R ++ EL++ ETE +Q + LLE
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQ---------ELIRLRAETEQGEQQRQLLEEE-- 1762
Query: 333 LAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFL 392
LA+ E + Q+ +E + K +EM + S +A EE +
Sbjct: 1763 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA------------RAEEESRSTSE 1810
Query: 393 KLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASF 452
K +Q + E R RE + R ++ KR + + E ++
Sbjct: 1811 K----SKQRLEAEAGRFRELAEEAARLRALAEEAKR----------QRQLAEEDAARQRA 1856
Query: 453 RTDRTPATPDDDLDESLAAE-ESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKA 511
+R A + E+ + E+E+ ++ E + L+R AE EA
Sbjct: 1857 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRL-------------AEDEAFQ 1903
Query: 512 QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLF---IKRNQELLEKI-------E 561
+ +L+ + ++KA IE+ A L +K DS K L +++ +++ E+I E
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQL-RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFE 1962
Query: 562 KQEAENHRLQQEL-------QD---ARDQNELLEFRNLEL---EERERRSPPFNLQIHPF 608
K A L+ EL +D +++Q EL R +L EER RR +Q
Sbjct: 1963 KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLA 2022
Query: 609 SDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQ 668
++ +A Q E V+ + +++ L + + Q+ + Q + A+K +Q
Sbjct: 2023 AEEEAARQRKAALEEVE--RLKAKVEEARRLRERAEQESARQLQLAQEA-----AQKRLQ 2075
Query: 669 QIEGAEA-ALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQA-YMRIQELEATLYNA 726
E A A A+ QK EL+ ++Q + L E + ++A ++A R+Q +
Sbjct: 2076 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSR 2135
Query: 727 LQQETVIKFGELLSEKQQ--EELRTAVEKLRRQ--------------MLRKSREYDCQIL 770
Q E + + E+ Q + + A EKLR++ LR+ + D + +
Sbjct: 2136 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAE-M 2194
Query: 771 QERMELLQQAHQRIRDLEDKTDIQKRQIKDLEEKSN 806
++ + +Q ++ +E + + Q+++ + + N
Sbjct: 2195 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2230
Score = 86.7 bits (213), Expect = 8e-17
Identities = 130/647 (20%), Positives = 271/647 (41%), Gaps = 55/647 (8%)
Query: 22 ANEDLRTKLTDIQIELHQEKSKVSKLER--EKTQEAKRIRELEQRKHTVLVTELKAKLHE 79
A E ++ L + Q K+ + ++ER K +EA+R+RE +++ + +L + +
Sbjct: 2013 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE-SARQLQLAQEAAQ 2071
Query: 80 EKMKELQAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGS--SDKVRTALTIEA 137
++++ + ++Q EQE+ +T++ + +L+ A R + +++ R EA
Sbjct: 2072 KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREA 2131
Query: 138 REEARKLFDTERLKL---------LQEIADLKTAKKQVDEALSNMIQADKI-----KAGD 183
+ R++ + ERLK Q A + +K+ ++ + QA++ +A D
Sbjct: 2132 AQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2191
Query: 184 LRSE-HQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQLQKE 242
E H+ E + K + E+++ L +++ D L++EL+ + Q+
Sbjct: 2192 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2251
Query: 243 ALDEQLFLVK-------EAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAELNATI 295
++E+LF V+ + + + + R + R D ++ + + K++AE A +
Sbjct: 2252 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK-MKQVAEEAARL 2310
Query: 296 RKLEDRNTLLGDERNELLKRVRE-TEKQCKPLLE--RNKCLAKRNDELMVSLQRM-EEKL 351
L E L + R EK K ++ + K EL+ + + +E+
Sbjct: 2311 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2370
Query: 352 KAVTKENSEMREKITSHPP-LKKLKSLNDLDQANEEQETEFLKLQVIEQQNIIDELTRDR 410
+ + ++ +M +++ ++ Q E E LKL+V E D
Sbjct: 2371 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2430
Query: 411 EKL------IRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET----SSMASFRTDRTPAT 460
++ I + HR ++ L + D + ++A ++
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2490
Query: 461 PDDDLDESLAAEESELRFRQLTKEYQALQRAY-----ALLQEQTGGIIDAEREAKAQEQL 515
+ L + + E ++ QL +E QALQ+++ +LLQ + I+ E+ AK ++
Sbjct: 2491 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRER--FIEQEK-AKLEQLF 2547
Query: 516 QAEVLRYKAKIEDLEATLAQKGQD-SHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQEL 574
Q EV + + E+ + Q Q+ V + +R E E + +++ E LQQ
Sbjct: 2548 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEE---LQQLE 2604
Query: 575 QDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMK 621
Q R Q ELL N L E+ + + S+ V+A Q+ K
Sbjct: 2605 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATK 2651
Score = 81.3 bits (199), Expect = 3e-15
Identities = 174/864 (20%), Positives = 359/864 (41%), Gaps = 116/864 (13%)
Query: 6 RNKGEKPEALIVA-LQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR 64
R + E+ +A+ +A QA E LR + ++ E+ + KV + +R Q I++ E +
Sbjct: 1254 RRRQEQIQAMPLADSQAVREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQ 1312
Query: 65 KHTVLVTELKAKLHEEKMKELQAVRENLIKQ------HEQEM----SRTVKVRDGEIQRL 114
T +L+ K ++Q+ E++I++ H E+ S+ +K ++R+
Sbjct: 1313 LVTYKA-QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1371
Query: 115 KSA-LCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVDEALSNM 173
+ A + + ++ R A A E+ R+L + Q + K ++++ E +
Sbjct: 1372 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRR 1431
Query: 174 IQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGY 233
+A A D + + +S QE + +++ SE +I+ + +A +R +E+E+
Sbjct: 1432 EEA----AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487
Query: 234 VQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRI----- 288
++ + Q+ + +L ++ + KR+ A R+ Q +
Sbjct: 1488 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1547
Query: 289 --AELNATIRKLEDRNTL--LGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMVSL 344
AE A K L L + E +R+R+ E + ++ A+R+ E +
Sbjct: 1548 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1607
Query: 345 QRMEEKLKAVTKENSEMREKIT----SHPPLKKLKSLNDLDQANEEQETEF--------- 391
+R K E S E + ++ + + ++A EE E E
Sbjct: 1608 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1667
Query: 392 -----LKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSET 446
L+ + + QQ + + +++K R+ RR K ++ V
Sbjct: 1668 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------------RQ 1713
Query: 447 SSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAE 506
+A ++ + + LAAE+ +R R T++ + ++ LL+E+ + +
Sbjct: 1714 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ---LLEEELARL---Q 1767
Query: 507 REAKA----QEQLQAEVLRYKAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEKIEK 562
REA A +++L+AE+ + +A++E L A+ A+ ++S +K +R + + +
Sbjct: 1768 REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--QRLEAEAGRFRE 1825
Query: 563 QEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKE 622
E RL+ ++A+ Q +L E E R+R ++ V A ++ + E
Sbjct: 1826 LAEEAARLRALAEEAKRQRQLAE----EDAARQRAE----------AERVLAEKLAAIGE 1871
Query: 623 GVKDVNIPDLIKQLDILGDNGNLRNE--EQVAIIQASTVLSLAEKWIQQIEGAEAALHQK 680
+ L + +I NE ++A +A L E+ Q E L Q
Sbjct: 1872 ATR------LKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQL 1925
Query: 681 MMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNAL--QQETVIKFGEL 738
+S++E + KG +E+ L R+Q ++ I L+A+ A + E ++ G +
Sbjct: 1926 RKASDSELE---RQKGLVEDTLRQRRQVEEE----ILALKASFEKAAAGKAELELELGRI 1978
Query: 739 -------LSEKQQEELRTAVEK-LRRQMLRKSREYDCQILQERMELLQQAHQRIRDLED- 789
L K+Q EL A ++ L + R+ RE + ++ + + A QR LE+
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038
Query: 790 -----KTDIQKRQIKDLEEKSNRK 808
K + +R + E++S R+
Sbjct: 2039 ERLKAKVEEARRLRERAEQESARQ 2062
Score = 79.0 bits (193), Expect = 2e-14
Identities = 187/858 (21%), Positives = 335/858 (39%), Gaps = 177/858 (20%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR- 64
R + E L L A E R K T+ +I L +++++ +L R EA + R LE++
Sbjct: 1853 RQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1911
Query: 65 -KHTVLVTELKAKLHEEKMKELQAVR---ENLIKQHEQEMSRTV-------KVRDGEIQR 113
+H + E A+L + EL+ + E+ ++Q Q + K G+ +
Sbjct: 1912 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE- 1970
Query: 114 LKSALCALRDGSSDKVRTALTIE----------AREEARKLFDTERLKLLQEIADLKTAK 163
L+ L +R + D +R+ E A EE R+ ER++ + +A + A
Sbjct: 1971 LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAA 2028
Query: 164 KQVDEALSNMIQADKIKAGDLRS-EHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFS 222
+Q AL ++ K K + R ++ QE+ +++ E +RL E KA +
Sbjct: 2029 RQRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQ 2087
Query: 223 LEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLR 282
E+EL+ Q LQ ++ LD+ L EAE RA + +E
Sbjct: 2088 KEQELQ------QTLQQEQSVLDQ---LRGEAEAAR---------RAAEEAEE------- 2122
Query: 283 RNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
A + A + R + E E LK+ E + Q + + ++ E
Sbjct: 2123 ------ARVQAEREAAQSRRQV---EEAERLKQSAEEQAQARAQAQAAAEKLRKEAE--- 2170
Query: 343 SLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL---DQANEEQETEFLKLQVIE- 398
+E + E + +R+K + ++K K + +A EQE L+LQ+ E
Sbjct: 2171 -----QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2225
Query: 399 --QQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDS-----MDSETSSMAS 451
Q+N++DE + + +RS ++ + + +E S +++E ++
Sbjct: 2226 DHQKNLLDEELQRLKAEATEAARQRSQ--VEEELFSVRVQMEELSKLKARIEAENRALIL 2283
Query: 452 FRTDRTPATPDDDLDE-----------SLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
D T ++ ++ S+AA+E+ R RQL +E A QRA A
Sbjct: 2284 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAA-RLRQLAEEDLAQQRALA------- 2335
Query: 501 GIIDAEREAKAQEQLQAEVLRYKAKIEDLEAT--LAQKGQDSHWVEDKQLFIKRNQELLE 558
E+ K + Q E R KA+ E L+ LAQ+ Q EDK+ ++ E +
Sbjct: 2336 -----EKMLKEKMQAVQEATRLKAEAELLQQQKELAQE-QARRLQEDKEQMAQQLAEETQ 2389
Query: 559 KIEKQ-EAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQI 617
++ EAE R + +A E L+ R E+ + R+
Sbjct: 2390 GFQRTLEAERQRQLEMSAEA----ERLKLRVAEMSRAQARA------------------- 2426
Query: 618 YCMKEGVKDVNIPDLIKQLDILGDN---GNLRNEEQVAIIQASTVLSLAEKWIQQIEGAE 674
+ + KQ + +G+ L +E+V ++Q
Sbjct: 2427 --------EEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT------------------ 2460
Query: 675 AALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQELEATLYNALQQETVIK 734
L + + + D E+ + LE E + +Q ++ +E++ L QET
Sbjct: 2461 --LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQAL 2518
Query: 735 FGELLSEKQ---QEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDKT 791
LSEK Q E EK + + L + Q L+E + QQ ++ R
Sbjct: 2519 QQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER------ 2572
Query: 792 DIQKRQIKDLEEKSNRKH 809
+R + +EE R+H
Sbjct: 2573 ---QRLVASMEEARRRQH 2587
Score = 76.3 bits (186), Expect = 1e-13
Identities = 166/800 (20%), Positives = 319/800 (39%), Gaps = 89/800 (11%)
Query: 44 VSKLEREKTQEAKRIRELEQRKHTVLVT---ELKAKLHEEKMKELQAVRENLIKQHEQEM 100
+ KLE+ ++ A + +L+ + T E + HEE++KE QAV L + +
Sbjct: 1098 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1157
Query: 101 SRTVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTER--------LKL 152
S +K + + + ALRD ++ R R + + ER L+
Sbjct: 1158 S--LKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-EVERWRERVAQLLER 1214
Query: 153 LQEIADLKTAKKQVDEALSNMIQADKIKAGDLRSEHQSHQEAISKIKWESERDIRRLMDE 212
Q + +++ E L ++ + A L + Q + +I+ D + + ++
Sbjct: 1215 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1274
Query: 213 IKAKDRIIFSL----EKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGR 268
++ + ++ + EK E Q Q + K+ + QL K ++SP ++ +
Sbjct: 1275 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKD-YELQLVTYKAQLEPVASPAKKPKVQ 1333
Query: 269 AGDGSEHCSSPDLRRNQKRIAELNA--------TIRKLEDRNTLLGDERNELLKRVRETE 320
+G S DLR + + L + T+R++E+ L +R E +R+ E E
Sbjct: 1334 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1393
Query: 321 KQCKPLLERNKCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKITSHPPLKKLKSLNDL 380
LE+ + LA+ + + +R ++L+ +E RE+ +K +L
Sbjct: 1394 ----AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1449
Query: 381 DQANEEQETEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDED 440
Q + E E I R E R R + R L+ E
Sbjct: 1450 QQLRQSSEAE------------IQAKARQAEAAERSRLRIEEEIRVVRLQLEA----TER 1493
Query: 441 SMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTG 500
+ + R A + + A EE+E RQ+ E Q ++A L +
Sbjct: 1494 QRGGAEGELQALRARAEEA----EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1549
Query: 501 GIIDAERE------AKAQEQLQAEVLRYKAKIEDLEAT--------LAQKGQDSHWVEDK 546
+A RE A + +LQAE + + ++E AQ+ ++ +
Sbjct: 1550 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1609
Query: 547 QLFIKRNQELLEKIEKQEAENHRLQQELQ-DARDQNELLEFRNLELEERERRSPPFNLQI 605
F ++ +L ++++ +L++E + A+ Q E R EE ER + L+
Sbjct: 1610 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR----EEAERELERWQLKA 1665
Query: 606 HPFSDGVSALQIYCMKEGV---KDVNIPDLIKQLDILGDNGNLRNE-EQVAIIQASTVLS 661
+ AL++ E V K + + KQ + R + E+ A+ Q
Sbjct: 1666 N------EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1719
Query: 662 LAEKWIQQIEGA---EAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRIQE 718
EK Q EG A Q+++ L ++ EQ + + LEEEL ++ A + QE
Sbjct: 1720 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779
Query: 719 LEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQE--RMEL 776
LEA L + V+ + +E EE R+ EK ++++ ++ + ++ +E R+
Sbjct: 1780 LEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAEAGRFR-ELAEEAARLRA 1835
Query: 777 LQQAHQRIRDLEDKTDIQKR 796
L + +R R L ++ ++R
Sbjct: 1836 LAEEAKRQRQLAEEDAARQR 1855
Score = 37.7 bits (86), Expect = 0.043
Identities = 42/182 (23%), Positives = 89/182 (48%), Gaps = 16/182 (8%)
Query: 18 ALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRKHTVLVTE---LK 74
ALQ + + L + + QEK+K+ +L +++ +A+++RE +QR+ + E L
Sbjct: 2517 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2576
Query: 75 AKLHEEKMKELQAV-----RENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRDGSSDKV 129
A + E + ++ +A ++ ++Q EQ+ + ++ E QRL+ L L ++
Sbjct: 2577 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL----EEQH 2632
Query: 130 RTALTIEAREEARKLFDTERLKLLQEIADLKTAKKQVD---EALSNMIQADKI-KAGDLR 185
R AL A ++ T+ L ++ D A+ + + + L + A ++ +AG L
Sbjct: 2633 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2692
Query: 186 SE 187
+E
Sbjct: 2693 AE 2694
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 91.7 bits (226), Expect = 3e-18
Identities = 170/860 (19%), Positives = 360/860 (41%), Gaps = 119/860 (13%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQR- 64
++K E +AL + LQ ++L+ ++ +++ E+ E++ +K E++++ ++ + E+ +R
Sbjct: 1097 QSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1156
Query: 65 KHTVLVTELKAKLHEEKMKELQAVRENLIK---QHEQEMSRTVKVRDGEIQRLKSALCAL 121
+ T + ++++++ E Q +R +L + QHE + K + L + L
Sbjct: 1157 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1216
Query: 122 RDGSS--DKVRTALTIEAREEARKLFDTERLK---------LLQEIADLKTAKKQVDEAL 170
+ +K ++ + +E + A + + K L ++++LK+ K++ + L
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS-KEEEQQRL 1275
Query: 171 SNMIQADK----IKAGDLRSEHQSHQEAISKIK-------WESERDIRRLMDEIKAKDRI 219
N + A + ++G+ + + +S++ + E R+L +EIKAK+ +
Sbjct: 1276 INDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNAL 1335
Query: 220 IFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEHCSSP 279
+L+ ++ + ++E+ E + +A ++ + + A +E
Sbjct: 1336 AHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEA 1395
Query: 280 D------LRRNQKRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCL 333
L+ ++ + +NA LE L +E +L+ V T C L ++ +
Sbjct: 1396 KKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNF 1455
Query: 334 AKRNDELMVSLQRMEEKLKAVTKENSEM-----REKITSHPPLKKLKSLNDLDQANEEQE 388
K E + +L+A KE + + K L +L++L + N +QE
Sbjct: 1456 DKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKR-ENKNLQQE 1514
Query: 389 TEFLKLQVIEQQNIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSM---DSE 445
L Q+ E I EL EK+ ++ + + + + ++E + E
Sbjct: 1515 ISDLTEQIAEGGKRIHEL----EKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLE 1570
Query: 446 TSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQALQR--AYALLQEQTGGII 503
+ + S DR A D+++D+ + Q T + + R A L ++ G +
Sbjct: 1571 LNQVKS-EVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1629
Query: 504 DAEREAKAQEQLQAEVLRY----KAKIEDLEATLAQKGQDSHWVEDKQLFIKRNQELLEK 559
+ E + ++ AE LR + ++D + L + ++++ ++R LL+
Sbjct: 1630 EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689
Query: 560 --------IEKQEAENHRLQQELQDARDQNELLEFRNLELEERERRSPPFNLQIHPFSDG 611
+E+ E +QEL DA ++ +LL +N L +++
Sbjct: 1690 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKK----------LETD 1739
Query: 612 VSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIE 671
+S +Q + DIL + N + + AI A+ + +K
Sbjct: 1740 ISQMQG----------------EMEDILQEARNAEEKAKKAITDAAMMAEELKK------ 1777
Query: 672 GAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQ-ALDQAYMRIQELEATLYNALQQE 730
E + ++ +MEQ K L+ LD +Q AL +IQ+LEA + L+ E
Sbjct: 1778 --EQDTSAHLERMKKNMEQTVKD---LQLRLDEAEQLALKGGKKQIQKLEARV-RELEGE 1831
Query: 731 TVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIRDLEDK 790
E +Q+ AV+ LR+ R+ +E Q ++R +L R++DL DK
Sbjct: 1832 V---------ESEQKRNAEAVKGLRKHE-RRVKELTYQTEEDRKNIL-----RLQDLVDK 1876
Query: 791 TDIQ----KRQIKDLEEKSN 806
+ KRQ ++ EE+SN
Sbjct: 1877 LQAKVKSYKRQAEEAEEQSN 1896
Score = 89.0 bits (219), Expect = 2e-17
Identities = 179/895 (20%), Positives = 363/895 (40%), Gaps = 122/895 (13%)
Query: 4 KGRNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQ 63
K K ++ E +V L DL+ ++ L + + +L + K Q +I+E+ +
Sbjct: 871 KSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTE 930
Query: 64 RKH-----TVLVTELKAKLHEE----------------KMKELQAVRENLIKQHEQEMSR 102
R +T K KL +E K+++ + EN +K +EM+
Sbjct: 931 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAG 990
Query: 103 TVKVRDGEIQRLKSALCALRDGSSDKVRTALTIEAREEARKLFDTERLKLLQEIADLKTA 162
D I +L AL++ +T ++A E+ ++KL Q++ DL+ +
Sbjct: 991 L----DETIAKLTKEKKALQEAHQ---QTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGS 1043
Query: 163 KKQVDEALSNMIQADKIKAGDLRSEHQS-------HQEAISKIKWESERDIRRLMDEIKA 215
+Q + ++ +A + GDL+ +S Q+ K+K + E +I L +I+
Sbjct: 1044 LEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLK-KKEFEISNLQSKIED 1102
Query: 216 KDRIIFSLEKELETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREIPGRAGDGSEH 275
+ + L+K+++ +++L+ + EA ++ ++S EI R +
Sbjct: 1103 EQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG-G 1161
Query: 276 CSSPDLRRNQKRIAELNATIRKLEDRNTLLGDERNELLKR-----VRETEKQCKPLLERN 330
+S + N+KR AE R LE+ TL + L++ V E +Q L
Sbjct: 1162 ATSAQIEMNKKREAEFQKMRRDLEEA-TLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1220
Query: 331 KCLAKRNDELMVSLQRMEEKLKAVTKENSEMREKI-TSHPPLKKLKS--------LNDLD 381
+ L K E+ + + + ++ V+K + + T L +LKS +NDL
Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280
Query: 382 QANEEQETEF--LKLQVIEQQNIIDELTRDREKLIRRRKH--RRSSKPIK---------- 427
+TE Q+ E++ ++ +L+R ++ ++ + R+ + IK
Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQ 1340
Query: 428 --RPVLDPFIGYDEDSMDSETS---SMASFRTDRTPATPDDDLDESLAAEESELRFRQLT 482
R D E+ +S+ +++ T+ + D EE E ++L
Sbjct: 1341 SSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLA 1400
Query: 483 KEYQA--------------LQRAYALLQEQTGGI-IDAERE-------AKAQEQLQAEVL 520
+ QA L++ LQ + + +D ER K Q +
Sbjct: 1401 QRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILA 1460
Query: 521 RYKAKIEDLEATLAQKGQDSHWVEDKQLFIKR-NQELLEKIEKQEAENHRLQQELQDARD 579
+K K E+ A L +++ + + IK +E L+++E + EN LQQE+ D +
Sbjct: 1461 EWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1520
Query: 580 QNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDIL 639
Q R ELE+ +++ ++ + A + +EG K + I + Q+
Sbjct: 1521 QIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEH--EEG-KILRIQLELNQVKSE 1577
Query: 640 GDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLE 699
D +E++ L I+ +E ++ L ++ + K++G L
Sbjct: 1578 VDRKIAEKDEEID--------QLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLN 1629
Query: 700 E---ELDYRKQALDQAYMR-------IQELEATLYNALQQETVIKFGELLSEKQQEELRT 749
E +L++ + +A +++ + L +AL+ + +K + E++ L+
Sbjct: 1630 EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQA 1689
Query: 750 AVEKLR-----RQMLRKSREYDCQILQERMELLQQAHQRIRDLEDK--TDIQKRQ 797
+E+LR + RK E + ER++LL + + + + K TDI + Q
Sbjct: 1690 EIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQ 1744
Score = 73.6 bits (179), Expect = 7e-13
Identities = 137/644 (21%), Positives = 270/644 (41%), Gaps = 89/644 (13%)
Query: 179 IKAGDLRSEHQSHQEAISKIKWESERDIRRLMDEIKAKDRIIFSLEKELETQTGYVQKLQ 238
+K+ + E + +E KIK E + E K K+ LE+++ T LQ
Sbjct: 846 LKSAETEKEMATMKEEFQKIKDELAKS------EAKRKE-----LEEKMVTLLKEKNDLQ 894
Query: 239 LQKEALDEQLFLVKE-------AECNMSSPKREIPGRAGDGSEHCSSPDLRRNQ------ 285
LQ +A E L +E + + + +E+ RA D E + ++ +
Sbjct: 895 LQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS 954
Query: 286 ---KRIAELNATIRKLEDRNTLLGDERNELLKRVRETEKQCKPLLERNKCLAKRNDELMV 342
K I +L T+ K+E ++ L + + ++ L + K L + + + +
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLD 1014
Query: 343 SLQRMEEKLKAVTKENSEMREKITS-HPPLKKLKSLN-DLDQANEEQETEFLKLQVIEQQ 400
LQ E+K+ +TK ++ +++ L++ K L DL++A + E + LKL Q+
Sbjct: 1015 DLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGD-LKL---AQE 1070
Query: 401 NIIDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPAT 460
+I+D + ++++L + K + + ++ DE ++ + R
Sbjct: 1071 SIMD-IENEKQQLDEKLKKKEFEISNLQSKIE-----DEQALGIQLQKKIKELQARIEEL 1124
Query: 461 PDDDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVL 520
++ E + ++E + L++E + + E+ GG A+ E + + + + +
Sbjct: 1125 EEEIEAERASRAKAEKQRSDLSRELEEISERL----EEAGGATSAQIEMNKKREAEFQKM 1180
Query: 521 RYKAKIEDLE-----ATLAQKGQDSHWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQ 575
R + L+ ATL +K DS V + I Q + +K+EK+++E ++ E+
Sbjct: 1181 RRDLEEATLQHEATAATLRKKHADS--VAELGEQIDNLQRVKQKLEKEKSE---MKMEID 1235
Query: 576 DARDQNELLEFRNLELEERERRSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQ 635
D E + LE+ R D +S L+ KE + I DL Q
Sbjct: 1236 DLASNVETVSKAKGNLEKMCR----------TLEDQLSELK---SKEEEQQRLINDLTAQ 1282
Query: 636 LDILGDNGNLRNEEQVAIIQASTVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIK 695
G L+ E + S L E + Q+ + A Q++ EL+ +E+ K K
Sbjct: 1283 ------RGRLQTESG----EFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1332
Query: 696 GYLEEELDYRKQALD---QAYMRIQELEATLYNALQQETV------IKFGELLSEKQQEE 746
L L + D + Y QE +A L AL + K+ E + ++ EE
Sbjct: 1333 NALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY-ETDAIQRTEE 1391
Query: 747 LRTAVEKLRRQMLRKSREYDCQILQERMELLQQAHQRIR-DLED 789
L A +KL +++ ++ E + + + L++ QR++ ++ED
Sbjct: 1392 LEEAKKKLAQRL--QAAEEHVEAVNAKCASLEKTKQRLQNEVED 1433
Score = 59.7 bits (143), Expect = 1e-08
Identities = 125/686 (18%), Positives = 274/686 (39%), Gaps = 115/686 (16%)
Query: 6 RNKGEKPEALIVALQAANEDLRTKLTDIQIELHQEKSKVSKLEREKTQEAKRIRELEQRK 65
++K E+ + LI L A L+T+ + +L ++++ VS+L R K ++I EL+++
Sbjct: 1266 KSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQ- 1324
Query: 66 HTVLVTELKAK-----LHEEKMKELQAVRENLIKQHEQ--EMSRTVKVRDGEIQRLKS-- 116
L E+KAK + + +RE ++ E E+ R + + E+ + ++
Sbjct: 1325 ---LEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY 1381
Query: 117 ---ALCALRDGSSDKVRTALTIEAREEARKLFDTE-------RLKLLQEIADLKTAKKQV 166
A+ + K + A ++A EE + + + + +L E+ DL ++
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERT 1441
Query: 167 DEALSNM------------------------IQADKIKAGDLRSE-------HQSHQEAI 195
+ A + + ++A + +A L +E ++ + +
Sbjct: 1442 NAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQL 1501
Query: 196 SKIKWES---ERDIRRLMDEIKAKDRIIFSLEK---ELETQTGYVQKLQLQKEA-LDEQL 248
+K E+ +++I L ++I + I LEK ++E + +Q + EA L+ +
Sbjct: 1502 ETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEE 1561
Query: 249 FLVKEAECNMSSPKREIPGRAGDGSEHCSSPDLRRNQKRIAE-----LNATIRKLED--- 300
+ + ++ K E+ + + E L+RN RI E L+A IR D
Sbjct: 1562 GKILRIQLELNQVKSEVDRKIAEKDEEIDQ--LKRNHIRIVESMQSTLDAEIRSRNDAIR 1619
Query: 301 -RNTLLGDERN-------------ELLKRVRETEKQCKPLLERNKCLAKRNDELMVSLQR 346
+ + GD E L+ R T+ K + ++L L
Sbjct: 1620 LKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAM 1679
Query: 347 MEEKLKAVTKENSEMREKITSHPPLKKLKSLNDLDQANEEQETEFLKLQVIEQ----QNI 402
+E + + E E+R + +K+ LD + Q +I +
Sbjct: 1680 VERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD 1739
Query: 403 IDELTRDREKLIRRRKHRRSSKPIKRPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPD 462
I ++ + E +++ R + + K+ + D + +E + +TS+
Sbjct: 1740 ISQMQGEMEDILQEA--RNAEEKAKKAITDAAMMAEELKKEQDTSAHL------------ 1785
Query: 463 DDLDESLAAEESELRFRQLTKEYQALQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRY 522
+ + +++ +L+ R E AL+ +Q+ + + E E +++++ AE ++
Sbjct: 1786 ERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKG 1845
Query: 523 KAKIEDLEATLAQKGQDSH--------WVEDKQLFIKRNQELLEKIEKQEAEN----HRL 570
K E L + ++ V+ Q +K + E+ E+Q N +L
Sbjct: 1846 LRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKL 1905
Query: 571 QQELQDARDQNELLEFRNLELEERER 596
Q EL++A ++ ++ E + +L + R
Sbjct: 1906 QHELEEAEERADIAESQVNKLRVKSR 1931
Score = 59.3 bits (142), Expect = 1e-08
Identities = 116/566 (20%), Positives = 235/566 (41%), Gaps = 115/566 (20%)
Query: 313 LKRVRETEKQCKPLLERNKCLAKRNDELMVS---LQRMEEKLKAVTKENSEMREKITSHP 369
L + ETEK+ + E K DEL S + +EEK+ + KE ++++ ++ +
Sbjct: 845 LLKSAETEKEMATMKEE---FQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQA-- 899
Query: 370 PLKKLKSLNDLDQANEEQETEFLKLQVIEQQNI--IDELTRDREKLIRRRKHRRSSKPIK 427
+ + L D EE+ + +K ++ + I + E D E++ + K
Sbjct: 900 ---EAEGLADA----EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAK------K 946
Query: 428 RPVLDPFIGYDEDSMDSETSSMASFRTDRTPATPDDDLDESLAAEESELRFRQLTKEYQA 487
R + D +D D E + + +L E +A + + +LTKE +A
Sbjct: 947 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETI--AKLTKEKKA 1004
Query: 488 LQRAYALLQEQTGGIIDAEREAKAQEQLQAEVLRYKAKIEDLEATLAQKGQ--------- 538
LQ A+ +QT + D + E L ++ + +++DLE +L Q+ +
Sbjct: 1005 LQEAH----QQT--LDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAK 1058
Query: 539 -----DSHWVEDKQLFIK-RNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELE 592
D ++ + I+ Q+L EK++K+E E LQ +++D + L+ + EL+
Sbjct: 1059 RKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQ 1118
Query: 593 ER------------------ERRSPPFNLQIHPFSD------GVSALQIYCMKEGVKDVN 628
R E++ + ++ S+ G ++ QI K+ ++
Sbjct: 1119 ARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKK--REAE 1176
Query: 629 IPDLIKQLDILGDNGNLRNEEQVAIIQASTVLSLAE---------KWIQQIEGAEAALHQ 679
+ + L + L++E A ++ S+AE + Q++E ++ +
Sbjct: 1177 FQKMRRDL----EEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKM 1232
Query: 680 KMMELESDMEQFCKIKG-------YLEEELDYRKQALDQAYMRIQELEATLYNALQQETV 732
++ +L S++E K KG LE++L K ++ I +L A LQ E+
Sbjct: 1233 EIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQ-RGRLQTESG 1291
Query: 733 IKFGELLSEKQ---------QEELRTAVEKLRRQM------------LRKSREYDCQILQ 771
+F L EK+ ++ +E+L+RQ+ +S +DC +L+
Sbjct: 1292 -EFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLR 1350
Query: 772 ERMELLQQAHQRIRDLEDKTDIQKRQ 797
E+ E Q++ ++ K + + Q
Sbjct: 1351 EQYEEEQESKAELQRALSKANTEVAQ 1376
Score = 41.2 bits (95), Expect = 0.004
Identities = 56/279 (20%), Positives = 118/279 (42%), Gaps = 44/279 (15%)
Query: 30 LTDIQIELHQEKSKVSKLEREKTQEAKRIR----ELEQRKHTVLVTELKAKLHEEKMKEL 85
L D QI L L+ + +R E+E+ + T+ TE K+ E+++ +
Sbjct: 1656 LKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA 1715
Query: 86 QAVRENLIKQHEQEMSRTVKVRDGEIQRLKSALCALRD---GSSDKVRTALTIEAR--EE 140
R L+ + T K + +I +++ + + + +K + A+T A EE
Sbjct: 1716 SE-RVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEE 1774
Query: 141 ARKLFDT----ERLK--LLQEIADL------------KTAKKQVDEA------LSNMIQA 176
+K DT ER+K + Q + DL K KKQ+ + L +++
Sbjct: 1775 LKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVES 1834
Query: 177 DKIKAGDLRSEHQSHQEAISKIKWESERD------IRRLMDEIKAK----DRIIFSLEKE 226
++ + + + H+ + ++ +++E D ++ L+D+++AK R E++
Sbjct: 1835 EQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQ 1894
Query: 227 LETQTGYVQKLQLQKEALDEQLFLVKEAECNMSSPKREI 265
T +KLQ + E +E+ + + + RE+
Sbjct: 1895 SNTNLAKFRKLQHELEEAEERADIAESQVNKLRVKSREV 1933
Score = 32.3 bits (72), Expect = 1.8
Identities = 58/278 (20%), Positives = 111/278 (39%), Gaps = 54/278 (19%)
Query: 541 HWVEDKQLFIKRNQELLEKIEKQEAENHRLQQELQDARDQNELLEFRNLELEERE----R 596
HW K F + + LL+ E E E +++E Q +D+ E + ELEE+ +
Sbjct: 832 HWPWMKLFF--KIKPLLKSAET-EKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLK 888
Query: 597 RSPPFNLQIHPFSDGVSALQIYCMKEGVKDVNIPDLIKQLDILGDNGNLRNEEQVAIIQA 656
LQ+ ++G++ + C + + + IK++ +EE++
Sbjct: 889 EKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEV-----TERAEDEEEINA--- 940
Query: 657 STVLSLAEKWIQQIEGAEAALHQKMMELESDMEQFCKIKGYLEEELDYRKQALDQAYMRI 716
++ + L + EL+ D++ +E+E K A + +
Sbjct: 941 ------------ELTAKKRKLEDECSELKKDIDDLELTLAKVEKE----KHATENKVKNL 984
Query: 717 QELEATLYNALQQETVIKFGELLSEKQQEELRTAVEKLRRQMLRKSREYDCQILQERMEL 776
E A L ET+ K L EK+ A+++ +Q L D Q ++++
Sbjct: 985 TEEMAGL-----DETIAK---LTKEKK------ALQEAHQQTLD-----DLQAEEDKVNT 1025
Query: 777 LQQA----HQRIRDLEDKTDIQKRQIKDLEEKSNRKHG 810
L +A Q++ DLE + +K+ DLE + G
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEG 1063
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.340
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,286,871
Number of Sequences: 37866
Number of extensions: 1235402
Number of successful extensions: 15843
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 258
Number of HSP's successfully gapped in prelim test: 1068
Number of HSP's that attempted gapping in prelim test: 6781
Number of HSP's gapped (non-prelim): 5721
length of query: 810
length of database: 18,247,518
effective HSP length: 110
effective length of query: 700
effective length of database: 14,082,258
effective search space: 9857580600
effective search space used: 9857580600
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.