Guide to the Human Genome
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Search of human proteins with 4507921

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507921 WNT1 inducible signaling pathway protein 1 isoform 1
precursor [Homo sapiens]
         (367 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507921 WNT1 inducible signaling pathway protein 1 isoform 1 ...   813   0.0  
gi|18491000 WNT1 inducible signaling pathway protein 1 isoform 2...   361   e-100
gi|4503123 connective tissue growth factor [Homo sapiens]             333   2e-91
gi|38202241 WNT1 inducible signaling pathway protein 3 isoform 3...   329   3e-90
gi|4507925 WNT1 inducible signaling pathway protein 3 isoform 1 ...   329   3e-90
gi|31542331 cysteine-rich, angiogenic inducer, 61 [Homo sapiens]      287   9e-78
gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens]      277   9e-75
gi|4507923 WNT1 inducible signaling pathway protein 2 precursor ...   191   7e-49
gi|37693519 BMP-binding endothelial regulator precursor protein ...    53   4e-07
gi|134031945 SCO-spondin [Homo sapiens]                                51   2e-06
gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]    49   9e-06
gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]    48   1e-05
gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]                47   4e-05
gi|161019170 mucin 5AC [Homo sapiens]                                  43   5e-04
gi|4504619 insulin-like growth factor binding protein 7 [Homo sa...    43   5e-04
gi|169212026 PREDICTED: keratin associated protein [Homo sapiens]      43   5e-04
gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]       43   5e-04
gi|40317626 thrombospondin 1 precursor [Homo sapiens]                  42   7e-04
gi|38490571 keratin associated protein 10-7 [Homo sapiens]             41   0.002
gi|239751787 PREDICTED: hypothetical protein XP_002348012 [Homo ...    40   0.003
gi|169211819 PREDICTED: keratin associated protein [Homo sapiens]      40   0.003
gi|239745811 PREDICTED: hypothetical protein XP_002343557 [Homo ...    40   0.003
gi|154146262 Fc fragment of IgG binding protein [Homo sapiens]         40   0.003
gi|239757284 PREDICTED: similar to Fc fragment of IgG binding pr...    40   0.004
gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens]    40   0.004
gi|4759146 slit homolog 2 [Homo sapiens]                               39   0.006
gi|34147715 chordin-like 1 isoform 3 precursor [Homo sapiens]          39   0.010
gi|221316563 chordin-like 1 isoform 2 precursor [Homo sapiens]         39   0.010
gi|221316561 chordin-like 1 isoform 1 precursor [Homo sapiens]         39   0.010
gi|40353769 chordin-like 2 [Homo sapiens]                              39   0.010

>gi|4507921 WNT1 inducible signaling pathway protein 1 isoform 1
           precursor [Homo sapiens]
          Length = 367

 Score =  813 bits (2099), Expect = 0.0
 Identities = 367/367 (100%), Positives = 367/367 (100%)

Query: 1   MRWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPP 60
           MRWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPP
Sbjct: 1   MRWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPP 60

Query: 61  RCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVG 120
           RCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVG
Sbjct: 61  RCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVG 120

Query: 121 VGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCC 180
           VGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCC
Sbjct: 121 VGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCC 180

Query: 181 EQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISN 240
           EQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISN
Sbjct: 181 EQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISN 240

Query: 241 VNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKY 300
           VNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKY
Sbjct: 241 VNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKY 300

Query: 301 CGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYP 360
           CGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYP
Sbjct: 301 CGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYP 360

Query: 361 DFSEIAN 367
           DFSEIAN
Sbjct: 361 DFSEIAN 367


>gi|18491000 WNT1 inducible signaling pathway protein 1 isoform 2
           precursor [Homo sapiens]
          Length = 280

 Score =  361 bits (926), Expect = e-100
 Identities = 177/236 (75%), Positives = 184/236 (77%), Gaps = 12/236 (5%)

Query: 140 CKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCED--------DAKR 191
           CK+ C C      C PL + +      C       +  +C E  +C+            R
Sbjct: 49  CKWPCECPPSPPRC-PLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDR 107

Query: 192 PRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQES 251
           PR           AVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQES
Sbjct: 108 PRYAIGV---CAHAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQES 164

Query: 252 RLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCI 311
           RLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCI
Sbjct: 165 RLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCI 224

Query: 312 PYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFSEIAN 367
           PYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFSEIAN
Sbjct: 225 PYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFSEIAN 280



 Score =  263 bits (672), Expect = 2e-70
 Identities = 118/120 (98%), Positives = 118/120 (98%)

Query: 1   MRWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPP 60
           MRWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPP
Sbjct: 1   MRWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPP 60

Query: 61  RCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVG 120
           RCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCA  VG
Sbjct: 61  RCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAHAVG 120


>gi|4503123 connective tissue growth factor [Homo sapiens]
          Length = 349

 Score =  333 bits (853), Expect = 2e-91
 Identities = 158/343 (46%), Positives = 210/343 (61%), Gaps = 14/343 (4%)

Query: 23  TALSPAPTTMDFTPAPLEDTSSRP---QFCKWPCECPPSP-PRCPLGVSLITDGCECCKM 78
           TA S  P  + F    L    SRP   Q C  PC CP  P PRCP GVSL+ DGC CC++
Sbjct: 2   TAASMGPVRVAFVV--LLALCSRPAVGQNCSGPCRCPDEPAPRCPAGVSLVLDGCGCCRV 59

Query: 79  CAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQP 138
           CA+QLG+ CTE   CDPH+GL+CD+     R  IGVC    G  C+  G  Y +G+SFQ 
Sbjct: 60  CAKQLGELCTERDPCDPHKGLFCDFGSPANR-KIGVCTAKDGAPCIFGGTVYRSGESFQS 118

Query: 139 NCKYNCTCIDGAVGCTPLC-LRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKR----PR 193
           +CKY CTC+DGAVGC PLC + VR P   CP PRRV +PG CCE+WVC++   +    P 
Sbjct: 119 SCKYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPA 178

Query: 194 KTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRL 253
             A R    F    +      NC+  T+ WS CS +CG+G+STR++N NA C  E++SRL
Sbjct: 179 LAAYRLEDTFGP--DPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRL 236

Query: 254 CNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPY 313
           C +RPC+ D+   IK GKKC+   +    + F L+GC S ++Y+ K+CGVC D RCC P+
Sbjct: 237 CMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPH 296

Query: 314 KSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADL 356
           ++ T+ V F+CPDG    + +++I  C C+ +C   NDIF  L
Sbjct: 297 RTTTLPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESL 339


>gi|38202241 WNT1 inducible signaling pathway protein 3 isoform 3
           [Homo sapiens]
          Length = 372

 Score =  329 bits (843), Expect = 3e-90
 Identities = 150/334 (44%), Positives = 207/334 (61%), Gaps = 10/334 (2%)

Query: 27  PAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDN 86
           P  TT +  P  + D   R QFC WPC+CP   PRCP GVSL+ DGC CCK+CA+Q G+ 
Sbjct: 44  PLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEI 103

Query: 87  CTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTC 146
           C EA +CDPH+GLYCDYS DRPRY  GVCA +V VGC  + V Y+NGQ FQPN  ++C C
Sbjct: 104 CNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLC 163

Query: 147 IDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCE-DDAKRPRKTAPRDTGAFDA 205
           + GA+GCTPL +    P+L   H       G   +Q  C  +   +   T+ +   A+  
Sbjct: 164 VSGAIGCTPLFI----PKLAGSHCSGAK-GGKKSDQSNCSLEPLLQQLSTSYKTMPAYRN 218

Query: 206 VGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHT 265
           +  +  W + C+   + W+PCS +CG+G+S R++N N+ C   +E RLC ++PCD +I  
Sbjct: 219 LPLI--WKKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILK 276

Query: 266 LIK--AGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQ 323
            IK   GK C   +Q   +  F  +GC ST+SY+P +CG+C+D RCCIP KSK I + F 
Sbjct: 277 TIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFD 336

Query: 324 CPDGLGFSRQVLWINACFCNLSCRNPNDIFADLE 357
           CP+   F  ++LWI +C C  +CR P DIF++L+
Sbjct: 337 CPNEGSFKWKMLWITSCVCQRNCREPGDIFSELK 370


>gi|4507925 WNT1 inducible signaling pathway protein 3 isoform 1
           [Homo sapiens]
          Length = 354

 Score =  329 bits (843), Expect = 3e-90
 Identities = 150/334 (44%), Positives = 207/334 (61%), Gaps = 10/334 (2%)

Query: 27  PAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDN 86
           P  TT +  P  + D   R QFC WPC+CP   PRCP GVSL+ DGC CCK+CA+Q G+ 
Sbjct: 26  PLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEI 85

Query: 87  CTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTC 146
           C EA +CDPH+GLYCDYS DRPRY  GVCA +V VGC  + V Y+NGQ FQPN  ++C C
Sbjct: 86  CNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLC 145

Query: 147 IDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCE-DDAKRPRKTAPRDTGAFDA 205
           + GA+GCTPL +    P+L   H       G   +Q  C  +   +   T+ +   A+  
Sbjct: 146 VSGAIGCTPLFI----PKLAGSHCSGAK-GGKKSDQSNCSLEPLLQQLSTSYKTMPAYRN 200

Query: 206 VGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHT 265
           +  +  W + C+   + W+PCS +CG+G+S R++N N+ C   +E RLC ++PCD +I  
Sbjct: 201 LPLI--WKKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILK 258

Query: 266 LIK--AGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQ 323
            IK   GK C   +Q   +  F  +GC ST+SY+P +CG+C+D RCCIP KSK I + F 
Sbjct: 259 TIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFD 318

Query: 324 CPDGLGFSRQVLWINACFCNLSCRNPNDIFADLE 357
           CP+   F  ++LWI +C C  +CR P DIF++L+
Sbjct: 319 CPNEGSFKWKMLWITSCVCQRNCREPGDIFSELK 352


>gi|31542331 cysteine-rich, angiogenic inducer, 61 [Homo sapiens]
          Length = 381

 Score =  287 bits (735), Expect = 9e-78
 Identities = 149/389 (38%), Positives = 210/389 (53%), Gaps = 54/389 (13%)

Query: 18  STVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCK 77
           S+ +A AL+   T +  T   L         C   C CP   P+C  GV L+ DGC CCK
Sbjct: 2   SSRIARALALVVTLLHLTRLALST-------CPAACHCPLEAPKCAPGVGLVRDGCGCCK 54

Query: 78  MCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVC-AQVVGVGCVLDGVRYNNGQSF 136
           +CA+QL ++C++   CD  +GL C++ G       G+C AQ  G  C  +   Y NG+SF
Sbjct: 55  VCAKQLNEDCSKTQPCDHTKGLECNF-GASSTALKGICRAQSEGRPCEYNSRIYQNGESF 113

Query: 137 QPNCKYNCTCIDGAVGCTPLC-LRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDA-KRPRK 194
           QPNCK+ CTCIDGAVGC PLC   +  P L CP+PR V + G CCE+WVC++D+ K P +
Sbjct: 114 QPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPME 173

Query: 195 TAPRDTG---AFDAVGEVEAWHRN--------------------------------CIAY 219
                 G    FDA  EVE    N                                CI  
Sbjct: 174 DQDGLLGKELGFDA-SEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQ 232

Query: 220 TSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQP 279
           T+ WS CS +CG G+STR++N N +C   +E+R+C +RPC   +++ +K GKKC    + 
Sbjct: 233 TTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKS 292

Query: 280 EASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINA 339
              + FT AGC+S + Y+PKYCG C+D RCC P  ++T+ + F+C DG  FS+ V+ I +
Sbjct: 293 PEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQS 352

Query: 340 CFCNLSCRNPND-------IFADLESYPD 361
           C CN +C + N+       +F D+  + D
Sbjct: 353 CKCNYNCPHANEAAFPFYRLFNDIHKFRD 381


>gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens]
          Length = 357

 Score =  277 bits (709), Expect = 9e-75
 Identities = 132/307 (42%), Positives = 178/307 (57%), Gaps = 7/307 (2%)

Query: 52  PCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYA 111
           P  CP +PP C  GV  + DGC CC +CA+Q G++C++   CD   GLYCD S D P   
Sbjct: 40  PGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSAD-PSNQ 98

Query: 112 IGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLC-LRVRPPRLWCPHP 170
            G+C  V G  CV DGV Y +G+ FQP+CK+ CTC DG +GC P C L V  P   CP P
Sbjct: 99  TGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAP 158

Query: 171 RRVSIPGHCCEQWVC---EDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCS 227
           R+V +PG CCE+W+C   E+D+      A     A   V EV     NCI  T+ W+ CS
Sbjct: 159 RKVEVPGECCEKWICGPDEEDSLGGLTLAAYRPEATLGV-EVSDSSVNCIEQTTEWTACS 217

Query: 228 TSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLI-KAGKKCLAVYQPEASMNFT 286
            SCG+G STR++N N QC   +++RLC +RPC+ +      K GKKCL   +   +++  
Sbjct: 218 KSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQ 277

Query: 287 LAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSC 346
              C S  +Y+P++CGVC D RCC P+ +KTI   FQC  G    + V+ I  C C+ +C
Sbjct: 278 FKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHTNC 337

Query: 347 RNPNDIF 353
              N+ F
Sbjct: 338 PKNNEAF 344


>gi|4507923 WNT1 inducible signaling pathway protein 2 precursor
           [Homo sapiens]
          Length = 250

 Score =  191 bits (486), Expect = 7e-49
 Identities = 92/217 (42%), Positives = 122/217 (56%), Gaps = 3/217 (1%)

Query: 45  RPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCD-Y 103
           R Q C  PC CP  PPRCPLGV L+ DGC CC++CA++LG+ C +  +CD  +GL C   
Sbjct: 22  RTQLCPTPCTCPWPPPRCPLGVPLVLDGCGCCRVCARRLGEPCDQLHVCDASQGLVCQPG 81

Query: 104 SGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLR-VRP 162
           +G   R A+ + A+     C ++G  Y  G++FQP+C   C C DG   C PLC   VR 
Sbjct: 82  AGPGGRGALCLLAE-DDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRL 140

Query: 163 PRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSP 222
           P   CPHPRRV + G CC +WVC        +  P     F  +         C  +++ 
Sbjct: 141 PSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTA 200

Query: 223 WSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPC 259
           W PCST+CGLG++TR+SN N  C  E + RLC  RPC
Sbjct: 201 WGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPC 237


>gi|37693519 BMP-binding endothelial regulator precursor protein
           [Homo sapiens]
          Length = 685

 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 74/306 (24%), Positives = 105/306 (34%), Gaps = 63/306 (20%)

Query: 54  ECPPSPPRCPLGVSLITDGCECCKMCAQQLGD-----------------NCTEAAICDPH 96
           +CP     C L +      CE CK C  +                     C E  + +  
Sbjct: 83  KCPVLSRDCALAIKQRGACCEQCKGCTYEGNTYNSSFKWQSPAEPCVLRQCQEGVVTES- 141

Query: 97  RGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCK--YNCTCIDGAVGCT 154
            G+ C      P   +G+C      GCV +GV+Y  G+ FQP       C+C  G     
Sbjct: 142 -GVRCVVHCKNPLEHLGMCCPTCP-GCVFEGVQYQEGEEFQPEGSKCTKCSCTGGRT--- 196

Query: 155 PLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEV----- 209
             C+R   P L CP       PG CC + + +      RK      G+     +V     
Sbjct: 197 -QCVREVCPILSCPQHLSHIPPGQCCPKCLGQ------RKVFDLPFGSCLFRSDVYDNGS 249

Query: 210 EAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQES--RLCNLRPCDVDIHTLI 267
              + NC A       C+      V  R  +    C   QE     C LR    DI  + 
Sbjct: 250 SFLYDNCTA-------CTCRDSTVVCKRKCSHPGGCDQGQEGCCEECLLRVPPEDI-KVC 301

Query: 268 KAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDG 327
           K G K     +  +S+N T+  C+  R+           N+ CIP  S        CP G
Sbjct: 302 KFGNKIFQDGEMWSSINCTICACVKGRTE--------CRNKQCIPISS--------CPQG 345

Query: 328 LGFSRQ 333
              +R+
Sbjct: 346 KILNRK 351


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 76/340 (22%), Positives = 111/340 (32%), Gaps = 80/340 (23%)

Query: 2    RWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPR 61
            RW  PW+    +     ++ + + S  P+     P   E   +R       C   P    
Sbjct: 4009 RWS-PWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARL------CNPMPCEAG 4061

Query: 62   CPLGVSLITDGCECCKMCAQ-QLGDNCTEAAICDPHRGLYCDYSGDRPRYAI---GVCAQ 117
            CP G+ ++T    C + C+  Q G  C +  +C   +G  C      P+ ++   G C  
Sbjct: 4062 CPAGMEVVTCANRCPRRCSDLQEGIVCQDDQVCQ--KGCRC------PKGSLEQDGGCVP 4113

Query: 118  VVGVGCV-LDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIP 176
            +    C    G  +  G   Q  C  NC+C  G + CT      +P    CP P      
Sbjct: 4114 IGHCDCTDAQGHSWAPGSQHQDACN-NCSCQAGQLSCT-----AQP----CPPPT----- 4158

Query: 177  GHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCG-LGVS 235
             HC                               AW     ++ S WSPCS SCG  G  
Sbjct: 4159 -HC-------------------------------AW-----SHWSAWSPCSHSCGPRGQQ 4181

Query: 236  TRISNVNAQCW-PEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTR 294
            +R  +  +  W PE        +PC             CL   +     +  L G     
Sbjct: 4182 SRFRSSTSGSWAPECREEQSQSQPCPQP-----SCPPLCLQGTRSRTLGDSWLQGECQRC 4236

Query: 295  SYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQV 334
            S  P+   +C D  C +P           CP   G   QV
Sbjct: 4237 SCTPEGV-ICEDTECAVPEAWTLWSSWSDCPVSCGGGNQV 4275



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 75/299 (25%), Positives = 106/299 (35%), Gaps = 44/299 (14%)

Query: 37   APLEDTSSRPQFCKWPCECPPSPPRCPLGVSLIT------DGCECCKMCAQQ-LGDNCTE 89
            AP + T   P      C   P   +CP  +   +      +G  C ++C  Q  G  CT 
Sbjct: 2861 APGDTTCPGPHSQTRDCNTQPCTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTG 2920

Query: 90   --AAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCI 147
              A  C    GL+   +   PR     C       C L G  Y +G   + +   NCTC+
Sbjct: 2921 FCAPGCTCPPGLFLHNASCLPR---SQCP------CQLHGQLYASGAMARLDSCNNCTCV 2971

Query: 148  DGAVGCT----PLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAF 203
             G + CT    P+     P  LW       S+    C   +      R     P   G  
Sbjct: 2972 SGKMACTSERCPVACGWSPWTLW-------SLCSCSCNVGIRR--RFRAGTAPPAAFGGA 3022

Query: 204  DAVG-EVEAWH---RNCI---AYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNL 256
            +  G  +EA     R C        PWSPCS  CG G   R    +       E   C L
Sbjct: 3023 ECQGPTMEAEFCSLRPCPGPGGEWGPWSPCSVPCGGGYRNRTRGSSRSL---MEFSTCGL 3079

Query: 257  RPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPK-YC--GVCMDNRCCIP 312
            +PC   +  +    K+ L   Q  AS     A   + ++  P  +C  G+ + N  C+P
Sbjct: 3080 QPCAGPVPGMCPRDKQWLDCAQGPASCAELSAPRGTNQTCHPGCHCPSGMLLLNNVCVP 3138



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 59/220 (26%), Positives = 78/220 (35%), Gaps = 38/220 (17%)

Query: 36   PAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCE---CCKMCAQQLGDNCTEAAI 92
            P  L D    P+     C+  P    CP+      +G E   C   C +   D       
Sbjct: 3284 PQGLGDYCEGPRAQGEVCQALP----CPVTNCTAIEGAEYSPCGPPCPRSCDDLVHCVWR 3339

Query: 93   CDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCV--LDGVRYNNGQSF-QPNCKYNCTCIDG 149
            C P  G YC   G        +C Q     C+  L G R++ G    +P+   +CTC++G
Sbjct: 3340 CQP--GCYCP-PGQVLSSNGAICVQPGHCSCLDLLTGQRHHPGARLARPDGCNHCTCLEG 3396

Query: 150  AVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTA---PRDTGA--FD 204
             + CT L   V  P  WCP           C Q        R R  A   P+  GA    
Sbjct: 3397 RLNCTDLPCPV--PGGWCPWSEWT-----MCSQPCRGQTRSRSRACACPTPQHGGAPCTG 3449

Query: 205  AVGEVEAWHRN--CIAYTS-----------PWSPCSTSCG 231
              GE  A H+   C +Y +           PWSPC    G
Sbjct: 3450 EAGEAGAQHQREACPSYATCPVDGAWGPWGPWSPCDMCLG 3489



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 53/252 (21%), Positives = 81/252 (32%), Gaps = 71/252 (28%)

Query: 139  NCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPR 198
            +C  +C    G  G        R     CP P   S PG   ++  C      P    P 
Sbjct: 2783 SCSQSCLAPGGGPGW-------RSRSRLCPSPGDSSCPGDATQEEPCSP----PVCPVPS 2831

Query: 199  DTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTR------ISNVNAQC-WPEQES 251
              G +                 +PWS CS  C  G+ TR      ++  +  C  P  ++
Sbjct: 2832 IWGLW-----------------APWSTCSAPCDGGIQTRGRSCSSLAPGDTTCPGPHSQT 2874

Query: 252  RLCNLRPCDVDI--HTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYC----GVCM 305
            R CN +PC      + L ++ ++C     P   +  T    I    +    C    G+ +
Sbjct: 2875 RDCNTQPCTAQCPENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPGLFL 2934

Query: 306  DNRCCIP-----------------------------YKSKTIDVSFQCPDGLGFSRQVLW 336
             N  C+P                                K    S +CP   G+S   LW
Sbjct: 2935 HNASCLPRSQCPCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCPVACGWSPWTLW 2994

Query: 337  -INACFCNLSCR 347
             + +C CN+  R
Sbjct: 2995 SLCSCSCNVGIR 3006



 Score = 37.7 bits (86), Expect = 0.016
 Identities = 24/59 (40%), Positives = 28/59 (47%), Gaps = 13/59 (22%)

Query: 215  NCIAYTS--PWSPCSTSCGLGVSTRI-----SNVNAQCWPE-----QESRLCNLRPCDV 261
            NC ++TS  PW PCS SCG+G   R+             P      QE R CNLR C V
Sbjct: 3946 NC-SWTSWAPWEPCSRSCGVGQQRRLRAYRPPGPGGHWCPNILTAYQERRFCNLRACPV 4003



 Score = 37.0 bits (84), Expect = 0.028
 Identities = 70/262 (26%), Positives = 86/262 (32%), Gaps = 71/262 (27%)

Query: 22   ATALSPAPTTMDFTPAPLEDTSSRP-----QFCKWPCECPPSPPRCPLGVSLITDGCECC 76
            +T   P+P ++D   +PL   S  P     +F     EC P   RC        D  E C
Sbjct: 1539 STLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRC--------DQEEDC 1590

Query: 77   KMCAQQLGDNCTEAAICDPH-----RGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYN 131
               + + G  C     C PH     RG +C                 V    + DGVR  
Sbjct: 1591 ADGSDERG--C--GGPCAPHHAPCARGPHC-----------------VSPEQLCDGVRQC 1629

Query: 132  NGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCE-QWVCED--D 188
               S +           G   C  L     P R   P P      G C   Q VC+   D
Sbjct: 1630 PDGSDE-----------GPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCDGQPD 1678

Query: 189  AKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSC---GLGVSTRISN----V 241
              RP +  P         G    W        SPW PCS +C   G G S R S     V
Sbjct: 1679 CGRPGQVGPSPEE--QGCGAWGPW--------SPWGPCSRTCGPWGQGRSRRCSPLGLLV 1728

Query: 242  NAQC-WPEQESRLCNLRPCDVD 262
               C  PE +S+ C    C VD
Sbjct: 1729 LQNCPGPEHQSQACFTAACPVD 1750



 Score = 36.6 bits (83), Expect = 0.037
 Identities = 61/249 (24%), Positives = 82/249 (32%), Gaps = 40/249 (16%)

Query: 52   PCECPPSPPRCPLGVSLI--TDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPR 109
            PC   P P  CP     +    G   C   +   G N T    C P  G +C  SG    
Sbjct: 3081 PC-AGPVPGMCPRDKQWLDCAQGPASCAELSAPRGTNQT----CHP--GCHCP-SG--ML 3130

Query: 110  YAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVG-CTPL-CLRVRPP-RLW 166
                VC       C  +G  Y  G +    C+ NC+C+ G +  C+   C    P    W
Sbjct: 3131 LLNNVCVPTQDCPCAHEGHLYPPGSTVVRPCE-NCSCVSGLIANCSSWPCAEGEPTWSPW 3189

Query: 167  CPHPRRVSI--PGHCCEQWVC-EDDAKRPRKTAPRDTGAFDA--VGEVEAWHRNCIAYT- 220
             P  +  +   P  C     C    +  P   AP    A         EA    C+    
Sbjct: 3190 TPWSQCSASCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEEPCLLQGC 3249

Query: 221  ---------SPWSPCSTSCGLGVSTRI--------SNVNAQC-WPEQESRLCNLRPCDVD 262
                      PWS CS SCG G+ +R           +   C  P  +  +C   PC V 
Sbjct: 3250 DRAGGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVCQALPCPVT 3309

Query: 263  IHTLIKAGK 271
              T I+  +
Sbjct: 3310 NCTAIEGAE 3318



 Score = 33.1 bits (74), Expect = 0.41
 Identities = 49/229 (21%), Positives = 69/229 (30%), Gaps = 31/229 (13%)

Query: 41   DTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLY 100
            D  + P  C+W    P SP + P          E   +C    G  C E    +   G  
Sbjct: 4608 DPGACPDSCQWSLWGPWSPCQVPCSGGFRLRWREAEALC----GGGCREPWAQESCNGGP 4663

Query: 101  CDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRV 160
            C     +       CA      C      ++  Q  Q  C+  C C  G +     C+ +
Sbjct: 4664 CPECEAQDTVFTLDCANQCPHSCA---DLWDRVQCLQGPCRPGCRCPPGQLVQDGRCVPI 4720

Query: 161  RPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGE-VEAWHRNC--I 217
               R   P              W        P +    D      V E +   H+ C  +
Sbjct: 4721 SSCRCGLPSANA---------SWELA-----PAQAVQLDCQNCTCVNESLVCPHQECPVL 4766

Query: 218  AYTSPWSPCSTSCGLGVSTRISNVN-------AQCWPEQESRLCNLRPC 259
               S WS CS  CG G   R             Q    ++ + CNL+PC
Sbjct: 4767 GPWSAWSSCSAPCGGGTMERHRTCEGGPGVAPCQAQDTEQRQECNLQPC 4815



 Score = 31.2 bits (69), Expect = 1.5
 Identities = 58/259 (22%), Positives = 79/259 (30%), Gaps = 85/259 (32%)

Query: 24   ALSPAPTTMDFTPAPLEDTSSRP--------QFCKWPCECPPSPPRCPLGVSLITDGCEC 75
            A S  PT     P P   T SRP          C       P    CP     ++ G  C
Sbjct: 3496 ACSRPPTPEGGRPCPGNHTQSRPCQENSTQCTDCGGGQSLHPCGQPCPRSCQDLSPGSVC 3555

Query: 76   ------CK-MCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGV 128
                  C+  C   LG   ++  +C P     C Y       A+G+            G 
Sbjct: 3556 QPGSVGCQPTCGCPLGQ-LSQDGLCVPPAHCRCQYQPG----AMGIPENQSRSA----GS 3606

Query: 129  RYNNGQSFQPN------CKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQ 182
            R+++ +S +P       C  NCTC+ G + C  +     P    CP P            
Sbjct: 3607 RFSSWESLEPGEVVTGPCD-NCTCVAGILQCQEV-----PD---CPDP------------ 3645

Query: 183  WVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISN-V 241
                                    G   +W         PW  CS SCG G   R     
Sbjct: 3646 ------------------------GVWSSW--------GPWEDCSVSCGGGEQLRSRRCA 3673

Query: 242  NAQC-WPEQESRLCNLRPC 259
               C  P ++SR C+ + C
Sbjct: 3674 RPPCPGPARQSRTCSTQVC 3692



 Score = 30.8 bits (68), Expect = 2.0
 Identities = 18/46 (39%), Positives = 20/46 (43%), Gaps = 9/46 (19%)

Query: 223  WSPCSTSCGLGVSTR--------ISNVNAQC-WPEQESRLCNLRPC 259
            W PCS SCG G  +R          N  A C    QE   C L+PC
Sbjct: 2564 WGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPCGLQPC 2609



 Score = 30.8 bits (68), Expect = 2.0
 Identities = 17/36 (47%), Positives = 18/36 (50%), Gaps = 9/36 (25%)

Query: 203  FDAVGEVEAWHRNCIAYTSPWSPCSTSC-GLGVSTR 237
            F+A G    W        SPW PCS SC GLG  TR
Sbjct: 3808 FEADGGFGPW--------SPWGPCSRSCGGLGTRTR 3835



 Score = 30.8 bits (68), Expect = 2.0
 Identities = 13/34 (38%), Positives = 19/34 (55%), Gaps = 2/34 (5%)

Query: 222  PWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCN 255
            PW PCS SCG G+++R  + +  C   +    CN
Sbjct: 4315 PWGPCSRSCGPGLASR--SGSCPCLMAKADPTCN 4346



 Score = 30.4 bits (67), Expect = 2.6
 Identities = 34/141 (24%), Positives = 49/141 (34%), Gaps = 35/141 (24%)

Query: 123  CVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPP-------RLWCPHPRRVSI 175
            C++DG RY  GQ  + +C+  C C DG     P   R+ P          W P  + +  
Sbjct: 1870 CLVDGARYWPGQRIKADCQL-CICQDG----RPRRCRLNPDCAVDCGWSSWSPWAKCLGP 1924

Query: 176  PGHCCEQW---------------VCEDDAKRPRKTAPRDTGAFDAVGEV----EAWH--- 213
             G    QW                C    ++ R+         +  G+V    E WH   
Sbjct: 1925 CGSQSIQWSFRSSNNPRPSGRGRQCRGIHRKARRCQTEPCEGCEHQGQVHRVGERWHGGP 1984

Query: 214  -RNCIAYTSPWSPCSTSCGLG 233
             R C    +  + CS  C LG
Sbjct: 1985 CRVCQCLHNLTAHCSPYCPLG 2005


>gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]
          Length = 1503

 Score = 48.5 bits (114), Expect = 9e-06
 Identities = 52/176 (29%), Positives = 63/176 (35%), Gaps = 27/176 (15%)

Query: 42  TSSRPQFCKWPCECPPSPPRCPLGVSLITDG------CECCKMCAQQLGDNCTEAAICDP 95
           T +RPQ    P +C P  P C L   +  DG       + C+ C  Q G      A C P
Sbjct: 466 TCARPQ--SGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGH-----AHCQP 518

Query: 96  HRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSF---QPNCKYNCTCIDGAVG 152
                   +   P    G C      GC   G  Y +G  F      C+  C C+ G V 
Sbjct: 519 RPCPRAPCAHPLP----GTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRL-CRCLSGNVQ 573

Query: 153 CTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGE 208
           C  L  R  P  L CP P  V +PG CC Q        RP     R    F   G+
Sbjct: 574 C--LARRCVP--LPCPEP--VLLPGECCPQCPAPAGCPRPGAAHARHQEYFSPPGD 623



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 39/137 (28%), Positives = 49/137 (35%), Gaps = 43/137 (31%)

Query: 53  CECPPSPPRC-------PLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGL-YCDYS 104
           CEC P+ P+C       P G     D C  C +C          AA C P   L +C   
Sbjct: 87  CECHPASPQCWGLGRAWPEGARWEPDACTAC-VCQDG-------AAHCGPQAHLPHCR-- 136

Query: 105 GDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCT-PLCLRVRPP 163
                            GC  +G  Y NG++F P+    C C+ GAV C  P C  +   
Sbjct: 137 -----------------GCSQNGQTYGNGETFSPDACTTCRCLTGAVQCQGPSCSELNCL 179

Query: 164 RLWCPHPRRVSIPGHCC 180
               P       PG CC
Sbjct: 180 ESCTP-------PGECC 189



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 47/182 (25%), Positives = 68/182 (37%), Gaps = 42/182 (23%)

Query: 74  ECCKMCAQQLGDN------------------CTEAAICDPHR--GLYCDYSGDRPRYAIG 113
           ECC +C  + G +                  C E  I    R     C Y     R   G
Sbjct: 187 ECCPICCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYPA---RPLPG 243

Query: 114 VCAQVVGVGCVLDGVRYNNGQSFQPN--CKYNCTCIDGAVGCTPL-CLRVRPPRLWCPHP 170
            C  V   GC L+G  + +G+       C + C C +G+V C PL C     P + C HP
Sbjct: 244 TCCPVCD-GCFLNGREHRSGEPVGSGDPCSH-CRCANGSVQCEPLPC-----PPVPCRHP 296

Query: 171 RRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVG-----EVEAWHRNCIAYTSPWSP 225
            +  IPG CC   VC+    +  +   ++T      G       +A   +C     P +P
Sbjct: 297 GK--IPGQCCP--VCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTP 352

Query: 226 CS 227
           C+
Sbjct: 353 CA 354



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 53/237 (22%), Positives = 74/237 (31%), Gaps = 56/237 (23%)

Query: 49  CKWPCECPP------------SPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPH 96
           C  P  CP             SPP  P    L  DG   C+         C  A    P 
Sbjct: 598 CPAPAGCPRPGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQRLP------CPPAPCAHPR 651

Query: 97  RGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSF-QPNCKYN-CTCIDGAVGCT 154
           +G  C                    GC+  G  + +G+ F  P    + C C +G+V C 
Sbjct: 652 QGPCCPSCD----------------GCLYQGKEFASGERFPSPTAACHLCLCWEGSVSCE 695

Query: 155 PLCLRVRPPRLWCPHPRRVSIPGHCC----------EQWVCEDDAKRPRKTAPRDT--GA 202
           P   +   P L CP P R    G CC          E ++   +   PR+     T  G 
Sbjct: 696 P---KACAPAL-CPFPAR----GDCCPDCDGCEYLGESYLSNQEFPDPREPCNLCTCLGG 747

Query: 203 FDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPC 259
           F   G        C     P   C  +C       ++  + +  P+     C+L  C
Sbjct: 748 FVTCGRRPCEPPGCSHPLIPSGHCCPTCQGCRYHGVTTASGETLPDPLDPTCSLCTC 804



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 39/153 (25%), Positives = 52/153 (33%), Gaps = 42/153 (27%)

Query: 52  PCECPPSPPRCPLGVS----LITDGCE------------------CCKMCAQQLGDNCTE 89
           P  CPP P R P  +      + DGCE                   C  C+ Q G+   E
Sbjct: 285 PLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCE 344

Query: 90  AAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCK--YNCTCI 147
              C                 A+    + +   C LDG  +  G  ++P+ +    C C 
Sbjct: 345 EQECPV------------TPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQ 392

Query: 148 DGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCC 180
           DG     P C  V  P   C HP +   PG CC
Sbjct: 393 DG----VPKCGAVLCPPAPCQHPTQP--PGACC 419



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 46/154 (29%), Positives = 60/154 (38%), Gaps = 37/154 (24%)

Query: 54   ECPPSPPRCPLGVSLITDGCECCKMCAQQLG--------------DNCTEAAICDPHRG- 98
            +CPP P  C L V   T+   CC  C   L               D+   + +C  H G 
Sbjct: 873  QCPPLP--CKLQV---TERGSCCPRCRGCLAHGEEHPEGSRWVPPDSACSSCVC--HEGV 925

Query: 99   -----LYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPN---CKYNCTCIDGA 150
                 + C  S  +PR     C       C  +G +Y  G+SFQP    C+  C C    
Sbjct: 926  VTCARIQCISSCAQPRQGPHDCCPQCS-DCEHEGRKYEPGESFQPGADPCEV-CICEPQP 983

Query: 151  VGCTPL-CLRVRPPRL-WCPHPRRVSIPG--HCC 180
             G   L C R + P L  CP P ++  PG  HCC
Sbjct: 984  EGPPSLRCHRRQCPSLVGCP-PSQLLPPGPQHCC 1016



 Score = 33.1 bits (74), Expect = 0.41
 Identities = 39/149 (26%), Positives = 51/149 (34%), Gaps = 30/149 (20%)

Query: 52  PCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGD----- 106
           P  CP +P   PL  +   + C  C    ++           DP R   C  SG+     
Sbjct: 518 PRPCPRAPCAHPLPGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRC-LSGNVQCLA 576

Query: 107 ---------RPRYAIGVCAQV--VGVGCVLDGVRYNNGQS-FQPN---CKYNCTCIDGAV 151
                     P    G C        GC   G  +   Q  F P    C+  C C+DG+V
Sbjct: 577 RRCVPLPCPEPVLLPGECCPQCPAPAGCPRPGAAHARHQEYFSPPGDPCR-RCLCLDGSV 635

Query: 152 GCTPLCLRVRPPRLWCPHPRRVSIPGHCC 180
            C     R+  P   C HPR+    G CC
Sbjct: 636 SCQ----RLPCPPAPCAHPRQ----GPCC 656



 Score = 32.7 bits (73), Expect = 0.53
 Identities = 17/43 (39%), Positives = 20/43 (46%), Gaps = 4/43 (9%)

Query: 138  PNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCC 180
            P+  Y C C D     T LC+    P L CP   R + PG CC
Sbjct: 1038 PDPCYTCQCQD----LTWLCIHQACPELSCPLSERHTPPGSCC 1076


>gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]
          Length = 814

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 39/137 (28%), Positives = 51/137 (37%), Gaps = 47/137 (34%)

Query: 53  CECPPSPPRC-------PLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGL-YCDYS 104
           CEC P+ P+C       P G     D C  C +C          AA C P   L +C   
Sbjct: 87  CECHPASPQCWGLGRAWPEGARWEPDACTAC-VCQDG-------AAHCGPQAHLPHCR-- 136

Query: 105 GDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRP-P 163
                            GC  +G  Y NG++F P+    C C++G + C       +P P
Sbjct: 137 -----------------GCSQNGQTYGNGETFSPDACTTCRCLEGTITCNQ-----KPCP 174

Query: 164 RLWCPHPRRVSIPGHCC 180
           R  CP       PG CC
Sbjct: 175 RGPCPE------PGACC 185



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 53/198 (26%), Positives = 76/198 (38%), Gaps = 37/198 (18%)

Query: 54  ECPPSPPRCPLGVSLITDGCECCKMCAQ------------QLGDNCTEAAICDPH---RG 98
           +CPPSP  CP  V      C  C+ C +              GD C      + H   R 
Sbjct: 228 KCPPSP--CPEPVLRPGHCCPTCQGCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQ 285

Query: 99  LYCDYSGDRPRYAI-GVCAQVVGVGCVLDGVRYNNGQSFQPN--CKYNCTCIDGAVGCTP 155
             C      P   + G C  V   GC L+G  + +G+       C + C C +G+V C P
Sbjct: 286 RECASLCPYPARPLPGTCCPVCD-GCFLNGREHRSGEPVGSGDPCSH-CRCANGSVQCEP 343

Query: 156 L-CLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVG-----EV 209
           L C     P + C HP +  IPG CC   VC+    +  +   ++T      G       
Sbjct: 344 LPC-----PPVPCRHPGK--IPGQCCP--VCDGCEYQGHQYQSQETFRLQERGLCVRCSC 394

Query: 210 EAWHRNCIAYTSPWSPCS 227
           +A   +C     P +PC+
Sbjct: 395 QAGEVSCEEQECPVTPCA 412



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 47/150 (31%), Positives = 57/150 (38%), Gaps = 27/150 (18%)

Query: 42  TSSRPQFCKWPCECPPSPPRCPLGVSLITDG------CECCKMCAQQLGDNCTEAAICDP 95
           T +RPQ    P +C P  P C L   +  DG       + C+ C  Q G      A C P
Sbjct: 524 TCARPQ--SGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGH-----AHCQP 576

Query: 96  HRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSF---QPNCKYNCTCIDGAVG 152
                   +   P    G C      GC   G  Y +G  F      C+  C C+ G V 
Sbjct: 577 RPCPRAPCAHPLP----GTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRL-CRCLSGNVQ 631

Query: 153 CTPLCLRVRPPRLWCPHPRRVSIPGHCCEQ 182
           C  L  R  P  L CP P  V +PG CC Q
Sbjct: 632 C--LARRCVP--LPCPEP--VLLPGECCPQ 655



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 33/126 (26%), Positives = 42/126 (33%), Gaps = 38/126 (30%)

Query: 65  GVSLITDGCECCKMCAQQLGDN--------CTEAAICDPHRGLYCDYSGDRPRYAIGVCA 116
           G +   D C  C+     +  N        C E   C PH    CDY             
Sbjct: 148 GETFSPDACTTCRCLEGTITCNQKPCPRGPCPEPGACCPHCKPGCDY------------- 194

Query: 117 QVVGVGCVLDGVRYNNGQSF--QPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVS 174
                    +G  Y  G +F    N    CTC+   V     C+ ++ P   CP P  V 
Sbjct: 195 ---------EGQLYEEGVTFLSSSNPCLQCTCLRSRV----RCMALKCPPSPCPEP--VL 239

Query: 175 IPGHCC 180
            PGHCC
Sbjct: 240 RPGHCC 245



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 39/153 (25%), Positives = 52/153 (33%), Gaps = 42/153 (27%)

Query: 52  PCECPPSPPRCPLGVS----LITDGCE------------------CCKMCAQQLGDNCTE 89
           P  CPP P R P  +      + DGCE                   C  C+ Q G+   E
Sbjct: 343 PLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCE 402

Query: 90  AAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCK--YNCTCI 147
              C                 A+    + +   C LDG  +  G  ++P+ +    C C 
Sbjct: 403 EQECPV------------TPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQ 450

Query: 148 DGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCC 180
           DG     P C  V  P   C HP +   PG CC
Sbjct: 451 DG----VPKCGAVLCPPAPCQHPTQP--PGACC 477



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 41/162 (25%), Positives = 54/162 (33%), Gaps = 43/162 (26%)

Query: 36  PAPLEDTSSRPQFCKWPCECPPSPPRCPLG----------VSLITDGCECC-----KMCA 80
           P P  +    P  C   C   P+P  CP             S   D C  C      +  
Sbjct: 639 PLPCPEPVLLPGECCPQCPAAPAPAGCPRPGAAHARHQEYFSPPGDPCRRCLCLDGSVSC 698

Query: 81  QQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSF-QPN 139
           Q+L   C  A    P +G  C                    GC+  G  + +G+ F  P 
Sbjct: 699 QRL--PCPPAPCAHPRQGPCCPSCD----------------GCLYQGKEFASGERFPSPT 740

Query: 140 CK-YNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCC 180
              + C C +G+V C P   +   P L CP P R    G CC
Sbjct: 741 AACHLCLCWEGSVSCEP---KACAPAL-CPFPAR----GDCC 774



 Score = 33.5 bits (75), Expect = 0.31
 Identities = 40/152 (26%), Positives = 52/152 (34%), Gaps = 33/152 (21%)

Query: 52  PCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGD----- 106
           P  CP +P   PL  +   + C  C    ++           DP R   C  SG+     
Sbjct: 576 PRPCPRAPCAHPLPGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRC-LSGNVQCLA 634

Query: 107 ---------RPRYAIGVC-----AQVVGVGCVLDGVRYNNGQS-FQPN---CKYNCTCID 148
                     P    G C     A     GC   G  +   Q  F P    C+  C C+D
Sbjct: 635 RRCVPLPCPEPVLLPGECCPQCPAAPAPAGCPRPGAAHARHQEYFSPPGDPCR-RCLCLD 693

Query: 149 GAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCC 180
           G+V C     R+  P   C HPR+    G CC
Sbjct: 694 GSVSCQ----RLPCPPAPCAHPRQ----GPCC 717


>gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]
          Length = 1036

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 45/166 (27%), Positives = 66/166 (39%), Gaps = 40/166 (24%)

Query: 53  CECPPSPPRC---------PLGVSLITDGCECCKMCAQQLGDNCTEAAIC------DPHR 97
           CEC P P +C         PLG+     GC+ C+ C +    +C++  IC      D H 
Sbjct: 530 CECRPRPKKCRPIICDKYCPLGLLKNKHGCDICR-CKKCPELSCSK--ICPLGFQQDSHG 586

Query: 98  GLYCD----YSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGC 153
            L C      +   P    G C  V       DG  + N +S+   C+  C C++G    
Sbjct: 587 CLICKCREASASAGPPILSGTCLTV-------DGHHHKNEESWHDGCR-ECYCLNG---- 634

Query: 154 TPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDD--AKRPRKTAP 197
             +C  +  P   C +P     PG CC    C DD   ++P  + P
Sbjct: 635 REMCALITCPVPACGNP--TIHPGQCCPS--CADDFVVQKPELSTP 676



 Score = 39.3 bits (90), Expect = 0.006
 Identities = 43/153 (28%), Positives = 54/153 (35%), Gaps = 38/153 (24%)

Query: 54  ECPP-SPPRCP-----LGVSLITDGC-------EC----CKMCAQQLGDNCTEAAICDPH 96
           ECPP     CP       V L  DGC       EC    C     ++G      +  D  
Sbjct: 259 ECPPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSGLCGFPVCEVGSTPRIVSRGDGT 318

Query: 97  RGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQ-PNCKYNCTCIDGAVGC-T 154
            G  CD         +  C       CV + V Y +G  F+  NC++ C C  G   C T
Sbjct: 319 PGKCCD---------VFECVNDTKPACVFNNVEYYDGDMFRMDNCRF-CRCQGGVAICFT 368

Query: 155 PLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCED 187
             C  +   R + P        G CC   VCED
Sbjct: 369 AQCGEINCERYYVPE-------GECCP--VCED 392



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 44/171 (25%), Positives = 62/171 (36%), Gaps = 18/171 (10%)

Query: 26  SPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGD 85
           S A   + F+P   ED+     +   P EC P P RC    +    GC   K+C  Q G+
Sbjct: 175 SKARCEVQFSPRCPEDSVLIEGYAP-PGECCPLPSRCVCNPA----GC-LRKVC--QPGN 226

Query: 86  NCTEAAICDPHRGLYCDYSGDRPRYAIGV----CAQVVGVGCVLDGVRYNNGQSFQPNCK 141
                +      G  CD    +P + +      C  V    C  D        +    C 
Sbjct: 227 LNILVSKASGKPGECCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCT 286

Query: 142 Y--NCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAK 190
               C C+ G  G  P+C     PR+     R    PG CC+ + C +D K
Sbjct: 287 LPTRCECLSGLCGF-PVCEVGSTPRIVS---RGDGTPGKCCDVFECVNDTK 333



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 31/107 (28%), Positives = 39/107 (36%), Gaps = 18/107 (16%)

Query: 59  PPRCPLGVSLITDGCECCKMCAQQLGDNCTEA----AICDPHRGLYC----DYSGDR-PR 109
           P  CP   S++   C CC  CA Q  ++C         CD  RGL C      +GD    
Sbjct: 48  PRNCP--GSIVQGVCGCCYTCASQRNESCGGTFGIYGTCD--RGLRCVIRPPLNGDSLTE 103

Query: 110 YAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPL 156
           Y  GVC         L G +  N      N    C  I+G   C  +
Sbjct: 104 YEAGVCEDENWTDDQLLGFKPCN-----ENLIAGCNIINGKCECNTI 145



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 19/67 (28%), Positives = 32/67 (47%), Gaps = 11/67 (16%)

Query: 122 GCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGC-TPLCLRVRPPRLWCPHPRRVSIPGHCC 180
           GC  +G+   +G  ++ +    C C++G   C   +C +       C +P  V +PG CC
Sbjct: 402 GCYANGLILAHGDRWREDDCTFCQCVNGERHCVATVCGQT------CTNP--VKVPGECC 453

Query: 181 EQWVCED 187
              VCE+
Sbjct: 454 P--VCEE 458



 Score = 28.9 bits (63), Expect = 7.6
 Identities = 32/119 (26%), Positives = 47/119 (39%), Gaps = 17/119 (14%)

Query: 134 QSFQPNCKYNCTCIDGAVGC-TPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRP 192
           +S++P+   +C CID  + C +  C     P + C  P  V   G CC    C +D   P
Sbjct: 765 ESWKPDVCTSCICIDSVISCFSESC-----PSVSCERP--VLRKGQCCP--YCIEDT-IP 814

Query: 193 RKTAPRDTGAFDAVGEVEAWHRNCIAY---TSPWSPCST-SCGLGVSTRISNVNAQCWP 247
           +K     +G   A  + E W  +   +       + CST SC         NV   C P
Sbjct: 815 KKVVCHFSG--KAYADEERWDLDSCTHCYCLQGQTLCSTVSCPPLPCVEPINVEGSCCP 871


>gi|161019170 mucin 5AC [Homo sapiens]
          Length = 6207

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 39/151 (25%), Positives = 54/151 (35%), Gaps = 15/151 (9%)

Query: 11   AVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLIT 70
            A  AA A  +      P  T ++++         +P+  + P  CP +   CPL +    
Sbjct: 938  AYLAACAQDLCRCPTCPCATFVEYS-RQCAHAGGQPRNWRCPELCPRT---CPLNMQHQE 993

Query: 71   DGCECCKMC-----AQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVL 125
             G  C   C     AQ   D+C +   C P R   C    D        C  +    C  
Sbjct: 994  CGSPCTDTCSNPQRAQLCEDHCVDGCFCPPGRS--CTVLDDITHSG---CLPLGQCPCTH 1048

Query: 126  DGVRYNNGQSFQPNCKYNCTCIDGAVGCTPL 156
             G  Y+ G SF   C  +CTC  G   C  L
Sbjct: 1049 GGRTYSPGTSFNTTCS-SCTCSGGLWQCQDL 1078


>gi|4504619 insulin-like growth factor binding protein 7 [Homo
           sapiens]
          Length = 282

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 33/98 (33%), Positives = 39/98 (39%), Gaps = 20/98 (20%)

Query: 52  PCECPPSPPR-CPLGVSLITDGCECCKMCAQQLGDNC----TEAAICDPHRGLYCDYSGD 106
           P  CPP PP  C LG +   D C CC MCA+  G+ C         C P  G+ C  S  
Sbjct: 37  PASCPPLPPLGCLLGET--RDACGCCPMCARGEGEPCGGGGAGRGYCAP--GMECVKSRK 92

Query: 107 RPRYAIGVCAQVVGVG-----------CVLDGVRYNNG 133
           R +   G  A   GV            C  DG  Y +G
Sbjct: 93  RRKGKAGAAAGGPGVSGVCVCKSRYPVCGSDGTTYPSG 130


>gi|169212026 PREDICTED: keratin associated protein [Homo sapiens]
          Length = 517

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 42/163 (25%), Positives = 55/163 (33%), Gaps = 13/163 (7%)

Query: 46  PQFCKWPCECPPS--PPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHR--GLYC 101
           P  C+ P  C PS   P CP     +T  C+            C+E++IC P     L C
Sbjct: 216 PSSCQ-PVVCEPSCCQPVCPTPTCSVTSSCQAVCCDPSPCEPTCSESSICQPATCVALVC 274

Query: 102 DYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTC---IDGAVGCTPLCL 158
           +    RP   +    +   V               QP C     C   +  +  C P C 
Sbjct: 275 EPVCLRPVCCVQSSCEPPSVPSTCQEPSCCVSSICQPICSEPSPCSPAVCVSSPCQPTCY 334

Query: 159 RVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRP---RKTAPR 198
            V+  R  CP P  VS P   C    C   +      R T PR
Sbjct: 335 VVKRCRSVCPEP--VSCPSTSCRPLSCSPGSSASAICRPTCPR 375



 Score = 29.3 bits (64), Expect = 5.8
 Identities = 60/294 (20%), Positives = 88/294 (29%), Gaps = 87/294 (29%)

Query: 49  CKWPCECPP--SPPRCPLGVSLITDGCE--CCKM-----------CAQQLGDNCTEAAIC 93
           C  P  C P    P C      ++ GC+  CC+            C Q +   C EA IC
Sbjct: 68  CAQPLCCDPVICEPSCS-----VSSGCQPVCCEATTCEPSCSVSNCYQPV---CFEATIC 119

Query: 94  DPHRGLYCDYSGD-----------RPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKY 142
           +P     C  S              P  ++  CAQ V   C    +        +P+C  
Sbjct: 120 EPS----CSVSNCCQPVCFEATICEPSCSVSSCAQPV---CCEPAI-------CEPSCSV 165

Query: 143 NCTCI---DGAVGCTP-LCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPR 198
           +  C      A  C P LC+      + C           CC+  VCE        T P 
Sbjct: 166 SSCCQPVGSEATSCQPVLCVPTSCQPVLCK--------SSCCQPVVCEPSCCSAVCTLPS 217

Query: 199 DTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRP 258
                           +C       S C   C     +  S+  A C        C+  P
Sbjct: 218 ----------------SCQPVVCEPSCCQPVCPTPTCSVTSSCQAVC--------CDPSP 253

Query: 259 CDVDI-HTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCI 311
           C+     + I     C+A+      +      C+ +    P     C +  CC+
Sbjct: 254 CEPTCSESSICQPATCVALVCEPVCLRPVC--CVQSSCEPPSVPSTCQEPSCCV 305


>gi|153945878 mucin 5, subtype B, tracheobronchial [Homo sapiens]
          Length = 5765

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 39/151 (25%), Positives = 54/151 (35%), Gaps = 15/151 (9%)

Query: 11  AVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLIT 70
           A  AA A  +      P  T ++++         +P+  + P  CP +   CPL +    
Sbjct: 282 AYLAACAQDLCRCPTCPCATFVEYS-RQCAHAGGQPRNWRCPELCPRT---CPLNMQHQE 337

Query: 71  DGCECCKMC-----AQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVL 125
            G  C   C     AQ   D+C +   C P R   C    D        C  +    C  
Sbjct: 338 CGSPCTDTCSNPQRAQLCEDHCVDGCFCPPGRS--CTVLDDITHSG---CLPLGQCPCTH 392

Query: 126 DGVRYNNGQSFQPNCKYNCTCIDGAVGCTPL 156
            G  Y+ G SF   C  +CTC  G   C  L
Sbjct: 393 GGRTYSPGTSFNTTCS-SCTCSGGLWQCQDL 422



 Score = 37.7 bits (86), Expect = 0.016
 Identities = 68/301 (22%), Positives = 87/301 (28%), Gaps = 58/301 (19%)

Query: 55   CPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGV 114
            CP S P CP G   I         C Q+ GD C     C P     C Y+G         
Sbjct: 5493 CPQSLPVCPPGQESI---------CTQEEGD-CCPTFRCRPQ---LCSYNGT-------- 5531

Query: 115  CAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAV-GCTPLCLRVRPPRLWCPHPRRV 173
                 GVG    G            C + CTC+ G     T  C         CP     
Sbjct: 5532 ---FYGVGATFPGAL---------PC-HMCTCLSGDTQDPTVQCQEDACNNTTCPQGFEY 5578

Query: 174  S-IPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSP-------WSP 225
              + G CC +  C   A       P           V+    NC  Y           +P
Sbjct: 5579 KRVAGQCCGE--CVQTACLTPDGQPVQLNETWVNSHVD----NCTVYLCEAEGGVHLLTP 5632

Query: 226  CSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNF 285
               SC    S R S     C        C    C V I+T I   + C    + E ++ F
Sbjct: 5633 QPASCPDVSSCRGSLRKTGCCYS-----CEEDSCQVRINTTILWHQGC----ETEVNITF 5683

Query: 286  TLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLS 345
                C     Y  +   +     CC   +     V   CP+G         ++ C C   
Sbjct: 5684 CEGSCPGASKYSAEAQAMQHQCTCCQERRVHEETVPLHCPNGSAILHTYTHVDECGCTPF 5743

Query: 346  C 346
            C
Sbjct: 5744 C 5744


>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
          Length = 1170

 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 34/143 (23%), Positives = 59/143 (41%), Gaps = 36/143 (25%)

Query: 123 CVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIP-GHCCE 181
           C  +GV+Y N + +  +    C C +       +C +V  P + C +    ++P G CC 
Sbjct: 318 CYHNGVQYRNNEEWTVDSCTECHCQNSVT----ICKKVSCPIMPCSN---ATVPDGECCP 370

Query: 182 QWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTR---I 238
           +    D A                    + W     +  S W+ CSTSCG G+  R    
Sbjct: 371 RCWPSDSAD-------------------DGW-----SPWSEWTSCSTSCGNGIQQRGRSC 406

Query: 239 SNVNAQC-WPEQESRLCNLRPCD 260
            ++N +C     ++R C+++ CD
Sbjct: 407 DSLNNRCEGSSVQTRTCHIQECD 429



 Score = 32.3 bits (72), Expect = 0.69
 Identities = 21/64 (32%), Positives = 29/64 (45%), Gaps = 11/64 (17%)

Query: 221 SPWSPCSTSCGLGVSTRISNVN--------AQCWPE-QESRLCNLRPCDVD--IHTLIKA 269
           SPW  CS +CG GV  R    N          C  +  E+++CN + C +D  +     A
Sbjct: 499 SPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFA 558

Query: 270 GKKC 273
           G KC
Sbjct: 559 GVKC 562


>gi|38490571 keratin associated protein 10-7 [Homo sapiens]
          Length = 370

 Score = 40.8 bits (94), Expect = 0.002
 Identities = 70/286 (24%), Positives = 92/286 (32%), Gaps = 65/286 (22%)

Query: 36  PAPLEDTSSRP-QFCKWPC---ECPPSPPRCPLGVSLITDGC--ECCKMCAQQLG---DN 86
           PAP       P  +   PC    C PSP  C  G    T  C   CC+  + QL     +
Sbjct: 49  PAPCLSLVCTPVSYVSSPCCRVTCEPSP--CQSGC---TSSCTPSCCQQSSCQLACCASS 103

Query: 87  CTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTC 146
             + A C P   + C     +P Y + VC+      C           S Q  C  +  C
Sbjct: 104 PCQQACCVP---VCCKTVCCKPVYCVPVCSG--DSSCCQQS-------SCQSACCTSSPC 151

Query: 147 IDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAV 206
                 C P+C +          P    I   CC+Q  C      P            AV
Sbjct: 152 QQAC--CVPICCK----------PVCSGISSSCCQQSSCVSCVSSP---------CCQAV 190

Query: 207 GEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTL 266
            E       CI+  +P     +SC     T      A C P     +C +  C  D    
Sbjct: 191 CEPSPCQSGCISSCTPSCCQQSSCKPACCTSSPCQQACCVPVCCKPVCCVPTCSDD---- 246

Query: 267 IKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIP 312
             +G  C    QP        A C S++S Q     VC    CC+P
Sbjct: 247 --SGSCC----QP--------ACCTSSQSQQGCCVPVCCKPVCCVP 278


>gi|239751787 PREDICTED: hypothetical protein XP_002348012 [Homo
            sapiens]
          Length = 3003

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 48/206 (23%), Positives = 65/206 (31%), Gaps = 65/206 (31%)

Query: 48   FCKWPCECPPSP------PRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYC 101
            FC  P ECPP+         C LG S ++   +C         D C E   CD   G   
Sbjct: 1527 FC--PMECPPNSHYELCADTCSLGCSALSAPPQC--------QDGCAEGCQCDS--GFL- 1573

Query: 102  DYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQ-PNCKYNCTCIDGAVGCTPLCLRV 160
             Y+G         C  +   GC  +GV Y   Q+    NC+  CTC              
Sbjct: 1574 -YNGQ-------ACVPIQQCGCYHNGVYYEPEQTVLIDNCRQQCTC-------------- 1611

Query: 161  RPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYT 220
                             H  +  VC++ + +P +      G    V +       C    
Sbjct: 1612 -----------------HAGKGMVCQEHSCKPGQVCQPSGGILSCVTKDPCHGVTC---- 1650

Query: 221  SPWSPCSTSCGLGVSTRISNVNAQCW 246
             P   C    G GV   + N  A CW
Sbjct: 1651 RPQETCKEQGGQGVC--LPNYEATCW 1674



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 34/115 (29%), Positives = 43/115 (37%), Gaps = 33/115 (28%)

Query: 45   RPQFCKWPCECPPSP------PRCPLGVSLIT--DGCECCKMCAQQLGDNCTEAAICDPH 96
            RP FC  P +CP           CP+    ++  +GCE            C E  +CD  
Sbjct: 2331 RPDFC--PLQCPAHSHYELCGDSCPVSCPSLSAPEGCESA----------CREGCVCDAG 2378

Query: 97   RGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQ--PNCKYNCTCIDG 149
              L    SGD        C  V   GC+ DG  Y  G+ F   P C+  C C  G
Sbjct: 2379 FVL----SGD-------TCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPG 2422



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 31/110 (28%), Positives = 39/110 (35%), Gaps = 31/110 (28%)

Query: 52   PCECPPSPPR------CPL--GVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDY 103
            P  CPP          CPL  G   +  GC          G  C E  +CD    L    
Sbjct: 1133 PLSCPPHSHYEACSYGCPLSCGDLPVPGGC----------GSECHEGCVCDEGFAL---- 1178

Query: 104  SGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQ--PNCKYNCTCIDGAV 151
            SG+        C  +   GCV  G  +  GQ+F   P C   C C +G +
Sbjct: 1179 SGES-------CLPLASCGCVHQGTYHPPGQTFYPGPGCDSLCHCQEGGL 1221



 Score = 29.6 bits (65), Expect = 4.5
 Identities = 28/103 (27%), Positives = 34/103 (33%), Gaps = 22/103 (21%)

Query: 52  PCECPPSPPRCPLGVSLITDGCECCKMC------AQQLGDNCTEAAICDPHRGLYCDYSG 105
           P  CP S   CP        G  C   C      +   G  C E  +C P  G     SG
Sbjct: 738 PANCPLS---CPANSRYELCGPACPTSCNGAAAPSNCSGRPCVEGCVCLP--GFVA--SG 790

Query: 106 DRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPN--CKYNCTC 146
                  G C      GC   G++   GQ    +  C+  CTC
Sbjct: 791 -------GACVPASSCGCTFQGLQLAPGQEVWADELCQRRCTC 826



 Score = 28.5 bits (62), Expect = 10.0
 Identities = 25/80 (31%), Positives = 34/80 (42%), Gaps = 6/80 (7%)

Query: 53   CECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGD-RPRYA 111
            C C  +    P+  SL+T  C     C+   G  C +AA C P  G  C+   + R  +A
Sbjct: 2774 CGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTC-QAAGCPP--GRVCEVKAEARNCWA 2830

Query: 112  I-GVCAQVVGVG-CVLDGVR 129
              G+C   VG      DG R
Sbjct: 2831 TRGLCVLSVGANLTTFDGAR 2850


>gi|169211819 PREDICTED: keratin associated protein [Homo sapiens]
          Length = 517

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 41/163 (25%), Positives = 55/163 (33%), Gaps = 13/163 (7%)

Query: 46  PQFCKWPCECPPS--PPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHR--GLYC 101
           P  C+ P  C PS   P CP     +T  C+           +C+E++IC P     L C
Sbjct: 216 PSSCQ-PVVCEPSCCQPVCPTPTCSVTSSCQAVCCDPSPCEPSCSESSICQPATCVALVC 274

Query: 102 DYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTC---IDGAVGCTPLCL 158
           +    RP   +    +   V               QP C     C   +  +  C P C 
Sbjct: 275 EPVCLRPVCCVQSSCEPPSVPSTCQEPSCCVSSICQPICSEPSPCSPAVCVSSPCQPTCY 334

Query: 159 RVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRP---RKTAPR 198
            V+     CP P  VS P   C    C   +      R T PR
Sbjct: 335 VVKRCPSVCPEP--VSCPSTSCRPLSCSPGSSASAICRPTCPR 375



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 58/290 (20%), Positives = 90/290 (31%), Gaps = 79/290 (27%)

Query: 49  CKWPCECPP--SPPRCPLGVSLITDGCE--CCKM-----------CAQQLGDNCTEAAIC 93
           C  P  C P    P C      ++ GC+  CC+            C Q +   C EA IC
Sbjct: 68  CAQPLCCDPVICEPSCS-----VSSGCQPVCCEATTCEPSCSVSNCYQPV---CFEATIC 119

Query: 94  DPH-------RGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTC 146
           +P        + +  + +   P  ++  CAQ V   C    +        +P+C  +  C
Sbjct: 120 EPSCSVSNCCQPVCFEATVCEPSCSVSSCAQPV---CCEPAI-------CEPSCSVSSCC 169

Query: 147 I---DGAVGCTP-LCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGA 202
                 A  C P LC+      + C           CC+  VCE        T P     
Sbjct: 170 QPVGSEATSCQPVLCVPTSCQPVLCK--------SSCCQPVVCEPSCCSAVCTLPS---- 217

Query: 203 FDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVD 262
                       +C       S C   C     +  S+  A C        C+  PC+  
Sbjct: 218 ------------SCQPVVCEPSCCQPVCPTPTCSVTSSCQAVC--------CDPSPCEPS 257

Query: 263 I-HTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCI 311
              + I     C+A+      +      C+ +    P     C +  CC+
Sbjct: 258 CSESSICQPATCVALVCEPVCLRPVC--CVQSSCEPPSVPSTCQEPSCCV 305


>gi|239745811 PREDICTED: hypothetical protein XP_002343557 [Homo
           sapiens]
          Length = 517

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 41/163 (25%), Positives = 55/163 (33%), Gaps = 13/163 (7%)

Query: 46  PQFCKWPCECPPS--PPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHR--GLYC 101
           P  C+ P  C PS   P CP     +T  C+           +C+E++IC P     L C
Sbjct: 216 PSSCQ-PVVCEPSCCQPVCPTPTCSVTSSCQAVCCDPSPCEPSCSESSICQPATCVALVC 274

Query: 102 DYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTC---IDGAVGCTPLCL 158
           +    RP   +    +   V               QP C     C   +  +  C P C 
Sbjct: 275 EPVCLRPVCCVQSSCEPPSVPSTCQEPSCCVSSICQPICSEPSPCSPAVCVSSPCQPTCY 334

Query: 159 RVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRP---RKTAPR 198
            V+     CP P  VS P   C    C   +      R T PR
Sbjct: 335 VVKRCPSVCPEP--VSCPSTSCRPLSCSPGSSASAICRPTCPR 375



 Score = 30.0 bits (66), Expect = 3.4
 Identities = 58/290 (20%), Positives = 90/290 (31%), Gaps = 79/290 (27%)

Query: 49  CKWPCECPP--SPPRCPLGVSLITDGCE--CCKM-----------CAQQLGDNCTEAAIC 93
           C  P  C P    P C      ++ GC+  CC+            C Q +   C EA IC
Sbjct: 68  CAQPLCCDPVICEPSCS-----VSSGCQPVCCEATTCEPSCSVSNCYQPV---CFEATIC 119

Query: 94  DPH-------RGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTC 146
           +P        + +  + +   P  ++  CAQ V   C    +        +P+C  +  C
Sbjct: 120 EPSCSVSNCCQPVCFEATVCEPSCSVSSCAQPV---CCEPAI-------CEPSCSVSSCC 169

Query: 147 I---DGAVGCTP-LCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGA 202
                 A  C P LC+      + C           CC+  VCE        T P     
Sbjct: 170 QPVGSEATSCQPVLCVPTSCQPVLCK--------SSCCQPVVCEPSCCSAVCTLPS---- 217

Query: 203 FDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVD 262
                       +C       S C   C     +  S+  A C        C+  PC+  
Sbjct: 218 ------------SCQPVVCEPSCCQPVCPTPTCSVTSSCQAVC--------CDPSPCEPS 257

Query: 263 I-HTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCI 311
              + I     C+A+      +      C+ +    P     C +  CC+
Sbjct: 258 CSESSICQPATCVALVCEPVCLRPVC--CVQSSCEPPSVPSTCQEPSCCV 305


>gi|154146262 Fc fragment of IgG binding protein [Homo sapiens]
          Length = 5405

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 48/206 (23%), Positives = 65/206 (31%), Gaps = 65/206 (31%)

Query: 48   FCKWPCECPPSP------PRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYC 101
            FC  P ECPP+         C LG S ++   +C         D C E   CD   G   
Sbjct: 1527 FC--PMECPPNSHYELCADTCSLGCSALSAPPQC--------QDGCAEGCQCDS--GFL- 1573

Query: 102  DYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQ-PNCKYNCTCIDGAVGCTPLCLRV 160
             Y+G         C  +   GC  +GV Y   Q+    NC+  CTC              
Sbjct: 1574 -YNGQ-------ACVPIQQCGCYHNGVYYEPEQTVLIDNCRQQCTC-------------- 1611

Query: 161  RPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYT 220
                             H  +  VC++ + +P +      G    V +       C    
Sbjct: 1612 -----------------HAGKGMVCQEHSCKPGQVCQPSGGILSCVTKDPCHGVTC---- 1650

Query: 221  SPWSPCSTSCGLGVSTRISNVNAQCW 246
             P   C    G GV   + N  A CW
Sbjct: 1651 RPQETCKEQGGQGVC--LPNYEATCW 1674



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 40/123 (32%), Positives = 46/123 (37%), Gaps = 36/123 (29%)

Query: 45   RPQFCKWPCE-------CPPS-PPRCPLGVSLIT-DGCECCKMCAQQLGDNCTEAAICDP 95
            RP FC + C        C  S P  CP   SL   +GCE            C E  +CD 
Sbjct: 2329 RPDFCPFQCPAHSHYELCGDSCPGSCP---SLSAPEGCESA----------CREGCVCDA 2375

Query: 96   HRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQ--PNCKYNCTCIDGA-VG 152
               L    SGD        C  V   GC+ D   Y  GQ+F   P C   C C +G  V 
Sbjct: 2376 GFVL----SGD-------TCVPVGQCGCLHDDRYYPLGQTFYPGPGCDSLCRCREGGEVS 2424

Query: 153  CTP 155
            C P
Sbjct: 2425 CEP 2427



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 40/123 (32%), Positives = 46/123 (37%), Gaps = 36/123 (29%)

Query: 45   RPQFCKWPCE-------CPPS-PPRCPLGVSLIT-DGCECCKMCAQQLGDNCTEAAICDP 95
            RP FC + C        C  S P  CP   SL   +GCE            C E  +CD 
Sbjct: 3530 RPDFCPFQCPAHSHYELCGDSCPGSCP---SLSAPEGCESA----------CREGCVCDA 3576

Query: 96   HRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQ--PNCKYNCTCIDGA-VG 152
               L    SGD        C  V   GC+ D   Y  GQ+F   P C   C C +G  V 
Sbjct: 3577 GFVL----SGD-------TCVPVGQCGCLHDDRYYPLGQTFYPGPGCDSLCRCREGGEVS 3625

Query: 153  CTP 155
            C P
Sbjct: 3626 CEP 3628



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 34/115 (29%), Positives = 43/115 (37%), Gaps = 33/115 (28%)

Query: 45   RPQFCKWPCECPPSP------PRCPLGVSLIT--DGCECCKMCAQQLGDNCTEAAICDPH 96
            RP FC  P +CP           CP+    ++  +GCE            C E  +CD  
Sbjct: 4731 RPDFC--PLQCPAHSHYELCGDSCPVSCPSLSAPEGCESA----------CREGCVCDAG 4778

Query: 97   RGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQ--PNCKYNCTCIDG 149
              L    SGD        C  V   GC+ DG  Y  G+ F   P C+  C C  G
Sbjct: 4779 FVL----SGD-------TCVPVGQCGCLHDGRYYPLGEVFYPGPECERRCECGPG 4822



 Score = 37.0 bits (84), Expect = 0.028
 Identities = 33/111 (29%), Positives = 42/111 (37%), Gaps = 28/111 (25%)

Query: 48   FCKWPCECPPSP------PRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYC 101
            FC  P ECP +         C LG S ++   +C         D C E   CD   G   
Sbjct: 3929 FC--PMECPQNSHYELCADTCSLGCSALSAPLQC--------PDGCAEGCQCDS--GFL- 3975

Query: 102  DYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQ-PNCKYNCTCIDGAV 151
             Y+G         C  +   GC  +GV Y   Q+    NC+  CTC  G V
Sbjct: 3976 -YNGQ-------ACVPIQQCGCYHNGVYYEPEQTVLIDNCRQQCTCHVGKV 4018



 Score = 36.2 bits (82), Expect = 0.048
 Identities = 46/206 (22%), Positives = 63/206 (30%), Gaps = 65/206 (31%)

Query: 48   FCKWPCECPPSP------PRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYC 101
            FC  P ECP +         C LG S ++   +C         D C E   CD   G   
Sbjct: 2728 FC--PMECPQNSHYELCADTCSLGCSALSAPLQC--------PDGCAEGCQCDS--GFL- 2774

Query: 102  DYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQ-PNCKYNCTCIDGAVGCTPLCLRV 160
             Y+G         C  +   GC  +G  Y   Q+    NC+  CTC              
Sbjct: 2775 -YNGQ-------ACVPIQQCGCYHNGAYYEPEQTVLIDNCRQQCTC-------------- 2812

Query: 161  RPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYT 220
                             H  +  VC++ + +P +      G    V +       C    
Sbjct: 2813 -----------------HVGKVVVCQEHSCKPGQVCQPSGGILSCVNKDPCHGVTC---- 2851

Query: 221  SPWSPCSTSCGLGVSTRISNVNAQCW 246
             P   C    G GV   + N  A CW
Sbjct: 2852 RPQETCKEQGGQGVC--LPNYEATCW 2875



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 31/110 (28%), Positives = 39/110 (35%), Gaps = 31/110 (28%)

Query: 52   PCECPPSPPR------CPL--GVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDY 103
            P  CPP          CPL  G   +  GC          G  C E  +CD    L    
Sbjct: 1133 PLSCPPHSHYEACSYGCPLSCGDLPVPGGC----------GSECHEGCVCDEGFAL---- 1178

Query: 104  SGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQ--PNCKYNCTCIDGAV 151
            SG+        C  +   GCV  G  +  GQ+F   P C   C C +G +
Sbjct: 1179 SGES-------CLPLASCGCVHQGTYHPPGQTFYPGPGCDSLCHCQEGGL 1221



 Score = 29.6 bits (65), Expect = 4.5
 Identities = 28/103 (27%), Positives = 34/103 (33%), Gaps = 22/103 (21%)

Query: 52  PCECPPSPPRCPLGVSLITDGCECCKMC------AQQLGDNCTEAAICDPHRGLYCDYSG 105
           P  CP S   CP        G  C   C      +   G  C E  +C P  G     SG
Sbjct: 738 PANCPLS---CPANSRYELCGPACPTSCNGAAAPSNCSGRPCVEGCVCLP--GFVA--SG 790

Query: 106 DRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPN--CKYNCTC 146
                  G C      GC   G++   GQ    +  C+  CTC
Sbjct: 791 -------GACVPASSCGCTFQGLQLAPGQEVWADELCQRRCTC 826



 Score = 28.5 bits (62), Expect = 10.0
 Identities = 25/80 (31%), Positives = 34/80 (42%), Gaps = 6/80 (7%)

Query: 53   CECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGD-RPRYA 111
            C C  +    P+  SL+T  C     C+   G  C +AA C P  G  C+   + R  +A
Sbjct: 5174 CGCTHNGRYLPVNSSLLTSDCSERCSCSSSSGLTC-QAAGCPP--GRVCEVKAEARNCWA 5230

Query: 112  I-GVCAQVVGVG-CVLDGVR 129
              G+C   VG      DG R
Sbjct: 5231 TRGLCVLSVGANLTTFDGAR 5250


>gi|239757284 PREDICTED: similar to Fc fragment of IgG binding
           protein [Homo sapiens]
          Length = 593

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 34/111 (30%), Positives = 43/111 (38%), Gaps = 28/111 (25%)

Query: 48  FCKWPCECPPSP------PRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYC 101
           FC  P ECPP+         C LG S ++   +C         D C E   CD   G   
Sbjct: 192 FC--PMECPPNSHYELCADTCSLGCSALSAPPQC--------QDGCAEGCQCDS--GFL- 238

Query: 102 DYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQ-PNCKYNCTCIDGAV 151
            Y+G         C  +   GC  +GV Y   Q+    NC+  CTC  G V
Sbjct: 239 -YNGQ-------ACVPIQQCGCYHNGVYYEPEQTVLIDNCRQQCTCHAGKV 281


>gi|114431244 von Willebrand factor C and EGF domains [Homo sapiens]
          Length = 955

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 44/166 (26%), Positives = 59/166 (35%), Gaps = 21/166 (12%)

Query: 38  PLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHR 97
           P E+    P  C + C+ P     C    SL  +G E         GD C E  IC    
Sbjct: 544 PREEWRLGPGQCCFTCQEPTPSTGC----SLDDNGVEFPIGQIWSPGDPC-ELCICQADG 598

Query: 98  GLYCDY-----SGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCK--YNCTCIDGA 150
            + C       S   P    G C      GC   G  + N ++F        +C C+ G+
Sbjct: 599 SVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGS 658

Query: 151 VGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTA 196
           V C+P+   +      C +P      G CC   VC D     RK A
Sbjct: 659 VACSPVDCPIT-----CTYPFHPD--GECCP--VCRDCNYEGRKVA 695



 Score = 31.6 bits (70), Expect = 1.2
 Identities = 31/115 (26%), Positives = 42/115 (36%), Gaps = 21/115 (18%)

Query: 115 CAQVVGVGCVLDGVRYNNGQSFQ---PNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPR 171
           C   V V C   G  Y +G  F      C   C C +G V C+ +      P L CP   
Sbjct: 493 CCTCVPVRCYFHGRWYADGAVFSGGGDECT-TCVCQNGEVECSFMPC----PELACPREE 547

Query: 172 RVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPC 226
               PG CC  + C++       +   D G    +G++  W        SP  PC
Sbjct: 548 WRLGPGQCC--FTCQEPTPSTGCSLD-DNGVEFPIGQI--W--------SPGDPC 589


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score = 39.3 bits (90), Expect = 0.006
 Identities = 20/56 (35%), Positives = 27/56 (48%), Gaps = 1/56 (1%)

Query: 288  AGCISTRSYQPKYC-GVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFC 342
            A C +T+      C G C   +CC P +SK    SF+C DG  F  +V  +  C C
Sbjct: 1469 AACQTTKKVSRLECRGGCAGGQCCGPLRSKRRKYSFECTDGSSFVDEVEKVVKCGC 1524


>gi|34147715 chordin-like 1 isoform 3 precursor [Homo sapiens]
          Length = 456

 Score = 38.5 bits (88), Expect = 0.010
 Identities = 27/84 (32%), Positives = 36/84 (42%), Gaps = 19/84 (22%)

Query: 117 QVVGVGCVLDGVRYNNGQSF---------QPNCKYNCTCIDGAVGC-TPLCLRVRPPRLW 166
           +V    C  +G  Y +G+ F         QPN    C+C +G V C    C     P+L 
Sbjct: 109 KVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTC-----PKLT 163

Query: 167 CPHPRRVSIPGHCCEQWVCEDDAK 190
           C  P  VS+P  CC   VC  D +
Sbjct: 164 CAFP--VSVPDSCCR--VCRGDGE 183



 Score = 33.9 bits (76), Expect = 0.24
 Identities = 30/101 (29%), Positives = 43/101 (42%), Gaps = 26/101 (25%)

Query: 96  HRGLYCDYSGDRPRYAIGVCAQVV-------GVGCVLDGVRYNNGQSFQPNCK------- 141
           HRG   D      + A G   Q+V       G  CV +G  Y++G+S+ PN +       
Sbjct: 231 HRGALMD-----SQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVEC 285

Query: 142 YNCTCIDGAVGCTPL-CLRVRPPRLWCPHPRRVSIPGHCCE 181
             CTC      C  + C    P R  C +P++  I G CC+
Sbjct: 286 VLCTCNVTKQECKKIHC----PNRYPCKYPQK--IDGKCCK 320



 Score = 31.2 bits (69), Expect = 1.5
 Identities = 22/72 (30%), Positives = 30/72 (41%), Gaps = 14/72 (19%)

Query: 123 CVLDGVRYNNGQSFQPNCK-------YNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSI 175
           C+    +Y  G+ + P  +        NC C +       LC RVR P + C  P  V I
Sbjct: 37  CMFQDKKYRVGERWHPYLEPYGLVYCVNCICSENG---NVLCSRVRCPNVHCLSP--VHI 91

Query: 176 PGHCCEQWVCED 187
           P  CC +  C D
Sbjct: 92  PHLCCPR--CPD 101


>gi|221316563 chordin-like 1 isoform 2 precursor [Homo sapiens]
          Length = 457

 Score = 38.5 bits (88), Expect = 0.010
 Identities = 27/84 (32%), Positives = 36/84 (42%), Gaps = 19/84 (22%)

Query: 117 QVVGVGCVLDGVRYNNGQSF---------QPNCKYNCTCIDGAVGC-TPLCLRVRPPRLW 166
           +V    C  +G  Y +G+ F         QPN    C+C +G V C    C     P+L 
Sbjct: 109 KVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTC-----PKLT 163

Query: 167 CPHPRRVSIPGHCCEQWVCEDDAK 190
           C  P  VS+P  CC   VC  D +
Sbjct: 164 CAFP--VSVPDSCCR--VCRGDGE 183



 Score = 33.9 bits (76), Expect = 0.24
 Identities = 30/101 (29%), Positives = 43/101 (42%), Gaps = 26/101 (25%)

Query: 96  HRGLYCDYSGDRPRYAIGVCAQVV-------GVGCVLDGVRYNNGQSFQPNCK------- 141
           HRG   D      + A G   Q+V       G  CV +G  Y++G+S+ PN +       
Sbjct: 231 HRGALMD-----SQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVEC 285

Query: 142 YNCTCIDGAVGCTPL-CLRVRPPRLWCPHPRRVSIPGHCCE 181
             CTC      C  + C    P R  C +P++  I G CC+
Sbjct: 286 VLCTCNVTKQECKKIHC----PNRYPCKYPQK--IDGKCCK 320



 Score = 31.2 bits (69), Expect = 1.5
 Identities = 22/72 (30%), Positives = 30/72 (41%), Gaps = 14/72 (19%)

Query: 123 CVLDGVRYNNGQSFQPNCK-------YNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSI 175
           C+    +Y  G+ + P  +        NC C +       LC RVR P + C  P  V I
Sbjct: 37  CMFQDKKYRVGERWHPYLEPYGLVYCVNCICSENG---NVLCSRVRCPNVHCLSP--VHI 91

Query: 176 PGHCCEQWVCED 187
           P  CC +  C D
Sbjct: 92  PHLCCPR--CPD 101


>gi|221316561 chordin-like 1 isoform 1 precursor [Homo sapiens]
          Length = 458

 Score = 38.5 bits (88), Expect = 0.010
 Identities = 27/84 (32%), Positives = 36/84 (42%), Gaps = 19/84 (22%)

Query: 117 QVVGVGCVLDGVRYNNGQSF---------QPNCKYNCTCIDGAVGC-TPLCLRVRPPRLW 166
           +V    C  +G  Y +G+ F         QPN    C+C +G V C    C     P+L 
Sbjct: 110 KVTSKSCEYNGTTYQHGELFVAEGLFQNRQPNQCTQCSCSEGNVYCGLKTC-----PKLT 164

Query: 167 CPHPRRVSIPGHCCEQWVCEDDAK 190
           C  P  VS+P  CC   VC  D +
Sbjct: 165 CAFP--VSVPDSCCR--VCRGDGE 184



 Score = 33.9 bits (76), Expect = 0.24
 Identities = 30/101 (29%), Positives = 43/101 (42%), Gaps = 26/101 (25%)

Query: 96  HRGLYCDYSGDRPRYAIGVCAQVV-------GVGCVLDGVRYNNGQSFQPNCK------- 141
           HRG   D      + A G   Q+V       G  CV +G  Y++G+S+ PN +       
Sbjct: 232 HRGALMD-----SQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVEC 286

Query: 142 YNCTCIDGAVGCTPL-CLRVRPPRLWCPHPRRVSIPGHCCE 181
             CTC      C  + C    P R  C +P++  I G CC+
Sbjct: 287 VLCTCNVTKQECKKIHC----PNRYPCKYPQK--IDGKCCK 321



 Score = 33.5 bits (75), Expect = 0.31
 Identities = 23/77 (29%), Positives = 33/77 (42%), Gaps = 14/77 (18%)

Query: 123 CVLDGVRYNNGQSFQPNCK-------YNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSI 175
           C+    +Y  G+ + P  +        NC C +       LC RVR P + C  P  V I
Sbjct: 37  CMFQDKKYRVGERWHPYLEPYGLVYCVNCICSENG---NVLCSRVRCPNVHCLSP--VHI 91

Query: 176 PGHCCEQWVCEDDAKRP 192
           P  CC +  C +D+  P
Sbjct: 92  PHLCCPR--CPEDSLPP 106


>gi|40353769 chordin-like 2 [Homo sapiens]
          Length = 451

 Score = 38.5 bits (88), Expect = 0.010
 Identities = 23/69 (33%), Positives = 33/69 (47%), Gaps = 12/69 (17%)

Query: 123 CVLDGVRYNNGQSFQPNCK-------YNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSI 175
           C+  G RY+ G+S+ P  +         CTC +GA      C R+  P + CP P  V+ 
Sbjct: 33  CLFHGKRYSPGESWHPYLEPQGLMYCLRCTCSEGA---HVSCYRLHCPPVHCPQP--VTE 87

Query: 176 PGHCCEQWV 184
           P  CC + V
Sbjct: 88  PQQCCPKCV 96


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.138    0.490 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,155,040
Number of Sequences: 37866
Number of extensions: 907587
Number of successful extensions: 4165
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 125
Number of HSP's that attempted gapping in prelim test: 3591
Number of HSP's gapped (non-prelim): 625
length of query: 367
length of database: 18,247,518
effective HSP length: 104
effective length of query: 263
effective length of database: 14,309,454
effective search space: 3763386402
effective search space used: 3763386402
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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