Search of human proteins with 4507703

Search of human proteins with 4507703

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4507703 tumor suppressing subtransferable candidate 1 [Homo
sapiens]
         (387 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4507703 tumor suppressing subtransferable candidate 1 [Homo s...   801   0.0  
gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]             73   5e-13
gi|207029439 retinoblastoma binding protein 4 isoform c [Homo sa...    71   1e-12
gi|207029415 retinoblastoma binding protein 4 isoform b [Homo sa...    71   1e-12
gi|5032027 retinoblastoma binding protein 4 isoform a [Homo sapi...    71   1e-12
gi|58331266 WD repeat domain 59 [Homo sapiens]                         64   2e-10
gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]              59   7e-09
gi|14149696 SEC31 homolog B [Homo sapiens]                             58   2e-08
gi|110815800 WD repeat domain 32 [Homo sapiens]                        55   1e-07
gi|24308452 WD repeat domain 85 [Homo sapiens]                         53   4e-07
gi|19913369 transducin beta-like 3 [Homo sapiens]                      53   5e-07
gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]      51   2e-06
gi|217330644 WD repeat domain 12 protein [Homo sapiens]                50   3e-06
gi|13129110 WD repeat domain 77 [Homo sapiens]                         50   3e-06
gi|38605733 nucleoporin 43kDa [Homo sapiens]                           48   1e-05
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...    48   2e-05
gi|109627650 coronin 6 [Homo sapiens]                                  48   2e-05
gi|23199987 WD repeat domain 5B [Homo sapiens]                         47   2e-05
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ...    47   3e-05
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]               46   5e-05
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]               46   5e-05
gi|14149987 WD repeat domain 24 [Homo sapiens]                         46   5e-05
gi|8923881 WD SOCS-box protein 2 [Homo sapiens]                        46   6e-05
gi|78482617 general transcription factor IIIC, polypeptide 2, be...    45   1e-04
gi|4504205 general transcription factor IIIC, polypeptide 2, bet...    45   1e-04
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            45   1e-04
gi|4502477 beta-transducin repeat containing protein isoform 2 [...    44   2e-04
gi|16117783 beta-transducin repeat containing protein isoform 1 ...    44   2e-04
gi|4757988 WD repeat domain 39 [Homo sapiens]                          44   2e-04
gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo sa...    44   2e-04

>gi|4507703 tumor suppressing subtransferable candidate 1 [Homo
           sapiens]
          Length = 387

 Score =  801 bits (2068), Expect = 0.0
 Identities = 387/387 (100%), Positives = 387/387 (100%)

Query: 1   MEDDAPVIYGLEFQARALTPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVL 60
           MEDDAPVIYGLEFQARALTPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVL
Sbjct: 1   MEDDAPVIYGLEFQARALTPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVL 60

Query: 61  LHQAGEIWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSSSTA 120
           LHQAGEIWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSSSTA
Sbjct: 61  LHQAGEIWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSSSTA 120

Query: 121 QTLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLE 180
           QTLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLE
Sbjct: 121 QTLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLE 180

Query: 181 GKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNK 240
           GKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNK
Sbjct: 181 GKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNK 240

Query: 241 QYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILS 300
           QYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILS
Sbjct: 241 QYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILS 300

Query: 301 NMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADP 360
           NMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADP
Sbjct: 301 NMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADP 360

Query: 361 WLFASLSYDGRLVINRVPRALKYHILL 387
           WLFASLSYDGRLVINRVPRALKYHILL
Sbjct: 361 WLFASLSYDGRLVINRVPRALKYHILL 387


>gi|4506439 retinoblastoma binding protein 7 [Homo sapiens]
          Length = 425

 Score = 72.8 bits (177), Expect = 5e-13
 Identities = 52/227 (22%), Positives = 96/227 (42%), Gaps = 21/227 (9%)

Query: 151 IISLADNH-ILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTL 209
           ++S +D+H + LWD+     +  +  + ++            W   H     + A+D  L
Sbjct: 192 LLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKL 251

Query: 210 RGWDTRS--MSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKT 267
             WDTRS   S+   + +AH   V  L FNP  ++ LA+   D  V  WD RN+   + T
Sbjct: 252 MIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHT 311

Query: 268 LEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRS 327
            E H   ++ V ++  ++ ++ +  +D R+ + ++  I  E            D ED   
Sbjct: 312 FESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEE--------QSAEDAEDGPP 363

Query: 328 EEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSYDGRLVI 374
           E          ++  +  H   +    W+  +PW+  S+S D  + I
Sbjct: 364 E----------LLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQI 400



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 45/208 (21%), Positives = 76/208 (36%), Gaps = 27/208 (12%)

Query: 67  IWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSS-----STAQ 121
           +W I+A P +  ++      T  S V+   A W +  E   GS    DD       + + 
Sbjct: 203 LWDINAGPKEGKIVDAKAIFTGHSAVVEDVA-WHLLHESLFGS--VADDQKLMIWDTRSN 259

Query: 122 TLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEG 181
           T     HL +     + C+ + P  +       AD  + LWDL+    +     S   E 
Sbjct: 260 TTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDE- 318

Query: 182 KGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENA-------------HG 228
                     WSPH+     ++  D  L  WD   + +    E+A             H 
Sbjct: 319 -----IFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHT 373

Query: 229 QLVRDLDFNPNKQYYLASCGDDCKVKFW 256
             + D  +NPN+ + + S  +D  ++ W
Sbjct: 374 AKISDFSWNPNEPWVICSVSEDNIMQIW 401



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 39/168 (23%), Positives = 66/168 (39%), Gaps = 37/168 (22%)

Query: 234 LDFNPNKQYYLASCGDDCKVKFWDTR------NVTEPVKTLEEHSHWVWNVRYNHSHDQL 287
           L +N N   +L S  DD  V  WD         + +       HS  V +V ++  H+ L
Sbjct: 182 LSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESL 241

Query: 288 VLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEK--SKEPLQDNVIA---- 341
             + + D ++++ +  S ++    HLVD         H +E    S  P  + ++A    
Sbjct: 242 FGSVADDQKLMIWDTRSNTTSKPSHLVD--------AHTAEVNCLSFNPYSEFILATGSA 293

Query: 342 -----------------TYEEHEDSVYAVDWSSADPWLFASLSYDGRL 372
                            T+E H+D ++ V WS  +  + AS   D RL
Sbjct: 294 DKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRL 341


>gi|207029439 retinoblastoma binding protein 4 isoform c [Homo
           sapiens]
          Length = 390

 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 71/328 (21%), Positives = 127/328 (38%), Gaps = 45/328 (13%)

Query: 48  FDDENNIINKNVLLHQAGEIWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELES 107
           F   +  I   + ++  GE+      P +  ++ T   +T  S VL            + 
Sbjct: 73  FGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIAT---KTPSSDVLV----------FDY 119

Query: 108 GSHES-PDDSSSTAQTLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQE 166
             H S PD S      L L  H     +G    + W P   G  + +  D+ I LWD+  
Sbjct: 120 TKHPSKPDPSGECNPDLRLRGH-QKEGYG----LSWNPNLSGHLLSASDDHTICLWDISA 174

Query: 167 SSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRS--MSQIYCIE 224
              +  +  + ++            W   H     + A+D  L  WDTRS   S+     
Sbjct: 175 VPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSV 234

Query: 225 NAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSH 284
           +AH   V  L FNP  ++ LA+   D  V  WD RN+   + + E H   ++ V+++  +
Sbjct: 235 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN 294

Query: 285 DQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQD---NVIA 341
           + ++ +  +D R+ + ++  I                      EE+S E  +D    ++ 
Sbjct: 295 ETILASSGTDRRLNVWDLSKI---------------------GEEQSPEDAEDGPPELLF 333

Query: 342 TYEEHEDSVYAVDWSSADPWLFASLSYD 369
            +  H   +    W+  +PW+  S+S D
Sbjct: 334 IHGGHTAKISDFSWNPNEPWVICSVSED 361



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 40/189 (21%), Positives = 84/189 (44%), Gaps = 39/189 (20%)

Query: 192 WSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENA------HGQLVRDLDFNPNKQYYLA 245
           W+P+ +   ++ ++D T+  WD  ++ +   + +A      H  +V D+ ++   +    
Sbjct: 150 WNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFG 209

Query: 246 SCGDDCKVKFWDTR--NVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMV 303
           S  DD K+  WDTR  N ++P  +++ H+  V  + +N   + ++ TGS+D  V L ++ 
Sbjct: 210 SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 269

Query: 304 SISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLF 363
           ++  +                               + ++E H+D ++ V WS  +  + 
Sbjct: 270 NLKLK-------------------------------LHSFESHKDEIFQVQWSPHNETIL 298

Query: 364 ASLSYDGRL 372
           AS   D RL
Sbjct: 299 ASSGTDRRL 307



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 42/208 (20%), Positives = 74/208 (35%), Gaps = 27/208 (12%)

Query: 67  IWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSS-----STAQ 121
           +W ISA P +  V+      T  + V+   + W +  E   GS    DD       + + 
Sbjct: 169 LWDISAVPKEGKVVDAKTIFTGHTAVVEDVS-WHLLHESLFGS--VADDQKLMIWDTRSN 225

Query: 122 TLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEG 181
                 H  +     + C+ + P  +       AD  + LWDL+    +     S   E 
Sbjct: 226 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE- 284

Query: 182 KGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQ-------------IYCIENAHG 228
                    +WSPH+     ++  D  L  WD   + +             +  I   H 
Sbjct: 285 -----IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHT 339

Query: 229 QLVRDLDFNPNKQYYLASCGDDCKVKFW 256
             + D  +NPN+ + + S  +D  ++ W
Sbjct: 340 AKISDFSWNPNEPWVICSVSEDNIMQVW 367


>gi|207029415 retinoblastoma binding protein 4 isoform b [Homo
           sapiens]
          Length = 424

 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 71/328 (21%), Positives = 127/328 (38%), Gaps = 45/328 (13%)

Query: 48  FDDENNIINKNVLLHQAGEIWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELES 107
           F   +  I   + ++  GE+      P +  ++ T   +T  S VL            + 
Sbjct: 107 FGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIAT---KTPSSDVLV----------FDY 153

Query: 108 GSHES-PDDSSSTAQTLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQE 166
             H S PD S      L L  H     +G    + W P   G  + +  D+ I LWD+  
Sbjct: 154 TKHPSKPDPSGECNPDLRLRGH-QKEGYG----LSWNPNLSGHLLSASDDHTICLWDISA 208

Query: 167 SSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRS--MSQIYCIE 224
              +  +  + ++            W   H     + A+D  L  WDTRS   S+     
Sbjct: 209 VPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSV 268

Query: 225 NAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSH 284
           +AH   V  L FNP  ++ LA+   D  V  WD RN+   + + E H   ++ V+++  +
Sbjct: 269 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN 328

Query: 285 DQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQD---NVIA 341
           + ++ +  +D R+ + ++  I                      EE+S E  +D    ++ 
Sbjct: 329 ETILASSGTDRRLNVWDLSKI---------------------GEEQSPEDAEDGPPELLF 367

Query: 342 TYEEHEDSVYAVDWSSADPWLFASLSYD 369
            +  H   +    W+  +PW+  S+S D
Sbjct: 368 IHGGHTAKISDFSWNPNEPWVICSVSED 395



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 40/189 (21%), Positives = 84/189 (44%), Gaps = 39/189 (20%)

Query: 192 WSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENA------HGQLVRDLDFNPNKQYYLA 245
           W+P+ +   ++ ++D T+  WD  ++ +   + +A      H  +V D+ ++   +    
Sbjct: 184 WNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFG 243

Query: 246 SCGDDCKVKFWDTR--NVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMV 303
           S  DD K+  WDTR  N ++P  +++ H+  V  + +N   + ++ TGS+D  V L ++ 
Sbjct: 244 SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 303

Query: 304 SISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLF 363
           ++  +                               + ++E H+D ++ V WS  +  + 
Sbjct: 304 NLKLK-------------------------------LHSFESHKDEIFQVQWSPHNETIL 332

Query: 364 ASLSYDGRL 372
           AS   D RL
Sbjct: 333 ASSGTDRRL 341



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 42/208 (20%), Positives = 74/208 (35%), Gaps = 27/208 (12%)

Query: 67  IWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSS-----STAQ 121
           +W ISA P +  V+      T  + V+   + W +  E   GS    DD       + + 
Sbjct: 203 LWDISAVPKEGKVVDAKTIFTGHTAVVEDVS-WHLLHESLFGS--VADDQKLMIWDTRSN 259

Query: 122 TLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEG 181
                 H  +     + C+ + P  +       AD  + LWDL+    +     S   E 
Sbjct: 260 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE- 318

Query: 182 KGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQ-------------IYCIENAHG 228
                    +WSPH+     ++  D  L  WD   + +             +  I   H 
Sbjct: 319 -----IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHT 373

Query: 229 QLVRDLDFNPNKQYYLASCGDDCKVKFW 256
             + D  +NPN+ + + S  +D  ++ W
Sbjct: 374 AKISDFSWNPNEPWVICSVSEDNIMQVW 401


>gi|5032027 retinoblastoma binding protein 4 isoform a [Homo
           sapiens]
          Length = 425

 Score = 71.2 bits (173), Expect = 1e-12
 Identities = 71/328 (21%), Positives = 127/328 (38%), Gaps = 45/328 (13%)

Query: 48  FDDENNIINKNVLLHQAGEIWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELES 107
           F   +  I   + ++  GE+      P +  ++ T   +T  S VL            + 
Sbjct: 108 FGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIAT---KTPSSDVLV----------FDY 154

Query: 108 GSHES-PDDSSSTAQTLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQE 166
             H S PD S      L L  H     +G    + W P   G  + +  D+ I LWD+  
Sbjct: 155 TKHPSKPDPSGECNPDLRLRGH-QKEGYG----LSWNPNLSGHLLSASDDHTICLWDISA 209

Query: 167 SSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRS--MSQIYCIE 224
              +  +  + ++            W   H     + A+D  L  WDTRS   S+     
Sbjct: 210 VPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSV 269

Query: 225 NAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSH 284
           +AH   V  L FNP  ++ LA+   D  V  WD RN+   + + E H   ++ V+++  +
Sbjct: 270 DAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHN 329

Query: 285 DQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQD---NVIA 341
           + ++ +  +D R+ + ++  I                      EE+S E  +D    ++ 
Sbjct: 330 ETILASSGTDRRLNVWDLSKI---------------------GEEQSPEDAEDGPPELLF 368

Query: 342 TYEEHEDSVYAVDWSSADPWLFASLSYD 369
            +  H   +    W+  +PW+  S+S D
Sbjct: 369 IHGGHTAKISDFSWNPNEPWVICSVSED 396



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 40/189 (21%), Positives = 84/189 (44%), Gaps = 39/189 (20%)

Query: 192 WSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENA------HGQLVRDLDFNPNKQYYLA 245
           W+P+ +   ++ ++D T+  WD  ++ +   + +A      H  +V D+ ++   +    
Sbjct: 185 WNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFG 244

Query: 246 SCGDDCKVKFWDTR--NVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMV 303
           S  DD K+  WDTR  N ++P  +++ H+  V  + +N   + ++ TGS+D  V L ++ 
Sbjct: 245 SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLR 304

Query: 304 SISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLF 363
           ++  +                               + ++E H+D ++ V WS  +  + 
Sbjct: 305 NLKLK-------------------------------LHSFESHKDEIFQVQWSPHNETIL 333

Query: 364 ASLSYDGRL 372
           AS   D RL
Sbjct: 334 ASSGTDRRL 342



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 42/208 (20%), Positives = 74/208 (35%), Gaps = 27/208 (12%)

Query: 67  IWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSS-----STAQ 121
           +W ISA P +  V+      T  + V+   + W +  E   GS    DD       + + 
Sbjct: 204 LWDISAVPKEGKVVDAKTIFTGHTAVVEDVS-WHLLHESLFGS--VADDQKLMIWDTRSN 260

Query: 122 TLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEG 181
                 H  +     + C+ + P  +       AD  + LWDL+    +     S   E 
Sbjct: 261 NTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDE- 319

Query: 182 KGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQ-------------IYCIENAHG 228
                    +WSPH+     ++  D  L  WD   + +             +  I   H 
Sbjct: 320 -----IFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHT 374

Query: 229 QLVRDLDFNPNKQYYLASCGDDCKVKFW 256
             + D  +NPN+ + + S  +D  ++ W
Sbjct: 375 AKISDFSWNPNEPWVICSVSEDNIMQVW 402


>gi|58331266 WD repeat domain 59 [Homo sapiens]
          Length = 974

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 47/187 (25%), Positives = 87/187 (46%), Gaps = 13/187 (6%)

Query: 151 IISLADNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLR 210
           + S  D +I +WD++++    V  S+ +  G  Q+K+         N   +AT++D  +R
Sbjct: 122 VTSSVDTYIYIWDIKDTRKPTVALSAVA--GASQVKWNK------KNANCLATSHDGDVR 173

Query: 211 GWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEE 270
            WD R  S       AH   +  LD++P+ ++ LA+   D  VKFWD R   + +  L  
Sbjct: 174 IWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHILATSSQDNSVKFWDYRQPRKYLNILPC 233

Query: 271 HSHWVWNVRYNHSHDQLVLTG----SSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHR 326
               VW  RY    + LV         ++ ++L N+  +++     +  DD + + +  +
Sbjct: 234 QVP-VWKARYTPFSNGLVTVMVPQLRRENSLLLWNVFDLNTPVHTFVGHDDVVLEFQWRK 292

Query: 327 SEEKSKE 333
            +E SK+
Sbjct: 293 QKEGSKD 299


>gi|4505731 peroxisomal biogenesis factor 7 [Homo sapiens]
          Length = 323

 Score = 58.9 bits (141), Expect = 7e-09
 Identities = 35/141 (24%), Positives = 64/141 (45%), Gaps = 7/141 (4%)

Query: 141 VWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQ 200
           +W P   G    +  D  + +WD++ +  + V+ +        Q +  S  W  ++    
Sbjct: 162 IWSPHIPGCFASASGDQTLRIWDVKAAGVRIVIPAH-------QAEILSCDWCKYNENLL 214

Query: 201 VATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRN 260
           V  A D +LRGWD R++ Q       H   +R + F+P     LASC  D  V+FW+   
Sbjct: 215 VTGAVDCSLRGWDLRNVRQPVFELLGHTYAIRRVKFSPFHASVLASCSYDFTVRFWNFSK 274

Query: 261 VTEPVKTLEEHSHWVWNVRYN 281
               ++T+E H+ +   + ++
Sbjct: 275 PDSLLETVEHHTEFTCGLDFS 295



 Score = 58.2 bits (139), Expect = 1e-08
 Identities = 51/219 (23%), Positives = 84/219 (38%), Gaps = 39/219 (17%)

Query: 156 DNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTR 215
           D  + LWD     S        S+         S  WSPH      + + D TLR WD +
Sbjct: 134 DQTVKLWDPTVGKSLCTFRGHESI-------IYSTIWSPHIPGCFASASGDQTLRIWDVK 186

Query: 216 SMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWV 275
           +   +  +  AH   +   D+    +  L +   DC ++ WD RNV +PV  L  H++ +
Sbjct: 187 AAG-VRIVIPAHQAEILSCDWCKYNENLLVTGAVDCSLRGWDLRNVRQPVFELLGHTYAI 245

Query: 276 WNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPL 335
             V+++  H  ++ + S D  V   N     S+P                          
Sbjct: 246 RRVKFSPFHASVLASCSYDFTVRFWNF----SKP-------------------------- 275

Query: 336 QDNVIATYEEHEDSVYAVDWSSADPWLFASLSYDGRLVI 374
            D+++ T E H +    +D+S   P   A  S+D  + I
Sbjct: 276 -DSLLETVEHHTEFTCGLDFSLQSPTQVADCSWDETIKI 313



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 36/143 (25%), Positives = 61/143 (42%), Gaps = 33/143 (23%)

Query: 233 DLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSH-DQLVLTG 291
           D+ ++ N ++ L +C  D  ++ WDT     P++  +EH+  V++V ++ +  +QLV++G
Sbjct: 72  DVTWSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSG 131

Query: 292 SSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVY 351
           S D  V                                K  +P     + T+  HE  +Y
Sbjct: 132 SWDQTV--------------------------------KLWDPTVGKSLCTFRGHESIIY 159

Query: 352 AVDWSSADPWLFASLSYDGRLVI 374
           +  WS   P  FAS S D  L I
Sbjct: 160 STIWSPHIPGCFASASGDQTLRI 182



 Score = 32.3 bits (72), Expect = 0.74
 Identities = 18/67 (26%), Positives = 30/67 (44%), Gaps = 1/67 (1%)

Query: 192 WSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGD-D 250
           WS ++    +  + D +L+ WDT   +    +   H Q V  +D++  +   L   G  D
Sbjct: 75  WSENNEHVLITCSGDGSLQLWDTAKAAGPLQVYKEHAQEVYSVDWSQTRGEQLVVSGSWD 134

Query: 251 CKVKFWD 257
             VK WD
Sbjct: 135 QTVKLWD 141



 Score = 32.3 bits (72), Expect = 0.74
 Identities = 18/74 (24%), Positives = 31/74 (41%)

Query: 191 RWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDD 250
           ++SP H     + + D T+R W+      +      H +    LDF+      +A C  D
Sbjct: 249 KFSPFHASVLASCSYDFTVRFWNFSKPDSLLETVEHHTEFTCGLDFSLQSPTQVADCSWD 308

Query: 251 CKVKFWDTRNVTEP 264
             +K +D   +T P
Sbjct: 309 ETIKIYDPACLTIP 322


>gi|14149696 SEC31 homolog B [Homo sapiens]
          Length = 1179

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 49/220 (22%), Positives = 90/220 (40%), Gaps = 39/220 (17%)

Query: 155 ADNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDT 214
           +D+ I +WDL   +    L S  S +    +K  S      H  +    +    +  WD 
Sbjct: 142 SDSEIFIWDLNNLNVPMTLGSK-SQQPPEDIKALSWNRQAQHILSSAHPSGKAVV--WDL 198

Query: 215 RSMSQIYCIENAHGQL-VRDLDFNPNKQYYLASCGDDCK---VKFWDTRNVTEPVKTLEE 270
           R    I  + +   ++    L ++P+    L  C +D +   ++ WD R  + P+K LE 
Sbjct: 199 RKNEPIIKVSDHSNRMHCSGLAWHPDIATQLVLCSEDDRLPVIQLWDLRFASSPLKVLES 258

Query: 271 HSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEK 330
           HS  + +V ++ +  +L+LT + DS+++  N+ S                      SE  
Sbjct: 259 HSRGILSVSWSQADAELLLTSAKDSQILCRNLGS----------------------SEVV 296

Query: 331 SKEPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSYDG 370
            K P Q +            + V W   DP +F++ S++G
Sbjct: 297 YKLPTQSS----------WCFDVQWCPRDPSVFSAASFNG 326



 Score = 35.4 bits (80), Expect = 0.088
 Identities = 38/167 (22%), Positives = 64/167 (38%), Gaps = 20/167 (11%)

Query: 227 HGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPV-------KTLEEHSHWVWNVR 279
           H   VR LD NP +   LAS   D ++  WD  N+  P+       +  E+     WN +
Sbjct: 120 HTGAVRALDLNPFQGNLLASGASDSEIFIWDLNNLNVPMTLGSKSQQPPEDIKALSWNRQ 179

Query: 280 YNHSHDQLVLTGSSDSRVILSN--MVSISSEP----FGHLVDDDDISDQEDHRSEEKSKE 333
             H       +G +    +  N  ++ +S          L    DI+ Q    SE+    
Sbjct: 180 AQHILSSAHPSGKAVVWDLRKNEPIIKVSDHSNRMHCSGLAWHPDIATQLVLCSEDDRLP 239

Query: 334 PLQ-------DNVIATYEEHEDSVYAVDWSSADPWLFASLSYDGRLV 373
            +Q        + +   E H   + +V WS AD  L  + + D +++
Sbjct: 240 VIQLWDLRFASSPLKVLESHSRGILSVSWSQADAELLLTSAKDSQIL 286


>gi|110815800 WD repeat domain 32 [Homo sapiens]
          Length = 559

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 33/108 (30%), Positives = 54/108 (50%), Gaps = 4/108 (3%)

Query: 192 WSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDC 251
           +SP  +   VA    T +  +D  S   I  +  AH   V ++ F  N+ +  A+C DD 
Sbjct: 176 YSPDGSVLTVA-CEQTEVLLFDPISSKHIKTLSEAHEDCVNNIRFLDNRLF--ATCSDDT 232

Query: 252 KVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVIL 299
            +  WD R +   V TL  H+ WV N+ Y+ ++ +L++T   D  VI+
Sbjct: 233 TIALWDLRKLNTKVCTLHGHTSWVKNIEYD-TNTRLLVTSGFDGNVII 279


>gi|24308452 WD repeat domain 85 [Homo sapiens]
          Length = 452

 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 43/164 (26%), Positives = 66/164 (40%), Gaps = 33/164 (20%)

Query: 205 NDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEP 264
           +D  LRGWDTR   +       H   V  +  +P++++ LA+   D  +  WDTRN+ +P
Sbjct: 216 DDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLWDTRNMKQP 275

Query: 265 VKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQED 324
           +         VW ++++  H  L+L     S   + N                       
Sbjct: 276 LADTPVQG-GVWRIKWHPFHHHLLLAACMHSGFKILNC---------------------- 312

Query: 325 HRSEEKSKEPLQDNVIATYEEHEDS-VYAVDWSSADPW-LFASL 366
               +K+ E  Q+  + T     DS VY  DWS    W LF SL
Sbjct: 313 ----QKAMEERQEATVLTSHTLPDSLVYGADWS----WLLFRSL 348


>gi|19913369 transducin beta-like 3 [Homo sapiens]
          Length = 808

 Score = 52.8 bits (125), Expect = 5e-07
 Identities = 70/272 (25%), Positives = 115/272 (42%), Gaps = 28/272 (10%)

Query: 61  LHQAGEIWHIS-ASPADRGVLTTCYNRTSDSKVLT-----CAAVWRMPKELESGSHESPD 114
           +++AG++  ++  S     V T C +R  +S ++T        +W +PK L S  + +PD
Sbjct: 405 MNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLS-KNTAPD 463

Query: 115 DSSST--AQTLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAV 172
           +      AQT +  CH       ++  V   P  D        D    LW L +     V
Sbjct: 464 NGPILLQAQTTQR-CH-----DKDINSVAIAP-NDKLLATGSQDRTAKLWALPQCQLLGV 516

Query: 173 LASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVR 232
              S    G   ++F     SP       A+A D T++ W  +  S +   E     +++
Sbjct: 517 F--SGHRRGLWCVQF-----SPMDQVLATASA-DGTIKLWALQDFSCLKTFEGHDASVLK 568

Query: 233 DLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGS 292
               +   Q  L S G D  VK W  +N  E V+TL+ H   VW +  +   D   LTG+
Sbjct: 569 VAFVSRGTQ--LLSSGSDGLVKLWTIKN-NECVRTLDAHEDKVWGLHCSRLDDH-ALTGA 624

Query: 293 SDSRVILSNMVSISSEPFGHLVDDDDISDQED 324
           SDSRVIL   V+ + +       ++ +  Q++
Sbjct: 625 SDSRVILWKDVTEAEQAEEQARQEEQVVRQQE 656



 Score = 30.0 bits (66), Expect = 3.7
 Identities = 15/55 (27%), Positives = 25/55 (45%), Gaps = 2/55 (3%)

Query: 204 ANDTTLRGWDTRSMSQIYCIE--NAHGQLVRDLDFNPNKQYYLASCGDDCKVKFW 256
           A D ++R W      Q+ C+   + H   V  +  +  K+ +L +   DC VK W
Sbjct: 395 AKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449


>gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens]
          Length = 446

 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 51/208 (24%), Positives = 85/208 (40%), Gaps = 26/208 (12%)

Query: 142 WEPMGDGKKIISLADNHILLWDLQESSSQAV-----LASSASLEGKGQLKFTSGRWSPHH 196
           W P   G+ +      +I LW   +  S  V     +  + S+E          +WSP  
Sbjct: 222 WSPRVTGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHTRSVEDL--------QWSPTE 273

Query: 197 NCTQVATANDTTLRGWDTRSMSQIYCI---ENAHGQLVRDLDFNPNKQYYLASCGDDCKV 253
           N    + + D ++R WD R+     C+     AH   V  + ++  ++ +L S GDD  +
Sbjct: 274 NTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWS-RREPFLLSGGDDGAL 332

Query: 254 KFWDTRNVT--EPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEP-F 310
           K WD R      PV T ++H   V +V + H  D  V   S     I    +++  +P  
Sbjct: 333 KIWDLRQFKSGSPVATFKQHVAPVTSVEW-HPQDSGVFAASGADHQITQWDLAVERDPEA 391

Query: 311 GHLVDDDDISDQED-----HRSEEKSKE 333
           G +  D  ++D        H+ E + KE
Sbjct: 392 GDVEADPGLADLPQQLLFVHQGETELKE 419



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 43/160 (26%), Positives = 64/160 (40%), Gaps = 34/160 (21%)

Query: 227 HGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQ 286
           H + V DL ++P +    ASC  D  ++ WD R        L   +          +HD 
Sbjct: 260 HTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPSKACMLTTAT----------AHDG 309

Query: 287 LVLTGSSDSRVILSNMVSIS-SEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEE 345
            V            N++S S  EPF     DD      D R + KS  P     +AT+++
Sbjct: 310 DV------------NVISWSRREPFLLSGGDDGALKIWDLR-QFKSGSP-----VATFKQ 351

Query: 346 HEDSVYAVDWSSADPWLFASLSYDGR-----LVINRVPRA 380
           H   V +V+W   D  +FA+   D +     L + R P A
Sbjct: 352 HVAPVTSVEWHPQDSGVFAASGADHQITQWDLAVERDPEA 391


>gi|217330644 WD repeat domain 12 protein [Homo sapiens]
          Length = 423

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 46/170 (27%), Positives = 80/170 (47%), Gaps = 16/170 (9%)

Query: 132 TAHGNMACVVWEPMGDGKKIISLADNH-ILLWDLQESSSQAVLASSASLEGKGQLKFTSG 190
           T  G+M  V      D ++I S + +H I +WD++  S ++ L         G   F   
Sbjct: 252 TLSGHMEAVSSVLWSDAEEICSASWDHTIRVWDVESGSLKSTLT--------GNKVFNCI 303

Query: 191 RWSPHHNCTQVATAN-DTTLRGWDTRSM--SQIYCIENAHGQLVRDLDFNPNKQYYLASC 247
            +SP   C ++A+ + D  +R WD R+   S +     +H   V  + ++P  +  L S 
Sbjct: 304 SYSPL--CKRLASGSTDRHIRLWDPRTKDGSLVSLSLTSHTGWVTSVKWSPTHEQQLISG 361

Query: 248 GDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRV 297
             D  VK WDTR+   P+  L  H   V +V +  +   L+L+G +D+++
Sbjct: 362 SLDNIVKLWDTRSCKAPLYDLAAHEDKVLSVDWTDT--GLLLSGGADNKL 409



 Score = 43.5 bits (101), Expect = 3e-04
 Identities = 47/169 (27%), Positives = 72/169 (42%), Gaps = 38/169 (22%)

Query: 206 DTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPV 265
           D T+R WD  S S    +     ++   + ++P  +  LAS   D  ++ WD R     +
Sbjct: 277 DHTIRVWDVESGSLKSTLTG--NKVFNCISYSPLCKR-LASGSTDRHIRLWDPRTKDGSL 333

Query: 266 KTLEEHSH--WVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQE 323
            +L   SH  WV +V+++ +H+Q +++GS D+ V L                        
Sbjct: 334 VSLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLW----------------------- 370

Query: 324 DHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSYDGRL 372
           D RS    K PL D        HED V +VDW+  D  L  S   D +L
Sbjct: 371 DTRS---CKAPLYD-----LAAHEDKVLSVDWT--DTGLLLSGGADNKL 409


>gi|13129110 WD repeat domain 77 [Homo sapiens]
          Length = 342

 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 13/235 (5%)

Query: 64  AGEIWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSSSTAQTL 123
           A E+W +  +     ++ + + +     +++  +V     +  SGS +        AQ +
Sbjct: 102 AVELWELDENET---LIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 158

Query: 124 ELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKG 183
            L  +  + A   + CV   P  D   +    DN ILLWD +     + +  SA     G
Sbjct: 159 VLSSYRAHAAQ--VTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIGCSAP----G 212

Query: 184 QLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYY 243
            L  TS  W P  +   V    + T+   DT+S S +      H Q V  L F+P+   +
Sbjct: 213 YLP-TSLAWHPQQSEVFVFGDENGTVSLVDTKSTSCVLS-SAVHSQCVTGLVFSPHSVPF 270

Query: 244 LASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVI 298
           LAS  +DC +   D+ +++E  ++ + H  +V +  ++  +  L+ T   D +V+
Sbjct: 271 LASLSEDCSLAVLDS-SLSELFRS-QAHRDFVRDATWSPLNHSLLTTVGWDHQVV 323



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 51/267 (19%), Positives = 103/267 (38%), Gaps = 20/267 (7%)

Query: 124 ELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKG 183
           E  C         +A + W  +G+   +++     + LW+L E+ +  +++     E   
Sbjct: 70  EGFCSAGVQTEAGVADLTW--VGERGILVASDSGAVELWELDENET-LIVSKFCKYEHDD 126

Query: 184 QLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYY 243
            +   S   S       V+ + D  ++ WD  +   +     AH   V  +  +P+K   
Sbjct: 127 IVSTVSVLSS---GTQAVSGSKDICIKVWDL-AQQVVLSSYRAHAAQVTCVAASPHKDSV 182

Query: 244 LASCGDDCKVKFWDTRNVTEPVKTL--EEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSN 301
             SC +D ++  WDTR   +P   +      +   ++ ++    ++ + G  +  V L +
Sbjct: 183 FLSCSEDNRILLWDTR-CPKPASQIGCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD 241

Query: 302 MVSIS--------SEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATY--EEHEDSVY 351
             S S        S+    LV            SE+ S   L  ++   +  + H D V 
Sbjct: 242 TKSTSCVLSSAVHSQCVTGLVFSPHSVPFLASLSEDCSLAVLDSSLSELFRSQAHRDFVR 301

Query: 352 AVDWSSADPWLFASLSYDGRLVINRVP 378
              WS  +  L  ++ +D ++V + VP
Sbjct: 302 DATWSPLNHSLLTTVGWDHQVVHHVVP 328


>gi|38605733 nucleoporin 43kDa [Homo sapiens]
          Length = 380

 Score = 48.1 bits (113), Expect = 1e-05
 Identities = 31/100 (31%), Positives = 49/100 (49%), Gaps = 6/100 (6%)

Query: 200 QVATANDT-TLRGWDTRSM----SQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVK 254
           ++ T N    L+ WD R      SQI  +      L   +D +PN+Q+ +A+ G D  + 
Sbjct: 185 EILTVNSIGQLKIWDFRQQGNEPSQILSLTGDRVPL-HCVDRHPNQQHVVATGGQDGMLS 243

Query: 255 FWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSD 294
            WD R  T PV  L+ H   +W V ++ S+ + + T S D
Sbjct: 244 IWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSED 283



 Score = 30.8 bits (68), Expect = 2.2
 Identities = 17/58 (29%), Positives = 28/58 (48%), Gaps = 1/58 (1%)

Query: 201 VATAN-DTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWD 257
           VAT   D  L  WD R  +    +  AH   + ++ F+P+   +L +C +D  +  WD
Sbjct: 233 VATGGQDGMLSIWDVRQGTMPVSLLKAHEAEMWEVHFHPSNPEHLFTCSEDGSLWHWD 290


>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
           sapiens]
          Length = 421

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 42/170 (24%), Positives = 69/170 (40%), Gaps = 35/170 (20%)

Query: 205 NDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEP 264
           N+  ++ WD  +   +  + + H ++VRDL F P+    L S   D  ++ WD ++    
Sbjct: 148 NNGRIKIWDVYTGKLLLNLVD-HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNM 206

Query: 265 VKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQED 324
           +K L  H +WV++  ++     L   G+S + V L NM   +                  
Sbjct: 207 MKVLRGHQNWVYSCAFSPDSSMLCSVGASKA-VFLWNMDKYT------------------ 247

Query: 325 HRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSYDGRLVI 374
                         +I   E H   V A D+ S D  L A+ SYD R+ I
Sbjct: 248 --------------MIRKLEGHHHDVVACDF-SPDGALLATASYDTRVYI 282



 Score = 37.7 bits (86), Expect = 0.018
 Identities = 32/109 (29%), Positives = 49/109 (44%), Gaps = 5/109 (4%)

Query: 192 WSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDC 251
           ++P  +   V+ + D TLR WD +    +  +   H   V    F+P+    L S G   
Sbjct: 178 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSS-MLCSVGASK 236

Query: 252 KVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHD-QLVLTGSSDSRVIL 299
            V  W+    T  ++ LE H H V  V  + S D  L+ T S D+RV +
Sbjct: 237 AVFLWNMDKYT-MIRKLEGHHHDV--VACDFSPDGALLATASYDTRVYI 282


>gi|109627650 coronin 6 [Homo sapiens]
          Length = 472

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 27/95 (28%), Positives = 48/95 (50%), Gaps = 6/95 (6%)

Query: 214 TRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDT------RNVTEPVKT 267
           T  + + Y +   H   V D+D+ P+    +AS  DD  +  W        RN+TEP+ T
Sbjct: 67  TGRVDKNYPLVTGHTAPVLDIDWCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIIT 126

Query: 268 LEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNM 302
           LE HS  V  + ++ +   ++L+   D+ +I+ N+
Sbjct: 127 LEGHSKRVGILSWHPTARNVLLSAGGDNVIIIWNV 161



 Score = 34.3 bits (77), Expect = 0.20
 Identities = 28/127 (22%), Positives = 54/127 (42%), Gaps = 9/127 (7%)

Query: 192 WSPHHNCTQVATANDTTLRGWD------TRSMSQIYCIENAHGQLVRDLDFNPNKQYYLA 245
           W PH++    + ++DTT+  W        R++++       H + V  L ++P  +  L 
Sbjct: 89  WCPHNDNVIASASDDTTIMVWQIPDYTPMRNITEPIITLEGHSKRVGILSWHPTARNVLL 148

Query: 246 SCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDS--RVILSNMV 303
           S G D  +  W+       +   + H   + +V +N S+  L+ T   D   R+I     
Sbjct: 149 SAGGDNVIIIWNVGTGEVLLSLDDMHPDVIHSVCWN-SNGSLLATTCKDKTLRIIDPRKG 207

Query: 304 SISSEPF 310
            + +E F
Sbjct: 208 QVVAERF 214


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 45/166 (27%), Positives = 76/166 (45%), Gaps = 14/166 (8%)

Query: 153 SLADNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLRGW 212
           S AD  I++W   +   +  L           L+ +   WS   +   V+ ++D TL+ W
Sbjct: 59  SSADRLIIIWGAYDGKYEKTLYGH-------NLEISDVAWSSDSS-RLVSASDDKTLKLW 110

Query: 213 DTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHS 272
           D RS   +  ++  H   V   +FNP     ++   D+  VK W+ +   + +KTL  HS
Sbjct: 111 DVRSGKCLKTLK-GHSNYVFCCNFNPPSNLIISGSFDE-TVKIWEVK-TGKCLKTLSAHS 167

Query: 273 HWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDD 318
             V  V +N S   L+++GS D    + +  + S +    LVDDD+
Sbjct: 168 DPVSAVHFNCS-GSLIVSGSYDGLCRIWD--AASGQCLKTLVDDDN 210



 Score = 32.0 bits (71), Expect = 0.97
 Identities = 29/113 (25%), Positives = 52/113 (46%), Gaps = 7/113 (6%)

Query: 195 HHNCTQ---VATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDC 251
           H NC+    V+ + D   R WD  S   +  + +     V  + F+PN +Y L +  D+ 
Sbjct: 174 HFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDN- 232

Query: 252 KVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHS--HDQLVLTGSSDSRVILSNM 302
            +K WD       +KT   H +  + +  N S    + +++GS D+ V + N+
Sbjct: 233 TLKLWDYSR-GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 284


>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
           sapiens]
          Length = 275

 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 39/148 (26%), Positives = 59/148 (39%), Gaps = 34/148 (22%)

Query: 227 HGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQ 286
           H ++VRDL F P+    L S   D  ++ WD ++    +K L  H +WV++  ++     
Sbjct: 23  HTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSSM 82

Query: 287 LVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEH 346
           L   G+S + V L NM   +                                +I   E H
Sbjct: 83  LCSVGASKA-VFLWNMDKYT--------------------------------MIRKLEGH 109

Query: 347 EDSVYAVDWSSADPWLFASLSYDGRLVI 374
              V A D+ S D  L A+ SYD R+ I
Sbjct: 110 HHDVVACDF-SPDGALLATASYDTRVYI 136



 Score = 37.7 bits (86), Expect = 0.018
 Identities = 32/109 (29%), Positives = 49/109 (44%), Gaps = 5/109 (4%)

Query: 192 WSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDC 251
           ++P  +   V+ + D TLR WD +    +  +   H   V    F+P+    L S G   
Sbjct: 32  FAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLRGHQNWVYSCAFSPDSS-MLCSVGASK 90

Query: 252 KVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHD-QLVLTGSSDSRVIL 299
            V  W+    T  ++ LE H H V  V  + S D  L+ T S D+RV +
Sbjct: 91  AVFLWNMDKYT-MIRKLEGHHHDV--VACDFSPDGALLATASYDTRVYI 136


>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
          Length = 1298

 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 31/130 (23%), Positives = 57/130 (43%), Gaps = 14/130 (10%)

Query: 140 VVWEPMGDGKKIISLADNHILLWDLQESSSQAVL-ASSASLEGKGQLKFTSGRWSPHHNC 198
           V W P+ +G       D  + +WD  + +   +L   +A + G          W+     
Sbjct: 548 VKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGL--------MWNTEIPY 599

Query: 199 TQVATANDTTLRGWDTRSMSQIYCIENA--HGQLVRDLDFNPNKQYYLASCGDDCKVKFW 256
             ++ + D T++ WDTR  +   C++    HG  V  L  +P++ + +ASC  D  V+ W
Sbjct: 600 LLISGSWDYTIKVWDTREGT---CVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 656

Query: 257 DTRNVTEPVK 266
               +  PV+
Sbjct: 657 SLTALVTPVQ 666



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 32/157 (20%), Positives = 70/157 (44%), Gaps = 16/157 (10%)

Query: 227 HGQLVRDLDFNPNKQYYLASCGDDCKVK-FWDTRNVTEPVKTLEEHSHWVWNVRYNHSHD 285
           H   V   D++ N +  +A+  +D  V+ ++   +  +P+K    H+  V++V+++   +
Sbjct: 496 HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLRE 555

Query: 286 QLVLTGSSDSRVIL--------SNMVSISSEPFGHLVDDDD-----ISDQEDHRSEEKSK 332
            ++ +GS D  V +         N+++  + P   L+ + +     IS   D+    K  
Sbjct: 556 GILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTI--KVW 613

Query: 333 EPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSYD 369
           +  +   + T  +H   VY +    + P+  AS S D
Sbjct: 614 DTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRD 650



 Score = 30.0 bits (66), Expect = 3.7
 Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 4/105 (3%)

Query: 192 WSPHHNCTQVATANDTTLRGWDTRSMS-QIYCIENAHGQLVRDLDFNPNKQYYLASCGDD 250
           WS ++         DT +R +   + S Q   + + H   V  + ++P ++  L S  DD
Sbjct: 505 WSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDD 564

Query: 251 CKVKFWD-TRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSD 294
             V+ WD T++    +  L  H+  V  + +N     L+++GS D
Sbjct: 565 GTVRIWDYTQDAC--INILNGHTAPVRGLMWNTEIPYLLISGSWD 607



 Score = 29.3 bits (64), Expect = 6.3
 Identities = 18/53 (33%), Positives = 25/53 (47%), Gaps = 7/53 (13%)

Query: 322 QEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSYDGRLVI 374
           Q DHR  E           A   EH+ ++ A+ W   +P LFAS S D  ++I
Sbjct: 41  QLDHRYNEFKLH-------AIMSEHKKTITAISWCPHNPDLFASGSTDNLVII 86



 Score = 29.3 bits (64), Expect = 6.3
 Identities = 35/186 (18%), Positives = 68/186 (36%), Gaps = 13/186 (6%)

Query: 201 VATAN-DTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTR 259
           +ATA+ D T++ WD  +++ +Y      G ++  L + P     +A          W+ +
Sbjct: 385 LATASFDGTIKVWDINTLTAVYTSPGNEG-VIYSLSWAPGGLNCIAGGTSRNGAFIWNVQ 443

Query: 260 NVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLV----- 314
                 +  E  ++ ++ + ++H   + + T SSD   I+  +       + H       
Sbjct: 444 KGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFGC 503

Query: 315 ------DDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSY 368
                  D   +  ED            D  +  +  H   V+ V WS     +  S S 
Sbjct: 504 DWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSD 563

Query: 369 DGRLVI 374
           DG + I
Sbjct: 564 DGTVRI 569


>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
          Length = 1322

 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 31/130 (23%), Positives = 57/130 (43%), Gaps = 14/130 (10%)

Query: 140 VVWEPMGDGKKIISLADNHILLWDLQESSSQAVL-ASSASLEGKGQLKFTSGRWSPHHNC 198
           V W P+ +G       D  + +WD  + +   +L   +A + G          W+     
Sbjct: 572 VKWSPLREGILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGL--------MWNTEIPY 623

Query: 199 TQVATANDTTLRGWDTRSMSQIYCIENA--HGQLVRDLDFNPNKQYYLASCGDDCKVKFW 256
             ++ + D T++ WDTR  +   C++    HG  V  L  +P++ + +ASC  D  V+ W
Sbjct: 624 LLISGSWDYTIKVWDTREGT---CVDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLW 680

Query: 257 DTRNVTEPVK 266
               +  PV+
Sbjct: 681 SLTALVTPVQ 690



 Score = 30.4 bits (67), Expect = 2.8
 Identities = 32/157 (20%), Positives = 70/157 (44%), Gaps = 16/157 (10%)

Query: 227 HGQLVRDLDFNPNKQYYLASCGDDCKVK-FWDTRNVTEPVKTLEEHSHWVWNVRYNHSHD 285
           H   V   D++ N +  +A+  +D  V+ ++   +  +P+K    H+  V++V+++   +
Sbjct: 520 HPAAVFGCDWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLRE 579

Query: 286 QLVLTGSSDSRVIL--------SNMVSISSEPFGHLVDDDD-----ISDQEDHRSEEKSK 332
            ++ +GS D  V +         N+++  + P   L+ + +     IS   D+    K  
Sbjct: 580 GILCSGSDDGTVRIWDYTQDACINILNGHTAPVRGLMWNTEIPYLLISGSWDYTI--KVW 637

Query: 333 EPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSYD 369
           +  +   + T  +H   VY +    + P+  AS S D
Sbjct: 638 DTREGTCVDTVYDHGADVYGLTCHPSRPFTMASCSRD 674



 Score = 30.0 bits (66), Expect = 3.7
 Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 4/105 (3%)

Query: 192 WSPHHNCTQVATANDTTLRGWDTRSMS-QIYCIENAHGQLVRDLDFNPNKQYYLASCGDD 250
           WS ++         DT +R +   + S Q   + + H   V  + ++P ++  L S  DD
Sbjct: 529 WSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDD 588

Query: 251 CKVKFWD-TRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSD 294
             V+ WD T++    +  L  H+  V  + +N     L+++GS D
Sbjct: 589 GTVRIWDYTQDAC--INILNGHTAPVRGLMWNTEIPYLLISGSWD 631



 Score = 29.3 bits (64), Expect = 6.3
 Identities = 18/53 (33%), Positives = 25/53 (47%), Gaps = 7/53 (13%)

Query: 322 QEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSYDGRLVI 374
           Q DHR  E           A   EH+ ++ A+ W   +P LFAS S D  ++I
Sbjct: 65  QLDHRYNEFKLH-------AIMSEHKKTITAISWCPHNPDLFASGSTDNLVII 110



 Score = 29.3 bits (64), Expect = 6.3
 Identities = 35/186 (18%), Positives = 68/186 (36%), Gaps = 13/186 (6%)

Query: 201 VATAN-DTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTR 259
           +ATA+ D T++ WD  +++ +Y      G ++  L + P     +A          W+ +
Sbjct: 409 LATASFDGTIKVWDINTLTAVYTSPGNEG-VIYSLSWAPGGLNCIAGGTSRNGAFIWNVQ 467

Query: 260 NVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLV----- 314
                 +  E  ++ ++ + ++H   + + T SSD   I+  +       + H       
Sbjct: 468 KGKIIQRFNEHGTNGIFCIAWSHKDSKRIATCSSDGFCIIRTIDGKVLHKYKHPAAVFGC 527

Query: 315 ------DDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSY 368
                  D   +  ED            D  +  +  H   V+ V WS     +  S S 
Sbjct: 528 DWSQNNKDMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSD 587

Query: 369 DGRLVI 374
           DG + I
Sbjct: 588 DGTVRI 593


>gi|14149987 WD repeat domain 24 [Homo sapiens]
          Length = 790

 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 28/109 (25%), Positives = 46/109 (42%), Gaps = 7/109 (6%)

Query: 192 WSPHHNCTQVATANDTTLRGWD--TRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGD 249
           W P           D  ++ WD  T    +++C++      V  + + P  +++LA+C  
Sbjct: 215 WHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIAS--VARVKWRPECRHHLATCSM 272

Query: 250 --DCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHD-QLVLTGSSDS 295
             D  +  WD R    P    EEH      + + H HD   +L+GS DS
Sbjct: 273 MVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFLLSGSKDS 321



 Score = 32.0 bits (71), Expect = 0.97
 Identities = 34/178 (19%), Positives = 67/178 (37%), Gaps = 21/178 (11%)

Query: 136 NMAC--VVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWS 193
           N++C  VVW  M +     +  +  ++ W+L   S             K    FT  + +
Sbjct: 74  NLSCADVVWHQMDENLLATAATNGVVVTWNLGRPS-----------RNKQDQLFTEHKRT 122

Query: 194 PHHNCTQVATAN-------DTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLAS 246
            +  C     A+       D  ++ +D R    +    +   + VRD+ F+    +  AS
Sbjct: 123 VNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTF-SGQSESVRDVQFSIRDYFTFAS 181

Query: 247 CGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVS 304
             ++  V+ WD R      +    H+  V+   ++      + TG  D  V + +M +
Sbjct: 182 TFENGNVQLWDIRRPDRCERMFTAHNGPVFCCDWHPEDRGWLATGGRDKMVKVWDMTT 239


>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
          Length = 404

 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 25/92 (27%), Positives = 44/92 (47%), Gaps = 8/92 (8%)

Query: 192 WSPHH------NCTQVATA-NDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYL 244
           W+ HH      +C  +AT  ND  ++ W+ ++   +  + + H  +VRDL F P+    L
Sbjct: 111 WARHHPQVPDVSCLVLATGLNDGQIKIWEVQTGLLLLNL-SGHQDVVRDLSFTPSGSLIL 169

Query: 245 ASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVW 276
            S   D  ++ WD     + ++ L  H  WV+
Sbjct: 170 VSASRDKTLRIWDLNKHGKQIQVLSGHLQWVY 201



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 41/172 (23%), Positives = 72/172 (41%), Gaps = 16/172 (9%)

Query: 154 LADNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLRGWD 213
           L D  I +W++Q  +   +L  S   +    L FT     P  +   V+ + D TLR WD
Sbjct: 130 LNDGQIKIWEVQ--TGLLLLNLSGHQDVVRDLSFT-----PSGSLILVSASRDKTLRIWD 182

Query: 214 TRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSH 273
                +   + + H Q V     +P+     ++ G+   V  W  R+ T  ++ LE H  
Sbjct: 183 LNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEK-SVFLWSMRSYT-LIRKLEGHQS 240

Query: 274 WVWNVRYNHSHDQLVLTGSSDSRVIL------SNMVSISSEPFGHLVDDDDI 319
            V +  ++     L++T S D+ VI+        + S+        +DD D+
Sbjct: 241 SVVSCDFS-PDSALLVTASYDTNVIMWDPYTGERLRSLHHTQVDPAMDDSDV 291


>gi|78482617 general transcription factor IIIC, polypeptide 2, beta
           110kDa [Homo sapiens]
          Length = 911

 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 21/58 (36%), Positives = 31/58 (53%), Gaps = 2/58 (3%)

Query: 226 AHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEE--HSHWVWNVRYN 281
           AH Q VR L +     ++L S G D K+KFWD R   EP+ +++    +   W + YN
Sbjct: 611 AHDQAVRTLQWCKANSHFLVSAGSDRKIKFWDLRRPYEPINSIKRFLSTELAWLLPYN 668


>gi|4504205 general transcription factor IIIC, polypeptide 2, beta
           110kDa [Homo sapiens]
          Length = 911

 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 21/58 (36%), Positives = 31/58 (53%), Gaps = 2/58 (3%)

Query: 226 AHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEE--HSHWVWNVRYN 281
           AH Q VR L +     ++L S G D K+KFWD R   EP+ +++    +   W + YN
Sbjct: 611 AHDQAVRTLQWCKANSHFLVSAGSDRKIKFWDLRRPYEPINSIKRFLSTELAWLLPYN 668


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 46/142 (32%), Positives = 67/142 (47%), Gaps = 19/142 (13%)

Query: 140 VVWEPMGDGKKIISLADN-HILLWDLQESSSQAVLASSASLEGKGQLKFTSG-RWSPHH- 196
           + W P  DG+K+ S   N  ILLWD   S+ + V  + A     G  K+ +G  W P H 
Sbjct: 162 ISWSP--DGRKLASGCKNGQILLWD--PSTGKQVGRTLA-----GHSKWITGLSWEPLHA 212

Query: 197 --NCTQVATAN-DTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKV 253
              C  VA+++ D ++R WDT +  +   I   H Q V  L +  +   Y AS   D  +
Sbjct: 213 NPECRYVASSSKDGSVRIWDTTA-GRCERILTGHTQSVTCLRWGGDGLLYSAS--QDRTI 269

Query: 254 KFWDTRNVTEPVKTLEEHSHWV 275
           K W   +     +TL+ H HWV
Sbjct: 270 KVWRAHDGVL-CRTLQGHGHWV 290



 Score = 37.0 bits (84), Expect = 0.030
 Identities = 31/132 (23%), Positives = 59/132 (44%), Gaps = 8/132 (6%)

Query: 170 QAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQ 229
           +AV   ++SLEG  +    S  +SP       + + DTT+R WD  + +  +  +  H  
Sbjct: 101 RAVTRCTSSLEGHSEAVI-SVAFSPTGKYL-ASGSGDTTVRFWDLSTETPHFTCKG-HRH 157

Query: 230 LVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWV----WNVRYNHSHD 285
            V  + ++P+ +   + C +  ++  WD     +  +TL  HS W+    W   + +   
Sbjct: 158 WVLSISWSPDGRKLASGCKNG-QILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPEC 216

Query: 286 QLVLTGSSDSRV 297
           + V + S D  V
Sbjct: 217 RYVASSSKDGSV 228


>gi|4502477 beta-transducin repeat containing protein isoform 2
           [Homo sapiens]
          Length = 569

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 45/178 (25%), Positives = 78/178 (43%), Gaps = 23/178 (12%)

Query: 125 LLCHLDNTAH-GNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKG 183
           L C    T H G++ C+ ++   +   I   +D+ + +WD+        L      E   
Sbjct: 297 LECKRILTGHTGSVLCLQYD---ERVIITGSSDSTVRVWDVNTGEMLNTLIHHC--EAVL 351

Query: 184 QLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYC--IENAHGQLVRDLDFNPNKQ 241
            L+F +G          V  + D ++  WD  S + I    +   H   V  +DF+    
Sbjct: 352 HLRFNNGM--------MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 401

Query: 242 YYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVIL 299
            Y+ S   D  +K W+T +  E V+TL  H   +  ++Y    D+LV++GSSD+ + L
Sbjct: 402 -YIVSASGDRTIKVWNT-STCEFVRTLNGHKRGIACLQYR---DRLVVSGSSDNTIRL 454



 Score = 29.3 bits (64), Expect = 6.3
 Identities = 17/48 (35%), Positives = 29/48 (60%), Gaps = 4/48 (8%)

Query: 250 DCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRV 297
           D  +K WD +N  E  + L  H+  V  ++Y+   +++++TGSSDS V
Sbjct: 286 DNTIKIWD-KNTLECKRILTGHTGSVLCLQYD---ERVIITGSSDSTV 329


>gi|16117783 beta-transducin repeat containing protein isoform 1
           [Homo sapiens]
          Length = 605

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 45/178 (25%), Positives = 78/178 (43%), Gaps = 23/178 (12%)

Query: 125 LLCHLDNTAH-GNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKG 183
           L C    T H G++ C+ ++   +   I   +D+ + +WD+        L      E   
Sbjct: 333 LECKRILTGHTGSVLCLQYD---ERVIITGSSDSTVRVWDVNTGEMLNTLIHHC--EAVL 387

Query: 184 QLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYC--IENAHGQLVRDLDFNPNKQ 241
            L+F +G          V  + D ++  WD  S + I    +   H   V  +DF+    
Sbjct: 388 HLRFNNGM--------MVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDK-- 437

Query: 242 YYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVIL 299
            Y+ S   D  +K W+T +  E V+TL  H   +  ++Y    D+LV++GSSD+ + L
Sbjct: 438 -YIVSASGDRTIKVWNT-STCEFVRTLNGHKRGIACLQYR---DRLVVSGSSDNTIRL 490



 Score = 29.3 bits (64), Expect = 6.3
 Identities = 17/48 (35%), Positives = 29/48 (60%), Gaps = 4/48 (8%)

Query: 250 DCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRV 297
           D  +K WD +N  E  + L  H+  V  ++Y+   +++++TGSSDS V
Sbjct: 322 DNTIKIWD-KNTLECKRILTGHTGSVLCLQYD---ERVIITGSSDSTV 365


>gi|4757988 WD repeat domain 39 [Homo sapiens]
          Length = 339

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 57/280 (20%), Positives = 102/280 (36%), Gaps = 51/280 (18%)

Query: 140 VVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCT 199
           V W P G+     S  D    +W   +   + V     +LEG  + +  S  W+P  N  
Sbjct: 67  VAWSPCGNYLASASF-DATTCIWKKNQDDFECV----TTLEGH-ENEVKSVAWAPSGNLL 120

Query: 200 QVATANDTTLRGWDTRSMSQIYCIE--NAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWD 257
              +  D ++  W+     +  C+   N+H Q V+ + ++P+++   ++  DD    + +
Sbjct: 121 ATCS-RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYRE 179

Query: 258 TRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVIL----------SNMVSISS 307
             +      TLE H   VW++ ++ S  +  L   SD R +             +    S
Sbjct: 180 EEDDWVCCATLEGHESTVWSLAFDPSGQR--LASCSDDRTVRIWRQYLPGNEQGVACSGS 237

Query: 308 EPFGHLV----------------------------DDDDISDQEDHRSEEKSKEPLQDNV 339
           +P    +                            DD     QED  S+   ++P     
Sbjct: 238 DPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSD--PQQPTFSLT 295

Query: 340 IATYEEHEDSVYAVDWSSADPWLFASLSYDGRLVINRVPR 379
              ++ H   V  V W+  +P L AS S DG +   +  R
Sbjct: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQR 335


>gi|7656991 coronin, actin binding protein, 1C isoform 1 [Homo
           sapiens]
          Length = 474

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 26/82 (31%), Positives = 43/82 (52%), Gaps = 6/82 (7%)

Query: 227 HGQLVRDLDFNPNKQYYLASCGDDCKVKFWD------TRNVTEPVKTLEEHSHWVWNVRY 280
           H   V D+D+ P+    +AS  +DC V  W       T ++TEPV  LE HS  V  V +
Sbjct: 79  HTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAW 138

Query: 281 NHSHDQLVLTGSSDSRVILSNM 302
           + +   ++L+   D+ +I+ N+
Sbjct: 139 HPTARNVLLSAGCDNAIIIWNV 160



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 27/112 (24%), Positives = 50/112 (44%), Gaps = 7/112 (6%)

Query: 192 WSPHHNCTQVATANDTTLRGWD------TRSMSQIYCIENAHGQLVRDLDFNPNKQYYLA 245
           W PH++    + + D T+  W       T S+++   I   H + V  + ++P  +  L 
Sbjct: 88  WCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLL 147

Query: 246 SCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRV 297
           S G D  +  W+       +   + HS  ++NV +N  +  L+ T S D +V
Sbjct: 148 SAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNR-NGSLICTASKDKKV 198


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.130    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,753,006
Number of Sequences: 37866
Number of extensions: 637475
Number of successful extensions: 2828
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 122
Number of HSP's that attempted gapping in prelim test: 2380
Number of HSP's gapped (non-prelim): 445
length of query: 387
length of database: 18,247,518
effective HSP length: 104
effective length of query: 283
effective length of database: 14,309,454
effective search space: 4049575482
effective search space used: 4049575482
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.