Search of human proteins with 4506967

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506967 v-ski sarcoma viral oncogene homolog [Homo sapiens]
         (728 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506967 v-ski sarcoma viral oncogene homolog [Homo sapiens]       1454   0.0  
gi|223029422 SKI-like isoform 3 [Homo sapiens]                        426   e-119
gi|223029418 SKI-like isoform 1 [Homo sapiens]                        426   e-119
gi|223029420 SKI-like isoform 2 [Homo sapiens]                        365   e-100
gi|239757043 PREDICTED: functional smad suppressing element 18 [...   132   1e-30
gi|239751555 PREDICTED: functional smad suppressing element 18 [...   132   1e-30
gi|239746067 PREDICTED: functional smad suppressing element 18 [...   132   1e-30
gi|73476377 LBXCOR1 homolog [Homo sapiens]                            125   1e-28
gi|4505101 microtubule-associated protein 7 [Homo sapiens]             64   4e-10
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi...    63   1e-09
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap...    62   1e-09
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C...    62   1e-09
gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo sapi...    62   1e-09
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                    59   2e-08
gi|115648142 centrosomal protein 164kDa [Homo sapiens]                 58   3e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    58   4e-08
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    57   5e-08
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    57   5e-08
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         57   8e-08
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    56   1e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        56   1e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        56   1e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         56   1e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         56   1e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         56   1e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         56   1e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         56   1e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         56   1e-07
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    55   2e-07
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    55   2e-07

>gi|4506967 v-ski sarcoma viral oncogene homolog [Homo sapiens]
          Length = 728

 Score = 1454 bits (3765), Expect = 0.0
 Identities = 728/728 (100%), Positives = 728/728 (100%)

Query: 1   MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAV 60
           MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAV
Sbjct: 1   MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAV 60

Query: 61  PAPVPAATEPPPVLHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKR 120
           PAPVPAATEPPPVLHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKR
Sbjct: 61  PAPVPAATEPPPVLHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKR 120

Query: 121 LCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKT 180
           LCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKT
Sbjct: 121 LCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKT 180

Query: 181 DAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSP 240
           DAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSP
Sbjct: 181 DAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSP 240

Query: 241 SAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARL 300
           SAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARL
Sbjct: 241 SAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARL 300

Query: 301 GRCLDDVKEKFDYGNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLA 360
           GRCLDDVKEKFDYGNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLA
Sbjct: 301 GRCLDDVKEKFDYGNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLA 360

Query: 361 GSSNKSLGCVHPRQRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVA 420
           GSSNKSLGCVHPRQRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVA
Sbjct: 361 GSSNKSLGCVHPRQRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVA 420

Query: 421 LAPPAQQKVVSSPPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDS 480
           LAPPAQQKVVSSPPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDS
Sbjct: 421 LAPPAQQKVVSSPPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDS 480

Query: 481 EAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEA 540
           EAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEA
Sbjct: 481 EAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEA 540

Query: 541 ELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKE 600
           ELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKE
Sbjct: 541 ELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKE 600

Query: 601 KLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLR 660
           KLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLR
Sbjct: 601 KLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLR 660

Query: 661 AKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGS 720
           AKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGS
Sbjct: 661 AKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGS 720

Query: 721 EGAAELEP 728
           EGAAELEP
Sbjct: 721 EGAAELEP 728


>gi|223029422 SKI-like isoform 3 [Homo sapiens]
          Length = 664

 Score =  426 bits (1095), Expect = e-119
 Identities = 262/698 (37%), Positives = 384/698 (55%), Gaps = 107/698 (15%)

Query: 14  HPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPV 73
           +P L+ TL QFHLSS SSLGGPAAFSAR +QE+                         P 
Sbjct: 63  NPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMS-----------------------PT 99

Query: 74  LHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRD 133
           + LP   P P VLPGP  +PSD STE  +TVLEGE+ISCF VGGEKRLCLPQ+LNSVLR+
Sbjct: 100 VFLPL--PSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLRE 157

Query: 134 FSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGG 193
           F+LQQIN VCDEL+IYCSRCT+DQL ILKV+GILPF+APSCGLIT TDA+RLCNALL   
Sbjct: 158 FTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPR 217

Query: 194 AYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLM 253
            +P       A S    L+ +  +  V HEC GKC+GL  P+ Y  P A CIQCL+C  M
Sbjct: 218 TFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGM 277

Query: 254 YPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDY 313
           + P  FV+HSH++ + RTCHWGF+SA W  Y+ ++Q Y G  E+ +L   L+++KEKF  
Sbjct: 278 FAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSM 337

Query: 314 GNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLAGSSNKSLGCVHPR 373
            +  + +                    S++ APS  +  S                    
Sbjct: 338 RSGKRNQ--------------------SKTDAPSGMELQS-------------------- 357

Query: 374 QRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVAL-APPAQQKVVSS 432
                   W P +      +S    + +  S+Y Y   +  VAPNV+L +  +Q K ++ 
Sbjct: 358 --------WYPVIKQEGDHVS-QTHSFLHPSYYLYMC-DKVVAPNVSLTSAVSQSKELTK 407

Query: 433 PPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEF 492
              + ++SR  E   +  + +K                V+ P+   + + ++++++  E 
Sbjct: 408 TEASKSISRQSEKAHSSGKLQK---------------TVSYPDVSLEEQEKMDLKTSREL 452

Query: 493 TSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGG 552
            S L +  S + TS   ++       R +        A A +P             L   
Sbjct: 453 CSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSP------------LLVKD 500

Query: 553 LDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNL 612
           +  ++ K K + EV++  +KQ+EKL+  LQ K+ L  E++ L  +K   ++E TE ++NL
Sbjct: 501 VICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSK--SMKELTEEQQNL 558

Query: 613 RKEIERLRAENEKKMKEANESRLRLKRELEQ-ARQARVCDKGCEAGRLRAKYSAQIEDLQ 671
           +KE+E L+ E+ ++M+E    +  L+++LEQ  +Q   CD   E  +  A+Y+ Q+ +L+
Sbjct: 559 QKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK-EAEYAGQLAELR 617

Query: 672 VKLQHAEADREQLRADLLREREAREHLEKVVKELQEQL 709
            +L HAEADR++L+ +L +EREAR+ LE ++KEL+ Q+
Sbjct: 618 QRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQI 655


>gi|223029418 SKI-like isoform 1 [Homo sapiens]
          Length = 684

 Score =  426 bits (1095), Expect = e-119
 Identities = 262/698 (37%), Positives = 384/698 (55%), Gaps = 107/698 (15%)

Query: 14  HPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPV 73
           +P L+ TL QFHLSS SSLGGPAAFSAR +QE+                         P 
Sbjct: 83  NPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMS-----------------------PT 119

Query: 74  LHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRD 133
           + LP   P P VLPGP  +PSD STE  +TVLEGE+ISCF VGGEKRLCLPQ+LNSVLR+
Sbjct: 120 VFLPL--PSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLRE 177

Query: 134 FSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGG 193
           F+LQQIN VCDEL+IYCSRCT+DQL ILKV+GILPF+APSCGLIT TDA+RLCNALL   
Sbjct: 178 FTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPR 237

Query: 194 AYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLM 253
            +P       A S    L+ +  +  V HEC GKC+GL  P+ Y  P A CIQCL+C  M
Sbjct: 238 TFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGM 297

Query: 254 YPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDY 313
           + P  FV+HSH++ + RTCHWGF+SA W  Y+ ++Q Y G  E+ +L   L+++KEKF  
Sbjct: 298 FAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSM 357

Query: 314 GNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLAGSSNKSLGCVHPR 373
            +  + +                    S++ APS  +  S                    
Sbjct: 358 RSGKRNQ--------------------SKTDAPSGMELQS-------------------- 377

Query: 374 QRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVAL-APPAQQKVVSS 432
                   W P +      +S    + +  S+Y Y   +  VAPNV+L +  +Q K ++ 
Sbjct: 378 --------WYPVIKQEGDHVS-QTHSFLHPSYYLYMC-DKVVAPNVSLTSAVSQSKELTK 427

Query: 433 PPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEF 492
              + ++SR  E   +  + +K                V+ P+   + + ++++++  E 
Sbjct: 428 TEASKSISRQSEKAHSSGKLQK---------------TVSYPDVSLEEQEKMDLKTSREL 472

Query: 493 TSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGG 552
            S L +  S + TS   ++       R +        A A +P             L   
Sbjct: 473 CSRLDASISNNSTSKRKSESATCNLVRDINKVGIGLVAAASSP------------LLVKD 520

Query: 553 LDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNL 612
           +  ++ K K + EV++  +KQ+EKL+  LQ K+ L  E++ L  +K   ++E TE ++NL
Sbjct: 521 VICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSK--SMKELTEEQQNL 578

Query: 613 RKEIERLRAENEKKMKEANESRLRLKRELEQ-ARQARVCDKGCEAGRLRAKYSAQIEDLQ 671
           +KE+E L+ E+ ++M+E    +  L+++LEQ  +Q   CD   E  +  A+Y+ Q+ +L+
Sbjct: 579 QKELESLQNEHAQRMEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDK-EAEYAGQLAELR 637

Query: 672 VKLQHAEADREQLRADLLREREAREHLEKVVKELQEQL 709
            +L HAEADR++L+ +L +EREAR+ LE ++KEL+ Q+
Sbjct: 638 QRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQI 675


>gi|223029420 SKI-like isoform 2 [Homo sapiens]
          Length = 638

 Score =  365 bits (936), Expect = e-100
 Identities = 245/697 (35%), Positives = 351/697 (50%), Gaps = 151/697 (21%)

Query: 14  HPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPV 73
           +P L+ TL QFHLSS SSLGGPAAFSAR +QE+                         P 
Sbjct: 83  NPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMS-----------------------PT 119

Query: 74  LHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRD 133
           + LP   P P VLPGP  +PSD STE  +TVLEGE+ISCF VGGEKRLCLPQ+LNSVLR+
Sbjct: 120 VFLPL--PSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLRE 177

Query: 134 FSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKTDAERLCNALLYGG 193
           F+LQQIN VCDEL+IYCSRCT+DQL ILKV+GILPF+APSCGLIT TDA+RLCNALL   
Sbjct: 178 FTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPR 237

Query: 194 AYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLM 253
            +P       A S    L+ +  +  V HEC GKC+GL  P+ Y  P A CIQCL+C  M
Sbjct: 238 TFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGM 297

Query: 254 YPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDY 313
           + P  FV+HSH++ + RTCHWGF+SA W  Y+ ++Q Y G  E+ +L   L+++KEKF  
Sbjct: 298 FAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSM 357

Query: 314 GNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLAGSSNKSLGCVHPR 373
            +  + +                    S++ APS  +  S                    
Sbjct: 358 RSGKRNQ--------------------SKTDAPSGMELQS-------------------- 377

Query: 374 QRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVALAPPAQQKVVSSP 433
                   W P +      +S    + +  S+Y Y   +  VAPNV+L            
Sbjct: 378 --------WYPVIKQEGDHVS-QTHSFLHPSYYLYMC-DKVVAPNVSL------------ 415

Query: 434 PCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEFT 493
              +AVS++ E   T                                EA   + S    +
Sbjct: 416 --TSAVSQSKELTKT--------------------------------EANASI-SNNSTS 440

Query: 494 SSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELE-HLRQALEGG 552
              S  ++ +     +   +G   A + P  V D     D    +E  +  +L+Q  +  
Sbjct: 441 KRKSESATCNLVRDINKVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQ--QEK 498

Query: 553 LDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNL 612
           L+    K++ L   VKM +   + +    + +++L +ELE L+    +++ E    +++L
Sbjct: 499 LNLILQKKQQLQMEVKM-LSSSKSMKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKDL 557

Query: 613 RKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQV 672
            K++E++      K K   +S L   +E                    A+Y+ Q+ +L+ 
Sbjct: 558 EKKLEQI-----MKQKCTCDSNLEKDKE--------------------AEYAGQLAELRQ 592

Query: 673 KLQHAEADREQLRADLLREREAREHLEKVVKELQEQL 709
           +L HAEADR++L+ +L +EREAR+ LE ++KEL+ Q+
Sbjct: 593 RLDHAEADRQELQDELRQEREARQKLEMMIKELKLQI 629


>gi|239757043 PREDICTED: functional smad suppressing element 18
           [Homo sapiens]
          Length = 996

 Score =  132 bits (332), Expect = 1e-30
 Identities = 83/230 (36%), Positives = 123/230 (53%), Gaps = 24/230 (10%)

Query: 102 ETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEIL 161
           + +L G  I   V+ G++RLCL QI N++L++FS  +I+     L I C +CT  QLEIL
Sbjct: 43  QVILYGIPIVSLVIDGQERLCLAQISNTLLKNFSYNEIHNRRVALGITCVQCTPVQLEIL 102

Query: 162 KVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVY 221
           +  G +P S+  CG+ITK +AERLC + L G   PP      A               V 
Sbjct: 103 RRAGAMPISSRRCGMITKREAERLCKSFL-GENRPPKLPDNFAFD-------------VS 148

Query: 222 HECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSAN- 280
           HEC   C+G  +P  Y+S  A CI+C  C + + P+KF+ HSH+  + +  +   D+AN 
Sbjct: 149 HECAWGCRGSFIPARYNSSRAKCIKCSYCNMYFSPNKFIFHSHRTPDAK--YTQPDAANF 206

Query: 281 --WRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRVSSEP 328
             WR ++ L    T K  Q  L    +DVK  F+ G++ KR +P+  + P
Sbjct: 207 NSWRRHLKL----TDKSPQDELVFAWEDVKAMFNGGSR-KRALPQPGAHP 251


>gi|239751555 PREDICTED: functional smad suppressing element 18
           [Homo sapiens]
          Length = 1252

 Score =  132 bits (332), Expect = 1e-30
 Identities = 83/230 (36%), Positives = 123/230 (53%), Gaps = 24/230 (10%)

Query: 102 ETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEIL 161
           + +L G  I   V+ G++RLCL QI N++L++FS  +I+     L I C +CT  QLEIL
Sbjct: 43  QVILYGIPIVSLVIDGQERLCLAQISNTLLKNFSYNEIHNRRVALGITCVQCTPVQLEIL 102

Query: 162 KVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVY 221
           +  G +P S+  CG+ITK +AERLC + L G   PP      A               V 
Sbjct: 103 RRAGAMPISSRRCGMITKREAERLCKSFL-GENRPPKLPDNFAFD-------------VS 148

Query: 222 HECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSAN- 280
           HEC   C+G  +P  Y+S  A CI+C  C + + P+KF+ HSH+  + +  +   D+AN 
Sbjct: 149 HECAWGCRGSFIPARYNSSRAKCIKCSYCNMYFSPNKFIFHSHRTPDAK--YTQPDAANF 206

Query: 281 --WRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRVSSEP 328
             WR ++ L    T K  Q  L    +DVK  F+ G++ KR +P+  + P
Sbjct: 207 NSWRRHLKL----TDKSPQDELVFAWEDVKAMFNGGSR-KRALPQPGAHP 251


>gi|239746067 PREDICTED: functional smad suppressing element 18
           [Homo sapiens]
          Length = 1252

 Score =  132 bits (332), Expect = 1e-30
 Identities = 83/230 (36%), Positives = 123/230 (53%), Gaps = 24/230 (10%)

Query: 102 ETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEIL 161
           + +L G  I   V+ G++RLCL QI N++L++FS  +I+     L I C +CT  QLEIL
Sbjct: 43  QVILYGIPIVSLVIDGQERLCLAQISNTLLKNFSYNEIHNRRVALGITCVQCTPVQLEIL 102

Query: 162 KVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVY 221
           +  G +P S+  CG+ITK +AERLC + L G   PP      A               V 
Sbjct: 103 RRAGAMPISSRRCGMITKREAERLCKSFL-GENRPPKLPDNFAFD-------------VS 148

Query: 222 HECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSAN- 280
           HEC   C+G  +P  Y+S  A CI+C  C + + P+KF+ HSH+  + +  +   D+AN 
Sbjct: 149 HECAWGCRGSFIPARYNSSRAKCIKCSYCNMYFSPNKFIFHSHRTPDAK--YTQPDAANF 206

Query: 281 --WRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRVSSEP 328
             WR ++ L    T K  Q  L    +DVK  F+ G++ KR +P+  + P
Sbjct: 207 NSWRRHLKL----TDKSPQDELVFAWEDVKAMFNGGSR-KRALPQPGAHP 251


>gi|73476377 LBXCOR1 homolog [Homo sapiens]
          Length = 921

 Score =  125 bits (314), Expect = 1e-28
 Identities = 84/248 (33%), Positives = 126/248 (50%), Gaps = 25/248 (10%)

Query: 102 ETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEIL 161
           ET L G  I   V+ G++RLCL QI N++L+++S  +I+     L I C +CT  QLEIL
Sbjct: 70  ETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEIL 129

Query: 162 KVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVY 221
           +  G +P S+  CG+ITK +AERLC + L  G + PP   +L  + A           V 
Sbjct: 130 RRAGAMPISSRRCGMITKREAERLCKSFL--GEHKPP---KLPENFAFD---------VV 175

Query: 222 HECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSAN- 280
           HEC    +G  +P  Y+S  A CI+C  C + + P+KF+ HSH+  + +  +   D+AN 
Sbjct: 176 HECAWGSRGSFIPARYNSSRAKCIKCGYCSMYFSPNKFIFHSHRTPDAK--YTQPDAANF 233

Query: 281 --WRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRVSSEPPASIRPKTDD 338
             WR ++ LS     K     L    +DVK  F+ G +    +      PP       +D
Sbjct: 234 NSWRRHLKLSD----KSATDELSHAWEDVKAMFNGGTRCGAEM--APGPPPHKSLRCGED 287

Query: 339 TSSQSPAP 346
            ++  P P
Sbjct: 288 EAAGPPGP 295



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 24/99 (24%), Positives = 48/99 (48%), Gaps = 12/99 (12%)

Query: 612 LRKEIERL-RAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDL 670
           + K+IE L R E +K + E  E R +L+RE +  +              + +   ++   
Sbjct: 809 VEKDIENLAREELQKLLLEQMELRKKLEREFQSLKD-----------NFQDQMKRELAYR 857

Query: 671 QVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQL 709
           +  +Q  +  R+ L  +L +ER+AR  +++ +KE  + L
Sbjct: 858 EEMVQQLQIVRDTLCNELDQERKARYAIQQKLKEAHDAL 896


>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
          Length = 749

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 82/343 (23%), Positives = 143/343 (41%), Gaps = 51/343 (14%)

Query: 345 APSEKDKPSSWLRTLAGSSNKSLGCVHPRQRLSA-FRPWSPAVSASEKELSPHLPALIRD 403
           A  +K++    +  L   + +++   +P+ R  A  R W P+ S       PHLP   R 
Sbjct: 292 ASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSL------PHLPGTPRP 345

Query: 404 SFYSYKSFETAVAPNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQPRKRKLTVDTPG 463
           +        +++ P    A PAQ +   SP     V R  +       P K    V    
Sbjct: 346 T--------SSLPPGSVKAAPAQVRP-PSPGNIRPVKREVKVEPEKKDPEKEPQKVANEP 396

Query: 464 APETLAPVAAPEE---DKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARA 520
           + +  AP+   EE   ++ + AE EV       +   + S+P+  S+ +   + +P   +
Sbjct: 397 SLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPA-SAPAPASAPAPAPVPTPAMVS 455

Query: 521 LPSAVPDAAAPADAPSG---------LEAELEHL---------RQALEGGLDTKEAKEKF 562
            PS+  +A+A     +G         L AE   L         R+  E     ++ +E+ 
Sbjct: 456 APSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREEL 515

Query: 563 LHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKR---------NLR 613
              V + R  + E+ S  L+A+++  +E +  R A++  LRE  EA+R          +R
Sbjct: 516 AQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVR 575

Query: 614 KEIERLRAENEKKMKEANESRLRLKRELEQ----ARQARVCDK 652
           +E ER+R E EK  +   + RL  K+ LE+     R+    DK
Sbjct: 576 EEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDK 618



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 63/281 (22%), Positives = 101/281 (35%), Gaps = 17/281 (6%)

Query: 343 SPAPSEKDKPSSWLRTLAGSSNKSLGCVHPRQRLSAFRPWS------PAVSASEKELSPH 396
           +P P+    P S     A     S G + P +R     P        P   A+E  L   
Sbjct: 342 TPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGR 401

Query: 397 LPALIRDSFYSYKSFETAVAPNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQPRKRK 456
            P L++    + +   T   P V  A PA     +S P A A + AP P+ T        
Sbjct: 402 AP-LVKVEEATVEE-RTPAEPEVGPAAPAMAPAPASAP-APASAPAPAPVPTPAMVSAPS 458

Query: 457 LTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSP 516
            TV+   + +T A    PEE     AE    +RE+                   ++L   
Sbjct: 459 STVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQR 518

Query: 517 GARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKM------- 569
            A    +   + +   +A    E E +  RQA E  L  +E  E+   +  +        
Sbjct: 519 VAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEA 578

Query: 570 -RVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAK 609
            RV+QE +     + +  L ++     + K+ +  EAT+ K
Sbjct: 579 ERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKK 619


>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
           sapiens]
          Length = 693

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 58/194 (29%), Positives = 98/194 (50%), Gaps = 16/194 (8%)

Query: 526 PDAAAPA--DAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQA 583
           P  A PA       L+ E +HLRQ +EG L+ K   +   ++ + +  K++++    LQ 
Sbjct: 286 PSLAPPAVTSVVEQLQDEAKHLRQEVEG-LEGKLQSQVENNQALSLLSKEQKQ---RLQE 341

Query: 584 KRSLHQELEFLRVAKKEKLREATEAKRNLRKEI----ERLRAENEKKMKEANESRLRLKR 639
           +  + +E E  RV ++E+L E  E  R  +K +    ERLR + ++  K+  E RLR + 
Sbjct: 342 QEEMLREQEVQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQ--EERLRKEE 399

Query: 640 ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQV----KLQHAEADREQLRADLLREREAR 695
           E  Q ++ R+ D+     +   +   Q E L +    KL    A+ +    DL  E+++ 
Sbjct: 400 ERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNEKKSA 459

Query: 696 EHLEKVVKELQEQL 709
             LE+ VKELQE+L
Sbjct: 460 LQLEQQVKELQEKL 473



 Score = 33.9 bits (76), Expect = 0.55
 Identities = 39/213 (18%), Positives = 79/213 (37%), Gaps = 13/213 (6%)

Query: 511 KDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMR 570
           K  G P          D++       G  +  +   Q L   L++       L+E ++  
Sbjct: 36  KSPGIPAGAKTKKKKTDSSPETTTSGGGHSPGDSQYQELAVALESSSVTISQLNENIESL 95

Query: 571 VKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLR------KEIERLRAENE 624
            +Q++++   L+  +  + E+   ++ + E +   T  K +L+      K   R   E  
Sbjct: 96  KQQKKQVEHQLEEAKKTNNEIHKAQMERLETINILTLEKADLKTTLYHTKRAARHFEEES 155

Query: 625 KKMKEANESRLRLKRELEQA-------RQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHA 677
           K +    +  L+  +ELE+A       +Q       C    L  +    I++  +   H 
Sbjct: 156 KDLAGRLQYSLQRIQELERALCAVSTQQQEEDRSSSCREAVLHRRLQQTIKERALLNAHV 215

Query: 678 EADREQLRADLLREREAREHLEKVVKELQEQLW 710
               E L+   L   E  +H++      QE++W
Sbjct: 216 TQVTESLKQVQLERDEYAKHIKGERARWQERMW 248


>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
           sapiens]
          Length = 693

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 58/194 (29%), Positives = 98/194 (50%), Gaps = 16/194 (8%)

Query: 526 PDAAAPA--DAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQA 583
           P  A PA       L+ E +HLRQ +EG L+ K   +   ++ + +  K++++    LQ 
Sbjct: 286 PSLAPPAVTSVVEQLQDEAKHLRQEVEG-LEGKLQSQVENNQALSLLSKEQKQ---RLQE 341

Query: 584 KRSLHQELEFLRVAKKEKLREATEAKRNLRKEI----ERLRAENEKKMKEANESRLRLKR 639
           +  + +E E  RV ++E+L E  E  R  +K +    ERLR + ++  K+  E RLR + 
Sbjct: 342 QEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQ--EERLRKEE 399

Query: 640 ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQV----KLQHAEADREQLRADLLREREAR 695
           E  Q ++ R+ D+     +   +   Q E L +    KL    A+ +    DL  E+++ 
Sbjct: 400 ERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNEKKSA 459

Query: 696 EHLEKVVKELQEQL 709
             LE+ VKELQE+L
Sbjct: 460 LQLEQQVKELQEKL 473



 Score = 33.5 bits (75), Expect = 0.72
 Identities = 39/213 (18%), Positives = 80/213 (37%), Gaps = 13/213 (6%)

Query: 511 KDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMR 570
           K  G P          D++       G  +  +   Q L   L++       L+E ++  
Sbjct: 36  KSPGIPAGAKTKKKKTDSSPETTTSGGGHSPGDSQYQELAVALESSSVTINQLNENIESL 95

Query: 571 VKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLR------KEIERLRAENE 624
            +Q++++   L+  +  + E+   ++ + E +   T  K +L+      K   R   E  
Sbjct: 96  KQQKKQVEHQLEEAKKTNNEIHKAQMEQLETINILTLEKADLKTTLYHTKRAARHFEEES 155

Query: 625 KKMKEANESRLRLKRELEQA-------RQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHA 677
           K +    +  L+  +ELE+A       +Q       C    L+ +    I++  +   H 
Sbjct: 156 KDLAGRLQYSLQHIQELERALCAVSTQQQEEDRSSSCREAVLQRRLQQTIKERALLNAHV 215

Query: 678 EADREQLRADLLREREAREHLEKVVKELQEQLW 710
               E L+   L   E  +H++      QE++W
Sbjct: 216 TQVTESLKQVQLERDEYAKHIKGERARWQERMW 248


>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
           isoform 1 [Homo sapiens]
          Length = 693

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 58/194 (29%), Positives = 98/194 (50%), Gaps = 16/194 (8%)

Query: 526 PDAAAPA--DAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQA 583
           P  A PA       L+ E +HLRQ +EG L+ K   +   ++ + +  K++++    LQ 
Sbjct: 286 PSLAPPAVTSVVEQLQDEAKHLRQEVEG-LEGKLQSQVENNQALSLLSKEQKQ---RLQE 341

Query: 584 KRSLHQELEFLRVAKKEKLREATEAKRNLRKEI----ERLRAENEKKMKEANESRLRLKR 639
           +  + +E E  RV ++E+L E  E  R  +K +    ERLR + ++  K+  E RLR + 
Sbjct: 342 QEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQ--EERLRKEE 399

Query: 640 ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQV----KLQHAEADREQLRADLLREREAR 695
           E  Q ++ R+ D+     +   +   Q E L +    KL    A+ +    DL  E+++ 
Sbjct: 400 ERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNEKKSA 459

Query: 696 EHLEKVVKELQEQL 709
             LE+ VKELQE+L
Sbjct: 460 LQLEQQVKELQEKL 473



 Score = 34.7 bits (78), Expect = 0.32
 Identities = 41/211 (19%), Positives = 85/211 (40%), Gaps = 15/211 (7%)

Query: 500 SSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKEAK 559
           SSP  T+S      G    + L  A+  ++   +    L   +E L+Q  +      E  
Sbjct: 53  SSPETTTSGGGHSPGDSQYQELAVALESSSVTINQ---LNENIESLKQQKKQVEHQLEEA 109

Query: 560 EKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERL 619
           +K  +E+ K +++Q E ++     K  L   L   + A +    E+ +    L+  ++R+
Sbjct: 110 KKTNNEIHKAQMEQLETINILTLEKADLKTTLYHTKRAARHFEEESKDLAGRLQYSLQRI 169

Query: 620 RAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEA 679
           + E E+ +   +       ++ E+ R +      C    L+ +    I++  +   H   
Sbjct: 170 Q-ELERALSAVST------QQQEEDRSS-----SCREAVLQRRLQQTIKERALLNAHVTQ 217

Query: 680 DREQLRADLLREREAREHLEKVVKELQEQLW 710
             E L+   L   E  +H++      QE++W
Sbjct: 218 VTESLKQVQLERDEYAKHIKGERARWQERMW 248


>gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo
           sapiens]
          Length = 693

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 58/194 (29%), Positives = 98/194 (50%), Gaps = 16/194 (8%)

Query: 526 PDAAAPA--DAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQA 583
           P  A PA       L+ E +HLRQ +EG L+ K   +   ++ + +  K++++    LQ 
Sbjct: 286 PSLAPPAVTSVVEQLQDEAKHLRQEVEG-LEGKLQSQVENNQALSLLSKEQKQ---RLQE 341

Query: 584 KRSLHQELEFLRVAKKEKLREATEAKRNLRKEI----ERLRAENEKKMKEANESRLRLKR 639
           +  + +E E  RV ++E+L E  E  R  +K +    ERLR + ++  K+  E RLR + 
Sbjct: 342 QEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQEQRLRKQ--EERLRKEE 399

Query: 640 ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQV----KLQHAEADREQLRADLLREREAR 695
           E  Q ++ R+ D+     +   +   Q E L +    KL    A+ +    DL  E+++ 
Sbjct: 400 ERLQKQEKRLWDQEERLWKKEERLQKQEERLALSQNHKLDKQLAEPQCSFEDLNNEKKSA 459

Query: 696 EHLEKVVKELQEQL 709
             LE+ VKELQE+L
Sbjct: 460 LQLEQQVKELQEKL 473


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 99/426 (23%), Positives = 172/426 (40%), Gaps = 51/426 (11%)

Query: 314 GNKYKRRVPRVSSEP-PASIRPKTDDTSSQSPAPSEKD---KPSSWLRTLAGSSNKSLGC 369
           G + +RR P     P P   RP+      +     E++   + S+  R  +    +SL  
Sbjct: 386 GERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPA 445

Query: 370 VHPRQRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVALAPPAQQKV 429
             PR RLSA         ++  ELSP             KS     +P+ +   PA    
Sbjct: 446 -SPRARLSA---------STASELSP-------------KSKARPSSPSTSWHRPASP-C 481

Query: 430 VSSPPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESR 489
            S  P      + P P  T   P+ R    +   A E+  P AA  EDK S+++    + 
Sbjct: 482 PSPGPGHTLPPKPPSPRGTTASPKGRVRRKEE--AKES--PSAAGPEDK-SQSKRRASNE 536

Query: 490 EEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQAL 549
           +E  +  S   SP+ + + +      P A     A    + PA AP    ++       +
Sbjct: 537 KESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPPVTPSK------PM 590

Query: 550 EGGLDTKEAKEKFLHEVVKMRVKQE-EKLSAALQAKRSLH-QELEFLRVAKKEKLREATE 607
            G  D +EA      +  + R ++E E+    LQA+R    +E +  R A+    REA  
Sbjct: 591 AGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAEREAEA 650

Query: 608 AKRNLRKEIERLRAENE-----KKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAK 662
            +R  ++  E+ +AE E     +K KE  E+R R + E ++  + +   +  +  + R K
Sbjct: 651 RRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRK 710

Query: 663 YSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGSEG 722
              ++E++  + + +E    + + D  +E  A     + VK ++ +  P  + EA   E 
Sbjct: 711 ---RLEEIMKRTRKSEVSETKQKQD-SKEANANGSSPEPVKAVEARS-PGLQKEAVQKEE 765

Query: 723 AAELEP 728
               EP
Sbjct: 766 PIPQEP 771



 Score = 36.6 bits (83), Expect = 0.085
 Identities = 64/236 (27%), Positives = 96/236 (40%), Gaps = 50/236 (21%)

Query: 422 APPAQQKVVSSPPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSE 481
           APPA   V  +PP       +PE   +   P    L  DTP  P+T  P A        +
Sbjct: 13  APPAV--VARTPP---EPRPSPEGDPSPPPPPMSALVPDTP--PDT--PPAMKNATSSKQ 63

Query: 482 AEVEVES------------REEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAA 529
             +E ES            +EE  SS +    P+   +   +D   P   + PS  P A 
Sbjct: 64  LPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPT-PPAMGPRDARPPRRSSQPS--PTAV 120

Query: 530 APADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQ 589
             +D+P   +              + K+A E+  H++ K R ++  K    L AK+++  
Sbjct: 121 PASDSPPTKQ--------------EVKKAGER--HKLAKERREERAKY---LAAKKAVWL 161

Query: 590 ELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQAR 645
           E E     K + LRE    +R  R E +RL+AE   + + A E R R K E  + R
Sbjct: 162 EKE----EKAKALREKQLQERRRRLEEQRLKAE---QRRAALEERQRQKLEKNKER 210



 Score = 30.0 bits (66), Expect = 7.9
 Identities = 24/71 (33%), Positives = 28/71 (39%), Gaps = 9/71 (12%)

Query: 31  SLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPVLHLPAIQPP-------P 83
           S  GP   S    + + +KESA  A  A  PAP P  T  PP    P  + P        
Sbjct: 519 SAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSP--TPAPPQKEQPPAETPTDAAVLTS 576

Query: 84  PVLPGPFFMPS 94
           P  P P   PS
Sbjct: 577 PPAPAPPVTPS 587


>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 102/408 (25%), Positives = 171/408 (41%), Gaps = 40/408 (9%)

Query: 332 IRPKTDDTSSQSPAPSEKDKPSSWLRTLAGSSNKSLGCVHPRQRLSAFRPWSPAVSASEK 391
           + PK D T S+    SEK+ P   +      S +      P+++ SA    S   S  E 
Sbjct: 328 VTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDAS-QEL 386

Query: 392 ELSPHL--PALIRDSFYSYKSFE-TAVAPNVALAPPAQQKVVSSPPCAAAVSRAPEPLA- 447
           E+S H+  P L        KSF          ++       V SP    A  +A +PL  
Sbjct: 387 EISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGI 446

Query: 448 ---TCTQPRKRKL-TVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPS 503
                +Q  + +L +  + G  E L+P   P E++       + + EE          P 
Sbjct: 447 EDKDDSQSSQDELQSKQSKGLEERLSP-PLPHEERAQSPPRSLATEEE--PPQGPEGQPE 503

Query: 504 FTSSSSAKDLG--SPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEK 561
           +     A++LG  S  + +L  ++    AP+  P+  E   E   QA E G   +EA++ 
Sbjct: 504 W---KEAEELGEDSAASLSLQLSLQREQAPS-PPAACEKGKEQHSQAEELGPGQEEAEDP 559

Query: 562 FLHEVVKMR------------VKQEEKLS-AALQAKRS-----LHQELEFLRVAKKEKLR 603
                V               V   E+LS AAL+A        L Q+   L  +K+EK++
Sbjct: 560 EEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQ 619

Query: 604 EATEAK-RNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAK 662
           +  E   +   +EI RL  + E+ +    E RL+   E E+AR      +     R + +
Sbjct: 620 QLREKLCQEEEEEILRLHQQKEQSLSSLRE-RLQKAIEEEEARMREEESQRLSWLRAQVQ 678

Query: 663 YSAQIEDLQVKLQHAEADREQLRADLLREREA-REHLEKVVKELQEQL 709
            S Q ++ Q++ +  EA  ++LR +L  +++A R  LE+  +++ EQL
Sbjct: 679 SSTQADEDQIRAEQ-EASLQKLREELESQQKAERASLEQKNRQMLEQL 725



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 92/401 (22%), Positives = 148/401 (36%), Gaps = 50/401 (12%)

Query: 326 SEPPASIRPKTDDTSSQSPAPSEKDK-------PSSWLRTLAGSSNKSLGCVH-PRQRLS 377
           ++ P  I  K D  SSQ    S++ K       P       A S  +SL     P Q   
Sbjct: 440 AQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPE 499

Query: 378 AFRPWSPAVSASE-------------KELSPHLPALIRDSFYSYKSFETAVAPNVALAPP 424
               W  A    E             +E +P  PA        +   E  + P    A  
Sbjct: 500 GQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEE-LGPGQEEAED 558

Query: 425 AQQKVVSSP-PCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAE 483
            ++KV  SP P  +   R+ EP+A   Q  +  L        + L      E+D+    E
Sbjct: 559 PEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVL------EQDQRHLLE 612

Query: 484 VEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARA-LPSAVPDAAA-----PADAPSG 537
            + E  ++    L              K+      R  L  A+ +  A      +   S 
Sbjct: 613 SKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSW 672

Query: 538 LEAELEHLRQALEGGLDTK-EAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRV 596
           L A+++   QA E  +  + EA  + L E ++ + K E + S   + ++ L Q  E +  
Sbjct: 673 LRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAE-RASLEQKNRQMLEQLKEEIEA 731

Query: 597 AKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEA 656
           ++K +      AK    K +++LR + E + KEA  +   L++E   A   R+C      
Sbjct: 732 SEKSEQAALNAAKE---KALQQLREQLEGERKEAVAT---LEKE-HSAELERLCSS---- 780

Query: 657 GRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREH 697
             L AK+   +  LQ K+Q A+   E      L + E R H
Sbjct: 781 --LEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVH 819



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 47/197 (23%), Positives = 87/197 (44%), Gaps = 25/197 (12%)

Query: 536  SGLEAELEHL----RQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQ-- 589
            +G E EL  L    RQ +EG  + +  K K  H+ V  + +++ +     Q    L    
Sbjct: 826  AGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLT 885

Query: 590  -ELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKE-------------ANESRL 635
             ELE L+ A + +L    + +    +++ R   E E+K+++             A  + L
Sbjct: 886  GELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALL 945

Query: 636  RLKRELEQARQARVCDKGCEAGRLRAKYSA---QIEDLQVKLQHAEADREQLRADLLRER 692
             ++ E  +  + ++ D   +      + +A   Q+E+ Q +  H     +QLR ++L E 
Sbjct: 946  EVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLR-EILDEL 1004

Query: 693  EARE-HLEKVVKELQEQ 708
            +AR+  LE  V  LQ Q
Sbjct: 1005 QARKLKLESQVDLLQAQ 1021



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 52/208 (25%), Positives = 85/208 (40%), Gaps = 30/208 (14%)

Query: 540 AELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAAL-QAKRSLHQ--------- 589
           AELE L  +LE     +E       ++ + + K+E +L   L Q +  +HQ         
Sbjct: 772 AELERLCSSLEA--KHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYE 829

Query: 590 -ELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLR------LKRELE 642
            EL  L   K++++    E + +  KE  +      ++  EA E + R      L  ELE
Sbjct: 830 HELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELE 889

Query: 643 QARQARVCDKGCEAGRLRAKYSAQIEDL-------QVKLQHAEADREQLRADLLREREAR 695
           + ++A       E   +R +   ++EDL       + KLQ  E D E    D+       
Sbjct: 890 RLQRAHER----ELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALL 945

Query: 696 EHLEKVVKELQEQLWPRARPEAAGSEGA 723
           E  E+  +  ++QL    R  A  SE A
Sbjct: 946 EVQEETARREKQQLLDVQRQVALKSEEA 973


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 65/265 (24%), Positives = 115/265 (43%), Gaps = 42/265 (15%)

Query: 483  EVEVESREEFTSSLSSLSSPSFTSSSSAKDLGS------PGARALPSAVPDAA------- 529
            E  +E++EEF      L +      SS  D+G          RAL   V +         
Sbjct: 1493 EEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE 1552

Query: 530  ----APADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKR 585
                A  DA   LE  ++ ++   E  L T++ + +   E  ++ +KQ  +L A L+ +R
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE---EKKRLLIKQVRELEAELEDER 1609

Query: 586  SLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLK---RELE 642
                    L VA K+K+       ++L  +IE      ++ +K+  + + ++K   RELE
Sbjct: 1610 KQRA----LAVASKKKMEIDL---KDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELE 1662

Query: 643  QARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVV 702
            +AR +R             +  AQ ++ + KL+  EA+  QL+ +L     AR H E+  
Sbjct: 1663 EARASR------------DEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQER 1710

Query: 703  KELQEQLWPRARPEAAGSEGAAELE 727
             EL +++   A  ++A  +    LE
Sbjct: 1711 DELADEITNSASGKSALLDEKRRLE 1735



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 70/279 (25%), Positives = 120/279 (43%), Gaps = 62/279 (22%)

Query: 476  EDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAP 535
            E++D     E E+RE+ T +LS                    ARAL  A+       +A 
Sbjct: 1469 EERD---RAEAEAREKETKALSL-------------------ARALEEAL-------EAK 1499

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVVK-----------MRVKQEE---KLSAAL 581
               E + + LR  +E  + +K+   K +HE+ K           MR + EE   +L A  
Sbjct: 1500 EEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE 1559

Query: 582  QAKRSLHQELEFLRVAKKEKLR----EATEAKRNLRKEIERLRAENEKKMKE-----ANE 632
             AK  L   ++ ++   +  L+    +  E KR L K++  L AE E + K+     A++
Sbjct: 1560 DAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASK 1619

Query: 633  SRLR-----LKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRAD 687
             ++      L+ ++E A +AR      E  +   K  AQ++D Q +L+ A A R+++ A 
Sbjct: 1620 KKMEIDLKDLEAQIEAANKARD-----EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQ 1674

Query: 688  LLREREAREHLEKVVKELQEQLWPRARPEAAGSEGAAEL 726
                 +  + LE  + +LQE+L    R      +   EL
Sbjct: 1675 SKESEKKLKSLEAEILQLQEELASSERARRHAEQERDEL 1713



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 65/277 (23%), Positives = 119/277 (42%), Gaps = 32/277 (11%)

Query: 463  GAPETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALP 522
            G  ETL    A +  ++ +A++  E +E+F S  +S +         +++L +     L 
Sbjct: 1099 GDDETLHKNNALKVVRELQAQI-AELQEDFESEKASRNKAEKQKRDLSEELEALKTE-LE 1156

Query: 523  SAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQ-EEKLSAAL 581
              +   AA  +  +  E E+  L++ALE      EA+ + + +     +++  E+L  A 
Sbjct: 1157 DTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216

Query: 582  QAKRSLHQELEFLRVAKKE---------KLREATEAKRN-LRKEIERLRA---ENEKKMK 628
            + K +L +  + L    KE         +++  +E KR  L  +++ L A   E ++   
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV 1276

Query: 629  EANESRLRLKRELEQARQA--RVCDKGCEAGRLRAKYSAQIEDLQVKLQHA--------- 677
            E  E   +L+ EL+           KG +  +  A   +Q++D Q  LQ           
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSS 1336

Query: 678  -----EADREQLRADLLREREAREHLEKVVKELQEQL 709
                 E ++  L+     E EAR++LEK V  LQ QL
Sbjct: 1337 RIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL 1373



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 55/203 (27%), Positives = 88/203 (43%), Gaps = 17/203 (8%)

Query: 538  LEAELEHLRQALEGGLDT----KEAKEKFLHEVVKMRVKQEEKLS---AALQAKRSLHQE 590
            L  ELE L+  LE  LDT    +E + K   EV +++   EE+     A +Q  R  H  
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHAT 1203

Query: 591  -LEFLRVAKKEKLREATEAKRNLRKEIERLRAEN-----EKKMKEANESRLRLKRELEQA 644
             LE L     E+L +A   K NL K  + L  +N     E K+ +  ++    KR+   A
Sbjct: 1204 ALEEL----SEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDA 1259

Query: 645  RQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKE 704
            +   +  K  E  RLR + + +   LQ +L +     E+     ++  +    LE  +++
Sbjct: 1260 QVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD 1319

Query: 705  LQEQLWPRARPEAAGSEGAAELE 727
             QE L    R +   S    +LE
Sbjct: 1320 TQELLQEETRQKLNLSSRIRQLE 1342



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 48/192 (25%), Positives = 88/192 (45%), Gaps = 24/192 (12%)

Query: 529  AAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRS-- 586
            A    A + L AE E +R  L      K+  E+ LH++ + RV++EE+ +  LQ ++   
Sbjct: 893  AEQLQAETELFAEAEEMRARLAA---KKQELEEILHDL-ESRVEEEEERNQILQNEKKKM 948

Query: 587  ------LHQELEFLRVAKKEKLREATEAKRNLRK---EIERLRAENEKKMKEANESRLRL 637
                  L ++L+    A+++   E   A+  ++K   EI  L  +N K +KE      R+
Sbjct: 949  QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRI 1008

Query: 638  KRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREH 697
                 Q  +    +K     ++R K    I DL+ +L+  E  R++L        +A+  
Sbjct: 1009 AECSSQLAEEE--EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL-------EKAKRK 1059

Query: 698  LEKVVKELQEQL 709
            L+    +LQ+Q+
Sbjct: 1060 LDGETTDLQDQI 1071



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 62/283 (21%), Positives = 115/283 (40%), Gaps = 52/283 (18%)

Query: 472  AAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAP 531
            A  EE K+ EA+++ + R+   ++L  LS     +     +L     + L +   + A  
Sbjct: 1182 ALEEETKNHEAQIQ-DMRQRHATALEELSEQLEQAKRFKANL-EKNKQGLETDNKELACE 1239

Query: 532  ADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEK--------------- 576
                  ++AE EH R+ L+  +    AK   + E  ++RV+  EK               
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAK---VSEGDRLRVELAEKASKLQNELDNVSTLL 1296

Query: 577  ----------------LSAALQAKRSLHQE--------------LEFLRVAKKEKLREAT 606
                            L + LQ  + L QE              LE  + + +E+  E  
Sbjct: 1297 EEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEE 1356

Query: 607  EAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQ 666
            EA++NL K++  L+++     K+ ++  L     LE+A++  + D    + RL  K  A 
Sbjct: 1357 EARKNLEKQVLALQSQLADTKKKVDDD-LGTIESLEEAKKKLLKDAEALSQRLEEKALA- 1414

Query: 667  IEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQL 709
             + L+      + + + L  DL  +R+   +LEK  K+  + L
Sbjct: 1415 YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLL 1457



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 66/269 (24%), Positives = 115/269 (42%), Gaps = 36/269 (13%)

Query: 475  EEDKDSEAEVEVESREEFTSSLSSLSSP------SFTSSSSAKDLGSPGARALPSAVPDA 528
            EE + S  E+  +S+E     L SL +          SS  A+         L   + ++
Sbjct: 1662 EEARASRDEIFAQSKES-EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS 1720

Query: 529  AAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSL- 587
            A+   A    +  LE     LE  L+ +++  + L++  +    Q + L+A L A+RS  
Sbjct: 1721 ASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAA 1780

Query: 588  ------HQELEFLRVAKKEKLREATEAKRN--------LRKEIERLRAENEKKMKE---A 630
                   Q+LE      K KL+E   A ++        L  +I +L  + E++ KE   A
Sbjct: 1781 QKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAA 1840

Query: 631  NESRLRLKRELEQARQARVCDKGCEAGRLRAKYS-AQIEDLQVKLQHAEADREQLRADLL 689
            N+   R +++L++    +V D+   A + + +   A     Q+K Q  EA+ E  RA+  
Sbjct: 1841 NKLVRRTEKKLKEIFM-QVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANAS 1899

Query: 690  RER---------EAREHLEKVVKELQEQL 709
            R +         EA E L + V  L+ +L
Sbjct: 1900 RRKLQRELDDATEANEGLSREVSTLKNRL 1928



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 49/176 (27%), Positives = 90/176 (51%), Gaps = 23/176 (13%)

Query: 541  ELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK-K 599
            E E  RQ L+    T EAK K + E + +   Q  K    ++ K+ +       R+A+  
Sbjct: 961  EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKF---IKEKKLMED-----RIAECS 1012

Query: 600  EKLREATEAKRNL---RKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEA 656
             +L E  E  +NL   R + E + ++ E+++K+  ++R    +ELE+A++ ++  +  + 
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR----QELEKAKR-KLDGETTDL 1067

Query: 657  GRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLE---KVVKELQEQL 709
                A+  AQI++L+++L   E   E+L+  L R  +   H     KVV+ELQ Q+
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKE---EELQGALARGDDETLHKNNALKVVRELQAQI 1120



 Score = 33.1 bits (74), Expect = 0.94
 Identities = 56/279 (20%), Positives = 115/279 (41%), Gaps = 41/279 (14%)

Query: 466  ETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAV 525
            + L  V A  E K  + + +V+      S    L       +S  ++     +  L  A 
Sbjct: 1241 KVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAE 1300

Query: 526  PDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQ--- 582
                  A   + LE++L+  ++ L+     +E ++K L+   ++R  +EEK S   Q   
Sbjct: 1301 KKGIKFAKDAASLESQLQDTQELLQ-----EETRQK-LNLSSRIRQLEEEKNSLQEQQEE 1354

Query: 583  ---AKRSLHQELEFLR--VAKKEK--------LREATEAKRNLRKEIERLRAENEKKM-- 627
               A+++L +++  L+  +A  +K        +    EAK+ L K+ E L    E+K   
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA 1414

Query: 628  -KEANESRLRLKRELE----------------QARQARVCDKGCEAGRLRAKYSAQIEDL 670
              +  +++ RL++EL+                + +Q +      E   + A+Y+ + +  
Sbjct: 1415 YDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA 1474

Query: 671  QVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQL 709
            + + +  E     L   L    EA+E  E+  K+L+  +
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM 1513


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 58/255 (22%), Positives = 119/255 (46%), Gaps = 39/255 (15%)

Query: 476  EDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAP 535
            ED+ SE + +++  E    +L+ +      + +  K+L             + A   +  
Sbjct: 950  EDECSELKKDIDDLE---LTLAKVEKEKHATENKVKNL-----------TEEMAGLDETI 995

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEK---LSAALQAKRSLHQELE 592
            + L  E + L++A +  LD  +A+E  ++ + K ++K E++   L  +L+ ++ L  +LE
Sbjct: 996  AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055

Query: 593  FLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDK 652
              +   +  L+ A E+  ++  E ++L  + + K KE   S L+ K E EQA        
Sbjct: 1056 RAKRKLEGDLKLAQESIMDIENEKQQL--DEKLKKKEFEISNLQSKIEDEQA-------- 1105

Query: 653  GCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPR 712
                  L  +   +I++LQ +++  E + E  RA   +  + R  L + ++E+ E+L   
Sbjct: 1106 ------LGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL--- 1156

Query: 713  ARPEAAGSEGAAELE 727
               E AG   +A++E
Sbjct: 1157 ---EEAGGATSAQIE 1168



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 66/308 (21%), Positives = 127/308 (41%), Gaps = 70/308 (22%)

Query: 450  TQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSS 509
            T+ + + LT +  G  ET+A +   ++      +  ++  +     +++L+         
Sbjct: 977  TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIK---- 1032

Query: 510  AKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGL---------------- 553
                       L   V D     +    L  +LE  ++ LEG L                
Sbjct: 1033 -----------LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQ 1081

Query: 554  -DTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNL 612
             D K  K++F    ++ +++ E+ L   LQ K    +EL+    A+ E+L E  EA+R  
Sbjct: 1082 LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKI---KELQ----ARIEELEEEIEAERAS 1134

Query: 613  RKEIERLRAENEKKMKEANES------------RLRLKRELEQARQARVCDKG-----CE 655
            R + E+ R++  ++++E +E              +  KRE E  +  R  ++        
Sbjct: 1135 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1194

Query: 656  AGRLRAKYS-------AQIEDLQVKLQHAEADREQLRA---DLLRERE----AREHLEKV 701
            A  LR K++        QI++LQ   Q  E ++ +++    DL    E    A+ +LEK+
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKM 1254

Query: 702  VKELQEQL 709
             + L++QL
Sbjct: 1255 CRTLEDQL 1262



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 44/188 (23%), Positives = 98/188 (52%), Gaps = 30/188 (15%)

Query: 538  LEAELEHLRQALEGGLDTKEAKEKFLHEV--VKMRVKQEE-KLSAALQ-AKRSL-HQELE 592
            L+ E ++L+Q +    +      K +HE+  +K +V+QE+ +L AAL+ A+ SL H+E +
Sbjct: 1504 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563

Query: 593  FLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDK 652
             LR+  +            ++ E++R  AE ++++ +   + +R+   ++    A +  +
Sbjct: 1564 ILRIQLE---------LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSR 1614

Query: 653  GCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLRE--------REAREHLEKVVK- 703
              +A RL+ K    + +++++L HA     ++ A+ LR         ++ + HL+  ++ 
Sbjct: 1615 N-DAIRLKKKMEGDLNEMEIQLNHA----NRMAAEALRNYRNTQGILKDTQIHLDDALRS 1669

Query: 704  --ELQEQL 709
              +L+EQL
Sbjct: 1670 QEDLKEQL 1677



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 42/186 (22%), Positives = 81/186 (43%), Gaps = 19/186 (10%)

Query: 553  LDTKEA--------KEKFLHEVVKMRVKQEEKL---SAALQAKRSLHQELEFLRVAKKEK 601
            LD KEA        K+ F  ++ +++ + EE++   +A   A +S   + + LR    E+
Sbjct: 1297 LDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLR----EQ 1352

Query: 602  LREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRA 661
              E  E+K  L++ + +   E  +   +     ++   ELE+A++ ++  +   A     
Sbjct: 1353 YEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK-KLAQRLQAAEEHVE 1411

Query: 662  KYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGSE 721
              +A+   L+   Q  + + E L  D+ R   A   L+K  +   + L   A  +    E
Sbjct: 1412 AVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL---AEWKQKCEE 1468

Query: 722  GAAELE 727
              AELE
Sbjct: 1469 THAELE 1474



 Score = 33.5 bits (75), Expect = 0.72
 Identities = 46/226 (20%), Positives = 95/226 (42%), Gaps = 42/226 (18%)

Query: 538  LEAELEHLR----QALEGGLDTKEA-KEKFLHEVVKMRVKQEEKLSAALQAKRS--LHQE 590
            +E +L H      +AL    +T+   K+  +H    +R +++ K   A+  +R+  L  E
Sbjct: 1631 MEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAE 1690

Query: 591  LEFLRVA----------KKEKLREATE--------------AKRNLRKEIERLRAENEKK 626
            +E LR             +++L +A+E               K+ L  +I +++ E E  
Sbjct: 1691 IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDI 1750

Query: 627  MKEANESRLRLKRELEQARQ-----ARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
            ++EA  +  + K+ +  A        +  D      R++      ++DLQ++L  AE   
Sbjct: 1751 LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE--- 1807

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
               +  L   ++  + LE  V+EL+ ++    +  A   +G  + E
Sbjct: 1808 ---QLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHE 1850



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 34/169 (20%), Positives = 74/169 (43%), Gaps = 16/169 (9%)

Query: 538  LEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAA-----LQAKRSLHQELE 592
            L+A +E L + +E    ++   EK   ++ +   +  E+L  A      Q + +  +E E
Sbjct: 1117 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1176

Query: 593  FLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDK 652
            F ++  +  L EAT         + +  A++  ++ E  ++  R+K++LE+ +     + 
Sbjct: 1177 FQKM--RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEI 1234

Query: 653  GCEAGRLRA---------KYSAQIEDLQVKLQHAEADREQLRADLLRER 692
               A  +           K    +ED   +L+  E ++++L  DL  +R
Sbjct: 1235 DDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQR 1283



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 40/187 (21%), Positives = 81/187 (43%), Gaps = 38/187 (20%)

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKM--RVKQEEKLSAALQA-KRSLHQELE 592
            S ++ E+E +   L+   + +E  +K + +   M   +K+E+  SA L+  K+++ Q ++
Sbjct: 1741 SQMQGEMEDI---LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797

Query: 593  FLRV-----------AKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKREL 641
             L++             K+++++     R L  E+E  +  N + +K   +   R+K   
Sbjct: 1798 DLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELT 1857

Query: 642  EQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQ--------HAEADREQLRADLLRERE 693
             Q  + R             K   +++DL  KLQ         AE   EQ   +L + R+
Sbjct: 1858 YQTEEDR-------------KNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRK 1904

Query: 694  AREHLEK 700
             +  LE+
Sbjct: 1905 LQHELEE 1911


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 58/255 (22%), Positives = 119/255 (46%), Gaps = 39/255 (15%)

Query: 476  EDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAP 535
            ED+ SE + +++  E    +L+ +      + +  K+L             + A   +  
Sbjct: 950  EDECSELKKDIDDLE---LTLAKVEKEKHATENKVKNL-----------TEEMAGLDETI 995

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEK---LSAALQAKRSLHQELE 592
            + L  E + L++A +  LD  +A+E  ++ + K ++K E++   L  +L+ ++ L  +LE
Sbjct: 996  AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055

Query: 593  FLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDK 652
              +   +  L+ A E+  ++  E ++L  + + K KE   S L+ K E EQA        
Sbjct: 1056 RAKRKLEGDLKLAQESIMDIENEKQQL--DEKLKKKEFEISNLQSKIEDEQA-------- 1105

Query: 653  GCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPR 712
                  L  +   +I++LQ +++  E + E  RA   +  + R  L + ++E+ E+L   
Sbjct: 1106 ------LGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL--- 1156

Query: 713  ARPEAAGSEGAAELE 727
               E AG   +A++E
Sbjct: 1157 ---EEAGGATSAQIE 1168



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 66/308 (21%), Positives = 127/308 (41%), Gaps = 70/308 (22%)

Query: 450  TQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSS 509
            T+ + + LT +  G  ET+A +   ++      +  ++  +     +++L+         
Sbjct: 977  TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIK---- 1032

Query: 510  AKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGL---------------- 553
                       L   V D     +    L  +LE  ++ LEG L                
Sbjct: 1033 -----------LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQ 1081

Query: 554  -DTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNL 612
             D K  K++F    ++ +++ E+ L   LQ K    +EL+    A+ E+L E  EA+R  
Sbjct: 1082 LDEKLKKKEFEISNLQSKIEDEQALGIQLQKKI---KELQ----ARIEELEEEIEAERAS 1134

Query: 613  RKEIERLRAENEKKMKEANES------------RLRLKRELEQARQARVCDKG-----CE 655
            R + E+ R++  ++++E +E              +  KRE E  +  R  ++        
Sbjct: 1135 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1194

Query: 656  AGRLRAKYS-------AQIEDLQVKLQHAEADREQLRA---DLLRERE----AREHLEKV 701
            A  LR K++        QI++LQ   Q  E ++ +++    DL    E    A+ +LEK+
Sbjct: 1195 AATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKM 1254

Query: 702  VKELQEQL 709
             + L++QL
Sbjct: 1255 CRTLEDQL 1262



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 44/188 (23%), Positives = 98/188 (52%), Gaps = 30/188 (15%)

Query: 538  LEAELEHLRQALEGGLDTKEAKEKFLHEV--VKMRVKQEE-KLSAALQ-AKRSL-HQELE 592
            L+ E ++L+Q +    +      K +HE+  +K +V+QE+ +L AAL+ A+ SL H+E +
Sbjct: 1504 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563

Query: 593  FLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDK 652
             LR+  +            ++ E++R  AE ++++ +   + +R+   ++    A +  +
Sbjct: 1564 ILRIQLE---------LNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSR 1614

Query: 653  GCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLRE--------REAREHLEKVVK- 703
              +A RL+ K    + +++++L HA     ++ A+ LR         ++ + HL+  ++ 
Sbjct: 1615 N-DAIRLKKKMEGDLNEMEIQLNHA----NRMAAEALRNYRNTQGILKDTQIHLDDALRS 1669

Query: 704  --ELQEQL 709
              +L+EQL
Sbjct: 1670 QEDLKEQL 1677



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 42/186 (22%), Positives = 81/186 (43%), Gaps = 19/186 (10%)

Query: 553  LDTKEA--------KEKFLHEVVKMRVKQEEKL---SAALQAKRSLHQELEFLRVAKKEK 601
            LD KEA        K+ F  ++ +++ + EE++   +A   A +S   + + LR    E+
Sbjct: 1297 LDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLR----EQ 1352

Query: 602  LREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRA 661
              E  E+K  L++ + +   E  +   +     ++   ELE+A++ ++  +   A     
Sbjct: 1353 YEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK-KLAQRLQAAEEHVE 1411

Query: 662  KYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGSE 721
              +A+   L+   Q  + + E L  D+ R   A   L+K  +   + L   A  +    E
Sbjct: 1412 AVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL---AEWKQKCEE 1468

Query: 722  GAAELE 727
              AELE
Sbjct: 1469 THAELE 1474



 Score = 33.5 bits (75), Expect = 0.72
 Identities = 46/226 (20%), Positives = 95/226 (42%), Gaps = 42/226 (18%)

Query: 538  LEAELEHLR----QALEGGLDTKEA-KEKFLHEVVKMRVKQEEKLSAALQAKRS--LHQE 590
            +E +L H      +AL    +T+   K+  +H    +R +++ K   A+  +R+  L  E
Sbjct: 1631 MEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAE 1690

Query: 591  LEFLRVA----------KKEKLREATE--------------AKRNLRKEIERLRAENEKK 626
            +E LR             +++L +A+E               K+ L  +I +++ E E  
Sbjct: 1691 IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDI 1750

Query: 627  MKEANESRLRLKRELEQARQ-----ARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
            ++EA  +  + K+ +  A        +  D      R++      ++DLQ++L  AE   
Sbjct: 1751 LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAE--- 1807

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
               +  L   ++  + LE  V+EL+ ++    +  A   +G  + E
Sbjct: 1808 ---QLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHE 1850



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 34/169 (20%), Positives = 74/169 (43%), Gaps = 16/169 (9%)

Query: 538  LEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAA-----LQAKRSLHQELE 592
            L+A +E L + +E    ++   EK   ++ +   +  E+L  A      Q + +  +E E
Sbjct: 1117 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1176

Query: 593  FLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDK 652
            F ++  +  L EAT         + +  A++  ++ E  ++  R+K++LE+ +     + 
Sbjct: 1177 FQKM--RRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEI 1234

Query: 653  GCEAGRLRA---------KYSAQIEDLQVKLQHAEADREQLRADLLRER 692
               A  +           K    +ED   +L+  E ++++L  DL  +R
Sbjct: 1235 DDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQR 1283



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 40/187 (21%), Positives = 81/187 (43%), Gaps = 38/187 (20%)

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKM--RVKQEEKLSAALQA-KRSLHQELE 592
            S ++ E+E +   L+   + +E  +K + +   M   +K+E+  SA L+  K+++ Q ++
Sbjct: 1741 SQMQGEMEDI---LQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797

Query: 593  FLRV-----------AKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKREL 641
             L++             K+++++     R L  E+E  +  N + +K   +   R+K   
Sbjct: 1798 DLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELT 1857

Query: 642  EQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQ--------HAEADREQLRADLLRERE 693
             Q  + R             K   +++DL  KLQ         AE   EQ   +L + R+
Sbjct: 1858 YQTEEDR-------------KNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRK 1904

Query: 694  AREHLEK 700
             +  LE+
Sbjct: 1905 LQHELEE 1911


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 50/208 (24%), Positives = 96/208 (46%), Gaps = 14/208 (6%)

Query: 532  ADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQEL 591
            A+   GL       RQ LE  LD  +A+EK++ E+  +R   E +L+   +  +S  +EL
Sbjct: 1448 AEENRGLGERANLGRQFLEVELD--QAREKYVQELAAVRADAETRLAEVQREAQSTAREL 1505

Query: 592  EFL-------RVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRL-----KR 639
            E +       +V   E+ +   E ++ L  ++E+L     ++ K+  E   +L       
Sbjct: 1506 EVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQAS 1565

Query: 640  ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLE 699
            +++Q +   V  +G E+ +   +  AQ+ +LQ +L   E   E  +  + + +   +  +
Sbjct: 1566 KVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKK 1625

Query: 700  KVVKELQEQLWPRARPEAAGSEGAAELE 727
            +  +ELQEQL    + +    E  AE E
Sbjct: 1626 QQNQELQEQLRSLEQLQKENKELRAEAE 1653



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 50/210 (23%), Positives = 97/210 (46%), Gaps = 23/210 (10%)

Query: 538 LEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVA 597
           L++ + +L QA E      +A    L   V     +   L+A +Q +    QEL  L+  
Sbjct: 471 LQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQ---DQELAGLKQQ 527

Query: 598 KKEK-------LREATEAKRNLRKEIERLRA---ENEKKMKEANESRLRLKRELEQA--- 644
            KEK       L++  +A + LR ++E+L +   + E+++KE  E +   +++  Q    
Sbjct: 528 AKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLAT 587

Query: 645 ----RQARVCDKGCEAGRLRA---KYSAQIEDLQVKLQHAEADREQLRADLLREREAREH 697
               R+A + ++     +L A   + +A++E LQ +LQ A   R+  +  + + +  +  
Sbjct: 588 AAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAE 647

Query: 698 LEKVVKELQEQLWPRARPEAAGSEGAAELE 727
           L + V+ELQ  +    + +       AELE
Sbjct: 648 LSRKVEELQACVETARQEQHEAQAQVAELE 677



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 77/316 (24%), Positives = 130/316 (41%), Gaps = 64/316 (20%)

Query: 444 EPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPS 503
           + LAT  + R+  L          L  + A E++K ++ E+ ++ + +  +     +  S
Sbjct: 583 QQLATAAEEREASLRE----RDAALKQLEALEKEKAAKLEI-LQQQLQVANEARDSAQTS 637

Query: 504 FTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFL 563
            T +   K   S     L + V  A           AELE         L  +  ++K  
Sbjct: 638 VTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELE---------LQLRSEQQKAT 688

Query: 564 HEVVKMRVKQE-EKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAE 622
               K RV QE ++L   LQA   L + L+  + + +E+ R A +A    ++ I  L+AE
Sbjct: 689 E---KERVAQEKDQLQEQLQA---LKESLKVTKGSLEEEKRRAADALEEQQRCISELKAE 742

Query: 623 NEKKMKEANESRLRLKRELEQARQARVCDKGCEA--GRLRAKYSAQIEDLQVKL------ 674
               +++        KRE ++  + R   KG EA   +L   + A+ E L+ +L      
Sbjct: 743 TRSLVEQH-------KRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAA 795

Query: 675 QH-AEADREQLRADLLRERE----------------------AREHLEKVVKELQEQLWP 711
           QH AE++ EQL  ++   RE                       +E  EK  +ELQE    
Sbjct: 796 QHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQE---- 851

Query: 712 RARPEAAGSEGAAELE 727
            A+ + AG E  +EL+
Sbjct: 852 -AKEKVAGIESHSELQ 866



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/192 (26%), Positives = 86/192 (44%), Gaps = 19/192 (9%)

Query: 536  SGLEAELEHL-RQALEGGLDTKEAKEKFLHEVVKMRVKQE-----------------EKL 577
            S LE E+  L RQ LE   ++KE K   + E  K +  +E                 E+ 
Sbjct: 1228 SSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERS 1287

Query: 578  SAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKM-KEANESRLR 636
            SA  +  +SL +E E  RVA +   +E T       +  + L+A  EK   KE   S L+
Sbjct: 1288 SALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQ 1347

Query: 637  LKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREARE 696
            L+    QA  + +        +L+A+ +A  +  + +L+ ++     LRA+LLR +    
Sbjct: 1348 LEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELG 1407

Query: 697  HLEKVVKELQEQ 708
             L  + +++ EQ
Sbjct: 1408 ELIPLRQKVAEQ 1419



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 51/237 (21%), Positives = 98/237 (41%), Gaps = 31/237 (13%)

Query: 477 DKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPS 536
           +K + + +E +  EE      SL+     +    +DL +  ++        +    D   
Sbjct: 266 EKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSF 325

Query: 537 GLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRV 596
            L     HL+Q  +   +  E   K   E ++ + + E++LSAALQ K+ L ++ E L  
Sbjct: 326 KLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEIL-- 383

Query: 597 AKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEA 656
             + KL +       L + + +L+    ++  E     L+L+   ++A            
Sbjct: 384 --QGKLSQ-------LEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEA------------ 422

Query: 657 GRLRAKYSAQIEDLQVKLQHAEADREQLRADLLRER----EAREHLEKVVKELQEQL 709
               A  +A    LQ +++  E +R Q  A LL ER    E ++ L  ++ +LQ  +
Sbjct: 423 ----ATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSI 475



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 68/288 (23%), Positives = 113/288 (39%), Gaps = 54/288 (18%)

Query: 475  EEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADA 534
            +E K+  A +E  S  + +   + L+      + + + +     RA   A  D +   + 
Sbjct: 850  QEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLA-DDLSTLQEK 908

Query: 535  PSGLEAELEHLRQAL-EGGLDTKEAKEKFLHEVVKMRVKQEEKLS-----------AALQ 582
             +    E+  L   + + G   + A  + + E  +   +Q E L            AALQ
Sbjct: 909  MAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQ 968

Query: 583  AKR----SLHQELEFLRVAKKEKLREATEAKRNLRKEIERL-----RAENEKKMKEANES 633
            A       +  ELE LR A  E   +  E +    +E+ RL     RA+ +  +++A  +
Sbjct: 969  AMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARA 1028

Query: 634  RL--RLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADL--L 689
             L  RL+  L + R                    +   LQ  L HA  ++E    +L  L
Sbjct: 1029 ELEMRLQNALNEQR-------------------VEFATLQEALAHALTEKEGKDQELAKL 1069

Query: 690  REREAR-----EHLEKVVKELQEQLWPRARPEAAG----SEGAAELEP 728
            R  EA      E L + VK+L+EQL  + +  A+G    SE A   EP
Sbjct: 1070 RGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117



 Score = 38.9 bits (89), Expect = 0.017
 Identities = 73/306 (23%), Positives = 120/306 (39%), Gaps = 33/306 (10%)

Query: 437  AAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDS---EAEVEVESREEFT 493
            A+ S A    A  T+P   KL        +        +E  DS     E E  SR E  
Sbjct: 1102 ASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERD 1161

Query: 494  SSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAA-------PADAPSGLEAELEHLR 546
            S+L +L          A++LG   + AL SA  + AA        + A    +A++   R
Sbjct: 1162 SALETLQGQL---EEKAQELGHSQS-ALASAQRELAAFRTKVQDHSKAEDEWKAQVARGR 1217

Query: 547  QALEGG---LDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELE----FLRVAKK 599
            Q  E     + + E +   L+  V  +  + ++L   + A+    Q+LE     L+    
Sbjct: 1218 QEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETA 1277

Query: 600  EKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRL 659
                 A E    LR+E++ LR E EK+   +   R  L  + E+A +      G E    
Sbjct: 1278 SNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEEL-----GQELKAW 1332

Query: 660  RAKYSAQIEDLQ-VKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAA 718
            + K+  + + L  ++L+H           L+ E    +HL + ++  Q     R R E  
Sbjct: 1333 QEKFFQKEQALSTLQLEHTSTQA------LVSELLPAKHLCQQLQAEQAAAEKRHREELE 1386

Query: 719  GSEGAA 724
             S+ AA
Sbjct: 1387 QSKQAA 1392



 Score = 38.5 bits (88), Expect = 0.022
 Identities = 38/169 (22%), Positives = 76/169 (44%), Gaps = 23/169 (13%)

Query: 532  ADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQEL 591
            AD+    + + + L+     G ++++  ++   ++ +++ +  +K  AA   K  + +  
Sbjct: 1559 ADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAK 1618

Query: 592  EFLRVAKKE--KLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARV 649
                  K++  +L+E   +   L+KE + LRAE E           RL  EL+QA     
Sbjct: 1619 THYDAKKQQNQELQEQLRSLEQLQKENKELRAEAE-----------RLGHELQQAGL--- 1664

Query: 650  CDKGCEAGRLRAKYSAQIEDLQVKLQHAEAD-----REQLRADLLRERE 693
              K  EA +     +AQ+  L+ ++ HA+       + Q+  D L+ RE
Sbjct: 1665 --KTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDALKSRE 1711



 Score = 38.1 bits (87), Expect = 0.029
 Identities = 54/284 (19%), Positives = 116/284 (40%), Gaps = 33/284 (11%)

Query: 439 VSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSE-AEVEVESREEFTSSLS 497
           +S+A E L   +Q    +LT         L  + A  + +D E A ++ +++E+      
Sbjct: 478 LSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQ 537

Query: 498 SLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKE 557
           +L           ++  S G R     +          S L+ + + L++  E    T++
Sbjct: 538 TLQQ---------QEQASQGLRHQVEQLS---------SSLKQKEQQLKEVAEKQEATRQ 579

Query: 558 AKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEI- 616
              + L    + R     +  AAL+   +L +E        +++L+ A EA+ + +  + 
Sbjct: 580 DHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVT 639

Query: 617 --ERLRAENEKKMKEANESRLRLKRELEQARQARVCD----------KGCEAGRLRAKYS 664
             +R +AE  +K++E  ++ +   R+ +   QA+V +          K  E  R+  +  
Sbjct: 640 QAQREKAELSRKVEEL-QACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKD 698

Query: 665 AQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQ 708
              E LQ   +  +  +  L  +  R  +A E  ++ + EL+ +
Sbjct: 699 QLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAE 742



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 49/211 (23%), Positives = 92/211 (43%), Gaps = 22/211 (10%)

Query: 515 SPGARALPSAVPDAAAPADAPSGLEA---ELEHLRQALEGGLDTKEAKEKFLHEVVKMRV 571
           +P      S  P+  +P    +  E    EL+ +  +  G      +    + ++++   
Sbjct: 154 APVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQ 213

Query: 572 KQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAK-RNLRKEIERLRAENEK----- 625
            Q  +L   L  +RS   ELE L +A+  KL    +A+   +++ I+RL   NEK     
Sbjct: 214 FQMRRLKKQLADERSNRDELE-LELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASP 272

Query: 626 -------KMKEANES-RLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHA 677
                  ++++ NES  +RL   L+Q +  +   +  +  R   + S +  DL  KL+  
Sbjct: 273 LEPKELEELRDKNESLTMRLHETLKQCQDLKT--EKSQMDRKINQLSEENGDLSFKLREF 330

Query: 678 EADREQLRADLLREREAREHLEKVVKELQEQ 708
            +  +QL+ D L E    EH +   + L++Q
Sbjct: 331 ASHLQQLQ-DALNEL-TEEHSKATQEWLEKQ 359



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 57/252 (22%), Positives = 103/252 (40%), Gaps = 40/252 (15%)

Query: 476  EDKDSEAEVEVESREEFTSSLSSLSSPSFTSSS--SAKDLGSPGARALPSAVPDA----- 528
            E+   E   + E  EE    L +     F      S   L     +AL S +  A     
Sbjct: 1309 ENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQ 1368

Query: 529  ---AAPADAPSGLEAELEHLRQALEGGLDTKEAK-EKFLHEVVKMRVK--QEEKLSAALQ 582
               A  A A      ELE  +QA  GGL  +  + ++ L E++ +R K  ++E+ +  L+
Sbjct: 1369 QLQAEQAAAEKRHREELEQSKQAA-GGLRAELLRAQRELGELIPLRQKVAEQERTAQQLR 1427

Query: 583  AKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKE-ANESRLRLKREL 641
            A+++ + E                  + ++ K+   L AE  + + E AN  R  L+ EL
Sbjct: 1428 AEKASYAE------------------QLSMLKKAHGLLAEENRGLGERANLGRQFLEVEL 1469

Query: 642  EQARQARV-------CDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREA 694
            +QAR+  V        D       ++ +  +   +L+V     E  + ++  +  R +E 
Sbjct: 1470 DQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEE 1529

Query: 695  REHLEKVVKELQ 706
            R+ L   V++L+
Sbjct: 1530 RQKLTAQVEQLE 1541



 Score = 33.1 bits (74), Expect = 0.94
 Identities = 41/174 (23%), Positives = 72/174 (41%), Gaps = 16/174 (9%)

Query: 539 EAELEHLRQALEGGL---DTKEAK-EKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFL 594
           +AE E LR+ L   +    T E++ E+ + EV   R + E+      Q      ++L  L
Sbjct: 779 QAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTL 838

Query: 595 RVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGC 654
           +   ++  +E  EAK  +         +  ++  E  E    L R L+Q ++  V     
Sbjct: 839 KEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEV----- 893

Query: 655 EAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQ 708
                  K +  +  LQ K+  A   +E  R + L  R+A E  E   +EL ++
Sbjct: 894 ----RAQKLADDLSTLQEKM--AATSKEVARLETL-VRKAGEQQETASRELVKE 940


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 103/447 (23%), Positives = 172/447 (38%), Gaps = 72/447 (16%)

Query: 319 RRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLAGSSNKSLGCVHPRQRLSA 378
           ++V     EPP    P     ++  P   E +  +SW       +N +     P  + +A
Sbjct: 369 QKVGSEQKEPPEEAEP----VAAAEPEVPENNGNNSWPHNDTEIANST-----PNPKPAA 419

Query: 379 FRPWSPAVSASEKELS----PHLPALIRDSFYSYKSF-----ETAVAPNVALAPPAQQKV 429
             P +P+    E +      P  P        SYK       E     +  L PP  +  
Sbjct: 420 SSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK-- 477

Query: 430 VSSPPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDSEAEVEVESR 489
             S PC A  S+   PL T     +R   + TP    T AP +  +        + ++ +
Sbjct: 478 TPSSPCPA--SKVVRPLRTFLHTVQRNQMLMTP----TSAPRSVMKSFIKRNTPLRMDPK 531

Query: 490 EEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQAL 549
           E+    L +L           + +     R L                    +E +++  
Sbjct: 532 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK 591

Query: 550 EGGLD---------TKEAKEKFLHEV-------------VKMRVKQEEKLSAA--LQAKR 585
           +  ++         T++AKE+ L E              V+ R KQEE+      LQ + 
Sbjct: 592 KKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEE 651

Query: 586 SLHQELEFLRVAKKE---KLREATEAKR------NLRKEIERLRAENEKKMKEANESRLR 636
              +  E L+  K+E   +LR+A EAKR        R+E ER   E E++ +E  E   R
Sbjct: 652 EERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER--REQERREQERREQERR 709

Query: 637 LKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREARE 696
                EQ RQ    ++  E  RL+A+   Q  +  ++LQ     +EQL+ +L  +++  E
Sbjct: 710 -----EQERQLAEQERRREQERLQAERELQEREKALRLQ-----KEQLQRELEEKKKKEE 759

Query: 697 HLEKVVKELQEQLWPRARPEAAGSEGA 723
                 ++LQE+   +A+ EAAG+  A
Sbjct: 760 QQRLAERQLQEEQEKKAK-EAAGASKA 785


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 65/267 (24%), Positives = 119/267 (44%), Gaps = 41/267 (15%)

Query: 473  APEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPA 532
            A E ++ +E E  +E + +   + +   + +      AK+L     R     V    A  
Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQA---EREAKELQQ---RMQEEVVRREEAAV 1409

Query: 533  DAPS---GLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEK-----LSAALQAK 584
            DA      ++ EL+ LRQ+ E  +  K A++    E  ++R+++E +     L A  + +
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRA----ENEKKMKEANESRLRLKRE 640
                 EL+ LR     +  EA   KR  ++E ERLR     E+++K +   E   R+K E
Sbjct: 1469 GGAEGELQALRA----RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524

Query: 641  LEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEK 700
             E AR+ +   +  E               +++LQ  EA+R   +A++ R R+ +  LE 
Sbjct: 1525 AEAAREKQRALQALE---------------ELRLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 701  VVKELQEQLWPRARPEAAGSEGAAELE 727
              +  + +L  +    A+ +E  A+LE
Sbjct: 1570 AQRSAEAELQSK---RASFAEKTAQLE 1593



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 58/215 (26%), Positives = 100/215 (46%), Gaps = 39/215 (18%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            E ELE  RQ  EG    + A E+   E++++R + E+      Q ++ L +EL  L+   
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQ---ELIRLRAETEQ----GEQQRQLLEEELARLQ--- 1740

Query: 599  KEKLREATEAKRNLRKEIERLRAENE----KKMKEANESRLRLKRELE--QARQARVCDK 652
              +   AT+ ++ L  E+ ++RAE E     K +   ESR   ++  +  +A   R  + 
Sbjct: 1741 -REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799

Query: 653  GCEAGRLR-----AKYSAQIEDLQVKLQHAEADR---EQLRA------------DLLRER 692
              EA RLR     AK   Q+ +     Q AEA+R   E+L A              L+E+
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859

Query: 693  EAREHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            EA    E++ +  +++ + R R E   ++  A++E
Sbjct: 1860 EAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE 1892



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 70/272 (25%), Positives = 120/272 (44%), Gaps = 24/272 (8%)

Query: 466  ETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAV 525
            E L      E  +  +AEVE+ SR +  +  +     +  +    +       R L  A 
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556

Query: 526  PDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKM-RVKQEEKLSAAL--- 581
             + A        ++  LE  +++ E  L +K A   F  +  ++ R  QEE ++ A    
Sbjct: 1557 VERARQ------VQVALETAQRSAEAELQSKRAS--FAEKTAQLERSLQEEHVAVAQLRE 1608

Query: 582  QAKRSLHQELEFLRV---AKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLK 638
            +A+R   Q+ E  R    A++E  R   +A   LR    RL+AE   + K   ++    +
Sbjct: 1609 EAERRAQQQAEAERAREEAERELERWQLKANEALRL---RLQAEEVAQQKSLAQAEAEKQ 1665

Query: 639  RELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRA---DLLREREAR 695
            +E E  R+AR   K  E   +R +  A+ ++L+ + Q AE   +Q  A   +L+R R   
Sbjct: 1666 KE-EAEREARRRGK-AEEQAVRQRELAE-QELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722

Query: 696  EHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            E  E+  + L+E+L    R  AA ++   ELE
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELE 1754



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 37/158 (23%), Positives = 77/158 (48%), Gaps = 21/158 (13%)

Query: 568  KMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKM 627
            + R ++ E+L+    A     Q  E    AK +  REA E ++ +++E+ R     E+  
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR----REEAA 1408

Query: 628  KEANESRLRLKRELEQARQARVCD--------KGCEAGRLRAKYSAQIEDLQVKLQH--- 676
             +A + +  ++ EL+Q RQ+   +        +  E  RLR +   ++  LQ++      
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 677  --AEADREQLRADL----LREREAREHLEKVVKELQEQ 708
              AE + + LRA       ++R+A+E  E++ +++Q++
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 26/190 (13%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            EAE    +QA     + + A+E+   E+ + ++K  E L   LQA+    Q+      A+
Sbjct: 1609 EAERRAQQQA-----EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663

Query: 599  KEKLREATEAKRNLRKEIERLR--------AENEKKMKE--------ANESRLRLKRELE 642
            K+K     EA+R  + E + +R         E ++++ E        A +  +RL+ E E
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723

Query: 643  QARQARVCDKGCEAGRLRAKYSA---QIEDLQVKLQHAEADREQLRADLLR-EREAREHL 698
            Q  Q R   +  E  RL+ + +A   + ++L+ +L    A+ E L A   R E E+R   
Sbjct: 1724 QGEQQRQLLEE-ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782

Query: 699  EKVVKELQEQ 708
            EK  + L+ +
Sbjct: 1783 EKSKQRLEAE 1792



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/182 (28%), Positives = 83/182 (45%), Gaps = 21/182 (11%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRS 586
            DA    +A + LE E E L+Q         EAK   L       V+QE+ L      ++S
Sbjct: 2444 DAERLREAIAELEREKEKLQQ---------EAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494

Query: 587  LHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQ 646
               E + L   ++E+  E  +AK      +E+L  +   K ++  E + R ++++EQ RQ
Sbjct: 2495 FLSEKDSL--LQRERFIEQEKAK------LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2546

Query: 647  ARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQ 706
              V     EA R + +    +   Q +LQ  E  R Q + +LL E   R  L + ++ L+
Sbjct: 2547 RLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQ-QEELLAEENQR--LREQLQLLE 2602

Query: 707  EQ 708
            EQ
Sbjct: 2603 EQ 2604



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 94/449 (20%), Positives = 171/449 (38%), Gaps = 51/449 (11%)

Query: 295  EEQARLGRCLDDVKEKFDYGN----KYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKD 350
            EE ARL    ++ K +         + +    RV +E  A+I   T   +    A  EK+
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860

Query: 351  KPSSWLRTLAGSSN------KSLGCVHP---RQRLSAFRPWSPAVSASEKELSPHLPALI 401
              +  LR LA          +     H     +RL+  R       AS+ EL      L+
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR------KASDSELERQ-KGLV 1913

Query: 402  RDSFYSYKSFETAV-APNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQP-----RKR 455
             D+    +  E  + A   +    A  K           S A + L +  Q      R+R
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973

Query: 456  KLTVDTPG----APETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSS-PSFTSSSSA 510
            +L  +       A E +    A EE+   + +  +E  E   + +             SA
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033

Query: 511  KDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDT----KEAKEKFLHEV 566
            + L      A      +  A A A    E EL+   Q  +  LD      EA  +   E 
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093

Query: 567  VKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEK- 625
             + RV+ E +   A Q++R + +E E L    K+   E  +A+   +   E+LR E E+ 
Sbjct: 2094 EEARVQAERE---AAQSRRQV-EEAERL----KQSAEEQAQARAQAQAAAEKLRKEAEQE 2145

Query: 626  --KMKEANESRLRLKR--ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
              +  +A ++ LR K+  + E  +  +  +   +  R +A+   ++  L+++L+  +  +
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLEETDHQK 2202

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLW 710
              L  +L R +       +   +++E+L+
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELF 2231



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 57/229 (24%), Positives = 101/229 (44%), Gaps = 30/229 (13%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTK---EAKEKFLHEVVKMRVKQE----EKLSA 579
            +AAA       LEAEL  +R  +E  L +K   E + +   E  K R++ E     +L+ 
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801

Query: 580  ALQAKRSLHQELEFLR-VAKKEKLREATEAKRNLRKEIERL-----------------RA 621
                 R+L +E +  R +A+++  R+  EA+R L +++  +                  A
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861

Query: 622  ENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
            ENE+  + A +   + +R  EQA Q +  D      +LR    +++E  +  ++     R
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAG---SEGAAELE 727
             Q+  ++L  + + E       EL+ +L  R R  A     S+  AELE
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELE 1968



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 62/229 (27%), Positives = 93/229 (40%), Gaps = 60/229 (26%)

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVV-KMRVKQEE--KLSAALQ--------AK 584
            S L+A +E   +AL   L  K+  ++FL E   KM+   EE  +LS A Q        A+
Sbjct: 2241 SKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIE--------------RLRAENEKKMKEA 630
              L Q+        KEK++   EA R L+ E E              RL+ + E+  ++ 
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357

Query: 631  NESRLRLKRELEQARQARVCDKGCEAGRLRAK-----------------YSAQIEDLQVK 673
             E     +R LE  RQ R  +   EA RL+ +                 +  Q E++  K
Sbjct: 2358 AEETQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416

Query: 674  L--------------QHAEADREQLRADLLREREAREHLEKVVKELQEQ 708
            L              Q  E  R+Q   D  R REA   LE+  ++LQ++
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 65/267 (24%), Positives = 119/267 (44%), Gaps = 41/267 (15%)

Query: 473  APEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPA 532
            A E ++ +E E  +E + +   + +   + +      AK+L     R     V    A  
Sbjct: 1360 AEERERLAEVEAALEKQRQLAEAHAQAKAQA---EREAKELQQ---RMQEEVVRREEAAV 1413

Query: 533  DAPS---GLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEK-----LSAALQAK 584
            DA      ++ EL+ LRQ+ E  +  K A++    E  ++R+++E +     L A  + +
Sbjct: 1414 DAQQQKRSIQEELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1472

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRA----ENEKKMKEANESRLRLKRE 640
                 EL+ LR     +  EA   KR  ++E ERLR     E+++K +   E   R+K E
Sbjct: 1473 GGAEGELQALRA----RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1528

Query: 641  LEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEK 700
             E AR+ +   +  E               +++LQ  EA+R   +A++ R R+ +  LE 
Sbjct: 1529 AEAAREKQRALQALE---------------ELRLQAEEAERRLRQAEVERARQVQVALET 1573

Query: 701  VVKELQEQLWPRARPEAAGSEGAAELE 727
              +  + +L  +    A+ +E  A+LE
Sbjct: 1574 AQRSAEAELQSK---RASFAEKTAQLE 1597



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 58/215 (26%), Positives = 100/215 (46%), Gaps = 39/215 (18%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            E ELE  RQ  EG    + A E+   E++++R + E+      Q ++ L +EL  L+   
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQ---ELIRLRAETEQ----GEQQRQLLEEELARLQ--- 1744

Query: 599  KEKLREATEAKRNLRKEIERLRAENE----KKMKEANESRLRLKRELE--QARQARVCDK 652
              +   AT+ ++ L  E+ ++RAE E     K +   ESR   ++  +  +A   R  + 
Sbjct: 1745 -REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1803

Query: 653  GCEAGRLR-----AKYSAQIEDLQVKLQHAEADR---EQLRA------------DLLRER 692
              EA RLR     AK   Q+ +     Q AEA+R   E+L A              L+E+
Sbjct: 1804 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1863

Query: 693  EAREHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            EA    E++ +  +++ + R R E   ++  A++E
Sbjct: 1864 EAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE 1896



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 70/272 (25%), Positives = 120/272 (44%), Gaps = 24/272 (8%)

Query: 466  ETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAV 525
            E L      E  +  +AEVE+ SR +  +  +     +  +    +       R L  A 
Sbjct: 1501 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1560

Query: 526  PDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKM-RVKQEEKLSAAL--- 581
             + A        ++  LE  +++ E  L +K A   F  +  ++ R  QEE ++ A    
Sbjct: 1561 VERARQ------VQVALETAQRSAEAELQSKRAS--FAEKTAQLERSLQEEHVAVAQLRE 1612

Query: 582  QAKRSLHQELEFLRV---AKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLK 638
            +A+R   Q+ E  R    A++E  R   +A   LR    RL+AE   + K   ++    +
Sbjct: 1613 EAERRAQQQAEAERAREEAERELERWQLKANEALRL---RLQAEEVAQQKSLAQAEAEKQ 1669

Query: 639  RELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRA---DLLREREAR 695
            +E E  R+AR   K  E   +R +  A+ ++L+ + Q AE   +Q  A   +L+R R   
Sbjct: 1670 KE-EAEREARRRGK-AEEQAVRQRELAE-QELEKQRQLAEGTAQQRLAAEQELIRLRAET 1726

Query: 696  EHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            E  E+  + L+E+L    R  AA ++   ELE
Sbjct: 1727 EQGEQQRQLLEEELARLQREAAAATQKRQELE 1758



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 37/158 (23%), Positives = 77/158 (48%), Gaps = 21/158 (13%)

Query: 568  KMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKM 627
            + R ++ E+L+    A     Q  E    AK +  REA E ++ +++E+ R     E+  
Sbjct: 1357 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR----REEAA 1412

Query: 628  KEANESRLRLKRELEQARQARVCD--------KGCEAGRLRAKYSAQIEDLQVKLQH--- 676
             +A + +  ++ EL+Q RQ+   +        +  E  RLR +   ++  LQ++      
Sbjct: 1413 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1472

Query: 677  --AEADREQLRADL----LREREAREHLEKVVKELQEQ 708
              AE + + LRA       ++R+A+E  E++ +++Q++
Sbjct: 1473 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 26/190 (13%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            EAE    +QA     + + A+E+   E+ + ++K  E L   LQA+    Q+      A+
Sbjct: 1613 EAERRAQQQA-----EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1667

Query: 599  KEKLREATEAKRNLRKEIERLR--------AENEKKMKE--------ANESRLRLKRELE 642
            K+K     EA+R  + E + +R         E ++++ E        A +  +RL+ E E
Sbjct: 1668 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1727

Query: 643  QARQARVCDKGCEAGRLRAKYSA---QIEDLQVKLQHAEADREQLRADLLR-EREAREHL 698
            Q  Q R   +  E  RL+ + +A   + ++L+ +L    A+ E L A   R E E+R   
Sbjct: 1728 QGEQQRQLLEE-ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1786

Query: 699  EKVVKELQEQ 708
            EK  + L+ +
Sbjct: 1787 EKSKQRLEAE 1796



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/182 (28%), Positives = 83/182 (45%), Gaps = 21/182 (11%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRS 586
            DA    +A + LE E E L+Q         EAK   L       V+QE+ L      ++S
Sbjct: 2448 DAERLREAIAELEREKEKLQQ---------EAKLLQLKSEEMQTVQQEQLLQETQALQQS 2498

Query: 587  LHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQ 646
               E + L   ++E+  E  +AK      +E+L  +   K ++  E + R ++++EQ RQ
Sbjct: 2499 FLSEKDSL--LQRERFIEQEKAK------LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2550

Query: 647  ARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQ 706
              V     EA R + +    +   Q +LQ  E  R Q + +LL E   R  L + ++ L+
Sbjct: 2551 RLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQ-QEELLAEENQR--LREQLQLLE 2606

Query: 707  EQ 708
            EQ
Sbjct: 2607 EQ 2608



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 94/449 (20%), Positives = 171/449 (38%), Gaps = 51/449 (11%)

Query: 295  EEQARLGRCLDDVKEKFDYGN----KYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKD 350
            EE ARL    ++ K +         + +    RV +E  A+I   T   +    A  EK+
Sbjct: 1805 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1864

Query: 351  KPSSWLRTLAGSSN------KSLGCVHP---RQRLSAFRPWSPAVSASEKELSPHLPALI 401
              +  LR LA          +     H     +RL+  R       AS+ EL      L+
Sbjct: 1865 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR------KASDSELERQ-KGLV 1917

Query: 402  RDSFYSYKSFETAV-APNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQP-----RKR 455
             D+    +  E  + A   +    A  K           S A + L +  Q      R+R
Sbjct: 1918 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1977

Query: 456  KLTVDTPG----APETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSS-PSFTSSSSA 510
            +L  +       A E +    A EE+   + +  +E  E   + +             SA
Sbjct: 1978 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2037

Query: 511  KDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDT----KEAKEKFLHEV 566
            + L      A      +  A A A    E EL+   Q  +  LD      EA  +   E 
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2097

Query: 567  VKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEK- 625
             + RV+ E +   A Q++R + +E E L    K+   E  +A+   +   E+LR E E+ 
Sbjct: 2098 EEARVQAERE---AAQSRRQV-EEAERL----KQSAEEQAQARAQAQAAAEKLRKEAEQE 2149

Query: 626  --KMKEANESRLRLKR--ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
              +  +A ++ LR K+  + E  +  +  +   +  R +A+   ++  L+++L+  +  +
Sbjct: 2150 AARRAQAEQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLEETDHQK 2206

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLW 710
              L  +L R +       +   +++E+L+
Sbjct: 2207 NLLDEELQRLKAEATEAARQRSQVEEELF 2235



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 57/229 (24%), Positives = 101/229 (44%), Gaps = 30/229 (13%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTK---EAKEKFLHEVVKMRVKQE----EKLSA 579
            +AAA       LEAEL  +R  +E  L +K   E + +   E  K R++ E     +L+ 
Sbjct: 1746 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805

Query: 580  ALQAKRSLHQELEFLR-VAKKEKLREATEAKRNLRKEIERL-----------------RA 621
                 R+L +E +  R +A+++  R+  EA+R L +++  +                  A
Sbjct: 1806 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1865

Query: 622  ENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
            ENE+  + A +   + +R  EQA Q +  D      +LR    +++E  +  ++     R
Sbjct: 1866 ENERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQR 1924

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAG---SEGAAELE 727
             Q+  ++L  + + E       EL+ +L  R R  A     S+  AELE
Sbjct: 1925 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELE 1972



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 62/229 (27%), Positives = 93/229 (40%), Gaps = 60/229 (26%)

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVV-KMRVKQEE--KLSAALQ--------AK 584
            S L+A +E   +AL   L  K+  ++FL E   KM+   EE  +LS A Q        A+
Sbjct: 2245 SKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2302

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIE--------------RLRAENEKKMKEA 630
              L Q+        KEK++   EA R L+ E E              RL+ + E+  ++ 
Sbjct: 2303 EDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361

Query: 631  NESRLRLKRELEQARQARVCDKGCEAGRLRAK-----------------YSAQIEDLQVK 673
             E     +R LE  RQ R  +   EA RL+ +                 +  Q E++  K
Sbjct: 2362 AEETQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2420

Query: 674  L--------------QHAEADREQLRADLLREREAREHLEKVVKELQEQ 708
            L              Q  E  R+Q   D  R REA   LE+  ++LQ++
Sbjct: 2421 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2469


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 65/267 (24%), Positives = 119/267 (44%), Gaps = 41/267 (15%)

Query: 473  APEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPA 532
            A E ++ +E E  +E + +   + +   + +      AK+L     R     V    A  
Sbjct: 1356 AEERERLAEVEAALEKQRQLAEAHAQAKAQA---EREAKELQQ---RMQEEVVRREEAAV 1409

Query: 533  DAPS---GLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEK-----LSAALQAK 584
            DA      ++ EL+ LRQ+ E  +  K A++    E  ++R+++E +     L A  + +
Sbjct: 1410 DAQQQKRSIQEELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRA----ENEKKMKEANESRLRLKRE 640
                 EL+ LR     +  EA   KR  ++E ERLR     E+++K +   E   R+K E
Sbjct: 1469 GGAEGELQALRA----RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1524

Query: 641  LEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEK 700
             E AR+ +   +  E               +++LQ  EA+R   +A++ R R+ +  LE 
Sbjct: 1525 AEAAREKQRALQALE---------------ELRLQAEEAERRLRQAEVERARQVQVALET 1569

Query: 701  VVKELQEQLWPRARPEAAGSEGAAELE 727
              +  + +L  +    A+ +E  A+LE
Sbjct: 1570 AQRSAEAELQSK---RASFAEKTAQLE 1593



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 58/215 (26%), Positives = 100/215 (46%), Gaps = 39/215 (18%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            E ELE  RQ  EG    + A E+   E++++R + E+      Q ++ L +EL  L+   
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQ---ELIRLRAETEQ----GEQQRQLLEEELARLQ--- 1740

Query: 599  KEKLREATEAKRNLRKEIERLRAENE----KKMKEANESRLRLKRELE--QARQARVCDK 652
              +   AT+ ++ L  E+ ++RAE E     K +   ESR   ++  +  +A   R  + 
Sbjct: 1741 -REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1799

Query: 653  GCEAGRLR-----AKYSAQIEDLQVKLQHAEADR---EQLRA------------DLLRER 692
              EA RLR     AK   Q+ +     Q AEA+R   E+L A              L+E+
Sbjct: 1800 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1859

Query: 693  EAREHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            EA    E++ +  +++ + R R E   ++  A++E
Sbjct: 1860 EAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE 1892



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 70/272 (25%), Positives = 120/272 (44%), Gaps = 24/272 (8%)

Query: 466  ETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAV 525
            E L      E  +  +AEVE+ SR +  +  +     +  +    +       R L  A 
Sbjct: 1497 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556

Query: 526  PDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKM-RVKQEEKLSAAL--- 581
             + A        ++  LE  +++ E  L +K A   F  +  ++ R  QEE ++ A    
Sbjct: 1557 VERARQ------VQVALETAQRSAEAELQSKRAS--FAEKTAQLERSLQEEHVAVAQLRE 1608

Query: 582  QAKRSLHQELEFLRV---AKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLK 638
            +A+R   Q+ E  R    A++E  R   +A   LR    RL+AE   + K   ++    +
Sbjct: 1609 EAERRAQQQAEAERAREEAERELERWQLKANEALRL---RLQAEEVAQQKSLAQAEAEKQ 1665

Query: 639  RELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRA---DLLREREAR 695
            +E E  R+AR   K  E   +R +  A+ ++L+ + Q AE   +Q  A   +L+R R   
Sbjct: 1666 KE-EAEREARRRGK-AEEQAVRQRELAE-QELEKQRQLAEGTAQQRLAAEQELIRLRAET 1722

Query: 696  EHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            E  E+  + L+E+L    R  AA ++   ELE
Sbjct: 1723 EQGEQQRQLLEEELARLQREAAAATQKRQELE 1754



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 37/158 (23%), Positives = 77/158 (48%), Gaps = 21/158 (13%)

Query: 568  KMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKM 627
            + R ++ E+L+    A     Q  E    AK +  REA E ++ +++E+ R     E+  
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR----REEAA 1408

Query: 628  KEANESRLRLKRELEQARQARVCD--------KGCEAGRLRAKYSAQIEDLQVKLQH--- 676
             +A + +  ++ EL+Q RQ+   +        +  E  RLR +   ++  LQ++      
Sbjct: 1409 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1468

Query: 677  --AEADREQLRADL----LREREAREHLEKVVKELQEQ 708
              AE + + LRA       ++R+A+E  E++ +++Q++
Sbjct: 1469 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 26/190 (13%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            EAE    +QA     + + A+E+   E+ + ++K  E L   LQA+    Q+      A+
Sbjct: 1609 EAERRAQQQA-----EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1663

Query: 599  KEKLREATEAKRNLRKEIERLR--------AENEKKMKE--------ANESRLRLKRELE 642
            K+K     EA+R  + E + +R         E ++++ E        A +  +RL+ E E
Sbjct: 1664 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1723

Query: 643  QARQARVCDKGCEAGRLRAKYSA---QIEDLQVKLQHAEADREQLRADLLR-EREAREHL 698
            Q  Q R   +  E  RL+ + +A   + ++L+ +L    A+ E L A   R E E+R   
Sbjct: 1724 QGEQQRQLLEE-ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1782

Query: 699  EKVVKELQEQ 708
            EK  + L+ +
Sbjct: 1783 EKSKQRLEAE 1792



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/182 (28%), Positives = 83/182 (45%), Gaps = 21/182 (11%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRS 586
            DA    +A + LE E E L+Q         EAK   L       V+QE+ L      ++S
Sbjct: 2444 DAERLREAIAELEREKEKLQQ---------EAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494

Query: 587  LHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQ 646
               E + L   ++E+  E  +AK      +E+L  +   K ++  E + R ++++EQ RQ
Sbjct: 2495 FLSEKDSL--LQRERFIEQEKAK------LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2546

Query: 647  ARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQ 706
              V     EA R + +    +   Q +LQ  E  R Q + +LL E   R  L + ++ L+
Sbjct: 2547 RLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQ-QEELLAEENQR--LREQLQLLE 2602

Query: 707  EQ 708
            EQ
Sbjct: 2603 EQ 2604



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 94/449 (20%), Positives = 171/449 (38%), Gaps = 51/449 (11%)

Query: 295  EEQARLGRCLDDVKEKFDYGN----KYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKD 350
            EE ARL    ++ K +         + +    RV +E  A+I   T   +    A  EK+
Sbjct: 1801 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1860

Query: 351  KPSSWLRTLAGSSN------KSLGCVHP---RQRLSAFRPWSPAVSASEKELSPHLPALI 401
              +  LR LA          +     H     +RL+  R       AS+ EL      L+
Sbjct: 1861 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR------KASDSELERQ-KGLV 1913

Query: 402  RDSFYSYKSFETAV-APNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQP-----RKR 455
             D+    +  E  + A   +    A  K           S A + L +  Q      R+R
Sbjct: 1914 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1973

Query: 456  KLTVDTPG----APETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSS-PSFTSSSSA 510
            +L  +       A E +    A EE+   + +  +E  E   + +             SA
Sbjct: 1974 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2033

Query: 511  KDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDT----KEAKEKFLHEV 566
            + L      A      +  A A A    E EL+   Q  +  LD      EA  +   E 
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093

Query: 567  VKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEK- 625
             + RV+ E +   A Q++R + +E E L    K+   E  +A+   +   E+LR E E+ 
Sbjct: 2094 EEARVQAERE---AAQSRRQV-EEAERL----KQSAEEQAQARAQAQAAAEKLRKEAEQE 2145

Query: 626  --KMKEANESRLRLKR--ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
              +  +A ++ LR K+  + E  +  +  +   +  R +A+   ++  L+++L+  +  +
Sbjct: 2146 AARRAQAEQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLEETDHQK 2202

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLW 710
              L  +L R +       +   +++E+L+
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELF 2231



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 57/229 (24%), Positives = 101/229 (44%), Gaps = 30/229 (13%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTK---EAKEKFLHEVVKMRVKQE----EKLSA 579
            +AAA       LEAEL  +R  +E  L +K   E + +   E  K R++ E     +L+ 
Sbjct: 1742 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801

Query: 580  ALQAKRSLHQELEFLR-VAKKEKLREATEAKRNLRKEIERL-----------------RA 621
                 R+L +E +  R +A+++  R+  EA+R L +++  +                  A
Sbjct: 1802 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1861

Query: 622  ENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
            ENE+  + A +   + +R  EQA Q +  D      +LR    +++E  +  ++     R
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQR 1920

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAG---SEGAAELE 727
             Q+  ++L  + + E       EL+ +L  R R  A     S+  AELE
Sbjct: 1921 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELE 1968



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 62/229 (27%), Positives = 93/229 (40%), Gaps = 60/229 (26%)

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVV-KMRVKQEE--KLSAALQ--------AK 584
            S L+A +E   +AL   L  K+  ++FL E   KM+   EE  +LS A Q        A+
Sbjct: 2241 SKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIE--------------RLRAENEKKMKEA 630
              L Q+        KEK++   EA R L+ E E              RL+ + E+  ++ 
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357

Query: 631  NESRLRLKRELEQARQARVCDKGCEAGRLRAK-----------------YSAQIEDLQVK 673
             E     +R LE  RQ R  +   EA RL+ +                 +  Q E++  K
Sbjct: 2358 AEETQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2416

Query: 674  L--------------QHAEADREQLRADLLREREAREHLEKVVKELQEQ 708
            L              Q  E  R+Q   D  R REA   LE+  ++LQ++
Sbjct: 2417 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2465


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 65/267 (24%), Positives = 119/267 (44%), Gaps = 41/267 (15%)

Query: 473  APEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPA 532
            A E ++ +E E  +E + +   + +   + +      AK+L     R     V    A  
Sbjct: 1324 AEERERLAEVEAALEKQRQLAEAHAQAKAQA---EREAKELQQ---RMQEEVVRREEAAV 1377

Query: 533  DAPS---GLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEK-----LSAALQAK 584
            DA      ++ EL+ LRQ+ E  +  K A++    E  ++R+++E +     L A  + +
Sbjct: 1378 DAQQQKRSIQEELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1436

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRA----ENEKKMKEANESRLRLKRE 640
                 EL+ LR     +  EA   KR  ++E ERLR     E+++K +   E   R+K E
Sbjct: 1437 GGAEGELQALRA----RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1492

Query: 641  LEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEK 700
             E AR+ +   +  E               +++LQ  EA+R   +A++ R R+ +  LE 
Sbjct: 1493 AEAAREKQRALQALE---------------ELRLQAEEAERRLRQAEVERARQVQVALET 1537

Query: 701  VVKELQEQLWPRARPEAAGSEGAAELE 727
              +  + +L  +    A+ +E  A+LE
Sbjct: 1538 AQRSAEAELQSK---RASFAEKTAQLE 1561



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 58/215 (26%), Positives = 100/215 (46%), Gaps = 39/215 (18%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            E ELE  RQ  EG    + A E+   E++++R + E+      Q ++ L +EL  L+   
Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQ---ELIRLRAETEQ----GEQQRQLLEEELARLQ--- 1708

Query: 599  KEKLREATEAKRNLRKEIERLRAENE----KKMKEANESRLRLKRELE--QARQARVCDK 652
              +   AT+ ++ L  E+ ++RAE E     K +   ESR   ++  +  +A   R  + 
Sbjct: 1709 -REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1767

Query: 653  GCEAGRLR-----AKYSAQIEDLQVKLQHAEADR---EQLRA------------DLLRER 692
              EA RLR     AK   Q+ +     Q AEA+R   E+L A              L+E+
Sbjct: 1768 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1827

Query: 693  EAREHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            EA    E++ +  +++ + R R E   ++  A++E
Sbjct: 1828 EAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE 1860



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 70/272 (25%), Positives = 120/272 (44%), Gaps = 24/272 (8%)

Query: 466  ETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAV 525
            E L      E  +  +AEVE+ SR +  +  +     +  +    +       R L  A 
Sbjct: 1465 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1524

Query: 526  PDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKM-RVKQEEKLSAAL--- 581
             + A        ++  LE  +++ E  L +K A   F  +  ++ R  QEE ++ A    
Sbjct: 1525 VERARQ------VQVALETAQRSAEAELQSKRAS--FAEKTAQLERSLQEEHVAVAQLRE 1576

Query: 582  QAKRSLHQELEFLRV---AKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLK 638
            +A+R   Q+ E  R    A++E  R   +A   LR    RL+AE   + K   ++    +
Sbjct: 1577 EAERRAQQQAEAERAREEAERELERWQLKANEALRL---RLQAEEVAQQKSLAQAEAEKQ 1633

Query: 639  RELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRA---DLLREREAR 695
            +E E  R+AR   K  E   +R +  A+ ++L+ + Q AE   +Q  A   +L+R R   
Sbjct: 1634 KE-EAEREARRRGK-AEEQAVRQRELAE-QELEKQRQLAEGTAQQRLAAEQELIRLRAET 1690

Query: 696  EHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            E  E+  + L+E+L    R  AA ++   ELE
Sbjct: 1691 EQGEQQRQLLEEELARLQREAAAATQKRQELE 1722



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 37/158 (23%), Positives = 77/158 (48%), Gaps = 21/158 (13%)

Query: 568  KMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKM 627
            + R ++ E+L+    A     Q  E    AK +  REA E ++ +++E+ R     E+  
Sbjct: 1321 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR----REEAA 1376

Query: 628  KEANESRLRLKRELEQARQARVCD--------KGCEAGRLRAKYSAQIEDLQVKLQH--- 676
             +A + +  ++ EL+Q RQ+   +        +  E  RLR +   ++  LQ++      
Sbjct: 1377 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1436

Query: 677  --AEADREQLRADL----LREREAREHLEKVVKELQEQ 708
              AE + + LRA       ++R+A+E  E++ +++Q++
Sbjct: 1437 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1474



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 26/190 (13%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            EAE    +QA     + + A+E+   E+ + ++K  E L   LQA+    Q+      A+
Sbjct: 1577 EAERRAQQQA-----EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1631

Query: 599  KEKLREATEAKRNLRKEIERLR--------AENEKKMKE--------ANESRLRLKRELE 642
            K+K     EA+R  + E + +R         E ++++ E        A +  +RL+ E E
Sbjct: 1632 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1691

Query: 643  QARQARVCDKGCEAGRLRAKYSA---QIEDLQVKLQHAEADREQLRADLLR-EREAREHL 698
            Q  Q R   +  E  RL+ + +A   + ++L+ +L    A+ E L A   R E E+R   
Sbjct: 1692 QGEQQRQLLEE-ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1750

Query: 699  EKVVKELQEQ 708
            EK  + L+ +
Sbjct: 1751 EKSKQRLEAE 1760



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/182 (28%), Positives = 83/182 (45%), Gaps = 21/182 (11%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRS 586
            DA    +A + LE E E L+Q         EAK   L       V+QE+ L      ++S
Sbjct: 2412 DAERLREAIAELEREKEKLQQ---------EAKLLQLKSEEMQTVQQEQLLQETQALQQS 2462

Query: 587  LHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQ 646
               E + L   ++E+  E  +AK      +E+L  +   K ++  E + R ++++EQ RQ
Sbjct: 2463 FLSEKDSL--LQRERFIEQEKAK------LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2514

Query: 647  ARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQ 706
              V     EA R + +    +   Q +LQ  E  R Q + +LL E   R  L + ++ L+
Sbjct: 2515 RLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQ-QEELLAEENQR--LREQLQLLE 2570

Query: 707  EQ 708
            EQ
Sbjct: 2571 EQ 2572



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 94/449 (20%), Positives = 171/449 (38%), Gaps = 51/449 (11%)

Query: 295  EEQARLGRCLDDVKEKFDYGN----KYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKD 350
            EE ARL    ++ K +         + +    RV +E  A+I   T   +    A  EK+
Sbjct: 1769 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1828

Query: 351  KPSSWLRTLAGSSN------KSLGCVHP---RQRLSAFRPWSPAVSASEKELSPHLPALI 401
              +  LR LA          +     H     +RL+  R       AS+ EL      L+
Sbjct: 1829 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR------KASDSELERQ-KGLV 1881

Query: 402  RDSFYSYKSFETAV-APNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQP-----RKR 455
             D+    +  E  + A   +    A  K           S A + L +  Q      R+R
Sbjct: 1882 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1941

Query: 456  KLTVDTPG----APETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSS-PSFTSSSSA 510
            +L  +       A E +    A EE+   + +  +E  E   + +             SA
Sbjct: 1942 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2001

Query: 511  KDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDT----KEAKEKFLHEV 566
            + L      A      +  A A A    E EL+   Q  +  LD      EA  +   E 
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2061

Query: 567  VKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEK- 625
             + RV+ E +   A Q++R + +E E L    K+   E  +A+   +   E+LR E E+ 
Sbjct: 2062 EEARVQAERE---AAQSRRQV-EEAERL----KQSAEEQAQARAQAQAAAEKLRKEAEQE 2113

Query: 626  --KMKEANESRLRLKR--ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
              +  +A ++ LR K+  + E  +  +  +   +  R +A+   ++  L+++L+  +  +
Sbjct: 2114 AARRAQAEQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLEETDHQK 2170

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLW 710
              L  +L R +       +   +++E+L+
Sbjct: 2171 NLLDEELQRLKAEATEAARQRSQVEEELF 2199



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 57/229 (24%), Positives = 101/229 (44%), Gaps = 30/229 (13%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTK---EAKEKFLHEVVKMRVKQE----EKLSA 579
            +AAA       LEAEL  +R  +E  L +K   E + +   E  K R++ E     +L+ 
Sbjct: 1710 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769

Query: 580  ALQAKRSLHQELEFLR-VAKKEKLREATEAKRNLRKEIERL-----------------RA 621
                 R+L +E +  R +A+++  R+  EA+R L +++  +                  A
Sbjct: 1770 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1829

Query: 622  ENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
            ENE+  + A +   + +R  EQA Q +  D      +LR    +++E  +  ++     R
Sbjct: 1830 ENERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQR 1888

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAG---SEGAAELE 727
             Q+  ++L  + + E       EL+ +L  R R  A     S+  AELE
Sbjct: 1889 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELE 1936



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 62/229 (27%), Positives = 93/229 (40%), Gaps = 60/229 (26%)

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVV-KMRVKQEE--KLSAALQ--------AK 584
            S L+A +E   +AL   L  K+  ++FL E   KM+   EE  +LS A Q        A+
Sbjct: 2209 SKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2266

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIE--------------RLRAENEKKMKEA 630
              L Q+        KEK++   EA R L+ E E              RL+ + E+  ++ 
Sbjct: 2267 EDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325

Query: 631  NESRLRLKRELEQARQARVCDKGCEAGRLRAK-----------------YSAQIEDLQVK 673
             E     +R LE  RQ R  +   EA RL+ +                 +  Q E++  K
Sbjct: 2326 AEETQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2384

Query: 674  L--------------QHAEADREQLRADLLREREAREHLEKVVKELQEQ 708
            L              Q  E  R+Q   D  R REA   LE+  ++LQ++
Sbjct: 2385 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2433


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 65/267 (24%), Positives = 119/267 (44%), Gaps = 41/267 (15%)

Query: 473  APEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPA 532
            A E ++ +E E  +E + +   + +   + +      AK+L     R     V    A  
Sbjct: 1493 AEERERLAEVEAALEKQRQLAEAHAQAKAQA---EREAKELQQ---RMQEEVVRREEAAV 1546

Query: 533  DAPS---GLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEK-----LSAALQAK 584
            DA      ++ EL+ LRQ+ E  +  K A++    E  ++R+++E +     L A  + +
Sbjct: 1547 DAQQQKRSIQEELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1605

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRA----ENEKKMKEANESRLRLKRE 640
                 EL+ LR     +  EA   KR  ++E ERLR     E+++K +   E   R+K E
Sbjct: 1606 GGAEGELQALRA----RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1661

Query: 641  LEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEK 700
             E AR+ +   +  E               +++LQ  EA+R   +A++ R R+ +  LE 
Sbjct: 1662 AEAAREKQRALQALE---------------ELRLQAEEAERRLRQAEVERARQVQVALET 1706

Query: 701  VVKELQEQLWPRARPEAAGSEGAAELE 727
              +  + +L  +    A+ +E  A+LE
Sbjct: 1707 AQRSAEAELQSK---RASFAEKTAQLE 1730



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 58/215 (26%), Positives = 100/215 (46%), Gaps = 39/215 (18%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            E ELE  RQ  EG    + A E+   E++++R + E+      Q ++ L +EL  L+   
Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQ---ELIRLRAETEQ----GEQQRQLLEEELARLQ--- 1877

Query: 599  KEKLREATEAKRNLRKEIERLRAENE----KKMKEANESRLRLKRELE--QARQARVCDK 652
              +   AT+ ++ L  E+ ++RAE E     K +   ESR   ++  +  +A   R  + 
Sbjct: 1878 -REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1936

Query: 653  GCEAGRLR-----AKYSAQIEDLQVKLQHAEADR---EQLRA------------DLLRER 692
              EA RLR     AK   Q+ +     Q AEA+R   E+L A              L+E+
Sbjct: 1937 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1996

Query: 693  EAREHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            EA    E++ +  +++ + R R E   ++  A++E
Sbjct: 1997 EAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE 2029



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 70/272 (25%), Positives = 120/272 (44%), Gaps = 24/272 (8%)

Query: 466  ETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAV 525
            E L      E  +  +AEVE+ SR +  +  +     +  +    +       R L  A 
Sbjct: 1634 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1693

Query: 526  PDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKM-RVKQEEKLSAAL--- 581
             + A        ++  LE  +++ E  L +K A   F  +  ++ R  QEE ++ A    
Sbjct: 1694 VERARQ------VQVALETAQRSAEAELQSKRAS--FAEKTAQLERSLQEEHVAVAQLRE 1745

Query: 582  QAKRSLHQELEFLRV---AKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLK 638
            +A+R   Q+ E  R    A++E  R   +A   LR    RL+AE   + K   ++    +
Sbjct: 1746 EAERRAQQQAEAERAREEAERELERWQLKANEALRL---RLQAEEVAQQKSLAQAEAEKQ 1802

Query: 639  RELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRA---DLLREREAR 695
            +E E  R+AR   K  E   +R +  A+ ++L+ + Q AE   +Q  A   +L+R R   
Sbjct: 1803 KE-EAEREARRRGK-AEEQAVRQRELAE-QELEKQRQLAEGTAQQRLAAEQELIRLRAET 1859

Query: 696  EHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            E  E+  + L+E+L    R  AA ++   ELE
Sbjct: 1860 EQGEQQRQLLEEELARLQREAAAATQKRQELE 1891



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 37/158 (23%), Positives = 77/158 (48%), Gaps = 21/158 (13%)

Query: 568  KMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKM 627
            + R ++ E+L+    A     Q  E    AK +  REA E ++ +++E+ R     E+  
Sbjct: 1490 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR----REEAA 1545

Query: 628  KEANESRLRLKRELEQARQARVCD--------KGCEAGRLRAKYSAQIEDLQVKLQH--- 676
             +A + +  ++ EL+Q RQ+   +        +  E  RLR +   ++  LQ++      
Sbjct: 1546 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1605

Query: 677  --AEADREQLRADL----LREREAREHLEKVVKELQEQ 708
              AE + + LRA       ++R+A+E  E++ +++Q++
Sbjct: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 26/190 (13%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            EAE    +QA     + + A+E+   E+ + ++K  E L   LQA+    Q+      A+
Sbjct: 1746 EAERRAQQQA-----EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800

Query: 599  KEKLREATEAKRNLRKEIERLR--------AENEKKMKE--------ANESRLRLKRELE 642
            K+K     EA+R  + E + +R         E ++++ E        A +  +RL+ E E
Sbjct: 1801 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860

Query: 643  QARQARVCDKGCEAGRLRAKYSA---QIEDLQVKLQHAEADREQLRADLLR-EREAREHL 698
            Q  Q R   +  E  RL+ + +A   + ++L+ +L    A+ E L A   R E E+R   
Sbjct: 1861 QGEQQRQLLEE-ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1919

Query: 699  EKVVKELQEQ 708
            EK  + L+ +
Sbjct: 1920 EKSKQRLEAE 1929



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/182 (28%), Positives = 83/182 (45%), Gaps = 21/182 (11%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRS 586
            DA    +A + LE E E L+Q         EAK   L       V+QE+ L      ++S
Sbjct: 2581 DAERLREAIAELEREKEKLQQ---------EAKLLQLKSEEMQTVQQEQLLQETQALQQS 2631

Query: 587  LHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQ 646
               E + L   ++E+  E  +AK      +E+L  +   K ++  E + R ++++EQ RQ
Sbjct: 2632 FLSEKDSL--LQRERFIEQEKAK------LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2683

Query: 647  ARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQ 706
              V     EA R + +    +   Q +LQ  E  R Q + +LL E   R  L + ++ L+
Sbjct: 2684 RLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQ-QEELLAEENQR--LREQLQLLE 2739

Query: 707  EQ 708
            EQ
Sbjct: 2740 EQ 2741



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 94/449 (20%), Positives = 171/449 (38%), Gaps = 51/449 (11%)

Query: 295  EEQARLGRCLDDVKEKFDYGN----KYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKD 350
            EE ARL    ++ K +         + +    RV +E  A+I   T   +    A  EK+
Sbjct: 1938 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1997

Query: 351  KPSSWLRTLAGSSN------KSLGCVHP---RQRLSAFRPWSPAVSASEKELSPHLPALI 401
              +  LR LA          +     H     +RL+  R       AS+ EL      L+
Sbjct: 1998 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR------KASDSELERQ-KGLV 2050

Query: 402  RDSFYSYKSFETAV-APNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQP-----RKR 455
             D+    +  E  + A   +    A  K           S A + L +  Q      R+R
Sbjct: 2051 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2110

Query: 456  KLTVDTPG----APETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSS-PSFTSSSSA 510
            +L  +       A E +    A EE+   + +  +E  E   + +             SA
Sbjct: 2111 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2170

Query: 511  KDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDT----KEAKEKFLHEV 566
            + L      A      +  A A A    E EL+   Q  +  LD      EA  +   E 
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2230

Query: 567  VKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEK- 625
             + RV+ E +   A Q++R + +E E L    K+   E  +A+   +   E+LR E E+ 
Sbjct: 2231 EEARVQAERE---AAQSRRQV-EEAERL----KQSAEEQAQARAQAQAAAEKLRKEAEQE 2282

Query: 626  --KMKEANESRLRLKR--ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
              +  +A ++ LR K+  + E  +  +  +   +  R +A+   ++  L+++L+  +  +
Sbjct: 2283 AARRAQAEQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLEETDHQK 2339

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLW 710
              L  +L R +       +   +++E+L+
Sbjct: 2340 NLLDEELQRLKAEATEAARQRSQVEEELF 2368



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 57/229 (24%), Positives = 101/229 (44%), Gaps = 30/229 (13%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTK---EAKEKFLHEVVKMRVKQE----EKLSA 579
            +AAA       LEAEL  +R  +E  L +K   E + +   E  K R++ E     +L+ 
Sbjct: 1879 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938

Query: 580  ALQAKRSLHQELEFLR-VAKKEKLREATEAKRNLRKEIERL-----------------RA 621
                 R+L +E +  R +A+++  R+  EA+R L +++  +                  A
Sbjct: 1939 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998

Query: 622  ENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
            ENE+  + A +   + +R  EQA Q +  D      +LR    +++E  +  ++     R
Sbjct: 1999 ENERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAG---SEGAAELE 727
             Q+  ++L  + + E       EL+ +L  R R  A     S+  AELE
Sbjct: 2058 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELE 2105



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 62/229 (27%), Positives = 93/229 (40%), Gaps = 60/229 (26%)

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVV-KMRVKQEE--KLSAALQ--------AK 584
            S L+A +E   +AL   L  K+  ++FL E   KM+   EE  +LS A Q        A+
Sbjct: 2378 SKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2435

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIE--------------RLRAENEKKMKEA 630
              L Q+        KEK++   EA R L+ E E              RL+ + E+  ++ 
Sbjct: 2436 EDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494

Query: 631  NESRLRLKRELEQARQARVCDKGCEAGRLRAK-----------------YSAQIEDLQVK 673
             E     +R LE  RQ R  +   EA RL+ +                 +  Q E++  K
Sbjct: 2495 AEETQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2553

Query: 674  L--------------QHAEADREQLRADLLREREAREHLEKVVKELQEQ 708
            L              Q  E  R+Q   D  R REA   LE+  ++LQ++
Sbjct: 2554 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2602


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 65/267 (24%), Positives = 119/267 (44%), Gaps = 41/267 (15%)

Query: 473  APEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPA 532
            A E ++ +E E  +E + +   + +   + +      AK+L     R     V    A  
Sbjct: 1334 AEERERLAEVEAALEKQRQLAEAHAQAKAQA---EREAKELQQ---RMQEEVVRREEAAV 1387

Query: 533  DAPS---GLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEK-----LSAALQAK 584
            DA      ++ EL+ LRQ+ E  +  K A++    E  ++R+++E +     L A  + +
Sbjct: 1388 DAQQQKRSIQEELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1446

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRA----ENEKKMKEANESRLRLKRE 640
                 EL+ LR     +  EA   KR  ++E ERLR     E+++K +   E   R+K E
Sbjct: 1447 GGAEGELQALRA----RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1502

Query: 641  LEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEK 700
             E AR+ +   +  E               +++LQ  EA+R   +A++ R R+ +  LE 
Sbjct: 1503 AEAAREKQRALQALE---------------ELRLQAEEAERRLRQAEVERARQVQVALET 1547

Query: 701  VVKELQEQLWPRARPEAAGSEGAAELE 727
              +  + +L  +    A+ +E  A+LE
Sbjct: 1548 AQRSAEAELQSK---RASFAEKTAQLE 1571



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 58/215 (26%), Positives = 100/215 (46%), Gaps = 39/215 (18%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            E ELE  RQ  EG    + A E+   E++++R + E+      Q ++ L +EL  L+   
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQ---ELIRLRAETEQ----GEQQRQLLEEELARLQ--- 1718

Query: 599  KEKLREATEAKRNLRKEIERLRAENE----KKMKEANESRLRLKRELE--QARQARVCDK 652
              +   AT+ ++ L  E+ ++RAE E     K +   ESR   ++  +  +A   R  + 
Sbjct: 1719 -REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1777

Query: 653  GCEAGRLR-----AKYSAQIEDLQVKLQHAEADR---EQLRA------------DLLRER 692
              EA RLR     AK   Q+ +     Q AEA+R   E+L A              L+E+
Sbjct: 1778 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1837

Query: 693  EAREHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            EA    E++ +  +++ + R R E   ++  A++E
Sbjct: 1838 EAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE 1870



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 70/272 (25%), Positives = 120/272 (44%), Gaps = 24/272 (8%)

Query: 466  ETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAV 525
            E L      E  +  +AEVE+ SR +  +  +     +  +    +       R L  A 
Sbjct: 1475 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1534

Query: 526  PDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKM-RVKQEEKLSAAL--- 581
             + A        ++  LE  +++ E  L +K A   F  +  ++ R  QEE ++ A    
Sbjct: 1535 VERARQ------VQVALETAQRSAEAELQSKRAS--FAEKTAQLERSLQEEHVAVAQLRE 1586

Query: 582  QAKRSLHQELEFLRV---AKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLK 638
            +A+R   Q+ E  R    A++E  R   +A   LR    RL+AE   + K   ++    +
Sbjct: 1587 EAERRAQQQAEAERAREEAERELERWQLKANEALRL---RLQAEEVAQQKSLAQAEAEKQ 1643

Query: 639  RELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRA---DLLREREAR 695
            +E E  R+AR   K  E   +R +  A+ ++L+ + Q AE   +Q  A   +L+R R   
Sbjct: 1644 KE-EAEREARRRGK-AEEQAVRQRELAE-QELEKQRQLAEGTAQQRLAAEQELIRLRAET 1700

Query: 696  EHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            E  E+  + L+E+L    R  AA ++   ELE
Sbjct: 1701 EQGEQQRQLLEEELARLQREAAAATQKRQELE 1732



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 37/158 (23%), Positives = 77/158 (48%), Gaps = 21/158 (13%)

Query: 568  KMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKM 627
            + R ++ E+L+    A     Q  E    AK +  REA E ++ +++E+ R     E+  
Sbjct: 1331 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR----REEAA 1386

Query: 628  KEANESRLRLKRELEQARQARVCD--------KGCEAGRLRAKYSAQIEDLQVKLQH--- 676
             +A + +  ++ EL+Q RQ+   +        +  E  RLR +   ++  LQ++      
Sbjct: 1387 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1446

Query: 677  --AEADREQLRADL----LREREAREHLEKVVKELQEQ 708
              AE + + LRA       ++R+A+E  E++ +++Q++
Sbjct: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 26/190 (13%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            EAE    +QA     + + A+E+   E+ + ++K  E L   LQA+    Q+      A+
Sbjct: 1587 EAERRAQQQA-----EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1641

Query: 599  KEKLREATEAKRNLRKEIERLR--------AENEKKMKE--------ANESRLRLKRELE 642
            K+K     EA+R  + E + +R         E ++++ E        A +  +RL+ E E
Sbjct: 1642 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1701

Query: 643  QARQARVCDKGCEAGRLRAKYSA---QIEDLQVKLQHAEADREQLRADLLR-EREAREHL 698
            Q  Q R   +  E  RL+ + +A   + ++L+ +L    A+ E L A   R E E+R   
Sbjct: 1702 QGEQQRQLLEE-ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1760

Query: 699  EKVVKELQEQ 708
            EK  + L+ +
Sbjct: 1761 EKSKQRLEAE 1770



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/182 (28%), Positives = 83/182 (45%), Gaps = 21/182 (11%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRS 586
            DA    +A + LE E E L+Q         EAK   L       V+QE+ L      ++S
Sbjct: 2422 DAERLREAIAELEREKEKLQQ---------EAKLLQLKSEEMQTVQQEQLLQETQALQQS 2472

Query: 587  LHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQ 646
               E + L   ++E+  E  +AK      +E+L  +   K ++  E + R ++++EQ RQ
Sbjct: 2473 FLSEKDSL--LQRERFIEQEKAK------LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2524

Query: 647  ARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQ 706
              V     EA R + +    +   Q +LQ  E  R Q + +LL E   R  L + ++ L+
Sbjct: 2525 RLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQ-QEELLAEENQR--LREQLQLLE 2580

Query: 707  EQ 708
            EQ
Sbjct: 2581 EQ 2582



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 94/449 (20%), Positives = 171/449 (38%), Gaps = 51/449 (11%)

Query: 295  EEQARLGRCLDDVKEKFDYGN----KYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKD 350
            EE ARL    ++ K +         + +    RV +E  A+I   T   +    A  EK+
Sbjct: 1779 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1838

Query: 351  KPSSWLRTLAGSSN------KSLGCVHP---RQRLSAFRPWSPAVSASEKELSPHLPALI 401
              +  LR LA          +     H     +RL+  R       AS+ EL      L+
Sbjct: 1839 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR------KASDSELERQ-KGLV 1891

Query: 402  RDSFYSYKSFETAV-APNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQP-----RKR 455
             D+    +  E  + A   +    A  K           S A + L +  Q      R+R
Sbjct: 1892 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1951

Query: 456  KLTVDTPG----APETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSS-PSFTSSSSA 510
            +L  +       A E +    A EE+   + +  +E  E   + +             SA
Sbjct: 1952 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2011

Query: 511  KDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDT----KEAKEKFLHEV 566
            + L      A      +  A A A    E EL+   Q  +  LD      EA  +   E 
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2071

Query: 567  VKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEK- 625
             + RV+ E +   A Q++R + +E E L    K+   E  +A+   +   E+LR E E+ 
Sbjct: 2072 EEARVQAERE---AAQSRRQV-EEAERL----KQSAEEQAQARAQAQAAAEKLRKEAEQE 2123

Query: 626  --KMKEANESRLRLKR--ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
              +  +A ++ LR K+  + E  +  +  +   +  R +A+   ++  L+++L+  +  +
Sbjct: 2124 AARRAQAEQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLEETDHQK 2180

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLW 710
              L  +L R +       +   +++E+L+
Sbjct: 2181 NLLDEELQRLKAEATEAARQRSQVEEELF 2209



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 57/229 (24%), Positives = 101/229 (44%), Gaps = 30/229 (13%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTK---EAKEKFLHEVVKMRVKQE----EKLSA 579
            +AAA       LEAEL  +R  +E  L +K   E + +   E  K R++ E     +L+ 
Sbjct: 1720 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1779

Query: 580  ALQAKRSLHQELEFLR-VAKKEKLREATEAKRNLRKEIERL-----------------RA 621
                 R+L +E +  R +A+++  R+  EA+R L +++  +                  A
Sbjct: 1780 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839

Query: 622  ENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
            ENE+  + A +   + +R  EQA Q +  D      +LR    +++E  +  ++     R
Sbjct: 1840 ENERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAG---SEGAAELE 727
             Q+  ++L  + + E       EL+ +L  R R  A     S+  AELE
Sbjct: 1899 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELE 1946



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 62/229 (27%), Positives = 93/229 (40%), Gaps = 60/229 (26%)

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVV-KMRVKQEE--KLSAALQ--------AK 584
            S L+A +E   +AL   L  K+  ++FL E   KM+   EE  +LS A Q        A+
Sbjct: 2219 SKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2276

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIE--------------RLRAENEKKMKEA 630
              L Q+        KEK++   EA R L+ E E              RL+ + E+  ++ 
Sbjct: 2277 EDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335

Query: 631  NESRLRLKRELEQARQARVCDKGCEAGRLRAK-----------------YSAQIEDLQVK 673
             E     +R LE  RQ R  +   EA RL+ +                 +  Q E++  K
Sbjct: 2336 AEETQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2394

Query: 674  L--------------QHAEADREQLRADLLREREAREHLEKVVKELQEQ 708
            L              Q  E  R+Q   D  R REA   LE+  ++LQ++
Sbjct: 2395 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2443


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 65/267 (24%), Positives = 119/267 (44%), Gaps = 41/267 (15%)

Query: 473  APEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPA 532
            A E ++ +E E  +E + +   + +   + +      AK+L     R     V    A  
Sbjct: 1342 AEERERLAEVEAALEKQRQLAEAHAQAKAQA---EREAKELQQ---RMQEEVVRREEAAV 1395

Query: 533  DAPS---GLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEK-----LSAALQAK 584
            DA      ++ EL+ LRQ+ E  +  K A++    E  ++R+++E +     L A  + +
Sbjct: 1396 DAQQQKRSIQEELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1454

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRA----ENEKKMKEANESRLRLKRE 640
                 EL+ LR     +  EA   KR  ++E ERLR     E+++K +   E   R+K E
Sbjct: 1455 GGAEGELQALRA----RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1510

Query: 641  LEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEK 700
             E AR+ +   +  E               +++LQ  EA+R   +A++ R R+ +  LE 
Sbjct: 1511 AEAAREKQRALQALE---------------ELRLQAEEAERRLRQAEVERARQVQVALET 1555

Query: 701  VVKELQEQLWPRARPEAAGSEGAAELE 727
              +  + +L  +    A+ +E  A+LE
Sbjct: 1556 AQRSAEAELQSK---RASFAEKTAQLE 1579



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 58/215 (26%), Positives = 100/215 (46%), Gaps = 39/215 (18%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            E ELE  RQ  EG    + A E+   E++++R + E+      Q ++ L +EL  L+   
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQ---ELIRLRAETEQ----GEQQRQLLEEELARLQ--- 1726

Query: 599  KEKLREATEAKRNLRKEIERLRAENE----KKMKEANESRLRLKRELE--QARQARVCDK 652
              +   AT+ ++ L  E+ ++RAE E     K +   ESR   ++  +  +A   R  + 
Sbjct: 1727 -REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1785

Query: 653  GCEAGRLR-----AKYSAQIEDLQVKLQHAEADR---EQLRA------------DLLRER 692
              EA RLR     AK   Q+ +     Q AEA+R   E+L A              L+E+
Sbjct: 1786 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1845

Query: 693  EAREHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            EA    E++ +  +++ + R R E   ++  A++E
Sbjct: 1846 EAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE 1878



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 70/272 (25%), Positives = 120/272 (44%), Gaps = 24/272 (8%)

Query: 466  ETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAV 525
            E L      E  +  +AEVE+ SR +  +  +     +  +    +       R L  A 
Sbjct: 1483 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1542

Query: 526  PDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKM-RVKQEEKLSAAL--- 581
             + A        ++  LE  +++ E  L +K A   F  +  ++ R  QEE ++ A    
Sbjct: 1543 VERARQ------VQVALETAQRSAEAELQSKRAS--FAEKTAQLERSLQEEHVAVAQLRE 1594

Query: 582  QAKRSLHQELEFLRV---AKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLK 638
            +A+R   Q+ E  R    A++E  R   +A   LR    RL+AE   + K   ++    +
Sbjct: 1595 EAERRAQQQAEAERAREEAERELERWQLKANEALRL---RLQAEEVAQQKSLAQAEAEKQ 1651

Query: 639  RELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRA---DLLREREAR 695
            +E E  R+AR   K  E   +R +  A+ ++L+ + Q AE   +Q  A   +L+R R   
Sbjct: 1652 KE-EAEREARRRGK-AEEQAVRQRELAE-QELEKQRQLAEGTAQQRLAAEQELIRLRAET 1708

Query: 696  EHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            E  E+  + L+E+L    R  AA ++   ELE
Sbjct: 1709 EQGEQQRQLLEEELARLQREAAAATQKRQELE 1740



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 37/158 (23%), Positives = 77/158 (48%), Gaps = 21/158 (13%)

Query: 568  KMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKM 627
            + R ++ E+L+    A     Q  E    AK +  REA E ++ +++E+ R     E+  
Sbjct: 1339 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR----REEAA 1394

Query: 628  KEANESRLRLKRELEQARQARVCD--------KGCEAGRLRAKYSAQIEDLQVKLQH--- 676
             +A + +  ++ EL+Q RQ+   +        +  E  RLR +   ++  LQ++      
Sbjct: 1395 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1454

Query: 677  --AEADREQLRADL----LREREAREHLEKVVKELQEQ 708
              AE + + LRA       ++R+A+E  E++ +++Q++
Sbjct: 1455 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1492



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 26/190 (13%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            EAE    +QA     + + A+E+   E+ + ++K  E L   LQA+    Q+      A+
Sbjct: 1595 EAERRAQQQA-----EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1649

Query: 599  KEKLREATEAKRNLRKEIERLR--------AENEKKMKE--------ANESRLRLKRELE 642
            K+K     EA+R  + E + +R         E ++++ E        A +  +RL+ E E
Sbjct: 1650 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1709

Query: 643  QARQARVCDKGCEAGRLRAKYSA---QIEDLQVKLQHAEADREQLRADLLR-EREAREHL 698
            Q  Q R   +  E  RL+ + +A   + ++L+ +L    A+ E L A   R E E+R   
Sbjct: 1710 QGEQQRQLLEE-ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1768

Query: 699  EKVVKELQEQ 708
            EK  + L+ +
Sbjct: 1769 EKSKQRLEAE 1778



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/182 (28%), Positives = 83/182 (45%), Gaps = 21/182 (11%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRS 586
            DA    +A + LE E E L+Q         EAK   L       V+QE+ L      ++S
Sbjct: 2430 DAERLREAIAELEREKEKLQQ---------EAKLLQLKSEEMQTVQQEQLLQETQALQQS 2480

Query: 587  LHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQ 646
               E + L   ++E+  E  +AK      +E+L  +   K ++  E + R ++++EQ RQ
Sbjct: 2481 FLSEKDSL--LQRERFIEQEKAK------LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2532

Query: 647  ARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQ 706
              V     EA R + +    +   Q +LQ  E  R Q + +LL E   R  L + ++ L+
Sbjct: 2533 RLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQ-QEELLAEENQR--LREQLQLLE 2588

Query: 707  EQ 708
            EQ
Sbjct: 2589 EQ 2590



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 94/449 (20%), Positives = 171/449 (38%), Gaps = 51/449 (11%)

Query: 295  EEQARLGRCLDDVKEKFDYGN----KYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKD 350
            EE ARL    ++ K +         + +    RV +E  A+I   T   +    A  EK+
Sbjct: 1787 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1846

Query: 351  KPSSWLRTLAGSSN------KSLGCVHP---RQRLSAFRPWSPAVSASEKELSPHLPALI 401
              +  LR LA          +     H     +RL+  R       AS+ EL      L+
Sbjct: 1847 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR------KASDSELERQ-KGLV 1899

Query: 402  RDSFYSYKSFETAV-APNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQP-----RKR 455
             D+    +  E  + A   +    A  K           S A + L +  Q      R+R
Sbjct: 1900 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 1959

Query: 456  KLTVDTPG----APETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSS-PSFTSSSSA 510
            +L  +       A E +    A EE+   + +  +E  E   + +             SA
Sbjct: 1960 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2019

Query: 511  KDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDT----KEAKEKFLHEV 566
            + L      A      +  A A A    E EL+   Q  +  LD      EA  +   E 
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2079

Query: 567  VKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEK- 625
             + RV+ E +   A Q++R + +E E L    K+   E  +A+   +   E+LR E E+ 
Sbjct: 2080 EEARVQAERE---AAQSRRQV-EEAERL----KQSAEEQAQARAQAQAAAEKLRKEAEQE 2131

Query: 626  --KMKEANESRLRLKR--ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
              +  +A ++ LR K+  + E  +  +  +   +  R +A+   ++  L+++L+  +  +
Sbjct: 2132 AARRAQAEQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLEETDHQK 2188

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLW 710
              L  +L R +       +   +++E+L+
Sbjct: 2189 NLLDEELQRLKAEATEAARQRSQVEEELF 2217



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 57/229 (24%), Positives = 101/229 (44%), Gaps = 30/229 (13%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTK---EAKEKFLHEVVKMRVKQE----EKLSA 579
            +AAA       LEAEL  +R  +E  L +K   E + +   E  K R++ E     +L+ 
Sbjct: 1728 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1787

Query: 580  ALQAKRSLHQELEFLR-VAKKEKLREATEAKRNLRKEIERL-----------------RA 621
                 R+L +E +  R +A+++  R+  EA+R L +++  +                  A
Sbjct: 1788 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1847

Query: 622  ENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
            ENE+  + A +   + +R  EQA Q +  D      +LR    +++E  +  ++     R
Sbjct: 1848 ENERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQR 1906

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAG---SEGAAELE 727
             Q+  ++L  + + E       EL+ +L  R R  A     S+  AELE
Sbjct: 1907 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELE 1954



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 62/229 (27%), Positives = 93/229 (40%), Gaps = 60/229 (26%)

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVV-KMRVKQEE--KLSAALQ--------AK 584
            S L+A +E   +AL   L  K+  ++FL E   KM+   EE  +LS A Q        A+
Sbjct: 2227 SKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2284

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIE--------------RLRAENEKKMKEA 630
              L Q+        KEK++   EA R L+ E E              RL+ + E+  ++ 
Sbjct: 2285 EDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2343

Query: 631  NESRLRLKRELEQARQARVCDKGCEAGRLRAK-----------------YSAQIEDLQVK 673
             E     +R LE  RQ R  +   EA RL+ +                 +  Q E++  K
Sbjct: 2344 AEETQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2402

Query: 674  L--------------QHAEADREQLRADLLREREAREHLEKVVKELQEQ 708
            L              Q  E  R+Q   D  R REA   LE+  ++LQ++
Sbjct: 2403 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2451


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 65/267 (24%), Positives = 119/267 (44%), Gaps = 41/267 (15%)

Query: 473  APEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPA 532
            A E ++ +E E  +E + +   + +   + +      AK+L     R     V    A  
Sbjct: 1383 AEERERLAEVEAALEKQRQLAEAHAQAKAQA---EREAKELQQ---RMQEEVVRREEAAV 1436

Query: 533  DAPS---GLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEK-----LSAALQAK 584
            DA      ++ EL+ LRQ+ E  +  K A++    E  ++R+++E +     L A  + +
Sbjct: 1437 DAQQQKRSIQEELQQLRQSSEAEIQAK-ARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1495

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRA----ENEKKMKEANESRLRLKRE 640
                 EL+ LR     +  EA   KR  ++E ERLR     E+++K +   E   R+K E
Sbjct: 1496 GGAEGELQALRA----RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAE 1551

Query: 641  LEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEK 700
             E AR+ +   +  E               +++LQ  EA+R   +A++ R R+ +  LE 
Sbjct: 1552 AEAAREKQRALQALE---------------ELRLQAEEAERRLRQAEVERARQVQVALET 1596

Query: 701  VVKELQEQLWPRARPEAAGSEGAAELE 727
              +  + +L  +    A+ +E  A+LE
Sbjct: 1597 AQRSAEAELQSK---RASFAEKTAQLE 1620



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 58/215 (26%), Positives = 100/215 (46%), Gaps = 39/215 (18%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            E ELE  RQ  EG    + A E+   E++++R + E+      Q ++ L +EL  L+   
Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQ---ELIRLRAETEQ----GEQQRQLLEEELARLQ--- 1767

Query: 599  KEKLREATEAKRNLRKEIERLRAENE----KKMKEANESRLRLKRELE--QARQARVCDK 652
              +   AT+ ++ L  E+ ++RAE E     K +   ESR   ++  +  +A   R  + 
Sbjct: 1768 -REAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1826

Query: 653  GCEAGRLR-----AKYSAQIEDLQVKLQHAEADR---EQLRA------------DLLRER 692
              EA RLR     AK   Q+ +     Q AEA+R   E+L A              L+E+
Sbjct: 1827 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1886

Query: 693  EAREHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            EA    E++ +  +++ + R R E   ++  A++E
Sbjct: 1887 EAEN--ERLRRLAEDEAFQRRRLEEQAAQHKADIE 1919



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 70/272 (25%), Positives = 120/272 (44%), Gaps = 24/272 (8%)

Query: 466  ETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAV 525
            E L      E  +  +AEVE+ SR +  +  +     +  +    +       R L  A 
Sbjct: 1524 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1583

Query: 526  PDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKM-RVKQEEKLSAAL--- 581
             + A        ++  LE  +++ E  L +K A   F  +  ++ R  QEE ++ A    
Sbjct: 1584 VERARQ------VQVALETAQRSAEAELQSKRAS--FAEKTAQLERSLQEEHVAVAQLRE 1635

Query: 582  QAKRSLHQELEFLRV---AKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLK 638
            +A+R   Q+ E  R    A++E  R   +A   LR    RL+AE   + K   ++    +
Sbjct: 1636 EAERRAQQQAEAERAREEAERELERWQLKANEALRL---RLQAEEVAQQKSLAQAEAEKQ 1692

Query: 639  RELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRA---DLLREREAR 695
            +E E  R+AR   K  E   +R +  A+ ++L+ + Q AE   +Q  A   +L+R R   
Sbjct: 1693 KE-EAEREARRRGK-AEEQAVRQRELAE-QELEKQRQLAEGTAQQRLAAEQELIRLRAET 1749

Query: 696  EHLEKVVKELQEQLWPRARPEAAGSEGAAELE 727
            E  E+  + L+E+L    R  AA ++   ELE
Sbjct: 1750 EQGEQQRQLLEEELARLQREAAAATQKRQELE 1781



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 37/158 (23%), Positives = 77/158 (48%), Gaps = 21/158 (13%)

Query: 568  KMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKM 627
            + R ++ E+L+    A     Q  E    AK +  REA E ++ +++E+ R     E+  
Sbjct: 1380 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR----REEAA 1435

Query: 628  KEANESRLRLKRELEQARQARVCD--------KGCEAGRLRAKYSAQIEDLQVKLQH--- 676
             +A + +  ++ EL+Q RQ+   +        +  E  RLR +   ++  LQ++      
Sbjct: 1436 VDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1495

Query: 677  --AEADREQLRADL----LREREAREHLEKVVKELQEQ 708
              AE + + LRA       ++R+A+E  E++ +++Q++
Sbjct: 1496 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1533



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 50/190 (26%), Positives = 88/190 (46%), Gaps = 26/190 (13%)

Query: 539  EAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAK 598
            EAE    +QA     + + A+E+   E+ + ++K  E L   LQA+    Q+      A+
Sbjct: 1636 EAERRAQQQA-----EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690

Query: 599  KEKLREATEAKRNLRKEIERLR--------AENEKKMKE--------ANESRLRLKRELE 642
            K+K     EA+R  + E + +R         E ++++ E        A +  +RL+ E E
Sbjct: 1691 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1750

Query: 643  QARQARVCDKGCEAGRLRAKYSA---QIEDLQVKLQHAEADREQLRADLLR-EREAREHL 698
            Q  Q R   +  E  RL+ + +A   + ++L+ +L    A+ E L A   R E E+R   
Sbjct: 1751 QGEQQRQLLEE-ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS 1809

Query: 699  EKVVKELQEQ 708
            EK  + L+ +
Sbjct: 1810 EKSKQRLEAE 1819



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/182 (28%), Positives = 83/182 (45%), Gaps = 21/182 (11%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRS 586
            DA    +A + LE E E L+Q         EAK   L       V+QE+ L      ++S
Sbjct: 2471 DAERLREAIAELEREKEKLQQ---------EAKLLQLKSEEMQTVQQEQLLQETQALQQS 2521

Query: 587  LHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQ 646
               E + L   ++E+  E  +AK      +E+L  +   K ++  E + R ++++EQ RQ
Sbjct: 2522 FLSEKDSL--LQRERFIEQEKAK------LEQLFQDEVAKAQQLREEQQRQQQQMEQERQ 2573

Query: 647  ARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQ 706
              V     EA R + +    +   Q +LQ  E  R Q + +LL E   R  L + ++ L+
Sbjct: 2574 RLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQ-QEELLAEENQR--LREQLQLLE 2629

Query: 707  EQ 708
            EQ
Sbjct: 2630 EQ 2631



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 94/449 (20%), Positives = 171/449 (38%), Gaps = 51/449 (11%)

Query: 295  EEQARLGRCLDDVKEKFDYGN----KYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKD 350
            EE ARL    ++ K +         + +    RV +E  A+I   T   +    A  EK+
Sbjct: 1828 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKE 1887

Query: 351  KPSSWLRTLAGSSN------KSLGCVHP---RQRLSAFRPWSPAVSASEKELSPHLPALI 401
              +  LR LA          +     H     +RL+  R       AS+ EL      L+
Sbjct: 1888 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR------KASDSELERQ-KGLV 1940

Query: 402  RDSFYSYKSFETAV-APNVALAPPAQQKVVSSPPCAAAVSRAPEPLATCTQP-----RKR 455
             D+    +  E  + A   +    A  K           S A + L +  Q      R+R
Sbjct: 1941 EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQR 2000

Query: 456  KLTVDTPG----APETLAPVAAPEEDKDSEAEVEVESREEFTSSLSSLSS-PSFTSSSSA 510
            +L  +       A E +    A EE+   + +  +E  E   + +             SA
Sbjct: 2001 QLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESA 2060

Query: 511  KDLGSPGARALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDT----KEAKEKFLHEV 566
            + L      A      +  A A A    E EL+   Q  +  LD      EA  +   E 
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2120

Query: 567  VKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEK- 625
             + RV+ E +   A Q++R + +E E L    K+   E  +A+   +   E+LR E E+ 
Sbjct: 2121 EEARVQAERE---AAQSRRQV-EEAERL----KQSAEEQAQARAQAQAAAEKLRKEAEQE 2172

Query: 626  --KMKEANESRLRLKR--ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
              +  +A ++ LR K+  + E  +  +  +   +  R +A+   ++  L+++L+  +  +
Sbjct: 2173 AARRAQAEQAALRQKQAADAEMEKHKKFAE---QTLRQKAQVEQELTTLRLQLEETDHQK 2229

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLW 710
              L  +L R +       +   +++E+L+
Sbjct: 2230 NLLDEELQRLKAEATEAARQRSQVEEELF 2258



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 57/229 (24%), Positives = 101/229 (44%), Gaps = 30/229 (13%)

Query: 527  DAAAPADAPSGLEAELEHLRQALEGGLDTK---EAKEKFLHEVVKMRVKQE----EKLSA 579
            +AAA       LEAEL  +R  +E  L +K   E + +   E  K R++ E     +L+ 
Sbjct: 1769 EAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828

Query: 580  ALQAKRSLHQELEFLR-VAKKEKLREATEAKRNLRKEIERL-----------------RA 621
                 R+L +E +  R +A+++  R+  EA+R L +++  +                  A
Sbjct: 1829 EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1888

Query: 622  ENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADR 681
            ENE+  + A +   + +R  EQA Q +  D      +LR    +++E  +  ++     R
Sbjct: 1889 ENERLRRLAEDEAFQRRRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQR 1947

Query: 682  EQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAG---SEGAAELE 727
             Q+  ++L  + + E       EL+ +L  R R  A     S+  AELE
Sbjct: 1948 RQVEEEILALKASFEKAAAGKAELELEL-GRIRSNAEDTLRSKEQAELE 1995



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 62/229 (27%), Positives = 93/229 (40%), Gaps = 60/229 (26%)

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVV-KMRVKQEE--KLSAALQ--------AK 584
            S L+A +E   +AL   L  K+  ++FL E   KM+   EE  +LS A Q        A+
Sbjct: 2268 SKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2325

Query: 585  RSLHQELEFLRVAKKEKLREATEAKRNLRKEIE--------------RLRAENEKKMKEA 630
              L Q+        KEK++   EA R L+ E E              RL+ + E+  ++ 
Sbjct: 2326 EDLAQQRALAEKMLKEKMQAVQEATR-LKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2384

Query: 631  NESRLRLKRELEQARQARVCDKGCEAGRLRAK-----------------YSAQIEDLQVK 673
             E     +R LE  RQ R  +   EA RL+ +                 +  Q E++  K
Sbjct: 2385 AEETQGFQRTLEAERQ-RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEK 2443

Query: 674  L--------------QHAEADREQLRADLLREREAREHLEKVVKELQEQ 708
            L              Q  E  R+Q   D  R REA   LE+  ++LQ++
Sbjct: 2444 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQE 2492


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 60/256 (23%), Positives = 109/256 (42%), Gaps = 13/256 (5%)

Query: 476  EDKDSEAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAP 535
            E K  E    +E  EE  + L++         S  K         L     +  A  +  
Sbjct: 916  EAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKV 975

Query: 536  SGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLR 595
              L  E+  L + +      K+A ++   + +     +E+K++   +AK  L Q+++   
Sbjct: 976  KNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVD--- 1032

Query: 596  VAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCE 655
                  L  + E ++ +R ++ER + + E  +K   ES + L+ + +Q  + R+  K  E
Sbjct: 1033 -----DLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDE-RLKKKDFE 1086

Query: 656  AGRLRAKYS---AQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWP- 711
               L A+     A    LQ KL+  +A  E+L  +L  ER AR  +EK+  +L  +L   
Sbjct: 1087 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1146

Query: 712  RARPEAAGSEGAAELE 727
              R E AG   + ++E
Sbjct: 1147 SERLEEAGGATSVQIE 1162



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 46/182 (25%), Positives = 80/182 (43%), Gaps = 18/182 (9%)

Query: 538  LEAELEHLRQALEGGLD---TKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFL 594
            L  EL  L+ A E  L+   T + + K L E +    +Q       +     + ++LE  
Sbjct: 1477 LSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAE 1536

Query: 595  RVAKKEKLREAT-----EAKRNLRKEIE--RLRAENEKKMKEANESRLRLKRELEQARQA 647
            ++  +  L EA      E  + LR ++E  +++AE E+K+ E +E       E+EQA++ 
Sbjct: 1537 KMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDE-------EMEQAKRN 1589

Query: 648  RVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQE 707
             +         L A+  ++ E L+VK +  E D  ++   L          +K VK LQ 
Sbjct: 1590 HLRVVDSLQTSLDAETRSRNEALRVK-KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQS 1648

Query: 708  QL 709
             L
Sbjct: 1649 LL 1650



 Score = 39.3 bits (90), Expect = 0.013
 Identities = 48/188 (25%), Positives = 86/188 (45%), Gaps = 31/188 (16%)

Query: 541  ELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKE 600
            E E L   L  G  T   + + L   ++  VK +  L+ ALQ+ R    + + LR    E
Sbjct: 1293 EKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSAR---HDCDLLR----E 1345

Query: 601  KLREATEAKRNLRK-------EIERLRAENE----KKMKEANESRLRLKRELEQARQA-- 647
            +  E TEAK  L++       E+ + R + E    ++ +E  E++ +L + L++A +A  
Sbjct: 1346 QYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVE 1405

Query: 648  RVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEA-----DREQLRADLL------REREARE 696
             V  K     + + +   +IEDL V ++ + A     D++Q   D +      +  E++ 
Sbjct: 1406 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465

Query: 697  HLEKVVKE 704
             LE   KE
Sbjct: 1466 ELESSQKE 1473



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 40/187 (21%), Positives = 78/187 (41%), Gaps = 36/187 (19%)

Query: 538  LEAELEHL-RQALEGGLDTKEAKEKF------LHEVVKMRVKQEEKLSAALQAKRSLHQE 590
            +E +L H  R A E     K  +         L + V+     +E ++   +    L  E
Sbjct: 1625 MEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAE 1684

Query: 591  LEFLRVAKKEKLREATEAKRNLRKEIERLR--------AENEKKMKEANESRLRLKRELE 642
            LE LR   ++  R    A++ L +  ER++          N+KK  +A+ S  +L+ E+E
Sbjct: 1685 LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLS--QLQTEVE 1742

Query: 643  QARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVV 702
            +A Q                   +  + + K + A  D   +  +L +E++   HLE++ 
Sbjct: 1743 EAVQ-------------------ECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK 1783

Query: 703  KELQEQL 709
            K +++ +
Sbjct: 1784 KNMEQTI 1790



 Score = 34.3 bits (77), Expect = 0.42
 Identities = 41/189 (21%), Positives = 82/189 (43%), Gaps = 39/189 (20%)

Query: 538  LEAELEHLRQALEGGL----DTKEAKEKFLHEVVKM--RVKQEEKLSAALQA-KRSLHQE 590
            ++A+L  L+  +E  +    + +E  +K + +   M   +K+E+  SA L+  K+++ Q 
Sbjct: 1730 MDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQT 1789

Query: 591  LEFLR-----------VAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKR 639
            ++ L+              K++L++     R L  E+E  +  N + +K   +S  R+K 
Sbjct: 1790 IKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKE 1849

Query: 640  ELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQ--------HAEADREQLRADLLRE 691
               Q  + R             K   +++DL  KLQ         AE   EQ   +L + 
Sbjct: 1850 LTYQTEEDR-------------KNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1896

Query: 692  REAREHLEK 700
            R+ +  L++
Sbjct: 1897 RKVQHELDE 1905



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 41/187 (21%), Positives = 76/187 (40%), Gaps = 20/187 (10%)

Query: 541  ELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKE 600
            E E   +A+     + E  +  L   ++  +   E+ +AA  A     +  + +    K+
Sbjct: 1399 EAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1458

Query: 601  KLREATEAKRNLRKEIERLRAENEKKMKEANESRLR----LKRELEQARQARVCDKGCEA 656
            K  E+     + +KE   L  E   K+K A E  L      KRE  +  Q  + D   + 
Sbjct: 1459 KYEESQSELESSQKEARSLSTE-LFKLKNAYEESLEHLETFKRE-NKNLQEEISDLTEQL 1516

Query: 657  G----------RLRAKYSAQIEDLQVKLQHAEADREQLRADLLRER----EAREHLEKVV 702
            G          ++R +  A+  +LQ  L+ AEA  E     +LR +    + +  +E+ +
Sbjct: 1517 GSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKL 1576

Query: 703  KELQEQL 709
             E  E++
Sbjct: 1577 AEKDEEM 1583



 Score = 31.6 bits (70), Expect = 2.7
 Identities = 30/92 (32%), Positives = 44/92 (47%), Gaps = 11/92 (11%)

Query: 621 AENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAE-- 678
           AE EK+M    E   RLK  LE++   R      E          +  DLQ+++Q  +  
Sbjct: 843 AEREKEMASMKEEFTRLKEALEKSEARRK-----ELEEKMVSLLQEKNDLQLQVQAEQDN 897

Query: 679 -ADREQLRADLLREREAREHLEKVVKELQEQL 709
            AD E+ R D L + + +  LE  VKE+ E+L
Sbjct: 898 LADAEE-RCDQLIKNKIQ--LEAKVKEMNERL 926


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 61/195 (31%), Positives = 96/195 (49%), Gaps = 27/195 (13%)

Query: 543 EHLRQALEGGLDTKEAKEKFLH---EVVKMRVKQEEKLSAA--LQAKRSLHQELEFLRVA 597
           E   +A E  L  ++AK+K      E V+ R KQEE+      LQ +    +  E L+  
Sbjct: 608 EKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKK 667

Query: 598 KKE---KLREATEAKR------NLRKEIERLRAENEKKMKEANESRLRLKRELEQARQAR 648
           K+E   +LR+A EAKR        R+E ER   E E++ +E  E   R     EQ RQ  
Sbjct: 668 KEEEQERLRKAAEAKRLAEQREQERREQER--REQERREQERREQERR-----EQERQLA 720

Query: 649 VCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQ 708
             ++  E  RL+A+   Q  +  ++LQ     +EQL+ +L  +++  E      ++LQE+
Sbjct: 721 EQERRREQERLQAERELQEREKALRLQ-----KEQLQRELEEKKKKEEQQRLAERQLQEE 775

Query: 709 LWPRARPEAAGSEGA 723
              +A+ EAAG+  A
Sbjct: 776 QEKKAK-EAAGASKA 789



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 52/190 (27%), Positives = 95/190 (50%), Gaps = 24/190 (12%)

Query: 542 LEHLRQALEGG-LDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQ---------EL 591
           LE+LR+  E   L  ++ +E     + ++++K+EE+L   LQA+  + Q         E 
Sbjct: 542 LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQ 601

Query: 592 EFLRV------AKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLR-LKRELEQA 644
           +F ++      AK+E+L E    K+   K++E + A   ++ +E    RLR L++E E+ 
Sbjct: 602 KFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEA---RRKQEEEARRLRWLQQEEEER 658

Query: 645 RQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKE 704
           R   +  K  E  + R + +A+ + L    Q  +  REQ R +  +ER  +E  E+  +E
Sbjct: 659 RHQELLQKKKEEEQERLRKAAEAKRLAE--QREQERREQERRE--QERREQERREQERRE 714

Query: 705 LQEQLWPRAR 714
            + QL  + R
Sbjct: 715 QERQLAEQER 724



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 35/150 (23%), Positives = 74/150 (49%), Gaps = 10/150 (6%)

Query: 560 EKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKEKLREATEAKRNLRKEIERL 619
           EK    +  +R K+E +     + +    + LE +++ ++E+LR+  +A+       ER+
Sbjct: 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR-------ERV 588

Query: 620 RAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEA 679
               E+K K+  +   ++  + E+A++ R+ ++  +  +  AK   ++E    + Q  EA
Sbjct: 589 EQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKK-KAAAKKMEEVE--ARRKQEEEA 645

Query: 680 DREQLRADLLREREAREHLEKVVKELQEQL 709
            R +       ER  +E L+K  +E QE+L
Sbjct: 646 RRLRWLQQEEEERRHQELLQKKKEEEQERL 675


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,365,674
Number of Sequences: 37866
Number of extensions: 1773962
Number of successful extensions: 19246
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 343
Number of HSP's successfully gapped in prelim test: 1164
Number of HSP's that attempted gapping in prelim test: 12145
Number of HSP's gapped (non-prelim): 6327
length of query: 728
length of database: 18,247,518
effective HSP length: 110
effective length of query: 618
effective length of database: 14,082,258
effective search space: 8702835444
effective search space used: 8702835444
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.