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Search of human proteins with 4506889
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506889 mitogen-activated protein kinase kinase 4 [Homo
sapiens]
(399 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens] 816 0.0
gi|14589900 mitogen-activated protein kinase kinase 6 [Homo sapi... 355 5e-98
gi|21618349 mitogen-activated protein kinase kinase 3 isoform B ... 342 3e-94
gi|21618347 mitogen-activated protein kinase kinase 3 isoform A ... 340 1e-93
gi|21735544 mitogen-activated protein kinase kinase 7 [Homo sapi... 293 2e-79
gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens] 261 6e-70
gi|239751247 PREDICTED: similar to mitogen-activated protein kin... 213 3e-55
gi|21729895 mitogen-activated protein kinase kinase 5 isoform A ... 205 5e-53
gi|13489054 mitogen-activated protein kinase kinase 2 [Homo sapi... 203 3e-52
gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens] 200 2e-51
gi|4506101 mitogen-activated protein kinase kinase 5 isoform B [... 188 8e-48
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 157 1e-38
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 155 5e-38
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 148 7e-36
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 148 1e-35
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 146 4e-35
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 143 2e-34
gi|41281453 serine/threonine kinase 2 [Homo sapiens] 141 9e-34
gi|145275208 myosin IIIA [Homo sapiens] 138 1e-32
gi|126362971 serine/threonine kinase 10 [Homo sapiens] 137 2e-32
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 132 4e-31
gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo sa... 132 4e-31
gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo sa... 132 4e-31
gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo sa... 132 4e-31
gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo sa... 132 4e-31
gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo sa... 132 4e-31
gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo sa... 132 4e-31
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 132 4e-31
gi|134288915 myosin IIIB isoform 1 [Homo sapiens] 132 6e-31
gi|134288892 myosin IIIB isoform 2 [Homo sapiens] 132 6e-31
>gi|4506889 mitogen-activated protein kinase kinase 4 [Homo sapiens]
Length = 399
Score = 816 bits (2108), Expect = 0.0
Identities = 399/399 (100%), Positives = 399/399 (100%)
Query: 1 MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT 60
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT
Sbjct: 1 MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFT 60
Query: 61 LNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV 120
LNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV
Sbjct: 61 LNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMV 120
Query: 121 HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL 180
HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL
Sbjct: 121 HKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMEL 180
Query: 181 MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS 240
MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS
Sbjct: 181 MSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS 240
Query: 241 GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL 300
GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
Sbjct: 241 GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL 300
Query: 301 ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE 360
ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE
Sbjct: 301 ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE 360
Query: 361 LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD 399
LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
Sbjct: 361 LLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD 399
>gi|14589900 mitogen-activated protein kinase kinase 6 [Homo
sapiens]
Length = 334
Score = 355 bits (910), Expect = 5e-98
Identities = 174/317 (54%), Positives = 226/317 (71%), Gaps = 5/317 (1%)
Query: 69 QNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIM 128
+ P ++S + I Q+++ A+DL+ + E+GRGAYG V KM H PSGQIM
Sbjct: 21 EQPQTSSTPPRDLDSKACISIG-NQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIM 79
Query: 129 AVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKF 188
AVKRIR+TV+ +EQK+LLMDLD+ MR+ DCP+ V FYGALFREGD WICMELM TS DKF
Sbjct: 80 AVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKF 139
Query: 189 YKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDF 248
YK V IPE+ILGKI ++ VKAL HL L +IHRD+KPSN+L++ G +K+CDF
Sbjct: 140 YKQVIDK-GQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF 198
Query: 249 GISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYP 308
GISG LVDS+AKT DAGC+PYMAPERI+P +++GY V+SD+WSLGIT+ ELA RFPY
Sbjct: 199 GISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYD 258
Query: 309 KWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFIL 368
W + F QL QVV+ PQL +FS F++F + CL K+ +RP Y EL++HPF
Sbjct: 259 SWGTPFQQLKQVVEEPSPQLPAD---KFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315
Query: 369 MYEERAVEVACYVCKIL 385
++E + +VA +V IL
Sbjct: 316 LHESKGTDVASFVKLIL 332
>gi|21618349 mitogen-activated protein kinase kinase 3 isoform B
[Homo sapiens]
Length = 347
Score = 342 bits (878), Expect = 3e-94
Identities = 182/369 (49%), Positives = 251/369 (68%), Gaps = 33/369 (8%)
Query: 26 SPAPGHPA-VSSMQGK---RKALKLN-FANPPFKSTARFTLNPNPTGVQNPHIERLRTHS 80
SPA PA + +GK +K L+++ + PP PNPT +N
Sbjct: 3 SPASSQPASMPQSKGKSKRKKDLRISCMSKPPA---------PNPTPPRN---------- 43
Query: 81 IESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEK 140
++S + I +++++ A+DL + E+GRGAYG V K+ H SG IMAVKRIR+TV+ +
Sbjct: 44 LDSRTFITIG-DRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQ 102
Query: 141 EQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDD-- 198
EQK+LLMDLD+ MR+ DC Y V FYGALFREGD WICMELM TS DKFY+ VLD
Sbjct: 103 EQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYR---KVLDKNM 159
Query: 199 VIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSI 258
IPE+ILG+I ++ V+AL HL L +IHRD+KPSN+L+++ G++K+CDFGISG LVDS+
Sbjct: 160 TIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSV 219
Query: 259 AKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLT 318
AKT DAGC+PYMAPERI+P +++GY+V+SDVWSLGIT+ E+A RFPY W + F QL
Sbjct: 220 AKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLK 279
Query: 319 QVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVA 378
QVV+ PQL FSP F++F CL K+ ++R Y EL++HPF +++ + ++A
Sbjct: 280 QVVEEPSPQLPAD---RFSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIA 336
Query: 379 CYVCKILDQ 387
+V +IL +
Sbjct: 337 AFVKEILGE 345
>gi|21618347 mitogen-activated protein kinase kinase 3 isoform A
[Homo sapiens]
Length = 318
Score = 340 bits (873), Expect = 1e-93
Identities = 171/327 (52%), Positives = 233/327 (71%), Gaps = 19/327 (5%)
Query: 63 PNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHK 122
PNPT +N ++S + I +++++ A+DL + E+GRGAYG V K+ H
Sbjct: 7 PNPTPPRN----------LDSRTFITIG-DRNFEVEADDLVTISELGRGAYGVVEKVRHA 55
Query: 123 PSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMS 182
SG IMAVKRIR+TV+ +EQK+LLMDLD+ MR+ DC Y V FYGALFREGD WICMELM
Sbjct: 56 QSGTIMAVKRIRATVNSQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMD 115
Query: 183 TSFDKFYKYVYSVLDD--VIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS 240
TS DKFY+ VLD IPE+ILG+I ++ V+AL HL L +IHRD+KPSN+L+++
Sbjct: 116 TSLDKFYR---KVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKE 172
Query: 241 GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL 300
G++K+CDFGISG LVDS+AKT DAGC+PYMAPERI+P +++GY+V+SDVWSLGIT+ E+
Sbjct: 173 GHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEM 232
Query: 301 ATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKE 360
A RFPY W + F QL QVV+ PQL FSP F++F CL K+ ++R Y E
Sbjct: 233 AILRFPYESWGTPFQQLKQVVEEPSPQLPAD---RFSPEFVDFTAQCLRKNPAERMSYLE 289
Query: 361 LLKHPFILMYEERAVEVACYVCKILDQ 387
L++HPF +++ + ++A +V +IL +
Sbjct: 290 LMEHPFFTLHKTKKTDIAAFVKEILGE 316
>gi|21735544 mitogen-activated protein kinase kinase 7 [Homo
sapiens]
Length = 419
Score = 293 bits (750), Expect = 2e-79
Identities = 159/317 (50%), Positives = 212/317 (66%), Gaps = 8/317 (2%)
Query: 65 PTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPS 124
P +++ I++ ++ +G L I Q + DL++LGE+G G G V KM + +
Sbjct: 84 PRSMESIEIDQKLQEIMKQTGYLTIGG-QRYQAEINDLENLGEMGSGTCGQVWKMRFRKT 142
Query: 125 GQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTS 184
G ++AVK++R + +++E K++LMDLDVV++S DCPYIVQ +G D +I MELM T
Sbjct: 143 GHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTC 202
Query: 185 FDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIK 244
+K K + IPE ILGK+T+A VKAL +LKE +IHRD+KPSNILLD G IK
Sbjct: 203 AEKLKKR----MQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIK 258
Query: 245 LCDFGISGQLVDSIAKTRDAGCRPYMAPERID-PSASRQGYDVRSDVWSLGITLYELATG 303
LCDFGISG+LVDS AKTR AGC YMAPERID P ++ YD+R+DVWSLGI+L ELATG
Sbjct: 259 LCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATG 318
Query: 304 RFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLK 363
+FPY + F+ LT+V++ +PP L FS F +FV CLTKD KRPKY +LL+
Sbjct: 319 QFPYKNCKTDFEVLTKVLQEEPPLLPG--HMGFSGDFQSFVKDCLTKDHRKRPKYNKLLE 376
Query: 364 HPFILMYEERAVEVACY 380
H FI YE V+VA +
Sbjct: 377 HSFIKRYETLEVDVASW 393
>gi|239757989 PREDICTED: similar to MAP kinase 3c [Homo sapiens]
Length = 353
Score = 261 bits (668), Expect = 6e-70
Identities = 133/237 (56%), Positives = 174/237 (73%), Gaps = 16/237 (6%)
Query: 63 PNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHK 122
PNPT +N ++S + I + +++ A+DL + E+GRGAYG V K+ H
Sbjct: 41 PNPTTPRN----------LDSRTFITIG-DTNFEVEADDLVTIPELGRGAYGVVEKVRHT 89
Query: 123 PSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMS 182
SG IMAVK I +TV+ EQK+LLMDLD+ MR+ DC Y V FYGALFREGD WICMELM
Sbjct: 90 QSGTIMAVKLIWATVNSXEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMD 149
Query: 183 TSFDKFYKYVYSVLDD--VIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRS 240
TS DKFY+ VLD IPE+ILG+I ++ V+AL HL L +IHRD+KPSN+L+++
Sbjct: 150 TSLDKFYR---KVLDKNMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKE 206
Query: 241 GNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITL 297
G++K+CDFGISG LVDS+AK DAGC+PYMAPERI+P +++GY+V+SDVWSLGIT+
Sbjct: 207 GHVKMCDFGISGYLVDSVAKMMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITM 263
>gi|239751247 PREDICTED: similar to mitogen-activated protein kinase
kinase 3 [Homo sapiens]
Length = 198
Score = 213 bits (541), Expect = 3e-55
Identities = 99/156 (63%), Positives = 127/156 (81%), Gaps = 5/156 (3%)
Query: 147 MDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDD--VIPEEI 204
MDLD+ MR+ DC Y V FYGALFREGD WICMELM TS DKFY+ VLD IPE+I
Sbjct: 1 MDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYR---KVLDKNMTIPEDI 57
Query: 205 LGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDA 264
LG+I ++ V+AL HL L +IHRD+KPSN+L+++ G++K+CDFGISG LVDS+AKT DA
Sbjct: 58 LGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDA 117
Query: 265 GCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL 300
GC+PYMAPERI+P +++GY+V+SDVWSLGIT+ ++
Sbjct: 118 GCKPYMAPERINPELNQKGYNVKSDVWSLGITMQKV 153
>gi|21729895 mitogen-activated protein kinase kinase 5 isoform A
[Homo sapiens]
Length = 448
Score = 205 bits (522), Expect = 5e-53
Identities = 125/304 (41%), Positives = 178/304 (58%), Gaps = 27/304 (8%)
Query: 100 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 159
+D++ +G G G+V K H PSG+I+AVK I + + QKQ++ +L+++ + D
Sbjct: 164 QDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSS 222
Query: 160 YIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITLATVKALNH 218
YI+ FYGA F E IC E M S D + K +PE +LG+I +A VK L +
Sbjct: 223 YIIGFYGAFFVENRISICTEFMDGGSLDVYRK---------MPEHVLGRIAVAVVKGLTY 273
Query: 219 LKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPS 278
L +LKI+HRD+KPSN+L++ G +KLCDFG+S QLV+SIAKT G YMAPERI
Sbjct: 274 LW-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERI--- 328
Query: 279 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWNS------VFDQLTQVVKGDPPQLSNSE 332
S + Y + SDVWSLGI+ ELA GRFPYP+ L +V D P L
Sbjct: 329 -SGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPVG- 386
Query: 333 EREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEE-RAVEVACYVCKILDQMPAT 391
EFS F++F+ C+ K +RP +EL+ HPFI+ + + A V+ +VC+ L++ +
Sbjct: 387 --EFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQ 444
Query: 392 PSSP 395
P
Sbjct: 445 QGPP 448
>gi|13489054 mitogen-activated protein kinase kinase 2 [Homo
sapiens]
Length = 400
Score = 203 bits (516), Expect = 3e-52
Identities = 127/341 (37%), Positives = 182/341 (53%), Gaps = 61/341 (17%)
Query: 100 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 159
+D + + E+G G G V K+ H+PSG IMA K I + + Q++ +L V + + P
Sbjct: 70 DDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQV-LHECNSP 128
Query: 160 YIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITLATVKALNH 218
YIV FYGA + +G+ ICME M S D+ K IPEEILGK+++A ++ L +
Sbjct: 129 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKR-----IPEEILGKVSIAVLRGLAY 183
Query: 219 LKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPS 278
L+E +I+HRD+KPSNIL++ G IKLCDFG+SGQL+DS+A + G R YMAPER+ +
Sbjct: 184 LREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMAPERLQGT 242
Query: 279 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWN--------------------------- 311
Y V+SD+WS+G++L ELA GR+P P +
Sbjct: 243 ----HYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRP 298
Query: 312 ------------------SVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDES 353
++F+ L +V PP+L N F+P F FVN CL K+ +
Sbjct: 299 RPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNG---VFTPDFQEFVNKCLIKNPA 355
Query: 354 KRPKYKELLKHPFILMYEERAVEVACYVCKILD-QMPATPS 393
+R K L H FI E V+ A ++CK L P TP+
Sbjct: 356 ERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPGTPT 396
>gi|5579478 mitogen-activated protein kinase kinase 1 [Homo sapiens]
Length = 393
Score = 200 bits (509), Expect = 2e-51
Identities = 122/337 (36%), Positives = 184/337 (54%), Gaps = 57/337 (16%)
Query: 100 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 159
+D + + E+G G G V K+ HKPSG +MA K I + + Q++ +L V + + P
Sbjct: 66 DDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQV-LHECNSP 124
Query: 160 YIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITLATVKALNH 218
YIV FYGA + +G+ ICME M S D+ K IPE+ILGK+++A +K L +
Sbjct: 125 YIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGR-----IPEQILGKVSIAVIKGLTY 179
Query: 219 LKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPS 278
L+E KI+HRD+KPSNIL++ G IKLCDFG+SGQL+DS+A + G R YM+PER+ +
Sbjct: 180 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANS-FVGTRSYMSPERLQGT 238
Query: 279 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWN--------------------------- 311
Y V+SD+WS+G++L E+A GR+P P +
Sbjct: 239 ----HYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPG 294
Query: 312 --------------SVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPK 357
++F+ L +V PP+L + FS F +FVN CL K+ ++R
Sbjct: 295 RPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSG---VFSLEFQDFVNKCLIKNPAERAD 351
Query: 358 YKELLKHPFILMYEERAVEVACYVCKILD-QMPATPS 393
K+L+ H FI + V+ A ++C + P+TP+
Sbjct: 352 LKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPT 388
>gi|4506101 mitogen-activated protein kinase kinase 5 isoform B
[Homo sapiens]
Length = 438
Score = 188 bits (477), Expect = 8e-48
Identities = 120/300 (40%), Positives = 175/300 (58%), Gaps = 29/300 (9%)
Query: 100 EDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCP 159
+D++ +G G G+V K H PSG+I+AVK I + + QKQ++ +L+++ + D
Sbjct: 164 QDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSS 222
Query: 160 YIVQFYGALFREGDCWICMELMST-SFDKFYKYVYSVLDDVIPEEILGKITLATVKALNH 218
YI+ FYGA F E IC E M S D + K +PE +LG+I +A VK L +
Sbjct: 223 YIIGFYGAFFVENRISICTEFMDGGSLDVYRK---------MPEHVLGRIAVAVVKGLTY 273
Query: 219 LKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPS 278
L +LKI+HRD+KPSN+L++ G +KLCDFG+S QLV+SIAKT G YMAPERI
Sbjct: 274 LW-SLKILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTY-VGTNAYMAPERI--- 328
Query: 279 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFD-QLTQ-VVKGDPPQLSNSEEREF 336
S + Y + SDVWSLGI+ E+ + S+ QL Q +V D P L EF
Sbjct: 329 -SGEQYGIHSDVWSLGISFMEIQKNQ------GSLMPLQLLQCIVDEDSPVLPVG---EF 378
Query: 337 SPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEE-RAVEVACYVCKILDQMPATPSSP 395
S F++F+ C+ K +RP +EL+ HPFI+ + + A V+ +VC+ L++ + P
Sbjct: 379 SEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNAAVVSMWVCRALEERRSQQGPP 438
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 157 bits (398), Expect = 1e-38
Identities = 100/284 (35%), Positives = 160/284 (56%), Gaps = 17/284 (5%)
Query: 86 KLKISPEQHWDFTAEDLKD-LGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQ 144
KLK E E++ D L ++G G+YGSV K +HK SGQ++A+K++ E + ++
Sbjct: 10 KLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV---ESDLQE 66
Query: 145 LLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEI 204
++ ++ + M+ D PY+V++YG+ F+ D WI ME + + + + E+
Sbjct: 67 IIKEISI-MQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGS---VSDIIRLRNKTLIEDE 122
Query: 205 LGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDA 264
+ I +T+K L +L ++ IHRDIK NILL+ G+ KL DFG++GQL D++AK
Sbjct: 123 IATILKSTLKGLEYL-HFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTV 181
Query: 265 GCRPY-MAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG 323
P+ MAPE I GY+ +D+WSLGIT E+A G+ PY + + + ++
Sbjct: 182 IGTPFWMAPEVI----QEIGYNCVADIWSLGITSIEMAEGKPPYADIHPM--RAIFMIPT 235
Query: 324 DPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI 367
+PP E +S F +FV CL K+ +R +LL+HPFI
Sbjct: 236 NPPPTFRKPEL-WSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 278
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 155 bits (393), Expect = 5e-38
Identities = 100/301 (33%), Positives = 167/301 (55%), Gaps = 26/301 (8%)
Query: 68 VQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQI 127
++NP +L+ +S K PE+ +D L ++G G+YGSV K +HK +GQI
Sbjct: 6 LRNPPRRQLKKLDEDSLTK---QPEEVFDV-------LEKLGEGSYGSVYKAIHKETGQI 55
Query: 128 MAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDK 187
+A+K++ E + ++++ ++ + M+ D P++V++YG+ F+ D WI ME
Sbjct: 56 VAIKQVPV---ESDLQEIIKEISI-MQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGS-- 109
Query: 188 FYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCD 247
+ + + + E+ + I +T+K L +L ++ IHRDIK NILL+ G+ KL D
Sbjct: 110 -VSDIIRLRNKTLTEDEIATILQSTLKGLEYL-HFMRKIHRDIKAGNILLNTEGHAKLAD 167
Query: 248 FGISGQLVDSIAKTRDAGCRPY-MAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFP 306
FG++GQL D++AK P+ MAPE I GY+ +D+WSLGIT E+A G+ P
Sbjct: 168 FGVAGQLTDTMAKRNTVIGTPFWMAPEVI----QEIGYNCVADIWSLGITAIEMAEGKPP 223
Query: 307 YPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPF 366
Y + + + ++ +PP E +S +F +FV CL K +R +LL+HPF
Sbjct: 224 YADIHPM--RAIFMIPTNPPPTFRKPEL-WSDNFTDFVKQCLVKSPEQRATATQLLQHPF 280
Query: 367 I 367
+
Sbjct: 281 V 281
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 148 bits (374), Expect = 7e-36
Identities = 107/309 (34%), Positives = 159/309 (51%), Gaps = 36/309 (11%)
Query: 84 SGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQK 143
S LK PE E L +IG+G++G V K + + +++A+K I E E +
Sbjct: 25 STNLKADPE-------ELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIE 77
Query: 144 QLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIP-- 201
+ ++ V+ D PY+ ++YG+ ++ WI ME + S LD + P
Sbjct: 78 DIQQEI-TVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGG---------SALDLLEPGP 127
Query: 202 --EEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDS-I 258
E + I +K L++L KI HRDIK +N+LL G +KL DFG++GQL D+ I
Sbjct: 128 LDETQIATILREILKGLDYLHSEKKI-HRDIKAANVLLSEHGEVKLADFGVAGQLTDTQI 186
Query: 259 AKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLT 318
+ G +MAPE I SA YD ++D+WSLGIT ELA G P+ + + + L
Sbjct: 187 KRNTFVGTPFWMAPEVIKQSA----YDSKADIWSLGITAIELARGEPPHSELHPM-KVLF 241
Query: 319 QVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVA 378
+ K +PP L E +S FV CL K+ S RP KELLKH FIL R +
Sbjct: 242 LIPKNNPPTL----EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFIL----RNAKKT 293
Query: 379 CYVCKILDQ 387
Y+ +++D+
Sbjct: 294 SYLTELIDR 302
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 148 bits (373), Expect = 1e-35
Identities = 110/319 (34%), Positives = 162/319 (50%), Gaps = 41/319 (12%)
Query: 79 HSIESSG-----KLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRI 133
HS SG LK PE E L +IG+G++G V K + + +++A+K I
Sbjct: 3 HSPVQSGLPGMQNLKADPE-------ELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKII 55
Query: 134 RSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVY 193
E E + + ++ V+ D PY+ ++YG+ ++ WI ME +
Sbjct: 56 DLEEAEDEIEDIQQEI-TVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGG--------- 105
Query: 194 SVLDDVIP----EEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFG 249
S LD + P E + I +K L++L KI HRDIK +N+LL G +KL DFG
Sbjct: 106 SALDLLEPGPLDETQIATILREILKGLDYLHSEKKI-HRDIKAANVLLSEHGEVKLADFG 164
Query: 250 ISGQLVDS-IAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYP 308
++GQL D+ I + G +MAPE I SA YD ++D+WSLGIT ELA G P+
Sbjct: 165 VAGQLTDTQIKRNTFVGTPFWMAPEVIKQSA----YDSKADIWSLGITAIELARGEPPHS 220
Query: 309 KWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFIL 368
+ + + L + K +PP L E +S FV CL K+ S RP KELLKH FIL
Sbjct: 221 ELHPM-KVLFLIPKNNPPTL----EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFIL 275
Query: 369 MYEERAVEVACYVCKILDQ 387
R + Y+ +++D+
Sbjct: 276 ----RNAKKTSYLTELIDR 290
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 146 bits (368), Expect = 4e-35
Identities = 103/287 (35%), Positives = 147/287 (51%), Gaps = 26/287 (9%)
Query: 93 QHWDFTAEDL-KDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDV 151
QH E+L L IG+G++G V K + + +++A+K I E E + + ++
Sbjct: 10 QHSRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEI-T 68
Query: 152 VMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIP----EEILGK 207
V+ D PYI +++G+ + WI ME + S LD + P E +
Sbjct: 69 VLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGG---------SALDLLKPGPLEETYIAT 119
Query: 208 ITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDS-IAKTRDAGC 266
I +K L++L KI HRDIK +N+LL G++KL DFG++GQL D+ I + G
Sbjct: 120 ILREILKGLDYLHSERKI-HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGT 178
Query: 267 RPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPP 326
+MAPE I SA YD ++D+WSLGIT ELA G P + + L + K PP
Sbjct: 179 PFWMAPEVIKQSA----YDFKADIWSLGITAIELAKGEPPNSDLHPM-RVLFLIPKNSPP 233
Query: 327 QLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEER 373
L E + S F FV CL KD RP KELLKH FI Y ++
Sbjct: 234 TL----EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKK 276
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 143 bits (361), Expect = 2e-34
Identities = 99/294 (33%), Positives = 155/294 (52%), Gaps = 41/294 (13%)
Query: 105 LGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQF 164
L IG+G++G V K + + Q++A+K I E E + + ++ V+ D Y+ ++
Sbjct: 27 LERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEI-TVLSQCDSSYVTKY 85
Query: 165 YGALFREGDCWICME----------LMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVK 214
YG+ + WI ME L + FD+F + ++L +++ K
Sbjct: 86 YGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQ--IATMLKEIL-------------K 130
Query: 215 ALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDS-IAKTRDAGCRPYMAPE 273
L++L KI HRDIK +N+LL G++KL DFG++GQL D+ I + G +MAPE
Sbjct: 131 GLDYLHSEKKI-HRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 189
Query: 274 RIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEE 333
I SA YD ++D+WSLGIT ELA G P + + L + K +PP L
Sbjct: 190 VIQQSA----YDSKADIWSLGITAIELAKGEPPNSDMHPM-RVLFLIPKNNPPTLVG--- 241
Query: 334 REFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQ 387
+F+ SF F++ CL KD S RP KELLKH FI+ ++ Y+ +++D+
Sbjct: 242 -DFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKK----TSYLTELIDR 290
>gi|41281453 serine/threonine kinase 2 [Homo sapiens]
Length = 1235
Score = 141 bits (356), Expect = 9e-34
Identities = 96/293 (32%), Positives = 161/293 (54%), Gaps = 20/293 (6%)
Query: 86 KLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQL 145
K ++PE W+ +GE+G GA+G V K +K + ++A ++ T E+E +
Sbjct: 25 KRDLNPEDFWEI-------IGELGDGAFGKVYKAQNKETS-VLAAAKVIDTKSEEELEDY 76
Query: 146 LMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEIL 205
++++D+ + S D P IV+ A + E + WI +E + V L+ + E +
Sbjct: 77 MVEIDI-LASCDHPNIVKLLDAFYYENNLWILIEFCAGGA---VDAVMLELERPLTESQI 132
Query: 206 GKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDA- 264
+ T+ ALN+L +N KIIHRD+K NIL G+IKL DFG+S + +I + RD+
Sbjct: 133 QVVCKQTLDALNYLHDN-KIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQR-RDSF 190
Query: 265 -GCRPYMAPERIDPSASR-QGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK 322
G +MAPE + S+ + YD ++DVWSLGITL E+A P+ + N + L ++ K
Sbjct: 191 IGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPM-RVLLKIAK 249
Query: 323 GDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAV 375
+PP L ++ +S +F +F+ CL K+ R +LL+HPF+ + + +
Sbjct: 250 SEPPTL--AQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPI 300
>gi|145275208 myosin IIIA [Homo sapiens]
Length = 1616
Score = 138 bits (347), Expect = 1e-32
Identities = 102/294 (34%), Positives = 149/294 (50%), Gaps = 24/294 (8%)
Query: 91 PEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLD 150
P W+ T IG+G YG V K+++K +GQ AVK + D E+ + + +
Sbjct: 17 PSDTWEITET-------IGKGTYGKVFKVLNKKNGQKAAVKILDPIHDIDEEIEA--EYN 67
Query: 151 VVMRSSDCPYIVQFYGALFRE----GD-CWICMELMSTSFDKFYKYVYSVLDDVIPEEIL 205
++ SD P +V+FYG F++ GD W+ +EL S + + + E ++
Sbjct: 68 ILKALSDHPNVVRFYGIYFKKDKVNGDKLWLVLELCSGGSVTDLVKGFLKRGERMSEPLI 127
Query: 206 GKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAG 265
I + L HL N K IHRD+K +NILL G +KL DFG+S QL + + +
Sbjct: 128 AYILHEALMGLQHLHNN-KTIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRHRRNTSV 186
Query: 266 CRPY-MAPERIDPSASRQ---GYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVV 321
P+ MAPE I + +Q YD R D WSLGIT EL G P + + L ++
Sbjct: 187 GTPFWMAPEVI--ACEQQLDTTYDARCDTWSLGITAIELGDGDPPLADLHPM-RALFKIP 243
Query: 322 KGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAV 375
+ PP+L E +S F +F++ CLTKD KRP ELL+H FI E + V
Sbjct: 244 RNPPPKLRQPE--LWSAEFNDFISKCLTKDYEKRPTVSELLQHKFITQIEGKDV 295
>gi|126362971 serine/threonine kinase 10 [Homo sapiens]
Length = 968
Score = 137 bits (344), Expect = 2e-32
Identities = 91/282 (32%), Positives = 153/282 (54%), Gaps = 20/282 (7%)
Query: 89 ISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMD 148
+ P + W+ +GE+G GA+G V K +K +G + A K I T E+E + +++
Sbjct: 30 LDPNEVWEI-------VGELGDGAFGKVYKAKNKETGALAAAKVIE-TKSEEELEDYIVE 81
Query: 149 LDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKI 208
+++ + + D PYIV+ GA + +G WI +E + LD + E + +
Sbjct: 82 IEI-LATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGA---VDAIMLELDRGLTEPQIQVV 137
Query: 209 TLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDA--GC 266
++ALN L +IIHRD+K N+L+ G+I+L DFG+S + + ++ K RD+ G
Sbjct: 138 CRQMLEALNFLHSK-RIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQK-RDSFIGT 195
Query: 267 RPYMAPERIDPSASRQ-GYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDP 325
+MAPE + + YD ++D+WSLGITL E+A P+ + N + L ++ K DP
Sbjct: 196 PYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPM-RVLLKIAKSDP 254
Query: 326 PQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI 367
P L ++S F +F+ + L K+ RP +LL+HPF+
Sbjct: 255 PTLLTPS--KWSVEFRDFLKIALDKNPETRPSAAQLLEHPFV 294
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 132 bits (333), Expect = 4e-31
Identities = 88/271 (32%), Positives = 145/271 (53%), Gaps = 23/271 (8%)
Query: 108 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGA 167
+G G YG V K H +GQ+ A+K + T DE+E+ + +++++ + S I +YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 168 LFREG------DCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKE 221
++ W+ ME + + + + EE + I ++ L+HL +
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAG--SVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 222 NLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPY-MAPERI----D 276
+ K+IHRDIK N+LL + +KL DFG+S QL ++ + PY MAPE I +
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 277 PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREF 336
P A+ YD +SD+WSLGIT E+A G P + + L + + P+L + +++
Sbjct: 206 PDAT---YDFKSDLWSLGITAIEMAEGAPPLCDMHPM-RALFLIPRNPAPRL---KSKKW 258
Query: 337 SPSFINFVNLCLTKDESKRPKYKELLKHPFI 367
S F +F+ CL K+ S+RP ++L+KHPFI
Sbjct: 259 SKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735590 TRAF2 and NCK interacting kinase isoform 7 [Homo
sapiens]
Length = 1276
Score = 132 bits (333), Expect = 4e-31
Identities = 88/271 (32%), Positives = 145/271 (53%), Gaps = 23/271 (8%)
Query: 108 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGA 167
+G G YG V K H +GQ+ A+K + T DE+E+ + +++++ + S I +YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 168 LFREG------DCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKE 221
++ W+ ME + + + + EE + I ++ L+HL +
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAG--SVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 222 NLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPY-MAPERI----D 276
+ K+IHRDIK N+LL + +KL DFG+S QL ++ + PY MAPE I +
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 277 PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREF 336
P A+ YD +SD+WSLGIT E+A G P + + L + + P+L + +++
Sbjct: 206 PDAT---YDFKSDLWSLGITAIEMAEGAPPLCDMHPM-RALFLIPRNPAPRL---KSKKW 258
Query: 337 SPSFINFVNLCLTKDESKRPKYKELLKHPFI 367
S F +F+ CL K+ S+RP ++L+KHPFI
Sbjct: 259 SKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735588 TRAF2 and NCK interacting kinase isoform 6 [Homo
sapiens]
Length = 1297
Score = 132 bits (333), Expect = 4e-31
Identities = 88/271 (32%), Positives = 145/271 (53%), Gaps = 23/271 (8%)
Query: 108 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGA 167
+G G YG V K H +GQ+ A+K + T DE+E+ + +++++ + S I +YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 168 LFREG------DCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKE 221
++ W+ ME + + + + EE + I ++ L+HL +
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAG--SVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 222 NLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPY-MAPERI----D 276
+ K+IHRDIK N+LL + +KL DFG+S QL ++ + PY MAPE I +
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 277 PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREF 336
P A+ YD +SD+WSLGIT E+A G P + + L + + P+L + +++
Sbjct: 206 PDAT---YDFKSDLWSLGITAIEMAEGAPPLCDMHPM-RALFLIPRNPAPRL---KSKKW 258
Query: 337 SPSFINFVNLCLTKDESKRPKYKELLKHPFI 367
S F +F+ CL K+ S+RP ++L+KHPFI
Sbjct: 259 SKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735586 TRAF2 and NCK interacting kinase isoform 5 [Homo
sapiens]
Length = 1305
Score = 132 bits (333), Expect = 4e-31
Identities = 88/271 (32%), Positives = 145/271 (53%), Gaps = 23/271 (8%)
Query: 108 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGA 167
+G G YG V K H +GQ+ A+K + T DE+E+ + +++++ + S I +YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 168 LFREG------DCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKE 221
++ W+ ME + + + + EE + I ++ L+HL +
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAG--SVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 222 NLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPY-MAPERI----D 276
+ K+IHRDIK N+LL + +KL DFG+S QL ++ + PY MAPE I +
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 277 PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREF 336
P A+ YD +SD+WSLGIT E+A G P + + L + + P+L + +++
Sbjct: 206 PDAT---YDFKSDLWSLGITAIEMAEGAPPLCDMHPM-RALFLIPRNPAPRL---KSKKW 258
Query: 337 SPSFINFVNLCLTKDESKRPKYKELLKHPFI 367
S F +F+ CL K+ S+RP ++L+KHPFI
Sbjct: 259 SKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735584 TRAF2 and NCK interacting kinase isoform 4 [Homo
sapiens]
Length = 1323
Score = 132 bits (333), Expect = 4e-31
Identities = 88/271 (32%), Positives = 145/271 (53%), Gaps = 23/271 (8%)
Query: 108 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGA 167
+G G YG V K H +GQ+ A+K + T DE+E+ + +++++ + S I +YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 168 LFREG------DCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKE 221
++ W+ ME + + + + EE + I ++ L+HL +
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAG--SVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 222 NLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPY-MAPERI----D 276
+ K+IHRDIK N+LL + +KL DFG+S QL ++ + PY MAPE I +
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 277 PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREF 336
P A+ YD +SD+WSLGIT E+A G P + + L + + P+L + +++
Sbjct: 206 PDAT---YDFKSDLWSLGITAIEMAEGAPPLCDMHPM-RALFLIPRNPAPRL---KSKKW 258
Query: 337 SPSFINFVNLCLTKDESKRPKYKELLKHPFI 367
S F +F+ CL K+ S+RP ++L+KHPFI
Sbjct: 259 SKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735582 TRAF2 and NCK interacting kinase isoform 3 [Homo
sapiens]
Length = 1331
Score = 132 bits (333), Expect = 4e-31
Identities = 88/271 (32%), Positives = 145/271 (53%), Gaps = 23/271 (8%)
Query: 108 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGA 167
+G G YG V K H +GQ+ A+K + T DE+E+ + +++++ + S I +YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 168 LFREG------DCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKE 221
++ W+ ME + + + + EE + I ++ L+HL +
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAG--SVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 222 NLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPY-MAPERI----D 276
+ K+IHRDIK N+LL + +KL DFG+S QL ++ + PY MAPE I +
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 277 PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREF 336
P A+ YD +SD+WSLGIT E+A G P + + L + + P+L + +++
Sbjct: 206 PDAT---YDFKSDLWSLGITAIEMAEGAPPLCDMHPM-RALFLIPRNPAPRL---KSKKW 258
Query: 337 SPSFINFVNLCLTKDESKRPKYKELLKHPFI 367
S F +F+ CL K+ S+RP ++L+KHPFI
Sbjct: 259 SKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|239735580 TRAF2 and NCK interacting kinase isoform 2 [Homo
sapiens]
Length = 1352
Score = 132 bits (333), Expect = 4e-31
Identities = 88/271 (32%), Positives = 145/271 (53%), Gaps = 23/271 (8%)
Query: 108 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGA 167
+G G YG V K H +GQ+ A+K + T DE+E+ + +++++ + S I +YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 168 LFREG------DCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKE 221
++ W+ ME + + + + EE + I ++ L+HL +
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAG--SVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 222 NLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPY-MAPERI----D 276
+ K+IHRDIK N+LL + +KL DFG+S QL ++ + PY MAPE I +
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 277 PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREF 336
P A+ YD +SD+WSLGIT E+A G P + + L + + P+L + +++
Sbjct: 206 PDAT---YDFKSDLWSLGITAIEMAEGAPPLCDMHPM-RALFLIPRNPAPRL---KSKKW 258
Query: 337 SPSFINFVNLCLTKDESKRPKYKELLKHPFI 367
S F +F+ CL K+ S+RP ++L+KHPFI
Sbjct: 259 SKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 132 bits (333), Expect = 4e-31
Identities = 88/271 (32%), Positives = 145/271 (53%), Gaps = 23/271 (8%)
Query: 108 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGA 167
+G G YG V K H +GQ+ A+K + T DE+E+ + +++++ + S I +YGA
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEE--IKQEINMLKKYSHHRNIATYYGA 88
Query: 168 LFREG------DCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKE 221
++ W+ ME + + + + EE + I ++ L+HL +
Sbjct: 89 FIKKNPPGMDDQLWLVMEFCGAG--SVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQ 146
Query: 222 NLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPY-MAPERI----D 276
+ K+IHRDIK N+LL + +KL DFG+S QL ++ + PY MAPE I +
Sbjct: 147 H-KVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDEN 205
Query: 277 PSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREF 336
P A+ YD +SD+WSLGIT E+A G P + + L + + P+L + +++
Sbjct: 206 PDAT---YDFKSDLWSLGITAIEMAEGAPPLCDMHPM-RALFLIPRNPAPRL---KSKKW 258
Query: 337 SPSFINFVNLCLTKDESKRPKYKELLKHPFI 367
S F +F+ CL K+ S+RP ++L+KHPFI
Sbjct: 259 SKKFQSFIESCLVKNHSQRPATEQLMKHPFI 289
>gi|134288915 myosin IIIB isoform 1 [Homo sapiens]
Length = 1314
Score = 132 bits (332), Expect = 6e-31
Identities = 96/295 (32%), Positives = 146/295 (49%), Gaps = 18/295 (6%)
Query: 108 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGA 167
IG+G YG V K+ +K G + AVK + D E+ + + +++ + P +V+FYG
Sbjct: 33 IGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEA--EYNILQFLPNHPNVVKFYGM 90
Query: 168 LFREGDC-----WICMELMSTSFDKFYKYVYSVL--DDVIPEEILGKITLATVKALNHLK 220
++ C W+ +EL + + V +L + E ++ I + L HL
Sbjct: 91 FYKADHCVGGQLWLVLELCNGG--SVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLH 148
Query: 221 ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDS-IAKTRDAGCRPYMAPERID-PS 278
N +IIHRD+K +NILL G +KL DFG+S QL + + + G +MAPE I
Sbjct: 149 NN-RIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQ 207
Query: 279 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSP 338
YD R DVWSLGIT EL G P + V L ++ + PP L + E ++
Sbjct: 208 QYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPV-KTLFKIPRNPPPTLLHPE--KWCE 264
Query: 339 SFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKIL-DQMPATP 392
F +F++ CL KD +RP LL HPFI + + + + K+L DQ P
Sbjct: 265 EFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNP 319
>gi|134288892 myosin IIIB isoform 2 [Homo sapiens]
Length = 1341
Score = 132 bits (332), Expect = 6e-31
Identities = 96/295 (32%), Positives = 146/295 (49%), Gaps = 18/295 (6%)
Query: 108 IGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGA 167
IG+G YG V K+ +K G + AVK + D E+ + + +++ + P +V+FYG
Sbjct: 33 IGKGTYGKVYKVTNKRDGSLAAVKILDPVSDMDEEIEA--EYNILQFLPNHPNVVKFYGM 90
Query: 168 LFREGDC-----WICMELMSTSFDKFYKYVYSVL--DDVIPEEILGKITLATVKALNHLK 220
++ C W+ +EL + + V +L + E ++ I + L HL
Sbjct: 91 FYKADHCVGGQLWLVLELCNGG--SVTELVKGLLRCGQRLDEAMISYILYGALLGLQHLH 148
Query: 221 ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDS-IAKTRDAGCRPYMAPERID-PS 278
N +IIHRD+K +NILL G +KL DFG+S QL + + + G +MAPE I
Sbjct: 149 NN-RIIHRDVKGNNILLTTEGGVKLVDFGVSAQLTSTRLRRNTSVGTPFWMAPEVIACEQ 207
Query: 279 ASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSP 338
YD R DVWSLGIT EL G P + V L ++ + PP L + E ++
Sbjct: 208 QYDSSYDARCDVWSLGITAIELGDGDPPLFDMHPV-KTLFKIPRNPPPTLLHPE--KWCE 264
Query: 339 SFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKIL-DQMPATP 392
F +F++ CL KD +RP LL HPFI + + + + K+L DQ P
Sbjct: 265 EFNHFISQCLIKDFERRPSVTHLLDHPFIKGVHGKVLFLQKQLAKVLQDQKHQNP 319
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,465,611
Number of Sequences: 37866
Number of extensions: 917102
Number of successful extensions: 14646
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 794
Number of HSP's successfully gapped in prelim test: 323
Number of HSP's that attempted gapping in prelim test: 8133
Number of HSP's gapped (non-prelim): 4584
length of query: 399
length of database: 18,247,518
effective HSP length: 104
effective length of query: 295
effective length of database: 14,309,454
effective search space: 4221288930
effective search space used: 4221288930
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.