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Search of human proteins with 4506423
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo
sapiens]
(454 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 929 0.0
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 809 0.0
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 659 0.0
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 648 0.0
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 648 0.0
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 641 0.0
gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens] 536 e-152
gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens] 445 e-125
gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo sapi... 243 2e-64
gi|189491771 thyroid hormone receptor, beta [Homo sapiens] 231 1e-60
gi|189491769 thyroid hormone receptor, beta [Homo sapiens] 231 1e-60
gi|40806162 thyroid hormone receptor, beta [Homo sapiens] 231 1e-60
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 221 1e-57
gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo sapi... 219 3e-57
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 214 1e-55
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 207 2e-53
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 207 2e-53
gi|11415052 retinoid X receptor, beta [Homo sapiens] 207 2e-53
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 206 5e-53
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 205 8e-53
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 205 8e-53
gi|45545429 estrogen-related receptor gamma isoform 2 [Homo sapi... 199 3e-51
gi|45545427 estrogen-related receptor gamma isoform 2 [Homo sapi... 199 3e-51
gi|45545433 estrogen-related receptor gamma isoform 1 [Homo sapi... 199 3e-51
gi|197209821 estrogen-related receptor gamma isoform 2 [Homo sap... 199 3e-51
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 197 1e-50
gi|238550159 estrogen-related receptor beta [Homo sapiens] 187 1e-47
gi|27894361 nuclear receptor subfamily 4, group A, member 3 isof... 183 2e-46
gi|27894357 nuclear receptor subfamily 4, group A, member 3 isof... 183 2e-46
gi|27894355 nuclear receptor subfamily 4, group A, member 3 isof... 183 2e-46
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 929 bits (2402), Expect = 0.0
Identities = 454/454 (100%), Positives = 454/454 (100%)
Query: 1 MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMAS 60
MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMAS
Sbjct: 1 MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMAS 60
Query: 61 LSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQK 120
LSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQK
Sbjct: 61 LSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQK 120
Query: 121 NMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY 180
NMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY
Sbjct: 121 NMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY 180
Query: 181 ELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIK 240
ELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIK
Sbjct: 181 ELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIK 240
Query: 241 IVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMH 300
IVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMH
Sbjct: 241 IVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMH 300
Query: 301 NAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEA 360
NAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEA
Sbjct: 301 NAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEA 360
Query: 361 LRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPE 420
LRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPE
Sbjct: 361 LRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPE 420
Query: 421 MFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA 454
MFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
Sbjct: 421 MFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA 454
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 809 bits (2090), Expect = 0.0
Identities = 409/453 (90%), Positives = 413/453 (91%), Gaps = 18/453 (3%)
Query: 2 ATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASL 61
A RL+ GA GPG+G A GS F GL P+ +
Sbjct: 9 APGPRRLY--GAAGPGAGL--------LRRATGGS--------CFAGLESFAWPQPASLQ 50
Query: 62 SVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKN 121
SVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKN
Sbjct: 51 SVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKN 110
Query: 122 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYE 181
MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYE
Sbjct: 111 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYE 170
Query: 182 LSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKI 241
LSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKI
Sbjct: 171 LSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKI 230
Query: 242 VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHN 301
VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHN
Sbjct: 231 VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHN 290
Query: 302 AGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEAL 361
AGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEAL
Sbjct: 291 AGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEAL 350
Query: 362 RLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEM 421
RLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEM
Sbjct: 351 RLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEM 410
Query: 422 FEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA 454
FEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA
Sbjct: 411 FEDDSSQPGPHPNASSEDEVPGGQGKGGLKSPA 443
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 659 bits (1700), Expect = 0.0
Identities = 317/382 (82%), Positives = 345/382 (90%)
Query: 42 LSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYH 101
L F GL Q + + S+ETQSTSSEE+VPS PSP PPPRVYKPCFVC DKSSGYH
Sbjct: 33 LKACFSGLTQTEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYH 92
Query: 102 YGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVR 161
YGVS+CEGCKGFFRRSIQKNM+YTCHRDKNC+INKVTRNRCQYCRLQKCFEVGMSKE+VR
Sbjct: 93 YGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVR 152
Query: 162 NDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQ 221
NDRNKKKKE ++ +SYE++ +L++L K+ KAHQETFPSLCQLGKYTTNSSADHRV+
Sbjct: 153 NDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVR 212
Query: 222 LDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTP 281
LDLGLWDKFSELATKCIIKIVEFAKRLPGFTGL+IADQITLLKAACLDIL+LRICTRYTP
Sbjct: 213 LDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTP 272
Query: 282 EQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDR 341
EQDTMTFSDGLTLNRTQMHNAGFGPLTDLVF FA QLLPLEMDDTETGLLSAICLICGDR
Sbjct: 273 EQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDR 332
Query: 342 MDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLK 401
DLEEP KVDKLQEPLLEAL++Y R+RRPS+P+MFP++LMKITDLR IS KGAER ITLK
Sbjct: 333 QDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLK 392
Query: 402 MEIPGPMPPLIREMLENPEMFE 423
MEIPG MPPLI+EMLEN E E
Sbjct: 393 MEIPGSMPPLIQEMLENSEGHE 414
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 648 bits (1671), Expect = 0.0
Identities = 330/457 (72%), Positives = 366/457 (80%), Gaps = 21/457 (4%)
Query: 1 MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMAS 60
MA+N G G +GYP + F FP L G P P Q LP S
Sbjct: 1 MASNSSSCPTPGG-GHLNGYPVPPYAFFFPPMLGGLSP-----PGALTTLQHQLPVSGYS 54
Query: 61 L----SVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRR 116
++ETQS+SSEE+VPS PSPPP PR+YKPCFVC DKSSGYHYGVS+CEGCKGFFRR
Sbjct: 55 TPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRR 114
Query: 117 SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGS 176
SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKKKEV +
Sbjct: 115 SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPEC 174
Query: 177 PDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATK 236
+SY L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TK
Sbjct: 175 SESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTK 234
Query: 237 CIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR 296
CIIK VEFAK+LPGFT L+IADQITLLKAACLDIL+LRICTRYTPEQDTMTFSDGLTLNR
Sbjct: 235 CIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR 294
Query: 297 TQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEP 356
TQMHNAGFGPLTDLVFAFA QLLPLEMDD ETGLLSAICLICGDR DLE+P++VD LQEP
Sbjct: 295 TQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEP 354
Query: 357 LLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREML 416
LLEAL++Y R+RRPS+P+MFP+MLMKITDLR IS KGAER ITLKMEIPG MPPLI+EML
Sbjct: 355 LLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEML 414
Query: 417 ENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 453
EN E + S QPG GG+ GGL P
Sbjct: 415 ENSEGLDTLSGQPG-----------GGGRDGGGLAPP 440
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 648 bits (1671), Expect = 0.0
Identities = 330/457 (72%), Positives = 366/457 (80%), Gaps = 21/457 (4%)
Query: 1 MATNKERLFAAGALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMAS 60
MA+N G G +GYP + F FP L G P P Q LP S
Sbjct: 1 MASNSSSCPTPGG-GHLNGYPVPPYAFFFPPMLGGLSP-----PGALTTLQHQLPVSGYS 54
Query: 61 L----SVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRR 116
++ETQS+SSEE+VPS PSPPP PR+YKPCFVC DKSSGYHYGVS+CEGCKGFFRR
Sbjct: 55 TPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRR 114
Query: 117 SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGS 176
SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKKKEV +
Sbjct: 115 SIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPEC 174
Query: 177 PDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATK 236
+SY L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TK
Sbjct: 175 SESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTK 234
Query: 237 CIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR 296
CIIK VEFAK+LPGFT L+IADQITLLKAACLDIL+LRICTRYTPEQDTMTFSDGLTLNR
Sbjct: 235 CIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNR 294
Query: 297 TQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEP 356
TQMHNAGFGPLTDLVFAFA QLLPLEMDD ETGLLSAICLICGDR DLE+P++VD LQEP
Sbjct: 295 TQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEP 354
Query: 357 LLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREML 416
LLEAL++Y R+RRPS+P+MFP+MLMKITDLR IS KGAER ITLKMEIPG MPPLI+EML
Sbjct: 355 LLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEML 414
Query: 417 ENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 453
EN E + S QPG GG+ GGL P
Sbjct: 415 ENSEGLDTLSGQPG-----------GGGRDGGGLAPP 440
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 641 bits (1653), Expect = 0.0
Identities = 312/392 (79%), Positives = 344/392 (87%), Gaps = 11/392 (2%)
Query: 62 SVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKN 121
S+ETQS+SSEE+VPS PSPPP PR+YKPCFVC DKSSGYHYGVS+CEGCKGFFRRSIQKN
Sbjct: 55 SIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKN 114
Query: 122 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYE 181
MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKKKEV + +SY
Sbjct: 115 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYT 174
Query: 182 LSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKI 241
L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S++ RV LD+ LWDKFSEL+TKCIIK
Sbjct: 175 LTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKT 234
Query: 242 VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHN 301
VEFAK+LPGFT L+IADQITLLKAACLDIL+LRICTRYTPEQDTMTFSDGLTLNRTQMHN
Sbjct: 235 VEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 294
Query: 302 AGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEAL 361
AGFGPLTDLVFAFA QLLPLEMDD ETGLLSAICLICGDR DLE+P++VD LQEPLLEAL
Sbjct: 295 AGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEAL 354
Query: 362 RLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEM 421
++Y R+RRPS+P+MFP+MLMKITDLR IS KGAER ITLKMEIPG MPPLI+EMLEN E
Sbjct: 355 KVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 414
Query: 422 FEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 453
+ S QPG GG+ GGL P
Sbjct: 415 LDTLSGQPG-----------GGGRDGGGLAPP 435
>gi|7706625 retinoic acid receptor, beta isoform 2 [Homo sapiens]
Length = 336
Score = 536 bits (1381), Expect = e-152
Identities = 258/302 (85%), Positives = 281/302 (93%)
Query: 122 MVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYE 181
M+YTCHRDKNC+INKVTRNRCQYCRLQKCFEVGMSKE+VRNDRNKKKKE ++ +SYE
Sbjct: 1 MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYE 60
Query: 182 LSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKI 241
++ +L++L K+ KAHQETFPSLCQLGKYTTNSSADHRV+LDLGLWDKFSELATKCIIKI
Sbjct: 61 MTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKI 120
Query: 242 VEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHN 301
VEFAKRLPGFTGL+IADQITLLKAACLDIL+LRICTRYTPEQDTMTFSDGLTLNRTQMHN
Sbjct: 121 VEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHN 180
Query: 302 AGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEAL 361
AGFGPLTDLVF FA QLLPLEMDDTETGLLSAICLICGDR DLEEP KVDKLQEPLLEAL
Sbjct: 181 AGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEAL 240
Query: 362 RLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEM 421
++Y R+RRPS+P+MFP++LMKITDLR IS KGAER ITLKMEIPG MPPLI+EMLEN E
Sbjct: 241 KIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG 300
Query: 422 FE 423
E
Sbjct: 301 HE 302
>gi|223718070 retinoic acid receptor, alpha isoform 4 [Homo sapiens]
Length = 365
Score = 445 bits (1144), Expect = e-125
Identities = 224/298 (75%), Positives = 250/298 (83%), Gaps = 11/298 (3%)
Query: 156 SKEAVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSS 215
S VRNDRNKKKKEV + +SY L+P++ ELI KV KAHQETFP+LCQLGKYTTN+S
Sbjct: 57 SPATVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNS 116
Query: 216 ADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRI 275
++ RV LD+ LWDKFSEL+TKCIIK VEFAK+LPGFT L+IADQITLLKAACLDIL+LRI
Sbjct: 117 SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRI 176
Query: 276 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAIC 335
CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFA QLLPLEMDD ETGLLSAIC
Sbjct: 177 CTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAIC 236
Query: 336 LICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAE 395
LICGDR DLE+P++VD LQEPLLEAL++Y R+RRPS+P+MFP+MLMKITDLR IS KGAE
Sbjct: 237 LICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAE 296
Query: 396 RAITLKMEIPGPMPPLIREMLENPEMFEDDSSQPGPHPNASSEDEVPGGQGKGGLKSP 453
R ITLKMEIPG MPPLI+EMLEN E + S QPG GG+ GGL P
Sbjct: 297 RVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPG-----------GGGRDGGGLAPP 343
>gi|40806160 thyroid hormone receptor, alpha isoform 1 [Homo
sapiens]
Length = 410
Score = 243 bits (621), Expect = 2e-64
Identities = 134/358 (37%), Positives = 202/358 (56%), Gaps = 26/358 (7%)
Query: 90 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 147
C VC DK++GYHY +CEGCKGFFRR+IQKN+ Y+C D C+I+K+TRN+CQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
Query: 148 QKCFEVGMSKEAVRND-------------RNKKKKEVKEEGSPDSYELSPQLEELITKVS 194
+KC VGM+ + V +D R +++KE E +P+ +LI +
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
Query: 195 KAHQETFPSLC---QLGKYTTNSSADHRV-------QLDLGLWDKFSELATKCIIKIVEF 244
+AH+ T Q K+ + + ++DL + +F+++ T I ++V+F
Sbjct: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
Query: 245 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 304
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
Query: 305 GPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLY 364
G ++D +F L +DDTE LL A+ L+ DR L +K++K QE L A Y
Sbjct: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
Query: 365 ARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM-PPLIREMLENPEM 421
R+ + P+ +P++LMK+TDLR I A R + +K+E P + PPL E+ E+ E+
Sbjct: 353 VNHRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFEDQEV 410
>gi|189491771 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 231 bits (588), Expect = 1e-60
Identities = 131/355 (36%), Positives = 197/355 (55%), Gaps = 26/355 (7%)
Query: 90 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 147
C VC DK++GYHY +CEGCKGFFRR+IQKN+ Y+C + C+I+KVTRN+CQ CR
Sbjct: 107 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRF 166
Query: 148 QKCFEVGMSKEAVRND-------------RNKKKKEVKEEGSPDSYELSPQLEELITKVS 194
+KC VGM+ + V +D R K+++E ++ E + + ELI V+
Sbjct: 167 KKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVT 226
Query: 195 KAHQETFPSLC---QLGKYTTNS-------SADHRVQLDLGLWDKFSELATKCIIKIVEF 244
+AH T Q K+ +A ++DL + F+++ T I ++V+F
Sbjct: 227 EAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDF 286
Query: 245 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 304
AK+LP F L DQI LLK C++I+ LR RY PE +T+T + + + R Q+ N G
Sbjct: 287 AKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGL 346
Query: 305 GPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLY 364
G ++D +F L +DDTE LL A+ L+ DR L E+++K Q+ L A Y
Sbjct: 347 GVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHY 406
Query: 365 ARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM-PPLIREMLEN 418
R+ + +P++LMK+TDLR I A R + +K+E P + PPL E+ E+
Sbjct: 407 INYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
>gi|189491769 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 231 bits (588), Expect = 1e-60
Identities = 131/355 (36%), Positives = 197/355 (55%), Gaps = 26/355 (7%)
Query: 90 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 147
C VC DK++GYHY +CEGCKGFFRR+IQKN+ Y+C + C+I+KVTRN+CQ CR
Sbjct: 107 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRF 166
Query: 148 QKCFEVGMSKEAVRND-------------RNKKKKEVKEEGSPDSYELSPQLEELITKVS 194
+KC VGM+ + V +D R K+++E ++ E + + ELI V+
Sbjct: 167 KKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVT 226
Query: 195 KAHQETFPSLC---QLGKYTTNS-------SADHRVQLDLGLWDKFSELATKCIIKIVEF 244
+AH T Q K+ +A ++DL + F+++ T I ++V+F
Sbjct: 227 EAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDF 286
Query: 245 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 304
AK+LP F L DQI LLK C++I+ LR RY PE +T+T + + + R Q+ N G
Sbjct: 287 AKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGL 346
Query: 305 GPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLY 364
G ++D +F L +DDTE LL A+ L+ DR L E+++K Q+ L A Y
Sbjct: 347 GVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHY 406
Query: 365 ARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM-PPLIREMLEN 418
R+ + +P++LMK+TDLR I A R + +K+E P + PPL E+ E+
Sbjct: 407 INYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
>gi|40806162 thyroid hormone receptor, beta [Homo sapiens]
Length = 461
Score = 231 bits (588), Expect = 1e-60
Identities = 131/355 (36%), Positives = 197/355 (55%), Gaps = 26/355 (7%)
Query: 90 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 147
C VC DK++GYHY +CEGCKGFFRR+IQKN+ Y+C + C+I+KVTRN+CQ CR
Sbjct: 107 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRF 166
Query: 148 QKCFEVGMSKEAVRND-------------RNKKKKEVKEEGSPDSYELSPQLEELITKVS 194
+KC VGM+ + V +D R K+++E ++ E + + ELI V+
Sbjct: 167 KKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVT 226
Query: 195 KAHQETFPSLC---QLGKYTTNS-------SADHRVQLDLGLWDKFSELATKCIIKIVEF 244
+AH T Q K+ +A ++DL + F+++ T I ++V+F
Sbjct: 227 EAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDF 286
Query: 245 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 304
AK+LP F L DQI LLK C++I+ LR RY PE +T+T + + + R Q+ N G
Sbjct: 287 AKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGL 346
Query: 305 GPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLY 364
G ++D +F L +DDTE LL A+ L+ DR L E+++K Q+ L A Y
Sbjct: 347 GVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHY 406
Query: 365 ARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM-PPLIREMLEN 418
R+ + +P++LMK+TDLR I A R + +K+E P + PPL E+ E+
Sbjct: 407 INYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED 461
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 221 bits (563), Expect = 1e-57
Identities = 133/416 (31%), Positives = 211/416 (50%), Gaps = 29/416 (6%)
Query: 17 GSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVP- 75
G+ G P+ + G P + +P L P + L+V +SSE++ P
Sbjct: 60 GTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPP----SSQLNVVNSVSSSEDIKPL 115
Query: 76 ---------SSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTC 126
+ PS P V C +C D+SSG HYGV SCEGCKGFF+R+I+K+++YTC
Sbjct: 116 PGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTC 175
Query: 127 HRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEG--SPDSYELSP 184
+K+C+I+K RNRCQYCR QKC +GM +EAV+ +R + ++ + E + +E P
Sbjct: 176 RDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMP 235
Query: 185 QLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVEF 244
+ ++ +A P G +S + V A K + +VE+
Sbjct: 236 -----VERILEAELAVEPKTESYGDMNMENSTNDPV-------TNICHAADKQLFTLVEW 283
Query: 245 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 304
AKR+P F+ L++ DQ+ LL+A ++L+ R QD + + GL ++R+ H+AG
Sbjct: 284 AKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGV 343
Query: 305 GPLTDLVFA-FAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRL 363
G + D V ++ ++MD +E G L AI L D L P +V+ L+E + L
Sbjct: 344 GSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEA 403
Query: 364 YARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENP 419
Y +++ P QP F ++L+++ LR I K E K+ P+ + EMLE P
Sbjct: 404 YTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETP 459
>gi|20127452 thyroid hormone receptor, alpha isoform 2 [Homo
sapiens]
Length = 490
Score = 219 bits (559), Expect = 3e-57
Identities = 122/331 (36%), Positives = 185/331 (55%), Gaps = 26/331 (7%)
Query: 90 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNM--VYTCHRDKNCIINKVTRNRCQYCRL 147
C VC DK++GYHY +CEGCKGFFRR+IQKN+ Y+C D C+I+K+TRN+CQ CR
Sbjct: 53 CVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRF 112
Query: 148 QKCFEVGMSKEAVRND-------------RNKKKKEVKEEGSPDSYELSPQLEELITKVS 194
+KC VGM+ + V +D R +++KE E +P+ +LI +
Sbjct: 113 KKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIAT 172
Query: 195 KAHQETFPSLC---QLGKYTTNSSADHRV-------QLDLGLWDKFSELATKCIIKIVEF 244
+AH+ T Q K+ + + ++DL + +F+++ T I ++V+F
Sbjct: 173 EAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDF 232
Query: 245 AKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGF 304
AK+LP F+ L DQI LLK C++I+ LR RY PE DT+T S + + R Q+ N G
Sbjct: 233 AKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGL 292
Query: 305 GPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLY 364
G ++D +F L +DDTE LL A+ L+ DR L +K++K QE L A Y
Sbjct: 293 GVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHY 352
Query: 365 ARRRRPSQPYMFPRMLMKITDLR-GISTKGA 394
R+ + P+ +P++LMK +++ I KGA
Sbjct: 353 VNHRKHNIPHFWPKLLMKEREVQSSILYKGA 383
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 214 bits (546), Expect = 1e-55
Identities = 141/442 (31%), Positives = 210/442 (47%), Gaps = 43/442 (9%)
Query: 12 GALGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQP----DLPKEMASLSVETQS 67
G++ S +P G PG L P LS G+G P P S+SV T
Sbjct: 26 GSMAAPSLHPSLGPGIGSPGQLHS--PISTLSSPINGMGPPFSVISSPMGPHSMSVPTTP 83
Query: 68 T------------------SSEEM-----------VPSSPSPPPPPRVYKPCFVCNDKSS 98
T SSE++ VP+ PS C +C D+SS
Sbjct: 84 TLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSS 143
Query: 99 GYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKE 158
G HYGV SCEGCKGFF+R+++K++ YTC +K+C+I+K RNRCQYCR QKC +GM +E
Sbjct: 144 GKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKRE 203
Query: 159 AVRNDRNKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADH 218
AV+ +R + K + E S E I + A + + + SS +
Sbjct: 204 AVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPND 263
Query: 219 RVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTR 278
V + A K + +VE+AKR+P F+ L + DQ+ LL+A ++L+ R
Sbjct: 264 PV-------TNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHR 316
Query: 279 YTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFA-FAGQLLPLEMDDTETGLLSAICLI 337
+D + + GL ++R H+AG G + D V ++ ++MD TE G L AI L
Sbjct: 317 SIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLF 376
Query: 338 CGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERA 397
D L P +V+ L+E + +L Y + + P QP F ++L+++ LR I K E
Sbjct: 377 NPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHL 436
Query: 398 ITLKMEIPGPMPPLIREMLENP 419
K+ P+ + EMLE P
Sbjct: 437 FFFKLIGDTPIDTFLMEMLEAP 458
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 207 bits (526), Expect = 2e-53
Identities = 119/367 (32%), Positives = 198/367 (53%), Gaps = 25/367 (6%)
Query: 72 EMVPSSPSPPPPPRVY--KPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRD 129
E+ P P P++ + C VC DK+SG+HY V SCEGCKGFFRRS+ K Y CH
Sbjct: 33 EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSG 92
Query: 130 KNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY--------- 180
+C ++ R +CQ CRL+KC + GM +E V ++ + K++K + ++
Sbjct: 93 GHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRAS 152
Query: 181 -------ELSPQ----LEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDK 229
+LSP+ +E+L+ + ++ +F ++ + + H + +
Sbjct: 153 SPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM-APDPHSREARQQRFAH 211
Query: 230 FSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFS 289
F+ELA + +IV+FAK+LPGF LS DQI LLK + +++++L RY P +++TF
Sbjct: 212 FTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFL 271
Query: 290 DGLTLNRTQMHNAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPE 348
+ NR AG + +F F+ + L+++D E LL AI + DR ++++
Sbjct: 272 KDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQL 331
Query: 349 KVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM 408
+V++LQ +EAL Y P MFPRMLMK+ LR +S+ +E+ L+++ +
Sbjct: 332 QVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKL 390
Query: 409 PPLIREM 415
PPL+ E+
Sbjct: 391 PPLLSEI 397
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 207 bits (526), Expect = 2e-53
Identities = 119/367 (32%), Positives = 198/367 (53%), Gaps = 25/367 (6%)
Query: 72 EMVPSSPSPPPPPRVY--KPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRD 129
E+ P P P++ + C VC DK+SG+HY V SCEGCKGFFRRS+ K Y CH
Sbjct: 78 EIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSG 137
Query: 130 KNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSY--------- 180
+C ++ R +CQ CRL+KC + GM +E V ++ + K++K + ++
Sbjct: 138 GHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRAS 197
Query: 181 -------ELSPQ----LEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDK 229
+LSP+ +E+L+ + ++ +F ++ + + H + +
Sbjct: 198 SPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM-APDPHSREARQQRFAH 256
Query: 230 FSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFS 289
F+ELA + +IV+FAK+LPGF LS DQI LLK + +++++L RY P +++TF
Sbjct: 257 FTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFL 316
Query: 290 DGLTLNRTQMHNAGFG-PLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPE 348
+ NR AG + +F F+ + L+++D E LL AI + DR ++++
Sbjct: 317 KDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQL 376
Query: 349 KVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPM 408
+V++LQ +EAL Y P MFPRMLMK+ LR +S+ +E+ L+++ +
Sbjct: 377 QVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQ-DKKL 435
Query: 409 PPLIREM 415
PPL+ E+
Sbjct: 436 PPLLSEI 442
>gi|11415052 retinoid X receptor, beta [Homo sapiens]
Length = 533
Score = 207 bits (526), Expect = 2e-53
Identities = 137/427 (32%), Positives = 211/427 (49%), Gaps = 31/427 (7%)
Query: 16 PGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVP 75
P G GA P P GSP F ++S S G P S V + +S +P
Sbjct: 111 PSLGGSGAPPPPPMPPPPLGSP-FPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLP 169
Query: 76 SSPSPPP---------------PPRVYKP------CFVCNDKSSGYHYGVSSCEGCKGFF 114
S PP PP P C +C D+SSG HYGV SCEGCKGFF
Sbjct: 170 GGGSGPPEDVKPPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFF 229
Query: 115 RRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNK-KKKEVKE 173
+R+I+K++ Y+C +K+C ++K RNRCQYCR QKC GM +EAV+ +R + K K+
Sbjct: 230 KRTIRKDLTYSCRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDG 289
Query: 174 EGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSEL 233
EG+ + E P ++ ++ Q++ + G + S+ + ++ +
Sbjct: 290 EGAGGAPEEMP-VDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNI------CQA 342
Query: 234 ATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLT 293
A K + +VE+AKR+P F+ L + DQ+ LL+A ++L+ R +D + + GL
Sbjct: 343 ADKQLFTLVEWAKRIPHFSSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLH 402
Query: 294 LNRTQMHNAGFGPLTDLVFA-FAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDK 352
++R H+AG G + D V ++ + MD TE G L AI L D L P +V+
Sbjct: 403 VHRNSAHSAGVGAIFDRVLTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEV 462
Query: 353 LQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLI 412
L+E + +L Y +++ P Q F ++L+++ LR I K E K+ P+ +
Sbjct: 463 LREKVYASLETYCKQKYPEQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFL 522
Query: 413 REMLENP 419
EMLE P
Sbjct: 523 MEMLEAP 529
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 206 bits (523), Expect = 5e-53
Identities = 138/458 (30%), Positives = 224/458 (48%), Gaps = 73/458 (15%)
Query: 16 PGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVP 75
PG+G P G P + P P + G PD+P + + S++ ++P
Sbjct: 14 PGNGPPQPGAPSSSPTVKEEGPE------PWPGGPDPDVP----GTDEASSACSTDWVIP 63
Query: 76 SSPSPP-------PPPRV--YKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMV--Y 124
P P P++ ++ C VC DK+SG+HY V SCEGCKGFFRRS+ + Y
Sbjct: 64 DPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRY 123
Query: 125 TCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSPDSYELS- 183
C C ++ R +CQ CRL+KC E GM ++ V ++ +KK+++++ +S S
Sbjct: 124 ACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQ 183
Query: 184 ----PQ--------------------------------------LEELITKVSKAHQETF 201
PQ +++L+ + ++ +F
Sbjct: 184 SPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSF 243
Query: 202 PSLCQLGKYTTNS---SADHRVQLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIAD 258
++ + + S D R Q + F+ELA + +IV+FAK++PGF L D
Sbjct: 244 SDQPKVTPWPLGADPQSRDARQQR----FAHFTELAIISVQEIVDFAKQVPGFLQLGRED 299
Query: 259 QITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFG-PLTDLVFAFAGQ 317
QI LLKA+ ++I++L RY E + +TF T ++ H AG + +F F+
Sbjct: 300 QIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRA 359
Query: 318 LLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFP 377
+ L +DD E LL AI + DR +++EP +V+ LQ+P +EAL Y R +RP FP
Sbjct: 360 MRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFP 419
Query: 378 RMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREM 415
RMLMK+ LR +S+ +E+ L+++ +PPL+ E+
Sbjct: 420 RMLMKLVSLRTLSSVHSEQVFALRLQ-DKKLPPLLSEI 456
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 205 bits (521), Expect = 8e-53
Identities = 146/418 (34%), Positives = 208/418 (49%), Gaps = 37/418 (8%)
Query: 1 MATNKERLFAAGA---LGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKE 57
+A + +LF + A LG G Y P AFPG SP E G G D P
Sbjct: 202 LAQSPLKLFPSQATHQLGEGESY---SMPTAFPGLAPTSPHLE-------GSGILDTP-- 249
Query: 58 MASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRS 117
ST + P C VC D +S HYGV +CEGCKGFF+R+
Sbjct: 250 -------VTSTKARSGAPGGSEGR--------CAVCGDNASCQHYGVRTCEGCKGFFKRT 294
Query: 118 IQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSP 177
+QKN Y C +K+C ++K RNRCQ+CR QKC VGM KE VR D K ++
Sbjct: 295 VQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPK 354
Query: 178 DSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSA-DHRVQLDLGLWDKFSELATK 236
+ SP L+T + +AH ++ PS +L H + D G +F +L +
Sbjct: 355 QPPDASP--ANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSG 412
Query: 237 CIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR 296
+ I ++A+++PGF LS ADQ LL++A L++ +LR+ R P + + F GL L+R
Sbjct: 413 SLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHR 472
Query: 297 TQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEP 356
Q GFG D + AF+ L L +D LSA+ LI DR L+EP +V++LQ
Sbjct: 473 LQCAR-GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNR 530
Query: 357 LLEALR--LYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLI 412
+ L+ + A P R+L K+ +LR + T+G +R LK+E P PP+I
Sbjct: 531 IASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPII 588
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 205 bits (521), Expect = 8e-53
Identities = 146/418 (34%), Positives = 208/418 (49%), Gaps = 37/418 (8%)
Query: 1 MATNKERLFAAGA---LGPGSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKE 57
+A + +LF + A LG G Y P AFPG SP E G G D P
Sbjct: 202 LAQSPLKLFPSQATHQLGEGESY---SMPTAFPGLAPTSPHLE-------GSGILDTP-- 249
Query: 58 MASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRS 117
ST + P C VC D +S HYGV +CEGCKGFF+R+
Sbjct: 250 -------VTSTKARSGAPGGSEGR--------CAVCGDNASCQHYGVRTCEGCKGFFKRT 294
Query: 118 IQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDRNKKKKEVKEEGSP 177
+QKN Y C +K+C ++K RNRCQ+CR QKC VGM KE VR D K ++
Sbjct: 295 VQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPK 354
Query: 178 DSYELSPQLEELITKVSKAHQETFPSLCQLGKYTTNSSA-DHRVQLDLGLWDKFSELATK 236
+ SP L+T + +AH ++ PS +L H + D G +F +L +
Sbjct: 355 QPPDASP--ANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSG 412
Query: 237 CIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNR 296
+ I ++A+++PGF LS ADQ LL++A L++ +LR+ R P + + F GL L+R
Sbjct: 413 SLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHR 472
Query: 297 TQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEP 356
Q GFG D + AF+ L L +D LSA+ LI DR L+EP +V++LQ
Sbjct: 473 LQCAR-GFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHGLQEPRRVEELQNR 530
Query: 357 LLEALR--LYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLI 412
+ L+ + A P R+L K+ +LR + T+G +R LK+E P PP+I
Sbjct: 531 IASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPII 588
>gi|45545429 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 199 bits (507), Expect = 3e-51
Identities = 134/389 (34%), Positives = 194/389 (49%), Gaps = 21/389 (5%)
Query: 36 SPPFEMLSPSFRGLGQP-DLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCN 94
SPP +P G G L + +S VE T E M+ S P + C VC
Sbjct: 58 SPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPK--------RLCLVCG 109
Query: 95 DKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVG 154
D +SGYHYGV+SCE CK FF+R+IQ N+ Y+C C I K R CQ CR KC +VG
Sbjct: 110 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 169
Query: 155 MSKEAVRNDR-----NKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGK 209
M KE VR DR K K+ + E SP L+PQL + K + + L
Sbjct: 170 MLKEGVRLDRVRGGRQKYKRRIDAENSP---YLNPQL---VQPAKKPYNKIVSHLLVAEP 223
Query: 210 YTTNSSADHRV-QLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACL 268
+ D V D+ +LA + ++ I+ +AK +PGF+ LS+ADQ++LL++A +
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283
Query: 269 DILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTET 328
+IL+L + R +D + ++D ++ Q AG L + + + ++++ E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEF 343
Query: 329 GLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRG 388
L AI L D M +E+ E V KLQ+ L EAL+ Y + P +MLM + LR
Sbjct: 344 VTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQ 403
Query: 389 ISTKGAERAITLKMEIPGPMPPLIREMLE 417
STK + +K+E PM L EMLE
Sbjct: 404 TSTKAVQHFYNIKLEGKVPMHKLFLEMLE 432
>gi|45545427 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 199 bits (507), Expect = 3e-51
Identities = 134/389 (34%), Positives = 194/389 (49%), Gaps = 21/389 (5%)
Query: 36 SPPFEMLSPSFRGLGQP-DLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCN 94
SPP +P G G L + +S VE T E M+ S P + C VC
Sbjct: 58 SPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPK--------RLCLVCG 109
Query: 95 DKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVG 154
D +SGYHYGV+SCE CK FF+R+IQ N+ Y+C C I K R CQ CR KC +VG
Sbjct: 110 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 169
Query: 155 MSKEAVRNDR-----NKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGK 209
M KE VR DR K K+ + E SP L+PQL + K + + L
Sbjct: 170 MLKEGVRLDRVRGGRQKYKRRIDAENSP---YLNPQL---VQPAKKPYNKIVSHLLVAEP 223
Query: 210 YTTNSSADHRV-QLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACL 268
+ D V D+ +LA + ++ I+ +AK +PGF+ LS+ADQ++LL++A +
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283
Query: 269 DILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTET 328
+IL+L + R +D + ++D ++ Q AG L + + + ++++ E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEF 343
Query: 329 GLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRG 388
L AI L D M +E+ E V KLQ+ L EAL+ Y + P +MLM + LR
Sbjct: 344 VTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQ 403
Query: 389 ISTKGAERAITLKMEIPGPMPPLIREMLE 417
STK + +K+E PM L EMLE
Sbjct: 404 TSTKAVQHFYNIKLEGKVPMHKLFLEMLE 432
>gi|45545433 estrogen-related receptor gamma isoform 1 [Homo
sapiens]
Length = 458
Score = 199 bits (507), Expect = 3e-51
Identities = 134/389 (34%), Positives = 194/389 (49%), Gaps = 21/389 (5%)
Query: 36 SPPFEMLSPSFRGLGQP-DLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCN 94
SPP +P G G L + +S VE T E M+ S P + C VC
Sbjct: 81 SPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPK--------RLCLVCG 132
Query: 95 DKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVG 154
D +SGYHYGV+SCE CK FF+R+IQ N+ Y+C C I K R CQ CR KC +VG
Sbjct: 133 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 192
Query: 155 MSKEAVRNDR-----NKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGK 209
M KE VR DR K K+ + E SP L+PQL + K + + L
Sbjct: 193 MLKEGVRLDRVRGGRQKYKRRIDAENSP---YLNPQL---VQPAKKPYNKIVSHLLVAEP 246
Query: 210 YTTNSSADHRV-QLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACL 268
+ D V D+ +LA + ++ I+ +AK +PGF+ LS+ADQ++LL++A +
Sbjct: 247 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 306
Query: 269 DILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTET 328
+IL+L + R +D + ++D ++ Q AG L + + + ++++ E
Sbjct: 307 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEF 366
Query: 329 GLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRG 388
L AI L D M +E+ E V KLQ+ L EAL+ Y + P +MLM + LR
Sbjct: 367 VTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQ 426
Query: 389 ISTKGAERAITLKMEIPGPMPPLIREMLE 417
STK + +K+E PM L EMLE
Sbjct: 427 TSTKAVQHFYNIKLEGKVPMHKLFLEMLE 455
>gi|197209821 estrogen-related receptor gamma isoform 2 [Homo
sapiens]
Length = 435
Score = 199 bits (507), Expect = 3e-51
Identities = 134/389 (34%), Positives = 194/389 (49%), Gaps = 21/389 (5%)
Query: 36 SPPFEMLSPSFRGLGQP-DLPKEMASLSVETQSTSSEEMVPSSPSPPPPPRVYKPCFVCN 94
SPP +P G G L + +S VE T E M+ S P + C VC
Sbjct: 58 SPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPK--------RLCLVCG 109
Query: 95 DKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVG 154
D +SGYHYGV+SCE CK FF+R+IQ N+ Y+C C I K R CQ CR KC +VG
Sbjct: 110 DIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVG 169
Query: 155 MSKEAVRNDR-----NKKKKEVKEEGSPDSYELSPQLEELITKVSKAHQETFPSLCQLGK 209
M KE VR DR K K+ + E SP L+PQL + K + + L
Sbjct: 170 MLKEGVRLDRVRGGRQKYKRRIDAENSP---YLNPQL---VQPAKKPYNKIVSHLLVAEP 223
Query: 210 YTTNSSADHRV-QLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACL 268
+ D V D+ +LA + ++ I+ +AK +PGF+ LS+ADQ++LL++A +
Sbjct: 224 EKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWM 283
Query: 269 DILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTET 328
+IL+L + R +D + ++D ++ Q AG L + + + ++++ E
Sbjct: 284 EILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEF 343
Query: 329 GLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRG 388
L AI L D M +E+ E V KLQ+ L EAL+ Y + P +MLM + LR
Sbjct: 344 VTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQ 403
Query: 389 ISTKGAERAITLKMEIPGPMPPLIREMLE 417
STK + +K+E PM L EMLE
Sbjct: 404 TSTKAVQHFYNIKLEGKVPMHKLFLEMLE 432
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 197 bits (502), Expect = 1e-50
Identities = 135/409 (33%), Positives = 216/409 (52%), Gaps = 35/409 (8%)
Query: 17 GSGYPGAGFPFAFPGALRGSPPFEMLSPSFRGLGQPDLPKEMASLSVETQSTSSEEMVPS 76
GS + G FA P +R P+ +G P L AS ++TQ VPS
Sbjct: 208 GSHHVVDGQTFAVPNPIR--------KPA--SMGFPGLQIGHASQLLDTQ-------VPS 250
Query: 77 SPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINK 136
PS P C VC D ++ HYGV +CEGCKGFF+R++QKN Y C +KNC ++K
Sbjct: 251 PPSRGSPSNEGL-CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDK 309
Query: 137 VTRNRCQYCRLQKCFEVGMSKEAVRND-------RNKKKKEVKEEGSPDSYELSPQLEEL 189
RNRCQYCR QKC VGM KE VR D R K + +E SP S +S L
Sbjct: 310 RRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQEPSPPSPPVS-----L 364
Query: 190 ITKVSKAHQETFPSLCQLGKYTTNSSADHRVQ-LDLGLWDKFSELATKCIIKIVEFAKRL 248
I+ + +AH ++ P++ L ++ D+++ D +F +L T + I +A+++
Sbjct: 365 ISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKI 424
Query: 249 PGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLT 308
PGF L ADQ L ++A L++ +LR+ R P + + F +G+ L+R Q GFG
Sbjct: 425 PGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVR-GFGEWI 483
Query: 309 DLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRLYARRR 368
D + F+ L + +D + ++A+ ++ +R L+EP++V++LQ ++ L+ +
Sbjct: 484 DSIVEFSSNLQNMNIDISAFSCIAALAMVT-ERHGLKEPKRVEELQNKIVNCLKDHVTFN 542
Query: 369 RP--SQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREM 415
++P ++L K+ +LR + T+G +R LK+E P P +I ++
Sbjct: 543 NGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKL 591
>gi|238550159 estrogen-related receptor beta [Homo sapiens]
Length = 508
Score = 187 bits (476), Expect = 1e-47
Identities = 136/439 (30%), Positives = 207/439 (47%), Gaps = 33/439 (7%)
Query: 17 GSGYPGAGFPFAFPGALRG--SPPFEMLSPSFRGLGQPDLP-----KEMASLSVETQSTS 69
GS GF A G SPP F G G P ++ AS +E +
Sbjct: 37 GSSDASGGFGLALGTHANGLDSPPM------FAGAGLGGTPCRKSYEDCASGIMEDSAIK 90
Query: 70 SEEMVPSSPSPPPPPRVYKPCFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRD 129
E M+ + P + C VC D +SGYHYGV+SCE CK FF+R+IQ N+ Y+C
Sbjct: 91 CEYMLNAIPK--------RLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPAT 142
Query: 130 KNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRND-----RNKKKKEVKEEGSPD-SYELS 183
C I K R CQ CR KC +VGM KE VR D R K K+ + E SP S ++S
Sbjct: 143 NECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQIS 202
Query: 184 PQLEELITKVSKAHQETFPSLCQLGKYTTNSSADHRVQLDLGLWDKFSELATKCIIKIVE 243
P ++ +TK+ P D + L +LA + ++ I+
Sbjct: 203 PPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTL------CDLADRELVVIIG 256
Query: 244 FAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDGLTLNRTQMHNAG 303
+AK +PGF+ LS+ DQ++LL++A ++IL+L I R P D + +++ ++ AG
Sbjct: 257 WAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAG 316
Query: 304 FGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVDKLQEPLLEALRL 363
L + + L+++ E L A+ L D M +E+ E V KLQ+ L EAL+
Sbjct: 317 LLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQD 376
Query: 364 YARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPGPMPPLIREMLENPEMFE 423
Y +R +P+ ++L+ + LR + K + ++K++ PM L EMLE E
Sbjct: 377 YELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKVGQE 436
Query: 424 DDSSQPGPHPNASSEDEVP 442
P +S + + P
Sbjct: 437 QLRGSPKDERMSSHDGKCP 455
>gi|27894361 nuclear receptor subfamily 4, group A, member 3 isoform
b [Homo sapiens]
Length = 637
Score = 183 bits (465), Expect = 2e-46
Identities = 122/369 (33%), Positives = 187/369 (50%), Gaps = 29/369 (7%)
Query: 65 TQSTSSEEMVPSSPSPPPPPRVYKP-----CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQ 119
T S ++ ++ SPS P PP C VC D ++ HYGV +CEGCKGFF+R++Q
Sbjct: 273 TPSPTASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQ 332
Query: 120 KNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDR---------NKKKKE 170
KN Y C +KNC ++K RNRCQYCR QKC VGM KE VR D +K K
Sbjct: 333 KNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSP 392
Query: 171 VKEEGSPDSYELSP--QLEELITKV--SKAHQETFPSLCQLGKYTTNSSADHRVQLDLGL 226
+++E S S P + L+ + S + C + + A+H Q
Sbjct: 393 LQQEPSQPSPPSPPICMMNALVRALTDSTPRDLDYSRYCPTDQAAAGTDAEHVQQ----- 447
Query: 227 WDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTM 286
F L T I +A+++PGFT L DQ L+++A L++ +LR+ R +D
Sbjct: 448 ---FYNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKF 504
Query: 287 TFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEE 346
F +GL L+R Q GFG D + F+ L L +D LSA+ +I +R L+E
Sbjct: 505 VFCNGLVLHRLQCLR-GFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKE 562
Query: 347 PEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPG 406
P++V++L + +L+ + + + +P ++L + +LR I T G +R LK+E
Sbjct: 563 PKRVEELCNKITSSLKDHQSKGQALEP-TESKVLGALVELRKICTLGLQRIFYLKLEDLV 621
Query: 407 PMPPLIREM 415
P +I ++
Sbjct: 622 SPPSIIDKL 630
>gi|27894357 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 183 bits (465), Expect = 2e-46
Identities = 122/369 (33%), Positives = 187/369 (50%), Gaps = 29/369 (7%)
Query: 65 TQSTSSEEMVPSSPSPPPPPRVYKP-----CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQ 119
T S ++ ++ SPS P PP C VC D ++ HYGV +CEGCKGFF+R++Q
Sbjct: 262 TPSPTASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQ 321
Query: 120 KNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDR---------NKKKKE 170
KN Y C +KNC ++K RNRCQYCR QKC VGM KE VR D +K K
Sbjct: 322 KNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSP 381
Query: 171 VKEEGSPDSYELSP--QLEELITKV--SKAHQETFPSLCQLGKYTTNSSADHRVQLDLGL 226
+++E S S P + L+ + S + C + + A+H Q
Sbjct: 382 LQQEPSQPSPPSPPICMMNALVRALTDSTPRDLDYSRYCPTDQAAAGTDAEHVQQ----- 436
Query: 227 WDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTM 286
F L T I +A+++PGFT L DQ L+++A L++ +LR+ R +D
Sbjct: 437 ---FYNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKF 493
Query: 287 TFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEE 346
F +GL L+R Q GFG D + F+ L L +D LSA+ +I +R L+E
Sbjct: 494 VFCNGLVLHRLQCLR-GFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKE 551
Query: 347 PEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPG 406
P++V++L + +L+ + + + +P ++L + +LR I T G +R LK+E
Sbjct: 552 PKRVEELCNKITSSLKDHQSKGQALEP-TESKVLGALVELRKICTLGLQRIFYLKLEDLV 610
Query: 407 PMPPLIREM 415
P +I ++
Sbjct: 611 SPPSIIDKL 619
>gi|27894355 nuclear receptor subfamily 4, group A, member 3 isoform
a [Homo sapiens]
Length = 626
Score = 183 bits (465), Expect = 2e-46
Identities = 122/369 (33%), Positives = 187/369 (50%), Gaps = 29/369 (7%)
Query: 65 TQSTSSEEMVPSSPSPPPPPRVYKP-----CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQ 119
T S ++ ++ SPS P PP C VC D ++ HYGV +CEGCKGFF+R++Q
Sbjct: 262 TPSPTASSLLGESPSLPSPPSRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQ 321
Query: 120 KNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKEAVRNDR---------NKKKKE 170
KN Y C +KNC ++K RNRCQYCR QKC VGM KE VR D +K K
Sbjct: 322 KNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSP 381
Query: 171 VKEEGSPDSYELSP--QLEELITKV--SKAHQETFPSLCQLGKYTTNSSADHRVQLDLGL 226
+++E S S P + L+ + S + C + + A+H Q
Sbjct: 382 LQQEPSQPSPPSPPICMMNALVRALTDSTPRDLDYSRYCPTDQAAAGTDAEHVQQ----- 436
Query: 227 WDKFSELATKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTM 286
F L T I +A+++PGFT L DQ L+++A L++ +LR+ R +D
Sbjct: 437 ---FYNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKF 493
Query: 287 TFSDGLTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEE 346
F +GL L+R Q GFG D + F+ L L +D LSA+ +I +R L+E
Sbjct: 494 VFCNGLVLHRLQCLR-GFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMIT-ERHGLKE 551
Query: 347 PEKVDKLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAERAITLKMEIPG 406
P++V++L + +L+ + + + +P ++L + +LR I T G +R LK+E
Sbjct: 552 PKRVEELCNKITSSLKDHQSKGQALEP-TESKVLGALVELRKICTLGLQRIFYLKLEDLV 610
Query: 407 PMPPLIREM 415
P +I ++
Sbjct: 611 SPPSIIDKL 619
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,188,197
Number of Sequences: 37866
Number of extensions: 1164378
Number of successful extensions: 9236
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 149
Number of HSP's successfully gapped in prelim test: 121
Number of HSP's that attempted gapping in prelim test: 8417
Number of HSP's gapped (non-prelim): 716
length of query: 454
length of database: 18,247,518
effective HSP length: 106
effective length of query: 348
effective length of database: 14,233,722
effective search space: 4953335256
effective search space used: 4953335256
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.