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Search of human proteins with 4505541
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505541 USO1 homolog, vesicle docking protein [Homo sapiens]
(962 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505541 USO1 homolog, vesicle docking protein [Homo sapiens] 1866 0.0
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 76 2e-13
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 76 2e-13
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 76 2e-13
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 76 2e-13
gi|82880656 coiled-coil domain containing 46 isoform a [Homo sap... 75 2e-13
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 75 4e-13
gi|38044112 restin isoform b [Homo sapiens] 73 1e-12
gi|4506751 restin isoform a [Homo sapiens] 73 1e-12
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 72 2e-12
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 71 4e-12
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 71 6e-12
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 71 6e-12
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 71 6e-12
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 69 2e-11
gi|71061468 centromere protein E [Homo sapiens] 69 3e-11
gi|41872583 Rho-associated, coiled-coil containing protein kinas... 67 8e-11
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 67 8e-11
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 67 8e-11
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 67 1e-10
gi|55770834 centromere protein F [Homo sapiens] 67 1e-10
gi|45439327 periplakin [Homo sapiens] 67 1e-10
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 66 1e-10
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 66 2e-10
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 66 2e-10
gi|19924131 RAD50 homolog isoform 2 [Homo sapiens] 66 2e-10
gi|19924129 RAD50 homolog isoform 1 [Homo sapiens] 66 2e-10
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 66 2e-10
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 65 2e-10
gi|14165274 golgi-associated microtubule-binding protein HOOK3 [... 65 4e-10
>gi|4505541 USO1 homolog, vesicle docking protein [Homo sapiens]
Length = 962
Score = 1866 bits (4834), Expect = 0.0
Identities = 962/962 (100%), Positives = 962/962 (100%)
Query: 1 MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQ 60
MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQ
Sbjct: 1 MNFLRGVMGGQSAGPQHTEAETIQKLCDRVASSTLLDDRRNAVRALKSLSKKYRLEVGIQ 60
Query: 61 AMEHLIHVLQTDRSDSEIIGYALDILYNIISNEEEEEVEENSTRQSEDLGSQFTEIFIKQ 120
AMEHLIHVLQTDRSDSEIIGYALDILYNIISNEEEEEVEENSTRQSEDLGSQFTEIFIKQ
Sbjct: 61 AMEHLIHVLQTDRSDSEIIGYALDILYNIISNEEEEEVEENSTRQSEDLGSQFTEIFIKQ 120
Query: 121 QENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSRE 180
QENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSRE
Sbjct: 121 QENVTLLLSLLEEFDFHVRWPGVKLLTSLLKQLGPQVQQIILVSPMGVSRLMDLLADSRE 180
Query: 181 VIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLL 240
VIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLL
Sbjct: 181 VIRNDGVLLLQALTRSNGAIQKIVAFENAFERLLDIISEEGNSDGGIVVEDCLILLQNLL 240
Query: 241 KNNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGAT 300
KNNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGAT
Sbjct: 241 KNNNSNQNFFKEGSYIQRMKPWFEVGDENSGWSAQKVTNLHLMLQLVRVLVSPTNPPGAT 300
Query: 301 SSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDYFASVNAPSNP 360
SSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDYFASVNAPSNP
Sbjct: 301 SSCQKAMFQCGLLQQLCTILMATGVPADILTETINTVSEVIRGCQVNQDYFASVNAPSNP 360
Query: 361 PRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNSVS 420
PRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNSVS
Sbjct: 361 PRPAIVVLLMSMVNERQPFVLRCAVLYCFQCFLYKNQKGQGEIVSTLLPSTIDATGNSVS 420
Query: 421 AGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTN 480
AGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTN
Sbjct: 421 AGQLLCGGLFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTN 480
Query: 481 ILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGL 540
ILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGL
Sbjct: 481 ILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGL 540
Query: 541 CALLLGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPN 600
CALLLGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPN
Sbjct: 541 CALLLGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPN 600
Query: 601 FPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIR 660
FPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIR
Sbjct: 601 FPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIR 660
Query: 661 EQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSE 720
EQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSE
Sbjct: 661 EQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSE 720
Query: 721 GAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVS 780
GAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVS
Sbjct: 721 GAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVS 780
Query: 781 ARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIA 840
ARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIA
Sbjct: 781 ARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIA 840
Query: 841 TKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEIT 900
TKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEIT
Sbjct: 841 TKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEIT 900
Query: 901 DSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLD 960
DSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLD
Sbjct: 901 DSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLD 960
Query: 961 HI 962
HI
Sbjct: 961 HI 962
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 75.9 bits (185), Expect = 2e-13
Identities = 100/477 (20%), Positives = 209/477 (43%), Gaps = 51/477 (10%)
Query: 526 IAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRIGK-----ENFIEK 580
+ NL EEE+ + L L ++ + +EK +Q +EK K +F E+
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 581 LGFIS------KHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVIT--------- 625
+ + K +L + + + + + K ++ELEG I+
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 626 KAIYKSSEEDKKE-----EEVKKTLEQH-DNIVTHYK-NMIREQDLQL--EELRQQVSTL 676
+A +E+ K++ E +K LE D+ T + REQ++ + + L ++ +
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 677 KCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLR 736
+ Q ++++ Q V ++ + +Q+ K L K+ Q E A + G + +G+ +
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK--ENADLAG-ELRVLGQAK 1247
Query: 737 EEIEELKRNQEL----LQS----------QLTEKDSMIENMKSSQTSGTNE-QSSAIVSA 781
+E+E K+ E LQS +L +K ++N S T NE + AI A
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307
Query: 782 RDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIAT 841
+D VA L +L + L ++ + + T+ ++L ++ + ++ + E + +
Sbjct: 1308 KD---VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 842 KTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITD 901
+ + +LS ++ ++ + ++AL E + ++++++ DKLE
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 902 SKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKD 958
++E DDL+V L +Q Q + +L+ K + + EE + S DE D +E ++
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI-SSKYADERDRAEAEARE 1480
Score = 68.2 bits (165), Expect = 4e-11
Identities = 99/454 (21%), Positives = 185/454 (40%), Gaps = 98/454 (21%)
Query: 605 EYMIFDHEFTKLVKE---LEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIRE 661
E ++ D + KL KE LE I+ +EE++K + + K +H+++++ + +++
Sbjct: 986 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1045
Query: 662 QDL---------------------QLEELRQQVSTLKCQ----NEQLQTAVTQQVSQIQQ 696
++ Q+ +L+ Q++ LK Q E+LQ A+ + +I Q
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1105
Query: 697 HKDQYNLLKIQLGKDNQHQGSY-SEGAQMNGIQP------EEIGRLREEIEE-------- 741
+ ++ G + Q SE A N + EE+ L+ E+E+
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 742 ----LKRNQEL------LQSQLTEKDSMIENMKSSQTSGTNEQSSAI-----VSARDSEQ 786
KR QE+ L + ++ ++ M+ E + + A +
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 787 VAELKQELATLKSQLN-----SQSVE--ITKLQTEKQELLQK--------TEAFAKSVEV 831
L++E A L +L Q VE KL+ + QEL K E K ++
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 832 QGETETII---------ATKTTDVEGRLSALLQETKELKNE-----------IKALSEER 871
Q E E++ A K LS+ LQ+T+EL E ++ L EER
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 872 TAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLG 931
++++QLD L+ L ++++DSKK+ D + ++ + ++++L
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 932 HPVEEE----DELESGDQEDEDDESEDPGKDLDH 961
EE+ D+LE + E +D DLD+
Sbjct: 1406 QQYEEKAAAYDKLEK-TKNRLQQELDDLVVDLDN 1438
Score = 65.5 bits (158), Expect = 2e-10
Identities = 78/334 (23%), Positives = 147/334 (44%), Gaps = 62/334 (18%)
Query: 628 IYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLE-----ELRQQVSTLKCQNEQ 682
+ K+ E +K E K LEQ + +T KN+++EQ LQ E E + L + ++
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ-LQAETELYAEAEEMRVRLAAKKQE 919
Query: 683 LQTAVTQQVSQIQQHKDQYNLLKIQLGK------DNQHQGSYSEGA----QMNGIQPE-E 731
L+ + + +++++ +D+ L+ + K D + Q E A Q+ + E +
Sbjct: 920 LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 979
Query: 732 IGRLREEI-------EELKRNQELLQSQLT----------EKDSMIENMKSSQTSGTNEQ 774
I +L +EI +L + ++LL+ +++ EK + +K+ S +E
Sbjct: 980 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039
Query: 775 SSAIVSARDS-------------------EQVAELKQELATLKSQLNSQSVEI-TKLQTE 814
+ S EQ+A+L+ ++A LK QL + E+ L
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099
Query: 815 KQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAI 874
E+ QK A K E++G I+ D++ +A + K+ ++ L EE A+
Sbjct: 1100 DDEIAQKNNALKKIRELEGH----ISDLQEDLDSERAARNKAEKQKRD----LGEELEAL 1151
Query: 875 KEQLDSSNSTIAILQTEKDKLELEITDSKKEQDD 908
K +L+ + + A Q + K E E+T KK D+
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Score = 55.1 bits (131), Expect = 3e-07
Identities = 68/310 (21%), Positives = 138/310 (44%), Gaps = 26/310 (8%)
Query: 660 REQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYS 719
+E +LQ + RQQ K +NE + + Q+ SQ+ + K NLL+ QL + +
Sbjct: 857 KEDELQKTKERQQ----KAENELKE--LEQKHSQLTEEK---NLLQEQLQAETELYAEAE 907
Query: 720 EGAQMNGIQPEEIGRLREEI-----EELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQ 774
E + +E+ + E+ EE R Q+L + M++ + + Q
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 967
Query: 775 SSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQEL---LQKTEAFAKSV-E 830
+ ++ +L+ E+ + Q N S E L+ +L L + E AK++ +
Sbjct: 968 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027
Query: 831 VQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQT 890
++ + E++I +++E RL + +EL+ + L + + EQ+ + IA L+
Sbjct: 1028 LKNKHESMI----SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 891 EKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDD 950
+ K E E+ + DD + + +KI L+ + DL +E+ + E + +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL----QEDLDSERAARNKAEK 1139
Query: 951 ESEDPGKDLD 960
+ D G++L+
Sbjct: 1140 QKRDLGEELE 1149
Score = 52.4 bits (124), Expect = 2e-06
Identities = 89/450 (19%), Positives = 199/450 (44%), Gaps = 44/450 (9%)
Query: 525 QIAENLGEEEQLVQGLCALLLGISIYFND--NSLESYMKEK------LKQLIEKRIGKEN 576
Q+ NL ++++ L A IS + D + E+ +EK L + +E+ + +
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 577 FIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKA---IYKSSE 633
+E+ + K E+ S K HE K + LE + + + + +
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNV-------HELEKSKRALETQMEEMKTQLEELED 1553
Query: 634 EDKKEEEVKKTLEQHDNIVT-HYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVS 692
E + E+ K LE + + ++ ++ +D Q EE R+Q L+ Q + +T + +
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ---LQRQLHEYETELEDERK 1610
Query: 693 Q-----IQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQE 747
Q + K + +L ++L D+ +G Q+ +Q + + + E+E+ + +++
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ-MKDFQRELEDARASRD 1669
Query: 748 LLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSE-QVAELKQELATLKSQLNSQSV 806
+ + E + +++++ + ++A + + ++ + EL +ELA+ S N+
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1729
Query: 807 E-------ITKLQTEKQELLQKTEAFA----KSVEVQGETETIIATKTTDVEGRLSALLQ 855
E I +L+ E +E EA + K+ + + +AT+ + + SA Q
Sbjct: 1730 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1789
Query: 856 ETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLAD 915
++ K L E A+K + STIA L+ + +LE ++ +E+ L
Sbjct: 1790 LERQNKELRSKLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1846
Query: 916 QDQKILSLKNKLKDLGHPVEE-EDELESGD 944
+D+K+ + +++D E+ +++ E G+
Sbjct: 1847 KDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876
Score = 51.2 bits (121), Expect = 5e-06
Identities = 62/272 (22%), Positives = 115/272 (42%), Gaps = 24/272 (8%)
Query: 687 VTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIE---ELK 743
VT+Q ++Q +D+ K + + + E Q + EE L+E+++ EL
Sbjct: 847 VTRQEEEMQAKEDELQKTK---ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 744 RNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELK---QELATLKSQ 800
E ++ +L K +E + + E+ R + AE K Q++ L+ Q
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEED-----RGQQLQAERKKMAQQMLDLEEQ 958
Query: 801 LNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKEL 860
L + KLQ EK K + + V + ++ + +E R+S L E
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 861 KNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQD--DLLVLLADQDQ 918
+ + K L++ + K + S + + + EK + ELE K E D D +AD
Sbjct: 1019 EEKAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 919 KILSLKNKLKDLGHPVEEEDELESGDQEDEDD 950
+I LK +L ++E+EL++ +D+
Sbjct: 1077 QIAELKMQL------AKKEEELQAALARLDDE 1102
Score = 51.2 bits (121), Expect = 5e-06
Identities = 64/354 (18%), Positives = 145/354 (40%), Gaps = 34/354 (9%)
Query: 618 KELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLK 677
K+LE + + K S+ ++ E+ + + N V M+ E + + +L + V++L
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 678 CQNEQLQTAVTQQVSQ-------IQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPE 730
Q + Q + ++ Q ++Q +++ N L+ QL ++ + + + IQ
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374
Query: 731 E-----------IGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIV 779
+ + L E + ++ E L Q EK + + ++ ++ E +V
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 780 SARDSEQVA--------ELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEV 831
+ Q+ + Q LA K+ + + E + + E +E K + A+++E
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 832 QGE-------TETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNST 884
E T ++ + D+ + + EL+ +AL + +K QL+
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 885 IAILQTEKDKLELEITDSKKE-QDDLLVLLADQDQKILSLKNKLKDLGHPVEEE 937
+ + K +LE+ + K + + DL ++K L+ +L + +E+E
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608
Score = 39.7 bits (91), Expect = 0.014
Identities = 51/288 (17%), Positives = 119/288 (41%), Gaps = 26/288 (9%)
Query: 561 KEKLKQLIEKRIGKENFIEKL--GFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVK 618
+E +KQL + + ++F +L S+ E+++ A + + + + + +L +
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK------KAKSLEADLMQLQE 1694
Query: 619 ELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNI----------VTHYKNMIREQDLQLEE 668
+L E+++ EE+ +L + + + + + E+ +E
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 669 LRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQ 728
+ +V Q EQL + + S Q+++ L+ Q K+ + + EGA + +
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ-NKELRSKLHEMEGAVKSKFK 1813
Query: 729 PE------EIGRLREEIEELKRNQELLQSQLTEKDSMI-ENMKSSQTSGTNEQSSAIVSA 781
+I +L E++E+ R ++ L +KD + E + + + +
Sbjct: 1814 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1873
Query: 782 RDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSV 829
+ + +V +LK++L + + + KLQ E E + EA + V
Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921
Score = 30.4 bits (67), Expect = 8.3
Identities = 18/88 (20%), Positives = 38/88 (43%), Gaps = 7/88 (7%)
Query: 633 EEDKKEEEVKKTLEQHDNIVTHYKNM-------IREQDLQLEELRQQVSTLKCQNEQLQT 685
++DKK +E+ +E + YK +++ QLEE ++ + +LQ
Sbjct: 1846 QKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 1905
Query: 686 AVTQQVSQIQQHKDQYNLLKIQLGKDNQ 713
+ + + + N LK +L + N+
Sbjct: 1906 ELDEATESNEAMGREVNALKSKLRRGNE 1933
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 75.9 bits (185), Expect = 2e-13
Identities = 100/477 (20%), Positives = 209/477 (43%), Gaps = 51/477 (10%)
Query: 526 IAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRIGK-----ENFIEK 580
+ NL EEE+ + L L ++ + +EK +Q +EK K +F E+
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 581 LGFIS------KHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVIT--------- 625
+ + K +L + + + + + K ++ELEG I+
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 626 KAIYKSSEEDKKE-----EEVKKTLEQH-DNIVTHYK-NMIREQDLQL--EELRQQVSTL 676
+A +E+ K++ E +K LE D+ T + REQ++ + + L ++ +
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 677 KCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLR 736
+ Q ++++ Q V ++ + +Q+ K L K+ Q E A + G + +G+ +
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK--ENADLAG-ELRVLGQAK 1254
Query: 737 EEIEELKRNQEL----LQS----------QLTEKDSMIENMKSSQTSGTNE-QSSAIVSA 781
+E+E K+ E LQS +L +K ++N S T NE + AI A
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314
Query: 782 RDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIAT 841
+D VA L +L + L ++ + + T+ ++L ++ + ++ + E + +
Sbjct: 1315 KD---VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 842 KTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITD 901
+ + +LS ++ ++ + ++AL E + ++++++ DKLE
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 902 SKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKD 958
++E DDL+V L +Q Q + +L+ K + + EE + S DE D +E ++
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI-SSKYADERDRAEAEARE 1487
Score = 68.2 bits (165), Expect = 4e-11
Identities = 99/454 (21%), Positives = 185/454 (40%), Gaps = 98/454 (21%)
Query: 605 EYMIFDHEFTKLVKE---LEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIRE 661
E ++ D + KL KE LE I+ +EE++K + + K +H+++++ + +++
Sbjct: 993 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1052
Query: 662 QDL---------------------QLEELRQQVSTLKCQ----NEQLQTAVTQQVSQIQQ 696
++ Q+ +L+ Q++ LK Q E+LQ A+ + +I Q
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1112
Query: 697 HKDQYNLLKIQLGKDNQHQGSY-SEGAQMNGIQP------EEIGRLREEIEE-------- 741
+ ++ G + Q SE A N + EE+ L+ E+E+
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 742 ----LKRNQEL------LQSQLTEKDSMIENMKSSQTSGTNEQSSAI-----VSARDSEQ 786
KR QE+ L + ++ ++ M+ E + + A +
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 787 VAELKQELATLKSQLN-----SQSVE--ITKLQTEKQELLQK--------TEAFAKSVEV 831
L++E A L +L Q VE KL+ + QEL K E K ++
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 832 QGETETII---------ATKTTDVEGRLSALLQETKELKNE-----------IKALSEER 871
Q E E++ A K LS+ LQ+T+EL E ++ L EER
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 872 TAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLG 931
++++QLD L+ L ++++DSKK+ D + ++ + ++++L
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 932 HPVEEE----DELESGDQEDEDDESEDPGKDLDH 961
EE+ D+LE + E +D DLD+
Sbjct: 1413 QQYEEKAAAYDKLEK-TKNRLQQELDDLVVDLDN 1445
Score = 65.5 bits (158), Expect = 2e-10
Identities = 78/334 (23%), Positives = 147/334 (44%), Gaps = 62/334 (18%)
Query: 628 IYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLE-----ELRQQVSTLKCQNEQ 682
+ K+ E +K E K LEQ + +T KN+++EQ LQ E E + L + ++
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ-LQAETELYAEAEEMRVRLAAKKQE 926
Query: 683 LQTAVTQQVSQIQQHKDQYNLLKIQLGK------DNQHQGSYSEGA----QMNGIQPE-E 731
L+ + + +++++ +D+ L+ + K D + Q E A Q+ + E +
Sbjct: 927 LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 986
Query: 732 IGRLREEI-------EELKRNQELLQSQLT----------EKDSMIENMKSSQTSGTNEQ 774
I +L +EI +L + ++LL+ +++ EK + +K+ S +E
Sbjct: 987 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046
Query: 775 SSAIVSARDS-------------------EQVAELKQELATLKSQLNSQSVEI-TKLQTE 814
+ S EQ+A+L+ ++A LK QL + E+ L
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106
Query: 815 KQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAI 874
E+ QK A K E++G I+ D++ +A + K+ ++ L EE A+
Sbjct: 1107 DDEIAQKNNALKKIRELEGH----ISDLQEDLDSERAARNKAEKQKRD----LGEELEAL 1158
Query: 875 KEQLDSSNSTIAILQTEKDKLELEITDSKKEQDD 908
K +L+ + + A Q + K E E+T KK D+
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Score = 55.1 bits (131), Expect = 3e-07
Identities = 68/310 (21%), Positives = 138/310 (44%), Gaps = 26/310 (8%)
Query: 660 REQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYS 719
+E +LQ + RQQ K +NE + + Q+ SQ+ + K NLL+ QL + +
Sbjct: 864 KEDELQKTKERQQ----KAENELKE--LEQKHSQLTEEK---NLLQEQLQAETELYAEAE 914
Query: 720 EGAQMNGIQPEEIGRLREEI-----EELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQ 774
E + +E+ + E+ EE R Q+L + M++ + + Q
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 974
Query: 775 SSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQEL---LQKTEAFAKSV-E 830
+ ++ +L+ E+ + Q N S E L+ +L L + E AK++ +
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034
Query: 831 VQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQT 890
++ + E++I +++E RL + +EL+ + L + + EQ+ + IA L+
Sbjct: 1035 LKNKHESMI----SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 891 EKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDD 950
+ K E E+ + DD + + +KI L+ + DL +E+ + E + +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL----QEDLDSERAARNKAEK 1146
Query: 951 ESEDPGKDLD 960
+ D G++L+
Sbjct: 1147 QKRDLGEELE 1156
Score = 52.4 bits (124), Expect = 2e-06
Identities = 89/450 (19%), Positives = 199/450 (44%), Gaps = 44/450 (9%)
Query: 525 QIAENLGEEEQLVQGLCALLLGISIYFND--NSLESYMKEK------LKQLIEKRIGKEN 576
Q+ NL ++++ L A IS + D + E+ +EK L + +E+ + +
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507
Query: 577 FIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKA---IYKSSE 633
+E+ + K E+ S K HE K + LE + + + + +
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNV-------HELEKSKRALETQMEEMKTQLEELED 1560
Query: 634 EDKKEEEVKKTLEQHDNIVT-HYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVS 692
E + E+ K LE + + ++ ++ +D Q EE R+Q L+ Q + +T + +
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ---LQRQLHEYETELEDERK 1617
Query: 693 Q-----IQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQE 747
Q + K + +L ++L D+ +G Q+ +Q + + + E+E+ + +++
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ-MKDFQRELEDARASRD 1676
Query: 748 LLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSE-QVAELKQELATLKSQLNSQSV 806
+ + E + +++++ + ++A + + ++ + EL +ELA+ S N+
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1736
Query: 807 E-------ITKLQTEKQELLQKTEAFA----KSVEVQGETETIIATKTTDVEGRLSALLQ 855
E I +L+ E +E EA + K+ + + +AT+ + + SA Q
Sbjct: 1737 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1796
Query: 856 ETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLAD 915
++ K L E A+K + STIA L+ + +LE ++ +E+ L
Sbjct: 1797 LERQNKELRSKLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1853
Query: 916 QDQKILSLKNKLKDLGHPVEE-EDELESGD 944
+D+K+ + +++D E+ +++ E G+
Sbjct: 1854 KDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883
Score = 51.2 bits (121), Expect = 5e-06
Identities = 62/272 (22%), Positives = 115/272 (42%), Gaps = 24/272 (8%)
Query: 687 VTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIE---ELK 743
VT+Q ++Q +D+ K + + + E Q + EE L+E+++ EL
Sbjct: 854 VTRQEEEMQAKEDELQKTK---ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 744 RNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELK---QELATLKSQ 800
E ++ +L K +E + + E+ R + AE K Q++ L+ Q
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEED-----RGQQLQAERKKMAQQMLDLEEQ 965
Query: 801 LNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKEL 860
L + KLQ EK K + + V + ++ + +E R+S L E
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 861 KNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQD--DLLVLLADQDQ 918
+ + K L++ + K + S + + + EK + ELE K E D D +AD
Sbjct: 1026 EEKAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 919 KILSLKNKLKDLGHPVEEEDELESGDQEDEDD 950
+I LK +L ++E+EL++ +D+
Sbjct: 1084 QIAELKMQL------AKKEEELQAALARLDDE 1109
Score = 51.2 bits (121), Expect = 5e-06
Identities = 64/354 (18%), Positives = 145/354 (40%), Gaps = 34/354 (9%)
Query: 618 KELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLK 677
K+LE + + K S+ ++ E+ + + N V M+ E + + +L + V++L
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 678 CQNEQLQTAVTQQVSQ-------IQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPE 730
Q + Q + ++ Q ++Q +++ N L+ QL ++ + + + IQ
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381
Query: 731 E-----------IGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIV 779
+ + L E + ++ E L Q EK + + ++ ++ E +V
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 780 SARDSEQVA--------ELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEV 831
+ Q+ + Q LA K+ + + E + + E +E K + A+++E
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 832 QGE-------TETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNST 884
E T ++ + D+ + + EL+ +AL + +K QL+
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 885 IAILQTEKDKLELEITDSKKE-QDDLLVLLADQDQKILSLKNKLKDLGHPVEEE 937
+ + K +LE+ + K + + DL ++K L+ +L + +E+E
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615
Score = 39.7 bits (91), Expect = 0.014
Identities = 51/288 (17%), Positives = 119/288 (41%), Gaps = 26/288 (9%)
Query: 561 KEKLKQLIEKRIGKENFIEKL--GFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVK 618
+E +KQL + + ++F +L S+ E+++ A + + + + + +L +
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK------KAKSLEADLMQLQE 1701
Query: 619 ELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNI----------VTHYKNMIREQDLQLEE 668
+L E+++ EE+ +L + + + + + E+ +E
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 669 LRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQ 728
+ +V Q EQL + + S Q+++ L+ Q K+ + + EGA + +
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ-NKELRSKLHEMEGAVKSKFK 1820
Query: 729 PE------EIGRLREEIEELKRNQELLQSQLTEKDSMI-ENMKSSQTSGTNEQSSAIVSA 781
+I +L E++E+ R ++ L +KD + E + + + +
Sbjct: 1821 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880
Query: 782 RDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSV 829
+ + +V +LK++L + + + KLQ E E + EA + V
Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928
Score = 30.4 bits (67), Expect = 8.3
Identities = 18/88 (20%), Positives = 38/88 (43%), Gaps = 7/88 (7%)
Query: 633 EEDKKEEEVKKTLEQHDNIVTHYKNM-------IREQDLQLEELRQQVSTLKCQNEQLQT 685
++DKK +E+ +E + YK +++ QLEE ++ + +LQ
Sbjct: 1853 QKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQR 1912
Query: 686 AVTQQVSQIQQHKDQYNLLKIQLGKDNQ 713
+ + + + N LK +L + N+
Sbjct: 1913 ELDEATESNEAMGREVNALKSKLRRGNE 1940
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 75.9 bits (185), Expect = 2e-13
Identities = 100/477 (20%), Positives = 209/477 (43%), Gaps = 51/477 (10%)
Query: 526 IAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRIGK-----ENFIEK 580
+ NL EEE+ + L L ++ + +EK +Q +EK K +F E+
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077
Query: 581 LGFIS------KHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVIT--------- 625
+ + K +L + + + + + K ++ELEG I+
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 626 KAIYKSSEEDKKE-----EEVKKTLEQH-DNIVTHYK-NMIREQDLQL--EELRQQVSTL 676
+A +E+ K++ E +K LE D+ T + REQ++ + + L ++ +
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197
Query: 677 KCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLR 736
+ Q ++++ Q V ++ + +Q+ K L K+ Q E A + G + +G+ +
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK--ENADLAG-ELRVLGQAK 1254
Query: 737 EEIEELKRNQEL----LQS----------QLTEKDSMIENMKSSQTSGTNE-QSSAIVSA 781
+E+E K+ E LQS +L +K ++N S T NE + AI A
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1314
Query: 782 RDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIAT 841
+D VA L +L + L ++ + + T+ ++L ++ + ++ + E + +
Sbjct: 1315 KD---VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 842 KTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITD 901
+ + +LS ++ ++ + ++AL E + ++++++ DKLE
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1431
Query: 902 SKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKD 958
++E DDL+V L +Q Q + +L+ K + + EE + S DE D +E ++
Sbjct: 1432 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI-SSKYADERDRAEAEARE 1487
Score = 68.2 bits (165), Expect = 4e-11
Identities = 99/454 (21%), Positives = 185/454 (40%), Gaps = 98/454 (21%)
Query: 605 EYMIFDHEFTKLVKE---LEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIRE 661
E ++ D + KL KE LE I+ +EE++K + + K +H+++++ + +++
Sbjct: 993 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1052
Query: 662 QDL---------------------QLEELRQQVSTLKCQ----NEQLQTAVTQQVSQIQQ 696
++ Q+ +L+ Q++ LK Q E+LQ A+ + +I Q
Sbjct: 1053 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1112
Query: 697 HKDQYNLLKIQLGKDNQHQGSY-SEGAQMNGIQP------EEIGRLREEIEE-------- 741
+ ++ G + Q SE A N + EE+ L+ E+E+
Sbjct: 1113 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1172
Query: 742 ----LKRNQEL------LQSQLTEKDSMIENMKSSQTSGTNEQSSAI-----VSARDSEQ 786
KR QE+ L + ++ ++ M+ E + + A +
Sbjct: 1173 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 787 VAELKQELATLKSQLN-----SQSVE--ITKLQTEKQELLQK--------TEAFAKSVEV 831
L++E A L +L Q VE KL+ + QEL K E K ++
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 832 QGETETII---------ATKTTDVEGRLSALLQETKELKNE-----------IKALSEER 871
Q E E++ A K LS+ LQ+T+EL E ++ L EER
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 872 TAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLG 931
++++QLD L+ L ++++DSKK+ D + ++ + ++++L
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 932 HPVEEE----DELESGDQEDEDDESEDPGKDLDH 961
EE+ D+LE + E +D DLD+
Sbjct: 1413 QQYEEKAAAYDKLEK-TKNRLQQELDDLVVDLDN 1445
Score = 65.5 bits (158), Expect = 2e-10
Identities = 78/334 (23%), Positives = 147/334 (44%), Gaps = 62/334 (18%)
Query: 628 IYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLE-----ELRQQVSTLKCQNEQ 682
+ K+ E +K E K LEQ + +T KN+++EQ LQ E E + L + ++
Sbjct: 868 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ-LQAETELYAEAEEMRVRLAAKKQE 926
Query: 683 LQTAVTQQVSQIQQHKDQYNLLKIQLGK------DNQHQGSYSEGA----QMNGIQPE-E 731
L+ + + +++++ +D+ L+ + K D + Q E A Q+ + E +
Sbjct: 927 LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 986
Query: 732 IGRLREEI-------EELKRNQELLQSQLT----------EKDSMIENMKSSQTSGTNEQ 774
I +L +EI +L + ++LL+ +++ EK + +K+ S +E
Sbjct: 987 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1046
Query: 775 SSAIVSARDS-------------------EQVAELKQELATLKSQLNSQSVEI-TKLQTE 814
+ S EQ+A+L+ ++A LK QL + E+ L
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106
Query: 815 KQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAI 874
E+ QK A K E++G I+ D++ +A + K+ ++ L EE A+
Sbjct: 1107 DDEIAQKNNALKKIRELEGH----ISDLQEDLDSERAARNKAEKQKRD----LGEELEAL 1158
Query: 875 KEQLDSSNSTIAILQTEKDKLELEITDSKKEQDD 908
K +L+ + + A Q + K E E+T KK D+
Sbjct: 1159 KTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1192
Score = 55.1 bits (131), Expect = 3e-07
Identities = 68/310 (21%), Positives = 138/310 (44%), Gaps = 26/310 (8%)
Query: 660 REQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYS 719
+E +LQ + RQQ K +NE + + Q+ SQ+ + K NLL+ QL + +
Sbjct: 864 KEDELQKTKERQQ----KAENELKE--LEQKHSQLTEEK---NLLQEQLQAETELYAEAE 914
Query: 720 EGAQMNGIQPEEIGRLREEI-----EELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQ 774
E + +E+ + E+ EE R Q+L + M++ + + Q
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 974
Query: 775 SSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQEL---LQKTEAFAKSV-E 830
+ ++ +L+ E+ + Q N S E L+ +L L + E AK++ +
Sbjct: 975 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1034
Query: 831 VQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQT 890
++ + E++I +++E RL + +EL+ + L + + EQ+ + IA L+
Sbjct: 1035 LKNKHESMI----SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 891 EKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDD 950
+ K E E+ + DD + + +KI L+ + DL +E+ + E + +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL----QEDLDSERAARNKAEK 1146
Query: 951 ESEDPGKDLD 960
+ D G++L+
Sbjct: 1147 QKRDLGEELE 1156
Score = 52.4 bits (124), Expect = 2e-06
Identities = 89/450 (19%), Positives = 199/450 (44%), Gaps = 44/450 (9%)
Query: 525 QIAENLGEEEQLVQGLCALLLGISIYFND--NSLESYMKEK------LKQLIEKRIGKEN 576
Q+ NL ++++ L A IS + D + E+ +EK L + +E+ + +
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1507
Query: 577 FIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKA---IYKSSE 633
+E+ + K E+ S K HE K + LE + + + + +
Sbjct: 1508 ELERTNKMLKAEMEDLVSSKDDVGKNV-------HELEKSKRALETQMEEMKTQLEELED 1560
Query: 634 EDKKEEEVKKTLEQHDNIVT-HYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVS 692
E + E+ K LE + + ++ ++ +D Q EE R+Q L+ Q + +T + +
Sbjct: 1561 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ---LQRQLHEYETELEDERK 1617
Query: 693 Q-----IQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQE 747
Q + K + +L ++L D+ +G Q+ +Q + + + E+E+ + +++
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ-MKDFQRELEDARASRD 1676
Query: 748 LLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSE-QVAELKQELATLKSQLNSQSV 806
+ + E + +++++ + ++A + + ++ + EL +ELA+ S N+
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1736
Query: 807 E-------ITKLQTEKQELLQKTEAFA----KSVEVQGETETIIATKTTDVEGRLSALLQ 855
E I +L+ E +E EA + K+ + + +AT+ + + SA Q
Sbjct: 1737 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1796
Query: 856 ETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLAD 915
++ K L E A+K + STIA L+ + +LE ++ +E+ L
Sbjct: 1797 LERQNKELRSKLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1853
Query: 916 QDQKILSLKNKLKDLGHPVEE-EDELESGD 944
+D+K+ + +++D E+ +++ E G+
Sbjct: 1854 KDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883
Score = 51.2 bits (121), Expect = 5e-06
Identities = 62/272 (22%), Positives = 115/272 (42%), Gaps = 24/272 (8%)
Query: 687 VTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIE---ELK 743
VT+Q ++Q +D+ K + + + E Q + EE L+E+++ EL
Sbjct: 854 VTRQEEEMQAKEDELQKTK---ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 744 RNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELK---QELATLKSQ 800
E ++ +L K +E + + E+ R + AE K Q++ L+ Q
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEED-----RGQQLQAERKKMAQQMLDLEEQ 965
Query: 801 LNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKEL 860
L + KLQ EK K + + V + ++ + +E R+S L E
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 861 KNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQD--DLLVLLADQDQ 918
+ + K L++ + K + S + + + EK + ELE K E D D +AD
Sbjct: 1026 EEKAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083
Query: 919 KILSLKNKLKDLGHPVEEEDELESGDQEDEDD 950
+I LK +L ++E+EL++ +D+
Sbjct: 1084 QIAELKMQL------AKKEEELQAALARLDDE 1109
Score = 51.2 bits (121), Expect = 5e-06
Identities = 64/354 (18%), Positives = 145/354 (40%), Gaps = 34/354 (9%)
Query: 618 KELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLK 677
K+LE + + K S+ ++ E+ + + N V M+ E + + +L + V++L
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 678 CQNEQLQTAVTQQVSQ-------IQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPE 730
Q + Q + ++ Q ++Q +++ N L+ QL ++ + + + IQ
Sbjct: 1322 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1381
Query: 731 E-----------IGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIV 779
+ + L E + ++ E L Q EK + + ++ ++ E +V
Sbjct: 1382 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1441
Query: 780 SARDSEQVA--------ELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEV 831
+ Q+ + Q LA K+ + + E + + E +E K + A+++E
Sbjct: 1442 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1501
Query: 832 QGE-------TETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNST 884
E T ++ + D+ + + EL+ +AL + +K QL+
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 885 IAILQTEKDKLELEITDSKKE-QDDLLVLLADQDQKILSLKNKLKDLGHPVEEE 937
+ + K +LE+ + K + + DL ++K L+ +L + +E+E
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1615
Score = 39.7 bits (91), Expect = 0.014
Identities = 51/288 (17%), Positives = 119/288 (41%), Gaps = 26/288 (9%)
Query: 561 KEKLKQLIEKRIGKENFIEKL--GFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVK 618
+E +KQL + + ++F +L S+ E+++ A + + + + + +L +
Sbjct: 1648 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK------KAKSLEADLMQLQE 1701
Query: 619 ELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNI----------VTHYKNMIREQDLQLEE 668
+L E+++ EE+ +L + + + + + E+ +E
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 669 LRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQ 728
+ +V Q EQL + + S Q+++ L+ Q K+ + + EGA + +
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ-NKELRSKLHEMEGAVKSKFK 1820
Query: 729 PE------EIGRLREEIEELKRNQELLQSQLTEKDSMI-ENMKSSQTSGTNEQSSAIVSA 781
+I +L E++E+ R ++ L +KD + E + + + +
Sbjct: 1821 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880
Query: 782 RDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSV 829
+ + +V +LK++L + + + KLQ E E + EA + V
Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1928
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 75.9 bits (185), Expect = 2e-13
Identities = 100/477 (20%), Positives = 209/477 (43%), Gaps = 51/477 (10%)
Query: 526 IAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRIGK-----ENFIEK 580
+ NL EEE+ + L L ++ + +EK +Q +EK K +F E+
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070
Query: 581 LGFIS------KHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVIT--------- 625
+ + K +L + + + + + K ++ELEG I+
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 626 KAIYKSSEEDKKE-----EEVKKTLEQH-DNIVTHYK-NMIREQDLQL--EELRQQVSTL 676
+A +E+ K++ E +K LE D+ T + REQ++ + + L ++ +
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190
Query: 677 KCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLR 736
+ Q ++++ Q V ++ + +Q+ K L K+ Q E A + G + +G+ +
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEK--ENADLAG-ELRVLGQAK 1247
Query: 737 EEIEELKRNQEL----LQS----------QLTEKDSMIENMKSSQTSGTNE-QSSAIVSA 781
+E+E K+ E LQS +L +K ++N S T NE + AI A
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLA 1307
Query: 782 RDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIAT 841
+D VA L +L + L ++ + + T+ ++L ++ + ++ + E + +
Sbjct: 1308 KD---VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 842 KTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITD 901
+ + +LS ++ ++ + ++AL E + ++++++ DKLE
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR 1424
Query: 902 SKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKD 958
++E DDL+V L +Q Q + +L+ K + + EE + S DE D +E ++
Sbjct: 1425 LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI-SSKYADERDRAEAEARE 1480
Score = 68.2 bits (165), Expect = 4e-11
Identities = 99/454 (21%), Positives = 185/454 (40%), Gaps = 98/454 (21%)
Query: 605 EYMIFDHEFTKLVKE---LEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIRE 661
E ++ D + KL KE LE I+ +EE++K + + K +H+++++ + +++
Sbjct: 986 EILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKK 1045
Query: 662 QDL---------------------QLEELRQQVSTLKCQ----NEQLQTAVTQQVSQIQQ 696
++ Q+ +L+ Q++ LK Q E+LQ A+ + +I Q
Sbjct: 1046 EEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1105
Query: 697 HKDQYNLLKIQLGKDNQHQGSY-SEGAQMNGIQP------EEIGRLREEIEE-------- 741
+ ++ G + Q SE A N + EE+ L+ E+E+
Sbjct: 1106 KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQ 1165
Query: 742 ----LKRNQEL------LQSQLTEKDSMIENMKSSQTSGTNEQSSAI-----VSARDSEQ 786
KR QE+ L + ++ ++ M+ E + + A +
Sbjct: 1166 QELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 787 VAELKQELATLKSQLN-----SQSVE--ITKLQTEKQELLQK--------TEAFAKSVEV 831
L++E A L +L Q VE KL+ + QEL K E K ++
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 832 QGETETII---------ATKTTDVEGRLSALLQETKELKNE-----------IKALSEER 871
Q E E++ A K LS+ LQ+T+EL E ++ L EER
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 872 TAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLG 931
++++QLD L+ L ++++DSKK+ D + ++ + ++++L
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 932 HPVEEE----DELESGDQEDEDDESEDPGKDLDH 961
EE+ D+LE + E +D DLD+
Sbjct: 1406 QQYEEKAAAYDKLEK-TKNRLQQELDDLVVDLDN 1438
Score = 65.5 bits (158), Expect = 2e-10
Identities = 78/334 (23%), Positives = 147/334 (44%), Gaps = 62/334 (18%)
Query: 628 IYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLE-----ELRQQVSTLKCQNEQ 682
+ K+ E +K E K LEQ + +T KN+++EQ LQ E E + L + ++
Sbjct: 861 LQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ-LQAETELYAEAEEMRVRLAAKKQE 919
Query: 683 LQTAVTQQVSQIQQHKDQYNLLKIQLGK------DNQHQGSYSEGA----QMNGIQPE-E 731
L+ + + +++++ +D+ L+ + K D + Q E A Q+ + E +
Sbjct: 920 LEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAK 979
Query: 732 IGRLREEI-------EELKRNQELLQSQLT----------EKDSMIENMKSSQTSGTNEQ 774
I +L +EI +L + ++LL+ +++ EK + +K+ S +E
Sbjct: 980 IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISEL 1039
Query: 775 SSAIVSARDS-------------------EQVAELKQELATLKSQLNSQSVEI-TKLQTE 814
+ S EQ+A+L+ ++A LK QL + E+ L
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099
Query: 815 KQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAI 874
E+ QK A K E++G I+ D++ +A + K+ ++ L EE A+
Sbjct: 1100 DDEIAQKNNALKKIRELEGH----ISDLQEDLDSERAARNKAEKQKRD----LGEELEAL 1151
Query: 875 KEQLDSSNSTIAILQTEKDKLELEITDSKKEQDD 908
K +L+ + + A Q + K E E+T KK D+
Sbjct: 1152 KTELEDTLDSTATQQELRAKREQEVTVLKKALDE 1185
Score = 55.1 bits (131), Expect = 3e-07
Identities = 68/310 (21%), Positives = 138/310 (44%), Gaps = 26/310 (8%)
Query: 660 REQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYS 719
+E +LQ + RQQ K +NE + + Q+ SQ+ + K NLL+ QL + +
Sbjct: 857 KEDELQKTKERQQ----KAENELKE--LEQKHSQLTEEK---NLLQEQLQAETELYAEAE 907
Query: 720 EGAQMNGIQPEEIGRLREEI-----EELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQ 774
E + +E+ + E+ EE R Q+L + M++ + + Q
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQ 967
Query: 775 SSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQEL---LQKTEAFAKSV-E 830
+ ++ +L+ E+ + Q N S E L+ +L L + E AK++ +
Sbjct: 968 KLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTK 1027
Query: 831 VQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQT 890
++ + E++I +++E RL + +EL+ + L + + EQ+ + IA L+
Sbjct: 1028 LKNKHESMI----SELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 891 EKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDD 950
+ K E E+ + DD + + +KI L+ + DL +E+ + E + +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDL----QEDLDSERAARNKAEK 1139
Query: 951 ESEDPGKDLD 960
+ D G++L+
Sbjct: 1140 QKRDLGEELE 1149
Score = 52.4 bits (124), Expect = 2e-06
Identities = 89/450 (19%), Positives = 199/450 (44%), Gaps = 44/450 (9%)
Query: 525 QIAENLGEEEQLVQGLCALLLGISIYFND--NSLESYMKEK------LKQLIEKRIGKEN 576
Q+ NL ++++ L A IS + D + E+ +EK L + +E+ + +
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE 1500
Query: 577 FIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKA---IYKSSE 633
+E+ + K E+ S K HE K + LE + + + + +
Sbjct: 1501 ELERTNKMLKAEMEDLVSSKDDVGKNV-------HELEKSKRALETQMEEMKTQLEELED 1553
Query: 634 EDKKEEEVKKTLEQHDNIVT-HYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVS 692
E + E+ K LE + + ++ ++ +D Q EE R+Q L+ Q + +T + +
Sbjct: 1554 ELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ---LQRQLHEYETELEDERK 1610
Query: 693 Q-----IQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQE 747
Q + K + +L ++L D+ +G Q+ +Q + + + E+E+ + +++
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQ-MKDFQRELEDARASRD 1669
Query: 748 LLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSE-QVAELKQELATLKSQLNSQSV 806
+ + E + +++++ + ++A + + ++ + EL +ELA+ S N+
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1729
Query: 807 E-------ITKLQTEKQELLQKTEAFA----KSVEVQGETETIIATKTTDVEGRLSALLQ 855
E I +L+ E +E EA + K+ + + +AT+ + + SA Q
Sbjct: 1730 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1789
Query: 856 ETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLAD 915
++ K L E A+K + STIA L+ + +LE ++ +E+ L
Sbjct: 1790 LERQNKELRSKLHEMEGAVKSKF---KSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQ 1846
Query: 916 QDQKILSLKNKLKDLGHPVEE-EDELESGD 944
+D+K+ + +++D E+ +++ E G+
Sbjct: 1847 KDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876
Score = 51.2 bits (121), Expect = 5e-06
Identities = 62/272 (22%), Positives = 115/272 (42%), Gaps = 24/272 (8%)
Query: 687 VTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIE---ELK 743
VT+Q ++Q +D+ K + + + E Q + EE L+E+++ EL
Sbjct: 847 VTRQEEEMQAKEDELQKTK---ERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 744 RNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELK---QELATLKSQ 800
E ++ +L K +E + + E+ R + AE K Q++ L+ Q
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEED-----RGQQLQAERKKMAQQMLDLEEQ 958
Query: 801 LNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKEL 860
L + KLQ EK K + + V + ++ + +E R+S L E
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 861 KNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQD--DLLVLLADQDQ 918
+ + K L++ + K + S + + + EK + ELE K E D D +AD
Sbjct: 1019 EEKAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076
Query: 919 KILSLKNKLKDLGHPVEEEDELESGDQEDEDD 950
+I LK +L ++E+EL++ +D+
Sbjct: 1077 QIAELKMQL------AKKEEELQAALARLDDE 1102
Score = 51.2 bits (121), Expect = 5e-06
Identities = 64/354 (18%), Positives = 145/354 (40%), Gaps = 34/354 (9%)
Query: 618 KELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLK 677
K+LE + + K S+ ++ E+ + + N V M+ E + + +L + V++L
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 678 CQNEQLQTAVTQQVSQ-------IQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPE 730
Q + Q + ++ Q ++Q +++ N L+ QL ++ + + + IQ
Sbjct: 1315 SQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLS 1374
Query: 731 E-----------IGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIV 779
+ + L E + ++ E L Q EK + + ++ ++ E +V
Sbjct: 1375 DSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVV 1434
Query: 780 SARDSEQVA--------ELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEV 831
+ Q+ + Q LA K+ + + E + + E +E K + A+++E
Sbjct: 1435 DLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEE 1494
Query: 832 QGE-------TETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNST 884
E T ++ + D+ + + EL+ +AL + +K QL+
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 885 IAILQTEKDKLELEITDSKKE-QDDLLVLLADQDQKILSLKNKLKDLGHPVEEE 937
+ + K +LE+ + K + + DL ++K L+ +L + +E+E
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDE 1608
Score = 39.7 bits (91), Expect = 0.014
Identities = 51/288 (17%), Positives = 119/288 (41%), Gaps = 26/288 (9%)
Query: 561 KEKLKQLIEKRIGKENFIEKL--GFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVK 618
+E +KQL + + ++F +L S+ E+++ A + + + + + +L +
Sbjct: 1641 EEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEK------KAKSLEADLMQLQE 1694
Query: 619 ELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNI----------VTHYKNMIREQDLQLEE 668
+L E+++ EE+ +L + + + + + E+ +E
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 669 LRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQ 728
+ +V Q EQL + + S Q+++ L+ Q K+ + + EGA + +
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ-NKELRSKLHEMEGAVKSKFK 1813
Query: 729 PE------EIGRLREEIEELKRNQELLQSQLTEKDSMI-ENMKSSQTSGTNEQSSAIVSA 781
+I +L E++E+ R ++ L +KD + E + + + +
Sbjct: 1814 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1873
Query: 782 RDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSV 829
+ + +V +LK++L + + + KLQ E E + EA + V
Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREV 1921
>gi|82880656 coiled-coil domain containing 46 isoform a [Homo
sapiens]
Length = 955
Score = 75.5 bits (184), Expect = 2e-13
Identities = 100/424 (23%), Positives = 184/424 (43%), Gaps = 66/424 (15%)
Query: 563 KLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEG 622
K +IE+ ++N + + + EL + + Q N E H + K +L+
Sbjct: 501 KASSMIEEL--EQNVCQLKQQLQESELQRKQQLRDQENKFQMEKSHLKHIYEKKAHDLQS 558
Query: 623 VITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQ-DLQLEELRQQVSTLKCQNE 681
+ K + ++ K EE K E+ VT + + +Q D LEE ++QV + +E
Sbjct: 559 ELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQRLQAQQADAALEEFKRQV---ELNSE 615
Query: 682 QLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEE 741
++ + +Q+ +++ + L+ + K+ Q + I+ R ++I E
Sbjct: 616 KVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQ--------LEDIRQ----RYEQQIVE 663
Query: 742 LKRNQE-----LLQSQLTEKDSM-------IENMKSSQTSGTNEQSSAI--VSARDSE-- 785
LK E LLQ EKDS+ IEN++ + E + I RD++
Sbjct: 664 LKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEHENQIQEFKKRDAQVI 723
Query: 786 -----QVAELKQELATLKSQLNSQSVEITKL-QTEKQELLQKTEAFAKSVEVQGETETII 839
QV +L++EL + SQ Q VE+ L + EKQ ++ E ++ + E I
Sbjct: 724 ADMEAQVHKLREELINVNSQRKQQLVELGLLREEEKQRATREHEIVVNKLKAESEKMKIE 783
Query: 840 ATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEI 899
KT E ++ ++ +++K + +E T ++L S+ IA LQT L+ E
Sbjct: 784 LKKTHAAETEMT-----LEKANSKLKQIEKEYT---QKLAKSSQIIAELQTTISSLKEEN 835
Query: 900 TDS------------KKEQDDLLVLLADQDQKILSLKNKLKDLGHPVE------EEDELE 941
+ +K +D+ L+ D DQ I L+++L++ + V + ELE
Sbjct: 836 SQQQLAAERRLQDVRQKFEDEKKQLIRDNDQAIKVLQDELENRSNQVRCAEKKLQHKELE 895
Query: 942 SGDQ 945
S +Q
Sbjct: 896 SQEQ 899
Score = 45.1 bits (105), Expect = 3e-04
Identities = 97/476 (20%), Positives = 196/476 (41%), Gaps = 75/476 (15%)
Query: 551 FNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIF- 609
F+D+ S ++EK + K + + EKL KH+ + + + N ++
Sbjct: 243 FHDDHFLSRIREKELDMKTKMMEAKFHEEKLKLQQKHDADVQKILERKNNEIEELKTLYR 302
Query: 610 --DHEFTKLVKELEGVITKAIYKSS--EEDKKEE--EVKKTLEQHDNIVTH-----YKNM 658
HE + +++LE + I E K+++ E+KK EQ + + N
Sbjct: 303 SKQHETEETIRKLEKKVQTLIRDCQVIRETKEDQIAELKKICEQSTESLNNDWEKKLHNA 362
Query: 659 IREQ-----DLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQ 713
+ E DLQ + L+ N +L ++ ++Q Q L+ ++ Q
Sbjct: 363 VAEMEQEKFDLQKQHTENIQELLEDTNVRLNKMESEYMAQTQSTNHMIKELEARV---QQ 419
Query: 714 HQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTN- 772
G A+ + +Q + +L +E EL+R ++ S+L E + + + N
Sbjct: 420 LTGE----AENSNLQRQ---KLIQEKAELERCYQITCSELQEVKARRNTLHKEKDHLVND 472
Query: 773 -EQSSAIVSARDSEQVAELKQELATLKSQLNS------QSVEITKLQTEKQELLQKTEAF 825
EQ+ ++ + + LKQE A S+ +S Q+V K Q ++ EL +K +
Sbjct: 473 YEQNMKLLQTKYDADINLLKQEHALSASKASSMIEELEQNVCQLKQQLQESELQRKQQLR 532
Query: 826 AKSVEVQGE---TETIIATKTTDVEGRLSALLQET-----------KELKNEIKALSEER 871
+ + Q E + I K D++ L ++T KE + ++ ++E +
Sbjct: 533 DQENKFQMEKSHLKHIYEKKAHDLQSELDKGKEDTQKKIHKFEEALKEKEEQLTRVTEVQ 592
Query: 872 TAIKEQLD------------SSNSTIAILQTEKDKLELEITDSK----KEQDDLLVLLAD 915
+Q D +S A ++ + +K+E ++T SK K+ + L L D
Sbjct: 593 RLQAQQADAALEEFKRQVELNSEKVYAEMKEQMEKVEADLTRSKSLREKQSKEFLWQLED 652
Query: 916 ----QDQKILSLKNKLKD------LGHPVEEEDELESGDQEDEDDESEDPGKDLDH 961
+Q+I+ LK + + H E++ + ++E E+ E + +++H
Sbjct: 653 IRQRYEQQIVELKLEHEQEKTHLLQQHNAEKDSLVRDHEREIENLEKQLRAANMEH 708
Score = 39.3 bits (90), Expect = 0.018
Identities = 49/220 (22%), Positives = 96/220 (43%), Gaps = 37/220 (16%)
Query: 607 MIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKT--------LEQHDN----IVTH 654
++ + E + +E E V+ K +E +K + E+KKT LE+ ++ I
Sbjct: 753 LLREEEKQRATREHEIVVNKL---KAESEKMKIELKKTHAAETEMTLEKANSKLKQIEKE 809
Query: 655 YKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQH 714
Y + + + EL+ +S+LK +N Q Q A +++ ++Q ++ K QL +DN
Sbjct: 810 YTQKLAKSSQIIAELQTTISSLKEENSQQQLAAERRLQDVRQ---KFEDEKKQLIRDND- 865
Query: 715 QGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQ 774
+ I L++E+E + +L K+ +E+ + T E
Sbjct: 866 ---------------QAIKVLQDELENRSNQVRCAEKKLQHKE--LESQEQI-TYIRQEY 907
Query: 775 SSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTE 814
+ + + EL+ +++LKSQ+N + LQ E
Sbjct: 908 ETKLKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEE 947
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 74.7 bits (182), Expect = 4e-13
Identities = 85/385 (22%), Positives = 169/385 (43%), Gaps = 52/385 (13%)
Query: 605 EYMIFDHEFTKLVKE---LEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIRE 661
E +I + + KL KE LE I + +EE++K + + K +H+ ++T + +R
Sbjct: 979 EQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRR 1038
Query: 662 QDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSY--- 718
++ Q +EL + L+ + L + + +QI + LK+QL K + +
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE-------LKMQLAKKEEELQAALAR 1091
Query: 719 --SEGAQMNGIQPE------EIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSS--QT 768
E AQ N + +I L+E++E + ++ + Q + +E +K+ T
Sbjct: 1092 VEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT 1151
Query: 769 SGTNEQSSAIVSARDSE-----------------QVAELKQELATLKSQLNSQSVEITK- 810
+ + S R+ E Q+ E++Q+ + +L Q +E TK
Sbjct: 1152 LDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ-LEQTKR 1210
Query: 811 ----LQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKA 866
L+ KQ L + A V+V + + K VE +L L + E +
Sbjct: 1211 VKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTE 1270
Query: 867 LSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNK 926
L+++ T ++ +LD+ ++ ++ KL + + + + D LL +++++ LSL K
Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTK 1330
Query: 927 LKDLGHPVEEEDELESGDQEDEDDE 951
LK + EDE S ++ E++E
Sbjct: 1331 LKQV------EDEKNSFREQLEEEE 1349
Score = 71.2 bits (173), Expect = 4e-12
Identities = 86/416 (20%), Positives = 167/416 (40%), Gaps = 73/416 (17%)
Query: 615 KLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVS 674
KL + E +IT + E+K+ +E++KT + + T + I E Q+ EL+ Q++
Sbjct: 1020 KLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA 1079
Query: 675 TLKCQNEQLQTAVTQ--------------------QVSQIQQHKDQYNLLKIQLGKDNQH 714
+ E+LQ A+ + Q+S++Q+ + + + K +
Sbjct: 1080 K---KEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRD 1136
Query: 715 QGSYSEGA---------------QMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSM 759
G E ++ + +E+ L++ +EE + E ++ +K S
Sbjct: 1137 LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ 1196
Query: 760 IENMKSSQTSGTNEQSSAIVSARDS--EQVAELKQELATLKSQLNSQSVEITKLQTEKQE 817
+ Q T + + A+ + + EL E+ L + K++ + QE
Sbjct: 1197 AVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQE 1256
Query: 818 LLQK--------TEAFAKSVEVQGETETII---------ATKTTDVEGRLSALLQETKEL 860
L K TE K ++Q E + + ++K T L + LQ+T+EL
Sbjct: 1257 LQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQEL 1316
Query: 861 KNE-----------IKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDL 909
E +K + +E+ + +EQL+ L+ + L ++ D KK+ +D
Sbjct: 1317 LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS 1376
Query: 910 LVLLADQDQKILSLKNKLKDLGHPVEEE----DELESGDQEDEDDESEDPGKDLDH 961
+ L ++ L+ L+ L EE+ D+LE + E +D DLDH
Sbjct: 1377 VGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK-TKTRLQQELDDLLVDLDH 1431
Score = 63.5 bits (153), Expect = 9e-10
Identities = 75/366 (20%), Positives = 163/366 (44%), Gaps = 32/366 (8%)
Query: 594 SQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEV---KKTLEQHDN 650
S++ N + E L ELE + + K+E+EV KKTLE+
Sbjct: 1122 SERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAK 1181
Query: 651 IVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKD-QYNLLKIQLG 709
TH + Q++E+RQ+ S AV + Q++Q K + NL K +
Sbjct: 1182 --TH--------EAQIQEMRQKHSQ----------AVEELAEQLEQTKRVKANLEKAKQT 1221
Query: 710 KDNQHQGSYSEGA---QMNGIQPEEIGRLREEIEELK---RNQELLQSQLTEKDSMIENM 763
+N+ +E Q G + ++ +++EL+ E ++++L +K + ++ +
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ-V 1280
Query: 764 KSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTE 823
+ +G QS + S++ ++ + L+ +L + L ++ + L T+ +++ +
Sbjct: 1281 ELDNVTGLLSQSDS-KSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKN 1339
Query: 824 AFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNS 883
+F + +E + E + + + + +++ + ++ ++ ++ E + +++ L+ +
Sbjct: 1340 SFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQ 1399
Query: 884 TIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESG 943
DKLE T ++E DDLLV L Q Q +L+ K K + EE + +
Sbjct: 1400 RHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAK 1459
Query: 944 DQEDED 949
E+ D
Sbjct: 1460 YAEERD 1465
Score = 58.2 bits (139), Expect = 4e-08
Identities = 76/336 (22%), Positives = 163/336 (48%), Gaps = 55/336 (16%)
Query: 637 KEEEVKKTLEQH---DNIVTHYKNM---IREQDLQLEELRQQVSTLKCQNEQLQTAVTQQ 690
KEEE+ K E+ +N +T + + + + LQL+E Q + L + E+L+ +T +
Sbjct: 850 KEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAK 909
Query: 691 VSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQ 750
+++ ++ D + + E E L+ E +++++N + L+
Sbjct: 910 KQELE-----------EICHDLEARVEEEE---------ERCQHLQAEKKKMQQNIQELE 949
Query: 751 SQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQ--ELATLKSQLNSQSVEI 808
QL E++S + ++ + + + A + + EQ+ Q +LA K L + E
Sbjct: 950 EQLEEEESARQKLQLEKVT-----TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEF 1004
Query: 809 TKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALS 868
T TE++E K+++ AK ++ + E +I TD+E RL ++ +EL+ + L
Sbjct: 1005 TTNLTEEEE---KSKSLAK---LKNKHEAMI----TDLEERLRREEKQRQELEKTRRKLE 1054
Query: 869 EERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQ-DQKILSLKNKL 927
+ T + +Q IA LQ + +L++++ ++E L + ++ QK ++LK K+
Sbjct: 1055 GDSTDLSDQ-------IAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALK-KI 1106
Query: 928 KDLGHPVEE-EDELES--GDQEDEDDESEDPGKDLD 960
++L + E +++LES + + + D G++L+
Sbjct: 1107 RELESQISELQEDLESERASRNKAEKQKRDLGEELE 1142
Score = 55.5 bits (132), Expect = 2e-07
Identities = 72/355 (20%), Positives = 148/355 (41%), Gaps = 31/355 (8%)
Query: 617 VKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTL 676
+K+LE I A +K +E K L + + K+ +RE D R+++
Sbjct: 1619 LKDLEAHIDSA-------NKNRDEAIKQLRK---LQAQMKDCMRELD-DTRASREEILAQ 1667
Query: 677 KCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEE----- 731
+NE+ ++ ++ Q+Q+ K Q ++ + G E
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRL 1727
Query: 732 ---IGRLREEIEELKRNQELLQSQLTEKDSMIENMKSS-QTSGTNEQSSAIVSARDSEQV 787
I +L EE+EE + N EL+ +L + + I+ + + ++ Q + + Q
Sbjct: 1728 EARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQN 1787
Query: 788 AELKQELATLKSQLNSQ-SVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDV 846
ELK +L ++ + S+ IT L+ + +L ++ + K + + K DV
Sbjct: 1788 KELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDV 1847
Query: 847 EGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQ 906
++ + ++ K++ S +K QL+ + + KL+ E+ D+ +
Sbjct: 1848 LLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETA 1907
Query: 907 DDLLVLLADQDQKILSLKNKLK--DLGHPVEEEDELE-SGDQEDEDDESEDPGKD 958
D + ++++ SLKNKL+ DL V + +GD DE+ + + G +
Sbjct: 1908 DAM-------NREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKADGAE 1955
Score = 51.6 bits (122), Expect = 3e-06
Identities = 80/431 (18%), Positives = 172/431 (39%), Gaps = 45/431 (10%)
Query: 561 KEKLKQLIEKRIG---------KENFIEKLGFISKHELYSRASQKPQPNFPSPE------ 605
+E+ K +EK+I K+ + +G + E R QK
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAA 1407
Query: 606 YMIFDHEFTKLVKELEGVITKAIYKSSEE---DKKEEEVKKTLEQHDNIVTHYKNMIREQ 662
Y + T+L +EL+ ++ ++ +KK+++ + L + I Y E+
Sbjct: 1408 YDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAE---ER 1464
Query: 663 DLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGA 722
D E R++ + L+ A+ Q+ + +K ++ + + S E
Sbjct: 1465 DRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELE 1524
Query: 723 QMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSS---QTSGTNEQSSAIV 779
+ +++ ++ ++EEL+ + + + ++ MK+ G +EQS
Sbjct: 1525 KSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEE-K 1583
Query: 780 SARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQEL--------LQKTEAFAKSVEV 831
+ QV E++ EL + Q + KL+ + ++L + EA + ++
Sbjct: 1584 KKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKL 1643
Query: 832 QGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTE 891
Q + + + + D +L + KE + ++K++ E ++E+L ++ Q E
Sbjct: 1644 QAQMKDCMR-ELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQE 1702
Query: 892 KDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDE 951
+D+L EI +S + + L K +L+ +EEE E E G+ E +D
Sbjct: 1703 RDELADEIANS-----------SGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDR 1751
Query: 952 SEDPGKDLDHI 962
+ +D I
Sbjct: 1752 LKKANLQIDQI 1762
Score = 51.2 bits (121), Expect = 5e-06
Identities = 44/167 (26%), Positives = 80/167 (47%), Gaps = 10/167 (5%)
Query: 765 SSQTSGTNEQSSAIVSARDSEQVAELK-QELATLKSQLNSQSVEITK-LQTEKQELLQKT 822
S Q + +V R+ + AE + E+ TL+SQL ++ +++ + LQ E + +
Sbjct: 841 SRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAE 900
Query: 823 EAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSN 882
E A+ + E E I D+E R+ + + L+ E K + + ++EQL+
Sbjct: 901 ELRARLTAKKQELEEICH----DLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEE 956
Query: 883 STIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKD 929
S LQ EK E ++ ++EQ ++L DQ+ K+ K L+D
Sbjct: 957 SARQKLQLEKVTTEAKLKKLEEEQ----IILEDQNCKLAKEKKLLED 999
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 73.2 bits (178), Expect = 1e-12
Identities = 78/406 (19%), Positives = 178/406 (43%), Gaps = 56/406 (13%)
Query: 612 EFTKLVKELEGV---ITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEE 668
E KL ++LE I + + E K + + L+ + +T+ + + E E
Sbjct: 743 EMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET 802
Query: 669 LRQQVSTLKCQNEQ-------LQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQH------- 714
L +++ LK + + +Q ++ + V+++ Q ++Q+N+L L K ++
Sbjct: 803 LEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAK 862
Query: 715 ------------------QGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEK 756
+ +E +M+G ++ ++ +E+ +R+ E LQ +LT+
Sbjct: 863 FREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKA 922
Query: 757 DSMIENMKSSQTSGT--NEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTE 814
+ ++ S T EQS + + E+ EL+++L+ L+ ++ + + +L+
Sbjct: 923 NENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR 982
Query: 815 KQELLQKTEAFAKSVEVQGETETIIAT--KTTDVEGRLSALLQETKELKNE--------- 863
+ +T+ + + +Q +T++ T K S LLQE +EL+ +
Sbjct: 983 YERATSETKTKHEEI-LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQT 1041
Query: 864 -------IKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQ 916
++ +++E+T L+ + T A LQ E D L+ + +E + LL +
Sbjct: 1042 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1101
Query: 917 DQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDHI 962
+QK+ + +++ L ++ + S QE+ +E+ G+ D +
Sbjct: 1102 NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1147
Score = 67.8 bits (164), Expect = 5e-11
Identities = 97/383 (25%), Positives = 163/383 (42%), Gaps = 81/383 (21%)
Query: 616 LVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVST 675
L K +E + KA E KK EE KK LE+ + + + ++E Q
Sbjct: 929 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERK----------LSDLEKKMETSHNQCQE 978
Query: 676 LKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRL 735
LK + E+ + + +I Q NL K L +++ +G+ EE L
Sbjct: 979 LKARYERATSETKTKHEEILQ-----NLQKTLLDTEDKLKGAR-----------EENSGL 1022
Query: 736 REEIEELKRNQELLQSQLTEKDSM--IENMKSSQTSGTNEQSSAIVSARDSEQV-AELKQ 792
+E+EEL++ + ++ T +D+M +E M T E++ + S D++Q A+L+
Sbjct: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQM-------TKEKTETLASLEDTKQTNAKLQN 1075
Query: 793 ELATLKSQLNSQSVEITKLQTEKQELL---QKTEAFAKSVEVQGETETIIATKTTDVEGR 849
EL TLK N ++VE +L K+ L QK E F K +E + + + + ++
Sbjct: 1076 ELDTLKEN-NLKNVE--ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1132
Query: 850 LSALLQETKELKNEIKA---LSEERTAIKEQL---------------------DSSNSTI 885
L +E ++E+ + L EER+ + QL S S
Sbjct: 1133 NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISIT 1192
Query: 886 AILQTEKD----KLELEITDSKKEQDDL-----LVLLADQDQKILSLKNKLKDLGHPVEE 936
+ L TEKD KL E+T + E +V + D+ L LK K +L E
Sbjct: 1193 SALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL-QLKEN 1251
Query: 937 EDELESGD-----QEDEDDESED 954
+ +L S Q DED+ +++
Sbjct: 1252 KRQLSSSSGNTDTQADEDERAQE 1274
Score = 60.8 bits (146), Expect = 6e-09
Identities = 75/348 (21%), Positives = 153/348 (43%), Gaps = 38/348 (10%)
Query: 610 DHEFTKLVKELEGV---ITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQL 666
+ +F L +LE + + K E+D++EE++ K E+ +N + M + QL
Sbjct: 839 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 898
Query: 667 EELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNG 726
++ ++ + E+LQ +T K N +Q K + +E +Q
Sbjct: 899 TKMNDELRLKERDVEELQLKLT---------KANENASFLQ--KSIEDMTVKAEQSQQEA 947
Query: 727 IQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQ 786
+ E EE +EL+R L+ ++ + + +K+ T+E + + E
Sbjct: 948 AKKHE-----EEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT-----KHEEI 997
Query: 787 VAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDV 846
+ L++ L + +L E + L E +EL ++ + AK+ + + I+ T +
Sbjct: 998 LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK-AKAAQTAEDAMQIMEQMTKEK 1056
Query: 847 EGRLSALLQETKE----LKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDS 902
L++L ++TK+ L+NE+ L E E+L+ S +L E K+E +
Sbjct: 1057 TETLASL-EDTKQTNAKLQNELDTLKENNLKNVEELNKSKE---LLTVENQKME----EF 1108
Query: 903 KKEQDDLLVLLADQDQKILSLKNKLKDLGHPV-EEEDELESGDQEDED 949
+KE + L A + Q++ +L+ + L + DE+ S + +E+
Sbjct: 1109 RKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEE 1156
Score = 51.2 bits (121), Expect = 5e-06
Identities = 67/294 (22%), Positives = 132/294 (44%), Gaps = 40/294 (13%)
Query: 561 KEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKEL 620
++KLK E+ G +++L + K ++A+Q + E M E T+ + L
Sbjct: 1009 EDKLKGAREENSG---LLQELEELRKQADKAKAAQTAEDAMQIMEQMT--KEKTETLASL 1063
Query: 621 EGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQN 680
E +E D +E K +E+ + K ++ ++ ++EE R+++ TLK
Sbjct: 1064 EDTKQTNAKLQNELDTLKENNLKNVEE----LNKSKELLTVENQKMEEFRKEIETLK--- 1116
Query: 681 EQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLR---- 736
Q +QQ+S +Q+ + L +LG+ S+ + + + ++ ++
Sbjct: 1117 -QAAAQKSQQLSALQEENVK---LAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRES 1172
Query: 737 -------EEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSA-----IVSARDS 784
EE L+++ + + LTEKD+ +E +++ T E +SA +V +S
Sbjct: 1173 KFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLES 1232
Query: 785 E------QVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEA-FAKSVEV 831
+ +V L+ +L K QL+S S T Q ++ E Q+++ F SV V
Sbjct: 1233 DKVKLELKVKNLELQLKENKRQLSSSSGN-TDTQADEDERAQESQIDFLNSVIV 1285
Score = 43.1 bits (100), Expect = 0.001
Identities = 62/339 (18%), Positives = 136/339 (40%), Gaps = 18/339 (5%)
Query: 612 EFTKLVKELE-----GVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQL 666
E +L + LE G + ++ E +E+++ T H +T K ++
Sbjct: 479 EVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGARE--- 535
Query: 667 EELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNG 726
E ++++ L E+L S+++ H ++ N I L K S M
Sbjct: 536 ETHQKEIKALYTATEKLSKENESLKSKLE-HANKENSDVIALWKSKLETAIASHQQAMEE 594
Query: 727 IQ---PEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARD 783
++ + +G E ELK E ++ + ++N + S+ + ++ A+ A+
Sbjct: 595 LKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEAL-RAKL 653
Query: 784 SEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKT 843
+ + E + L ++S+L+ + + LQ+ E K +EV +
Sbjct: 654 MKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAK----CNEQ 709
Query: 844 TDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSK 903
T V ++ L+ T+E ++ AL + + K ++ + + + LE+E
Sbjct: 710 TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAES 769
Query: 904 KEQDDLLVLLADQDQKILSLKNKLKDLGHPVEE-EDELE 941
+ + L ++ K+ +L+ L ++ E E EL+
Sbjct: 770 SKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQ 808
Score = 32.7 bits (73), Expect = 1.7
Identities = 24/106 (22%), Positives = 51/106 (48%), Gaps = 10/106 (9%)
Query: 851 SALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTE----KDKLELEITDSKKEQ 906
+AL + KE + I+ L ER + ++ + S + ++ E +D + + + + +
Sbjct: 351 TALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKM 410
Query: 907 DDLLVLLADQDQKILSLKNKLKDLGHPVE------EEDELESGDQE 946
D L ++ D++ + L N+L++ VE EE+ + GD E
Sbjct: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE 456
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 73.2 bits (178), Expect = 1e-12
Identities = 78/406 (19%), Positives = 178/406 (43%), Gaps = 56/406 (13%)
Query: 612 EFTKLVKELEGV---ITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEE 668
E KL ++LE I + + E K + + L+ + +T+ + + E E
Sbjct: 778 EMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET 837
Query: 669 LRQQVSTLKCQNEQ-------LQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQH------- 714
L +++ LK + + +Q ++ + V+++ Q ++Q+N+L L K ++
Sbjct: 838 LEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAK 897
Query: 715 ------------------QGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEK 756
+ +E +M+G ++ ++ +E+ +R+ E LQ +LT+
Sbjct: 898 FREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKA 957
Query: 757 DSMIENMKSSQTSGT--NEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTE 814
+ ++ S T EQS + + E+ EL+++L+ L+ ++ + + +L+
Sbjct: 958 NENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR 1017
Query: 815 KQELLQKTEAFAKSVEVQGETETIIAT--KTTDVEGRLSALLQETKELKNE--------- 863
+ +T+ + + +Q +T++ T K S LLQE +EL+ +
Sbjct: 1018 YERATSETKTKHEEI-LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQT 1076
Query: 864 -------IKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQ 916
++ +++E+T L+ + T A LQ E D L+ + +E + LL +
Sbjct: 1077 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1136
Query: 917 DQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDHI 962
+QK+ + +++ L ++ + S QE+ +E+ G+ D +
Sbjct: 1137 NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1182
Score = 67.8 bits (164), Expect = 5e-11
Identities = 97/383 (25%), Positives = 163/383 (42%), Gaps = 81/383 (21%)
Query: 616 LVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVST 675
L K +E + KA E KK EE KK LE+ + + + ++E Q
Sbjct: 964 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERK----------LSDLEKKMETSHNQCQE 1013
Query: 676 LKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRL 735
LK + E+ + + +I Q NL K L +++ +G+ EE L
Sbjct: 1014 LKARYERATSETKTKHEEILQ-----NLQKTLLDTEDKLKGAR-----------EENSGL 1057
Query: 736 REEIEELKRNQELLQSQLTEKDSM--IENMKSSQTSGTNEQSSAIVSARDSEQV-AELKQ 792
+E+EEL++ + ++ T +D+M +E M T E++ + S D++Q A+L+
Sbjct: 1058 LQELEELRKQADKAKAAQTAEDAMQIMEQM-------TKEKTETLASLEDTKQTNAKLQN 1110
Query: 793 ELATLKSQLNSQSVEITKLQTEKQELL---QKTEAFAKSVEVQGETETIIATKTTDVEGR 849
EL TLK N ++VE +L K+ L QK E F K +E + + + + ++
Sbjct: 1111 ELDTLKEN-NLKNVE--ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE 1167
Query: 850 LSALLQETKELKNEIKA---LSEERTAIKEQL---------------------DSSNSTI 885
L +E ++E+ + L EER+ + QL S S
Sbjct: 1168 NVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISIT 1227
Query: 886 AILQTEKD----KLELEITDSKKEQDDL-----LVLLADQDQKILSLKNKLKDLGHPVEE 936
+ L TEKD KL E+T + E +V + D+ L LK K +L E
Sbjct: 1228 SALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL-QLKEN 1286
Query: 937 EDELESGD-----QEDEDDESED 954
+ +L S Q DED+ +++
Sbjct: 1287 KRQLSSSSGNTDTQADEDERAQE 1309
Score = 60.8 bits (146), Expect = 6e-09
Identities = 75/348 (21%), Positives = 153/348 (43%), Gaps = 38/348 (10%)
Query: 610 DHEFTKLVKELEGV---ITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQL 666
+ +F L +LE + + K E+D++EE++ K E+ +N + M + QL
Sbjct: 874 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQL 933
Query: 667 EELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNG 726
++ ++ + E+LQ +T K N +Q K + +E +Q
Sbjct: 934 TKMNDELRLKERDVEELQLKLT---------KANENASFLQ--KSIEDMTVKAEQSQQEA 982
Query: 727 IQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQ 786
+ E EE +EL+R L+ ++ + + +K+ T+E + + E
Sbjct: 983 AKKHE-----EEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT-----KHEEI 1032
Query: 787 VAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDV 846
+ L++ L + +L E + L E +EL ++ + AK+ + + I+ T +
Sbjct: 1033 LQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK-AKAAQTAEDAMQIMEQMTKEK 1091
Query: 847 EGRLSALLQETKE----LKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDS 902
L++L ++TK+ L+NE+ L E E+L+ S +L E K+E +
Sbjct: 1092 TETLASL-EDTKQTNAKLQNELDTLKENNLKNVEELNKSKE---LLTVENQKME----EF 1143
Query: 903 KKEQDDLLVLLADQDQKILSLKNKLKDLGHPV-EEEDELESGDQEDED 949
+KE + L A + Q++ +L+ + L + DE+ S + +E+
Sbjct: 1144 RKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEE 1191
Score = 51.2 bits (121), Expect = 5e-06
Identities = 67/294 (22%), Positives = 132/294 (44%), Gaps = 40/294 (13%)
Query: 561 KEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKEL 620
++KLK E+ G +++L + K ++A+Q + E M E T+ + L
Sbjct: 1044 EDKLKGAREENSG---LLQELEELRKQADKAKAAQTAEDAMQIMEQMT--KEKTETLASL 1098
Query: 621 EGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQN 680
E +E D +E K +E+ + K ++ ++ ++EE R+++ TLK
Sbjct: 1099 EDTKQTNAKLQNELDTLKENNLKNVEE----LNKSKELLTVENQKMEEFRKEIETLK--- 1151
Query: 681 EQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLR---- 736
Q +QQ+S +Q+ + L +LG+ S+ + + + ++ ++
Sbjct: 1152 -QAAAQKSQQLSALQEENVK---LAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRES 1207
Query: 737 -------EEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSA-----IVSARDS 784
EE L+++ + + LTEKD+ +E +++ T E +SA +V +S
Sbjct: 1208 KFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLES 1267
Query: 785 E------QVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEA-FAKSVEV 831
+ +V L+ +L K QL+S S T Q ++ E Q+++ F SV V
Sbjct: 1268 DKVKLELKVKNLELQLKENKRQLSSSSGN-TDTQADEDERAQESQIDFLNSVIV 1320
Score = 46.2 bits (108), Expect = 1e-04
Identities = 76/427 (17%), Positives = 174/427 (40%), Gaps = 19/427 (4%)
Query: 525 QIAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKE-KLKQLIEKRIGKENFIEKLGF 583
++ L EE++ V+ L + SI D ++ ++ ++K+L + + ++ +KL
Sbjct: 426 ELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKADKLQR 485
Query: 584 ISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELE-----GVITKAIYKSSEEDKKE 638
+ + S+K + + + E +L + LE G + ++ E +
Sbjct: 486 ELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQ 545
Query: 639 EEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHK 698
E+++ T H +T K ++ E ++++ L E+L S+++ H
Sbjct: 546 EKLEVTRTDHQREITSLKEHFGARE---ETHQKEIKALYTATEKLSKENESLKSKLE-HA 601
Query: 699 DQYNLLKIQLGKDNQHQGSYSEGAQMNGIQ---PEEIGRLREEIEELKRNQELLQSQLTE 755
++ N I L K S M ++ + +G E ELK E ++
Sbjct: 602 NKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQH 661
Query: 756 KDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEK 815
+ ++N + S+ + ++ A+ A+ + + E + L ++S+L+ + +
Sbjct: 662 EIENLQNQQDSERAAHAKEMEAL-RAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT 720
Query: 816 QELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIK 875
LQ+ E K +EV + T V ++ L+ T+E ++ AL + + K
Sbjct: 721 LNKLQEAEIKVKELEVLQAK----CNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGK 776
Query: 876 EQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVE 935
++ + + + LE+E + + L ++ K+ +L+ L ++ E
Sbjct: 777 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 836
Query: 936 E-EDELE 941
E EL+
Sbjct: 837 TLEKELQ 843
Score = 43.5 bits (101), Expect = 0.001
Identities = 68/333 (20%), Positives = 146/333 (43%), Gaps = 38/333 (11%)
Query: 633 EEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVS 692
E + K ++++ +E D N + E+ ++E+L+ +V L+T + +
Sbjct: 405 ELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHA 464
Query: 693 QIQQHK-----DQYNLLKIQLGKDNQHQGSYSEGAQMN------GIQPEEIGRLREEIEE 741
+I++ + ++ K+Q ++ + SE +++ ++ +E+ LR +E
Sbjct: 465 RIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLES 524
Query: 742 LK--RNQELLQSQLTEKDSMIENMKSSQTSGTNEQSS--AIVSARDSEQVAELK------ 791
K + ++ S L E S+ E ++ ++T E +S AR+ E+K
Sbjct: 525 NKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTAT 584
Query: 792 ----QELATLKSQL---NSQSVEI-----TKLQTEKQELLQKTEAFAKSVEVQGETETI- 838
+E +LKS+L N ++ ++ +KL+T Q E S TET
Sbjct: 585 EKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAE 644
Query: 839 IATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTI-AILQTEKDKLEL 897
A T +E E + L+N+ ER A +++++ + + +++ +++ LE
Sbjct: 645 FAELKTQIEKMRLDYQHEIENLQNQ---QDSERAAHAKEMEALRAKLMKVIKEKENSLEA 701
Query: 898 EITDSKKEQDDLLVLLADQDQKILSLKNKLKDL 930
+ K +D LV + D K+ + K+K+L
Sbjct: 702 IRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKEL 734
Score = 33.1 bits (74), Expect = 1.3
Identities = 24/108 (22%), Positives = 52/108 (48%), Gaps = 10/108 (9%)
Query: 851 SALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTE----KDKLELEITDSKKEQ 906
+AL + KE + I+ L ER + ++ + S + ++ E +D + + + + +
Sbjct: 351 TALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKM 410
Query: 907 DDLLVLLADQDQKILSLKNKLKDLGHPVE------EEDELESGDQEDE 948
D L ++ D++ + L N+L++ VE EE+ + GD E +
Sbjct: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQ 458
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 72.0 bits (175), Expect = 2e-12
Identities = 80/368 (21%), Positives = 165/368 (44%), Gaps = 40/368 (10%)
Query: 619 ELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKC 678
ELE + ++ + K +E +K L++ +++ +I E + + L
Sbjct: 685 ELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSE 744
Query: 679 QNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGK-DNQHQGSYSEGAQMNGIQPEEIGRLRE 737
+ +QL + V +++S + + + Q L++ L + + Q + Y + + E+I L
Sbjct: 745 ERDQLLSQV-KELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSI 803
Query: 738 E-------IEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAEL 790
E IE L+ + +Q Q +E+ ++I +++S N++S + A E+V +
Sbjct: 804 EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQ---NKESEVLEGA---ERVRHI 857
Query: 791 KQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRL 850
++ L L+ + +EITK+ E + E +++E + + T I+ T+ +L
Sbjct: 858 SSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQL 917
Query: 851 S----ALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAIL-----------QTEKDKL 895
+ +L E K LK ++ LS A KEQ++ N + L Q K++L
Sbjct: 918 NEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEEL 977
Query: 896 ELEITDSKKEQDD-------LLVLLADQDQKILSLKNKLKDLGHPVEEE---DELESGDQ 945
+ E KKE + L+ + Q++ L+ +L +L ++E E E G+
Sbjct: 978 QHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEV 1037
Query: 946 EDEDDESE 953
E++ + E
Sbjct: 1038 EEDKENKE 1045
Score = 67.0 bits (162), Expect = 8e-11
Identities = 89/358 (24%), Positives = 163/358 (45%), Gaps = 50/358 (13%)
Query: 615 KLVKELEGVITKAIYKSSEEDKKEEEVKK----TLEQHDNI------VTHYKNMIREQDL 664
KLVKE+E + + I +S+E +K +E++K L+ ++N+ + H +R++
Sbjct: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQ 1644
Query: 665 QL-EELRQQVSTLKCQNEQLQTAVTQQVSQIQQ------HKDQYNLLKIQLGKDNQHQGS 717
+L +LR + K +QLQ A Q++ ++++ Q +L+++ D
Sbjct: 1645 ELYGKLRSTEANKKETEKQLQEA-EQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEV 1703
Query: 718 YSEG----------AQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQ 767
+ G N EE+ R++ E E L + QS ++EKDS+ S +
Sbjct: 1704 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKK---FQSLMSEKDSL-----SEE 1755
Query: 768 TSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAK 827
Q VS + + + E K + T ++ +QS+ +TE+Q+ L +
Sbjct: 1756 VQDLKHQIEGNVSKQANLEATE-KHDNQTNVTEEGTQSI---PGETEEQDSLSMSTRPTC 1811
Query: 828 SVEV-QGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKE---QLDSSNS 883
S V ++ +K ++ LQ+ +LK I L EE+ KE L++ +
Sbjct: 1812 SESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKN 1871
Query: 884 TIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELE 941
T+ + KD EL++ +E+ + LL Q Q+ LS KLK+ EE+D+LE
Sbjct: 1872 TLLSQISTKDG-ELKML---QEEVTKMNLLNQQIQEELSRVTKLKETAE--EEKDDLE 1923
Score = 64.3 bits (155), Expect = 5e-10
Identities = 95/423 (22%), Positives = 182/423 (43%), Gaps = 47/423 (11%)
Query: 562 EKLKQLIE--KRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKE 619
+K QL+E K I KEN +K S + S +S + + +Y + ++ E
Sbjct: 2436 DKTNQLMETLKTIKKENIQQKAQLDSF--VKSMSSLQNDRDRIVGDYQQLEERHLSIILE 2493
Query: 620 LEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQ 679
+ +I +A ++E +K +EE++ D++ + + E E+L Q ++ Q
Sbjct: 2494 KDQLIQEA---AAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQ 2550
Query: 680 NEQLQTAVTQQVSQIQQHKDQYN-LLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREE 738
+QL Q+QQ+K+ N K++ + + N +Q EE L +E
Sbjct: 2551 QKQLLEV------QLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQ-EEKQDLSKE 2603
Query: 739 IEELKRNQELLQSQLTE-KDSMIENMKSSQTSGTNEQSSAIVSARDSEQ--VAELKQELA 795
IE LK + L Q+T ++ + +Q E+ + + S Q +AEL++EL
Sbjct: 2604 IESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELV 2663
Query: 796 TLKSQLNSQSVEIT-KLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALL 854
++ + + EI KL+ E + L E E +A ++E +L +
Sbjct: 2664 CVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVT 2723
Query: 855 QETKELKNEIKAL--------------SEERTAIKEQLDSSNSTIA------ILQTEKDK 894
+E K L +I++ +EE +K + D+S +A +L E+D
Sbjct: 2724 KENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDA 2783
Query: 895 L--ELEITDSKKEQDDLLVL------LADQDQKILSLKNKLKDLGHPVEEEDELESGDQE 946
L E + + E++ L L L +D+++L L ++L+D + V+ + + Q
Sbjct: 2784 LLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQN 2843
Query: 947 DED 949
+ D
Sbjct: 2844 ERD 2846
Score = 61.2 bits (147), Expect = 4e-09
Identities = 90/387 (23%), Positives = 172/387 (44%), Gaps = 59/387 (15%)
Query: 618 KELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEE----LRQQV 673
KELE ITK E+ + E +++T+E+ D VT + E+ +QL E L ++
Sbjct: 871 KELE--ITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEI 928
Query: 674 STLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQ---------------------LGKDN 712
TLK Q L A + Q+++ + + LK L K+N
Sbjct: 929 KTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKEN 988
Query: 713 QHQGSYSEGAQMNGIQ-PEEIGRLREEI----EELKRNQELLQSQLTEKDSMIENMKSSQ 767
+ + + A +N + + + RL EE+ +E K+ L +++ E + EN + S+
Sbjct: 989 EQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSE 1048
Query: 768 TSGTN--EQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAF 825
T+ ++ + SE+ EL+ L+ +L ++ ++ Q L KT
Sbjct: 1049 KCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQI 1108
Query: 826 ----AKSVEVQGETETIIATKTTDVEGRLSALLQET---------------KELKNEIKA 866
A+ E Q + +I + T +G AL++ET EL+ +I A
Sbjct: 1109 DLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILA 1168
Query: 867 LSEERTAIKEQL-DSSNSTIAILQTEKDK---LELEITDSKKEQDDLLVLLADQDQKILS 922
L +E+ ++++L ++ S AIL+ ++K L E+ K + + L +Q ++ +
Sbjct: 1169 LEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENEN 1228
Query: 923 LKNKLKDLGHPVEE--EDELESGDQED 947
+ ++L+ L V E + +L S DQ++
Sbjct: 1229 IGDQLRQLQIQVRESIDGKLPSTDQQE 1255
Score = 60.1 bits (144), Expect = 1e-08
Identities = 61/333 (18%), Positives = 160/333 (48%), Gaps = 41/333 (12%)
Query: 638 EEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQH 697
+E+V++ L + +V K++IR++D+QL++ + + ++ + A ++ +++ H
Sbjct: 47 QEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEAL-------QEERKAADNKIKKLKLH 99
Query: 698 KDQYNLLKIQLGKDNQH-QGSYSEGAQMNGIQP---EEIGRLREEIEELKRNQELLQSQL 753
K +L N++ + ++G + +P E++ + + E + E ++ +L
Sbjct: 100 ------AKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKL 153
Query: 754 TEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQEL-------ATLKSQLNSQSV 806
EK+ +I +++ T EQ + S+ + E+ +KQ+L +TL++QL+
Sbjct: 154 QEKEELISTLQAQLTQAQAEQPAQ--SSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQA 211
Query: 807 EITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKT---TDVEGRLSALLQETKELKNE 863
E Q +Q + +K F V + + + T+ T+++ +L L ++ +E +
Sbjct: 212 E----QAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEES 267
Query: 864 IKALSEERTAIKEQLDSSNSTIAILQTEKDKLELE------ITDSKKEQDDLLV--LLAD 915
+ ++ ++++L ++ IL + ++E E ++++E+ +L+ + +
Sbjct: 268 LVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELE 327
Query: 916 QDQKILSLKNKLKDLGHPVEEEDELESGDQEDE 948
++ LS N +++ H +E+ ++ E E
Sbjct: 328 VAERKLSFHNLQEEMHHLLEQFEQAGQAQAELE 360
Score = 58.9 bits (141), Expect = 2e-08
Identities = 70/336 (20%), Positives = 149/336 (44%), Gaps = 28/336 (8%)
Query: 615 KLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVS 674
+LV EL+ +I + K + +K+E +++ + DN + K + +L L + +
Sbjct: 59 QLVVELKDIIRQ---KDVQLQQKDEALQEERKAADNKI---KKLKLHAKAKLTSLNKYIE 112
Query: 675 TLKCQNEQLQTAVTQQVSQIQQH-----KDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQP 729
+K Q + Q Q+ +H +++ + KI+ + + + AQ+ Q
Sbjct: 113 EMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQA 172
Query: 730 EEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIV----SARDSE 785
E+ + E+EE +++ QL EK+ I +++ + EQ++ V AR
Sbjct: 173 EQPAQSSTEMEEF----VMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFET 228
Query: 786 QVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTD 845
QV + EL L +Q + + T++Q + + L +K E +S+ + + ++ + T
Sbjct: 229 QVRLHEDELLQLVTQADVE----TEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTA 284
Query: 846 VEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKE 905
E R L Q+ ++++ E L R ++ + + S + ++ E + +L + ++E
Sbjct: 285 AEQRNQILSQQLQQMEAEHNTL---RNTVETEREESKILLEKMELEVAERKLSFHNLQEE 341
Query: 906 QDDLLVLL--ADQDQKILSLKNKLKDLGHPVEEEDE 939
LL A Q Q L + + H E E++
Sbjct: 342 MHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEK 377
Score = 57.8 bits (138), Expect = 5e-08
Identities = 88/384 (22%), Positives = 172/384 (44%), Gaps = 47/384 (12%)
Query: 560 MKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKE 619
+KE++ L E++ + F + L K+ L S+ S K E + E TK+
Sbjct: 1845 LKERIAGLEEEKQKNKEFSQTLEN-EKNTLLSQISTK------DGELKMLQEEVTKM--- 1894
Query: 620 LEGVITKAIYKSSEEDKKEEEVKKTLEQH-DNIVTHYKNMIREQDLQLEELRQQVSTLKC 678
++ + I EE + ++K+T E+ D++ N + E + + Q V+ +
Sbjct: 1895 --NLLNQQI---QEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQI 1949
Query: 679 QNEQLQTAVTQQ---VSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRL 735
+NE L++ + VS++++ K Q L+K + +++ + Y E Q +P
Sbjct: 1950 KNELLESEMKNLKKCVSELEEEKQQ--LVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHA 2007
Query: 736 REEIEELK-RNQELLQSQ-----LTEKDSMIEN-MKSSQTSGTNEQSSAIVSARDSEQVA 788
+E E LK + QE+ Q Q EK S +E +K+ + T Q ++ + Q
Sbjct: 2008 KELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAV 2067
Query: 789 ELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETI---IATKTTD 845
E +++ +++L S V + Q+E +L K E+Q E++ + K D
Sbjct: 2068 EHRKKA---QAELASFKVLLDDTQSEAARVLADNLKLKK--ELQSNKESVKSQMKQKDED 2122
Query: 846 VEGRLSAL----LQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITD 901
+E RL L+E K ++ ++ AL E+ ++E TI +Q +K + E+
Sbjct: 2123 LERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEE-------TIGEIQVTLNKKDKEVQQ 2175
Query: 902 SKKEQDDLLVLLADQDQKILSLKN 925
++ D + LA + + SL++
Sbjct: 2176 LQENLDSTVTQLAAFTKSMSSLQD 2199
Score = 57.8 bits (138), Expect = 5e-08
Identities = 78/385 (20%), Positives = 156/385 (40%), Gaps = 56/385 (14%)
Query: 617 VKELEGVITKAIYKSSEED--KKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVS 674
VKE E A++ SS++ + EEE+ ++ V ++ ++++ L+ L
Sbjct: 2636 VKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKE---LKHLHHDAG 2692
Query: 675 TLKCQNEQLQTAVTQQVSQIQQHKDQYNLL-KIQLGKDNQHQGSYSEGAQMNGIQPEEIG 733
++ + E + V + + + + + ++ K G Q Q S G M+ +Q
Sbjct: 2693 IMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQ---SFGRSMSSLQNSR-D 2748
Query: 734 RLREEIEELKRNQELLQSQLT----------EKDSMIENMKSSQTSGTNEQSSAIVSARD 783
EE++ELKR + +L E+D+++ S S S +
Sbjct: 2749 HANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQ 2808
Query: 784 S-----EQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETI 838
EQ+ L +L +Q+ S S + LQ E+ L + E F KS E + +
Sbjct: 2809 QLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQ 2868
Query: 839 IATKTTDVEG---RLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKL 895
+T +V+ +S+L + L E+K L ++ I +++ + A LQ +DK
Sbjct: 2869 PSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKT 2928
Query: 896 E-LEITDSKKEQDDL---------------------------LVLLADQDQKILSLKNKL 927
+ +I + Q++L L+ ++D+DQ++ L+N +
Sbjct: 2929 KAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLI 2988
Query: 928 KDLGHPVEEEDELESGDQEDEDDES 952
++L + L+ Q E+
Sbjct: 2989 RELRSSSSQTQPLKVQYQRQASPET 3013
Score = 55.1 bits (131), Expect = 3e-07
Identities = 83/341 (24%), Positives = 146/341 (42%), Gaps = 66/341 (19%)
Query: 612 EFTKLVKELEGVITKAIYKSSEED--KKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEEL 669
E +L+ +LE T+ +Y SS+ + K E E+K +Q ++ + +EQ LE +
Sbjct: 2285 ENKELLSQLEE--TRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC-KEQKGNLEGI 2341
Query: 670 -RQQ---VSTLKCQNEQLQT------AVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYS 719
RQQ + K EQL+T +T ++ + K+Q ++ + GK+ Q + +
Sbjct: 2342 IRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQ-KIISLLSGKEEAIQVAIA 2400
Query: 720 EGAQMNGIQPEEIGRLREEIEE------------LKRNQELLQSQLTEK----------D 757
E Q + + +E+ L + EE + + +L+++ T K D
Sbjct: 2401 ELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLD 2460
Query: 758 SMIENMKSSQTSGTN---------EQSSAIVSARDS---EQVAE---LKQELATLKSQLN 802
S +++M S Q E+ +I+ +D E AE LK+E+ L+S ++
Sbjct: 2461 SFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMD 2520
Query: 803 SQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKN 862
+ E KL E L+Q E + +I K + + L LQ+ KEL+N
Sbjct: 2521 DLNSENAKLDAE---LIQYRE----------DLNQVITIKDSQQKQLLEVQLQQNKELEN 2567
Query: 863 EIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSK 903
+ L E+ +E + + LQ EK L EI K
Sbjct: 2568 KYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLK 2608
Score = 54.7 bits (130), Expect = 4e-07
Identities = 62/329 (18%), Positives = 143/329 (43%), Gaps = 33/329 (10%)
Query: 631 SSEEDKKEEEVKKTLEQHDNI---VTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAV 687
+SE KK EEV + EQ + + K + E ++ E L+Q K ++ QLQ A
Sbjct: 1329 TSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQ-----KLESSQLQIAG 1383
Query: 688 TQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQE 747
+ + ++Q D+ L K+ K+ E++ L ++ E +
Sbjct: 1384 LEHLRELQPKLDE--LQKLISKKE------------------EDVSYLSGQLSEKEAALT 1423
Query: 748 LLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVE 807
+Q+++ E++ +I+ + + E I + ++ E+KQ+ + + ++
Sbjct: 1424 KIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQ--VELCEMKQKPEEIGEESRAKQQI 1481
Query: 808 ITKLQT---EKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEI 864
KLQ ++E L++ ++ + + + T + DVE ++SA +E + +
Sbjct: 1482 QRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRL 1541
Query: 865 KALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLK 924
L EER + ++D S L + + L+L + ++++ L+ + ++
Sbjct: 1542 ALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAES 1601
Query: 925 NKLKDLGHPVEEEDELESGDQEDEDDESE 953
+ ++ +++E E+ E+ +E+E
Sbjct: 1602 TEWQEKHKELQKEYEILLQSYENVSNEAE 1630
Score = 49.3 bits (116), Expect = 2e-05
Identities = 103/468 (22%), Positives = 178/468 (38%), Gaps = 72/468 (15%)
Query: 557 ESYMKEKLKQLIEKRIG-KENFIEK--LGFISKHELYSR----ASQKPQPNFPSPEYMIF 609
E KE++++ E G K+N+ E G ISK EL + Q +I
Sbjct: 942 EEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALIN 1001
Query: 610 DHEFTKLVKELEGVIT-------KAIYKSSEEDKKEEEVKKTLEQHDNIVT--------H 654
E + V LE + K I S E + EE K+ E + VT +
Sbjct: 1002 RKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIY 1061
Query: 655 YKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGK---- 710
K I E++++L+ +R+ + EQ Q V Q +Q +Q +LL+ ++ +
Sbjct: 1062 LKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAI 1121
Query: 711 ---------DNQHQGSYSEGAQMNGIQPEEIG-------RLREEIEELKRNQELLQSQLT 754
D S + + I P G L E+I L++ +E LQ +L
Sbjct: 1122 IQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQ 1181
Query: 755 EKDSMIENMKSSQTSGTNEQSSAIVSARDS-----EQVAELKQELATLKSQLNSQSVEIT 809
E + + + + +D EQ E +E + QL +++
Sbjct: 1182 EALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVR 1241
Query: 810 KL------QTEKQELLQKT----EAFAKSVE---VQGETETIIATKTTDVEGRLSALLQE 856
+ T++QE T E K+ E Q E+ + SAL
Sbjct: 1242 ESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGG 1301
Query: 857 TK--ELKNEIKALSEERTAIKEQLDSSNSTIAI-------LQTEKDKLELEITDSKKEQD 907
T ++K ++K + E+ ++ ++ S+ S + LQ + +K LEI K
Sbjct: 1302 TSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSH 1361
Query: 908 DLLVLLADQDQKILSLKNKLKDLGHPVEEE---DELESGDQEDEDDES 952
+ V QK+ S + ++ L H E + DEL+ + E+D S
Sbjct: 1362 EAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVS 1409
Score = 48.9 bits (115), Expect = 2e-05
Identities = 112/569 (19%), Positives = 222/569 (39%), Gaps = 94/569 (16%)
Query: 429 LFSTDSLSNWCAAVALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKI 488
L SLS+ C ++ LA L+ KE+L++ I + S + + T + ++
Sbjct: 1559 LLENQSLSSSCESLKLA--LEGLTEDKEKLVK-----EIESLKSSKIAESTEWQEKHKEL 1611
Query: 489 QTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLGIS 548
Q +L+ +SN + H + E + +E+Q
Sbjct: 1612 QKEYEILLQSYENVSNEAERIQH--------------VVEAVRQEKQ------------E 1645
Query: 549 IYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMI 608
+Y S E+ KE KQL E E EK+ +K + + +
Sbjct: 1646 LYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSK--------------QQKILE 1691
Query: 609 FDHEFTKLVKELE--GVITKAIYKS--SEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDL 664
+ E +L E+ G K ++ S +EE+++ +++ + +++++ E+D
Sbjct: 1692 LEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDS 1751
Query: 665 QLEELR-----------QQVSTLKCQNEQLQTAVTQQVSQ-IQQHKDQYNLLKIQL---- 708
EE++ +Q + + QT VT++ +Q I ++ + L +
Sbjct: 1752 LSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTC 1811
Query: 709 GKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQT 768
+ S + + +EI ++I++LK L+ E K+ +
Sbjct: 1812 SESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEE---------EKQKNKEF 1862
Query: 769 SGTNEQSSAIVSARDSEQVAELK--QELATLKSQLNSQSVE----ITKLQTEKQELLQKT 822
S T E + ++ S + ELK QE T + LN Q E +TKL+ +E +K
Sbjct: 1863 SQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEE--EKD 1920
Query: 823 EAFAKSVEVQGETETIIAT---KTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLD 879
+ + + E I TD + + L E K LK + L EE+ + ++
Sbjct: 1921 DLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKT 1980
Query: 880 SSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSL-------KNKLKDLGH 932
S I EK + + +K +L LL ++ Q++ L + K+ L
Sbjct: 1981 KVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALER 2040
Query: 933 PVEEEDELESGDQEDEDDESEDPGKDLDH 961
V+ + +++ Q+D + E+ + ++H
Sbjct: 2041 TVKALEFVQTESQKDLEITKENLAQAVEH 2069
Score = 42.7 bits (99), Expect = 0.002
Identities = 72/366 (19%), Positives = 157/366 (42%), Gaps = 54/366 (14%)
Query: 629 YKSSEEDKKEEEVKKT-----LEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQN-EQ 682
Y + E+ K E +KT L++ + + +++Q+ +L + + + + Q +Q
Sbjct: 363 YSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQ 422
Query: 683 LQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLRE----- 737
L+ + Q+ +I Q ++ L + + Y+EG Q + E I L++
Sbjct: 423 LEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQ--AVTEENIASLQKRVVEL 480
Query: 738 ------------EIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSE 785
E+EELK E L SQ+T ++ +N +E S ++ + S
Sbjct: 481 ENEKGALLLSSIELEELKAENEKLSSQITLLEA--QNRTGEADREVSEISIVDIANKRSS 538
Query: 786 QVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQG------ETETII 839
E Q++ L++ + + E++ L E +E Q+ AF K +++QG + E +
Sbjct: 539 SAEESGQDV--LENTFSQKHKELSVLLLEMKE-AQEEIAFLK-LQLQGKRAEEADHEVLD 594
Query: 840 ATKTTDVEG------RLSALLQETKE----LKNEIKALSEERTAIKEQLDSSNSTIAILQ 889
+ +EG ++ L++T + + NE +L KEQ + + + +
Sbjct: 595 QKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLP---AVEKEQASTEHQSRTSEE 651
Query: 890 TEKDKLELEITDSKKEQDDLLVLLADQDQ----KILSLKNKLKDLGHPVEEEDELESGDQ 945
+ +E+ +K++ D L + D Q ++ LK+++ +L + E+ +
Sbjct: 652 ISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNL 711
Query: 946 EDEDDE 951
+++ E
Sbjct: 712 DEKAKE 717
Score = 41.2 bits (95), Expect = 0.005
Identities = 85/387 (21%), Positives = 147/387 (37%), Gaps = 69/387 (17%)
Query: 557 ESYMKEKLKQLIEKRIGKENFIEKLGFISKH--------ELYSRASQKPQPNFPSPEYMI 608
+ +KEK K +E I KE ++EK+ K EL +K Q + I
Sbjct: 1973 QQLVKEKTK--VESEIRKE-YLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCI 2029
Query: 609 FDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIRE------- 661
+ + + LE + + +E K E K+ L Q V H K E
Sbjct: 2030 ---RYQEKISALERTVKALEFVQTESQKDLEITKENLAQ---AVEHRKKAQAELASFKVL 2083
Query: 662 -QDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSE 720
D Q E R LK + E LQ+ SQ++Q KD+ +++ ++ + +
Sbjct: 2084 LDDTQSEAARVLADNLKLKKE-LQSNKESVKSQMKQ-KDEDLERRLEQAEEKHLKEKKNM 2141
Query: 721 GAQMNGIQPEEIG----------RLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSG 770
+++ ++ E++ L ++ +E+++ QE L S +T+ + ++M S Q
Sbjct: 2142 QEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDR 2201
Query: 771 TNEQSSAIVSARDSEQVAELKQE--------LATLKSQLNSQSVEITKLQTEKQELLQKT 822
A R + K+E + LK QL S+ + +L+ L
Sbjct: 2202 DRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDK 2261
Query: 823 EAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSN 882
+ + E + +TE + K D L E KEL + QL+ +
Sbjct: 2262 QIW----ESKAQTEVQLQQKVCDT------LQGENKELLS--------------QLEETR 2297
Query: 883 STIAILQTEKDKLELEITDSKKEQDDL 909
Q E KLE E+ K + DL
Sbjct: 2298 HLYHSSQNELAKLESELKSLKDQLTDL 2324
Score = 31.2 bits (69), Expect = 4.9
Identities = 62/371 (16%), Positives = 150/371 (40%), Gaps = 37/371 (9%)
Query: 560 MKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKE 619
M++KL + ++ G I+ G S +S + + + E ++ +KE
Sbjct: 2715 MEQKLLMVTKENKGLTAQIQSFG-------RSMSSLQNSRDHANEELDELKRKYDASLKE 2767
Query: 620 LEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQ 679
L + + + + E +N ++H + + ++ + E+L S L+
Sbjct: 2768 LAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDS 2827
Query: 680 NEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEI 739
Q+Q+ ++ ++ +Q +D L +L K + + A P E+ L++ +
Sbjct: 2828 YNQVQS-FSKAMASLQNERDH---LWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAM 2883
Query: 740 EELKRNQELLQSQLT--EKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVA--ELKQELA 795
L+ +++ L +L ++ + N + ++ Q + Q+ EL+QE
Sbjct: 2884 SSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENL 2943
Query: 796 TLKSQLNS-----QSVEITKLQTEKQELLQKTEAFAKSVEVQG----------ETETIIA 840
+ + +L+ S EI + + ++Q L+ ++ + +Q +T+ +
Sbjct: 2944 SWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKV 3003
Query: 841 TKTTDVEGRLSA-------LLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKD 893
SA L+ ET+ L+ ++ +E + ++ NS + L EK+
Sbjct: 3004 QYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKN 3063
Query: 894 KLELEITDSKK 904
L +++ D+ +
Sbjct: 3064 TLSIQLCDTSQ 3074
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 71.2 bits (173), Expect = 4e-12
Identities = 50/298 (16%), Positives = 142/298 (47%), Gaps = 9/298 (3%)
Query: 617 VKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTL 676
V+E EG + + + E++ + E + + + + V + +REQ+ Q+ E Q+
Sbjct: 138 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQ 197
Query: 677 KCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQ-PEEIGRL 735
+ Q + + + +Q Q+Q+ ++Q + Q+ K + G E Q Q ++ ++
Sbjct: 198 EGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQM 257
Query: 736 REEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELA 795
R++ E+++ +E ++ Q E+ + + ++ Q T EQ + EQ+ E ++++
Sbjct: 258 RKQEEQMREQEEQMREQ--EEQMLKQKEQTEQEEQTGEQEEQM--REQEEQMREQEEQMR 313
Query: 796 TLKSQLNSQSVEITK----LQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLS 851
+ Q+ Q ++ K + +K+++ ++ E K E GE E + + V +
Sbjct: 314 EQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE 373
Query: 852 ALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDL 909
+ ++ ++++ + + + ++ + EQ + ++ +++++ + +K+++ +
Sbjct: 374 QMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHM 431
Score = 58.9 bits (141), Expect = 2e-08
Identities = 38/255 (14%), Positives = 123/255 (48%), Gaps = 6/255 (2%)
Query: 617 VKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTL 676
V+E EG + + + E++++ E ++ +++ + + + +R+Q+ Q+ E +QV
Sbjct: 187 VREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQ 246
Query: 677 KCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLR 736
+ Q ++ + + +Q Q+++ ++Q + Q+ K + + + E+ ++R
Sbjct: 247 EEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMR 306
Query: 737 EEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELAT 796
E+ E+++ +E ++ Q + E M + ++ + EQ+ E ++++
Sbjct: 307 EQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQ---MWKQEEQMGEQEEQMQK 363
Query: 797 LKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQE 856
+ Q+ Q ++ K +++++ ++ E K E GE + + + + + + ++
Sbjct: 364 QEEQVRKQEEQMRK---QEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQ 420
Query: 857 TKELKNEIKALSEER 871
++++ + + + E++
Sbjct: 421 KEQMRKQEEHMGEQK 435
Score = 52.4 bits (124), Expect = 2e-06
Identities = 61/353 (17%), Positives = 156/353 (44%), Gaps = 59/353 (16%)
Query: 608 IFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLE 667
I + E + EL+ + + SE +E+K+ LE D I + +REQ+ Q+
Sbjct: 4 ITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLET-DKIPLPQEGQVREQEGQVR 62
Query: 668 ELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGI 727
E QV + Q + + V +Q Q+++ + Q ++ Q G+ + +G E G
Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQ---VREQEGQVREQEGQVRE---QEGQ 116
Query: 728 QPEEIGRLREEIEELKRNQELL---QSQLTEKDSMI---ENMKSSQTSGTNEQSSAIVSA 781
E+ G++RE+ +++ + + + Q+ E++ + E Q EQ +
Sbjct: 117 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV--- 173
Query: 782 RDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIAT 841
EQ +++++ ++ Q + ++ +++++ ++ E K E GE E
Sbjct: 174 --REQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQE----- 226
Query: 842 KTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITD 901
++++ + + + E+ +++Q + +Q +++++ +
Sbjct: 227 ----------------EQMRKQEEQMGEQEEQVQKQEEQ-------VQKQEEQMRKQEEQ 263
Query: 902 SKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESED 954
+++++ + +Q++++L K + E+E++ G+QE++ E E+
Sbjct: 264 MREQEEQM----REQEEQMLKQKEQ-------TEQEEQT--GEQEEQMREQEE 303
Score = 32.7 bits (73), Expect = 1.7
Identities = 21/91 (23%), Positives = 44/91 (48%), Gaps = 11/91 (12%)
Query: 630 KSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQ 689
+ + K+EE+V+K EQ + + +R+Q+ Q+ + +Q+ K Q + + + +
Sbjct: 357 QEEQMQKQEEQVRKQEEQ----MRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMRE 412
Query: 690 QVSQIQQHKDQYNLLKIQLGKDNQHQGSYSE 720
Q Q+ + K+ Q+ K +H G E
Sbjct: 413 QEEQMGEQKE-------QMRKQEEHMGEQKE 436
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 70.9 bits (172), Expect = 6e-12
Identities = 79/397 (19%), Positives = 180/397 (45%), Gaps = 60/397 (15%)
Query: 605 EYMIFDHEFTKLVKE---LEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIRE 661
E ++ + + +K +KE +E I + + +EE++K + + K + + +++ + +++
Sbjct: 986 EILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKK 1045
Query: 662 QDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLG-KDNQHQGSYSE 720
+ E+ RQ++ K + + T + Q++++Q D+ LK+QL K+ + QG+ +
Sbjct: 1046 E----EKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE---LKLQLAKKEEELQGALAR 1098
Query: 721 G-----AQMNGIQ-----PEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSG 770
G + N ++ +I L+E+ E K ++ + Q + +E +K
Sbjct: 1099 GDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALK------ 1152
Query: 771 TNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVE 830
T + + +A E + +QE+A LK L ++ + + ++ + A ++E
Sbjct: 1153 TELEDTLDTTAAQQELRTKREQEVAELKKALEEET------KNHEAQIQDMRQRHATALE 1206
Query: 831 VQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSE---ERTAIKEQLDSSNSTIAI 887
E ++E L + KEL E+K L + E +++LD+ +
Sbjct: 1207 ELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHA 1266
Query: 888 LQTEKDKLELEITDS----KKEQDDLLVLLADQDQK-------ILSLKNKLKDLGHPVEE 936
+E D+L +E+ + + E D++ LL + ++K SL+++L+D ++E
Sbjct: 1267 KVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQE 1326
Query: 937 ED-------------ELESGDQEDEDDESEDPGKDLD 960
E E E +++ +E E+ K+L+
Sbjct: 1327 ETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363
Score = 62.8 bits (151), Expect = 2e-09
Identities = 85/376 (22%), Positives = 153/376 (40%), Gaps = 52/376 (13%)
Query: 594 SQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEV---KKTLEQHD- 649
S+K N + E L ELE + + K+E+EV KK LE+
Sbjct: 1129 SEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETK 1188
Query: 650 NIVTHYKNMIREQDLQLEELRQQVST--------------LKCQNEQL--QTAVTQQVSQ 693
N ++M + LEEL +Q+ L+ N++L + V QQV
Sbjct: 1189 NHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKA 1248
Query: 694 IQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQL 753
+HK + ++Q + SEG RLR E+ E LQ++L
Sbjct: 1249 ESEHKRKKLDAQVQ-----ELHAKVSEG-----------DRLRVELAE---KASKLQNEL 1289
Query: 754 TEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQT 813
+++E + + +S +D++ EL QE K L+S+ ++ + +
Sbjct: 1290 DNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ---ELLQEETRQKLNLSSRIRQLEEEKN 1346
Query: 814 EKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTA 873
QE ++ E K++E Q + ++ D + ++ L + L+ K L ++ A
Sbjct: 1347 SLQEQQEEEEEARKNLEKQ---VLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEA 1403
Query: 874 IKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHP 933
+ ++L+ L+ K++L+ E+ DDL V L Q Q +L+ K K
Sbjct: 1404 LSQRLEEKALAYDKLEKTKNRLQQEL-------DDLTVDLDHQRQVASNLEKKQKKFDQL 1456
Query: 934 VEEEDELESGDQEDED 949
+ EE + + E+ D
Sbjct: 1457 LAEEKSISARYAEERD 1472
Score = 59.7 bits (143), Expect = 1e-08
Identities = 85/391 (21%), Positives = 169/391 (43%), Gaps = 72/391 (18%)
Query: 630 KSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEE---LRQQV------------- 673
+ E K+EE+ K E+ + + M R+ LEE L +Q+
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 674 -STLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGK------DNQHQGSYSEGA---- 722
+ L + ++L+ + S++++ +++ +L+ + K D + Q EGA
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKL 969
Query: 723 QMNGIQPE-EIGRLREEIEELK-RNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVS 780
Q+ + E +I ++ EEI L+ +N + ++ + +D + E SSQ + E++ +
Sbjct: 970 QLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE--CSSQLAEEEEKAKNLAK 1027
Query: 781 ARDSEQV------------AELKQELATLKSQLNSQSV----EITKLQTEKQEL---LQK 821
R+ ++V + +QEL K +L+ ++ +I +LQ + EL L K
Sbjct: 1028 IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAK 1087
Query: 822 TEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKE-----------LKNEIKALSEE 870
E + +G+ ET+ V L A + E +E + + + LSEE
Sbjct: 1088 KEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEE 1147
Query: 871 RTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNK---- 926
A+K +L+ + T A Q + K E E+ + KK ++ + + +I ++ +
Sbjct: 1148 LEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE---ETKNHEAQIQDMRQRHATA 1204
Query: 927 LKDLGHPVEE----EDELESGDQEDEDDESE 953
L++L +E+ + LE Q E D E
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235
Score = 53.5 bits (127), Expect = 9e-07
Identities = 69/358 (19%), Positives = 153/358 (42%), Gaps = 29/358 (8%)
Query: 617 VKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTL 676
+K+LE I A E K+ +++ ++ + + + E Q +E +++ +L
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL 1685
Query: 677 KCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPE-EIGRL 735
+ + QLQ + + ++H +Q + +L + + S + E I +L
Sbjct: 1686 EAEILQLQEELASS-ERARRHAEQE---RDELADEITNSASGKSALLDEKRRLEARIAQL 1741
Query: 736 REEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQV----AELK 791
EE+EE + N ELL + + ++ + + + E+S+A S +Q+ ELK
Sbjct: 1742 EEELEEEQSNMELLNDRFRKTTLQVDTLNAELAA---ERSAAQKSDNARQQLERQNKELK 1798
Query: 792 QELATLKSQLNSQ-SVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRL 850
+L L+ + S+ I+ L+ + +L ++ E AK + K ++ ++
Sbjct: 1799 AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858
Query: 851 SALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLL 910
+ + K +++ + +K QL+ + + KL+ E+ D+ + + L
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGL- 1917
Query: 911 VLLADQDQKILSLKNKLKDLGHPV--------EEEDELESGDQEDEDDESEDPGKDLD 960
+++ +LKN+L+ G P+ + LE E DD++E D++
Sbjct: 1918 ------SREVSTLKNRLR-RGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVN 1968
Score = 52.4 bits (124), Expect = 2e-06
Identities = 42/166 (25%), Positives = 78/166 (46%), Gaps = 26/166 (15%)
Query: 782 RDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIAT 841
R E++ +EL +K + E+ +++ + Q+LL++ A+ ++Q ETE +
Sbjct: 849 RQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAE--QLQAETE--LFA 904
Query: 842 KTTDVEGRLSALLQETKE------------------LKNEIKALSEERTAIKEQLDSSNS 883
+ ++ RL+A QE +E L+NE K + ++EQLD
Sbjct: 905 EAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 884 TIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKD 929
LQ EK E +I K+ ++ ++LL DQ+ K + K ++D
Sbjct: 965 ARQKLQLEKVTAEAKI----KKMEEEILLLEDQNSKFIKEKKLMED 1006
Score = 50.4 bits (119), Expect = 8e-06
Identities = 64/316 (20%), Positives = 140/316 (44%), Gaps = 28/316 (8%)
Query: 631 SSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQ 690
+S +KK+++ + L + +I Y E+D E R++ E ++ +
Sbjct: 1443 ASNLEKKQKKFDQLLAEEKSISARYAE---ERDRAEAEAREK--------ETKALSLARA 1491
Query: 691 VSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGR-LREEIEELKRNQELL 749
+ + + K+++ QL D + S + N + E+ R L +++EE++ E L
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 750 QSQL-TEKDSMIE---NMKSSQTS-----GTNEQSSAIVSARDSEQVAELKQELATLKSQ 800
+ +L +D+ + NM++ + T ++ + +QV EL+ EL + Q
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 801 LNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSA-------L 853
K++ + ++L + EA K+ + + + + D + L +
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 854 LQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLL 913
++KE + ++K+L E ++E+L SS + E+D+L EIT+S + LL
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1731
Query: 914 ADQDQKILSLKNKLKD 929
+ +I L+ +L++
Sbjct: 1732 RRLEARIAQLEEELEE 1747
Score = 37.7 bits (86), Expect = 0.052
Identities = 37/172 (21%), Positives = 83/172 (48%), Gaps = 17/172 (9%)
Query: 781 ARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIA 840
A+ +Q++ LK + L + + ++ T+ + LLQ T + E+Q + E ++
Sbjct: 807 AKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTR---QEEELQAKDEELLK 863
Query: 841 TKT--TDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELE 898
K T VEG L +E++ + + L EE+ + EQL + A + + +L +
Sbjct: 864 VKEKQTKVEGEL-------EEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAK 916
Query: 899 ITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDD 950
+ ++ DL + +++++ L+N+ K + +++ +E Q DE++
Sbjct: 917 KQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE-----QLDEEE 963
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 70.9 bits (172), Expect = 6e-12
Identities = 74/292 (25%), Positives = 141/292 (48%), Gaps = 34/292 (11%)
Query: 639 EEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQH- 697
E+ ++ LEQ + H ++ ++EQ L +L +Q+S + + EQ + +QV +++
Sbjct: 812 EQAQEALEQQLPTLRHERSQLQEQ---LAQLSRQLSGREQELEQARREAQRQVEALERAA 868
Query: 698 KDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKD 757
+++ L K G Q + EG ++ EE RLR E E L+ + +Q QL + +
Sbjct: 869 REKEALAKEHAGLAVQLVAAEREGRTLS----EEATRLRLEKEALEGSLFEVQRQLAQLE 924
Query: 758 SMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQE 817
+ E +++ + A++ A+++ L ELA L+ Q+ + T+++
Sbjct: 925 ARREQLEA--------EGQALLLAKET-----LTGELAGLRQQI---------IATQEKA 962
Query: 818 LLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQ 877
L K K V+ + E + + + E L L +E + E++A ER ++ Q
Sbjct: 963 SLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA---ERAQLQSQ 1019
Query: 878 LD-SSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLK 928
L +A L+ EK++L EI ++E+D+ L+L + Q+ LSLK K
Sbjct: 1020 LQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEK 1071
Score = 57.4 bits (137), Expect = 6e-08
Identities = 72/289 (24%), Positives = 138/289 (47%), Gaps = 25/289 (8%)
Query: 662 QDLQLEELRQQVSTLKCQN----EQLQTAVTQQVSQIQQHKD-QYNLLKIQLGKD--NQH 714
QDL L LR+Q+S + + EQLQ + +Q H+D Q + +++ + ++
Sbjct: 546 QDL-LGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSRE 604
Query: 715 QGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQ 774
+ + + Q+ Q EE LR+E E+L+ QE L+ Q +D + E + + G +
Sbjct: 605 KSNLAHSLQVAQQQAEE---LRQEREKLQAAQEELRRQ---RDRLEEEQEDAVQDGARVR 658
Query: 775 SSAIVSARDSEQV----AELKQELATLKSQLNSQSVEITKLQTEKQELLQK-TEAFAKSV 829
S R EQ+ + L +EL ++ L+ +++ LQ EK E+ + T+A A V
Sbjct: 659 RELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRV 718
Query: 830 EVQGETETIIATKTT--DVEGRLSAL----LQETKELKNEIKALSEERTAIKEQLDSSNS 883
E++ + A + + D +LSAL Q+ +L + L EE++A++ + +
Sbjct: 719 ELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQ 778
Query: 884 TIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGH 932
+ + E+++LE + + + L L +Q +L+ +L L H
Sbjct: 779 EATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRH 827
Score = 50.4 bits (119), Expect = 8e-06
Identities = 52/216 (24%), Positives = 102/216 (47%), Gaps = 24/216 (11%)
Query: 727 IQPEEI-GRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSE 785
+ PE + G LRE ++EL+ Q E+D + +QTS N Q + + + RDS
Sbjct: 1502 LDPEAVRGALREFLQELRSAQR-------ERDEL-----RTQTSALNRQLAEMEAERDSA 1549
Query: 786 QVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTD 845
+ + A +S+ +SV+ +L + EL + E+ +S + T +AT
Sbjct: 1550 TSRARQLQKAVAESEEARRSVD-GRLSGVQAELALQEESVRRSERERRATLDQVATLERS 1608
Query: 846 V---EGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDS 902
+ E L A ++ ++K L ++ +KE LD+S S L+ ++ LE E+ S
Sbjct: 1609 LQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEGELQRS 1668
Query: 903 KKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEED 938
+ + L+D++ + +L++++ L V + +
Sbjct: 1669 R-------LGLSDREAQAQALQDRVDSLQRQVADSE 1697
Score = 49.7 bits (117), Expect = 1e-05
Identities = 57/312 (18%), Positives = 136/312 (43%), Gaps = 32/312 (10%)
Query: 618 KELEGVITKAIYKSSEEDKK-EEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTL 676
++L G + K + S E + EE++++ ++ D + +++ RE +L + +S
Sbjct: 546 QDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ-RLRSANELLSRE 604
Query: 677 KCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPE-EIGRL 735
K QQ +++Q +++ + +L + E A +G + E+ R
Sbjct: 605 KSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERS 664
Query: 736 REEIEELKRNQELLQSQLTE------KDSMIENMKSSQTSGTNEQSSAIVSARDSEQVA- 788
++E+L+ + +L +L E + ++ +M ++ + E + + R +++
Sbjct: 665 HRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSM 724
Query: 789 -ELKQELATLKSQLNSQSVEITKLQTEKQEL------LQKTEAFAKSVEVQGETETIIAT 841
+L+ E A+L+ L+ S L +K +L L++ ++ + + Q E E +A
Sbjct: 725 TKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAR 784
Query: 842 KTTD---------------VEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIA 886
+ + +EG L Q + L+ ++ L ER+ ++EQL + ++
Sbjct: 785 EEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLS 844
Query: 887 ILQTEKDKLELE 898
+ E ++ E
Sbjct: 845 GREQELEQARRE 856
Score = 43.5 bits (101), Expect = 0.001
Identities = 66/336 (19%), Positives = 137/336 (40%), Gaps = 43/336 (12%)
Query: 556 LESYMKEKLKQLIEK-RIGKENFIEKLGFISKHE---LYSRASQKPQPNFPSPEYMIFDH 611
L+S ++ + ++L+ + KE E++ + + L S+K Q + +
Sbjct: 1016 LQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQA------LSLKES 1069
Query: 612 EFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQ 671
E T L ++L G S E ++++ + + EQ + V + +R+
Sbjct: 1070 EKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRD---------- 1119
Query: 672 QVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEE 731
L+ Q E+ A Q+V ++Q+ LGK Q E ++ +
Sbjct: 1120 ----LRAQREEAAAAHAQEVRRLQEQARD-------LGK--QRDSCLREAEELR----TQ 1162
Query: 732 IGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELK 791
+ L + + L+R ELL++Q ++S Q +G +S A++ E +
Sbjct: 1163 LRLLEDARDGLRR--ELLEAQRKLRESQEGREVQRQEAGELRRSLG-EGAKEREALRRSN 1219
Query: 792 QELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLS 851
+EL + + S+ + + +K++ L E +V G+ + T +VE
Sbjct: 1220 EELRSAVKKAESERISLKLANEDKEQKLALLEEARTAV---GKEAGELRTGLQEVERSRL 1276
Query: 852 ALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAI 887
+E +EL+ ++K L E T + +L +A+
Sbjct: 1277 EARRELQELRRQMKMLDSENTRLGRELAELQGRLAL 1312
Score = 42.0 bits (97), Expect = 0.003
Identities = 80/409 (19%), Positives = 169/409 (41%), Gaps = 49/409 (11%)
Query: 555 SLESYMKEKLKQLIEKRIGKENFIEKLG---FISKHELYSRASQKPQPNFPSPEYMIFDH 611
+LE + E +QL + +E +E G ++K L + Q + E D
Sbjct: 908 ALEGSLFEVQRQLAQLEARREQ-LEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDK 966
Query: 612 EFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQ 671
E + ++L +A E+ EE + L++ ++ + E+ +L++
Sbjct: 967 EL--MAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAA--WRELEAERAQLQSQLQR 1022
Query: 672 QVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEE 731
+ L + E + ++++++ +QQ +D+ LL + + Q + ++ + +
Sbjct: 1023 EQEELLARLEAEKEELSEEIAALQQERDEGLLL----AESEKQQALSLKESEKTALSEKL 1078
Query: 732 IGRLRE------EIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSE 785
+G E+E KR+ + Q E+D N +S+ Q +A ++
Sbjct: 1079 MGTRHSLATISLEMERQKRDAQSRQ----EQDRSTVNALTSELRDLRAQREEAAAAH-AQ 1133
Query: 786 QVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSV-EVQGETETIIATKTT 844
+V L+++ L Q +S E +L+T+ + L + + + E Q +
Sbjct: 1134 EVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRE------- 1186
Query: 845 DVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKK 904
EGR QE EL+ + ++ER A++ + S A+ + E +++ L++ +
Sbjct: 1187 SQEGR-EVQRQEAGELRRSLGEGAKEREALRRSNEELRS--AVKKAESERISLKLANE-- 1241
Query: 905 EQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESE 953
D++QK+ L+ +G +E EL +G QE E E
Sbjct: 1242 ----------DKEQKLALLEEARTAVG---KEAGELRTGLQEVERSRLE 1277
Score = 39.3 bits (90), Expect = 0.018
Identities = 86/393 (21%), Positives = 166/393 (42%), Gaps = 23/393 (5%)
Query: 529 NLGEEEQLVQGLCAL---LLGISIYFNDNSLESY--MKEKLKQLIEKRIGKENFIEKLGF 583
+L EE QL+Q + LL S D Y + E+L+Q + G+ E G
Sbjct: 78 SLQEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLEQALRLEPGELETQEPRGL 137
Query: 584 ISKHELYSRASQKPQPNFPSP--EYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEV 641
+ + R Q+ Q ++ Y +LV+ L+G I + + SE +++ E
Sbjct: 138 VRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLER 197
Query: 642 KKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQY 701
LEQ T + + ++LEE +Q+ ++L N L+ + Q S Q +
Sbjct: 198 SGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDI 257
Query: 702 NLLK---IQLGKDNQHQGS--YSEGAQMNGIQPEEIGRLREEIEELKRNQELLQ--SQLT 754
+ + K+ +H+ + E N E RL ++ + L+ T
Sbjct: 258 RKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFT 317
Query: 755 EKDSMIENMKSSQTSGTNEQSSAIVSA--RDSEQVAELK-QELATLKSQLNSQSVEITKL 811
E+D + + ++TS +++ +S R +E AE ++ A L++QL Q + K+
Sbjct: 318 ERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQLRD--KV 375
Query: 812 QTEKQELLQKTEAFAKSVEVQGE-TETIIATKTTDVEGRLSALLQETKELKNEIKALSEE 870
EK Q+ ++ ++ TE +A K + + Q K+L +++AL
Sbjct: 376 LREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKD--QVNKDLTEKLEALESL 433
Query: 871 RTAIKEQLDSSNSTIAILQTEKDKLELEITDSK 903
R + L++ + + QT +D + ++DS+
Sbjct: 434 RLQEQAALETEDGE-GLQQTLRDLAQAVLSDSE 465
Score = 32.7 bits (73), Expect = 1.7
Identities = 40/197 (20%), Positives = 80/197 (40%), Gaps = 38/197 (19%)
Query: 742 LKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQ- 800
L+ +LLQ +L+ + ++ +Q+ ++ + +A L+ E L++Q
Sbjct: 79 LQEENQLLQQELSRVEDLL-----AQSRAERDELAIKYNAVSERLEQALRLEPGELETQE 133
Query: 801 ---LNSQSVEITK-LQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQE 856
L QSVE+ + LQ E+ +K +A+ + + Q + + K + R S L Q+
Sbjct: 134 PRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQ 193
Query: 857 TKELKNEIK----------------------------ALSEERTAIKEQLDSSNSTIAIL 888
E E++ +L++ ++EQLD + S L
Sbjct: 194 LLERSGELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQAL 253
Query: 889 QTEKDKLELEITDSKKE 905
+ K+ + T +KE
Sbjct: 254 SEDIRKVTNDWTRCRKE 270
Score = 32.3 bits (72), Expect = 2.2
Identities = 49/238 (20%), Positives = 90/238 (37%), Gaps = 29/238 (12%)
Query: 656 KNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQ 715
+ + E Q L +QV TL+ + L+ + Q+QQ ++ Q
Sbjct: 1774 RQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVL------------RQ 1821
Query: 716 GSYSEGAQMNGIQ--PEEIGRLREEIEELKRNQELLQSQLTEKD-SMIENMKSSQTSGTN 772
E A +N +Q +E L+E + L+R L+++ E + S + K
Sbjct: 1822 RQEGEAAALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRT 1881
Query: 773 EQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKS---- 828
R E L E L L +E+ + Q + Q+L + +S
Sbjct: 1882 LDKVEREKLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPA 1941
Query: 829 -VEVQGETETIIATKTTDVEGRLSALLQETKEL-------KNEIKALSEERTAIKEQL 878
+EV + + + + +VE SA Q + L + ++ L E+ + +K QL
Sbjct: 1942 QLEVDAQQQQLELQQ--EVERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQL 1997
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 70.9 bits (172), Expect = 6e-12
Identities = 76/354 (21%), Positives = 161/354 (45%), Gaps = 31/354 (8%)
Query: 612 EFTKLVKELEGVITKAIY---KSSEEDKKEEEVKKTLEQHDNIVTHYK---NMIREQDLQ 665
E KL +++ + K + K E +E K L++ +T K + IR+
Sbjct: 377 EIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQD 436
Query: 666 LEELRQQVSTLKCQNEQLQTAVT--QQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQ 723
+ + Q+ +K + VT + Q+Q+ DQ + ++ + + ++ EG
Sbjct: 437 MIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMD 496
Query: 724 -----MNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAI 778
++ E RLR E +EL + +E++ Q E ++++ +K++ Q
Sbjct: 497 ELRTLRTKVKCLEDERLRTE-DELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQ---- 551
Query: 779 VSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAF-AKSVEVQGETET 837
R +++ LK+E+ +L S +N +I + + ELL TE +K+ ++Q E+ +
Sbjct: 552 ---RGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNS 608
Query: 838 IIA--TKTTDVEGRLSALLQETKELKNEIKA-LSEERTAIKEQLDSSNSTIAILQTEKDK 894
+ + K + E +L + ++ K+ +++ L +E KE++ + + +A QTE
Sbjct: 609 LQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKA 668
Query: 895 LELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDE 948
L ++ + K E L+ + + S+K+ K L + D++ESG + E
Sbjct: 669 LSTQVEELKDE------LVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKE 716
Score = 60.8 bits (146), Expect = 6e-09
Identities = 85/401 (21%), Positives = 165/401 (41%), Gaps = 69/401 (17%)
Query: 605 EYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKK---TLEQHDNIVTHYKNMIRE 661
+Y+ +H KL+KE + + SE+D EE+KK T +QH N + ++ I E
Sbjct: 201 KYLQQEHIIKKLIKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEE 260
Query: 662 QDLQLEELRQQV----STLKCQNEQLQTAVTQQVSQ-------------------IQQHK 698
+ +++ R Q+ T K +QL + Q++ Q ++ K
Sbjct: 261 LNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEK 320
Query: 699 DQYNLLK---------------IQLGKDNQHQGSYSEGA--QMNGIQPEEIGRLREEIEE 741
+ +L K ++ + Q S +G Q+ + E RL EI++
Sbjct: 321 ESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDK 380
Query: 742 LKRN-----------QELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAEL 790
LK + Q L++++ + +K + T T + A ++ + + +
Sbjct: 381 LKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKT 440
Query: 791 KQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRL 850
QE +KS + +TK + EKQ + +K++ E E + K T EG
Sbjct: 441 YQESEEIKSNELDAKLRVTKGELEKQ-MQEKSDQLEMHHAKIKELEDL---KRTFKEG-- 494
Query: 851 SALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELE-ITDSKKEQDDL 909
+ E + L+ ++K L +ER +++L I + K E++ + D K D L
Sbjct: 495 ---MDELRTLRTKVKCLEDERLRTEDELSKYKEII-----NRQKAEIQNLLDKVKTADQL 546
Query: 910 LVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDD 950
L Q+I +LK +++ L + + + G ++ E +
Sbjct: 547 QEQLQRGKQEIENLKEEVESLNSLINDLQKDIEGSRKRESE 587
Score = 47.0 bits (110), Expect = 9e-05
Identities = 55/242 (22%), Positives = 104/242 (42%), Gaps = 32/242 (13%)
Query: 617 VKELEGVITKAIYKSSEEDKKEEEVK-KTLEQH----DNIVTHYKNMIREQDLQLEELRQ 671
+KELE + K +K ++ + K K LE ++ ++ YK +I Q +++ L
Sbjct: 481 IKELEDL--KRTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLD 538
Query: 672 QVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQM------- 724
+V T EQLQ Q++ +++ + N L L KD + GS +++
Sbjct: 539 KVKTADQLQEQLQRG-KQEIENLKEEVESLNSLINDLQKDIE--GSRKRESELLLFTERL 595
Query: 725 ---NGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAI--- 778
N E L+ + +++ ++ LQSQ + N++S + +
Sbjct: 596 TSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTL 655
Query: 779 ---VSARDSE------QVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSV 829
++ R +E QV ELK EL T + + S ++TK + + L + E+ +
Sbjct: 656 QAELACRQTEVKALSTQVEELKDELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDK 715
Query: 830 EV 831
EV
Sbjct: 716 EV 717
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 68.9 bits (167), Expect = 2e-11
Identities = 77/330 (23%), Positives = 146/330 (44%), Gaps = 51/330 (15%)
Query: 612 EFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQ 671
E+ KL+ E E V TK I + +EE + +K + + + +T+ +N+I+ L ++R
Sbjct: 1353 EYRKLLSEKE-VHTKRIQQLTEEIGR---LKAEIARSNASLTNNQNLIQSLKEDLNKVRT 1408
Query: 672 QVSTLKCQNEQLQTAVTQQVSQIQQ-------HKDQYNLLKIQLGKDNQHQGSYSEGAQM 724
+ T++ + + ++V I Q +K QY LK Q K + S Q
Sbjct: 1409 EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQE 1468
Query: 725 NGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDS 784
+ +E+ L+E + + + + L+SQ+ +++ + + +T N Q
Sbjct: 1469 QHVSVQEMQELKETLNQAETKSKSLESQV---ENLQKTLSEKETEARNLQ---------- 1515
Query: 785 EQVAELKQELATLKSQLNSQSVEITKLQ---TEKQELLQKTEAFAKSVEVQGETETIIAT 841
EQ +L+ EL+ L+ L ++ + +L+ TEK+E +K AKS
Sbjct: 1516 EQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKS------------- 1562
Query: 842 KTTDVEGRLSALLQETKELKNEIKALSEER-------TAIKEQLDSSNSTIAILQTEKDK 894
K + G L +E +ELK AL +++ TA+K Q + S + E +
Sbjct: 1563 KIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITALKSQYEGRISRLERELREHQE 1622
Query: 895 LELEITDSKKEQDDLLVLLADQDQKILSLK 924
LE D +E + + + Q+ ++LK
Sbjct: 1623 RHLEQRDEPQEPSNKV----PEQQRQITLK 1648
Score = 64.3 bits (155), Expect = 5e-10
Identities = 75/340 (22%), Positives = 153/340 (45%), Gaps = 39/340 (11%)
Query: 634 EDKKEEEVKKTLEQHDNIVTHYKNMIRE----QDLQLEELRQQVSTLKCQNEQLQTAV-- 687
E + E K L+Q I +YK E Q+ QLE+L++QV+ L+ QN ++ T +
Sbjct: 661 ESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDF 720
Query: 688 -TQQVSQIQQHKDQYNLLKIQLGKDNQH-QGSYSEGAQMNGIQPEEIGRLREEI------ 739
+++ +Q + + Y L + NQ + + Q+ +++ E++
Sbjct: 721 ASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVR 780
Query: 740 -EELKRNQELLQSQLT----EKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQEL 794
E LK+ +E+L+ +++S++ + TN Q+ + R E KQ L
Sbjct: 781 AENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSE---TETKQRL 837
Query: 795 ATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQG-ETETIIATKTTDVEGRLSAL 853
+ SQ+ EI+ L+ + + +++ ++++VQ +T+ + T+T L
Sbjct: 838 S---SQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETN--------L 886
Query: 854 LQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLL 913
TKEL +K +E +K+ L SN + + + +K++ DDL+ L
Sbjct: 887 HLNTKEL---LKNAQKEIATLKQHL--SNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQL 941
Query: 914 ADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESE 953
++++ LK +LK VE+ + + +E + E +
Sbjct: 942 RQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQ 981
Score = 60.5 bits (145), Expect = 7e-09
Identities = 68/334 (20%), Positives = 157/334 (47%), Gaps = 25/334 (7%)
Query: 636 KKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQ 695
++ +++ T ++ + I+ +R + +L + LK + E L+ +S+++
Sbjct: 744 ERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLK------LSEVR 797
Query: 696 QHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRN----QELLQS 751
+ + +LL Q G++ + + + E RL +IE+L+ ++ L++
Sbjct: 798 LSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLEN 857
Query: 752 QLTEKDSMIENM-------KSSQTSGTNEQSSAIVSARDSE-QVAELKQELATLKSQLNS 803
++ ++ ++ N+ K + TN + ++++ ++A LKQ L+ ++ Q+ S
Sbjct: 858 EVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVAS 917
Query: 804 QSVEIT-KLQTEKQELLQKTEAFAKSVEVQ-GETETIIATKTTDVEGRLSALLQETKELK 861
QS + T K Q +E + + + E Q + + + T T++VE + A++ +E
Sbjct: 918 QSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVE-QYQAMVTSLEESL 976
Query: 862 NEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKE-QDDLLVLLADQDQKI 920
N+ K ++EE +++ ++ A QT+ +K +E+ K+E QDD + +Q++
Sbjct: 977 NKEKQVTEE---VRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQL 1033
Query: 921 LSLKNKLKDLGHPVEEEDELESGDQEDEDDESED 954
LK L + + V+E + S +E D
Sbjct: 1034 SELKKTLSSVQNEVQEALQRASTALSNEQQARRD 1067
Score = 59.3 bits (142), Expect = 2e-08
Identities = 73/356 (20%), Positives = 165/356 (46%), Gaps = 38/356 (10%)
Query: 615 KLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVS 674
+L +E E + ++ + ++E K +E+ + N + K + + ++ L +Q++
Sbjct: 182 RLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMN 241
Query: 675 TLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKD-NQH---QGSYSEGAQMNGIQPE 730
LK NE LQ V ++++++ K+Q ++ + + N H Y A + +
Sbjct: 242 GLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSN 301
Query: 731 EIGRLREEIEELKRN----QELLQSQLTE----KDSMIENM--KSSQTSGTNEQSSAIVS 780
E+ R EE+ +L + + +Q L E KD M + M K + E ++ ++S
Sbjct: 302 ELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS 361
Query: 781 ARDSEQVAELKQELATLK------SQLNSQSVEITKL-----QTEKQELLQKTEAFAKSV 829
A + ++ELA + +++ +++T+L +T+ Q LL+K E +
Sbjct: 362 ATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLE----NK 417
Query: 830 EVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQ 889
+ + I+ +VE + L ++ +E + KA++ ++ +L+ + I LQ
Sbjct: 418 RINKYLDEIV----KEVEAKAPILKRQREEYERAQKAVA----SLSVKLEQAMKEIQRLQ 469
Query: 890 TEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDL-GHPVEEEDELESGD 944
+ DK + + +++ + + + D Q+I L +L++ G+ V ++E+ S D
Sbjct: 470 EDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSAD 525
Score = 55.1 bits (131), Expect = 3e-07
Identities = 73/343 (21%), Positives = 148/343 (43%), Gaps = 35/343 (10%)
Query: 619 ELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKC 678
E++G+ + E +++ E++K L + + + L+LE+L Q+ L
Sbjct: 35 EIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTE 94
Query: 679 QNEQLQTAVTQQV---SQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRL 735
+N++L+ A + + SQ + K++ K L + N+ E E++ RL
Sbjct: 95 KNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELE------YLTEDVKRL 148
Query: 736 REEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELK---- 791
E+++E + LQ +L E + ++K + EQ ++ ++++ ELK
Sbjct: 149 NEKLKESNTTKGELQLKLDELQASDVSVKYREKR--LEQEKELLHSQNTWLNTELKTKTD 206
Query: 792 ----------QELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIAT 841
E+ LK L ++ E+++L+ + L E K VE + T
Sbjct: 207 ELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVED-------LLT 259
Query: 842 KTTDVEGRLSALLQET-KELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEIT 900
K + + + +++ ++ EL IK + ++A + SN ++ E KL E
Sbjct: 260 KLKEAKEQQASMEEKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVE-ELHKLLKEAG 318
Query: 901 DSKKE-QDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELES 942
++ K QD LL + +DQ + K+ L +E ++L S
Sbjct: 319 EANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLS 361
Score = 52.4 bits (124), Expect = 2e-06
Identities = 56/241 (23%), Positives = 111/241 (46%), Gaps = 42/241 (17%)
Query: 736 REEIEELKRN-QELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQEL 794
R E+ +L ++ Q L+ L ++ S I+ +K G +E+ +Q E+++ L
Sbjct: 11 RTELNKLPKSVQNKLEKFLADQQSEIDGLK-----GRHEK----FKVESEQQYFEIEKRL 61
Query: 795 ATLKSQLNSQSVEITKLQTEKQELLQKTEAFA---KSVEVQGETETIIATKTTDVEGRLS 851
+ + +L +++ E L+ E ++L + +A K +E+ + I ++ T + L
Sbjct: 62 SHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELE 121
Query: 852 A----LLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKL------------ 895
A L++ + L E++ L+E+ + E+L SN+T LQ + D+L
Sbjct: 122 AEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREK 181
Query: 896 ----ELEI---------TDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELES 942
E E+ T+ K + D+LL L ++ +IL LK L++ V +E +
Sbjct: 182 RLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMN 241
Query: 943 G 943
G
Sbjct: 242 G 242
Score = 51.2 bits (121), Expect = 5e-06
Identities = 80/395 (20%), Positives = 171/395 (43%), Gaps = 80/395 (20%)
Query: 613 FTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIV--THYKNMIREQDLQLEELR 670
+ + V+ LE + + + E +K + KT+ QH+ ++ T N++ E + L E
Sbjct: 1224 YRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLRE-- 1281
Query: 671 QQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPE 730
+ E+L+ + Q ++++ K + ++L +Q +E ++ +G+
Sbjct: 1282 --------EKERLEQDLQQMQAKVR--KLELDILPLQEAN--------AELSEKSGMLQA 1323
Query: 731 EIGRLREEIEELK-RNQELLQSQL---TEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQ 786
E L E+++ K RNQ L+ Q TE+ + + K T + + I R +
Sbjct: 1324 EKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEI--GRLKAE 1381
Query: 787 VAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTT-- 844
+A L ++ + S ++ K++TEK E +QK + AK +++Q + +TI K
Sbjct: 1382 IARSNASLTNNQNLIQSLKEDLNKVRTEK-ETIQK-DLDAKIIDIQEKVKTITQVKKIGR 1439
Query: 845 -------------DVEGRLSAL-----------LQETKELKNEIKALSEERTAIKEQLDS 880
D SA +QE +ELK + + +++ Q+++
Sbjct: 1440 RYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVEN 1499
Query: 881 SNSTIA--------------ILQTEKDKLELEITDSKKEQDDLLVLLADQDQK----ILS 922
T++ LQ+E +L ++ D +++ L + ++++K I++
Sbjct: 1500 LQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVA 1559
Query: 923 LKNKLKDLG----HPVEEEDELE--SGDQEDEDDE 951
K+K+ L +E +EL+ +G + + DE
Sbjct: 1560 AKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDE 1594
Score = 47.4 bits (111), Expect = 7e-05
Identities = 86/425 (20%), Positives = 174/425 (40%), Gaps = 82/425 (19%)
Query: 611 HEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELR 670
H + ++EL+ + +A KS + + E ++KTL + + + + + +L LR
Sbjct: 1470 HVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLR 1529
Query: 671 QQVSTLKCQNEQLQTAVTQQVSQ----IQQHKDQYNLL---KIQLGKDN----QHQGSYS 719
Q + Q EQL+ +T++ + I K + L K QL K+N Q G+
Sbjct: 1530 QDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALD 1589
Query: 720 E-----GAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIE------------N 762
+ ++ ++ + GR+ EL+ +QE L ++D E
Sbjct: 1590 QQKDELDVRITALKSQYEGRISRLERELREHQE---RHLEQRDEPQEPSNKVPEQQRQIT 1646
Query: 763 MKSSQTSG------------TNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEIT- 809
+K++ SG N + + +VS A + +T ++ + T
Sbjct: 1647 LKTTPASGERGIASTSDPPTANIKPTPVVSTPSKVTAAAMAGNKSTPRASIRPMVTPATV 1706
Query: 810 -------------KLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLS----- 851
Q E QE +Q +E + V V G T + + + +V+ +S
Sbjct: 1707 TNPTTTPTATVMPTTQVESQEAMQ-SEGPVEHVPVFGSTSGSVRSTSPNVQPSISQPILT 1765
Query: 852 --------ALLQETKELKNEIKALSEERTA-IKEQLDSS-----NSTIAILQTEKDKLEL 897
A +Q T++ +I+ ++E ++ I E + SS +++ A+ T
Sbjct: 1766 VQQQTQATAFVQPTQQSHPQIEPANQELSSNIVEVVQSSPVERPSTSTAVFGTVSATPSS 1825
Query: 898 EITD-SKKEQDDLLVLLADQ---DQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESE 953
+ +++E++D + +DQ D + L KLK + PV E+E+ + + D + E++
Sbjct: 1826 SLPKRTREEEEDSTIEASDQVSDDTVEMPLPKKLKSV-TPVGTEEEVMAEESTDGEVETQ 1884
Query: 954 DPGKD 958
+D
Sbjct: 1885 VYNQD 1889
Score = 45.1 bits (105), Expect = 3e-04
Identities = 45/302 (14%), Positives = 134/302 (44%), Gaps = 39/302 (12%)
Query: 618 KELEGVITKAIYKSSEEDKKEEEVKKT---LEQHDNIVTHYKNMIREQDLQLEELRQQVS 674
++++ ++++ + + +E +K + +EQ+ +VT + + ++ EE+R+ +
Sbjct: 932 EDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIE 991
Query: 675 TLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGR 734
++ + QT + +++ ++++ K + +D++ + I
Sbjct: 992 VRLKESAEFQTQLEKKLMEVEKEKQEL--------QDDKRRA---------------IES 1028
Query: 735 LREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQEL 794
+ +++ ELK+ +Q+++ E ++ + T+ +NEQ + RD ++ A++ E
Sbjct: 1029 MEQQLSELKKTLSSVQNEVQEA------LQRASTALSNEQQ----ARRDCQEQAKIAVEA 1078
Query: 795 AT-LKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSAL 853
+ +L + ++ LQ K+++ + E + E+ + E R L
Sbjct: 1079 QNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERML 1138
Query: 854 LQETKELKNEIKALSEERTAIKEQLD--SSNSTIAILQTEKDKLELEITDSKKEQDDLLV 911
E + + L ++ + +Q++ S ++ + + L + +++ K Q+ +L
Sbjct: 1139 KDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILE 1198
Query: 912 LL 913
+L
Sbjct: 1199 IL 1200
Score = 41.6 bits (96), Expect = 0.004
Identities = 60/321 (18%), Positives = 130/321 (40%), Gaps = 48/321 (14%)
Query: 612 EFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQ 671
E KL +L+ + K +D+ + + + +++IR + +EL
Sbjct: 81 ELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEY 140
Query: 672 QVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEE 731
+K NE+L+ + T + ++Q D+ + + Y E
Sbjct: 141 LTEDVKRLNEKLKESNTTK-GELQLKLDELQASDVSV--------KYRE----------- 180
Query: 732 IGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSAR-----DSEQ 786
+ L++ +ELL SQ T ++ ++ + E+ + I+ + E+
Sbjct: 181 --------KRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEE 232
Query: 787 VAELKQELATLKSQLN--SQSVE--ITKLQTEKQELLQKTEAFAKSVEVQGETETIIATK 842
V+ L++++ LK+ + VE +TKL+ K++ E F + + + +
Sbjct: 233 VSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSA 292
Query: 843 TTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDS 902
D E + + L + +EL +K E AI++ L ++ KD++E E+ +
Sbjct: 293 ADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHL-------LEVEQSKDQMEKEMLEK 345
Query: 903 ----KKEQDDLLVLLADQDQK 919
+KE ++ LL+ +K
Sbjct: 346 IGRLEKELENANDLLSATKRK 366
Score = 41.2 bits (95), Expect = 0.005
Identities = 69/330 (20%), Positives = 134/330 (40%), Gaps = 51/330 (15%)
Query: 626 KAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQ------ 679
K I + E+ K + LE+ DN R ++Q+++L QQ+ L +
Sbjct: 463 KEIQRLQEDTDKANKQSSVLER-DN---------RRMEIQVKDLSQQIRVLLMELEEARG 512
Query: 680 -----NEQLQTAVTQQVSQ-IQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIG 733
+E++ +A S+ I QH Y ++ +L + NQ + E+G
Sbjct: 513 NHVIRDEEVSSADISSSSEVISQHLVSYRNIE-ELQQQNQRLL----------VALRELG 561
Query: 734 RLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQS--SAIVSARDSEQVAELK 791
RE E+ + ++ + QL + +S + ++ + S ++ +IV RD ++ L
Sbjct: 562 ETREREEQETTSSKITELQL-KLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRI--LL 618
Query: 792 QELATLKSQLNSQSVEITKL-QTEKQELLQKTEAFAKSVEVQGETETIIAT----KTTDV 846
+ + L++ S++ L T K+ +T + V V TE I A + ++
Sbjct: 619 SQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEI 678
Query: 847 EGRLSALLQETKELKNE--------IKALSEERTAIKEQLDSSNSTIAILQTEKDKLELE 898
E ++++NE + L + T I QLD ++ +LQ + E
Sbjct: 679 FENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRRE 738
Query: 899 ITDSKKEQDDLLVLLADQDQKILSLKNKLK 928
IT + L Q+Q I ++ L+
Sbjct: 739 ITSLHERNQKLTATTQKQEQIINTMTQDLR 768
Score = 35.8 bits (81), Expect = 0.20
Identities = 33/133 (24%), Positives = 66/133 (49%), Gaps = 15/133 (11%)
Query: 827 KSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNST-- 884
KSV G E ++A ++TD E Q++++ E + T +++ ++S S
Sbjct: 1860 KSVTPVGTEEEVMAEESTDGEVETQVYNQDSQDSIGE-GVTQGDYTPMEDSEETSQSLQI 1918
Query: 885 -IAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESG 943
+ LQ+++ + D + + DD++V+ +D +++ D + E ED E
Sbjct: 1919 DLGPLQSDQ-QTTTSSQDGQGKGDDVIVIDSDDEEE--------DDDENDGEHEDYEE-- 1967
Query: 944 DQEDEDDESEDPG 956
D+ED+DD+ +D G
Sbjct: 1968 DEEDDDDDEDDTG 1980
Score = 33.5 bits (75), Expect = 0.98
Identities = 39/168 (23%), Positives = 71/168 (42%), Gaps = 39/168 (23%)
Query: 816 QELLQKTEAFAKSVEVQGETETIIATKTTDVEG---------------------RLS--- 851
Q++L++TE VQ + E +A + ++++G RLS
Sbjct: 6 QQVLERTELNKLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQ 65
Query: 852 -ALLQETKE----------LKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEIT 900
L+ ET+E L N++KAL+E+ ++ D + + + K++LE E
Sbjct: 66 ERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKR 125
Query: 901 DSKKEQDDLLVLLADQDQKILSLKNKLKD----LGHPVEEEDELESGD 944
D + + L L + + L KLK+ G + DEL++ D
Sbjct: 126 DLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASD 173
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 68.6 bits (166), Expect = 3e-11
Identities = 79/370 (21%), Positives = 162/370 (43%), Gaps = 61/370 (16%)
Query: 612 EFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNM---IREQDLQLEE 668
E + KE + + SE D+ +E +K+ + +H K ++EQ+ + E
Sbjct: 1436 EMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINE 1495
Query: 669 LR-------QQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKI--------QLGKDNQ 713
LR ++ST++ Q E + + ++ +I + ++Q+N+ +I +L + +
Sbjct: 1496 LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKE 1555
Query: 714 HQGSYSEGAQ---------MNGIQ--PEEIGRLREEIEELKRNQELLQSQLTEKDSMIEN 762
H+ + Q N +Q EEI + +E EE+KR QE LQ E+D + EN
Sbjct: 1556 HRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQ---IERDQLKEN 1612
Query: 763 MKS--SQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQ 820
K ++ + E+ + + E E+ LK Q +Q + + ++TE ++
Sbjct: 1613 TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETEN---IR 1669
Query: 821 KTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDS 880
T+ +++E + ++ +E +L++ + L ER +KE L
Sbjct: 1670 LTQILHENLE------------------EMRSVTKERDDLRSVEETLKVERDQLKENL-- 1709
Query: 881 SNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDEL 940
TI ++++L++ K+ Q+ + L +K + N KDL H D L
Sbjct: 1710 -RETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEH---SNDAL 1765
Query: 941 ESGDQEDEDD 950
++ D + +++
Sbjct: 1766 KAQDLKIQEE 1775
Score = 67.0 bits (162), Expect = 8e-11
Identities = 74/351 (21%), Positives = 168/351 (47%), Gaps = 51/351 (14%)
Query: 636 KKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQ 695
KKE E+ +T ++ + + ++E+ QL+E +QQ+ ++ + ++Q +++++I+
Sbjct: 1110 KKEGELSRTCDR----LAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQ----KKINEIE 1161
Query: 696 QHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTE 755
K++ ++ L + ++ N + + I + R+ ++EL+++ E TE
Sbjct: 1162 NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFE------TE 1215
Query: 756 KDSMIENMKSSQTSGTNEQSSAIVS----ARDSEQVAELKQELATLKSQL-NSQSVEI-- 808
+D + ++ + +G + ++ E + EL++ ++ +Q+ N+Q +E
Sbjct: 1216 RDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSH 1275
Query: 809 TKLQTE------KQELLQKTEAFAKSVEVQGETETIIATKTTD-------VEGRLSALLQ 855
TKLQ E +QELL + +++ E E E + TT +E L +
Sbjct: 1276 TKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNE 1335
Query: 856 ETKELKNEIKALSEER---TAIKEQLDSSN--------STIAILQTEKDKLELEITDSKK 904
+ +E + EIK+L++ER IKE L+ + T+A +Q + K E + +K
Sbjct: 1336 KFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEK 1395
Query: 905 EQDDLLVL-----LADQDQKILSLKNKLKDLGHPVEE-EDELESGDQEDED 949
+ + ++ +D +L ++ ++ L ++E DE++S +E +D
Sbjct: 1396 DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDD 1446
Score = 64.7 bits (156), Expect = 4e-10
Identities = 86/422 (20%), Positives = 180/422 (42%), Gaps = 52/422 (12%)
Query: 548 SIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYM 607
S + +LE +KEK+K+L EN I+ ++ A +K Q +
Sbjct: 641 SAFLRSENLE--LKEKMKELATTYKQMENDIQL------YQSQLEAKKKMQVDLEKELQS 692
Query: 608 IFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLE 667
F+ E TKL ++G + K + + E + K +++K L + +RE+ + L
Sbjct: 693 AFN-EITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKE----VEENEALREEVILLS 747
Query: 668 ELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGI 727
EL+ S ++ +++Q ++++ I KD+ L + K+++ QG
Sbjct: 748 ELKSLPSEVERLRKEIQDK-SEELHIITSEKDK--LFSEVVHKESRVQG----------- 793
Query: 728 QPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIV-SARDSEQ 786
L EEI + K + QS D +N K+ + + + R +++
Sbjct: 794 -------LLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQE 846
Query: 787 VAELKQE-------LATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGET---- 835
+ L +E L LK++L+ ++ E+ + E QE L + E + +E + T
Sbjct: 847 IVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTV 906
Query: 836 ---ETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEK 892
+T+I K + L QE +LK ++L ER +K + + T+ + +
Sbjct: 907 EREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDI---HDTVNMNIDTQ 963
Query: 893 DKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDES 952
++L + K+ Q+ + L + +++ + ++ G +E + G + +D E+
Sbjct: 964 EQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEA 1023
Query: 953 ED 954
++
Sbjct: 1024 KN 1025
Score = 61.2 bits (147), Expect = 4e-09
Identities = 83/355 (23%), Positives = 161/355 (45%), Gaps = 57/355 (16%)
Query: 607 MIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQL 666
++ + TK L + + + + + + +EE+K ++ DN+ T + + + D
Sbjct: 1310 LLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLK 1369
Query: 667 EELRQQVSTLK-CQNEQLQTA--------VTQQVSQIQQHKDQYN-LLKIQ---LGKDNQ 713
E +R+ ++ ++ Q++Q Q+ T+ VS+++Q K + + LL+I+ LG +
Sbjct: 1370 EHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKR 1429
Query: 714 HQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNE 773
Q S+ +E+ + +E ++L+R QE+LQS E D + EN+K
Sbjct: 1430 LQESH-----------DEMKSVAKEKDDLQRLQEVLQS---ESDQLKENIKE-------- 1467
Query: 774 QSSAIVSARDSEQVAELKQELATLKSQ---LNSQSVEITKLQTEKQELLQKTEAFAKSVE 830
+ A+ E ELK LK Q +N V +++ +TE + ++ EA + +
Sbjct: 1468 -----IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAI--NDK 1520
Query: 831 VQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQT 890
+Q + + I + E + E +E NE+K E R A L S S + L
Sbjct: 1521 LQNKIQEIYEKE----EQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTN 1576
Query: 891 EKDKLELEITDSKKEQDDLL----VLLADQDQKILSLKNKLKDLGHPVEEEDELE 941
+ + EI KE++++ L ++DQ LK K++ ++E E E
Sbjct: 1577 RLQESQEEIQIMIKEKEEMKRVQEALQIERDQ----LKENTKEIVAKMKESQEKE 1627
Score = 58.9 bits (141), Expect = 2e-08
Identities = 76/328 (23%), Positives = 144/328 (43%), Gaps = 55/328 (16%)
Query: 635 DKKEEEVKK-----TLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQ 689
DKK++ K T + DN + + I + EL+Q + ++ + EQL+T + +
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075
Query: 690 QVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGA-QMNGIQPEEIGRLREEIEELKRNQEL 748
+ +++++ LL +L K + A + G RL E E+LK +
Sbjct: 1076 NIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQ- 1134
Query: 749 LQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQ---ELATLKSQLNSQS 805
QL EK + N++ E+++E+++ E+ LK++L ++
Sbjct: 1135 ---QLQEKQQQLLNVQ--------------------EEMSEMQKKINEIENLKNELKNKE 1171
Query: 806 VEITKLQTEKQELLQK-------TEAFAKSVEVQGETETIIATKTTDVEGRLSAL----L 854
+ + ++TE+ EL QK ++ K +V E + T+ + G + + L
Sbjct: 1172 LTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGL 1231
Query: 855 QETKELKNEIKALSEERTAIKEQLDS-SNSTIAILQTEKDKLELEITDSKKEQDDLLVLL 913
Q +ELK L E + I E S S T I+ T+ +LE + +K Q+++ VL
Sbjct: 1232 QTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ----DLEKSHTKL-QEEIPVLH 1286
Query: 914 ADQDQKILSLKNKLKDLGHPVEEEDELE 941
+Q+ L +K++ E +ELE
Sbjct: 1287 EEQE-----LLPNVKEVSETQETMNELE 1309
Score = 58.5 bits (140), Expect = 3e-08
Identities = 86/360 (23%), Positives = 156/360 (43%), Gaps = 38/360 (10%)
Query: 605 EYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDL 664
E + E K L + T+ YK+ E +K EV++ L + + + +N R+ L
Sbjct: 846 EIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLEN--RDSTL 903
Query: 665 QLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLK--IQLGKDNQHQGSYSEGA 722
Q E + + T K Q ++V + Q KD L+ +Q+ +D Q + +
Sbjct: 904 QTVEREKTLITEKLQQ------TLEEVKTLTQEKDDLKQLQESLQIERD-QLKSDIHDTV 956
Query: 723 QMNGIQPEEIGRLREEIEELKRNQEL---LQSQLTEKDSMIENMKSSQTSGTNEQSSAIV 779
MN I +E +LR +E LK++QE L+S+++E+ S +M+ + T T ++ +
Sbjct: 957 NMN-IDTQE--QLRNALESLKQHQETINTLKSKISEEVSRNLHMEEN-TGETKDEFQQKM 1012
Query: 780 SARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETII 839
D +Q E K TL + + EI + Q + L+Q+ E+Q E++I
Sbjct: 1013 VGIDKKQDLEAKNT-QTLTADVKDN--EIIEQQRKIFSLIQEKN------ELQQMLESVI 1063
Query: 840 ATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEI 899
A K Q +LK I+ E + ++ D I+ EK+ +
Sbjct: 1064 AEKE-----------QLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKE 1112
Query: 900 TDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDL 959
+ + D L + +K L+ K + L + EE E++ E E+ ++E K+L
Sbjct: 1113 GELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKEL 1172
Score = 56.6 bits (135), Expect = 1e-07
Identities = 97/489 (19%), Positives = 200/489 (40%), Gaps = 66/489 (13%)
Query: 476 QQCTNILSQGSKIQTRVGLLMLLCTWLSNCPIAVTHFLHNSANVPFLTGQIAENLGEEEQ 535
Q+ N+ + K + +G L T + + + T ++ E L E EQ
Sbjct: 845 QEIVNLSKEAQKFDSSLGALK-------------TELSYKTQELQEKTREVQERLNEMEQ 891
Query: 536 LVQGLCALLLGISIYFNDNSLESYMKEKLKQLIE--KRIGKENF----IEKLGFISKHEL 589
L + L + + +L + EKL+Q +E K + +E +++ I + +L
Sbjct: 892 LKEQLENRDSTLQTVEREKTL---ITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQL 948
Query: 590 YSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHD 649
S N + E + E K +E + + K EEV + L +
Sbjct: 949 KSDIHDTVNMNIDTQEQLRNALESLKQHQETINTL---------KSKISEEVSRNLHMEE 999
Query: 650 NIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLG 709
N K+ +++ + +++ + L+ +N Q TA + I+Q + ++L++ +
Sbjct: 1000 N-TGETKDEFQQKMVGIDKKQD----LEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE 1054
Query: 710 KDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTS 769
+ +E Q+ E I E EEL+ LL +L ++ ++ K+
Sbjct: 1055 LQQMLESVIAEKEQLKTDLKENIEMTIENQEELR----LLGDELKKQQEIVAQEKNHAIK 1110
Query: 770 GTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAK-S 828
E S R +++AE++++L QL + ++ +Q E E+ +K
Sbjct: 1111 KEGELS------RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLK 1164
Query: 829 VEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAIL 888
E++ + T+ +T +E L Q+ E E+K++++ER +KE S
Sbjct: 1165 NELKNKELTLEHMETERLE-----LAQKLNENYEEVKSITKERKVLKELQKS-------F 1212
Query: 889 QTEKDKL-----ELEIT--DSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELE 941
+TE+D L E+E T +K+E + L + + I L+ + + + +LE
Sbjct: 1213 ETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLE 1272
Query: 942 SGDQEDEDD 950
+ +++
Sbjct: 1273 KSHTKLQEE 1281
Score = 52.4 bits (124), Expect = 2e-06
Identities = 73/338 (21%), Positives = 147/338 (43%), Gaps = 37/338 (10%)
Query: 617 VKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQL-EELRQQVST 675
+KE + I K SE+ + ++K LE H + ++ QDL++ EELR
Sbjct: 1730 LKEHQETIDKLRGIVSEKTNEISNMQKDLE-------HSNDALKAQDLKIQEELRIAHMH 1782
Query: 676 LKCQNEQLQ------TAVTQQVSQIQQHKDQYNLL---KIQLGKDNQHQGSYSEGAQMNG 726
LK Q E + + T ++S +Q+ + N KIQ K N+HQ +
Sbjct: 1783 LKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK------ 1836
Query: 727 IQPEEIGRLREEIEELKRNQELLQSQ-LTEKDSMIENMKSSQTSGTN-EQSSAIVSARDS 784
+++ ++++ E+++ ++ ++ Q LT IEN+ +Q N E+ +++ RD+
Sbjct: 1837 ---KDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDN 1893
Query: 785 EQVAE--LKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATK 842
+ E LK E LK L ++Q E + ++ ++V+ E + +
Sbjct: 1894 LRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQ 1953
Query: 843 TTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDS 902
+D++ L E ++ E++ + +KE ++ S+ I ++ K + E +
Sbjct: 1954 ISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSM 2013
Query: 903 KKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDEL 940
+ + D Q L L+++ +E DEL
Sbjct: 2014 QS-------VRMDNFQLTKKLHESLEEIRIVAKERDEL 2044
Score = 37.0 bits (84), Expect = 0.089
Identities = 72/345 (20%), Positives = 144/345 (41%), Gaps = 53/345 (15%)
Query: 612 EFTKLVKELEGVITKAIYKSSEEDKKEEEVKK-TLEQHDNIVTHYKNMIREQDLQLEELR 670
EF +++K+L+ V++ Y + ++++ E + K ++ D + + +I+ Q LQ +
Sbjct: 2165 EFHRIMKKLKYVLS---YVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQD--- 2218
Query: 671 QQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPE 730
V + + ++ +L + + +I + + I+ + Q S +M E
Sbjct: 2219 CDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIK----TEFQQVLSNRKEMTQFLEE 2274
Query: 731 EIGRLREEIEELKRNQELLQSQLTEKDSMIEN--MKSSQTSGTNEQSSAIVSARDSEQVA 788
+ R +IE+LK + ++ + ++ N + S E+ SA +S + +
Sbjct: 2275 WLNT-RFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLK 2333
Query: 789 ELKQE-------LATLKSQLNSQSV---------------EITKLQTEKQELLQKTEAFA 826
LK++ TLK+ L S + T+L TEK L+ + A
Sbjct: 2334 SLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEA 2393
Query: 827 KSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIA 886
K + E++ I K +V + A LQ N+ L+ + TI
Sbjct: 2394 KESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKC-------------LEKTKETIQ 2440
Query: 887 ILQTEKDKLELEITDSKKEQDDLLVLLADQD-QKILSLKNKLKDL 930
+LQ DK+ L K+E +DL + L D +K+ + K K++
Sbjct: 2441 VLQ---DKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEI 2482
Score = 33.9 bits (76), Expect = 0.75
Identities = 52/276 (18%), Positives = 116/276 (42%), Gaps = 29/276 (10%)
Query: 653 THYKNMIREQDLQLEELRQQVSTLKCQNEQL------QTAVTQQVSQIQQHKDQYNLLKI 706
T Y N + + L+ R+++ LK Q E++ Q Q++Q+ + KD L K+
Sbjct: 332 TPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDL--LQKV 389
Query: 707 QLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSS 766
Q K + + Q + R R L + ++ S ++ ++ N+ +
Sbjct: 390 QNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTK 449
Query: 767 ----QTSGTNEQSSAIVSARDS-----EQVAELKQELAT-------LKSQLNSQSVEITK 810
+ E ++ S D + ++E++ AT ++S+LNS +
Sbjct: 450 THKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDN 509
Query: 811 LQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEE 870
L + ++L + E ++ + + + A + + + L+ E LKN +K
Sbjct: 510 LVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVY 569
Query: 871 RTAIKEQLDSSNSTIAILQTEKDKLE--LEITDSKK 904
++ +L +S + +L+ ++D+++ E DS+K
Sbjct: 570 NQDLENEL---SSKVELLREKEDQIKKLQEYIDSQK 602
>gi|41872583 Rho-associated, coiled-coil containing protein kinase 2
[Homo sapiens]
Length = 1388
Score = 67.0 bits (162), Expect = 8e-11
Identities = 66/280 (23%), Positives = 136/280 (48%), Gaps = 23/280 (8%)
Query: 633 EEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVS 692
+ D + +E++ LE T YK +RE + EE + L+ + ++LQ +
Sbjct: 854 DADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAA 913
Query: 693 QIQQHKDQYNLLKIQLGKDNQHQGSYSEGA-QMNGIQPEEIGRLREEIEELKRNQELLQS 751
Q L+I L K + Q + S Q + ++ E+I + E E + R+++
Sbjct: 914 Q----------LEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQ---- 959
Query: 752 QLTEKDSMIENMKSSQTSGTNEQSSAIVSARD-SEQVAELKQELATLKSQLNSQSVEITK 810
+LTEKD+ I +++ + + T++ ++ + + ++ +++++L+ LK + S K
Sbjct: 960 ELTEKDATIASLEETNRTLTSDVANLANEKEELNNKLKDVQEQLSRLKDE--EISAAAIK 1017
Query: 811 LQTEKQELLQ---KTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKAL 867
Q EKQ L + KT+A K E+ E + TDV + + ELK+E + L
Sbjct: 1018 AQFEKQLLTERTLKTQAVNKLAEIMNRKEPVKRGNDTDVRRKEKENRKLHMELKSEREKL 1077
Query: 868 SEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQD 907
+++ +++L+ + IA + + ++EL++T K+ D
Sbjct: 1078 TQQMIKYQKELNEMQAQIA--EESQIRIELQMTLDSKDSD 1115
Score = 58.2 bits (139), Expect = 4e-08
Identities = 79/440 (17%), Positives = 184/440 (41%), Gaps = 73/440 (16%)
Query: 558 SYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLV 617
+Y + ++Q +E+ E+ K K+++Y + E + + K
Sbjct: 691 TYQLKVIQQSLEQEEA-EHKATKARLADKNKIYESIEEAKSEAMKEMEKKLLEERTLK-- 747
Query: 618 KELEGVITKAIYKSSEED----KKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQV 673
+++E ++ +A + S D + ++++ + L+Q D + +N+ + + + ++
Sbjct: 748 QKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQ 807
Query: 674 STLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGA--QMNGIQPE- 730
+ LK Q +Q+ T + Q++Q + +K+ L K N + A QM +Q +
Sbjct: 808 NDLKMQTQQVNTLKMSE-KQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQL 866
Query: 731 ------------EIGRLREEIEEL----KRNQELLQSQLTEKDSMIENMKSSQTSGTNEQ 774
++ L+EE EE K Q+ Q E+DS+ ++ + T +EQ
Sbjct: 867 EAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLEITLTKADSEQ 926
Query: 775 SSAIVS----------------------ARDSEQVAELKQELATLKSQLNSQSVEITKLQ 812
+ ++ AR +++ E +A+L+ + + ++ L
Sbjct: 927 LARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANLA 986
Query: 813 TEKQEL-------------LQKTEAFAKSVEVQGETETIIA-TKTTDVEGRLSALLQETK 858
EK+EL L+ E A +++ Q E + + T T +L+ ++ +
Sbjct: 987 NEKEELNNKLKDVQEQLSRLKDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIMNRKE 1046
Query: 859 ELK--NEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQ 916
+K N+ +E+ K ++ L++E++KL ++ +KE +++ +A++
Sbjct: 1047 PVKRGNDTDVRRKEKENRKLHME--------LKSEREKLTQQMIKYQKELNEMQAQIAEE 1098
Query: 917 DQKILSLKNKLKDLGHPVEE 936
Q + L+ L +E+
Sbjct: 1099 SQIRIELQMTLDSKDSDIEQ 1118
Score = 53.1 bits (126), Expect = 1e-06
Identities = 78/388 (20%), Positives = 165/388 (42%), Gaps = 60/388 (15%)
Query: 612 EFTKLVKELEGVITKAIYKSSEEDKKE-EEVKKTLEQH----DNIVTHYKNMIREQDLQL 666
E KL E E + ++ +S D+ E+ L+ + + + K ++ + +L+
Sbjct: 610 ETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKVELEK 669
Query: 667 EELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQ----YNLLKIQLGKDNQHQGSYSEGA 722
+L+++ + L+ + ++ +T Q+ IQQ +Q + K +L N+ S E
Sbjct: 670 RQLQERFTDLEKEKSNMEIDMTYQLKVIQQSLEQEEAEHKATKARLADKNKIYESIEEAK 729
Query: 723 QMNGIQPE----EIGRLREEIE---------------ELKRNQELLQSQLTEKDSMIENM 763
+ E E L++++E +LK++Q+ + L +KD + E++
Sbjct: 730 SEAMKEMEKKLLEERTLKQKVENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDV 789
Query: 764 KSSQTSGTNEQSSAIVSARD----SEQV-------AELKQE---LATLKSQLNSQSVEIT 809
++ E ++ D ++QV +LKQE L +K L Q+ E+
Sbjct: 790 RNLTLKIEQETQKRCLTQNDLKMQTQQVNTLKMSEKQLKQENNHLMEMKMNLEKQNAELR 849
Query: 810 KLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSE 869
K E+Q+ + + +E + T+ T+ +++ + KEL+ + + L +
Sbjct: 850 K---ERQDADGQMKELQDQLEAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQD 906
Query: 870 ERTAIKEQL-------DSSNSTIAILQTEKDKLELEITDSKKEQDDLLVL----LADQDQ 918
ER ++ QL DS +I + + LE E + E +++ L ++D
Sbjct: 907 ERDSLAAQLEITLTKADSEQLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDA 966
Query: 919 KILSL----KNKLKDLGHPVEEEDELES 942
I SL + D+ + E++EL +
Sbjct: 967 TIASLEETNRTLTSDVANLANEKEELNN 994
Score = 47.8 bits (112), Expect = 5e-05
Identities = 61/315 (19%), Positives = 143/315 (45%), Gaps = 21/315 (6%)
Query: 632 SEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVST-LKCQNEQLQTAVTQQ 690
S + +K EE ++ ++ + H N ++ ++ +LE+ + V+T L+ ++L+ +T +
Sbjct: 433 SIQSRKNEESQEIQKKLYTLEEHLSNEMQAKE-ELEQKCKSVNTRLEKTAKELEEEITLR 491
Query: 691 VS---QIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQE 747
S ++Q + + LL+ K+ ++Q A ++ L++++E+LK+ +
Sbjct: 492 KSVESALRQLEREKALLQ---HKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQ 548
Query: 748 LLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVE 807
Q TEK + ++ + +S R ++ AE +++ L+S +
Sbjct: 549 NSQIS-TEKVNQLQRQLDETNALLRTESDTAARLRKTQ--AESSKQIQQLESNNRDLQDK 605
Query: 808 ITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKAL 867
L+T K +L ++ ++E + T + D++GR+ L ++ K K + +
Sbjct: 606 NCLLETAKLKLEKEFINLQSALESERRDRTHGSEIINDLQGRICGLEEDLKNGKILLAKV 665
Query: 868 SEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKL 927
E+ ++E+ L+ EK +E+++T K + L ++ + + K +L
Sbjct: 666 ELEKRQLQERFTD-------LEKEKSNMEIDMTYQLKV---IQQSLEQEEAEHKATKARL 715
Query: 928 KDLGHPVEEEDELES 942
D E +E +S
Sbjct: 716 ADKNKIYESIEEAKS 730
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 67.0 bits (162), Expect = 8e-11
Identities = 90/432 (20%), Positives = 178/432 (41%), Gaps = 46/432 (10%)
Query: 555 SLESYMK-EKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEF 613
S ES M E KQ IE+++ K+ F EL ++ S ++ E
Sbjct: 1066 SQESIMDLENDKQQIEEKLKKKEF----------ELSQLQAKIDDEQVHSLQFQKKIKEL 1115
Query: 614 TKLVKELEGVI-------TKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQL 666
++ELE I K + S+ ++ EE+ + LE+ + M ++++ +
Sbjct: 1116 QARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEF 1175
Query: 667 EELRQQVSTLKCQNEQ----LQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGA 722
+++R+ + Q+E L+ V+++ + D +K +L K+ +
Sbjct: 1176 QKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDM 1235
Query: 723 QMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIE------NMKSSQTSGTNEQSS 776
N E + + + IE R E S++ KD NM+ ++ N + S
Sbjct: 1236 ASN---IEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELS 1292
Query: 777 AIVSARDS--EQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKT--------EAFA 826
V ++S Q+ + KQ L +L Q E TK + LQ + E +
Sbjct: 1293 HRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYE 1352
Query: 827 KSVEVQGETETIIATKTTDVEGRLSAL----LQETKELKNEIKALSEERTAIKEQLDSSN 882
+ E + E + ++ ++V + +Q T+EL+ K L++ +E +++N
Sbjct: 1353 EEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETAN 1412
Query: 883 STIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEE-EDELE 941
S A L+ K +L+ E+ D ++ + A D+K + L + ++E + ELE
Sbjct: 1413 SKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELE 1472
Query: 942 SGDQEDEDDESE 953
+ +E +E
Sbjct: 1473 AAQKESRSLSTE 1484
Score = 57.8 bits (138), Expect = 5e-08
Identities = 70/346 (20%), Positives = 146/346 (42%), Gaps = 61/346 (17%)
Query: 667 EELRQQVSTLKCQNEQLQTAV---TQQVSQ--------------IQQHKDQYNLLKIQLG 709
EE+ Q+ TL+ +N+ LQ + T+Q+++ ++Q K + ++
Sbjct: 1493 EEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVE 1552
Query: 710 KDNQHQGS-----YSEGAQMNGIQPEEIGRLREEIEELKRN--------QELLQSQLTEK 756
+H+ S E +Q+ ++ EEIE+LKRN Q +L +++ +
Sbjct: 1553 GSLEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSR 1612
Query: 757 DSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQ 816
+ + +K NE I + Q+AE ++ L T++ QL + + +
Sbjct: 1613 NDAL-RLKKKMEGDLNEME--IQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNE 1669
Query: 817 E--------------LLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKN 862
+ LL++ E ++E T + + D R+ L + L N
Sbjct: 1670 DLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLIN 1729
Query: 863 EIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDS-------KKEQDDLLVLLAD 915
K L + + ++++S I + ++K + ITD+ KKEQD A
Sbjct: 1730 TKKKLEADIAQCQAEVENS---IQESRNAEEKAKKAITDAAMMAEELKKEQD----TSAH 1782
Query: 916 QDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDH 961
++ +L+ +KDL H ++E ++L + + + E+ ++L++
Sbjct: 1783 LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELEN 1828
Score = 57.4 bits (137), Expect = 6e-08
Identities = 63/326 (19%), Positives = 140/326 (42%), Gaps = 47/326 (14%)
Query: 626 KAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQT 685
K + KS+E +K+ +K+ E+ K + + + +EL +++ +L + LQ
Sbjct: 841 KPLLKSAEAEKEMATMKEDFERT-------KEELARSEARRKELEEKMVSLLQEKNDLQL 893
Query: 686 AVTQQVSQIQQHKDQYN-LLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKR 744
V + + +++ L+K ++ + ++ L E +EE
Sbjct: 894 QVQSETENLMDAEERCEGLIKSKI------------------LLEAKVKELTERLEE--- 932
Query: 745 NQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQ 804
+E + S+L K +E+ SS ++ + + E K + L ++ +
Sbjct: 933 -EEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENK--VKNLSEEMTAL 989
Query: 805 SVEITKLQTEKQELLQKTEAFAKSVEVQGE-------TETIIATKTTDVEGRLSALLQET 857
I+KL EK+ L + + ++V+ + + +T D+EG L++
Sbjct: 990 EENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGS----LEQE 1045
Query: 858 KELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQD 917
K+L+ + L + ++ L S +I L+ +K ++E ++ + E L + D+
Sbjct: 1046 KKLRAD---LERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQ 1102
Query: 918 QKILSLKNKLKDLGHPVEE-EDELES 942
L + K+K+L +EE E+E+E+
Sbjct: 1103 VHSLQFQKKIKELQARIEELEEEIEA 1128
Score = 55.1 bits (131), Expect = 3e-07
Identities = 65/320 (20%), Positives = 142/320 (44%), Gaps = 21/320 (6%)
Query: 636 KKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQ 695
K + +++T ++ + K +Q + +L Q + L+ QN +L V ++ S I
Sbjct: 1244 KSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLIS 1303
Query: 696 QHKDQYNLLKIQLG--KDNQHQGSYSEGAQMNGIQPE--EIGRLREEIEELKRNQELLQS 751
Q L QL K + + ++ A + +Q + LRE+ EE + + LQ
Sbjct: 1304 QLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363
Query: 752 QLTEKDSMIENMKSSQTSGTNEQSSAIVSARD--SEQVAELKQELATLKSQLNSQSVEIT 809
L++ +S + ++ + +++ + A+ ++++ E ++ T S+ S
Sbjct: 1364 ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQ 1423
Query: 810 KLQTEKQELLQKTE----AFAKSVEVQGETETIIAT---KTTDVEGRLSALLQETKELKN 862
+LQ E ++L++ E A A + Q + ++A K + + L A +E++ L
Sbjct: 1424 RLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLST 1483
Query: 863 EIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILS 922
E+ + + +QL++ L+ E L+ EI+D ++ + L + ++
Sbjct: 1484 ELFKMRNAYEEVVDQLET-------LRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKL 1536
Query: 923 LKNKLKDLGHPVEE-EDELE 941
++ + DL +EE E LE
Sbjct: 1537 VEQEKSDLQVALEEVEGSLE 1556
Score = 52.8 bits (125), Expect = 2e-06
Identities = 44/179 (24%), Positives = 88/179 (49%), Gaps = 28/179 (15%)
Query: 788 AELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKS-----VEVQGETETIIATK 842
AE ++E+AT+K E+ + + ++EL +K + + ++VQ ETE ++
Sbjct: 847 AEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLM--- 903
Query: 843 TTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDS 902
D E R L++ L+ ++K L+E R +E+++S L +K LE + +
Sbjct: 904 --DAEERCEGLIKSKILLEAKVKELTE-RLEEEEEMNSE------LVAKKRNLEDKCSSL 954
Query: 903 KKEQDDLLVLLADQDQKILSLKNKLKDLGHPV-----------EEEDELESGDQEDEDD 950
K++ DDL + L +++ + +NK+K+L + +E+ L+ Q+ DD
Sbjct: 955 KRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDD 1013
Score = 46.2 bits (108), Expect = 1e-04
Identities = 68/346 (19%), Positives = 150/346 (43%), Gaps = 60/346 (17%)
Query: 610 DHEFTKLVK---ELEGVITKAIYKSSEEDKKEEEVKKT---------------LEQHDNI 651
+HE +K+++ EL V ++ K E+D++ E++K+ + ++
Sbjct: 1556 EHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDA 1615
Query: 652 VTHYKNM---IREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQL 708
+ K M + E ++QL +Q++ + + L+T V Q+ Q H D ++
Sbjct: 1616 LRLKKKMEGDLNEMEIQLGHSNRQMAETQ---KHLRT-VQGQLKDSQLHLDD----ALRS 1667
Query: 709 GKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQT 768
+D + Q + E + NG+ EE+ ++ +E+ +R + L + +L + ++ + S T
Sbjct: 1668 NEDLKEQLAIVE--RRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNT 1725
Query: 769 SGTN--------------EQSSAIVSARDSEQVAELK-QELATLKSQLNSQSVEITKLQT 813
S N E ++I +R++E+ A+ + A + +L + L+
Sbjct: 1726 SLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 814 EKQELLQKTEAF------AKSVEVQGETETI--IATKTTDVEGRLSALLQETKELKNEIK 865
K+ L Q + A+ + ++G + I + + ++E L E K +K
Sbjct: 1786 MKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELENELDV---EQKRGAEALK 1842
Query: 866 ALSEERTAIKE---QLDSSNSTIAILQTEKDKLELEITDSKKEQDD 908
+ +KE Q + + I LQ DKL+ ++ K++ ++
Sbjct: 1843 GAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEE 1888
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 67.0 bits (162), Expect = 8e-11
Identities = 68/319 (21%), Positives = 152/319 (47%), Gaps = 32/319 (10%)
Query: 636 KKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQ 695
KK E ++ H N+ H D QLE+ +++S + + +L + + QI
Sbjct: 414 KKMEPDEQLRNDHMNLRGH-----TPLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQIL 468
Query: 696 QHKDQYNLLK--IQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQL 753
+ +++ L+ IQL K ++ G Q++G + + + +LR+E +L+ E + ++
Sbjct: 469 RATEEFKQLEEAIQLKKISE-AGKDLLYKQLSG-RLQLVNKLRQEALDLELQMEKQKQEI 526
Query: 754 TEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQT 813
K I++++ + S + ++D + + +K + + + QL+ + + +L++
Sbjct: 527 AGKQKEIKDLQIAIDS---------LDSKDPKH-SHMKAQKSGKEQQLDIMNKQYQQLES 576
Query: 814 EKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTA 873
E+L + + ETE I + EG+++A K+L+ I L E
Sbjct: 577 RLDEILSR---------IAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGT 627
Query: 874 IKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHP 933
IK Q + + L+ EK+ L +T+ ++E+D L ++ D + +++ +L +L
Sbjct: 628 IKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAE----NMRKELAELESA 683
Query: 934 VEEEDELESGDQEDEDDES 952
++E+ E+ + Q+ + D S
Sbjct: 684 LQEQHEVNASLQQTQGDLS 702
Score = 65.1 bits (157), Expect = 3e-10
Identities = 93/419 (22%), Positives = 179/419 (42%), Gaps = 40/419 (9%)
Query: 558 SYMKEKLKQLIEK-----RIGKENFIEKLGFISKHELYSRASQ------KPQPNFPSPEY 606
S KEKL + ++K + + N L + + E+ +A + K Q E
Sbjct: 1537 SKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEM 1596
Query: 607 MIFDHEFTKLVKEL---EGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQD 663
+ D + +EL +G + +A + ++++ L + VT N IRE
Sbjct: 1597 AVLDRQLGHKKEELHLLQGSMVQA----------KADLQEALRLGETEVTEKCNHIREVK 1646
Query: 664 LQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQ 723
LEEL Q L Q + +T +T +I++ ++ L++ L + ++H+
Sbjct: 1647 SLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEEN---LQVVLRQMSKHKTELKNILD 1703
Query: 724 MNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMK--SSQTSGTNEQSSAIVSA 781
M ++ E+ L+ + ++ E Q + E+ +EN++ S Q G E ++
Sbjct: 1704 MLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLE- 1762
Query: 782 RDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIAT 841
RD ++ + E L+S + S E LQ EK ++ +K A K V E + +
Sbjct: 1763 RDKREIERMTAESRALQSCVECLSKEKEDLQ-EKCDIWEKKLAQTKRVLAAAEENSKMEQ 1821
Query: 842 KTTD-VEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTE----KDKLE 896
+ +E + L QE +L + +L + +A+++QL + LQ E +D L
Sbjct: 1822 SNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLN 1881
Query: 897 L---EITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVE-EEDELESGDQEDEDDE 951
L ++ + K QD LL + I N+ +D E ++ +L+ E E+++
Sbjct: 1882 LAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENK 1940
Score = 53.9 bits (128), Expect = 7e-07
Identities = 75/360 (20%), Positives = 156/360 (43%), Gaps = 48/360 (13%)
Query: 604 PEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQD 663
PE+ ++E ++L ++ + +K + K + K+ E H NI
Sbjct: 1316 PEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNI------------ 1363
Query: 664 LQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYN------LLKIQLGKDNQHQGS 717
++L Q+ +L+C+ E+L V ++ QQ KD + + ++++ K +H
Sbjct: 1364 ---DDLLQEKKSLECEVEELHRTVQKR----QQQKDFIDGNVESLMTELEIEKSLKHHED 1416
Query: 718 YSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSA 777
+ ++ I+ + R R E+ E R LL +E E K++ T+ + S
Sbjct: 1417 IVD--EIECIEKTLLKR-RSELREADR---LLAEAESELSCTKEKTKNAVEKFTDAKRSL 1470
Query: 778 IVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETET 837
+ + D+E++ QE A L ++ LQ + ++L Q K E+ E
Sbjct: 1471 LQTESDAEELERRAQETAV---NLVKADQQLRSLQADAKDLEQHK---IKQEEILKEINK 1524
Query: 838 IIATKTTD---VEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDK 894
I+A K +D + + L +E ++L+ +I+ + L S + + E +K
Sbjct: 1525 IVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEK 1584
Query: 895 LELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDL-GHPVEEEDELESGDQEDEDDESE 953
L+ ++T ++E +A D+++ K +L L G V+ + +L+ + E + +E
Sbjct: 1585 LKSQVTSQQQE-------MAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTE 1637
Score = 53.5 bits (127), Expect = 9e-07
Identities = 75/326 (23%), Positives = 145/326 (44%), Gaps = 41/326 (12%)
Query: 633 EEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVS 692
E +K+EE ++ L Q T KN++ L+ EL+ LK Q++Q +VS
Sbjct: 1676 EIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQG----LKLQHDQ-------RVS 1724
Query: 693 QIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQ 752
+++ K Q +L+ +L +N Q S + ++ Q + + R + EIE + LQS
Sbjct: 1725 ELE--KTQVAVLEEKLELENLQQISQQQKGEIEW-QKQLLERDKREIERMTAESRALQSC 1781
Query: 753 LT----EKDSMIENM-----KSSQTS---GTNEQSSAIVSARDSE---QVAELKQELATL 797
+ EK+ + E K +QT E++S + + + V +L+QEL L
Sbjct: 1782 VECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQL 1841
Query: 798 KSQLNSQSVEITKLQTEKQELLQKTEAFAKSV-EVQ-----GETETIIATKTTDVEGRLS 851
S +I+ +Q + QE + + + + VQ + + + TK DV
Sbjct: 1842 NRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDV----- 1896
Query: 852 ALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLV 911
LL E L+ +I + +++ ++ + +LQ E ++ +L++ + L
Sbjct: 1897 -LLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQK 1955
Query: 912 LLADQDQKILSLKNKLKDLGHPVEEE 937
++ K+ + K LK+ H +E+E
Sbjct: 1956 ERESEESKLETSKVTLKEQQHQLEKE 1981
Score = 49.3 bits (116), Expect = 2e-05
Identities = 72/369 (19%), Positives = 166/369 (44%), Gaps = 41/369 (11%)
Query: 614 TKLVKELEGVITKAIYKSSEEDKKE-EEVKKTLEQHDNIV----THYKNMIREQDLQLEE 668
T+ +K+LE +T+ ++E KK+ E V L+++ + T +N R+ + E
Sbjct: 589 TEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKET 648
Query: 669 LRQQVSTLKCQNEQLQTA------VTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGA 722
L Q+++ ++ + +QL+ + +++++++ + + + L + +Y
Sbjct: 649 LLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAEL 708
Query: 723 QMN-GIQPEEIGRLREEIEELKR----NQELLQSQLTEKDSMIEN-MKSSQTSGTNEQSS 776
+ ++ E +L+EE+E++ R Q LQ++L ++ ++N + +Q S EQ +
Sbjct: 709 EARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQEN 768
Query: 777 AIVSAR-----DSEQVAELKQELATLKSQLN---SQSVEITKLQTEKQELLQKTEAFAKS 828
+ + A+ D + LKQ+L ++ LN V ++ EL +K +
Sbjct: 769 SELHAKLKHLQDDNNL--LKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGE 826
Query: 829 VEVQGETETIIATKTTDVEGRLSALLQETKELKNEI----KALSEERTAIKEQLDSSNST 884
+ + ++ ++ D++ + S +L +K ++E + L EE +E+L +
Sbjct: 827 MNIHSPSD-VLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEE 885
Query: 885 IAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGD 944
Q + LE + K++ + + + +I L+ LK + EE L
Sbjct: 886 FR--QACERALEARMNFDKRQHE---ARIQQMENEIHYLQENLKSM----EEIQGLTDLQ 936
Query: 945 QEDEDDESE 953
++ D+E E
Sbjct: 937 LQEADEEKE 945
Score = 48.5 bits (114), Expect = 3e-05
Identities = 80/437 (18%), Positives = 189/437 (43%), Gaps = 61/437 (13%)
Query: 524 GQIAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGF 583
GQIA N E L + L ++ G+ Y +++ + + + R KE +++L
Sbjct: 602 GQIAAN----EALKKDLEGVISGLQEYLG--TIKGQATQAQNECRKLRDEKETLLQRLTE 655
Query: 584 ISKH----ELYSRASQKPQPNFPSPEYMIFD-HEFTKLVKELEGVITKAIYKSSEE---- 634
+ + E+ + ++ + E + + HE +++ +G ++ Y++ E
Sbjct: 656 VEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSA--YEAELEARLN 713
Query: 635 --DKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQ-NEQLQTAVTQQV 691
D + ++K+ LE+ + T + + +L+ E + + K Q +E+ + ++
Sbjct: 714 LRDAEANQLKEELEKVTRL-TQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELH 772
Query: 692 SQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQS 751
++++ +D NLLK QL H +G ++PEE+ ++EL+R +L
Sbjct: 773 AKLKHLQDDNNLLKQQLKDFQNHLNHVVDGL----VRPEEVAA---RVDELRRKLKL--- 822
Query: 752 QLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATL--KSQLNSQSVEIT 809
GT E + S + +A+L+++ + + +S+ ++
Sbjct: 823 ------------------GTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR 864
Query: 810 KLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSE 869
+ + +++ LQ+ + E + E + + + + A +Q+ ++NEI L E
Sbjct: 865 ERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQ---MENEIHYLQE 921
Query: 870 ERTAIKEQLDSSNSTIAILQTEKDKL--ELEITDSKKEQDDLLVLLADQDQKILSLKNKL 927
+++E ++ + EK+++ +L + KK+ +D A +++ L +L
Sbjct: 922 NLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLED-----AKSQEQVFGLDKEL 976
Query: 928 KDLGHPVEEEDELESGD 944
K L V D+L + +
Sbjct: 977 KKLKKAVATSDKLATAE 993
Score = 48.5 bits (114), Expect = 3e-05
Identities = 93/400 (23%), Positives = 166/400 (41%), Gaps = 56/400 (14%)
Query: 555 SLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFT 614
SL + + +QL EKR + E+L + H + A Q + ++ E T
Sbjct: 1847 SLHNDISAMQQQLQEKREAVNSLQEELANVQDH--LNLAKQDLLHTTKHQDVLL--SEQT 1902
Query: 615 KLVKELEGVITKAIYKSSEEDKKEEEVKKT-LEQHDNIVTHYKNMIREQDLQLEELRQQV 673
+L K++ + E+ +KEEE K+ L+ N + K + +Q++ + L+++
Sbjct: 1903 RLQKDISEWANRF-----EDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKER 1957
Query: 674 S-----------TLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGA 722
TLK Q QL+ +T Q S++ Q + L + + Q + + E
Sbjct: 1958 ESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKV-LAAEERVRTLQEEERWCESL 2016
Query: 723 QMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSAR 782
+ Q + RE+ + ++++ ELL Q E DSM + + E+ A
Sbjct: 2017 EKTLSQTKRQLSEREQ-QLVEKSGELLALQ-KEADSMRADFSLLRNQFLTERKKA----- 2069
Query: 783 DSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATK 842
+QVA LK+ L +SQL +E Q ++ +QK A + V K
Sbjct: 2070 -EKQVASLKEALKIQRSQLEKNLLE----QKQENSCIQKEMATIELVAQDNHERARRLMK 2124
Query: 843 TTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDS 902
L+ + E ELK K ++ ++ + Q++ S++ ++T K +++ EI S
Sbjct: 2125 ------ELNQMQYEYTELK---KQMANQKDLERRQMEISDA----MRTLKSEVKDEIRTS 2171
Query: 903 KKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELES 942
K + L L + IL L E ELES
Sbjct: 2172 LKNLNQFLPELPADLEAILERNENL---------EGELES 2202
Score = 42.7 bits (99), Expect = 0.002
Identities = 75/384 (19%), Positives = 158/384 (41%), Gaps = 20/384 (5%)
Query: 589 LYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQH 648
L S S + QP F+ + V+ LE + K + ++ E K+ + ++
Sbjct: 244 LRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQ 303
Query: 649 DNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQL 708
D + K Q EEL+ ++T +Q +T+ + + + + KI
Sbjct: 304 DKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDA 363
Query: 709 GKD--NQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSS 766
+ N + Y+E + P IG+ R KRN +S + + ++ K
Sbjct: 364 KFEPLNYYPSEYAEIDKAPDESPY-IGKSR-----YKRNMFATESYIIDSAQAVQIKKME 417
Query: 767 QTSGT-NEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAF 825
N+ + Q+ + +++++ +++L+ EI K + Q++L+ TE F
Sbjct: 418 PDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSELHDEIEKAE---QQILRATEEF 474
Query: 826 AK---SVEVQGETETIIATKTTDVEGRL---SALLQETKELKNEIKALSEERTAIKEQLD 879
+ +++++ +E + GRL + L QE +L+ +++ +E ++++
Sbjct: 475 KQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIK 534
Query: 880 SSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILS-LKNKLKDLGHPVEEED 938
I L + KD + K ++ L ++ Q Q++ S L L + EE
Sbjct: 535 DLQIAIDSLDS-KDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIK 593
Query: 939 ELESGDQEDEDDESEDPGKDLDHI 962
+LE E + +E KDL+ +
Sbjct: 594 DLEEQLTEGQIAANEALKKDLEGV 617
Score = 38.9 bits (89), Expect = 0.023
Identities = 54/280 (19%), Positives = 120/280 (42%), Gaps = 26/280 (9%)
Query: 671 QQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQ--MNGIQ 728
Q +S LK + + + + H Q+ + ++ + + Q ++ Q
Sbjct: 209 QDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFS 268
Query: 729 PEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVA 788
EE+ RL ++E+ E L+S+ T +E +K+ + + A++ + E
Sbjct: 269 LEEVERLERDLEKKMIETEELKSKQTR---FLEEIKNQDKLNKSLKEEAMLQKQSCE--- 322
Query: 789 ELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEG 848
ELK +L T L +++E+T+ +KQ L++ AF K ++ + E ++ +++
Sbjct: 323 ELKSDLNTKNELLKQKTIELTR-ACQKQYELEQELAFYK-IDAKFEPLNYYPSEYAEIDK 380
Query: 849 R--LSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQ 906
S + +++ +N A + + S + I + E D+ + +
Sbjct: 381 APDESPYIGKSRYKRNMF--------ATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGH 432
Query: 907 DDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQE 946
L L D+++KI + + +L +L DE+E +Q+
Sbjct: 433 TPLDTQLEDKEKKISAAQTRLSEL------HDEIEKAEQQ 466
Score = 36.2 bits (82), Expect = 0.15
Identities = 43/197 (21%), Positives = 87/197 (44%), Gaps = 24/197 (12%)
Query: 612 EFTKLVKELEGVITKAIYKSSEEDKK------EEEVKKTLEQHDNIVTHYKNMIREQDLQ 665
E K ++E++G+ + ++ EE ++ E E KK LE + + + D +
Sbjct: 921 ENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKS-----QEQVFGLDKE 975
Query: 666 LEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMN 725
L++L++ V+T +++L TA ++ KDQ L + K NQ + + A+
Sbjct: 976 LKKLKKAVAT----SDKLATA------ELTIAKDQLKSLHGTVMKINQERAEELQEAERF 1025
Query: 726 GIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSE 785
+ + R ++ + ELLQ+ L +K GT S + + +E
Sbjct: 1026 SRKAAQAAR---DLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNE 1082
Query: 786 QVAELKQELATLKSQLN 802
+ + E+A L++ L+
Sbjct: 1083 TMERQRTEIARLQNVLD 1099
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 66.6 bits (161), Expect = 1e-10
Identities = 73/351 (20%), Positives = 165/351 (47%), Gaps = 32/351 (9%)
Query: 630 KSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQ---DLQLEELRQQVSTLKCQN---EQL 683
++SE +++ ++KKTL+ N+ +++ +E D + ELR+ V +LKC + QL
Sbjct: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
Query: 684 QTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYS----EGAQMNGI---QPEEIGRLR 736
Q + S+ +Q K LLK K + + SY E ++ ++I +L
Sbjct: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Query: 737 EEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAE----LKQ 792
E+++L+ + LQ L E + ++ + + + +D +Q+ + L+Q
Sbjct: 784 SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843
Query: 793 ELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSV----EVQGETETIIATKTTDVEG 848
+ + L +V+I L+ E + L ++ + +S E++ E + ++ T D++
Sbjct: 844 QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKT 903
Query: 849 RLSA---LLQE---TKELKNEIKALSEERTAI---KEQL--DSSNSTIAILQTEKDKLEL 897
++ L+ E T+++ N+++ L+ E I KE+L D ++ + + + KLE
Sbjct: 904 LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLES 963
Query: 898 EITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDE 948
+ S + +++ + L + ++ + +L+ V++ E Q++E
Sbjct: 964 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEE 1014
Score = 60.5 bits (145), Expect = 7e-09
Identities = 68/321 (21%), Positives = 143/321 (44%), Gaps = 36/321 (11%)
Query: 636 KKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQ 695
+ E K LEQ + + + +R++ E R V ++ +N+ L ++ + S++
Sbjct: 547 ENSERQIKILEQENEHLNQTVSSLRQRSQISAEAR--VKDIEKENKILHESIKETSSKLS 604
Query: 696 QHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTE 755
+ + + K Q+ K+ +H E A+ L E+ L++ ELLQ ++T
Sbjct: 605 KIEFE----KRQIKKELEHYKEKGERAE----------ELENELHHLEKENELLQKKITN 650
Query: 756 KDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEK 815
E +++ + + + R++ ++ + L QL S E ++L E
Sbjct: 651 LKITCEKIEALEQENSELE-------RENRKLKKTLDSFKNLTFQLESLEKENSQLDEEN 703
Query: 816 QELLQKTE----AFAKSVEVQGETETIIATKTTDVEGR--LSALLQETKELKNEIKALSE 869
EL + E A K ++Q E + + + K +G L A ++T+ L+ + L
Sbjct: 704 LELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDI 763
Query: 870 ERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKD 929
E +++ L++SN I L++E LE+E +K ++L + +++ L+ + K
Sbjct: 764 ENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKI----SSKRLEQLEKENKS 819
Query: 930 LGHPVEEEDELESGDQEDEDD 950
L +E +LE ++ E +
Sbjct: 820 L---EQETSQLEKDKKQLEKE 837
Score = 53.5 bits (127), Expect = 9e-07
Identities = 77/381 (20%), Positives = 162/381 (42%), Gaps = 70/381 (18%)
Query: 610 DHEFTKLVKELEGVITKAIYKSSEEDKKEEE-VKKTLEQHDNIVTHYKNMIREQDLQLEE 668
+ E L KE+ G+ ++ + E +K+ +E VK+ +VT ++++ E+ L+ ++
Sbjct: 863 EKENKTLSKEI-GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEK-LKTQQ 920
Query: 669 LRQQVSTLKCQNEQLQTAVTQQVSQIQQHKD-QYNLLKIQLGKDNQHQGSYSEGAQMNGI 727
+ + L + E++ + + Q D +Y LL+ +L + + + + I
Sbjct: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKL------ESTLKKSLE---I 971
Query: 728 QPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDS--- 784
+ E+I L +EE + L+ +L E +K Q QSS +S D+
Sbjct: 972 KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE 1031
Query: 785 --------------EQVAELKQELATLKSQLNSQSVEITKLQTEKQELL----------- 819
+++ E+++ ATL+++ + ++ +L+T+ L
Sbjct: 1032 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1091
Query: 820 ----QKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIK 875
Q T ++ ++Q E T+ + T+ + L+Q++ L+NE +++ +ER +K
Sbjct: 1092 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS-SLENENESVIKEREDLK 1150
Query: 876 EQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVL-----------------LADQDQ 918
DS L + +KLEL E + L+ L D+
Sbjct: 1151 SLYDS-------LIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1203
Query: 919 KILSLKNKLKDLGHPVEEEDE 939
++L K +L+DL ++ E E
Sbjct: 1204 QLLKQKGQLEDLEKMLKVEQE 1224
Score = 43.9 bits (102), Expect = 7e-04
Identities = 88/437 (20%), Positives = 178/437 (40%), Gaps = 108/437 (24%)
Query: 610 DHEFTKLVKELEGVITKAIYKSSEE--------DKKEEEVKKTLEQHDNIVTHYKNMIRE 661
+ E +L K LE + KA +K +E D + + ++KTLE + + ++ +++
Sbjct: 731 ESEKEQLKKGLE--LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQD 788
Query: 662 QDLQ-----------------LEELRQQVSTLKCQNEQLQTAVTQ---------QVSQIQ 695
+++ LE+L ++ +L+ + QL+ Q Q ++I+
Sbjct: 789 LEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIK 848
Query: 696 QHKDQYNLLKI-QLGKDN----QHQGSYSEG-AQMNGIQPE------------------- 730
+ N +KI L K+N + G Y E ++ ++ E
Sbjct: 849 DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR 908
Query: 731 ---------------EIGRLREEIEELKRNQE-LLQSQLTEKDSMIENMKSSQTS----- 769
++ +L E+E++ N+E LL + + DS + ++S S
Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKS 968
Query: 770 -GTNEQSSAIVSARDSEQV---AELKQELATLKSQLNSQ----------------SVEIT 809
E+ A + AR E +L+QEL T+K + S E
Sbjct: 969 LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN 1028
Query: 810 KLQTEKQELLQK-TEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALS 868
K + E QE ++ + + +EV+ T+ A K ++ +L L + L+ +I AL
Sbjct: 1029 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQA-LKTQLKQLETQNNNLQAQILALQ 1087
Query: 869 EERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLV---LLADQDQKILSLKN 925
+ +++EQ + + A LQ E L + T + LL+ L ++++ ++ +
Sbjct: 1088 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1147
Query: 926 KLKDL-GHPVEEEDELE 941
LK L +++ ++LE
Sbjct: 1148 DLKSLYDSLIKDHEKLE 1164
Score = 42.7 bits (99), Expect = 0.002
Identities = 81/329 (24%), Positives = 137/329 (41%), Gaps = 56/329 (17%)
Query: 443 ALAHALQENATQKEQLLRVQLATSIGNPPVSLLQQCTNILSQGSKIQTRVGLLMLLCTWL 502
AL L++ TQ L LA + VSL +Q T + +Q +K+Q L T L
Sbjct: 1064 ALKTQLKQLETQNNNLQAQILA--LQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL 1121
Query: 503 SNCPIAVTHFLHNSANVPFLTGQIA-ENLGEEEQLVQGLCALLLGISIYFNDNSLESYMK 561
N N L Q + EN E E +++ L S+Y D+ ++ +
Sbjct: 1122 MN------------QNAQLLIQQSSLEN--ENESVIKEREDLK---SLY--DSLIKDH-- 1160
Query: 562 EKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELE 621
EKL+ L E++ E ISKH A + + E+ + + +L+K+
Sbjct: 1161 EKLELLHERQAS-----EYESLISKHGTLKSAHKNLE-----VEHRDLEDRYNQLLKQ-- 1208
Query: 622 GVITKAIYKSSEEDKKEEEVKKTLE--QHDNIVTHYKNMIREQDL---QLEELRQQVSTL 676
K + E+ K E+ K LE H+ + YK + E D +L ++ L
Sbjct: 1209 ----KGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1264
Query: 677 KCQNEQLQTAV-------TQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQP 729
+ ++ L++ + T+ ++ + K+QY L I K N S Q+ G
Sbjct: 1265 QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLS---QLKGNLE 1321
Query: 730 EEIGRLREEIEELK-RNQELLQSQLTEKD 757
EE L ++I+ L +N+ LL+ + KD
Sbjct: 1322 EENRHLLDQIQTLMLQNRTLLEQNMESKD 1350
Score = 40.8 bits (94), Expect = 0.006
Identities = 54/277 (19%), Positives = 131/277 (47%), Gaps = 34/277 (12%)
Query: 645 LEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLL 704
L Q ++ +++I+E+ E+L+ +L +E+L+ +Q S+ + ++ L
Sbjct: 1129 LIQQSSLENENESVIKER----EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTL 1184
Query: 705 KIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMK 764
K + H+ E + + ++ + + ++E+L++ ++ Q ++ ++ E +
Sbjct: 1185 K------SAHKNLEVEHRDLED-RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1237
Query: 765 SS--QTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKT 822
+ + G N++ + S E L+ + LKS LN+ +E T+L+ E +L ++
Sbjct: 1238 AEYKKLCGENDRLNHTYSQLLKETEV-LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQY 1296
Query: 823 EAF-AKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALS-EERTAIKEQLDS 880
+ S ++ + E + + ++G L +E + L ++I+ L + RT +++ ++S
Sbjct: 1297 QQLDITSTKLNNQCELL-----SQLKGNLE---EENRHLLDQIQTLMLQNRTLLEQNMES 1348
Query: 881 SN----------STIAILQTEKDKLELEITDSKKEQD 907
+ + L+ +K+KLE +I D K D
Sbjct: 1349 KDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYD 1385
Score = 39.7 bits (91), Expect = 0.014
Identities = 74/321 (23%), Positives = 132/321 (41%), Gaps = 63/321 (19%)
Query: 635 DKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLE---ELRQQVSTLKCQNEQLQTAVTQQV 691
D +E+++ L+ N+ H K +I E+D E EL ++ L +A +
Sbjct: 180 DMSQEDIEPLLK---NMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCG 236
Query: 692 SQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQS 751
S + + L ++L +I RLR+E+EE + ++LL
Sbjct: 237 SPGMKRTESRQHLSVELADAKA-----------------KIRRLRQELEE--KTEQLLDC 277
Query: 752 QLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKL 811
+ E + M +K Q N S D+ + EL L+ ++V + KL
Sbjct: 278 K-QELEQMEIELKRLQQENMNLLS-------DARSARMYRDELDALR----EKAVRVDKL 325
Query: 812 QTE---KQELLQKTEAF-AKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKAL 867
++E +E L E + A+ E++ + + ++ TKT L L+ T+ +++ L
Sbjct: 326 ESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKT-----MLEDQLEGTRARSDKLHEL 380
Query: 868 SEERTAIKEQL-------DSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKI 920
+E +K +L D I L E LE+ K+ D+ L L + +Q
Sbjct: 381 EKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMA---QKQSMDESLHLGWELEQ-- 435
Query: 921 LSLKNKL-----KDLGHPVEE 936
+S ++L K LGH V E
Sbjct: 436 ISRTSELSEAPQKSLGHEVNE 456
Score = 38.9 bits (89), Expect = 0.023
Identities = 43/188 (22%), Positives = 82/188 (43%), Gaps = 26/188 (13%)
Query: 785 EQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTT 844
+++ E ++L K +L +E+ +LQ E LL + A+ + + A +
Sbjct: 265 QELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARS-ARMYRDELDALREKAVRVD 323
Query: 845 DVEGRLSALLQE----------TKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDK 894
+E +S + +ELK + + L E +T +++QL+ + + DK
Sbjct: 324 KLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT-------RARSDK 376
Query: 895 LELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESED 954
L + +KE L L D + + + K+++L +EE LE Q+ DES
Sbjct: 377 LH----ELEKENLQLKAKLHDMEMERDMDRKKIEEL---MEENMTLEMA-QKQSMDESLH 428
Query: 955 PGKDLDHI 962
G +L+ I
Sbjct: 429 LGWELEQI 436
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 66.6 bits (161), Expect = 1e-10
Identities = 109/515 (21%), Positives = 198/515 (38%), Gaps = 106/515 (20%)
Query: 510 THFLHNSANVPFLTGQIAENLGEEEQLVQGLCALLLG---ISIYFNDNSLESYMKEKLKQ 566
+H NS P A E+++ L +G + F DNS ++ ++LK
Sbjct: 226 SHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKA 285
Query: 567 LIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITK 626
++ K N +E + HE K Q N +F +L +LE +
Sbjct: 286 QNQELRNKINELELR--LQGHE----KEMKGQVN-----------KFQELQLQLEKAKVE 328
Query: 627 AIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEEL---RQQVSTLKCQNEQ- 682
I K +K +E+ +T Q+D T Y + ++ E+L RQ + +C EQ
Sbjct: 329 LIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQK 388
Query: 683 -------LQTAVTQQ------------------VSQIQQHKDQYNLLKIQLGK----DNQ 713
Q +++Q ++QQ K+ +N+L+ +L K Q
Sbjct: 389 IKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQ 448
Query: 714 HQGSYSEGAQM-----NGIQPEEI--GRLREEIEELKRNQELLQSQ-------------- 752
+ + E Q Q +I LR +EE+K+ LL+S
Sbjct: 449 LENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAE 508
Query: 753 -------LTEKDSMIENMKSSQTS----------GTNEQSSAIVSARDSEQVAELKQE-- 793
L + + E MK+ TS N+Q +++ + VA+L+++
Sbjct: 509 LKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRD 568
Query: 794 -----LATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEG 848
L + + + +++K + E + LL E K E E +T+ + ++ E
Sbjct: 569 CSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEK 628
Query: 849 RLSALLQETKELKNEIKALSEERTAIKEQLDSS---NSTIAILQTEKDKLELEITDSKKE 905
L+ + E + L+++I L T +K Q S N + L+ +++ L +EI +
Sbjct: 629 LLTQMESEKENLQSKINHL---ETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNV 685
Query: 906 QDDLLVLLADQDQKILSLKNK--LKDLGHPVEEED 938
D V + Q + L+ K D H E E+
Sbjct: 686 LDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIEN 720
Score = 63.9 bits (154), Expect = 7e-10
Identities = 69/296 (23%), Positives = 135/296 (45%), Gaps = 25/296 (8%)
Query: 656 KNMIREQDLQLEELRQQVSTLKCQNE---QLQTAVTQQVSQIQQHKDQY------NLLKI 706
+N + + LE +Q S L+ Q E Q++ + + + + +Q + + K+
Sbjct: 829 QNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKL 888
Query: 707 QLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIE-ELKRNQELLQSQLTEKDSMIENMKS 765
Q + HQ +E + +E+ L +++E E QEL +S +DS+ E
Sbjct: 889 Q-EDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLL 947
Query: 766 SQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAF 825
S+T ++ + + + + ++ EL QE TLK ++N+ L EK L+QK+E+F
Sbjct: 948 SETLSLEKKEMSSIISLNKREIEELTQENGTLK-EINA------SLNQEKMNLIQKSESF 1000
Query: 826 AKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDS----S 881
A ++ E E I+ + + LLQ +E N + LS++ A +E+
Sbjct: 1001 ANYID---EREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLL 1057
Query: 882 NSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEE 937
N ++ + K++LE KE + L LA +++ +L +L+ + + E
Sbjct: 1058 NECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSE 1113
Score = 61.6 bits (148), Expect = 3e-09
Identities = 80/367 (21%), Positives = 161/367 (43%), Gaps = 46/367 (12%)
Query: 605 EYMIFDH-EFTKLVKELEGV---ITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIR 660
EY DH E + V+ EG+ + KSS ED + K + +K
Sbjct: 1847 EYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAK--------VNDSWKERFL 1898
Query: 661 EQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSE 720
+ + +L +R + +++ ++E L +V Q + K+ L KDN+++
Sbjct: 1899 DVENELSRIRSEKASI--EHEALYLEADLEVVQTE---------KLCLEKDNENKQKVIV 1947
Query: 721 GAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVS 780
+ EE+ + E +L+ + + + T D + E MK + QS +
Sbjct: 1948 CLE------EELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHC 2001
Query: 781 ARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQ-------- 832
+ +E AE+K++ L++ L+S E+ K +T QE LQ E ++++ +
Sbjct: 2002 IQVAE--AEVKEKTELLQT-LSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQI 2058
Query: 833 ---GETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQ 889
+ + ++ ++ ++ RLS E + ++A E+ +L S+ + L+
Sbjct: 2059 AQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLR 2118
Query: 890 TEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPV---EEEDELESGDQE 946
+KL + I +K+Q + L +++++ SLK+K+++L + EE EL D E
Sbjct: 2119 RGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAE 2178
Query: 947 DEDDESE 953
+ E E
Sbjct: 2179 NSKAEVE 2185
Score = 59.7 bits (143), Expect = 1e-08
Identities = 85/450 (18%), Positives = 184/450 (40%), Gaps = 47/450 (10%)
Query: 522 LTGQIAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKL 581
LT QI E G+ +L + L + S+ E +KE+ K +E +N +++L
Sbjct: 2215 LTKQIQEKQGQLSELDKLLSSFK---SLLEEKEQAEIQIKEESKTAVEML---QNQLKEL 2268
Query: 582 G-----FISKHELYSRASQKPQPNFPSPEYMIFDHEFTKLVKELEGVITKAIYKSSEEDK 636
E+ Q P P E +H+ +++L + ++K
Sbjct: 2269 NEAVAALCGDQEIMKATEQSLDP--PIEE----EHQLRNSIEKLRA-------RLEADEK 2315
Query: 637 KEEEVKKTLEQHDNIVTHYKNMIR--EQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQI 694
K+ V + L++ ++ K + E++L++ Q+ + L+ +N + + + ++I
Sbjct: 2316 KQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLK--AKI 2373
Query: 695 QQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLT 754
+ L++ + + + + Q + E+ + E + + +E + Q+
Sbjct: 2374 EGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMK 2433
Query: 755 EKDSMIENMKSSQTSGTNEQSSAIVSARD---------SEQVAELKQELATLKSQLNSQS 805
EK S M +Q NE+ +A+ + ++ S QV L+ E A L L+
Sbjct: 2434 EKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAK 2493
Query: 806 VEITKLQTEKQELLQKTEAFAKSVEVQGET----------ETIIATKTTDVEGRLSALLQ 855
LQ+ L+Q+ E + +E + E + + +K + VEG +
Sbjct: 2494 NNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKE 2553
Query: 856 ETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLAD 915
+ EL+N L ++ ++ + S T+ +LQ+ LE E+ +K ++ + +
Sbjct: 2554 QNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNK 2613
Query: 916 QDQKILSLKNKLKDLGHPVEEEDELESGDQ 945
K L+ ++ ++ E E SG++
Sbjct: 2614 MTAKETELQREMHEMAQKTAELQEELSGEK 2643
Score = 57.0 bits (136), Expect = 8e-08
Identities = 63/305 (20%), Positives = 125/305 (40%), Gaps = 67/305 (21%)
Query: 616 LVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVST 675
L +E +I K+ ++ D++E+ + + +Q+ E E+L Q+
Sbjct: 986 LNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKA 1045
Query: 676 LKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRL 735
+ +N +L+ + + S + K++ LK K++Q
Sbjct: 1046 AQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQ---------------------- 1083
Query: 736 REEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELA 795
E + +L +E Q+ + E +++ + ++S T N S + LKQE+
Sbjct: 1084 -EFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKS---------EAGGLKQEIM 1133
Query: 796 TLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQ 855
TLK + N K+Q E +LLQ+ E K ++ + E + +
Sbjct: 1134 TLKEEQN-------KMQKEVNDLLQENEQLMKVMKTKHECQNL----------------- 1169
Query: 856 ETKELKNEIKALSEERT----------AIKE-QLDSSNSTIAILQTEKDKLELEITDSKK 904
E++ ++N +K ER +KE LDS N+ + L+ EL++ +S+K
Sbjct: 1170 ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEK 1229
Query: 905 EQDDL 909
E++ L
Sbjct: 1230 EKECL 1234
Score = 56.2 bits (134), Expect = 1e-07
Identities = 80/387 (20%), Positives = 164/387 (42%), Gaps = 55/387 (14%)
Query: 612 EFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQ 671
E T+ ++ + I + E K++ E+ +TL + + K ++E+ LE+ Q
Sbjct: 1986 EKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQ 2045
Query: 672 QVSTLKCQNEQLQTAVTQQVSQIQQHKD----QYNLLKIQLGKDNQHQGSYSEGAQMNGI 727
+S KC+ E Q++Q+ + K+ + L+ +L + + + + S+ + +
Sbjct: 2046 ALSLTKCELEN-------QIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALV 2098
Query: 728 QP-----------EEIGRLREEIEELKRN-----------QELLQSQLTEKDSM---IEN 762
+ EE+ +LR IE+L+ E L+ + E DS+ +EN
Sbjct: 2099 EKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVEN 2158
Query: 763 MKSSQTSGTNEQSSAIVSARDSE--------QVAELKQ-------ELATLKSQLNSQSVE 807
++ Q I+ A +S+ Q+ E+ + +L TL+S+ + + +
Sbjct: 2159 LERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQ 2218
Query: 808 ITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKAL 867
I + Q + EL + +F +E + + E I ++ L L+E E +
Sbjct: 2219 IQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGD 2278
Query: 868 SEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKL 927
E A ++ LD L+ +KL + +K+Q +L L + + LK ++
Sbjct: 2279 QEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRV 2338
Query: 928 KDLGHPVEEEDELESGDQEDEDDESED 954
++L E E E+ +QE E+E+
Sbjct: 2339 ENL----ERELEIARTNQEHAALEAEN 2361
Score = 48.5 bits (114), Expect = 3e-05
Identities = 65/309 (21%), Positives = 128/309 (41%), Gaps = 66/309 (21%)
Query: 612 EFTKLVK-ELEGVITKAIYKSSEEDKKEEEV-KKTLEQHDNIVTHYKNMIREQDLQLEEL 669
E TK+ K + K K +E ++ E+ +KT E + + + E L LEE+
Sbjct: 2598 ELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEI 2657
Query: 670 ---RQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNG 726
+ Q+ L +N +L+ ++ HKDQ
Sbjct: 2658 KSSKDQLKELTLENSELKKSLD------CMHKDQV------------------------- 2686
Query: 727 IQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQ 786
E+ G++REEI E Q +L E E + TN+Q +
Sbjct: 2687 ---EKEGKVREEIAE-------YQLRLHE----AEKKHQALLLDTNKQYEV--------E 2724
Query: 787 VAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETE-------TII 839
+ +++L + + L+SQ +EI L++ K+EL +A + +E +T+ +
Sbjct: 2725 IQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQL 2784
Query: 840 ATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEI 899
+ +G++ L++ K+L+ E + L +E + + + T ++ T+ D+L EI
Sbjct: 2785 KKENERAQGKMKLLIKSCKQLEEEKEILQKELSQL-QAAQEKQKTGTVMDTKVDELTTEI 2843
Query: 900 TDSKKEQDD 908
+ K+ ++
Sbjct: 2844 KELKETLEE 2852
Score = 47.8 bits (112), Expect = 5e-05
Identities = 74/328 (22%), Positives = 134/328 (40%), Gaps = 46/328 (14%)
Query: 619 ELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKC 678
E G+ + + E++K ++EV L++++ ++ K Q+L+ E +R V +
Sbjct: 1124 EAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERES 1183
Query: 679 QNEQLQTAVTQQVSQIQQHKDQYNLLKIQL-----GKDNQHQGSYSEGAQMNGIQPEEIG 733
+ Q + + D YN +QL K+ + Q S E + E+
Sbjct: 1184 ERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQ----HELQ 1239
Query: 734 RLREEIEELKRNQELLQSQLTE--KDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELK 791
+R ++E N + +QSQ KD I+ + SG +E S+ S D+ A L+
Sbjct: 1240 TIRGDLE--TSNLQDMQSQEISGLKDCEID-AEEKYISGPHELST---SQNDN---AHLQ 1290
Query: 792 QELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLS 851
L T ++LN LQ EK EL+ + +E I AT+
Sbjct: 1291 CSLQTTMNKLNELEKICEILQAEKYELVTELN--------DSRSECITATR--------- 1333
Query: 852 ALLQETKELKNEIKALSEERTAIKEQL--DSSNSTIAILQTEKDKLELEITDSKKEQDDL 909
+ +E +L NE+K L+++ + +L D E+ + L D + L
Sbjct: 1334 KMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHL 1393
Query: 910 LVL-------LADQDQKILSLKNKLKDL 930
+ A+ +K LSL+++ K L
Sbjct: 1394 TLSDKEVQMHFAELQEKFLSLQSEHKIL 1421
Score = 45.8 bits (107), Expect = 2e-04
Identities = 87/455 (19%), Positives = 180/455 (39%), Gaps = 99/455 (21%)
Query: 555 SLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMIFDHEFT 614
++ + ++ +L +L + EN +E+ K +L RA Q Q + I ++E
Sbjct: 430 NMHNVLQAELDKLTSVKQQLENNLEEF----KQKL-CRAEQAFQAS------QIKENELR 478
Query: 615 KLVKELEGVITKAIYKSSEEDKKEE---------EVKKTLEQHDNIVTHYKNMIREQDLQ 665
+ ++E++ + KS E K E +K+ L Q N K Q+
Sbjct: 479 RSMEEMKK--ENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETM 536
Query: 666 LEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKD-QYNLLKIQLGKDNQHQGSYSEGAQM 724
L +L+++++ + +N + V+ +++ +D +LLK + Q S+ +
Sbjct: 537 LRDLQEKIN--QQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKE 594
Query: 725 NGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNE--------QSS 776
+ + ++E EELK + L +E + ++ M+S + + ++ ++
Sbjct: 595 SKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQ 654
Query: 777 AIVSARDSEQVAELKQ-------ELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSV 829
I S +E+V L+ E+ L + L+S+SVE+ + EL QK E +
Sbjct: 655 QIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKH 714
Query: 830 EVQGETETIIATKTT----DVEGRLSALLQET-------KELKNEIKALSE--------- 869
+ + E + ++ T D+E +L L E ++L E ++L +
Sbjct: 715 QKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASL 774
Query: 870 -----------------------------------ERTAIKEQLDSSNSTIAILQTEKDK 894
ER+ + + D S AILQ D
Sbjct: 775 VTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDS 834
Query: 895 LELEITDSKKEQDDLLVLLADQDQKILSLKNKLKD 929
LE + K+ D L Q ++++ +K ++++
Sbjct: 835 LEFSLESQKQMNSD----LQKQCEELVQIKGEIEE 865
Score = 45.4 bits (106), Expect = 2e-04
Identities = 71/364 (19%), Positives = 152/364 (41%), Gaps = 60/364 (16%)
Query: 621 EGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQN 680
EG+ T+A+ K E + + +++KK +Q + + +++Q ++E + + + LK +N
Sbjct: 10 EGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKREN 69
Query: 681 EQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIE 740
++L + + + + +Q + L+++ + N +G + G + +E+ R + E+E
Sbjct: 70 QRLM-EICESLEKTKQKIS--HELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELE 126
Query: 741 ELKRNQELLQS--------QLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQ 792
R+Q+ QS +K S SG+ + ++ E+ L+
Sbjct: 127 ---RSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEA 183
Query: 793 ELATLKSQLNSQSV--------EITKLQTEKQEL---LQKTEAFAKSVE----------- 830
E+ L+++ SQ++ +I + Q +KT + S
Sbjct: 184 EVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSA 243
Query: 831 --VQGETETIIATKTTDVEGR---------------LSALLQETKELKNEIKALSEERTA 873
GE E + T + R L L + +EL+N+I L
Sbjct: 244 SYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQG 303
Query: 874 IKEQLDSSNSTIAILQTEKDKLELEITDSKKE----QDDLLVLLADQDQ---KILSLKNK 926
++++ + LQ + +K ++E+ + +K +D+L+ A DQ K +L+ K
Sbjct: 304 HEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQK 363
Query: 927 LKDL 930
LK L
Sbjct: 364 LKKL 367
Score = 40.8 bits (94), Expect = 0.006
Identities = 45/236 (19%), Positives = 105/236 (44%), Gaps = 17/236 (7%)
Query: 730 EEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDS-EQVA 788
E+I L+ ++E L + ++D +E++ + ++ V E
Sbjct: 1767 EDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACI 1826
Query: 789 ELKQELATLKSQLNSQSVEITKLQTEKQELLQK---TEAFAKSVEVQGETETIIATKTTD 845
EL++ + LK + + S ++ + QELLQ+ +E +E+ + + D
Sbjct: 1827 ELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHAD-----KSSRED 1881
Query: 846 VEGRLSALLQETKE----LKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITD 901
+ ++ + KE ++NE+ + E+ +I+ + + + ++QTEK LE + +
Sbjct: 1882 IGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNEN 1941
Query: 902 SKKE----QDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESE 953
+K +++L V+ ++++Q L K + ++++ QE E +SE
Sbjct: 1942 KQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSE 1997
Score = 38.5 bits (88), Expect = 0.031
Identities = 32/111 (28%), Positives = 57/111 (51%), Gaps = 7/111 (6%)
Query: 847 EGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDS---K 903
EG + LQ+ +EL+ ++ L +E+ + QLDS A LQ +K K+E E T+ K
Sbjct: 10 EGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLE---AALQKQKQKVENEKTEGTNLK 66
Query: 904 KEQDDLLVLLADQDQKILSLKNKLKDLGHPVE-EEDELESGDQEDEDDESE 953
+E L+ + ++ + ++L+ V +E +L SG ++ E E E
Sbjct: 67 RENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQE 117
Score = 38.1 bits (87), Expect = 0.040
Identities = 54/234 (23%), Positives = 96/234 (41%), Gaps = 45/234 (19%)
Query: 737 EEIEELKRNQELLQSQLTEKD-------SMIENMKSSQTSGTNEQSSAIVSARDSEQVAE 789
+EI+EL ++LL S+ E D S E + TS T E S + + + +
Sbjct: 1579 KEIQEL---EQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLS 1635
Query: 790 LKQELATLKSQ-LNSQSVEITKLQTE-------------KQELLQKTEAFAK-------- 827
L+ E+A L+ Q L+ S + + TE K+ + TE K
Sbjct: 1636 LELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICD 1695
Query: 828 -------SVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDS 880
+++++ TET T + G S E E K +
Sbjct: 1696 KDAQQDLNLDIEKITETGAVKPTGECSGEQSP--DTNYEPPGEDKTQGSSECISELSFSG 1753
Query: 881 SNSTIAI--LQTEKD--KLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDL 930
N+ + + L ++D L+L + ++ E LL ++ D+D+K+ SL N++K+L
Sbjct: 1754 PNALVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKEL 1807
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 66.6 bits (161), Expect = 1e-10
Identities = 80/357 (22%), Positives = 159/357 (44%), Gaps = 44/357 (12%)
Query: 624 ITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQL 683
+TK + K + + E+E+++ E+ + +I DL++ +L++++ LK Q+
Sbjct: 1231 VTKEVIKYKTDPEMEKELQRLREE----IVDKTRLIERCDLEIYQLKKEIQALKDTKPQV 1286
Query: 684 QT-AVTQQVSQIQ---QHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEI 739
QT V Q++ Q Q Q K++ L+ +L ++ + Q + Q E+I R EE+
Sbjct: 1287 QTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLE---RERASQEEQIARKEEEL 1343
Query: 740 EELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSE--QVAELKQELATL 797
+K E+ E ++ + G ++SA + D E Q+ +L+ EL L
Sbjct: 1344 SRVK-----------ERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRL 1392
Query: 798 KSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQET 857
+ + ++ +L+ E+Q + EA EVQ + + A + + E R +
Sbjct: 1393 QRRRTELERQLEELERERQ---ARREA---EREVQRLQQRLAALEQEEAEAR-EKVTHTQ 1445
Query: 858 KELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLA--- 914
K + + + E ++ QL+ +L+ E + L ++ +K + V+L+
Sbjct: 1446 KVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELETLRRKLAALEKAEVKEKVVLSESV 1505
Query: 915 -----DQDQKILSLKNKLKDLGHPVEEED----ELESGDQEDEDDESEDPGKDLDHI 962
D +Q+I LK+ L++ E D LE+ E E S+ K+LD +
Sbjct: 1506 QVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKS-SKELDFL 1561
Score = 59.3 bits (142), Expect = 2e-08
Identities = 81/413 (19%), Positives = 173/413 (41%), Gaps = 39/413 (9%)
Query: 560 MKEKLKQLIEKRIGKENFIEKLG---FISKHELYSRASQKPQPNFPSPEYMIFDHEFTKL 616
M+++L++L E+ + K IE+ + K E+ + KPQ I +
Sbjct: 1244 MEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKPQVQTKEVVQEILQFQEDPQ 1303
Query: 617 VKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYK---NMIREQDLQLEELR-QQ 672
KE + K SEE KK+ ++++ + + + + ++E+ +Q E +R ++
Sbjct: 1304 TKE---EVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEE 1360
Query: 673 VSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEI 732
L+ + ++ ++ QI + + + L+ + + + Q E+
Sbjct: 1361 EPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREV 1420
Query: 733 GRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAE--- 789
RL++ + L++ + + ++T ++ Q + + Q+ E
Sbjct: 1421 QRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGEL 1480
Query: 790 --LKQELATL-KSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDV 846
L+++LA L K+++ + V +Q EK + Q+ + S+E + ++ + + + +
Sbjct: 1481 ETLRRKLAALEKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRL 1540
Query: 847 EGRLSALLQETKELKNEIKALSEERTAIKEQLDSSN---------STIAILQTE-KDKLE 896
E RLS L + E+ L EE K QL+ N S I + TE +D
Sbjct: 1541 EARLSELEFHNSKSSKELDFLREENH--KLQLERQNLQLETRRLQSEINMAATETRDLRN 1598
Query: 897 LEITDS-----------KKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEED 938
+ + DS ++E DDL L D+D +I L+ +L + E+ +
Sbjct: 1599 MTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQKRLGSVAVKREQRE 1651
Score = 50.1 bits (118), Expect = 1e-05
Identities = 91/456 (19%), Positives = 194/456 (42%), Gaps = 57/456 (12%)
Query: 526 IAENLGEEEQLVQGLCALLLGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFIS 585
+ + + EQ VQ +CA D LE+ EKL+ L++ G+ + + K +
Sbjct: 773 LLDEIASREQEVQKICANSQQYQQAVKDYELEA---EKLRSLLDLENGRSSHVSKRARLQ 829
Query: 586 KH----------------ELYSRASQKPQP-----NF--PSPEYMIFDHEFTKLVKELEG 622
E+Y+ Q+ Q N PE + HE + + G
Sbjct: 830 SPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV-THETLQRNRPDSG 888
Query: 623 V-----ITKAIYKSSEEDKK-EEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVS-- 674
V I K + + +E ++ E EVK T E+ + +N ++ + +E+ ++V
Sbjct: 889 VEEAWKIRKELDEETERRRQLENEVKSTQEE----IWTLRNQGPQESVVRKEVLKKVPDP 944
Query: 675 TLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLG---KDNQHQGSYSEGAQMNGIQPE- 730
L+ +QLQ + ++ + Q +++ L++QL ++ + G ++ I+P+
Sbjct: 945 VLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDR 1004
Query: 731 ----EIGRLREEIEELKRNQELLQSQL----TEKDSMIENMKSSQTSGTNEQSSAIVSAR 782
E+ +LREE+E L+R + ++++ ++ E +Q T ++ + +
Sbjct: 1005 AQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRAQEKVTEKEVVKLQNDP 1064
Query: 783 DSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAK-SVEVQGETETIIAT 841
E + QE + QL + E +K + L+K A A+ + V+ E +
Sbjct: 1065 QLEAEYQQLQEDHQRQDQLREKQEEELSFLQDKLKRLEKERAMAEGKITVK---EVLKVE 1121
Query: 842 KTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITD 901
K E +S L ++ ++ + +A E+T + ++ + A + ++ E+ D
Sbjct: 1122 KDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPD 1181
Query: 902 SKKEQD--DLLVLLADQDQKILSLKNKLKDLGHPVE 935
K E + +L + L +Q++K + +L+ +E
Sbjct: 1182 PKAESEVANLRLELVEQERKYRGAEEQLRSYQSELE 1217
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 66.2 bits (160), Expect = 1e-10
Identities = 90/462 (19%), Positives = 196/462 (42%), Gaps = 65/462 (14%)
Query: 545 LGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSP 604
+G +Y S ++EK K+ + + + EK + +Y ++K +
Sbjct: 139 IGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKC---HRRTVYELENEKHKHT---- 191
Query: 605 EYMIFDHEFTKLVKELEGVITKAIY--KSSEEDKKEEEVKKTLEQHDNIV---THYKNMI 659
+YM +FT L+++ + K + K+ + K++E K+ + D +V + ++
Sbjct: 192 DYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLV 251
Query: 660 REQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHK-DQYNLLKIQLGKDNQHQGSY 718
E+ + +E+L Q ++ ++L+ + + + K D+ LLK+++ +++
Sbjct: 252 DERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFS 311
Query: 719 SEGAQMNGIQPEEIGRLR-------------EEIEELKRNQELLQSQLTE-KDSM----- 759
E +MN + R EE+EE +N + + +L E +D +
Sbjct: 312 QEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGEC 371
Query: 760 --------IENMKSS--QTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEIT 809
+EN++ + G +E+ + + Q EL+++L + +E+
Sbjct: 372 GNSSLMAEVENLRKRVLEMEGKDEEIT-----KTESQCRELRKKLQEEEHHSKELRLEVE 426
Query: 810 KLQTEKQELLQKTEAFAKSVEVQGETETIIATK---TTDVEGRLSALLQETKELKNEIKA 866
KLQ EL + EAF+KS + + + T D+ L + KEL+
Sbjct: 427 KLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESR 486
Query: 867 LSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQD--------------DLLVL 912
L + ++K+ L S +L E+ + +I +++ D D+
Sbjct: 487 LEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEK 546
Query: 913 LADQDQKILSLKNKLKD-LGHPVEEEDELESGDQEDEDDESE 953
L ++ +K+L LK+++++ + + E DEL + +E+ SE
Sbjct: 547 LIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSE 588
Score = 52.8 bits (125), Expect = 2e-06
Identities = 77/364 (21%), Positives = 162/364 (44%), Gaps = 60/364 (16%)
Query: 618 KELEGVITKAIYKSSEEDKKEEEVKKTLEQ----HDNIVTHYKNMIREQDLQLEELRQQV 673
KEL + K + SE +K EE K+ + H N+ KN+ ++ +LE ++ +V
Sbjct: 419 KELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKE-KNLTKDLLNELEVVKSRV 477
Query: 674 STLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPE--- 730
L+C +L+ A + + K +L + + N + E +++G+
Sbjct: 478 KELECSESRLEKAELSLKDDLTKLKSFTVMLVDE--RKNMMEKIKQEERKVDGLNKNFKV 535
Query: 731 EIGRLREEIEEL-KRNQELLQ--SQLTEK--------DSMIENMKSSQTSGTNEQSSAIV 779
E G++ + E+L + +++LL+ S++ EK D +I +KS + + S +
Sbjct: 536 EQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDL 595
Query: 780 SARDSEQVAELKQELATLKSQLNSQ------------SVEITKLQTEKQEL------LQK 821
+ + + E+++E+ +S+ S+ ++EI +L+ Q+L L K
Sbjct: 596 LKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMK 655
Query: 822 TEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEI---KALSE-----ERTA 873
TE +E + TE + + + L Q+ +E+K++I KA+ + +
Sbjct: 656 TEDEYDQLEQKFRTE----------QDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAE 705
Query: 874 IKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQ---DQKILSLKNKLKDL 930
++ + + L+ E L+ +I + ++D L L D Q+ + +NK K++
Sbjct: 706 LRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNM 765
Query: 931 GHPV 934
G V
Sbjct: 766 GQEV 769
Score = 50.1 bits (118), Expect = 1e-05
Identities = 92/438 (21%), Positives = 186/438 (42%), Gaps = 54/438 (12%)
Query: 561 KEKLKQLIEKRIGKENFIEKLGFISKHELYSRA-------SQKPQPNFPSPEYMIFDHEF 613
+ K K+ +E + KE+ I+ L I + EL +R ++K +P Y + E
Sbjct: 66 ERKTKKSLE--LSKEDLIQLLS-IMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEK 122
Query: 614 TKLVKELEGVITKA------IYKS--SEEDKKEEEVKKT----LEQ-------HDNIVTH 654
V + ++ + +Y+ SE D+ EE+ K+T LEQ H V
Sbjct: 123 VLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYE 182
Query: 655 YKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQ----QVSQIQQHKDQYNLLKIQLGK 710
+N + + + + L+ + E+L+ + Q Q + +++ + N L+ +L K
Sbjct: 183 LENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVK 242
Query: 711 DNQHQGSYSEGAQMN----GIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENM--- 763
+ QM+ G+Q +++ L +++ E + + + S+ E + +
Sbjct: 243 LKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVD 302
Query: 764 ---KSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQ 820
K+S+ S +E+ +A ++ ++S +L+ +L L ++ LQ ++EL +
Sbjct: 303 FEHKASRFSQEHEEMNAKLANQESHN-RQLRLKLVGLTQRIEELEETNKNLQKAEEELQE 361
Query: 821 KTEAFAK----SVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKE 876
+ AK + + E E + + ++EG+ + + + + K L EE KE
Sbjct: 362 LRDKIAKGECGNSSLMAEVENL-RKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKE 420
Query: 877 QLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEE 936
L + +E +KLE + SK E L + L + L N+L+ + V+E
Sbjct: 421 -LRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKE 479
Query: 937 ----EDELESGDQEDEDD 950
E LE + +DD
Sbjct: 480 LECSESRLEKAELSLKDD 497
Score = 48.5 bits (114), Expect = 3e-05
Identities = 60/333 (18%), Positives = 147/333 (44%), Gaps = 28/333 (8%)
Query: 609 FDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEE 668
F+H+ ++ +E E + K + S + ++ ++ + + KN+ + ++ +L+E
Sbjct: 303 FEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEE-ELQE 361
Query: 669 LRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQ 728
LR +++ +C N L V ++ + + GKD + + S+ ++
Sbjct: 362 LRDKIAKGECGNSSLMAEVENLRKRVLEME----------GKDEEITKTESQCRELRKKL 411
Query: 729 PEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVA 788
EE +EL+ E LQ +++E + + E S++ T + ++
Sbjct: 412 QEE----EHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNL---EKEKNLTK 464
Query: 789 ELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEG 848
+L EL +KS++ + +E ++ + EK EL K + +++ T ++ + +E
Sbjct: 465 DLLNELEVVKSRV--KELECSESRLEKAELSLKDDL----TKLKSFTVMLVDERKNMME- 517
Query: 849 RLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDD 908
+ QE +++ K E+ + + + L K ++E ++ + +E+D+
Sbjct: 518 ---KIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDE 574
Query: 909 LLVLLADQDQKILSLKNKLKDLGHPVEEEDELE 941
L+ L +++K L + L ++ +E+E
Sbjct: 575 LIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVE 607
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 65.9 bits (159), Expect = 2e-10
Identities = 63/312 (20%), Positives = 138/312 (44%), Gaps = 44/312 (14%)
Query: 635 DKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQI 694
D KE +V ++ +N+ + +R+++ Q+ L+++V +L+ TA+T +
Sbjct: 567 DVKERKVNVLQKKIENL----QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL 622
Query: 695 QQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLT 754
+ + LK Q +D + + EEI ++++++LK LLQ L+
Sbjct: 623 AEKERTIERLKEQRDRDEREK-------------QEEIDNYKKDLKDLKEKVSLLQGDLS 669
Query: 755 EKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTE 814
EK++ + ++K E +S++ S+ + L TL+ L + E K++++
Sbjct: 670 EKEASLLDLK--------EHASSLASSG-----LKKDSRLKTLEIALEQKKEECLKMESQ 716
Query: 815 KQELLQKTEAFAKSVEVQGETE------TIIATKTTDVEGRLSALLQETKELKNEIKALS 868
++ + S E+ + T +++ + + LL+ KE++NE
Sbjct: 717 LKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKD 776
Query: 869 EERTAIKEQLDSSNSTIAIL----QTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLK 924
++ ++ Q+ N +A L Q EK K + ++++ +D+ L D Q++
Sbjct: 777 KKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDN----LNDSSQQLQDSL 832
Query: 925 NKLKDLGHPVEE 936
K D +EE
Sbjct: 833 RKKDDRIEELEE 844
Score = 60.1 bits (144), Expect = 1e-08
Identities = 67/329 (20%), Positives = 147/329 (44%), Gaps = 38/329 (11%)
Query: 610 DHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEEL 669
D KL++ L+ A K++EED + E H V H ++++ +++ + L
Sbjct: 306 DESIKKLLEMLQSKGLSA--KATEEDHERTRRLAEAEMH---VHHLESLLEQKEKENSML 360
Query: 670 RQQVSTL------KCQNEQLQTAVTQQVSQIQQHKDQYNLLK--IQLGKDNQHQGSYSEG 721
R+++ + + LQT + + S+I + L+ IQ+ K N G+ S
Sbjct: 361 REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSN---GALSTE 417
Query: 722 AQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSA 781
+ ++ E+ R + +K E L+ +L+ K++ E +K
Sbjct: 418 EREEEMKQMEVYRSHSKF--MKNKVEQLKEELSSKEAQWEELK----------------- 458
Query: 782 RDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIAT 841
++ A L+ E+ +K +L+ + E+ LQT+ + L + + +EV E+ T
Sbjct: 459 ---KKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQ 515
Query: 842 KTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITD 901
+ ++ + AL +E + + +++ + E+ + I L+ D E ++
Sbjct: 516 RAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNV 575
Query: 902 SKKEQDDLLVLLADQDQKILSLKNKLKDL 930
+K+ ++L L D+++++ SLK ++K L
Sbjct: 576 LQKKIENLQEQLRDKEKQMSSLKERVKSL 604
Score = 58.5 bits (140), Expect = 3e-08
Identities = 65/350 (18%), Positives = 147/350 (42%), Gaps = 11/350 (3%)
Query: 624 ITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQN-EQ 682
I K Y+ +E+ + ++ Q + + N + +QD V+ L +N ++
Sbjct: 210 IWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQR 269
Query: 683 LQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQ--MNGIQPEEIG-RLREEI 739
L +Q ++ + +++++ Q + E + + +Q + + + EE
Sbjct: 270 LHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEED 329
Query: 740 EELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKS 799
E R + + +S++E + + E +A DS + L+ + S
Sbjct: 330 HERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDS 389
Query: 800 QLNSQSVEITKLQTEKQEL-------LQKTEAFAKSVEVQGETETIIATKTTDVEGRLSA 852
+++S + L+ E Q L ++ E K +EV + K ++ LS+
Sbjct: 390 KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSS 449
Query: 853 LLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVL 912
+ +ELK + L E +K++L ++ + LQT+ + L + +DSK+ + L
Sbjct: 450 KEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES 509
Query: 913 LADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDHI 962
L ++Q+ L+ ++ L +EE++ + + + D +E+ G I
Sbjct: 510 LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 559
Score = 55.8 bits (133), Expect = 2e-07
Identities = 67/341 (19%), Positives = 148/341 (43%), Gaps = 45/341 (13%)
Query: 629 YKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIR--EQDLQLEELRQQVSTLKCQNEQLQTA 686
++++ + K + ++ +E D+ ++ + +R E+++Q+ + +ST + + E Q
Sbjct: 368 FENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQME 427
Query: 687 VTQQVSQIQQHKDQYNLLKIQLG-KDNQHQGSYSEGAQMN---GIQPEEIGRLREEIEEL 742
V + S+ ++K + LK +L K+ Q + + A + G +E+ R E+ L
Sbjct: 428 VYRSHSKFMKNKVEQ--LKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLAL 485
Query: 743 KRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSA-----------------RDSE 785
+ E L +Q ++ IE +K S T+ EQ +AI+ + ++
Sbjct: 486 QTKLETLTNQFSDSKQHIEVLKESLTA--KEQRAAILQTEVDALRLRLEEKETMLNKKTK 543
Query: 786 QVAELKQELAT-------LKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETI 838
Q+ ++ +E T LK L+ + ++ LQ + + L ++ K + E
Sbjct: 544 QIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKS 603
Query: 839 IATKTTDVEGRLSALLQETKELKNEIKALSEERTA-----------IKEQLDSSNSTIAI 887
+ TT+ + L+ L + E + I+ L E+R K+ L +++
Sbjct: 604 LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 663
Query: 888 LQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLK 928
LQ + + E + D K+ L +D ++ +L+ L+
Sbjct: 664 LQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALE 704
Score = 55.8 bits (133), Expect = 2e-07
Identities = 63/353 (17%), Positives = 159/353 (45%), Gaps = 45/353 (12%)
Query: 617 VKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVT---HYKNMIREQDLQ-LEELRQQ 672
V L ++ + + +++DKK E+++ ++ + V H + + +++ Q LEE R++
Sbjct: 758 VDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR 817
Query: 673 VSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEE- 731
L ++QLQ ++ ++ +I++ ++ +Q+ + + + E A+ N + E
Sbjct: 818 EDNLNDSSQQLQDSLRKKDDRIEELEEALR-ESVQITAEREMVLAQEESARTNAEKQVEE 876
Query: 732 ----IGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQV 787
+ ++++E+E +K Q L EK++ + N+++ + + E+V
Sbjct: 877 LLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAER-------------RKHLEEV 923
Query: 788 AELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVE 847
E+KQE ++ + +L + K++ ++ A + E + ++ +
Sbjct: 924 LEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKR------EKDRLVQQLKQQTQ 977
Query: 848 GRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLEL---EITDSKK 904
R+ + ++ + K+ +T K D + L + KL+L +T
Sbjct: 978 NRMKLMADNYED--DHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCH 1035
Query: 905 EQDDLLV--------LLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDED 949
++D L++ D DQ + +N+L+ + + +DELE G++++ +
Sbjct: 1036 DRDPLILRGLTPPASYNLDDDQ--AAWENELQKMTRG-QLQDELEKGERDNAE 1085
Score = 45.4 bits (106), Expect = 2e-04
Identities = 50/224 (22%), Positives = 96/224 (42%), Gaps = 34/224 (15%)
Query: 612 EFTKLVKELEGVITKAIYKSSEEDKKE----EEVKKTLEQHDNIVTHYKNMIREQDLQLE 667
E + VK+ + +K E KK EE ++ + ++ ++ +R++D ++E
Sbjct: 781 ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 840
Query: 668 ELRQQV----------STLKCQNEQLQTAVTQQVSQI----QQHKDQYNLLKIQLGKDNQ 713
EL + + + Q E +T +QV ++ ++ K + +K +L Q
Sbjct: 841 ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 900
Query: 714 HQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNE 773
+ + ++ E L EE+ E+K QE L + ++EKD+ I ++ S +
Sbjct: 901 SLAE--KETHLTNLRAERRKHL-EEVLEMK--QEALLAAISEKDANIALLELSSS----- 950
Query: 774 QSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQE 817
+ E+VA LK+E L QL Q+ KL + E
Sbjct: 951 ------KKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYE 988
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 65.9 bits (159), Expect = 2e-10
Identities = 63/312 (20%), Positives = 138/312 (44%), Gaps = 44/312 (14%)
Query: 635 DKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQI 694
D KE +V ++ +N+ + +R+++ Q+ L+++V +L+ TA+T +
Sbjct: 539 DVKERKVNVLQKKIENL----QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL 594
Query: 695 QQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLT 754
+ + LK Q +D + + EEI ++++++LK LLQ L+
Sbjct: 595 AEKERTIERLKEQRDRDEREK-------------QEEIDNYKKDLKDLKEKVSLLQGDLS 641
Query: 755 EKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTE 814
EK++ + ++K E +S++ S+ + L TL+ L + E K++++
Sbjct: 642 EKEASLLDLK--------EHASSLASSG-----LKKDSRLKTLEIALEQKKEECLKMESQ 688
Query: 815 KQELLQKTEAFAKSVEVQGETE------TIIATKTTDVEGRLSALLQETKELKNEIKALS 868
++ + S E+ + T +++ + + LL+ KE++NE
Sbjct: 689 LKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKD 748
Query: 869 EERTAIKEQLDSSNSTIAIL----QTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLK 924
++ ++ Q+ N +A L Q EK K + ++++ +D+ L D Q++
Sbjct: 749 KKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDN----LNDSSQQLQDSL 804
Query: 925 NKLKDLGHPVEE 936
K D +EE
Sbjct: 805 RKKDDRIEELEE 816
Score = 56.2 bits (134), Expect = 1e-07
Identities = 55/305 (18%), Positives = 136/305 (44%), Gaps = 6/305 (1%)
Query: 632 SEEDKKEEEV---KKTLEQHDNIVTHYKNMIREQDLQLEELRQQVST--LKCQNEQLQTA 686
+E +++ +E+ +KTLE+ + + K + +D +++L + + + L + +
Sbjct: 272 AEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHE 331
Query: 687 VTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQ 746
T+++++ + H L Q K+N N + L+ IE
Sbjct: 332 RTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKI 391
Query: 747 ELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAE-LKQELATLKSQLNSQS 805
++ L + + I+ +KS+ T E+ + ++ +K ++ +K +L+ +
Sbjct: 392 SSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKD 451
Query: 806 VEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIK 865
E+ LQT+ + L + + +EV E+ T + ++ + AL +E + +
Sbjct: 452 TELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLN 511
Query: 866 ALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKN 925
+++ + E+ + I L+ D E ++ +K+ ++L L D+++++ SLK
Sbjct: 512 KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 571
Query: 926 KLKDL 930
++K L
Sbjct: 572 RVKSL 576
Score = 55.8 bits (133), Expect = 2e-07
Identities = 63/353 (17%), Positives = 159/353 (45%), Gaps = 45/353 (12%)
Query: 617 VKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVT---HYKNMIREQDLQ-LEELRQQ 672
V L ++ + + +++DKK E+++ ++ + V H + + +++ Q LEE R++
Sbjct: 730 VDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR 789
Query: 673 VSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEE- 731
L ++QLQ ++ ++ +I++ ++ +Q+ + + + E A+ N + E
Sbjct: 790 EDNLNDSSQQLQDSLRKKDDRIEELEEALR-ESVQITAEREMVLAQEESARTNAEKQVEE 848
Query: 732 ----IGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQV 787
+ ++++E+E +K Q L EK++ + N+++ + + E+V
Sbjct: 849 LLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAER-------------RKHLEEV 895
Query: 788 AELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVE 847
E+KQE ++ + +L + K++ ++ A + E + ++ +
Sbjct: 896 LEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKR------EKDRLVQQLKQQTQ 949
Query: 848 GRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLEL---EITDSKK 904
R+ + ++ + K+ +T K D + L + KL+L +T
Sbjct: 950 NRMKLMADNYED--DHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCH 1007
Query: 905 EQDDLLV--------LLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDED 949
++D L++ D DQ + +N+L+ + + +DELE G++++ +
Sbjct: 1008 DRDPLILRGLTPPASYNLDDDQ--AAWENELQKMTRG-QLQDELEKGERDNAE 1057
Score = 55.5 bits (132), Expect = 2e-07
Identities = 77/382 (20%), Positives = 161/382 (42%), Gaps = 54/382 (14%)
Query: 626 KAIYKSSEEDKKEEEVK--KTLEQHDNIVTHYK-NMIREQDLQLEEL------RQQVSTL 676
K + + ++ +K+ EVK K ++I T + + +E+ L+ +E ++Q +
Sbjct: 159 KEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVV 218
Query: 677 KCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLR 736
+ +N+ +Q + +++ +D L + Q S + + + E RL
Sbjct: 219 QEENQHMQMTIQALQDELRIQRDLNQLFQ-------QDSSSRTGEPCVAELTEENFQRLH 271
Query: 737 EEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQS-------------SAIVSARD 783
E E + LL+ L E + IE K QT ++S SA + D
Sbjct: 272 AEHERQAKELFLLRKTLEEMELRIETQK--QTLNARDESIKKLLEMLQSKGLSAKATEED 329
Query: 784 SEQ---VAELKQELATLKSQLNSQSVEITKLQTEKQELLQ------KTEAFAKSVEVQGE 834
E+ +AE + + L+S L + E + L+ E + KT+A +E++
Sbjct: 330 HERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDS 389
Query: 835 TETIIATKTTDVEGRLSALLQE----TKELKNEIKALSEERT----------AIKEQLDS 880
+ + D+E + L T+E + E+K + R+ +K++L
Sbjct: 390 KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSR 449
Query: 881 SNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDEL 940
++ + LQT+ + L + +DSK+ + L L ++Q+ L+ ++ L +EE++ +
Sbjct: 450 KDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETM 509
Query: 941 ESGDQEDEDDESEDPGKDLDHI 962
+ + D +E+ G I
Sbjct: 510 LNKKTKQIQDMAEEKGTQAGEI 531
Score = 51.6 bits (122), Expect = 3e-06
Identities = 73/378 (19%), Positives = 154/378 (40%), Gaps = 66/378 (17%)
Query: 610 DHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEEL 669
D KL++ L+ A K++EED + E H V H ++++ +++ + L
Sbjct: 306 DESIKKLLEMLQSKGLSA--KATEEDHERTRRLAEAEMH---VHHLESLLEQKEKENSML 360
Query: 670 RQQVSTL------KCQNEQLQTAVTQQVSQIQQHKDQYNLLK--IQLGKDNQHQGSYSEG 721
R+++ + + LQT + + S+I + L+ IQ+ K N +
Sbjct: 361 REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420
Query: 722 AQMNGIQ---------PEEIGRLREEIEE-------LKRNQELLQSQLTEKDSMIENMKS 765
+M ++ +IG++++E+ L+ E L +Q ++ IE +K
Sbjct: 421 EEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE 480
Query: 766 SQTSGTNEQSSAIVSA-----------------RDSEQVAELKQELAT-------LKSQL 801
S T+ EQ +AI+ + ++Q+ ++ +E T LK L
Sbjct: 481 SLTA--KEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDML 538
Query: 802 NSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELK 861
+ + ++ LQ + + L ++ K + E + TT+ + L+ L + E +
Sbjct: 539 DVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKE 598
Query: 862 NEIKALSEERTA-----------IKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLL 910
I+ L E+R K+ L +++LQ + + E + D K+ L
Sbjct: 599 RTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLA 658
Query: 911 VLLADQDQKILSLKNKLK 928
+D ++ +L+ L+
Sbjct: 659 SSGLKKDSRLKTLEIALE 676
Score = 45.4 bits (106), Expect = 2e-04
Identities = 50/224 (22%), Positives = 96/224 (42%), Gaps = 34/224 (15%)
Query: 612 EFTKLVKELEGVITKAIYKSSEEDKKE----EEVKKTLEQHDNIVTHYKNMIREQDLQLE 667
E + VK+ + +K E KK EE ++ + ++ ++ +R++D ++E
Sbjct: 753 ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 812
Query: 668 ELRQQV----------STLKCQNEQLQTAVTQQVSQI----QQHKDQYNLLKIQLGKDNQ 713
EL + + + Q E +T +QV ++ ++ K + +K +L Q
Sbjct: 813 ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 872
Query: 714 HQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNE 773
+ + ++ E L EE+ E+K QE L + ++EKD+ I ++ S +
Sbjct: 873 SLAE--KETHLTNLRAERRKHL-EEVLEMK--QEALLAAISEKDANIALLELSSS----- 922
Query: 774 QSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQE 817
+ E+VA LK+E L QL Q+ KL + E
Sbjct: 923 ------KKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYE 960
>gi|19924131 RAD50 homolog isoform 2 [Homo sapiens]
Length = 1173
Score = 65.9 bits (159), Expect = 2e-10
Identities = 82/429 (19%), Positives = 190/429 (44%), Gaps = 48/429 (11%)
Query: 550 YF-NDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMI 608
YF N LE ++ K K++ + R ++L ++K AS + N + E
Sbjct: 430 YFPNKKQLEDWLHSKSKEINQTR-------DRLAKLNKE----LASSEQNKNHINNELKR 478
Query: 609 FDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQH------DNIVTHYKNMIREQ 662
+ + + +L V ++S + D+ +EE++K+ +Q + + + + ++
Sbjct: 479 KEEQLSSYEDKLFDVCGSQDFES-DLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDE 537
Query: 663 DLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQ----GSY 718
+ + Q+V + + LQ ++ S+++ D+ + +L K + + G
Sbjct: 538 NQSCCPVCQRVFQTEAE---LQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLV 594
Query: 719 SEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAI 778
+ ++ +EI LR +++ + R+ + L++ + E+++++ + + S +
Sbjct: 595 PMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVT 654
Query: 779 VSARDSEQVAELKQELATLKSQLNSQSVEITKLQT--EKQELLQKTEAFAKSVE-----V 831
+ R ++ ++++++A ++L ++ T Q EKQE K + + +E +
Sbjct: 655 IMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLI 714
Query: 832 QGETETIIATKTTDVE------------GRLSALLQETKELKNEIKALSEERTAIKEQLD 879
Q + E I K+T E R L ++T EL E+++L E KEQ+
Sbjct: 715 QDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVS 774
Query: 880 SSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDE 939
+T+ Q EK++L + S K D L D +K+ ++ +KD+ + +++ +
Sbjct: 775 PLETTLEKFQQEKEELINKKNTSNKIAQD---KLNDIKEKVKNIHGYMKDIENYIQDGKD 831
Query: 940 LESGDQEDE 948
+E E
Sbjct: 832 DYKKQKETE 840
Score = 55.5 bits (132), Expect = 2e-07
Identities = 77/399 (19%), Positives = 167/399 (41%), Gaps = 57/399 (14%)
Query: 610 DHEFTKLVK---ELEGVITKAIYKSSEEDKKEEEVKK----TLEQHDNIVTHYKNMIREQ 662
+H +K++K E++ + ++ + + EE+++K T EQ +++ +++ +RE+
Sbjct: 120 EHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREK 179
Query: 663 DLQLEE--------------LRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQL 708
+ +L + L Q+ S L + +LQ + I+ L QL
Sbjct: 180 ERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQL 239
Query: 709 GKDNQHQGSYSEG---------------------------AQMNGIQPEEIGRLREEIEE 741
D +G +SE A+ ++ ++I +R++
Sbjct: 240 ELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTG 299
Query: 742 LKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQV-AELKQELATLKSQ 800
L R EL L++K + ++N+K E SS + D E + AE + A S
Sbjct: 300 LGRIIELKSEILSKKQNELKNVKYELQQ--LEGSSDRILELDQELIKAERELSKAEKNSN 357
Query: 801 LNSQSVEITKLQTEKQEL---LQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQET 857
+ + +E+ LQ EK +L L+K + + + T T + T D + + +
Sbjct: 358 VETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIK 417
Query: 858 KELKNEIKAL---SEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLA 914
+E+ +L + +++ L S + I + KL E+ S++ ++ + L
Sbjct: 418 SRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELK 477
Query: 915 DQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESE 953
+++++ S ++KL D+ + E +L+ +E E +
Sbjct: 478 RKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQ 516
>gi|19924129 RAD50 homolog isoform 1 [Homo sapiens]
Length = 1312
Score = 65.9 bits (159), Expect = 2e-10
Identities = 82/429 (19%), Positives = 190/429 (44%), Gaps = 48/429 (11%)
Query: 550 YF-NDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSPEYMI 608
YF N LE ++ K K++ + R ++L ++K AS + N + E
Sbjct: 569 YFPNKKQLEDWLHSKSKEINQTR-------DRLAKLNKE----LASSEQNKNHINNELKR 617
Query: 609 FDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQH------DNIVTHYKNMIREQ 662
+ + + +L V ++S + D+ +EE++K+ +Q + + + + ++
Sbjct: 618 KEEQLSSYEDKLFDVCGSQDFES-DLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDE 676
Query: 663 DLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQ----GSY 718
+ + Q+V + + LQ ++ S+++ D+ + +L K + + G
Sbjct: 677 NQSCCPVCQRVFQTEAE---LQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLV 733
Query: 719 SEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAI 778
+ ++ +EI LR +++ + R+ + L++ + E+++++ + + S +
Sbjct: 734 PMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTDVT 793
Query: 779 VSARDSEQVAELKQELATLKSQLNSQSVEITKLQT--EKQELLQKTEAFAKSVE-----V 831
+ R ++ ++++++A ++L ++ T Q EKQE K + + +E +
Sbjct: 794 IMERFQMELKDVERKIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLI 853
Query: 832 QGETETIIATKTTDVE------------GRLSALLQETKELKNEIKALSEERTAIKEQLD 879
Q + E I K+T E R L ++T EL E+++L E KEQ+
Sbjct: 854 QDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVS 913
Query: 880 SSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDE 939
+T+ Q EK++L + S K D L D +K+ ++ +KD+ + +++ +
Sbjct: 914 PLETTLEKFQQEKEELINKKNTSNKIAQD---KLNDIKEKVKNIHGYMKDIENYIQDGKD 970
Query: 940 LESGDQEDE 948
+E E
Sbjct: 971 DYKKQKETE 979
Score = 55.5 bits (132), Expect = 2e-07
Identities = 77/399 (19%), Positives = 167/399 (41%), Gaps = 57/399 (14%)
Query: 610 DHEFTKLVK---ELEGVITKAIYKSSEEDKKEEEVKK----TLEQHDNIVTHYKNMIREQ 662
+H +K++K E++ + ++ + + EE+++K T EQ +++ +++ +RE+
Sbjct: 259 EHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREK 318
Query: 663 DLQLEE--------------LRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQL 708
+ +L + L Q+ S L + +LQ + I+ L QL
Sbjct: 319 ERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQL 378
Query: 709 GKDNQHQGSYSEG---------------------------AQMNGIQPEEIGRLREEIEE 741
D +G +SE A+ ++ ++I +R++
Sbjct: 379 ELDGFERGPFSERQIKNFHKLVRERQEGEAKTANQLMNDFAEKETLKQKQIDEIRDKKTG 438
Query: 742 LKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQV-AELKQELATLKSQ 800
L R EL L++K + ++N+K E SS + D E + AE + A S
Sbjct: 439 LGRIIELKSEILSKKQNELKNVKYELQQ--LEGSSDRILELDQELIKAERELSKAEKNSN 496
Query: 801 LNSQSVEITKLQTEKQEL---LQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQET 857
+ + +E+ LQ EK +L L+K + + + T T + T D + + +
Sbjct: 497 VETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIK 556
Query: 858 KELKNEIKAL---SEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLA 914
+E+ +L + +++ L S + I + KL E+ S++ ++ + L
Sbjct: 557 SRHSDELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASSEQNKNHINNELK 616
Query: 915 DQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESE 953
+++++ S ++KL D+ + E +L+ +E E +
Sbjct: 617 RKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQ 655
Score = 31.6 bits (70), Expect = 3.7
Identities = 45/226 (19%), Positives = 88/226 (38%), Gaps = 39/226 (17%)
Query: 738 EIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATL 797
E+ ++R+ Q + +E + + G S+ + D E ++ L A L
Sbjct: 92 ELIAVQRSMVCTQKSKKTEFKTLEGVITRTKHGEKVSLSSKCAEIDREMISSLGVSKAVL 151
Query: 798 KSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQET 857
+ + + +E + L QK + + ET+ + T Q+
Sbjct: 152 NNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQG--------QKV 203
Query: 858 KELKNEIKALS---EERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLA 914
KE + E+K L E+ I++Q+ S E ++T SK+ ++
Sbjct: 204 KEYQMELKYLKQYKEKACEIRDQITSK--------------EAQLTSSKE-------IVK 242
Query: 915 DQDQKILSLKNKLKDLGHPV-------EEEDELESGDQEDEDDESE 953
+ ++ LKN+LK++ H + E L+S ++ E D SE
Sbjct: 243 SYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSE 288
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 65.9 bits (159), Expect = 2e-10
Identities = 89/355 (25%), Positives = 166/355 (46%), Gaps = 53/355 (14%)
Query: 612 EFTKLVKELEGVITKAIYKSSEEDK------KEEEVKKTLEQHDNIVTHYKNMIREQDLQ 665
E TKL+ +L K + + E+DK + ++ +TLE + + ++ I++ Q
Sbjct: 340 EKTKLITQLRDA--KNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQ 397
Query: 666 LEELRQQ-VSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQM 724
EELR+Q + + E+L+ A +S Q+ ++ LK ++ + + SE ++
Sbjct: 398 GEELREQKEKSERAAFEELEKA----LSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERI 453
Query: 725 NGIQPEEIGRLREEI---------EELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQS 775
+ +E+ R+++E+ E++ + Q+L + +L K+ + ++ EQ
Sbjct: 454 S--LQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQM 511
Query: 776 SAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGET 835
+ SE + ++ QE K Q +S+ + +L+ +K+ +L TE+ K ++Q E
Sbjct: 512 KVALEKSQSEYL-KISQE----KEQ--QESLALEELELQKKAIL--TESENKLRDLQQEA 562
Query: 836 ETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKL 895
ET T+ ++E L LQE KN+ K L+ A K + N I ++ EK K
Sbjct: 563 ET-YRTRILELESSLEKSLQEN---KNQSKDLAVHLEAEK---NKHNKEITVM-VEKHKT 614
Query: 896 ELEITDSKKEQDDLLVLLADQDQKILSLK----NKLKDLGHPVEEEDELESGDQE 946
ELE S K Q D L +K+ LK +++ L E+E E D+E
Sbjct: 615 ELE---SLKHQQDAL-----WTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKE 661
Score = 65.5 bits (158), Expect = 2e-10
Identities = 83/372 (22%), Positives = 165/372 (44%), Gaps = 41/372 (11%)
Query: 614 TKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIR--EQDLQLEELRQ 671
T+L KEL I E +K+ E+ +Q ++ +N I E++ + LR+
Sbjct: 1342 TQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRK 1401
Query: 672 QVSTLKCQ--------NEQLQTAVTQQVSQIQQHKDQYNLL----KIQLGKDNQHQGSYS 719
Q KC+ + ++ T +++S ++Q D N K + QHQ +
Sbjct: 1402 QYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVK 1461
Query: 720 E-------GAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTN 772
E ++ + E+I L+EE+++ + + L+ ++ + S +E +S+ +
Sbjct: 1462 ELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELK 1521
Query: 773 EQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQ 832
Q++ I+ D + + E+ +L L + + + E +EL+QK + F + E +
Sbjct: 1522 SQTARIMELED--HITQKTIEIESLNEVLKNYN---QQKDIEHKELVQKLQHFQELGEEK 1576
Query: 833 G----ETETIIATKTTDVEGRLSALLQETKELKN---EIKALSEERTAIKEQLDSSNSTI 885
E E I T V + L + KEL++ +K+ EE A++++L+S ++
Sbjct: 1577 DNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESA-- 1634
Query: 886 AILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDE----LE 941
A L K K E +I KK+ L + ++Q ++ L +L ++E + LE
Sbjct: 1635 AKLAELKRKAEQKIAAIKKQL--LSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILE 1692
Query: 942 SGDQEDEDDESE 953
+ E +SE
Sbjct: 1693 EKLKSVESSQSE 1704
Score = 61.6 bits (148), Expect = 3e-09
Identities = 87/447 (19%), Positives = 177/447 (39%), Gaps = 83/447 (18%)
Query: 561 KEKLKQLIEKRIGKENFIEKLG------FISKHELYSRASQKPQPNFPSPEYMIFDHEFT 614
K++++ L +K KE+ I L F ++ + + QK + + + + D E
Sbjct: 921 KKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQE-A 979
Query: 615 KLVKELEGVITKAIYKSSE-----------------------EDKKEEEVKKTLEQH--- 648
KL KELE + K + E ++E+++ E H
Sbjct: 980 KLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRE 1039
Query: 649 -DNIVTHYKNMIREQ--------DLQLEELRQQVSTLK-------CQNEQLQTAVTQQVS 692
+++++ ++ + +Q ++QL+E Q+V+ LK C+ E++ +T
Sbjct: 1040 LNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKE 1099
Query: 693 QIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQ 752
+ + N L+ QL + + H S AQ + +L ++ + + LQ Q
Sbjct: 1100 EGVKQDTTLNELQEQLKQKSAHVNSL---AQDETKLKAHLEKLEVDLNKSLKENTFLQEQ 1156
Query: 753 LTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQ 812
L E + E K + T++ + E+ LK L +S+E KL
Sbjct: 1157 LVELKMLAEEDKRKVSELTSKLKTT------DEEFQSLKSSHEKSNKSLEDKSLEFKKL- 1209
Query: 813 TEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERT 872
+EL + + K +TE ++ KT ++ ++ +T + + I T
Sbjct: 1210 --SEELAIQLDICCK------KTEALLEAKTNEL---INISSSKTNAILSRISHCQHRTT 1258
Query: 873 AIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGH 932
+KE L T++ +LE ++ +EQ+ L + ++ +N++K +
Sbjct: 1259 KVKEALLIKTCTVS-------ELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKA 1311
Query: 933 PVE------EEDELESGDQEDEDDESE 953
+E E + E G+Q+ E E
Sbjct: 1312 DIESLVTEKEALQKEGGNQQQAASEKE 1338
Score = 57.4 bits (137), Expect = 6e-08
Identities = 69/351 (19%), Positives = 150/351 (42%), Gaps = 38/351 (10%)
Query: 617 VKELEGVITKAIYKSSEEDKK-EEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVST 675
+ ELE + K++ ++ + K ++ +H+ +T M+ + +LE L+ Q
Sbjct: 569 ILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV---MVEKHKTELESLKHQQDA 625
Query: 676 LKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQ-----HQGSYSEGA-QMNGIQP 729
L E+LQ Q +++++ +++ K L KD + H +E + ++
Sbjct: 626 L--WTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQ 683
Query: 730 EEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDS---EQ 786
E+ L E+ E+ + + L+ +L+ + MK + +EQ + DS E
Sbjct: 684 TELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEH 743
Query: 787 VAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDV 846
+++ LK Q+N ++ L E+ + L++ +A +++E +
Sbjct: 744 EVSIQRTEKALKDQIN----QLELLLKERDKHLKEHQAHVENLEADIKRS---------- 789
Query: 847 EGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQ 906
EG L + ++ A E+ A +EQL + L+TE+ L ++ + + ++
Sbjct: 790 EGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQK 849
Query: 907 DDLLVLLADQDQKILSLKNKLKDLGHPVEE---------EDELESGDQEDE 948
D+ L ++ L +L+ +E+ E +LE G++E E
Sbjct: 850 KDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQE 900
Score = 57.4 bits (137), Expect = 6e-08
Identities = 76/362 (20%), Positives = 158/362 (43%), Gaps = 41/362 (11%)
Query: 632 SEEDKKE-----EEVKKTLEQHDNIVT-HYKNMIREQDLQLE------ELRQQVSTLKCQ 679
+EEDK++ ++K T E+ ++ + H K+ +D LE EL Q+ +
Sbjct: 1164 AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKK 1223
Query: 680 NEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEI 739
E L A T ++ I K L +I QH+ + + A + I+ + L ++
Sbjct: 1224 TEALLEAKTNELINISSSKTNAILSRIS---HCQHRTTKVKEALL--IKTCTVSELEAQL 1278
Query: 740 EELKRNQELLQ-------SQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQ 792
+L Q L QL EK++ I++MK+ S E+ + + +Q A K+
Sbjct: 1279 RQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKE 1338
Query: 793 ELAT-LKSQLNSQSVEITKLQTEKQELLQKTEAFAK-----SVEVQ-----GETETIIAT 841
T LK +L+ +T ++ E +E + + +K +V++Q E E I++
Sbjct: 1339 SCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISS 1398
Query: 842 KTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITD 901
+ LL + ++L ++ LS+E+ + EQ+D ++ + K K + T
Sbjct: 1399 LRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFS---EWKKKAQSRFTQ 1455
Query: 902 SKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEED---ELESGDQEDEDDESEDPGKD 958
+ +L + L + ++ ++ L +++++ + G+ ED+ + E +
Sbjct: 1456 HQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESN 1515
Query: 959 LD 960
L+
Sbjct: 1516 LE 1517
Score = 52.8 bits (125), Expect = 2e-06
Identities = 69/348 (19%), Positives = 142/348 (40%), Gaps = 47/348 (13%)
Query: 614 TKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQV 673
T V ELE + ++ E + TL TH + E++ Q++ ++ +
Sbjct: 1268 TCTVSELEAQL-----------RQLTEEQNTLNISFQQATH---QLEEKENQIKSMKADI 1313
Query: 674 STLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIG 733
+L + E LQ Q + + LK +L ++ +N +
Sbjct: 1314 ESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSEN------------INAVT----- 1356
Query: 734 RLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQE 793
++EE++E K L QLT+ + ++N S +E+ +AI S R + +E
Sbjct: 1357 LMKEELKEKKVEISSLSKQLTDLNVQLQNSIS-----LSEKEAAISSLR-----KQYDEE 1406
Query: 794 LATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSAL 853
L Q+ S ++ L EK L++ + ++ E + ++ T + + L
Sbjct: 1407 KCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKF---SEWKKKAQSRFTQHQNTVKEL 1463
Query: 854 LQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLL 913
+ + E E+ +KE+LD N L K ++E + + +K++ +L L
Sbjct: 1464 QIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCL---KGEMEDDKSKMEKKESNLETEL 1520
Query: 914 ADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLDH 961
Q +I+ L++ + +E +E+ + +D E ++ + L H
Sbjct: 1521 KSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQH 1568
Score = 52.0 bits (123), Expect = 3e-06
Identities = 72/338 (21%), Positives = 142/338 (42%), Gaps = 44/338 (13%)
Query: 618 KELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLK 677
K+L+G++ S +DK + + E+ K++ E D LEE Q +S L+
Sbjct: 172 KKLQGIL------SQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQ 225
Query: 678 CQNEQLQTAV------TQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQ--- 728
Q L+ + + + Q + Q + + ++ + +G + ++
Sbjct: 226 TQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQ 285
Query: 729 -------------PEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQS 775
E I +E+ L +E LQ QL E+ +E +K + E++
Sbjct: 286 QRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMA---EKT 342
Query: 776 SAIVSARDSEQVAE-LKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGE 834
I RD++ + E L+Q+ + ++ Q E ++ K+E + + + K + QGE
Sbjct: 343 KLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEM---KEEEIAQLRSRIKQMTTQGE 399
Query: 835 -----TETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQ 889
E ++E LS Q+T+E + ++KA +E+ IK +S LQ
Sbjct: 400 ELREQKEKSERAAFEELEKALST-AQKTEEARRKLKAEMDEQ--IKTIEKTSEEERISLQ 456
Query: 890 TEKDKLELEITD-SKKEQDDLLVLLADQDQKILSLKNK 926
E +++ E+ D KK ++ + L +K L+ K +
Sbjct: 457 QELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ 494
Score = 50.8 bits (120), Expect = 6e-06
Identities = 68/303 (22%), Positives = 137/303 (45%), Gaps = 52/303 (17%)
Query: 627 AIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTA 686
A Y EE + V+KT E+ +++ +N+ + E+L Q+V ++ +
Sbjct: 1716 AAYTEQEEADSQGCVQKTYEEKISVLQ--RNLTEK-----EKLLQRVG------QEKEET 1762
Query: 687 VTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQ 746
V+ Q++++ L+K++ + QH+ IG L+EE+EE +
Sbjct: 1763 VSSHFEMRCQYQER--LIKLEHAEAKQHEDQ------------SMIGHLQEELEEKNKKY 1808
Query: 747 ELLQSQLTEKDSMIENMKSSQ-----------TSGTNEQSSAIVSARDSEQVAELKQELA 795
L+ +Q EK+ N+++ Q T E + I+ + E + L ++
Sbjct: 1809 SLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKE 1868
Query: 796 TLKSQLNSQSVEITKLQTEKQ--------ELLQK-TEAFAKSVEVQGETETIIATKTTDV 846
+ ++ + + KLQ +Q ELL++ TE +KS VQ + + + + D+
Sbjct: 1869 VHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDL 1928
Query: 847 EGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQ 906
E +L+ +E ++L EI L ++ ++++ + IL+ E D+ E K+EQ
Sbjct: 1929 EFKLAGAEREKQKLGKEIVRLQKDLRMLRKE---HQQELEILKKEYDQEREE--KIKQEQ 1983
Query: 907 DDL 909
+DL
Sbjct: 1984 EDL 1986
Score = 47.4 bits (111), Expect = 7e-05
Identities = 72/298 (24%), Positives = 143/298 (47%), Gaps = 34/298 (11%)
Query: 639 EEVKKTLEQHDNIVTHYKNMIREQDL----QLEELRQQVSTLKCQNEQLQTAV------- 687
++V+KTL++ + + I+E D Q E R ++ L + E+LQ
Sbjct: 1836 DDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNK 1895
Query: 688 -TQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPE------EIGRLREEIE 740
T+ + + + K + +L++ +L + + Q + E ++ G + E EI RL++++
Sbjct: 1896 PTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLE-FKLAGAEREKQKLGKEIVRLQKDLR 1954
Query: 741 EL-KRNQELLQSQLTEKDS-MIENMKSSQTSGTNEQSSAI--VSARDSEQVAELKQELA- 795
L K +Q+ L+ E D E +K Q + +S + + + Q+A+ +QEL
Sbjct: 1955 MLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEM 2014
Query: 796 TLKSQLN-SQSVEITKLQTEKQELLQKTEAFAKSVEVQGET----ETIIATKTTDVEGRL 850
T+K +N +Q VE L++ ++E Q + A+ + T E I+ + ++ ++
Sbjct: 2015 TIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKV 2074
Query: 851 SALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSK-KEQD 907
L + +EL+ + + E+ +E + N TI LQT+ + I+DSK KEQ+
Sbjct: 2075 RDLQTQLEELQKKYQQKLEQ----EENPGNDNVTIMELQTQLAQKTTLISDSKLKEQE 2128
Score = 33.9 bits (76), Expect = 0.75
Identities = 26/109 (23%), Positives = 52/109 (47%), Gaps = 10/109 (9%)
Query: 609 FDHEFTKLVKELEGVITKAIYKSSE---------EDKKEEEVKKTLEQHDNIVTHYKNMI 659
F+ + + +ELE I + I K+ E +++ + +KK E+ D++ K
Sbjct: 2001 FNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYE 2060
Query: 660 REQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQ-HKDQYNLLKIQ 707
D + EE+ +V L+ Q E+LQ Q++ Q + D ++++Q
Sbjct: 2061 EILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQ 2109
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 65.5 bits (158), Expect = 2e-10
Identities = 74/354 (20%), Positives = 149/354 (42%), Gaps = 61/354 (17%)
Query: 639 EEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQ-------- 690
E V K+ + I ++ + E + EE+++ +S L Q +LQT +
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKE 1296
Query: 691 --VSQIQQHKDQYNL----LKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKR 744
VSQ+ + K + LK QL ++N+ + + + Q + + LRE+ EE +
Sbjct: 1297 SIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSR---HDCDLLREQYEEEQE 1353
Query: 745 NQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQ 804
+ LQ L++ +S + ++ + +++ + A+ +L Q L + Q+ +
Sbjct: 1354 GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK-----KLAQRLQDSEEQVEAV 1408
Query: 805 SVEITKLQTEKQELLQKTEAFAKSVE-----------VQGETETIIA---TKTTDVEGRL 850
+ + L+ KQ L + E VE Q + ++A TK + + L
Sbjct: 1409 NAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAEL 1468
Query: 851 SALLQETKELKNEI---------------------KALSEERTAIKEQLDSSNSTIAILQ 889
A L+E++ L E+ K L +E + EQ+ + TI L+
Sbjct: 1469 EASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELE 1528
Query: 890 TEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKL----KDLGHPVEEEDE 939
+ ++ELE D + ++ L ++ KIL ++ +L ++ + E+DE
Sbjct: 1529 KSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDE 1582
Score = 60.8 bits (146), Expect = 6e-09
Identities = 44/157 (28%), Positives = 86/157 (54%), Gaps = 17/157 (10%)
Query: 788 AELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKS-----VEVQGETETIIATK 842
AE ++E+AT+K + E+ K + +++EL +K + ++VQ E+E ++
Sbjct: 844 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLL--- 900
Query: 843 TTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDS 902
D E R L++ +L+ +IK ++E R +E++++ L +K KLE E ++
Sbjct: 901 --DAEERCDQLIKAKFQLEAKIKEVTE-RAEDEEEINAE------LTAKKRKLEDECSEL 951
Query: 903 KKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDE 939
KK+ DDL + LA +++ + +NK+K+L + DE
Sbjct: 952 KKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDE 988
Score = 60.8 bits (146), Expect = 6e-09
Identities = 60/319 (18%), Positives = 147/319 (46%), Gaps = 23/319 (7%)
Query: 612 EFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQ 671
E ++ ++E E ++++ ++ EE+K+ LE+ + + ++ + LR+
Sbjct: 1287 ELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLRE 1346
Query: 672 QVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEE 731
Q + +LQ A+++ S++ Q + +Y IQ + + + + + AQ E+
Sbjct: 1347 QYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQ--RTEELEEAKKKLAQRLQDSEEQ 1404
Query: 732 IGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQ----- 786
+ + + L++ ++ LQ ++ +D M++ E+++++ +A D +Q
Sbjct: 1405 VEAVNAKCASLEKTKQRLQGEV--EDLMVD----------VERANSLAAALDKKQRNFDK 1452
Query: 787 -VAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTD 845
+AE K + +++L + E L TE +L E +E + + D
Sbjct: 1453 VLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIAD 1512
Query: 846 VEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKE 905
+ +++ + EL+ K + E+ I+ L+ + + + + + +++LE+T K E
Sbjct: 1513 LTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSE 1572
Query: 906 QDDLLVLLADQDQKILSLK 924
D +A++D++I LK
Sbjct: 1573 IDR---KIAEKDEEIEQLK 1588
Score = 59.7 bits (143), Expect = 1e-08
Identities = 83/413 (20%), Positives = 171/413 (41%), Gaps = 35/413 (8%)
Query: 545 LGISIYFNDNSLESYMKEKLKQLIEKRIGKENFIEKLGFISKHELYSRASQKPQPNFPSP 604
L + + N LE +K + +++ K+ E+L K Y + K +
Sbjct: 1045 LRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLK--KKDFEYCQLQSKVE------ 1096
Query: 605 EYMIFDHEFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDL 664
+ +F K +KEL+ I E +++ E + T + + + Y + E
Sbjct: 1097 DEQTLGLQFQKKIKELQARI-------EELEEEIEAERATRAKTEKQRSDYARELEELSE 1149
Query: 665 QLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSE-GAQ 723
+LEE ST N++ + + +++ Q+ + L K +H S +E G Q
Sbjct: 1150 RLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRK--KHADSVAELGEQ 1207
Query: 724 MNGIQ------PEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKS--SQTSGTNEQS 775
++ +Q +E + EI++L + E + + + ++ S+ G NE+
Sbjct: 1208 IDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEI 1267
Query: 776 SAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGET 835
+S +++ + L+ E L QL + +++L KQ Q+TE + +E + +
Sbjct: 1268 QRSLSELTTQK-SRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKA 1326
Query: 836 ETIIATKTTDVEGRLSAL---LQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTE- 891
+ +A L +E +E K E++ + + Q + T AI +TE
Sbjct: 1327 KNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEE 1386
Query: 892 ----KDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDEL 940
K KL + DS+++ + + A ++ L+ +++DL VE + L
Sbjct: 1387 LEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSL 1439
Score = 58.5 bits (140), Expect = 3e-08
Identities = 78/362 (21%), Positives = 149/362 (41%), Gaps = 51/362 (14%)
Query: 619 ELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNM----------IREQDLQLEE 668
ELE + ++ S+E K + ++ L+Q + + KN+ I E + E
Sbjct: 1467 ELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHE 1526
Query: 669 LRQQVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQ 728
L + ++ + +Q A+ + + ++ ++ +L+IQL E Q+
Sbjct: 1527 LEKSRKQIELEKADIQLALEEAEAALEH--EEAKILRIQL-----------ELTQVKSEI 1573
Query: 729 PEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVA 788
+I EEIE+LKRN + +E M+S+ + ++ AI R +++
Sbjct: 1574 DRKIAEKDEEIEQLKRNYQ----------RTVETMQSALDAEVRSRNEAI---RLKKKME 1620
Query: 789 ELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEG 848
E+ S N Q+ E K Q L+ T+ ++G+ + + + VE
Sbjct: 1621 GDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDA-LRGQED--LKEQLAIVER 1677
Query: 849 RLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTE-------KDKLELEITD 901
R + L E +EL+ ++ R +++L SN + +L T+ K KLE ++
Sbjct: 1678 RANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQ 1737
Query: 902 SKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEE--EDELESGDQEDEDDESEDPGKDL 959
+ E +D + ++K K + D EE +++ S E E KDL
Sbjct: 1738 LQSEVEDASRDARNAEEK---AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1794
Query: 960 DH 961
H
Sbjct: 1795 QH 1796
Score = 55.8 bits (133), Expect = 2e-07
Identities = 71/349 (20%), Positives = 149/349 (42%), Gaps = 51/349 (14%)
Query: 626 KAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQT 685
K + KS+E +K+ +K+ ++ K+ + + + + +EL +++ TL + LQ
Sbjct: 838 KPLLKSAETEKEMATMKEEFQKT-------KDELAKSEAKRKELEEKLVTLVQEKNDLQ- 889
Query: 686 AVTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRN 745
+Q + NLL + D + + A++ +E+ E +
Sbjct: 890 --------LQVQAESENLLDAEERCDQLIKAKFQLEAKI------------KEVTERAED 929
Query: 746 QELLQSQLTEKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQS 805
+E + ++LT K +E+ S ++ + + E K + L +L+
Sbjct: 930 EEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENK--VKNLTEELSGLD 987
Query: 806 VEITKLQTEK-------QELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETK 858
I KL EK Q+ L +A V +T++ + + D+E + L++ K
Sbjct: 988 ETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLE----SSLEQEK 1043
Query: 859 ELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQ 918
+L+ ++ ER K + D + +IL E DK +L+ KK+ + + +D+
Sbjct: 1044 KLRVDL-----ERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDE 1098
Query: 919 KILSL--KNKLKDLG---HPVEEEDELESGDQEDEDDESEDPGKDLDHI 962
+ L L + K+K+L +EEE E E + + + D ++L+ +
Sbjct: 1099 QTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEEL 1147
Score = 54.3 bits (129), Expect = 5e-07
Identities = 56/318 (17%), Positives = 132/318 (41%), Gaps = 13/318 (4%)
Query: 632 SEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQV 691
SE K ++++ TL + + +N ++ +L L + ++ L + + LQ A Q +
Sbjct: 949 SELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQAL 1008
Query: 692 SQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIE-ELKRNQELLQ 750
+Q +D+ N L K Q + ++ R + ++E +LK QE +
Sbjct: 1009 DDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESIL 1068
Query: 751 SQLTEKDSMIENMKSSQTSGTNEQSSA----IVSARDSEQVAELKQELATLKSQLNSQSV 806
+K + E +K QS + + +++ EL+ + L+ ++ ++
Sbjct: 1069 DLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERA 1128
Query: 807 EITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKA 866
K + ++ + ++ E ++ +E G + E L ++ +E + +A
Sbjct: 1129 TRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEA 1188
Query: 867 L--------SEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQ 918
+ ++ + EQ+D+ L+ EK + +LEI D + + A+ ++
Sbjct: 1189 MVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEK 1248
Query: 919 KILSLKNKLKDLGHPVEE 936
+L+++L + EE
Sbjct: 1249 ICRTLEDQLSEARGKNEE 1266
Score = 36.6 bits (83), Expect = 0.12
Identities = 50/271 (18%), Positives = 113/271 (41%), Gaps = 38/271 (14%)
Query: 639 EEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQIQQ-H 697
EE++ TLEQ + + + + + +++ L Q ++L ++L+T + Q S+++
Sbjct: 1687 EELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDAS 1746
Query: 698 KDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKD 757
+D N + + + + ++ A M EELK+ Q+ K
Sbjct: 1747 RDARN-------AEEKAKKAITDAAMM--------------AEELKKEQDTSAHLERMKK 1785
Query: 758 SMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQE 817
++ + +K Q + A+ + +Q+ +L+ + L+ +L + K TE +
Sbjct: 1786 NLEQTVKDLQHRLDEAEQLALKGGK--KQIQKLETRIRELEFELEGEQ----KKNTESVK 1839
Query: 818 LLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTA---- 873
L+K E K + Q E + + D+ +L + K K + + E+ A
Sbjct: 1840 GLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQV---KVKSYKRQAEEADEQANAHLTK 1896
Query: 874 ---IKEQLDSSNSTIAILQTEKDKLELEITD 901
+ +L+ + I +++ +KL + D
Sbjct: 1897 FRKAQHELEEAEERADIAESQVNKLRAKTRD 1927
>gi|14165274 golgi-associated microtubule-binding protein HOOK3
[Homo sapiens]
Length = 718
Score = 64.7 bits (156), Expect = 4e-10
Identities = 69/313 (22%), Positives = 147/313 (46%), Gaps = 16/313 (5%)
Query: 631 SSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTAVTQQ 690
+S ++ +++ LEQ + + ++ EEL +++S L+ QN++L T
Sbjct: 237 NSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQQNDELTTL---- 292
Query: 691 VSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEEL-KRNQELL 749
+ Q KD+ ++L+ K ++ +G + + E++G LR +++ L ++N +
Sbjct: 293 ADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKK----KLEDLGDLRRQVKLLEEKNTMYM 348
Query: 750 QSQLT-EKDSMIENMKSSQTSGTNEQSSAIVS--ARDSEQVAELKQELATLKSQLNSQSV 806
Q+ ++ E++ N SQ Q + + + +S++ +L E LK +++S
Sbjct: 349 QNTVSLEEELRKANAARSQLETYKRQVVELQNRLSEESKKADKLDFEYKRLKEKVDSLQK 408
Query: 807 EITKLQTEKQELLQKTEAF--AKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEI 864
E +L+TE+ L + E ++ E Q T+ ++ + + L+A + T E++ ++
Sbjct: 409 EKDRLRTERDSLKETIEELRCVQAQEGQLTTQGLMPLGSQESSDSLAAEI-VTPEIREKL 467
Query: 865 KALSEERTAIK-EQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSL 923
L E +K Q S N IA+LQ+ D L + + E + L + ++ L
Sbjct: 468 IRLQHENKMLKLNQEGSDNEKIALLQSLLDDANLRKNELETENRLVNQRLLEVQSQVEEL 527
Query: 924 KNKLKDLGHPVEE 936
+ L+D G E+
Sbjct: 528 QKSLQDQGSKAED 540
Score = 46.6 bits (109), Expect = 1e-04
Identities = 61/291 (20%), Positives = 128/291 (43%), Gaps = 39/291 (13%)
Query: 638 EEEVKKTLEQHDNIVTHYKNMIR---EQDLQLEELRQQVSTLKCQNEQLQTAVTQQVSQI 694
+ ++KKT E+ + ++ + + + E D+Q+ L+++ S+L +N+ L + Q S I
Sbjct: 175 DRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLMERLNQSDS-I 233
Query: 695 QQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLT 754
+ +QL Q+ +Q EE RL ++ + E L+ +++
Sbjct: 234 EDPNSPAGRRHLQLQ------------TQLEQLQ-EETFRLEAAKDDYRIRCEELEKEIS 280
Query: 755 EKDSMIENMKSSQTSGTNEQSSAIVSARDSEQVAELKQELATLKSQLNSQSV---EITKL 811
E + + + + + V S++V++L+ ++ + K +L ++ L
Sbjct: 281 ELRQQNDELTTLADEAQSLKDEIDVLRHSSDKVSKLEGQVESYKKKLEDLGDLRRQVKLL 340
Query: 812 QTEKQELLQKT----EAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKAL 867
+ + +Q T E K+ + + ET + +++ RLS ++ +L E K L
Sbjct: 341 EEKNTMYMQNTVSLEEELRKANAARSQLETY-KRQVVELQNRLSEESKKADKLDFEYKRL 399
Query: 868 SEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQ 918
KE++DS LQ EKD+L E K+ ++L + A + Q
Sbjct: 400 -------KEKVDS-------LQKEKDRLRTERDSLKETIEELRCVQAQEGQ 436
Score = 35.0 bits (79), Expect = 0.34
Identities = 69/291 (23%), Positives = 122/291 (41%), Gaps = 61/291 (20%)
Query: 717 SYSEGAQMNGIQPEEIGRLREEIEELKR--------NQELLQSQLTEKDSMIENM--KSS 766
+Y + +N I+ E R +I LK+ N E+L Q+ + N+ + S
Sbjct: 51 AYFDENWLNRIKTEVGDNWRLKISNLKKILKGILDYNHEILGQQINDFTLPDVNLIGEHS 110
Query: 767 QTSGTNEQSSAIVS-ARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAF 825
+ I+ A + EQ E Q + ++ + Q V +T +Q EL+ K
Sbjct: 111 DAAELGRMLQLILGCAVNCEQKQEYIQAIMMMEESV--QHVVMTAIQ----ELMSKESPV 164
Query: 826 AKSVEVQGETETIIATKTTDVEGRLSA---LLQETKELKNEIKALSEERTAI-------K 875
+ + + + + T ++ LSA + Q EL ++ AL EE++++
Sbjct: 165 SAGNDAYVDLDRQLKKTTEELNEALSAKEEIAQRCHELDMQVAALQEEKSSLLAENQVLM 224
Query: 876 EQLDSSNSTI----------AILQTEKDKL-------------------ELEITDSK-KE 905
E+L+ S+S LQT+ ++L ELE S+ ++
Sbjct: 225 ERLNQSDSIEDPNSPAGRRHLQLQTQLEQLQEETFRLEAAKDDYRIRCEELEKEISELRQ 284
Query: 906 QDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPG 956
Q+D L LAD+ Q SLK+++ L H ++ +LE G E + ED G
Sbjct: 285 QNDELTTLADEAQ---SLKDEIDVLRHSSDKVSKLE-GQVESYKKKLEDLG 331
Score = 33.1 bits (74), Expect = 1.3
Identities = 32/146 (21%), Positives = 69/146 (47%), Gaps = 13/146 (8%)
Query: 612 EFTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQ 671
E V+EL+ K++ + + +KK LE+H + N ++++ +E+L
Sbjct: 519 EVQSQVEELQ----KSLQDQGSKAEDSVLLKKKLEEHLEKLHEANNELQKKRAIIEDLEP 574
Query: 672 QVSTLKCQNEQLQTAVTQQVSQIQQHKDQYNLL------KIQLGKDNQHQGSYSE-GAQM 724
+ + + E+LQ A+ ++ +++Q +++Y I+ Q+QG+ E A
Sbjct: 575 RFNNSSLKIEELQEALRKKEEEMKQMEERYKKYLEKAKSVIRTLDPKQNQGAAPEIQALK 634
Query: 725 NGIQPEE--IGRLREEIEELKRNQEL 748
N +Q + L +E E+ K +E+
Sbjct: 635 NQLQERDRLFHSLEKEYEKTKSQREM 660
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.353
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,415,697
Number of Sequences: 37866
Number of extensions: 1488354
Number of successful extensions: 15744
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 300
Number of HSP's successfully gapped in prelim test: 1031
Number of HSP's that attempted gapping in prelim test: 9193
Number of HSP's gapped (non-prelim): 4883
length of query: 962
length of database: 18,247,518
effective HSP length: 112
effective length of query: 850
effective length of database: 14,006,526
effective search space: 11905547100
effective search space used: 11905547100
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.