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Search of human proteins with 4505423
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505423 nephroblastoma overexpressed precursor [Homo
sapiens]
(357 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens] 774 0.0
gi|4503123 connective tissue growth factor [Homo sapiens] 393 e-109
gi|31542331 cysteine-rich, angiogenic inducer, 61 [Homo sapiens] 315 4e-86
gi|4507921 WNT1 inducible signaling pathway protein 1 isoform 1 ... 277 9e-75
gi|38202241 WNT1 inducible signaling pathway protein 3 isoform 3... 224 9e-59
gi|4507925 WNT1 inducible signaling pathway protein 3 isoform 1 ... 224 9e-59
gi|4507923 WNT1 inducible signaling pathway protein 2 precursor ... 219 4e-57
gi|18491000 WNT1 inducible signaling pathway protein 1 isoform 2... 144 2e-34
gi|37693519 BMP-binding endothelial regulator precursor protein ... 52 8e-07
gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens] 50 2e-06
gi|56090548 insulin-like growth factor binding protein-like 1 [H... 50 3e-06
gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens] 50 4e-06
gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens] 50 4e-06
gi|5901946 endothelial cell-specific molecule 1 isoform a precur... 50 4e-06
gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens] 50 4e-06
gi|24308541 HtrA serine peptidase 4 precursor [Homo sapiens] 50 4e-06
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 49 7e-06
gi|208022668 endothelial cell-specific molecule 1 isoform b prec... 49 7e-06
gi|110347437 latent transforming growth factor beta binding prot... 49 9e-06
gi|110347412 latent transforming growth factor beta binding prot... 49 9e-06
gi|110347431 latent transforming growth factor beta binding prot... 49 9e-06
gi|108773804 Fraser syndrome 1 [Homo sapiens] 48 2e-05
gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens] 46 6e-05
gi|62243068 insulin-like growth factor binding protein 3 isoform... 45 8e-05
gi|62243248 insulin-like growth factor binding protein 3 isoform... 45 8e-05
gi|40353769 chordin-like 2 [Homo sapiens] 45 8e-05
gi|22129776 HtrA serine peptidase 3 [Homo sapiens] 45 8e-05
gi|223029476 NEL-like protein 2 isoform d [Homo sapiens] 45 1e-04
gi|223029474 NEL-like protein 2 isoform c [Homo sapiens] 45 1e-04
gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens] 45 1e-04
>gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens]
Length = 357
Score = 774 bits (1999), Expect = 0.0
Identities = 357/357 (100%), Positives = 357/357 (100%)
Query: 1 MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDG 60
MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDG
Sbjct: 1 MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDG 60
Query: 61 CSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSG 120
CSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSG
Sbjct: 61 CSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSG 120
Query: 121 EKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDS 180
EKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDS
Sbjct: 121 EKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDS 180
Query: 181 LGGLTLAAYRPEATLGVEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQ 240
LGGLTLAAYRPEATLGVEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQ
Sbjct: 181 LGGLTLAAYRPEATLGVEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQ 240
Query: 241 TRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKNCTSLHTYKPRFCGVCSDGRC 300
TRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKNCTSLHTYKPRFCGVCSDGRC
Sbjct: 241 TRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKNCTSLHTYKPRFCGVCSDGRC 300
Query: 301 CTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHTNCPKNNEAFLQELELKTTRGKM 357
CTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHTNCPKNNEAFLQELELKTTRGKM
Sbjct: 301 CTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHTNCPKNNEAFLQELELKTTRGKM 357
>gi|4503123 connective tissue growth factor [Homo sapiens]
Length = 349
Score = 393 bits (1010), Expect = e-109
Identities = 173/325 (53%), Positives = 225/325 (69%), Gaps = 4/325 (1%)
Query: 21 LLLHLLGQVAATQRCPPQCPGRCPATP-PTCAPGVRAVLDGCSCCLVCARQRGESCSDLE 79
+LL L + A Q C C RCP P P C GV VLDGC CC VCA+Q GE C++ +
Sbjct: 15 VLLALCSRPAVGQNCSGPC--RCPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERD 72
Query: 80 PCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIG 139
PCD GL+CD + + + G+CTA +G C+F G +YRSGE FQ SCK+QCTC DG +G
Sbjct: 73 PCDPHKGLFCDFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVG 132
Query: 140 CVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDSLGGLTLAAYRPEATLGVEV 199
C+P C +DV LP P+CP PR+V++PG+CCE+W+C ++ ++ G LAAYR E T G +
Sbjct: 133 CMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDP 192
Query: 200 SDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDK 259
+ NC+ QTTEW+ACSK+CGMG STRVTN N C + KQ+RLCMVRPCE + E+ K
Sbjct: 193 TMIRANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEE-NIK 251
Query: 260 KGKKCLRTKKSLKAIHLQFKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQ 319
KGKKC+RT K K I + CTS+ TY+ +FCGVC+DGRCCTPH T T+ EF+C G+
Sbjct: 252 KGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGE 311
Query: 320 IVKKPVMVIGTCTCHTNCPKNNEAF 344
++KK +M I TC CH NCP +N+ F
Sbjct: 312 VMKKNMMFIKTCACHYNCPGDNDIF 336
>gi|31542331 cysteine-rich, angiogenic inducer, 61 [Homo sapiens]
Length = 381
Score = 315 bits (807), Expect = 4e-86
Identities = 160/364 (43%), Positives = 208/364 (57%), Gaps = 39/364 (10%)
Query: 14 QCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGE 73
+ L L LLHL +T CP C CP P CAPGV V DGC CC VCA+Q E
Sbjct: 7 RALALVVTLLHLTRLALST--CPAAC--HCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNE 62
Query: 74 SCSDLEPCDESSGLYCDRSADPSNQTGICTAV-EGDNCVFDGVIYRSGEKFQPSCKFQCT 132
CS +PCD + GL C+ A + GIC A EG C ++ IY++GE FQP+CK QCT
Sbjct: 63 DCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCT 122
Query: 133 CRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPD-------EEDSLGGLT 185
C DG +GC+P C ++ LP CP PR V+V G+CCE+W+C D ++D L G
Sbjct: 123 CIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKE 182
Query: 186 LA--AYRPEATLGVEV----SDSSV--------------------NCIEQTTEWTACSKS 219
L A E T E+ SS+ CI QTT W+ CSK+
Sbjct: 183 LGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKT 242
Query: 220 CGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFK 279
CG G STRVTN N +C ++K+TR+C VRPC Q P + KKGKKC +TKKS + + +
Sbjct: 243 CGTGISTRVTNDNPECRLVKETRICEVRPCGQ-PVYSSLKKGKKCSKTKKSPEPVRFTYA 301
Query: 280 NCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHTNCPK 339
C S+ Y+P++CG C DGRCCTP T+T++ F+C G+ K VM+I +C C+ NCP
Sbjct: 302 GCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPH 361
Query: 340 NNEA 343
NEA
Sbjct: 362 ANEA 365
>gi|4507921 WNT1 inducible signaling pathway protein 1 isoform 1
precursor [Homo sapiens]
Length = 367
Score = 277 bits (709), Expect = 9e-75
Identities = 132/307 (42%), Positives = 178/307 (57%), Gaps = 7/307 (2%)
Query: 40 PGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSAD-PSNQ 98
P CP +PP C GV + DGC CC +CA+Q G++C++ CD GLYCD S D P
Sbjct: 52 PCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYA 111
Query: 99 TGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAP 158
G+C V G CV DGV Y +G+ FQP+CK+ CTC DG +GC P C L V P CP P
Sbjct: 112 IGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLC-LRVRPPRLWCPHP 170
Query: 159 RKVEVPGECCEKWICGPDEEDSLGGLTLAAYRPEATLGV-EVSDSSVNCIEQTTEWTACS 217
R+V +PG CCE+W+C E+D+ A A V EV NCI T+ W+ CS
Sbjct: 171 RRVSIPGHCCEQWVC---EDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCS 227
Query: 218 KSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQ 277
SCG+G STR++N N QC +++RLC +RPC+ + K GKKCL + +++
Sbjct: 228 TSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLI-KAGKKCLAVYQPEASMNFT 286
Query: 278 FKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHTNC 337
C S +Y+P++CGVC D RCC P+ +KTI FQC G + V+ I C C+ +C
Sbjct: 287 LAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSC 346
Query: 338 PKNNEAF 344
N+ F
Sbjct: 347 RNPNDIF 353
>gi|38202241 WNT1 inducible signaling pathway protein 3 isoform 3
[Homo sapiens]
Length = 372
Score = 224 bits (571), Expect = 9e-59
Identities = 117/313 (37%), Positives = 165/313 (52%), Gaps = 23/313 (7%)
Query: 40 PGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSAD-PSNQ 98
P +CP P C PGV V DGC CC +CA+Q GE C++ + CD GLYCD S D P +
Sbjct: 69 PCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYE 128
Query: 99 TGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPE---PNC 155
TG+C + C F+ V Y +G+ FQP+ F C C G IGC P + +P+ +C
Sbjct: 129 TGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTP-----LFIPKLAGSHC 183
Query: 156 PAPRKVEVPGECCEKWICGPD---EEDSLGGLTLAAYRPEATLGVEVSDSSVNCIEQTTE 212
+ G+ ++ C + ++ S T+ AYR + + C+ Q T+
Sbjct: 184 SGAK----GGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIWKK------KCLVQATK 233
Query: 213 WTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTD-KKGKKCLRTKKSL 271
WT CS++CGMG S RVTN N CEM K+ RLC ++PC+ + KGK C T +
Sbjct: 234 WTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLS 293
Query: 272 KAIHLQFKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTC 331
KA F C+S +YKP FCG+C D RCC P+ +K I +F C K ++ I +C
Sbjct: 294 KAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSC 353
Query: 332 TCHTNCPKNNEAF 344
C NC + + F
Sbjct: 354 VCQRNCREPGDIF 366
>gi|4507925 WNT1 inducible signaling pathway protein 3 isoform 1
[Homo sapiens]
Length = 354
Score = 224 bits (571), Expect = 9e-59
Identities = 117/313 (37%), Positives = 165/313 (52%), Gaps = 23/313 (7%)
Query: 40 PGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSAD-PSNQ 98
P +CP P C PGV V DGC CC +CA+Q GE C++ + CD GLYCD S D P +
Sbjct: 51 PCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYE 110
Query: 99 TGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPE---PNC 155
TG+C + C F+ V Y +G+ FQP+ F C C G IGC P + +P+ +C
Sbjct: 111 TGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTP-----LFIPKLAGSHC 165
Query: 156 PAPRKVEVPGECCEKWICGPD---EEDSLGGLTLAAYRPEATLGVEVSDSSVNCIEQTTE 212
+ G+ ++ C + ++ S T+ AYR + + C+ Q T+
Sbjct: 166 SGAK----GGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIWKK------KCLVQATK 215
Query: 213 WTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTD-KKGKKCLRTKKSL 271
WT CS++CGMG S RVTN N CEM K+ RLC ++PC+ + KGK C T +
Sbjct: 216 WTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLS 275
Query: 272 KAIHLQFKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTC 331
KA F C+S +YKP FCG+C D RCC P+ +K I +F C K ++ I +C
Sbjct: 276 KAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSC 335
Query: 332 TCHTNCPKNNEAF 344
C NC + + F
Sbjct: 336 VCQRNCREPGDIF 348
>gi|4507923 WNT1 inducible signaling pathway protein 2 precursor
[Homo sapiens]
Length = 250
Score = 219 bits (557), Expect = 4e-57
Identities = 110/233 (47%), Positives = 134/233 (57%), Gaps = 6/233 (2%)
Query: 18 LTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSD 77
L F LL LL +V TQ CP C CP PP C GV VLDGC CC VCAR+ GE C
Sbjct: 10 LAFSLLCLLSKVR-TQLCPTPCT--CPWPPPRCPLGVPLVLDGCGCCRVCARRLGEPCDQ 66
Query: 78 LEPCDESSGLYCDRSADPSNQTGICTAVEGDN-CVFDGVIYRSGEKFQPSCKFQCTCRDG 136
L CD S GL C A P + +C E D+ C +G +YR GE FQP C +C C DG
Sbjct: 67 LHVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDG 126
Query: 137 QIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDSLGGLTLAAYRPEATLG 196
CVP C DV LP +CP PR+VEV G+CC +W+CG + LG L A P+ +
Sbjct: 127 GFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVCG--QGGGLGTQPLPAQGPQFSGL 184
Query: 197 VEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPC 249
V V C E +T W CS +CG+G +TRV+N+NR C + Q RLC+ RPC
Sbjct: 185 VSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPC 237
>gi|18491000 WNT1 inducible signaling pathway protein 1 isoform 2
precursor [Homo sapiens]
Length = 280
Score = 144 bits (362), Expect = 2e-34
Identities = 81/228 (35%), Positives = 113/228 (49%), Gaps = 20/228 (8%)
Query: 127 CKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKV--EVPGECCEKWICGPDEEDSLGGL 184
CK+ C C PRC L V L C + ++ C E IC P GL
Sbjct: 49 CKWPCECPPSP----PRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHR-----GL 99
Query: 185 --TLAAYRPEATLGV------EVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCE 236
+ RP +GV EV NCI T+ W+ CS SCG+G STR++N N QC
Sbjct: 100 YCDYSGDRPRYAIGVCAHAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCW 159
Query: 237 MLKQTRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKNCTSLHTYKPRFCGVCS 296
+++RLC +RPC+ + K GKKCL + +++ C S +Y+P++CGVC
Sbjct: 160 PEQESRLCNLRPCDVDIHTLI-KAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCM 218
Query: 297 DGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHTNCPKNNEAF 344
D RCC P+ +KTI FQC G + V+ I C C+ +C N+ F
Sbjct: 219 DNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIF 266
Score = 77.0 bits (188), Expect = 2e-14
Identities = 53/165 (32%), Positives = 69/165 (41%), Gaps = 29/165 (17%)
Query: 40 PGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSAD-PSNQ 98
P CP +PP C GV + DGC CC +CA+Q G++C++ CD GLYCD S D P
Sbjct: 52 PCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYA 111
Query: 99 TGICTAVEGD------NCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPE 152
G+C G+ NC + Y S + P C C L V
Sbjct: 112 IGVCAHAVGEVEAWHRNC----IAYTS--PWSP--------------CSTSCGLGVSTRI 151
Query: 153 PNCPAPRKVEVPGECCEKWICGPDEEDSL--GGLTLAAYRPEATL 195
N A E C C D + G LA Y+PEA++
Sbjct: 152 SNVNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASM 196
>gi|37693519 BMP-binding endothelial regulator precursor protein
[Homo sapiens]
Length = 685
Score = 52.0 bits (123), Expect = 8e-07
Identities = 43/148 (29%), Positives = 59/148 (39%), Gaps = 26/148 (17%)
Query: 42 RCPATPPTCAPGVRAVLDGCSCCLVCA------------RQRGESCSDLEPCDES----S 85
+CP CA ++ C C C + E C L C E S
Sbjct: 83 KCPVLSRDCALAIKQRGACCEQCKGCTYEGNTYNSSFKWQSPAEPCV-LRQCQEGVVTES 141
Query: 86 GLYCD-RSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQP--SCKFQCTCRDGQIGCVP 142
G+ C +P G+C CVF+GV Y+ GE+FQP S +C+C G+ CV
Sbjct: 142 GVRCVVHCKNPLEHLGMCCPT-CPGCVFEGVQYQEGEEFQPEGSKCTKCSCTGGRTQCVR 200
Query: 143 RCQLDVLLPEPNCPAPRKVEVPGECCEK 170
+ P +CP PG+CC K
Sbjct: 201 E-----VCPILSCPQHLSHIPPGQCCPK 223
Score = 30.8 bits (68), Expect = 1.9
Identities = 12/36 (33%), Positives = 18/36 (50%)
Query: 109 NCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRC 144
+C+F +Y +G F CTCRD + C +C
Sbjct: 237 SCLFRSDVYDNGSSFLYDNCTACTCRDSTVVCKRKC 272
Score = 28.5 bits (62), Expect = 9.7
Identities = 35/159 (22%), Positives = 51/159 (32%), Gaps = 38/159 (23%)
Query: 34 RCPPQCPGR----------CPATPPTCAPGVRAVLDGCSCC------LVCARQRGESCSD 77
+C P+C G+ C G + D C+ C +VC R+ CS
Sbjct: 219 QCCPKCLGQRKVFDLPFGSCLFRSDVYDNGSSFLYDNCTACTCRDSTVVCKRK----CSH 274
Query: 78 LEPCDESSGLYCDRSA--DPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRD 135
CD+ C+ P +C F I++ GE + C C
Sbjct: 275 PGGCDQGQEGCCEECLLRVPPEDIKVCK--------FGNKIFQDGEMWSSINCTICACVK 326
Query: 136 GQIGC-------VPRCQLDVLLPEPNCPAPRKVEVPGEC 167
G+ C + C +L C P E PG C
Sbjct: 327 GRTECRNKQCIPISSCPQGKILNRKGC-CPICTEKPGVC 364
>gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]
Length = 814
Score = 50.4 bits (119), Expect = 2e-06
Identities = 44/149 (29%), Positives = 56/149 (37%), Gaps = 25/149 (16%)
Query: 36 PPQCPGRCPATPPTCAPGVRAVLDGCSC------CLVCARQRGESCSDLEPCDESSGLYC 89
P PG+C P C +DG S C C Q G + PC +
Sbjct: 528 PQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAP---- 583
Query: 90 DRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKF-QPS--CKFQCTCRDGQIGCVPRCQL 146
A P G C + C F G Y SG F PS C+ C C G + C+ R +
Sbjct: 584 --CAHPL--PGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRL-CRCLSGNVQCLARRCV 638
Query: 147 DVLLPEPNCPAPRKVEVPGECCEKWICGP 175
+ PEP V +PGECC + P
Sbjct: 639 PLPCPEP-------VLLPGECCPQCPAAP 660
Score = 42.7 bits (99), Expect = 5e-04
Identities = 35/134 (26%), Positives = 45/134 (33%), Gaps = 23/134 (17%)
Query: 37 PQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPS 96
P C G C T G D C+ C G + +PC P
Sbjct: 133 PHCRG-CSQNGQTYGNGETFSPDACTTCRCL---EGTITCNQKPCPRG----------PC 178
Query: 97 NQTGICTAVEGDNCVFDGVIYRSGEKFQPSCK--FQCTCRDGQIGCVPRCQLDVLLPEPN 154
+ G C C ++G +Y G F S QCTC ++ C + L P
Sbjct: 179 PEPGACCPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRC-------MALKCPP 231
Query: 155 CPAPRKVEVPGECC 168
P P V PG CC
Sbjct: 232 SPCPEPVLRPGHCC 245
Score = 42.0 bits (97), Expect = 8e-04
Identities = 47/167 (28%), Positives = 61/167 (36%), Gaps = 35/167 (20%)
Query: 14 QCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVL---------DGCSCC 64
QCL + L V C PQCP PA PG D C C
Sbjct: 631 QCLARRCVPLPCPEPVLLPGECCPQCPA-APAPAGCPRPGAAHARHQEYFSPPGDPCRRC 689
Query: 65 LVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQ 124
L SC L PC + A P Q C + +G C++ G + SGE+F
Sbjct: 690 LCL--DGSVSCQRL-PCPPAP------CAHP-RQGPCCPSCDG--CLYQGKEFASGERFP 737
Query: 125 P---SCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECC 168
+C C C +G + C P+ L CP P + G+CC
Sbjct: 738 SPTAACHL-CLCWEGSVSCEPKACAPAL-----CPFPAR----GDCC 774
Score = 41.2 bits (95), Expect = 0.001
Identities = 56/226 (24%), Positives = 74/226 (32%), Gaps = 48/226 (21%)
Query: 10 CLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSC------ 63
CLR + C+ +CPP P C P + +G S
Sbjct: 217 CLRSRVRCMAL-------------KCPPSPCPEPVLRPGHCCPTCQGCTEGGSHWEHGQE 263
Query: 64 -------CLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVI 116
C +C G C C A P G C V D C +G
Sbjct: 264 WTTPGDPCRICRCLEGHIQCRQRECAS----LCPYPARPL--PGTCCPV-CDGCFLNGRE 316
Query: 117 YRSGEKFQPS--CKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICG 174
+RSGE C C C +G + C P LP P P ++PG+CC +C
Sbjct: 317 HRSGEPVGSGDPCS-HCRCANGSVQCEP-------LPCPPVPCRHPGKIPGQCCP--VCD 366
Query: 175 PDEEDSLGGLTLAAYR-PEATLGVEVS--DSSVNCIEQTTEWTACS 217
E + +R E L V S V+C EQ T C+
Sbjct: 367 GCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCA 412
Score = 38.9 bits (89), Expect = 0.007
Identities = 40/145 (27%), Positives = 48/145 (33%), Gaps = 40/145 (27%)
Query: 37 PQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPS 96
PQC G A P G R D C+ C+ C D +C A
Sbjct: 94 PQCWGLGRAWPE----GARWEPDACTACV---------CQD-------GAAHCGPQAHLP 133
Query: 97 NQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCP 156
+ G C +G Y +GE F P C C +G I C + P P P
Sbjct: 134 HCRG---------CSQNGQTYGNGETFSPDACTTCRCLEGTITCNQK-------PCPRGP 177
Query: 157 APRKVEVPGECCEKWICGPDEEDSL 181
P PG CC G D E L
Sbjct: 178 CPE----PGACCPHCKPGCDYEGQL 198
>gi|56090548 insulin-like growth factor binding protein-like 1 [Homo
sapiens]
Length = 278
Score = 50.1 bits (118), Expect = 3e-06
Identities = 34/89 (38%), Positives = 38/89 (42%), Gaps = 4/89 (4%)
Query: 34 RCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSA 93
+C P P CPA P APG+ A LD C CC C G SC GL C A
Sbjct: 37 KCGPCRPEGCPAPAPCPAPGISA-LDECGCCARCLGAEGASCGGRAGGRCGPGLVCASQA 95
Query: 94 DPS--NQTGICT-AVEGDNCVFDGVIYRS 119
+ TG+C A G C DG Y S
Sbjct: 96 AGAAPEGTGLCVCAQRGTVCGSDGRSYPS 124
>gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]
Length = 763
Score = 49.7 bits (117), Expect = 4e-06
Identities = 45/154 (29%), Positives = 63/154 (40%), Gaps = 25/154 (16%)
Query: 35 CP--PQCPGRCPATPPTCAPGVRAVL--DGCSCCLVCARQRGESCSDLEPCD---ESSGL 87
CP P C G CP G L D CS VC+ + G+ CD S+ L
Sbjct: 577 CPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS---VCSCKDGKIFCRRTACDCQNPSADL 633
Query: 88 YCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLD 147
+C D + T C G +YRSG+ + SC+ QC C +G++ C P
Sbjct: 634 FCCPECD-TRVTSQCLDQNGHK------LYRSGDNWTHSCQ-QCRCLEGEVDCWP----- 680
Query: 148 VLLPEPNCPAPRKVEVPGECCEKWICGPDEEDSL 181
L PN + GECC + + P D++
Sbjct: 681 --LTCPNLSCEYTAILEGECCPRCVSDPCLADNI 712
Score = 29.6 bits (65), Expect = 4.3
Identities = 24/109 (22%), Positives = 39/109 (35%), Gaps = 18/109 (16%)
Query: 61 CSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSG 120
C+C R SC L C + P + G C V C++ G + G
Sbjct: 295 CTCKSGAVECRRMSCPPLN---------CSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEG 345
Query: 121 EK-FQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECC 168
++ SC+ CR G + ++ + P NC + +CC
Sbjct: 346 QRILTKSCR---ECRGGVL-----VKITEMCPPLNCSEKDHILPENQCC 386
>gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
Length = 810
Score = 49.7 bits (117), Expect = 4e-06
Identities = 45/154 (29%), Positives = 63/154 (40%), Gaps = 25/154 (16%)
Query: 35 CP--PQCPGRCPATPPTCAPGVRAVL--DGCSCCLVCARQRGESCSDLEPCD---ESSGL 87
CP P C G CP G L D CS VC+ + G+ CD S+ L
Sbjct: 624 CPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS---VCSCKDGKIFCRRTACDCQNPSADL 680
Query: 88 YCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLD 147
+C D + T C G +YRSG+ + SC+ QC C +G++ C P
Sbjct: 681 FCCPECD-TRVTSQCLDQNGHK------LYRSGDNWTHSCQ-QCRCLEGEVDCWP----- 727
Query: 148 VLLPEPNCPAPRKVEVPGECCEKWICGPDEEDSL 181
L PN + GECC + + P D++
Sbjct: 728 --LTCPNLSCEYTAILEGECCPRCVSDPCLADNI 759
Score = 29.6 bits (65), Expect = 4.3
Identities = 24/109 (22%), Positives = 39/109 (35%), Gaps = 18/109 (16%)
Query: 61 CSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSG 120
C+C R SC L C + P + G C V C++ G + G
Sbjct: 295 CTCKSGAVECRRMSCPPLN---------CSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEG 345
Query: 121 EK-FQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECC 168
++ SC+ CR G + ++ + P NC + +CC
Sbjct: 346 QRILTKSCR---ECRGGVL-----VKITEMCPPLNCSEKDHILPENQCC 386
>gi|5901946 endothelial cell-specific molecule 1 isoform a precursor
[Homo sapiens]
Length = 184
Score = 49.7 bits (117), Expect = 4e-06
Identities = 41/132 (31%), Positives = 54/132 (40%), Gaps = 21/132 (15%)
Query: 13 KQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGV-RAVLDGCSCCLVCARQR 71
K L LT LL+ A + CP C ++ +P R VLD C CC VCA R
Sbjct: 2 KSVLLLTTLLVPAHLVAAWSNNYAVDCPQHCDSSECKSSPRCKRTVLDDCGCCRVCAAGR 61
Query: 72 GESC----SDLEPCDESSGLYCDRS--ADP-SNQTGICTAVEGDNCVFDGVIYRSGEKFQ 124
GE+C S ++ GL C S DP + GIC +C + F
Sbjct: 62 GETCYRTVSGMDGMKCGPGLRCQPSNGEDPFGEEFGIC-----KDCPYG--------TFG 108
Query: 125 PSCKFQCTCRDG 136
C+ C C+ G
Sbjct: 109 MDCRETCNCQSG 120
>gi|209571519 cysteine rich BMP regulator 2 isoform 1 [Homo sapiens]
Length = 1503
Score = 49.7 bits (117), Expect = 4e-06
Identities = 43/142 (30%), Positives = 54/142 (38%), Gaps = 25/142 (17%)
Query: 36 PPQCPGRCPATPPTCAPGVRAVLDGCSC------CLVCARQRGESCSDLEPCDESSGLYC 89
P PG+C P C +DG S C C Q G + PC +
Sbjct: 470 PQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAP---- 525
Query: 90 DRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKF-QPS--CKFQCTCRDGQIGCVPRCQL 146
A P G C + C F G Y SG F PS C+ C C G + C+ R +
Sbjct: 526 --CAHPL--PGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRL-CRCLSGNVQCLARRCV 580
Query: 147 DVLLPEPNCPAPRKVEVPGECC 168
+ PEP V +PGECC
Sbjct: 581 PLPCPEP-------VLLPGECC 595
Score = 43.1 bits (100), Expect = 4e-04
Identities = 41/159 (25%), Positives = 52/159 (32%), Gaps = 31/159 (19%)
Query: 35 CPPQCPGRCPATPPTCAPGVRAVLDGCS------------CCLVCARQRGESCSDL---- 78
CPP P P C P L CS C C C DL
Sbjct: 1002 CPPS--QLLPPGPQHCCPTCAEALSNCSEGLLGSELAPPDPCYTC------QCQDLTWLC 1053
Query: 79 --EPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDG 136
+ C E S +R P + +C A +CV G SGE++ C+C G
Sbjct: 1054 IHQACPELSCPLSERHTPPGSCCPVCRAPT-QSCVHQGREVASGERWTVDTCTSCSCMAG 1112
Query: 137 QIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGP 175
+ RCQ P P PG CC + + P
Sbjct: 1113 TV----RCQSQRCSPLSCGPDKAPALSPGSCCPRCLPRP 1147
Score = 42.0 bits (97), Expect = 8e-04
Identities = 47/168 (27%), Positives = 61/168 (36%), Gaps = 40/168 (23%)
Query: 14 QCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCA----------PGVRAVLDGCSC 63
QCL + L V C PQCP P A PG D C
Sbjct: 573 QCLARRCVPLPCPEPVLLPGECCPQCPAPAGCPRPGAAHARHQEYFSPPG-----DPCRR 627
Query: 64 CLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKF 123
CL SC L PC + A P Q C + +G C++ G + SGE+F
Sbjct: 628 CLCL--DGSVSCQRL-PCPPAP------CAHP-RQGPCCPSCDG--CLYQGKEFASGERF 675
Query: 124 QP---SCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECC 168
+C C C +G + C P+ L CP P + G+CC
Sbjct: 676 PSPTAACHL-CLCWEGSVSCEPKACAPAL-----CPFPAR----GDCC 713
Score = 40.8 bits (94), Expect = 0.002
Identities = 59/233 (25%), Positives = 77/233 (33%), Gaps = 63/233 (27%)
Query: 37 PQCPGRCPATPPTCAPGVRAVLDGCSCC--LVCARQ-RGESCSDLE------PCDESSGL 87
P C G C T G D C+ C L A Q +G SCS+L P E +
Sbjct: 133 PHCRG-CSQNGQTYGNGETFSPDACTTCRCLTGAVQCQGPSCSELNCLESCTPPGECCPI 191
Query: 88 YCDRSAD----------PSNQTGICTAVEG----------------------------DN 109
C P + IC +EG D
Sbjct: 192 CCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYPARPLPGTCCPVCDG 251
Query: 110 CVFDGVIYRSGEKFQPS--CKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGEC 167
C +G +RSGE C C C +G + C P LP P P ++PG+C
Sbjct: 252 CFLNGREHRSGEPVGSGDPCS-HCRCANGSVQCEP-------LPCPPVPCRHPGKIPGQC 303
Query: 168 CEKWICGPDEEDSLGGLTLAAYR-PEATLGVEVS--DSSVNCIEQTTEWTACS 217
C +C E + +R E L V S V+C EQ T C+
Sbjct: 304 CP--VCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCA 354
Score = 37.0 bits (84), Expect = 0.027
Identities = 43/197 (21%), Positives = 62/197 (31%), Gaps = 39/197 (19%)
Query: 61 CSCCLVCARQRGESCSDLEPCDESSGLYCDRSA--DPSNQTGICTAVEG----------- 107
C+ L RG+ C D + C+ Y DP +CT + G
Sbjct: 699 CAPALCPFPARGDCCPDCDGCEYLGESYLSNQEFPDPREPCNLCTCLGGFVTCGRRPCEP 758
Query: 108 -----------------DNCVFDGVIYRSGEKF----QPSCKFQCTCRDGQIGCVPRCQL 146
C + GV SGE P+C CTC++G + C +
Sbjct: 759 PGCSHPLIPSGHCCPTCQGCRYHGVTTASGETLPDPLDPTCSL-CTCQEGSMRCQKKPCP 817
Query: 147 DVLLPEPNCPAPRKVEVPGECC---EKWICGPDEEDSLGGLTLAAYRPEATLGVEVSDSS 203
L P P+ P P V C + G + E G + V +
Sbjct: 818 PALCPHPS-PGPCFCPVCHSCLSQGREHQDGEEFEGPAGSCEWCRCQAGQVSCVRLQCPP 876
Query: 204 VNCIEQTTEWTACSKSC 220
+ C Q TE +C C
Sbjct: 877 LPCKLQVTERGSCCPRC 893
Score = 35.8 bits (81), Expect = 0.061
Identities = 37/133 (27%), Positives = 44/133 (33%), Gaps = 38/133 (28%)
Query: 37 PQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPS 96
PQC G A P G R D C+ C+ C D +C A
Sbjct: 94 PQCWGLGRAWPE----GARWEPDACTACV---------CQD-------GAAHCGPQAHLP 133
Query: 97 NQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCV-PRCQLDVLLPEPNC 155
+ G C +G Y +GE F P C C G + C P C E NC
Sbjct: 134 HCRG---------CSQNGQTYGNGETFSPDACTTCRCLTGAVQCQGPSCS------ELNC 178
Query: 156 PAPRKVEVPGECC 168
PGECC
Sbjct: 179 --LESCTPPGECC 189
Score = 32.0 bits (71), Expect = 0.87
Identities = 36/147 (24%), Positives = 49/147 (33%), Gaps = 30/147 (20%)
Query: 35 CPPQCP-----GRCPATPPTCAPGVRAVLDGCSCCLVCARQRG--------ESCSDLEPC 81
C PQC GR + PG D C C+ + G C L C
Sbjct: 947 CCPQCSDCEHEGRKYEPGESFQPGA----DPCEVCICEPQPEGPPSLRCHRRQCPSLVGC 1002
Query: 82 DESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCV 141
S L P Q T E + +G++ E P + C C+D C+
Sbjct: 1003 PPSQLL------PPGPQHCCPTCAEALSNCSEGLL--GSELAPPDPCYTCQCQDLTWLCI 1054
Query: 142 PRCQLDVLLPEPNCPAPRKVEVPGECC 168
+ PE +CP + PG CC
Sbjct: 1055 HQA-----CPELSCPLSERHTPPGSCC 1076
>gi|24308541 HtrA serine peptidase 4 precursor [Homo sapiens]
Length = 476
Score = 49.7 bits (117), Expect = 4e-06
Identities = 40/113 (35%), Positives = 46/113 (40%), Gaps = 4/113 (3%)
Query: 10 CLRKQCLCLTFLLLHLLGQVAATQ-RCPPQC-PGRCPATPPTCAPGVRAVLDGCSCCLVC 67
CL L L +L + TQ CP C P RCPA P TCA G V D C CC VC
Sbjct: 14 CLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALP-TCALGTTPVFDLCRCCRVC 72
Query: 68 ARQRGESCSDLEPCDESSGLYCDRSADPS-NQTGICTAVEGDNCVFDGVIYRS 119
E C + + GL C + P T C + G C D Y S
Sbjct: 73 PAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTYPS 125
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 48.9 bits (115), Expect = 7e-06
Identities = 41/155 (26%), Positives = 62/155 (40%), Gaps = 47/155 (30%)
Query: 110 CVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVP-RCQLDVLLPEPNCPAPRKVEVPGECC 168
C +GV YR+ E++ +C C++ C C + +P N P GECC
Sbjct: 318 CYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPI---MPCSNATVP-----DGECC 369
Query: 169 EKWICGPDEEDSLGGLTLAAYRPEATLGVEVSDSSVNCIEQTTEWTACSKSCGMGFSTRV 228
+ C P SDS+ + +EWT+CS SCG G +
Sbjct: 370 PR--CWP------------------------SDSADDGWSPWSEWTSCSTSCGNG----I 399
Query: 229 TNRNRQCEMLK--------QTRLCMVRPCEQEPEQ 255
R R C+ L QTR C ++ C++ +Q
Sbjct: 400 QQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQ 434
>gi|208022668 endothelial cell-specific molecule 1 isoform b
precursor [Homo sapiens]
Length = 134
Score = 48.9 bits (115), Expect = 7e-06
Identities = 41/114 (35%), Positives = 50/114 (43%), Gaps = 10/114 (8%)
Query: 13 KQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGV-RAVLDGCSCCLVCARQR 71
K L LT LL+ A + CP C ++ +P R VLD C CC VCA R
Sbjct: 2 KSVLLLTTLLVPAHLVAAWSNNYAVDCPQHCDSSECKSSPRCKRTVLDDCGCCRVCAAGR 61
Query: 72 GESC----SDLEPCDESSGLYCDRS--ADP-SNQTGICTAVEGDNCVFDGVIYR 118
GE+C S ++ GL C S DP + GIC E D DG I R
Sbjct: 62 GETCYRTVSGMDGMKCGPGLRCQPSNGEDPFGEEFGICK--EHDMASGDGNIVR 113
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 48.5 bits (114), Expect = 9e-06
Identities = 86/344 (25%), Positives = 116/344 (33%), Gaps = 78/344 (22%)
Query: 33 QRCPPQC-PGRCPATPPT----CAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGL 87
+R PP C PGRC +P + C PG RA C V R DL C+ + G
Sbjct: 525 RRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGS 584
Query: 88 Y---CDRSADPSNQTGICTAVEGDNCV-FDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPR 143
+ C + C V D C G+ R K P F+C C G G
Sbjct: 585 FLCVCPAGYQAAPHGASCQDV--DECTQSPGLCGRGACKNLPG-SFRCVCPAGFRGSACE 641
Query: 144 CQLDVLLPEP-----------------NCPAPRKVEVPGECCEKWICGPDEEDSLGGLTL 186
+D EP CPA + PG C+ DE
Sbjct: 642 EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQ----DVDE--------C 689
Query: 187 AAYRPEATLG-VEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCM 245
A P T G E ++ S C+ C MGF +CE + +
Sbjct: 690 ARSPPPCTYGRCENTEGSFQCV------------CPMGFQPNTA--GSECEDVDE----- 730
Query: 246 VRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKNCTS-LHTYKPRFCGV--CSDGR-CC 301
CE P G++C+ + S Q + C S H ++ R V CS G C
Sbjct: 731 ---CENHLACP----GQECVNSPGS-----FQCRTCPSGHHLHRGRCTDVDECSSGAPPC 778
Query: 302 TPHNTKT-IQAEFQCSPGQIVKKPVMVIGTCTCHTNCPKNNEAF 344
PH T + F+CS + P G C C + + F
Sbjct: 779 GPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCF 822
Score = 28.9 bits (63), Expect = 7.4
Identities = 20/59 (33%), Positives = 24/59 (40%), Gaps = 22/59 (37%)
Query: 49 TCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEG 107
TCAPG R RG SC D++ C E C Q+GICT +G
Sbjct: 837 TCAPGYR------------PGPRGASCLDVDECSEED--LC--------QSGICTNTDG 873
>gi|110347412 latent transforming growth factor beta binding protein
4 isoform b [Homo sapiens]
Length = 1587
Score = 48.5 bits (114), Expect = 9e-06
Identities = 86/344 (25%), Positives = 116/344 (33%), Gaps = 78/344 (22%)
Query: 33 QRCPPQC-PGRCPATPPT----CAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGL 87
+R PP C PGRC +P + C PG RA C V R DL C+ + G
Sbjct: 555 RRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGS 614
Query: 88 Y---CDRSADPSNQTGICTAVEGDNCV-FDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPR 143
+ C + C V D C G+ R K P F+C C G G
Sbjct: 615 FLCVCPAGYQAAPHGASCQDV--DECTQSPGLCGRGACKNLPG-SFRCVCPAGFRGSACE 671
Query: 144 CQLDVLLPEP-----------------NCPAPRKVEVPGECCEKWICGPDEEDSLGGLTL 186
+D EP CPA + PG C+ DE
Sbjct: 672 EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQ----DVDE--------C 719
Query: 187 AAYRPEATLG-VEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCM 245
A P T G E ++ S C+ C MGF +CE + +
Sbjct: 720 ARSPPPCTYGRCENTEGSFQCV------------CPMGFQPNTA--GSECEDVDE----- 760
Query: 246 VRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKNCTS-LHTYKPRFCGV--CSDGR-CC 301
CE P G++C+ + S Q + C S H ++ R V CS G C
Sbjct: 761 ---CENHLACP----GQECVNSPGS-----FQCRTCPSGHHLHRGRCTDVDECSSGAPPC 808
Query: 302 TPHNTKT-IQAEFQCSPGQIVKKPVMVIGTCTCHTNCPKNNEAF 344
PH T + F+CS + P G C C + + F
Sbjct: 809 GPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCF 852
Score = 28.9 bits (63), Expect = 7.4
Identities = 20/59 (33%), Positives = 24/59 (40%), Gaps = 22/59 (37%)
Query: 49 TCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEG 107
TCAPG R RG SC D++ C E C Q+GICT +G
Sbjct: 867 TCAPGYR------------PGPRGASCLDVDECSEED--LC--------QSGICTNTDG 903
>gi|110347431 latent transforming growth factor beta binding protein
4 isoform a [Homo sapiens]
Length = 1624
Score = 48.5 bits (114), Expect = 9e-06
Identities = 86/344 (25%), Positives = 116/344 (33%), Gaps = 78/344 (22%)
Query: 33 QRCPPQC-PGRCPATPPT----CAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGL 87
+R PP C PGRC +P + C PG RA C V R DL C+ + G
Sbjct: 592 RRVPPPCAPGRCENSPGSFRCVCGPGFRAGPRAAECLDVDECHRVPPPCDLGRCENTPGS 651
Query: 88 Y---CDRSADPSNQTGICTAVEGDNCV-FDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPR 143
+ C + C V D C G+ R K P F+C C G G
Sbjct: 652 FLCVCPAGYQAAPHGASCQDV--DECTQSPGLCGRGACKNLPG-SFRCVCPAGFRGSACE 708
Query: 144 CQLDVLLPEP-----------------NCPAPRKVEVPGECCEKWICGPDEEDSLGGLTL 186
+D EP CPA + PG C+ DE
Sbjct: 709 EDVDECAQEPPPCGPGRCDNTAGSFHCACPAGFRSRGPGAPCQ----DVDE--------C 756
Query: 187 AAYRPEATLG-VEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCM 245
A P T G E ++ S C+ C MGF +CE + +
Sbjct: 757 ARSPPPCTYGRCENTEGSFQCV------------CPMGFQPNTA--GSECEDVDE----- 797
Query: 246 VRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKNCTS-LHTYKPRFCGV--CSDGR-CC 301
CE P G++C+ + S Q + C S H ++ R V CS G C
Sbjct: 798 ---CENHLACP----GQECVNSPGS-----FQCRTCPSGHHLHRGRCTDVDECSSGAPPC 845
Query: 302 TPHNTKT-IQAEFQCSPGQIVKKPVMVIGTCTCHTNCPKNNEAF 344
PH T + F+CS + P G C C + + F
Sbjct: 846 GPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGDFCF 889
Score = 28.9 bits (63), Expect = 7.4
Identities = 20/59 (33%), Positives = 24/59 (40%), Gaps = 22/59 (37%)
Query: 49 TCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEG 107
TCAPG R RG SC D++ C E C Q+GICT +G
Sbjct: 904 TCAPGYR------------PGPRGASCLDVDECSEED--LC--------QSGICTNTDG 940
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 47.8 bits (112), Expect = 2e-05
Identities = 41/146 (28%), Positives = 61/146 (41%), Gaps = 14/146 (9%)
Query: 28 QVAATQRCPP---QCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDES 84
Q+AA Q CP + PG C G CS VC+ GE +PC
Sbjct: 77 QIAANQCCPECVLRTPGSCHHEKKIHEHGTEWASSPCS---VCSCNHGEVRCTPQPCPPL 133
Query: 85 SGLYCDRSADPSNQT-GICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGC-VP 142
S + + + P +C + G C ++G +++ GE ++ S +C CR+G C
Sbjct: 134 SCGHQELAFIPEGSCCPVCVGL-GKPCSYEGHVFQDGEDWRLSRCAKCLCRNGVAQCFTA 192
Query: 143 RCQLDVLLPEPNCPAPRKVEVPGECC 168
+CQ P V VPG+CC
Sbjct: 193 QCQ-----PLFCNQDETVVRVPGKCC 213
Score = 39.3 bits (90), Expect = 0.005
Identities = 38/166 (22%), Positives = 56/166 (33%), Gaps = 37/166 (22%)
Query: 34 RCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCS------------DLEPC 81
RC PQ P P +C A + SCC VC G+ CS L C
Sbjct: 124 RCTPQ-----PCPPLSCGHQELAFIPEGSCCPVCVGL-GKPCSYEGHVFQDGEDWRLSRC 177
Query: 82 D--------------ESSGLYCDRSADPSNQTG-ICTAVEGDNCVFDGVIYRSGEKFQPS 126
+ L+C++ G C +C G +Y GE++ +
Sbjct: 178 AKCLCRNGVAQCFTAQCQPLFCNQDETVVRVPGKCCPQCSARSCSAAGQVYEHGEQWSEN 237
Query: 127 CKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWI 172
C C G++ RC LP + G+CCE+ +
Sbjct: 238 ACTTCICDRGEV----RCHKQACLPLRCGKGQSRARRHGQCCEECV 279
Score = 39.3 bits (90), Expect = 0.005
Identities = 36/144 (25%), Positives = 56/144 (38%), Gaps = 16/144 (11%)
Query: 34 RCPPQCPGR-CPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRS 92
+C PQC R C A G + + C+ C+ RGE + C L C +
Sbjct: 211 KCCPQCSARSCSAAGQVYEHGEQWSENACTTCIC---DRGEVRCHKQAC---LPLRCGKG 264
Query: 93 ADPSNQTGICT---AVEGDNCVFDGVIYRSGEKFQPS-CKFQCTCRDGQIGCVPRCQLDV 148
+ + G C +C +DGV+ E ++ S C+F C C GQ+ CQ
Sbjct: 265 QSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWKGSACEF-CMCDHGQV----TCQTGE 319
Query: 149 LLPEPNCPAPRKVEVPGECCEKWI 172
+ + G+CC + I
Sbjct: 320 CAKVECARDEELIHLDGKCCPECI 343
Score = 36.6 bits (83), Expect = 0.035
Identities = 57/244 (23%), Positives = 83/244 (34%), Gaps = 50/244 (20%)
Query: 6 STSFCLRKQCLCLTFLLLHL-LGQVAATQRCPPQCPGRCPATPPTCA-PGVRAVLDGC-- 61
+T C R + C L L G+ + R QC C + +C+ GV D
Sbjct: 240 TTCICDRGEVRCHKQACLPLRCGKGQSRARRHGQCCEECVSPAGSCSYDGVVRYQDEMWK 299
Query: 62 -SCCLVCARQRGE------SCSDLEPCDESSGLYCDRSADPS--NQTGICTAVEGDNCVF 112
S C C G+ C+ +E + ++ D P ++ G C E +
Sbjct: 300 GSACEFCMCDHGQVTCQTGECAKVECARDEELIHLDGKCCPECISRNGYCVYEETGEFMS 359
Query: 113 DGVI----YRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCP----APRKVEVP 164
GEK++ C CR Q+ C EP+CP +EV
Sbjct: 360 SNASEVKRIPEGEKWEDGPCKVCECRGAQVTCY----------EPSCPPCPVGTLALEVK 409
Query: 165 GECCEKWICGPDEEDSLGGLTLAAYRPEATLGVEVSDSSVNCIEQT----TEWTACSKSC 220
G+CC PD T P+ + D C + T W C SC
Sbjct: 410 GQCC------PD-------CTSVHCHPDCLTCSQSPDHCDLCQDPTKLLQNGW--CVHSC 454
Query: 221 GMGF 224
G+GF
Sbjct: 455 GLGF 458
>gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens]
Length = 480
Score = 45.8 bits (107), Expect = 6e-05
Identities = 25/57 (43%), Positives = 27/57 (47%), Gaps = 6/57 (10%)
Query: 35 CPPQC-PGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLE-PCDESSGLYC 89
CP +C P RCP P C G D C CC VC G +C E PC E GL C
Sbjct: 37 CPDRCEPARCPPQPEHCEGG--RARDACGCCEVCGAPEGAACGLQEGPCGE--GLQC 89
>gi|62243068 insulin-like growth factor binding protein 3 isoform
b precursor [Homo sapiens]
Length = 291
Score = 45.4 bits (106), Expect = 8e-05
Identities = 27/70 (38%), Positives = 31/70 (44%), Gaps = 5/70 (7%)
Query: 26 LGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCS-DLEPCDES 84
LG V + C + +C P CA VR GC CCL CA G+ C E C
Sbjct: 34 LGPVVRCEPCDARALAQCAPPPAVCAELVRE--PGCGCCLTCALSEGQPCGIYTERC--G 89
Query: 85 SGLYCDRSAD 94
SGL C S D
Sbjct: 90 SGLRCQPSPD 99
>gi|62243248 insulin-like growth factor binding protein 3 isoform
a precursor [Homo sapiens]
Length = 297
Score = 45.4 bits (106), Expect = 8e-05
Identities = 27/70 (38%), Positives = 31/70 (44%), Gaps = 5/70 (7%)
Query: 26 LGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCS-DLEPCDES 84
LG V + C + +C P CA VR GC CCL CA G+ C E C
Sbjct: 34 LGPVVRCEPCDARALAQCAPPPAVCAELVRE--PGCGCCLTCALSEGQPCGIYTERC--G 89
Query: 85 SGLYCDRSAD 94
SGL C S D
Sbjct: 90 SGLRCQPSPD 99
>gi|40353769 chordin-like 2 [Homo sapiens]
Length = 451
Score = 45.4 bits (106), Expect = 8e-05
Identities = 34/112 (30%), Positives = 51/112 (45%), Gaps = 28/112 (25%)
Query: 89 CDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQ---------PSCKFQCTCRDGQIG 139
C + +P +G+ + +C +G +Y+ GE F P+ C+C +GQI
Sbjct: 92 CPKCVEPHTPSGLRAPPK--SCQHNGTMYQHGEIFSAHELFPSRLPNQCVLCSCTEGQIY 149
Query: 140 C-VPRCQLDVLLPEPNCPAPRKVEVPGECCEKWIC------GPDEEDSLGGL 184
C + C PEP CPAP + +P CC+ C DEEDS+ L
Sbjct: 150 CGLTTC------PEPGCPAP--LPLPDSCCQ--ACKDEASEQSDEEDSVQSL 191
Score = 35.8 bits (81), Expect = 0.061
Identities = 26/77 (33%), Positives = 33/77 (42%), Gaps = 15/77 (19%)
Query: 110 CVFDGVIYRSGEKFQPSCK-------FQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVE 162
CV G Y GE + P+ + CTC DG+ CQ E C P K
Sbjct: 252 CVHGGKTYSHGEVWHPAFRAFGPLPCILCTCEDGR----QDCQRVTCPTEYPCRHPEK-- 305
Query: 163 VPGECCEKWICGPDEED 179
V G+CC+ IC D+ D
Sbjct: 306 VAGKCCK--ICPEDKAD 320
>gi|22129776 HtrA serine peptidase 3 [Homo sapiens]
Length = 453
Score = 45.4 bits (106), Expect = 8e-05
Identities = 29/77 (37%), Positives = 36/77 (46%), Gaps = 7/77 (9%)
Query: 11 LRKQCLCLTFLLLHLLGQVAATQRCPPQCP-GRCPATPPTCAPGVRAVLDGCSCCLVCAR 69
++ + L L L L + CP +C RCP+ P C G V D C+CCLVCA
Sbjct: 1 MQARALLLAALAALALAREPPAAPCPARCDVSRCPS--PRCPGGY--VPDLCNCCLVCAA 56
Query: 70 QRGESCSDL--EPCDES 84
GE C PC ES
Sbjct: 57 SEGEPCGGPLDSPCGES 73
>gi|223029476 NEL-like protein 2 isoform d [Homo sapiens]
Length = 839
Score = 45.1 bits (105), Expect = 1e-04
Identities = 40/153 (26%), Positives = 60/153 (39%), Gaps = 21/153 (13%)
Query: 34 RCP--PQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCD---ESSGLY 88
RCP C G C G VL+ C VC+ Q G CD + L+
Sbjct: 652 RCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS-VCSCQNGFVMCRRMVCDCENPTVDLF 710
Query: 89 CDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDV 148
C DP + C G+ +Y SG+ + +C+ QC C G++ C P
Sbjct: 711 CCPECDP-RLSSQCLHQNGET------LYNSGDTWVQNCQ-QCRCLQGEVDCWP------ 756
Query: 149 LLPEPNCPAPRKVEVPGECCEKWICGPDEEDSL 181
LP P+ + ECC + + P + D++
Sbjct: 757 -LPCPDVECEFSILPENECCPRCVTDPCQADTI 788
>gi|223029474 NEL-like protein 2 isoform c [Homo sapiens]
Length = 815
Score = 45.1 bits (105), Expect = 1e-04
Identities = 40/153 (26%), Positives = 60/153 (39%), Gaps = 21/153 (13%)
Query: 34 RCP--PQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCD---ESSGLY 88
RCP C G C G VL+ C VC+ Q G CD + L+
Sbjct: 628 RCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS-VCSCQNGFVMCRRMVCDCENPTVDLF 686
Query: 89 CDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDV 148
C DP + C G+ +Y SG+ + +C+ QC C G++ C P
Sbjct: 687 CCPECDP-RLSSQCLHQNGET------LYNSGDTWVQNCQ-QCRCLQGEVDCWP------ 732
Query: 149 LLPEPNCPAPRKVEVPGECCEKWICGPDEEDSL 181
LP P+ + ECC + + P + D++
Sbjct: 733 -LPCPDVECEFSILPENECCPRCVTDPCQADTI 764
>gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens]
Length = 816
Score = 45.1 bits (105), Expect = 1e-04
Identities = 40/153 (26%), Positives = 60/153 (39%), Gaps = 21/153 (13%)
Query: 34 RCP--PQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCD---ESSGLY 88
RCP C G C G VL+ C VC+ Q G CD + L+
Sbjct: 629 RCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS-VCSCQNGFVMCRRMVCDCENPTVDLF 687
Query: 89 CDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDV 148
C DP + C G+ +Y SG+ + +C+ QC C G++ C P
Sbjct: 688 CCPECDP-RLSSQCLHQNGET------LYNSGDTWVQNCQ-QCRCLQGEVDCWP------ 733
Query: 149 LLPEPNCPAPRKVEVPGECCEKWICGPDEEDSL 181
LP P+ + ECC + + P + D++
Sbjct: 734 -LPCPDVECEFSILPENECCPRCVTDPCQADTI 765
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.135 0.455
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,036,821
Number of Sequences: 37866
Number of extensions: 899971
Number of successful extensions: 3359
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 168
Number of HSP's that attempted gapping in prelim test: 2751
Number of HSP's gapped (non-prelim): 694
length of query: 357
length of database: 18,247,518
effective HSP length: 103
effective length of query: 254
effective length of database: 14,347,320
effective search space: 3644219280
effective search space used: 3644219280
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.