Search of human proteins with 4505217

Search of human proteins with 4505217

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505217 matrix metalloproteinase 3 preproprotein [Homo
sapiens]
         (477 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    992   0.0  
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   794   0.0  
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   526   e-149
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    501   e-142
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   495   e-140
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   490   e-138
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                483   e-136
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      476   e-134
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   425   e-119
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]   311   1e-84
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...   307   1e-83
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   303   3e-82
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]   294   1e-79
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...   283   3e-76
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...   256   2e-68
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    249   5e-66
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...   248   7e-66
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   234   1e-61
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   221   1e-57
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]      219   6e-57
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...   219   6e-57
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...   188   1e-47
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...   186   4e-47
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]   184   2e-46
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...   147   2e-35
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]          113   3e-25
gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]           96   9e-20
gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]           95   1e-19
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]       92   1e-18
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ...    86   1e-16

>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  992 bits (2564), Expect = 0.0
 Identities = 477/477 (100%), Positives = 477/477 (100%)

Query: 1   MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60
           MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV
Sbjct: 1   MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60

Query: 61  VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN 120
           VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN
Sbjct: 61  VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN 120

Query: 121 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV 180
           YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV
Sbjct: 121 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV 180

Query: 181 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 240
           LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY
Sbjct: 181 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 240

Query: 241 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS 300
           HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS
Sbjct: 241 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS 300

Query: 301 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF 360
           TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF
Sbjct: 301 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF 360

Query: 361 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP 420
           WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP
Sbjct: 361 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP 420

Query: 421 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477
           GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
Sbjct: 421 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  794 bits (2050), Expect = 0.0
 Identities = 373/477 (78%), Positives = 420/477 (88%), Gaps = 1/477 (0%)

Query: 1   MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60
           M  L  L+LLC+ VCSAYPL GAA+ ED++ +L Q+YLE YY+L+KDVKQF RRKDS  +
Sbjct: 1   MMHLAFLVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQF-RRKDSNLI 59

Query: 61  VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN 120
           VKKI+ MQKFLGLEVTGKLD+DTLEVMRKPRCGVPDVGHF +FPG+PKWRKTHLTYRIVN
Sbjct: 60  VKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVN 119

Query: 121 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV 180
           YTPDLP+DAVDSA+EKALKVWEEVTPLTFSRLYEGEADIMISFAV+EHGDFY FDGPG+ 
Sbjct: 120 YTPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHS 179

Query: 181 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 240
           LAHAY PGPG+ GD HFDDDE+WT+D +GTNLFLVAAHE+GHSLGLFHSANTEALMYPLY
Sbjct: 180 LAHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLY 239

Query: 241 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS 300
           +S T+L +FRLSQDD+NGIQSLYGPPP S E PLVPT+ VP     PA CDPALSFDA+S
Sbjct: 240 NSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIS 299

Query: 301 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF 360
           TLRGE L FKDR+FWR+S    EPE HLIS+FWPSLPS +DAAYEV S+D VFIFKGN+F
Sbjct: 300 TLRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEF 359

Query: 361 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP 420
           WAIRGNEV+AGYPRGIHTLGFPPT+RKIDAA+SDKEK KTYFF  DKYWRFDE   SME 
Sbjct: 360 WAIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQ 419

Query: 421 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477
           GFP+ IA+DFPG++ K+DAV + FGFFYFF+GSSQ EFDPNA+ VTH LKSNSWL+C
Sbjct: 420 GFPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  526 bits (1356), Expect = e-149
 Identities = 255/478 (53%), Positives = 340/478 (71%), Gaps = 13/478 (2%)

Query: 1   MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60
           M S P LLLL      ++        ++  ++LVQKYLE YY+LK D +Q  +R++SGPV
Sbjct: 1   MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV 60

Query: 61  VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN 120
           V+K+++MQ+F GL+VTGK D++TL+VM++PRCGVPDV  F    G P+W +THLTYRI N
Sbjct: 61  VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN 120

Query: 121 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV 180
           YTPDLP+  VD A+EKA ++W  VTPLTF+++ EG+ADIMISF   +H D  PFDGPG  
Sbjct: 121 YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN 180

Query: 181 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 240
           LAHA+ PGPGI GDAHFD+DE+WT +    NL  VAAHE+GHSLGL HS +  ALMYP Y
Sbjct: 181 LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY 240

Query: 241 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS 300
               D+   +L+QDDI+GIQ++YG   +       P +P+ P+  TP  CD  L+FDA++
Sbjct: 241 TFSGDV---QLAQDDIDGIQAIYGRSQN-------PVQPIGPQ--TPKACDSKLTFDAIT 288

Query: 301 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF 360
           T+RGE++ FKDR + R +    E EL+ IS FWP LP+G++AAYE   +D V  FKGN++
Sbjct: 289 TIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKY 348

Query: 361 WAIRGNEVRAGYPRGIH-TLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSME 419
           WA++G  V  GYP+ I+ + GFP TV+ IDAA+S++   KTYFFV +KYWR+DE + SM+
Sbjct: 349 WAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMD 408

Query: 420 PGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477
           PG+PK IA DFPGI  K+DAVF + GFFYFF G+ Q +FDP  K++    K+NSW NC
Sbjct: 409 PGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 466


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  501 bits (1291), Expect = e-142
 Identities = 241/477 (50%), Positives = 329/477 (68%), Gaps = 16/477 (3%)

Query: 1   MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60
           +K+LP LLLL V +  A+P+    +   T    VQ YLE +Y L  +  Q  R+  +  +
Sbjct: 4   LKTLPFLLLLHVQISKAFPVSSKEKNTKT----VQDYLEKFYQLPSNQYQSTRKNGTNVI 59

Query: 61  VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN 120
           V+K++EMQ+F GL VTGK + +TL++M+KPRCGVPD G F   PG PKW +T+LTYRI N
Sbjct: 60  VEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRN 119

Query: 121 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV 180
           YTP L +  V+ A++ A ++W   +PL F+R+ +GEADI I+F  R+HGD  PFDGP  +
Sbjct: 120 YTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGI 179

Query: 181 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 240
           LAHA+ PG GI GDAHFD +E WT  +   NLFLVAAHE GHSLGL HS++  ALMYP Y
Sbjct: 180 LAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNY 239

Query: 241 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS 300
            +  + + + L QDDI+GIQ++YG        P+ PT P  P+P     CDP+L+FDA++
Sbjct: 240 -AFRETSNYSLPQDDIDGIQAIYG----LSSNPIQPTGPSTPKP-----CDPSLTFDAIT 289

Query: 301 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF 360
           TLRGEIL FKDR+FWR+  +    E++ IS FWPSLP+G+ AAYE   +DL+F+FKGNQ+
Sbjct: 290 TLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQY 349

Query: 361 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP 420
           WA+ G ++  GYP+ I   GFP +V+ IDAA+    ++KTYFFV D++WR+D +R  MEP
Sbjct: 350 WALSGYDILQGYPKDISNYGFPSSVQAIDAAVF--YRSKTYFFVNDQFWRYDNQRQFMEP 407

Query: 421 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477
           G+PK I+  FPGI+SK+DAVF++  FF+ F+G     FD  A++VT   + N WLNC
Sbjct: 408 GYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNC 464


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  495 bits (1274), Expect = e-140
 Identities = 246/479 (51%), Positives = 329/479 (68%), Gaps = 11/479 (2%)

Query: 1   MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60
           MK L ILLL   A   A PL+ +   E  ++   ++YLE +Y L+ +     + K SG +
Sbjct: 1   MKFLLILLLQATA-SGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNL 59

Query: 61  VK-KIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIV 119
           +K KI+EMQ FLGL+VTG+LD+ TLE+M  PRCGVPDV HFR  PG P WRK ++TYRI 
Sbjct: 60  MKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRIN 119

Query: 120 NYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGN 179
           NYTPD+ ++ VD A+ KA +VW  VTPL FS++  G ADI++ FA   HGDF+ FDG G 
Sbjct: 120 NYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGG 179

Query: 180 VLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPL 239
           +LAHA+ PG GI GDAHFD+DE WT  + GTNLFL A HEIGHSLGL HS++ +A+M+P 
Sbjct: 180 ILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPT 239

Query: 240 YHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAV 299
           Y    D+  FRLS DDI GIQSLYG P ++   P        P+   PA CDP LSFDAV
Sbjct: 240 Y-KYVDINTFRLSADDIRGIQSLYGDPKENQRLP-------NPDNSEPALCDPNLSFDAV 291

Query: 300 STLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQ 359
           +T+  +I  FKDR FW K   + +  ++LISS WP+LPSG++AAYE+ +++ VF+FK ++
Sbjct: 292 TTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDK 351

Query: 360 FWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSME 419
           +W I        YP+ IH+ GFP  V+KIDAA+ +    +TYFFV+++YWR+DE+R  M+
Sbjct: 352 YWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMD 411

Query: 420 PGFPKQIAEDFPGIDSKIDAVF-EEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477
           PG+PK I ++F GI  KIDAVF  +  ++YFF GS+Q E+D   +++T TLKSNSW  C
Sbjct: 412 PGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC 470


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  490 bits (1261), Expect = e-138
 Identities = 236/477 (49%), Positives = 314/477 (65%), Gaps = 14/477 (2%)

Query: 4   LPILLLLCVAVCSAYPLDGAARGEDTS---MNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60
           L   L L    C A PL      +D S   +   ++YL +YY    ++   ++   +  +
Sbjct: 6   LAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYH-PTNLAGILKENAASSM 64

Query: 61  VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN 120
            +++REMQ F GLEVTGKLD +TL+VM+KPRCGVPDVG +  FP   KW K +LTYRIVN
Sbjct: 65  TERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVN 124

Query: 121 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV 180
           YTPD+    V+ A +KA KVW +VTPL F+RL++G ADIMISF ++EHGDFYPFDGP  +
Sbjct: 125 YTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGL 184

Query: 181 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 240
           LAHA+ PGP   GDAHFDDDE WT  + G NLFLVAAHE GHSLGL HS +  ALM+P+Y
Sbjct: 185 LAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY 244

Query: 241 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS 300
            + T  + F L  DD+ GIQSLYGP  + P          P  P TP  CDP+LS DA++
Sbjct: 245 -TYTGKSHFMLPDDDVQGIQSLYGPGDEDPN---------PKHPKTPDKCDPSLSLDAIT 294

Query: 301 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF 360
           +LRGE +IFKDR FWR   ++++ EL L  SFWP LP+ +DAAYE  S DL+FIF+G +F
Sbjct: 295 SLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKF 354

Query: 361 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP 420
           WA+ G ++  GYP+ I  LG P  V+KI AA+  ++  KT  F  ++ WR+D+  + M+ 
Sbjct: 355 WALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDK 414

Query: 421 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477
            +P+ I EDFPGI  K+DAV+E+ G+ YFF G  Q E+   + ++   + +NS L C
Sbjct: 415 DYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC 471


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score =  483 bits (1242), Expect = e-136
 Identities = 245/479 (51%), Positives = 314/479 (65%), Gaps = 16/479 (3%)

Query: 1   MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60
           MK L +L L  +   SA+PL      E+ +M L Q YL  +Y L+ +    V+ K+   +
Sbjct: 1   MKRLLLLFLFFITFSSAFPLVRMTENEE-NMQLAQAYLNQFYSLEIEGNHLVQSKNRSLI 59

Query: 61  VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFR-TFPGIPKWRKTHLTYRIV 119
             KIREMQ F GL VTGKLDS+TLE+M+ PRCGVPDVG +  T PG   WRK +LTYRI+
Sbjct: 60  DDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTLPG---WRKYNLTYRII 116

Query: 120 NYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYP-FDGPG 178
           NYTPD+ + AVD A+++ L+VW +VTPL F+++ +G ADIMI+F  R HG     FDGP 
Sbjct: 117 NYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPL 176

Query: 179 NVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYP 238
            VL HA+ PGPG+ GD HFD+DE WTKD  G NLFLVAAHE GH+LGL HS +  ALM+P
Sbjct: 177 GVLGHAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFP 236

Query: 239 LYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDA 298
            Y SL D  ++ LSQDDINGIQS+YG  P  P  P         EP  P  CDP L+FDA
Sbjct: 237 NYVSL-DPRKYPLSQDDINGIQSIYGGLPKEPAKP--------KEPTIPHACDPDLTFDA 287

Query: 299 VSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGN 358
           ++T R E++ FK RH WR      + E  LI+SFWPSLP+ + AAYE   +D + +FK  
Sbjct: 288 ITTFRREVMFFKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYE-NPRDKILVFKDE 346

Query: 359 QFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSM 418
            FW IRG  V   YP+ IHTLGFP  V+KIDAA+ DK   KTYFFV    WRFDE   +M
Sbjct: 347 NFWMIRGYAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTM 406

Query: 419 EPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477
           + GFP+++ + FPGI  ++DA F+  GFF+F  GS Q E+D   K +T  +++N+W  C
Sbjct: 407 DKGFPQRVVKHFPGISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQC 465


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  476 bits (1224), Expect = e-134
 Identities = 228/412 (55%), Positives = 298/412 (72%), Gaps = 13/412 (3%)

Query: 67  MQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLP 126
           MQ+F GL+VTGK D++TL+VM++PRCGVPDV  F    G P+W +THLTYRI NYTPDLP
Sbjct: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60

Query: 127 KDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYA 186
           +  VD A+EKA ++W  VTPLTF+++ EG+ADIMISF   +H D  PFDGPG  LAHA+ 
Sbjct: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120

Query: 187 PGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDL 246
           PGPGI GDAHFD+DE+WT +    NL  VAAHE+GHSLGL HS +  ALMYP Y    D+
Sbjct: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV 180

Query: 247 TRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEI 306
              +L+QDDI+GIQ++YG   +       P +P+ P+  TP  CD  L+FDA++T+RGE+
Sbjct: 181 ---QLAQDDIDGIQAIYGRSQN-------PVQPIGPQ--TPKACDSKLTFDAITTIRGEV 228

Query: 307 LIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGN 366
           + FKDR + R +    E EL+ IS FWP LP+G++AAYE   +D V  FKGN++WA++G 
Sbjct: 229 MFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQ 288

Query: 367 EVRAGYPRGIH-TLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQ 425
            V  GYP+ I+ + GFP TV+ IDAA+S++   KTYFFV +KYWR+DE + SM+PG+PK 
Sbjct: 289 NVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKM 348

Query: 426 IAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477
           IA DFPGI  K+DAVF + GFFYFF G+ Q +FDP  K++    K+NSW NC
Sbjct: 349 IAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 400


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  425 bits (1093), Expect = e-119
 Identities = 222/479 (46%), Positives = 299/479 (62%), Gaps = 9/479 (1%)

Query: 4   LPILLLLCVAVCSAYPLDGAA--RGEDTSMNLVQKYLENYYDLKK--DVKQFVRRKDSGP 59
           L + L++ +   +A P   AA  R    +  L Q YL+ YY  K+   + + V R  S  
Sbjct: 9   LAVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEMVAR-GSNS 67

Query: 60  VVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIV 119
           +++KI+E+Q F GL+VTGKLD  T+ V++KPRCGVPDV ++R FPG PKW+K  LTYRI 
Sbjct: 68  MIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKNTLTYRIS 127

Query: 120 NYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGN 179
            YTP +    VD AVE AL+ W    PL+F R+  GEADIMISF   +HGD YPFDGP  
Sbjct: 128 KYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRG 187

Query: 180 VLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPL 239
            LAHA+APG G+ GD HFD+ E+WT  T G NLF VAAHE GH+LGL HS +  ALMYP 
Sbjct: 188 TLAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDPSALMYPT 247

Query: 240 YHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAV 299
           Y    +   F L +DD+ GIQ+LYGP       P +P  P   +P  P  CD + SFDAV
Sbjct: 248 Y-KYKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAP-HHKPSIPDLCDSSSSFDAV 305

Query: 300 STLRGEILIFKDRHFWRKSLR-KLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGN 358
           + L  E+L+FKDR FWR+ +  +       I+S +P L S VDAAYEV  +   + FKG 
Sbjct: 306 TMLGKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGP 365

Query: 359 QFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSM 418
            +W  RG +++ G PR I+  GFP  V++IDAA+  +E  KT FFV D+Y+ +DE++  M
Sbjct: 366 HYWITRGFQMQ-GPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKM 424

Query: 419 EPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477
           E  +PK   E+F G++ +IDA  E  G+ YFF+G    ++D   + V   +KS+SW+ C
Sbjct: 425 EKDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKEDVVSVVKSSSWIGC 483


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score =  311 bits (796), Expect = 1e-84
 Identities = 191/465 (41%), Positives = 246/465 (52%), Gaps = 57/465 (12%)

Query: 64  IREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHF-------RTFPGIPKWRKTHLTY 116
           +  MQ+F G+ VTG LD  T+E M+KPRCGVPD  H        R      KWR+ H+TY
Sbjct: 111 VSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITY 170

Query: 117 RIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLY-------EGEADIMISFAVREHG 169
            I NYTP + +     A+ +A  VW++VTPLTF  +          EADIMI FA   HG
Sbjct: 171 SIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHG 230

Query: 170 DFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWT---KDTTGTNLFLVAAHEIGHSLGL 226
           D  PFDG G  LAHAY PGPGI GD HFD DE WT    +  G +LFLVA HE+GH+LGL
Sbjct: 231 DSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGL 290

Query: 227 FHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPP--PDSPETPLVPTEPV---- 280
            HS++  A+M P Y  + +   F+L QDD+ GIQ +YGPP  P  P  PL PT PV    
Sbjct: 291 EHSSDPSAIMAPFYQYM-ETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPL-PTLPVRRIH 348

Query: 281 ---------------------PPEPGTPAN-CDPALSFDAVSTLRGEILIFKDRHFWR-K 317
                                P  PGT  N CD   +F+ V+  RGE+ +FKDR FWR +
Sbjct: 349 SPSERKHERQPRPPRPPLGDRPSTPGTKPNICDG--NFNTVALFRGEMFVFKDRWFWRLR 406

Query: 318 SLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIH 377
           + R  E     I  FW  LP+ +DAAYE      VF FKG+++W  +   V  GYP  + 
Sbjct: 407 NNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVF-FKGDKYWVFKEVTVEPGYPHSLG 465

Query: 378 TLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKI 437
            LG       ID A+  +   KTYFF  ++YWR+ E+R + +PG+PK I   + GI    
Sbjct: 466 ELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITV-WKGIPQAP 524

Query: 438 DAVF--EEFGFFYFFTGSSQLEFDPNAKKVTHTLKSN---SWLNC 477
              F  +E  + YF+ G    +FD     V      N    W+ C
Sbjct: 525 QGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGC 569


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score =  307 bits (787), Expect = 1e-83
 Identities = 193/509 (37%), Positives = 266/509 (52%), Gaps = 66/509 (12%)

Query: 6   ILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIR 65
           +L +LC  VC          G +   N V+ +L+ Y  L     +    + +  +   + 
Sbjct: 26  LLWILCATVC----------GTEQYFN-VEVWLQKYGYLPPTDPRMSVLRSAETMQSALA 74

Query: 66  EMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVG------HFR----TFPGIPKWRKTHLT 115
            MQ+F G+ +TGK+D +T++ M+KPRCGVPD        H R       G  KW+  H+T
Sbjct: 75  AMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTG-QKWQHKHIT 133

Query: 116 YRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTF-----SRLYEG--EADIMISFAVREH 168
           Y I N TP +       A+ +A  VW+ VTPLTF     S L  G  + DI I FA   H
Sbjct: 134 YSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFH 193

Query: 169 GDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWT---KDTTGTNLFLVAAHEIGHSLG 225
           GD  PFDG G  LAHAY PGPGI GD HFD DE WT    +  G +LFLVA HE+GH+LG
Sbjct: 194 GDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALG 253

Query: 226 LFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPP----PDSPETPLVPTE--- 278
           L HS +  A+M P Y  + +   F+L  DD+ GIQ +YGPP    P +   P VP     
Sbjct: 254 LEHSNDPTAIMAPFYQYM-ETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSI 312

Query: 279 ----------PVPPEPGT---------PANCDPALSFDAVSTLRGEILIFKDRHFWR-KS 318
                     P PP P T         P  CD   +F+ ++ LR E+ +FKD+ FWR ++
Sbjct: 313 PPADPRKNDRPKPPRPPTGRPSYPGAKPNICDG--NFNTLAILRREMFVFKDQWFWRVRN 370

Query: 319 LRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHT 378
            R ++     I+ FW  LP  +DA YE +  + VF FKGN++W  +   ++ GYP  + T
Sbjct: 371 NRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVF-FKGNKYWVFKDTTLQPGYPHDLIT 429

Query: 379 LGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKID 438
           LG       ID+AI  ++  KTYFF  D+YWR+ E+  +M+PG+PK I   + GI     
Sbjct: 430 LGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITV-WKGIPESPQ 488

Query: 439 AVF--EEFGFFYFFTGSSQLEFDPNAKKV 465
             F  +E GF YF+ G    +F+    KV
Sbjct: 489 GAFVHKENGFTYFYKGKEYWKFNNQILKV 517


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  303 bits (775), Expect = 3e-82
 Identities = 196/520 (37%), Positives = 261/520 (50%), Gaps = 73/520 (14%)

Query: 5   PILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKI 64
           P LL L + +     L  AA  ED  ++  + +L  Y  L +  +     + +  +   +
Sbjct: 27  PRLLPLLLVLLGCLGLGVAA--EDAEVH-AENWLRLYGYLPQPSRHMSTMRSAQILASAL 83

Query: 65  REMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIP-----------KWRKTH 113
            EMQ+F G+ VTG LD +T E M++PRCGVPD    R    +            KW   H
Sbjct: 84  AEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHH 143

Query: 114 LTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRL-YEG-------EADIMISFAV 165
           LT+ I NYT  L       AV +A +VWE+ TPL F  + YE        EADIM+ FA 
Sbjct: 144 LTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFAS 203

Query: 166 REHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTT---GTNLFLVAAHEIGH 222
             HGD  PFDG G  LAHAY PGPG+ GD HFD DE WT  +T   G NLFLVA HE+GH
Sbjct: 204 GFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGH 263

Query: 223 SLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPE--------TPL 274
           +LGL HS+N  A+M P Y    D+  F+L +DD+ GIQ LYG P   P+        TP 
Sbjct: 264 ALGLEHSSNPNAIMAPFYQ-WKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPR 322

Query: 275 VPTEPV------------------PPEPGTPAN--------------CDPALSFDAVSTL 302
            P  P                   PP+PG P                CD    FD V+ L
Sbjct: 323 RPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDG--DFDTVAML 380

Query: 303 RGEILIFKDRHFWR-KSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFW 361
           RGE+ +FK R FWR +  R L+     I  FW  LP  + AAYE      VF FKG+++W
Sbjct: 381 RGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVF-FKGDRYW 439

Query: 362 AIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPG 421
             R   +  GYP+ + + G      +ID AI  +    T+FF ED+YWRF+E+    +PG
Sbjct: 440 LFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPG 499

Query: 422 FPKQIAEDFPGIDSKIDAVF--EEFGFFYFFTGSSQLEFD 459
           +PK I+  + GI +     F   +  + YF+ G+   +FD
Sbjct: 500 YPKPISV-WQGIPASPKGAFLSNDAAYTYFYKGTKYWKFD 538


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score =  294 bits (752), Expect = 1e-79
 Identities = 181/450 (40%), Positives = 243/450 (54%), Gaps = 42/450 (9%)

Query: 64  IREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPD---------VGHFRTFPGIPKWRKTHL 114
           I  MQKF GL+VTGK D+DT++ MR+PRCGVPD         V   R      KW+   +
Sbjct: 65  IAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEI 124

Query: 115 TYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRL--------YEGEADIMISFAVR 166
           T+ I NYTP + + A   A+ KA +VWE  TPL F  +        +E +ADIMI FA  
Sbjct: 125 TFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEG 184

Query: 167 EHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWT---KDTTGTNLFLVAAHEIGHS 223
            HGD  PFDG G  LAHAY PGP I GD HFD  E WT   +D  G ++FLVA HE+GH+
Sbjct: 185 FHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHA 244

Query: 224 LGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYG----------PPPDSPETP 273
           LGL HS++  A+M P Y  + D   F L  DD  GIQ LYG          P P +   P
Sbjct: 245 LGLEHSSDPSAIMAPFYQWM-DTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRP 303

Query: 274 LVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWR-KSLRKLEPELHLISSF 332
            VP +P  P  G P  CD   +FD V+ LRGE+ +FK+R FWR ++ + ++     I  F
Sbjct: 304 SVPDKPKNPTYG-PNICDG--NFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF 360

Query: 333 WPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAI 392
           W  LP+ ++ AYE      VF FKG++ W      +  GYP+ I  LG      KIDAA+
Sbjct: 361 WRGLPASINTAYERKDGKFVF-FKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAAL 419

Query: 393 SDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVF--EEFGFFYFF 450
                 KTYFF  +KY+RF+E+  +++  +PK I + + GI       F   +  F YF+
Sbjct: 420 FWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEGIPESPRGSFMGSDEVFTYFY 478

Query: 451 TGSSQLEFDPNAKKVTHTLKSNS---WLNC 477
            G+   +F+    KV      ++   W+ C
Sbjct: 479 KGNKYWKFNNQKLKVEPGYPKSALRDWMGC 508


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score =  283 bits (723), Expect = 3e-76
 Identities = 190/517 (36%), Positives = 260/517 (50%), Gaps = 59/517 (11%)

Query: 4   LPILLLLCVAV---CSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60
           LP+LLLL +     C+A     A R ED S+ +  ++L  +  L        + +    +
Sbjct: 23  LPLLLLLALGTRGGCAAPA--PAPRAEDLSLGV--EWLSRFGYLPPADPTTGQLQTQEEL 78

Query: 61  VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHF------RTFPGIPKWRKTHL 114
            K I  MQ+F GLE TG LD  TL +M+ PRC +PD+         R  P   KW K +L
Sbjct: 79  SKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQARRRRQAPAPTKWNKRNL 138

Query: 115 TYRIVNYTPDLP--KDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFY 172
           ++R+  +  D P   D V + +  ALKVW ++ PL F  +    ADI I F+  +H D Y
Sbjct: 139 SWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGY 198

Query: 173 PFDGPGNVLAHAYAPG-PGINGDAHFDDDEQWT---KDTTGTNLFLVAAHEIGHSLGLFH 228
           PFDGPG  +AHA+ PG     GD HFDDDE WT    D  G +LF VA HE GH++GL H
Sbjct: 199 PFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSH 258

Query: 229 SANTEALMYPLYHS-LTDLTRFRLSQDDINGIQSLYG------PPPDSPETPLVPTEP-- 279
            A   ++M P Y   + D  R+ L  +D   +  LYG      P     E PL+P  P  
Sbjct: 259 VAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDN 318

Query: 280 ---VPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWR----KSLRKLEP-ELHLISS 331
               PP    P  C  +  FDAV+ +RGE   FK ++FWR    + L  L+P ++H    
Sbjct: 319 RSSAPPRKDVPHRC--STHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMH---R 373

Query: 332 FWPSLP---SGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKI 388
           FW  LP     VDA YE TS   +  FKG+++W  + N V  GYPR +     PP    I
Sbjct: 374 FWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSDFSLPP--GGI 431

Query: 389 DAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKI-DAVFEEFGFF 447
           DAA S    ++TYFF +  YWR+D+    M+PG+P Q +  + G+ S + DA+    G  
Sbjct: 432 DAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGAS 490

Query: 448 YFFTG-------SSQLEFDPNAKKVTHTLKSNSWLNC 477
           YFF G         +LE  P   + T    +  WL C
Sbjct: 491 YFFRGQEYWKVLDGELEVAPGYPQST----ARDWLVC 523


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score =  256 bits (655), Expect = 2e-68
 Identities = 165/397 (41%), Positives = 213/397 (53%), Gaps = 34/397 (8%)

Query: 87  MRKPRCGVPDVGHFRTFPGIPK--------WRKTHLTYRIVNYTPDLPKDAVDSAVEKAL 138
           +R PRCGVPD     +     K        W KT LTYRI+ +   L ++ V   + +AL
Sbjct: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134

Query: 139 KVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFD 198
           KVW +VTPLTF+ ++EG ADIMI FA   HGD  PFDGPG +LAHA+ P     GD HFD
Sbjct: 135 KVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFD 194

Query: 199 DDEQWT-KDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDIN 257
            DE WT  D  GT+L  VAAHE GH LGL H+   +ALM   Y     L+   LS DD  
Sbjct: 195 YDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLS---LSPDDCR 251

Query: 258 GIQSLYGPPPDS---------PETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILI 308
           G+Q LYG P  +         P+  +   E  P EP  P +   A SFDAVST+RGE+  
Sbjct: 252 GVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEA-SFDAVSTIRGELFF 310

Query: 309 FKDRHFWRKSLRKLEPEL-HLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNE 367
           FK    WR    +L+P    L S  W  LPS VDAA+E  ++  ++ F+G Q+W   G +
Sbjct: 311 FKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFE-DAQGHIWFFQGAQYWVYDGEK 369

Query: 368 VRAGYPRGIHTLG---FPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPK 424
              G P  +  LG   FP       A +   EKNK YFF    YWRF      ++   P+
Sbjct: 370 PVLG-PAPLTELGLVRFPVHA----ALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPR 424

Query: 425 QIAEDFPGIDSKIDAVFEEF-GFFYFFTGSSQLEFDP 460
           + A D+ G+ S+IDA F++  G+ YF  G    +FDP
Sbjct: 425 R-ATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  249 bits (635), Expect = 5e-66
 Identities = 131/269 (48%), Positives = 169/269 (62%), Gaps = 10/269 (3%)

Query: 4   LPILLLLCVAVCS-AYPLDGAARG-EDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVV 61
           L +L  +C+   S A PL   A G  +      Q YL+ +Y    + K      ++  + 
Sbjct: 3   LTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETK------NANSLE 56

Query: 62  KKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNY 121
            K++EMQKF GL +TG L+S  +E+M+KPRCGVPDV  +  FP  PKW    +TYRIV+Y
Sbjct: 57  AKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSY 116

Query: 122 TPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVL 181
           T DLP   VD  V KAL +W +  PL F ++  G ADIMI FA   HGD YPFDGPGN L
Sbjct: 117 TRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTL 176

Query: 182 AHAYAPGPGINGDAHFDDDEQWTKDTT-GTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 240
           AHA+APG G+ GDAHFD+DE+WT  ++ G N    A HE+GHSLG+ HS++  A+MYP Y
Sbjct: 177 AHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTY 236

Query: 241 HSLTDLTRFRLSQDDINGIQSLYGPPPDS 269
            +  D   F+LSQDDI GIQ LYG   +S
Sbjct: 237 GN-GDPQNFKLSQDDIKGIQKLYGKRSNS 264


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score =  248 bits (634), Expect = 7e-66
 Identities = 165/452 (36%), Positives = 226/452 (50%), Gaps = 43/452 (9%)

Query: 64  IREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDV--------GHFRTFPGIPKWRKTHLT 115
           I+ MQ+F GL  TG++D  T+  MRKPRC +PDV           R       W+K  LT
Sbjct: 62  IKVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLT 121

Query: 116 YRIVNY--TPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEG---EADIMISFAVREHGD 170
           +R+ ++  +  L ++ V   +  AL  W   + LTF  +      E DI+I FA   H D
Sbjct: 122 WRVRSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQD 181

Query: 171 FYPFDGPGNVLAHAYAPGPG-INGDAHFDDDEQWT---KDTTGTNLFLVAAHEIGHSLGL 226
            YPFDG G  LAHA+ PG   I+GD HFDD+E WT   KD  GT+LF VA HE GH+LGL
Sbjct: 182 SYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGL 241

Query: 227 FHSANTEALMYPLYHS-LTDLTRFRLSQDDINGIQSLYGPPPDSP-----ETPLVPTEPV 280
            HS+   ++M P Y   + D  ++RLSQDD +G+Q LYG  P +P       PL P  P 
Sbjct: 242 GHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAP-PPQ 300

Query: 281 PPEPGT-------PANCDPALSFDAVSTLRGEILIFKDRHFWR--KSLRKLEPELHLISS 331
           PP   T       P  C+   +FDA++ +RGE   FK   FWR   S + + P    +  
Sbjct: 301 PPASPTHSPSFPIPDRCEG--NFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHR 358

Query: 332 FWPSLPSG---VDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKI 388
           FW  LP+    V AAY       + +F G QFW  +  ++  G  R +  LG PP   ++
Sbjct: 359 FWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTELGLPPG-EEV 416

Query: 389 DAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFY 448
           DA  S  +  KTY     +YWR+DE     +PG+P+ ++       S  D      G  Y
Sbjct: 417 DAVFSWPQNGKTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTY 476

Query: 449 FFTGSSQLEFDPNAKKVTHTL---KSNSWLNC 477
           FF G+    F  N+ K           +WL+C
Sbjct: 477 FFKGAHYWRFPKNSIKTEPDAPQPMGPNWLDC 508


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  234 bits (597), Expect = 1e-61
 Identities = 159/444 (35%), Positives = 220/444 (49%), Gaps = 68/444 (15%)

Query: 6   ILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIR 65
           +L +LC  VC          G +   N V+ +L+ Y  L     +    + +  +   + 
Sbjct: 26  LLWILCATVC----------GTEQYFN-VEVWLQKYGYLPPTDPRMSVLRSAETMQSALA 74

Query: 66  EMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVG------HFR----TFPGIPKWRKTHLT 115
            MQ+F G+ +TGK+D +T++ M+KPRCGVPD        H R       G  KW+  H+T
Sbjct: 75  AMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTG-QKWQHKHIT 133

Query: 116 YRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTF-----SRLYEG--EADIMISFAVREH 168
           Y I N TP +       A+ +A  VW+ VTPLTF     S L  G  + DI I FA   H
Sbjct: 134 YSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFH 193

Query: 169 GDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWT---KDTTGTNLFLVAAHEIGHSLG 225
           GD  PFDG G  LAHAY PGPGI GD HFD DE WT    +  G +LFLVA HE+GH+LG
Sbjct: 194 GDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALG 253

Query: 226 LFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGP----PPDSPETPLVP----- 276
           L HS +  A+M P Y  + +   F+L  DD+ GIQ +YGP    PP +   P VP     
Sbjct: 254 LEHSNDPTAIMAPFYQYM-ETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSI 312

Query: 277 --------TEPVPPEPGT---------PANCDPALSFDAVSTLRGEILIFKDRHFWR-KS 318
                     P PP P T         P  CD   +F+ ++ LR E+ +FKD+ FWR ++
Sbjct: 313 PPADPRKNDRPKPPRPPTGRPSYPGAKPNICDG--NFNTLAILRREMFVFKDQWFWRVRN 370

Query: 319 LRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFI-FKGNQFWAIRGNEVRAGYPRGIH 377
            R ++     I+ FW  LP  +DA YE +  + VF   KG+       + ++ G+    H
Sbjct: 371 NRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKVKGDTL-----SIIQDGWLYKYH 425

Query: 378 TLGFPPTVRKIDAAISDKEKNKTY 401
                   + +       EK+KTY
Sbjct: 426 WKWILEQRQSVPVLSRQTEKHKTY 449



 Score = 32.7 bits (73), Expect = 0.74
 Identities = 18/55 (32%), Positives = 29/55 (52%), Gaps = 3/55 (5%)

Query: 397 KNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEF-GFFYFF 450
           + + + F +  +WR   + N +  G+P QI   + G+   IDAV+E   G F FF
Sbjct: 354 RREMFVFKDQWFWRV--RNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  221 bits (563), Expect = 1e-57
 Identities = 154/455 (33%), Positives = 224/455 (49%), Gaps = 27/455 (5%)

Query: 37  YLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPD 96
           YL  Y  L+K ++     K    + + +R  Q+   L V+G+LD  T   MR+PRCG+ D
Sbjct: 31  YLSQYGYLQKPLEGSNNFKPED-ITEALRAFQEASELPVSGQLDDATRARMRQPRCGLED 89

Query: 97  VGHFRTFPGI--PKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYE 154
             + +T   +   +WRK HLT+RI+N    LP     +A+ +A + W  V PLTF  +  
Sbjct: 90  PFNQKTLKYLLLGRWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQA 149

Query: 155 GEADIMISFAVREHG-DFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDT-TGTNL 212
           G ADI +SF  R+       FDGPG VLAHA  P     G  HFD+DE WT+ T  G NL
Sbjct: 150 GAADIRLSFHGRQSSYCSNTFDGPGRVLAHADIPE---LGSVHFDEDEFWTEGTYRGVNL 206

Query: 213 FLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGP------P 266
            ++AAHE+GH+LGL HS  ++ALM P+Y        F+L  DD+ GIQ+LYG        
Sbjct: 207 RIIAAHEVGHALGLGHSRYSQALMAPVYEGYR--PHFKLHPDDVAGIQALYGKKSPVIRD 264

Query: 267 PDSPETPLVPTEPVPPEPG-TPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPE 325
            +  ET L    PVP EP   P  C   L    +   RG+   FK  + W  S     P 
Sbjct: 265 EEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP-RGKTYAFKGDYVWTVSDSGPGP- 322

Query: 326 LHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTV 385
           L  +S+ W  LP  +DAA        +  FKG++ W     ++  G+P+ ++ +      
Sbjct: 323 LFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNRV-----E 377

Query: 386 RKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFE-EF 444
             +DAA+      K + F    YW++DE   +    +PK I   F G+ ++  A    + 
Sbjct: 378 PNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQD 437

Query: 445 GFFYFFTGSS--QLEFDPNAKKVTHTLKSNSWLNC 477
           G  YFF G    +L      +K      S++W++C
Sbjct: 438 GRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHC 472


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score =  219 bits (557), Expect = 6e-57
 Identities = 119/289 (41%), Positives = 166/289 (57%), Gaps = 13/289 (4%)

Query: 195 AHFDDDEQWTK-DTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQ 253
           A++DDD +W      G +LFLVAAHE GH++GL HS +  ALM P+Y   T    FRLSQ
Sbjct: 329 ANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIY---TYTKNFRLSQ 385

Query: 254 DDINGIQSLYGPPPDSPETPLVPTEPVPP-EPGTPANCDPALSFDAVSTLRGEILIFKDR 312
           DDI GIQ LYG  PD      + T P P   P TP  C   + FD ++ +RGEI  FKDR
Sbjct: 386 DDIKGIQELYGASPDID----LGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDR 441

Query: 313 HFWRKSLRKLEPELHL-ISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAG 371
             WR    + +P   L +++FWP LP  +DA YE   ++    F GN++W    + +  G
Sbjct: 442 FIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERG 501

Query: 372 YPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFP 431
           YP+ + +LG PP V+++DAA +  +  KTY F  DK+WR++E +  M+PGFPK IA+ + 
Sbjct: 502 YPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWN 561

Query: 432 GIDSKIDAV--FEEFGFFYFFTGSSQLEFD-PNAKKVTHTLKSNSWLNC 477
            I   +DAV   +  G  YFF G+  L+ +  + K V      + WL C
Sbjct: 562 AIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 610



 Score =  196 bits (499), Expect = 3e-50
 Identities = 91/169 (53%), Positives = 116/169 (68%), Gaps = 6/169 (3%)

Query: 36  KYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVP 95
           +YL  +Y   K+       KD+      +++MQKF GL  TG LD +T+E MRKPRCG P
Sbjct: 2   QYLNTFYGCPKESCNLFVLKDT------LKKMQKFFGLPQTGDLDQNTIETMRKPRCGNP 55

Query: 96  DVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEG 155
           DV ++  FP  PKW K  +TYRI+ YTPDL  + VD A  +A +VW +VTPL FSR+++G
Sbjct: 56  DVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDG 115

Query: 156 EADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWT 204
           EADIMI+F   EHGD YPFDG   +LAHA+APG G+ GD+HFDDDE WT
Sbjct: 116 EADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 164


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score =  219 bits (557), Expect = 6e-57
 Identities = 119/289 (41%), Positives = 166/289 (57%), Gaps = 13/289 (4%)

Query: 195 AHFDDDEQWTK-DTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQ 253
           A++DDD +W      G +LFLVAAHE GH++GL HS +  ALM P+Y   T    FRLSQ
Sbjct: 379 ANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIY---TYTKNFRLSQ 435

Query: 254 DDINGIQSLYGPPPDSPETPLVPTEPVPP-EPGTPANCDPALSFDAVSTLRGEILIFKDR 312
           DDI GIQ LYG  PD      + T P P   P TP  C   + FD ++ +RGEI  FKDR
Sbjct: 436 DDIKGIQELYGASPDID----LGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDR 491

Query: 313 HFWRKSLRKLEPELHL-ISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAG 371
             WR    + +P   L +++FWP LP  +DA YE   ++    F GN++W    + +  G
Sbjct: 492 FIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERG 551

Query: 372 YPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFP 431
           YP+ + +LG PP V+++DAA +  +  KTY F  DK+WR++E +  M+PGFPK IA+ + 
Sbjct: 552 YPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWN 611

Query: 432 GIDSKIDAV--FEEFGFFYFFTGSSQLEFD-PNAKKVTHTLKSNSWLNC 477
            I   +DAV   +  G  YFF G+  L+ +  + K V      + WL C
Sbjct: 612 AIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 660



 Score =  199 bits (505), Expect = 6e-51
 Identities = 93/176 (52%), Positives = 118/176 (67%), Gaps = 6/176 (3%)

Query: 29  TSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMR 88
           T   L  +YL  +Y   K+       KD+      +++MQKF GL  TG LD +T+E MR
Sbjct: 45  TDKELAVQYLNTFYGCPKESCNLFVLKDT------LKKMQKFFGLPQTGDLDQNTIETMR 98

Query: 89  KPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLT 148
           KPRCG PDV ++  FP  PKW K  +TYRI+ YTPDL  + VD A  +A +VW +VTPL 
Sbjct: 99  KPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLR 158

Query: 149 FSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWT 204
           FSR+++GEADIMI+F   EHGD YPFDG   +LAHA+APG G+ GD+HFDDDE WT
Sbjct: 159 FSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 214


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score =  188 bits (477), Expect = 1e-47
 Identities = 155/498 (31%), Positives = 212/498 (42%), Gaps = 55/498 (11%)

Query: 23  AARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSD 82
           A RG        + +LE Y  L + V    +   S      IR  Q    L V+G LD  
Sbjct: 25  AERGGQELRKEAEAFLEKYGYLNEQVP---KAPTSTRFSDAIRAFQWVSQLPVSGVLDRA 81

Query: 83  TLEVMRKPRCGVPDVGHFRTFPGI----------------------PKWRKTHLTYRIVN 120
           TL  M +PRCGV D   +  +                          KW K HL+YR+VN
Sbjct: 82  TLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVN 141

Query: 121 YTPDLPKDAVDSAVEKALKVWEEVTPLTF-SRLYEGEADIMISFAVREHGDFY--PFDGP 177
           +   LP+ AV  AV  A ++W  V+ L F      G ADI ++F   +H D     FDGP
Sbjct: 142 WPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGP 201

Query: 178 GNVLAHAYAPGPGINGDAHFDDDEQWT-KDTTGTNLFLVAAHEIGHSLGLFHSANTEALM 236
           G  LAHA+ P     G+AHFD DE+W+     G NLF+V AHEIGH+LGL HS    ALM
Sbjct: 202 GGALAHAFLPR---RGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALM 258

Query: 237 YPLYHSLTDLTRFRLSQDDINGIQSLYGPP---------PDSPETPLVPTEPVPPEPGTP 287
            P Y  L       LS DD+  +QSLYG P         P    T     +   P+   P
Sbjct: 259 APYYKRLG--RDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRP 316

Query: 288 ANCDPAL---SFDAVSTLR-GEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAA 343
               P     SFDA++  R  ++ IFK  HFW  +      E   +   W  LP  ++AA
Sbjct: 317 ETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAA 376

Query: 344 YEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFF 403
               +    + FKG + W  RG +   G P+     G P   R  DAA+      +   F
Sbjct: 377 AVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLP---RHPDAALFFPPLRRLILF 433

Query: 404 VEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKID-AVFEEFGFFYFFTGSSQLEFDPNA 462
              +Y+        +EP +P+ + +D+ GI  ++  A+    G   FF        D   
Sbjct: 434 KGARYYVLARGGLQVEPYYPRSL-QDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAK 492

Query: 463 KKVTHT---LKSNSWLNC 477
            + T +        W+ C
Sbjct: 493 LQATTSGRWATELPWMGC 510


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  186 bits (472), Expect = 4e-47
 Identities = 106/254 (41%), Positives = 136/254 (53%), Gaps = 19/254 (7%)

Query: 15  CSAYPLDGAA--RGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLG 72
           C A P+  AA  +G D        ++E Y+       QF   K   P++ +  + Q    
Sbjct: 15  CFAVPVPPAADHKGWD--------FVEGYFH------QFFLTKKESPLLTQETQTQLLQQ 60

Query: 73  LEVTGK--LDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAV 130
               G   LD     ++ +P CGVPD       PG  KW K  LTYRI+NY  D+   AV
Sbjct: 61  FHRNGTDLLDMQMHALLHQPHCGVPDGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAV 120

Query: 131 DSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPG 190
             ++  A+ +W  VTPL F ++  G+ADI +SF    H D +PFDGPG +L HA+ P  G
Sbjct: 121 KDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSG 180

Query: 191 INGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFR 250
             G  HFD +E W+   TG NLFLVA HEIGHSLGL HS N  ++MYP Y    D   F+
Sbjct: 181 NPGVVHFDKNEHWSASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYW-YHDPRTFQ 239

Query: 251 LSQDDINGIQSLYG 264
           LS DDI  IQ LYG
Sbjct: 240 LSADDIQRIQHLYG 253


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score =  184 bits (466), Expect = 2e-46
 Identities = 97/208 (46%), Positives = 124/208 (59%), Gaps = 13/208 (6%)

Query: 6   ILLLLCVAVCSAYP---------LDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKD 56
           +L+LL +  C A P           G  R   T   L ++YL  Y    +  +     K 
Sbjct: 8   VLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRY-GYTRVAEMRGESKS 66

Query: 57  SGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTY 116
            GP +  +   QK L L  TG+LDS TL+ MR PRCGVPD+G F+TF G  KW   ++TY
Sbjct: 67  LGPALLLL---QKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITY 123

Query: 117 RIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDG 176
            I NY+ DLP+  +D A  +A  +W  VTPLTF+R+Y  +ADI+I F V EHGD YPFDG
Sbjct: 124 WIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDG 183

Query: 177 PGNVLAHAYAPGPGINGDAHFDDDEQWT 204
              +LAHA+ PGPGI GDAHFDDDE W+
Sbjct: 184 KDGLLAHAFPPGPGIQGDAHFDDDELWS 211



 Score =  130 bits (328), Expect = 2e-30
 Identities = 93/303 (30%), Positives = 133/303 (43%), Gaps = 54/303 (17%)

Query: 195 AHFDDDEQWTK-DTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQ 253
           ++FD D++W      G +LFLVAAHE GH+LGL HS+  EALMYP+Y          L +
Sbjct: 377 SNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPP---LHK 433

Query: 254 DDINGIQSLYGPPPDSPETPLVPTEPVPPEPGT--------------------------- 286
           DD+NGI+ LYGP P+    P   T P P  P T                           
Sbjct: 434 DDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGP 493

Query: 287 --PANCDPALS----------------FDAVSTLRGEILIFKDRHFWRKSL-RKLEPE-L 326
             P    P+ +                FDA++ +  ++ +FKD  +WR S  R   P+  
Sbjct: 494 TGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGP 553

Query: 327 HLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVR 386
            LI+  WP+LP  +D+ +E      +F F G Q W   G  V    PR +  LG    V 
Sbjct: 554 FLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLG--PRRLDKLGLGADVA 611

Query: 387 KIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGF 446
           ++  A+    + K   F   + WRFD K   ++P    ++   FPG+      VF+    
Sbjct: 612 QVTGALR-SGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYREK 670

Query: 447 FYF 449
            YF
Sbjct: 671 AYF 673


>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score =  147 bits (372), Expect = 2e-35
 Identities = 139/493 (28%), Positives = 209/493 (42%), Gaps = 113/493 (22%)

Query: 60  VVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDV-----------------GHFRT 102
           + + +R  Q+   L  +G+LD+ TL  M +PRCGVPD+                    R 
Sbjct: 85  LAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRR 144

Query: 103 FPGIPK------WR--------------KTHLTYRIVNYTPDLPKDAVDSA--VEKALKV 140
            P  P       W+              K  L++R++           D    V  A ++
Sbjct: 145 SPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRM 204

Query: 141 WEEVTPLTFSR--LYEGEA-DIMISFAVREH-GDFYPFDGPGNVLAHAYAPGPGINGDAH 196
           W EVTPL F       G A DI + F    H G    FDG G   AHA+  G     D H
Sbjct: 205 WSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIH 259

Query: 197 FDDDEQWTKDT--TGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQD 254
           FDDDE +T  T  TG +L  VA HEIGH LGL H+  T ++M P Y  +     F L   
Sbjct: 260 FDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNY--IPQEPAFELDWS 317

Query: 255 DINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLR---GEILI--- 308
           D   IQ LYG    S +T                      +FD +   R   GE+++   
Sbjct: 318 DRKAIQKLYGSCEGSFDT----------------------AFDWIRKERNQYGEVMVRFS 355

Query: 309 ---FKDRHFW----RKSLRKLEPELHLISSFWPSLPS-GVDAAYEVTS--KDLVFIFKGN 358
              F++  +W    R +  +    + +++  WP +P+  +DA   + +  +D  + F+GN
Sbjct: 356 TYFFRNSWYWLYENRNNRTRYGDPIQILTG-WPGIPTHNIDAFVHIWTWKRDERYFFQGN 414

Query: 359 QFW--------AIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWR 410
           Q+W        A+  +E    YP+ I   GFP     +D A  D+ +   YFF E   + 
Sbjct: 415 QYWRYDSDKDQALTEDEQGKSYPKLISE-GFPGIPSPLDTAFYDRRQKLIYFFKESLVFA 473

Query: 411 FDEKRNSMEPGFPKQIAEDFPGIDSK------IDAVFEEFGF--FYFFTGSSQLEFDPNA 462
           FD  RN +   +PK+I E FP +  +      ID+ +  + +   +FF G++  +   + 
Sbjct: 474 FDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDK 533

Query: 463 KKVTHTLKSNSWL 475
            K     + NSWL
Sbjct: 534 DK-----QQNSWL 541


>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 358

 Score =  113 bits (283), Expect = 3e-25
 Identities = 66/187 (35%), Positives = 96/187 (51%), Gaps = 45/187 (24%)

Query: 36  KYLEN-YYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGV 94
           KYLEN YY+LK ++ Q  R++DS PV++K+++MQ F GL+                    
Sbjct: 146 KYLENCYYNLKSEINQIGRQRDSSPVLEKLKQMQNFFGLKDQ------------------ 187

Query: 95  PDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYE 154
                                    NY P+LP++ VD A  KA ++W   + LTF+R +E
Sbjct: 188 -------------------------NYMPNLPQEDVDRATGKAFELWSNASALTFTRDFE 222

Query: 155 GEADIMISFA-VREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLF 213
            E DI++SF  + +  D  PF G    LAHA+ PGPGI GD HFD+DE  TKD   +  +
Sbjct: 223 SEGDIILSFVFLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFRSSKHW 282

Query: 214 LVAAHEI 220
           +V   ++
Sbjct: 283 VVQEDQL 289



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 44/113 (38%), Positives = 70/113 (61%), Gaps = 9/113 (7%)

Query: 328 LISSFWPSLPSGVDAAY---EVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHT-LGFPP 383
           L  +F P    G D  +   E  +KD    F+ ++ W ++ +++ +GYPR +++   FP 
Sbjct: 250 LAHAFPPGPGIGGDVHFDNDETRTKD----FRSSKHWVVQEDQLLSGYPRDVYSSFVFPE 305

Query: 384 TVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSK 436
            V+KIDAAI +K+  KT+FFV ++YWR+DE   S++ G+PK I +D PGI  K
Sbjct: 306 RVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPK-IIDDLPGISKK 357


>gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score = 95.5 bits (236), Expect = 9e-20
 Identities = 49/117 (41%), Positives = 71/117 (60%), Gaps = 7/117 (5%)

Query: 105 GIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFA 164
           GI KW++        NY P+LP++ VD A  KA ++W + + LTF+R +E E DI++SF 
Sbjct: 19  GIQKWQEDQ------NYMPNLPQEDVDRATGKAFELWSKASALTFTRDFESEGDIILSFV 72

Query: 165 -VREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEI 220
            + +  D  PF G    LAHA+ PGPGI GD HFD+DE  TKD   +  ++V   ++
Sbjct: 73  FLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFRSSKHWVVQEDQL 129



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 44/113 (38%), Positives = 70/113 (61%), Gaps = 9/113 (7%)

Query: 328 LISSFWPSLPSGVDAAY---EVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHT-LGFPP 383
           L  +F P    G D  +   E  +KD    F+ ++ W ++ +++ +GYPR +++   FP 
Sbjct: 90  LAHAFPPGPGIGGDVHFDNDETRTKD----FRSSKHWVVQEDQLLSGYPRDVYSSFVFPE 145

Query: 384 TVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSK 436
            V+KIDAAI +K+  KT+FFV ++YWR+DE   S++ G+PK I +D PGI  K
Sbjct: 146 RVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPK-IIDDLPGISKK 197


>gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 49/117 (41%), Positives = 70/117 (59%), Gaps = 7/117 (5%)

Query: 105 GIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFA 164
           GI KW++        NY P+LP++ VD A  KA ++W   + LTF+R +E E DI++SF 
Sbjct: 19  GIQKWQEDQ------NYMPNLPQEDVDRATGKAFELWSNASALTFTRDFESEGDIILSFV 72

Query: 165 -VREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEI 220
            + +  D  PF G    LAHA+ PGPGI GD HFD+DE  TKD   +  ++V   ++
Sbjct: 73  FLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFRSSKHWVVQEDQL 129



 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 44/113 (38%), Positives = 70/113 (61%), Gaps = 9/113 (7%)

Query: 328 LISSFWPSLPSGVDAAY---EVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHT-LGFPP 383
           L  +F P    G D  +   E  +KD    F+ ++ W ++ +++ +GYPR +++   FP 
Sbjct: 90  LAHAFPPGPGIGGDVHFDNDETRTKD----FRSSKHWVVQEDQLLSGYPRDVYSSFVFPE 145

Query: 384 TVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSK 436
            V+KIDAAI +K+  KT+FFV ++YWR+DE   S++ G+PK I +D PGI  K
Sbjct: 146 RVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPK-IIDDLPGISKK 197


>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
          Length = 390

 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 66/180 (36%), Positives = 94/180 (52%), Gaps = 27/180 (15%)

Query: 104 PGIPKWRKTHLTYRIVNYTPDL--PKDAVDSAVEKALKVWEEVTPLTFSRLY-EGEADIM 160
           P   +W   +LTYRI+++  +L  P++    A+  A ++W +V+P +F  +  E  +D+ 
Sbjct: 83  PARLRWDHFNLTYRILSFPRNLLSPRET-RRALAAAFRMWSDVSPFSFREVAPEQPSDLR 141

Query: 161 ISFAVREHGD------FYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTG----- 209
           I F    H D       + FDGP   LAHA+ P    +G  HFDD E W    T      
Sbjct: 142 IGFYPINHTDCLVSALHHCFDGPTGELAHAFFPP---HGGIHFDDSEYWVLGPTRYSWKK 198

Query: 210 ----TNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFR-LSQDDINGIQSLYG 264
               T+L  VAAHEIGH+LGL HS +  ALM    H    L  ++ LSQD++ G+  LYG
Sbjct: 199 GVWLTDLVHVAAHEIGHALGLMHSQHGRALM----HLNATLRGWKALSQDELWGLHRLYG 254


>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
           sapiens]
          Length = 183

 Score = 85.5 bits (210), Expect = 1e-16
 Identities = 53/145 (36%), Positives = 77/145 (53%), Gaps = 4/145 (2%)

Query: 37  YLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPD 96
           YL  Y  L+K ++     K    + + +R  Q+   L V+G+LD  T   MR+PRCG+ D
Sbjct: 31  YLSQYGYLQKPLEGSNNFKPED-ITEALRAFQEASELPVSGQLDDATRARMRQPRCGLED 89

Query: 97  VGHFRTFPGI--PKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYE 154
             + +T   +   +WRK HLT+RI+N    LP     +A+ +A + W  V PLTF  +  
Sbjct: 90  PFNQKTLKYLLLGRWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQA 149

Query: 155 GEADIMISFAVREHG-DFYPFDGPG 178
           G ADI +SF  R+       FDGPG
Sbjct: 150 GAADIRLSFHGRQSSYCSNTFDGPG 174


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.139    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,262,053
Number of Sequences: 37866
Number of extensions: 1086261
Number of successful extensions: 6717
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 5858
Number of HSP's gapped (non-prelim): 616
length of query: 477
length of database: 18,247,518
effective HSP length: 106
effective length of query: 371
effective length of database: 14,233,722
effective search space: 5280710862
effective search space used: 5280710862
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.