Guide to the Human Genome
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Search of human proteins with 4505215

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein
[Homo sapiens]
         (469 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   989   0.0  
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      855   0.0  
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    561   e-160
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    526   e-149
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   502   e-142
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   458   e-129
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   454   e-128
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                450   e-126
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   407   e-113
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]   298   5e-81
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...   290   2e-78
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   274   1e-73
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]   272   4e-73
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...   248   1e-65
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...   239   4e-63
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    236   3e-62
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]      218   1e-56
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...   218   1e-56
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   212   5e-55
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   210   2e-54
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...   207   2e-53
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...   201   1e-51
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]   174   2e-43
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...   172   4e-43
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]          140   2e-33
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...   128   1e-29
gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]          113   4e-25
gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]          113   4e-25
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]      107   2e-23
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ...    87   4e-17

>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  989 bits (2556), Expect = 0.0
 Identities = 469/469 (100%), Positives = 469/469 (100%)

Query: 1   MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV 60
           MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
Sbjct: 1   MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV 60

Query: 61  VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN 120
           VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
Sbjct: 61  VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN 120

Query: 121 YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN 180
           YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
Sbjct: 121 YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN 180

Query: 181 LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY 240
           LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
Sbjct: 181 LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY 240

Query: 241 TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR 300
           TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
Sbjct: 241 TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR 300

Query: 301 FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY 360
           FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
Sbjct: 301 FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY 360

Query: 361 PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP 420
           PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
Sbjct: 361 PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP 420

Query: 421 GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 469
           GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Sbjct: 421 GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 469


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  855 bits (2210), Expect = 0.0
 Identities = 403/403 (100%), Positives = 403/403 (100%)

Query: 67  MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 126
           MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP
Sbjct: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60

Query: 127 RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 186
           RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ
Sbjct: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120

Query: 187 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV 246
           PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV
Sbjct: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV 180

Query: 247 QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN 306
           QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN
Sbjct: 181 QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN 240

Query: 307 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS 366
           PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS
Sbjct: 241 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS 300

Query: 367 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV 426
           SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV
Sbjct: 301 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV 360

Query: 427 DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 469
           DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Sbjct: 361 DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 403


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  561 bits (1445), Expect = e-160
 Identities = 267/461 (57%), Positives = 342/461 (74%), Gaps = 7/461 (1%)

Query: 9   LLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQ 68
           LLL    +S +FP +  ++E++   VQ YLEK+Y L ++  Q  ++  +  +VEKLK+MQ
Sbjct: 10  LLLLHVQISKAFPVS--SKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQ 67

Query: 69  EFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRA 128
            FFGL VTGKP+ ETL +MK+PRCGVPD   F+LT GNP+WE+T+LTYRI NYTP L  A
Sbjct: 68  RFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEA 127

Query: 129 DVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPG 188
           +V+ AI+ AF+LWS  +PL FT++S+G+ADI I+F + DH DNSPFDGP G LAHAFQPG
Sbjct: 128 EVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPG 187

Query: 189 PGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SGDV 246
            GIGGDAHFD +E WTN    YNL  VAAHE GHSLGL+HS+D GALMYP+Y F  + + 
Sbjct: 188 QGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNY 247

Query: 247 QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN 306
            L QDDIDGIQAIYG S NP+QP GP TPK CD  LTFDAITT+RGE++FFKDR++ R +
Sbjct: 248 SLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRH 307

Query: 307 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS 366
           P    VE+NFIS+FWP LP G++AAYE  DRD +  FKGN+YWA+ G ++L GYPKDI S
Sbjct: 308 PQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDI-S 366

Query: 367 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV 426
           ++GFP +V+ IDAA+   +  KTYFFV +++WRYD  ++ M+PGYPK I+  FPGI  KV
Sbjct: 367 NYGFPSSVQAIDAAVFYRS--KTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKV 424

Query: 427 DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCR 467
           DAVF ++ FF+ F G R Y FD   +R+  + + N W NCR
Sbjct: 425 DAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCR 465


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  526 bits (1356), Expect = e-149
 Identities = 255/478 (53%), Positives = 340/478 (71%), Gaps = 13/478 (2%)

Query: 1   MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV 60
           M S P LLLL      ++        ++  ++LVQKYLE YY+LK D +Q  +R++SGPV
Sbjct: 1   MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60

Query: 61  VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN 120
           V+K+++MQ+F GL+VTGK D++TL+VM++PRCGVPDV  F    G P+W +THLTYRI N
Sbjct: 61  VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN 120

Query: 121 YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN 180
           YTPDLP+  VD A+EKA ++W  VTPLTF+++ EG+ADIMISF   +H D  PFDGPG  
Sbjct: 121 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV 180

Query: 181 LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY 240
           LAHA+ PGPGI GDAHFD+DE+WT +    NL  VAAHE+GHSLGL HS +  ALMYP Y
Sbjct: 181 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 240

Query: 241 TFSGDV---QLAQDDIDGIQAIYGRSQN-------PVQPIGPQ--TPKACDSKLTFDAIT 288
               D+   +L+QDDI+GIQ++YG   +       P +P+ P+  TP  CD  L+FDA++
Sbjct: 241 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS 300

Query: 289 TIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKY 348
           T+RGE++ FKDR + R +    E EL+ IS FWP LP+G++AAYE   +D V  FKGN++
Sbjct: 301 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF 360

Query: 349 WAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMD 408
           WA++G  V  GYP+ I+ + GFP TV+ IDAA+S++   KTYFFV +KYWR+DE + SM+
Sbjct: 361 WAIRGNEVRAGYPRGIH-TLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSME 419

Query: 409 PGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 466
           PG+PK IA DFPGI  K+DAVF + GFFYFF G+ Q +FDP  K++    K+NSW NC
Sbjct: 420 PGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  502 bits (1293), Expect = e-142
 Identities = 246/472 (52%), Positives = 334/472 (70%), Gaps = 16/472 (3%)

Query: 9   LLLFWGVVSHSFPATLETQEQDV--DLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQ 66
           L+L    V  ++P +   +E+D   DL Q+YLEKYYNL+ D +Q  +R++S  +V+K++ 
Sbjct: 7   LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQF-RRKDSNLIVKKIQG 65

Query: 67  MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 126
           MQ+F GL+VTGK D +TL+VM++PRCGVPDV  F    G P+W +THLTYRI NYTPDLP
Sbjct: 66  MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLP 125

Query: 127 RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 186
           R  VD AIEKA ++W  VTPLTF+++ EG+ADIMISF   +H D   FDGPG +LAHA+ 
Sbjct: 126 RDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYP 185

Query: 187 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYP---SYTFS 243
           PGPG+ GD HFD+DE+WT +    NL  VAAHELGHSLGL HS +  ALMYP   S+T  
Sbjct: 186 PGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTEL 245

Query: 244 GDVQLAQDDIDGIQAIYG----RSQNPVQPI-----GPQTPKACDSKLTFDAITTIRGEV 294
              +L+QDD++GIQ++YG     ++ P+ P      G + P  CD  L+FDAI+T+RGE 
Sbjct: 246 AQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEY 305

Query: 295 MFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQ 354
           +FFKDR++ R + + PE E + IS FWP LP+ L+AAYE   RD V  FKGN++WA++G 
Sbjct: 306 LFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGN 365

Query: 355 NVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKM 414
            V  GYP+ I+ + GFP T++ IDAA+S++   KTYFF A+KYWR+DE  +SM+ G+P++
Sbjct: 366 EVQAGYPRGIH-TLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRL 424

Query: 415 IAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 466
           IA DFPG+  KVDAV    GFFYFF G+ Q++FDP  + +  + K+NSW +C
Sbjct: 425 IADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  458 bits (1178), Expect = e-129
 Identities = 221/444 (49%), Positives = 296/444 (66%), Gaps = 4/444 (0%)

Query: 25  ETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETL 84
           +  E+D+   ++YL  YY+  N    + K   +  + E+L++MQ FFGL+VTGK D  TL
Sbjct: 30  DLSEEDLQFAERYLRSYYHPTNLAG-ILKENAASSMTERLREMQSFFGLEVTGKLDDNTL 88

Query: 85  KVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNV 144
            VMK+PRCGVPDV ++ +     +W + +LTYRI NYTPD+  ++V+ A +KAF++WS+V
Sbjct: 89  DVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDV 148

Query: 145 TPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT 204
           TPL FT++ +G ADIMISF   +H D  PFDGP G LAHAF PGP  GGDAHFD+DE WT
Sbjct: 149 TPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWT 208

Query: 205 NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG--DVQLAQDDIDGIQAIYGR 262
           ++ + YNL  VAAHE GHSLGL HS D GALM+P YT++G     L  DD+ GIQ++YG 
Sbjct: 209 SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 268

Query: 263 SQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWP 322
                 P  P+TP  CD  L+ DAIT++RGE M FKDRF+ R +P   + EL     FWP
Sbjct: 269 GDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWP 328

Query: 323 QLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALS 382
           +LPN ++AAYE    D +  F+G K+WA+ G ++L GYPK I S  G P+ VK I AA+ 
Sbjct: 329 ELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKI-SELGLPKEVKKISAAVH 387

Query: 383 EENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGT 442
            E+TGKT  F  N+ WRYD+    MD  YP++I  DFPGIG KVDAV+ K+G+ YFF+G 
Sbjct: 388 FEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGP 447

Query: 443 RQYKFDPKTKRILTLQKANSWFNC 466
            Q+++   + RI+ +  ANS   C
Sbjct: 448 IQFEYSIWSNRIVRVMPANSILWC 471


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  454 bits (1168), Expect = e-128
 Identities = 231/468 (49%), Positives = 306/468 (65%), Gaps = 9/468 (1%)

Query: 7   LLLLLFWGVVSHSFPATLET--QEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVV-EK 63
           LL+LL     S + P    T  ++ +V   ++YLEK+Y L+ +   V K + SG ++ EK
Sbjct: 4   LLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEK 63

Query: 64  LKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTP 123
           +++MQ F GLKVTG+ D  TL++M  PRCGVPDV  F    G P W + ++TYRI NYTP
Sbjct: 64  IQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTP 123

Query: 124 DLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAH 183
           D+ R DVD+AI KAFQ+WSNVTPL F+K++ G ADI++ F RG H D   FDG GG LAH
Sbjct: 124 DMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAH 183

Query: 184 AFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF- 242
           AF PG GIGGDAHFDEDE WT +    NL   A HE+GHSLGL HS+D  A+M+P+Y + 
Sbjct: 184 AFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYV 243

Query: 243 -SGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQT--PKACDSKLTFDAITTIRGEVMFFKD 299
                +L+ DDI GIQ++YG  +   +   P    P  CD  L+FDA+TT+  ++ FFKD
Sbjct: 244 DINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKD 303

Query: 300 RFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHG 359
           RF+       P+  +N IS  WP LP+G+EAAYE   R++V  FK +KYW +        
Sbjct: 304 RFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPN 363

Query: 360 YPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDF 419
           YPK I+ SFGFP  VK IDAA+      +TYFFV N+YWRYDE ++ MDPGYPK+I  +F
Sbjct: 364 YPKSIH-SFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNF 422

Query: 420 PGIGHKVDAVF-MKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 466
            GIG K+DAVF  K+ ++YFF G+ Q+++D   +RI    K+NSWF C
Sbjct: 423 QGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC 470


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score =  450 bits (1157), Expect = e-126
 Identities = 233/467 (49%), Positives = 309/467 (66%), Gaps = 9/467 (1%)

Query: 7   LLLLLFWGVVSHSFPATLETQ-EQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLK 65
           LLL LF+   S +FP    T+ E+++ L Q YL ++Y+L+ +G  + + +N   + +K++
Sbjct: 5   LLLFLFFITFSSAFPLVRMTENEENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLIDDKIR 64

Query: 66  QMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDL 125
           +MQ FFGL VTGK D+ TL++MK PRCGVPDV Q+  T   P W + +LTYRI NYTPD+
Sbjct: 65  EMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTL--PGWRKYNLTYRIINYTPDM 122

Query: 126 PRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDH-RDNSPFDGPGGNLAHA 184
            RA VD AI++  ++WS VTPL FTK+S+G ADIMI+F    H R    FDGP G L HA
Sbjct: 123 ARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHA 182

Query: 185 FQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG 244
           F PGPG+GGD HFDEDE WT +   +NL  VAAHE GH+LGLSHS D  ALM+P+Y    
Sbjct: 183 FPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLD 242

Query: 245 DVQ--LAQDDIDGIQAIYGR-SQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRF 301
             +  L+QDDI+GIQ+IYG   + P +P  P  P ACD  LTFDAITT R EVMFFK R 
Sbjct: 243 PRKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRREVMFFKGRH 302

Query: 302 YMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYP 361
             R      +VE   I+ FWP LP  L+AAYE   RD++  FK   +W ++G  VL  YP
Sbjct: 303 LWRIYYDITDVEFELIASFWPSLPADLQAAYE-NPRDKILVFKDENFWMIRGYAVLPDYP 361

Query: 362 KDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPG 421
           K I++  GFP  VK IDAA+ ++ T KTYFFV    WR+DE  ++MD G+P+ +   FPG
Sbjct: 362 KSIHT-LGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPG 420

Query: 422 IGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRK 468
           I  +VDA F   GFF+F  G++Q+++D KTK I  + + N+WF C++
Sbjct: 421 ISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQCKE 467


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  407 bits (1045), Expect = e-113
 Identities = 207/458 (45%), Positives = 286/458 (62%), Gaps = 16/458 (3%)

Query: 22  ATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKR--RNSGPVVEKLKQMQEFFGLKVTGKP 79
           A+  T   +  L Q YL+KYY  K +G Q+ +   R S  ++ K+K++Q FFGL+VTGK 
Sbjct: 29  ASPRTWRNNYRLAQAYLDKYYTNK-EGHQIGEMVARGSNSMIRKIKELQAFFGLQVTGKL 87

Query: 80  DAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQ 139
           D  T+ V+K+PRCGVPDVA + L  G P+W++  LTYRI  YTP +   +VD A+E A Q
Sbjct: 88  DQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKNTLTYRISKYTPSMSSVEVDKAVEMALQ 147

Query: 140 LWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDE 199
            WS+  PL+F +++ G+ADIMISF  GDH D+ PFDGP G LAHAF PG G+GGD HFD 
Sbjct: 148 AWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDN 207

Query: 200 DERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG--DVQLAQDDIDGIQ 257
            E+WT     +NL  VAAHE GH+LGL+HSTD  ALMYP+Y +       L +DD+ GIQ
Sbjct: 208 AEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQ 267

Query: 258 AIYGRSQ----NPVQPIG----PQTPKACDSKLTFDAITTIRGEVMFFKDR-FYMRTNPF 308
           A+YG  +     P  P      P  P  CDS  +FDA+T +  E++ FKDR F+ R    
Sbjct: 268 ALYGPRKVFLGKPTLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLLFKDRIFWRRQVHL 327

Query: 309 YPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSF 368
              +  + I+  +PQL + ++AAYE A+R    FFKG  YW  +G   + G P+ IY  F
Sbjct: 328 RTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQ-MQGPPRTIY-DF 385

Query: 369 GFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDA 428
           GFPR V+ IDAA+      KT FFV ++Y+ YDE KR M+  YPK    +F G+  ++DA
Sbjct: 386 GFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQIDA 445

Query: 429 VFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 466
               +G+ YFF G + YK+D + + ++++ K++SW  C
Sbjct: 446 AVELNGYIYFFSGPKTYKYDTEKEDVVSVVKSSSWIGC 483


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score =  298 bits (764), Expect = 5e-81
 Identities = 190/473 (40%), Positives = 242/473 (51%), Gaps = 65/473 (13%)

Query: 35  QKYLEKY-YNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCG 93
           Q +L+ Y Y L  D R      ++  +   +  MQ+F+G+ VTG  D  T++ MK+PRCG
Sbjct: 82  QNWLKSYGYLLPYDSR-ASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCG 140

Query: 94  VPDVAQFVLTEGNPR-------WEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTP 146
           VPD         N R       W Q H+TY I NYTP +   D   AI +AF +W  VTP
Sbjct: 141 VPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTP 200

Query: 147 LTFTKV-------SEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDE 199
           LTF +V          +ADIMI F  G H D+SPFDG GG LAHA+ PGPGIGGD HFD 
Sbjct: 201 LTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDS 260

Query: 200 DERWT---NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SGDVQLAQDDID 254
           DE WT    N    +L  VA HELGH+LGL HS+D  A+M P Y +  + + +L QDD+ 
Sbjct: 261 DEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQ 320

Query: 255 GIQAIYGRSQNPVQPIGP------------------------------------QTPKAC 278
           GIQ IYG    P++P  P                                      P  C
Sbjct: 321 GIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNIC 380

Query: 279 DSKLTFDAITTIRGEVMFFKDRFYMR-TNPFYPEVELNFISVFWPQLPNGLEAAYEFADR 337
           D    F+ +   RGE+  FKDR++ R  N    E     I  FW  LP  ++AAYE AD 
Sbjct: 381 DG--NFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADG 438

Query: 338 DEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKY 397
             V FFKG+KYW  +   V  GYP  +    G     + ID AL  E  GKTYFF   +Y
Sbjct: 439 RFV-FFKGDKYWVFKEVTVEPGYPHSL-GELGSCLPREGIDTALRWEPVGKTYFFKGERY 496

Query: 398 WRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFM-KDGFF-YFFHGTRQYKFD 448
           WRY E +R+ DPGYPK I   + GI       F+ K+G++ YF+ G   +KFD
Sbjct: 497 WRYSEERRATDPGYPKPIT-VWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFD 548


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score =  290 bits (742), Expect = 2e-78
 Identities = 180/483 (37%), Positives = 253/483 (52%), Gaps = 70/483 (14%)

Query: 34  VQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCG 93
           V+ +L+KY  L     ++   R++  +   L  MQ+F+G+ +TGK D  T+  MK+PRCG
Sbjct: 43  VEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102

Query: 94  VPDVAQ-----------FVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWS 142
           VPD  +           + LT    +W+  H+TY I+N TP +   +   AI +AF +W 
Sbjct: 103 VPDQTRGSSKFHIRRKRYALT--GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQ 160

Query: 143 NVTPLTFTKVSEGQ-------ADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDA 195
           NVTPLTF +V   +        DI I F  G H D+SPFDG GG LAHA+ PGPGIGGD 
Sbjct: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220

Query: 196 HFDEDERWT---NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SGDVQLAQ 250
           HFD DE WT    N    +L  VA HELGH+LGL HS D  A+M P Y +  + + +L  
Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280

Query: 251 DDIDGIQAIYG--------------------------RSQNPVQPIGPQT---------P 275
           DD+ GIQ IYG                          R  +  +P  P T         P
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340

Query: 276 KACDSKLTFDAITTIRGEVMFFKDRFY--MRTNPFYPEVELNFISVFWPQLPNGLEAAYE 333
             CD    F+ +  +R E+  FKD+++  +R N       +  I+ FW  LP  ++A YE
Sbjct: 341 NICDG--NFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQ-ITYFWRGLPPSIDAVYE 397

Query: 334 FADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFV 393
            +D + V FFKGNKYW  +   +  GYP D+  + G       ID+A+  E+ GKTYFF 
Sbjct: 398 NSDGNFV-FFKGNKYWVFKDTTLQPGYPHDLI-TLGSGIPPHGIDSAIWWEDVGKTYFFK 455

Query: 394 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFM--KDGFFYFFHGTRQYKFDPKT 451
            ++YWRY E  ++MDPGYPK I   + GI       F+  ++GF YF+ G   +KF+ + 
Sbjct: 456 GDRYWRYSEEMKTMDPGYPKPIT-VWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQI 514

Query: 452 KRI 454
            ++
Sbjct: 515 LKV 517


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  274 bits (701), Expect = 1e-73
 Identities = 179/500 (35%), Positives = 250/500 (50%), Gaps = 89/500 (17%)

Query: 35  QKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGV 94
           + +L  Y  L    R +   R++  +   L +MQ F+G+ VTG  D ET + MK+PRCGV
Sbjct: 54  ENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGV 113

Query: 95  PDVAQF-VLTEGNPR------------WEQTHLTYRIENYTPDLPRADVDHAIEKAFQLW 141
           PD  QF V  + N R            W   HLT+ I+NYT  L       A+ +AF++W
Sbjct: 114 PD--QFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVW 171

Query: 142 SNVTPLTFTKVS--------EGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGG 193
              TPL F +V         + +ADIM+ F  G H D+SPFDG GG LAHA+ PGPG+GG
Sbjct: 172 EQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGG 231

Query: 194 DAHFDEDERWT---NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFS--GDVQL 248
           D HFD DE WT    +    NL  VA HELGH+LGL HS++  A+M P Y +    + +L
Sbjct: 232 DTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKL 291

Query: 249 AQDDIDGIQAIYG-----------------------------------------RSQNPV 267
            +DD+ GIQ +YG                                         R   P 
Sbjct: 292 PEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPG 351

Query: 268 QPIGPQT--------PKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNF--- 316
            P+ P+         P  CD    FD +  +RGE+  FK R++ R    +  V  N+   
Sbjct: 352 PPVQPRATERPDQYGPNICDG--DFDTVAMLRGEMFVFKGRWFWRVR--HNRVLDNYPMP 407

Query: 317 ISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKH 376
           I  FW  LP  + AAYE  D   V FFKG++YW  +  N+  GYP+ + +S+G       
Sbjct: 408 IGHFWRGLPGDISAAYERQDGRFV-FFKGDRYWLFREANLEPGYPQPL-TSYGLGIPYDR 465

Query: 377 IDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKD--G 434
           ID A+  E TG T+FF  ++YWR++E  +  DPGYPK I+  + GI       F+ +   
Sbjct: 466 IDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPIS-VWQGIPASPKGAFLSNDAA 524

Query: 435 FFYFFHGTRQYKFDPKTKRI 454
           + YF+ GT+ +KFD +  R+
Sbjct: 525 YTYFYKGTKYWKFDNERLRM 544


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score =  272 bits (696), Expect = 4e-73
 Identities = 183/497 (36%), Positives = 253/497 (50%), Gaps = 57/497 (11%)

Query: 5   PPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKL 64
           PP  LLL    +  +  A+L + +      + +L++Y  L     +   +R+   +   +
Sbjct: 7   PPRCLLLPLLTLGTAL-ASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAI 65

Query: 65  KQMQEFFGLKVTGKPDAETLKVMKQPRCGVPD---------VAQFVLTEGNPRWEQTHLT 115
             MQ+F+GL+VTGK DA+T+K M++PRCGVPD         V +        +W+   +T
Sbjct: 66  AAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEIT 125

Query: 116 YRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVS--------EGQADIMISFVRGD 167
           + I+NYTP +       AI KAF++W + TPL F +V         E QADIMI F  G 
Sbjct: 126 FCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGF 185

Query: 168 HRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYN---LHRVAAHELGHSL 224
           H D++PFDG GG LAHA+ PGP IGGD HFD  E WT    + N   +  VA HELGH+L
Sbjct: 186 HGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHAL 245

Query: 225 GLSHSTDIGALMYPSYTF--SGDVQLAQDDIDGIQAIYG-----------------RSQN 265
           GL HS+D  A+M P Y +  + +  L  DD  GIQ +YG                 R   
Sbjct: 246 GLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSV 305

Query: 266 PVQPIGP-QTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN-----PFYPEVELNFISV 319
           P +P  P   P  CD    FD +  +RGE+  FK+R++ R         YP      I  
Sbjct: 306 PDKPKNPTYGPNICDG--NFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMP----IGQ 359

Query: 320 FWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDA 379
           FW  LP  +  AYE  D   V FFKG+K+W     ++  GYPK I    G       IDA
Sbjct: 360 FWRGLPASINTAYERKDGKFV-FFKGDKHWVFDEASLEPGYPKHI-KELGRGLPTDKIDA 417

Query: 380 ALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFM--KDGFFY 437
           AL     GKTYFF  NKY+R++E  R++D  YPK I   + GI       FM   + F Y
Sbjct: 418 ALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEGIPESPRGSFMGSDEVFTY 476

Query: 438 FFHGTRQYKFDPKTKRI 454
           F+ G + +KF+ +  ++
Sbjct: 477 FYKGNKYWKFNNQKLKV 493


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score =  248 bits (632), Expect = 1e-65
 Identities = 159/399 (39%), Positives = 215/399 (53%), Gaps = 49/399 (12%)

Query: 87  MKQPRCGVPDVA----------QFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEK 136
           ++ PRCGVPD +          +FVL+ G  RWE+T LTYRI  +   L +  V   + +
Sbjct: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGG--RWEKTDLTYRILRFPWQLVQEQVRQTMAE 132

Query: 137 AFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAH 196
           A ++WS+VTPLTFT+V EG+ADIMI F R  H D+ PFDGPGG LAHAF P     GD H
Sbjct: 133 ALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVH 192

Query: 197 FDEDERWT-NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDG 255
           FD DE WT  + +  +L +VAAHE GH LGL H+T   ALM   YTF   + L+ DD  G
Sbjct: 193 FDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRG 252

Query: 256 IQAIYGR------------------SQNPVQPIGPQT-PKACDSKLTFDAITTIRGEVMF 296
           +Q +YG+                    N + P+ P   P AC++  +FDA++TIRGE+ F
Sbjct: 253 VQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEA--SFDAVSTIRGELFF 310

Query: 297 FKDRFYMR-----TNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAV 351
           FK  F  R       P YP +     S  W  LP+ ++AA+E A +  + FF+G +YW  
Sbjct: 311 FKAGFVWRLRGGQLQPGYPAL----ASRHWQGLPSPVDAAFEDA-QGHIWFFQGAQYWVY 365

Query: 352 QGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGY 411
            G+  + G P  + +  G  R   H       E   K YFF    YWR+    R +D   
Sbjct: 366 DGEKPVLG-PAPL-TELGLVRFPVHAALVWGPEK-NKIYFFRGRDYWRFHPSTRRVDSPV 422

Query: 412 PKMIAHDFPGIGHKVDAVFM-KDGFFYFFHGTRQYKFDP 449
           P+  A D+ G+  ++DA F   DG+ YF  G   +KFDP
Sbjct: 423 PRR-ATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score =  239 bits (610), Expect = 4e-63
 Identities = 167/485 (34%), Positives = 237/485 (48%), Gaps = 52/485 (10%)

Query: 6   PLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLK 65
           PLLLLL  G            + +D+ L  ++L ++  L        + +    + + + 
Sbjct: 24  PLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAIT 83

Query: 66  QMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPR--------WEQTHLTYR 117
            MQ+F GL+ TG  D  TL +MK PRC +PD+   VLT+   R        W + +L++R
Sbjct: 84  AMQQFGGLEATGILDEATLALMKTPRCSLPDLP--VLTQARRRRQAPAPTKWNKRNLSWR 141

Query: 118 IENYTPDLPRAD--VDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFD 175
           +  +  D P     V   +  A ++WS++ PL F +V+   ADI I F + DH D  PFD
Sbjct: 142 VRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFD 201

Query: 176 GPGGNLAHAFQPG-PGIGGDAHFDEDERWTNNFREYNLH-----RVAAHELGHSLGLSHS 229
           GPGG +AHAF PG     GD HFD+DE WT  FR  + H      VA HE GH++GLSH 
Sbjct: 202 GPGGTVAHAFFPGHHHTAGDTHFDDDEAWT--FRSSDAHGMDLFAVAVHEFGHAIGLSHV 259

Query: 230 TDIGALMYPSYTFS-GD---VQLAQDDIDGIQAIYG-------RSQNPVQPIGPQTPKAC 278
               ++M P Y    GD     L  +D   +  +YG        +Q    P+ P+ P   
Sbjct: 260 AAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNR 319

Query: 279 DS-----------KLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISV--FWPQLP 325
            S              FDA+  IRGE  FFK +++ R       V L    +  FW  LP
Sbjct: 320 SSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLP 379

Query: 326 ---NGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALS 382
              + ++A YE     ++ FFKG++YW  +  NV  GYP+ + S F  P     IDAA S
Sbjct: 380 LHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPV-SDFSLP--PGGIDAAFS 436

Query: 383 EENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV-DAVFMKDGFFYFFHG 441
             +  +TYFF    YWRYD++ R MDPGYP   +  + G+   + DA+   DG  YFF G
Sbjct: 437 WAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGASYFFRG 495

Query: 442 TRQYK 446
              +K
Sbjct: 496 QEYWK 500


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  236 bits (602), Expect = 3e-62
 Identities = 118/235 (50%), Positives = 156/235 (66%), Gaps = 11/235 (4%)

Query: 35  QKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGV 94
           Q YL+++Y   ++       +N+  +  KLK+MQ+FFGL +TG  ++  +++M++PRCGV
Sbjct: 36  QDYLKRFYLYDSE------TKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGV 89

Query: 95  PDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSE 154
           PDVA++ L   +P+W    +TYRI +YT DLP   VD  + KA  +W    PL F KV  
Sbjct: 90  PDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVW 149

Query: 155 GQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTN-NFREYNLH 213
           G ADIMI F RG H D+ PFDGPG  LAHAF PG G+GGDAHFDEDERWT+ +    N  
Sbjct: 150 GTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFL 209

Query: 214 RVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQ---LAQDDIDGIQAIYGRSQN 265
             A HELGHSLG+ HS+D  A+MYP+Y  +GD Q   L+QDDI GIQ +YG+  N
Sbjct: 210 YAATHELGHSLGMGHSSDPNAVMYPTYG-NGDPQNFKLSQDDIKGIQKLYGKRSN 263


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score =  218 bits (554), Expect = 1e-56
 Identities = 115/285 (40%), Positives = 162/285 (56%), Gaps = 16/285 (5%)

Query: 195 AHFDEDERWTNNF---REYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQD 251
           A++D+D +W   F   + Y+L  VAAHE GH++GL HS D GALM P YT++ + +L+QD
Sbjct: 329 ANYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQD 386

Query: 252 DIDGIQAIYGRSQN------PVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRT 305
           DI GIQ +YG S +      P   +GP TP+ C   + FD I  IRGE+ FFKDRF  RT
Sbjct: 387 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 446

Query: 306 -NPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDI 364
             P    +    ++ FWP+LP  ++A YE    ++  FF GN+YW      +  GYPK +
Sbjct: 447 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 506

Query: 365 YSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGH 424
            +S G P  V+ +DAA +     KTY F  +K+WRY+E K+ MDPG+PK+IA  +  I  
Sbjct: 507 -TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPD 565

Query: 425 KVDAV--FMKDGFFYFFHGTRQYKFDPKTKRILTLQKANS-WFNC 466
            +DAV      G  YFF G    K + ++ + +      S W  C
Sbjct: 566 NLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 610



 Score =  174 bits (442), Expect = 1e-43
 Identities = 78/143 (54%), Positives = 103/143 (72%)

Query: 62  EKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENY 121
           + LK+MQ+FFGL  TG  D  T++ M++PRCG PDVA +      P+W++  +TYRI  Y
Sbjct: 22  DTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGY 81

Query: 122 TPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNL 181
           TPDL    VD A  +AFQ+WS+VTPL F+++ +G+ADIMI+F R +H D  PFDG  G L
Sbjct: 82  TPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLL 141

Query: 182 AHAFQPGPGIGGDAHFDEDERWT 204
           AHAF PG G+GGD+HFD+DE WT
Sbjct: 142 AHAFAPGTGVGGDSHFDDDELWT 164


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score =  218 bits (554), Expect = 1e-56
 Identities = 115/285 (40%), Positives = 162/285 (56%), Gaps = 16/285 (5%)

Query: 195 AHFDEDERWTNNF---REYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQD 251
           A++D+D +W   F   + Y+L  VAAHE GH++GL HS D GALM P YT++ + +L+QD
Sbjct: 379 ANYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQD 436

Query: 252 DIDGIQAIYGRSQN------PVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRT 305
           DI GIQ +YG S +      P   +GP TP+ C   + FD I  IRGE+ FFKDRF  RT
Sbjct: 437 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 496

Query: 306 -NPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDI 364
             P    +    ++ FWP+LP  ++A YE    ++  FF GN+YW      +  GYPK +
Sbjct: 497 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 556

Query: 365 YSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGH 424
            +S G P  V+ +DAA +     KTY F  +K+WRY+E K+ MDPG+PK+IA  +  I  
Sbjct: 557 -TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPD 615

Query: 425 KVDAV--FMKDGFFYFFHGTRQYKFDPKTKRILTLQKANS-WFNC 466
            +DAV      G  YFF G    K + ++ + +      S W  C
Sbjct: 616 NLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 660



 Score =  177 bits (449), Expect = 2e-44
 Identities = 84/175 (48%), Positives = 114/175 (65%), Gaps = 6/175 (3%)

Query: 30  DVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQ 89
           D +L  +YL  +Y    +        N   + + LK+MQ+FFGL  TG  D  T++ M++
Sbjct: 46  DKELAVQYLNTFYGCPKESC------NLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRK 99

Query: 90  PRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTF 149
           PRCG PDVA +      P+W++  +TYRI  YTPDL    VD A  +AFQ+WS+VTPL F
Sbjct: 100 PRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRF 159

Query: 150 TKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT 204
           +++ +G+ADIMI+F R +H D  PFDG  G LAHAF PG G+GGD+HFD+DE WT
Sbjct: 160 SRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 214


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  212 bits (540), Expect = 5e-55
 Identities = 137/371 (36%), Positives = 189/371 (50%), Gaps = 66/371 (17%)

Query: 34  VQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCG 93
           V+ +L+KY  L     ++   R++  +   L  MQ+F+G+ +TGK D  T+  MK+PRCG
Sbjct: 43  VEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102

Query: 94  VPDVAQ-----------FVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWS 142
           VPD  +           + LT    +W+  H+TY I+N TP +   +   AI +AF +W 
Sbjct: 103 VPDQTRGSSKFHIRRKRYALT--GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQ 160

Query: 143 NVTPLTFTKVSEGQ-------ADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDA 195
           NVTPLTF +V   +        DI I F  G H D+SPFDG GG LAHA+ PGPGIGGD 
Sbjct: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220

Query: 196 HFDEDERWT---NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SGDVQLAQ 250
           HFD DE WT    N    +L  VA HELGH+LGL HS D  A+M P Y +  + + +L  
Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280

Query: 251 DDIDGIQAIYG--------------------------RSQNPVQPIGPQT---------P 275
           DD+ GIQ IYG                          R  +  +P  P T         P
Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340

Query: 276 KACDSKLTFDAITTIRGEVMFFKDRFY--MRTNPFYPEVELNFISVFWPQLPNGLEAAYE 333
             CD    F+ +  +R E+  FKD+++  +R N       +  I+ FW  LP  ++A YE
Sbjct: 341 NICDG--NFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQ-ITYFWRGLPPSIDAVYE 397

Query: 334 FADRDEVRFFK 344
            +D + V FFK
Sbjct: 398 NSDGNFV-FFK 407



 Score = 29.3 bits (64), Expect = 8.0
 Identities = 19/51 (37%), Positives = 26/51 (50%), Gaps = 3/51 (5%)

Query: 390 YFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVF-MKDGFFYFF 439
           + F    +WR     R MD GYP  I + + G+   +DAV+   DG F FF
Sbjct: 358 FVFKDQWFWRVRN-NRVMD-GYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  210 bits (535), Expect = 2e-54
 Identities = 160/461 (34%), Positives = 225/461 (48%), Gaps = 48/461 (10%)

Query: 37  YLEKYYNLKNDGRQVEKRRNSGP--VVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGV 94
           YL +Y  L+   + +E   N  P  + E L+  QE   L V+G+ D  T   M+QPRCG+
Sbjct: 31  YLSQYGYLQ---KPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGL 87

Query: 95  PD-----VAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTF 149
            D       +++L     RW + HLT+RI N    LP      A+ +AFQ WSNV PLTF
Sbjct: 88  EDPFNQKTLKYLLLG---RWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTF 144

Query: 150 TKVSEGQADIMISF-VRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT-NNF 207
            +V  G ADI +SF  R     ++ FDGPG  LAHA  P     G  HFDEDE WT   +
Sbjct: 145 QEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHADIPEL---GSVHFDEDEFWTEGTY 201

Query: 208 REYNLHRVAAHELGHSLGLSHSTDIGALMYPSYT-FSGDVQLAQDDIDGIQAIYGR---- 262
           R  NL  +AAHE+GH+LGL HS    ALM P Y  +    +L  DD+ GIQA+YG+    
Sbjct: 202 RGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPHFKLHPDDVAGIQALYGKKSPV 261

Query: 263 --------SQNPVQPIGPQTPK----ACDSKLTFDAITT-IRGEVMFFKDRFYMRTNPFY 309
                   ++ P  P  P  P      C S+L  DA+    RG+   FK  +    +   
Sbjct: 262 IRDEEEEETELPTVPPVPTEPSPMPDPCSSEL--DAMMLGPRGKTYAFKGDYVWTVSDSG 319

Query: 310 PEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFG 369
           P   L  +S  W  LP  L+AA        + FFKG+K W      +  G+PK +     
Sbjct: 320 PG-PLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKL----- 373

Query: 370 FPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAV 429
             R   ++DAAL      K + F  + YW++DE  R+    YPK I   F G+ ++  A 
Sbjct: 374 -NRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAA 432

Query: 430 F-MKDGFFYFFHGTRQYKFDP--KTKRILTLQKANSWFNCR 467
              +DG  YFF G   ++ +   + ++      +++W +CR
Sbjct: 433 MSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCR 473


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score =  207 bits (527), Expect = 2e-53
 Identities = 157/487 (32%), Positives = 223/487 (45%), Gaps = 54/487 (11%)

Query: 29  QDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMK 88
           QDV L   +L +Y  L        + ++   + + +K MQ F GL  TG+ D  T+  M+
Sbjct: 27  QDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMR 86

Query: 89  QPRCGVPDVAQFVLTEGNPR--------WEQTHLTYRIENY--TPDLPRADVDHAIEKAF 138
           +PRC +PDV          R        W++  LT+R+ ++  +  L +  V   +  A 
Sbjct: 87  KPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYAL 146

Query: 139 QLWSNVTPLTFTKVSEGQA---DIMISFVRGDHRDNSPFDGPGGNLAHAFQPGP-GIGGD 194
             W   + LTF +V   Q    DI+I F R  H+D+ PFDG GG LAHAF PG   I GD
Sbjct: 147 MAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGD 206

Query: 195 AHFDEDERWTNNFRE---YNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFS-GD---VQ 247
            HFD++E WT   ++    +L  VA HE GH+LGL HS+   ++M P Y    GD    +
Sbjct: 207 THFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYR 266

Query: 248 LAQDDIDGIQAIYGRSQN-------------PVQPIGPQT-------PKACDSKLTFDAI 287
           L+QDD DG+Q +YG++               P QP    T       P  C+    FDAI
Sbjct: 267 LSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEG--NFDAI 324

Query: 288 TTIRGEVMFFKDRFYMRTNPFYPEVELN--FISVFWPQLP---NGLEAAYEFADRDEVRF 342
             IRGE  FFK  ++ R  P    V      +  FW  LP     ++AAY       +  
Sbjct: 325 ANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILL 384

Query: 343 FKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDE 402
           F G ++W  Q +  L G  + + +  G P   + +DA  S    GKTY     +YWRYDE
Sbjct: 385 FSGPQFWVFQDRQ-LEGGARPL-TELGLP-PGEEVDAVFSWPQNGKTYLVRGRQYWRYDE 441

Query: 403 YKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDP---KTKRILTLQK 459
                DPGYP+ ++          D      G  YFF G   ++F     KT+       
Sbjct: 442 AAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPM 501

Query: 460 ANSWFNC 466
             +W +C
Sbjct: 502 GPNWLDC 508


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score =  201 bits (511), Expect = 1e-51
 Identities = 165/494 (33%), Positives = 233/494 (47%), Gaps = 69/494 (13%)

Query: 8   LLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQM 67
           L LL WG +    PA    QE   +  + +LEKY  L     QV K   S    + ++  
Sbjct: 12  LQLLLWGHLDAQ-PAERGGQELRKE-AEAFLEKYGYLNE---QVPKAPTSTRFSDAIRAF 66

Query: 68  QEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVL-----------------------TE 104
           Q    L V+G  D  TL+ M +PRCGV D   +                          +
Sbjct: 67  QWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQ 126

Query: 105 GNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKV-SEGQADIMISF 163
           GN +W + HL+YR+ N+   LP   V  A+  AFQLWSNV+ L F +  + G ADI ++F
Sbjct: 127 GN-KWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTF 185

Query: 164 VRGDHRD--NSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT-NNFREYNLHRVAAHEL 220
            +GDH D   + FDGPGG LAHAF P     G+AHFD+DERW+ +  R  NL  V AHE+
Sbjct: 186 FQGDHNDGLGNAFDGPGGALAHAFLPR---RGEAHFDQDERWSLSRRRGRNLFVVLAHEI 242

Query: 221 GHSLGLSHSTDIGALMYPSYTFSG-DVQLAQDDIDGIQAIYGR----------------- 262
           GH+LGL+HS    ALM P Y   G D  L+ DD+  +Q++YG+                 
Sbjct: 243 GHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTD 302

Query: 263 --SQNPVQPIG--PQT--PKACDSKLTFDAITTIRGEVMF-FKDRFYMRTNPFYPEVELN 315
             + +   P G  P+T  PK C S  +FDAIT  R + ++ FK   +          E  
Sbjct: 303 FETWDSYSPQGRRPETQGPKYCHS--SFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPR 360

Query: 316 FISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVK 375
            +   W  LP  +EAA    +  +  FFKG + W  +G   + G P+ +  + G PR   
Sbjct: 361 PLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQ-LCRAGGLPR--- 416

Query: 376 HIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMK-DG 434
           H DAAL      +   F   +Y+        ++P YP+ +  D+ GI  +V     + DG
Sbjct: 417 HPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSL-QDWGGIPEEVSGALPRPDG 475

Query: 435 FFYFFHGTRQYKFD 448
              FF   R ++ D
Sbjct: 476 SIIFFRDDRYWRLD 489


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score =  174 bits (440), Expect = 2e-43
 Identities = 90/185 (48%), Positives = 114/185 (61%), Gaps = 4/185 (2%)

Query: 20  FPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKP 79
           FP  L T   D  L ++YL +Y       R  E R  S  +   L  +Q+   L  TG+ 
Sbjct: 31  FPGDLRTNLTDRQLAEEYLYRY----GYTRVAEMRGESKSLGPALLLLQKQLSLPETGEL 86

Query: 80  DAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQ 139
           D+ TLK M+ PRCGVPD+ +F   EG+ +W   ++TY I+NY+ DLPRA +D A  +AF 
Sbjct: 87  DSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFA 146

Query: 140 LWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDE 199
           LWS VTPLTFT+V    ADI+I F   +H D  PFDG  G LAHAF PGPGI GDAHFD+
Sbjct: 147 LWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDD 206

Query: 200 DERWT 204
           DE W+
Sbjct: 207 DELWS 211



 Score =  100 bits (249), Expect = 3e-21
 Identities = 89/314 (28%), Positives = 129/314 (41%), Gaps = 81/314 (25%)

Query: 195 AHFDEDERWTNNF---REYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQD 251
           ++FD D++W   F   + Y+L  VAAHE GH+LGL HS+   ALMYP Y F+    L +D
Sbjct: 377 SNFDSDKKW--GFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKD 434

Query: 252 DIDGIQAIYGRSQNP-----------------VQPIGPQT-------------------- 274
           D++GI+ +YG    P                 V P GP T                    
Sbjct: 435 DVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPT 494

Query: 275 --PKACDSKLT---------------FDAITTIRGEVMFFKDRFYMR------TNPFYPE 311
             P A  S  T               FDAI  I  ++  FKD  Y R      + P  P 
Sbjct: 495 GPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPF 554

Query: 312 VELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFP 371
           +    I+  WP LP  L++ +E     ++ FF G + W   G +VL   P+ +    G  
Sbjct: 555 L----IADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLG--PRRL-DKLGLG 607

Query: 372 RTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGI--------G 423
             V  +  AL     GK   F   + WR+D   + +DP     +   FPG+         
Sbjct: 608 ADVAQVTGAL-RSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQ 666

Query: 424 HKVDAVFMKDGFFY 437
           ++  A F +D F++
Sbjct: 667 YREKAYFCQDRFYW 680


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  172 bits (437), Expect = 4e-43
 Identities = 93/232 (40%), Positives = 129/232 (55%), Gaps = 10/232 (4%)

Query: 32  DLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPR 91
           D V+ Y  +++  K +   + +        E   Q+ + F    T   D +   ++ QP 
Sbjct: 30  DFVEGYFHQFFLTKKESPLLTQ--------ETQTQLLQQFHRNGTDLLDMQMHALLHQPH 81

Query: 92  CGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTK 151
           CGVPD +   ++ G  +W +  LTYRI NY  D+  + V  +I  A  +WSNVTPL F +
Sbjct: 82  CGVPDGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQ 141

Query: 152 VSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYN 211
           V  G ADI +SF +  H D  PFDGPGG L HAF P  G  G  HFD++E W+ +   YN
Sbjct: 142 VQNGDADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASDTGYN 201

Query: 212 LHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG--DVQLAQDDIDGIQAIYG 261
           L  VA HE+GHSLGL HS +  ++MYP+Y +      QL+ DDI  IQ +YG
Sbjct: 202 LFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYG 253


>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 358

 Score =  140 bits (353), Expect = 2e-33
 Identities = 81/175 (46%), Positives = 98/175 (56%), Gaps = 45/175 (25%)

Query: 36  KYLEK-YYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGV 94
           KYLE  YYNLK++  Q+ ++R+S PV+EKLKQMQ FFGLK                    
Sbjct: 146 KYLENCYYNLKSEINQIGRQRDSSPVLEKLKQMQNFFGLKD------------------- 186

Query: 95  PDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSE 154
                                   +NY P+LP+ DVD A  KAF+LWSN + LTFT+  E
Sbjct: 187 ------------------------QNYMPNLPQEDVDRATGKAFELWSNASALTFTRDFE 222

Query: 155 GQADIMISFV-RGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFR 208
            + DI++SFV   D  DNSPF G  G LAHAF PGPGIGGD HFD DE  T +FR
Sbjct: 223 SEGDIILSFVFLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFR 277



 Score =  113 bits (282), Expect = 4e-25
 Identities = 54/92 (58%), Positives = 68/92 (73%), Gaps = 3/92 (3%)

Query: 336 DRDEVRF--FKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFV 393
           D DE R   F+ +K+W VQ   +L GYP+D+YSSF FP  VK IDAA+ E++TGKT+FFV
Sbjct: 267 DNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFV 326

Query: 394 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHK 425
           AN+YWRYDE  +S+D GYPK+I  D PGI  K
Sbjct: 327 ANEYWRYDENMQSVDAGYPKII-DDLPGISKK 357



 Score = 29.6 bits (65), Expect = 6.1
 Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 2/51 (3%)

Query: 316 FISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQG--QNVLHGYPKDI 364
           + S  +P+    ++AA    D  +  FF  N+YW      Q+V  GYPK I
Sbjct: 298 YSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPKII 348


>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score =  128 bits (321), Expect = 1e-29
 Identities = 126/453 (27%), Positives = 180/453 (39%), Gaps = 112/453 (24%)

Query: 60  VVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQ--------------FVLTEG 105
           + E +++ Q    L  +G+ DA TL  M +PRCGVPD+                   +  
Sbjct: 85  LAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRR 144

Query: 106 NPR---------WE--------------QTHLTYRI--ENYTPDLPRADVDHAIEKAFQL 140
           +PR         W+              +  L++R+  E  +  L  AD    +  AF++
Sbjct: 145 SPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRM 204

Query: 141 WSNVTPLTFTK--VSEGQA-DIMISFVRGDHRD-NSPFDGPGGNLAHAFQPGPGIGGDAH 196
           WS VTPL F +   + G A DI + F RG H      FDG G   AHA++ G     D H
Sbjct: 205 WSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIH 259

Query: 197 FDEDERWTNNFRE--YNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV-QLAQDDI 253
           FD+DE +T    +   +L +VA HE+GH LGL H+   G++M P+Y       +L   D 
Sbjct: 260 FDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDWSDR 319

Query: 254 DGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVE 313
             IQ +YG  +                   FD I   R +               Y EV 
Sbjct: 320 KAIQKLYGSCEGSFD-------------TAFDWIRKERNQ---------------YGEVM 351

Query: 314 LNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRT 373
           + F                         FF+ + YW  + +N    Y   I    G+P  
Sbjct: 352 VRF----------------------STYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGI 389

Query: 374 VKH-IDAALS--EENTGKTYFFVANKYWRYDEYK------RSMDPGYPKMIAHDFPGIGH 424
             H IDA +        + YFF  N+YWRYD  K            YPK+I+  FPGI  
Sbjct: 390 PTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPS 449

Query: 425 KVDAVF--MKDGFFYFFHGTRQYKFDPKTKRIL 455
            +D  F   +    YFF  +  + FD    R+L
Sbjct: 450 PLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVL 482


>gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score =  113 bits (282), Expect = 4e-25
 Identities = 57/105 (54%), Positives = 70/105 (66%), Gaps = 7/105 (6%)

Query: 105 GNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFV 164
           G  +W++       +NY P+LP+ DVD A  KAF+LWSN + LTFT+  E + DI++SFV
Sbjct: 19  GIQKWQED------QNYMPNLPQEDVDRATGKAFELWSNASALTFTRDFESEGDIILSFV 72

Query: 165 -RGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFR 208
              D  DNSPF G  G LAHAF PGPGIGGD HFD DE  T +FR
Sbjct: 73  FLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFR 117



 Score =  113 bits (282), Expect = 4e-25
 Identities = 54/92 (58%), Positives = 68/92 (73%), Gaps = 3/92 (3%)

Query: 336 DRDEVRF--FKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFV 393
           D DE R   F+ +K+W VQ   +L GYP+D+YSSF FP  VK IDAA+ E++TGKT+FFV
Sbjct: 107 DNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFV 166

Query: 394 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHK 425
           AN+YWRYDE  +S+D GYPK+I  D PGI  K
Sbjct: 167 ANEYWRYDENMQSVDAGYPKII-DDLPGISKK 197



 Score = 29.6 bits (65), Expect = 6.1
 Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 2/51 (3%)

Query: 316 FISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQG--QNVLHGYPKDI 364
           + S  +P+    ++AA    D  +  FF  N+YW      Q+V  GYPK I
Sbjct: 138 YSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPKII 188


>gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score =  113 bits (282), Expect = 4e-25
 Identities = 54/92 (58%), Positives = 68/92 (73%), Gaps = 3/92 (3%)

Query: 336 DRDEVRF--FKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFV 393
           D DE R   F+ +K+W VQ   +L GYP+D+YSSF FP  VK IDAA+ E++TGKT+FFV
Sbjct: 107 DNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFV 166

Query: 394 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHK 425
           AN+YWRYDE  +S+D GYPK+I  D PGI  K
Sbjct: 167 ANEYWRYDENMQSVDAGYPKII-DDLPGISKK 197



 Score =  110 bits (276), Expect = 2e-24
 Identities = 56/105 (53%), Positives = 69/105 (65%), Gaps = 7/105 (6%)

Query: 105 GNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFV 164
           G  +W++       +NY P+LP+ DVD A  KAF+LWS  + LTFT+  E + DI++SFV
Sbjct: 19  GIQKWQED------QNYMPNLPQEDVDRATGKAFELWSKASALTFTRDFESEGDIILSFV 72

Query: 165 -RGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFR 208
              D  DNSPF G  G LAHAF PGPGIGGD HFD DE  T +FR
Sbjct: 73  FLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFR 117



 Score = 29.6 bits (65), Expect = 6.1
 Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 2/51 (3%)

Query: 316 FISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQG--QNVLHGYPKDI 364
           + S  +P+    ++AA    D  +  FF  N+YW      Q+V  GYPK I
Sbjct: 138 YSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPKII 188


>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
          Length = 390

 Score =  107 bits (267), Expect = 2e-23
 Identities = 70/185 (37%), Positives = 101/185 (54%), Gaps = 22/185 (11%)

Query: 95  PDVAQFVLTEGNPRWEQTHLTYRIENYTPDL--PRADVDHAIEKAFQLWSNVTPLTFTKV 152
           P   ++ LT    RW+  +LTYRI ++  +L  PR +   A+  AF++WS+V+P +F +V
Sbjct: 74  PRRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPR-ETRRALAAAFRMWSDVSPFSFREV 132

Query: 153 SEGQ-ADIMISFVRGDHRD------NSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTN 205
           +  Q +D+ I F   +H D      +  FDGP G LAHAF P  G     HFD+ E W  
Sbjct: 133 APEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHG---GIHFDDSEYWVL 189

Query: 206 NFREYN---------LHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGI 256
               Y+         L  VAAHE+GH+LGL HS    ALM+ + T  G   L+QD++ G+
Sbjct: 190 GPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGL 249

Query: 257 QAIYG 261
             +YG
Sbjct: 250 HRLYG 254


>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
           sapiens]
          Length = 183

 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 59/150 (39%), Positives = 80/150 (53%), Gaps = 14/150 (9%)

Query: 37  YLEKYYNLKNDGRQVEKRRNSGP--VVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGV 94
           YL +Y  L+   + +E   N  P  + E L+  QE   L V+G+ D  T   M+QPRCG+
Sbjct: 31  YLSQYGYLQ---KPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGL 87

Query: 95  PD-----VAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTF 149
            D       +++L     RW + HLT+RI N    LP      A+ +AFQ WSNV PLTF
Sbjct: 88  EDPFNQKTLKYLLLG---RWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTF 144

Query: 150 TKVSEGQADIMISF-VRGDHRDNSPFDGPG 178
            +V  G ADI +SF  R     ++ FDGPG
Sbjct: 145 QEVQAGAADIRLSFHGRQSSYCSNTFDGPG 174


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.437 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,881,504
Number of Sequences: 37866
Number of extensions: 946586
Number of successful extensions: 2182
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 1905
Number of HSP's gapped (non-prelim): 90
length of query: 469
length of database: 18,247,518
effective HSP length: 106
effective length of query: 363
effective length of database: 14,233,722
effective search space: 5166841086
effective search space used: 5166841086
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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