BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo sapiens] (469 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H... 989 0.0 gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens] 855 0.0 gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens] 561 e-160 gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens] 526 e-149 gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens] 502 e-142 gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens] 458 e-129 gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi... 454 e-128 gi|73808268 matrix metalloproteinase 27 [Homo sapiens] 450 e-126 gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi... 407 e-113 gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens] 298 5e-81 gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ... 290 2e-78 gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens] 274 1e-73 gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens] 272 4e-73 gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi... 248 1e-65 gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap... 239 4e-63 gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens] 236 3e-62 gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens] 218 1e-56 gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [... 218 1e-56 gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein... 212 5e-55 gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot... 210 2e-54 gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi... 207 2e-53 gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ... 201 1e-51 gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens] 174 2e-43 gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi... 172 4e-43 gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens] 140 2e-33 gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi... 128 1e-29 gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens] 113 4e-25 gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens] 113 4e-25 gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens] 107 2e-23 gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ... 87 4e-17 >gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo sapiens] Length = 469 Score = 989 bits (2556), Expect = 0.0 Identities = 469/469 (100%), Positives = 469/469 (100%) Query: 1 MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV 60 MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV Sbjct: 1 MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV 60 Query: 61 VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN 120 VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN Sbjct: 61 VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN 120 Query: 121 YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN 180 YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN Sbjct: 121 YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN 180 Query: 181 LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY 240 LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY Sbjct: 181 LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY 240 Query: 241 TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR 300 TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR Sbjct: 241 TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR 300 Query: 301 FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY 360 FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY Sbjct: 301 FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY 360 Query: 361 PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP 420 PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP Sbjct: 361 PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP 420 Query: 421 GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 469 GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN Sbjct: 421 GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 469 >gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens] Length = 403 Score = 855 bits (2210), Expect = 0.0 Identities = 403/403 (100%), Positives = 403/403 (100%) Query: 67 MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 126 MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP Sbjct: 1 MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60 Query: 127 RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 186 RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ Sbjct: 61 RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120 Query: 187 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV 246 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV Sbjct: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV 180 Query: 247 QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN 306 QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN Sbjct: 181 QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN 240 Query: 307 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS 366 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS Sbjct: 241 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS 300 Query: 367 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV 426 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV Sbjct: 301 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV 360 Query: 427 DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 469 DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN Sbjct: 361 DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN 403 >gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens] Length = 467 Score = 561 bits (1445), Expect = e-160 Identities = 267/461 (57%), Positives = 342/461 (74%), Gaps = 7/461 (1%) Query: 9 LLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQ 68 LLL +S +FP + ++E++ VQ YLEK+Y L ++ Q ++ + +VEKLK+MQ Sbjct: 10 LLLLHVQISKAFPVS--SKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQ 67 Query: 69 EFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRA 128 FFGL VTGKP+ ETL +MK+PRCGVPD F+LT GNP+WE+T+LTYRI NYTP L A Sbjct: 68 RFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEA 127 Query: 129 DVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPG 188 +V+ AI+ AF+LWS +PL FT++S+G+ADI I+F + DH DNSPFDGP G LAHAFQPG Sbjct: 128 EVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPG 187 Query: 189 PGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SGDV 246 GIGGDAHFD +E WTN YNL VAAHE GHSLGL+HS+D GALMYP+Y F + + Sbjct: 188 QGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNY 247 Query: 247 QLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN 306 L QDDIDGIQAIYG S NP+QP GP TPK CD LTFDAITT+RGE++FFKDR++ R + Sbjct: 248 SLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRH 307 Query: 307 PFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYS 366 P VE+NFIS+FWP LP G++AAYE DRD + FKGN+YWA+ G ++L GYPKDI S Sbjct: 308 PQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDI-S 366 Query: 367 SFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV 426 ++GFP +V+ IDAA+ + KTYFFV +++WRYD ++ M+PGYPK I+ FPGI KV Sbjct: 367 NYGFPSSVQAIDAAVFYRS--KTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKV 424 Query: 427 DAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCR 467 DAVF ++ FF+ F G R Y FD +R+ + + N W NCR Sbjct: 425 DAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCR 465 >gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens] Length = 477 Score = 526 bits (1356), Expect = e-149 Identities = 255/478 (53%), Positives = 340/478 (71%), Gaps = 13/478 (2%) Query: 1 MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV 60 M S P LLLL ++ ++ ++LVQKYLE YY+LK D +Q +R++SGPV Sbjct: 1 MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60 Query: 61 VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN 120 V+K+++MQ+F GL+VTGK D++TL+VM++PRCGVPDV F G P+W +THLTYRI N Sbjct: 61 VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN 120 Query: 121 YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN 180 YTPDLP+ VD A+EKA ++W VTPLTF+++ EG+ADIMISF +H D PFDGPG Sbjct: 121 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV 180 Query: 181 LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY 240 LAHA+ PGPGI GDAHFD+DE+WT + NL VAAHE+GHSLGL HS + ALMYP Y Sbjct: 181 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 240 Query: 241 TFSGDV---QLAQDDIDGIQAIYGRSQN-------PVQPIGPQ--TPKACDSKLTFDAIT 288 D+ +L+QDDI+GIQ++YG + P +P+ P+ TP CD L+FDA++ Sbjct: 241 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS 300 Query: 289 TIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKY 348 T+RGE++ FKDR + R + E EL+ IS FWP LP+G++AAYE +D V FKGN++ Sbjct: 301 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF 360 Query: 349 WAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMD 408 WA++G V GYP+ I+ + GFP TV+ IDAA+S++ KTYFFV +KYWR+DE + SM+ Sbjct: 361 WAIRGNEVRAGYPRGIH-TLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSME 419 Query: 409 PGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 466 PG+PK IA DFPGI K+DAVF + GFFYFF G+ Q +FDP K++ K+NSW NC Sbjct: 420 PGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477 >gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens] Length = 476 Score = 502 bits (1293), Expect = e-142 Identities = 246/472 (52%), Positives = 334/472 (70%), Gaps = 16/472 (3%) Query: 9 LLLFWGVVSHSFPATLETQEQDV--DLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQ 66 L+L V ++P + +E+D DL Q+YLEKYYNL+ D +Q +R++S +V+K++ Sbjct: 7 LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQF-RRKDSNLIVKKIQG 65 Query: 67 MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 126 MQ+F GL+VTGK D +TL+VM++PRCGVPDV F G P+W +THLTYRI NYTPDLP Sbjct: 66 MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNYTPDLP 125 Query: 127 RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 186 R VD AIEKA ++W VTPLTF+++ EG+ADIMISF +H D FDGPG +LAHA+ Sbjct: 126 RDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYP 185 Query: 187 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYP---SYTFS 243 PGPG+ GD HFD+DE+WT + NL VAAHELGHSLGL HS + ALMYP S+T Sbjct: 186 PGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTEL 245 Query: 244 GDVQLAQDDIDGIQAIYG----RSQNPVQPI-----GPQTPKACDSKLTFDAITTIRGEV 294 +L+QDD++GIQ++YG ++ P+ P G + P CD L+FDAI+T+RGE Sbjct: 246 AQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTLRGEY 305 Query: 295 MFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQ 354 +FFKDR++ R + + PE E + IS FWP LP+ L+AAYE RD V FKGN++WA++G Sbjct: 306 LFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGN 365 Query: 355 NVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKM 414 V GYP+ I+ + GFP T++ IDAA+S++ KTYFF A+KYWR+DE +SM+ G+P++ Sbjct: 366 EVQAGYPRGIH-TLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRL 424 Query: 415 IAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 466 IA DFPG+ KVDAV GFFYFF G+ Q++FDP + + + K+NSW +C Sbjct: 425 IADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476 >gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens] Length = 471 Score = 458 bits (1178), Expect = e-129 Identities = 221/444 (49%), Positives = 296/444 (66%), Gaps = 4/444 (0%) Query: 25 ETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETL 84 + E+D+ ++YL YY+ N + K + + E+L++MQ FFGL+VTGK D TL Sbjct: 30 DLSEEDLQFAERYLRSYYHPTNLAG-ILKENAASSMTERLREMQSFFGLEVTGKLDDNTL 88 Query: 85 KVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNV 144 VMK+PRCGVPDV ++ + +W + +LTYRI NYTPD+ ++V+ A +KAF++WS+V Sbjct: 89 DVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDV 148 Query: 145 TPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT 204 TPL FT++ +G ADIMISF +H D PFDGP G LAHAF PGP GGDAHFD+DE WT Sbjct: 149 TPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWT 208 Query: 205 NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG--DVQLAQDDIDGIQAIYGR 262 ++ + YNL VAAHE GHSLGL HS D GALM+P YT++G L DD+ GIQ++YG Sbjct: 209 SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 268 Query: 263 SQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWP 322 P P+TP CD L+ DAIT++RGE M FKDRF+ R +P + EL FWP Sbjct: 269 GDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWP 328 Query: 323 QLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALS 382 +LPN ++AAYE D + F+G K+WA+ G ++L GYPK I S G P+ VK I AA+ Sbjct: 329 ELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKI-SELGLPKEVKKISAAVH 387 Query: 383 EENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGT 442 E+TGKT F N+ WRYD+ MD YP++I DFPGIG KVDAV+ K+G+ YFF+G Sbjct: 388 FEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGP 447 Query: 443 RQYKFDPKTKRILTLQKANSWFNC 466 Q+++ + RI+ + ANS C Sbjct: 448 IQFEYSIWSNRIVRVMPANSILWC 471 >gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapiens] Length = 470 Score = 454 bits (1168), Expect = e-128 Identities = 231/468 (49%), Positives = 306/468 (65%), Gaps = 9/468 (1%) Query: 7 LLLLLFWGVVSHSFPATLET--QEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVV-EK 63 LL+LL S + P T ++ +V ++YLEK+Y L+ + V K + SG ++ EK Sbjct: 4 LLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEK 63 Query: 64 LKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTP 123 +++MQ F GLKVTG+ D TL++M PRCGVPDV F G P W + ++TYRI NYTP Sbjct: 64 IQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTP 123 Query: 124 DLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAH 183 D+ R DVD+AI KAFQ+WSNVTPL F+K++ G ADI++ F RG H D FDG GG LAH Sbjct: 124 DMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAH 183 Query: 184 AFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF- 242 AF PG GIGGDAHFDEDE WT + NL A HE+GHSLGL HS+D A+M+P+Y + Sbjct: 184 AFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYV 243 Query: 243 -SGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQT--PKACDSKLTFDAITTIRGEVMFFKD 299 +L+ DDI GIQ++YG + + P P CD L+FDA+TT+ ++ FFKD Sbjct: 244 DINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKD 303 Query: 300 RFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHG 359 RF+ P+ +N IS WP LP+G+EAAYE R++V FK +KYW + Sbjct: 304 RFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPN 363 Query: 360 YPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDF 419 YPK I+ SFGFP VK IDAA+ +TYFFV N+YWRYDE ++ MDPGYPK+I +F Sbjct: 364 YPKSIH-SFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNF 422 Query: 420 PGIGHKVDAVF-MKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 466 GIG K+DAVF K+ ++YFF G+ Q+++D +RI K+NSWF C Sbjct: 423 QGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC 470 >gi|73808268 matrix metalloproteinase 27 [Homo sapiens] Length = 513 Score = 450 bits (1157), Expect = e-126 Identities = 233/467 (49%), Positives = 309/467 (66%), Gaps = 9/467 (1%) Query: 7 LLLLLFWGVVSHSFPATLETQ-EQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLK 65 LLL LF+ S +FP T+ E+++ L Q YL ++Y+L+ +G + + +N + +K++ Sbjct: 5 LLLFLFFITFSSAFPLVRMTENEENMQLAQAYLNQFYSLEIEGNHLVQSKNRSLIDDKIR 64 Query: 66 QMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDL 125 +MQ FFGL VTGK D+ TL++MK PRCGVPDV Q+ T P W + +LTYRI NYTPD+ Sbjct: 65 EMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGYTL--PGWRKYNLTYRIINYTPDM 122 Query: 126 PRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDH-RDNSPFDGPGGNLAHA 184 RA VD AI++ ++WS VTPL FTK+S+G ADIMI+F H R FDGP G L HA Sbjct: 123 ARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDGPLGVLGHA 182 Query: 185 FQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG 244 F PGPG+GGD HFDEDE WT + +NL VAAHE GH+LGLSHS D ALM+P+Y Sbjct: 183 FPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLD 242 Query: 245 DVQ--LAQDDIDGIQAIYGR-SQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRF 301 + L+QDDI+GIQ+IYG + P +P P P ACD LTFDAITT R EVMFFK R Sbjct: 243 PRKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRREVMFFKGRH 302 Query: 302 YMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYP 361 R +VE I+ FWP LP L+AAYE RD++ FK +W ++G VL YP Sbjct: 303 LWRIYYDITDVEFELIASFWPSLPADLQAAYE-NPRDKILVFKDENFWMIRGYAVLPDYP 361 Query: 362 KDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPG 421 K I++ GFP VK IDAA+ ++ T KTYFFV WR+DE ++MD G+P+ + FPG Sbjct: 362 KSIHT-LGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPG 420 Query: 422 IGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRK 468 I +VDA F GFF+F G++Q+++D KTK I + + N+WF C++ Sbjct: 421 ISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQCKE 467 >gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapiens] Length = 483 Score = 407 bits (1045), Expect = e-113 Identities = 207/458 (45%), Positives = 286/458 (62%), Gaps = 16/458 (3%) Query: 22 ATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKR--RNSGPVVEKLKQMQEFFGLKVTGKP 79 A+ T + L Q YL+KYY K +G Q+ + R S ++ K+K++Q FFGL+VTGK Sbjct: 29 ASPRTWRNNYRLAQAYLDKYYTNK-EGHQIGEMVARGSNSMIRKIKELQAFFGLQVTGKL 87 Query: 80 DAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQ 139 D T+ V+K+PRCGVPDVA + L G P+W++ LTYRI YTP + +VD A+E A Q Sbjct: 88 DQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKNTLTYRISKYTPSMSSVEVDKAVEMALQ 147 Query: 140 LWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDE 199 WS+ PL+F +++ G+ADIMISF GDH D+ PFDGP G LAHAF PG G+GGD HFD Sbjct: 148 AWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDN 207 Query: 200 DERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG--DVQLAQDDIDGIQ 257 E+WT +NL VAAHE GH+LGL+HSTD ALMYP+Y + L +DD+ GIQ Sbjct: 208 AEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQ 267 Query: 258 AIYGRSQ----NPVQPIG----PQTPKACDSKLTFDAITTIRGEVMFFKDR-FYMRTNPF 308 A+YG + P P P P CDS +FDA+T + E++ FKDR F+ R Sbjct: 268 ALYGPRKVFLGKPTLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLLFKDRIFWRRQVHL 327 Query: 309 YPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSF 368 + + I+ +PQL + ++AAYE A+R FFKG YW +G + G P+ IY F Sbjct: 328 RTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQ-MQGPPRTIY-DF 385 Query: 369 GFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDA 428 GFPR V+ IDAA+ KT FFV ++Y+ YDE KR M+ YPK +F G+ ++DA Sbjct: 386 GFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQIDA 445 Query: 429 VFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 466 +G+ YFF G + YK+D + + ++++ K++SW C Sbjct: 446 AVELNGYIYFFSGPKTYKYDTEKEDVVSVVKSSSWIGC 483 >gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens] Length = 645 Score = 298 bits (764), Expect = 5e-81 Identities = 190/473 (40%), Positives = 242/473 (51%), Gaps = 65/473 (13%) Query: 35 QKYLEKY-YNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCG 93 Q +L+ Y Y L D R ++ + + MQ+F+G+ VTG D T++ MK+PRCG Sbjct: 82 QNWLKSYGYLLPYDSR-ASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCG 140 Query: 94 VPDVAQFVLTEGNPR-------WEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTP 146 VPD N R W Q H+TY I NYTP + D AI +AF +W VTP Sbjct: 141 VPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTP 200 Query: 147 LTFTKV-------SEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDE 199 LTF +V +ADIMI F G H D+SPFDG GG LAHA+ PGPGIGGD HFD Sbjct: 201 LTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDS 260 Query: 200 DERWT---NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SGDVQLAQDDID 254 DE WT N +L VA HELGH+LGL HS+D A+M P Y + + + +L QDD+ Sbjct: 261 DEPWTLGNANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQ 320 Query: 255 GIQAIYGRSQNPVQPIGP------------------------------------QTPKAC 278 GIQ IYG P++P P P C Sbjct: 321 GIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNIC 380 Query: 279 DSKLTFDAITTIRGEVMFFKDRFYMR-TNPFYPEVELNFISVFWPQLPNGLEAAYEFADR 337 D F+ + RGE+ FKDR++ R N E I FW LP ++AAYE AD Sbjct: 381 DG--NFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADG 438 Query: 338 DEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKY 397 V FFKG+KYW + V GYP + G + ID AL E GKTYFF +Y Sbjct: 439 RFV-FFKGDKYWVFKEVTVEPGYPHSL-GELGSCLPREGIDTALRWEPVGKTYFFKGERY 496 Query: 398 WRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFM-KDGFF-YFFHGTRQYKFD 448 WRY E +R+ DPGYPK I + GI F+ K+G++ YF+ G +KFD Sbjct: 497 WRYSEERRATDPGYPKPIT-VWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFD 548 >gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein [Homo sapiens] Length = 607 Score = 290 bits (742), Expect = 2e-78 Identities = 180/483 (37%), Positives = 253/483 (52%), Gaps = 70/483 (14%) Query: 34 VQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCG 93 V+ +L+KY L ++ R++ + L MQ+F+G+ +TGK D T+ MK+PRCG Sbjct: 43 VEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102 Query: 94 VPDVAQ-----------FVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWS 142 VPD + + LT +W+ H+TY I+N TP + + AI +AF +W Sbjct: 103 VPDQTRGSSKFHIRRKRYALT--GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQ 160 Query: 143 NVTPLTFTKVSEGQ-------ADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDA 195 NVTPLTF +V + DI I F G H D+SPFDG GG LAHA+ PGPGIGGD Sbjct: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220 Query: 196 HFDEDERWT---NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SGDVQLAQ 250 HFD DE WT N +L VA HELGH+LGL HS D A+M P Y + + + +L Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280 Query: 251 DDIDGIQAIYG--------------------------RSQNPVQPIGPQT---------P 275 DD+ GIQ IYG R + +P P T P Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340 Query: 276 KACDSKLTFDAITTIRGEVMFFKDRFY--MRTNPFYPEVELNFISVFWPQLPNGLEAAYE 333 CD F+ + +R E+ FKD+++ +R N + I+ FW LP ++A YE Sbjct: 341 NICDG--NFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQ-ITYFWRGLPPSIDAVYE 397 Query: 334 FADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFV 393 +D + V FFKGNKYW + + GYP D+ + G ID+A+ E+ GKTYFF Sbjct: 398 NSDGNFV-FFKGNKYWVFKDTTLQPGYPHDLI-TLGSGIPPHGIDSAIWWEDVGKTYFFK 455 Query: 394 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFM--KDGFFYFFHGTRQYKFDPKT 451 ++YWRY E ++MDPGYPK I + GI F+ ++GF YF+ G +KF+ + Sbjct: 456 GDRYWRYSEEMKTMDPGYPKPIT-VWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQI 514 Query: 452 KRI 454 ++ Sbjct: 515 LKV 517 >gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens] Length = 669 Score = 274 bits (701), Expect = 1e-73 Identities = 179/500 (35%), Positives = 250/500 (50%), Gaps = 89/500 (17%) Query: 35 QKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGV 94 + +L Y L R + R++ + L +MQ F+G+ VTG D ET + MK+PRCGV Sbjct: 54 ENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGV 113 Query: 95 PDVAQF-VLTEGNPR------------WEQTHLTYRIENYTPDLPRADVDHAIEKAFQLW 141 PD QF V + N R W HLT+ I+NYT L A+ +AF++W Sbjct: 114 PD--QFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVW 171 Query: 142 SNVTPLTFTKVS--------EGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGG 193 TPL F +V + +ADIM+ F G H D+SPFDG GG LAHA+ PGPG+GG Sbjct: 172 EQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGG 231 Query: 194 DAHFDEDERWT---NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFS--GDVQL 248 D HFD DE WT + NL VA HELGH+LGL HS++ A+M P Y + + +L Sbjct: 232 DTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKL 291 Query: 249 AQDDIDGIQAIYG-----------------------------------------RSQNPV 267 +DD+ GIQ +YG R P Sbjct: 292 PEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPG 351 Query: 268 QPIGPQT--------PKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNF--- 316 P+ P+ P CD FD + +RGE+ FK R++ R + V N+ Sbjct: 352 PPVQPRATERPDQYGPNICDG--DFDTVAMLRGEMFVFKGRWFWRVR--HNRVLDNYPMP 407 Query: 317 ISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKH 376 I FW LP + AAYE D V FFKG++YW + N+ GYP+ + +S+G Sbjct: 408 IGHFWRGLPGDISAAYERQDGRFV-FFKGDRYWLFREANLEPGYPQPL-TSYGLGIPYDR 465 Query: 377 IDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKD--G 434 ID A+ E TG T+FF ++YWR++E + DPGYPK I+ + GI F+ + Sbjct: 466 IDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPIS-VWQGIPASPKGAFLSNDAA 524 Query: 435 FFYFFHGTRQYKFDPKTKRI 454 + YF+ GT+ +KFD + R+ Sbjct: 525 YTYFYKGTKYWKFDNERLRM 544 >gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens] Length = 582 Score = 272 bits (696), Expect = 4e-73 Identities = 183/497 (36%), Positives = 253/497 (50%), Gaps = 57/497 (11%) Query: 5 PPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKL 64 PP LLL + + A+L + + + +L++Y L + +R+ + + Sbjct: 7 PPRCLLLPLLTLGTAL-ASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAI 65 Query: 65 KQMQEFFGLKVTGKPDAETLKVMKQPRCGVPD---------VAQFVLTEGNPRWEQTHLT 115 MQ+F+GL+VTGK DA+T+K M++PRCGVPD V + +W+ +T Sbjct: 66 AAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEIT 125 Query: 116 YRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVS--------EGQADIMISFVRGD 167 + I+NYTP + AI KAF++W + TPL F +V E QADIMI F G Sbjct: 126 FCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGF 185 Query: 168 HRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYN---LHRVAAHELGHSL 224 H D++PFDG GG LAHA+ PGP IGGD HFD E WT + N + VA HELGH+L Sbjct: 186 HGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHAL 245 Query: 225 GLSHSTDIGALMYPSYTF--SGDVQLAQDDIDGIQAIYG-----------------RSQN 265 GL HS+D A+M P Y + + + L DD GIQ +YG R Sbjct: 246 GLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSV 305 Query: 266 PVQPIGP-QTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTN-----PFYPEVELNFISV 319 P +P P P CD FD + +RGE+ FK+R++ R YP I Sbjct: 306 PDKPKNPTYGPNICDG--NFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMP----IGQ 359 Query: 320 FWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDA 379 FW LP + AYE D V FFKG+K+W ++ GYPK I G IDA Sbjct: 360 FWRGLPASINTAYERKDGKFV-FFKGDKHWVFDEASLEPGYPKHI-KELGRGLPTDKIDA 417 Query: 380 ALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFM--KDGFFY 437 AL GKTYFF NKY+R++E R++D YPK I + GI FM + F Y Sbjct: 418 ALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNI-KVWEGIPESPRGSFMGSDEVFTY 476 Query: 438 FFHGTRQYKFDPKTKRI 454 F+ G + +KF+ + ++ Sbjct: 477 FYKGNKYWKFNNQKLKV 493 >gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapiens] Length = 488 Score = 248 bits (632), Expect = 1e-65 Identities = 159/399 (39%), Positives = 215/399 (53%), Gaps = 49/399 (12%) Query: 87 MKQPRCGVPDVA----------QFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEK 136 ++ PRCGVPD + +FVL+ G RWE+T LTYRI + L + V + + Sbjct: 75 LRPPRCGVPDPSDGLSARNRQKRFVLSGG--RWEKTDLTYRILRFPWQLVQEQVRQTMAE 132 Query: 137 AFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAH 196 A ++WS+VTPLTFT+V EG+ADIMI F R H D+ PFDGPGG LAHAF P GD H Sbjct: 133 ALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVH 192 Query: 197 FDEDERWT-NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDG 255 FD DE WT + + +L +VAAHE GH LGL H+T ALM YTF + L+ DD G Sbjct: 193 FDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRG 252 Query: 256 IQAIYGR------------------SQNPVQPIGPQT-PKACDSKLTFDAITTIRGEVMF 296 +Q +YG+ N + P+ P P AC++ +FDA++TIRGE+ F Sbjct: 253 VQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEA--SFDAVSTIRGELFF 310 Query: 297 FKDRFYMR-----TNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAV 351 FK F R P YP + S W LP+ ++AA+E A + + FF+G +YW Sbjct: 311 FKAGFVWRLRGGQLQPGYPAL----ASRHWQGLPSPVDAAFEDA-QGHIWFFQGAQYWVY 365 Query: 352 QGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGY 411 G+ + G P + + G R H E K YFF YWR+ R +D Sbjct: 366 DGEKPVLG-PAPL-TELGLVRFPVHAALVWGPEK-NKIYFFRGRDYWRFHPSTRRVDSPV 422 Query: 412 PKMIAHDFPGIGHKVDAVFM-KDGFFYFFHGTRQYKFDP 449 P+ A D+ G+ ++DA F DG+ YF G +KFDP Sbjct: 423 PRR-ATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDP 460 >gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sapiens] Length = 603 Score = 239 bits (610), Expect = 4e-63 Identities = 167/485 (34%), Positives = 237/485 (48%), Gaps = 52/485 (10%) Query: 6 PLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLK 65 PLLLLL G + +D+ L ++L ++ L + + + + + Sbjct: 24 PLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAIT 83 Query: 66 QMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPR--------WEQTHLTYR 117 MQ+F GL+ TG D TL +MK PRC +PD+ VLT+ R W + +L++R Sbjct: 84 AMQQFGGLEATGILDEATLALMKTPRCSLPDLP--VLTQARRRRQAPAPTKWNKRNLSWR 141 Query: 118 IENYTPDLPRAD--VDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFD 175 + + D P V + A ++WS++ PL F +V+ ADI I F + DH D PFD Sbjct: 142 VRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFD 201 Query: 176 GPGGNLAHAFQPG-PGIGGDAHFDEDERWTNNFREYNLH-----RVAAHELGHSLGLSHS 229 GPGG +AHAF PG GD HFD+DE WT FR + H VA HE GH++GLSH Sbjct: 202 GPGGTVAHAFFPGHHHTAGDTHFDDDEAWT--FRSSDAHGMDLFAVAVHEFGHAIGLSHV 259 Query: 230 TDIGALMYPSYTFS-GD---VQLAQDDIDGIQAIYG-------RSQNPVQPIGPQTPKAC 278 ++M P Y GD L +D + +YG +Q P+ P+ P Sbjct: 260 AAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNR 319 Query: 279 DS-----------KLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISV--FWPQLP 325 S FDA+ IRGE FFK +++ R V L + FW LP Sbjct: 320 SSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLP 379 Query: 326 ---NGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALS 382 + ++A YE ++ FFKG++YW + NV GYP+ + S F P IDAA S Sbjct: 380 LHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPV-SDFSLP--PGGIDAAFS 436 Query: 383 EENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKV-DAVFMKDGFFYFFHG 441 + +TYFF YWRYD++ R MDPGYP + + G+ + DA+ DG YFF G Sbjct: 437 WAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQ-SPLWRGVPSTLDDAMRWSDGASYFFRG 495 Query: 442 TRQYK 446 +K Sbjct: 496 QEYWK 500 >gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens] Length = 267 Score = 236 bits (602), Expect = 3e-62 Identities = 118/235 (50%), Positives = 156/235 (66%), Gaps = 11/235 (4%) Query: 35 QKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGV 94 Q YL+++Y ++ +N+ + KLK+MQ+FFGL +TG ++ +++M++PRCGV Sbjct: 36 QDYLKRFYLYDSE------TKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGV 89 Query: 95 PDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSE 154 PDVA++ L +P+W +TYRI +YT DLP VD + KA +W PL F KV Sbjct: 90 PDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVW 149 Query: 155 GQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTN-NFREYNLH 213 G ADIMI F RG H D+ PFDGPG LAHAF PG G+GGDAHFDEDERWT+ + N Sbjct: 150 GTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFL 209 Query: 214 RVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQ---LAQDDIDGIQAIYGRSQN 265 A HELGHSLG+ HS+D A+MYP+Y +GD Q L+QDDI GIQ +YG+ N Sbjct: 210 YAATHELGHSLGMGHSSDPNAVMYPTYG-NGDPQNFKLSQDDIKGIQKLYGKRSN 263 >gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens] Length = 610 Score = 218 bits (554), Expect = 1e-56 Identities = 115/285 (40%), Positives = 162/285 (56%), Gaps = 16/285 (5%) Query: 195 AHFDEDERWTNNF---REYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQD 251 A++D+D +W F + Y+L VAAHE GH++GL HS D GALM P YT++ + +L+QD Sbjct: 329 ANYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQD 386 Query: 252 DIDGIQAIYGRSQN------PVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRT 305 DI GIQ +YG S + P +GP TP+ C + FD I IRGE+ FFKDRF RT Sbjct: 387 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 446 Query: 306 -NPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDI 364 P + ++ FWP+LP ++A YE ++ FF GN+YW + GYPK + Sbjct: 447 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 506 Query: 365 YSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGH 424 +S G P V+ +DAA + KTY F +K+WRY+E K+ MDPG+PK+IA + I Sbjct: 507 -TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPD 565 Query: 425 KVDAV--FMKDGFFYFFHGTRQYKFDPKTKRILTLQKANS-WFNC 466 +DAV G YFF G K + ++ + + S W C Sbjct: 566 NLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 610 Score = 174 bits (442), Expect = 1e-43 Identities = 78/143 (54%), Positives = 103/143 (72%) Query: 62 EKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENY 121 + LK+MQ+FFGL TG D T++ M++PRCG PDVA + P+W++ +TYRI Y Sbjct: 22 DTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGY 81 Query: 122 TPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNL 181 TPDL VD A +AFQ+WS+VTPL F+++ +G+ADIMI+F R +H D PFDG G L Sbjct: 82 TPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLL 141 Query: 182 AHAFQPGPGIGGDAHFDEDERWT 204 AHAF PG G+GGD+HFD+DE WT Sbjct: 142 AHAFAPGTGVGGDSHFDDDELWT 164 >gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [Homo sapiens] Length = 660 Score = 218 bits (554), Expect = 1e-56 Identities = 115/285 (40%), Positives = 162/285 (56%), Gaps = 16/285 (5%) Query: 195 AHFDEDERWTNNF---REYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQD 251 A++D+D +W F + Y+L VAAHE GH++GL HS D GALM P YT++ + +L+QD Sbjct: 379 ANYDDDRKW--GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQD 436 Query: 252 DIDGIQAIYGRSQN------PVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRT 305 DI GIQ +YG S + P +GP TP+ C + FD I IRGE+ FFKDRF RT Sbjct: 437 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 496 Query: 306 -NPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDI 364 P + ++ FWP+LP ++A YE ++ FF GN+YW + GYPK + Sbjct: 497 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 556 Query: 365 YSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGH 424 +S G P V+ +DAA + KTY F +K+WRY+E K+ MDPG+PK+IA + I Sbjct: 557 -TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPD 615 Query: 425 KVDAV--FMKDGFFYFFHGTRQYKFDPKTKRILTLQKANS-WFNC 466 +DAV G YFF G K + ++ + + S W C Sbjct: 616 NLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC 660 Score = 177 bits (449), Expect = 2e-44 Identities = 84/175 (48%), Positives = 114/175 (65%), Gaps = 6/175 (3%) Query: 30 DVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQ 89 D +L +YL +Y + N + + LK+MQ+FFGL TG D T++ M++ Sbjct: 46 DKELAVQYLNTFYGCPKESC------NLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRK 99 Query: 90 PRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTF 149 PRCG PDVA + P+W++ +TYRI YTPDL VD A +AFQ+WS+VTPL F Sbjct: 100 PRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRF 159 Query: 150 TKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT 204 +++ +G+ADIMI+F R +H D PFDG G LAHAF PG G+GGD+HFD+DE WT Sbjct: 160 SRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 214 >gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein [Homo sapiens] Length = 457 Score = 212 bits (540), Expect = 5e-55 Identities = 137/371 (36%), Positives = 189/371 (50%), Gaps = 66/371 (17%) Query: 34 VQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCG 93 V+ +L+KY L ++ R++ + L MQ+F+G+ +TGK D T+ MK+PRCG Sbjct: 43 VEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCG 102 Query: 94 VPDVAQ-----------FVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWS 142 VPD + + LT +W+ H+TY I+N TP + + AI +AF +W Sbjct: 103 VPDQTRGSSKFHIRRKRYALT--GQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQ 160 Query: 143 NVTPLTFTKVSEGQ-------ADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDA 195 NVTPLTF +V + DI I F G H D+SPFDG GG LAHA+ PGPGIGGD Sbjct: 161 NVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDT 220 Query: 196 HFDEDERWT---NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTF--SGDVQLAQ 250 HFD DE WT N +L VA HELGH+LGL HS D A+M P Y + + + +L Sbjct: 221 HFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPN 280 Query: 251 DDIDGIQAIYG--------------------------RSQNPVQPIGPQT---------P 275 DD+ GIQ IYG R + +P P T P Sbjct: 281 DDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKP 340 Query: 276 KACDSKLTFDAITTIRGEVMFFKDRFY--MRTNPFYPEVELNFISVFWPQLPNGLEAAYE 333 CD F+ + +R E+ FKD+++ +R N + I+ FW LP ++A YE Sbjct: 341 NICDG--NFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQ-ITYFWRGLPPSIDAVYE 397 Query: 334 FADRDEVRFFK 344 +D + V FFK Sbjct: 398 NSDGNFV-FFK 407 Score = 29.3 bits (64), Expect = 8.0 Identities = 19/51 (37%), Positives = 26/51 (50%), Gaps = 3/51 (5%) Query: 390 YFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVF-MKDGFFYFF 439 + F +WR R MD GYP I + + G+ +DAV+ DG F FF Sbjct: 358 FVFKDQWFWRVRN-NRVMD-GYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406 >gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein [Homo sapiens] Length = 508 Score = 210 bits (535), Expect = 2e-54 Identities = 160/461 (34%), Positives = 225/461 (48%), Gaps = 48/461 (10%) Query: 37 YLEKYYNLKNDGRQVEKRRNSGP--VVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGV 94 YL +Y L+ + +E N P + E L+ QE L V+G+ D T M+QPRCG+ Sbjct: 31 YLSQYGYLQ---KPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGL 87 Query: 95 PD-----VAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTF 149 D +++L RW + HLT+RI N LP A+ +AFQ WSNV PLTF Sbjct: 88 EDPFNQKTLKYLLLG---RWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTF 144 Query: 150 TKVSEGQADIMISF-VRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT-NNF 207 +V G ADI +SF R ++ FDGPG LAHA P G HFDEDE WT + Sbjct: 145 QEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHADIPEL---GSVHFDEDEFWTEGTY 201 Query: 208 REYNLHRVAAHELGHSLGLSHSTDIGALMYPSYT-FSGDVQLAQDDIDGIQAIYGR---- 262 R NL +AAHE+GH+LGL HS ALM P Y + +L DD+ GIQA+YG+ Sbjct: 202 RGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPHFKLHPDDVAGIQALYGKKSPV 261 Query: 263 --------SQNPVQPIGPQTPK----ACDSKLTFDAITT-IRGEVMFFKDRFYMRTNPFY 309 ++ P P P P C S+L DA+ RG+ FK + + Sbjct: 262 IRDEEEEETELPTVPPVPTEPSPMPDPCSSEL--DAMMLGPRGKTYAFKGDYVWTVSDSG 319 Query: 310 PEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFG 369 P L +S W LP L+AA + FFKG+K W + G+PK + Sbjct: 320 PG-PLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKL----- 373 Query: 370 FPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAV 429 R ++DAAL K + F + YW++DE R+ YPK I F G+ ++ A Sbjct: 374 -NRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAA 432 Query: 430 F-MKDGFFYFFHGTRQYKFDP--KTKRILTLQKANSWFNCR 467 +DG YFF G ++ + + ++ +++W +CR Sbjct: 433 MSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCR 473 >gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapiens] Length = 562 Score = 207 bits (527), Expect = 2e-53 Identities = 157/487 (32%), Positives = 223/487 (45%), Gaps = 54/487 (11%) Query: 29 QDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMK 88 QDV L +L +Y L + ++ + + +K MQ F GL TG+ D T+ M+ Sbjct: 27 QDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMR 86 Query: 89 QPRCGVPDVAQFVLTEGNPR--------WEQTHLTYRIENY--TPDLPRADVDHAIEKAF 138 +PRC +PDV R W++ LT+R+ ++ + L + V + A Sbjct: 87 KPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSYAL 146 Query: 139 QLWSNVTPLTFTKVSEGQA---DIMISFVRGDHRDNSPFDGPGGNLAHAFQPGP-GIGGD 194 W + LTF +V Q DI+I F R H+D+ PFDG GG LAHAF PG I GD Sbjct: 147 MAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGD 206 Query: 195 AHFDEDERWTNNFRE---YNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFS-GD---VQ 247 HFD++E WT ++ +L VA HE GH+LGL HS+ ++M P Y GD + Sbjct: 207 THFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYR 266 Query: 248 LAQDDIDGIQAIYGRSQN-------------PVQPIGPQT-------PKACDSKLTFDAI 287 L+QDD DG+Q +YG++ P QP T P C+ FDAI Sbjct: 267 LSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEG--NFDAI 324 Query: 288 TTIRGEVMFFKDRFYMRTNPFYPEVELN--FISVFWPQLP---NGLEAAYEFADRDEVRF 342 IRGE FFK ++ R P V + FW LP ++AAY + Sbjct: 325 ANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILL 384 Query: 343 FKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDE 402 F G ++W Q + L G + + + G P + +DA S GKTY +YWRYDE Sbjct: 385 FSGPQFWVFQDRQ-LEGGARPL-TELGLP-PGEEVDAVFSWPQNGKTYLVRGRQYWRYDE 441 Query: 403 YKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDP---KTKRILTLQK 459 DPGYP+ ++ D G YFF G ++F KT+ Sbjct: 442 AAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPM 501 Query: 460 ANSWFNC 466 +W +C Sbjct: 502 GPNWLDC 508 >gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein [Homo sapiens] Length = 520 Score = 201 bits (511), Expect = 1e-51 Identities = 165/494 (33%), Positives = 233/494 (47%), Gaps = 69/494 (13%) Query: 8 LLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQM 67 L LL WG + PA QE + + +LEKY L QV K S + ++ Sbjct: 12 LQLLLWGHLDAQ-PAERGGQELRKE-AEAFLEKYGYLNE---QVPKAPTSTRFSDAIRAF 66 Query: 68 QEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVL-----------------------TE 104 Q L V+G D TL+ M +PRCGV D + + Sbjct: 67 QWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQ 126 Query: 105 GNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKV-SEGQADIMISF 163 GN +W + HL+YR+ N+ LP V A+ AFQLWSNV+ L F + + G ADI ++F Sbjct: 127 GN-KWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTF 185 Query: 164 VRGDHRD--NSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT-NNFREYNLHRVAAHEL 220 +GDH D + FDGPGG LAHAF P G+AHFD+DERW+ + R NL V AHE+ Sbjct: 186 FQGDHNDGLGNAFDGPGGALAHAFLPR---RGEAHFDQDERWSLSRRRGRNLFVVLAHEI 242 Query: 221 GHSLGLSHSTDIGALMYPSYTFSG-DVQLAQDDIDGIQAIYGR----------------- 262 GH+LGL+HS ALM P Y G D L+ DD+ +Q++YG+ Sbjct: 243 GHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTD 302 Query: 263 --SQNPVQPIG--PQT--PKACDSKLTFDAITTIRGEVMF-FKDRFYMRTNPFYPEVELN 315 + + P G P+T PK C S +FDAIT R + ++ FK + E Sbjct: 303 FETWDSYSPQGRRPETQGPKYCHS--SFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPR 360 Query: 316 FISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVK 375 + W LP +EAA + + FFKG + W +G + G P+ + + G PR Sbjct: 361 PLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQ-LCRAGGLPR--- 416 Query: 376 HIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMK-DG 434 H DAAL + F +Y+ ++P YP+ + D+ GI +V + DG Sbjct: 417 HPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSL-QDWGGIPEEVSGALPRPDG 475 Query: 435 FFYFFHGTRQYKFD 448 FF R ++ D Sbjct: 476 SIIFFRDDRYWRLD 489 >gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens] Length = 707 Score = 174 bits (440), Expect = 2e-43 Identities = 90/185 (48%), Positives = 114/185 (61%), Gaps = 4/185 (2%) Query: 20 FPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKP 79 FP L T D L ++YL +Y R E R S + L +Q+ L TG+ Sbjct: 31 FPGDLRTNLTDRQLAEEYLYRY----GYTRVAEMRGESKSLGPALLLLQKQLSLPETGEL 86 Query: 80 DAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQ 139 D+ TLK M+ PRCGVPD+ +F EG+ +W ++TY I+NY+ DLPRA +D A +AF Sbjct: 87 DSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFA 146 Query: 140 LWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDE 199 LWS VTPLTFT+V ADI+I F +H D PFDG G LAHAF PGPGI GDAHFD+ Sbjct: 147 LWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDD 206 Query: 200 DERWT 204 DE W+ Sbjct: 207 DELWS 211 Score = 100 bits (249), Expect = 3e-21 Identities = 89/314 (28%), Positives = 129/314 (41%), Gaps = 81/314 (25%) Query: 195 AHFDEDERWTNNF---REYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQD 251 ++FD D++W F + Y+L VAAHE GH+LGL HS+ ALMYP Y F+ L +D Sbjct: 377 SNFDSDKKW--GFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKD 434 Query: 252 DIDGIQAIYGRSQNP-----------------VQPIGPQT-------------------- 274 D++GI+ +YG P V P GP T Sbjct: 435 DVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPT 494 Query: 275 --PKACDSKLT---------------FDAITTIRGEVMFFKDRFYMR------TNPFYPE 311 P A S T FDAI I ++ FKD Y R + P P Sbjct: 495 GPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPF 554 Query: 312 VELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFP 371 + I+ WP LP L++ +E ++ FF G + W G +VL P+ + G Sbjct: 555 L----IADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLG--PRRL-DKLGLG 607 Query: 372 RTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGI--------G 423 V + AL GK F + WR+D + +DP + FPG+ Sbjct: 608 ADVAQVTGAL-RSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQ 666 Query: 424 HKVDAVFMKDGFFY 437 ++ A F +D F++ Sbjct: 667 YREKAYFCQDRFYW 680 >gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapiens] Length = 261 Score = 172 bits (437), Expect = 4e-43 Identities = 93/232 (40%), Positives = 129/232 (55%), Gaps = 10/232 (4%) Query: 32 DLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPR 91 D V+ Y +++ K + + + E Q+ + F T D + ++ QP Sbjct: 30 DFVEGYFHQFFLTKKESPLLTQ--------ETQTQLLQQFHRNGTDLLDMQMHALLHQPH 81 Query: 92 CGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTK 151 CGVPD + ++ G +W + LTYRI NY D+ + V +I A +WSNVTPL F + Sbjct: 82 CGVPDGSDTSISPGRCKWNKHTLTYRIINYPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQ 141 Query: 152 VSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYN 211 V G ADI +SF + H D PFDGPGG L HAF P G G HFD++E W+ + YN Sbjct: 142 VQNGDADIKVSFWQWAHEDGWPFDGPGGILGHAFLPNSGNPGVVHFDKNEHWSASDTGYN 201 Query: 212 LHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG--DVQLAQDDIDGIQAIYG 261 L VA HE+GHSLGL HS + ++MYP+Y + QL+ DDI IQ +YG Sbjct: 202 LFLVATHEIGHSLGLQHSGNQSSIMYPTYWYHDPRTFQLSADDIQRIQHLYG 253 >gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens] Length = 358 Score = 140 bits (353), Expect = 2e-33 Identities = 81/175 (46%), Positives = 98/175 (56%), Gaps = 45/175 (25%) Query: 36 KYLEK-YYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGV 94 KYLE YYNLK++ Q+ ++R+S PV+EKLKQMQ FFGLK Sbjct: 146 KYLENCYYNLKSEINQIGRQRDSSPVLEKLKQMQNFFGLKD------------------- 186 Query: 95 PDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSE 154 +NY P+LP+ DVD A KAF+LWSN + LTFT+ E Sbjct: 187 ------------------------QNYMPNLPQEDVDRATGKAFELWSNASALTFTRDFE 222 Query: 155 GQADIMISFV-RGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFR 208 + DI++SFV D DNSPF G G LAHAF PGPGIGGD HFD DE T +FR Sbjct: 223 SEGDIILSFVFLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFR 277 Score = 113 bits (282), Expect = 4e-25 Identities = 54/92 (58%), Positives = 68/92 (73%), Gaps = 3/92 (3%) Query: 336 DRDEVRF--FKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFV 393 D DE R F+ +K+W VQ +L GYP+D+YSSF FP VK IDAA+ E++TGKT+FFV Sbjct: 267 DNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFV 326 Query: 394 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHK 425 AN+YWRYDE +S+D GYPK+I D PGI K Sbjct: 327 ANEYWRYDENMQSVDAGYPKII-DDLPGISKK 357 Score = 29.6 bits (65), Expect = 6.1 Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 2/51 (3%) Query: 316 FISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQG--QNVLHGYPKDI 364 + S +P+ ++AA D + FF N+YW Q+V GYPK I Sbjct: 298 YSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPKII 348 >gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapiens] Length = 569 Score = 128 bits (321), Expect = 1e-29 Identities = 126/453 (27%), Positives = 180/453 (39%), Gaps = 112/453 (24%) Query: 60 VVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQ--------------FVLTEG 105 + E +++ Q L +G+ DA TL M +PRCGVPD+ + Sbjct: 85 LAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRR 144 Query: 106 NPR---------WE--------------QTHLTYRI--ENYTPDLPRADVDHAIEKAFQL 140 +PR W+ + L++R+ E + L AD + AF++ Sbjct: 145 SPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRM 204 Query: 141 WSNVTPLTFTK--VSEGQA-DIMISFVRGDHRD-NSPFDGPGGNLAHAFQPGPGIGGDAH 196 WS VTPL F + + G A DI + F RG H FDG G AHA++ G D H Sbjct: 205 WSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIH 259 Query: 197 FDEDERWTNNFRE--YNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV-QLAQDDI 253 FD+DE +T + +L +VA HE+GH LGL H+ G++M P+Y +L D Sbjct: 260 FDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDWSDR 319 Query: 254 DGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVE 313 IQ +YG + FD I R + Y EV Sbjct: 320 KAIQKLYGSCEGSFD-------------TAFDWIRKERNQ---------------YGEVM 351 Query: 314 LNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRT 373 + F FF+ + YW + +N Y I G+P Sbjct: 352 VRF----------------------STYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGI 389 Query: 374 VKH-IDAALS--EENTGKTYFFVANKYWRYDEYK------RSMDPGYPKMIAHDFPGIGH 424 H IDA + + YFF N+YWRYD K YPK+I+ FPGI Sbjct: 390 PTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPS 449 Query: 425 KVDAVF--MKDGFFYFFHGTRQYKFDPKTKRIL 455 +D F + YFF + + FD R+L Sbjct: 450 PLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVL 482 >gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens] Length = 198 Score = 113 bits (282), Expect = 4e-25 Identities = 57/105 (54%), Positives = 70/105 (66%), Gaps = 7/105 (6%) Query: 105 GNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFV 164 G +W++ +NY P+LP+ DVD A KAF+LWSN + LTFT+ E + DI++SFV Sbjct: 19 GIQKWQED------QNYMPNLPQEDVDRATGKAFELWSNASALTFTRDFESEGDIILSFV 72 Query: 165 -RGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFR 208 D DNSPF G G LAHAF PGPGIGGD HFD DE T +FR Sbjct: 73 FLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFR 117 Score = 113 bits (282), Expect = 4e-25 Identities = 54/92 (58%), Positives = 68/92 (73%), Gaps = 3/92 (3%) Query: 336 DRDEVRF--FKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFV 393 D DE R F+ +K+W VQ +L GYP+D+YSSF FP VK IDAA+ E++TGKT+FFV Sbjct: 107 DNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFV 166 Query: 394 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHK 425 AN+YWRYDE +S+D GYPK+I D PGI K Sbjct: 167 ANEYWRYDENMQSVDAGYPKII-DDLPGISKK 197 Score = 29.6 bits (65), Expect = 6.1 Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 2/51 (3%) Query: 316 FISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQG--QNVLHGYPKDI 364 + S +P+ ++AA D + FF N+YW Q+V GYPK I Sbjct: 138 YSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPKII 188 >gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens] Length = 198 Score = 113 bits (282), Expect = 4e-25 Identities = 54/92 (58%), Positives = 68/92 (73%), Gaps = 3/92 (3%) Query: 336 DRDEVRF--FKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFV 393 D DE R F+ +K+W VQ +L GYP+D+YSSF FP VK IDAA+ E++TGKT+FFV Sbjct: 107 DNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFV 166 Query: 394 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHK 425 AN+YWRYDE +S+D GYPK+I D PGI K Sbjct: 167 ANEYWRYDENMQSVDAGYPKII-DDLPGISKK 197 Score = 110 bits (276), Expect = 2e-24 Identities = 56/105 (53%), Positives = 69/105 (65%), Gaps = 7/105 (6%) Query: 105 GNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFV 164 G +W++ +NY P+LP+ DVD A KAF+LWS + LTFT+ E + DI++SFV Sbjct: 19 GIQKWQED------QNYMPNLPQEDVDRATGKAFELWSKASALTFTRDFESEGDIILSFV 72 Query: 165 -RGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFR 208 D DNSPF G G LAHAF PGPGIGGD HFD DE T +FR Sbjct: 73 FLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFR 117 Score = 29.6 bits (65), Expect = 6.1 Identities = 17/51 (33%), Positives = 25/51 (49%), Gaps = 2/51 (3%) Query: 316 FISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQG--QNVLHGYPKDI 364 + S +P+ ++AA D + FF N+YW Q+V GYPK I Sbjct: 138 YSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSVDAGYPKII 188 >gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens] Length = 390 Score = 107 bits (267), Expect = 2e-23 Identities = 70/185 (37%), Positives = 101/185 (54%), Gaps = 22/185 (11%) Query: 95 PDVAQFVLTEGNPRWEQTHLTYRIENYTPDL--PRADVDHAIEKAFQLWSNVTPLTFTKV 152 P ++ LT RW+ +LTYRI ++ +L PR + A+ AF++WS+V+P +F +V Sbjct: 74 PRRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPR-ETRRALAAAFRMWSDVSPFSFREV 132 Query: 153 SEGQ-ADIMISFVRGDHRD------NSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTN 205 + Q +D+ I F +H D + FDGP G LAHAF P G HFD+ E W Sbjct: 133 APEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHG---GIHFDDSEYWVL 189 Query: 206 NFREYN---------LHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGI 256 Y+ L VAAHE+GH+LGL HS ALM+ + T G L+QD++ G+ Sbjct: 190 GPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGL 249 Query: 257 QAIYG 261 +YG Sbjct: 250 HRLYG 254 >gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo sapiens] Length = 183 Score = 86.7 bits (213), Expect = 4e-17 Identities = 59/150 (39%), Positives = 80/150 (53%), Gaps = 14/150 (9%) Query: 37 YLEKYYNLKNDGRQVEKRRNSGP--VVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGV 94 YL +Y L+ + +E N P + E L+ QE L V+G+ D T M+QPRCG+ Sbjct: 31 YLSQYGYLQ---KPLEGSNNFKPEDITEALRAFQEASELPVSGQLDDATRARMRQPRCGL 87 Query: 95 PD-----VAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTF 149 D +++L RW + HLT+RI N LP A+ +AFQ WSNV PLTF Sbjct: 88 EDPFNQKTLKYLLLG---RWRKKHLTFRILNLPSTLPPHTARAALRQAFQDWSNVAPLTF 144 Query: 150 TKVSEGQADIMISF-VRGDHRDNSPFDGPG 178 +V G ADI +SF R ++ FDGPG Sbjct: 145 QEVQAGAADIRLSFHGRQSSYCSNTFDGPG 174 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.139 0.437 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,881,504 Number of Sequences: 37866 Number of extensions: 946586 Number of successful extensions: 2182 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 40 Number of HSP's successfully gapped in prelim test: 11 Number of HSP's that attempted gapping in prelim test: 1905 Number of HSP's gapped (non-prelim): 90 length of query: 469 length of database: 18,247,518 effective HSP length: 106 effective length of query: 363 effective length of database: 14,233,722 effective search space: 5166841086 effective search space used: 5166841086 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.