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Search of human proteins with 4505211
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505211 matrix metalloproteinase 15 preproprotein [Homo
sapiens]
(669 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens] 1431 0.0
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ... 705 0.0
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens] 693 0.0
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens] 689 0.0
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein... 477 e-134
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi... 389 e-108
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap... 361 1e-99
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens] 303 4e-82
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens] 303 4e-82
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi... 295 7e-80
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi... 290 3e-78
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens] 276 3e-74
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens] 274 2e-73
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H... 274 2e-73
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens] 266 6e-71
gi|73808268 matrix metalloproteinase 27 [Homo sapiens] 261 1e-69
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi... 258 1e-68
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot... 250 3e-66
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ... 236 4e-62
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens] 204 3e-52
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [... 204 3e-52
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens] 197 2e-50
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi... 151 2e-36
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens] 141 2e-33
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi... 107 4e-23
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens] 91 4e-18
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ... 84 4e-16
gi|88853069 vitronectin precursor [Homo sapiens] 77 7e-14
gi|11321561 hemopexin precursor [Homo sapiens] 65 3e-10
gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens] 64 3e-10
>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
Length = 669
Score = 1431 bits (3705), Expect = 0.0
Identities = 669/669 (100%), Positives = 669/669 (100%)
Query: 1 MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLY 60
MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLY
Sbjct: 1 MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLY 60
Query: 61 GYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVR 120
GYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVR
Sbjct: 61 GYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVR 120
Query: 121 VKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQ 180
VKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQ
Sbjct: 121 VKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQ 180
Query: 181 EVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEP 240
EVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEP
Sbjct: 181 EVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEP 240
Query: 241 WTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQ 300
WTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQ
Sbjct: 241 WTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQ 300
Query: 301 QLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATE 360
QLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATE
Sbjct: 301 QLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATE 360
Query: 361 RPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDIS 420
RPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDIS
Sbjct: 361 RPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDIS 420
Query: 421 AAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFF 480
AAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFF
Sbjct: 421 AAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFF 480
Query: 481 FQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNE 540
FQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNE
Sbjct: 481 FQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNE 540
Query: 541 RLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGD 600
RLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGD
Sbjct: 541 RLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGD 600
Query: 601 FGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLY 660
FGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLY
Sbjct: 601 FGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLY 660
Query: 661 CKRSLQEWV 669
CKRSLQEWV
Sbjct: 661 CKRSLQEWV 669
>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
[Homo sapiens]
Length = 607
Score = 705 bits (1819), Expect = 0.0
Identities = 342/639 (53%), Positives = 438/639 (68%), Gaps = 56/639 (8%)
Query: 33 LLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGI 92
L LL L V + + E WL+ YGYLP MS +RSA+ + SALA MQ+FYGI
Sbjct: 23 LQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGI 82
Query: 93 PVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYT 152
+TG +D T +WMK+PRCGVPDQ R + RRKRYALTG+KW + H+T+SI+N T
Sbjct: 83 NMTGKVDRNTIDWMKKPRCGVPDQ--TRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVT 140
Query: 153 EKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPF 212
K+G + +A+RRAF VW+ TPL F+EVPY ++ +++ DI ++FASGFHGDSSPF
Sbjct: 141 PKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELE-NGKRDVDITIIFASGFHGDSSPF 199
Query: 213 DGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSN 272
DG GGFLAHAYFPGPG+GGDTHFD+DEPWT + + GN+LFLVAVHELGHALGLEHS++
Sbjct: 200 DGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSND 259
Query: 273 PNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPP 332
P AIMAPFYQ+ + DNFKLP DDL+GIQ++YG PD P PT+PLPTV P R PP
Sbjct: 260 PTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRS-----IPP 314
Query: 333 RPPQPPPPGGKPERPPKPGPPVQPRATERPDQYG--PNICDGDFDTVAMLRGEMFVFKGR 390
P+ K +RP P PP T RP G PNICDG+F+T+A+LR EMFVFK +
Sbjct: 315 ADPR------KNDRPKPPRPP-----TGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQ 363
Query: 391 WFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGY 450
WFWRVR+NRV+D YPM I +FWRGLP I A YE DG FVFFKG++YW+F++ L+PGY
Sbjct: 364 WFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGY 423
Query: 451 PQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGI 510
P L + G GIP ID+AIWWE G T+FF+ DRYWR++EE + DPGYPKPI+VW+GI
Sbjct: 424 PHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGI 483
Query: 511 PASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPRWP 570
P SP+GAF+ + +TYFYKG +YWKF+N+ L++EPGYP+SIL+DFMGC P R
Sbjct: 484 PESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCD---GPTDRVK 540
Query: 571 DVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQMEEVARTVNVVMVL 630
+ PP D + +V++++ A TV + ++
Sbjct: 541 EGHSPP-----------DDVD---------------------IVIKLDNTASTVKAIAIV 568
Query: 631 VPLLLLLCVLGLTYALVQMQRKGAPRVLLYCKRSLQEWV 669
+P +L LC+L L Y + Q +RKG PR +LYCKRS+QEWV
Sbjct: 569 IPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV 607
>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
Length = 645
Score = 693 bits (1789), Expect = 0.0
Identities = 352/669 (52%), Positives = 444/669 (66%), Gaps = 84/669 (12%)
Query: 28 RLLPLLLVLLGCL-----------GLG---------VAAEDAEVH--AENWLRLYGYLPQ 65
RLL LLL L CL G G A++AE +NWL+ YGYL
Sbjct: 34 RLLLLLLPALCCLPGAARAAAAAAGAGNRAAVAVAVARADEAEAPFAGQNWLKSYGYLLP 93
Query: 66 PSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANL 125
S + SA+ L SA++ MQ+FYGIPVTGVLD+ T EWMK+PRCGVPD +
Sbjct: 94 YDSRASALHSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDH----PHLSR 149
Query: 126 RRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYE 185
RRR KRYALTG+KW H+T+SI NYT K+G + +A+R+AF VW++ TPL F+EVPY
Sbjct: 150 RRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYH 209
Query: 186 DIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSS 245
+I+ R KEADIM+ FASGFHGDSSPFDG GGFLAHAYFPGPG+GGDTHFD+DEPWT +
Sbjct: 210 EIKSDR-KEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGN 268
Query: 246 TDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGT 305
+ GN+LFLVAVHELGHALGLEHSS+P+AIMAPFYQ+ + NFKLP+DDL+GIQ++YG
Sbjct: 269 ANHDGNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGP 328
Query: 306 PDGQPQPTQPLPTVTPRRPGRPDHRP----PRPPQPPPPGGKPERPPKPGPPVQPRATER 361
P +PT+PLPT+ RR P R PRPP+PP +RP PG
Sbjct: 329 PAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPP----LGDRPSTPGTK-------- 376
Query: 362 PDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISA 421
PNICDG+F+TVA+ RGEMFVFK RWFWR+R+NRV + YPM I FW+GLP I A
Sbjct: 377 -----PNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDA 431
Query: 422 AYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFF 481
AYER DGRFVFFKGD+YW+F+E +EPGYP L G +P + IDTA+ WEP G T+FF
Sbjct: 432 AYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFF 491
Query: 482 QEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNER 541
+ +RYWR++EE + DPGYPKPI+VW+GIP +P+GAF+S + YTYFYKG YWKFDN++
Sbjct: 492 KGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQK 551
Query: 542 LRMEPGYPKSILRDFMGC-QEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGD 600
L +EPGYP++ILRD+MGC Q+ VE E + D D
Sbjct: 552 LSVEPGYPRNILRDWMGCNQKEVE-----------------------RRKERRLPQDDVD 588
Query: 601 FGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLY 660
++V + +V +VN V V++P +L LC+L L Y + Q + K P+ + Y
Sbjct: 589 ------------IMVTINDVPGSVNAVAVVIPCILSLCILVLVYTIFQFKNKTGPQPVTY 636
Query: 661 CKRSLQEWV 669
KR +QEWV
Sbjct: 637 YKRPVQEWV 645
>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
Length = 582
Score = 689 bits (1779), Expect = 0.0
Identities = 342/642 (53%), Positives = 431/642 (67%), Gaps = 72/642 (11%)
Query: 29 LLPLLLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQR 88
LLPLL + LG +A+ + E WL+ YGYLP T RS Q L++A+A MQ+
Sbjct: 12 LLPLLTLGTALASLG-SAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQK 70
Query: 89 FYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSI 148
FYG+ VTG D +T + M+RPRCGVPD+FG +KAN+RR KRYA+ G KW ++ +TF I
Sbjct: 71 FYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRR--KRYAIQGLKWQHNEITFCI 128
Query: 149 QNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGD 208
QNYT K+G Y + EA+R+AFRVWE ATPL F+EVPY IR +K+ADIM+ FA GFHGD
Sbjct: 129 QNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGD 188
Query: 209 SSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLE 268
S+PFDG GGFLAHAYFPGP +GGDTHFD+ EPWT + DL+GN++FLVAVHELGHALGLE
Sbjct: 189 STPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLE 248
Query: 269 HSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPD 328
HSS+P+AIMAPFYQW D +NF LP+DD RGIQQLYG G P P P T R
Sbjct: 249 HSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSR------ 302
Query: 329 HRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFK 388
P P KP P YGPNICDG+FDTVAMLRGEMFVFK
Sbjct: 303 ---------------PSVPDKPKNPT----------YGPNICDGNFDTVAMLRGEMFVFK 337
Query: 389 GRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEP 448
RWFWRVR+N+V+D YPMPIG FWRGLP I+ AYER+DG+FVFFKGD++W+F EA+LEP
Sbjct: 338 ERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEP 397
Query: 449 GYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQ 508
GYP+ + G G+P D+ID A++W P G T+FF+ ++Y+RFNEE + D YPK I VW+
Sbjct: 398 GYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWE 457
Query: 509 GIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPR 568
GIP SP+G+F+ +D +TYFYKG KYWKF+N++L++EPGYPKS LRD+MGC
Sbjct: 458 GIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGC--------- 508
Query: 569 WPDVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQM-EEVARTVNVV 627
P GG E +V +++++ EE V+
Sbjct: 509 ----------PSGGRPDEGTEEETEV------------------IIIEVDEEGGGAVSAA 540
Query: 628 MVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLYCKRSLQEWV 669
V++P+LLLL VL + A+ +R G PR LLYC+RSL + V
Sbjct: 541 AVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV 582
>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
[Homo sapiens]
Length = 457
Score = 477 bits (1227), Expect = e-134
Identities = 234/404 (57%), Positives = 286/404 (70%), Gaps = 21/404 (5%)
Query: 33 LLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGI 92
L LL L V + + E WL+ YGYLP MS +RSA+ + SALA MQ+FYGI
Sbjct: 23 LQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGI 82
Query: 93 PVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYT 152
+TG +D T +WMK+PRCGVPDQ R + RRKRYALTG+KW + H+T+SI+N T
Sbjct: 83 NMTGKVDRNTIDWMKKPRCGVPDQ--TRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVT 140
Query: 153 EKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPF 212
K+G + +A+RRAF VW+ TPL F+EVPY ++ +++ DI ++FASGFHGDSSPF
Sbjct: 141 PKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELE-NGKRDVDITIIFASGFHGDSSPF 199
Query: 213 DGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSN 272
DG GGFLAHAYFPGPG+GGDTHFD+DEPWT + + GN+LFLVAVHELGHALGLEHS++
Sbjct: 200 DGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSND 259
Query: 273 PNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPP 332
P AIMAPFYQ+ + DNFKLP DDL+GIQ++YG PD P PT+PLPTV PP
Sbjct: 260 PTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTV-----------PP 308
Query: 333 RPPQPPPPGGKPERPPKPGPPVQPRATERPDQYG--PNICDGDFDTVAMLRGEMFVFKGR 390
PP K +RP P PP T RP G PNICDG+F+T+A+LR EMFVFK +
Sbjct: 309 HRSIPPADPRKNDRPKPPRPP-----TGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQ 363
Query: 391 WFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFK 434
WFWRVR+NRV+D YPM I +FWRGLP I A YE DG FVFFK
Sbjct: 364 WFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFK 407
Score = 30.8 bits (68), Expect = 4.2
Identities = 15/51 (29%), Positives = 26/51 (50%), Gaps = 3/51 (5%)
Query: 479 FFFQEDRYWRFNEETQRGDPGYPKPISV-WQGIPASPKGAFLSNDAAYTYF 528
F F++ +WR R GYP I+ W+G+P S + ++D + +F
Sbjct: 358 FVFKDQWFWRVRNN--RVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFF 406
>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
sapiens]
Length = 562
Score = 389 bits (999), Expect = e-108
Identities = 231/565 (40%), Positives = 311/565 (55%), Gaps = 61/565 (10%)
Query: 26 RPRLLPLLLVLLG--CLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASAL 83
R RLL LLL+LL +A+D + + WL YGYLP P + ++S + L A+
Sbjct: 4 RLRLLALLLLLLAPPARAPKPSAQDVSLGVD-WLTRYGYLPPPHPAQAQLQSPEKLRDAI 62
Query: 84 AEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHH 143
MQRF G+P TG +D T M++PRC +PD GV A L RRR+RYAL+G W
Sbjct: 63 KVMQRFAGLPETGRMDPGTVATMRKPRCSLPDVLGV---AGLVRRRRRYALSGSVWKKRT 119
Query: 144 LTFSIQNYTEKLGWYHSMEAVR----RAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMV 199
LT+ ++++ + S E VR A W + L F EV + +E DI++
Sbjct: 120 LTWRVRSFPQSSQL--SQETVRVLMSYALMAWGMESGLTFHEVDSP-----QGQEPDILI 172
Query: 200 LFASGFHGDSSPFDGTGGFLAHAYFPGPG-LGGDTHFDADEPWTFSSTDLHGNNLFLVAV 258
FA FH DS PFDG GG LAHA+FPG + GDTHFD +E WTF S D G +LF VAV
Sbjct: 173 DFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFGSKDGEGTDLFAVAV 232
Query: 259 HELGHALGLEHSSNPNAIMAPFYQWK--DVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPL 316
HE GHALGL HSS PN+IM PFYQ D D ++L +DD G+QQLYG
Sbjct: 233 HEFGHALGLGHSSAPNSIMRPFYQGPVGDPDKYRLSQDDRDGLQQLYG------------ 280
Query: 317 PTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDT 376
+ P P +P R P PP P PP P T P P+ C+G+FD
Sbjct: 281 -----KAPQTPYDKPTRKPLAPP----------PQPPASP--THSPSFPIPDRCEGNFDA 323
Query: 377 VAMLRGEMFVFKGRWFWRVR-HNRVLDNYPMPIGHFWRGLPGD---ISAAYER-QDGRFV 431
+A +RGE F FKG WFWR++ +++ P + FW GLP + AAY R +DGR +
Sbjct: 324 IANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRIL 383
Query: 432 FFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNE 491
F G ++W+F++ LE G +PLT GL P + +D W G T+ + +YWR++E
Sbjct: 384 LFSGPQFWVFQDRQLEGG-ARPLTELGLP-PGEEVDAVFSWPQNGKTYLVRGRQYWRYDE 441
Query: 492 ETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKS 551
R DPGYP+ +S+W+G P SP +SN A TYF+KG YW+F ++ EP P+
Sbjct: 442 AAARPDPGYPRDLSLWEGAPPSPDDVTVSN-AGDTYFFKGAHYWRFPKNSIKTEPDAPQP 500
Query: 552 ILRDFMGCQEHVEPGPRWPDVARPP 576
+ +++ C GPR P RPP
Sbjct: 501 MGPNWLDCPA-PSSGPRAP---RPP 521
>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
sapiens]
Length = 603
Score = 361 bits (926), Expect = 1e-99
Identities = 218/571 (38%), Positives = 300/571 (52%), Gaps = 65/571 (11%)
Query: 30 LPLLLVLL-----GCLGLGVA--AEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASA 82
LPLLL+L GC A AED + E WL +GYLP +++ + L+ A
Sbjct: 23 LPLLLLLALGTRGGCAAPAPAPRAEDLSLGVE-WLSRFGYLPPADPTTGQLQTQEELSKA 81
Query: 83 LAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNH 142
+ MQ+F G+ TG+LDE T MK PRC +PD + V RRRR+ A T KWN
Sbjct: 82 ITAMQQFGGLEATGILDEATLALMKTPRCSLPD---LPVLTQARRRRQAPAPT--KWNKR 136
Query: 143 HLTFSIQNYTEK--LGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVL 200
+L++ ++ + LG + A +VW PL F EV ADI +
Sbjct: 137 NLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVA--------GSAADIQID 188
Query: 201 FASGFHGDSSPFDGTGGFLAHAYFPGPG-LGGDTHFDADEPWTFSSTDLHGNNLFLVAVH 259
F+ H D PFDG GG +AHA+FPG GDTHFD DE WTF S+D HG +LF VAVH
Sbjct: 189 FSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGMDLFAVAVH 248
Query: 260 ELGHALGLEHSSNPNAIMAPFYQWK--DVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLP 317
E GHA+GL H + ++IM P+YQ D + LP +D + QLYG + P
Sbjct: 249 EFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESVS------P 302
Query: 318 TVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTV 377
T P P P P PP + PP+ P+ C FD V
Sbjct: 303 TAQPEEP---------PLLPEPPDNRSSAPPRKDV--------------PHRCSTHFDAV 339
Query: 378 AMLRGEMFVFKGRWFWRVRHNR-VLDNYPMPIGHFWRGLP---GDISAAYER-QDGRFVF 432
A +RGE F FKG++FWR+ +R ++ P + FWRGLP + A YER D + VF
Sbjct: 340 AQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVF 399
Query: 433 FKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEE 492
FKGDRYW+F++ N+E GYP+P++ + L P ID A W T+FF++ YWR+++
Sbjct: 400 FKGDRYWVFKDNNVEEGYPRPVSDFSL--PPGGIDAAFSWAHNDRTYFFKDQLYWRYDDH 457
Query: 493 TQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSI 552
T+ DPGYP +W+G+P++ A +D A +YF++G +YWK + L + PGYP+S
Sbjct: 458 TRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGA-SYFFRGQEYWKVLDGELEVAPGYPQST 516
Query: 553 LRDFMGCQEHVEPG--PRWPDVARPPFNPHG 581
RD++ C + G D A P P G
Sbjct: 517 ARDWLVCGDSQADGSVAAGVDAAEGPRAPPG 547
>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
Length = 467
Score = 303 bits (775), Expect = 4e-82
Identities = 185/519 (35%), Positives = 260/519 (50%), Gaps = 85/519 (16%)
Query: 28 RLLPLLLVLLGCLGLGVAAEDAEVHA---ENWLRLYGYLPQPSRHMSTMRSAQILASALA 84
+ LP LL+L + E + +++L + LP + ++ L
Sbjct: 5 KTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLK 64
Query: 85 EMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHL 144
EMQRF+G+ VTG +EET + MK+PRCGVPD G + KW +L
Sbjct: 65 EMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPG-----------NPKWERTNL 113
Query: 145 TFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASG 204
T+ I+NYT +L A++ AF +W A+PL+F + Q EADI + F
Sbjct: 114 TYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRIS--------QGEADINIAFYQR 165
Query: 205 FHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHA 264
HGD+SPFDG G LAHA+ PG G+GGD HFDA+E WT +S + NLFLVA HE GH+
Sbjct: 166 DHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANY---NLFLVAAHEFGHS 222
Query: 265 LGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRP 324
LGL HSS+P A+M P Y +++ N+ LP+DD+ GIQ +YG QPT P TP+
Sbjct: 223 LGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGP---STPK-- 277
Query: 325 GRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEM 384
P P T FD + LRGE+
Sbjct: 278 ----------------------------PCDPSLT--------------FDAITTLRGEI 295
Query: 385 FVFKGRWFWRVRH---NRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVF-FKGDRYWL 440
FK R+FWR RH RV N+ I FW LP I AAYE D +F FKG++YW
Sbjct: 296 LFFKDRYFWR-RHPQLQRVEMNF---ISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWA 351
Query: 441 FREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGY 500
++ GYP+ +++YG ID A+++ T+FF D++WR++ + Q +PGY
Sbjct: 352 LSGYDILQGYPKDISNYGFPSSVQAIDAAVFYR--SKTYFFVNDQFWRYDNQRQFMEPGY 409
Query: 501 PKPIS-VWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFD 538
PK IS + GI + F + + + G +Y+ FD
Sbjct: 410 PKSISGAFPGIESKVDAVF--QQEHFFHVFSGPRYYAFD 446
>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
Length = 477
Score = 303 bits (775), Expect = 4e-82
Identities = 196/520 (37%), Positives = 261/520 (50%), Gaps = 73/520 (14%)
Query: 27 PRLLPLLLVLLGCLGLGVAA--EDAEVH-AENWLRLYGYLPQPSRHMSTMRSAQILASAL 83
P LL L + + L AA ED ++ + +L Y L + + + + + +
Sbjct: 5 PILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKI 64
Query: 84 AEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHH 143
EMQ+F G+ VTG LD +T E M++PRCGVPD R + KW H
Sbjct: 65 REMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIP-----------KWRKTH 113
Query: 144 LTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFAS 203
LT+ I NYT L AV +A +VWE+ TPL F + YE EADIM+ FA
Sbjct: 114 LTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRL-YEG-------EADIMISFAV 165
Query: 204 GFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGH 263
HGD PFDG G LAHAY PGPG+ GD HFD DE WT +T G NLFLVA HE+GH
Sbjct: 166 REHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTT---GTNLFLVAAHEIGH 222
Query: 264 ALGLEHSSNPNAIMAPFY-QWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPR 322
+LGL HS+N A+M P Y D+ F+L +DD+ GIQ LYG P P+ TP
Sbjct: 223 SLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPE--------TPL 274
Query: 323 RPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDG--DFDTVAML 380
P P PP+PG P CD FD V+ L
Sbjct: 275 VPTEP------------------VPPEPGTPAN--------------CDPALSFDAVSTL 302
Query: 381 RGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVF-FKGDRYW 439
RGE+ +FK R FWR + R L+ I FW LP + AAYE VF FKG+++W
Sbjct: 303 RGEILIFKDRHFWR-KSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFW 361
Query: 440 LFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPG 499
R + GYP+ + + G +ID AI + T+FF ED+YWRF+E+ +PG
Sbjct: 362 AIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPG 421
Query: 500 YPKPISV-WQGIPASPKGAFLSNDAAYTYFYKGTKYWKFD 538
+PK I+ + GI + F + + YF+ G+ +FD
Sbjct: 422 FPKQIAEDFPGIDSKIDAVF--EEFGFFYFFTGSSQLEFD 459
>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
sapiens]
Length = 470
Score = 295 bits (756), Expect = 7e-80
Identities = 177/468 (37%), Positives = 236/468 (50%), Gaps = 75/468 (16%)
Query: 75 SAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYAL 134
S ++ + EMQ F G+ VTG LD T E M PRCGVPD R
Sbjct: 56 SGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPG---------- 105
Query: 135 TGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKE 194
G W H++T+ I NYT + A+R+AF+VW TPL F ++
Sbjct: 106 -GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKI--------NTGM 156
Query: 195 ADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLF 254
ADI+V+FA G HGD FDG GG LAHA+ PG G+GGD HFD DE WT T G NLF
Sbjct: 157 ADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWT---THSGGTNLF 213
Query: 255 LVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQ 314
L AVHE+GH+LGL HSS+P A+M P Y++ D++ F+L DD+RGIQ LY G P+ Q
Sbjct: 214 LTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLY----GDPKENQ 269
Query: 315 PLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGD- 373
LP PD P +CD +
Sbjct: 270 RLP-------------------------------------------NPDNSEPALCDPNL 286
Query: 374 -FDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVF 432
FD V + ++F FK R+FW R + + I W LP I AAYE + VF
Sbjct: 287 SFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNL-ISSLWPTLPSGIEAAYEIEARNQVF 345
Query: 433 -FKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNE 491
FK D+YWL EP YP+ + S+G +ID A++ T+FF +++YWR++E
Sbjct: 346 LFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDE 405
Query: 492 ETQRGDPGYPKPISV-WQGIPASPKGAFLSNDAAYTYFYKGTKYWKFD 538
Q DPGYPK I+ +QGI F S + Y YF++G+ +++D
Sbjct: 406 RRQMMDPGYPKLITKNFQGIGPKIDAVFYSKN-KYYYFFQGSNQFEYD 452
Score = 66.2 bits (160), Expect = 9e-11
Identities = 43/134 (32%), Positives = 66/134 (49%), Gaps = 7/134 (5%)
Query: 428 GRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYW 487
G +FF DR++ + + ++S +P I+ A E F F++D+YW
Sbjct: 295 GNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLP-SGIEAAYEIEARNQVFLFKDDKYW 353
Query: 488 RFNEETQRGDPGYPKPISVWQGIPASPK--GAFLSNDAAY-TYFYKGTKYWKFDNERLRM 544
+ R +P YPK I + G P K A + N Y TYF+ +YW++D R M
Sbjct: 354 LISN--LRPEPNYPKSIHSF-GFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMM 410
Query: 545 EPGYPKSILRDFMG 558
+PGYPK I ++F G
Sbjct: 411 DPGYPKLITKNFQG 424
>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
sapiens]
Length = 488
Score = 290 bits (742), Expect = 3e-78
Identities = 186/541 (34%), Positives = 256/541 (47%), Gaps = 66/541 (12%)
Query: 21 REEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILA 80
R AAR L P+LL+LL L A + H L+ P + + S+ A
Sbjct: 8 RSAAARALLPPMLLLLLQPPPLLARALPPDAH-----HLHAERRGPQPWHAALPSSPAPA 62
Query: 81 SALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWN 140
A E R P + ++ PRCGVPD + R R+KR+ L+G +W
Sbjct: 63 PATQEAPR----PASS---------LRPPRCGVPDPSD---GLSARNRQKRFVLSGGRWE 106
Query: 141 NHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVL 200
LT+ I + +L + + A +VW TPL F EV + ADIM+
Sbjct: 107 KTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEV--------HEGRADIMID 158
Query: 201 FASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHE 260
FA +HGD PFDG GG LAHA+FP GD HFD DE WT D G +L VA HE
Sbjct: 159 FARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTIG--DDQGTDLLQVAAHE 216
Query: 261 LGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVT 320
GH LGL+H++ A+M+ FY ++ L DD RG+Q LYG QP PTVT
Sbjct: 217 FGHVLGLQHTTAAKALMSAFYTFRYP--LSLSPDDCRGVQHLYG---------QPWPTVT 265
Query: 321 PRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAML 380
R P P+ G A PD P+ C+ FD V+ +
Sbjct: 266 SRTPALG--------------------PQAGIDTNEIAPLEPDA-PPDACEASFDAVSTI 304
Query: 381 RGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWL 440
RGE+F FK + WR+R ++ YP W+GLP + AA+E G FF+G +YW+
Sbjct: 305 RGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWV 364
Query: 441 FREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGY 500
+ G P PLT GL + + +W +FF+ YWRF+ T+R D
Sbjct: 365 YDGEKPVLG-PAPLTELGL-VRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPV 422
Query: 501 PKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQ 560
P+ + W+G+P+ AF D Y YF +G YWKFD +++ G+P+ + DF GC
Sbjct: 423 PRRATDWRGVPSEIDAAFQDAD-GYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCA 481
Query: 561 E 561
E
Sbjct: 482 E 482
>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
Length = 476
Score = 276 bits (707), Expect = 3e-74
Identities = 183/516 (35%), Positives = 253/516 (49%), Gaps = 70/516 (13%)
Query: 29 LLPLLLVLLGCLGLGVAAEDAEVH---AENWLRLYGYLPQPSRHMSTMRSAQILASALAE 85
L+ L L + L AA++ + + A+ +L Y L + + + + ++ +
Sbjct: 7 LVLLCLPVCSAYPLSGAAKEEDSNKDLAQQYLEKYYNLEKDVKQFRR-KDSNLIVKKIQG 65
Query: 86 MQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLT 145
MQ+F G+ VTG LD +T E M++PRCGVPD + KW HLT
Sbjct: 66 MQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMP-----------KWRKTHLT 114
Query: 146 FSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGF 205
+ I NYT L A+ +A +VWE+ TPL F + YE EADIM+ FA
Sbjct: 115 YRIVNYTPDLPRDAVDSAIEKALKVWEEVTPLTFSRL-YEG-------EADIMISFAVKE 166
Query: 206 HGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHAL 265
HGD FDG G LAHAY PGPGL GD HFD DE WT D G NLFLVA HELGH+L
Sbjct: 167 HGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWT---EDASGTNLFLVAAHELGHSL 223
Query: 266 GLEHSSNPNAIMAPFY-QWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRP 324
GL HS+N A+M P Y + ++ F+L +DD+ GIQ LYG
Sbjct: 224 GLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYG-------------------- 263
Query: 325 GRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEM 384
PP E P P V P +E P + P + FD ++ LRGE
Sbjct: 264 --------------PPPASTEEPLVPTKSV-PSGSEMPAKCDPAL---SFDAISTLRGEY 305
Query: 385 FVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVF-FKGDRYWLFRE 443
FK R+FWR H + + I FW LP + AAYE VF FKG+ +W R
Sbjct: 306 LFFKDRYFWRRSHWNPEPEFHL-ISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRG 364
Query: 444 ANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKP 503
++ GYP+ + + G +ID A+ + T+FF D+YWRF+E +Q + G+P+
Sbjct: 365 NEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRL 424
Query: 504 ISVWQGIP-ASPKGAFLSNDAAYTYFYKGTKYWKFD 538
I+ P PK + + YF+ G+ ++FD
Sbjct: 425 IA--DDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFD 458
>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
Length = 471
Score = 274 bits (701), Expect = 2e-73
Identities = 174/499 (34%), Positives = 240/499 (48%), Gaps = 78/499 (15%)
Query: 53 AENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCG 112
AE +LR Y Y P + +A + L EMQ F+G+ VTG LD+ T + MK+PRCG
Sbjct: 39 AERYLRSY-YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCG 97
Query: 113 VPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWE 172
VPD V KW+ +LT+ I NYT + +A ++AF+VW
Sbjct: 98 VPDVGEYNVFPRTL-----------KWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWS 146
Query: 173 QATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGD 232
TPL F + ++ I ADIM+ F HGD PFDG G LAHA+ PGP GGD
Sbjct: 147 DVTPLNFTRL-HDGI-------ADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGD 198
Query: 233 THFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLP 292
HFD DE WT SS G NLFLVA HE GH+LGL+HS +P A+M P Y + +F LP
Sbjct: 199 AHFDDDETWTSSSK---GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLP 255
Query: 293 EDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGP 352
+DD++GIQ LYG D P P P
Sbjct: 256 DDDVQGIQSLYGPGDEDPNPKHP------------------------------------- 278
Query: 353 PVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFW 412
+ PD+ P++ D + LRGE +FK R+FWR+ H + +D FW
Sbjct: 279 -------KTPDKCDPSL---SLDAITSLRGETMIFKDRFFWRL-HPQQVDAELFLTKSFW 327
Query: 413 RGLPGDISAAYERQDGRFVF-FKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIW 471
LP I AAYE +F F+G ++W ++ GYP+ ++ GL +I A+
Sbjct: 328 PELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVH 387
Query: 472 WEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISV-WQGIPASPKGAFLSNDAAYTYFYK 530
+E TG T F ++ WR+++ D YP+ I + GI + N Y YF+
Sbjct: 388 FEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKN--GYIYFFN 445
Query: 531 GT---KYWKFDNERLRMEP 546
G +Y + N +R+ P
Sbjct: 446 GPIQFEYSIWSNRIVRVMP 464
>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
sapiens]
Length = 469
Score = 274 bits (700), Expect = 2e-73
Identities = 179/500 (35%), Positives = 250/500 (50%), Gaps = 89/500 (17%)
Query: 54 ENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGV 113
+ +L Y L R + R++ + L +MQ F+G+ VTG D ET + MK+PRCGV
Sbjct: 35 QKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGV 94
Query: 114 PD--QFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVW 171
PD QF V + N R W HLT+ I+NYT L A+ +AF++W
Sbjct: 95 PDVAQF-VLTEGNPR------------WEQTHLTYRIENYTPDLPRADVDHAIEKAFQLW 141
Query: 172 EQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGG 231
TPL F +V + +ADIM+ F G H D+SPFDG GG LAHA+ PGPG+GG
Sbjct: 142 SNVTPLTFTKVS--------EGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGG 193
Query: 232 DTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKL 291
D HFD DE WT + NL VA HELGH+LGL HS++ A+M P Y + + +L
Sbjct: 194 DAHFDEDERWT---NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFS--GDVQL 248
Query: 292 PEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPG 351
+DD+ GIQ +YG P QP+ TP+
Sbjct: 249 AQDDIDGIQAIYGR---SQNPVQPIGPQTPK----------------------------- 276
Query: 352 PPVQPRATERPDQYGPNICDG--DFDTVAMLRGEMFVFKGRWFWRVR--HNRVLDNYPMP 407
CD FD + +RGE+ FK R++ R + V N+
Sbjct: 277 -----------------ACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNF--- 316
Query: 408 IGHFWRGLPGDISAAYERQDGRFV-FFKGDRYWLFREANLEPGYPQPL-TSYGLGIPYDR 465
I FW LP + AAYE D V FFKG++YW + N+ GYP+ + +S+G
Sbjct: 317 ISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKH 376
Query: 466 IDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPIS-VWQGIPASPKGAFLSNDAA 524
ID A+ E TG T+FF ++YWR++E + DPGYPK I+ + GI F+ +
Sbjct: 377 IDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKD--G 434
Query: 525 YTYFYKGTKYWKFDNERLRM 544
+ YF+ GT+ +KFD + R+
Sbjct: 435 FFYFFHGTRQYKFDPKTKRI 454
>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
Length = 403
Score = 266 bits (679), Expect = 6e-71
Identities = 173/468 (36%), Positives = 237/468 (50%), Gaps = 89/468 (19%)
Query: 86 MQRFYGIPVTGVLDEETKEWMKRPRCGVPD--QFGVRVKANLRRRRKRYALTGRKWNNHH 143
MQ F+G+ VTG D ET + MK+PRCGVPD QF V + N R W H
Sbjct: 1 MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQF-VLTEGNPR------------WEQTH 47
Query: 144 LTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFAS 203
LT+ I+NYT L A+ +AF++W TPL F +V + +ADIM+ F
Sbjct: 48 LTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVS--------EGQADIMISFVR 99
Query: 204 GFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGH 263
G H D+SPFDG GG LAHA+ PGPG+GGD HFD DE WT + NL VA HELGH
Sbjct: 100 GDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT---NNFREYNLHRVAAHELGH 156
Query: 264 ALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRR 323
+LGL HS++ A+M P Y + + +L +DD+ GIQ +YG P QP+ TP+
Sbjct: 157 SLGLSHSTDIGALMYPSYTFS--GDVQLAQDDIDGIQAIYGR---SQNPVQPIGPQTPK- 210
Query: 324 PGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDG--DFDTVAMLR 381
CD FD + +R
Sbjct: 211 ---------------------------------------------ACDSKLTFDAITTIR 225
Query: 382 GEMFVFKGRWFWRVR--HNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFV-FFKGDRY 438
GE+ FK R++ R + V N+ I FW LP + AAYE D V FFKG++Y
Sbjct: 226 GEVMFFKDRFYMRTNPFYPEVELNF---ISVFWPQLPNGLEAAYEFADRDEVRFFKGNKY 282
Query: 439 WLFREANLEPGYPQPL-TSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGD 497
W + N+ GYP+ + +S+G ID A+ E TG T+FF ++YWR++E + D
Sbjct: 283 WAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMD 342
Query: 498 PGYPKPIS-VWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRM 544
PGYPK I+ + GI F+ + + YF+ GT+ +KFD + R+
Sbjct: 343 PGYPKMIAHDFPGIGHKVDAVFMKD--GFFYFFHGTRQYKFDPKTKRI 388
>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
Length = 513
Score = 261 bits (667), Expect = 1e-69
Identities = 170/492 (34%), Positives = 235/492 (47%), Gaps = 83/492 (16%)
Query: 53 AENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCG 112
A+ +L + L H+ ++ ++ + EMQ F+G+ VTG LD T E MK PRCG
Sbjct: 33 AQAYLNQFYSLEIEGNHLVQSKNRSLIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCG 92
Query: 113 VPD--QFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRV 170
VPD Q+G Y L G W ++LT+ I NYT + EA++ V
Sbjct: 93 VPDVGQYG-------------YTLPG--WRKYNLTYRIINYTPDMARAAVDEAIQEGLEV 137
Query: 171 WEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSP-FDGTGGFLAHAYFPGPGL 229
W + TPL F ++ + ADIM+ F + HG FDG G L HA+ PGPGL
Sbjct: 138 WSKVTPLKFTKIS--------KGIADIMIAFRTRVHGRCPRYFDGPLGVLGHAFPPGPGL 189
Query: 230 GGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNF 289
GGDTHFD DE WT D G NLFLVA HE GHALGL HS++ A+M P Y D +
Sbjct: 190 GGDTHFDEDENWT---KDGAGFNLFLVAAHEFGHALGLSHSNDQTALMFPNYVSLDPRKY 246
Query: 290 KLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPK 349
L +DD+ GIQ +Y GG P+ P K
Sbjct: 247 PLSQDDINGIQSIY-------------------------------------GGLPKEPAK 269
Query: 350 PGPPVQPRATERPDQYGPNICDGD--FDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMP 407
P P P A CD D FD + R E+ FKGR WR+ ++ + D
Sbjct: 270 PKEPTIPHA-----------CDPDLTFDAITTFRREVMFFKGRHLWRIYYD-ITDVEFEL 317
Query: 408 IGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRID 467
I FW LP D+ AAYE + + FK + +W+ R + P YP+ + + G +ID
Sbjct: 318 IASFWPSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDYPKSIHTLGFPGRVKKID 377
Query: 468 TAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYP-KPISVWQGIPASPKGAFLSNDAAYT 526
A+ + T T+FF WRF+E TQ D G+P + + + GI AF +
Sbjct: 378 AAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAF--QYKGFF 435
Query: 527 YFYKGTKYWKFD 538
+F +G+K +++D
Sbjct: 436 FFSRGSKQFEYD 447
>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
sapiens]
Length = 483
Score = 258 bits (660), Expect = 1e-68
Identities = 163/472 (34%), Positives = 228/472 (48%), Gaps = 70/472 (14%)
Query: 74 RSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYA 133
R + + + E+Q F+G+ VTG LD+ T +K+PRCGVPD R+
Sbjct: 63 RGSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPG--------- 113
Query: 134 LTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQK 193
KW + LT+ I YT + +AV A + W A PL F +
Sbjct: 114 --EPKWKKNTLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRI--------NSG 163
Query: 194 EADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNL 253
EADIM+ F +G HGDS PFDG G LAHA+ PG GLGGDTHFD E WT + +G NL
Sbjct: 164 EADIMISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGT---NGFNL 220
Query: 254 FLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPT 313
F VA HE GHALGL HS++P+A+M P Y++K+ F LP+DD++GIQ LYG
Sbjct: 221 FTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYG--------P 272
Query: 314 QPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICD-- 371
+ + P P P H+P P++CD
Sbjct: 273 RKVFLGKPTLPHAPHHKPSI---------------------------------PDLCDSS 299
Query: 372 GDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYE-RQDGRF 430
FD V ML E+ +FK R FWR + + P I + L ++ AAYE + G
Sbjct: 300 SSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTA 359
Query: 431 VFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFN 490
FFKG YW+ R ++ G P+ + +G +ID A++ T FF D Y+ ++
Sbjct: 360 YFFKGPHYWITRGFQMQ-GPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYD 418
Query: 491 EETQRGDPGYPKPI-SVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNER 541
E ++ + YPK + G+ A N Y YF+ G K +K+D E+
Sbjct: 419 ERKRKMEKDYPKNTEEEFSGVNGQIDAAVELN--GYIYFFSGPKTYKYDTEK 468
>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
[Homo sapiens]
Length = 508
Score = 250 bits (639), Expect = 3e-66
Identities = 180/530 (33%), Positives = 251/530 (47%), Gaps = 98/530 (18%)
Query: 49 AEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKR 108
AEV ++L YGYL +P + + I AL Q +PV+G LD+ T+ M++
Sbjct: 24 AEVAPVDYLSQYGYLQKPLEGSNNFKPEDI-TEALRAFQEASELPVSGQLDDATRARMRQ 82
Query: 109 PRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAF 168
PRCG+ D F ++ +Y L GR W HLTF I N L + + A+R+AF
Sbjct: 83 PRCGLEDPFN--------QKTLKYLLLGR-WRKKHLTFRILNLPSTLPPHTARAALRQAF 133
Query: 169 RVWEQATPLVFQEVPY--EDIRLRRQKEADIMVLFASGFHGD-----SSPFDGTGGFLAH 221
+ W PL FQEV DIRL FHG S+ FDG G LAH
Sbjct: 134 QDWSNVAPLTFQEVQAGAADIRL--------------SFHGRQSSYCSNTFDGPGRVLAH 179
Query: 222 AYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFY 281
A P G HFD DE WT + G NL ++A HE+GHALGL HS A+MAP Y
Sbjct: 180 ADIPELG---SVHFDEDEFWTEGT--YRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVY 234
Query: 282 QWKDVDNFKLPEDDLRGIQQLYGTP-----DGQPQPTQPLPTVTPRRPGRPDHRPPRPPQ 336
+ +FKL DD+ GIQ LYG D + + T+ LPTV PP P +
Sbjct: 235 EGYR-PHFKLHPDDVAGIQALYGKKSPVIRDEEEEETE-LPTV-----------PPVPTE 281
Query: 337 PPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAM-LRGEMFVFKGRWFWRV 395
P P P+ C + D + + RG+ + FKG + W V
Sbjct: 282 PSPM--------------------------PDPCSSELDAMMLGPRGKTYAFKGDYVWTV 315
Query: 396 RHNRVLDNYPMP---IGHFWRGLPGDISAA-YERQDGRFVFFKGDRYWLFREANLEPGYP 451
D+ P P + W GLPG++ AA Y + FFKGD+ W + + PG+P
Sbjct: 316 S-----DSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFP 370
Query: 452 QPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPI-SVWQGI 510
+ L +D A++W F F+ YW+++E + YPKPI ++ G+
Sbjct: 371 KKLNRV-----EPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGV 425
Query: 511 PASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQ 560
P P A D YF+KG YW+ N++LR+E GYP++I ++M C+
Sbjct: 426 PNQPSAAMSWQDGR-VYFFKGKVYWRL-NQQLRVEKGYPRNISHNWMHCR 473
Score = 57.4 bits (137), Expect = 4e-08
Identities = 34/92 (36%), Positives = 47/92 (51%), Gaps = 3/92 (3%)
Query: 380 LRGEMFVFKGR--WFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDR 437
L ++F+FKG W W +YP PI + G+P SAA QDGR FFKG
Sbjct: 388 LNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKV 447
Query: 438 YW-LFREANLEPGYPQPLTSYGLGIPYDRIDT 468
YW L ++ +E GYP+ ++ + IDT
Sbjct: 448 YWRLNQQLRVEKGYPRNISHNWMHCRPRTIDT 479
Score = 47.4 bits (111), Expect = 4e-05
Identities = 36/144 (25%), Positives = 59/144 (40%), Gaps = 8/144 (5%)
Query: 428 GRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYW 487
G+ FKGD W ++ PG +++ G+P +D A++ T FF+ D+ W
Sbjct: 302 GKTYAFKGDYVWTVSDSG--PGPLFRVSALWEGLP-GNLDAAVYSPRTQWIHFFKGDKVW 358
Query: 488 RFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPG 547
R+ PG+PK ++ + + A + +KG+ YW++D
Sbjct: 359 RYINFKM--SPGFPKKLN---RVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSS 413
Query: 548 YPKSILRDFMGCQEHVEPGPRWPD 571
YPK I F G W D
Sbjct: 414 YPKPIKGLFTGVPNQPSAAMSWQD 437
>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
[Homo sapiens]
Length = 520
Score = 236 bits (603), Expect = 4e-62
Identities = 182/551 (33%), Positives = 245/551 (44%), Gaps = 69/551 (12%)
Query: 29 LLPLLLVLLGCLGLGVA---AEDAEVHAENWLRLYGYLPQ--PSRHMSTMRSAQILASAL 83
L L L+L G L A ++ AE +L YGYL + P ST S A+
Sbjct: 9 LRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFS-----DAI 63
Query: 84 AEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANL-----------RRRRKRY 132
Q +PV+GVLD T M RPRCGV D A RR+KR+
Sbjct: 64 RAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRF 123
Query: 133 ALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQ 192
A G KW HL++ + N+ E L AVR AF++W + L F E P
Sbjct: 124 AKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATG------ 177
Query: 193 KEADIMVLFASGFHGDS--SPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHG 250
ADI + F G H D + FDG GG LAHA+ P G + HFD DE W+ S G
Sbjct: 178 -PADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRG---EAHFDQDERWSLSRR--RG 231
Query: 251 NNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQP 310
NLF+V HE+GH LGL HS P A+MAP+Y+ D L DD+ +Q LYG P G
Sbjct: 232 RNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDAL-LSWDDVLAVQSLYGKPLG-- 288
Query: 311 QPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNIC 370
+V + PG+ P G RP+ GP C
Sbjct: 289 ------GSVAVQLPGKLFTDFETWDSYSPQG------------------RRPETQGPKYC 324
Query: 371 DGDFDTVAMLR-GEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDI-SAAYERQDG 428
FD + + R ++++FKG FW V + + P P+ W GLP +I +AA DG
Sbjct: 325 HSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSE-PRPLQERWVGLPPNIEAAAVSLNDG 383
Query: 429 RFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWR 488
F FFKG R W FR G PQ + GL D A+++ P F+ RY+
Sbjct: 384 DFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLP---RHPDAALFFPPLRRLILFKGARYYV 440
Query: 489 FNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGY 548
+ +P YP+ + W GIP GA D + F++ +YW+ D +L+
Sbjct: 441 LARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGS-IIFFRDDRYWRLDQAKLQATTSG 499
Query: 549 PKSILRDFMGC 559
+ +MGC
Sbjct: 500 RWATELPWMGC 510
>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
Length = 610
Score = 204 bits (518), Expect = 3e-52
Identities = 119/330 (36%), Positives = 163/330 (49%), Gaps = 53/330 (16%)
Query: 234 HFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPE 293
++D D W F G +LFLVA HE GHA+GLEHS +P A+MAP Y + NF+L +
Sbjct: 330 NYDDDRKWGFCPDQ--GYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQ 385
Query: 294 DDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPP 353
DD++GIQ+LYG T P PT+ P
Sbjct: 386 DDIKGIQELYGASPDIDLGTGPTPTLGP-------------------------------- 413
Query: 354 VQPRATERPDQYGPNICDGD--FDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHF 411
P IC D FD +A +RGE+F FK R+ WR R P+ + F
Sbjct: 414 -----------VTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATF 462
Query: 412 WRGLPGDISAAYER-QDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAI 470
W LP I A YE Q+ + VFF G+ YW++ + LE GYP+PLTS GL R+D A
Sbjct: 463 WPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAF 522
Query: 471 WWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPIS-VWQGIPASPKGAFLSNDAAYTYFY 529
W T+ F D++WR+NE ++ DPG+PK I+ W IP + ++YF+
Sbjct: 523 NWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFF 582
Query: 530 KGTKYWKFDNERLRMEPGYPKSILRDFMGC 559
KG Y K +N+ L+ SI D++GC
Sbjct: 583 KGAYYLKLENQSLKSVKF--GSIKSDWLGC 610
Score = 128 bits (321), Expect = 2e-29
Identities = 70/165 (42%), Positives = 90/165 (54%), Gaps = 19/165 (11%)
Query: 78 ILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGR 137
+L L +MQ+F+G+P TG LD+ T E M++PRCG PD N R+
Sbjct: 19 VLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDV----ANYNFFPRKP------- 67
Query: 138 KWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADI 197
KW+ + +T+ I YT L +A RAF+VW TPL F + EADI
Sbjct: 68 KWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRI--------HDGEADI 119
Query: 198 MVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWT 242
M+ F HGD PFDG G LAHA+ PG G+GGD+HFD DE WT
Sbjct: 120 MINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 164
>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
[Homo sapiens]
Length = 660
Score = 204 bits (518), Expect = 3e-52
Identities = 119/330 (36%), Positives = 163/330 (49%), Gaps = 53/330 (16%)
Query: 234 HFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPE 293
++D D W F G +LFLVA HE GHA+GLEHS +P A+MAP Y + NF+L +
Sbjct: 380 NYDDDRKWGFCPDQ--GYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTY--TKNFRLSQ 435
Query: 294 DDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPP 353
DD++GIQ+LYG T P PT+ P
Sbjct: 436 DDIKGIQELYGASPDIDLGTGPTPTLGP-------------------------------- 463
Query: 354 VQPRATERPDQYGPNICDGD--FDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHF 411
P IC D FD +A +RGE+F FK R+ WR R P+ + F
Sbjct: 464 -----------VTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATF 512
Query: 412 WRGLPGDISAAYER-QDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAI 470
W LP I A YE Q+ + VFF G+ YW++ + LE GYP+PLTS GL R+D A
Sbjct: 513 WPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAF 572
Query: 471 WWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPIS-VWQGIPASPKGAFLSNDAAYTYFY 529
W T+ F D++WR+NE ++ DPG+PK I+ W IP + ++YF+
Sbjct: 573 NWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFF 632
Query: 530 KGTKYWKFDNERLRMEPGYPKSILRDFMGC 559
KG Y K +N+ L+ SI D++GC
Sbjct: 633 KGAYYLKLENQSLKSVKF--GSIKSDWLGC 660
Score = 128 bits (321), Expect = 2e-29
Identities = 70/165 (42%), Positives = 90/165 (54%), Gaps = 19/165 (11%)
Query: 78 ILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGR 137
+L L +MQ+F+G+P TG LD+ T E M++PRCG PD N R+
Sbjct: 69 VLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDV----ANYNFFPRKP------- 117
Query: 138 KWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADI 197
KW+ + +T+ I YT L +A RAF+VW TPL F + EADI
Sbjct: 118 KWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRI--------HDGEADI 169
Query: 198 MVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWT 242
M+ F HGD PFDG G LAHA+ PG G+GGD+HFD DE WT
Sbjct: 170 MINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 214
>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
Length = 267
Score = 197 bits (502), Expect = 2e-50
Identities = 114/279 (40%), Positives = 155/279 (55%), Gaps = 21/279 (7%)
Query: 26 RPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAE 85
R +L + +L G L L + E + W + YL + + S ++A L + L E
Sbjct: 2 RLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKE 61
Query: 86 MQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLT 145
MQ+F+G+P+TG+L+ E M++PRCGVPD + N KW + +T
Sbjct: 62 MQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPN-----------SPKWTSKVVT 110
Query: 146 FSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGF 205
+ I +YT L V +A +W + PL F++V + ADIM+ FA G
Sbjct: 111 YRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGT--------ADIMIGFARGA 162
Query: 206 HGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHAL 265
HGDS PFDG G LAHA+ PG GLGGD HFD DE WT S+ G N A HELGH+L
Sbjct: 163 HGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSS--LGINFLYAATHELGHSL 220
Query: 266 GLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYG 304
G+ HSS+PNA+M P Y D NFKL +DD++GIQ+LYG
Sbjct: 221 GMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYG 259
>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
sapiens]
Length = 261
Score = 151 bits (382), Expect = 2e-36
Identities = 86/211 (40%), Positives = 111/211 (52%), Gaps = 24/211 (11%)
Query: 95 TGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGR-KWNNHHLTFSIQNYTE 153
T +LD + + +P CGVPD + GR KWN H LT+ I NY
Sbjct: 66 TDLLDMQMHALLHQPHCGVPDGSDTSISP------------GRCKWNKHTLTYRIINYPH 113
Query: 154 KLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFD 213
+ +++ A +W TPL+FQ+V D ADI V F H D PFD
Sbjct: 114 DMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGD--------ADIKVSFWQWAHEDGWPFD 165
Query: 214 GTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNP 273
G GG L HA+ P G G HFD +E W+ S T G NLFLVA HE+GH+LGL+HS N
Sbjct: 166 GPGGILGHAFLPNSGNPGVVHFDKNEHWSASDT---GYNLFLVATHEIGHSLGLQHSGNQ 222
Query: 274 NAIMAPFYQWKDVDNFKLPEDDLRGIQQLYG 304
++IM P Y + D F+L DD++ IQ LYG
Sbjct: 223 SSIMYPTYWYHDPRTFQLSADDIQRIQHLYG 253
>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
Length = 707
Score = 141 bits (356), Expect = 2e-33
Identities = 106/343 (30%), Positives = 155/343 (45%), Gaps = 27/343 (7%)
Query: 233 THFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLP 292
++FD+D+ W F G +LFLVA HE GHALGL+HSS P A+M P Y++ + L
Sbjct: 377 SNFDSDKKWGFCPDQ--GYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRF--TEGPPLH 432
Query: 293 EDDLRGIQQLYG-TPDGQ--------PQPTQPLPTVTPRRPG--RPDHRPPRPPQPPPPG 341
+DD+ GI+ LYG P+ + PQPT P PTV P P P RP P PP
Sbjct: 433 KDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAP-PTVCPTGPPTVHPSERPTAGPTGPPSA 491
Query: 342 GKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNR-V 400
G P PP GP P N+ FD +A + ++++FK +WR R
Sbjct: 492 G-PTGPPTAGPSTATTVPLSPVDDACNV--NIFDAIAEIGNQLYLFKDGKYWRFSEGRGS 548
Query: 401 LDNYPMPIGHFWRGLPGDISAAY-ERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGL 459
P I W LP + + + ER + FF G + W++ A++ P+ L GL
Sbjct: 549 RPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLG--PRRLDKLGL 606
Query: 460 GIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPIS-VWQGIPASPKGAF 518
G ++ A+ G F R WRF+ + Q DP + ++ G+P F
Sbjct: 607 GADVAQVTGAL-RSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVF 665
Query: 519 LSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQE 561
+ A YF + YW+ + + + D + C E
Sbjct: 666 QYREKA--YFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPE 706
Score = 125 bits (313), Expect = 2e-28
Identities = 74/190 (38%), Positives = 99/190 (52%), Gaps = 23/190 (12%)
Query: 53 AENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCG 112
AE +L YGY +R ++ L AL +Q+ +P TG LD T + M+ PRCG
Sbjct: 45 AEEYLYRYGY----TRVAEMRGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCG 100
Query: 113 VPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWE 172
VPD R + KW++H++T+ IQNY+E L +A RAF +W
Sbjct: 101 VPDL-----------GRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWS 149
Query: 173 QATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGD 232
TPL F V ++ADI++ F HGD PFDG G LAHA+ PGPG+ GD
Sbjct: 150 AVTPLTFTRV--------YSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGD 201
Query: 233 THFDADEPWT 242
HFD DE W+
Sbjct: 202 AHFDDDELWS 211
>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
sapiens]
Length = 569
Score = 107 bits (267), Expect = 4e-23
Identities = 102/297 (34%), Positives = 137/297 (46%), Gaps = 50/297 (16%)
Query: 49 AEVHA-ENWLRLYGYL-------PQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDE 100
A++HA + +L YG+ P P T + A LA A+ QR +P +G LD
Sbjct: 48 ADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAA-LAEAVRRFQRANALPASGELDA 106
Query: 101 ETKEWMKRPRCGVPDQF-----------GVRVKANLRRR-RKRYALTGRKWNNH------ 142
T M RPRCGVPD G +A RR R +L+ R W
Sbjct: 107 ATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGG 166
Query: 143 ------HLTFSIQNYTEKLGWYHSMEAVRR----AFRVWEQATPLVFQEVPYEDIRLRRQ 192
T S + E L S+ RR AFR+W + TPL F+ ED+
Sbjct: 167 AAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFR----EDL-AAPG 221
Query: 193 KEADIMVLFASGFH-GDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGN 251
DI + F G H G FDG+G AHA+ GD HFD DE +T ++D G
Sbjct: 222 AAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAW-----RLGDIHFDDDEHFTPPTSDT-GI 275
Query: 252 NLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDG 308
+L VAVHE+GH LGL H+ +IM P Y ++ F+L D + IQ+LYG+ +G
Sbjct: 276 SLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQE-PAFELDWSDRKAIQKLYGSCEG 331
Score = 66.6 bits (161), Expect = 7e-11
Identities = 60/238 (25%), Positives = 98/238 (41%), Gaps = 46/238 (19%)
Query: 370 CDGDFDTV-------------AMLRGEMFVFKGRWFWRV--RHNRVLDNYPMPIGHFWRG 414
C+G FDT M+R + F+ W+W R+NR P+ I W G
Sbjct: 329 CEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPG 388
Query: 415 LPGDISAAYE-----RQDGRFVFFKGDRYWLF--------REANLEPGYPQPLTSYGLGI 461
+P A+ ++D R+ FF+G++YW + E YP+ ++ GI
Sbjct: 389 IPTHNIDAFVHIWTWKRDERY-FFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGI 447
Query: 462 PYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSN 521
P +DTA + +FF+E + F+ R YPK I+ F +
Sbjct: 448 P-SPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNI 506
Query: 522 DAAY-------TYFYKGTKYWKFDNERLRMEPG-------YPKSILRD--FMGCQEHV 563
D+AY +F+KG YWK N++ + + +PK + + F C H+
Sbjct: 507 DSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKKFISEKWFDVCDVHI 564
Score = 35.4 bits (80), Expect = 0.17
Identities = 21/66 (31%), Positives = 25/66 (37%)
Query: 296 LRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQ 355
+R Q+ P L + R G PD RPP P PP P G P R P
Sbjct: 89 VRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRA 148
Query: 356 PRATER 361
P + R
Sbjct: 149 PLSLSR 154
>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
Length = 390
Score = 90.5 bits (223), Expect = 4e-18
Identities = 71/206 (34%), Positives = 97/206 (47%), Gaps = 33/206 (16%)
Query: 120 RVKANLRRRRKRYALTGRK--WNNHHLTFSIQNYTEKL-GWYHSMEAVRRAFRVWEQATP 176
RV L RR+RY LT + W++ +LT+ I ++ L + A+ AFR+W +P
Sbjct: 67 RVPGPLAPRRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSP 126
Query: 177 LVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSP------FDGTGGFLAHAYFPGPGLG 230
F+EV E + +D+ + F H D FDG G LAHA+FP G
Sbjct: 127 FSFREVAPE-------QPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHG-- 177
Query: 231 GDTHFDADEPWTFSSTDLHGN------NLFLVAVHELGHALGLEHSSNPNAIM---APFY 281
HFD E W T +L VA HE+GHALGL HS + A+M A
Sbjct: 178 -GIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLR 236
Query: 282 QWKDVDNFKLPEDDLRGIQQLYGTPD 307
WK L +D+L G+ +LYG D
Sbjct: 237 GWK-----ALSQDELWGLHRLYGCLD 257
>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
sapiens]
Length = 183
Score = 84.0 bits (206), Expect = 4e-16
Identities = 61/175 (34%), Positives = 82/175 (46%), Gaps = 31/175 (17%)
Query: 49 AEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKR 108
AEV ++L YGYL +P + + I AL Q +PV+G LD+ T+ M++
Sbjct: 24 AEVAPVDYLSQYGYLQKPLEGSNNFKPEDI-TEALRAFQEASELPVSGQLDDATRARMRQ 82
Query: 109 PRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAF 168
PRCG+ D F ++ +Y L GR W HLTF I N L + + A+R+AF
Sbjct: 83 PRCGLEDPFN--------QKTLKYLLLGR-WRKKHLTFRILNLPSTLPPHTARAALRQAF 133
Query: 169 RVWEQATPLVFQEVP--YEDIRLRRQKEADIMVLFASGFHGD-----SSPFDGTG 216
+ W PL FQEV DIRL FHG S+ FDG G
Sbjct: 134 QDWSNVAPLTFQEVQAGAADIRL--------------SFHGRQSSYCSNTFDGPG 174
>gi|88853069 vitronectin precursor [Homo sapiens]
Length = 478
Score = 76.6 bits (187), Expect = 7e-14
Identities = 56/199 (28%), Positives = 88/199 (44%), Gaps = 33/199 (16%)
Query: 305 TPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQ 364
TP +P+ P P V +P D RP + P +P PP +
Sbjct: 113 TPVLKPEEEAPAPEVGASKPEGIDSRP-----------ETLHPGRPQPPAEEE------- 154
Query: 365 YGPNICDGD-FDTVAMLR-GEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAA 422
+C G FD L+ G +F F+G++ + + V YP I W G+ G I AA
Sbjct: 155 ----LCSGKPFDAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVW-GIEGPIDAA 209
Query: 423 YERQD--GRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAI-----WWEPT 475
+ R + G+ FKG +YW F + L+P YP+ ++ GIP D +D A+ +
Sbjct: 210 FTRINCQGKTYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIP-DNVDAALALPAHSYSGR 268
Query: 476 GHTFFFQEDRYWRFNEETQ 494
+FF+ +YW + + Q
Sbjct: 269 ERVYFFKGKQYWEYQFQHQ 287
Score = 56.6 bits (135), Expect = 7e-08
Identities = 42/126 (33%), Positives = 59/126 (46%), Gaps = 11/126 (8%)
Query: 442 REANLEPGYPQPLTSYGL--GIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPG 499
R L PG PQP L G P+D G F F+ + +E+ R PG
Sbjct: 138 RPETLHPGRPQPPAEEELCSGKPFDAFTDL----KNGSLFAFRGQYCYELDEKAVR--PG 191
Query: 500 YPKPISVWQGIPASPKGAFLS-NDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMG 558
YPK I GI AF N TY +KG++YW+F++ L +P YP++I F G
Sbjct: 192 YPKLIRDVWGIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGVL--DPDYPRNISDGFDG 249
Query: 559 CQEHVE 564
++V+
Sbjct: 250 IPDNVD 255
Score = 56.2 bits (134), Expect = 9e-08
Identities = 41/131 (31%), Positives = 65/131 (49%), Gaps = 13/131 (9%)
Query: 414 GLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTS-YGLGIPYDRIDTAIWW 472
G P D A + ++G F+G + E + PGYP+ + +G+ P D T I
Sbjct: 158 GKPFD--AFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVWGIEGPIDAAFTRINC 215
Query: 473 EPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISV-WQGIPASPKGAFLSNDAAYT----- 526
+ G T+ F+ +YWRF + DP YP+ IS + GIP + A +Y+
Sbjct: 216 Q--GKTYLFKGSQYWRFEDGVL--DPDYPRNISDGFDGIPDNVDAALALPAHSYSGRERV 271
Query: 527 YFYKGTKYWKF 537
YF+KG +YW++
Sbjct: 272 YFFKGKQYWEY 282
Score = 37.4 bits (85), Expect = 0.045
Identities = 20/44 (45%), Positives = 25/44 (56%), Gaps = 4/44 (9%)
Query: 473 EPTGHTFFFQEDRYWRFNEETQR---GDPGYPKPIS-VWQGIPA 512
EP FFF D+Y+R N T+R DP YP+ I+ W G PA
Sbjct: 431 EPIQSVFFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGCPA 474
Score = 29.6 bits (65), Expect = 9.4
Identities = 12/36 (33%), Positives = 23/36 (63%), Gaps = 3/36 (8%)
Query: 527 YFYKGTKYWKFDNERLRME---PGYPKSILRDFMGC 559
+F+ G KY++ + R++ P YP+SI + ++GC
Sbjct: 437 FFFSGDKYYRVNLRTRRVDTVDPPYPRSIAQYWLGC 472
>gi|11321561 hemopexin precursor [Homo sapiens]
Length = 462
Score = 64.7 bits (156), Expect = 3e-10
Identities = 63/233 (27%), Positives = 91/233 (39%), Gaps = 34/233 (14%)
Query: 335 PQPPPP--GGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAML-RGEMFVFKGRW 391
P PP G E KP P V R ++ FD + G M FKG +
Sbjct: 25 PLPPTSAHGNVAEGETKPDPDVTERCSD----------GWSFDATTLDDNGTMLFFKGEF 74
Query: 392 FWRV-RHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGY 450
W+ + +R L I W+ P + AA+ + KGD+ W++ E GY
Sbjct: 75 VWKSHKWDREL------ISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGY 128
Query: 451 PQPLTSYGLGIPYDRIDTAIWWE----PTGHTFFFQEDRYWRFNEETQRGDPGYPKPISV 506
P+ L GIP +D A+ FFQ DR W ++ T G K S
Sbjct: 129 PKLLQDEFPGIP-SPLDAAVECHRGECQAEGVLFFQGDREWFWDLAT-----GTMKERS- 181
Query: 507 WQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGC 559
W PA + Y ++G ++ +FD R + P YP+ + FM C
Sbjct: 182 W---PAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPC 231
>gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]
Length = 198
Score = 64.3 bits (155), Expect = 3e-10
Identities = 39/96 (40%), Positives = 51/96 (53%), Gaps = 11/96 (11%)
Query: 149 QNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMV--LFASGFH 206
QNY L A +AF +W +A+ L F + E DI++ +F + H
Sbjct: 27 QNYMPNLPQEDVDRATGKAFELWSKASALTFTR--------DFESEGDIILSFVFLADLH 78
Query: 207 GDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWT 242
D+SPF G G LAHA+ PGPG+GGD HFD DE T
Sbjct: 79 -DNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRT 113
Score = 63.2 bits (152), Expect = 8e-10
Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 3/98 (3%)
Query: 414 GLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPL-TSYGLGIPYDRIDTAIWW 472
G+ GD+ ++ + R F+ ++W+ +E L GYP+ + +S+ +ID AI+
Sbjct: 99 GIGGDVH--FDNDETRTKDFRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYE 156
Query: 473 EPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGI 510
+ TG T FF + YWR++E Q D GYPK I GI
Sbjct: 157 KDTGKTHFFVANEYWRYDENMQSVDAGYPKIIDDLPGI 194
Score = 38.5 bits (88), Expect = 0.020
Identities = 20/75 (26%), Positives = 33/75 (44%), Gaps = 5/75 (6%)
Query: 481 FQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPK---GAFLSNDAAYTYFYKGTKYWKF 537
F+ ++W E+ GYP+ + P K A D T+F+ +YW++
Sbjct: 116 FRSSKHWVVQEDQLLS--GYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRY 173
Query: 538 DNERLRMEPGYPKSI 552
D ++ GYPK I
Sbjct: 174 DENMQSVDAGYPKII 188
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.141 0.467
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,648,437
Number of Sequences: 37866
Number of extensions: 2222420
Number of successful extensions: 34494
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 616
Number of HSP's successfully gapped in prelim test: 661
Number of HSP's that attempted gapping in prelim test: 15182
Number of HSP's gapped (non-prelim): 11458
length of query: 669
length of database: 18,247,518
effective HSP length: 109
effective length of query: 560
effective length of database: 14,120,124
effective search space: 7907269440
effective search space used: 7907269440
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.