Search of human proteins with 4505209

Search of human proteins with 4505209

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505209 matrix metalloproteinase 13 preproprotein [Homo
sapiens]
         (471 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]   997   0.0  
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]    490   e-138
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]   480   e-135
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]    477   e-134
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...   458   e-129
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                441   e-124
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]      439   e-123
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...   425   e-119
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...   417   e-116
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...   303   2e-82
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]   294   1e-79
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]   293   3e-79
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]   274   1e-73
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...   245   7e-65
gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]    243   4e-64
gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein...   239   3e-63
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...   232   6e-61
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...   225   6e-59
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]      223   3e-58
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...   223   3e-58
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...   216   4e-56
gi|73808266 matrix metalloproteinase 26 preproprotein [Homo sapi...   196   3e-50
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...   193   3e-49
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]   180   2e-45
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...   126   4e-29
gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]      101   1e-21
gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]           91   3e-18
gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]           89   7e-18
gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]           89   1e-17
gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo ...    77   3e-14

>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score =  997 bits (2577), Expect = 0.0
 Identities = 471/471 (100%), Positives = 471/471 (100%)

Query: 1   MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA 60
           MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA
Sbjct: 1   MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENA 60

Query: 61  ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY 120
           ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY
Sbjct: 61  ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTY 120

Query: 121 RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG 180
           RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG
Sbjct: 121 RIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDG 180

Query: 181 PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM 240
           PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM
Sbjct: 181 PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM 240

Query: 241 FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET 300
           FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET
Sbjct: 241 FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGET 300

Query: 301 MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY 360
           MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY
Sbjct: 301 MIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGY 360

Query: 361 DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI 420
           DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI
Sbjct: 361 DILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLI 420

Query: 421 EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC 471
           EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
Sbjct: 421 EEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC 471


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score =  490 bits (1261), Expect = e-138
 Identities = 236/477 (49%), Positives = 314/477 (65%), Gaps = 14/477 (2%)

Query: 6   LAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYH-PTNLAGILKENAASSM 64
           L   L L    C A PL      +D S   +   ++YL +YY    ++   ++   +  +
Sbjct: 4   LPILLLLCVAVCSAYPLDGAARGEDTS---MNLVQKYLENYYDLKKDVKQFVRRKDSGPV 60

Query: 65  TERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVN 124
            +++REMQ F GLEVTGKLD +TL+VM+KPRCGVPDVG +  FP   KW K +LTYRIVN
Sbjct: 61  VKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVN 120

Query: 125 YTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGL 184
           YTPD+    V+ A +KA KVW +VTPL F+RL++G ADIMISF ++EHGDFYPFDGP  +
Sbjct: 121 YTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNV 180

Query: 185 LAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY 244
           LAHA+ PGP   GDAHFDDDE WT  + G NLFLVAAHE GHSLGL HS +  ALM+P+Y
Sbjct: 181 LAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLY 240

Query: 245 -TYTGKSHFMLPDDDVQGIQSLYGPGDEDPN---------PKHPKTPDKCDPSLSLDAIT 294
            + T  + F L  DD+ GIQSLYGP  + P          P  P TP  CDP+LS DA++
Sbjct: 241 HSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVS 300

Query: 295 SLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKF 354
           +LRGE +IFKDR FWR   ++++ EL L  SFWP LP+ +DAAYE  S DL+FIF+G +F
Sbjct: 301 TLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQF 360

Query: 355 WALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDK 414
           WA+ G ++  GYP+ I  LG P  V+KI AA+  ++  KT  F  ++ WR+D+  + M+ 
Sbjct: 361 WAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEP 420

Query: 415 DYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC 471
            +P+ I EDFPGI  K+DAV+E+ G+ YFF G  Q E+   + ++   + +NS L C
Sbjct: 421 GFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC 477


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score =  480 bits (1235), Expect = e-135
 Identities = 237/476 (49%), Positives = 315/476 (66%), Gaps = 13/476 (2%)

Query: 6   LAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMT 65
           LA  + L    C A PL     E+D S +DL  A++YL  YY+        +   ++ + 
Sbjct: 4   LAFLVLLCLPVCSAYPLSGAAKEED-SNKDL--AQQYLEKYYNLEKDVKQFRRKDSNLIV 60

Query: 66  ERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNY 125
           ++++ MQ F GLEVTGKLD +TL+VM+KPRCGVPDVG ++ FP   KW K +LTYRIVNY
Sbjct: 61  KKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGVPDVGHFSSFPGMPKWRKTHLTYRIVNY 120

Query: 126 TPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLL 185
           TPD+    V+ A +KA KVW +VTPL F+RL++G ADIMISF +KEHGDFY FDGP   L
Sbjct: 121 TPDLPRDAVDSAIEKALKVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSL 180

Query: 186 AHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY- 244
           AHA+PPGP   GD HFDDDE WT  + G NLFLVAAHE GHSLGL HS +  ALM+P+Y 
Sbjct: 181 AHAYPPGPGLYGDIHFDDDEKWTEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYN 240

Query: 245 TYTGKSHFMLPDDDVQGIQSLYGP---GDEDP------NPKHPKTPDKCDPSLSLDAITS 295
           ++T  + F L  DDV GIQSLYGP     E+P       P   + P KCDP+LS DAI++
Sbjct: 241 SFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAIST 300

Query: 296 LRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFW 355
           LRGE + FKDR+FWR      + E  L  +FWP LP+ +DAAYE  S D +FIF+G +FW
Sbjct: 301 LRGEYLFFKDRYFWRRSHWNPEPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFW 360

Query: 356 ALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKD 415
           A+ G ++  GYP+ I  LG P  ++KI AAV  ++  KT  F+ ++ WR+D+ +  M++ 
Sbjct: 361 AIRGNEVQAGYPRGIHTLGFPPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQG 420

Query: 416 YPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC 471
           +PRLI +DFPG+  KVDAV +  G+ YFF+G  QFE+   +  +  ++ +NS L C
Sbjct: 421 FPRLIADDFPGVEPKVDAVLQAFGFFYFFSGSSQFEFDPNARMVTHILKSNSWLHC 476


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score =  477 bits (1227), Expect = e-134
 Identities = 227/440 (51%), Positives = 296/440 (67%), Gaps = 3/440 (0%)

Query: 33  EEDLQFAERYLRSYYH-PTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVM 91
           E++ +  + YL  +Y  P+N     ++N  + + E+L+EMQ FFGL VTGK ++ TLD+M
Sbjct: 27  EKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMM 86

Query: 92  KKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPL 151
           KKPRCGVPD G + + P   KW + NLTYRI NYTP ++ +EVE+A K AF++WS  +PL
Sbjct: 87  KKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPL 146

Query: 152 NFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSS 211
            FTR+  G ADI I+F  ++HGD  PFDGP+G+LAHAF PG   GGDAHFD +ETWT++S
Sbjct: 147 IFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTS 206

Query: 212 KGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDE 271
             YNLFLVAAHEFGHSLGL HS DPGALM+P Y +   S++ LP DD+ GIQ++YG    
Sbjct: 207 ANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSN 266

Query: 272 DPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELP 331
              P  P TP  CDPSL+ DAIT+LRGE + FKDR+FWR HPQ    E+     FWP LP
Sbjct: 267 PIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLP 326

Query: 332 NRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDT 391
             I AAYE    DLIF+F+G ++WAL+GYDIL+GYPK IS  G P  V+ I AAV +   
Sbjct: 327 TGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYR-- 384

Query: 392 GKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFE 451
            KT  F  +Q WRYD+    M+  YP+ I   FPGI  KVDAV+++  + + F+GP  + 
Sbjct: 385 SKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYA 444

Query: 452 YSIWSNRIVRVMPANSILWC 471
           + + + R+ RV   N  L C
Sbjct: 445 FDLIAQRVTRVARGNKWLNC 464


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score =  458 bits (1178), Expect = e-129
 Identities = 221/444 (49%), Positives = 296/444 (66%), Gaps = 4/444 (0%)

Query: 30  DLSEEDLQFAERYLRSYYHPTNLAG-ILKENAASSMTERLREMQSFFGLEVTGKLDDNTL 88
           +  E+D+   ++YL  YY+  N    + K   +  + E+L++MQ FFGL+VTGK D  TL
Sbjct: 25  ETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETL 84

Query: 89  DVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDV 148
            VMK+PRCGVPDV ++ +     +W + +LTYRI NYTPD+  ++V+ A +KAF++WS+V
Sbjct: 85  KVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNV 144

Query: 149 TPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWT 208
           TPL FT++ +G ADIMISF   +H D  PFDGP G LAHAF PGP  GGDAHFD+DE WT
Sbjct: 145 TPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWT 204

Query: 209 SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP 268
           ++ + YNL  VAAHE GHSLGL HS D GALM+P YT++G     L  DD+ GIQ++YG 
Sbjct: 205 NNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG--DVQLAQDDIDGIQAIYGR 262

Query: 269 GDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWP 328
                 P  P+TP  CD  L+ DAIT++RGE M FKDRF+ R +P   + EL     FWP
Sbjct: 263 SQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWP 322

Query: 329 ELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKI-SELGLPKEVKKISAAVH 387
           +LPN ++AAYE    D +  F+G K+WA+ G ++L GYPK I S  G P+ VK I AA+ 
Sbjct: 323 QLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALS 382

Query: 388 FEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGP 447
            E+TGKT  F  N+ WRYD+    MD  YP++I  DFPGIG KVDAV+ K+G+ YFF+G 
Sbjct: 383 EENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGT 442

Query: 448 IQFEYSIWSNRIVRVMPANSILWC 471
            Q+++   + RI+ +  ANS   C
Sbjct: 443 RQYKFDPKTKRILTLQKANSWFNC 466


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score =  441 bits (1133), Expect = e-124
 Identities = 229/472 (48%), Positives = 293/472 (62%), Gaps = 15/472 (3%)

Query: 5   VLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAG--ILKENAAS 62
           +L  FLF   T   A PL    +    +EE++Q A+ YL  +Y    + G  +++    S
Sbjct: 4   LLLLFLFFI-TFSSAFPLVRMTE----NEENMQLAQAYLNQFYS-LEIEGNHLVQSKNRS 57

Query: 63  SMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLK-WSKMNLTYR 121
            + +++REMQ+FFGL VTGKLD NTL++MK PRCGVPDVG+Y     TL  W K NLTYR
Sbjct: 58  LIDDKIREMQAFFGLTVTGKLDSNTLEIMKTPRCGVPDVGQYGY---TLPGWRKYNLTYR 114

Query: 122 IVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYP-FDG 180
           I+NYTPDM  + V++A ++  +VWS VTPL FT++  GIADIMI+F  + HG     FDG
Sbjct: 115 IINYTPDMARAAVDEAIQEGLEVWSKVTPLKFTKISKGIADIMIAFRTRVHGRCPRYFDG 174

Query: 181 PSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALM 240
           P G+L HAFPPGP  GGD HFD+DE WT    G+NLFLVAAHEFGH+LGL HS D  ALM
Sbjct: 175 PLGVLGHAFPPGPGLGGDTHFDEDENWTKDGAGFNLFLVAAHEFGHALGLSHSNDQTALM 234

Query: 241 FPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDP-NPKHPKTPDKCDPSLSLDAITSLRGE 299
           FP Y       + L  DD+ GIQS+YG   ++P  PK P  P  CDP L+ DAIT+ R E
Sbjct: 235 FPNYVSLDPRKYPLSQDDINGIQSIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRRE 294

Query: 300 TMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNG 359
            M FK R  WR++    D E  L  SFWP LP  + AAYE+P  D I +F+   FW + G
Sbjct: 295 VMFFKGRHLWRIYYDITDVEFELIASFWPSLPADLQAAYENP-RDKILVFKDENFWMIRG 353

Query: 360 YDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRL 419
           Y +L  YPK I  LG P  VKKI AAV  + T KT  F G   WR+D+    MDK +P+ 
Sbjct: 354 YAVLPDYPKSIHTLGFPGRVKKIDAAVCDKTTRKTYFFVGIWCWRFDEMTQTMDKGFPQR 413

Query: 420 IEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC 471
           + + FPGI  +VDA ++  G+ +F  G  QFEY I +  I R+M  N+   C
Sbjct: 414 VVKHFPGISIRVDAAFQYKGFFFFSRGSKQFEYDIKTKNITRIMRTNTWFQC 465


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score =  439 bits (1130), Expect = e-123
 Identities = 211/402 (52%), Positives = 274/402 (68%), Gaps = 3/402 (0%)

Query: 71  MQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMT 130
           MQ FFGL+VTGK D  TL VMK+PRCGVPDV ++ +     +W + +LTYRI NYTPD+ 
Sbjct: 1   MQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLP 60

Query: 131 HSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFP 190
            ++V+ A +KAF++WS+VTPL FT++ +G ADIMISF   +H D  PFDGP G LAHAF 
Sbjct: 61  RADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 120

Query: 191 PGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKS 250
           PGP  GGDAHFD+DE WT++ + YNL  VAAHE GHSLGL HS D GALM+P YT++G  
Sbjct: 121 PGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSG-- 178

Query: 251 HFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWR 310
              L  DD+ GIQ++YG       P  P+TP  CD  L+ DAIT++RGE M FKDRF+ R
Sbjct: 179 DVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMR 238

Query: 311 LHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKI 370
            +P   + EL     FWP+LPN ++AAYE    D +  F+G K+WA+ G ++L GYPK I
Sbjct: 239 TNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDI 298

Query: 371 -SELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGD 429
            S  G P+ VK I AA+  E+TGKT  F  N+ WRYD+    MD  YP++I  DFPGIG 
Sbjct: 299 YSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGH 358

Query: 430 KVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC 471
           KVDAV+ K+G+ YFF+G  Q+++   + RI+ +  ANS   C
Sbjct: 359 KVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNC 400


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score =  425 bits (1093), Expect = e-119
 Identities = 221/468 (47%), Positives = 290/468 (61%), Gaps = 10/468 (2%)

Query: 10  LFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYH-PTNLAGILK-ENAASSMTER 67
           L L  T   ALPL S      L + ++ F ERYL  +Y    N   + K + + + M E+
Sbjct: 7   LLLQATASGALPLNSS---TSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEK 63

Query: 68  LREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTP 127
           ++EMQ F GL+VTG+LD +TL++M  PRCGVPDV  +   P    W K  +TYRI NYTP
Sbjct: 64  IQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTP 123

Query: 128 DMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAH 187
           DM   +V+ A +KAF+VWS+VTPL F++++ G+ADI++ F    HGDF+ FDG  G+LAH
Sbjct: 124 DMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAH 183

Query: 188 AFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYT 247
           AF PG   GGDAHFD+DE WT+ S G NLFL A HE GHSLGL HS DP A+MFP Y Y 
Sbjct: 184 AFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYV 243

Query: 248 GKSHFMLPDDDVQGIQSLYGPGDED---PNPKHPKTPDKCDPSLSLDAITSLRGETMIFK 304
             + F L  DD++GIQSLYG   E+   PNP + + P  CDP+LS DA+T++  +   FK
Sbjct: 244 DINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSE-PALCDPNLSFDAVTTVGNKIFFFK 302

Query: 305 DRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILE 364
           DRFFW    ++    + L  S WP LP+ I+AAYE  + + +F+F+  K+W ++      
Sbjct: 303 DRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEP 362

Query: 365 GYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDF 424
            YPK I   G P  VKKI AAV      +T  F  NQ WRYD+   +MD  YP+LI ++F
Sbjct: 363 NYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNF 422

Query: 425 PGIGDKVDAV-YEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC 471
            GIG K+DAV Y KN Y YFF G  QFEY     RI + + +NS   C
Sbjct: 423 QGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC 470


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score =  417 bits (1071), Expect = e-116
 Identities = 209/447 (46%), Positives = 281/447 (62%), Gaps = 14/447 (3%)

Query: 37  QFAERYLRSYY--HPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKP 94
           + A+ YL  YY     +  G +    ++SM  +++E+Q+FFGL+VTGKLD  T++V+KKP
Sbjct: 39  RLAQAYLDKYYTNKEGHQIGEMVARGSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIKKP 98

Query: 95  RCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFT 154
           RCGVPDV  Y +FP   KW K  LTYRI  YTP M+  EV+KA + A + WS   PL+F 
Sbjct: 99  RCGVPDVANYRLFPGEPKWKKNTLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFV 158

Query: 155 RLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGY 214
           R++ G ADIMISF   +HGD YPFDGP G LAHAF PG   GGD HFD+ E WT  + G+
Sbjct: 159 RINSGEADIMISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTNGF 218

Query: 215 NLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGP------ 268
           NLF VAAHEFGH+LGL HS DP ALM+P Y Y     F LP DDV+GIQ+LYGP      
Sbjct: 219 NLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYGPRKVFLG 278

Query: 269 GDEDPNPKH--PKTPDKCDPSLSLDAITSLRGETMIFKDRFFWR--LHPQQVDAELFLTK 324
               P+  H  P  PD CD S S DA+T L  E ++FKDR FWR  +H +       +T 
Sbjct: 279 KPTLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIRPSTITS 338

Query: 325 SFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISA 384
           SF P+L + +DAAYE       + F+G  +W   G+  ++G P+ I + G P+ V++I A
Sbjct: 339 SF-PQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQ-MQGPPRTIYDFGFPRHVQQIDA 396

Query: 385 AVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFF 444
           AV+  +  KTL F G++ + YD+    M+KDYP+  EE+F G+  ++DA  E NGYIYFF
Sbjct: 397 AVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQIDAAVELNGYIYFF 456

Query: 445 NGPIQFEYSIWSNRIVRVMPANSILWC 471
           +GP  ++Y      +V V+ ++S + C
Sbjct: 457 SGPKTYKYDTEKEDVVSVVKSSSWIGC 483


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score =  303 bits (777), Expect = 2e-82
 Identities = 184/483 (38%), Positives = 252/483 (52%), Gaps = 65/483 (13%)

Query: 40  ERYLRSY-YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGV 98
           E +L+ Y Y P     +    +A +M   L  MQ F+G+ +TGK+D NT+D MKKPRCGV
Sbjct: 44  EVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGV 103

Query: 99  PDV----GEYNVFPRTL-----KWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVT 149
           PD      ++++  +       KW   ++TY I N TP +   E  KA ++AF VW +VT
Sbjct: 104 PDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVT 163

Query: 150 PLNF-----TRLHDGI--ADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFD 202
           PL F     + L +G    DI I F    HGD  PFDG  G LAHA+ PGP  GGD HFD
Sbjct: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFD 223

Query: 203 DDETWTSSSK---GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDV 259
            DE WT  +    G +LFLVA HE GH+LGL+HS DP A+M P Y Y    +F LP+DD+
Sbjct: 224 SDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDL 283

Query: 260 QGIQSLYGPGDEDPNPKHP-----------------------------------KTPDKC 284
           QGIQ +YGP D+ P P  P                                     P+ C
Sbjct: 284 QGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNIC 343

Query: 285 DPSLSLDAITSLRGETMIFKDRFFWRLHPQQV-DAELFLTKSFWPELPNRIDAAYEHPSH 343
           D + +  AI  LR E  +FKD++FWR+   +V D        FW  LP  IDA YE+   
Sbjct: 344 DGNFNTLAI--LRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDG 401

Query: 344 DLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVW 403
           + +F F+G K+W      +  GYP  +  LG       I +A+ +ED GKT  F G++ W
Sbjct: 402 NFVF-FKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYW 460

Query: 404 RYDDTNHIMDKDYPRLIEEDFPGIGDKVDA--VYEKNGYIYFFNGPIQFEYSIWSNRIVR 461
           RY +    MD  YP+ I   + GI +      V+++NG+ YF+ G    EY  ++N+I++
Sbjct: 461 RYSEEMKTMDPGYPKPITV-WKGIPESPQGAFVHKENGFTYFYKGK---EYWKFNNQILK 516

Query: 462 VMP 464
           V P
Sbjct: 517 VEP 519


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score =  294 bits (753), Expect = 1e-79
 Identities = 176/462 (38%), Positives = 237/462 (51%), Gaps = 53/462 (11%)

Query: 40  ERYLRSY-YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGV 98
           E +L+ Y Y P        + +  S++  +  MQ F+GL+VTGK D +T+  M++PRCGV
Sbjct: 36  EAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGV 95

Query: 99  PD---------VGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVT 149
           PD         V       + LKW    +T+ I NYTP +      +A +KAF+VW   T
Sbjct: 96  PDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESAT 155

Query: 150 PLNFTRL--------HDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHF 201
           PL F  +        H+  ADIMI F    HGD  PFDG  G LAHA+ PGPN GGD HF
Sbjct: 156 PLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHF 215

Query: 202 DDDETWTSSSK---GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDD 258
           D  E WT  ++   G ++FLVA HE GH+LGL+HS DP A+M P Y +    +F+LPDDD
Sbjct: 216 DSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDD 275

Query: 259 VQGIQSLYG-----PGDEDPNPK---HPKTPDK----------CDPSLSLDAITSLRGET 300
            +GIQ LYG     P    P P+    P  PDK          CD   + D +  LRGE 
Sbjct: 276 RRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDG--NFDTVAMLRGEM 333

Query: 301 MIFKDRFFWRLHPQQV-DAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNG 359
            +FK+R+FWR+   QV D        FW  LP  I+ AYE      +F F+G K W  + 
Sbjct: 334 FVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVF-FKGDKHWVFDE 392

Query: 360 YDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRL 419
             +  GYPK I ELG      KI AA+ +   GKT  F GN+ +R+++    +D +YP+ 
Sbjct: 393 ASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKN 452

Query: 420 IE----------EDFPGIGDKVDAVYEKNGYIYFFNGPIQFE 451
           I+            F G  +     Y+ N Y  F N  ++ E
Sbjct: 453 IKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVE 494


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score =  293 bits (749), Expect = 3e-79
 Identities = 179/462 (38%), Positives = 235/462 (50%), Gaps = 63/462 (13%)

Query: 59  NAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTL------- 111
           ++A ++   +  MQ F+G+ VTG LD  T++ MKKPRCGVPD    +   R         
Sbjct: 102 HSAKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQ 161

Query: 112 KWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRL--HD-----GIADIM 164
           KW + ++TY I NYTP +   +  KA ++AF VW  VTPL F  +  H+       ADIM
Sbjct: 162 KWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIM 221

Query: 165 ISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWT---SSSKGYNLFLVAA 221
           I F    HGD  PFDG  G LAHA+ PGP  GGD HFD DE WT   ++  G +LFLVA 
Sbjct: 222 IFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAV 281

Query: 222 HEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNP------ 275
           HE GH+LGL+HS DP A+M P Y Y    +F LP DD+QGIQ +YGP  E   P      
Sbjct: 282 HELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPT 341

Query: 276 ------------KHPKTPDKCDPSL----------------SLDAITSLRGETMIFKDRF 307
                       KH + P    P L                + + +   RGE  +FKDR+
Sbjct: 342 LPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGTKPNICDGNFNTVALFRGEMFVFKDRW 401

Query: 308 FWRLHPQQV-DAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGY 366
           FWRL   +V +      + FW  LP RIDAAYE      +F F+G K+W      +  GY
Sbjct: 402 FWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVF-FKGDKYWVFKEVTVEPGY 460

Query: 367 PKKISELG--LPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDF 424
           P  + ELG  LP+E   I  A+ +E  GKT  F G + WRY +     D  YP+ I   +
Sbjct: 461 PHSLGELGSCLPRE--GIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITV-W 517

Query: 425 PGIGDKVDAVY-EKNG-YIYFFNGPIQFEYSIWSNRIVRVMP 464
            GI       +  K G Y YF+ G    +Y  + N+ + V P
Sbjct: 518 KGIPQAPQGAFISKEGYYTYFYKGR---DYWKFDNQKLSVEP 556


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score =  274 bits (701), Expect = 1e-73
 Identities = 174/499 (34%), Positives = 240/499 (48%), Gaps = 78/499 (15%)

Query: 39  AERYLRSY-YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCG 97
           AE +LR Y Y P     +    +A  +   L EMQ F+G+ VTG LD+ T + MK+PRCG
Sbjct: 53  AENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCG 112

Query: 98  VPDVGEYNVFPRTL-----------KWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWS 146
           VPD     V                KW+  +LT+ I NYT  +      +A ++AF+VW 
Sbjct: 113 VPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWE 172

Query: 147 DVTPLNFTRL-HDGI-------ADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGD 198
             TPL F  + ++ I       ADIM+ F    HGD  PFDG  G LAHA+ PGP  GGD
Sbjct: 173 QATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGD 232

Query: 199 AHFDDDETWTSSSK---GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLP 255
            HFD DE WT SS    G NLFLVA HE GH+LGL+HS +P A+M P Y +    +F LP
Sbjct: 233 THFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLP 292

Query: 256 DDDVQGIQSLYGPGDEDPNPKHP------------------------------------- 278
           +DD++GIQ LYG  D  P P  P                                     
Sbjct: 293 EDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGP 352

Query: 279 -------KTPDKCDPSL---SLDAITSLRGETMIFKDRFFWRL-HPQQVDAELFLTKSFW 327
                  + PD+  P++     D +  LRGE  +FK R+FWR+ H + +D        FW
Sbjct: 353 PVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFW 412

Query: 328 PELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVH 387
             LP  I AAYE      +F F+G ++W     ++  GYP+ ++  GL     +I  A+ 
Sbjct: 413 RGLPGDISAAYERQDGRFVF-FKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIW 471

Query: 388 FEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKN--GYIYFFN 445
           +E TG T  F  ++ WR+++     D  YP+ I   + GI       +  N   Y YF+ 
Sbjct: 472 WEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISV-WQGIPASPKGAFLSNDAAYTYFYK 530

Query: 446 GPIQFEYSIWSNRIVRVMP 464
           G    +Y  + N  +R+ P
Sbjct: 531 GT---KYWKFDNERLRMEP 546


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score =  245 bits (625), Expect = 7e-65
 Identities = 158/455 (34%), Positives = 213/455 (46%), Gaps = 48/455 (10%)

Query: 34  EDLQFAERYLRSY-YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMK 92
           EDL     +L  + Y P       +      +++ +  MQ F GLE TG LD+ TL +MK
Sbjct: 47  EDLSLGVEWLSRFGYLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMK 106

Query: 93  KPRCGVPDVG------EYNVFPRTLKWSKMNLTYRIVNYTPD--MTHSEVEKAFKKAFKV 144
            PRC +PD+            P   KW+K NL++R+  +  D  + H  V      A KV
Sbjct: 107 TPRCSLPDLPVLTQARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKV 166

Query: 145 WSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNY-GGDAHFDD 203
           WSD+ PLNF  +    ADI I F   +H D YPFDGP G +AHAF PG ++  GD HFDD
Sbjct: 167 WSDIAPLNFHEVAGSAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDD 226

Query: 204 DETWT---SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY--TYTGKSHFMLPDDD 258
           DE WT   S + G +LF VA HEFGH++GL H     ++M P Y         + LP +D
Sbjct: 227 DEAWTFRSSDAHGMDLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYED 286

Query: 259 VQGIQSLYG--------------------PGDEDPNPKHPKTPDKCDPSLSLDAITSLRG 298
              +  LYG                    P +    P     P +C  S   DA+  +RG
Sbjct: 287 KVRVWQLYGVRESVSPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRC--STHFDAVAQIRG 344

Query: 299 ETMIFKDRFFWRLHPQQ--VDAELFLTKSFWPELP---NRIDAAYEHPSHDLIFIFRGRK 353
           E   FK ++FWRL   +  V  +      FW  LP   + +DA YE  S   I  F+G +
Sbjct: 345 EAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDR 404

Query: 354 FWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMD 413
           +W     ++ EGYP+ +S+  LP     I AA  +    +T  F     WRYDD    MD
Sbjct: 405 YWVFKDNNVEEGYPRPVSDFSLPP--GGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMD 462

Query: 414 KDYPRL--IEEDFPGIGDKVDAVYEKNGYIYFFNG 446
             YP    +    P   D  DA+   +G  YFF G
Sbjct: 463 PGYPAQSPLWRGVPSTLD--DAMRWSDGASYFFRG 495


>gi|4505219 matrix metalloproteinase 7 preproprotein [Homo sapiens]
          Length = 267

 Score =  243 bits (619), Expect = 4e-64
 Identities = 120/250 (48%), Positives = 158/250 (63%), Gaps = 8/250 (3%)

Query: 19  ALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLE 78
           ALPLP   +   +SE   + A+ YL+ +Y   +     +   A+S+  +L+EMQ FFGL 
Sbjct: 17  ALPLPQ--EAGGMSELQWEQAQDYLKRFYLYDS-----ETKNANSLEAKLKEMQKFFGLP 69

Query: 79  VTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAF 138
           +TG L+   +++M+KPRCGVPDV EY++FP + KW+   +TYRIV+YT D+ H  V++  
Sbjct: 70  ITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLV 129

Query: 139 KKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGD 198
            KA  +W    PL+F ++  G ADIMI F    HGD YPFDGP   LAHAF PG   GGD
Sbjct: 130 SKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGD 189

Query: 199 AHFDDDETWT-SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDD 257
           AHFD+DE WT  SS G N    A HE GHSLG+ HS DP A+M+P Y      +F L  D
Sbjct: 190 AHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQD 249

Query: 258 DVQGIQSLYG 267
           D++GIQ LYG
Sbjct: 250 DIKGIQKLYG 259


>gi|149999365 matrix metalloproteinase 16 isoform 2 preproprotein
           [Homo sapiens]
          Length = 457

 Score =  239 bits (611), Expect = 3e-63
 Identities = 144/364 (39%), Positives = 189/364 (51%), Gaps = 58/364 (15%)

Query: 40  ERYLRSY-YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGV 98
           E +L+ Y Y P     +    +A +M   L  MQ F+G+ +TGK+D NT+D MKKPRCGV
Sbjct: 44  EVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGV 103

Query: 99  PDV----GEYNVFPRTL-----KWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVT 149
           PD      ++++  +       KW   ++TY I N TP +   E  KA ++AF VW +VT
Sbjct: 104 PDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVT 163

Query: 150 PLNF-----TRLHDGI--ADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFD 202
           PL F     + L +G    DI I F    HGD  PFDG  G LAHA+ PGP  GGD HFD
Sbjct: 164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFD 223

Query: 203 DDETWTSSSK---GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDV 259
            DE WT  +    G +LFLVA HE GH+LGL+HS DP A+M P Y Y    +F LP+DD+
Sbjct: 224 SDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDL 283

Query: 260 QGIQSLYGPGDEDPNPKHP-----------------------------------KTPDKC 284
           QGIQ +YGP D+ P P  P                                     P+ C
Sbjct: 284 QGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNIC 343

Query: 285 DPSLSLDAITSLRGETMIFKDRFFWRLHPQQV-DAELFLTKSFWPELPNRIDAAYEHPSH 343
           D + +  AI  LR E  +FKD++FWR+   +V D        FW  LP  IDA YE+   
Sbjct: 344 DGNFNTLAI--LRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDG 401

Query: 344 DLIF 347
           + +F
Sbjct: 402 NFVF 405


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score =  232 bits (591), Expect = 6e-61
 Identities = 147/392 (37%), Positives = 205/392 (52%), Gaps = 38/392 (9%)

Query: 91  MKKPRCGVPDVGE----YNVFPRTL----KWSKMNLTYRIVNYTPDMTHSEVEKAFKKAF 142
           ++ PRCGVPD  +     N   R +    +W K +LTYRI+ +   +   +V +   +A 
Sbjct: 75  LRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEAL 134

Query: 143 KVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFD 202
           KVWSDVTPL FT +H+G ADIMI F    HGD  PFDGP G+LAHAF P  +  GD HFD
Sbjct: 135 KVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFD 194

Query: 203 DDETWT-SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQG 261
            DETWT    +G +L  VAAHEFGH LGL H+    ALM   YT+  +    L  DD +G
Sbjct: 195 YDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTF--RYPLSLSPDDCRG 252

Query: 262 IQSLYG---------------PGDEDPN---PKHPKT-PDKCDPSLSLDAITSLRGETMI 302
           +Q LYG                   D N   P  P   PD C+   S DA++++RGE   
Sbjct: 253 VQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACE--ASFDAVSTIRGELFF 310

Query: 303 FKDRFFWRLHPQQVDAEL-FLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYD 361
           FK  F WRL   Q+      L    W  LP+ +DAA+E  +   I+ F+G ++W  +G  
Sbjct: 311 FKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFE-DAQGHIWFFQGAQYWVYDGEK 369

Query: 362 ILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIE 421
            + G P  ++ELGL +     +A V   +  K   F G   WR+  +   +D   PR   
Sbjct: 370 PVLG-PAPLTELGLVR-FPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRR-A 426

Query: 422 EDFPGIGDKVDAVY-EKNGYIYFFNGPIQFEY 452
            D+ G+  ++DA + + +GY YF  G + +++
Sbjct: 427 TDWRGVPSEIDAAFQDADGYAYFLRGRLYWKF 458


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score =  225 bits (574), Expect = 6e-59
 Identities = 159/462 (34%), Positives = 215/462 (46%), Gaps = 53/462 (11%)

Query: 32  SEEDLQFAERYLRSY-YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDV 90
           S +D+     +L  Y Y P       +  +   + + ++ MQ F GL  TG++D  T+  
Sbjct: 25  SAQDVSLGVDWLTRYGYLPPPHPAQAQLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVAT 84

Query: 91  MKKPRCGVPDV-GEYNVFPRTLK-------WSKMNLTYRIVNY--TPDMTHSEVEKAFKK 140
           M+KPRC +PDV G   +  R  +       W K  LT+R+ ++  +  ++   V      
Sbjct: 85  MRKPRCSLPDVLGVAGLVRRRRRYALSGSVWKKRTLTWRVRSFPQSSQLSQETVRVLMSY 144

Query: 141 AFKVWSDVTPLNFTRLHDGIA---DIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPN-YG 196
           A   W   + L F  +        DI+I F    H D YPFDG  G LAHAF PG +   
Sbjct: 145 ALMAWGMESGLTFHEVDSPQGQEPDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPIS 204

Query: 197 GDAHFDDDETWTSSSK---GYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY--TYTGKSH 251
           GD HFDD+ETWT  SK   G +LF VA HEFGH+LGL HS  P ++M P Y         
Sbjct: 205 GDTHFDDEETWTFGSKDGEGTDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPDK 264

Query: 252 FMLPDDDVQGIQSLYGPGDEDP-----------------NPKHPKT---PDKCDPSLSLD 291
           + L  DD  G+Q LYG   + P                 +P H  +   PD+C+   + D
Sbjct: 265 YRLSQDDRDGLQQLYGKAPQTPYDKPTRKPLAPPPQPPASPTHSPSFPIPDRCEG--NFD 322

Query: 292 AITSLRGETMIFKDRFFWRLHP--QQVDAELFLTKSFWPELPNR---IDAAYEHPSHDLI 346
           AI ++RGET  FK  +FWRL P  Q V         FW  LP +   + AAY       I
Sbjct: 323 AIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRI 382

Query: 347 FIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYD 406
            +F G +FW       LEG  + ++ELGLP   +++ A   +   GKT L  G Q WRYD
Sbjct: 383 LLFSGPQFWVFQDRQ-LEGGARPLTELGLPPG-EEVDAVFSWPQNGKTYLVRGRQYWRYD 440

Query: 407 DTNHIMDKDYPRLIE--EDFPGIGDKVDAVYEKNGYIYFFNG 446
           +     D  YPR +   E  P   D  D      G  YFF G
Sbjct: 441 EAAARPDPGYPRDLSLWEGAPPSPD--DVTVSNAGDTYFFKG 480


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score =  223 bits (568), Expect = 3e-58
 Identities = 112/258 (43%), Positives = 157/258 (60%), Gaps = 12/258 (4%)

Query: 199 AHFDDDETWT-SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDD 257
           A++DDD  W     +GY+LFLVAAHEFGH++GL+HS+DPGALM PIYTYT   +F L  D
Sbjct: 329 ANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYT--KNFRLSQD 386

Query: 258 DVQGIQSLYGPGDE-----DPNPK-HPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWR- 310
           D++GIQ LYG   +      P P   P TP+ C   +  D I  +RGE   FKDRF WR 
Sbjct: 387 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 446

Query: 311 LHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKI 370
           + P+       L  +FWPELP +IDA YE P  +    F G ++W  +   +  GYPK +
Sbjct: 447 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 506

Query: 371 SELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDK 430
           + LGLP +V+++ AA ++    KT +F+G++ WRY++    MD  +P+LI + +  I D 
Sbjct: 507 TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDN 566

Query: 431 VDAV--YEKNGYIYFFNG 446
           +DAV   +  G+ YFF G
Sbjct: 567 LDAVVDLQGGGHSYFFKG 584



 Score =  206 bits (525), Expect = 3e-53
 Identities = 98/169 (57%), Positives = 119/169 (70%), Gaps = 7/169 (4%)

Query: 41  RYLRSYYHPTNLAGILKENA-ASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVP 99
           +YL ++Y      G  KE+     + + L++MQ FFGL  TG LD NT++ M+KPRCG P
Sbjct: 2   QYLNTFY------GCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNP 55

Query: 100 DVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDG 159
           DV  YN FPR  KW K  +TYRI+ YTPD+    V+ AF +AF+VWSDVTPL F+R+HDG
Sbjct: 56  DVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDG 115

Query: 160 IADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWT 208
            ADIMI+FG  EHGD YPFDG  GLLAHAF PG   GGD+HFDDDE WT
Sbjct: 116 EADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWT 164


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score =  223 bits (568), Expect = 3e-58
 Identities = 112/258 (43%), Positives = 157/258 (60%), Gaps = 12/258 (4%)

Query: 199 AHFDDDETWT-SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDD 257
           A++DDD  W     +GY+LFLVAAHEFGH++GL+HS+DPGALM PIYTYT   +F L  D
Sbjct: 379 ANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYT--KNFRLSQD 436

Query: 258 DVQGIQSLYGPGDE-----DPNPK-HPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWR- 310
           D++GIQ LYG   +      P P   P TP+ C   +  D I  +RGE   FKDRF WR 
Sbjct: 437 DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT 496

Query: 311 LHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKI 370
           + P+       L  +FWPELP +IDA YE P  +    F G ++W  +   +  GYPK +
Sbjct: 497 VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL 556

Query: 371 SELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDK 430
           + LGLP +V+++ AA ++    KT +F+G++ WRY++    MD  +P+LI + +  I D 
Sbjct: 557 TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDN 616

Query: 431 VDAV--YEKNGYIYFFNG 446
           +DAV   +  G+ YFF G
Sbjct: 617 LDAVVDLQGGGHSYFFKG 634



 Score =  212 bits (539), Expect = 7e-55
 Identities = 105/196 (53%), Positives = 131/196 (66%), Gaps = 8/196 (4%)

Query: 15  THCRALPLPSGGDEDDLSEE-DLQFAERYLRSYYHPTNLAGILKENA-ASSMTERLREMQ 72
           +H  A P P      D++ + D + A +YL ++Y      G  KE+     + + L++MQ
Sbjct: 25  SHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFY------GCPKESCNLFVLKDTLKKMQ 78

Query: 73  SFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHS 132
            FFGL  TG LD NT++ M+KPRCG PDV  YN FPR  KW K  +TYRI+ YTPD+   
Sbjct: 79  KFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPE 138

Query: 133 EVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPG 192
            V+ AF +AF+VWSDVTPL F+R+HDG ADIMI+FG  EHGD YPFDG  GLLAHAF PG
Sbjct: 139 TVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPG 198

Query: 193 PNYGGDAHFDDDETWT 208
              GGD+HFDDDE WT
Sbjct: 199 TGVGGDSHFDDDELWT 214


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score =  216 bits (550), Expect = 4e-56
 Identities = 145/407 (35%), Positives = 205/407 (50%), Gaps = 34/407 (8%)

Query: 64  MTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTL--KWSKMNLTYR 121
           +TE LR  Q    L V+G+LDD T   M++PRCG+ D          L  +W K +LT+R
Sbjct: 53  ITEALRAFQEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFR 112

Query: 122 IVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISF-GIKEHGDFYPFDG 180
           I+N    +       A ++AF+ WS+V PL F  +  G ADI +SF G +       FDG
Sbjct: 113 ILNLPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDG 172

Query: 181 PSGLLAHAFPPGPNYGGDAHFDDDETWTSSS-KGYNLFLVAAHEFGHSLGLDHSKDPGAL 239
           P  +LAHA  P     G  HFD+DE WT  + +G NL ++AAHE GH+LGL HS+   AL
Sbjct: 173 PGRVLAHADIPEL---GSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQAL 229

Query: 240 MFPIYTYTGKSHFMLPDDDVQGIQSLYGP-----GDED----------PNPKHPK-TPDK 283
           M P+Y    + HF L  DDV GIQ+LYG       DE+          P P  P   PD 
Sbjct: 230 MAPVYE-GYRPHFKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDP 288

Query: 284 CDPSLSLDA-ITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPS 342
           C  S  LDA +   RG+T  FK  + W +        LF   + W  LP  +DAA   P 
Sbjct: 289 C--SSELDAMMLGPRGKTYAFKGDYVWTV-SDSGPGPLFRVSALWEGLPGNLDAAVYSPR 345

Query: 343 HDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQV 402
              I  F+G K W    + +  G+PKK++ +        + AA+++    K  LF G+  
Sbjct: 346 TQWIHFFKGDKVWRYINFKMSPGFPKKLNRV-----EPNLDAALYWPLNQKVFLFKGSGY 400

Query: 403 WRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYE-KNGYIYFFNGPI 448
           W++D+        YP+ I+  F G+ ++  A    ++G +YFF G +
Sbjct: 401 WQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKV 447



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 52/201 (25%), Positives = 76/201 (37%), Gaps = 24/201 (11%)

Query: 177 PFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYN-LFLVAAHEFGHSLGLDHSKD 235
           P   P      A   GP  G    F  D  WT S  G   LF V+A   G          
Sbjct: 284 PMPDPCSSELDAMMLGPR-GKTYAFKGDYVWTVSDSGPGPLFRVSALWEGL--------- 333

Query: 236 PGALMFPIYT-YTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAIT 294
           PG L   +Y+  T   HF   D   + I     PG        PK  ++ +P+L      
Sbjct: 334 PGNLDAAVYSPRTQWIHFFKGDKVWRYINFKMSPG-------FPKKLNRVEPNLDAALYW 386

Query: 295 SLRGETMIFKDRFFWR---LHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRG 351
            L  +  +FK   +W+   L      +     K  +  +PN+  AA        ++ F+G
Sbjct: 387 PLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQD-GRVYFFKG 445

Query: 352 RKFWALN-GYDILEGYPKKIS 371
           + +W LN    + +GYP+ IS
Sbjct: 446 KVYWRLNQQLRVEKGYPRNIS 466


>gi|73808266 matrix metalloproteinase 26 preproprotein [Homo
           sapiens]
          Length = 261

 Score =  196 bits (499), Expect = 3e-50
 Identities = 104/263 (39%), Positives = 144/263 (54%), Gaps = 14/263 (5%)

Query: 5   VLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSM 64
           +L   +FL W  C A+P+P   D      +   F E Y   ++     + +L +   + +
Sbjct: 5   ILRVTIFLPW--CFAVPVPPAADH-----KGWDFVEGYFHQFFLTKKESPLLTQETQTQL 57

Query: 65  TERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVN 124
            ++       F    T  LD     ++ +P CGVPD  + ++ P   KW+K  LTYRI+N
Sbjct: 58  LQQ-------FHRNGTDLLDMQMHALLHQPHCGVPDGSDTSISPGRCKWNKHTLTYRIIN 110

Query: 125 YTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGL 184
           Y  DM  S V+ +   A  +WS+VTPL F ++ +G ADI +SF    H D +PFDGP G+
Sbjct: 111 YPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGGI 170

Query: 185 LAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIY 244
           L HAF P     G  HFD +E W++S  GYNLFLVA HE GHSLGL HS +  ++M+P Y
Sbjct: 171 LGHAFLPNSGNPGVVHFDKNEHWSASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTY 230

Query: 245 TYTGKSHFMLPDDDVQGIQSLYG 267
            Y     F L  DD+Q IQ LYG
Sbjct: 231 WYHDPRTFQLSADDIQRIQHLYG 253


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score =  193 bits (490), Expect = 3e-49
 Identities = 159/489 (32%), Positives = 223/489 (45%), Gaps = 65/489 (13%)

Query: 5   VLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSM 64
           +L A   L W H  A P   GG E  L +E   F E+Y   Y +      + K   ++  
Sbjct: 8   LLRALQLLLWGHLDAQPAERGGQE--LRKEAEAFLEKY--GYLNEQ----VPKAPTSTRF 59

Query: 65  TERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTL------------- 111
           ++ +R  Q    L V+G LD  TL  M +PRCGV D   Y  +   +             
Sbjct: 60  SDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRR 119

Query: 112 ---------KWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLH-DGIA 161
                    KW K +L+YR+VN+   +    V  A + AF++WS+V+ L F      G A
Sbjct: 120 KKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPA 179

Query: 162 DIMISFGIKEHGDFY--PFDGPSGLLAHAFPPGPNYGGDAHFDDDETWT-SSSKGYNLFL 218
           DI ++F   +H D     FDGP G LAHAF P     G+AHFD DE W+ S  +G NLF+
Sbjct: 180 DIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRR---GEAHFDQDERWSLSRRRGRNLFV 236

Query: 219 VAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYG----------- 267
           V AHE GH+LGL HS  P ALM P Y   G+   +L  DDV  +QSLYG           
Sbjct: 237 VLAHEIGHTLGLTHSPAPRALMAPYYKRLGRD-ALLSWDDVLAVQSLYGKPLGGSVAVQL 295

Query: 268 PG----------DEDPNPKHPKTPDKCDPSLSLDAITSLRGETM-IFKDRFFWRLHPQQV 316
           PG             P  + P+T        S DAIT  R + + IFK   FW +     
Sbjct: 296 PGKLFTDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGN 355

Query: 317 DAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLP 376
            +E    +  W  LP  I+AA    +    + F+G + W   G   + G P+     GLP
Sbjct: 356 VSEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLP 415

Query: 377 KEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVD-AVY 435
           +      AA+ F    + +LF G + +        ++  YPR + +D+ GI ++V  A+ 
Sbjct: 416 RHP---DAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSL-QDWGGIPEEVSGALP 471

Query: 436 EKNGYIYFF 444
             +G I FF
Sbjct: 472 RPDGSIIFF 480


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score =  180 bits (457), Expect = 2e-45
 Identities = 101/217 (46%), Positives = 130/217 (59%), Gaps = 16/217 (7%)

Query: 35  DLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKP 94
           D Q AE YL  Y + T +A +  E+   S+   L  +Q    L  TG+LD  TL  M+ P
Sbjct: 41  DRQLAEEYLYRYGY-TRVAEMRGES--KSLGPALLLLQKQLSLPETGELDSATLKAMRTP 97

Query: 95  RCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFT 154
           RCGVPD+G +  F   LKW   N+TY I NY+ D+  + ++ AF +AF +WS VTPL FT
Sbjct: 98  RCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFT 157

Query: 155 RLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGY 214
           R++   ADI+I FG+ EHGD YPFDG  GLLAHAFPPGP   GDAHFDDDE W S  KG 
Sbjct: 158 RVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELW-SLGKG- 215

Query: 215 NLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSH 251
              +V    FG++       D  A  FP + + G+S+
Sbjct: 216 ---VVVPTRFGNA-------DGAACHFP-FIFEGRSY 241



 Score =  139 bits (350), Expect = 6e-33
 Identities = 94/302 (31%), Positives = 136/302 (45%), Gaps = 62/302 (20%)

Query: 199 AHFDDDETWT-SSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDD 257
           ++FD D+ W     +GY+LFLVAAHEFGH+LGLDHS  P ALM+P+Y +T      L  D
Sbjct: 377 SNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPP--LHKD 434

Query: 258 DVQGIQSLYGPGDED---------PNPKHPKT---------------------------- 280
           DV GI+ LYGP  E          P P  P T                            
Sbjct: 435 DVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPT 494

Query: 281 -PDKCDPSLS----------------LDAITSLRGETMIFKDRFFWRLHPQQVDAEL--F 321
            P    PS +                 DAI  +  +  +FKD  +WR    +       F
Sbjct: 495 GPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPF 554

Query: 322 LTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKK 381
           L    WP LP ++D+ +E      +F F GR+ W   G  +L   P+++ +LGL  +V +
Sbjct: 555 LIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLG--PRRLDKLGLGADVAQ 612

Query: 382 ISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYI 441
           ++ A+     GK LLFSG ++WR+D    ++D      ++  FPG+      V++     
Sbjct: 613 VTGALR-SGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYREKA 671

Query: 442 YF 443
           YF
Sbjct: 672 YF 673


>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score =  126 bits (317), Expect = 4e-29
 Identities = 138/498 (27%), Positives = 197/498 (39%), Gaps = 128/498 (25%)

Query: 35  DLQFAERYLRSY--------YHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDN 86
           DL  A+R+L  Y        + P+   G  +    +++ E +R  Q    L  +G+LD  
Sbjct: 49  DLHAAQRFLSRYGWSGVWAAWGPSP-EGPPETPKGAALAEAVRRFQRANALPASGELDAA 107

Query: 87  TLDVMKKPRCGVPDV-----------------GEYNVFPRT------------------- 110
           TL  M +PRCGVPD+                       PR                    
Sbjct: 108 TLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGA 167

Query: 111 -LKWSKMNLTYRIVN--YTPDMTHSEVEKAFKKAFKVWSDVTPLNFTR---LHDGIADIM 164
              +SK  L++R++    +  ++ ++  +    AF++WS+VTPL+F           DI 
Sbjct: 168 AQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIK 227

Query: 165 ISFGIKEH-GDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWT--SSSKGYNLFLVAA 221
           + FG   H G    FDG     AHA+  G     D HFDDDE +T  +S  G +L  VA 
Sbjct: 228 LGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTGISLLKVAV 282

Query: 222 HEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTP 281
           HE GH LGL H+   G++M P Y    +  F L   D + IQ LYG              
Sbjct: 283 HEIGHVLGLPHTYRTGSIMQPNYI-PQEPAFELDWSDRKAIQKLYG-------------- 327

Query: 282 DKCDPSL--SLDAITSLR---GETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDA 336
             C+ S   + D I   R   GE M+    +F+R               +W         
Sbjct: 328 -SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFR------------NSWYW--------- 365

Query: 337 AYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFED--TGKT 394
            YE+         R  +    +   IL G+P      G+P     I A VH       + 
Sbjct: 366 LYEN---------RNNRTRYGDPIQILTGWP------GIPTH--NIDAFVHIWTWKRDER 408

Query: 395 LLFSGNQVWRYDD------TNHIMDKDYPRLIEEDFPGIGDKVDAVY--EKNGYIYFFNG 446
             F GNQ WRYD       T     K YP+LI E FPGI   +D  +   +   IYFF  
Sbjct: 409 YFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKE 468

Query: 447 PIQFEYSIWSNRIVRVMP 464
            + F + +  NR++   P
Sbjct: 469 SLVFAFDVNRNRVLNSYP 486


>gi|5902004 matrix metalloproteinase 23B precursor [Homo sapiens]
          Length = 390

 Score =  101 bits (252), Expect = 1e-21
 Identities = 69/181 (38%), Positives = 95/181 (52%), Gaps = 22/181 (12%)

Query: 104 YNVFPRTLKWSKMNLTYRIVNYTPDM-THSEVEKAFKKAFKVWSDVTPLNFTRLH-DGIA 161
           Y + P  L+W   NLTYRI+++  ++ +  E  +A   AF++WSDV+P +F  +  +  +
Sbjct: 79  YTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAPEQPS 138

Query: 162 DIMISFGIKEHGD------FYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYN 215
           D+ I F    H D       + FDGP+G LAHAF P P+  G  HFDD E W      Y+
Sbjct: 139 DLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFP-PH--GGIHFDDSEYWVLGPTRYS 195

Query: 216 ---------LFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLY 266
                    L  VAAHE GH+LGL HS+   ALM    T  G     L  D++ G+  LY
Sbjct: 196 WKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWK--ALSQDELWGLHRLY 253

Query: 267 G 267
           G
Sbjct: 254 G 254


>gi|169203154 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 358

 Score = 90.5 bits (223), Expect = 3e-18
 Identities = 70/248 (28%), Positives = 112/248 (45%), Gaps = 65/248 (26%)

Query: 38  FAERYLRSYYH--PTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPR 95
           F  +YL + Y+   + +  I ++  +S + E+L++MQ+FFGL+                 
Sbjct: 143 FPVKYLENCYYNLKSEINQIGRQRDSSPVLEKLKQMQNFFGLKDQ--------------- 187

Query: 96  CGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTR 155
                                       NY P++   +V++A  KAF++WS+ + L FTR
Sbjct: 188 ----------------------------NYMPNLPQEDVDRATGKAFELWSNASALTFTR 219

Query: 156 LHDGIADIMISFG-IKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGY 214
             +   DI++SF  + +  D  PF G  G LAHAFPPGP  GGD HFD+DET T   +  
Sbjct: 220 DFESEGDIILSFVFLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFRSS 279

Query: 215 NLFLVAAHEFGHSLGLDHSKDPGALMFP---------IYTY-TGKSHFMLP------DDD 258
             ++V   +       D      + +FP         IY   TGK+HF +       D++
Sbjct: 280 KHWVVQEDQLLSGYPRDVY---SSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDEN 336

Query: 259 VQGIQSLY 266
           +Q + + Y
Sbjct: 337 MQSVDAGY 344



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 36/83 (43%), Positives = 50/83 (60%), Gaps = 2/83 (2%)

Query: 349 FRGRKFWALNGYDILEGYPKKI-SELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDD 407
           FR  K W +    +L GYP+ + S    P+ VKKI AA++ +DTGKT  F  N+ WRYD+
Sbjct: 276 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 335

Query: 408 TNHIMDKDYPRLIEEDFPGIGDK 430
               +D  YP++I +D PGI  K
Sbjct: 336 NMQSVDAGYPKII-DDLPGISKK 357


>gi|169203660 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score = 89.4 bits (220), Expect = 7e-18
 Identities = 60/184 (32%), Positives = 90/184 (48%), Gaps = 20/184 (10%)

Query: 100 DVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDG 159
           D+  YN       W  +       NY P++   +V++A  KAF++WS+ + L FTR  + 
Sbjct: 4   DLRVYNTVFSPDDWRGIQKWQEDQNYMPNLPQEDVDRATGKAFELWSNASALTFTRDFES 63

Query: 160 IADIMISFG-IKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFL 218
             DI++SF  + +  D  PF G  G LAHAFPPGP  GGD HFD+DET T   +    ++
Sbjct: 64  EGDIILSFVFLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFRSSKHWV 123

Query: 219 VAAHEFGHSLGLDHSKDPGALMFP---------IYTY-TGKSHFMLP------DDDVQGI 262
           V   +       D      + +FP         IY   TGK+HF +       D+++Q +
Sbjct: 124 VQEDQLLSGYPRDVY---SSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSV 180

Query: 263 QSLY 266
            + Y
Sbjct: 181 DAGY 184



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 36/83 (43%), Positives = 50/83 (60%), Gaps = 2/83 (2%)

Query: 349 FRGRKFWALNGYDILEGYPKKI-SELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDD 407
           FR  K W +    +L GYP+ + S    P+ VKKI AA++ +DTGKT  F  N+ WRYD+
Sbjct: 116 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 175

Query: 408 TNHIMDKDYPRLIEEDFPGIGDK 430
               +D  YP++I +D PGI  K
Sbjct: 176 NMQSVDAGYPKII-DDLPGISKK 197


>gi|169202084 PREDICTED: similar to hCG2042634 [Homo sapiens]
          Length = 198

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 60/184 (32%), Positives = 89/184 (48%), Gaps = 20/184 (10%)

Query: 100 DVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDG 159
           D+  YN       W  +       NY P++   +V++A  KAF++WS  + L FTR  + 
Sbjct: 4   DLRVYNTVFSPDDWRGIQKWQEDQNYMPNLPQEDVDRATGKAFELWSKASALTFTRDFES 63

Query: 160 IADIMISFG-IKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFL 218
             DI++SF  + +  D  PF G  G LAHAFPPGP  GGD HFD+DET T   +    ++
Sbjct: 64  EGDIILSFVFLADLHDNSPFYGHDGCLAHAFPPGPGIGGDVHFDNDETRTKDFRSSKHWV 123

Query: 219 VAAHEFGHSLGLDHSKDPGALMFP---------IYTY-TGKSHFMLP------DDDVQGI 262
           V   +       D      + +FP         IY   TGK+HF +       D+++Q +
Sbjct: 124 VQEDQLLSGYPRDVY---SSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDENMQSV 180

Query: 263 QSLY 266
            + Y
Sbjct: 181 DAGY 184



 Score = 75.1 bits (183), Expect = 1e-13
 Identities = 36/83 (43%), Positives = 50/83 (60%), Gaps = 2/83 (2%)

Query: 349 FRGRKFWALNGYDILEGYPKKI-SELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDD 407
           FR  K W +    +L GYP+ + S    P+ VKKI AA++ +DTGKT  F  N+ WRYD+
Sbjct: 116 FRSSKHWVVQEDQLLSGYPRDVYSSFVFPERVKKIDAAIYEKDTGKTHFFVANEYWRYDE 175

Query: 408 TNHIMDKDYPRLIEEDFPGIGDK 430
               +D  YP++I +D PGI  K
Sbjct: 176 NMQSVDAGYPKII-DDLPGISKK 197


>gi|239750339 PREDICTED: hypothetical protein XP_002347374 [Homo
           sapiens]
          Length = 183

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 46/121 (38%), Positives = 64/121 (52%), Gaps = 3/121 (2%)

Query: 64  MTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTL--KWSKMNLTYR 121
           +TE LR  Q    L V+G+LDD T   M++PRCG+ D          L  +W K +LT+R
Sbjct: 53  ITEALRAFQEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFR 112

Query: 122 IVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISF-GIKEHGDFYPFDG 180
           I+N    +       A ++AF+ WS+V PL F  +  G ADI +SF G +       FDG
Sbjct: 113 ILNLPSTLPPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDG 172

Query: 181 P 181
           P
Sbjct: 173 P 173


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.140    0.447 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,900,135
Number of Sequences: 37866
Number of extensions: 1028489
Number of successful extensions: 2365
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 2126
Number of HSP's gapped (non-prelim): 100
length of query: 471
length of database: 18,247,518
effective HSP length: 106
effective length of query: 365
effective length of database: 14,233,722
effective search space: 5195308530
effective search space used: 5195308530
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.