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Search of human proteins with 130977759
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|130977759 tec protein tyrosine kinase [Homo sapiens]
(631 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 1309 0.0
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 758 0.0
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 714 0.0
gi|148596974 TXK tyrosine kinase [Homo sapiens] 614 e-176
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 608 e-174
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 608 e-174
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 337 2e-92
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 337 2e-92
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 332 6e-91
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 332 6e-91
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 332 6e-91
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 332 6e-91
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 332 6e-91
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 325 6e-89
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 323 4e-88
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 322 5e-88
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 322 5e-88
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 321 1e-87
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 321 1e-87
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 321 1e-87
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 320 3e-87
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 320 3e-87
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 315 6e-86
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 314 1e-85
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 309 6e-84
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 309 6e-84
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 309 6e-84
gi|4503787 fyn-related kinase [Homo sapiens] 304 2e-82
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 278 1e-74
gi|187475373 c-src tyrosine kinase [Homo sapiens] 274 2e-73
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 1309 bits (3387), Expect = 0.0
Identities = 631/631 (100%), Positives = 631/631 (100%)
Query: 1 MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK 60
MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK
Sbjct: 1 MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK 60
Query: 61 CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY 120
CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY
Sbjct: 61 CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY 120
Query: 121 HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS 180
HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS
Sbjct: 121 HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS 180
Query: 181 EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN 240
EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN
Sbjct: 181 EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN 240
Query: 241 NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY 300
NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY
Sbjct: 241 NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY 300
Query: 301 HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY 360
HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY
Sbjct: 301 HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY 360
Query: 361 EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL 420
EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL
Sbjct: 361 EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL 420
Query: 421 THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL 480
THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL
Sbjct: 421 THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL 480
Query: 481 ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS 540
ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS
Sbjct: 481 ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS 540
Query: 541 RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR 600
RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR
Sbjct: 541 RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR 600
Query: 601 CWQEKPEGRPSFEDLLRTIDELVECEETFGR 631
CWQEKPEGRPSFEDLLRTIDELVECEETFGR
Sbjct: 601 CWQEKPEGRPSFEDLLRTIDELVECEETFGR 631
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 758 bits (1956), Expect = 0.0
Identities = 366/626 (58%), Positives = 469/626 (74%), Gaps = 11/626 (1%)
Query: 1 MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGR-AEKKYRKGFIDVSKI 59
MN +LEE LIK+SQQK++TSP N+K R FVLTK+ L Y+E R +K+ KG I++S+I
Sbjct: 1 MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI 60
Query: 60 KCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIK 119
KCVEIVK+D IPC KYPFQVVHD LY+FAP +SR WV LKEE +NNN+++ K
Sbjct: 61 KCVEIVKSDIS-IPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPK 119
Query: 120 YHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDN 179
YHP FW DG ++CC Q EKLA GC +Y+ +++ +K LPP PE +R PL E +
Sbjct: 120 YHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRR------PLWEPE- 172
Query: 180 SEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKS 239
E +V+A+YD+Q + +L L R +EY +L+ +++HWWR +D+ G+EGY+PS+Y+ K
Sbjct: 173 -ETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSP 231
Query: 240 NNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTK-FGGEGSSGFR 298
NNL+ YEWY ++++R KAE+LL KEG FMVRDS G YTVS++TK E + +
Sbjct: 232 NNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIK 291
Query: 299 HYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGF 358
HYHIKET +PK+YY+AEK+ F SIP +I YH+HN GLVTRLRYPV + AP TAG
Sbjct: 292 HYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGL 351
Query: 359 SYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMM 418
Y KW I+PSELTF++E+GSG FG+V LG W + KVAIK IREGAM EEDFIEEA+VMM
Sbjct: 352 RYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMM 411
Query: 419 KLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGME 478
KL+HPKLVQLYGVC +Q PI +V EFME GCL ++LR ++G F+ + LL MC DVCEGM
Sbjct: 412 KLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMA 471
Query: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
YLE IHRDLAARNCLV E V+KVSDFGM R+VLDDQYTSS+G KFPVKW PEVF+
Sbjct: 472 YLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFS 531
Query: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
+SR+SSKSDVWSFGVLMWEVF+EG++P+E +N EVV ++ G RLY+P+LAS +VY++M
Sbjct: 532 FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIM 591
Query: 599 LRCWQEKPEGRPSFEDLLRTIDELVE 624
CW+E+PE RP+F LLR + E+ E
Sbjct: 592 NHCWKERPEDRPAFSRLLRQLAEIAE 617
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 714 bits (1843), Expect = 0.0
Identities = 354/657 (53%), Positives = 468/657 (71%), Gaps = 39/657 (5%)
Query: 6 ILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYE---GRAEKKYRKGFIDVSKIKCV 62
ILE I +KRSQQKKKTSPLN+K+RLF+LT L+YYE R + +KG IDV KI CV
Sbjct: 5 ILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCV 64
Query: 63 EIV---KND--DGVIPCQNK---------------YPFQVVHDANTLYIFAPSPQSRDLW 102
E V KN + IP + + YPFQVV+D LY+F+P+ + R W
Sbjct: 65 ETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRW 124
Query: 103 VKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIR-------- 154
+ +LK I+ N++++ KYHP FW DG Y CC QT K A GC+ S++
Sbjct: 125 IHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKT 184
Query: 155 -KALPPAPETKK--RRPPPPIPLEEEDNSEEI--VVAMYDFQAAEGHDLRLERGQEYLIL 209
K LPP PE + ++P PP P ++ E+ VVA+YD+ +DL+L +G EY IL
Sbjct: 185 KKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFIL 244
Query: 210 EKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGG 269
E++++ WWRARDK G EGYIPSNYVT + ++++ YEWY ++M RS+AEQLL+ E KEGG
Sbjct: 245 EESNLPWWRARDKNGQEGYIPSNYVT-EAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGG 303
Query: 270 FMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEY 329
F+VRDSS+ G YTVS++ K G+ RHY + T S +YYLAEKH F +IPE+I Y
Sbjct: 304 FIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQS--QYYLAEKHLFSTIPELINY 361
Query: 330 HKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKW 389
H+HN+AGL++RL+YPVS + KNAP+TAG Y WEI+P +LTF++ELG+G FGVV+ GKW
Sbjct: 362 HQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW 421
Query: 390 RAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGC 449
R QY VAIK I+EG+M E++FIEEAKVMM L+H KLVQLYGVCT+Q+PI+I+TE+M GC
Sbjct: 422 RGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGC 481
Query: 450 LLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFG 509
LLN+LR+ + F LL MC+DVCE MEYLE F+HRDLAARNCLV++ GVVKVSDFG
Sbjct: 482 LLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFG 541
Query: 510 MARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKY 569
++RYVLDD+YTSS G+KFPV+W PPEV YS+FSSKSD+W+FGVLMWE+++ G+MP+E++
Sbjct: 542 LSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERF 601
Query: 570 TNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECE 626
TN E + +G RLY+P LAS VY +M CW EK + RP+F+ LL I ++++ E
Sbjct: 602 TNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEE 658
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 614 bits (1584), Expect = e-176
Identities = 290/463 (62%), Positives = 359/463 (77%), Gaps = 2/463 (0%)
Query: 162 ETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD 221
+ KR+P PP+P E + V A+YDF E +L L R +EYLILEK + HWW+ARD
Sbjct: 65 QPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD 124
Query: 222 KYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLY 281
+ GNEG IPSNYVT K NL+ YEWY RN+ R++AE LLR E KEG F+VRDS G Y
Sbjct: 125 RLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSY 184
Query: 282 TVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRL 341
T+S++ + +HY IK+ + ++Y+AE+HAF SIPE+I YH+HNAAGL+TRL
Sbjct: 185 TISVFMGARRSTEAAIKHYQIKKNDSG--QWYVAERHAFQSIPELIWYHQHNAAGLMTRL 242
Query: 342 RYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR 401
RYPV + G P TAGFSYEKWEI+PSEL F++E+GSG FGVV LG+WR+ +VAIKAI
Sbjct: 243 RYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAIN 302
Query: 402 EGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHF 461
EG+M EEDFIEEAKVMMKL+H KLVQLYGVC Q+KP+YIVTEFME GCLLN+LR+ +G
Sbjct: 303 EGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKL 362
Query: 462 SRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTS 521
+++LLS+CQD+CEGMEYLERN +IHRDLAARNCLVS +VK+SDFGM RYVLDD+Y S
Sbjct: 363 RKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVS 422
Query: 522 SSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRG 581
S GAKFP+KW PPEVF ++++SSKSDVWSFGVLMWEVFTEG+MPFE +N +VV ++ G
Sbjct: 423 SFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEG 482
Query: 582 HRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVE 624
RLY+P LA +YEVM CW EKPEGRP+F +LLR + E+ E
Sbjct: 483 FRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAE 525
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 608 bits (1567), Expect = e-174
Identities = 313/675 (46%), Positives = 430/675 (63%), Gaps = 55/675 (8%)
Query: 1 MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYE-GRAEKKYRKGFIDVSKI 59
M+ +ILEE+L+KRSQQKKK SP NYKERLFVLTK+ L+YYE + ++ RKG I++ KI
Sbjct: 1 MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI 60
Query: 60 KCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIK 119
+CVE V ++ P + +YPFQ+V+ LY++A + +SR W+K L++EI+ N ++++K
Sbjct: 61 RCVEKVNLEEQT-PVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVK 119
Query: 120 YHPKFWTDGSYQCCRQTEKLAPGC---------------EKYNL--FESSIRKALPPAPE 162
YH F+ DG + CC+Q+ K APGC EK+ + F + K P
Sbjct: 120 YHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPV 179
Query: 163 TKKRRPPPPIPLEEEDN-----------SEEIVVAMYDFQAAEGHDLRLERGQEYLILEK 211
K P L + DN S +A YD + + + + +Y+ E
Sbjct: 180 LKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPRE- 238
Query: 212 NDVHWWRARD----------KYGNEGYIPSNYVTGKKS------------NNLDQYEWYC 249
+ WW+ R N+ N+ T K S NLD Y+W+
Sbjct: 239 DFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFA 298
Query: 250 RNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSP 309
N++RS++EQLLR + KEG FMVR+SSQ G+YTVSL++K + +HYH+ T +
Sbjct: 299 GNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVH--TNAE 356
Query: 310 KKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSE 369
K YLAE + F SIP++I YH+HN+AG++TRLR+PVS K P + WE+ E
Sbjct: 357 NKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREE 416
Query: 370 LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLY 429
+T ++ELGSG FGVV+LGKW+ QY VA+K I+EG+M E++F +EA+ MMKL+HPKLV+ Y
Sbjct: 417 ITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFY 476
Query: 430 GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRD 489
GVC+++ PIYIVTE++ GCLLN+LR LL MC DVCEGM +LE + FIHRD
Sbjct: 477 GVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRD 536
Query: 490 LAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW 549
LAARNCLV VKVSDFGM RYVLDDQY SS G KFPVKW PEVF+Y ++SSKSDVW
Sbjct: 537 LAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVW 596
Query: 550 SFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGR 609
+FG+LMWEVF+ G+ P++ Y N +VV V++GHRLY+P LAS+ +Y++M CW E PE R
Sbjct: 597 AFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKR 656
Query: 610 PSFEDLLRTIDELVE 624
P+F+ LL +I+ L E
Sbjct: 657 PTFQQLLSSIEPLRE 671
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 608 bits (1567), Expect = e-174
Identities = 313/675 (46%), Positives = 430/675 (63%), Gaps = 55/675 (8%)
Query: 1 MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYE-GRAEKKYRKGFIDVSKI 59
M+ +ILEE+L+KRSQQKKK SP NYKERLFVLTK+ L+YYE + ++ RKG I++ KI
Sbjct: 1 MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI 60
Query: 60 KCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIK 119
+CVE V ++ P + +YPFQ+V+ LY++A + +SR W+K L++EI+ N ++++K
Sbjct: 61 RCVEKVNLEEQT-PVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVK 119
Query: 120 YHPKFWTDGSYQCCRQTEKLAPGC---------------EKYNL--FESSIRKALPPAPE 162
YH F+ DG + CC+Q+ K APGC EK+ + F + K P
Sbjct: 120 YHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPV 179
Query: 163 TKKRRPPPPIPLEEEDN-----------SEEIVVAMYDFQAAEGHDLRLERGQEYLILEK 211
K P L + DN S +A YD + + + + +Y+ E
Sbjct: 180 LKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPRE- 238
Query: 212 NDVHWWRARD----------KYGNEGYIPSNYVTGKKS------------NNLDQYEWYC 249
+ WW+ R N+ N+ T K S NLD Y+W+
Sbjct: 239 DFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFA 298
Query: 250 RNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSP 309
N++RS++EQLLR + KEG FMVR+SSQ G+YTVSL++K + +HYH+ T +
Sbjct: 299 GNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVH--TNAE 356
Query: 310 KKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSE 369
K YLAE + F SIP++I YH+HN+AG++TRLR+PVS K P + WE+ E
Sbjct: 357 NKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREE 416
Query: 370 LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLY 429
+T ++ELGSG FGVV+LGKW+ QY VA+K I+EG+M E++F +EA+ MMKL+HPKLV+ Y
Sbjct: 417 ITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFY 476
Query: 430 GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRD 489
GVC+++ PIYIVTE++ GCLLN+LR LL MC DVCEGM +LE + FIHRD
Sbjct: 477 GVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRD 536
Query: 490 LAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW 549
LAARNCLV VKVSDFGM RYVLDDQY SS G KFPVKW PEVF+Y ++SSKSDVW
Sbjct: 537 LAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVW 596
Query: 550 SFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGR 609
+FG+LMWEVF+ G+ P++ Y N +VV V++GHRLY+P LAS+ +Y++M CW E PE R
Sbjct: 597 AFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKR 656
Query: 610 PSFEDLLRTIDELVE 624
P+F+ LL +I+ L E
Sbjct: 657 PTFQQLLSSIEPLRE 671
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 337 bits (865), Expect = 2e-92
Identities = 183/453 (40%), Positives = 279/453 (61%), Gaps = 20/453 (4%)
Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
+N + VA+YDF A+ + L + +G++ +L N + W A+ K G +G++PSNY+T
Sbjct: 60 ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYIT- 117
Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
N+L+++ WY ++R+ AE LL S G F+VR+S S PG ++SL ++ G
Sbjct: 118 -PVNSLEKHSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISL--RYEG---- 169
Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
R YH + T S K Y++ + F ++ E++ +H A GL+T L YP + K PT
Sbjct: 170 --RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNK--PTV 225
Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
G S Y+KWE+ +++T +LG G +G V G W+ VA+K ++E M E+F++
Sbjct: 226 YGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 285
Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
EA VM ++ HP LVQL GVCT++ P YI+TEFM G LL++LR+ + + VLL M
Sbjct: 286 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 345
Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
+ MEYLE+ +FIHRDLAARNCLV E +VKV+DFG++R + D YT+ +GAKFP+KW
Sbjct: 346 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 405
Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
PE Y++FS KSDVW+FGVL+WE+ T G P+ +V ++ + +R+ +P+
Sbjct: 406 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 465
Query: 592 NYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVE 624
VYE+M CWQ P RPSF ++ + + + +
Sbjct: 466 EKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 498
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 337 bits (865), Expect = 2e-92
Identities = 183/453 (40%), Positives = 279/453 (61%), Gaps = 20/453 (4%)
Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
+N + VA+YDF A+ + L + +G++ +L N + W A+ K G +G++PSNY+T
Sbjct: 79 ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYIT- 136
Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
N+L+++ WY ++R+ AE LL S G F+VR+S S PG ++SL ++ G
Sbjct: 137 -PVNSLEKHSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISL--RYEG---- 188
Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
R YH + T S K Y++ + F ++ E++ +H A GL+T L YP + K PT
Sbjct: 189 --RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNK--PTV 244
Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
G S Y+KWE+ +++T +LG G +G V G W+ VA+K ++E M E+F++
Sbjct: 245 YGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 304
Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
EA VM ++ HP LVQL GVCT++ P YI+TEFM G LL++LR+ + + VLL M
Sbjct: 305 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 364
Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
+ MEYLE+ +FIHRDLAARNCLV E +VKV+DFG++R + D YT+ +GAKFP+KW
Sbjct: 365 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 424
Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
PE Y++FS KSDVW+FGVL+WE+ T G P+ +V ++ + +R+ +P+
Sbjct: 425 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 484
Query: 592 NYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVE 624
VYE+M CWQ P RPSF ++ + + + +
Sbjct: 485 EKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 517
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 332 bits (851), Expect = 6e-91
Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)
Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
++ + VA+YDF A+ + L + +G++ +L N + W R K G +G++PSNY+T
Sbjct: 91 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 148
Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
N+L+++ WY ++RS AE LL S G F+VR+S S PG ++SL ++ G
Sbjct: 149 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 200
Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
R YH + TT+ K Y+ + F ++ E++ +H A GLVT L YP K PT
Sbjct: 201 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 256
Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
G S ++KWE+ +++T +LG G +G V +G W+ VA+K ++E M E+F++
Sbjct: 257 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 316
Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
EA VM ++ HP LVQL GVCT + P YIVTE+M G LL++LR+ + + VLL M
Sbjct: 317 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 376
Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
+ MEYLE+ +FIHRDLAARNCLV E VVKV+DFG++R + D YT+ +GAKFP+KW
Sbjct: 377 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 436
Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
PE Y+ FS KSDVW+FGVL+WE+ T G P+ +V ++ +G+R+ QP+
Sbjct: 437 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 496
Query: 592 NYVYEVMLRCWQEKPEGRPSFED 614
VYE+M CW+ P RPSF +
Sbjct: 497 PKVYELMRACWKWSPADRPSFAE 519
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 332 bits (851), Expect = 6e-91
Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)
Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
++ + VA+YDF A+ + L + +G++ +L N + W R K G +G++PSNY+T
Sbjct: 106 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 163
Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
N+L+++ WY ++RS AE LL S G F+VR+S S PG ++SL ++ G
Sbjct: 164 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 215
Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
R YH + TT+ K Y+ + F ++ E++ +H A GLVT L YP K PT
Sbjct: 216 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 271
Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
G S ++KWE+ +++T +LG G +G V +G W+ VA+K ++E M E+F++
Sbjct: 272 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 331
Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
EA VM ++ HP LVQL GVCT + P YIVTE+M G LL++LR+ + + VLL M
Sbjct: 332 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 391
Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
+ MEYLE+ +FIHRDLAARNCLV E VVKV+DFG++R + D YT+ +GAKFP+KW
Sbjct: 392 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 451
Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
PE Y+ FS KSDVW+FGVL+WE+ T G P+ +V ++ +G+R+ QP+
Sbjct: 452 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 511
Query: 592 NYVYEVMLRCWQEKPEGRPSFED 614
VYE+M CW+ P RPSF +
Sbjct: 512 PKVYELMRACWKWSPADRPSFAE 534
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 332 bits (851), Expect = 6e-91
Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)
Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
++ + VA+YDF A+ + L + +G++ +L N + W R K G +G++PSNY+T
Sbjct: 85 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 142
Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
N+L+++ WY ++RS AE LL S G F+VR+S S PG ++SL ++ G
Sbjct: 143 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 194
Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
R YH + TT+ K Y+ + F ++ E++ +H A GLVT L YP K PT
Sbjct: 195 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 250
Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
G S ++KWE+ +++T +LG G +G V +G W+ VA+K ++E M E+F++
Sbjct: 251 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 310
Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
EA VM ++ HP LVQL GVCT + P YIVTE+M G LL++LR+ + + VLL M
Sbjct: 311 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 370
Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
+ MEYLE+ +FIHRDLAARNCLV E VVKV+DFG++R + D YT+ +GAKFP+KW
Sbjct: 371 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 430
Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
PE Y+ FS KSDVW+FGVL+WE+ T G P+ +V ++ +G+R+ QP+
Sbjct: 431 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 490
Query: 592 NYVYEVMLRCWQEKPEGRPSFED 614
VYE+M CW+ P RPSF +
Sbjct: 491 PKVYELMRACWKWSPADRPSFAE 513
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 332 bits (851), Expect = 6e-91
Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)
Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
++ + VA+YDF A+ + L + +G++ +L N + W R K G +G++PSNY+T
Sbjct: 91 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 148
Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
N+L+++ WY ++RS AE LL S G F+VR+S S PG ++SL ++ G
Sbjct: 149 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 200
Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
R YH + TT+ K Y+ + F ++ E++ +H A GLVT L YP K PT
Sbjct: 201 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 256
Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
G S ++KWE+ +++T +LG G +G V +G W+ VA+K ++E M E+F++
Sbjct: 257 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 316
Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
EA VM ++ HP LVQL GVCT + P YIVTE+M G LL++LR+ + + VLL M
Sbjct: 317 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 376
Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
+ MEYLE+ +FIHRDLAARNCLV E VVKV+DFG++R + D YT+ +GAKFP+KW
Sbjct: 377 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 436
Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
PE Y+ FS KSDVW+FGVL+WE+ T G P+ +V ++ +G+R+ QP+
Sbjct: 437 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 496
Query: 592 NYVYEVMLRCWQEKPEGRPSFED 614
VYE+M CW+ P RPSF +
Sbjct: 497 PKVYELMRACWKWSPADRPSFAE 519
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 332 bits (851), Expect = 6e-91
Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)
Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
++ + VA+YDF A+ + L + +G++ +L N + W R K G +G++PSNY+T
Sbjct: 70 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 127
Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
N+L+++ WY ++RS AE LL S G F+VR+S S PG ++SL ++ G
Sbjct: 128 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 179
Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
R YH + TT+ K Y+ + F ++ E++ +H A GLVT L YP K PT
Sbjct: 180 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 235
Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
G S ++KWE+ +++T +LG G +G V +G W+ VA+K ++E M E+F++
Sbjct: 236 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 295
Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
EA VM ++ HP LVQL GVCT + P YIVTE+M G LL++LR+ + + VLL M
Sbjct: 296 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 355
Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
+ MEYLE+ +FIHRDLAARNCLV E VVKV+DFG++R + D YT+ +GAKFP+KW
Sbjct: 356 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 415
Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
PE Y+ FS KSDVW+FGVL+WE+ T G P+ +V ++ +G+R+ QP+
Sbjct: 416 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 475
Query: 592 NYVYEVMLRCWQEKPEGRPSFED 614
VYE+M CW+ P RPSF +
Sbjct: 476 PKVYELMRACWKWSPADRPSFAE 498
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 325 bits (834), Expect = 6e-89
Identities = 183/510 (35%), Positives = 292/510 (57%), Gaps = 21/510 (4%)
Query: 123 KFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEE 182
KF G + +P C Y +S K P P + P + E + +
Sbjct: 28 KFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK---PGPNSHNSNTPG---IREAGSEDI 81
Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
IVVA+YD++A DL ++G + ++LE++ WW+AR EGYIPSNYV + ++
Sbjct: 82 IVVALYDYEAIHHEDLSFQKGDQMVVLEESG-EWWKARSLATRKEGYIPSNYVA--RVDS 138
Query: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
L+ EW+ + ++R AE QLL + G FM+RDS + G Y++S+ +G + +H
Sbjct: 139 LETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDT-VKH 197
Query: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
Y I+ T +Y++ + F ++ E+++++K GL +L P P +
Sbjct: 198 YKIR--TLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKP----WE 251
Query: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419
+ WEI L ++LG+G FG V + + KVA+K ++ G+M E F+ EA VM
Sbjct: 252 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 311
Query: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478
L H KLV+L+ V T++ PIYI+TEFM +G LL+FL+ +G L+ + EGM
Sbjct: 312 LQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370
Query: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
++E+ ++IHRDL A N LVS + V K++DFG+AR + D++YT+ GAKFP+KW PE N
Sbjct: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430
Query: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
+ F+ KSDVWSFG+L+ E+ T GR+P+ +N EV+ + RG+R+ +P+ +Y +M
Sbjct: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIM 490
Query: 599 LRCWQEKPEGRPSFEDLLRTIDELVECEET 628
+RCW+ +PE RP+FE + +D+ E+
Sbjct: 491 MRCWKNRPEERPTFEYIQSVLDDFYTATES 520
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 323 bits (827), Expect = 4e-88
Identities = 188/476 (39%), Positives = 277/476 (58%), Gaps = 20/476 (4%)
Query: 157 LPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHW 216
LPP PPPP E D + VVA+YD+ A DL++ +G++ +L K W
Sbjct: 38 LPPLVVFNHLTPPPPD--EHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL-KGTGDW 94
Query: 217 WRARDKY-GNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRD 274
W AR G EGY+PSN+V +S L+ W+ R+ R +AE QLL +K G F++R+
Sbjct: 95 WLARSLVTGREGYVPSNFVARVES--LEMERWFFRSQGRKEAERQLLAPINKAGSFLIRE 152
Query: 275 S-SQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHN 333
S + G +++S+ K +HY I+ YY++ + F S+ +++++
Sbjct: 153 SETNKGAFSLSV--KDVTTQGELIKHYKIR--CLDEGGYYISPRITFPSLQALVQHYSKK 208
Query: 334 AAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQY 393
GL RL P P ++ ++WEI L +R+LGSG FG V +G ++
Sbjct: 209 GDGLCQRLTLPCVRPAPQNP----WAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNM 264
Query: 394 KVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNF 453
KVAIK ++EG M E F+ EA VM L H +LV+LY V T++ PIYIVTE+M RGCLL+F
Sbjct: 265 KVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PIYIVTEYMARGCLLDF 323
Query: 454 LRQRQG-HFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMAR 512
L+ +G S L+ M + EGM Y+ER + IHRDL A N LVSEA K++DFG+AR
Sbjct: 324 LKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLAR 383
Query: 513 YVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNY 572
++D +YT+ GAKFP+KW PE ++ F+ K+DVWSFGVL+ EV T GR+P+ +N
Sbjct: 384 -IIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNP 442
Query: 573 EVVTMVTRGHRLYQPKLASNYVYE-VMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
EV+ + RG+R+ +P +Y V+ CW+ +PE RP+FE L +++ E
Sbjct: 443 EVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATE 498
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 322 bits (826), Expect = 5e-88
Identities = 174/441 (39%), Positives = 266/441 (60%), Gaps = 13/441 (2%)
Query: 185 VAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNNLD 243
VA+YD+++ DL ++G+ I+ + WW A G GYIPSNYV S+++
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA--PSDSIQ 147
Query: 244 QYEWYCRNMNRSKAEQLL-RSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRHYH 301
EWY + R ++E+LL +E+ G F+VR+S + G Y +S+ + F +HY
Sbjct: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV-SDFDNAKGLNVKHYK 206
Query: 302 IKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYE 361
I++ + +Y+ + F S+ +++ Y+ +A GL RL +V + P T G + +
Sbjct: 207 IRKLDSGG--FYITSRTQFNSLQQLVAYYSKHADGLCHRL---TTVCPTSKPQTQGLAKD 261
Query: 362 KWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLT 421
WEI L +LG G FG V +G W +VAIK ++ G M E F++EA+VM KL
Sbjct: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 321
Query: 422 HPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGMEYL 480
H KLVQLY V +++ PIYIVTE+M +G LL+FL+ G + R L+ M + GM Y+
Sbjct: 322 HEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380
Query: 481 ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS 540
ER +++HRDL A N LV E V KV+DFG+AR + D++YT+ GAKFP+KW PE Y
Sbjct: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440
Query: 541 RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR 600
RF+ KSDVWSFG+L+ E+ T+GR+P+ N EV+ V RG+R+ P ++++M +
Sbjct: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500
Query: 601 CWQEKPEGRPSFEDLLRTIDE 621
CW+++PE RP+FE L +++
Sbjct: 501 CWRKEPEERPTFEYLQAFLED 521
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 322 bits (826), Expect = 5e-88
Identities = 174/441 (39%), Positives = 266/441 (60%), Gaps = 13/441 (2%)
Query: 185 VAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNNLD 243
VA+YD+++ DL ++G+ I+ + WW A G GYIPSNYV S+++
Sbjct: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA--PSDSIQ 147
Query: 244 QYEWYCRNMNRSKAEQLL-RSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRHYH 301
EWY + R ++E+LL +E+ G F+VR+S + G Y +S+ + F +HY
Sbjct: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV-SDFDNAKGLNVKHYK 206
Query: 302 IKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYE 361
I++ + +Y+ + F S+ +++ Y+ +A GL RL +V + P T G + +
Sbjct: 207 IRKLDSGG--FYITSRTQFNSLQQLVAYYSKHADGLCHRL---TTVCPTSKPQTQGLAKD 261
Query: 362 KWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLT 421
WEI L +LG G FG V +G W +VAIK ++ G M E F++EA+VM KL
Sbjct: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 321
Query: 422 HPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGMEYL 480
H KLVQLY V +++ PIYIVTE+M +G LL+FL+ G + R L+ M + GM Y+
Sbjct: 322 HEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380
Query: 481 ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS 540
ER +++HRDL A N LV E V KV+DFG+AR + D++YT+ GAKFP+KW PE Y
Sbjct: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440
Query: 541 RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR 600
RF+ KSDVWSFG+L+ E+ T+GR+P+ N EV+ V RG+R+ P ++++M +
Sbjct: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500
Query: 601 CWQEKPEGRPSFEDLLRTIDE 621
CW+++PE RP+FE L +++
Sbjct: 501 CWRKEPEERPTFEYLQAFLED 521
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 321 bits (822), Expect = 1e-87
Identities = 169/463 (36%), Positives = 279/463 (60%), Gaps = 20/463 (4%)
Query: 169 PPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEG 227
PP PL++ +V+A++ ++ + DL E+G++ ILE++ WW+A+ G EG
Sbjct: 56 PPASPLQDN-----LVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEG 109
Query: 228 YIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSL 285
+IP N+V K+N+L+ W+ +N++R AE QLL + G F++R+S S G +++S+
Sbjct: 110 FIPFNFVA--KANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSV 167
Query: 286 YTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPV 345
F +HY I+ +Y++ + F + E++ ++ + + GL TRL P
Sbjct: 168 -RDFDQNQGEVVKHYKIRNLDNGG--FYISPRITFPGLHELVRHYTNASDGLCTRLSRPC 224
Query: 346 SVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAM 405
+ P + ++WE+ L + LG+G FG V +G + KVA+K++++G+M
Sbjct: 225 QTQKPQKP----WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM 280
Query: 406 CEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG-HFSRD 464
+ F+ EA +M +L H +LV+LY V TQ+ PIYI+TE+ME G L++FL+ G + +
Sbjct: 281 SPDAFLAEANLMKQLQHQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTIN 339
Query: 465 VLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSG 524
LL M + EGM ++E ++IHRDL A N LVS+ K++DFG+AR + D++YT+ G
Sbjct: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399
Query: 525 AKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRL 584
AKFP+KW PE NY F+ KSDVWSFG+L+ E+ T GR+P+ TN EV+ + RG+R+
Sbjct: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
Query: 585 YQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
+P +Y++M CW+E+PE RP+F+ L +++ E
Sbjct: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATE 502
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 321 bits (822), Expect = 1e-87
Identities = 169/463 (36%), Positives = 279/463 (60%), Gaps = 20/463 (4%)
Query: 169 PPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEG 227
PP PL++ +V+A++ ++ + DL E+G++ ILE++ WW+A+ G EG
Sbjct: 56 PPASPLQDN-----LVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEG 109
Query: 228 YIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSL 285
+IP N+V K+N+L+ W+ +N++R AE QLL + G F++R+S S G +++S+
Sbjct: 110 FIPFNFVA--KANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSV 167
Query: 286 YTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPV 345
F +HY I+ +Y++ + F + E++ ++ + + GL TRL P
Sbjct: 168 -RDFDQNQGEVVKHYKIRNLDNGG--FYISPRITFPGLHELVRHYTNASDGLCTRLSRPC 224
Query: 346 SVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAM 405
+ P + ++WE+ L + LG+G FG V +G + KVA+K++++G+M
Sbjct: 225 QTQKPQKP----WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM 280
Query: 406 CEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG-HFSRD 464
+ F+ EA +M +L H +LV+LY V TQ+ PIYI+TE+ME G L++FL+ G + +
Sbjct: 281 SPDAFLAEANLMKQLQHQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTIN 339
Query: 465 VLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSG 524
LL M + EGM ++E ++IHRDL A N LVS+ K++DFG+AR + D++YT+ G
Sbjct: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399
Query: 525 AKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRL 584
AKFP+KW PE NY F+ KSDVWSFG+L+ E+ T GR+P+ TN EV+ + RG+R+
Sbjct: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459
Query: 585 YQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
+P +Y++M CW+E+PE RP+F+ L +++ E
Sbjct: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATE 502
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 321 bits (822), Expect = 1e-87
Identities = 177/452 (39%), Positives = 265/452 (58%), Gaps = 16/452 (3%)
Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
+ VA+YD++A DL +G+++ IL ++ WW AR G GYIPSNYV S
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDS-- 143
Query: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
+ EWY + R AE QLL + G F++R+S + G Y++S+ +G +H
Sbjct: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH-VKH 202
Query: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
Y I++ YY+ + F ++ ++++++ AAGL RL P K P S
Sbjct: 203 YKIRKLDNGG--YYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCH---KGMPRLTDLS 257
Query: 360 YEK---WEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKV 416
+ WEI L ++ LG+G FG V +G W KVAIK ++ G M E F+EEA++
Sbjct: 258 VKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQI 317
Query: 417 MMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCE 475
M KL H KLVQLY V +++ PIYIVTE+M +G LL+FL+ +G + L+ M V
Sbjct: 318 MKKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAA 376
Query: 476 GMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPE 535
GM Y+ER ++IHRDL + N LV + K++DFG+AR + D++YT+ GAKFP+KW PE
Sbjct: 377 GMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPE 436
Query: 536 VFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVY 595
Y RF+ KSDVWSFG+L+ E+ T+GR+P+ N EV+ V RG+R+ P+ ++
Sbjct: 437 AALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLH 496
Query: 596 EVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
E+M+ CW++ PE RP+FE L +++ E
Sbjct: 497 ELMIHCWKKDPEERPTFEYLQSFLEDYFTATE 528
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 320 bits (819), Expect = 3e-87
Identities = 173/449 (38%), Positives = 263/449 (58%), Gaps = 13/449 (2%)
Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
+ VA+YD++A DL +G+++ IL ++ WW AR G GYIPSNYV S
Sbjct: 86 LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDS-- 143
Query: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
+ EWY + R AE QLL + G F++R+S + G Y++S+ +G +H
Sbjct: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH-VKH 202
Query: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
Y I++ YY+ + F ++ ++++++ A GL L + P T+G +
Sbjct: 203 YKIRKLDNGG--YYITTRAQFETLQQLVQHYSEKADGLCFNLTV---IASSCTPQTSGLA 257
Query: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419
+ WE+ L ++LG G F V LG W KVAIK ++ G M E F+EEA++M K
Sbjct: 258 KDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKK 317
Query: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478
L H KLVQLY V +++ PIYIVTE+M +G LL+FL+ +G + L+ M V GM
Sbjct: 318 LKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMA 376
Query: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
Y+ER ++IHRDL + N LV + K++DFG+AR + D++YT+ GAKFP+KW PE
Sbjct: 377 YIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 436
Query: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
Y RF+ KSDVWSFG+L+ E+ T+GR+P+ N EV+ V RG+R+ P+ ++E+M
Sbjct: 437 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELM 496
Query: 599 LRCWQEKPEGRPSFEDLLRTIDELVECEE 627
+ CW++ PE RP+FE L +++ E
Sbjct: 497 IHCWKKDPEERPTFEYLQSFLEDYFTATE 525
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 320 bits (819), Expect = 3e-87
Identities = 174/451 (38%), Positives = 269/451 (59%), Gaps = 17/451 (3%)
Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
I VA+YD++A DL ++G+ + I+ + WW AR G GYIPSNYV +++
Sbjct: 95 IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVA--PADS 152
Query: 242 LDQYEWYCRNMNRSKAEQLLRSEDKEGG-FMVRDS-SQPGLYTVSL--YTKFGGEGSSGF 297
+ EWY M R AE+LL + + G F+VR+S + G Y++S+ + + G+
Sbjct: 153 IQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDN---V 209
Query: 298 RHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAG 357
+HY I++ YY+ + F ++ ++++++ +A GL +L +V P T G
Sbjct: 210 KHYKIRKLDNGG--YYITTRAQFDTLQKLVKHYTEHADGLCHKL---TTVCPTVKPQTQG 264
Query: 358 FSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVM 417
+ + WEI L +LG G FG V +G W KVAIK ++ G M E F++EA++M
Sbjct: 265 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIM 324
Query: 418 MKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEG 476
KL H KLV LY V +++ PIYIVTEFM +G LL+FL++ G + + L+ M + +G
Sbjct: 325 KKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADG 383
Query: 477 MEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEV 536
M Y+ER ++IHRDL A N LV E V K++DFG+AR + D++YT+ GAKFP+KW PE
Sbjct: 384 MAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 443
Query: 537 FNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYE 596
Y RF+ KSDVWSFG+L E+ T+GR+P+ N EV+ V RG+R+ P+ ++E
Sbjct: 444 ALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 503
Query: 597 VMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
+M CW++ P+ RP+FE + +++ E
Sbjct: 504 LMNLCWKKDPDERPTFEYIQSFLEDYFTATE 534
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 315 bits (808), Expect = 6e-86
Identities = 172/487 (35%), Positives = 283/487 (58%), Gaps = 15/487 (3%)
Query: 145 KYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQ 204
K +L + + P PE++ P ++ + +IVVA+Y + DL ++G+
Sbjct: 9 KDSLSDDGVDLKTQPVPESQLL-PGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGE 67
Query: 205 EYLILEKNDVHWWRARDKYGN-EGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLR 262
+ +LE++ WW+A+ EG+IPSNYV K N L+ EW+ +++ R AE QLL
Sbjct: 68 KMKVLEEHG-EWWKAKSLLTKKEGFIPSNYVA--KLNTLETEEWFFKDITRKDAERQLLA 124
Query: 263 SEDKEGGFMVRDSSQ-PGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFG 321
+ G F++R+S G +++S+ F +HY I+ YY++ + F
Sbjct: 125 PGNSAGAFLIRESETLKGSFSLSV-RDFDPVHGDVIKHYKIRSLDNGG--YYISPRITFP 181
Query: 322 SIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLF 381
I ++I++++ A GL RL P + + WEI + ++ LG+G F
Sbjct: 182 CISDMIKHYQKQADGLCRRLEKACISPKPQKP----WDKDAWEIPRESIKLVKRLGAGQF 237
Query: 382 GVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIV 441
G V +G + KVA+K ++ G M + F+EEA +M L H KLV+LY V T+++PIYI+
Sbjct: 238 GEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYII 297
Query: 442 TEFMERGCLLNFLRQRQG-HFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEA 500
TE+M +G LL+FL+ +G L+ + EGM Y+ER ++IHRDL A N LVSE+
Sbjct: 298 TEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSES 357
Query: 501 GVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFT 560
+ K++DFG+AR + D++YT+ GAKFP+KW PE N+ F+ KSDVWSFG+L++E+ T
Sbjct: 358 LMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVT 417
Query: 561 EGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTID 620
G++P+ TN +V+T +++G+R+ + + + +Y++M CW+EK E RP+F+ L +D
Sbjct: 418 YGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLD 477
Query: 621 ELVECEE 627
+ E
Sbjct: 478 DFYTATE 484
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 314 bits (805), Expect = 1e-85
Identities = 171/476 (35%), Positives = 279/476 (58%), Gaps = 22/476 (4%)
Query: 164 KKRRPPPPIPL--------EEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVH 215
K++RP P L ++ + +IVVA+Y + DL ++G++ +LE++
Sbjct: 40 KQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHG-E 98
Query: 216 WWRARDKYGN-EGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVR 273
WW+A+ EG+IPSNYV K N L+ EW+ +++ R AE QLL + G F++R
Sbjct: 99 WWKAKSLLTKKEGFIPSNYVA--KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIR 156
Query: 274 DSSQ-PGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKH 332
+S G +++S+ F +HY I+ YY++ + F I ++I++++
Sbjct: 157 ESETLKGSFSLSV-RDFDPVHGDVIKHYKIRSLDNGG--YYISPRITFPCISDMIKHYQK 213
Query: 333 NAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQ 392
A GL RL P + + WEI + ++ LG+G FG V +G +
Sbjct: 214 QADGLCRRLEKACISPKPQKP----WDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNS 269
Query: 393 YKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLN 452
KVA+K ++ G M + F+EEA +M L H KLV+LY V T+++PIYI+TE+M +G LL+
Sbjct: 270 TKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLD 329
Query: 453 FLRQRQG-HFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMA 511
FL+ +G L+ + EGM Y+ER ++IHRDL A N LVSE+ + K++DFG+A
Sbjct: 330 FLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLA 389
Query: 512 RYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTN 571
R + D++YT+ GAKFP+KW PE N+ F+ KSDVWSFG+L++E+ T G++P+ TN
Sbjct: 390 RVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTN 449
Query: 572 YEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
+V+T +++G+R+ + + + +Y++M CW+EK E RP+F+ L +D+ E
Sbjct: 450 ADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATE 505
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 309 bits (791), Expect = 6e-84
Identities = 174/443 (39%), Positives = 255/443 (57%), Gaps = 13/443 (2%)
Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
+ +A+YD++A DL +G+++ IL + WW AR G G IPSNYV S
Sbjct: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDS-- 138
Query: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
+ EWY + R AE QLL + +G F++R+S + G Y++S+ G +H
Sbjct: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH-VKH 197
Query: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
Y I++ YY+ + F S+ E+++++ GL L P ++ P T G +
Sbjct: 198 YKIRKLDMGG--YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM---KPQTLGLA 252
Query: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419
+ WEI+ S +T R LG+G FG V LG W KVA+K ++ G M + F+EEA+VM
Sbjct: 253 KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKL 312
Query: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478
L H KLVQLY V +++ PIYIVTEFM G LL+FL+ +G R L+ M V EGM
Sbjct: 313 LRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371
Query: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
Y+ER ++IHRDL A N LV E K++DFG+AR + DD+Y G+KFP+KW PE
Sbjct: 372 YMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAAL 431
Query: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
+ RF+ KSDVWSFG+L+ E+ T+GR+P+ EV+ V +G+ + P +YE M
Sbjct: 432 FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAM 491
Query: 599 LRCWQEKPEGRPSFEDLLRTIDE 621
+ W+ PE RP+FE L +++
Sbjct: 492 EQTWRLDPEERPTFEYLQSFLED 514
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 309 bits (791), Expect = 6e-84
Identities = 174/443 (39%), Positives = 255/443 (57%), Gaps = 13/443 (2%)
Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
+ +A+YD++A DL +G+++ IL + WW AR G G IPSNYV S
Sbjct: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDS-- 138
Query: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
+ EWY + R AE QLL + +G F++R+S + G Y++S+ G +H
Sbjct: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH-VKH 197
Query: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
Y I++ YY+ + F S+ E+++++ GL L P ++ P T G +
Sbjct: 198 YKIRKLDMGG--YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM---KPQTLGLA 252
Query: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419
+ WEI+ S +T R LG+G FG V LG W KVA+K ++ G M + F+EEA+VM
Sbjct: 253 KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKL 312
Query: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478
L H KLVQLY V +++ PIYIVTEFM G LL+FL+ +G R L+ M V EGM
Sbjct: 313 LRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371
Query: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
Y+ER ++IHRDL A N LV E K++DFG+AR + DD+Y G+KFP+KW PE
Sbjct: 372 YMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAAL 431
Query: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
+ RF+ KSDVWSFG+L+ E+ T+GR+P+ EV+ V +G+ + P +YE M
Sbjct: 432 FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAM 491
Query: 599 LRCWQEKPEGRPSFEDLLRTIDE 621
+ W+ PE RP+FE L +++
Sbjct: 492 EQTWRLDPEERPTFEYLQSFLED 514
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 309 bits (791), Expect = 6e-84
Identities = 174/443 (39%), Positives = 255/443 (57%), Gaps = 13/443 (2%)
Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
+ +A+YD++A DL +G+++ IL + WW AR G G IPSNYV S
Sbjct: 81 LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDS-- 138
Query: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
+ EWY + R AE QLL + +G F++R+S + G Y++S+ G +H
Sbjct: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH-VKH 197
Query: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
Y I++ YY+ + F S+ E+++++ GL L P ++ P T G +
Sbjct: 198 YKIRKLDMGG--YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM---KPQTLGLA 252
Query: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419
+ WEI+ S +T R LG+G FG V LG W KVA+K ++ G M + F+EEA+VM
Sbjct: 253 KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKL 312
Query: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478
L H KLVQLY V +++ PIYIVTEFM G LL+FL+ +G R L+ M V EGM
Sbjct: 313 LRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371
Query: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
Y+ER ++IHRDL A N LV E K++DFG+AR + DD+Y G+KFP+KW PE
Sbjct: 372 YMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAAL 431
Query: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
+ RF+ KSDVWSFG+L+ E+ T+GR+P+ EV+ V +G+ + P +YE M
Sbjct: 432 FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAM 491
Query: 599 LRCWQEKPEGRPSFEDLLRTIDE 621
+ W+ PE RP+FE L +++
Sbjct: 492 EQTWRLDPEERPTFEYLQSFLED 514
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 304 bits (778), Expect = 2e-82
Identities = 173/462 (37%), Positives = 257/462 (55%), Gaps = 29/462 (6%)
Query: 185 VAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD----KYGN----EGYIPSNYVTG 236
VA++D+QA DL G + +L+ WW AR + G+ +GYIPSNYV
Sbjct: 48 VALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAE 107
Query: 237 KKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGS 294
+S L W+ + RS AE QLL SE+K G F++R+S SQ G +++S+
Sbjct: 108 DRS--LQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD------G 159
Query: 295 SGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPT 354
+ +HY IK ++L + F ++ E + ++ + GL +L P AP
Sbjct: 160 AVVKHYRIKRLDEGG--FFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPF 217
Query: 355 TAGF-SYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEE 413
+ + ++WEI+ + + ++ LGSG FG V G W VA+K ++ G+M DF+ E
Sbjct: 218 DLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLRE 277
Query: 414 AKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG---HFSRDVLLSMC 470
A++M L HPKL+QLY VCT + PIYI+TE M G L +L+ G H ++ V M
Sbjct: 278 AQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQV--DMA 335
Query: 471 QDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVL---DDQYTSSSGAKF 527
V GM YLE ++IHRDLAARN LV E + KV+DFG+AR +D Y S K
Sbjct: 336 AQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKL 395
Query: 528 PVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQP 587
PVKW PE ++FS KSDVWSFG+L++E+ T G+MP+ T +V+ M+ + +RL QP
Sbjct: 396 PVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQP 455
Query: 588 KLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEETF 629
Y +ML CW +P+ RP+FE L +++ E + ++
Sbjct: 456 SNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSY 497
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 278 bits (711), Expect = 1e-74
Identities = 171/462 (37%), Positives = 239/462 (51%), Gaps = 19/462 (4%)
Query: 168 PPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRAR-DKYGNE 226
P P +P E ++ +A+YDF A G +L + RG LE+ + + R +
Sbjct: 40 PVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSA 99
Query: 227 GYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKE-GGFMVRDS-SQPGLYTVS 284
G +P +V L WY ++R++A+QLL S E G F++R S S G Y++S
Sbjct: 100 GLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLS 159
Query: 285 LYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYP 344
+ + HY + + + YL + F + E++ Y+K N + L P
Sbjct: 160 V------RAQAKVCHYRV--SMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQP 211
Query: 345 VSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGA 404
+ AP + WE SE R+LG G FG V G W VAIK I+
Sbjct: 212 CMPQ--KAPRQ-----DVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSAN 264
Query: 405 MCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR- 463
M D +E + + L H +L++L+ VC+ +P+YIVTE M +G L FL +G R
Sbjct: 265 MKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRL 324
Query: 464 DVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSS 523
LL V EGM YLE +HRDLAARN LV + KV+DFG+AR + DD Y+ SS
Sbjct: 325 PPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSS 384
Query: 524 GAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHR 583
+K PVKW PE NY FS KSDVWSFGVL+ EVFT G+ P+E TN+E + + RG+R
Sbjct: 385 SSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYR 444
Query: 584 LYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVEC 625
L +P VY +ML CW+ PE RPSF L + + C
Sbjct: 445 LPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAIHRC 486
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 274 bits (701), Expect = 2e-73
Identities = 171/446 (38%), Positives = 245/446 (54%), Gaps = 25/446 (5%)
Query: 185 VAMYDFQAAEGHDLRLERGQEYLILE-KNDVHWWRARDKYGNEGYIPSNYVTG----KKS 239
+A Y+F DL +G I+ D +W++A++K G EG IP+NYV K
Sbjct: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
Query: 240 NNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQ-PGLYTVSLYTKFGGEGSSGFR 298
L W+ + R +AE+LL + G F+VR+S+ PG YT+ +
Sbjct: 75 TKLSLMPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLCVSC------DGKVE 127
Query: 299 HYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGF 358
HY I + K + E+ F ++ +++E++ +A GL TRL P ++G A F
Sbjct: 128 HYRIMYHAS---KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDE-F 183
Query: 359 SYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMM 418
W +N EL ++ +G G FG V LG +R KVA+K I+ A + F+ EA VM
Sbjct: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQA-FLAEASVMT 241
Query: 419 KLTHPKLVQLYGVCTQQKP-IYIVTEFMERGCLLNFLRQR-QGHFSRDVLLSMCQDVCEG 476
+L H LVQL GV ++K +YIVTE+M +G L+++LR R + D LL DVCE
Sbjct: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301
Query: 477 MEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEV 536
MEYLE N+F+HRDLAARN LVSE V KVSDFG+ + Q T K PVKW PE
Sbjct: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEA 357
Query: 537 FNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYE 596
+FS+KSDVWSFG+L+WE+++ GR+P+ + +VV V +G+++ P VYE
Sbjct: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE 417
Query: 597 VMLRCWQEKPEGRPSFEDLLRTIDEL 622
VM CW RPSF L ++ +
Sbjct: 418 VMKNCWHLDAAMRPSFLQLREQLEHI 443
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.416
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,751,881
Number of Sequences: 37866
Number of extensions: 1229617
Number of successful extensions: 7078
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 683
Number of HSP's successfully gapped in prelim test: 327
Number of HSP's that attempted gapping in prelim test: 4679
Number of HSP's gapped (non-prelim): 1437
length of query: 631
length of database: 18,247,518
effective HSP length: 108
effective length of query: 523
effective length of database: 14,157,990
effective search space: 7404628770
effective search space used: 7404628770
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.