Guide to the Human Genome
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Search of human proteins with 130977759

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|130977759 tec protein tyrosine kinase [Homo sapiens]
         (631 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|130977759 tec protein tyrosine kinase [Homo sapiens]              1309   0.0  
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                758   0.0  
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]   714   0.0  
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       614   e-176
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]            608   e-174
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]           608   e-174
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   337   2e-92
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   337   2e-92
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             332   6e-91
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               332   6e-91
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             332   6e-91
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             332   6e-91
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             332   6e-91
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]     325   6e-89
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                 323   4e-88
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   322   5e-88
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   322   5e-88
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...   321   1e-87
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...   321   1e-87
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       321   1e-87
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      320   3e-87
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              320   3e-87
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   315   6e-86
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...   314   1e-85
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   309   6e-84
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   309   6e-84
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...   309   6e-84
gi|4503787 fyn-related kinase [Homo sapiens]                          304   2e-82
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   278   1e-74
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     274   2e-73

>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score = 1309 bits (3387), Expect = 0.0
 Identities = 631/631 (100%), Positives = 631/631 (100%)

Query: 1   MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK 60
           MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK
Sbjct: 1   MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK 60

Query: 61  CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY 120
           CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY
Sbjct: 61  CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY 120

Query: 121 HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS 180
           HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS
Sbjct: 121 HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS 180

Query: 181 EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN 240
           EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN
Sbjct: 181 EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN 240

Query: 241 NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY 300
           NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY
Sbjct: 241 NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY 300

Query: 301 HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY 360
           HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY
Sbjct: 301 HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY 360

Query: 361 EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL 420
           EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL
Sbjct: 361 EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL 420

Query: 421 THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL 480
           THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL
Sbjct: 421 THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL 480

Query: 481 ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS 540
           ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS
Sbjct: 481 ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS 540

Query: 541 RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR 600
           RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR
Sbjct: 541 RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR 600

Query: 601 CWQEKPEGRPSFEDLLRTIDELVECEETFGR 631
           CWQEKPEGRPSFEDLLRTIDELVECEETFGR
Sbjct: 601 CWQEKPEGRPSFEDLLRTIDELVECEETFGR 631


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  758 bits (1956), Expect = 0.0
 Identities = 366/626 (58%), Positives = 469/626 (74%), Gaps = 11/626 (1%)

Query: 1   MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGR-AEKKYRKGFIDVSKI 59
           MN   +LEE LIK+SQQK++TSP N+K R FVLTK+ L Y+E R  +K+  KG I++S+I
Sbjct: 1   MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI 60

Query: 60  KCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIK 119
           KCVEIVK+D   IPC  KYPFQVVHD   LY+FAP  +SR  WV  LKEE +NNN+++ K
Sbjct: 61  KCVEIVKSDIS-IPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPK 119

Query: 120 YHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDN 179
           YHP FW DG ++CC Q EKLA GC +Y+  +++ +K LPP PE  +R      PL E + 
Sbjct: 120 YHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRR------PLWEPE- 172

Query: 180 SEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKS 239
            E +V+A+YD+Q  +  +L L R +EY +L+ +++HWWR +D+ G+EGY+PS+Y+  K  
Sbjct: 173 -ETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSP 231

Query: 240 NNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTK-FGGEGSSGFR 298
           NNL+ YEWY ++++R KAE+LL    KEG FMVRDS   G YTVS++TK    E +   +
Sbjct: 232 NNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIK 291

Query: 299 HYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGF 358
           HYHIKET  +PK+YY+AEK+ F SIP +I YH+HN  GLVTRLRYPV    + AP TAG 
Sbjct: 292 HYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGL 351

Query: 359 SYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMM 418
            Y KW I+PSELTF++E+GSG FG+V LG W  + KVAIK IREGAM EEDFIEEA+VMM
Sbjct: 352 RYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMM 411

Query: 419 KLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGME 478
           KL+HPKLVQLYGVC +Q PI +V EFME GCL ++LR ++G F+ + LL MC DVCEGM 
Sbjct: 412 KLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMA 471

Query: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
           YLE    IHRDLAARNCLV E  V+KVSDFGM R+VLDDQYTSS+G KFPVKW  PEVF+
Sbjct: 472 YLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFS 531

Query: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
           +SR+SSKSDVWSFGVLMWEVF+EG++P+E  +N EVV  ++ G RLY+P+LAS +VY++M
Sbjct: 532 FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIM 591

Query: 599 LRCWQEKPEGRPSFEDLLRTIDELVE 624
             CW+E+PE RP+F  LLR + E+ E
Sbjct: 592 NHCWKERPEDRPAFSRLLRQLAEIAE 617


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score =  714 bits (1843), Expect = 0.0
 Identities = 354/657 (53%), Positives = 468/657 (71%), Gaps = 39/657 (5%)

Query: 6   ILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYE---GRAEKKYRKGFIDVSKIKCV 62
           ILE I +KRSQQKKKTSPLN+K+RLF+LT   L+YYE    R  +  +KG IDV KI CV
Sbjct: 5   ILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCV 64

Query: 63  EIV---KND--DGVIPCQNK---------------YPFQVVHDANTLYIFAPSPQSRDLW 102
           E V   KN   +  IP + +               YPFQVV+D   LY+F+P+ + R  W
Sbjct: 65  ETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRW 124

Query: 103 VKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIR-------- 154
           + +LK  I+ N++++ KYHP FW DG Y CC QT K A GC+       S++        
Sbjct: 125 IHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKT 184

Query: 155 -KALPPAPETKK--RRPPPPIPLEEEDNSEEI--VVAMYDFQAAEGHDLRLERGQEYLIL 209
            K LPP PE  +  ++P PP P     ++ E+  VVA+YD+     +DL+L +G EY IL
Sbjct: 185 KKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFIL 244

Query: 210 EKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGG 269
           E++++ WWRARDK G EGYIPSNYVT +  ++++ YEWY ++M RS+AEQLL+ E KEGG
Sbjct: 245 EESNLPWWRARDKNGQEGYIPSNYVT-EAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGG 303

Query: 270 FMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEY 329
           F+VRDSS+ G YTVS++ K  G+     RHY +  T  S  +YYLAEKH F +IPE+I Y
Sbjct: 304 FIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQS--QYYLAEKHLFSTIPELINY 361

Query: 330 HKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKW 389
           H+HN+AGL++RL+YPVS + KNAP+TAG  Y  WEI+P +LTF++ELG+G FGVV+ GKW
Sbjct: 362 HQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW 421

Query: 390 RAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGC 449
           R QY VAIK I+EG+M E++FIEEAKVMM L+H KLVQLYGVCT+Q+PI+I+TE+M  GC
Sbjct: 422 RGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGC 481

Query: 450 LLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFG 509
           LLN+LR+ +  F    LL MC+DVCE MEYLE   F+HRDLAARNCLV++ GVVKVSDFG
Sbjct: 482 LLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFG 541

Query: 510 MARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKY 569
           ++RYVLDD+YTSS G+KFPV+W PPEV  YS+FSSKSD+W+FGVLMWE+++ G+MP+E++
Sbjct: 542 LSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERF 601

Query: 570 TNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECE 626
           TN E    + +G RLY+P LAS  VY +M  CW EK + RP+F+ LL  I ++++ E
Sbjct: 602 TNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEE 658


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  614 bits (1584), Expect = e-176
 Identities = 290/463 (62%), Positives = 359/463 (77%), Gaps = 2/463 (0%)

Query: 162 ETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD 221
           +  KR+P PP+P  E    +  V A+YDF   E  +L L R +EYLILEK + HWW+ARD
Sbjct: 65  QPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARD 124

Query: 222 KYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLY 281
           + GNEG IPSNYVT  K  NL+ YEWY RN+ R++AE LLR E KEG F+VRDS   G Y
Sbjct: 125 RLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSY 184

Query: 282 TVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRL 341
           T+S++        +  +HY IK+  +   ++Y+AE+HAF SIPE+I YH+HNAAGL+TRL
Sbjct: 185 TISVFMGARRSTEAAIKHYQIKKNDSG--QWYVAERHAFQSIPELIWYHQHNAAGLMTRL 242

Query: 342 RYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIR 401
           RYPV + G   P TAGFSYEKWEI+PSEL F++E+GSG FGVV LG+WR+  +VAIKAI 
Sbjct: 243 RYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAIN 302

Query: 402 EGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHF 461
           EG+M EEDFIEEAKVMMKL+H KLVQLYGVC Q+KP+YIVTEFME GCLLN+LR+ +G  
Sbjct: 303 EGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKL 362

Query: 462 SRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTS 521
            +++LLS+CQD+CEGMEYLERN +IHRDLAARNCLVS   +VK+SDFGM RYVLDD+Y S
Sbjct: 363 RKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVS 422

Query: 522 SSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRG 581
           S GAKFP+KW PPEVF ++++SSKSDVWSFGVLMWEVFTEG+MPFE  +N +VV  ++ G
Sbjct: 423 SFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEG 482

Query: 582 HRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVE 624
            RLY+P LA   +YEVM  CW EKPEGRP+F +LLR + E+ E
Sbjct: 483 FRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAE 525


>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  608 bits (1567), Expect = e-174
 Identities = 313/675 (46%), Positives = 430/675 (63%), Gaps = 55/675 (8%)

Query: 1   MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYE-GRAEKKYRKGFIDVSKI 59
           M+  +ILEE+L+KRSQQKKK SP NYKERLFVLTK+ L+YYE  + ++  RKG I++ KI
Sbjct: 1   MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI 60

Query: 60  KCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIK 119
           +CVE V  ++   P + +YPFQ+V+    LY++A + +SR  W+K L++EI+ N ++++K
Sbjct: 61  RCVEKVNLEEQT-PVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVK 119

Query: 120 YHPKFWTDGSYQCCRQTEKLAPGC---------------EKYNL--FESSIRKALPPAPE 162
           YH  F+ DG + CC+Q+ K APGC               EK+ +  F   + K     P 
Sbjct: 120 YHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPV 179

Query: 163 TKKRRPPPPIPLEEEDN-----------SEEIVVAMYDFQAAEGHDLRLERGQEYLILEK 211
            K   P     L + DN           S    +A YD  + + +  +     +Y+  E 
Sbjct: 180 LKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPRE- 238

Query: 212 NDVHWWRARD----------KYGNEGYIPSNYVTGKKS------------NNLDQYEWYC 249
           +   WW+ R              N+     N+ T K S             NLD Y+W+ 
Sbjct: 239 DFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFA 298

Query: 250 RNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSP 309
            N++RS++EQLLR + KEG FMVR+SSQ G+YTVSL++K   +     +HYH+   T + 
Sbjct: 299 GNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVH--TNAE 356

Query: 310 KKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSE 369
            K YLAE + F SIP++I YH+HN+AG++TRLR+PVS K    P +       WE+   E
Sbjct: 357 NKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREE 416

Query: 370 LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLY 429
           +T ++ELGSG FGVV+LGKW+ QY VA+K I+EG+M E++F +EA+ MMKL+HPKLV+ Y
Sbjct: 417 ITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFY 476

Query: 430 GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRD 489
           GVC+++ PIYIVTE++  GCLLN+LR          LL MC DVCEGM +LE + FIHRD
Sbjct: 477 GVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRD 536

Query: 490 LAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW 549
           LAARNCLV     VKVSDFGM RYVLDDQY SS G KFPVKW  PEVF+Y ++SSKSDVW
Sbjct: 537 LAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVW 596

Query: 550 SFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGR 609
           +FG+LMWEVF+ G+ P++ Y N +VV  V++GHRLY+P LAS+ +Y++M  CW E PE R
Sbjct: 597 AFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKR 656

Query: 610 PSFEDLLRTIDELVE 624
           P+F+ LL +I+ L E
Sbjct: 657 PTFQQLLSSIEPLRE 671


>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
          Length = 675

 Score =  608 bits (1567), Expect = e-174
 Identities = 313/675 (46%), Positives = 430/675 (63%), Gaps = 55/675 (8%)

Query: 1   MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYE-GRAEKKYRKGFIDVSKI 59
           M+  +ILEE+L+KRSQQKKK SP NYKERLFVLTK+ L+YYE  + ++  RKG I++ KI
Sbjct: 1   MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI 60

Query: 60  KCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIK 119
           +CVE V  ++   P + +YPFQ+V+    LY++A + +SR  W+K L++EI+ N ++++K
Sbjct: 61  RCVEKVNLEEQT-PVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVK 119

Query: 120 YHPKFWTDGSYQCCRQTEKLAPGC---------------EKYNL--FESSIRKALPPAPE 162
           YH  F+ DG + CC+Q+ K APGC               EK+ +  F   + K     P 
Sbjct: 120 YHSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPV 179

Query: 163 TKKRRPPPPIPLEEEDN-----------SEEIVVAMYDFQAAEGHDLRLERGQEYLILEK 211
            K   P     L + DN           S    +A YD  + + +  +     +Y+  E 
Sbjct: 180 LKMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPRE- 238

Query: 212 NDVHWWRARD----------KYGNEGYIPSNYVTGKKS------------NNLDQYEWYC 249
           +   WW+ R              N+     N+ T K S             NLD Y+W+ 
Sbjct: 239 DFPDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFA 298

Query: 250 RNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSP 309
            N++RS++EQLLR + KEG FMVR+SSQ G+YTVSL++K   +     +HYH+   T + 
Sbjct: 299 GNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVH--TNAE 356

Query: 310 KKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSE 369
            K YLAE + F SIP++I YH+HN+AG++TRLR+PVS K    P +       WE+   E
Sbjct: 357 NKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREE 416

Query: 370 LTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLY 429
           +T ++ELGSG FGVV+LGKW+ QY VA+K I+EG+M E++F +EA+ MMKL+HPKLV+ Y
Sbjct: 417 ITLLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFY 476

Query: 430 GVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRD 489
           GVC+++ PIYIVTE++  GCLLN+LR          LL MC DVCEGM +LE + FIHRD
Sbjct: 477 GVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRD 536

Query: 490 LAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVW 549
           LAARNCLV     VKVSDFGM RYVLDDQY SS G KFPVKW  PEVF+Y ++SSKSDVW
Sbjct: 537 LAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVW 596

Query: 550 SFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGR 609
           +FG+LMWEVF+ G+ P++ Y N +VV  V++GHRLY+P LAS+ +Y++M  CW E PE R
Sbjct: 597 AFGILMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKR 656

Query: 610 PSFEDLLRTIDELVE 624
           P+F+ LL +I+ L E
Sbjct: 657 PTFQQLLSSIEPLRE 671


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  337 bits (865), Expect = 2e-92
 Identities = 183/453 (40%), Positives = 279/453 (61%), Gaps = 20/453 (4%)

Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
           +N   + VA+YDF A+  + L + +G++  +L  N +  W  A+ K G +G++PSNY+T 
Sbjct: 60  ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYIT- 117

Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
              N+L+++ WY   ++R+ AE LL S    G F+VR+S S PG  ++SL  ++ G    
Sbjct: 118 -PVNSLEKHSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISL--RYEG---- 169

Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
             R YH +  T S  K Y++ +  F ++ E++ +H   A GL+T L YP   + K  PT 
Sbjct: 170 --RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNK--PTV 225

Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
            G S  Y+KWE+  +++T   +LG G +G V  G W+     VA+K ++E  M  E+F++
Sbjct: 226 YGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 285

Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
           EA VM ++ HP LVQL GVCT++ P YI+TEFM  G LL++LR+  +   +  VLL M  
Sbjct: 286 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 345

Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
            +   MEYLE+ +FIHRDLAARNCLV E  +VKV+DFG++R +  D YT+ +GAKFP+KW
Sbjct: 346 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 405

Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
             PE   Y++FS KSDVW+FGVL+WE+ T G  P+      +V  ++ + +R+ +P+   
Sbjct: 406 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 465

Query: 592 NYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVE 624
             VYE+M  CWQ  P  RPSF ++ +  + + +
Sbjct: 466 EKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 498


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  337 bits (865), Expect = 2e-92
 Identities = 183/453 (40%), Positives = 279/453 (61%), Gaps = 20/453 (4%)

Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
           +N   + VA+YDF A+  + L + +G++  +L  N +  W  A+ K G +G++PSNY+T 
Sbjct: 79  ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYIT- 136

Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
              N+L+++ WY   ++R+ AE LL S    G F+VR+S S PG  ++SL  ++ G    
Sbjct: 137 -PVNSLEKHSWYHGPVSRNAAEYLL-SSGINGSFLVRESESSPGQRSISL--RYEG---- 188

Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
             R YH +  T S  K Y++ +  F ++ E++ +H   A GL+T L YP   + K  PT 
Sbjct: 189 --RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNK--PTV 244

Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
            G S  Y+KWE+  +++T   +LG G +G V  G W+     VA+K ++E  M  E+F++
Sbjct: 245 YGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLK 304

Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
           EA VM ++ HP LVQL GVCT++ P YI+TEFM  G LL++LR+  +   +  VLL M  
Sbjct: 305 EAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMAT 364

Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
            +   MEYLE+ +FIHRDLAARNCLV E  +VKV+DFG++R +  D YT+ +GAKFP+KW
Sbjct: 365 QISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKW 424

Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
             PE   Y++FS KSDVW+FGVL+WE+ T G  P+      +V  ++ + +R+ +P+   
Sbjct: 425 TAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP 484

Query: 592 NYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVE 624
             VYE+M  CWQ  P  RPSF ++ +  + + +
Sbjct: 485 EKVYELMRACWQWNPSDRPSFAEIHQAFETMFQ 517


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  332 bits (851), Expect = 6e-91
 Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)

Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
           ++   + VA+YDF A+  + L + +G++  +L  N +  W   R K G +G++PSNY+T 
Sbjct: 91  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 148

Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
              N+L+++ WY   ++RS AE LL S    G F+VR+S S PG  ++SL  ++ G    
Sbjct: 149 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 200

Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
             R YH +  TT+  K Y+  +  F ++ E++ +H   A GLVT L YP     K  PT 
Sbjct: 201 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 256

Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
            G S  ++KWE+  +++T   +LG G +G V +G W+     VA+K ++E  M  E+F++
Sbjct: 257 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 316

Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
           EA VM ++ HP LVQL GVCT + P YIVTE+M  G LL++LR+  +   +  VLL M  
Sbjct: 317 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 376

Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
            +   MEYLE+ +FIHRDLAARNCLV E  VVKV+DFG++R +  D YT+ +GAKFP+KW
Sbjct: 377 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 436

Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
             PE   Y+ FS KSDVW+FGVL+WE+ T G  P+      +V  ++ +G+R+ QP+   
Sbjct: 437 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 496

Query: 592 NYVYEVMLRCWQEKPEGRPSFED 614
             VYE+M  CW+  P  RPSF +
Sbjct: 497 PKVYELMRACWKWSPADRPSFAE 519


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  332 bits (851), Expect = 6e-91
 Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)

Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
           ++   + VA+YDF A+  + L + +G++  +L  N +  W   R K G +G++PSNY+T 
Sbjct: 106 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 163

Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
              N+L+++ WY   ++RS AE LL S    G F+VR+S S PG  ++SL  ++ G    
Sbjct: 164 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 215

Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
             R YH +  TT+  K Y+  +  F ++ E++ +H   A GLVT L YP     K  PT 
Sbjct: 216 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 271

Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
            G S  ++KWE+  +++T   +LG G +G V +G W+     VA+K ++E  M  E+F++
Sbjct: 272 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 331

Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
           EA VM ++ HP LVQL GVCT + P YIVTE+M  G LL++LR+  +   +  VLL M  
Sbjct: 332 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 391

Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
            +   MEYLE+ +FIHRDLAARNCLV E  VVKV+DFG++R +  D YT+ +GAKFP+KW
Sbjct: 392 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 451

Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
             PE   Y+ FS KSDVW+FGVL+WE+ T G  P+      +V  ++ +G+R+ QP+   
Sbjct: 452 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 511

Query: 592 NYVYEVMLRCWQEKPEGRPSFED 614
             VYE+M  CW+  P  RPSF +
Sbjct: 512 PKVYELMRACWKWSPADRPSFAE 534


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  332 bits (851), Expect = 6e-91
 Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)

Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
           ++   + VA+YDF A+  + L + +G++  +L  N +  W   R K G +G++PSNY+T 
Sbjct: 85  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 142

Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
              N+L+++ WY   ++RS AE LL S    G F+VR+S S PG  ++SL  ++ G    
Sbjct: 143 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 194

Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
             R YH +  TT+  K Y+  +  F ++ E++ +H   A GLVT L YP     K  PT 
Sbjct: 195 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 250

Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
            G S  ++KWE+  +++T   +LG G +G V +G W+     VA+K ++E  M  E+F++
Sbjct: 251 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 310

Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
           EA VM ++ HP LVQL GVCT + P YIVTE+M  G LL++LR+  +   +  VLL M  
Sbjct: 311 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 370

Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
            +   MEYLE+ +FIHRDLAARNCLV E  VVKV+DFG++R +  D YT+ +GAKFP+KW
Sbjct: 371 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 430

Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
             PE   Y+ FS KSDVW+FGVL+WE+ T G  P+      +V  ++ +G+R+ QP+   
Sbjct: 431 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 490

Query: 592 NYVYEVMLRCWQEKPEGRPSFED 614
             VYE+M  CW+  P  RPSF +
Sbjct: 491 PKVYELMRACWKWSPADRPSFAE 513


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  332 bits (851), Expect = 6e-91
 Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)

Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
           ++   + VA+YDF A+  + L + +G++  +L  N +  W   R K G +G++PSNY+T 
Sbjct: 91  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 148

Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
              N+L+++ WY   ++RS AE LL S    G F+VR+S S PG  ++SL  ++ G    
Sbjct: 149 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 200

Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
             R YH +  TT+  K Y+  +  F ++ E++ +H   A GLVT L YP     K  PT 
Sbjct: 201 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 256

Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
            G S  ++KWE+  +++T   +LG G +G V +G W+     VA+K ++E  M  E+F++
Sbjct: 257 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 316

Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
           EA VM ++ HP LVQL GVCT + P YIVTE+M  G LL++LR+  +   +  VLL M  
Sbjct: 317 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 376

Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
            +   MEYLE+ +FIHRDLAARNCLV E  VVKV+DFG++R +  D YT+ +GAKFP+KW
Sbjct: 377 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 436

Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
             PE   Y+ FS KSDVW+FGVL+WE+ T G  P+      +V  ++ +G+R+ QP+   
Sbjct: 437 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 496

Query: 592 NYVYEVMLRCWQEKPEGRPSFED 614
             VYE+M  CW+  P  RPSF +
Sbjct: 497 PKVYELMRACWKWSPADRPSFAE 519


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  332 bits (851), Expect = 6e-91
 Identities = 185/443 (41%), Positives = 272/443 (61%), Gaps = 20/443 (4%)

Query: 178 DNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKN-DVHWWRARDKYGNEGYIPSNYVTG 236
           ++   + VA+YDF A+  + L + +G++  +L  N +  W   R K G +G++PSNY+T 
Sbjct: 70  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYIT- 127

Query: 237 KKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSS 295
              N+L+++ WY   ++RS AE LL S    G F+VR+S S PG  ++SL  ++ G    
Sbjct: 128 -PVNSLEKHSWYHGPVSRSAAEYLLSSLIN-GSFLVRESESSPGQLSISL--RYEG---- 179

Query: 296 GFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTT 355
             R YH +  TT+  K Y+  +  F ++ E++ +H   A GLVT L YP     K  PT 
Sbjct: 180 --RVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNK--PTV 235

Query: 356 AGFS--YEKWEINPSELTFMRELGSGLFGVVRLGKWRA-QYKVAIKAIREGAMCEEDFIE 412
            G S  ++KWE+  +++T   +LG G +G V +G W+     VA+K ++E  M  E+F++
Sbjct: 236 YGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLK 295

Query: 413 EAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQ-RQGHFSRDVLLSMCQ 471
           EA VM ++ HP LVQL GVCT + P YIVTE+M  G LL++LR+  +   +  VLL M  
Sbjct: 296 EAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMAT 355

Query: 472 DVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKW 531
            +   MEYLE+ +FIHRDLAARNCLV E  VVKV+DFG++R +  D YT+ +GAKFP+KW
Sbjct: 356 QISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKW 415

Query: 532 CPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLAS 591
             PE   Y+ FS KSDVW+FGVL+WE+ T G  P+      +V  ++ +G+R+ QP+   
Sbjct: 416 TAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCP 475

Query: 592 NYVYEVMLRCWQEKPEGRPSFED 614
             VYE+M  CW+  P  RPSF +
Sbjct: 476 PKVYELMRACWKWSPADRPSFAE 498


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score =  325 bits (834), Expect = 6e-89
 Identities = 183/510 (35%), Positives = 292/510 (57%), Gaps = 21/510 (4%)

Query: 123 KFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEE 182
           KF   G     +     +P C  Y    +S  K   P P +     P    + E  + + 
Sbjct: 28  KFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK---PGPNSHNSNTPG---IREAGSEDI 81

Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
           IVVA+YD++A    DL  ++G + ++LE++   WW+AR      EGYIPSNYV   + ++
Sbjct: 82  IVVALYDYEAIHHEDLSFQKGDQMVVLEESG-EWWKARSLATRKEGYIPSNYVA--RVDS 138

Query: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
           L+  EW+ + ++R  AE QLL   +  G FM+RDS +  G Y++S+      +G +  +H
Sbjct: 139 LETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDT-VKH 197

Query: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
           Y I+  T     +Y++ +  F ++ E+++++K    GL  +L  P        P    + 
Sbjct: 198 YKIR--TLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKP----WE 251

Query: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419
            + WEI    L   ++LG+G FG V +  +    KVA+K ++ G+M  E F+ EA VM  
Sbjct: 252 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 311

Query: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478
           L H KLV+L+ V T++ PIYI+TEFM +G LL+FL+  +G       L+     + EGM 
Sbjct: 312 LQHDKLVKLHAVVTKE-PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370

Query: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
           ++E+ ++IHRDL A N LVS + V K++DFG+AR + D++YT+  GAKFP+KW  PE  N
Sbjct: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430

Query: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
           +  F+ KSDVWSFG+L+ E+ T GR+P+   +N EV+  + RG+R+ +P+     +Y +M
Sbjct: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIM 490

Query: 599 LRCWQEKPEGRPSFEDLLRTIDELVECEET 628
           +RCW+ +PE RP+FE +   +D+     E+
Sbjct: 491 MRCWKNRPEERPTFEYIQSVLDDFYTATES 520


>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score =  323 bits (827), Expect = 4e-88
 Identities = 188/476 (39%), Positives = 277/476 (58%), Gaps = 20/476 (4%)

Query: 157 LPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHW 216
           LPP        PPPP   E  D  +  VVA+YD+ A    DL++ +G++  +L K    W
Sbjct: 38  LPPLVVFNHLTPPPPD--EHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVL-KGTGDW 94

Query: 217 WRARDKY-GNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRD 274
           W AR    G EGY+PSN+V   +S  L+   W+ R+  R +AE QLL   +K G F++R+
Sbjct: 95  WLARSLVTGREGYVPSNFVARVES--LEMERWFFRSQGRKEAERQLLAPINKAGSFLIRE 152

Query: 275 S-SQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHN 333
           S +  G +++S+  K         +HY I+        YY++ +  F S+  +++++   
Sbjct: 153 SETNKGAFSLSV--KDVTTQGELIKHYKIR--CLDEGGYYISPRITFPSLQALVQHYSKK 208

Query: 334 AAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQY 393
             GL  RL  P        P    ++ ++WEI    L  +R+LGSG FG V +G ++   
Sbjct: 209 GDGLCQRLTLPCVRPAPQNP----WAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNM 264

Query: 394 KVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNF 453
           KVAIK ++EG M  E F+ EA VM  L H +LV+LY V T++ PIYIVTE+M RGCLL+F
Sbjct: 265 KVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKE-PIYIVTEYMARGCLLDF 323

Query: 454 LRQRQG-HFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMAR 512
           L+  +G   S   L+ M   + EGM Y+ER + IHRDL A N LVSEA   K++DFG+AR
Sbjct: 324 LKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLAR 383

Query: 513 YVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNY 572
            ++D +YT+  GAKFP+KW  PE  ++  F+ K+DVWSFGVL+ EV T GR+P+   +N 
Sbjct: 384 -IIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNP 442

Query: 573 EVVTMVTRGHRLYQPKLASNYVYE-VMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
           EV+  + RG+R+ +P      +Y  V+  CW+ +PE RP+FE L   +++     E
Sbjct: 443 EVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATE 498


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  322 bits (826), Expect = 5e-88
 Identities = 174/441 (39%), Positives = 266/441 (60%), Gaps = 13/441 (2%)

Query: 185 VAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNNLD 243
           VA+YD+++    DL  ++G+   I+   +  WW A     G  GYIPSNYV    S+++ 
Sbjct: 90  VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA--PSDSIQ 147

Query: 244 QYEWYCRNMNRSKAEQLL-RSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRHYH 301
             EWY   + R ++E+LL  +E+  G F+VR+S +  G Y +S+ + F        +HY 
Sbjct: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV-SDFDNAKGLNVKHYK 206

Query: 302 IKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYE 361
           I++  +    +Y+  +  F S+ +++ Y+  +A GL  RL    +V   + P T G + +
Sbjct: 207 IRKLDSGG--FYITSRTQFNSLQQLVAYYSKHADGLCHRL---TTVCPTSKPQTQGLAKD 261

Query: 362 KWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLT 421
            WEI    L    +LG G FG V +G W    +VAIK ++ G M  E F++EA+VM KL 
Sbjct: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 321

Query: 422 HPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGMEYL 480
           H KLVQLY V +++ PIYIVTE+M +G LL+FL+   G + R   L+ M   +  GM Y+
Sbjct: 322 HEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380

Query: 481 ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS 540
           ER +++HRDL A N LV E  V KV+DFG+AR + D++YT+  GAKFP+KW  PE   Y 
Sbjct: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440

Query: 541 RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR 600
           RF+ KSDVWSFG+L+ E+ T+GR+P+    N EV+  V RG+R+  P      ++++M +
Sbjct: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500

Query: 601 CWQEKPEGRPSFEDLLRTIDE 621
           CW+++PE RP+FE L   +++
Sbjct: 501 CWRKEPEERPTFEYLQAFLED 521


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  322 bits (826), Expect = 5e-88
 Identities = 174/441 (39%), Positives = 266/441 (60%), Gaps = 13/441 (2%)

Query: 185 VAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNNLD 243
           VA+YD+++    DL  ++G+   I+   +  WW A     G  GYIPSNYV    S+++ 
Sbjct: 90  VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA--PSDSIQ 147

Query: 244 QYEWYCRNMNRSKAEQLL-RSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRHYH 301
             EWY   + R ++E+LL  +E+  G F+VR+S +  G Y +S+ + F        +HY 
Sbjct: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV-SDFDNAKGLNVKHYK 206

Query: 302 IKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYE 361
           I++  +    +Y+  +  F S+ +++ Y+  +A GL  RL    +V   + P T G + +
Sbjct: 207 IRKLDSGG--FYITSRTQFNSLQQLVAYYSKHADGLCHRL---TTVCPTSKPQTQGLAKD 261

Query: 362 KWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLT 421
            WEI    L    +LG G FG V +G W    +VAIK ++ G M  E F++EA+VM KL 
Sbjct: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 321

Query: 422 HPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGMEYL 480
           H KLVQLY V +++ PIYIVTE+M +G LL+FL+   G + R   L+ M   +  GM Y+
Sbjct: 322 HEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380

Query: 481 ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS 540
           ER +++HRDL A N LV E  V KV+DFG+AR + D++YT+  GAKFP+KW  PE   Y 
Sbjct: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440

Query: 541 RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR 600
           RF+ KSDVWSFG+L+ E+ T+GR+P+    N EV+  V RG+R+  P      ++++M +
Sbjct: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500

Query: 601 CWQEKPEGRPSFEDLLRTIDE 621
           CW+++PE RP+FE L   +++
Sbjct: 501 CWRKEPEERPTFEYLQAFLED 521


>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  321 bits (822), Expect = 1e-87
 Identities = 169/463 (36%), Positives = 279/463 (60%), Gaps = 20/463 (4%)

Query: 169 PPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEG 227
           PP  PL++      +V+A++ ++ +   DL  E+G++  ILE++   WW+A+    G EG
Sbjct: 56  PPASPLQDN-----LVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEG 109

Query: 228 YIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSL 285
           +IP N+V   K+N+L+   W+ +N++R  AE QLL   +  G F++R+S S  G +++S+
Sbjct: 110 FIPFNFVA--KANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSV 167

Query: 286 YTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPV 345
              F        +HY I+        +Y++ +  F  + E++ ++ + + GL TRL  P 
Sbjct: 168 -RDFDQNQGEVVKHYKIRNLDNGG--FYISPRITFPGLHELVRHYTNASDGLCTRLSRPC 224

Query: 346 SVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAM 405
             +    P    +  ++WE+    L  +  LG+G FG V +G +    KVA+K++++G+M
Sbjct: 225 QTQKPQKP----WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM 280

Query: 406 CEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG-HFSRD 464
             + F+ EA +M +L H +LV+LY V TQ+ PIYI+TE+ME G L++FL+   G   + +
Sbjct: 281 SPDAFLAEANLMKQLQHQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTIN 339

Query: 465 VLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSG 524
            LL M   + EGM ++E  ++IHRDL A N LVS+    K++DFG+AR + D++YT+  G
Sbjct: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399

Query: 525 AKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRL 584
           AKFP+KW  PE  NY  F+ KSDVWSFG+L+ E+ T GR+P+   TN EV+  + RG+R+
Sbjct: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459

Query: 585 YQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
            +P      +Y++M  CW+E+PE RP+F+ L   +++     E
Sbjct: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATE 502


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  321 bits (822), Expect = 1e-87
 Identities = 169/463 (36%), Positives = 279/463 (60%), Gaps = 20/463 (4%)

Query: 169 PPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEG 227
           PP  PL++      +V+A++ ++ +   DL  E+G++  ILE++   WW+A+    G EG
Sbjct: 56  PPASPLQDN-----LVIALHSYEPSHDGDLGFEKGEQLRILEQSG-EWWKAQSLTTGQEG 109

Query: 228 YIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSL 285
           +IP N+V   K+N+L+   W+ +N++R  AE QLL   +  G F++R+S S  G +++S+
Sbjct: 110 FIPFNFVA--KANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSV 167

Query: 286 YTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPV 345
              F        +HY I+        +Y++ +  F  + E++ ++ + + GL TRL  P 
Sbjct: 168 -RDFDQNQGEVVKHYKIRNLDNGG--FYISPRITFPGLHELVRHYTNASDGLCTRLSRPC 224

Query: 346 SVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAM 405
             +    P    +  ++WE+    L  +  LG+G FG V +G +    KVA+K++++G+M
Sbjct: 225 QTQKPQKP----WWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSM 280

Query: 406 CEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG-HFSRD 464
             + F+ EA +M +L H +LV+LY V TQ+ PIYI+TE+ME G L++FL+   G   + +
Sbjct: 281 SPDAFLAEANLMKQLQHQRLVRLYAVVTQE-PIYIITEYMENGSLVDFLKTPSGIKLTIN 339

Query: 465 VLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSG 524
            LL M   + EGM ++E  ++IHRDL A N LVS+    K++DFG+AR + D++YT+  G
Sbjct: 340 KLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREG 399

Query: 525 AKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRL 584
           AKFP+KW  PE  NY  F+ KSDVWSFG+L+ E+ T GR+P+   TN EV+  + RG+R+
Sbjct: 400 AKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRM 459

Query: 585 YQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
            +P      +Y++M  CW+E+PE RP+F+ L   +++     E
Sbjct: 460 VRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATE 502


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  321 bits (822), Expect = 1e-87
 Identities = 177/452 (39%), Positives = 265/452 (58%), Gaps = 16/452 (3%)

Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
           + VA+YD++A    DL   +G+++ IL  ++  WW AR    G  GYIPSNYV    S  
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDS-- 143

Query: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
           +   EWY   + R  AE QLL   +  G F++R+S +  G Y++S+      +G    +H
Sbjct: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH-VKH 202

Query: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
           Y I++       YY+  +  F ++ ++++++   AAGL  RL  P     K  P     S
Sbjct: 203 YKIRKLDNGG--YYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCH---KGMPRLTDLS 257

Query: 360 YEK---WEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKV 416
            +    WEI    L  ++ LG+G FG V +G W    KVAIK ++ G M  E F+EEA++
Sbjct: 258 VKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQI 317

Query: 417 MMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCE 475
           M KL H KLVQLY V +++ PIYIVTE+M +G LL+FL+  +G   +   L+ M   V  
Sbjct: 318 MKKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAA 376

Query: 476 GMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPE 535
           GM Y+ER ++IHRDL + N LV    + K++DFG+AR + D++YT+  GAKFP+KW  PE
Sbjct: 377 GMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPE 436

Query: 536 VFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVY 595
              Y RF+ KSDVWSFG+L+ E+ T+GR+P+    N EV+  V RG+R+  P+     ++
Sbjct: 437 AALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLH 496

Query: 596 EVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
           E+M+ CW++ PE RP+FE L   +++     E
Sbjct: 497 ELMIHCWKKDPEERPTFEYLQSFLEDYFTATE 528


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  320 bits (819), Expect = 3e-87
 Identities = 173/449 (38%), Positives = 263/449 (58%), Gaps = 13/449 (2%)

Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
           + VA+YD++A    DL   +G+++ IL  ++  WW AR    G  GYIPSNYV    S  
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDS-- 143

Query: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
           +   EWY   + R  AE QLL   +  G F++R+S +  G Y++S+      +G    +H
Sbjct: 144 IQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDH-VKH 202

Query: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
           Y I++       YY+  +  F ++ ++++++   A GL   L     +     P T+G +
Sbjct: 203 YKIRKLDNGG--YYITTRAQFETLQQLVQHYSEKADGLCFNLTV---IASSCTPQTSGLA 257

Query: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419
            + WE+    L   ++LG G F  V LG W    KVAIK ++ G M  E F+EEA++M K
Sbjct: 258 KDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKK 317

Query: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478
           L H KLVQLY V +++ PIYIVTE+M +G LL+FL+  +G   +   L+ M   V  GM 
Sbjct: 318 LKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMA 376

Query: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
           Y+ER ++IHRDL + N LV    + K++DFG+AR + D++YT+  GAKFP+KW  PE   
Sbjct: 377 YIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 436

Query: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
           Y RF+ KSDVWSFG+L+ E+ T+GR+P+    N EV+  V RG+R+  P+     ++E+M
Sbjct: 437 YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELM 496

Query: 599 LRCWQEKPEGRPSFEDLLRTIDELVECEE 627
           + CW++ PE RP+FE L   +++     E
Sbjct: 497 IHCWKKDPEERPTFEYLQSFLEDYFTATE 525


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  320 bits (819), Expect = 3e-87
 Identities = 174/451 (38%), Positives = 269/451 (59%), Gaps = 17/451 (3%)

Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
           I VA+YD++A    DL  ++G+ + I+   +  WW AR    G  GYIPSNYV    +++
Sbjct: 95  IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVA--PADS 152

Query: 242 LDQYEWYCRNMNRSKAEQLLRSEDKEGG-FMVRDS-SQPGLYTVSL--YTKFGGEGSSGF 297
           +   EWY   M R  AE+LL +   + G F+VR+S +  G Y++S+  + +  G+     
Sbjct: 153 IQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDN---V 209

Query: 298 RHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAG 357
           +HY I++       YY+  +  F ++ ++++++  +A GL  +L    +V     P T G
Sbjct: 210 KHYKIRKLDNGG--YYITTRAQFDTLQKLVKHYTEHADGLCHKL---TTVCPTVKPQTQG 264

Query: 358 FSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVM 417
            + + WEI    L    +LG G FG V +G W    KVAIK ++ G M  E F++EA++M
Sbjct: 265 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIM 324

Query: 418 MKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEG 476
            KL H KLV LY V +++ PIYIVTEFM +G LL+FL++  G + +   L+ M   + +G
Sbjct: 325 KKLRHDKLVPLYAVVSEE-PIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADG 383

Query: 477 MEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEV 536
           M Y+ER ++IHRDL A N LV E  V K++DFG+AR + D++YT+  GAKFP+KW  PE 
Sbjct: 384 MAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEA 443

Query: 537 FNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYE 596
             Y RF+ KSDVWSFG+L  E+ T+GR+P+    N EV+  V RG+R+  P+     ++E
Sbjct: 444 ALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHE 503

Query: 597 VMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
           +M  CW++ P+ RP+FE +   +++     E
Sbjct: 504 LMNLCWKKDPDERPTFEYIQSFLEDYFTATE 534


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  315 bits (808), Expect = 6e-86
 Identities = 172/487 (35%), Positives = 283/487 (58%), Gaps = 15/487 (3%)

Query: 145 KYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQ 204
           K +L +  +     P PE++   P      ++ +   +IVVA+Y +      DL  ++G+
Sbjct: 9   KDSLSDDGVDLKTQPVPESQLL-PGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGE 67

Query: 205 EYLILEKNDVHWWRARDKYGN-EGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLR 262
           +  +LE++   WW+A+      EG+IPSNYV   K N L+  EW+ +++ R  AE QLL 
Sbjct: 68  KMKVLEEHG-EWWKAKSLLTKKEGFIPSNYVA--KLNTLETEEWFFKDITRKDAERQLLA 124

Query: 263 SEDKEGGFMVRDSSQ-PGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFG 321
             +  G F++R+S    G +++S+   F        +HY I+        YY++ +  F 
Sbjct: 125 PGNSAGAFLIRESETLKGSFSLSV-RDFDPVHGDVIKHYKIRSLDNGG--YYISPRITFP 181

Query: 322 SIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLF 381
            I ++I++++  A GL  RL           P    +  + WEI    +  ++ LG+G F
Sbjct: 182 CISDMIKHYQKQADGLCRRLEKACISPKPQKP----WDKDAWEIPRESIKLVKRLGAGQF 237

Query: 382 GVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIV 441
           G V +G +    KVA+K ++ G M  + F+EEA +M  L H KLV+LY V T+++PIYI+
Sbjct: 238 GEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYII 297

Query: 442 TEFMERGCLLNFLRQRQG-HFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEA 500
           TE+M +G LL+FL+  +G       L+     + EGM Y+ER ++IHRDL A N LVSE+
Sbjct: 298 TEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSES 357

Query: 501 GVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFT 560
            + K++DFG+AR + D++YT+  GAKFP+KW  PE  N+  F+ KSDVWSFG+L++E+ T
Sbjct: 358 LMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVT 417

Query: 561 EGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTID 620
            G++P+   TN +V+T +++G+R+ + +   + +Y++M  CW+EK E RP+F+ L   +D
Sbjct: 418 YGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLD 477

Query: 621 ELVECEE 627
           +     E
Sbjct: 478 DFYTATE 484


>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score =  314 bits (805), Expect = 1e-85
 Identities = 171/476 (35%), Positives = 279/476 (58%), Gaps = 22/476 (4%)

Query: 164 KKRRPPPPIPL--------EEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVH 215
           K++RP P   L        ++ +   +IVVA+Y +      DL  ++G++  +LE++   
Sbjct: 40  KQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHG-E 98

Query: 216 WWRARDKYGN-EGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVR 273
           WW+A+      EG+IPSNYV   K N L+  EW+ +++ R  AE QLL   +  G F++R
Sbjct: 99  WWKAKSLLTKKEGFIPSNYVA--KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIR 156

Query: 274 DSSQ-PGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKH 332
           +S    G +++S+   F        +HY I+        YY++ +  F  I ++I++++ 
Sbjct: 157 ESETLKGSFSLSV-RDFDPVHGDVIKHYKIRSLDNGG--YYISPRITFPCISDMIKHYQK 213

Query: 333 NAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQ 392
            A GL  RL           P    +  + WEI    +  ++ LG+G FG V +G +   
Sbjct: 214 QADGLCRRLEKACISPKPQKP----WDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNS 269

Query: 393 YKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLN 452
            KVA+K ++ G M  + F+EEA +M  L H KLV+LY V T+++PIYI+TE+M +G LL+
Sbjct: 270 TKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLD 329

Query: 453 FLRQRQG-HFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMA 511
           FL+  +G       L+     + EGM Y+ER ++IHRDL A N LVSE+ + K++DFG+A
Sbjct: 330 FLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLA 389

Query: 512 RYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTN 571
           R + D++YT+  GAKFP+KW  PE  N+  F+ KSDVWSFG+L++E+ T G++P+   TN
Sbjct: 390 RVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTN 449

Query: 572 YEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
            +V+T +++G+R+ + +   + +Y++M  CW+EK E RP+F+ L   +D+     E
Sbjct: 450 ADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATE 505


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  309 bits (791), Expect = 6e-84
 Identities = 174/443 (39%), Positives = 255/443 (57%), Gaps = 13/443 (2%)

Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
           + +A+YD++A    DL   +G+++ IL   +  WW AR    G  G IPSNYV    S  
Sbjct: 81  LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDS-- 138

Query: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
           +   EWY   + R  AE QLL   + +G F++R+S +  G Y++S+       G    +H
Sbjct: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH-VKH 197

Query: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
           Y I++       YY+  +  F S+ E+++++     GL   L  P ++     P T G +
Sbjct: 198 YKIRKLDMGG--YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM---KPQTLGLA 252

Query: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419
            + WEI+ S +T  R LG+G FG V LG W    KVA+K ++ G M  + F+EEA+VM  
Sbjct: 253 KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKL 312

Query: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478
           L H KLVQLY V +++ PIYIVTEFM  G LL+FL+  +G   R   L+ M   V EGM 
Sbjct: 313 LRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371

Query: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
           Y+ER ++IHRDL A N LV E    K++DFG+AR + DD+Y    G+KFP+KW  PE   
Sbjct: 372 YMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAAL 431

Query: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
           + RF+ KSDVWSFG+L+ E+ T+GR+P+      EV+  V +G+ +  P      +YE M
Sbjct: 432 FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAM 491

Query: 599 LRCWQEKPEGRPSFEDLLRTIDE 621
            + W+  PE RP+FE L   +++
Sbjct: 492 EQTWRLDPEERPTFEYLQSFLED 514


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  309 bits (791), Expect = 6e-84
 Identities = 174/443 (39%), Positives = 255/443 (57%), Gaps = 13/443 (2%)

Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
           + +A+YD++A    DL   +G+++ IL   +  WW AR    G  G IPSNYV    S  
Sbjct: 81  LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDS-- 138

Query: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
           +   EWY   + R  AE QLL   + +G F++R+S +  G Y++S+       G    +H
Sbjct: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH-VKH 197

Query: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
           Y I++       YY+  +  F S+ E+++++     GL   L  P ++     P T G +
Sbjct: 198 YKIRKLDMGG--YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM---KPQTLGLA 252

Query: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419
            + WEI+ S +T  R LG+G FG V LG W    KVA+K ++ G M  + F+EEA+VM  
Sbjct: 253 KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKL 312

Query: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478
           L H KLVQLY V +++ PIYIVTEFM  G LL+FL+  +G   R   L+ M   V EGM 
Sbjct: 313 LRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371

Query: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
           Y+ER ++IHRDL A N LV E    K++DFG+AR + DD+Y    G+KFP+KW  PE   
Sbjct: 372 YMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAAL 431

Query: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
           + RF+ KSDVWSFG+L+ E+ T+GR+P+      EV+  V +G+ +  P      +YE M
Sbjct: 432 FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAM 491

Query: 599 LRCWQEKPEGRPSFEDLLRTIDE 621
            + W+  PE RP+FE L   +++
Sbjct: 492 EQTWRLDPEERPTFEYLQSFLED 514


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  309 bits (791), Expect = 6e-84
 Identities = 174/443 (39%), Positives = 255/443 (57%), Gaps = 13/443 (2%)

Query: 183 IVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD-KYGNEGYIPSNYVTGKKSNN 241
           + +A+YD++A    DL   +G+++ IL   +  WW AR    G  G IPSNYV    S  
Sbjct: 81  LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDS-- 138

Query: 242 LDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGSSGFRH 299
           +   EWY   + R  AE QLL   + +G F++R+S +  G Y++S+       G    +H
Sbjct: 139 IQAEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDH-VKH 197

Query: 300 YHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFS 359
           Y I++       YY+  +  F S+ E+++++     GL   L  P ++     P T G +
Sbjct: 198 YKIRKLDMGG--YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIM---KPQTLGLA 252

Query: 360 YEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMK 419
            + WEI+ S +T  R LG+G FG V LG W    KVA+K ++ G M  + F+EEA+VM  
Sbjct: 253 KDAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKL 312

Query: 420 LTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR-DVLLSMCQDVCEGME 478
           L H KLVQLY V +++ PIYIVTEFM  G LL+FL+  +G   R   L+ M   V EGM 
Sbjct: 313 LRHDKLVQLYAVVSEE-PIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371

Query: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFN 538
           Y+ER ++IHRDL A N LV E    K++DFG+AR + DD+Y    G+KFP+KW  PE   
Sbjct: 372 YMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAAL 431

Query: 539 YSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVM 598
           + RF+ KSDVWSFG+L+ E+ T+GR+P+      EV+  V +G+ +  P      +YE M
Sbjct: 432 FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAM 491

Query: 599 LRCWQEKPEGRPSFEDLLRTIDE 621
            + W+  PE RP+FE L   +++
Sbjct: 492 EQTWRLDPEERPTFEYLQSFLED 514


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  304 bits (778), Expect = 2e-82
 Identities = 173/462 (37%), Positives = 257/462 (55%), Gaps = 29/462 (6%)

Query: 185 VAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARD----KYGN----EGYIPSNYVTG 236
           VA++D+QA    DL    G +  +L+     WW AR     + G+    +GYIPSNYV  
Sbjct: 48  VALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAE 107

Query: 237 KKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDS-SQPGLYTVSLYTKFGGEGS 294
            +S  L    W+   + RS AE QLL SE+K G F++R+S SQ G +++S+         
Sbjct: 108 DRS--LQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD------G 159

Query: 295 SGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPT 354
           +  +HY IK        ++L  +  F ++ E + ++   + GL  +L  P       AP 
Sbjct: 160 AVVKHYRIKRLDEGG--FFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPF 217

Query: 355 TAGF-SYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEE 413
              + + ++WEI+ + +  ++ LGSG FG V  G W     VA+K ++ G+M   DF+ E
Sbjct: 218 DLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLRE 277

Query: 414 AKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQG---HFSRDVLLSMC 470
           A++M  L HPKL+QLY VCT + PIYI+TE M  G L  +L+   G   H ++ V   M 
Sbjct: 278 AQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQV--DMA 335

Query: 471 QDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVL---DDQYTSSSGAKF 527
             V  GM YLE  ++IHRDLAARN LV E  + KV+DFG+AR      +D Y S    K 
Sbjct: 336 AQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKL 395

Query: 528 PVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQP 587
           PVKW  PE    ++FS KSDVWSFG+L++E+ T G+MP+   T  +V+ M+ + +RL QP
Sbjct: 396 PVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQP 455

Query: 588 KLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEETF 629
                  Y +ML CW  +P+ RP+FE L   +++  E + ++
Sbjct: 456 SNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSY 497


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  278 bits (711), Expect = 1e-74
 Identities = 171/462 (37%), Positives = 239/462 (51%), Gaps = 19/462 (4%)

Query: 168 PPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRAR-DKYGNE 226
           P P +P E      ++ +A+YDF A  G +L + RG     LE+   + +  R     + 
Sbjct: 40  PVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSA 99

Query: 227 GYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKE-GGFMVRDS-SQPGLYTVS 284
           G +P  +V       L    WY   ++R++A+QLL S   E G F++R S S  G Y++S
Sbjct: 100 GLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLS 159

Query: 285 LYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYP 344
           +         +   HY +  +  +    YL +   F  + E++ Y+K N   +   L  P
Sbjct: 160 V------RAQAKVCHYRV--SMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQP 211

Query: 345 VSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGA 404
              +   AP       + WE   SE    R+LG G FG V  G W     VAIK I+   
Sbjct: 212 CMPQ--KAPRQ-----DVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSAN 264

Query: 405 MCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSR- 463
           M   D  +E + +  L H +L++L+ VC+  +P+YIVTE M +G L  FL   +G   R 
Sbjct: 265 MKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRL 324

Query: 464 DVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSS 523
             LL     V EGM YLE    +HRDLAARN LV +    KV+DFG+AR + DD Y+ SS
Sbjct: 325 PPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSS 384

Query: 524 GAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHR 583
            +K PVKW  PE  NY  FS KSDVWSFGVL+ EVFT G+ P+E  TN+E +  + RG+R
Sbjct: 385 SSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYR 444

Query: 584 LYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVEC 625
           L +P      VY +ML CW+  PE RPSF  L   +  +  C
Sbjct: 445 LPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAIHRC 486


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  274 bits (701), Expect = 2e-73
 Identities = 171/446 (38%), Positives = 245/446 (54%), Gaps = 25/446 (5%)

Query: 185 VAMYDFQAAEGHDLRLERGQEYLILE-KNDVHWWRARDKYGNEGYIPSNYVTG----KKS 239
           +A Y+F      DL   +G    I+    D +W++A++K G EG IP+NYV      K  
Sbjct: 15  IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74

Query: 240 NNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQ-PGLYTVSLYTKFGGEGSSGFR 298
             L    W+   + R +AE+LL   +  G F+VR+S+  PG YT+ +             
Sbjct: 75  TKLSLMPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLCVSC------DGKVE 127

Query: 299 HYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGF 358
           HY I    +   K  + E+  F ++ +++E++  +A GL TRL  P  ++G  A     F
Sbjct: 128 HYRIMYHAS---KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDE-F 183

Query: 359 SYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMM 418
               W +N  EL  ++ +G G FG V LG +R   KVA+K I+  A  +  F+ EA VM 
Sbjct: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQA-FLAEASVMT 241

Query: 419 KLTHPKLVQLYGVCTQQKP-IYIVTEFMERGCLLNFLRQR-QGHFSRDVLLSMCQDVCEG 476
           +L H  LVQL GV  ++K  +YIVTE+M +G L+++LR R +     D LL    DVCE 
Sbjct: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301

Query: 477 MEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEV 536
           MEYLE N+F+HRDLAARN LVSE  V KVSDFG+ +     Q T     K PVKW  PE 
Sbjct: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEA 357

Query: 537 FNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYE 596
               +FS+KSDVWSFG+L+WE+++ GR+P+ +    +VV  V +G+++  P      VYE
Sbjct: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE 417

Query: 597 VMLRCWQEKPEGRPSFEDLLRTIDEL 622
           VM  CW      RPSF  L   ++ +
Sbjct: 418 VMKNCWHLDAAMRPSFLQLREQLEHI 443


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,751,881
Number of Sequences: 37866
Number of extensions: 1229617
Number of successful extensions: 7078
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 683
Number of HSP's successfully gapped in prelim test: 327
Number of HSP's that attempted gapping in prelim test: 4679
Number of HSP's gapped (non-prelim): 1437
length of query: 631
length of database: 18,247,518
effective HSP length: 108
effective length of query: 523
effective length of database: 14,157,990
effective search space: 7404628770
effective search space used: 7404628770
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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