Search of human proteins with 4505055

Search of human proteins with 4505055

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
         (512 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...  1048   0.0  
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   993   0.0  
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]     741   0.0  
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...   674   0.0  
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...   674   0.0  
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                 633   0.0  
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              587   e-168
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       582   e-166
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      570   e-162
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   560   e-160
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   560   e-160
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   556   e-158
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   556   e-158
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...   556   e-158
gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]      503   e-142
gi|4503787 fyn-related kinase [Homo sapiens]                          469   e-132
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   348   5e-96
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   348   5e-96
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             347   1e-95
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               347   1e-95
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             347   1e-95
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             347   1e-95
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             347   1e-95
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   347   1e-95
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]              336   3e-92
gi|148596974 TXK tyrosine kinase [Homo sapiens]                       333   2e-91
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]   322   7e-88
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]                317   2e-86
gi|130977759 tec protein tyrosine kinase [Homo sapiens]               314   1e-85
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     291   1e-78

>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score = 1048 bits (2710), Expect = 0.0
 Identities = 512/512 (100%), Positives = 512/512 (100%)

Query: 1   MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD 60
           MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
Sbjct: 1   MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD 60

Query: 61  PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK 120
           PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
Sbjct: 61  PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK 120

Query: 121 LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI 180
           LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
Sbjct: 121 LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI 180

Query: 181 KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW 240
           KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
Sbjct: 181 KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW 240

Query: 241 EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD 300
           EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
Sbjct: 241 EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD 300

Query: 301 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER 360
           KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
Sbjct: 301 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER 360

Query: 361 KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF 420
           KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
Sbjct: 361 KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF 420

Query: 421 TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW 480
           TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
Sbjct: 421 TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW 480

Query: 481 KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 512
           KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
Sbjct: 481 KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 512


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  993 bits (2568), Expect = 0.0
 Identities = 491/512 (95%), Positives = 491/512 (95%), Gaps = 21/512 (4%)

Query: 1   MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD 60
           MGCIKSKGKDSLSDDGVDLKTQPV                     PESQLLPGQRFQTKD
Sbjct: 1   MGCIKSKGKDSLSDDGVDLKTQPV---------------------PESQLLPGQRFQTKD 39

Query: 61  PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK 120
           PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
Sbjct: 40  PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK 99

Query: 121 LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI 180
           LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
Sbjct: 100 LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI 159

Query: 181 KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW 240
           KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
Sbjct: 160 KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW 219

Query: 241 EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD 300
           EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
Sbjct: 220 EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD 279

Query: 301 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER 360
           KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
Sbjct: 280 KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER 339

Query: 361 KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF 420
           KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
Sbjct: 340 KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF 399

Query: 421 TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW 480
           TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
Sbjct: 400 TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW 459

Query: 481 KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 512
           KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
Sbjct: 460 KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 491


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score =  741 bits (1913), Expect = 0.0
 Identities = 364/516 (70%), Positives = 429/516 (83%), Gaps = 15/516 (2%)

Query: 1   MGCIKSK----GKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRF 56
           MGC+KSK    G ++ S      KT+   +    +YV DPTS  +  P   +   PG R 
Sbjct: 22  MGCMKSKFLQVGGNTFS------KTETSASPHCPVYVPDPTSTIKPGPNSHNSNTPGIR- 74

Query: 57  QTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSN 116
              +   +  IVVALY Y+ IH +DLSF+KG++M VLEE GEWWKA+SL T+KEG+IPSN
Sbjct: 75  ---EAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIPSN 131

Query: 117 YVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVH 176
           YVA++++LETEEWFFK I+RKDAERQLLAPGN  G+F+IR+SET KGS+SLSVRD+DP  
Sbjct: 132 YVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQ 191

Query: 177 GDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD 236
           GD +KHYKIR+LDNGG+YISPR TF  + +++ HY+K  DGLC++L   C+S KPQKPW+
Sbjct: 192 GDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWE 251

Query: 237 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKT 296
           KDAWEIPRES+KL K+LGAGQFGEVWM  YN  TKVAVKT+KPG+MSV+AFL EAN+MKT
Sbjct: 252 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 311

Query: 297 LQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMA 356
           LQHDKLV+L+AVVT+ EPIYIITE+MAKGSLLDFLKSDEG K  LPKLIDFSAQIAEGMA
Sbjct: 312 LQHDKLVKLHAVVTK-EPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370

Query: 357 YIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 416
           +IE++NYIHRDLRAAN+LVS SL+CKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN
Sbjct: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430

Query: 417 FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIM 476
           FG FTIKSDVWSFGILL EIVTYG+IPYPG +N +V+ AL +GYRMPR ENCP+ELY+IM
Sbjct: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIM 490

Query: 477 KMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 512
             CWK + EERPTF+Y+QSVLDDFYTATE QYQQQP
Sbjct: 491 MRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 526


>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  674 bits (1739), Expect = 0.0
 Identities = 323/480 (67%), Positives = 394/480 (82%), Gaps = 14/480 (2%)

Query: 33  VRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKV 92
           VRDP    +    P S L             Q ++V+AL+ Y+  H  DL F+KGE++++
Sbjct: 44  VRDPLVTYEGSNPPASPL-------------QDNLVIALHSYEPSHDGDLGFEKGEQLRI 90

Query: 93  LEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGA 152
           LE+ GEWWKA+SL T +EGFIP N+VAK N+LE E WFFK+++RKDAERQLLAPGN+ G+
Sbjct: 91  LEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGS 150

Query: 153 FLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQ 212
           FLIRESE+  GSFSLSVRDFD   G+V+KHYKIR+LDNGG+YISPRITFP + ++++HY 
Sbjct: 151 FLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYT 210

Query: 213 KQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKV 272
             +DGLC RL + C + KPQKPW +D WE+PRE++KLV+RLGAGQFGEVWMGYYN  TKV
Sbjct: 211 NASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKV 270

Query: 273 AVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLK 332
           AVK+LK G+MS  AFL EANLMK LQH +LVRLYAVVT +EPIYIITEYM  GSL+DFLK
Sbjct: 271 AVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK 329

Query: 333 SDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI 392
           +  G K+ + KL+D +AQIAEGMA+IE +NYIHRDLRAAN+LVS++L CKIADFGLAR+I
Sbjct: 330 TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI 389

Query: 393 EDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADV 452
           EDNEYTAREGAKFPIKWTAPEAIN+G FTIKSDVWSFGILL EIVT+G+IPYPG TN +V
Sbjct: 390 EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEV 449

Query: 453 MTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 512
           +  L +GYRM R +NCP+ELY +M++CWKE+ E+RPTFDYL+SVL+DF+TATEGQYQ QP
Sbjct: 450 IQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 509


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  674 bits (1739), Expect = 0.0
 Identities = 323/480 (67%), Positives = 394/480 (82%), Gaps = 14/480 (2%)

Query: 33  VRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKV 92
           VRDP    +    P S L             Q ++V+AL+ Y+  H  DL F+KGE++++
Sbjct: 44  VRDPLVTYEGSNPPASPL-------------QDNLVIALHSYEPSHDGDLGFEKGEQLRI 90

Query: 93  LEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGA 152
           LE+ GEWWKA+SL T +EGFIP N+VAK N+LE E WFFK+++RKDAERQLLAPGN+ G+
Sbjct: 91  LEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGS 150

Query: 153 FLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQ 212
           FLIRESE+  GSFSLSVRDFD   G+V+KHYKIR+LDNGG+YISPRITFP + ++++HY 
Sbjct: 151 FLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYT 210

Query: 213 KQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKV 272
             +DGLC RL + C + KPQKPW +D WE+PRE++KLV+RLGAGQFGEVWMGYYN  TKV
Sbjct: 211 NASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKV 270

Query: 273 AVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLK 332
           AVK+LK G+MS  AFL EANLMK LQH +LVRLYAVVT +EPIYIITEYM  GSL+DFLK
Sbjct: 271 AVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLK 329

Query: 333 SDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI 392
           +  G K+ + KL+D +AQIAEGMA+IE +NYIHRDLRAAN+LVS++L CKIADFGLAR+I
Sbjct: 330 TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI 389

Query: 393 EDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADV 452
           EDNEYTAREGAKFPIKWTAPEAIN+G FTIKSDVWSFGILL EIVT+G+IPYPG TN +V
Sbjct: 390 EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEV 449

Query: 453 MTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 512
           +  L +GYRM R +NCP+ELY +M++CWKE+ E+RPTFDYL+SVL+DF+TATEGQYQ QP
Sbjct: 450 IQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP 509


>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score =  633 bits (1632), Expect = 0.0
 Identities = 312/517 (60%), Positives = 396/517 (76%), Gaps = 17/517 (3%)

Query: 1   MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD 60
           MG + SK  D         K +P++  ++  +     S + +   P   L+         
Sbjct: 1   MGLVSSKKPD---------KEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPP 51

Query: 61  PEEQGD----IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSN 116
           P+E  D     VVALY Y  ++  DL   KGEK++VL+  G+WW A+SL+T +EG++PSN
Sbjct: 52  PDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSN 111

Query: 117 YVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVH 176
           +VA++ +LE E WFF+   RK+AERQLLAP N AG+FLIRESET KG+FSLSV+D     
Sbjct: 112 FVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVT-TQ 170

Query: 177 GDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD 236
           G++IKHYKIR LD GGYYISPRITFP +  +++HY K+ DGLC+RL   C+ P PQ PW 
Sbjct: 171 GELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWA 230

Query: 237 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKT 296
           +D WEIPR+S++LV++LG+GQFGEVWMGYY N+ KVA+KTLK GTMS +AFL EAN+MK 
Sbjct: 231 QDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKA 290

Query: 297 LQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMA 356
           LQH++LVRLYAVVT+ EPIYI+TEYMA+G LLDFLK+DEG ++ LP+LID SAQIAEGMA
Sbjct: 291 LQHERLVRLYAVVTK-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMA 349

Query: 357 YIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 416
           YIER N IHRDLRAAN+LVSE+L CKIADFGLAR+I D+EYTA+EGAKFPIKWTAPEAI+
Sbjct: 350 YIERMNSIHRDLRAANILVSEALCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIH 408

Query: 417 FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELY-DI 475
           FG FTIK+DVWSFG+LL E+VTYG++PYPG +N +V+  L +GYRMPR + CP ELY  +
Sbjct: 409 FGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGV 468

Query: 476 MKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP 512
           +  CW+ + EERPTF++LQSVL+DFYTATE QY+ QP
Sbjct: 469 IAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP 505


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  587 bits (1513), Expect = e-168
 Identities = 277/445 (62%), Positives = 355/445 (79%), Gaps = 3/445 (0%)

Query: 67  IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125
           I VALY Y+    +DLSFKKGE+ +++    G+WW+A+S+ T K G+IPSNYVA  ++++
Sbjct: 95  IFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQ 154

Query: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 185
            EEW+F  + RKDAER LL PGN  G FL+RESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 155 AEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKI 214

Query: 186 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ-KPWDKDAWEIPR 244
           R LDNGGYYI+ R  F  +  ++KHY + ADGLC +L   C + KPQ +   KDAWEIPR
Sbjct: 215 RKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPR 274

Query: 245 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 304
           ES++L  +LG G FGEVWMG +N +TKVA+KTLKPGTM  +AFL+EA +MK L+HDKLV 
Sbjct: 275 ESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVP 334

Query: 305 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 364
           LYAVV+ EEPIYI+TE+M+KGSLLDFLK  +G  + LP+L+D +AQIA+GMAYIER NYI
Sbjct: 335 LYAVVS-EEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYI 393

Query: 365 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 424
           HRDLRAAN+LV E+L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA  +G FTIKS
Sbjct: 394 HRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 453

Query: 425 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 484
           DVWSFGIL  E+VT G++PYPG  N +V+  + +GYRMP  + CP+ L+++M +CWK+  
Sbjct: 454 DVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDP 513

Query: 485 EERPTFDYLQSVLDDFYTATEGQYQ 509
           +ERPTF+Y+QS L+D++TATE QYQ
Sbjct: 514 DERPTFEYIQSFLEDYFTATEPQYQ 538


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  582 bits (1500), Expect = e-166
 Identities = 281/448 (62%), Positives = 352/448 (78%), Gaps = 6/448 (1%)

Query: 67  IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125
           + VALY Y+    DDLSF KGEK ++L    G+WW+A+SL T + G+IPSNYVA +++++
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145

Query: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 185
            EEW+F  + RKDAERQLL+ GN  G FLIRESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205

Query: 186 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ----KPWDKDAWE 241
           R LDNGGYYI+ R  F  +  +++HY ++A GLC RL   C    P+        KD WE
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWE 265

Query: 242 IPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDK 301
           IPRES++L+KRLG GQFGEVWMG +N +TKVA+KTLKPGTMS ++FLEEA +MK L+HDK
Sbjct: 266 IPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDK 325

Query: 302 LVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERK 361
           LV+LYAVV+ EEPIYI+TEYM KGSLLDFLK  EG  + LP L+D +AQ+A GMAYIER 
Sbjct: 326 LVQLYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERM 384

Query: 362 NYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFT 421
           NYIHRDLR+AN+LV   L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA  +G FT
Sbjct: 385 NYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 444

Query: 422 IKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWK 481
           IKSDVWSFGILL E+VT G++PYPG  N +V+  + +GYRMP  ++CP  L+++M  CWK
Sbjct: 445 IKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWK 504

Query: 482 EKAEERPTFDYLQSVLDDFYTATEGQYQ 509
           +  EERPTF+YLQS L+D++TATE QYQ
Sbjct: 505 KDPEERPTFEYLQSFLEDYFTATEPQYQ 532


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  570 bits (1468), Expect = e-162
 Identities = 276/445 (62%), Positives = 347/445 (77%), Gaps = 3/445 (0%)

Query: 67  IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125
           + VALY Y+    DDLSF KGEK ++L    G+WW+A+SL T + G+IPSNYVA +++++
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145

Query: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 185
            EEW+F  + RKDAERQLL+ GN  G FLIRESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205

Query: 186 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPW-DKDAWEIPR 244
           R LDNGGYYI+ R  F  +  +++HY ++ADGLC  L     S  PQ     KDAWE+ R
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVAR 265

Query: 245 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 304
            S+ L K+LG G F EVW+G +N +TKVA+KTLKPGTMS ++FLEEA +MK L+HDKLV+
Sbjct: 266 RSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQ 325

Query: 305 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 364
           LYAVV+ EEPIYI+TEYM KGSLLDFLK  EG  + LP L+D +AQ+A GMAYIER NYI
Sbjct: 326 LYAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYI 384

Query: 365 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 424
           HRDLR+AN+LV   L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA  +G FTIKS
Sbjct: 385 HRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 444

Query: 425 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 484
           DVWSFGILL E+VT G++PYPG  N +V+  + +GYRMP  ++CP  L+++M  CWK+  
Sbjct: 445 DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDP 504

Query: 485 EERPTFDYLQSVLDDFYTATEGQYQ 509
           EERPTF+YLQS L+D++TATE QYQ
Sbjct: 505 EERPTFEYLQSFLEDYFTATEPQYQ 529


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  560 bits (1444), Expect = e-160
 Identities = 267/443 (60%), Positives = 346/443 (78%), Gaps = 3/443 (0%)

Query: 69  VALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLETE 127
           VALY Y+     DLSFKKGE+++++    G+WW A SL T + G+IPSNYVA  ++++ E
Sbjct: 90  VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149

Query: 128 EWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRS 187
           EW+F  ITR+++ER LL   N  G FL+RESET KG++ LSV DFD   G  +KHYKIR 
Sbjct: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209

Query: 188 LDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ-KPWDKDAWEIPRES 246
           LD+GG+YI+ R  F  +  ++ +Y K ADGLC RL   C + KPQ +   KDAWEIPRES
Sbjct: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269

Query: 247 IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY 306
           ++L  +LG G FGEVWMG +N +T+VA+KTLKPGTMS +AFL+EA +MK L+H+KLV+LY
Sbjct: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329

Query: 307 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR 366
           AVV+ EEPIYI+TEYM+KGSLLDFLK + G  + LP+L+D +AQIA GMAY+ER NY+HR
Sbjct: 330 AVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388

Query: 367 DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV 426
           DLRAAN+LV E+L+CK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA  +G FTIKSDV
Sbjct: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448

Query: 427 WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE 486
           WSFGILL E+ T G++PYPG  N +V+  + +GYRMP    CP+ L+D+M  CW+++ EE
Sbjct: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE 508

Query: 487 RPTFDYLQSVLDDFYTATEGQYQ 509
           RPTF+YLQ+ L+D++T+TE QYQ
Sbjct: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  560 bits (1444), Expect = e-160
 Identities = 267/443 (60%), Positives = 346/443 (78%), Gaps = 3/443 (0%)

Query: 69  VALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLETE 127
           VALY Y+     DLSFKKGE+++++    G+WW A SL T + G+IPSNYVA  ++++ E
Sbjct: 90  VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149

Query: 128 EWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRS 187
           EW+F  ITR+++ER LL   N  G FL+RESET KG++ LSV DFD   G  +KHYKIR 
Sbjct: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209

Query: 188 LDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ-KPWDKDAWEIPRES 246
           LD+GG+YI+ R  F  +  ++ +Y K ADGLC RL   C + KPQ +   KDAWEIPRES
Sbjct: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269

Query: 247 IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY 306
           ++L  +LG G FGEVWMG +N +T+VA+KTLKPGTMS +AFL+EA +MK L+H+KLV+LY
Sbjct: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329

Query: 307 AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR 366
           AVV+ EEPIYI+TEYM+KGSLLDFLK + G  + LP+L+D +AQIA GMAY+ER NY+HR
Sbjct: 330 AVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388

Query: 367 DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV 426
           DLRAAN+LV E+L+CK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA  +G FTIKSDV
Sbjct: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448

Query: 427 WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE 486
           WSFGILL E+ T G++PYPG  N +V+  + +GYRMP    CP+ L+D+M  CW+++ EE
Sbjct: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE 508

Query: 487 RPTFDYLQSVLDDFYTATEGQYQ 509
           RPTF+YLQ+ L+D++T+TE QYQ
Sbjct: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  556 bits (1434), Expect = e-158
 Identities = 272/445 (61%), Positives = 339/445 (76%), Gaps = 3/445 (0%)

Query: 67  IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125
           + +ALY Y+    DDL+F KGEK  +L    G+WW+A+SL + K G IPSNYVA +++++
Sbjct: 81  LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQ 140

Query: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 185
            EEW+F  I RKDAERQLL+PGN  GAFLIRESET KG++SLS+RD+D   GD +KHYKI
Sbjct: 141 AEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI 200

Query: 186 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK-PWDKDAWEIPR 244
           R LD GGYYI+ R+ F  + ++++HY +  DGLC  L   C   KPQ     KDAWEI R
Sbjct: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISR 260

Query: 245 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 304
            SI L +RLG G FG+VW+G +N STKVAVKTLKPGTMS +AFLEEA +MK L+HDKLV+
Sbjct: 261 SSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ 320

Query: 305 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 364
           LYAVV+ EEPIYI+TE+M  GSLLDFLK+ EG  + LP+L+D +AQ+AEGMAY+ER NYI
Sbjct: 321 LYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYI 379

Query: 365 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 424
           HRDLRAAN+LV E L CKIADFGLAR+I+D+EY   +G+KFPIKWTAPEA  FG FTIKS
Sbjct: 380 HRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKS 439

Query: 425 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 484
           DVWSFGILL E++T G+IPYPG    +V+  + QGY MP    CP  LY+ M+  W+   
Sbjct: 440 DVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDP 499

Query: 485 EERPTFDYLQSVLDDFYTATEGQYQ 509
           EERPTF+YLQS L+D++T+ E QYQ
Sbjct: 500 EERPTFEYLQSFLEDYFTSAEPQYQ 524


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  556 bits (1434), Expect = e-158
 Identities = 272/445 (61%), Positives = 339/445 (76%), Gaps = 3/445 (0%)

Query: 67  IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125
           + +ALY Y+    DDL+F KGEK  +L    G+WW+A+SL + K G IPSNYVA +++++
Sbjct: 81  LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQ 140

Query: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 185
            EEW+F  I RKDAERQLL+PGN  GAFLIRESET KG++SLS+RD+D   GD +KHYKI
Sbjct: 141 AEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI 200

Query: 186 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK-PWDKDAWEIPR 244
           R LD GGYYI+ R+ F  + ++++HY +  DGLC  L   C   KPQ     KDAWEI R
Sbjct: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISR 260

Query: 245 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 304
            SI L +RLG G FG+VW+G +N STKVAVKTLKPGTMS +AFLEEA +MK L+HDKLV+
Sbjct: 261 SSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ 320

Query: 305 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 364
           LYAVV+ EEPIYI+TE+M  GSLLDFLK+ EG  + LP+L+D +AQ+AEGMAY+ER NYI
Sbjct: 321 LYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYI 379

Query: 365 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 424
           HRDLRAAN+LV E L CKIADFGLAR+I+D+EY   +G+KFPIKWTAPEA  FG FTIKS
Sbjct: 380 HRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKS 439

Query: 425 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 484
           DVWSFGILL E++T G+IPYPG    +V+  + QGY MP    CP  LY+ M+  W+   
Sbjct: 440 DVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDP 499

Query: 485 EERPTFDYLQSVLDDFYTATEGQYQ 509
           EERPTF+YLQS L+D++T+ E QYQ
Sbjct: 500 EERPTFEYLQSFLEDYFTSAEPQYQ 524


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  556 bits (1434), Expect = e-158
 Identities = 272/445 (61%), Positives = 339/445 (76%), Gaps = 3/445 (0%)

Query: 67  IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125
           + +ALY Y+    DDL+F KGEK  +L    G+WW+A+SL + K G IPSNYVA +++++
Sbjct: 81  LFIALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQ 140

Query: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 185
            EEW+F  I RKDAERQLL+PGN  GAFLIRESET KG++SLS+RD+D   GD +KHYKI
Sbjct: 141 AEEWYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKI 200

Query: 186 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK-PWDKDAWEIPR 244
           R LD GGYYI+ R+ F  + ++++HY +  DGLC  L   C   KPQ     KDAWEI R
Sbjct: 201 RKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLGLAKDAWEISR 260

Query: 245 ESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVR 304
            SI L +RLG G FG+VW+G +N STKVAVKTLKPGTMS +AFLEEA +MK L+HDKLV+
Sbjct: 261 SSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQ 320

Query: 305 LYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYI 364
           LYAVV+ EEPIYI+TE+M  GSLLDFLK+ EG  + LP+L+D +AQ+AEGMAY+ER NYI
Sbjct: 321 LYAVVS-EEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYI 379

Query: 365 HRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKS 424
           HRDLRAAN+LV E L CKIADFGLAR+I+D+EY   +G+KFPIKWTAPEA  FG FTIKS
Sbjct: 380 HRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKS 439

Query: 425 DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 484
           DVWSFGILL E++T G+IPYPG    +V+  + QGY MP    CP  LY+ M+  W+   
Sbjct: 440 DVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDP 499

Query: 485 EERPTFDYLQSVLDDFYTATEGQYQ 509
           EERPTF+YLQS L+D++T+ E QYQ
Sbjct: 500 EERPTFEYLQSFLEDYFTSAEPQYQ 524


>gi|23510364 protein-tyrosine kinase fyn isoform c [Homo sapiens]
          Length = 482

 Score =  503 bits (1296), Expect = e-142
 Identities = 251/444 (56%), Positives = 316/444 (71%), Gaps = 53/444 (11%)

Query: 67  IVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEGFIPSNYVAKLNTLE 125
           + VALY Y+    DDLSF KGEK ++L    G+WW+A+SL T + G+IPSNYVA +++++
Sbjct: 86  LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQ 145

Query: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKI 185
            EEW+F  + RKDAERQLL+ GN  G FLIRESET KG++SLS+RD+D + GD +KHYKI
Sbjct: 146 AEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKI 205

Query: 186 RSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRE 245
           R LDNGGYYI+ R  F  +  +++HY                                  
Sbjct: 206 RKLDNGGYYITTRAQFETLQQLVQHYS--------------------------------- 232

Query: 246 SIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRL 305
                             G +N +TKVA+KTLKPGTMS ++FLEEA +MK L+HDKLV+L
Sbjct: 233 ------------------GTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQL 274

Query: 306 YAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIH 365
           YAVV+ EEPIYI+TEYM KGSLLDFLK  EG  + LP L+D +AQ+A GMAYIER NYIH
Sbjct: 275 YAVVS-EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIH 333

Query: 366 RDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSD 425
           RDLR+AN+LV   L+CKIADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA  +G FTIKSD
Sbjct: 334 RDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 393

Query: 426 VWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAE 485
           VWSFGILL E+VT G++PYPG  N +V+  + +GYRMP  ++CP  L+++M  CWK+  E
Sbjct: 394 VWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPE 453

Query: 486 ERPTFDYLQSVLDDFYTATEGQYQ 509
           ERPTF+YLQS L+D++TATE QYQ
Sbjct: 454 ERPTFEYLQSFLEDYFTATEPQYQ 477


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  469 bits (1206), Expect = e-132
 Identities = 240/463 (51%), Positives = 319/463 (68%), Gaps = 22/463 (4%)

Query: 62  EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEE-HGEWWKAKSLLTKKEG-------FI 113
           +  G   VAL+ Y     +DLSF+ G+K++VL+  H  WW A+ L  +++G       +I
Sbjct: 41  QRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYI 100

Query: 114 PSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFD 173
           PSNYVA+  +L+ E WFF  I R DAE+QLL   N  G+FLIRESE+ KG FSLSV D  
Sbjct: 101 PSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLD-- 158

Query: 174 PVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQK 233
              G V+KHY+I+ LD GG++++ R  F  +++ + HY K +DGLC +L K C+  +   
Sbjct: 159 ---GAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPA 215

Query: 234 PWDK-----DAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFL 288
           P+D      D WEI R SI+L+KRLG+GQFGEVW G +NN+T VAVKTLKPG+M    FL
Sbjct: 216 PFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFL 275

Query: 289 EEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFS 348
            EA +MK L+H KL++LYAV T E+PIYIITE M  GSL ++L++D G K+ L + +D +
Sbjct: 276 REAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMA 335

Query: 349 AQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE-DNE--YTAREGAKF 405
           AQ+A GMAY+E +NYIHRDL A NVLV E  + K+ADFGLARV + DNE  Y +R   K 
Sbjct: 336 AQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKL 395

Query: 406 PIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRV 465
           P+KWTAPEAI    F+IKSDVWSFGILLYEI+TYGK+PY G T A V+  L+Q YR+P+ 
Sbjct: 396 PVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQP 455

Query: 466 ENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQY 508
            NCP + Y+IM  CW  + +ERPTF+ L+  L+D++  T+  Y
Sbjct: 456 SNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYF-ETDSSY 497


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  348 bits (894), Expect = 5e-96
 Identities = 188/449 (41%), Positives = 278/449 (61%), Gaps = 20/449 (4%)

Query: 62  EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 119
           E   ++ VALY +     + LS  KGEK++VL    +GEW +A++     +G++PSNY+ 
Sbjct: 60  ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYIT 117

Query: 120 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 179
            +N+LE   W+   ++R  AE  LL+ G + G+FL+RESE+  G  S+S+R    V+   
Sbjct: 118 PVNSLEKHSWYHGPVSRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVY--- 172

Query: 180 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPW---- 235
             HY+I +  +G  Y+S    F  +++++ H+   ADGL   L     +PK  KP     
Sbjct: 173 --HYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP--APKRNKPTVYGV 228

Query: 236 --DKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 292
             + D WE+ R  I +  +LG GQ+GEV+ G +   S  VAVKTLK  TM V+ FL+EA 
Sbjct: 229 SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 288

Query: 293 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 352
           +MK ++H  LV+L  V TRE P YIITE+M  G+LLD+L+     +V    L+  + QI+
Sbjct: 289 VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS 348

Query: 353 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 412
             M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++  + YTA  GAKFPIKWTAP
Sbjct: 349 SAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 408

Query: 413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 472
           E++ +  F+IKSDVW+FG+LL+EI TYG  PYPG   + V   L + YRM R E CP+++
Sbjct: 409 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 468

Query: 473 YDIMKMCWKEKAEERPTFDYLQSVLDDFY 501
           Y++M+ CW+    +RP+F  +    +  +
Sbjct: 469 YELMRACWQWNPSDRPSFAEIHQAFETMF 497


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  348 bits (894), Expect = 5e-96
 Identities = 188/449 (41%), Positives = 278/449 (61%), Gaps = 20/449 (4%)

Query: 62  EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 119
           E   ++ VALY +     + LS  KGEK++VL    +GEW +A++     +G++PSNY+ 
Sbjct: 79  ENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT--KNGQGWVPSNYIT 136

Query: 120 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 179
            +N+LE   W+   ++R  AE  LL+ G + G+FL+RESE+  G  S+S+R    V+   
Sbjct: 137 PVNSLEKHSWYHGPVSRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVY--- 191

Query: 180 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPW---- 235
             HY+I +  +G  Y+S    F  +++++ H+   ADGL   L     +PK  KP     
Sbjct: 192 --HYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYP--APKRNKPTVYGV 247

Query: 236 --DKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 292
             + D WE+ R  I +  +LG GQ+GEV+ G +   S  VAVKTLK  TM V+ FL+EA 
Sbjct: 248 SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 307

Query: 293 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 352
           +MK ++H  LV+L  V TRE P YIITE+M  G+LLD+L+     +V    L+  + QI+
Sbjct: 308 VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS 367

Query: 353 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 412
             M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++  + YTA  GAKFPIKWTAP
Sbjct: 368 SAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 427

Query: 413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 472
           E++ +  F+IKSDVW+FG+LL+EI TYG  PYPG   + V   L + YRM R E CP+++
Sbjct: 428 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 487

Query: 473 YDIMKMCWKEKAEERPTFDYLQSVLDDFY 501
           Y++M+ CW+    +RP+F  +    +  +
Sbjct: 488 YELMRACWQWNPSDRPSFAEIHQAFETMF 516


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  347 bits (890), Expect = 1e-95
 Identities = 186/438 (42%), Positives = 272/438 (62%), Gaps = 20/438 (4%)

Query: 62  EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 119
           E   ++ VALY +     + LS  KGEK++VL   ++GEW + +S     +G++PSNY+ 
Sbjct: 91  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 148

Query: 120 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 179
            +N+LE   W+   ++R  AE  L +  N  G+FL+RESE+  G  S+S+R    V+   
Sbjct: 149 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVY--- 203

Query: 180 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD--- 236
             HY+I +  +G  Y++    F  +++++ H+   ADGL   L     +PK  KP     
Sbjct: 204 --HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP--APKCNKPTVYGV 259

Query: 237 ---KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 292
               D WE+ R  I +  +LG GQ+GEV++G +   S  VAVKTLK  TM V+ FL+EA 
Sbjct: 260 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 319

Query: 293 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 352
           +MK ++H  LV+L  V T E P YI+TEYM  G+LLD+L+     +V    L+  + QI+
Sbjct: 320 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 379

Query: 353 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 412
             M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++  + YTA  GAKFPIKWTAP
Sbjct: 380 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 439

Query: 413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 472
           E++ +  F+IKSDVW+FG+LL+EI TYG  PYPG   + V   L +GYRM + E CP ++
Sbjct: 440 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 499

Query: 473 YDIMKMCWKEKAEERPTF 490
           Y++M+ CWK    +RP+F
Sbjct: 500 YELMRACWKWSPADRPSF 517


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  347 bits (890), Expect = 1e-95
 Identities = 186/438 (42%), Positives = 272/438 (62%), Gaps = 20/438 (4%)

Query: 62  EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 119
           E   ++ VALY +     + LS  KGEK++VL   ++GEW + +S     +G++PSNY+ 
Sbjct: 106 ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 163

Query: 120 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 179
            +N+LE   W+   ++R  AE  L +  N  G+FL+RESE+  G  S+S+R    V+   
Sbjct: 164 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVY--- 218

Query: 180 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD--- 236
             HY+I +  +G  Y++    F  +++++ H+   ADGL   L     +PK  KP     
Sbjct: 219 --HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP--APKCNKPTVYGV 274

Query: 237 ---KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 292
               D WE+ R  I +  +LG GQ+GEV++G +   S  VAVKTLK  TM V+ FL+EA 
Sbjct: 275 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 334

Query: 293 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 352
           +MK ++H  LV+L  V T E P YI+TEYM  G+LLD+L+     +V    L+  + QI+
Sbjct: 335 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 394

Query: 353 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 412
             M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++  + YTA  GAKFPIKWTAP
Sbjct: 395 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 454

Query: 413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 472
           E++ +  F+IKSDVW+FG+LL+EI TYG  PYPG   + V   L +GYRM + E CP ++
Sbjct: 455 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 514

Query: 473 YDIMKMCWKEKAEERPTF 490
           Y++M+ CWK    +RP+F
Sbjct: 515 YELMRACWKWSPADRPSF 532


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  347 bits (890), Expect = 1e-95
 Identities = 186/438 (42%), Positives = 272/438 (62%), Gaps = 20/438 (4%)

Query: 62  EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 119
           E   ++ VALY +     + LS  KGEK++VL   ++GEW + +S     +G++PSNY+ 
Sbjct: 85  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 142

Query: 120 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 179
            +N+LE   W+   ++R  AE  L +  N  G+FL+RESE+  G  S+S+R    V+   
Sbjct: 143 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVY--- 197

Query: 180 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD--- 236
             HY+I +  +G  Y++    F  +++++ H+   ADGL   L     +PK  KP     
Sbjct: 198 --HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP--APKCNKPTVYGV 253

Query: 237 ---KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 292
               D WE+ R  I +  +LG GQ+GEV++G +   S  VAVKTLK  TM V+ FL+EA 
Sbjct: 254 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 313

Query: 293 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 352
           +MK ++H  LV+L  V T E P YI+TEYM  G+LLD+L+     +V    L+  + QI+
Sbjct: 314 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 373

Query: 353 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 412
             M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++  + YTA  GAKFPIKWTAP
Sbjct: 374 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 433

Query: 413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 472
           E++ +  F+IKSDVW+FG+LL+EI TYG  PYPG   + V   L +GYRM + E CP ++
Sbjct: 434 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 493

Query: 473 YDIMKMCWKEKAEERPTF 490
           Y++M+ CWK    +RP+F
Sbjct: 494 YELMRACWKWSPADRPSF 511


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  347 bits (890), Expect = 1e-95
 Identities = 186/438 (42%), Positives = 272/438 (62%), Gaps = 20/438 (4%)

Query: 62  EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 119
           E   ++ VALY +     + LS  KGEK++VL   ++GEW + +S     +G++PSNY+ 
Sbjct: 91  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 148

Query: 120 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 179
            +N+LE   W+   ++R  AE  L +  N  G+FL+RESE+  G  S+S+R    V+   
Sbjct: 149 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVY--- 203

Query: 180 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD--- 236
             HY+I +  +G  Y++    F  +++++ H+   ADGL   L     +PK  KP     
Sbjct: 204 --HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP--APKCNKPTVYGV 259

Query: 237 ---KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 292
               D WE+ R  I +  +LG GQ+GEV++G +   S  VAVKTLK  TM V+ FL+EA 
Sbjct: 260 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 319

Query: 293 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 352
           +MK ++H  LV+L  V T E P YI+TEYM  G+LLD+L+     +V    L+  + QI+
Sbjct: 320 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 379

Query: 353 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 412
             M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++  + YTA  GAKFPIKWTAP
Sbjct: 380 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 439

Query: 413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 472
           E++ +  F+IKSDVW+FG+LL+EI TYG  PYPG   + V   L +GYRM + E CP ++
Sbjct: 440 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 499

Query: 473 YDIMKMCWKEKAEERPTF 490
           Y++M+ CWK    +RP+F
Sbjct: 500 YELMRACWKWSPADRPSF 517


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  347 bits (890), Expect = 1e-95
 Identities = 186/438 (42%), Positives = 272/438 (62%), Gaps = 20/438 (4%)

Query: 62  EEQGDIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTKKEGFIPSNYVA 119
           E   ++ VALY +     + LS  KGEK++VL   ++GEW + +S     +G++PSNY+ 
Sbjct: 70  ESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRS--KNGQGWVPSNYIT 127

Query: 120 KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDV 179
            +N+LE   W+   ++R  AE  L +  N  G+FL+RESE+  G  S+S+R    V+   
Sbjct: 128 PVNSLEKHSWYHGPVSRSAAEYLLSSLIN--GSFLVRESESSPGQLSISLRYEGRVY--- 182

Query: 180 IKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWD--- 236
             HY+I +  +G  Y++    F  +++++ H+   ADGL   L     +PK  KP     
Sbjct: 183 --HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYP--APKCNKPTVYGV 238

Query: 237 ---KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNN-STKVAVKTLKPGTMSVQAFLEEAN 292
               D WE+ R  I +  +LG GQ+GEV++G +   S  VAVKTLK  TM V+ FL+EA 
Sbjct: 239 SPIHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 298

Query: 293 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 352
           +MK ++H  LV+L  V T E P YI+TEYM  G+LLD+L+     +V    L+  + QI+
Sbjct: 299 VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQIS 358

Query: 353 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 412
             M Y+E+KN+IHRDL A N LV E+ + K+ADFGL+R++  + YTA  GAKFPIKWTAP
Sbjct: 359 SAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 418

Query: 413 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 472
           E++ +  F+IKSDVW+FG+LL+EI TYG  PYPG   + V   L +GYRM + E CP ++
Sbjct: 419 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKV 478

Query: 473 YDIMKMCWKEKAEERPTF 490
           Y++M+ CWK    +RP+F
Sbjct: 479 YELMRACWKWSPADRPSF 496


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  347 bits (890), Expect = 1e-95
 Identities = 178/434 (41%), Positives = 267/434 (61%), Gaps = 11/434 (2%)

Query: 67  IVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKE-GFIPSNYVAKLN--T 123
           + +ALY +      +LS ++G+++  LEE G +  A+ L  +   G +P  +VAK +  T
Sbjct: 55  LFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPET 114

Query: 124 LETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHY 183
           L  + W+F  ++R  A++ LL+P N  GAFLIR SE+  G +SLSVR    V      HY
Sbjct: 115 LSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVC-----HY 169

Query: 184 KIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIP 243
           ++    +G  Y+     FP + +++ +Y+     +   L + C+   PQK   +D WE P
Sbjct: 170 RVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCM---PQKAPRQDVWERP 226

Query: 244 RESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLV 303
                L ++LG G FGEVW G +  S  VA+K +K   M +    +E   +K L+H++L+
Sbjct: 227 HSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLI 286

Query: 304 RLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNY 363
           RL+AV +  EP+YI+TE M KG+L  FL + EG  + LP L+ F+ Q+AEGM+Y+E +  
Sbjct: 287 RLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRV 346

Query: 364 IHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIK 423
           +HRDL A NVLV + L CK+ADFGLAR+++D+ Y+    +K P+KWTAPEA N+  F+ K
Sbjct: 347 VHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQK 406

Query: 424 SDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEK 483
           SDVWSFG+LL+E+ TYG+ PY G TN + +  + +GYR+PR   CP E+Y +M  CW+  
Sbjct: 407 SDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSS 466

Query: 484 AEERPTFDYLQSVL 497
            EERP+F  L+  L
Sbjct: 467 PEERPSFATLREKL 480


>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
          Length = 451

 Score =  336 bits (862), Expect = 3e-92
 Identities = 177/449 (39%), Positives = 272/449 (60%), Gaps = 13/449 (2%)

Query: 58  TKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKK-----EGF 112
           ++D    G   V L+ +     ++LSF+ G+   V  +  +WW A +LL +      +G+
Sbjct: 3   SRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWA-TLLDEAGGAVAQGY 61

Query: 113 IPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDF 172
           +P NY+A+  T+E+E WFF  I+R +A R+L A GN+ GAFLIR SE     + LSVRD 
Sbjct: 62  VPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDT 121

Query: 173 DPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQ 232
             V     +HYKI     G  +++  ++F  + +++ +++ Q+     RL   C   +P+
Sbjct: 122 QAV-----RHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPE 176

Query: 233 KPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLE-EA 291
                D WE PRE   L ++LG+G FGEV+ G + +  +VA+K +    +  Q  L+ E 
Sbjct: 177 PLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEI 236

Query: 292 NLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQI 351
             MK L+H  ++ LYAVV+  +P+YIITE MAKGSLL+ L+  +   + + +L+D + Q+
Sbjct: 237 QAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQV 296

Query: 352 AEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTA 411
           AEGM Y+E +NYIHRDL A N+LV E+ +CK+ DFGLAR+I+++ Y + +    P KWTA
Sbjct: 297 AEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHD-HNIPYKWTA 355

Query: 412 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDE 471
           PEA++ G ++ KSDVWSFGILL+E+ + G++PYPG +N +    +  GYRMP    CP  
Sbjct: 356 PEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPS 415

Query: 472 LYDIMKMCWKEKAEERPTFDYLQSVLDDF 500
           ++ +M  CW    E+RP F  L+  L  F
Sbjct: 416 VHKLMLTCWCRDPEQRPCFKALRERLSSF 444


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score =  333 bits (854), Expect = 2e-91
 Identities = 185/469 (39%), Positives = 281/469 (59%), Gaps = 35/469 (7%)

Query: 36  PTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEE 95
           P+  K   P+P S++   ++ Q K          ALY +    P +L+ ++ E+  +LE+
Sbjct: 66  PSKRKPLPPLPPSEVAE-EKIQVK----------ALYDFLPREPCNLALRRAEEYLILEK 114

Query: 96  HG-EWWKAKSLLTKKEGFIPSNYVA--KLNTLETEEWFFKDITRKDAERQLLAPGNSAGA 152
           +   WWKA+  L   EG IPSNYV   K+  LE  EW+ ++ITR  AE  LL   +  GA
Sbjct: 115 YNPHWWKARDRLGN-EGLIPSNYVTENKITNLEIYEWYHRNITRNQAEH-LLRQESKEGA 172

Query: 153 FLIRESETLKGSFSLSV-----RDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDM 207
           F++R+S  L GS+++SV     R  +      IKHY+I+  D+G +Y++ R  F  I ++
Sbjct: 173 FIVRDSRHL-GSYTISVFMGARRSTEAA----IKHYQIKKNDSGQWYVAERHAFQSIPEL 227

Query: 208 IKHYQKQADGLCRRLEK------ACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEV 261
           I ++Q  A GL  RL        +C+       ++K  WEI    +  +K +G+GQFG V
Sbjct: 228 IWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEK--WEIDPSELAFIKEIGSGQFGVV 285

Query: 262 WMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEY 321
            +G + +  +VA+K +  G+MS + F+EEA +M  L H KLV+LY V  + +P+YI+TE+
Sbjct: 286 HLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEF 345

Query: 322 MAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMC 381
           M  G LL++L+ ++G K+    L+     I EGM Y+ER  YIHRDL A N LVS + + 
Sbjct: 346 MENGCLLNYLRENKG-KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIV 404

Query: 382 KIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGK 441
           KI+DFG+ R + D+EY +  GAKFPIKW+ PE   F  ++ KSDVWSFG+L++E+ T GK
Sbjct: 405 KISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGK 464

Query: 442 IPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTF 490
           +P+  ++N  V+ A+S+G+R+ R    P  +Y++M  CW EK E RPTF
Sbjct: 465 MPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTF 513


>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
          Length = 659

 Score =  322 bits (824), Expect = 7e-88
 Identities = 175/441 (39%), Positives = 269/441 (60%), Gaps = 16/441 (3%)

Query: 68  VVALYPYDGIHPDDLSFKKGEKMKVLEEHG-EWWKAKSLLTKKEGFIPSNYVAKL-NTLE 125
           VVALY Y  ++ +DL  +KG++  +LEE    WW+A+     +EG+IPSNYV +  +++E
Sbjct: 219 VVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDK-NGQEGYIPSNYVTEAEDSIE 277

Query: 126 TEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGD---VIKH 182
             EW+ K +TR  AE QLL      G F++R+S    G +++SV  F    GD   VI+H
Sbjct: 278 MYEWYSKHMTRSQAE-QLLKQEGKEGGFIVRDSSKA-GKYTVSV--FAKSTGDPQGVIRH 333

Query: 183 YKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKD---- 238
           Y + S     YY++ +  F  I ++I ++Q  + GL  RL+          P        
Sbjct: 334 YVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYG 393

Query: 239 AWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQ 298
           +WEI  + +  +K LG GQFG V  G +     VA+K +K G+MS   F+EEA +M  L 
Sbjct: 394 SWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLS 453

Query: 299 HDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYI 358
           H+KLV+LY V T++ PI+IITEYMA G LL++L+ +   +    +L++    + E M Y+
Sbjct: 454 HEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEYL 512

Query: 359 ERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFG 418
           E K ++HRDL A N LV++  + K++DFGL+R + D+EYT+  G+KFP++W+ PE + + 
Sbjct: 513 ESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYS 572

Query: 419 CFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKM 478
            F+ KSD+W+FG+L++EI + GK+PY   TN++    ++QG R+ R     +++Y IM  
Sbjct: 573 KFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYS 632

Query: 479 CWKEKAEERPTFDYLQS-VLD 498
           CW EKA+ERPTF  L S +LD
Sbjct: 633 CWHEKADERPTFKILLSNILD 653


>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
          Length = 620

 Score =  317 bits (812), Expect = 2e-86
 Identities = 175/470 (37%), Positives = 271/470 (57%), Gaps = 19/470 (4%)

Query: 35  DPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLE 94
           DPT N  ++P+P +      R    +PEE   +V+ALY Y    P +L+ ++ E+  +L+
Sbjct: 147 DPTKNASKKPLPPTP--EDNRRPLWEPEET--VVIALYDYQTNDPQELALRRNEEYCLLD 202

Query: 95  EHG-EWWKAKSLLTKKEGFIPSNYVAKL--NTLETEEWFFKDITRKDAERQLLAPGNSAG 151
                WW+ +      EG++PS+Y+ +   N LET EW+ K I+R  AE+ LL  G   G
Sbjct: 203 SSEIHWWRVQDR-NGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE-G 260

Query: 152 AFLIRESETLKGSFSLSVRDFDPV--HGDVIKHYKIRSLDNGG--YYISPRITFPCISDM 207
           AF++R+S T  G++++SV     V  +   IKHY I+  ++    YY++ +  F  I  +
Sbjct: 261 AFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLL 319

Query: 208 IKHYQKQADGLCRRLEKACISPKPQKPWDKDA----WEIPRESIKLVKRLGAGQFGEVWM 263
           I ++Q    GL  RL       + + P         W I    +  V+ +G+GQFG V +
Sbjct: 320 INYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHL 379

Query: 264 GYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMA 323
           GY+ N  KVA+KT++ G MS + F+EEA +M  L H KLV+LY V   + PI ++ E+M 
Sbjct: 380 GYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFME 439

Query: 324 KGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKI 383
            G L D+L++  G       L+     + EGMAY+E    IHRDL A N LV E+ + K+
Sbjct: 440 HGCLSDYLRTQRG-LFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKV 498

Query: 384 ADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIP 443
           +DFG+ R + D++YT+  G KFP+KW +PE  +F  ++ KSDVWSFG+L++E+ + GKIP
Sbjct: 499 SDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIP 558

Query: 444 YPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYL 493
           Y  R+N++V+  +S G+R+ +       +Y IM  CWKE+ E+RP F  L
Sbjct: 559 YENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRL 608


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score =  314 bits (805), Expect = 1e-85
 Identities = 170/473 (35%), Positives = 278/473 (58%), Gaps = 15/473 (3%)

Query: 44  PVPESQLL-PGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHG-EWWK 101
           P PE++   P      ++ +   +IVVA+Y +      DL  ++G++  +LE++   WW+
Sbjct: 159 PAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWR 218

Query: 102 AKSLLTKKEGFIPSNYVA--KLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESE 159
           A+      EG+IPSNYV   K N L+  EW+ +++ R  AE QLL   +  G F++R+S 
Sbjct: 219 ARDKYGN-EGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAE-QLLRSEDKEGGFMVRDSS 276

Query: 160 TLKGSFSLSV-RDFDPVHGDVIKHYKIRSLDNGG--YYISPRITFPCISDMIKHYQKQAD 216
              G +++S+   F        +HY I+        YY++ +  F  I ++I++++  A 
Sbjct: 277 Q-PGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAA 335

Query: 217 GLCRRLEKACISPKPQKP----WDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKV 272
           GL  RL           P    +  + WEI    +  ++ LG+G FG V +G +    KV
Sbjct: 336 GLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKV 395

Query: 273 AVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLK 332
           A+K ++ G M  + F+EEA +M  L H KLV+LY V T+++PIYI+TE+M +G LL+FL+
Sbjct: 396 AIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLR 455

Query: 333 SDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVI 392
             +G       L+     + EGM Y+ER ++IHRDL A N LVSE+ + K++DFG+AR +
Sbjct: 456 QRQG-HFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYV 514

Query: 393 EDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADV 452
            D++YT+  GAKFP+KW  PE  N+  F+ KSDVWSFG+L++E+ T G++P+   TN +V
Sbjct: 515 LDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEV 574

Query: 453 MTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATE 505
           +T +++G+R+ + +   + +Y++M  CW+EK E RP+F+ L   +D+     E
Sbjct: 575 VTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  291 bits (744), Expect = 1e-78
 Identities = 174/451 (38%), Positives = 254/451 (56%), Gaps = 29/451 (6%)

Query: 65  GDIVVALYPYDGIHPDDLSFKKGEKMKVLE--EHGEWWKAKSLLTKKEGFIPSNYVAKLN 122
           G   +A Y + G    DL F KG+ + ++   +   W+KAK+ + + EG IP+NYV K  
Sbjct: 11  GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGR-EGIIPANYVQKRE 69

Query: 123 ------TLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVR-DFDPV 175
                  L    WF   ITR+ AER L  P    G FL+RES    G ++L V  D    
Sbjct: 70  GVKAGTKLSLMPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCDGKVE 127

Query: 176 HGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACI---SPKPQ 232
           H  ++ H    S+D   Y       F  +  +++HY   ADGLC RL K  +   +   Q
Sbjct: 128 HYRIMYHASKLSIDEEVY-------FENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ 180

Query: 233 KPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEAN 292
             + +  W +  + +KL++ +G G+FG+V +G Y  + KVAVK +K    + QAFL EA+
Sbjct: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEAS 238

Query: 293 LMKTLQHDKLVRLYAVVTREEP-IYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQI 351
           +M  L+H  LV+L  V+  E+  +YI+TEYMAKGSL+D+L+S     +    L+ FS  +
Sbjct: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298

Query: 352 AEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTA 411
            E M Y+E  N++HRDL A NVLVSE  + K++DFGL +     + T     K P+KWTA
Sbjct: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTA 354

Query: 412 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDE 471
           PEA+    F+ KSDVWSFGILL+EI ++G++PYP     DV+  + +GY+M   + CP  
Sbjct: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA 414

Query: 472 LYDIMKMCWKEKAEERPTFDYLQSVLDDFYT 502
           +Y++MK CW   A  RP+F  L+  L+   T
Sbjct: 415 VYEVMKNCWHLDAAMRPSFLQLREQLEHIKT 445


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,995,763
Number of Sequences: 37866
Number of extensions: 916450
Number of successful extensions: 4699
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 709
Number of HSP's successfully gapped in prelim test: 312
Number of HSP's that attempted gapping in prelim test: 2170
Number of HSP's gapped (non-prelim): 1307
length of query: 512
length of database: 18,247,518
effective HSP length: 107
effective length of query: 405
effective length of database: 14,195,856
effective search space: 5749321680
effective search space used: 5749321680
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.