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Search of human proteins with 4504867
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504867 ring finger protein 8 isoform 1 [Homo sapiens]
(485 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504867 ring finger protein 8 isoform 1 [Homo sapiens] 978 0.0
gi|34304336 ring finger protein 8 isoform 2 [Homo sapiens] 829 0.0
gi|221139761 zinc finger protein 853 [Homo sapiens] 60 6e-09
gi|169202375 PREDICTED: tripartite motif-containing protein 64B-... 60 6e-09
gi|210147600 tripartite motif-containing 64 [Homo sapiens] 59 1e-08
gi|239755486 PREDICTED: tripartite motif-containing protein 64C-... 57 5e-08
gi|239755484 PREDICTED: tripartite motif-containing protein 64C-... 57 5e-08
gi|239750044 PREDICTED: tripartite motif-containing protein 64C-... 57 5e-08
gi|239750042 PREDICTED: tripartite motif-containing protein 64C-... 57 5e-08
gi|239744355 PREDICTED: tripartite motif-containing protein 64C-... 57 5e-08
gi|239744353 PREDICTED: tripartite motif-containing protein 64C-... 57 5e-08
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 56 8e-08
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 55 1e-07
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 55 1e-07
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 55 1e-07
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 55 1e-07
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 55 1e-07
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 55 1e-07
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 55 1e-07
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 55 1e-07
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 55 1e-07
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 55 1e-07
gi|239048862 checkpoint with forkhead and ring finger domains is... 55 2e-07
gi|239048792 checkpoint with forkhead and ring finger domains is... 55 2e-07
gi|34878777 ring finger protein 20 [Homo sapiens] 55 2e-07
gi|239048909 checkpoint with forkhead and ring finger domains is... 54 3e-07
gi|239048905 checkpoint with forkhead and ring finger domains is... 54 3e-07
gi|239048907 checkpoint with forkhead and ring finger domains is... 54 3e-07
gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens] 54 4e-07
gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens] 54 4e-07
>gi|4504867 ring finger protein 8 isoform 1 [Homo sapiens]
Length = 485
Score = 978 bits (2529), Expect = 0.0
Identities = 485/485 (100%), Positives = 485/485 (100%)
Query: 1 MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS 60
MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS
Sbjct: 1 MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS 60
Query: 61 RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY 120
RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY
Sbjct: 61 RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY 120
Query: 121 EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS 180
EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS
Sbjct: 121 EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS 180
Query: 181 CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS 240
CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS
Sbjct: 181 CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS 240
Query: 241 ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC 300
ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC
Sbjct: 241 ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC 300
Query: 301 AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD 360
AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD
Sbjct: 301 AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD 360
Query: 361 FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEAVTLNCAH 420
FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEAVTLNCAH
Sbjct: 361 FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEAVTLNCAH 420
Query: 421 SFCSYCINEWMKRKIECPICRKDIKSKTYSLVLDNCINKMVNNLSSEVKERRIVLIRERK 480
SFCSYCINEWMKRKIECPICRKDIKSKTYSLVLDNCINKMVNNLSSEVKERRIVLIRERK
Sbjct: 421 SFCSYCINEWMKRKIECPICRKDIKSKTYSLVLDNCINKMVNNLSSEVKERRIVLIRERK 480
Query: 481 AKRLF 485
AKRLF
Sbjct: 481 AKRLF 485
>gi|34304336 ring finger protein 8 isoform 2 [Homo sapiens]
Length = 448
Score = 829 bits (2142), Expect = 0.0
Identities = 412/412 (100%), Positives = 412/412 (100%)
Query: 1 MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS 60
MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS
Sbjct: 1 MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMIS 60
Query: 61 RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY 120
RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY
Sbjct: 61 RNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEY 120
Query: 121 EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS 180
EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS
Sbjct: 121 EYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVS 180
Query: 181 CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS 240
CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS
Sbjct: 181 CESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSS 240
Query: 241 ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC 300
ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC
Sbjct: 241 ASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLC 300
Query: 301 AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD 360
AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD
Sbjct: 301 AEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKD 360
Query: 361 FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIE 412
FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIE
Sbjct: 361 FEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIE 412
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 59.7 bits (143), Expect = 6e-09
Identities = 43/203 (21%), Positives = 102/203 (50%), Gaps = 9/203 (4%)
Query: 194 EVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSAS--------QRS 245
E+ P + +L+ L+ K P++ +H +Q+ Q
Sbjct: 117 ELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQ 176
Query: 246 LQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQ 305
LQ + ++L+ + Q+Q++ + +++Q ++ ++++Q +++LQ Q Q EQ Q
Sbjct: 177 LQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQ 236
Query: 306 QQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAII 365
QQ ++ L++ Q ++Q LQ + ++ L+QQ AQ LQ+ L ++ ++ + ++
Sbjct: 237 QQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQ-LQQQLLLQQQEQLQQQQQQQLL 295
Query: 366 QAKNKELEQTKEEKEKMQAQKEE 388
Q + ++L+Q + + ++ ++EE
Sbjct: 296 QQQQEQLQQQQLQPPPLEPEEEE 318
Score = 46.6 bits (109), Expect = 5e-05
Identities = 34/164 (20%), Positives = 81/164 (49%), Gaps = 7/164 (4%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVV-Q 287
++ +Q Q+ Q+ + L+ ++ Q++ + + +Q Q ++++ Q
Sbjct: 222 QLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQ 281
Query: 288 MEQELQDLQSQLCAEQAQQQARVEQLE----KTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+++LQ Q Q +Q Q+Q + +QL+ + +EEE L+ + + G + +Q Q
Sbjct: 282 QQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQE 341
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
L+ L E + ++ + +Q + ++LEQ E++++ Q+E
Sbjct: 342 LERQQEL--ERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQE 383
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/195 (22%), Positives = 95/195 (48%), Gaps = 31/195 (15%)
Query: 211 EPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAV 270
EP + +P P V + A + QR LQ+ ++ + Q Q +HE +
Sbjct: 56 EPQERNSSPQRPAVS--APVGASEIAEETRPGQRELQLQQLEQQP----EPQQQPQHEQL 109
Query: 271 ------MNVKKQTQKGNSKKVVQMEQEL------QDLQSQLCAEQAQQQARVEQLEKT-- 316
+ +++Q Q+ +++ Q++QE Q+L+ +L QQQ + +Q+++
Sbjct: 110 QQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQR 169
Query: 317 FQEEEQHLQGLEIAQGEKDLKQQ--LAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQ 374
Q++++ LQ + AQ ++ L+QQ L Q +QE L ++ + +Q + +Q
Sbjct: 170 LQQQQEQLQTQQ-AQEQQVLQQQEQLQQQVQEQQLLQQQQEQ--------LQQQQLLQQQ 220
Query: 375 TKEEKEKMQAQKEEV 389
+ ++++ Q Q+E++
Sbjct: 221 EQLQQQQFQQQQEQL 235
Score = 34.3 bits (77), Expect = 0.26
Identities = 41/162 (25%), Positives = 74/162 (45%), Gaps = 27/162 (16%)
Query: 243 QRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQE-LQDLQSQ--- 298
Q+ LQ + + + L + Q Q + + ++ ++Q Q+ ++++Q +QE LQ Q Q
Sbjct: 252 QQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPP 311
Query: 299 -----------------LCAEQAQQQARVE---QLEKTFQEEEQHLQGLEIAQGEKDLKQ 338
L +EQ +Q R E Q E Q+E++ LQ L++ + + L+Q
Sbjct: 312 LEPEEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQ-LKLQEELQQLEQ 370
Query: 339 QLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKE 380
QL Q Q+ +E+ E Q + +LE T + E
Sbjct: 371 QLEQ--QQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPE 410
Score = 33.1 bits (74), Expect = 0.58
Identities = 23/83 (27%), Positives = 46/83 (55%), Gaps = 4/83 (4%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQE---E 320
Q++ E + + Q+ + +++++ELQ L+ QL +Q Q + + QLE T E +
Sbjct: 337 QQRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQ 396
Query: 321 EQHLQGLEIAQGEKDLKQQLAQA 343
+Q +Q LE+ + +L+ +L A
Sbjct: 397 QQEVQ-LELTPVQPELQLELVPA 418
>gi|169202375 PREDICTED: tripartite motif-containing protein
64B-like [Homo sapiens]
Length = 449
Score = 59.7 bits (143), Expect = 6e-09
Identities = 31/98 (31%), Positives = 53/98 (54%), Gaps = 11/98 (11%)
Query: 396 VLENELQCIICSEYFIEAVTLNCAHSFCSYCI---NEWMKRKIECPICRKDIKSKTYSLV 452
V +NEL C IC YFI+ VT++C HSFC C+ +E + + CP CRK + ++
Sbjct: 8 VFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAPMRCPSCRKTSEKPNFN-- 65
Query: 453 LDNCINKMVNNLSSEVKERRI-----VLIRERKAKRLF 485
N + K +++L+ + + + I + + + K LF
Sbjct: 66 -TNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELF 102
>gi|210147600 tripartite motif-containing 64 [Homo sapiens]
Length = 449
Score = 58.9 bits (141), Expect = 1e-08
Identities = 31/98 (31%), Positives = 53/98 (54%), Gaps = 11/98 (11%)
Query: 396 VLENELQCIICSEYFIEAVTLNCAHSFCSYCI---NEWMKRKIECPICRKDIKSKTYSLV 452
V +NEL C IC YFI+ VT++C HSFC C+ +E + + CP CRK + ++
Sbjct: 8 VFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAPMRCPSCRKISEKPNFN-- 65
Query: 453 LDNCINKMVNNLSSEVKERRI-----VLIRERKAKRLF 485
N + K +++L+ + + + I + + + K LF
Sbjct: 66 -TNVVLKKLSSLARQTRPQNINSSDNICVLHEETKELF 102
>gi|239755486 PREDICTED: tripartite motif-containing protein
64C-like isoform 2 [Homo sapiens]
Length = 447
Score = 56.6 bits (135), Expect = 5e-08
Identities = 31/98 (31%), Positives = 51/98 (52%), Gaps = 11/98 (11%)
Query: 396 VLENELQCIICSEYFIEAVTLNCAHSFCSYCI---NEWMKRKIECPICRKDIKSKTYSLV 452
V +NEL C IC YFI+ VT +C HSFC C+ +E + + CP+CRK + ++
Sbjct: 8 VFQNELICCICVNYFIDPVTTDCVHSFCRPCLCLCSEEGRAPMRCPLCRKISEKPNFN-- 65
Query: 453 LDNCINKMVNNLSSEVKERRI-----VLIRERKAKRLF 485
N K + +L+ + + + I + + + K LF
Sbjct: 66 -TNVALKKLASLARQTRPQNINSSDNICVLHEETKELF 102
>gi|239755484 PREDICTED: tripartite motif-containing protein
64C-like isoform 1 [Homo sapiens]
Length = 450
Score = 56.6 bits (135), Expect = 5e-08
Identities = 31/98 (31%), Positives = 51/98 (52%), Gaps = 11/98 (11%)
Query: 396 VLENELQCIICSEYFIEAVTLNCAHSFCSYCI---NEWMKRKIECPICRKDIKSKTYSLV 452
V +NEL C IC YFI+ VT +C HSFC C+ +E + + CP+CRK + ++
Sbjct: 8 VFQNELICCICVNYFIDPVTTDCVHSFCRPCLCLCSEEGRAPMRCPLCRKISEKPNFN-- 65
Query: 453 LDNCINKMVNNLSSEVKERRI-----VLIRERKAKRLF 485
N K + +L+ + + + I + + + K LF
Sbjct: 66 -TNVALKKLASLARQTRPQNINSSDNICVLHEETKELF 102
>gi|239750044 PREDICTED: tripartite motif-containing protein
64C-like isoform 2 [Homo sapiens]
Length = 447
Score = 56.6 bits (135), Expect = 5e-08
Identities = 31/98 (31%), Positives = 51/98 (52%), Gaps = 11/98 (11%)
Query: 396 VLENELQCIICSEYFIEAVTLNCAHSFCSYCI---NEWMKRKIECPICRKDIKSKTYSLV 452
V +NEL C IC YFI+ VT +C HSFC C+ +E + + CP+CRK + ++
Sbjct: 8 VFQNELICCICVNYFIDPVTTDCVHSFCRPCLCLCSEEGRAPMRCPLCRKISEKPNFN-- 65
Query: 453 LDNCINKMVNNLSSEVKERRI-----VLIRERKAKRLF 485
N K + +L+ + + + I + + + K LF
Sbjct: 66 -TNVALKKLASLARQTRPQNINSSDNICVLHEETKELF 102
>gi|239750042 PREDICTED: tripartite motif-containing protein
64C-like isoform 1 [Homo sapiens]
Length = 450
Score = 56.6 bits (135), Expect = 5e-08
Identities = 31/98 (31%), Positives = 51/98 (52%), Gaps = 11/98 (11%)
Query: 396 VLENELQCIICSEYFIEAVTLNCAHSFCSYCI---NEWMKRKIECPICRKDIKSKTYSLV 452
V +NEL C IC YFI+ VT +C HSFC C+ +E + + CP+CRK + ++
Sbjct: 8 VFQNELICCICVNYFIDPVTTDCVHSFCRPCLCLCSEEGRAPMRCPLCRKISEKPNFN-- 65
Query: 453 LDNCINKMVNNLSSEVKERRI-----VLIRERKAKRLF 485
N K + +L+ + + + I + + + K LF
Sbjct: 66 -TNVALKKLASLARQTRPQNINSSDNICVLHEETKELF 102
>gi|239744355 PREDICTED: tripartite motif-containing protein
64C-like isoform 1 [Homo sapiens]
Length = 447
Score = 56.6 bits (135), Expect = 5e-08
Identities = 31/98 (31%), Positives = 51/98 (52%), Gaps = 11/98 (11%)
Query: 396 VLENELQCIICSEYFIEAVTLNCAHSFCSYCI---NEWMKRKIECPICRKDIKSKTYSLV 452
V +NEL C IC YFI+ VT +C HSFC C+ +E + + CP+CRK + ++
Sbjct: 8 VFQNELICCICVNYFIDPVTTDCVHSFCRPCLCLCSEEGRAPMRCPLCRKISEKPNFN-- 65
Query: 453 LDNCINKMVNNLSSEVKERRI-----VLIRERKAKRLF 485
N K + +L+ + + + I + + + K LF
Sbjct: 66 -TNVALKKLASLARQTRPQNINSSDNICVLHEETKELF 102
>gi|239744353 PREDICTED: tripartite motif-containing protein
64C-like isoform 2 [Homo sapiens]
Length = 450
Score = 56.6 bits (135), Expect = 5e-08
Identities = 31/98 (31%), Positives = 51/98 (52%), Gaps = 11/98 (11%)
Query: 396 VLENELQCIICSEYFIEAVTLNCAHSFCSYCI---NEWMKRKIECPICRKDIKSKTYSLV 452
V +NEL C IC YFI+ VT +C HSFC C+ +E + + CP+CRK + ++
Sbjct: 8 VFQNELICCICVNYFIDPVTTDCVHSFCRPCLCLCSEEGRAPMRCPLCRKISEKPNFN-- 65
Query: 453 LDNCINKMVNNLSSEVKERRI-----VLIRERKAKRLF 485
N K + +L+ + + + I + + + K LF
Sbjct: 66 -TNVALKKLASLARQTRPQNINSSDNICVLHEETKELF 102
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 55.8 bits (133), Expect = 8e-08
Identities = 56/258 (21%), Positives = 119/258 (46%), Gaps = 24/258 (9%)
Query: 137 SPKNDQMIEKNKEL--RTKRKFSLDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKGE 194
SPK + ++ + + K DE++ + + + KV G P +Q +G
Sbjct: 344 SPKENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGKG-PSFNQERGT 402
Query: 195 VASTPSDNLDPKLTALE--PSKTTGAPIYPG-FPKVTEVHHEQKASNSSASQRSLQMFKV 251
+ P PKL A + P P PG FP +V E + Q+S V
Sbjct: 403 SSHLPPP---PKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQSEISAAV 459
Query: 252 TMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVE 311
+R + + E +++Q + ++K+ +++++L L+ Q E+ +++ R +
Sbjct: 460 ERAR--------KRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREK 511
Query: 312 QLEKTFQ-EEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
+ E+ + E+EQ + + + +++ +Q+ + L++ E+ + +K Q K K
Sbjct: 512 EREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERK------QEKEK 565
Query: 371 ELEQTKEEKEKMQAQKEE 388
ELE+ KE+++++Q KE+
Sbjct: 566 ELERQKEKEKELQKMKEQ 583
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 55.5 bits (132), Expect = 1e-07
Identities = 76/341 (22%), Positives = 144/341 (42%), Gaps = 43/341 (12%)
Query: 97 VYSIHQGDYIQLGVPLENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELR-TKRK 155
+ + +G ++ + + E + E++ET + K +++ +K KE++ T +K
Sbjct: 913 ILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKK 972
Query: 156 FSLDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKG--EVASTPSDNLDPKLTALEPS 213
LD+ A LK ++ + E Q K E+A S + ++ LE +
Sbjct: 973 KLLDQEA--------KLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETN 1024
Query: 214 KTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNV 273
+ +TEVH + S ++ L + I +IQ+QEK + V +
Sbjct: 1025 QK------EQIESLTEVHRRELNDVISIWEKKLNQQAEELQEI--HEIQLQEKEQEVAEL 1076
Query: 274 KKQ------TQKGNSKKVVQMEQE-------LQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
K++ ++ +K++ +++E L +LQ QL Q+ A V L + +
Sbjct: 1077 KQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQL----KQKSAHVNSLAQDETKL 1132
Query: 321 EQHLQGLEIAQGEKDLKQQ--LAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEE 378
+ HL+ LE+ K LK+ L + L E L EE R + + ++ ++E + K
Sbjct: 1133 KAHLEKLEV-DLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSS 1191
Query: 379 KEKMQAQKEEVLSHMNDVLEN-ELQCIIC---SEYFIEAVT 415
EK E+ + E +Q IC +E +EA T
Sbjct: 1192 HEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKT 1232
Score = 43.1 bits (100), Expect = 6e-04
Identities = 41/178 (23%), Positives = 82/178 (46%), Gaps = 10/178 (5%)
Query: 229 EVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQM 288
E H + ++R Q + R+ + ++++H+ + + K+ ++ ++
Sbjct: 1922 EAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQ 1981
Query: 289 EQELQDLQ-----SQLCAEQAQQQARVEQ-LEKTFQEEEQHLQGLEIAQGEKDLKQQLAQ 342
EQE +L+ QL E Q A+ EQ LE T +E Q +E A+ + +++ Q
Sbjct: 1982 EQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE-AELLESHQEETNQ 2040
Query: 343 ALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENE 400
L++ ++L R+ K +E I+ A+ +E+ + +Q Q EE+ LE E
Sbjct: 2041 LLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRD---LQTQLEELQKKYQQKLEQE 2095
Score = 42.0 bits (97), Expect = 0.001
Identities = 40/185 (21%), Positives = 86/185 (46%), Gaps = 22/185 (11%)
Query: 231 HHEQKASNSSASQRSLQMFKVTMSRILRLK----IQMQEKHEA---------VMNVKKQT 277
H + KA +Q ++ + RIL K ++ Q+K V ++ +Q
Sbjct: 811 HEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQL 870
Query: 278 QKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLK 337
+K NS +MEQ+++ L ++ EQ ++ E+E + L++ +G+K
Sbjct: 871 EKQNS----EMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMI--LQMREGQKKEI 924
Query: 338 QQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVL 397
+ L Q L A + ++ +++E + + K++E+ K++ ++MQ ++ L L
Sbjct: 925 EILTQKLS---AKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKL 981
Query: 398 ENELQ 402
+ EL+
Sbjct: 982 KKELE 986
Score = 40.4 bits (93), Expect = 0.004
Identities = 38/178 (21%), Positives = 92/178 (51%), Gaps = 17/178 (9%)
Query: 233 EQKASNSSAS----QRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQM 288
EQK + A+ +++L + T +LK +M E+ + + ++ + +++ ++
Sbjct: 403 EQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRV 462
Query: 289 EQELQDLQSQLCAEQAQQQARVEQL-EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEH 347
+QE+ D+ + EQ A++++L EK +EQ L ++ E++ ++Q+ AL++
Sbjct: 463 KQEVVDVMKKSSEEQI---AKLQKLHEKELARKEQELT-KKLQTREREFQEQMKVALEKS 518
Query: 348 WALMEELNRSKKDFEAIIQAKNKELEQTK-----EEKEKMQAQKEEVLSHMNDVLENE 400
+ ++++ K+ E++ +ELE K E + K++ ++E ++ +LE E
Sbjct: 519 QSEYLKISQEKEQQESLAL---EELELQKKAILTESENKLRDLQQEAETYRTRILELE 573
Score = 39.7 bits (91), Expect = 0.006
Identities = 65/364 (17%), Positives = 146/364 (40%), Gaps = 61/364 (16%)
Query: 145 EKNKELRTKRKFSLDE----LAGPGAEGPSNLKSKINKVSCESGQPVKSQGKGEVASTPS 200
+K +E R K K +DE + E +L+ ++++V E +K + ++A
Sbjct: 424 QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIA---- 479
Query: 201 DNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLK 260
K+ ++H ++ A + LQ + +++
Sbjct: 480 -------------------------KLQKLHEKELARKEQELTKKLQTREREFQEQMKVA 514
Query: 261 IQMQEKHEAVMNVKKQTQKGNS-------KKVVQMEQE--LQDLQSQLCAEQAQQQARVE 311
++ + ++ +K+ Q+ + KK + E E L+DLQ + + +
Sbjct: 515 LEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELES 574
Query: 312 QLEKTFQEEEQHLQGLEI-AQGEKDL-KQQLAQALQEHWALMEELNRSK-----KDFEAI 364
LEK+ QE + + L + + EK+ +++ +++H +E L + + + +
Sbjct: 575 SLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVL 634
Query: 365 IQAKNKELEQTKE----EKEKMQAQKEEVL-SHMNDVLENELQCIICSEYFIEAVTLNCA 419
Q E+E+ +E EKE + KE + +H+ ++ E L+ + + +E+++
Sbjct: 635 KQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLS---- 690
Query: 420 HSFCSYCINEWMKRKIECPICR--KDIKSKTYSLVLDNCINKMVNNLSSEVKERRIVLIR 477
S S + K + E + + D + +D N + S +KE + + R
Sbjct: 691 -SELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQR 749
Query: 478 ERKA 481
KA
Sbjct: 750 TEKA 753
Score = 38.9 bits (89), Expect = 0.011
Identities = 38/186 (20%), Positives = 93/186 (50%), Gaps = 20/186 (10%)
Query: 236 ASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKG---NSKKVVQMEQEL 292
A +L+M + ++++ QM + E + K+++++ +K + Q+
Sbjct: 367 AETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKT 426
Query: 293 QDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALME 352
++ + +L AE +Q ++ +EKT +EE LQ E+++ ++++ + ++ +E A ++
Sbjct: 427 EEARRKLKAEMDEQ---IKTIEKTSEEERISLQ-QELSRVKQEVVDVMKKSSEEQIAKLQ 482
Query: 353 -----ELNRSKKDFEAIIQAKNKE--------LEQTKEEKEKMQAQKEEVLSHMNDVLEN 399
EL R +++ +Q + +E LE+++ E K+ +KE+ S + LE
Sbjct: 483 KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL 542
Query: 400 ELQCII 405
+ + I+
Sbjct: 543 QKKAIL 548
Score = 38.5 bits (88), Expect = 0.014
Identities = 71/313 (22%), Positives = 131/313 (41%), Gaps = 47/313 (15%)
Query: 123 EVTEEDWETIYPCLSPKNDQMIEKNKELRTKR---KFSLDELAGPGAEGPSNLKSKINKV 179
+V ++ ++T L K +Q EK L+ K + ++E+ E ++++ +
Sbjct: 632 QVLKQQYQTEMEKLREKCEQ--EKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESL 689
Query: 180 SCESGQPVKSQGK-GEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASN 238
S E + +K++ K E S D D LE + HH+Q+ +
Sbjct: 690 SSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDE-----------QKNHHQQQVDS 738
Query: 239 SSASQR-SLQMF-KVTMSRILRLKIQMQEK------HEAVMNVKKQTQKGNSKKVVQMEQ 290
S+Q K +I +L++ ++E+ H+A + + K + ++ Q
Sbjct: 739 IIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASA 798
Query: 291 ELQDLQSQLCAEQAQQQARVEQLEKTFQ-----EEEQHLQGLEIAQGE---KDLKQQLAQ 342
+L QS A Q +A EQL + Q E E+ L ++A+ E KD+ +L
Sbjct: 799 KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDA 858
Query: 343 ALQEHWALMEELNRSKKD-----------FEAIIQAKNKELEQTKE---EKEKMQAQKEE 388
+ LM++L + + +E+ ++ NKE EQTK+ EKE M Q E
Sbjct: 859 HKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMRE 918
Query: 389 VLSHMNDVLENEL 401
++L +L
Sbjct: 919 GQKKEIEILTQKL 931
Score = 38.1 bits (87), Expect = 0.018
Identities = 43/228 (18%), Positives = 95/228 (41%), Gaps = 37/228 (16%)
Query: 201 DNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLK 260
+ LD K T LE + +V + H+ + S ++ +M + +++ K
Sbjct: 677 EKLDVKQTELESLSSE-------LSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQK 729
Query: 261 IQMQEKHEAVMNVKK----QTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKT 316
Q++ ++++ + +T+K ++ Q+E L++ L + QA VE LE
Sbjct: 730 NHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHL----KEHQAHVENLEAD 785
Query: 317 FQEEEQHLQG----LEIAQGEKDLKQQLAQALQEHWALME------------------EL 354
+ E LQ L++ Q + + +A +E A ++ E+
Sbjct: 786 IKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEV 845
Query: 355 NRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQ 402
KKD + A +++ ++ EK ++ E+ + + V E++L+
Sbjct: 846 EAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLE 893
Score = 36.2 bits (82), Expect = 0.069
Identities = 34/143 (23%), Positives = 68/143 (47%), Gaps = 12/143 (8%)
Query: 243 QRSLQMFKVTMSRILRLKIQMQE-----KHEAVMNVKKQTQKGNSKKVVQMEQELQDLQS 297
Q+ L++ K + KI+ ++ KH + + KQ + + ++ Q EQEL+
Sbjct: 1961 QQELEILKKEYDQEREEKIKQEQEDLELKHNSTL---KQLMREFNTQLAQKEQELEMTIK 2017
Query: 298 QLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRS 357
+ + Q+ E LE +E Q L+ +IA+ + DLK+ + + A EE+
Sbjct: 2018 ETINKA--QEVEAELLESHQEETNQLLK--KIAEKDDDLKRTAKRYEEILDAREEEMTAK 2073
Query: 358 KKDFEAIIQAKNKELEQTKEEKE 380
+D + ++ K+ +Q E++E
Sbjct: 2074 VRDLQTQLEELQKKYQQKLEQEE 2096
Score = 35.8 bits (81), Expect = 0.090
Identities = 41/154 (26%), Positives = 77/154 (50%), Gaps = 18/154 (11%)
Query: 263 MQEKHEAVMNVKKQTQKGNSKKVVQMEQ---ELQDLQSQLCAEQAQQQAR-----VEQLE 314
+QEK ++++ ++ +S V Q E E+++L S+ QA QQ E LE
Sbjct: 1842 LQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLE 1901
Query: 315 KTFQEEEQ-HLQGLEIAQG----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKN 369
+ +E+ + HL ++ DL+ +LA A +E L +E+ R +KD + +
Sbjct: 1902 ENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQ 1961
Query: 370 KELEQTKEE-----KEKMQAQKEEVLSHMNDVLE 398
+ELE K+E +EK++ ++E++ N L+
Sbjct: 1962 QELEILKKEYDQEREEKIKQEQEDLELKHNSTLK 1995
Score = 35.0 bits (79), Expect = 0.15
Identities = 39/225 (17%), Positives = 89/225 (39%), Gaps = 32/225 (14%)
Query: 202 NLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKI 261
+LD + +P + ++ EQ +RSL ++ S ++
Sbjct: 106 DLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQ 165
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEE 321
+Q + + + + Q+Q + +++ ++ +ELQ +Q ++ E+ + + +E++
Sbjct: 166 MLQREKKKLQGILSQSQDKSLRRIAELREELQ-------MDQQAKKHLQEEFDASLEEKD 218
Query: 322 QHL-----------QGLEIAQGEKDLKQQLAQALQEHWALMEELN------------RSK 358
Q++ Q L D+ + L Q + +E N S
Sbjct: 219 QYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSV 278
Query: 359 KDFEAIIQAKNKELEQTKEEKEKMQAQKEE--VLSHMNDVLENEL 401
K E + Q ++ K KE +Q+ KE+ +L+ + L+ +L
Sbjct: 279 KTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQL 323
Score = 34.3 bits (77), Expect = 0.26
Identities = 61/295 (20%), Positives = 120/295 (40%), Gaps = 57/295 (19%)
Query: 98 YSIHQGDYIQLGVPLENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFS 157
++ HQ +L + LE K YE D+ I KE ++
Sbjct: 1453 FTQHQNTVKELQIQLELKSKEAYE------------------KDEQINLLKEELDQQNKR 1494
Query: 158 LDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTG 217
D L G + S ++ K + + E +KSQ ++ LE T
Sbjct: 1495 FDCLKGEMEDDKSKMEKKESNLETE----LKSQ-------------TARIMELEDHITQK 1537
Query: 218 APIYPGFPKVTEVHHEQKASNSSASQRSLQMF-----------KVTMSRILRLKIQMQEK 266
+V + +++QK + LQ F K +IL L+ Q+
Sbjct: 1538 TIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSM 1597
Query: 267 HEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQG 326
+A + KK+ + + V E+EL+ L+ +L +E A A++ +L++ +++ ++
Sbjct: 1598 -KAELETKKKELEHVNLSVKSKEEELKALEDRLESESA---AKLAELKRKAEQKIAAIKK 1653
Query: 327 LEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA---IIQAKNKELEQTKEE 378
++Q E + ++Q + + H + ELN ++ E I++ K K +E ++ E
Sbjct: 1654 QLLSQME-EKEEQYKKGTESH---LSELNTKLQEREREVHILEEKLKSVESSQSE 1704
Score = 33.1 bits (74), Expect = 0.58
Identities = 37/148 (25%), Positives = 69/148 (46%), Gaps = 18/148 (12%)
Query: 259 LKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQ 318
LK Q + +A + K++ + + + VV+ ++ L++ Q+ R E L K +
Sbjct: 245 LKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETL-----QQRVKRQENLLKRCK 299
Query: 319 EEEQ-HLQGLEIAQGEKD-LKQQLAQALQE-------HWA----LMEELNRSKKDFEAII 365
E Q H + + EK+ L++QL + LQE H A L+ +L +K E +
Sbjct: 300 ETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLE 359
Query: 366 QAKNKELEQTKEEKEKMQAQKEEVLSHM 393
Q K + +TK + + KEE ++ +
Sbjct: 360 QDKGMVIAETKRQMHETLEMKEEEIAQL 387
Score = 30.8 bits (68), Expect = 2.9
Identities = 35/168 (20%), Positives = 72/168 (42%), Gaps = 32/168 (19%)
Query: 265 EKHEAVMNVKKQTQKGNSKKVVQMEQELQD----------------LQSQLCAEQAQQQA 308
EK + +KK+ + N V M++EL++ +Q Q ++++A
Sbjct: 1336 EKESCITQLKKELSE-NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEA 1394
Query: 309 RVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNR--------SKKD 360
+ L K + EE+ E+ +DL ++ +E + +E+++ KK
Sbjct: 1395 AISSLRKQYDEEK-----CELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA 1449
Query: 361 FEAIIQAKN--KELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
Q +N KEL+ E K K +K+E ++ + + L+ + + C
Sbjct: 1450 QSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDC 1497
Score = 30.4 bits (67), Expect = 3.8
Identities = 34/167 (20%), Positives = 71/167 (42%), Gaps = 25/167 (14%)
Query: 260 KIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQE 319
KI E+ + N + +K + Q + +++LQ QL + + + EQ+ +E
Sbjct: 1428 KISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEE 1487
Query: 320 EEQHLQGLEIAQG----------------EKDLKQQLAQ--ALQEHWAL----MEELNRS 357
+Q + + +G E +LK Q A+ L++H +E LN
Sbjct: 1488 LDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEV 1547
Query: 358 KKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMND---VLENEL 401
K++ ++KEL Q + +++ +K+ + + LEN++
Sbjct: 1548 LKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQV 1594
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 55.1 bits (131), Expect = 1e-07
Identities = 40/180 (22%), Positives = 89/180 (49%), Gaps = 14/180 (7%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQEL 292
EQ Q+ + ++ + + QM E+ E V ++Q QK +++ + E+++
Sbjct: 206 EQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQK-QEEQMRKQEEQM 264
Query: 293 QDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALME 352
++ + Q+ + Q++ ++Q E+T QEE+ Q ++ + E+ +++Q Q ++ + E
Sbjct: 265 REQEEQM---REQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMRE 321
Query: 353 ELNRSKKDFEAIIQAKN----------KELEQTKEEKEKMQAQKEEVLSHMNDVLENELQ 402
+ + K E + + K K+ EQ E++E+MQ Q+E+V + + E Q
Sbjct: 322 QEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQ 381
Score = 52.4 bits (124), Expect = 9e-07
Identities = 32/170 (18%), Positives = 88/170 (51%), Gaps = 8/170 (4%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQEL 292
EQ Q+ + + ++ + QM+E+ E ++ K+QT++ ++ + E+++
Sbjct: 241 EQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQ--EEQTGEQEEQM 298
Query: 293 QDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALME 352
++ + Q+ ++ Q + + EQ+ +E+E+ + E E+ K+Q+ + ++ W E
Sbjct: 299 REQEEQMREQEEQMREQEEQM----REQEEQMGKQEEQMWEQ--KEQMWEQKEQMWKQEE 352
Query: 353 ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQ 402
++ ++ + + K+ EQ ++++E+M+ Q+E++ + E + Q
Sbjct: 353 QMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQ 402
Score = 51.2 bits (121), Expect = 2e-06
Identities = 35/141 (24%), Positives = 80/141 (56%), Gaps = 8/141 (5%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEE 321
QM E+ E + ++Q QK +++ + E++++ + Q+ ++ Q Q + EQ++K QEE+
Sbjct: 200 QMGEQEEQMGEQEEQMQK-QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQK--QEEQ 256
Query: 322 QHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEK 381
Q ++ + E+ +++Q Q L++ E+ + ++ E Q + +E EQ +E++E+
Sbjct: 257 MRKQEEQMREQEEQMREQEEQMLKQK----EQTEQEEQTGEQEEQMREQE-EQMREQEEQ 311
Query: 382 MQAQKEEVLSHMNDVLENELQ 402
M+ Q+E++ + + E Q
Sbjct: 312 MREQEEQMREQEEQMGKQEEQ 332
Score = 43.9 bits (102), Expect = 3e-04
Identities = 29/131 (22%), Positives = 74/131 (56%), Gaps = 6/131 (4%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEE 321
QM+E+ E + ++Q ++ +++ + E+++ + Q+ ++ Q + EQ+ K QEE+
Sbjct: 297 QMREQEEQMREQEEQMRE-QEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWK--QEEQ 353
Query: 322 QHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK---ELEQTKEE 378
Q ++ + E+ +++Q Q ++ + ++ + +K E + + K + + EQ +E+
Sbjct: 354 MGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQ 413
Query: 379 KEKMQAQKEEV 389
+E+M QKE++
Sbjct: 414 EEQMGEQKEQM 424
Score = 43.9 bits (102), Expect = 3e-04
Identities = 31/128 (24%), Positives = 67/128 (52%), Gaps = 7/128 (5%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEE 321
QM+E+ E + ++Q K + Q EQ + + + Q+ ++ Q + EQ++K QEE+
Sbjct: 311 QMREQEEQMREQEEQMGKQEEQMWEQKEQ-MWEQKEQMWKQEEQMGEQEEQMQK--QEEQ 367
Query: 322 QHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEK 381
Q ++ + E+ +++Q Q ++ E++ K+ + ++ EQ E+KE+
Sbjct: 368 VRKQEEQMRKQEEQMRKQEEQMRKQE----EQMGEQKEQMGEQKEQMREQEEQMGEQKEQ 423
Query: 382 MQAQKEEV 389
M+ Q+E +
Sbjct: 424 MRKQEEHM 431
Score = 43.5 bits (101), Expect = 4e-04
Identities = 31/148 (20%), Positives = 78/148 (52%), Gaps = 8/148 (5%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQL-----EKT 316
Q++E+ V + Q ++ + + + E ++ + + Q+ ++ Q Q + EQ+ +
Sbjct: 172 QVREQEGQVREQEGQVREQEGQ-MGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMR 230
Query: 317 FQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAK--NKELEQ 374
QEE+ Q ++ + E+ +++Q Q ++ + E+ + ++ E +++ K ++ EQ
Sbjct: 231 KQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQ 290
Query: 375 TKEEKEKMQAQKEEVLSHMNDVLENELQ 402
T E++E+M+ Q+E++ + E E Q
Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQEEQ 318
Score = 40.8 bits (94), Expect = 0.003
Identities = 30/148 (20%), Positives = 76/148 (51%), Gaps = 7/148 (4%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQ--DLQSQLCAEQAQ---QQARVEQ 312
+++ Q + E V++Q + ++ EQE Q + + Q+ ++ Q Q+ ++ +
Sbjct: 144 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGE 203
Query: 313 LEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKEL 372
E+ E+E+ +Q E GE++ +Q+ + ++ E++ + ++ + + K+
Sbjct: 204 QEEQMGEQEEQMQKQEEQMGEQE--EQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQE 261
Query: 373 EQTKEEKEKMQAQKEEVLSHMNDVLENE 400
EQ +E++E+M+ Q+E++L + E
Sbjct: 262 EQMREQEEQMREQEEQMLKQKEQTEQEE 289
Score = 38.5 bits (88), Expect = 0.014
Identities = 28/146 (19%), Positives = 74/146 (50%), Gaps = 6/146 (4%)
Query: 262 QMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQ---QQARVEQLEKTFQ 318
Q++E+ V + Q ++ + V + E ++++ + Q+ ++ Q Q+ +V + E
Sbjct: 137 QVREQEGQVREQEGQVREQEGQ-VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMG 195
Query: 319 EEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEE 378
E+E + E GE++ +Q+ + ++ E++ + ++ + K+ EQ +++
Sbjct: 196 EQEGQMGEQEEQMGEQE--EQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQ 253
Query: 379 KEKMQAQKEEVLSHMNDVLENELQCI 404
+E+M+ Q+E++ + E E Q +
Sbjct: 254 EEQMRKQEEQMREQEEQMREQEEQML 279
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2575 QLEQQRR----QQEELLAEENQRLREQLQLL 2601
Score = 44.3 bits (103), Expect = 3e-04
Identities = 44/168 (26%), Positives = 81/168 (48%), Gaps = 20/168 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1312 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1370
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCI 404
A IQAK ++ E + EE+ ++ + E E ELQ +
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2218 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2278 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Score = 39.3 bits (90), Expect = 0.008
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1524 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1572
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1630
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1631 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1672
Score = 39.3 bits (90), Expect = 0.008
Identities = 31/129 (24%), Positives = 58/129 (44%), Gaps = 8/129 (6%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2091 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2146
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEK---- 379
+ + Q KQ +++H E+ R K E + +LE+T +K
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 380 EKMQAQKEE 388
E++Q K E
Sbjct: 2207 EELQRLKAE 2215
Score = 38.9 bits (89), Expect = 0.011
Identities = 37/173 (21%), Positives = 76/173 (43%), Gaps = 27/173 (15%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1709 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1748
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLE 398
+ L EL + + + E ++ +K + E+++ EK + + E ++ E
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Score = 38.9 bits (89), Expect = 0.011
Identities = 50/208 (24%), Positives = 90/208 (43%), Gaps = 48/208 (23%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2413
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2414 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2463
Query: 384 AQ-------KEEVLSHMNDVLENELQCI 404
+ EE+ + + L E Q +
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQAL 2491
Score = 38.1 bits (87), Expect = 0.018
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2116
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2172
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Score = 37.7 bits (86), Expect = 0.024
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2511
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2512 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2569 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2620
Score = 37.0 bits (84), Expect = 0.040
Identities = 41/182 (22%), Positives = 88/182 (48%), Gaps = 32/182 (17%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1769
Query: 407 SE 408
S+
Sbjct: 1770 SK 1771
Score = 36.6 bits (83), Expect = 0.053
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2215
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2216 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2267 QEEAEKMKQVAEE 2279
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2461 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2520
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2521 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2579 QLEQQRR----QQEELLAEENQRLREQLQLL 2605
Score = 44.3 bits (103), Expect = 3e-04
Identities = 44/168 (26%), Positives = 81/168 (48%), Gaps = 20/168 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1316 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1374
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1375 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1434
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCI 404
A IQAK ++ E + EE+ ++ + E E ELQ +
Sbjct: 1435 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1482
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2222 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2281
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2282 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2339
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2340 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2396
Score = 39.3 bits (90), Expect = 0.008
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1528 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1576
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1577 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1634
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1635 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1676
Score = 39.3 bits (90), Expect = 0.008
Identities = 31/129 (24%), Positives = 58/129 (44%), Gaps = 8/129 (6%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2095 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2150
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEK---- 379
+ + Q KQ +++H E+ R K E + +LE+T +K
Sbjct: 2151 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2210
Query: 380 EKMQAQKEE 388
E++Q K E
Sbjct: 2211 EELQRLKAE 2219
Score = 38.9 bits (89), Expect = 0.011
Identities = 37/173 (21%), Positives = 76/173 (43%), Gaps = 27/173 (15%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1712
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1713 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1752
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLE 398
+ L EL + + + E ++ +K + E+++ EK + + E ++ E
Sbjct: 1753 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805
Score = 38.9 bits (89), Expect = 0.011
Identities = 50/208 (24%), Positives = 90/208 (43%), Gaps = 48/208 (23%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2358
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2359 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2417
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2418 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2467
Query: 384 AQ-------KEEVLSHMNDVLENELQCI 404
+ EE+ + + L E Q +
Sbjct: 2468 QEAKLLQLKSEEMQTVQQEQLLQETQAL 2495
Score = 38.1 bits (87), Expect = 0.018
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 2002 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2061
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2062 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2120
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2176
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2177 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2214
Score = 37.7 bits (86), Expect = 0.024
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2456 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2515
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2516 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2572
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2573 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2624
Score = 37.0 bits (84), Expect = 0.040
Identities = 41/182 (22%), Positives = 88/182 (48%), Gaps = 32/182 (17%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1595 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1654
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1655 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1714
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1715 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1773
Query: 407 SE 408
S+
Sbjct: 1774 SK 1775
Score = 36.6 bits (83), Expect = 0.053
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2161 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2219
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2220 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2270
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2271 QEEAEKMKQVAEE 2283
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2457 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2516
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2575 QLEQQRR----QQEELLAEENQRLREQLQLL 2601
Score = 44.3 bits (103), Expect = 3e-04
Identities = 44/168 (26%), Positives = 81/168 (48%), Gaps = 20/168 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1312 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1370
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCI 404
A IQAK ++ E + EE+ ++ + E E ELQ +
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1478
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2218 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2277
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2278 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2392
Score = 39.3 bits (90), Expect = 0.008
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1524 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1572
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1573 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1630
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1631 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1672
Score = 39.3 bits (90), Expect = 0.008
Identities = 31/129 (24%), Positives = 58/129 (44%), Gaps = 8/129 (6%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2091 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2146
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEK---- 379
+ + Q KQ +++H E+ R K E + +LE+T +K
Sbjct: 2147 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2206
Query: 380 EKMQAQKEE 388
E++Q K E
Sbjct: 2207 EELQRLKAE 2215
Score = 38.9 bits (89), Expect = 0.011
Identities = 37/173 (21%), Positives = 76/173 (43%), Gaps = 27/173 (15%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1709 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1748
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLE 398
+ L EL + + + E ++ +K + E+++ EK + + E ++ E
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Score = 38.9 bits (89), Expect = 0.011
Identities = 50/208 (24%), Positives = 90/208 (43%), Gaps = 48/208 (23%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2413
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2414 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2463
Query: 384 AQ-------KEEVLSHMNDVLENELQCI 404
+ EE+ + + L E Q +
Sbjct: 2464 QEAKLLQLKSEEMQTVQQEQLLQETQAL 2491
Score = 38.1 bits (87), Expect = 0.018
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 1998 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2057
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2058 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2116
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2172
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2173 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2210
Score = 37.7 bits (86), Expect = 0.024
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2452 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2511
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2512 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2569 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2620
Score = 37.0 bits (84), Expect = 0.040
Identities = 41/182 (22%), Positives = 88/182 (48%), Gaps = 32/182 (17%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1650
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1651 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1711 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1769
Query: 407 SE 408
S+
Sbjct: 1770 SK 1771
Score = 36.6 bits (83), Expect = 0.053
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2157 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2215
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2216 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2266
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2267 QEEAEKMKQVAEE 2279
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2425 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2484
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2485 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2543 QLEQQRR----QQEELLAEENQRLREQLQLL 2569
Score = 44.3 bits (103), Expect = 3e-04
Identities = 44/168 (26%), Positives = 81/168 (48%), Gaps = 20/168 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1280 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1338
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1339 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1398
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCI 404
A IQAK ++ E + EE+ ++ + E E ELQ +
Sbjct: 1399 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1446
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2186 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2245
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2246 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2303
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2304 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2360
Score = 39.3 bits (90), Expect = 0.008
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1492 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1540
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1541 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1598
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1599 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1640
Score = 39.3 bits (90), Expect = 0.008
Identities = 31/129 (24%), Positives = 58/129 (44%), Gaps = 8/129 (6%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2059 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2114
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEK---- 379
+ + Q KQ +++H E+ R K E + +LE+T +K
Sbjct: 2115 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2174
Query: 380 EKMQAQKEE 388
E++Q K E
Sbjct: 2175 EELQRLKAE 2183
Score = 38.9 bits (89), Expect = 0.011
Identities = 37/173 (21%), Positives = 76/173 (43%), Gaps = 27/173 (15%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1676
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1677 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1716
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLE 398
+ L EL + + + E ++ +K + E+++ EK + + E ++ E
Sbjct: 1717 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769
Score = 38.9 bits (89), Expect = 0.011
Identities = 50/208 (24%), Positives = 90/208 (43%), Gaps = 48/208 (23%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2322
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2323 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2381
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2382 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2431
Query: 384 AQ-------KEEVLSHMNDVLENELQCI 404
+ EE+ + + L E Q +
Sbjct: 2432 QEAKLLQLKSEEMQTVQQEQLLQETQAL 2459
Score = 38.1 bits (87), Expect = 0.018
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 1966 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2025
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2026 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2084
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2140
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2141 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2178
Score = 37.7 bits (86), Expect = 0.024
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2420 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2479
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2480 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2536
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2537 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2588
Score = 37.0 bits (84), Expect = 0.040
Identities = 41/182 (22%), Positives = 88/182 (48%), Gaps = 32/182 (17%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1559 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1618
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1619 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1678
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1679 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1737
Query: 407 SE 408
S+
Sbjct: 1738 SK 1739
Score = 36.6 bits (83), Expect = 0.053
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2125 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2183
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2184 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2234
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2235 QEEAEKMKQVAEE 2247
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2594 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2653
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2654 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2712 QLEQQRR----QQEELLAEENQRLREQLQLL 2738
Score = 44.3 bits (103), Expect = 3e-04
Identities = 44/168 (26%), Positives = 81/168 (48%), Gaps = 20/168 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1449 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1507
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1508 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1567
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCI 404
A IQAK ++ E + EE+ ++ + E E ELQ +
Sbjct: 1568 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1615
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2355 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2414
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2415 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2472
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2473 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2529
Score = 39.3 bits (90), Expect = 0.008
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1661 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1709
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1710 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1767
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1768 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1809
Score = 39.3 bits (90), Expect = 0.008
Identities = 31/129 (24%), Positives = 58/129 (44%), Gaps = 8/129 (6%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2228 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2283
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEK---- 379
+ + Q KQ +++H E+ R K E + +LE+T +K
Sbjct: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343
Query: 380 EKMQAQKEE 388
E++Q K E
Sbjct: 2344 EELQRLKAE 2352
Score = 38.9 bits (89), Expect = 0.011
Identities = 37/173 (21%), Positives = 76/173 (43%), Gaps = 27/173 (15%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1845
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1846 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1885
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLE 398
+ L EL + + + E ++ +K + E+++ EK + + E ++ E
Sbjct: 1886 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938
Score = 38.9 bits (89), Expect = 0.011
Identities = 50/208 (24%), Positives = 90/208 (43%), Gaps = 48/208 (23%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2491
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2492 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2550
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2551 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2600
Query: 384 AQ-------KEEVLSHMNDVLENELQCI 404
+ EE+ + + L E Q +
Sbjct: 2601 QEAKLLQLKSEEMQTVQQEQLLQETQAL 2628
Score = 38.1 bits (87), Expect = 0.018
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2194
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2195 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2253
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2309
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2310 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2347
Score = 37.7 bits (86), Expect = 0.024
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2589 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2648
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2649 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2705
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2706 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2757
Score = 37.0 bits (84), Expect = 0.040
Identities = 41/182 (22%), Positives = 88/182 (48%), Gaps = 32/182 (17%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1728 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1787
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1788 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1847
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1848 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1906
Query: 407 SE 408
S+
Sbjct: 1907 SK 1908
Score = 36.6 bits (83), Expect = 0.053
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2294 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2352
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2353 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2403
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2404 QEEAEKMKQVAEE 2416
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2435 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2494
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2495 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2553 QLEQQRR----QQEELLAEENQRLREQLQLL 2579
Score = 44.3 bits (103), Expect = 3e-04
Identities = 44/168 (26%), Positives = 81/168 (48%), Gaps = 20/168 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1290 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1348
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1349 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1408
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCI 404
A IQAK ++ E + EE+ ++ + E E ELQ +
Sbjct: 1409 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1456
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2196 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2255
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2256 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2313
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2314 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2370
Score = 39.3 bits (90), Expect = 0.008
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1502 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1550
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1551 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1608
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1609 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1650
Score = 39.3 bits (90), Expect = 0.008
Identities = 31/129 (24%), Positives = 58/129 (44%), Gaps = 8/129 (6%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2069 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2124
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEK---- 379
+ + Q KQ +++H E+ R K E + +LE+T +K
Sbjct: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
Query: 380 EKMQAQKEE 388
E++Q K E
Sbjct: 2185 EELQRLKAE 2193
Score = 38.9 bits (89), Expect = 0.011
Identities = 37/173 (21%), Positives = 76/173 (43%), Gaps = 27/173 (15%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1686
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1687 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1726
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLE 398
+ L EL + + + E ++ +K + E+++ EK + + E ++ E
Sbjct: 1727 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1779
Score = 38.9 bits (89), Expect = 0.011
Identities = 50/208 (24%), Positives = 90/208 (43%), Gaps = 48/208 (23%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2332
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2333 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2391
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2392 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2441
Query: 384 AQ-------KEEVLSHMNDVLENELQCI 404
+ EE+ + + L E Q +
Sbjct: 2442 QEAKLLQLKSEEMQTVQQEQLLQETQAL 2469
Score = 38.1 bits (87), Expect = 0.018
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2035
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2036 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2094
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2150
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2151 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2188
Score = 37.7 bits (86), Expect = 0.024
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2430 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2489
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2490 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2546
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2547 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2598
Score = 37.0 bits (84), Expect = 0.040
Identities = 41/182 (22%), Positives = 88/182 (48%), Gaps = 32/182 (17%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1569 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1628
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1629 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1688
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1689 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1747
Query: 407 SE 408
S+
Sbjct: 1748 SK 1749
Score = 36.6 bits (83), Expect = 0.053
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2135 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2193
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2194 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2244
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2245 QEEAEKMKQVAEE 2257
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2443 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2502
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2503 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2560
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2561 QLEQQRR----QQEELLAEENQRLREQLQLL 2587
Score = 44.3 bits (103), Expect = 3e-04
Identities = 44/168 (26%), Positives = 81/168 (48%), Gaps = 20/168 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1298 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1356
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1357 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1416
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCI 404
A IQAK ++ E + EE+ ++ + E E ELQ +
Sbjct: 1417 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1464
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2204 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2263
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2264 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2321
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2322 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2378
Score = 39.3 bits (90), Expect = 0.008
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1510 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1558
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1559 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1616
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1617 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1658
Score = 39.3 bits (90), Expect = 0.008
Identities = 31/129 (24%), Positives = 58/129 (44%), Gaps = 8/129 (6%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2077 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2132
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEK---- 379
+ + Q KQ +++H E+ R K E + +LE+T +K
Sbjct: 2133 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2192
Query: 380 EKMQAQKEE 388
E++Q K E
Sbjct: 2193 EELQRLKAE 2201
Score = 38.9 bits (89), Expect = 0.011
Identities = 37/173 (21%), Positives = 76/173 (43%), Gaps = 27/173 (15%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1694
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1695 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1734
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLE 398
+ L EL + + + E ++ +K + E+++ EK + + E ++ E
Sbjct: 1735 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1787
Score = 38.9 bits (89), Expect = 0.011
Identities = 50/208 (24%), Positives = 90/208 (43%), Gaps = 48/208 (23%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2340
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2341 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2399
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2400 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2449
Query: 384 AQ-------KEEVLSHMNDVLENELQCI 404
+ EE+ + + L E Q +
Sbjct: 2450 QEAKLLQLKSEEMQTVQQEQLLQETQAL 2477
Score = 38.1 bits (87), Expect = 0.018
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 1984 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2043
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2044 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2102
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2103 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2158
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2159 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2196
Score = 37.7 bits (86), Expect = 0.024
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2438 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2497
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2498 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2554
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2555 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2606
Score = 37.0 bits (84), Expect = 0.040
Identities = 41/182 (22%), Positives = 88/182 (48%), Gaps = 32/182 (17%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1577 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1636
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1637 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1696
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1697 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1755
Query: 407 SE 408
S+
Sbjct: 1756 SK 1757
Score = 36.6 bits (83), Expect = 0.053
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2143 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2201
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2202 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2252
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2253 QEEAEKMKQVAEE 2265
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 55.1 bits (131), Expect = 1e-07
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 16/151 (10%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQD---LQSQLCAEQ---AQQQARVEQ----L 313
+EK + K K + VQ EQ LQ+ LQ +E+ Q++ +EQ L
Sbjct: 2484 REKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKL 2543
Query: 314 EKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELE 373
E+ FQ+E Q L Q + +QQ+ Q Q A MEE R + + E ++ K +EL+
Sbjct: 2544 EQLFQDEVAKAQQLREEQQRQ--QQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601
Query: 374 QTKEEKEKMQAQKEEVLSHMNDVLENELQCI 404
Q ++++ Q+EE+L+ N L +LQ +
Sbjct: 2602 QLEQQRR----QQEELLAEENQRLREQLQLL 2628
Score = 44.3 bits (103), Expect = 3e-04
Identities = 44/168 (26%), Positives = 81/168 (48%), Gaps = 20/168 (11%)
Query: 256 ILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQ-LE 314
+++ + ++ + + + Q K S+ + +ME+E + L Q AE+ ++ A VE LE
Sbjct: 1339 VIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEE-ERLAEQQRAEERERLAEVEAALE 1397
Query: 315 KTFQEEEQHLQGLEIAQGE-KDLKQQLAQ-----------ALQEHWALMEELNRSKKDFE 362
K Q E H Q A+ E K+L+Q++ + A Q+ ++ EEL + ++ E
Sbjct: 1398 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1457
Query: 363 AIIQAKNKELEQTK------EEKEKMQAQKEEVLSHMNDVLENELQCI 404
A IQAK ++ E + EE+ ++ + E E ELQ +
Sbjct: 1458 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1505
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/177 (23%), Positives = 84/177 (47%), Gaps = 23/177 (12%)
Query: 234 QKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEA-VMNVKKQTQKGNSKKVVQMEQEL 292
+ A S + L +V M + +LK +++ ++ A ++ K TQ+ ++ +M+Q
Sbjct: 2245 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2304
Query: 293 QDLQSQLCAEQAQQQARVEQL------------EKTFQEEEQHLQGL-------EIAQGE 333
++ A AQ+ AR+ QL EK +E+ Q +Q E+ Q +
Sbjct: 2305 EEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2362
Query: 334 KDLKQQLAQALQEHWALM-EELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K+L Q+ A+ LQE M ++L + F+ ++A+ + + E E+++ + E+
Sbjct: 2363 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2419
Score = 39.3 bits (90), Expect = 0.008
Identities = 40/164 (24%), Positives = 79/164 (48%), Gaps = 26/164 (15%)
Query: 235 KASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKV-VQMEQELQ 293
+A + QR+LQ + L++Q +E + +Q + +++V V +E +
Sbjct: 1551 EAEAAREKQRALQALE-------ELRLQAEEAERRL----RQAEVERARQVQVALETAQR 1599
Query: 294 DLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ-------- 345
+++L +++A + QLE++ QEE H+ ++ + + QQ A+A +
Sbjct: 1600 SAEAELQSKRASFAEKTAQLERSLQEE--HVAVAQLREEAERRAQQQAEAERAREEAERE 1657
Query: 346 -EHWAL-MEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKE 387
E W L E R + E + A+ K L Q + EK+K +A++E
Sbjct: 1658 LERWQLKANEALRLRLQAEEV--AQQKSLAQAEAEKQKEEAERE 1699
Score = 39.3 bits (90), Expect = 0.008
Identities = 31/129 (24%), Positives = 58/129 (44%), Gaps = 8/129 (6%)
Query: 264 QEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQH 323
+E EA V+ + + S++ V+ + L+ + +AQ QA E+L K + E++
Sbjct: 2118 EEAEEA--RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEA 2173
Query: 324 LQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEK---- 379
+ + Q KQ +++H E+ R K E + +LE+T +K
Sbjct: 2174 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2233
Query: 380 EKMQAQKEE 388
E++Q K E
Sbjct: 2234 EELQRLKAE 2242
Score = 38.9 bits (89), Expect = 0.011
Identities = 37/173 (21%), Positives = 76/173 (43%), Gaps = 27/173 (15%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLK-------IQMQEKHEAVMNVKKQTQKGNSKKV 285
E+ A S +Q + K R R + ++ +E E + ++Q +G +++
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1735
Query: 286 VQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQ 345
+ EQEL L+++ EQ +QQ ++ +EE LQ ++ A A Q
Sbjct: 1736 LAAEQELIRLRAE--TEQGEQQRQL------LEEELARLQ------------REAAAATQ 1775
Query: 346 EHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLE 398
+ L EL + + + E ++ +K + E+++ EK + + E ++ E
Sbjct: 1776 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828
Score = 38.9 bits (89), Expect = 0.011
Identities = 50/208 (24%), Positives = 90/208 (43%), Gaps = 48/208 (23%)
Query: 234 QKASNSSASQRSL--QMFKVTMSRI---LRLKIQ---MQEKHEAVMNVKKQTQKGNSKKV 285
Q A A QR+L +M K M + RLK + +Q++ E ++ Q+ +
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2381
Query: 286 VQMEQELQDLQSQLCAEQAQQ--------------------QARVEQLEKTFQEEEQHLQ 325
Q+ +E Q Q L AE+ +Q QAR E+ + F+++ + +
Sbjct: 2382 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEI- 2440
Query: 326 GLEIAQGEKDLKQQLAQALQEHWALME--ELNRSKKDFEAIIQAKNKELEQTKEEKEKMQ 383
GEK + +LA QE L++ E+ R + D +A + + + + + EKEK+Q
Sbjct: 2441 ------GEKLHRTELAT--QEKVTLVQTLEIQRQQSDHDA--ERLREAIAELEREKEKLQ 2490
Query: 384 AQ-------KEEVLSHMNDVLENELQCI 404
+ EE+ + + L E Q +
Sbjct: 2491 QEAKLLQLKSEEMQTVQQEQLLQETQAL 2518
Score = 38.1 bits (87), Expect = 0.018
Identities = 51/218 (23%), Positives = 86/218 (39%), Gaps = 53/218 (24%)
Query: 233 EQKASNSSASQRSLQMFKVTMSRILRLKI--------QMQEKHEAVMNVKKQTQKGNSKK 284
E+ A A+ ++ K + RL+ Q+Q EA + +K ++
Sbjct: 2025 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFA 2084
Query: 285 VVQMEQELQDLQSQ----------------LCAEQAQQQAR-------------VEQLEK 315
V Q EQELQ Q AE+A+ +AR VE+ E+
Sbjct: 2085 VQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVEEAER 2143
Query: 316 TFQEEEQHLQGLEIAQG-----EKDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNK 370
Q E+ Q AQ K+ +Q+ A+ Q A + R K+ +A ++ K
Sbjct: 2144 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKK 2199
Query: 371 ELEQTKEEKEKMQAQ------KEEVLSHMNDVLENELQ 402
EQT +K +++ + + E H ++L+ ELQ
Sbjct: 2200 FAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQ 2237
Score = 37.7 bits (86), Expect = 0.024
Identities = 32/178 (17%), Positives = 87/178 (48%), Gaps = 12/178 (6%)
Query: 227 VTEVHHEQKASNSSASQ---RSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
+ E+ E++ A +S +M V ++L+ +Q+ + + Q ++ +
Sbjct: 2479 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2538
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQA 343
+ ++EQ QD ++ + +QQ + +Q+E QE ++ + +E A+ + ++ +
Sbjct: 2539 EKAKLEQLFQDEVAKAQQLREEQQRQQQQME---QERQRLVASMEEARRRQHEAEEGVRR 2595
Query: 344 LQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENEL 401
QE +++L + ++ E ++ +N+ L +E+ + ++ Q L+H +V +++
Sbjct: 2596 KQEE---LQQLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2647
Score = 37.0 bits (84), Expect = 0.040
Identities = 41/182 (22%), Positives = 88/182 (48%), Gaps = 32/182 (17%)
Query: 258 RLKIQMQEKHEAVMNVKKQTQKGNSKKVV------QMEQELQD--------LQSQLCAEQ 303
+L+ +QE+H AV ++++ ++ ++ + E+EL+ L+ +L AE+
Sbjct: 1618 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1677
Query: 304 AQQQARVEQLEKTFQE-------------EEQHLQGLEIAQGEKDLKQQLAQ-ALQEHWA 349
QQ + Q E Q+ EEQ ++ E+A+ E + ++QLA+ Q+ A
Sbjct: 1678 VAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1737
Query: 350 LMEELNRSKKDFEAIIQAK---NKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIIC 406
+EL R + + E Q + +EL + + E +++E+ + + V E++ ++
Sbjct: 1738 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-RAEMEVLLA 1796
Query: 407 SE 408
S+
Sbjct: 1797 SK 1798
Score = 36.6 bits (83), Expect = 0.053
Identities = 34/133 (25%), Positives = 62/133 (46%), Gaps = 15/133 (11%)
Query: 261 IQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE 320
++ ++ +A M K+ + ++ Q+EQEL L+ QL Q+ E+L++ E
Sbjct: 2184 LRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE- 2242
Query: 321 EQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEA-----IIQAKNKELEQT 375
E A+ ++++L + MEEL++ K EA I++ K+
Sbjct: 2243 -----ATEAARQRSQVEEELFSVRVQ----MEELSKLKARIEAENRALILRDKDNTQRFL 2293
Query: 376 KEEKEKMQAQKEE 388
+EE EKM+ EE
Sbjct: 2294 QEEAEKMKQVAEE 2306
>gi|239048862 checkpoint with forkhead and ring finger domains
isoform 2 [Homo sapiens]
Length = 663
Score = 54.7 bits (130), Expect = 2e-07
Identities = 94/425 (22%), Positives = 151/425 (35%), Gaps = 106/425 (24%)
Query: 37 EVTVGRGFGVTYQLVSKICPLMISRNHC-VLKQNPEGQWTIMDNKSLNGVWLNRARLEPL 95
E T+GR G S ++S +HC ++ GQ T+ D S +G +N+ ++
Sbjct: 37 EWTIGRRRGCDLSFPSN---KLVSGDHCRIVVDEKSGQVTLEDT-STSGTVINKLKVVKK 92
Query: 96 RVYSIHQGDYIQLGVPLENKE-NAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKE-LRTK 153
+ + GD I L E N Y YE E + E NKE +
Sbjct: 93 QTCPLQTGDVIYLVYRKNEPEHNVAYLYESLSEK--------QGMTQESFEANKENVFHG 144
Query: 154 RKFSLDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKGEVASTPSDNLDPKLTALEPS 213
K + AG GA+ S +V E QP ST + +L P +A S
Sbjct: 145 TKDTSGAGAGRGADPRVPPSSPATQVCFEEPQP----------STSTSDLFPTASA---S 191
Query: 214 KTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNV 273
T +P +++S+ + +
Sbjct: 192 STEPSPA-----------GRERSSSCGSGGGGI--------------------------- 213
Query: 274 KKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGE 333
+ KG+ V E + S A ++ A LE QE+ + ++ G+
Sbjct: 214 ---SPKGSGPSVASDE-----VSSFASALPDRKTASFSSLEPQDQEDLEPVKKKMRGDGD 265
Query: 334 KDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHM 393
DL QL + A+ + QT E + A K
Sbjct: 266 LDLNGQL------------------------LVAQPRRNAQTVHEDVRAAAGKP------ 295
Query: 394 NDVLENELQCIICSEYFIEAVTLN-CAHSFCSYCINEWMKRKIECPICRKDIKSKTYSLV 452
D +E L CIIC + + V+L C H+FC+ C + WM+R CP CR ++ + +
Sbjct: 296 -DKMEETLTCIICQDLLHDCVSLQPCMHTFCAACYSGWMERSSLCPTCRCPVERICKNHI 354
Query: 453 LDNCI 457
L+N +
Sbjct: 355 LNNLV 359
>gi|239048792 checkpoint with forkhead and ring finger domains
isoform 1 [Homo sapiens]
Length = 664
Score = 54.7 bits (130), Expect = 2e-07
Identities = 94/425 (22%), Positives = 151/425 (35%), Gaps = 106/425 (24%)
Query: 37 EVTVGRGFGVTYQLVSKICPLMISRNHC-VLKQNPEGQWTIMDNKSLNGVWLNRARLEPL 95
E T+GR G S ++S +HC ++ GQ T+ D S +G +N+ ++
Sbjct: 37 EWTIGRRRGCDLSFPSN---KLVSGDHCRIVVDEKSGQVTLEDT-STSGTVINKLKVVKK 92
Query: 96 RVYSIHQGDYIQLGVPLENKE-NAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKE-LRTK 153
+ + GD I L E N Y YE E + E NKE +
Sbjct: 93 QTCPLQTGDVIYLVYRKNEPEHNVAYLYESLSEK--------QGMTQESFEANKENVFHG 144
Query: 154 RKFSLDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKGEVASTPSDNLDPKLTALEPS 213
K + AG GA+ S +V E QP ST + +L P +A S
Sbjct: 145 TKDTSGAGAGRGADPRVPPSSPATQVCFEEPQP----------STSTSDLFPTASA---S 191
Query: 214 KTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNV 273
T +P +++S+ + +
Sbjct: 192 STEPSPA-----------GRERSSSCGSGGGGI--------------------------- 213
Query: 274 KKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQGLEIAQGE 333
+ KG+ V E + S A ++ A LE QE+ + ++ G+
Sbjct: 214 ---SPKGSGPSVASDE-----VSSFASALPDRKTASFSSLEPQDQEDLEPVKKKMRGDGD 265
Query: 334 KDLKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHM 393
DL QL + A+ + QT E + A K
Sbjct: 266 LDLNGQL------------------------LVAQPRRNAQTVHEDVRAAAGKP------ 295
Query: 394 NDVLENELQCIICSEYFIEAVTLN-CAHSFCSYCINEWMKRKIECPICRKDIKSKTYSLV 452
D +E L CIIC + + V+L C H+FC+ C + WM+R CP CR ++ + +
Sbjct: 296 -DKMEETLTCIICQDLLHDCVSLQPCMHTFCAACYSGWMERSSLCPTCRCPVERICKNHI 354
Query: 453 LDNCI 457
L+N +
Sbjct: 355 LNNLV 359
>gi|34878777 ring finger protein 20 [Homo sapiens]
Length = 975
Score = 54.7 bits (130), Expect = 2e-07
Identities = 55/229 (24%), Positives = 100/229 (43%), Gaps = 40/229 (17%)
Query: 247 QMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQM-EQELQDLQSQLCAEQAQ 305
Q F+ + +RL Q++EK +A N K +++ S ++ ++ ++E ++L Q+ + Q
Sbjct: 737 QAFEDMQEQNIRLMQQLREKDDA--NFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQ 794
Query: 306 QQARVEQLEKTFQEEEQHLQGLEIAQGEKDLKQQLAQALQEHWALMEELNRSKKDFEAII 365
A+++ + K EE++HL I GEK+L + QAL+ + E + D +A +
Sbjct: 795 VDAQLQVVRKL--EEKEHLLQSNIGTGEKELGLR-TQALEMNKRKAMEAAQLADDLKAQL 851
Query: 366 QAKNKELEQTKEEKEKMQAQKE----------EVLSHMNDVLEN---------------- 399
+ K+L ++E + KE E +S + LE
Sbjct: 852 ELAQKKLHDFQDEIVENSVTKEKDMFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILME 911
Query: 400 -------ELQCIICSEYFIEAVTLNCAHSFCSYCI-NEWMKRKIECPIC 440
L C C+ +AV C H FC C+ + R+ +CP C
Sbjct: 912 EIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKC 960
Score = 33.5 bits (75), Expect = 0.44
Identities = 47/255 (18%), Positives = 100/255 (39%), Gaps = 51/255 (20%)
Query: 222 PGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMN--------- 272
P F + + S Q ++ + +S+I+ + ++QEK E +
Sbjct: 154 PAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVELLSRKLNSGDNLI 213
Query: 273 VKKQTQKGNS------KKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEEEQHLQG 326
V++ Q+ NS ++ ++ LQ+ + E ++ Q++VE E E +
Sbjct: 214 VEEAVQELNSFLAQENMRLQELTDLLQEKHRTMSQEFSKLQSKVETAESRVSVLESMIDD 273
Query: 327 LE-----IAQGEKDLKQQLAQALQE----------------------HWALMEELNRSKK 359
L+ I + E+ L + LA+ L+ + EE+N +
Sbjct: 274 LQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELE 333
Query: 360 DFEAIIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEAVTLNCA 419
+ + + Q + ELE+ +++ E++ Q E++ + +E ++ E C
Sbjct: 334 ENKELAQNRLCELEKLRQDFEEVTTQNEKLKVELRSAVEQVVK---------ETPEYRCM 384
Query: 420 HSFCSYCINEWMKRK 434
S S NE ++ K
Sbjct: 385 QSQFSVLYNESLQLK 399
Score = 30.8 bits (68), Expect = 2.9
Identities = 62/294 (21%), Positives = 119/294 (40%), Gaps = 41/294 (13%)
Query: 104 DYIQLGVPLENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAG 163
+Y L + E A + + + L N Q+ K + LR KRK
Sbjct: 451 EYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQL--KGEVLRYKRKLR------ 502
Query: 164 PGAEGPSNLKSKINKVSCESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPG 223
+S +NK SG + + S DPK EP A + P
Sbjct: 503 -------EAQSDLNKTRLRSGSAL--------LQSQSSTEDPKD---EP-----AELKPD 539
Query: 224 FPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSK 283
++ KAS A++ + + R R K + +E+ E +++ +K K
Sbjct: 540 SEDLSSQSSASKASQEDANEIKSKRDEEERERERREKERERER-EREKEKEREREKQKLK 598
Query: 284 KVVQMEQELQDLQSQLCAEQAQQQARV-EQLE---KTFQEEEQHLQGL----EIAQGEKD 335
+ + +D + + +++A + +QL+ K QE ++ ++ L A E+
Sbjct: 599 ESEKERDSAKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQR 658
Query: 336 LKQQLAQALQEHWALMEELNRSKKDFEAIIQAKNKELEQTKEEKEKMQAQKEEV 389
K QL A ++ A +E+L + KD E + +NK++ ++ K++A +E++
Sbjct: 659 DKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMAD-EDALRKIRAVEEQI 711
>gi|239048909 checkpoint with forkhead and ring finger domains
isoform 5 [Homo sapiens]
Length = 572
Score = 53.9 bits (128), Expect = 3e-07
Identities = 29/95 (30%), Positives = 48/95 (50%), Gaps = 8/95 (8%)
Query: 364 IIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEAVTLN-CAHSF 422
++ A+ + QT E + A K D +E L CIIC + + V+L C H+F
Sbjct: 180 LLVAQPRRNAQTVHEDVRAAAGKP-------DKMEETLTCIICQDLLHDCVSLQPCMHTF 232
Query: 423 CSYCINEWMKRKIECPICRKDIKSKTYSLVLDNCI 457
C+ C + WM+R CP CR ++ + +L+N +
Sbjct: 233 CAACYSGWMERSSLCPTCRCPVERICKNHILNNLV 267
>gi|239048905 checkpoint with forkhead and ring finger domains
isoform 3 [Homo sapiens]
Length = 652
Score = 53.9 bits (128), Expect = 3e-07
Identities = 29/95 (30%), Positives = 48/95 (50%), Gaps = 8/95 (8%)
Query: 364 IIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEAVTLN-CAHSF 422
++ A+ + QT E + A K D +E L CIIC + + V+L C H+F
Sbjct: 260 LLVAQPRRNAQTVHEDVRAAAGKP-------DKMEETLTCIICQDLLHDCVSLQPCMHTF 312
Query: 423 CSYCINEWMKRKIECPICRKDIKSKTYSLVLDNCI 457
C+ C + WM+R CP CR ++ + +L+N +
Sbjct: 313 CAACYSGWMERSSLCPTCRCPVERICKNHILNNLV 347
>gi|239048907 checkpoint with forkhead and ring finger domains
isoform 4 [Homo sapiens]
Length = 623
Score = 53.9 bits (128), Expect = 3e-07
Identities = 29/95 (30%), Positives = 48/95 (50%), Gaps = 8/95 (8%)
Query: 364 IIQAKNKELEQTKEEKEKMQAQKEEVLSHMNDVLENELQCIICSEYFIEAVTLN-CAHSF 422
++ A+ + QT E + A K D +E L CIIC + + V+L C H+F
Sbjct: 231 LLVAQPRRNAQTVHEDVRAAAGKP-------DKMEETLTCIICQDLLHDCVSLQPCMHTF 283
Query: 423 CSYCINEWMKRKIECPICRKDIKSKTYSLVLDNCI 457
C+ C + WM+R CP CR ++ + +L+N +
Sbjct: 284 CAACYSGWMERSSLCPTCRCPVERICKNHILNNLV 318
>gi|25777698 tripartite motif-containing 39 isoform 2 [Homo sapiens]
Length = 488
Score = 53.5 bits (127), Expect = 4e-07
Identities = 21/49 (42%), Positives = 28/49 (57%), Gaps = 3/49 (6%)
Query: 397 LENELQCIICSEYFIEAVTLNCAHSFCSYCINEW---MKRKIECPICRK 442
L+ E C +C EY E V + C H+FC CI W ++R CP+CRK
Sbjct: 23 LQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRK 71
>gi|25777696 tripartite motif-containing 39 isoform 1 [Homo sapiens]
Length = 518
Score = 53.5 bits (127), Expect = 4e-07
Identities = 21/49 (42%), Positives = 28/49 (57%), Gaps = 3/49 (6%)
Query: 397 LENELQCIICSEYFIEAVTLNCAHSFCSYCINEW---MKRKIECPICRK 442
L+ E C +C EY E V + C H+FC CI W ++R CP+CRK
Sbjct: 23 LQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRK 71
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.130 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,563,350
Number of Sequences: 37866
Number of extensions: 907449
Number of successful extensions: 10679
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 448
Number of HSP's successfully gapped in prelim test: 1031
Number of HSP's that attempted gapping in prelim test: 5143
Number of HSP's gapped (non-prelim): 4394
length of query: 485
length of database: 18,247,518
effective HSP length: 106
effective length of query: 379
effective length of database: 14,233,722
effective search space: 5394580638
effective search space used: 5394580638
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.