Search of human proteins with 4504825

Search of human proteins with 4504825

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4504825 potassium voltage-gated channel, shaker-related
subfamily, beta member 2 isoform 1 [Homo sapiens]
         (367 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4504825 potassium voltage-gated channel, shaker-related subfa...   738   0.0  
gi|27436969 potassium voltage-gated channel, shaker-related subf...   700   0.0  
gi|27436964 potassium voltage-gated channel, shaker-related subf...   587   e-168
gi|27436962 potassium voltage-gated channel, shaker-related subf...   585   e-167
gi|27436966 potassium voltage-gated channel, shaker-related subf...   583   e-167
gi|27436971 potassium voltage-gated channel, shaker-related subf...   516   e-147
gi|41327764 aldo-keto reductase family 7, member A2 [Homo sapiens]     87   2e-17
gi|223718702 aflatoxin B1 aldehyde reductase 3 isoform 1 [Homo s...    86   5e-17
gi|41152114 aldo-keto reductase family 7, member A3 [Homo sapiens]     83   3e-16
gi|223718708 aflatoxin B1 aldehyde reductase 3 isoform 2 [Homo s...    59   5e-09
gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens]     45   8e-05
gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens]      45   8e-05
gi|4502049 aldo-keto reductase family 1, member B1 [Homo sapiens]      43   5e-04
gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens]     38   0.013
gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens]      38   0.013
gi|93277124 aldo-keto reductase family 1, member C-like 2 [Homo ...    35   0.11 
gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens]      34   0.18 
gi|207028673 hypothetical protein LOC100134257 [Homo sapiens]          34   0.18 
gi|24497583 aldo-keto reductase family 1, member C3 [Homo sapiens]     34   0.24 
gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens]     32   0.90 
gi|5174695 aldo-keto reductase family 1, member D1 [Homo sapiens]      30   3.4  
gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo sap...    29   7.6  
gi|55749758 DIP2 disco-interacting protein 2 homolog B [Homo sap...    29   7.6  

>gi|4504825 potassium voltage-gated channel, shaker-related
           subfamily, beta member 2 isoform 1 [Homo sapiens]
          Length = 367

 Score =  738 bits (1906), Expect = 0.0
 Identities = 367/367 (100%), Positives = 367/367 (100%)

Query: 1   MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTF 60
           MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTF
Sbjct: 1   MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTF 60

Query: 61  GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 120
           GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF
Sbjct: 61  GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 120

Query: 121 WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG 180
           WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG
Sbjct: 121 WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG 180

Query: 181 MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA 240
           MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA
Sbjct: 181 MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA 240

Query: 241 MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG 300
           MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG
Sbjct: 241 MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG 300

Query: 301 CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY 360
           CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY
Sbjct: 301 CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY 360

Query: 361 SKKDYRS 367
           SKKDYRS
Sbjct: 361 SKKDYRS 367


>gi|27436969 potassium voltage-gated channel, shaker-related
           subfamily, beta member 2 isoform 2 [Homo sapiens]
          Length = 353

 Score =  700 bits (1806), Expect = 0.0
 Identities = 353/367 (96%), Positives = 353/367 (96%), Gaps = 14/367 (3%)

Query: 1   MYPESTTGSPARLSLRQTGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTF 60
           MYPESTTGSPARLSLRQTGSPGMIY              RNLGKSGLRVSCLGLGTWVTF
Sbjct: 1   MYPESTTGSPARLSLRQTGSPGMIY--------------RNLGKSGLRVSCLGLGTWVTF 46

Query: 61  GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 120
           GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF
Sbjct: 47  GGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 106

Query: 121 WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG 180
           WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG
Sbjct: 107 WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG 166

Query: 181 MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA 240
           MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA
Sbjct: 167 MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA 226

Query: 241 MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG 300
           MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG
Sbjct: 227 MTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLG 286

Query: 301 CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY 360
           CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY
Sbjct: 287 CTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPY 346

Query: 361 SKKDYRS 367
           SKKDYRS
Sbjct: 347 SKKDYRS 353


>gi|27436964 potassium voltage-gated channel, shaker-related
           subfamily, beta member 1 isoform 3 [Homo sapiens]
          Length = 401

 Score =  587 bits (1512), Expect = e-168
 Identities = 282/350 (80%), Positives = 322/350 (92%)

Query: 18  TGSPGMIYSTRYGSPKRQLQFYRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAY 77
           T +P    S +  + K+    YRNLGKSGLRVSCLGLGTWVTFGGQI+DE+AE+LMT+AY
Sbjct: 52  TFTPQHHISLKESTAKQTGMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAY 111

Query: 78  DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHII 137
           ++G+NLFDTAEVYAAGKAEV+LG+IIKKKGWRRSSLVITTK++WGGKAETERGLSRKHII
Sbjct: 112 ESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHII 171

Query: 138 EGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIME 197
           EGLK SL+RLQLEYVDVVFANRPD NTPMEE VRAMTHVINQGMAMYWGTSRWS+MEIME
Sbjct: 172 EGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIME 231

Query: 198 AYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDS 257
           AYSVARQFN+ PP+CEQAEYH+FQREKVEVQLPEL+HKIGVGAMTWSPLACGI+SGKY +
Sbjct: 232 AYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGN 291

Query: 258 GIPPYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGV 317
           G+P  SRASLK YQWLK++I+SEEGR+QQ KLK+L  IAERLGCTLPQLA+AWCLRNEGV
Sbjct: 292 GVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGV 351

Query: 318 SSVLLGASNADQLMENIGAIQVLPKLSSSIIHEIDSILGNKPYSKKDYRS 367
           SSVLLG+S  +QL+EN+GAIQVLPK++S +++EID+IL NKPYSKKDYRS
Sbjct: 352 SSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS 401


>gi|27436962 potassium voltage-gated channel, shaker-related
           subfamily, beta member 1 isoform 2 [Homo sapiens]
          Length = 408

 Score =  585 bits (1509), Expect = e-167
 Identities = 278/329 (84%), Positives = 314/329 (95%)

Query: 39  YRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVV 98
           YRNLGKSGLRVSCLGLGTWVTFGGQI+DE+AE+LMT+AY++G+NLFDTAEVYAAGKAEV+
Sbjct: 80  YRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVI 139

Query: 99  LGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFAN 158
           LG+IIKKKGWRRSSLVITTK++WGGKAETERGLSRKHIIEGLK SL+RLQLEYVDVVFAN
Sbjct: 140 LGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFAN 199

Query: 159 RPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYH 218
           RPD NTPMEE VRAMTHVINQGMAMYWGTSRWS+MEIMEAYSVARQFN+ PP+CEQAEYH
Sbjct: 200 RPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYH 259

Query: 219 MFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKIL 278
           +FQREKVEVQLPEL+HKIGVGAMTWSPLACGI+SGKY +G+P  SRASLK YQWLK++I+
Sbjct: 260 LFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIV 319

Query: 279 SEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQ 338
           SEEGR+QQ KLK+L  IAERLGCTLPQLA+AWCLRNEGVSSVLLG+S  +QL+EN+GAIQ
Sbjct: 320 SEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQ 379

Query: 339 VLPKLSSSIIHEIDSILGNKPYSKKDYRS 367
           VLPK++S +++EID+IL NKPYSKKDYRS
Sbjct: 380 VLPKMTSHVVNEIDNILRNKPYSKKDYRS 408


>gi|27436966 potassium voltage-gated channel, shaker-related
           subfamily, beta member 1 isoform 1 [Homo sapiens]
          Length = 419

 Score =  583 bits (1504), Expect = e-167
 Identities = 277/329 (84%), Positives = 314/329 (95%)

Query: 39  YRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVV 98
           +RNLGKSGLRVSCLGLGTWVTFGGQI+DE+AE+LMT+AY++G+NLFDTAEVYAAGKAEV+
Sbjct: 91  HRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVI 150

Query: 99  LGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFAN 158
           LG+IIKKKGWRRSSLVITTK++WGGKAETERGLSRKHIIEGLK SL+RLQLEYVDVVFAN
Sbjct: 151 LGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFAN 210

Query: 159 RPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYH 218
           RPD NTPMEE VRAMTHVINQGMAMYWGTSRWS+MEIMEAYSVARQFN+ PP+CEQAEYH
Sbjct: 211 RPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYH 270

Query: 219 MFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKIL 278
           +FQREKVEVQLPEL+HKIGVGAMTWSPLACGI+SGKY +G+P  SRASLK YQWLK++I+
Sbjct: 271 LFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIV 330

Query: 279 SEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQ 338
           SEEGR+QQ KLK+L  IAERLGCTLPQLA+AWCLRNEGVSSVLLG+S  +QL+EN+GAIQ
Sbjct: 331 SEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQ 390

Query: 339 VLPKLSSSIIHEIDSILGNKPYSKKDYRS 367
           VLPK++S +++EID+IL NKPYSKKDYRS
Sbjct: 391 VLPKMTSHVVNEIDNILRNKPYSKKDYRS 419


>gi|27436971 potassium voltage-gated channel, shaker-related
           subfamily, beta member 3 [Homo sapiens]
          Length = 404

 Score =  516 bits (1330), Expect = e-147
 Identities = 241/325 (74%), Positives = 290/325 (89%)

Query: 39  YRNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVV 98
           YRNLGKSGLRVSCLGLGTWVTFG QI+DE AE ++T+AY++G+NLFDTAEVYAAGKAE  
Sbjct: 80  YRNLGKSGLRVSCLGLGTWVTFGSQISDETAEDVLTVAYEHGVNLFDTAEVYAAGKAERT 139

Query: 99  LGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFAN 158
           LGNI+K KGWRRSS VITTKIFWGG+AETERGLSRKHIIEGL+ SLERLQL YVD+VFAN
Sbjct: 140 LGNILKSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLRGSLERLQLGYVDIVFAN 199

Query: 159 RPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYH 218
           R DPN PMEE VRAMT+VINQG+A+YWGTSRW + EIMEAYS+ARQFNL PP+CEQAE+H
Sbjct: 200 RSDPNCPMEEIVRAMTYVINQGLALYWGTSRWGAAEIMEAYSMARQFNLIPPVCEQAEHH 259

Query: 219 MFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIPPYSRASLKGYQWLKDKIL 278
           +FQREKVE+QLPEL+HKIGVG++TW PLACG+++ KYD  +P   RAS+KGYQWLKDK+ 
Sbjct: 260 LFQREKVEMQLPELYHKIGVGSVTWYPLACGLITSKYDGRVPDTCRASIKGYQWLKDKVQ 319

Query: 279 SEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNADQLMENIGAIQ 338
           SE+G++QQAK+ +L  +A +LGCT+ QLAIAWCLR+EGVSSVLLG S+A+QL+E++GA+Q
Sbjct: 320 SEDGKKQQAKVMDLLPVAHQLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLIEHLGALQ 379

Query: 339 VLPKLSSSIIHEIDSILGNKPYSKK 363
           VL +L+   + EID +LGNKP+SKK
Sbjct: 380 VLSQLTPQTVMEIDGLLGNKPHSKK 404


>gi|41327764 aldo-keto reductase family 7, member A2 [Homo sapiens]
          Length = 359

 Score = 87.0 bits (214), Expect = 2e-17
 Identities = 77/278 (27%), Positives = 127/278 (45%), Gaps = 22/278 (7%)

Query: 78  DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF-WGGKAETERGLSRKHI 136
           + G    DTA +Y+ G++E +LG +    G     + I TK   W GK+     L    +
Sbjct: 65  ERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKS-----LKPDSV 119

Query: 137 IEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIM 196
              L+ SL+RLQ   VD+ + + PD  TP+EET+ A   +  +G  +  G S ++S E+ 
Sbjct: 120 RSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVA 179

Query: 197 EAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKY- 255
           E  ++ +      P   Q  Y+   R+ VE +L       G+    ++PLA G+++GKY 
Sbjct: 180 EICTLCKSNGWILPTVYQGMYNATTRQ-VETELFPCLRHFGLRFYAYNPLAGGLLTGKYK 238

Query: 256 ---DSGIPPYSRASLKGYQW---LKDKILSEEGRRQQAKL-KELQAIAERLGCTLPQLAI 308
                G  P  R    G  W    +++   E      A + K LQA       ++   A+
Sbjct: 239 YEDKDGKQPVGR--FFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAAL 296

Query: 309 AWC-----LRNEGVSSVLLGASNADQLMENIGAIQVLP 341
            W      L+     +V+LG S+ +QL +N+ A +  P
Sbjct: 297 RWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGP 334


>gi|223718702 aflatoxin B1 aldehyde reductase 3 isoform 1 [Homo
           sapiens]
          Length = 331

 Score = 85.9 bits (211), Expect = 5e-17
 Identities = 80/295 (27%), Positives = 134/295 (45%), Gaps = 23/295 (7%)

Query: 62  GQITDEMAEQLMTLAY-DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 120
           G+  D      +T A+ + G    DTA +Y+ G++E +LG +  + G     + I TK  
Sbjct: 20  GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKAN 79

Query: 121 -WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQ 179
            W G +     L    +   L+ SL+RLQ   VD+ + + PD + P+EET+RA   +  +
Sbjct: 80  PWIGNS-----LKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQE 134

Query: 180 GMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVG 239
           G  +  G S +++ E+ E  ++ +      P   Q  Y    R+ VE +L       G+ 
Sbjct: 135 GKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQ-VETELFPCLRHFGLR 193

Query: 240 AMTWSPLACGIVSGKY----DSGIPPYSRASLKGYQW---LKDKILSEEGRRQQAKL-KE 291
              ++PLA G+++GKY      G  P  R    G QW    ++    E      A + K 
Sbjct: 194 FYAYNPLAGGLLTGKYKYEDKDGKQPVGR--FFGTQWAEIYRNHFWKEHHFEGIALVEKA 251

Query: 292 LQAIAERLGCTLPQLAIAWC-----LRNEGVSSVLLGASNADQLMENIGAIQVLP 341
           LQA       ++   A+ W      L+     +V+LG S+ +QL +N+ A +  P
Sbjct: 252 LQAAYGASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGP 306


>gi|41152114 aldo-keto reductase family 7, member A3 [Homo sapiens]
          Length = 331

 Score = 83.2 bits (204), Expect = 3e-16
 Identities = 78/294 (26%), Positives = 133/294 (45%), Gaps = 21/294 (7%)

Query: 62  GQITDEMAEQLMTLAY-DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 120
           G+  D      +T A+ + G    DTA VY+ G++E +LG +  + G     + I TK  
Sbjct: 20  GRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAI 79

Query: 121 WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQG 180
                     L    +   L+ SL+RLQ   VD+ + + PD +TP+EET+RA   +  +G
Sbjct: 80  ----PLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEG 135

Query: 181 MAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAEYHMFQREKVEVQLPELFHKIGVGA 240
             +  G S +++ E+ E  ++ +      P   Q  Y+   R+ VE +L       G+  
Sbjct: 136 KFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQ-VETELFPCLRHFGLRF 194

Query: 241 MTWSPLACGIVSGKY----DSGIPPYSRASLKGYQW---LKDKILSEEGRRQQAKL-KEL 292
             ++PLA G+++GKY     +G  P  R    G  W    +++   E      A + K L
Sbjct: 195 YAFNPLAGGLLTGKYKYEDKNGKQPVGR--FFGNTWAEMYRNRYWKEHHFEGIALVEKAL 252

Query: 293 QAIAERLGCTLPQLAIAWC-----LRNEGVSSVLLGASNADQLMENIGAIQVLP 341
           QA       ++    + W      L+     +V+LG S+ +QL +N+ A +  P
Sbjct: 253 QAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGP 306


>gi|223718708 aflatoxin B1 aldehyde reductase 3 isoform 2 [Homo
           sapiens]
          Length = 249

 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 41/144 (28%), Positives = 73/144 (50%), Gaps = 7/144 (4%)

Query: 62  GQITDEMAEQLMTLAY-DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF 120
           G+  D      +T A+ + G    DTA +Y+ G++E +LG +  + G     + I TK  
Sbjct: 20  GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKAN 79

Query: 121 -WGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQ 179
            W G +     L    +   L+ SL+RLQ   VD+ + + PD + P+EET+RA   +  +
Sbjct: 80  PWIGNS-----LKPDSVRSQLETSLKRLQCPUVDLFYLHAPDHSAPVEETLRACHQLHQE 134

Query: 180 GMAMYWGTSRWSSMEIMEAYSVAR 203
           G  +  G S +++ E+ E  ++ +
Sbjct: 135 GKFVELGLSNYAAWEVAEICTLCK 158


>gi|24497577 aldo-keto reductase family 1, member A1 [Homo sapiens]
          Length = 325

 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 50/200 (25%), Positives = 85/200 (42%), Gaps = 43/200 (21%)

Query: 45  SGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 104
           +G ++  +GLGTW +  GQ+     +  +  A   G    D A +Y     E  +G  +K
Sbjct: 10  TGQKMPLIGLGTWKSEPGQV-----KAAVKYALSVGYRHIDCAAIYGN---EPEIGEALK 61

Query: 105 K-----KGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 159
           +     K   R  L +T+K+ W  K   E       +   L+ +L  LQLEY+D+   + 
Sbjct: 62  EDVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 114

Query: 160 P-------DP------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 200
           P       +P            +T  +ET +A+  ++ +G+    G S ++S +I +  S
Sbjct: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174

Query: 201 VARQFNLTPPICEQAEYHMF 220
           VA       P   Q E H +
Sbjct: 175 VAS----VRPAVLQVECHPY 190


>gi|5174391 aldo-keto reductase family 1, member A1 [Homo sapiens]
          Length = 325

 Score = 45.4 bits (106), Expect = 8e-05
 Identities = 50/200 (25%), Positives = 85/200 (42%), Gaps = 43/200 (21%)

Query: 45  SGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIK 104
           +G ++  +GLGTW +  GQ+     +  +  A   G    D A +Y     E  +G  +K
Sbjct: 10  TGQKMPLIGLGTWKSEPGQV-----KAAVKYALSVGYRHIDCAAIYGN---EPEIGEALK 61

Query: 105 K-----KGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANR 159
           +     K   R  L +T+K+ W  K   E       +   L+ +L  LQLEY+D+   + 
Sbjct: 62  EDVGPGKAVPREELFVTSKL-WNTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 114

Query: 160 P-------DP------------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 200
           P       +P            +T  +ET +A+  ++ +G+    G S ++S +I +  S
Sbjct: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174

Query: 201 VARQFNLTPPICEQAEYHMF 220
           VA       P   Q E H +
Sbjct: 175 VAS----VRPAVLQVECHPY 190


>gi|4502049 aldo-keto reductase family 1, member B1 [Homo sapiens]
          Length = 316

 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 41/176 (23%), Positives = 79/176 (44%), Gaps = 32/176 (18%)

Query: 40  RNLGKSGLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYA-AGKAEVV 98
           R L  +G ++  LGLGTW +  GQ+T     + + +A D G    D A VY    +  V 
Sbjct: 4   RLLLNNGAKMPILGLGTWKSPPGQVT-----EAVKVAIDVGYRHIDCAHVYQNENEVGVA 58

Query: 99  LGNIIKKKGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFAN 158
           +   ++++  +R  L I +K++       E+GL    +    + +L  L+L+Y+D+   +
Sbjct: 59  IQEKLREQVVKREELFIVSKLWC---TYHEKGL----VKGACQKTLSDLKLDYLDLYLIH 111

Query: 159 RPDPNTPMEE-------------------TVRAMTHVINQGMAMYWGTSRWSSMEI 195
            P    P +E                   T  AM  ++++G+    G S ++ +++
Sbjct: 112 WPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQV 167


>gi|45446745 aldo-keto reductase family 1, member C2 [Homo sapiens]
          Length = 323

 Score = 38.1 bits (87), Expect = 0.013
 Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 43/199 (21%)

Query: 52  LGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKK----G 107
           LG GT+     ++    A + + LA + G +  D+A VY     E  +G  I+ K     
Sbjct: 19  LGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKIADGS 73

Query: 108 WRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPME 167
            +R  +  T+K+ W      E       +   L+ SL+ LQL+YVD+   + P    P E
Sbjct: 74  VKREDIFYTSKL-WSNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFPVSVKPGE 126

Query: 168 ETVRAMTHVINQGMAMYWGT----SRWSSMEIMEAYSVARQFNLT--------------- 208
           E +       ++   + + T    + W +ME  +   +A+   ++               
Sbjct: 127 EVIPK-----DENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPG 181

Query: 209 ---PPICEQAEYHMFQREK 224
               P+C Q E H +  ++
Sbjct: 182 LKYKPVCNQVECHPYFNQR 200


>gi|4503285 aldo-keto reductase family 1, member C2 [Homo sapiens]
          Length = 323

 Score = 38.1 bits (87), Expect = 0.013
 Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 43/199 (21%)

Query: 52  LGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKK----G 107
           LG GT+     ++    A + + LA + G +  D+A VY     E  +G  I+ K     
Sbjct: 19  LGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKIADGS 73

Query: 108 WRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPME 167
            +R  +  T+K+ W      E       +   L+ SL+ LQL+YVD+   + P    P E
Sbjct: 74  VKREDIFYTSKL-WSNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFPVSVKPGE 126

Query: 168 ETVRAMTHVINQGMAMYWGT----SRWSSMEIMEAYSVARQFNLT--------------- 208
           E +       ++   + + T    + W +ME  +   +A+   ++               
Sbjct: 127 EVIPK-----DENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPG 181

Query: 209 ---PPICEQAEYHMFQREK 224
               P+C Q E H +  ++
Sbjct: 182 LKYKPVCNQVECHPYFNQR 200


>gi|93277124 aldo-keto reductase family 1, member C-like 2 [Homo
           sapiens]
          Length = 320

 Score = 35.0 bits (79), Expect = 0.11
 Identities = 33/115 (28%), Positives = 53/115 (46%), Gaps = 17/115 (14%)

Query: 49  VSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLG--NIIKKK 106
           +  +GL +W    G++T+ + E     A D G   FD A  Y   + EV  G    IK+ 
Sbjct: 4   IPAVGLSSWKASPGKVTEAVKE-----AIDAGYRHFDCAYFY-HNEREVGAGIRCKIKEG 57

Query: 107 GWRRSSLVITTKIFWGGKAETERGLSRKHIIE-GLKASLERLQLEYVDVVFANRP 160
             RR  L I TK++            +K ++E   + SL+ L+L Y+D+   + P
Sbjct: 58  AVRREDLFIATKLWC--------TCHKKSLVETACRKSLKALKLNYLDLYLIHWP 104


>gi|5453543 aldo-keto reductase family 1, member C1 [Homo sapiens]
          Length = 323

 Score = 34.3 bits (77), Expect = 0.18
 Identities = 33/123 (26%), Positives = 53/123 (43%), Gaps = 16/123 (13%)

Query: 52  LGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKK----G 107
           LG GT+     ++    A +   LA + G    D+A +Y     E  +G  I+ K     
Sbjct: 19  LGFGTYAP--AEVPKSKALEATKLAIEAGFRHIDSAHLY---NNEEQVGLAIRSKIADGS 73

Query: 108 WRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPME 167
            +R  +  T+K+ W      E       +   L+ SL+ LQL+YVD+   + P    P E
Sbjct: 74  VKREDIFYTSKL-WCNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFPVSVKPGE 126

Query: 168 ETV 170
           E +
Sbjct: 127 EVI 129


>gi|207028673 hypothetical protein LOC100134257 [Homo sapiens]
          Length = 139

 Score = 34.3 bits (77), Expect = 0.18
 Identities = 31/113 (27%), Positives = 51/113 (45%), Gaps = 16/113 (14%)

Query: 52  LGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKK----G 107
           LG GT+     ++    A + + LA + G +  D+A VY     E  +G  I+ K     
Sbjct: 19  LGFGTYAP--AEVPKSKALEAVKLAIEAGFHHIDSAHVY---NNEEQVGLAIRSKIADGS 73

Query: 108 WRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP 160
            +R  +  T+K+ W      E       +   L+ SL+ LQL+YVD+   + P
Sbjct: 74  VKREDIFYTSKL-WSNSHRPEL------VRPALERSLKNLQLDYVDLYLIHFP 119


>gi|24497583 aldo-keto reductase family 1, member C3 [Homo sapiens]
          Length = 323

 Score = 33.9 bits (76), Expect = 0.24
 Identities = 48/199 (24%), Positives = 79/199 (39%), Gaps = 40/199 (20%)

Query: 52  LGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKK----G 107
           LG GT+     ++    A ++  LA + G    D+A +Y     E  +G  I+ K     
Sbjct: 19  LGFGTYAP--PEVPRSKALEVTKLAIEAGFRHIDSAHLY---NNEEQVGLAIRSKIADGS 73

Query: 108 WRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPME 167
            +R  +  T+K+ W      E       +   L+ SL++ QL+YVD+   + P    P E
Sbjct: 74  VKREDIFYTSKL-WSTFHRPEL------VRPALENSLKKAQLDYVDLYLIHSPMSLKPGE 126

Query: 168 E-------------------TVRAMTHVINQGMAMYWGTSRWSSMEI-MEAYSVARQFNL 207
           E                   T  AM    + G+A   G S ++  ++ M       ++  
Sbjct: 127 ELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYK- 185

Query: 208 TPPICEQAEYH-MFQREKV 225
             P+C Q E H  F R K+
Sbjct: 186 --PVCNQVECHPYFNRSKL 202


>gi|24497585 aldo-keto reductase family 1, member C4 [Homo sapiens]
          Length = 323

 Score = 32.0 bits (71), Expect = 0.90
 Identities = 37/175 (21%), Positives = 74/175 (42%), Gaps = 29/175 (16%)

Query: 52  LGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKK----G 107
           LG GT+     ++    A ++  LA + G    D+A +Y     E  +G  I+ K     
Sbjct: 19  LGFGTYAP--PEVPRNRAVEVTKLAIEAGFRHIDSAYLY---NNEEQVGLAIRSKIADGS 73

Query: 108 WRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVFANRP------D 161
            +R  +  T+K++             + +   L++SL++LQL+YVD+   + P      +
Sbjct: 74  VKREDIFYTSKLWC-------TFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 126

Query: 162 PNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQAE 216
              P +E  + +   ++        ++ W  ME  +   +A+   ++   C Q E
Sbjct: 127 TPLPKDENGKVIFDTVDL-------SATWEVMEKCKDAGLAKSIGVSNFNCRQLE 174


>gi|5174695 aldo-keto reductase family 1, member D1 [Homo sapiens]
          Length = 326

 Score = 30.0 bits (66), Expect = 3.4
 Identities = 49/202 (24%), Positives = 80/202 (39%), Gaps = 40/202 (19%)

Query: 46  GLRVSCLGLGTWVTFGGQITDEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKK 105
           G  +  +GLGT+           A  +  +A D G    D A +Y   + E  +G  I++
Sbjct: 15  GNSIPIIGLGTYSEPKSTPKGACATSVK-VAIDTGYRHIDGAYIY---QNEHEVGEAIRE 70

Query: 106 KGWRRSSLVITTKIFWGGKAETERGLSRKHIIEGLKASLER----LQLEYVDVVFANRP- 160
           K       V    IF+ GK       +  H+ E ++ +LER    LQL+YVD+     P 
Sbjct: 71  K--IAEGKVRREDIFYCGKL-----WATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPM 123

Query: 161 -----DPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLTPPICEQA 215
                D   P +E  + + H  N         + W +ME  +   + +   ++       
Sbjct: 124 AFKPGDEIYPRDENGKWLYHKSNL-------CATWEAMEACKDAGLVKSLGVS------- 169

Query: 216 EYHMFQREKVEVQL--PELFHK 235
               F R ++E+ L  P L HK
Sbjct: 170 ---NFNRRQLELILNKPGLKHK 188


>gi|58530886 interleukin-1 receptor-associated kinase 2 [Homo
           sapiens]
          Length = 625

 Score = 28.9 bits (63), Expect = 7.6
 Identities = 25/88 (28%), Positives = 39/88 (44%), Gaps = 15/88 (17%)

Query: 206 NLTP----------PICEQAEYHMFQREKVEVQ---LPELFHKIGVGAMTWSPLACGIVS 252
           NLTP          P+ ++++Y M +   +      LPE F ++G         +CGIV 
Sbjct: 346 NLTPKLAHPMAHLCPVNKRSKYTMMKTHLLRTSAAYLPEDFIRVGQLTKRVDIFSCGIVL 405

Query: 253 GKYDSGIPPYSRASLKGYQWLKDKILSE 280
            +  +GIP         Y  LKD +LS+
Sbjct: 406 AEVLTGIPAMDNNRSPVY--LKDLLLSD 431


>gi|55749758 DIP2 disco-interacting protein 2 homolog B [Homo
           sapiens]
          Length = 1576

 Score = 28.9 bits (63), Expect = 7.6
 Identities = 18/51 (35%), Positives = 25/51 (49%)

Query: 66  DEMAEQLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVIT 116
           D   +Q+  L    GI L  T+EV   G  +   G I++ KGW R   V+T
Sbjct: 440 DAGGQQIGFLLGSCGIALALTSEVCLKGLPKTQNGEIVQFKGWPRLKWVVT 490


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.397 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,493,756
Number of Sequences: 37866
Number of extensions: 555276
Number of successful extensions: 1331
Number of sequences better than 10.0: 23
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 1305
Number of HSP's gapped (non-prelim): 23
length of query: 367
length of database: 18,247,518
effective HSP length: 104
effective length of query: 263
effective length of database: 14,309,454
effective search space: 3763386402
effective search space used: 3763386402
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.